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<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W2G0</accession>
    <name>A0A6G0W2G0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Pyridoxal phosphate phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_011280</name>
        <name evidence="8" type="ORF">Ae201684_019247</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000563">
        <property type="protein sequence ID" value="KAF0720988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VJMJ01000143">
        <property type="protein sequence ID" value="KAF0731377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W2G0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018551"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006384">
        <property type="entry name" value="HAD_hydro_PyrdxlP_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016965">
        <property type="entry name" value="Pase_PHOSPHO-typ"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01489">
        <property type="entry name" value="DKMTPPase-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01488">
        <property type="entry name" value="HAD-SF-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20889:SF12">
        <property type="entry name" value="LP01149P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20889">
        <property type="entry name" value="PHOSPHATASE, ORPHAN 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06888">
        <property type="entry name" value="Put_Phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031051">
        <property type="entry name" value="PyrdxlP_Pase_PHOSPHO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="10"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR031051-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR031051-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR031051-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0720988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0731377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="25842" checksum="861A1AF243A19F3D" modified="2020-08-12" version="1">MTGLVIFDYDWSLINDNSDTYVFQQLQPELYTHLRQLSSSGVQWTQAVDQTLAKLTCTKEQLIDALARIPIQDGMLEAVQFAHTKGCEIVIVSDANTVFIQSMLEHHNLTSIIKQVYTNPAVFEGNVLHVSPFHASNLPPHGCPRCPPNMCKGSIVQQIQASKTYSKIIYIGDGGGDFCPCATQLSSNDVVFAREQYELLRRLQANSGDVSATVEPWSTGLDILAGFQRHIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W2W5</accession>
    <name>A0A6G0W2W5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_019211</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000498">
        <property type="protein sequence ID" value="KAF0721179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W2W5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002948"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="338"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0721179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="400" mass="44164" checksum="8E0B5486FCDBBD3A" modified="2020-08-12" version="1">MGANSEFEAFFRAVQNNDVHLVKTLLDAGFDVNAQSTVQSTNRNGQYIIWKSSALMYAARYGQEDMVGLILAQDLVDVNTAQEKHGWTALLMAAANDHTNIVKLLLKRGDIDVNLKDCNGLSPLHDATKEDVNAKDNRDGSPLHTAVTHGRLDIVNLILGHGAINVSAKQKYIGSAFDIAASKGHIEILQLLLRYGRSDFRFLSENLGEMLKRASMNGHLNIVQLLLRDFATTIDLQPTALAIALHDATKNGHIDIVRLLLRQNRIDINFSNQFMGTALQSVAINGLLEIGQLILARDDVSSENVSIASHNAAGRGHIDILRLLLAYHGVNINFQNTEGKTALHFAAEKGFVEITRILLDHGINVNLVSEDFGTALHRELRESGNLQYIMRFMAISSYNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W3V7</accession>
    <name>A0A6G0W3V7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_011424</name>
        <name evidence="1" type="ORF">Ae201684_019174</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000445">
        <property type="protein sequence ID" value="KAF0721344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VJMJ01000144">
        <property type="protein sequence ID" value="KAF0731361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W3V7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008919"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0721344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0731361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="25578" checksum="88F95118BB1B305E" modified="2020-08-12" version="1">MDMLPADVIIKIVFYLPDLKDVLAFLDTLRPHTALETLGDLYQLSLTHNHASLGPTLTLNCSMVDTISIALCESIAKLYSHVLVVDSWFSVAWLKKHLNSMAMIEWEAMELPVTIDNVDDWADLRITQLSLSIKNDTPPTWKKALPRFTHLKSLFIEGPSEDLADVYEFVAKSAQITEFQIKPTDRRVDNAELIHLIEWLRRQPVRVFDGWYMNWREILIVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W668</accession>
    <name>A0A6G0W668_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_019062</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000382">
        <property type="protein sequence ID" value="KAF0721595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W668"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004090"/>
    <dbReference type="OrthoDB" id="9995831at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34213">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2 (NTF2) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34213:SF2">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2 (NTF2) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="2">
        <location>
            <begin position="36"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0721595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="186" mass="21036" checksum="ABFEB0F7FF903C05" modified="2020-08-12" version="1">MATRRKSAKPEMGMAQQITLKILSMYDRTTDSDAIIQELYHPNATFSDPWVEVKGRDKVAAHFRVIPSFVSTSHATLIRGSMAGVSILTIDSKVSFRFKPFPSFMGITFRMFSVIELQDQQVMTHTDHWDLSTVVENIPIVSLFYRLFRTAFGSASSHLINTFLPKPPPRRPQTAQLDDTATTTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W6K0</accession>
    <name>A0A6G0W6K0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Crinkler effector protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_018475</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Host cell</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000336">
        <property type="protein sequence ID" value="KAF0722406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W6K0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014257"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043657">
        <property type="term" value="C:host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052980">
        <property type="entry name" value="Crinkler_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045379">
        <property type="entry name" value="Crinkler_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33129:SF1">
        <property type="entry name" value="ATP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33129">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20147">
        <property type="entry name" value="Crinkler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Crinkler effector protein N-terminal" evidence="4">
        <location>
            <begin position="3"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0722406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="440" mass="50274" checksum="56C5B80C571087CE" modified="2020-08-12" version="1">MLRVNCIVVGKGNPFTVDVDGEKTVDDLKNAIIETSSHCRDATDLTLYRAFENKNDLKLDSPFIKRLKDGEIPDEVKSLLVEDMDSTTPLDEALKLPLDLNEIHVLVVVGEEKPRKKIKQNTTPRVEWFPSDLIKIDAGEIDEYEWLVMLYGQTFEILDFDEDDVEIMDMHYFEMEFPVLMVNPGTTQVFVRPCYEELFKLLMENINERVSSVGVKGTSGVGKSFFYVYCVFRLTLEPIDGRLLVINCADRFYVFEDNAFRFVSSDDEIEHYRCDKNVIRLIDGQSTKLLSWSGVSILFSSPDSPGYEQFMNANAVEYVMPPYLELRIGSLITDTNEKVDERYAVFGGRASVVFSKTPLANIDDVVGPVSMVDTMSLLTAFKTSDESKFPFVLHIFPKHEHKRPYRGVEMKYATNAVGKQAFNRMQDSYPGDLMDLLLNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W7X0</accession>
    <name>A0A6G0W7X0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_017839</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000313">
        <property type="protein sequence ID" value="KAF0723222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W7X0"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0723222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="205" mass="22755" checksum="8D1528CA46FAA2D9" modified="2020-08-12" version="1">MPSGKAFEKTTTASLRVDVVDMSLDKFERFRRTLVLLSSCLIPPRLPHIFETAESSISSTLPPLPPKQFDVLTLQSLKFNPRRPFGHRDAQSDDIQSFHRLDDFGMEQLDLMLVFQLDRSSSVILMDSFKATECPAPRCPASSEPPAPCQDDTASQRLNLELAQDISIVPCSPYRDLAAFPVSLQHQSGLSLSPSPPSPLMEQNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W9Q5</accession>
    <name>A0A6G0W9Q5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_017172</name>
        <name evidence="12" type="ORF">Ae201684_017178</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000285">
        <property type="protein sequence ID" value="KAF0724064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VJMJ01000285">
        <property type="protein sequence ID" value="KAF0724070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W9Q5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017423"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000054">
        <property type="entry name" value="Complement C1r subcomponent"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050127">
        <property type="entry name" value="Serine_Proteases_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264:SF65">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264">
        <property type="entry name" value="TRYPSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Peptidase S1" evidence="10">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="63"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="67"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0724064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0724070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="151" mass="15843" checksum="3627AD278AD557A0" modified="2020-08-12" version="1">MMCAGGEQGKDSCQGDSGGPLTVEQSGSEKLVGVVSWGIGCAEANKPGVYGRVSVARDFIAPYITNTPTPSTSKSTSSTSKPTPSSKTTFKPTTTPKTTTKKQKTLADVPAGCSSCSFCYYRGGKTCLEDFSEADCNNFSVDVNTVWCADY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WAR8</accession>
    <name>A0A6G0WAR8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_016999</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000273">
        <property type="protein sequence ID" value="KAF0724337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WAR8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021467"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="209"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="279"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="15"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="289"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0724337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="339" mass="38957" checksum="6809B89480A6BAFE" modified="2020-08-12" version="1">MCKPRHHATAITVRVNRLKLKIKQLRATRDELIAIANRLVELQEDLIAEKSKMEKVKDEALGRLEAELNEAKCRLSESQLRHQELMDQKDVLDSLPLESETTPYSGEAHLESTPDSNCDVTPHNSFDDKTIICGKLETITQGSEEACVHPPPRHGGRMPTALVMQKNRLNFSRKATKTEDIARLNDFVHEEAKPRAKTAKIGLLGKETHDRPQLTRRRPLGRNDVLIPTEREQMSRRPSPQAQLSRCKEVPGKKTQNDVATRRGIRACVSPREIKPRSRRVYEQLPEAVAKKQHDELERKRKSKLEDLQIQRQEQLRQKREQSQASRRDNKTRPTKATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WAX0</accession>
    <name>A0A6G0WAX0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein cereblon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_016815</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CRBN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000269">
        <property type="protein sequence ID" value="KAF0724521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WAX0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003601"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd15777">
        <property type="entry name" value="CRBN_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.150.20:FF:000007">
        <property type="entry name" value="Protein cereblon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.20">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034750">
        <property type="entry name" value="CULT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004910">
        <property type="entry name" value="Yippee/Mis18/Cereblon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46732">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE LA (LON) DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46732:SF8">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE LA (LON) DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03226">
        <property type="entry name" value="Yippee-Mis18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51788">
        <property type="entry name" value="CULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="10">
        <location>
            <begin position="55"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="CULT" evidence="11">
        <location>
            <begin position="276"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0724521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="385" mass="43186" checksum="E8CBB49C08F30B0A" modified="2020-08-12" version="1">MSNSADDEMSDASSLEEYGDSPIDPFLVDHSYLGEDMAVLGSKSAHFVPGSVVDMPLVVLPDLVIFPGETLPLRMLSTWTLQSMTSRLRHGNDVFAIINTERPRHVGTLIQIERVYEQGDMYLSIVGRGRQRFEIIERLHVSHVVSEANARIRVLPDLHAIPCPFPTLGTTRRKRPRLTTIAYWGPAEYAQFDGPSLVHQAKAILLQSVEWQAFLDASFSSSPSAPLASSPSDPTRFSYWLAGHLTLSLRDRQRLLAMSCVIGRLRSLIAWLQQHTSLIQCAGCATTLADTRDIFLQQDVDDGGPVSTFVNPHGSIHQILTMQRVAHSAFWPHGEPTLADTWFPGYTWQCIYCRVCANFLGWRYISTIEQVHPRVFYGLLRKAIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WBU2</accession>
    <name>A0A6G0WBU2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_016534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000257">
        <property type="protein sequence ID" value="KAF0724883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WBU2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009852"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="51"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0724883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="136" mass="15963" checksum="4988CDB480813207" modified="2020-08-12" version="1">MCGNEATTSINSPLTFVFILSVFIDDNFIRIHELYPHCENNMEWTLDALLADHLETEKQEKERKERLALKRERMKAKFAEEDTKLDEANAEAETNLNELSHVFELVESNAVRRLVERICQDKEDERDSDKTDNDME</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WCP9</accession>
    <name>A0A6G0WCP9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_016468</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000253">
        <property type="protein sequence ID" value="KAF0725071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WCP9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003473"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="117"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="227"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="430"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="575"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0725071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="874" mass="99548" checksum="1E5856AF5EDFC0C9" modified="2020-08-12" version="1">MHSHHDFTCGFLLKGVPPAKARTPFNGKLTRIFCVLITSRLDFYTKDPRPSFDAAIDGSYMFDKKTKIADCGDLYSGLPQYSFSISTNGESLLMVANTHEEMQLWLDAIRECIEHQVHIVRGTLLKKFNRRPKQPWAPREIELGHVSLTYLTSRLQDKVRNHVKLTSRSFVVDLAPMANHDYVFGICSGESSITFAAPTAEDKERWIREIEIRIARQRIHWRYFQKPSDLVGVVDVRLASNKTWRRRFCELERGVFAIKQDERRIGMEVHVPLELITSVRSGPDDIIGRTNAFAIERFGAVTLYVSAFSATEHRNWLTKLQQARRDWALQPNLYIFPNEMHALAATVGYRTVKLSPTEVLDAIIEQHRQRIFVVVPTSCQDAATYVPQASVLVSVKDPTGKHSTFDAMWHCLRVHRTYTDRPLKLTFRLPITKEGLLRVKTTVPVNQWVPRRCELAHGCFSWYALHGSNNERPIQVVRLRECSVTLLRDLDSDNSEMPHCFVLSTSTTHLRVLFSATSADDCVLWMSILQLEIATYTGDTRFAPALPTAAECRRNVIVKNVKVVAEKVYAKTVQNNTPENPADVQVEIKEPSEESKRSDSGDVDDGISMEDDDNDDEYLSFSEKFHRQCIEKPIKAYQSTKQELRRRASAYIETKRASIVAAPLYQRLRTAQSKLELQLAPAKEELERVTARVKQQAADTVSEIRSHLVIPDPETSDYFNGCKRYLGATILGKSVRRIEFTARRKAQRFIETDALVQAMHIGETTKEPPVVDVNRQAMLRPDAARDFFVELTQGRESTSLEALLTLMRQLCLSENGNIDNLSPFEAAIEALESRHELTYAISIEVFVNVATKTIRDVPTIHTMERLAKGILMLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WDN9</accession>
    <name>A0A6G0WDN9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endoribonuclease L-PSP/chorismate mutase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_016078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000242">
        <property type="protein sequence ID" value="KAF0725437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WDN9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002428"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02199">
        <property type="entry name" value="YjgF_YER057c_UK114_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013813">
        <property type="entry name" value="Endoribo_LPSP/chorism_mut-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43760:SF1">
        <property type="entry name" value="ENDORIBONUCLEASE L-PSP_CHORISMATE MUTASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43760">
        <property type="entry name" value="ENDORIBONUCLEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14588">
        <property type="entry name" value="YjgF_endoribonc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endoribonuclease L-PSP/chorismate mutase-like" evidence="1">
        <location>
            <begin position="20"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0725437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="170" mass="18013" checksum="6374DBB2521E160A" modified="2020-08-12" version="1">MFSRVLAKSSSALRRSVHTENRIKELGYTLPGVAAPKGNYRNSVRSGNMIFTAGHLPQPAGGDLVKGKIGDDLTIDQGYEAAQHCALALCATLKHELGDLDKVKRIVKVVGFVNCVDGFTAQPQVINGASDTLGKIFGERGVHSRSAVGTNALPLGVAVEVECIVEVEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WEE7</accession>
    <name>A0A6G0WEE7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase M14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_016647</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000265">
        <property type="protein sequence ID" value="KAF0724716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WEE7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013650"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF143">
        <property type="entry name" value="SLL0236 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026267804" description="Peptidase M14 domain-containing protein" evidence="8">
        <location>
            <begin position="18"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="9">
        <location>
            <begin position="71"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0724716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="234" mass="25915" checksum="C634EC4B03DB618E" modified="2020-08-12" version="1">MKLIYSALAIAAALVAAGDVDNDLIRGPDKVLRTSAQVQAIQDDAATNRKCHTSNSGYLTTLKAGTYTTSTYHNCFRTSTQIFEYVDKLVAQNPTLLTKFAITKTVKGQTIYGYKLVKNSSNSKYVYYESLIHAREWIAGSSLVYSFSSLLDDIANGNATIADQFNLYFVPIVNIDGYDISWNDNRYQRKNANEGFSQFAKETITFGSTKSAFLEDATVDSVNVTADFDHPILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WEF4</accession>
    <name>A0A6G0WEF4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_015878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000234">
        <property type="protein sequence ID" value="KAF0725726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WEF4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017193"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="375"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="409"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="433"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="469"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="499"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0725726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="583" mass="63437" checksum="16719248E8316D8B" modified="2020-08-12" version="1">MLAWLKRYFTLTIVAKSPNELMVERSLFLLSIGRDSYLRLGCWVFSRWWLLFASCITTFFAGSLLAFDSLAESLDLHFSTQDSNHLAAYALCCFAAVAFLSAPYFERQGPRFAMFIGSVLVATGFALSYLAVQSGHYTFLLLGHCGFTASGFGILVISAISTAQKWFPDLRGVVAGLATALGLSGYALFDAWYAFIASKPPSSHLTRVFLTSGLWISSGLFIASLVLRTPPPTFSIRGYDMHRVPLSRAPYPTYTQSKFLQNGLTCINFGAVAEELEASYCSHILPFSSRVDSDDEFYKIGMTLIDHAILESHSSRFQPLYKQQRKAMSLLGCFFSSDLIALAVSAACLLLPVQILVLQAHDISRNLFQSALPPALVLATGVAGAIASSFFSDALICILYSTSAQARKIVLEILLCLQLVALLLVAVNASNSVVFRVALSVVSFTGSGTLALLPAMITDLFGVFHTGPIYSFVLLPCVAQALLGGVVKTPLTPDALLHQVHWMLGLTTASAVALVIVRPRADDRFFHGYQYTAFGKTLLSRPIRTAARDTCLDDSVAMMDVGGLSYSYPPEEASAIWHAIKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WEM6</accession>
    <name>A0A6G0WEM6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_016557</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000261">
        <property type="protein sequence ID" value="KAF0724807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WEM6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020999"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0724807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="510" mass="57812" checksum="0C04D8D768E8A6C6" modified="2020-08-12" version="1">MLWEWLVMPQGLSNAPATFNRLVTDKLRHLRDFAPSYFDDIYVHSRASRDVSDVEVHRGHLRALFQVLRENGLYANLQKCMFGVNEIPVLGDFVGINGCRVDPAKVEAVTTWPTPQTVSELRSWLGLATYLHKFSKNFASIARPLSALLAKDVPWAWTDECQSAFDGIKTSLIEAPVLALPSRPFSVVCDASIQGIGCCLMQEDASGMNRPVSYQSRQLRAAERNYPVHDLELLAVKYALVKFRIYLLGSKPFVVYTDHAALKYAVKSPHISERMARWLAFFAEFNMAVEYKPGRESVLADALSRRPTTEDSSSVDLNRLTQVHSDLSDRIRRAYRMDPSLRSIVANFRSPKPDATLYERYSMRNGILYFQPATSTSPRMVVPCDVQLRTDLVSEHHDTPSGGHFDRDKTYVTLARQFWWPRMYKTVARYVASCSLCQKVKSSPSIHAPAQMLQVPKDIWSSVSMDYIFRLPRDGRSNTGIWACVDRASKFLVAIPVKDYHGGAIREAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WEW8</accession>
    <name>A0A6G0WEW8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DZANK-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_015903</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000237">
        <property type="protein sequence ID" value="KAF0725570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WEW8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021159"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025874">
        <property type="entry name" value="DZR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12773">
        <property type="entry name" value="DZR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DZANK-type" evidence="2">
        <location>
            <begin position="398"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="521"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0725570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="532" mass="56926" checksum="362EA8D8454A92A2" modified="2020-08-12" version="1">MGFCGECGAKDEGGKFCPECGAPVGADVGLFGSSSVALEAAPAPASSQRLEAEKRAAAAREMAEQARQEAAKAALVFEETEKRRLEDAYRAEEQQRLAQAESQREEILARQREAHAKREEAERQAEEARQRAIKLREDAAAATRLMEEQNRRREEEKLRILEQQRQMEIERLRAAHLAEADRARKAREDAEAKALEAKAAAEALRQKAIAAAAALEEQRRLQQQKIAEREEARRLREQQKEREAQEARANEARLQREAAERHAEEARRKAEQLRLQAAAADAKRLDKQASLSSSASSSTSCAQCAAPCKPTQKFCPKCGFKRVDSTTAAPPPPPTPVVAAAAPPPPPSLSCTACAASLKATQKFCPKCGAPSAPAAVAAPSPPQSTPPPPSSSSSSCCMACLAPWNGISKFCSKCGAPTASLIASSTPAAVPTAIAATSSRACPQCGFQCKALAKFCPGCGHSFGVATVSAAQRQADDDEVRRNLAQAQAKLEAQRQAEQSQRSFASSLAAQAVATRPNPSSSVRSSHASWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WFM7</accession>
    <name>A0A6G0WFM7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">endo-1,4-beta-xylanase</fullName>
            <ecNumber evidence="3">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_016287</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000248">
        <property type="protein sequence ID" value="KAF0725202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WFM7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014196"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490:SF88">
        <property type="entry name" value="BETA-XYLANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026355686" description="endo-1,4-beta-xylanase" evidence="10">
        <location>
            <begin position="22"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="GH10" evidence="11">
        <location>
            <begin position="27"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0725202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="317" mass="34942" checksum="54179AFF16C93C15" modified="2020-08-12" version="1">MQFLSVVRWTIAALFVQNANAVYFGTATDRPSNYGSVVPDNFNLLVSENGMKWDAHEQAKGVFNFQNSLNEIAYAKKNNMKMRGHCLVWHNQMPSFYCTAQGPGDTGCISTSLSASQLWSAIETLIETRIQKTFAALSDPTIIAWDVLNEAVSDDGSGLKHDVFYNTIGPDYVAKIFTLARIYAPAGVKLFYNDYGCDTPGAKANQCFNLVKGLKDKGLIRFSDICVTIHMTEMDVGGSNQQTQATVFATVATNCKANPKCEAFVVWGVSDKNSWRASETPLLFDSNLKKKPAFAACANVIKGRRLLRGEPLEVDQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WFY9</accession>
    <name>A0A6G0WFY9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_015769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000232">
        <property type="protein sequence ID" value="KAF0725804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WFY9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001876"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0725804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="171" mass="19182" checksum="8E013D32E9C0A4C8" modified="2020-08-12" version="1">MHRSCNRSSGILHRAWYSTKISPTIRVATTADIDAIVDLTYTTLRDAKMLKGDRTSAFHVASLLDKSQGGVIVAEVDNEIVGSIFVEKPDKMYALTMRKDWREQDIGSQLFRRAEVYAKQMLGMAKVQGPVLTTRTDLFEFYERLGSIRTGIIFDHPEGGGLQAEIVMKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WIG3</accession>
    <name>A0A6G0WIG3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_014869</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000203">
        <property type="protein sequence ID" value="KAF0727004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WIG3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013003"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0727004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="147" mass="16903" checksum="44D4431C697E0760" modified="2020-08-12" version="1">MSRETISRLIAASTEESNNLHRANLLFEQPVREVEDADPMDVPSAFDTPILDSYMQAGSEALLTLTNFTMTEFNILCGLCEEDVQESWYDGRGRQNSASAKDVFFMLLVVMKHYDTWERHALDFNFRTPTFEKLIMRIMALVEPILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJH9</accession>
    <name>A0A6G0WJH9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_014647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000198">
        <property type="protein sequence ID" value="KAF0727389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJH9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017212"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01518">
        <property type="entry name" value="RHOD_YceA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00469">
        <property type="entry name" value="TrhO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022111">
        <property type="entry name" value="Rhodanese_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020936">
        <property type="entry name" value="TrhO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040503">
        <property type="entry name" value="TRHO_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43268:SF7">
        <property type="entry name" value="RHODANESE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43268">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE/RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12368">
        <property type="entry name" value="Rhodanese_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17773">
        <property type="entry name" value="UPF0176_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="129"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0727389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="347" mass="38555" checksum="9A8132BFE806C23B" modified="2020-08-12" version="1">MPTTGPFQVVLYYRYVNLTEDEVEATIAFQQDLCASLGLSGRVRLSEEGINGTLGGTPESIQAYIDAMASQPFSDVDWKLSTADELPFNDLLIRRVKEIVSIELPDDECRVSDTGIHLKPEEFHAALESTANAAVIDVRNNYEFNIGHFKNAMNPSTRRFGQFPQWVRDHLEELQTKDSILMYCTGGIRCEKASAYLKHLGLSNVYQLQGGIHRYLEAFPDGGAFVGKNFVFDQRVAMSSSNDQVVGHCQGCDSAHDVISGIRCSYCRMHVMLCTACDDKLDRPLFCHDHEWMGQGTVDDLALKLAGLESKLTASIGPKEKGHRRSIRKQMDAIQASLDAIQKAVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WLI1</accession>
    <name>A0A6G0WLI1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription factor TFIIIC triple barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_013965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000181">
        <property type="protein sequence ID" value="KAF0728139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WLI1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018803"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042771">
        <property type="entry name" value="GTF3C6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019481">
        <property type="entry name" value="TFIIIC_triple_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21860:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21860">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIIC TFIIIC , POLYPEPTIDE 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10419">
        <property type="entry name" value="TFIIIC_sub6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor TFIIIC triple barrel" evidence="2">
        <location>
            <begin position="29"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0728139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="128" mass="14796" checksum="6DC51318F2B217E6" modified="2020-08-12" version="1">MSRKRTLSDANGETRKEEEKEEESPAEDHDSVYISVELTDFADYPILDKHETLEIENLESDQPILRIGEYVLYGKYEEAIGTDLYYDMQLKGDTSATSCSFVGKATKRLKFAIDPKEQRHFLRKPTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WLN0</accession>
    <name>A0A6G0WLN0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_014010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000181">
        <property type="protein sequence ID" value="KAF0728184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WLN0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005132"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16982">
        <property type="entry name" value="CID_Pcf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045154">
        <property type="entry name" value="PCF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047415">
        <property type="entry name" value="Pcf11_CID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057242">
        <property type="entry name" value="PCFS4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15921:SF3">
        <property type="entry name" value="PRE-MRNA CLEAVAGE COMPLEX 2 PROTEIN PCF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15921">
        <property type="entry name" value="PRE-MRNA CLEAVAGE COMPLEX II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23228">
        <property type="entry name" value="zf_PCFS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="2">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0728184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="539" mass="59692" checksum="B78D1603DCBE6D84" modified="2020-08-12" version="1">MINELGAYPAKHIINSLTMIAEDLTIAKHLAPFLVKKLNLVGPAYKLPILYLMDSIIKNVGGPYAHFFSQTLAPVFVAAVQVVNPTDLNRFNHVLKTWEAARLIPPPVLAQMRTATDGALRTAQPADQPTSFSKVTGAVLPTPRPASRSEDSQLELQMRQLLRQLQTDDGIHPTEHLSLEEVRARNPEMYANLKLTCHQPAPAPIPEPVLGHRPIQPPLRPAEPLLPHPSRSEPRFDRTGGRGGGGGLLGPPPPQSVTQPPPSRRPVVSRSPPRSRIHRDVSGPPSTTSTASSRPSAPSQRDVMKLLKKINTIASNPVRPLTCSEIQVNKKRIDANVYSLYGALPEVCASSGLRFNDKAKLSEHMDFLFHYNRALRERTKGGISRSWYPNEEQWSTDFRTVSNSKEETSAGFVQKEDDIDMGNDALNSARVAVDASITKCRICGESFTKCWDEEEEEWMYQNAVVGTIQVDAAVYKQTIFHKYCYDSAVASSKLSAILPSQLAPGSPMVPLKREIDYDSEQVQFNKRLKPSDDMTAHEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WNF0</accession>
    <name>A0A6G0WNF0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_013438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000172">
        <property type="protein sequence ID" value="KAF0728869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WNF0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010771"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03109">
        <property type="entry name" value="DTBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.20">
        <property type="entry name" value="HprK N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028979">
        <property type="entry name" value="Ser_kin/Pase_Hpr-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21343">
        <property type="entry name" value="DETHIOBIOTIN SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21343:SF8">
        <property type="entry name" value="DRTGG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13500">
        <property type="entry name" value="AAA_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0728869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="374" mass="41841" checksum="21EDF337F441D5D5" modified="2020-08-12" version="1">MKNAVYVAATRQHVGKTSTCLGLLQGLTNRFEHIGFLKPVGQQSVLVDGNLRVDKDVRVAKEVFGLSRCDYADMSPVVIPPGYTRDYLDGKITLESQLDKIHKSFKRISERNEFTVVEGTGHTGVGSIVNVSNARVAADLGVDMVLIANGGIGSTFDDLSLNRAMCKEYGVRIRGVILNKVRPDKVDMMWDYFPKALKQWDIPLLGVVPDLPLLAQHSMMDYEDLFHTELLSGHARRMQQYKSVNLVTSGLRRFLVELSSNEFNDTLFVAHASRNDIILGFLSHSQNFELKTGQEFGGGLILTGLPPKDQPQEYMMDIISRTHLPVLYAPYTTFEAMDMMGSFTAKFNATDVNKVLSCAKHYEQCINFDALLRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WPW4</accession>
    <name>A0A6G0WPW4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_012921</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000164">
        <property type="protein sequence ID" value="KAF0729420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WPW4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007979"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0729420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="380" mass="43745" checksum="BDB617C5C53AAB62" modified="2020-08-12" version="1">MSYGISPVELKRISQSNRDRKYRAKKKLEHKRLIEELETLQDQHETNKFASLIDEITSNAELEAIRLHDSLTQNQTLRANVDRMNVVCKLLHDWVRSLKPSKRITPKGSWLHSTLLAHPAARVHGYKWFSDRIYHAADSLLSEPPFENSVEDEMQHIMHTELDEDGLRTIGANELRLQRTHFYDFKATAHLFWNYIILNNFVTSSLTTSSWIADSVDSKLVYHCVVNEQTGTTLRRILRMYEEPNRVVITFASIANDECYPWTDSELRTHGYAWAIFERVSDSMTIARFSTVHSAPITPKGAASLEQIGQIYGKSAHGIEHREAYIEHVRAIAEKVYLTGFRQLTDAFAEIVIQAATQPPRGEHDDDDYAVEFDLSRFAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WQ69</accession>
    <name>A0A6G0WQ69_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb/SANT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_012840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000163">
        <property type="protein sequence ID" value="KAF0729572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WQ69"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005737"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024752">
        <property type="entry name" value="Myb/SANT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46929">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46929:SF3">
        <property type="entry name" value="MYB_SANT-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12776">
        <property type="entry name" value="Myb_DNA-bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like" evidence="2">
        <location>
            <begin position="4"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0729572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="302" mass="33949" checksum="B212ECB019B14E98" modified="2020-08-12" version="1">MTLWTQELDQVRLNEMIHQANVLGKRSNSGFKKEAWAAALKKLNMKTNCSFTMPQLKSHNATMREHYSIISTMSDASGMGWESERCMVVCLDTTWDAYLATKPKKYQQWKNKPFPLFHLCESFYKGTLATGKGDRVAGNLNHRATSYISDDCQSEAKQDALLDVDFGQHRPRPEFDLDYSDRDDSMASSRRAPPSPQSPPSKRHRGALGSDMLVEMKKQKEDTATQFEVLCGLLKSSPSGASKTLTRTEQAVGILQTDFEAMPMHRLVAACDVLEVEANASVFLQLKGELRNAWLEHKQGPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WQS0</accession>
    <name>A0A6G0WQS0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_012652</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000161">
        <property type="protein sequence ID" value="KAF0729761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WQS0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010866"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0729761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="489" mass="54772" checksum="3EF3A0114E138099" modified="2020-08-12" version="1">MEDIPAQFNSPTKVIELTPWEHVRLDTLEGVAKWLENGAYPEPFLGWVKQFGNAVRLRRLLSYSIMITDPKAIQHVLSINSNNYHRTDFVEKFLADFTFGPGLLSTRGAVHDGYRKMLNPLFSAGQIKKFIPIFEAQARHVCDTILAQAAASGEPINLYDVFSDLTLRVIGMAGFGFNFEDHPEAHEAYQMVQQDVTPWILLGLNLIPGFFDFPLPGFIRRRKAQVTLRRVVNEVIEQKLAQNNADDKPKDLLDLILPNSTTREAVIHTMTLLSAGHDTSSGGLSWIFASISSRPDVIQRIREEYKTVIAKHGSLSTWEATSQLKYTMAVIQETMRLNGVLFSLGPRVAVKDDSIPMLDRTPIFIPAGTEVSINIAALHRHPKFWTNADAFIPERFLEGTPEWDVDLKLRDGKSHAFYYLPFSFGSANCIGQRFALAEIQVILAMIVGEFDFKLTSAADLRQKHNGVTMTPANLQVTIERAPNAPVPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WRA5</accession>
    <name>A0A6G0WRA5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Aquaporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_012476</name>
        <name evidence="11" type="ORF">Ae201684_012477</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000158">
        <property type="protein sequence ID" value="KAF0729987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VJMJ01000158">
        <property type="protein sequence ID" value="KAF0729988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WRA5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008678"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015254">
        <property type="term" value="F:glycerol channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050363">
        <property type="entry name" value="MIP/Aquaporin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829:SF9">
        <property type="entry name" value="AQUAPORIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02019">
        <property type="entry name" value="AQUAPORIN7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0729987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0729988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="31572" checksum="072FFA1D2673A1A1" modified="2020-08-12" version="1">MPSYKASNSNQWWRIRNRLARECLAEIAGTFIMMILINGVSAQGALGEGKKGGFTETALGCGLAVMLGLHTAGGISGAHLNPSISIAMAVYGKLPWKKVPFYIVSQFVGAFVAAYMVFLAYYPAINTLDPDRTMKTAGIFATYPASWENNGSAFVNEMIGTALLVFTIFSVDDPANMPTNAMMKPLTVGLIVVMLVQSFSLSTGATLNPARDLGPRVLSACAGWGSQVFTLYANYWWVPICGPIVGAILGGGTYMLFIFNHHDQDDGRPNNNYNAAHDDYESDMTSPVVSVCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WS69</accession>
    <name>A0A6G0WS69_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_012266</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000155">
        <property type="protein sequence ID" value="KAF0730265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WS69"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009433"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001650">
        <property type="term" value="C:fibrillar center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001164">
        <property type="term" value="F:RNA polymerase I core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038801">
        <property type="entry name" value="TAF1C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15319">
        <property type="entry name" value="TATA BOX-BINDING PROTEIN ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15319:SF1">
        <property type="entry name" value="TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0730265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="709" mass="79408" checksum="AEF2004C1E5CFE1B" modified="2020-08-12" version="1">MWEYGLPNFSREYIEMGLNRRVSYTLPGRIPVDAVRLLNASSVRERWECIGLPELLERNTVSYPYHVPNTRLNWASRMRADLRDPEKRATRDANQFQTRFKDAGIPKDLLTSLIKQENKIQENNQVLRSDRQGNALKAVEWNDRHVVYYPTGELLHKLQCKRRRRGQSHWKTTCEAFDLINSIQQIETFGSPAHYSTTPVVITRGASNCNVVTFDSDLSIESMDKISFPEMLYHVCTSPHVEAEAACLGTTGKLFTWTPQGGIQVVGHAAPLQRWIRSEYSSHPCVLWTANRHAVGTYDVRLPAPEGFNTDWIIDFLPSTTEIVDIKRHPSCPFQLIVRTDASIDILDVRSPSKSVIQWKHAGLYTPPEQLPTPTTIGTIDVVDVSTPEQDRALIVSGSSSTNKVSVHWYNGNTSVETTMQRLSAPHAAMMNQAAAGDAAFDIHLADETPWIHQIGVCVVGRSSTACDVLQLSSLGDLFLQTLELTTDPIQFQDNLRSGRTARDTTVNDPLAPLHPPVAAKAFLPSYDATSLQPFRLLSVDKVQRALAPVSLLPSRALEINLEDHFAPLAPSCTLYALMQTWQTSRPSYERLAEAIDFSLRLNLRFVQSHGRHDSTSVRVRHLPGARPTKSICGCAWTKEALPCEHVDCPLPHAWIVHETSYATSVQTTRPLPPVAKGSSHAQIVKDLEAVYGKTVDVPSSPRRFKKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WSN4</accession>
    <name>A0A6G0WSN4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_012146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000154">
        <property type="protein sequence ID" value="KAF0730446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WSN4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015944"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37031">
        <property type="entry name" value="METALLOPHOSPHATASE BINDING DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37031:SF2">
        <property type="entry name" value="PHOD-LIKE PHOSPHATASE METALLOPHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="344"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0730446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1116" mass="127742" checksum="1CC0B45CB4AD64D7" modified="2020-08-12" version="1">MGNAESCRALQTELEQLESTLSVLAATNPIGRRPLLPHHIEFKGLVLGCRKDVKVNVGPIVGAVGLDYARILLEVDATTSIACHVSRQDERTGQWLEVERSRVQVECVKNRPSLFHMTRLRPDTRYTFAFSGLNERDATSRYGTFHTLHVSDAPVQIGAVSGNNVYDGDNIGGWERLAQVVAGNEEVAPTVRPPVHYILHLGGQIHMERTFQQCWVLLSRYVQSTTPQASWEEMEAKVVERMRDAYRFQWSLPHVRNVLANVSNLMLWSDQDIYADFTCSEIFKANHESPTIQMQIMRTLLRSARLIYHEYQRQLWDANYSEFYKEMNELVKSSEAAINATVTVHRSRQEIEEVEKTLATAKRKMEFDVVKRCESRMNELKAKIEQLQKEFVKLREQIDSRRGEEYFFKTDSNIGFLMLDMRGSRLTPAGAQSPDNPILSPAQWDYVLSALGDTTVRLLVICSELPIVDDSNANITNALAVHESASVCRSWWGFTPRDQERLLALLSEWKLQRFDSIDTKMRTEFNQYTVGPIAGPLSTILAPSMTGDVGESQRFQYQHTLELPQENNFAFLDLSALEGRDPVFNIQRFGQIASQVRVLAGPVMGVVDSQSCVILLEVDKEATIGCVVKNIVTSEEQRLLQVFSAKTPQSFYFTHLRPGQHYTAHFEGLEDSKLYCTFHTPEKSPTQWNMILVSRDMQSSFSSNEKTSHNLWSTIGASISQPFSSVNLVVHLGGQVVAPSNPSVDEALALLKARDINDPTTILLVKEQLRSIYRDHWNLTDTKQSLMCGSHIMLWNETDTLDPYEHRHDEHRCQLAKILREVAKEYQDQLWLPNSSYTHSWGGFGLYVWQKEQEQDGICERWHRLDNLLKQPISTLVIASDQPLIDDSLEDTREKAKFNSMYTNRIPYRGVDLLKLLQLIFEWKGTSNKQVVFICGNDYFGFDTVVQHVVSNVIIRQFAVGPLFSQFTKEMLKTITYFKEGSLGHLCIYKHNFNDAYLTNHFGFISLQENQVEYEIVGILLPSEFPENNIGDKCQTRDALQWYRGGGLPSMLSKIQLSKGWNKLRPFSMAKRSNGKMPTQVAVNRWRSQEIAFMFQIPCIVAFKDFLRFVVWNYVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WSX0</accession>
    <name>A0A6G0WSX0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cysteine/serine-rich nuclear protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_011948</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000153">
        <property type="protein sequence ID" value="KAF0730525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WSX0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015892"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031972">
        <property type="entry name" value="CSRNP_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16019">
        <property type="entry name" value="CSRNP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cysteine/serine-rich nuclear protein N-terminal" evidence="2">
        <location>
            <begin position="35"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0730525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="151" mass="17406" checksum="556E681CCCDB8959" modified="2020-08-12" version="1">MPETTCLSWPTLAPLCAPTWTPVAFLPSKKTFPREKQVSFTTVTTYTFPLEYGGSAIPSDHGPPIGLAKVHSRQTCHHLDNVKDKRSRLRKFDHMERMILLQEKASYTRKEVARFCFESIVVQKSRQDTRENKEEEAEDEQQTAPKRRKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WTR3</accession>
    <name>A0A6G0WTR3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase C1A papain C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_011776</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000149">
        <property type="protein sequence ID" value="KAF0730894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WTR3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007400"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026352279" description="Peptidase C1A papain C-terminal domain-containing protein" evidence="4">
        <location>
            <begin position="18"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="5">
        <location>
            <begin position="134"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="349"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="368"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="388"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="435"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0730894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="643" mass="67579" checksum="08BAA3052484D987" modified="2020-08-12" version="1">MKASLFFFSTLSTSALARMAYSALSVDEQADVKSQLSKWKTLFAPIAKEHGYLPSSSTESATLVDTHSDDELARFHNTLQDVAKAQQNNPQAQFSPFNVFALLTPAEFNKILQNSYAGQNLTAATPLTEDATVSDASVDWSTHKCSSPVKNQGQCGSCWAFSTIGTTEFAHCLATGELLDLSEQQVVNCETNSKGCSGGYTLKALDFERQGVCTEESLPYTSGSSGQAGSCQSSCQKKQLTVGEAGHTTGEASLVTVLNSQPATVAVSSSNEVWRNYKSGVVTQCPDGPLDHAVIAVGYDKTSIKIKNSWGAQWGDNGYIYLQRGGGGDKGMCGVVQDIVYPKVTKAATAAASSPSMSSKSISTGSAPTSVQSNQWLQRSAGHGGNNQGYQPNSPNNGNRPSHQNNFPRPTFSLNRPPRPTFPHNQHSRPPCSKSPSPTTPFTDTPSTDSPFPTDSPSDSPFPTDSPSDSPFPTDSPSDSPTDSPSDSPFPTDSPSDSPYPTDSPSDSPFPTDSPSDNPTDSPSDSPFPTDSPSDSPTDSPSDSPYPTDSPSDSPFPTDSPSDSPTDSPSDSPFPTDLPSDSPFPTESPSDSPFPTDSPSDSPFPTDSPSTDSPSTDVPSTYSPPSDAPSSSMSPPTPAPSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WUA4</accession>
    <name>A0A6G0WUA4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_011587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000147">
        <property type="protein sequence ID" value="KAF0731038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WUA4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002037"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45023">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45023:SF4">
        <property type="entry name" value="GLYCINE-RICH PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0731038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="185" mass="21414" checksum="8C283A442959F1FE" modified="2020-08-12" version="1">MAQGKKWSEDDDKALVAAWIRASENNIRGADQKTIEFWDAVYAHFQAQNRPARSRKAIRNRWSTIRHDVSKFVGVFSQAERNARSGSSPDDVVATAIAVYKERHGSDFELMHCWQALRACPKFSTPKRKEPDDEKIEKVRIGQKKAKQIEVEKVQRTRELKRLDRIASALEKRNKIMQLQILVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WUM5</accession>
    <name>A0A6G0WUM5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ae201684_011431</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000146">
        <property type="protein sequence ID" value="KAF0731165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WUM5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019795"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.630">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003938">
        <property type="entry name" value="K_chnl_volt-dep_EAG/ELK/ERG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050818">
        <property type="entry name" value="KCNH_animal-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10217:SF435">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN EAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10217">
        <property type="entry name" value="VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01463">
        <property type="entry name" value="EAGCHANLFMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="14">
        <location>
            <begin position="420"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="581"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF0731165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="713" mass="81347" checksum="D7B6513D507ED4D0" modified="2020-08-12" version="1">MLGVNRGFKPVGPSVPLARASFPTANRARVHPKAKRPLNRKFQTSMTLTSQYFNRFIGSGKGILTSTTKQLPRRHRWFRPFHPHSQQMRNWGIVSIVSIVFTAIVTPFETAFTTTSLDSWLFYVNRCVDLCFLADAGLQFFLMYYDEANSIWVSDPRKIARKYLLGWFGLDLLSILPFDVVGLALANTTVKQLRFTRVLRLLRLMKIIKVLRRATSIRLWESKMVVNYATVSLVKFCLIVLMTSHWMACIFRMVVDIEDYFDSHGVKMNWMTEHNMGGAPIAASGMGIQYMSALYWSSMTLTTIGYGDLVPTTPGERALAIMCMLIGGGTYAYVVGSVCQILNSMDASTTEFHQTIDTLNEYCRHNKLPAELSSRLREYFHSSRTLLRERQHHNLLLTMSPGLRGEVALYNNQWIANIDFFNCSSAFERSQFITAVALLLRHECFPPNEYVIREGEYNTKMYLVQRGIATKGKVMYSGGSFFGEDIILTLRQRRAAVRAFSYLHVQVLSKFELEELIYSGLYPEIQRNIRRQVLKAAFKNNFVKLSQDTIRRRSTQSPDALKQSLMVKFLSMEPLDDTLHRQNNDRRLSNGPQSPQSHPKYPLYRAASKTEPTKTEDDTVDTIIDSVSTLMDANIAHHDKHLISKLDEILARITRLEKYVTPNVIYPTSAPAHQAHERSDSAVLLQAVQELERGEARSLAKTASFKRRTSCGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WVK6</accession>
    <name>A0A6G0WVK6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">6-phosphogluconolactonase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_011143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cycloisomerase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000141">
        <property type="protein sequence ID" value="KAF0731517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WVK6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007370"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050282">
        <property type="entry name" value="Cycloisomerase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344:SF1">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0731517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="365" mass="38426" checksum="265A995840EECD9B" modified="2020-08-12" version="1">MTSSTLVVGTYTRKEGHVDGKGKGICTIKVSHETGELSLVHVNEDVGVNPSFVIARSATGHVIAVNEDAYVTESHPQGTGYVTSFSIDDAGVLTFQSKQPSHGSYTCHANFDPSGRFVVASNYGGGNIALYPISPEGVLSPATSVVQMTGASLANPQRQEAPHCHSSTWITPTILAVMDLGNDKVMQFTLNTATGVLEPHARPHIVLPPGSGPRHMGVHPTKPLAYVVNELSNTLSVHSIDATDGLSEPLQIASILPPESAVDGTTLAAEVHVSKCGNFVLCSTRGPNCIAVLRITYPAGHVASPTFVSSNGSFPRHFQLVGDDLVLVANQNSDSIFSFRLTPAEGLKPTGHQLNIPTPVCLSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WW41</accession>
    <name>A0A6G0WW41_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_011065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000140">
        <property type="protein sequence ID" value="KAF0731763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003078"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0731763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1281" mass="140370" checksum="04C4EB53425F4C6D" modified="2020-08-12" version="1">MTWTERDDDLLRQCVFECAYDFDAAASMLTMRLPKQRKLALGDISPQVCEVEYQRLCEQDECAEDEDYDQHDEDGLGECITERCSTKKHVDETLNVPVLELSLSEGDVDCLLLDIPLVATAADDSSEMQWVLAYLEDPANTVDESDAIAFDSSVYSAKGDDCLAQLDHAFQARAAHRCNYDDNAFAPLPTIEKDNTQVTRAPTPVTSLTPDSKPTGEVDSVADDFPGQVNVQPPPVPLCPSSHLGLTAKSPDSEDDSSSDDEWESTRRQLKERTCHAAGATLAQECSDSNDTDDNVDDDIPLDPSEAQERELMKQWKAEVERQERELEFIFPASETTPVIHLESTLEQCQALSFGAPNPFALDENEAPPFVATPLPVPLVKAKTPKTPLATTAAAANADKFVKQEAISKPILPKQRQEPDHNMENERRLLIEQSILKANHLHEPLYHRELSFTPFVPTLPAPYWHALFCYGKSSEDCETLSMENVHVVAMTTDSTSDEFGLLVELFCQLYTQNASCTLLGLQYTVALPPLSTPSLRPTRQSHDEACRVLYIALQCDAAHLDAIFRSPMSSFVPGHSKCVGDYLTRVVLPQNEAIHLFTRLPAFDIFHQTLLCPRVALGTSAPETSVVILATPHAHLRQIFDRTRHDLDLVGLKLCFNASFEPHVVVTREVSTAGCHLALAFRGACATTRLRESLHEVPKTAVYIPHGPLQAKRDVVYWFGGRIYDGVTTQVHVPRPHPVYGIVLKREEIVSVNVHAAVPQLGSVLAAVAATGYDLLRMSRSPRGLNLKLTKEDGGNELYIQALRAQLALATPNDSASSTEIVIQRMDGLDALDDNESLLSPVETLPCASSFVVDFEREQTILAAVFLDASTSGSLSPMLDCLLEGCKETQLIALKLVRGSALELLRSKRGVSFGSSAELTSSHALVVVFRQLIDDGNVKKHFAGLPQMAAVVYVDPFVVSSLLQTLFQPCELVATPPSPLDLCFPPPHGLFQLAPSTPLLSCLVLKPTASDTPMTSSILPVVLRRLERDNFGVVSMVMTTAPPPAFDTSIAGSSPSIVLSLRSLNCISRLQKLVGPDDPAIARQCARFSLIAGYGVDQTHNVFYTSRSYTQASKDVMALIPSFDKCYSDFSTHGIIATPTIAVNPRRVFVQTPRTLVETTIAVVADTPVGATLIERVVADGGFKLANIYQGQLTFDQMLYVSSHGLTTRSDGIYLVLALERDNAVSRLLTWIVGSKLFPPTSEGGSPWCCSNSAKDAMHEVPLFFHELHDSVHSIETITTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WWI1</accession>
    <name>A0A6G0WWI1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_010864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000138">
        <property type="protein sequence ID" value="KAF0731911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WWI1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006411"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="219"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0731911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="457" mass="52698" checksum="34CF2C1023616721" modified="2020-08-12" version="1">MAYIINQLRVTVHETNEYKQLVATHEDAVSKWNASQMAFEDQLSRAHEQLELINKQLVDALVAKHQYAYEIESLQSILRRCIQEREVSNVNKLVFPSNMNANKQNDHRAQLLVAQSKSKLANVEQQQSEIQYEYQENSQLARQLAAVQSELSKTKHDLRIHEQSECDLWGEMHDYYQIHHTRHSVSQTTVETLTAQITRDSQIVHGLDFGVQSGSQTQIKAMQEMIDQILEENEVLHNENKTSDTLQQALQAKLREVNSRNDFLRTQCDDHESKIKDLESKLHEVQRAKTIWDCAQPDDGASTIYKTTHAQDPKTMTQFQREGDTNDKLDDEDQMPEAIIFLPRCTAMAQDDDEAVGACTNPVSDASSNISNLDPSARKETLILFNDARRTSPMLHIWNFKSNSYNIPRWAILIIKSTVVKQHRKSCDANNKNKFKEESRRDRFVETSTAMSSQIWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WWJ2</accession>
    <name>A0A6G0WWJ2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein-tyrosine-phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_010962</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000139">
        <property type="protein sequence ID" value="KAF0731863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WWJ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013948"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
        <property type="entry name" value="FYVE_like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000109">
        <property type="entry name" value="Dual specificity phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF519">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE MPK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="9">
        <location>
            <begin position="158"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="10">
        <location>
            <begin position="222"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="9">
        <location>
            <begin position="549"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="10">
        <location>
            <begin position="619"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="11">
        <location>
            <begin position="725"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="350"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="894"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="353"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="908"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="958"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="992"/>
            <end position="1005"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0731863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1098" mass="123533" checksum="D0D3448237A5907F" modified="2020-08-12" version="1">MAQTSATISSSPGLKTIPNPNGTVFGDQSSQVAFNPDAPALVATPADVFNFLQHSAFSTLILDISSSFEDLPPMVLPVTFSKDGVCQFPELVTKRLANSALTHVFLTENTKLPDTKVRRAKVARTIGEVRGKGSPLDVQFVDVALISLFPLQEPPEVNLVESSHGWIFLGNNLHAKNVKVVQTLEVECIVNCASSSQEKLLQDVEYFDLKVPKENAEAGAAIAFDEAVDFMVQAFKRYRRIMVHSTYGRSRCCTLVVYFIMKTENVSLVEAYHRVLKCRPQMMPRDAILDLLVQKEKSLYGKSSFNEADKSAFREKLKQLCRGDLLSQGDKEKHNSALANINNSEVKQLAAKYQQSSKESPLTNDKASKTTGNEALTSTNTKRRSVPESIVTCRWLFNRLQSGTGMLLIDSRSRYDFEDDCVPTAISIPSLKQPCTMADVENALLPEQAHLFSIKKRKLREVVIYGDAVKSVAVQENFSKGKPWMYVLGGLLVEEALVTSVRYLEDGFTTFQFRYPFYTTLFLFDCHNNDDEHGNLLARTRSGTHNVNYPNEILDGFLFLGNMWHAQSPSVIRNLGITHIVNASLDTDNVFDEAGVIYHEVKIKDDVNADIAAHFESTYSFIENAKKVQHSRVLIHCTQGISRSCTLAIYYVMRAQRWSLVTSVNYCISNRGVCFPNQGFLQALMVEERKLYHANSLSTHEMDLLVGNSLSDRPVPKPAPLEPYLQKPENCHVCKRLFSFFDWRHRCGICKVTVCGKCSSSRLILTEQASGYDKNDVGRVCDPCVTHLWAMHLPLPFRLAFNIFSDKYGMRVRRSLAVKSPSLQHQYLTVSYIPGTEAHILMNLLRKRFQVRDYELLDVTGDGVGLDSAWSLQSGGYLDLPDQAVLFASVGESGSISEPRGASLRGAFTSTTGSSYRNGIMRQEQSFTSRSLPSNSRHLTRRSRSFSEGRALALQQSLRERERQKKHDQVYHHSLPGTRDGQPRNESRSRSKNASIEGQRGMQSPSMMDDIRFAELWGAAYPYCSLIPRDQLLCLDKETMMELMLAISYLSSRVGHYTTNVDSNARQNDFSEVFETMKMSETTRQIMLQYIEINPTNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WYB1</accession>
    <name>A0A6G0WYB1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tudor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_010396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000131">
        <property type="protein sequence ID" value="KAF0732499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WYB1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021594"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20379">
        <property type="entry name" value="Tudor_dTUD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37827:SF1">
        <property type="entry name" value="HNH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37827">
        <property type="entry name" value="TUDOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tudor" evidence="1">
        <location>
            <begin position="116"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0732499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="274" mass="31235" checksum="A8B01E91E9006739" modified="2020-08-12" version="1">MSKSKMTSPELTPELVQSALAASLTNTHDSDVLDYLVELIVEAATEAQTKALQSKFKKKRALTLYDFLSRAVEDTLLDAETTLGEDDIVAVIETANAYLHAKLYPKEEMLEQDNHGYNVGAHCVAIMPEDDEWHEAEVVSAEQLHTKQTIQLRFVEFGNIHDVKVSNVVLEENIVEDNAAKVCAMCERPVNLTEHHLIPRQVHARYLKKGFTREFLNRCIDICRSCHSKIHSTEDNRTLAAEYNTLEKLMAHESIQKYVNYARKQKPRMRIRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WYL0</accession>
    <name>A0A6G0WYL0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_010377</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000130">
        <property type="protein sequence ID" value="KAF0732670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WYL0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020158"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37558">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37558:SF1">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="191"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0732670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="27756" checksum="03F14189823D06EA" modified="2020-08-12" version="1">MASILHSTSNPSNGTPPGISSPGQDVQEDDWSSGRSKFACRDDVVLLTQVVLASPWAAGHKKVMAAWEDIAKNCARQPGFGLKTKKGPALKTRFSLLLETFKKGEMASMRKSGATEEFEEREILLTDIKSRIDDYSEVEEARKEINKKKKDGIESSGRLLRQLAMDESVESSCRKRRRSSPTKNDVVEGILATIKESIAEKREREERLLAEQRERLEFEKAEAKANADRFAANQEIMLSLISAILKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X0C4</accession>
    <name>A0A6G0X0C4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_009802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000124">
        <property type="protein sequence ID" value="KAF0733238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X0C4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005385"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15457">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.40">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012816">
        <property type="entry name" value="NADAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037238">
        <property type="entry name" value="YbiA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02464">
        <property type="entry name" value="ribofla_fusion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08719">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143990">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADAR" evidence="1">
        <location>
            <begin position="36"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0733238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="188" mass="21233" checksum="85B285097C874C1A" modified="2020-08-12" version="1">MALPTSREELRAAMDRGENFSYLCFYGHKPPTDGEVTKSCFSQWFDAPFTVDGVHYPTAEHFMMAEKARLFKDDDMLEEILASPNPATAKALGRSVQNFDESIWRKHRSDIVVRASIAKFDQNPAMKAFLLGTKKHVLVEASPRDTIWGIGYGAKNPKAEEPHNWRGLNLLGFALMIARDTLKEKEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X0M7</accession>
    <name>A0A6G0X0M7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_009676</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000122">
        <property type="protein sequence ID" value="KAF0733430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X0M7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001782"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KLP-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972:SF28">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KLP-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3 4" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="7">
        <location>
            <begin position="258"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="224"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="332"/>
            <end position="339"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0733430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="599" mass="67623" checksum="B9BD854EAED923FE" modified="2020-08-12" version="1">MHRISSNDDKKRDRSLSMSLSSSSYVSPQRRQPKKKLMLDREKLLDMNQVKAAIDAEEYPETPEYFRQQRRRMPQVPRVSPLQTKTTAVPILEQQSFLQTRVHTLTQALIKANLHHKRTQEHLTWALEEHATVQFEKQQLEQQLSEVMTSTHMNGHRVIQPSGLSDNISEQAELLAEQAHHLRVENHELKMAFMSEMQALQASLGQLTMSWRAQQQSQARAMKSRHHEQEITALEAKCNALMAERKLLHNTIQELRGNIRVFCRLRPVGRTQSAVRVESDTRLTIQDSGVESAFIVDKIFDQASTQHDVYVEVQPLITSAMDGYNVCILAYGQTGSGKTHTMMGSLHSDANQLVALDHVEYDASSSRGLCTRVFRDVFNQLHGDNNQSEVEVHISCVEIYNEKLVDLVQPSPTPLDVRMDKKSGVSVPNRTWVAVSKVDECVLVMEKALRHRSVAANDLNDASSRSHCITSLKVRRTDGALVMESKINLVDLAGSERLGTSNSEGERRSEATHINKSLLALRHVLLQLKNKQEYISYRDSKLTMLLQDAIGGHAKTLLFVCVNPATKCALESKCSLAFGERTNSVELGKAKQNVTKLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X1W0</accession>
    <name>A0A6G0X1W0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_009334</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000119">
        <property type="protein sequence ID" value="KAF0733764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X1W0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000577"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0733764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="554" mass="62131" checksum="55D460214838620B" modified="2020-08-12" version="1">MSLVVVGETDPPQTVLRARTLEPRDSDGSFHVVDMSPLDFIKTFGKTEERELLRHMGQAYLGSWKKPSKYAIQEMVFGWVNRTVTSAKKWQQKWKNRLARIDWHEKWEHVTNWTAHFNASREIEMLKMSFMTFDQVAQYLNITRPPPATTEATWDPLAPFTASSYHGPTTYKHVPATVAKRFEPFQEYALQYYAPSTANPLLPAEDYPWTWNASIVRIKSLLESSLLNDTNQTNATNKTALSLFDTIERLRQPFHIMSGLPVILEDIPLHSILPFPSPSDALADGKRYFYGYPSTSPSSSSSSSAQVWLRSSVTIYTPTLNVSTNSSGIEVELHLRRFFDLAFDADVAGLLLGLQAPSTVWLSPFDRISDEFADLCLGDLVAARERPDVPTDATALYDGMTRNSATHPSCLWNGNSRYYTAKRSSTRPFNRSAVVAAPLALYIAKRAANITEMKATMRSMRQTQIAELLANATEQTVLPVSAMGHGVVFHGANPQHVLLEVIKEPEPIHAIHRVLIRLGESSLLSWQEMDQLLACTCLHLLGMAPDKSVSACRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X215</accession>
    <name>A0A6G0X215_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_009409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000119">
        <property type="protein sequence ID" value="KAF0733849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X215"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009549"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0733849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="244" mass="26725" checksum="FBE624A4F1986A83" modified="2020-08-12" version="1">MVSMLDMDPPTMQRAEKIATAMPPLLNIPRLQTDFLPGAKATRLLTQIPVSWQLQDAPIDPVTLVPKSPIHFMNVLPQRHTEFRIQIKDALFGSFQILQVSQEKSRLNLPPPKTMMTMDSILNMVDTVAENIPEPSVEATLEIDELDALLTPRPKSIGRGNSSSGRHILGTPSTPGGRSNDAEDDKEEVRKPSKVSHHKSPGRSLKSHTLRATGQSSRNVSSFALNGKHAAKSTDEAAGHLPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X2W3</accession>
    <name>A0A6G0X2W3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_009113</name>
        <name evidence="2" type="ORF">Ae201684_009114</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000117">
        <property type="protein sequence ID" value="KAF0734252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VJMJ01000117">
        <property type="protein sequence ID" value="KAF0734253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X2W3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019919"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0734252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0734253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="211" mass="23052" checksum="1D24497F4D77B7B7" modified="2020-08-12" version="1">MADQFCVRSSLSSGVDAALTSTASCGVVFGVDCFERYKATRAFKLGVDATLVMTEPNAGGQSEVSEAMSMEYMHQLFGAVDVVTEMQIEYWSPNWKKVDYLCTIRGERVAVSVTRAMAFQGAPFDAARLLRKKMRGLVVAKTGVSRRQRYSKSVLHIWCQTTEIAMALSECYAQVADELGVTENVILIATVAATEACIFTNDASAIDVTRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X2W5</accession>
    <name>A0A6G0X2W5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_009072</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000117">
        <property type="protein sequence ID" value="KAF0734207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X2W5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017181"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="76"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="178"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="211"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="244"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="322"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="355"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="388"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="515"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="637"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="647"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0734207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="912" mass="98089" checksum="BA1A63127270083D" modified="2020-08-12" version="1">MVIIKTHDEKLYEAAKAGDIRRVRKYLLKKADPTWRNYDEAGLTSLMVAAGKGNAEAVVLLAADADAHVLNFATEEGWTAFMWAAMNGHADVVRALVDAGADTSLADKTGRRARDWAASQRHVAISFMLDSVEASKRGRHAGELREALWMAAKNGNVATVRQLLNRGGEPNWAPPDEKGWTALMVACAKGHVATVKTLLARGASVDIAASTGVTPLMCASAAGKIAIAKELLAHHADVNAINEDGGTALHGAAFYGHLAVVQVLANRGADLNMTDKTGRTAQDLAKRSQHDDIVIWLQEKEQGHLAEQQREQSQDRNLSYEASASRLFEAVKWGDVQMVQELLGDGSSVNSQDKFGRTALMEACIEGHTDVVQVLIAHDANVDLATVSGITALMCAASFGYLDVVDVLIDAGANVMLCDKRGYSARDWAELKQHNDLASVLEGAEGDVFKQERMAVLGNSDEQVDGHDLPNCTPGFQGSLGDATPLMQAALIGDLTAVDNIVSGDPDSINMTNEQGMSALMLAAIEGNTDVAQLLLRRGAAVNLADKDGHTALMHTAYCGHADMIEVLRDSWSFSFNESVYVGRTASDVALAVGHTALAKRLQYTNRIGRQSSLDIAMGVFTPRRASMAMTILESKPSPISDTASCSELSPPSSPDDSSLEDFMGLGSLSKSTSVAMKPSFPMDDPLASPWLSHETLHGLLEFKQEFLRGVLDSADKIMVPTTFIILPVHPKDPRASNVLVECIIAFLERFLHIVSCASDNATSPWTQADPPFYLYLVDEATGDIVLGDDQVYPIQVDPSSPQDYAFLSTSWPLVQAGLRWLHDANTVVGMLAAVGVPSLKVNALQTIEDHVAQIVVKIAETQLNVDAGRMFVNLLNEKDPRRTFAGLMPVSMSSSGQTLWTQRSTSTALAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X304</accession>
    <name>A0A6G0X304_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">AGC protein kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_008969</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000116">
        <property type="protein sequence ID" value="KAF0734286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X304"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001556"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05123">
        <property type="entry name" value="STKc_AGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000008">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045270">
        <property type="entry name" value="STKc_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PX" evidence="10">
        <location>
            <begin position="9"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="167"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="11">
        <location>
            <begin position="427"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0734286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="510" mass="58296" checksum="8CE17F2AF6336E60" modified="2020-08-12" version="1">MAWSLANVTSIRIPSWDSRLELEHQQRYTIFCMTVESRDSTWNLGKRYSEFRALHKMLCQRYASVRSLAFPPKRLFSSLSLRVIEQRRTGFETYMQALLAMRPRPHELQAFLSSTNDRDESVDDDFAERATVTPGGSDVGLMSDESTLFDSVRQPFDPSHKWTVDDFKVLKVLGKGSFGKVYLVQRRDAPGALFAMKVLKKRELIKRHQVDHTMTERNVMSVLDHPFIVTLRVAFQTRERLFMVSDFCVGGEIFFHLKKFRAFSETMVRFYAAELIAALSHLHSKSIVYRDLKPENVLLDADGHVRITDFGLAKRHVSLTEGAKTFCGTPEYLAPEMLVARRTKGTYGYAVDWWSLGTLLYEMLTGWPPFFDKDVQKMCEKILKEPLTFPARFGLSADAKSLVRGLLERDPVKRLDEATLRRHPFFATIDWTALEAKKVKPPFKPRVHGATDLQNFDQEFTKISVGNLSDDAAAGDDSDDDNFGGFSFTHRLPPARPASLLRSQRGHSMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X472</accession>
    <name>A0A6G0X472_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_008710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000109">
        <property type="protein sequence ID" value="KAF0734633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X472"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003823"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23313:SF0">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23313">
        <property type="entry name" value="TSEC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="102"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="180"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="271"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0734633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="429" mass="47306" checksum="EE8365B2F9453CD8" modified="2020-08-12" version="1">MPTGSRTAREAVLVQQNQDLNSAGVKTNEVVQTTIQAIAKQQVLDFTIEIGSPPSFQDPQTKDRKLSVVHTDNNLLSPATRANGNRVVSKAAIHVSTLYDDHSNRQPLREGSLSTSPSRDSFQSPLGELKLQISRRNPSMASLADSGGSRRDMLTPQMSKSNLSRSGSTVEIQKDLGSAVHVLEAQVAAVLANNKALEKETAKMTDRIEDIRAESLSLHRKLEQIQVQLDKQKTMQSTLETNYKGSEAELASVHSSLDEARRHEKQAAQSAKAVQIRLDRAVAELEKVKAELKKVKDGKGGSAVPRVEFERVVRENSVLDKQKVIKLSMGWQPQSLFPRRSSSRWLKSRASSLISSSGKRYTSRYSRTLLQGCQEYCLLGGRIQQNPGLGLVGIQSASSWLCQHHRSGDFPGEMALLRPRANAPASRWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X5B5</accession>
    <name>A0A6G0X5B5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tubulin--tyrosine ligase-like protein 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_008469</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000102">
        <property type="protein sequence ID" value="KAF0734997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X5B5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000078"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070740">
        <property type="term" value="F:tubulin-glutamic acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0734997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="33820" checksum="DD1EF7D2C3545308" modified="2020-08-12" version="1">MKKTECGKKWREIPWNDVLKQKCSADKYFMRSGLIRKDLLPVYSSEFMPPTHVVSSVEEFDAVLDKIKEDIIAVRADDLWVLKLSDSSNAYGIHFFHLKETTSVRSLLLDGQTRVLQKYVQPMLIDGKKFHIRALVLAVGHLDVYVYENVRVLLASAPFSTESLNPFIHITNQSVNKNGNPSYNNENQNVPLSDAFSNDVGTSILHQIHDICRHAFRCLATNRRHFFSLPNCYEIFGFDFLVDINGRVLLLEANPDPSLAMYNGEAILPSSPLDIGVPSTFAQVFSLQKELAFARLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X5L8</accession>
    <name>A0A6G0X5L8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_008157</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000100">
        <property type="protein sequence ID" value="KAF0735240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X5L8"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0735240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="73" mass="8301" checksum="E82C307786EF20D0" modified="2020-08-12" version="1">MCDTAHITHKGQFVIGCFSAVFCIPADVILEFHKARKDTCDEALKESIAMKTWTYIMAKTSYRHPSCNFPSQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X657</accession>
    <name>A0A6G0X657_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_008217</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000100">
        <property type="protein sequence ID" value="KAF0735304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X657"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002475"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07834">
        <property type="entry name" value="STKc_MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000046">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="146"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="307"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0735304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="550" mass="62375" checksum="391A308357351FB8" modified="2020-08-12" version="1">MAKTSSKRRAVEDSTAPTPPGIKETTPNARIPFGLKKMKSSDQIQPASTTSTPSPMHMHMRANNQHDYCAPTPYGPSAYMPPTPISPDMQHPPLQRRKTSMDHHQVVPPPQPAARAPPPSQKDVAMLEQQTARLWNFETWECGAQYKFVRPMGQGSYGQVAEAYDTIRQKRVAIKRVINVFDRAQDCIRLFREIYILRHVRHSNLVTLLDVIPPQSYDSFRDLYLVFEFADTDLQKLFCLPQYLNIRHVQVFLHQLLQGLKHMHACSIIHRDLKPANVLLNETLSLKICDFGLARVCVEDNNVADAPASPDGANSSGNNSSNGENSTPNGSSTAPPKAFHRQMTKHVVSRYYRAPELILLQEYGRPVDMWSIGCILGELLNMQAENCQHYLNRKPIFPGRSCTTLSPTDTVTYKKEMDQLFVIFNVIGTPEEEDIAHMTKFAPLLRQVPKKAPIDLKELYPGAPPEALDLLDKLLKFNPAKRLTVEEALNHPFLAEVPNLHSQEITKAEPLHMPNEDDDEHFTREQHKRRIYEEVLKFHEAAVASLSKHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X6D1</accession>
    <name>A0A6G0X6D1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_008055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000096">
        <property type="protein sequence ID" value="KAF0735488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X6D1"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0735488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="132" mass="15320" checksum="3AA312986584F043" modified="2020-08-12" version="1">MWDHHSAIPPHRYIHQIWAHHVLKNGELDPYDPPNREDGVELHYVFPGQDVASSLANNNDLFERILFAGTKLGPSSDCSFVLRPPPSSLYEKFYCHWSVAQNKLRRNVLLKSPQLKQCVKRVQWCCFIHASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X6D8</accession>
    <name>A0A6G0X6D8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MalT-like TPR region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_008003</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000095">
        <property type="protein sequence ID" value="KAF0735523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X6D8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021200"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0735523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="702" mass="80972" checksum="3EF4B3A54407FB0B" modified="2020-08-12" version="1">MNNDTESEAIDKPIGLTLSFFKRFVEIHGGREAFQGLTTGDVCTKFLLPYTASTKLSLAEHVCHQPGGSFYAKPATWFVSHAWSYLYLDVVDALDDFFQEQGLDDSVALWFCTFCNNQHEIEGHIHSFQHWFQIFRSALREIGNVVMVMSPWNDPTTLKRTWCVFEVYASIVENARFEIAMGRTQRAGFLQDMQSQDHVAFLQMLGTIQSEKSQTTMPMDRVNIFHHIHGEVGFAKLDRMVFDAIEKWMLRTVDQQIDQATSLGSKAAWLFSKGQIAEGEAQYDIAAALFQESYEKYRDEKGIMFPGTWKAFAQLAKQKMHLGGSHDDVEAMYLEALDHQMELLSRDHEDTLDTMTNLGDCYINHGKYDMALKLLLECFDHQLNLFGEDHQVTLGTMSQIGNALRHKNKPQDALQWMRRCYEIACRVFGDDHPQASVFQHNLGVLYNRIGDFGSAEMHITASCTAFERMLRLDHSGAVAFRLSLGDTYRHQGKYAEAKKTLLSCLQNENLYSRLKESCYQYLGYLFLAMGEFNHASEYLNRGLEYVTTQGNTAEKQANYLLPLFILKTKTAKFDHLDEIDSFEKAMLEINWIQDVWKNWTCHGCYQEIFGIVYSCVKCPALSLRYCRSCVDLKKQEAFCNHGRKFLEGEKPPLRYLQEQRLKIFLKNSQWAEYQQHFLAYQVYCDENHVSFDERLAQHTVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X6M6</accession>
    <name>A0A6G0X6M6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_008015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000095">
        <property type="protein sequence ID" value="KAF0735535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X6M6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019266"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020504"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF66">
        <property type="entry name" value="OS04G0158400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="548"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="618"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="855"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="202"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="337"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="103"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="118"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="165"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="548"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="855"/>
            <end position="866"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0735535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="884" mass="101721" checksum="A645457AC8B582AD" modified="2020-08-12" version="1">MPLKTKPSEPTPANVEVTPLRRSARLSDSEPTQQPVEDPERILREHRAAQRAEASRIRPDPVDVEINVHAERKRASESTPNVSPDYPSGFIRAPLKYLRTVSEDDSGDALMSDEETKEDIRDDIAFETRDDMRNDSAIETKEEEAASDVSQEVIDLTNDSDEDEIGTKNPRDDERKSSSESADEHRSREDFSVEKMREQIRAEVMVEKINQFEEAIEMARRARYEDELRSSDEIQRLRVEIEKLKDSMSAGSSENAQLKDLVSRKDDEVKRLEAENRTLRVETDKLVFASQKPCSRCSALEEALNRSILDSENLRSTVDSLQSGRSDQVCEECLKKLAEIEQLRRDTTDMMEQAKSSLKQREETHQGEVDQLENEIEFYRNQFEKLAESSDERENKFLAELFDLRRLSATECSICPTLRDEIQMLGQKVTKLGLEKSQEAQSSEMAKQRVSTLEMQARTRTVEMEKLQDAITLLQSQLASSKTSMESYEEKVKNFGEYEAFVQRELSSRQANYDQLMRLYSSESVNHRETKAKLHELHQELFRLRGQVPSTNVPPSETMSEKSSMWPSHPSYEMPEKKISPAPVEHIPKGNPFVEMMNGHESQNYDFAHLSHISARPTMTETRKAPTSFPVPESRDDQRRPSGRNPPSGGGSDGGDDGGNDPFGNDGRGFRPDSSSQFSASRRKMDPMKLAPELTRTDNLSLKYFLMEFERLREDFMLSDSDVIRLFSYRIRKSGVAEIENWWARRSRSQHDTNWDVVRNAFWQEFIYETSKKQVDELRHGTARKDGESIRMFASRLMLIGESNEMSDYLVVKIFKEQINDVTAYNFLKLARPEPRTVQACINLLDAYEIDTRSTDYRGSKEEGTSRTKRISNLPPHRNPRRMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X7P6</accession>
    <name>A0A6G0X7P6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_007568</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="VJMJ01000090">
        <property type="protein sequence ID" value="KAF0735974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X7P6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020588"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.30">
        <property type="entry name" value="Hypothetical protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007374">
        <property type="entry name" value="ASCH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848:SF4">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04266">
        <property type="entry name" value="ASCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01022">
        <property type="entry name" value="ASCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="5">
        <location>
            <begin position="28"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="6">
        <location>
            <begin position="96"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0735974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="314" mass="35533" checksum="C2109C529976BC6B" modified="2020-08-12" version="1">METTMADEYDNYNEEEEVEEVEEMVDDIPMFITNRIYLGSIDAARNPPGLASKDIRMVISVLSPYDKLNLPDEVARRHVRVDLEDDYEEHLFSKLPYLLHCIERFLQEEPEGNILVHCIAGVSRSASIVAAYLMVKENLDPQAALNQIRLSRPWVDPNSHFLDHLTLFHQIHSHVEVESPILAAALNVELPSLPKLHFHSQFVHPIGFSQTKTLTIRLESGKEDDPQSNLSSIYRFSTVVAVTEATEHFSFLHVTAVEHCTVDQLTLEHAQGEGLSSVADLMGVLDFFYPNLPGDAKVIVIHFRLVANIVKEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X8C9</accession>
    <name>A0A6G0X8C9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_007322</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X8C9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017835"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017836"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="371"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0736301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="455" mass="51543" checksum="3E1B78EF1376910B" modified="2020-08-12" version="1">MQLNIDGAFRRRVMGKPQALPRACSWKNAIKEDPHEVIDLVSDDEEEEKESHFDNNVHEDVVADRRNAEYSSVTTAMESLKRRRATASMVLHVKNLPVGMTPRNLWEILTEFSHEGVEHVSIPKQTDGLRQGYVFVKSRVAAEDVLAGMERIQGRHGDMRVEIMQRENLFSPLSSALVLMDLEAKPRLYFDHYMQILGTIFMDFDKFLAIDVVRNRSRHPSMGIAEDLSFSMPRRLYFNSSSTLLEYDPWRDLDDYQATSTLELVGLPFEVTKDDVVAALNWGRGCITSIWMPEKIVDGTTLNCGNVYVTYKNARIASQVKACYTSQGGVKVCGVQVCILFAASPTIPVLEEDIWTLDLPSTQDYRRDIVMSLKVTGVPCGISKTELKRMFSLRRGDIRSVDLVLPDATKTTMSSLCAIINYFSRDDALDSFRAADMFPIVLHGQRLHVEMADEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X8D2</accession>
    <name>A0A6G0X8D2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_007336</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C69 family. Secernin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X8D2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020389"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070004">
        <property type="term" value="F:cysteine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005322">
        <property type="entry name" value="Peptidase_C69"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12994:SF17">
        <property type="entry name" value="LD30995P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12994">
        <property type="entry name" value="SECERNIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03577">
        <property type="entry name" value="Peptidase_C69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026049681" description="Peptidase" evidence="3">
        <location>
            <begin position="16"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="576"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0736316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="610" mass="67414" checksum="EED0F0F306DD1BDB" modified="2020-08-12" version="1">MRTHWALLLIAAVVARQPQPDRCTAILVGPKASLTGSPMTTQTNDCADCDFRLVKVPAMQHPPNSQRSIILANQPYPRYVGEERGPVYNRSNLDKGLYNWTNTEAIGSIPQVEQTYGYIEGVYGIMNEHQLGFGESTCGARLWTKPISEGGKALLDITELSRIALERTKTAREAILLMGKLAEQYGYYGASWDDPAEAIEEAGEALTVTDPKEAWMFHILPDDTGASAVWVSQRLPDNHVTAVANQFVIRTVNLTDTDNFLGSTNMHDVAKRNGFWDGRSDFDFTHAFAPRYDNAYGMTRRVWRVFNLVNPGLILNPDTDNLATDYPFSVEATQPLAPQDLMRIQRDHYEGTAFDLTQGLAAGPYGDPNRYNVGSAAAHSSGFFERSISIYKATYSYVTVASPTNENHGLIWFGPYAPSETTYVPIYTKINTAPTRTGHGSLRQFDMDTAFWLYALVGNYAARYYKFAQPLVTSTQNTLETKAILDQTAIQTKAQSISDSQGADALALYLTNVCESFATDAHNGFKALFASLVTQFHDGYIMSNFTSAEMGVQAMGYPEWWLNAVGFYKKSDTTSIGAAIGYVVLVLVATALGFFIGQRYAHPKGYAALH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X8Y5</accession>
    <name>A0A6G0X8Y5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">RNA helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_007545</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X8Y5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007747"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17947">
        <property type="entry name" value="DEADc_DDX27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF14">
        <property type="entry name" value="DEAD-BOX ATP-DEPENDENT RNA HELICASE 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="10">
        <location>
            <begin position="200"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="231"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="416"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="83"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="734"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="578"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="200"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="735"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="751"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="786"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0736535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="805" mass="91735" checksum="2BC9D6B081312598" modified="2020-08-12" version="1">MTIESDDEVTRLDESSDEETPEEEAVISKQQKKKLLKKEEKKKKKAAVNDISDAFEFDDDSSFKGPTGCSWDFTKAIAHIDSMERRAFGESNRTTVQTKIETKRKERQEARKEQKRIEKADSKVAEAQNEEDSEKDEEEDDEDDEDDEESADVVEEKKLQQALQERKQTQAIEVVDEVERKKAEAFFETEFQAPHLDEVKSFSDLKLSRPLLRAVSSLGFDTPTPIQQRAIPVALTGKDICASAQTGSGKTAAFLLPILERLQFRSRRVAATRVLVICPVRELATQCQSMLEQLGKFCDITCALAVGGLPLREQEAELRACPDVVICTPGRMIDHLRNSKSIHLDDLEILVLDEADRLLELGFQEEVQELVKFCPIARQTMLFSATMTSKVDELIKLSMKRPVRISTDPLFDMARHLVQEFVRIRPQREDDREAILLALCTRTFKTNTIVFMETKKHAHRMMIVFGLAGIKAAEMHGDLSQKERLEALQSFRDGTVDILLCTDIAARGIDIEGVHAVINYQMPKDVTTYVHRVGRTARAGRNGRAVTLTSENRRLIMKEVARHCHGFVKSRSVPDAVIAQWKKRIESMEDDVKSVMKEETIEKRIREAEKDATRATNLVRHKDEIASRPARTWFMTAKEKKEVAERAEEHRKANLFVQDEDDKPDRKVKLNHKKRKIAELREREEKALEGADDSGNKKVFTAQHVAGAAKSAKRKAIEAKRVLASTSIAEIHEMKRQKKEKAMQRKAAKGGFDKDLSEKRDAAPKKKKAEANGEFVFKEKITSLRKQGKRSVHSFKSKARYNRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X903</accession>
    <name>A0A6G0X903_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_007546</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the proteasome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X903"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006322"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03758">
        <property type="entry name" value="proteasome_beta_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035206">
        <property type="entry name" value="Proteasome_beta2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF2">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0736536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="199" mass="22193" checksum="7269BEC846758644" modified="2020-08-12" version="1">MESLFGIVGKDFVIVGADSKVARSILVYKDDEDKMQALDSHKIIAGSGPQSDRVEFCEYIQKNMKLYQLTNGVTLNGHAAANFVRGELAQRLRKAPVQLNVLLGAVDVEGGNDKKVLPSLYWVDYLGALTKVSYGAQGYGAHFCLSVFDREWKENLTVAEAKSILQHCNNELNERFLVRSGKWLYKLIDADGIHDLNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X938</accession>
    <name>A0A6G0X938_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Post-GPI attachment to proteins factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_007057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000088">
        <property type="protein sequence ID" value="KAF0736607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X938"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018280"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0736607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="142" mass="16182" checksum="883474A48B7E55FA" modified="2020-08-12" version="1">MTDNKTGAALVLPPQYSSRLFRSSWLTAASVYSAAHHDNWICFGMTLLVLLTSLNYWRHPVHGWRRNLDMSTVFLGFAYHIYSSLFCASSYHQLFYYAFVVKTAYCYTQARAAPNKDVSSRWHMTMHLVGNVGNLILYAGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XA49</accession>
    <name>A0A6G0XA49_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_006795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000085">
        <property type="protein sequence ID" value="KAF0736983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XA49"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008428"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0736983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="109" mass="12399" checksum="8DBDEF825B6D2DE9" modified="2020-08-12" version="1">MERLLIDALDTIPLEDALELNVDSIDMTDLGIFDLSVNSEAAKVLSSPKQAQTAVSLSYDEPRSVSNQEMLTTEIETLPRKQINASRKRQREEMEYLRAKKSWKNISKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XAC6</accession>
    <name>A0A6G0XAC6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Trichohyalin-plectin-homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_006817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000085">
        <property type="protein sequence ID" value="KAF0737006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XAC6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005161"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0737006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="467" mass="55666" checksum="7AF9281A34826DCF" modified="2020-08-12" version="1">MLNLTAQQKALVANARARKEGKALTVKLKEQAEADRRQHLMEKRAKALQNQKHVDNKLAVHYIKKELAKYAFGDDYKKKRHRGGRASTVPLIPTRPPEAPKSERIEQALDDEIRRPPRYRAPNAWAKLYELEEQEVKLEKEQKLRASMDNKQQARLYLKRQEEEKQRQRQLEMESEMKYFERQQRDLDRHKEEIKQKQIAKEEKQRQMNAEFNRMVEETREKRERQRRLKMQAELQEVERAKAALDDERHRLEEEKRIKAKQVEQVKIENRKIQDSKRQAKLAEYEYDKKLSKEYQERLAAQERARQEELQKTYERQEKRVNMALLNVVSPEEKARQDEARAAVIQSAQRAKEEAMLEERQRKQREQSFLQGAELRKQQEERRRRQIQEREHAAQLDALVAQDALAAEIAARAKQAKKDAIDREYRAKLAQQMLAEQNLKARDDKWAMSQLEMKLNATTLRKAGVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XCP5</accession>
    <name>A0A6G0XCP5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Alpha-mannosidase</fullName>
            <ecNumber evidence="7">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_005901</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="7"/>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0737904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XCP5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003692"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10810">
        <property type="entry name" value="GH38N_AMII_LAM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.50:FF:000002">
        <property type="entry name" value="Alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.110.10:FF:000001">
        <property type="entry name" value="Alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="entry name" value="Glycoside hydrolase 38, N terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="entry name" value="Glycoside hydrolase family 38, central domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050843">
        <property type="entry name" value="Glycosyl_Hydrlase_38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11607">
        <property type="entry name" value="ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11607:SF3">
        <property type="entry name" value="LYSOSOMAL ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="Families 57/38 glycoside transferase middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026377590" description="Alpha-mannosidase" evidence="7">
        <location>
            <begin position="18"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 38 central" evidence="8">
        <location>
            <begin position="356"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0737904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="977" mass="109922" checksum="0DD6131E041B8EE3" modified="2020-08-12" version="1">MHVWLSVAALVASKALAEEMIPLPSCGHWTPQYPVGQHYNTKASISTEKLNVHLIPHTHDDPGWLITVDQYFTQEVDYILDTIVTELAKNPNRRFMYVEQSFFQRWWREQSHGMKHLVKSLVKNGQLDLTANGGWVMHDEATPHYSSMLDQTTFGHKFLLEEFGVRPRIGWQIDPFGHSSTQGSLLSAGIGFDALYFARIDHQDFDKRRDEKNLEFIWKPSPSRNESVFTGMMQSGYGAPDGFFFEDDDPIKDDPWLHDNNVCARVKKFIDVTLERASHQRGNHVFWPMGTDFKYQNALKWFKNLDKLIHYGNQEGRVNFLYSTLGNYTDLKLQDKSIQWAVKTDDFFPYADQVNGFWSGYFTSRPALKRYVRVANNLLQSLRQLEVWAHAPGTQINHLAATVGLSLHHDGITGTEKQAVADDYAQRLGEGVAVGEKRLRELVGGQFDVCLLANISICEQSTTNKSFTFIVYNPLTEANTYSINLPIVSAGANVVQADGTKVPSAVVPYNRVYNHDIAHAVANQLVVLAVVPPLSWLAYHVTPTSENSQSTSWPVVRDAIVTAENNFVRVEIDTNTGSLVTLQNKATNTTIKVKSSLLFYQAYAKDGDSTSSGAYLFHPNTSKVHPLGAVSGHNCVKINDVQSCSFQFGAWGSLTYKLHSWDQNVEVEWTVGPIPIEDAQGKEVIVRFDTSLATEKKWYTDSNGLEFVERIRDYRETWNLTLHNEEEKVAANYVPITIATYLRDTKTQFNVITDRAQGVASLEDGSIEIMVHRRLLADDSKGVGEHLNETETIDLPNNKKVTQGLTVRGTLAITVGPHDQAIYFLRKEMERRQFEPLVAVGPYNKSLDVPLHASFEPRLPVNVGLTSLQVKCSHCVRLRLTHLFAVNEHPELSKDATVDFKLLLGNHWPKLRIKELGLTGNIELGQIEGTTAVLKPMHVHLFEVCDGSHESSPVFDASVSSLVELTSQHDGDKEPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XCW7</accession>
    <name>A0A6G0XCW7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_006044</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0738053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XCW7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012894"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967:SF92">
        <property type="entry name" value="LD17053P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="241"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="100"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0738053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="530" mass="58645" checksum="ED1745914D65FE00" modified="2020-08-12" version="1">MLVLYDILGEVGNSEHHPNAFRIPDDVHPIRLKHVQAACPFEYCQFSFQHENGVYCSYTNPNSVVPLVNRTRIQAKIIVSEPFSEQGVSREDVVAVDMSVPSAQTSSRTNSSSSSHRRTGSQKDYDAPPWEAAFGDSRDGSGGSNSSRGESPSGIGGISTADIKEKFKKQTEMAKDFAKNLHVDDMKRNAVEFAKNMNLDETARKAKKWGGSLLSSISSTISSASSAMSKGEVLAVGTTQVNVLRLLADGKYNQTFLVKTIGANETCALKRIAITSAETEKDASIERQVLQTVRHPNVMRMLQYGENRSSSKQECLFLLPFYDHGTLWDAILRSANDTEVPWAFSEIRLLHIFEGICEGLQALHGAGFAHRDLKPHNILLDHSDHPILMDLGSCVPLVTEIADRRLLLEVQDDANRKSSPPYRAPELFEPQIGQTVNGQSDVWSLGCILYCMAFGSSPFESPREGFLRGACMNGKVSFPPLEDDEVHFRGEAYSVDLCEFIKDMLHPDPADRPSLADVIEYTKELLITQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XCY2</accession>
    <name>A0A6G0XCY2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_005905</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0737908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XCY2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003696"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004502">
        <property type="term" value="F:kynurenine 3-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070189">
        <property type="term" value="P:kynurenine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46028">
        <property type="entry name" value="KYNURENINE 3-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46028:SF2">
        <property type="entry name" value="KYNURENINE 3-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="8">
        <location>
            <begin position="2"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0737908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="470" mass="51850" checksum="B2FA6C2258005229" modified="2020-08-12" version="1">MTKFIVVGGGPVGCLAALQLAKHGHHVTIYEGRHEIPNDPEQSYPIGVNPRGLHAIESVAPDVAAQIRKEGRLVDAWDIYAGPRRVAHQPSGVVYGTSRGAVNLHLWRACEQLPDKITLVMCHRLRSMDFNAKTLTFDVMDPQNPNVKQSVVVNAEDARIIAADGVHSTVRTCVRDADSGFLVDVLPWTNEYRVLFGIPGKLTDEIDPAVHYIFTGGYTAVIDNGGQLQWTLTTTVRDADSDSSLSQLVHESEATEDNIAKLKKWIDSIAPAFAALVPEQEWSKYFSRRTYRGAVVHCNRFHFGQWVVLLGDAAHSVLPPTGEGINSGMEDTFVLSECLASGGEADLFERYTAARKPDIQALFDYASHLNTSPTFAGERIARLIFLIVENSSKTSIGENLFGPSGAKRLSYRKIVDTWRLRRAIWLNLARLITYPLAGIAALISLPFSLFKAKTPKKLEKTPQKQLQGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XE80</accession>
    <name>A0A6G0XE80_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_005811</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000076">
        <property type="protein sequence ID" value="KAF0738375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XE80"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009283"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209:SF867">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209">
        <property type="entry name" value="OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="161"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0738375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="309" mass="34734" checksum="C42BAD140EB702CB" modified="2020-08-12" version="1">MEIPVVDCSSADASSQMRQACIDVGFFYLANHGIPDGLITSVYDEMRHFFSQTDEEKRKVLANENMRGYTAMNEEILDPAVQTRGDTKEGYYICREAQDDELHLPLHGKNVFPDPVAYPSFRPVMQEYFNRMSTLGYHVAQIFASAAGAPGAFAEPGMFDRPMAALRLLHYSDCKSDIDSGIFGAGAHTDYGLLTLLSTDENPGLEIYHNQEWIAVPVRPNCFIVNIGDMGERWTNGLFKSTRHRVVNRLGVERYSIPFFYEPNFTCLVTCLPSCVSASNPAKYQPITSGNHLLEKYRETHESFQEPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XEE7</accession>
    <name>A0A6G0XEE7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_005649</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000073">
        <property type="protein sequence ID" value="KAF0738537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XEE7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016380"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126:SF14">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="573"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0738537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="614" mass="66141" checksum="AB35010E629E2C35" modified="2020-08-12" version="1">MEATPPAASSGAMASKATPSSAPSSPTAHLQLKPADENTASSASTASMLSERSEAGTASVSVVVLDPPPVKEVKEIKNEGKEVKEIPRLPTMNFESFYQACQEGNLASVRDQLDSGHDLFDVNAFTKTQDTPLCVACVEGRADVVAVLLANPAINVNLGNYSHPPLALAAGLGRLDIVKMLLNHPSILINVNTSKRTPLTAASENGHLEVVQLLCEQPGIEINLQDLHGHNALFAASLHGRTDVVRYLLTRPNIDVNLPCVRPNRFGMPLTEAPQAGDLPLTVTASYHHVDIVRLLLAVPDIDVNKPDQDGLTALIHACDEGLDDVVQLLFDSPKLKIDKDILREMIARSVDKGRASVLRLLLTRHPLPNTTDLTMGIEACQKGHLSVVELFLELGLFQNDPADTKRLAVYEALANKHVEIARLLLKRDDFGQPSLLHVAASSGFEDIVKMLLPNKEDVGGLDTNDQTAWQLAAQSGHWNIVSSLLQADLPFKIQDDAIVPRSDHGFSWPEFADPTSALVGNPRRSELATAIVLQFPEQKQVAVAKALLAATDATSRTVESFTDDQTRNLLSSWTPSPGLAESPSRKAIRTPGAVPVIAVPVEEAPKAEQKPNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XEM2</accession>
    <name>A0A6G0XEM2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WRKY19-like zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_005632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000073">
        <property type="protein sequence ID" value="KAF0738520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XEM2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007890"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056866">
        <property type="entry name" value="Znf_WRKY19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827:SF1">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24906">
        <property type="entry name" value="Zf_WRKY19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WRKY19-like zinc finger" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0738520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="195" mass="21675" checksum="FA9D944367C462FD" modified="2020-08-12" version="1">MKCYFNGCNNAAAAGSFKCLFHIHRSRCLIEGCRSQVYARNLCVRHGGKRQCAFEGCKLNSRVGLYCTKHSPSHILRLCSLEGCDNQAHLRGLCFRHGGGRVCKVEGCETFARNRGLCARHTPKAEKKTMTKTTIKPSCPPLDLDTTTTAAPKLDETMLDWLLSGFFAEMGEIDLIKCEPSPPMVCVQEVSTWQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XFT8</accession>
    <name>A0A6G0XFT8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_005287</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NFYC/HAP5 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000067">
        <property type="protein sequence ID" value="KAF0739108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XFT8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010975"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22908">
        <property type="entry name" value="HFD_NFYC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000006">
        <property type="entry name" value="Nuclear transcription factor Y subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33667:SF7">
        <property type="entry name" value="RIKEN CDNA 1810020O05 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33667">
        <property type="entry name" value="SI:DKEY-57N24.6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="8">
        <location>
            <begin position="1168"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="713"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1092"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="718"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1092"/>
            <end position="1110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0739108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1244" mass="139009" checksum="E274D7BA56E59FDE" modified="2020-08-12" version="1">MSESHAALPGHPEAKKVKWTLTIEVSLNESEFVNPVFRYRFIDGSKKVTPPVGAAGAWVAITADGALATPVPTAPPAASGKPPSSARQQQTQTAAAVDAHVGAMTEGTHKYFRHEHVVGDVEVTEAFATKLHENPILTLFLGDQSTVGATAVGDHATIAGRNYITFVELDVSPLLGGDLVVEQQWGSEAPAKDRHLPLGVPIVPCHGIRSLVVRVKVEQPILSPSLVKELNPITFSLRKVSNLPGITVQAKPLLQFITPTPHVALHKCCMPTYASFRLPLLPNRVVRTGGILQDTMVVWNYRTTFLSSHFDRVKLRELLSSGAVEVEVHDRDVKLYQKYIDLVKKWESTIGKPIEGAHDPHTNGHAHGNAVAKMDVFHVDEIAKQDIQALFVGAGDGNPHGLASFRLYELITMSSAQHLQSPSGSNKPFAQLAFTADVVQRKRRKPPKEGSDEEINLSQLEKLVRQPGAYLNCLTALSIDVTLQHALKDDKTHGAFSRMVVVMPYNDVATLQCISKAIETVNSQTLPGAPLRSYQLTAAQKQACDLGELNLITGFQVIDANFRMIFLEGLATSGMTTVTNLVPRTTANSTTTGFRMFSNPDIRFSQRLYTAFDVDLKRIKLRDPLPDITKRPELYMRSKVSENCFQALNRLSDVRKANRLVELLDLDLFPTVAMLLEVESKYGESITLQDIHGSEHHAAKQQILRQLQAPLTDDQTDKSQNTQMTSPTKTNERRLRHTMPETDSTNTQFELAKKNWKPKDYLDIRRQERQAADETYAQSKAMLPPIPDGPVYIYSGQKLRTKELEKDTMRERLAKDKDATFTYSTEFNSLTMSMVDETKLALLAEQASKAQWTTPGGFVYPAPRQPSEFYKHKDAPSAARCEDLHAPWIENLYHPQPLSRGDGGNEDRHKVSFDSLPSKDMVFGGTNADGSVNPEYFKSVHLVGDGLAKEMEEAKAKEHKEWLEKIVVDHDNLRFIAHGDIMGQGRARPSALDKPQDILAGTVRSKPLRIVRNAKLPSGKQVPLHAMPVSIMNQDEYKGGAKQMIERDRDPSQFVARTNQGDPKDFFFPSITQILVPNVNKHTTLLKPRKPLAESEKTGLRWKNPSHEPRQQTTMEEQGQVVQLTQEEHAAHMAQMEQQLKVFWAGQLAEMEKLEVGSEQDFKNHNDLPLARIKRIMKSDEDVRMISAEAPVLFAKACEMFILELTLRSWGYSEKNKRRTLQKEDIQTAIRNTDIFDFLVDVIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XFX8</accession>
    <name>A0A6G0XFX8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_005193</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000067">
        <property type="protein sequence ID" value="KAF0739005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XFX8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000504"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052394">
        <property type="entry name" value="LRR-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="683"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="719"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0739005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1106" mass="123935" checksum="34C8D34528463BDC" modified="2020-08-12" version="1">MPCRPKPQLSCNTFESDGVQIDDASGAVSYAMHPSMEAKDANQAGDSSKACPVYQPPAPRLHTAPWTRRLEKLQPLPRPATSSDAPTKLLGRMSWDPQVLEVDRTSCRPDVRTESQEKTMKRTSNLDYERILGNVKTNSAVQAHLKRQESHYLTPIERPLAFTPMEYNRCSSSFLEPTADAEIRDGGELKTLTQANQAKYFGENAKHGFYEQYRAISKKPHLFRPKSRRAIDEDEDTTPRTRVAVQSFSKHQLALPLVIRKQTTNVFDFSYQSLGDDYMLQFAAGLDALPFVQEINVRDNRLTDDGLNALLAAISKQVQLRKLDISENNMGAATAKSLRLFLESKTCSLTHLVLEKSDIDDFECAAFMTAFEKNSSVVELRLSRNRIGEAEELNVVQPEITTGGEAIASMLYVNTTMATLDISWNLLRLESSVTLAKSLEFNKKLVELNVAYNACGDAGAMMFGHVLTLNSTLRSLDLSYNNVGSRGALVIASAARVSKSLRHLGMNGNNIGLEGGRALMFAMCSNPADLGCNIEIVGCNLASTSRGKTAAEKLFDPTNPAGVYSLDLSDPFDQMIAKELLRLATFKKGCRFEKLKYHSRHERVKSKGGAIQLVHPVVATMANNPLDAFYAQSVSKKRTKGFHVDVFALLAVFRTMHMNPTVETLEKVLEKMKATWTEDSMDFTDEFFSAVFELTDTDGSGGIDASELCEIMQTLGLHMTDEESKRAIAQYDFDNSGTIEDFEFIELMKAHMRHHAIRKSTVGLNPDRFALRDAATSQVWQVPSEGRLEVEFVYEREAVLDADLERNRISDAGIAQLIRNIHMQATSPTERLEMLCFAIADSEMLFSAYQALDLLEQCGGLAKTTRVQAVGHILLQMITPKDAQRLAAITLDLRDRAKLKADLGSAYAVVMGNPTAHFALDLTNKTDRWVACKLAETAHAEKKASKMSTRGDTSQHMNWENFRNESLDGEKVVLTTSFFNSLPPSGRLEFDYVSTNRPPRGTKALSQRRYEQLVKELAKDCVIIDVPDASAPEDPSTRALRRWKRLQDYVRHSHFISMLRYARSHIFVIKNCREEVRLKLAQIETVVCDRYLTTEQVTLVERRTWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XGV0</accession>
    <name>A0A6G0XGV0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_004714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000063">
        <property type="protein sequence ID" value="KAF0739532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XGV0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010556"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="110"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0739532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="208" mass="23485" checksum="8C18D1F5759320C3" modified="2020-08-12" version="1">MLASDVKQVVEDSGDISQTQVQYFGDFVLTALNHSSRRGLEAMTLCLLRHEKEVVPNEAITPGIPNNQSQSDSICHSAKLLQYSCIYGHLDLIRELVRRSGSAILNFHSDDGPAIIYAIAFGHIDAVRVLMQAGAEISSLNSIHVPSMKRWHEFRQPATPQPSWPFYQPQKAKRRRRSFRGPIEKYEVVERLPREMLAHITSSSQFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XH63</accession>
    <name>A0A6G0XH63_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_004827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000063">
        <property type="protein sequence ID" value="KAF0739655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XH63"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001214"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026165619" description="Apple domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0739655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="19109" checksum="191C7CB7EE3A5103" modified="2020-08-12" version="1">MRFTSILLAIAPLASATTSWVSVNGYWFSPAGGRTSTVNATSVVQCFDIAAKASLSFANYNSYAKSCYAFEESNSYLQDTSYVTGIAKYDSSDFSCSGNVDFKSTSFRLVSQDRLGFKECMAKCAAAAAAQNTKNACDGITWEGVGSNNLGTCNLKYFGDNSFNTKTAKGLIACKYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XHG8</accession>
    <name>A0A6G0XHG8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_004875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000063">
        <property type="protein sequence ID" value="KAF0739707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XHG8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018171"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055336">
        <property type="entry name" value="At4g00755-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39741">
        <property type="entry name" value="F-BOX DOMAIN CONTAINING PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39741:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0739707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="32089" checksum="E1637D107FAFCE57" modified="2020-08-12" version="1">MDRLPRELWMSVAAFADHESLHAMELTCRLFFWSEDKAQARVLWQQSVVRSALLPTARDYRYITRWKHFACACEIMDKEPHVTLFEDVLDVSSVHRHDEECASNTLNYSQCYRVAAMLENEEPNHILNEYNIQRLICDCSGGDCYWSSAPTLSREDDDFIVYSLLGTCIIESIQVIPYQAFWQTGEPAYAPCQVSMALHEDKDTEPVYVSPAYDVENTMELQTFQLPHKVLARGNVVVRINLIGKQQYEYVSLGPGQPLRYYCCMSYITVRGVFYTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XHV4</accession>
    <name>A0A6G0XHV4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_004565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000057">
        <property type="protein sequence ID" value="KAF0739907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XHV4"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0739907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="70" mass="7641" checksum="00D8CC09A7273E8A" modified="2020-08-12" version="1">MGQECHPCSSNLVKLTISPRSFLSSTKFVGFKECLFRSSQVEVCSGTPVCSVTLPVILHGLCANNSHYTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XI68</accession>
    <name>A0A6G0XI68_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_004672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000062">
        <property type="protein sequence ID" value="KAF0739786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XI68"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009669"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="576"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0739786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="724" mass="81349" checksum="05AD69066EBA3B5F" modified="2020-08-12" version="1">MKPPWLTYCSKLGYLYAIVSPGFSIAYVFILAEYTTNDHFWPNFNSTGGYTFLADVVNTKLRLGELGEFDIFSQAILKDYSLPKTYIDIRLSSTRRALTHSVSFEMAVAAYRANTMFENANTMAPYCWVDFGHQYEMAHTAKRQLRCAKKLFDNAAAHMESLLRNTRLSDLMQSVYGIQINQTILTAVLTLPGGTTWVANLMKLMDDDWGSIPDEVAYWRSQGTTYFAIQYQNRFQTGNLNRIDVVNALGITRSMTISTVPYISRSLSLWSTRYVNTGWCGWWNDMSKCVSIGTNMLRNTSQSIEALGRNWDTIYTGATTTVGGDIVRAYVGPFMTWDTKVLSPPPSLLKMLANFHTQFYDLLRSDISFSSAYQNIFESDIDVVPSNWGGQDMLYYGGNPMCSLITQPKTYVQMPFSFDDACQRQDRLAILFSRTATLFSMWISQPQTSSTIATSCNLSLLNAISCLMSTMPLVSKLTTPDGVSSVVQDLQSLNLLFVQLASRNSSKVLLTQPIIPNIGDPWSPFGWMTLYDWVDGTREAYAFEGDVGSLSLMSARSANLPVASNPLELPRTACVYFRYAALYLTLNVGVVTILLLAYSALGQYQSDGRNFFQINRVVGSVWAGRPLMFLRGTTAILVLSTSPATLTSVNQVTYFENVVRHWIIRLILSGESLWVSYAMNDVLLPITQQYSRMYTPLHSLLSFIAIFVLDTNVSTGRCVFWKCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XIB8</accession>
    <name>A0A6G0XIB8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RRM Nup35-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_004330</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nup35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000054">
        <property type="protein sequence ID" value="KAF0740089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XIB8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019532"/>
    <dbReference type="OrthoDB" id="3365060at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044615">
        <property type="term" value="C:nuclear pore nuclear basket"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12441">
        <property type="entry name" value="RRM_Nup53_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000095">
        <property type="entry name" value="Putative Nucleoporin NUP53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007846">
        <property type="entry name" value="RRM_NUP35_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21527">
        <property type="entry name" value="NUCLEOPORIN NUP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21527:SF6">
        <property type="entry name" value="NUCLEOPORIN NUP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05172">
        <property type="entry name" value="RRM_Nup35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51472">
        <property type="entry name" value="RRM_NUP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7 9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RRM Nup35-type" evidence="11">
        <location>
            <begin position="147"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="33"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0740089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="278" mass="30763" checksum="E420310FF91A37C7" modified="2020-08-12" version="1">MSTPTSDADVMPMFFLNPGGGPSSNDKKEEDSSTPAKSSYASLPRQNYQNPWEANGLDQQYQSLRKRNTGANGLGSNGDASSSSSTSESTSIFRDTTATSIPTNSLFASLSSKLDSRSTATTPASSESSAKSSSFLFPSLQTQEWGHDEVYWITVFGFPIQDMDAIFSYFQTLGDVVQYRYGRGNWLYIRYRTRLQAEKALQESGSTLSGRIMIGTKRCLAWEMDADAPVCNLTDTHAPPAPLLSRDLQVNPPEIDVMESPRRQDDMCSRFLRFLFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XIW1</accession>
    <name>A0A6G0XIW1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_004326</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000054">
        <property type="protein sequence ID" value="KAF0740084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XIW1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019528"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016231">
        <property type="term" value="F:beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030203">
        <property type="term" value="P:glycosaminoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000063">
        <property type="entry name" value="Beta-hexosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600:SF26">
        <property type="entry name" value="BETA-N-ACETYLHEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="9">
        <location>
            <begin position="2"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR625705-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0740084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="327" mass="37536" checksum="D64BB59FE27FDBCA" modified="2020-08-12" version="1">MAYSQANVKELVAYAKAHGVQVTPEIDAPAHVGAGWQWGLDFGVGELTLCWANSPTVYHQCWEAPCGQLNPMNEKVYDLLDKIWGEMTDLFESDVYHLGGDEVFTQCWKNSTVVSDHVSNKTGDDEYFEIWAKFQERVQNNLWKRAPKKKIQLWTSDLTTDKFFKYLPKDKVIIQTWGPAVNNEPRMITDAGYQTVVSFQDFHYLDCGFNGIDRKDNGWCAPYKTWQMIYEQPLDFNVTANNARLVLGSELVMWTEVSGEAALDTRVWPRASAFAERAWTNPSTRWDKAMPRLTIQAYRIIETGVAADLLQPHWCRQHPGECPLIVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XIW4</accession>
    <name>A0A6G0XIW4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_004233</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000053">
        <property type="protein sequence ID" value="KAF0740228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XIW4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016777"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18042">
        <property type="entry name" value="DEXXQc_SETX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000326">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF495">
        <property type="entry name" value="HELICASE SENATAXIN ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="6">
        <location>
            <begin position="606"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="6">
        <location>
            <begin position="719"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="7">
        <location>
            <begin position="813"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="109"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="369"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="284"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="303"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0740228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1033" mass="114119" checksum="3B294F8E389C3068" modified="2020-08-12" version="1">MPPTHARAVNSSSRAPPTHELPEALLDVENAMDRLKNHVRDGTLSQSVRRRINALHVMVQSLRVVVDEELKAKNAEPVLPPAPSRMERTEFNCVDTAMEEMKKRIRAERKRIVADTDATESESEQRKKSQSSISTPAQLENSSTSKSESGLKKKRKRIIHMSGSSDDEKVPPPKLKIQPLSTADEDTDTDVEQNPSNDTAALSTNTVTENVIKVEPTENQSLQEDIEMLGGGDETEDENPSHADAEDSFLDTSTQSLESQDHAVSNESTSQQLPVIPITADIPSASSSSVGDNSPPTKELSRISVQPTPEVSPSRSPVRQLLDAAPPSAVDKHLAANLGNVVDLSDSSSSSDDSSHDVRKKRVSVWNLATSTAPASSNSSNSSSEDEDSDGPETNALALSRTVTPLQKRALWPNLDRYYTMLLDPVPPPFLPKGYVFPMTYPTIMDYVKALKKAILQESLNLFDPRGKSPSIVGRNISVVSVSRFNDTLQSVVFRLPKSVTLQSHDILQLEASTSRNRFPGIAVSTQLTQDDFIVLVSTAYSIDVLASFTLINVGNLITSSREYQAVLSLPSWPRHLQDIITSATIPKAKSLGTLPTTLISKLQKKFNSQQFKAIQMAIHQPITLIQGPPGTGKTHTILGIIQSLLQQPSSRRARISVGAALGVDTQPKIRLLVTAPSNAAVNVILYRMQAIHPDINMIRLGQPSSPSLVWLENLLDQDKNRKKADFNAQEARERLLDAAQIVFCTLSGAGSWAMWNPKQSHFDAVIVDEAAQATEASSLIPLRFNAQRYIFVGDHKQLPATILSTQLTRMEYDQSLFQRLVCNPNNPAIMLREQYRMHPAIAAFPSSMFYYNELVNASNLESEMIYHSRGFPPYCFYDVTDGSQSRVETTYRNLPEVEFIATRLRALLEVPYDFRNKIGIISPYKGQIEAIKAALAAAKLTKAKIEVNTVDGFQGREKEIIIVSCVRTLKSGDNSFWGDVRRMNVSLTRAISSCWVVGNSALLKESPAWDQLVEDCKRRNAYERVVVKRPVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJL7</accession>
    <name>A0A6G0XJL7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Clathrin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_004063</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000051">
        <property type="protein sequence ID" value="KAF0740517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJL7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005993"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="87"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0740517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="144" mass="16498" checksum="45A2EE02579F53A4" modified="2020-08-12" version="1">MGDRPAARPIFTNEEEENNEVSWLEKDPNDDADEEEKCLESLPVETNNSSNSYPTNSTSSKRGFGMLDIWREMTQATTFIDKERAGIEKAKLQIESKRLRLDEEKSKWEAESRRIQALKEKALAKLELKKAGMTDEEIAAIFDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJM4</accession>
    <name>A0A6G0XJM4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_004159</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000052">
        <property type="protein sequence ID" value="KAF0740424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJM4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005198"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="93"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="126"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0740424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="268" mass="28688" checksum="D4CCF7872AD8B0C6" modified="2020-08-12" version="1">MLFHLRSAVRWQRRAFSTSSLDLIALIKSSQADIALETLSDGASCTPQTMDWATTDAYGSTALTLAARGGHIALCQAILPHVTPDVLNQANMFGSTALMCASASGHAAVCKVLLEAGADIQVRTRYGSTALSKAAEAGHDAIVTLLLVKGAEPTANVMGKTPWDLAMEKGHILTAAPSVQNEAQPVSARVTRIISSAHVECVLASDGSAVIVTKQENRLVPVNAEVRLVQDDQGSYRLQELVSSVTKQRCLHPRRAYEKKCVDCPERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XKA9</accession>
    <name>A0A6G0XKA9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_003889</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000045">
        <property type="protein sequence ID" value="KAF0740758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XKA9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012776"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051052">
        <property type="entry name" value="Diverse_substrate_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942">
        <property type="entry name" value="METHYLTRANSF_11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942:SF4">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="4">
        <location>
            <begin position="55"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0740758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="292" mass="32751" checksum="258B2B8E97AA8FD7" modified="2020-08-12" version="1">MYRRGIKSFSSIPLPQGFNMYEKARPDYPARALATLNSFLHLDDQSHTTGLIDVVEVGAGRGKLTKALKRVLPKQTRFVALEKDASLRNELQSLVPGVPVYQGCANETNLPDASVRNIVIGHAFHCMADANALGELHRVLVPNGRLSILLNTADFNSSPFMNEVEYVVKSFNAAYTPHEEARALQEIFHECPLLFSKMESREIRTVLTASVEGIVKYLMSTCVISDLSHRRQTDVRLSIARLIEMNPDVRLENGRRILDLPCVVEMHYVEKRQALETEGESTESNRRALQGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XL01</accession>
    <name>A0A6G0XL01_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_003667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000041">
        <property type="protein sequence ID" value="KAF0741098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XL01"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0741098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="169" mass="18667" checksum="4F217D016168B976" modified="2020-08-12" version="1">MHLTGFPSGRTRHQEHRTHSVFFPSASPIPCDSHGRIRTNMNRIGAMLRQRSTNCAPLSWQTRVAFIVTDVPLGNPQRFHRRALLEVDGGIECVSLTRAAHPVAAMSIPPRAPPQFVDLSEIGFSDVMIKLSSAVLSNSDEQTSSFSRTSALRAFTYDDLQSSRAPEPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XMD5</accession>
    <name>A0A6G0XMD5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_003226</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000036">
        <property type="protein sequence ID" value="KAF0741543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XMD5"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0741543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="251" mass="27182" checksum="12599525DF906523" modified="2020-08-12" version="1">MLALIGHSLGLGGCDGRLVIAYSPRNHMTSLATPQLVAERTFKTRRHHRSWQEVRLSSDDQERGPADIAVTGQHCTFSLEGLSWLRRSAACVDHGDVGTNVVPRARCRVAYTSSGRLGHRLLLVCCIRGSESSRSVLRFHDGLDNCSVGVCLKNNEPLVDDERHASHSTWSFEAIASRWLCGTSSSGDTVEKTNSGQLIASVVESWLISVAVVQGLVISDLASIIKPACHAVVWSALLFAKYAVTGASDCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XNN3</accession>
    <name>A0A6G0XNN3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_003109</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000034">
        <property type="protein sequence ID" value="KAF0741923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XNN3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000908"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0741923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="416" mass="47724" checksum="FFE08473DDE94FA7" modified="2020-08-12" version="1">MVYLQPFLAEPHGVKASRKVIGELRAMNKNYMCATCGHSTKQFVPPPDKPSNDDSISKWEIIEHLPPPVSRAKRELFCPVLCQNIVDEQTLCLGYPFRIECTHYTLSIDLFPEFLSFKAYREACVARDKSGFDMRTPSGHTYTHWLPLYLSHDNYNSNKGLHQAEFTVATTNGLQCILIVDLLTKAMNRQVLAVMDGSGHESEAAIIAYANLLRLLRHIVTEHPEYQQAIDRIVTEFISDPTKRLKKYVPNLGEFYVKLCVSTAASIDDVNIVEILVRKSFARQIRWIRQQDHECLDDDSMEIPTRLSRLFKHSTVSNKIMIFAMEMAKVFGQPDFDEKMDAHFGLPVEDTLIDFQNRVKHVKTSIVDYQSLVRAWGLERLIQSDNDMLQWMLDAKDQSVASKYNSKPKLGRIHGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XP71</accession>
    <name>A0A6G0XP71_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CREG-like beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_002878</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000030">
        <property type="protein sequence ID" value="KAF0742213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XP71"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005774"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055343">
        <property type="entry name" value="CREG_beta-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13343:SF17">
        <property type="entry name" value="CELLULAR REPRESSOR OF E1A-STIMULATED GENES, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13343">
        <property type="entry name" value="CREG1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13883">
        <property type="entry name" value="CREG_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="CREG-like beta-barrel" evidence="2">
        <location>
            <begin position="77"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0742213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="243" mass="26431" checksum="787C2B59636FC119" modified="2020-08-12" version="1">MSATTPLLDTGAHSATPSRKWLFSTIALASCLAFLAVNFAPTWSTPATLNLRTAMTVESFSGLTPEESRLVHATDSNTQSARHARWIVHSNDWATIATSSIHLNGAPFANMASYSDGVGTSVENATGHLYFYLTPLDSTGKDVVKSPNVSVSITMAQLGNCKMDPQDPTCWKVVFSGPLLPVEDNDARQDALEALFSKHPQMASWPDDHGFEPFELHPTEILLLDFYGGPKLIAPSDYYAVHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XQB7</accession>
    <name>A0A6G0XQB7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_002494</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000026">
        <property type="protein sequence ID" value="KAF0742594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XQB7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014231"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045218">
        <property type="entry name" value="DA1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022087">
        <property type="entry name" value="DA1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24209">
        <property type="entry name" value="PROTEIN DA1-RELATED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24209:SF7">
        <property type="entry name" value="PROTEIN DA1-RELATED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12315">
        <property type="entry name" value="DA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="4">
        <location>
            <begin position="31"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0742594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="371" mass="42496" checksum="AB9FDF855269310C" modified="2020-08-12" version="1">MVATCTYLAAPPFIMHELQEVNLVRPDILLTAQSVCSFRPGSSYVQAFGNIYHSGCFKCAACSNAIPGNMRFNIHENEPYHPQCFQELYHPRCSVCDERLPMTPDGRITYLEMPFWQLKYCALHEQRDRCCSCRRIEPTARSKHFQSLSDGRKLCGDCTNTVVIDTEEVQPVVLDVWAFLASLGMHLPEVPVFLVDFETLNAQSHTAHLNLPRDSKTPVVYGVCLSEVVQFNHFAHRAIQKLFRLENTRRVNGIMILHGLPYDMTAYILAHEATHAYFKLHEGFPTSLPPKVEEGMCQLMGYLYLQYRKVMAPEDEPQFLKQLRDWYLQSLVEDASPIYGDGLRDALHSFNLYNSLQNVLDHIRQASAFPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XQD1</accession>
    <name>A0A6G0XQD1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycoside hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_002360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000025">
        <property type="protein sequence ID" value="KAF0742658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XQD1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006453"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.40">
        <property type="entry name" value="1, 4-beta cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016288">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036434">
        <property type="entry name" value="Beta_cellobiohydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34876">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34876:SF4">
        <property type="entry name" value="1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01341">
        <property type="entry name" value="Glyco_hydro_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00733">
        <property type="entry name" value="GLHYDRLASE6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51989">
        <property type="entry name" value="Glycosyl hydrolases family 6, cellulases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026318483" description="Glycoside hydrolase" evidence="2">
        <location>
            <begin position="22"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0742658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="398" mass="42931" checksum="4B3FFAAE908A1299" modified="2020-08-12" version="1">MPRRLSLALAFLLSMAVAAQAGDDLPLCGTIPTSYVLARETYPKLKDAIDLVGKQPVATWWTDNNPTYISDVQTLLDTCSKNSLPVIVVYGLPQRDCGAGFSNLGKINSTEAYLEFIKDLVGRVGSRPVLYIMEPDAIGAAADGTGCAATNGYLDNMQAAVPLLTANENARLYFDVGFWMLNSAGDATKISKAVHYVGSKSREGAVKGIVLNTSNLRQTAEMLAKCSLFVEAASVNTTYKCAIDTSRNYRTPNTTTEWCNNKYAALGVPPTSQTGHSDLLDYFLWVKVPGESDGECNTTQQSADAMVGPRAGKFFEKAFSMQWDRGYFVDKKLGKPLREYDLGSDFTLPSSGLSGGAIAAIVISCLIVAAGAAYFVRRRVYPKQKTVLVEASTPQVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XQP9</accession>
    <name>A0A6G0XQP9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_002343</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000025">
        <property type="protein sequence ID" value="KAF0742640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XQP9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002922"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051685">
        <property type="entry name" value="Ycf3/AcsC/BcsC/TPR_MFPF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44943">
        <property type="entry name" value="CELLULOSE SYNTHASE OPERON PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44943:SF8">
        <property type="entry name" value="TPR REPEAT-CONTAINING PROTEIN MJ0263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="114"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="50"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0742640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="304" mass="34323" checksum="7CAA9E893F041218" modified="2020-08-12" version="1">MVRQLSRKPQSRRHTILMYTLGFCIPALVIVLALLAHDGQEHTLAHAKVESTSTSSIQAEQQSRAQDAKTTKYTDVQRRAVKHLQKAMGHFEAQKWPLVLEECEKAIQIDPDMVFAHALMGNALNVMMQWQQAVDSWRKATELDPSASEFYYHLGFALSQHSQDQLSTQRKFDLGNEAITSFERYLVLAENDPEATQAQMSLAHANLGSLYKANKLREKQVRALEHFEAAATLDPTNELAFFNIGLMYAEKYEKTPDESFMELAIQSVERAVELNPKNKQYAAIRDALVGKASPAELMAVMQQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XQU0</accession>
    <name>A0A6G0XQU0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Band 7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_002334</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000024">
        <property type="protein sequence ID" value="KAF0742791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XQU0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014712"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08829">
        <property type="entry name" value="SPFH_paraslipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000004">
        <property type="entry name" value="Putative membrane protease family, stomatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050710">
        <property type="entry name" value="Band7/mec-2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327">
        <property type="entry name" value="STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327:SF10">
        <property type="entry name" value="STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Band 7" evidence="3">
        <location>
            <begin position="28"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0742791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="327" mass="36877" checksum="1DE798639E5FEC1F" modified="2020-08-12" version="1">MDGTGALAIILGVFVGLPLLRFLILLIGNVIVVRHKETVLVERWGRFHKKLTPGFHFLIPFMDKVKTITWRRLKIQMPNVPDALVDKSFYRIDARQTIMDFKVQTIITRDNVEISVRPMVIYEFCDSMKVCYEVYDLSQAIKKLVQTTLRSIIGDMGLDDTLASREEINRGILQKISHICFNWGVRIHRVELLEIAPNASVQEAMHKQLSAERVRRAAIVTAEGYREKVKTEAEGESQAKIALATGEQQCMIIHARAAAEARLLIARAEAEALTLVKDSLKDMSVDTTQYMIAVRYIETLGALAKSSKKCEVFMPMETDVVGAIAVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XQW3</accession>
    <name>A0A6G0XQW3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine protease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_002219</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000023">
        <property type="protein sequence ID" value="KAF0742817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XQW3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010066"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.980">
        <property type="entry name" value="Serine carboxypeptidase S28, SKS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042269">
        <property type="entry name" value="Ser_carbopepase_S28_SKS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF117">
        <property type="entry name" value="SERINE PROTEASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026349752" description="Serine protease" evidence="6">
        <location>
            <begin position="16"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0742817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="483" mass="53835" checksum="9BA672663283861E" modified="2020-08-12" version="1">MVRLLSAALLASATALFLKEKKTIDYFILKESAGIEDAQATVPDLWFENQLLDHTDPSNKKTWKQRYHVNSQWFKGGNSPVFLYINGENVAHPTTVTTTSYFMSELAIKYGALVVSVEHRFYGQSQPTGDLNLESLKYLTMEQALADLANFQKYYVSQNANLTSANKWITFGGSYPGMLSGFAMSKYPDIFAGSVASSAPIHTKTDFFEYSEKVAYGLKYFGGDACVNTIAQGFKDLHELVAAEDTSKLNSLFNLCAPIKNDLDRMTVELGIFGGFRDIAQFNGLQDYSLTDVCNDFAAGSGTPIEKLANWTKVHIWDSSKCTGSDYKAEWLDYFSNTTVSDNIDRQWVYQTCAEFGFGQTTAKSNSLFGVLKYGTVENVYYEVCKDIYNITNTEDRAAATRKTYGSLQIDVANVVWPTGTIDPWSALALSNSSKPVNPRSEVVDIPGTAHCCDMFHSRYNFAPQWAHDRIEAAVVSYLHDKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XRB1</accession>
    <name>A0A6G0XRB1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_002151</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000022">
        <property type="protein sequence ID" value="KAF0743094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XRB1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009983"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000286">
        <property type="entry name" value="Heat shock transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="6">
        <location>
            <begin position="23"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0743094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="277" mass="30712" checksum="D4EBF0EB47D6973F" modified="2020-08-12" version="1">MPTTTTPPHSPQAAASPKKLSAATPPFLAALYEILSQEDPAVIGWCDDGESFGVYNVDEMETNVLPVYYRHNKFSSFQRQLNYFGFRKVLKPRAPEPSTFYAQPLFLRDDPSQMLRIKRKTYRFKGGHALRRNGFDAAAGRKRRSSAPETPLPIVDEVNIPLWQDDLPAPMARQSDSRKTSRSRASSESFIALMANADWADLAVPSNDTIMSCLDKLLEGSHIEKPVQAPSQAKSGAPLSDNPFEPIPFAATQDDGWKLQDEDAALLSTMTKPLVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XRB4</accession>
    <name>A0A6G0XRB4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_002150</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000022">
        <property type="protein sequence ID" value="KAF0743093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XRB4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009985"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="6">
        <location>
            <begin position="18"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="147"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0743093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="259" mass="29326" checksum="9317593A17FA9F29" modified="2020-08-12" version="1">MSDSLIRRKKSTPELSIATPPFLAALYDILNQEDPSVIGWCDDGRAFGVYNIQVLETRILPAYYRLSKFASFQRQLNYFGFRKIITSRSSSEPGTFYAQPLFLRDDPARMLQIKRKTYRAKGYNSRRSAAAAAQAKYLQPAEYFNEPSHTVEATEEESKPRRESVAETKTTTPSQRMDDKRWPEFKMDDDDANLGPYLDFMLERDQQAFEADSKEEYFMSPIPFNQGGSGGDGLLDEDILLLTSLISPSNSDGSSGSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XSE3</accession>
    <name>A0A6G0XSE3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BD-FAE-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_001884</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000017">
        <property type="protein sequence ID" value="KAF0743411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XSE3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011695"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049492">
        <property type="entry name" value="BD-FAE-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF33">
        <property type="entry name" value="KYNURENINE FORMAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20434">
        <property type="entry name" value="BD-FAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="BD-FAE-like" evidence="3">
        <location>
            <begin position="117"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0743411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="398" mass="44888" checksum="AD201A223A3AD280" modified="2020-08-12" version="1">MAMAREWRKSREKFRLAQLDTANVDDDGELSINELRERQQCAIDLADVSAEVWLLTKLAMQLLWAFRVSTKWIVMLLKLLLFVMFLLPAFLRIFHFWLFSPRVVKNIRYGPRGRNLLDIYLVPHPKKKQPVVVFLSGGAWIIGYKAWGALMGRVLSAHGILVVMPDYRNFPQGILPDMMEDANTAMEWVFQNIHEFGGDPDNVTWIGQSAGAHIGACTIIEAVENPKFASWKPSRLRNFIGISGPYNIQESEEIFHEHGLDRQVFAAIMNHDVLRYSPTDRLLELPKATAALFPTMHLYHGTADLTVPSSSSAKFAAALSSVGINVKIKYYAGKSHTDPIIEDPMQGNDPLVHDILDIIQESTPPKATPSPPREHVNVPPSAMLPAWMVNCARRVNPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XT31</accession>
    <name>A0A6G0XT31_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Multidrug/Oligosaccharidyl-lipid/Polysaccharide (MOP) Flippase Superfamily</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_001730</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000013">
        <property type="protein sequence ID" value="KAF0743586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XT31"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019739"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13132">
        <property type="entry name" value="MATE_eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045069">
        <property type="entry name" value="MATE_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0743586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="482" mass="51826" checksum="C751E7AFADB7E657" modified="2020-08-12" version="1">MTVVQEESAALLPKKAPIVDDSATIESIALDEMVAMYHLAYPVVFTYVLELTPGLISLVLVGQMTAPDTKRFVDAAALSVMYLNVTALSVGIGLATAMDTLCAQAFGAGNIRHIGLYLQTGTIVLGVAFVPIFLANFFCEDILVFLNQPPDVAALSGAFSRILAFGLPFLYAYELLKKVLQSQNIAHPMLYSAILCNMVNLVIGYLLVNHTAMGYLGAAISRTLGNIALPLSLVPYLMKRGDMQFWPGWQLEAAVRGAPEFIYFGLAGMLMMVFEWWSYEIIALLAGLLPDAIVAIGANAVLVNITATVYMFYLGVAVAGNIRVGNALGSNRPKRAKIAACLATLLAGAVSLVTGLAVFFFRYAYPRVFTQDEAMIELAARVGVVVAGFQLVDGLNGAIQGVLRGCGLQNYGASINFVSYILFGLPVGYFFEFTVGWGLPGLWIGMTLGYTFAGVCGTVVLFKMDWQTLSDQAQARANSKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XTX6</accession>
    <name>A0A6G0XTX6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_001538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XTX6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011331"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050697">
        <property type="entry name" value="Adenylyl/Guanylyl_Cyclase_3/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43081:SF1">
        <property type="entry name" value="ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43081">
        <property type="entry name" value="ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0743896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="587" mass="65717" checksum="1B6067E87919E8A7" modified="2020-08-12" version="1">MADDAMLSDYGFPKWVCVYAVVLGISLLASSVASWTLYKYTKVVTSCVCYAMLSFFVWKSIYSLFRVIVLVFAMRQYQLRHSNWLTLDENHDVGGFRVIGYPDPLHPGQKQPPYYVKVPLYIGDTAMLSGAFWMLVLVIELLRLARRTVDRGSKAEKKFLRMYICINFAILVVYLLGSFSSSILSEDTNGSQFYASRFQMVLIASCTAQTIVIFLVSAAVIYLNCAGLKFESVECRVVQKPLYVRLKRIFLIYLVTALPYLAVGWVLAVNPKTVLLWVKDIPNEILVLSNVLYVTSPCAFAFVLVANQKCMLSLCMVSDDVVLLEIEANEAPREFPVFVNTDIESSSALWSCLGNVMHDAQDLHDNLLRRLLVPHHGYEITTAGDSFQLAFHNIADAVAYCLDVQEQLLLEPWPTEFVESSMPGSATILAPKSNVLKRTKTLFHGVRVRMGIHASDAAEGDLVSSVHPITGRVTYVGLSELIGREVSDLGHGGQIIVTAPVLRWLRQNMESNSTWAIEHPCVFHELGVYHISDLKIDLGIAHIVPMSLKERADIFGPIDSIQRTVGYTGRLSNNYELLFSPKVSHFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XV27</accession>
    <name>A0A6G0XV27_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_000878</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XV27"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012046"/>
    <dbReference type="OrthoDB" id="10267824at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000020">
        <property type="entry name" value="60S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.950.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000006">
        <property type="entry name" value="60S ribosomal protein L8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="entry name" value="Ribosomal protein L2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01320_A">
        <property type="entry name" value="Ribosomal_uL2_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_uL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023672">
        <property type="entry name" value="Ribosomal_uL2_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_uL2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_uL2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_uL2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Ribosomal_uL2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007180">
        <property type="entry name" value="PRK09612.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="RIBOSOMAL PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="4" id="KW-0934">Plastid</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL2 RNA-binding" evidence="8">
        <location>
            <begin position="11"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL2 C-terminal" evidence="7">
        <location>
            <begin position="96"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0744396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="256" mass="28091" checksum="063EA1640DB2C91B" modified="2020-08-12" version="1">MGRVIRGQRKGAGSVFRSHVKTRKGKAAFRTNDYVEREGYIKGVIKEIIHDPGRGAPLARVSFRDPYRYRINHELMIAAEGMYTGMFIYAGKKAAMAVGNILPLSQLPEGTIVCNVEARIGDKGKFARCSGDYAVIVTHDEDKGKTKIRLPSGSKKTVPSACRAMVGVVAGGGRTDKPILKAGRAYHKYRVKRNEWPHVRGVAMNPVEHPHGGGNHQHIGHPSTVRRDAPAGKKVGLIAARRTGRLRGIKKLEKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XVI1</accession>
    <name>A0A6G0XVI1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_001148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XVI1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008403"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0744691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="104" mass="11726" checksum="7F9698D91C827D2A" modified="2020-08-12" version="1">MYEKPRKMEDSTPRGRDAMRQEVPCGAVTTREEEPLPPMADSRREIELPDDESTKSIEDILFDDEVEEDMMQFSPALVADTTATPTMETVAASMKSLSVELDQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XW61</accession>
    <name>A0A6G0XW61_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_001145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XW61"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008207"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052050">
        <property type="entry name" value="SecEffector_AnkRepeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586:SF3">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="770"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="780"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0744688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="792" mass="88494" checksum="315620FE835A654E" modified="2020-08-12" version="1">MQGERTVHGGLLTLLPCIQAFQAGVHRDFIPFLVLQTPKQHNPFNNFALDHPKFEKLNAALTPWLDEYGLSRLPTLFKAMSFMKQNVLLHAVYEGHLHLVEHLDVHFDLLQAFGLNLIDIAASRGHMPLVVYLHERGHPGCTKVAMSGAAQNGHLDIVRFLHAHRHEGCSRGTLEIAAREGHFEVVVWLYGNEIDLCTDVAATFAAERGHVAIYEFLLDHGAYEPRELMDGKVFAKRINADLATAAYHGHLAMIMYLCDVLCASWTSEAFDHAASQGHLDLLVEFSSPDVHGSDRALEDAAGNGHLHVVEWLLEQKSGLEARRSMDRAAQNGHLDILERLFKHGFKDCAAASFDKAPGAGHLQALQWLHDKLHQTGTPRSIDAAAARGHLEVVQWLVAHLYPDHAVNLDAVAANGHLETMQWLHQHHVVSCSHRAMDTAASNGHLQVVQWLHLHRTDGCTQAAMDGAASEGFLSVVKFLHENRQEGCTTDAMDKAARRGFLHIVKYLSKNRTEGCSVMALRRAVETGNVDLVRFLVHRHPNPETTRLLDAAAAHGPLEMVQFLHEVENSTCSVAALDNAANNGHLAVVQFLLDHRREGWSSRAIDQTLSIPVLDLLLERQPSVRSNMDNLMTFAASHGYLHVVQWAYDHGNLSRIPSRVMDSAAEYGHLQLLQWVHAHPNEGCTARAMDRAARKGYVEVVQWLFDYCNAACTTDAFVDTAFRGDIRTLSWLCDNVPSPERQCKARQVAEEHSQPLVVEFLRSPWRYRRKQRNRATATSPERLEATETRDSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XY96</accession>
    <name>A0A6G0XY96_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_000168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000001">
        <property type="protein sequence ID" value="KAF0745719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XY96"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015451"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0745719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="333" mass="36515" checksum="AE213513EE1503AA" modified="2020-08-12" version="1">MAASQLHKTFLKRAVASQKLRGVLVDYEVLCESTVQEAAAPASSLGSEKTTIDETQSMKRGSLFQNVRGLLQSMTQSETEQGRRVQTTLAGLPTFMRDRILGDNPNRSDEDDNTASLHDKLVNEMEKKPTKATASKIDILQTEDKADGIRAKYLDKINAIKQRAKAKSTSGDESTISTTPVAPTAPSTKGTTSSSLPTRKVNEGVNAFLSYISLRGLALGVIPPTSAQRQAEFEHFVTDLKYLDAVMDNADLAAFPQPTPIHNVCKLLDLEPKDIVVISSSKTAILSGKAAGSHTCYVLKHDADYNHDCEYKIPNLREFKYIVEELNGISWRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XYL1</accession>
    <name>A0A6G0XYL1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">15-cis-phytoene synthase</fullName>
            <ecNumber evidence="2">2.5.1.32</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_000161</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 (2E,6E,10E)-geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:34475"/>
            <dbReference type="ChEBI" id="CHEBI:27787"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58756"/>
            <dbReference type="EC" id="2.5.1.32"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.32" evidence="2"/>
    <dbReference type="EMBL" id="VJMJ01000001">
        <property type="protein sequence ID" value="KAF0745712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XYL1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015444"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31480">
        <property type="entry name" value="BIFUNCTIONAL LYCOPENE CYCLASE/PHYTOENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0745712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="302" mass="34757" checksum="5FACCF682F76AE12" modified="2020-08-12" version="1">MMHRSFIQRRYISKQAMTLRENVRKLDYDNFLCGLLLPNPSRDAFFAIRAFNIEIARVKDNVRTNPGAGKLRIQWWRQRIHDIFHVSKAPTDHALLTELHTAIHKHKLTKRWFDRILEAREWDLDIENPSTIKDLEVYAEKTAASLLHLTLECLDVRDDTADIAARNAGISIGITTLLRGTNFHASNKTVYLPQEVLTKHNLTPEEVIQAAIDDEAKDLRSKLTPAVFEVACIAVERLRQAQAAKPQIPRAAIPAFYTTVSSQRFLDRLESCNFDISNPDLHEARPLNLQLALLKHSLFRYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XZ22</accession>
    <name>A0A6G0XZ22_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ERCC1-like central domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_000224</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERCC1/RAD10/SWI10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000001">
        <property type="protein sequence ID" value="KAF0745777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XZ22"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000427"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070522">
        <property type="term" value="C:ERCC4-ERCC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22325">
        <property type="entry name" value="ERCC1_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000017">
        <property type="entry name" value="DNA excision repair protein ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047260">
        <property type="entry name" value="ERCC1-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004579">
        <property type="entry name" value="ERCC1/RAD10/SWI10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00597">
        <property type="entry name" value="rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749:SF0">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749">
        <property type="entry name" value="EXCISION REPAIR CROSS-COMPLEMENTING 1 ERCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14520">
        <property type="entry name" value="HHH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03834">
        <property type="entry name" value="Rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC1-like central" evidence="8">
        <location>
            <begin position="67"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0745777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="261" mass="29036" checksum="A3F5942EF999D7E1" modified="2020-08-12" version="1">MSTPPEEARSKVDSRNEVQSGFNDEMPRYLSRADAFNSIFQGVGNPAAPTTSQTEKLVKATAGTMVVLVHPSQSGNPMLQHMHNVLPEINADISTDYMMGDACAACFVSVRYHMLHPDYLKNKLSRVSKVRVQVLVCHVDVPDNESALKDINREALHAGYTLLLAWSWKEAARYIETLKVYENKSASLIKEKIDNDFNSQMNDVLTTVRSINKTDVLTLSSAFGSVKRIMNATEEELALCPGIGGKKVQKLLETFNQPFQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W2T4</accession>
    <name>A0A6G0W2T4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ae201684_019222</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000511">
        <property type="protein sequence ID" value="KAF0721134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W2T4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014753"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0229">DNA integration</keyword>
    <keyword evidence="15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="13" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="14" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="16">
        <location>
            <begin position="278"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF0721134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="450" mass="50520" checksum="404105225D70F162" modified="2020-08-12" version="1" fragment="single">MRRVNTASKKGHKADKCFMKRRHQNDLDQANKRAHIVESNLSERFDDDEAMDMKTEGSEDWKWSGSAWASRASTRGLGELKYEWVVDSGATHHMCYVLEMFDQMEASTKSKANTVGLPNGGHVAVVGVGSVILTVKCDLTDQRVKIKLNGVLYMPKFNRNLISVRKSAKAGLKFNFETTEDHLVVMSNSQSITVIGDPQEPLYILKHIRADESLEKAEANAMMAHPTFDLWHKRLGHLNPVAMKRLLDKGVVRGFKVVQSDLDGWICDACELGKKTRRVKLPSSAASVNRCNAKVHSDLTGPIETPALDGSRYVCLFVDSHSSFITCYCLTKKSEFNELLVQHRAVIQNKHNLPLSELHSDNGGEFVNKQLKDFCAKEGILHSTSVPYTSQQNGKVEVRFRDVFAKARSMLIDGNLPKQLWDHAVQCAVYCLNRCPSGTRKTTAFELWHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W3B4</accession>
    <name>A0A6G0W3B4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_019152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000423">
        <property type="protein sequence ID" value="KAF0721399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W3B4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006952"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0721399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="320" mass="35317" checksum="79EEB54463B3AF4C" modified="2020-08-12" version="1">MRRHLQQCMARYQGIAWLDGYYRPCGGVECPVVHPAGITWLLARWLKLRKAEMSIVNMAFEILFHIVGFSAQSSVVMSILLIFQSYSDALYQAPLLLISFSNCPSCGPAKMRRSSLLCLLLALTSFVCVESRAMFHDAILSKLYDKVLVKDREGKCKKEEMKHNVNQIATNCAGLSAAVGIGLACSGSSQGAVVAGGVTTSIVTLKSQLDSYIDARCARLVHSASGVAKLKKAMPKINAVNAFKNPKGHPAIVRIPISHGFIPFLWFSSDILENNAFVSSTHAGHLSRIDSRRLYEKGPRLPWHNPRRYLKCRSSIDSYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W4G5</accession>
    <name>A0A6G0W4G5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_018822</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000358">
        <property type="protein sequence ID" value="KAF0721919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W4G5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016398"/>
    <dbReference type="OrthoDB" id="75621at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0721919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="136" mass="15533" checksum="D60F8E071EFB9F4F" modified="2020-08-12" version="1">MEEWEDVKTWFKQAPEWAPYAAASSAAALLVCLLCCICRLTCCRRRRSNYEAITKDLEEEEREFEMSLSSDDDDGEGRSIEFNDDELKQVEMLESYGNNLQTQVTIDEVTPKANIEPMSPTAATTSHRIKKTLDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W4K9</accession>
    <name>A0A6G0W4K9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carboxypeptidase</fullName>
            <ecNumber evidence="2">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_018757</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="2"/>
    <dbReference type="EMBL" id="VJMJ01000352">
        <property type="protein sequence ID" value="KAF0722007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W4K9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016323"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF201">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="475"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0722007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="521" mass="57665" checksum="214C6E20E000E93E" modified="2020-08-12" version="1">MTASSAAQDGNPHKITSLPGYDDPKPINFDQYAGHIELPSNRQKMFYWLVESESNPASDPLVLWLNGGPGCSSLGGFFTELGPFVVESDLSVKRNPYAWNRKANLVFLESPAGVGFSQPVLNVSNYNDDFTTDRAYEFLAQFLATYPAYKGRDFYVTGESYAGVYVPYLVYKLVKEPIAELNLKGYAIGNPFTDNIVDASAYMDYFYSHGLISIEMFNQGKAACGPRGVANCFYGGDVCPAACLKVINEAISSSEWENAQALNQYYLYGDVCKLNNSQGQTLTNYNIRPLTHRGKYGPCNDKFTELYLRSPAVQAAIHAPNVTWTDCSDQVSGHYTRAPSSLQKYPAILKAGLKGLIYSGDADSNVNFLGTERWLTKEGLNLTVVEPWKAWFGPDKQLSGYSTKYTNVTFTTIKGAGHLVPATRPLHALYLFECFVYGQAACSGFYYPKDPLEYLSGADLTAPVLDESETTPVSYLWWALAGVIVVVVVFVGWRVYAGQQSKKDKVQYTELTSEAKPVYTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W5V8</accession>
    <name>A0A6G0W5V8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_018316</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000330">
        <property type="protein sequence ID" value="KAF0722583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W5V8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002169"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0722583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="410" mass="47460" checksum="84C7B9C9F84D937E" modified="2020-08-12" version="1">MPAASWIATESTAGELLGSYERRLVEKYRFALREIIDHMTFFLHLFRQAHAKLIDIESLAQRKLPQMLPFLNVVREKFVYIAQTTPFFLGYDHLVAYVKMLQQERQYLDPRPQPWNSMRLYDTDYQDHFADKILVFTMLCEELDEKLPVFQASIEAHAAPLKLLTQKREDMLSLLREGHNASKLPTNMKKHKADVKLAYEKSLLKYKEALQASPIKLEKQIQHEIRFFTQHLNSMLAPHWNICRTLKRANAETSRDETLTAHERQLVDDFLEEILRLNDEIGDFCSVAMTKEAFLEQVSAFEKAAANDLFVVCMVSLKLNFCEPLDQPLFGAYCEDLKSRMKELHTLRNSNKFQAAVANCDATRVEVSVCYHKMQQLENNGNLHEETKQETLACLKKDIQTLAAADGLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W627</accession>
    <name>A0A6G0W627_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_018260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000327">
        <property type="protein sequence ID" value="KAF0722661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W627"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018207"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08267">
        <property type="entry name" value="MDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050700">
        <property type="entry name" value="YIM1/Zinc_Alcohol_DH_Fams"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695:SF294">
        <property type="entry name" value="RETICULON-4-INTERACTING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="13"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0722661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="315" mass="33475" checksum="D6E3BD32DD0CB156" modified="2020-08-12" version="1">MPSVNYNIFSSTGRTFYPEPAKATLKANDSVVVAVKAAAINPVDYKLPKWFLHGRAVGLDFSGVVAEVSPDVTTVKVGDRVFGTASGALADKIVVSTSTIAKLPTSFSFKDGAALPIAYLSSYQALVNHGFTEGMKVLIIGASGGCGTAGVQLAKALGASEIVGVCSKKNEDFVKSLGADRIIDYQTQSIVDGHEKYFDFVLDTATSSGGGEDYLDSAKAVLKDPLKNHVLLNGPFSLLFAKFTGLGRKDVALIICEQKAADLESVVKYLELSNSRPVIDSIFPFTQEGVEEAFAKLHSRRVKGKIIINVSGDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W644</accession>
    <name>A0A6G0W644_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_018396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000332">
        <property type="protein sequence ID" value="KAF0722487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W644"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019800"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051707">
        <property type="entry name" value="PI-Interact_SigTrans_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336:SF8">
        <property type="entry name" value="PROTEIN OPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336">
        <property type="entry name" value="TANDEM PH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0722487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="123" mass="14011" checksum="E66C7F916B690AAB" modified="2020-08-12" version="1">MEVKSGILFKRGEGGLFKRKNWKRRYFKLTPTEFTYYCPNTGVVKGTVDLSECTVGALEIMPEDCPKTGKSASTEWRVAINTPTRRFFISAPTEFEMQEWVDALMIVLQAFEKTRGSLCDLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W649</accession>
    <name>A0A6G0W649_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_018779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000355">
        <property type="protein sequence ID" value="KAF0721957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W649"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005532"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF600">
        <property type="entry name" value="PDGF- AND VEGF-RECEPTOR RELATED, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0721957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="230" mass="26261" checksum="27FC3C8AFFABD00D" modified="2020-08-12" version="1">MDSSDLESIICKEITTWKSISKEPHILTLVGVCTKAPAPIVVSELCETNIRRYVRDWPESLLPLVYQFACGLASLHAAKIIHRDLKGDNVLVTFQRTVAIADFGLSRSVTSPKTPKANKRAGTLNWMSPEQYFEPQTVTTKSDVWSFGMTLWEILCNETPLRRVRAAEFEESVFKSEDDRPEKPEDMDPALEPLWTLITNCWRLNPDDRPSADKIVEFLQSHYDSQVEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W6L9</accession>
    <name>A0A6G0W6L9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_018105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000320">
        <property type="protein sequence ID" value="KAF0722874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W6L9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010650"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0722874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="184" mass="20391" checksum="9705DCDAFC40682C" modified="2020-08-12" version="1">MSFNLHNVSMHVMDYTVDETVVYYKLELVDETTGDCTSVPRRYSAIAAFRQALLKEIEASCECPAQANSCKPFVAALKQCNFPAKTWFAKDGIQSDLVAQRATDLAFFLQDVLSVVREWTPLCPSNQAFLEKSLADILGTSLVIAPRSRKGERSASCELPMSSSQPFQRNRSGSVPMTAKPMIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W6T2</accession>
    <name>A0A6G0W6T2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RxLR effector protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_018875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000362">
        <property type="protein sequence ID" value="KAF0721839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W6T2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012699"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026201582" description="RxLR effector protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0721839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="134" mass="15135" checksum="B4F0B90D91ADC594" modified="2020-08-12" version="1">MRTTTFSLALFAVLAAGYHAANEGSIQLVNAHDQAVADKLHLDFATFSKLQSEDSGRKLINIKDAIMEIKRKRKQHVGNEKERAEPNKDGIQRFRDKLREMREKKVVRSERPKARNAASNDIDANQRSISSSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W743</accession>
    <name>A0A6G0W743_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Acetyl-CoA acetyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_018527</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000339">
        <property type="protein sequence ID" value="KAF0722311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W743"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002084"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000007">
        <property type="entry name" value="acetyl-CoA acetyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF156">
        <property type="entry name" value="ACETYL-COA ACETYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0630">Potassium</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="8">
        <location>
            <begin position="21"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="9">
        <location>
            <begin position="286"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="6">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0722311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="409" mass="42915" checksum="F653E0BB9E6D85D5" modified="2020-08-12" version="1">MQARMKMMSRCFSTALAPRDVVIVSYARTPIATFNGAFASLTGPELGAIVNKAAIERAGITVNDIQEAYLGNVVSAGIGQAPARQSVLKAGIPESVPCTTINKVCASGMKAIAMAAQSIMAGSQDILLAGGFESMTNIPYYLPKARSGYRLGDGKLVDGVIHDGLWDPYNNQHMGNCGEKCANDFGFTREDQDKYAIESYTRAANAAKSGKFAAEIVPVSIPNRKGDPTIVTQDDEIYNVKLDKIPSLRPAFKKDGTVTAANASPLNDGAAALVVMSAEKAKALGLKPLARILGFGDAAQKPVDFTTAPTKAVPIAAKHAKLTLKDIEYHEINEAFSVVALANMQLMNLDHSRVNVNGGAVALGHPIGMSGARIVGTLIHILEQNDATIGCASICNGGGGAGAMIIERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W827</accession>
    <name>A0A6G0W827_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_018504</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000338">
        <property type="protein sequence ID" value="KAF0722338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W827"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015634"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
        <property type="entry name" value="FYVE_like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="START" evidence="6">
        <location>
            <begin position="147"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="5">
        <location>
            <begin position="268"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0722338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="437" mass="49857" checksum="F9EC3A8D08F3B98F" modified="2020-08-12" version="1">MPPAKVPLRPDFFQCPPLSREAIQRYADLGRQSAKTLIQKAKLRDGAIDWKMHKDESELKIYKEESCTEIEGPPRYCGVMQVVGELDEFMDLFRYDTTEQARESYRRFVGPFVDTMVLYTVHHRNPFRPNDSTRIKWCLAKSPMEGLVPRRDFVILESDLEFKVDGKRAWVRSYRSVELSSVPDLRKELNCVRGEMTDMGFVVVESDRNGYLDMTYVADMEVNGMAQFLAIDSALKWWLRYMTCIDHVMRENRLSRTPFLTYSQLCPLDGRSMCSLCRQKLSSRRKKVNCFKCGEVFCRNCSPLWNVKLEGLDVPMRACLPCSLNSSDLSSWTQNSSISTIGPPPLPPAVPAAVPAAAVPTAIPAGIHAALHTQTSDWALLESHEDDSTVDDDDIFFLHTPTHTEVARYHPVNPIILDLPAMQEEEPDELNTYKMSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W9I3</accession>
    <name>A0A6G0W9I3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_017253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000290">
        <property type="protein sequence ID" value="KAF0723980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W9I3"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34211">
        <property type="entry name" value="CALCINEURIN-LIKE METALLO-PHOSPHOESTERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34211:SF3">
        <property type="entry name" value="CALCINEURIN-LIKE METALLO-PHOSPHOESTERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="659"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="712"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="742"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="846"/>
            <end position="873"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0723980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="996" mass="114392" checksum="D1ABCC7840C60E30" modified="2020-08-12" version="1">MPTAQDQWAWFLVFTTVFLSFYIFTSPFVENRELLDRWTVYVYFSMGLYTWLLSAVAVHVPLTELGMMDYDVKQPVSLFLPIFFSSIAILVAFQTALYLLKRFGWVTRFSSLSWNRLVSTIIRNSAAVSVSCCILIVHCDADDEDANFPKTYNRHACEHLFGASSSPIPVPASYQGAFFIWITGLTLAMVNFVFERLVGFQVFAMHWHSDDDEDDGNAHATLPPEHALPMVPWYSMFMFDTGFQLLISLKIFLGRFDKRVMQAALHPNYREYMFDHLADKDELWFDFMADCGDGFNSSYQIARMLAQPQLQVNIPPSNAKLRHIHGDNLNLPRGNCLVLGGDLAYPHPDEESYESRFWRPFEYAMKPPIWYDPAAVSTKKPALPKQCKTLKDYEGPTCFAIPGNHDWFDGLNTYSRFVCERDWLGGWHLPQDASYFALKLPQGWWLFGCDLALEHDINVEQFACFEAIVDKHMEPTDRVIIVTHEPNWILDGYEERRSEEKLQYLIQTILAGRVVVRLAGDIHNYSRHSLMEYDIPPPPPRTPSNFQKKRNLTIQTSFSSENLMQYSGPMSPFSPVAKHFPHMNDLTHLYPISHDKVEAPAHLIVSGGGGAFLHPTHVPGGENLVARQRFYSRASCYPSEKVCRRYAFLNILGFRRLNWRFDIVGGLGYFCLAFSMFPRCSVGHIYESGSWGSTILSFFCELWDIHYEVLTTSYLSLATFIGLMVGHGLFADSPSLGKRIMISIFVSICHSIAAFSVLIAFESTFQAATDRGALGTDGLYALYKYYQVHVPDMVQLRPYDYFNLMPLYSSCVKYILTMFDVPQAGAVYRMKICSEGFDSLSRSEVLIYYMSVFLYFWVAATPICGVIFGMYLCMAVNVFKSHYNEAFSALRVASYKNFLRLHIKPNGDLEIFALGIDKMPTKWIRDPAWSGAAEARKLSPQPSYTWAVPSYWKPTMSKVDNILRFDMEEEYFDHKFNTEDRSRVKLIDYILYQKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W9U6</accession>
    <name>A0A6G0W9U6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_018039</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000319">
        <property type="protein sequence ID" value="KAF0722964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W9U6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010205"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="193"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="129"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="255"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0722964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="288" mass="32734" checksum="5A539028D19043E5" modified="2020-08-12" version="1">MDTARVNSDGVRYMSVSEQLLDMSMNKQLPGKLDRHALEKRLMELQGDVSRLVTKLSTRAKDETSVAIAHESSVVRLSQRAKSSISVRQVQEKKPPAAALNTTKTSIPGSRMGNLIRLQSELHATRLSNDKLRFDLDQMRRTMEAQQAKLREFQELQAAYRQLQEHCASLQQSLDLSETIRQRQKKMLHHLKLSKSTSSLGAPELPSPPNDNQLDENIGVQKHWRTPPPAPAQTRKTIATRTRPKPKKTKLQRVASANSSFLAPTQASQQRLAETRQFLRQQQLDHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WAW4</accession>
    <name>A0A6G0WAW4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Vacuolar protein sorting-associated protein 29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_016929</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the VPS29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000272">
        <property type="protein sequence ID" value="KAF0724387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WAW4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020729"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07394">
        <property type="entry name" value="MPP_Vps29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000015">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028661">
        <property type="entry name" value="Vps29"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN VPS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="6">
        <location>
            <begin position="9"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0724387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="191" mass="21340" checksum="6D1D946C9CEF9CC0" modified="2020-08-12" version="1">MAADFGELVLIVGDMHIPHRAVDIPEKFKKMLVPNKMQHVLCTGNLVTKEQFDDLRDLAPNVHVVRGDFDENMNYPDKKVITIGQFRIGLCHGHQIVPWGDVDCLAALQRKLNVDILVTGHTHQFKLHTQNGKWFVNPGSITGAYSNCTTDVVPSFILMAIQGAKIVAYVYELKGDNVVVSKSEFVKEDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WB04</accession>
    <name>A0A6G0WB04_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase M20 dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_017739</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000309">
        <property type="protein sequence ID" value="KAF0723400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WB04"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015313"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014:SF63">
        <property type="entry name" value="METALLOPEPTIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G09600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PEPTIDASE M20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0723400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="21170" checksum="08575B4F58483C99" modified="2020-08-12" version="1">MVLLTTTLHFAAFFADLAKIRRHIHANPELSFQEYKTQALVRDYLIHQAHIPAEQISVSGKTGLVVDIFGPKEGPLPAEAVVKCVAFRGDMDALPMTEHNSHLEYESKVPGAAHMCGHDGHTVNLMGFGHLVQQRRHLLPPHSTVRLLFQPAEEGHFGAPAMIKDGCFIAVSRRMILASSQFVKSMAGKPTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WBE3</accession>
    <name>A0A6G0WBE3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_017042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000276">
        <property type="protein sequence ID" value="KAF0724229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WBE3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001308"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016071">
        <property type="term" value="P:mRNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028322">
        <property type="entry name" value="PNRC-like_rgn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15365">
        <property type="entry name" value="PNRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0724229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="231" mass="25840" checksum="F0B9440C6008B6D2" modified="2020-08-12" version="1">MASAAKKDLIGRPLVPFFTDEGHVNDTLELSRTMEHEHMDVDARVWNAAQGYFEYPKEENEQGYTAPARPIKSAVLLTPQRLETSIKEVRSQSREKKPTPVPTSTQAKVTTPVEQPAPAPQSKKKTKKSSPNNESKDKNKKGDAKWAWSSFQNSPDPKSLPIPPFLSPSPLPQQEPEPTPVMPQLALNVEKKPPPRKPPNQITILQRPKPKEEQMTLHLRQMLNIGVDPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WCT3</accession>
    <name>A0A6G0WCT3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_016629</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000264">
        <property type="protein sequence ID" value="KAF0724755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WCT3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013420"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="5">
        <location>
            <begin position="265"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0724755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="357" mass="40170" checksum="7A218F8F6C8519DE" modified="2020-08-12" version="1">MPFPLPADFFRCPPLHPDDEEALRTIGGQNSIDVIRYARLENGPIKWSLDADDSDLLIYQGHDPYAPPGVVSWIGITEVMANLTEVSSLFHADTHDAFRDKYQAIFTDVLDVATLYSLNAPSEEFPRHFLGVRWQVMSSPAAGVAKHRDMCILESHHDFEAEDKRGWVIAFKSIELSACPDLYSTLGLVRCVHHRSGIVFTESVRPGYLMVAQLIQCNLGGSAPSWFMGMTMKRRCRLITQLTQHIRLARLNGSHFLAEDELIPRAARSRCFLCQKGFHLLNPKSRCRKCGEVICRSCSKVWQILVAGLPTKLRICTACAIATDAYEALTNSIMQDVMDDDGRRLRPQSGSNFSLWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WD45</accession>
    <name>A0A6G0WD45_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_016256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000247">
        <property type="protein sequence ID" value="KAF0725239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WD45"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001631"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34859:SF2">
        <property type="entry name" value="LYSM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34859">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026062930" evidence="1">
        <location>
            <begin position="20"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0725239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="358" mass="37966" checksum="5257184E298322DA" modified="2020-08-12" version="1">MILLRYLVVVAFFVGFVDAKASKSIKAPSKAVKAVPKPANGASKSGGGEKKAKSSAGFCWKNSFGRGAGSIPQSCDPGQDRLGLLCYDKCPSGYSRKGLDCHQNCPSGFDDQGLFCRMKEYGRGGGYPWKFGDALNLNKARERCERDNGKGNCEQNGAIIYPKCKPGYDAFGCCLCRPKAFDCRKLGMQGQLDLSCSKFVQIGKPHVGKCPAGDENQAGLCYKKCKGGYGGVGPVCWAGNPSGWSNCGFGAAESSRRCAEVIKDQIMSVGQLAFNVVSGGAAKGLQSAWKAVKSKDVIQKAMKKISGKGFGVISKLEDSKDPADAVRLAAAITAMFDPTGVSDVVESFAFSTCDKVHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WDJ0</accession>
    <name>A0A6G0WDJ0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Carboxypeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_016132</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000243">
        <property type="protein sequence ID" value="KAF0725361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WDJ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010170"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF3">
        <property type="entry name" value="RETINOID-INDUCIBLE SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026325794" description="Carboxypeptidase" evidence="8">
        <location>
            <begin position="23"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="500"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0725361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="579" mass="64246" checksum="7D3866AF1FD6C1BB" modified="2020-08-12" version="1">MRACTFWPWIALLVSGSRVILRDEVPEHVAPASYRTWRNLESTNATNDRVNSTFGLDNLTHYAGYINVDPKNDGDLFYWLFEAQPDSSTESAATLPLVIWLQGGPGCSSMLGLFVECGPFRIVNETSVKMNPYGWHKAANMLFVDQPVGTGMSRVKYEAYPSTGKEVAAQFYSFILGFLKRHPEYLAANGTSTRSIYLFGESHAGRWIPQFSSYIASQNENHPLIHIRVDGVGIGNGWIHPIIQYDYSSFAHSHGLISIGQQASLQEEYAECIAAIESGNMKANACFLNLNNILTSIQGTTERLNVFDIRQYGNSIHYPPEKPKLMELMNQEFVRNILPGVPSATDLVFAECNSNLNRKLSAEDAVSTLSEISAMLSSGMQVLIFNGQWDMMCNALNTERLLQQLDWPGRENFGSARRISWHISSLDPPAGFVQSGGNLTHVIVRDAGHLVPYNAPEASLDMFTRFIRNRPFEGAAQSIRSSTVLQDDLCDLHNGRTSGVIIGVSVLVGMSSAVIASLLTLLCLRGQHNVVNTEDMDEEDLDDENGDDVVDDWDESTDMIEMAELNRSPKRRAKSTEPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WDT0</accession>
    <name>A0A6G0WDT0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_016830</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Folate-biopterin transporter (TC 2.A.71) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000269">
        <property type="protein sequence ID" value="KAF0724536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WDT0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018862"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039309">
        <property type="entry name" value="BT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585">
        <property type="entry name" value="FOLATE-BIOPTERIN TRANSPORTER 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585:SF5">
        <property type="entry name" value="RNA-BINDING S4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03092">
        <property type="entry name" value="BT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="533"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0724536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="586" mass="64539" checksum="C328755E6526F7AA" modified="2020-08-12" version="1">MNQGGLSDGRHGLEERVSYIHSATEEAVKAEYGEVKTPGELEDGALVEGGALNLFSLEAMALFAQYAAIGCIYGLIPSLQYPIFNNYLKLEGYQTASYSQLVTLGWSFKVFFGALSDCFPIFGFRRKSWMLIGWTITMVCLAVMAFSSLGEPYCNIEKATAEGRPKACSKIYSKTNDTDKVYFNLDAPDNGTLFIMLSVLVSFGYVMADCAADAMVVEYAQREPIAIRGRVQTAIYTVRQIFIIVANVIYGFGLNSPNYGGEFSFSMKPNVPYGILLIPAILVVLSTIFILKEHKKPGTPFKEYVDMFWGLLQKRVMWQICGFRFISNVFYNISTTASSPMYNTWANVAPLNDALSSVLGGAIFGAIMVVIGKWGLHWNWRYCIAAGSIGVMCVDAPINFITIWDVYRNQWFYNGVGLADQIPAGLRFIVATYCAVEIADVGNEGATYGLVTTVSNLASPFSSVLYKLIDSNFKLTQADITEDTYEVRMDVTYSYIISYSCKLASLGWLFLLPPQRGPMQELKRKGQVSKLAGALLIIIFLACLSFSVTSSIMAIFPSTKCYRIAGGNGKLDPKTGKCPAVASRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WEX4</accession>
    <name>A0A6G0WEX4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_015718</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000230">
        <property type="protein sequence ID" value="KAF0725948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WEX4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017491"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555:SF170">
        <property type="entry name" value="FI18122P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="63"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0725948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="174" mass="19775" checksum="D89198BB87FD56A0" modified="2020-08-12" version="1">MTLLDHLQQDLDIALTLGAVVTALLAVGFLGWCSYRARKAARIVPRRSSNSYTSNCSVTKSSKPTAINVRYTRDTLPIAGSYIVYTIELSWETKKKVVEKRYSDFDHLFASLKKEMKMLKAPIALPPMPRKSFLFNFDANFLESRRQGLQVFLEFVVRHPVVSEFASVRTFCGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WFG3</accession>
    <name>A0A6G0WFG3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_015543</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000224">
        <property type="protein sequence ID" value="KAF0726140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WFG3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016435"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="108"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0726140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="815" mass="90425" checksum="6C6D0020E29C59F1" modified="2020-08-12" version="1">MSGPRPGTAGLVLRRTRSQEIEYSSGVSLSSSIQPVPAPFAAYPPDISAVQQLGQQVQQAVEMQSSRLNDVQQAVGAQQQFTYEQLMTLHQKQQEQQQQQMALNDKLMAELEDQRKHQQLLVEQLMAQKQVAEAHERGLHMAAEESVKHEQQLEEMRRQRSACCHAFSAPPSPATAGVGVPPPSVQVVYGFHEVPKAPTFNGSTKVQMRKFMDQYEAYSRDIASANAQRPGGAKIHQVSLSACIDPLAVERIAFWEIGKPSDELTEEDWRVYFLSAKDCDPVDMGKLDQAMGKLRMDVSIQSPESRVSKLVSDFESNLVKLSMEGFAEAEPKLTVEYLVAAIAPTSVRSRVKDLLKLYEHRGLKKDARLFKAWLSDYMRRYGEFEPLIAKASAGGDKPKETNPQVKRSDKKAKMVAVANVDKVPVSNLTQDKRVGFKCLSPDHNVFKCPKVVDGEAKLLMEKARAVWRELADKPADKIASKPAKAVNVVKCQSVDNWDLAVGCAARVVCVAGRTVTLAASFDSGADQSVVPPKTLAKLRSEGRDIKVVKLSEPVLVKGFTGPAHSVTEEAVLQLRFETEAGPLVLSNVKCWVTDDDLPESVGDILLSRAIMCKLGFDPRSMLRDAASIASEYDMAGATSPSGVVLAIMLARQEMEDDLSMEEQELLPLEMDVCFPDVQADLDEEKTKVQSVLKEKIAEALASGCTAEFALKLEALLERYHNVFRLTLGRDPPVDMPPLKVHLVSGATPFRCKARRYSFPQREFMQQHVKELEAAGFIYRNPNSRWACAPLIVRKPHTKDEFRMTVDLRPVNAQTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WGJ0</accession>
    <name>A0A6G0WGJ0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_015460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000220">
        <property type="protein sequence ID" value="KAF0726242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WGJ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006354"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0726242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="618" mass="69890" checksum="AA4077BB28A274E6" modified="2020-08-12" version="1">MNMKPETFVLQITSCLCLLETSSEFRLDLGEFVDLETIFQVFQLDEVPDDILDQLLPLAVACLYVNAQNCEDFRYPGPSDMPSPQEDKHVAEIAAFTNRLYASESWCFVRSYMPIQDSMLHYNIDDAIIRRAIPFLELAYHAINIKSRIPVLSAKTASKTTKNCEVLCASESQHRQDVQAISANKKKYRIPVLSAKTASKTTKNYEVLCTTSLQYGVQKMKKQVATLGAKNYDVETKVPHLTSKDKRAAISTERLSFFDNKVSLLEASHKRQFQLKDNSSSSRVNYRDTTATNKNIYSCAEYHCDQAQTSPSTASQSTYFSEQEDPFNAEFRTINNVDDQPQAQQHSKTLTDANQRELVSTSILPYVPPQKVESSLLAKPHEAIQVLRQLKKDVGEDVQKYLKASKARKQTSEIYGLDANGNTSSNFSMKNQDQLYQDMQSAKCSAGEESQKFSDQSTILSKLPYLSAQMPPLEAHPLPRTKSSRTIIVEKYLKLEETSRDQKISGIYGVSNLDRLRKCLMKDDIKTSSHLATEGPPDQKADFVDKTSQLSEDTETAKASSNKKPSTSEFWLPIPGWPLEAESFDAALEYWRFNKPKDLFEPPVCNGFHCRRYLGKCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WH55</accession>
    <name>A0A6G0WH55_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_015271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000214">
        <property type="protein sequence ID" value="KAF0726503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WH55"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009001"/>
    <dbReference type="OrthoDB" id="73919at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051707">
        <property type="entry name" value="PI-Interact_SigTrans_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336:SF8">
        <property type="entry name" value="PROTEIN OPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336">
        <property type="entry name" value="TANDEM PH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="7"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0726503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="142" mass="16094" checksum="E39C11236D7577D5" modified="2020-08-12" version="1">MPYQQQPIVKAGTAFKKGSGSGLFHRHNWKTRYLVLTLDTLYYYDHEDGHLKGSVDLSTSNTSAVEVMPPDCGKTGHSGASEWRVAINTPDRRFVLAAHSEKEMREWVNAITSVLRANEIRWDHPEMHMRSPVSFVHVPAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WID3</accession>
    <name>A0A6G0WID3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_014943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000204">
        <property type="protein sequence ID" value="KAF0726953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WID3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004375"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0726953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="136" mass="14857" checksum="F17FD6CBEBA5CE66" modified="2020-08-12" version="1">MNASLNVSFAWQNQSNHSIVGGNETTADRSTLISIAAGNTSSTPVSNKMEVSQFDPDAITFPPRNMMPLDDKEETLHWKFDIVVSSVALAAVLIALVMWLRKRRQVSLSFYSVGGVDYICSCSPSPNTTTRFGPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WIZ4</accession>
    <name>A0A6G0WIZ4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_014701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000200">
        <property type="protein sequence ID" value="KAF0727170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WIZ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011253"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35213:SF3">
        <property type="entry name" value="MYB-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35213">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0727170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="272" mass="30784" checksum="01CE229FC98185B4" modified="2020-08-12" version="1">MSFMTSSTTAVPSTIPRASTPLPTLRVSIPIDSVASHANIQSLFTMGHPATNPQRRYLVNKDTRSKARPGLRKGKWTDEESRYAEQMTYYFKEGLLPLEKGTMLRMYLAEKLNCEPMRITKKFTGDECIGKQIFRPLPPSPTLEQRIHQALADLQVLEKAFLERIEEMPMYCMSTKRLDKPKRSKKPKTDKMDKEDAPDAQAASLLLGFFNQTQDTAESPGHNYQPAKEEAPSLSPTPYRSTRKFSISHCVHEYDASLKRPRIDSLSVVASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJT0</accession>
    <name>A0A6G0WJT0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_014515</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000194">
        <property type="protein sequence ID" value="KAF0727494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJT0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001689"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061700">
        <property type="term" value="C:GATOR2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016239">
        <property type="term" value="P:positive regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037590">
        <property type="entry name" value="WDR24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46200">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46200:SF1">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21720">
        <property type="entry name" value="MIOS_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0853">WD repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="93"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="182"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0727494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="703" mass="78939" checksum="26E7569B4571FB12" modified="2020-08-12" version="1">MDFTGPLNAVSISQSQKFIAVGGRDVLKIVGLESTGFVERRNLRSSKSNLNFSTNDIRWHPQSDSMLATAATNGYLILWDIQRDSSKMNKREVKAHDRAVNRICWHPTDPNLLLSASQDGLIKLWDQRLKGKNVNIFQQQKSESVRDVKFSLFDDSKFAAAFENGTVEIWELRNNRHPEIKFPAHQGHILSLDWHPSRPGFIATGSRDRSVKIWDLSMNPNYIKPVQTIALIANAGRIQWRPNCPEQIATSSSITDSRINLWDTQRPFVPLACMHGHADIVSDFQWIDTPRVQLSTNPSDSTSDVEGCDYWQHVIACSKDKTLTLHSLADSVKPHQSMHTVALTMNTEGQIVSSHDAIDRSCSSLNIHQHEHASNPLFSVASTTVAMQRNARKVKSAANLVQMPRMSSFKAPTRKNTSSGSLPSVQASFASNEPVHHNTTLDSPIPPPQGMVSVASFKNSVSYQEFRDVLDGKSVLSLLANDRITPQIFGFDEQVFRFLARSYVLYDESFQQMCTQNAKVASVAGCSHLSKTWMILQLLYEKRTTAYHKDATLMDSENTDTQWFNQHPSSTQTSKLLAQLDEVNPMHGVDAYPYDEVKDTSTEALQAQQASAQSVDISRVQDTLLKELLDYYCEAGDVQSCATIAAAMNTVTNIELIMGKGWLQQVYMHYIDLLHQLQLYSIANYLVKNCPDLGIRQMNMVFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WMU6</accession>
    <name>A0A6G0WMU6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_013591</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000175">
        <property type="protein sequence ID" value="KAF0728632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WMU6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019366"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="entry name" value="tt1808, chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="249"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0728632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="287" mass="32411" checksum="E80A5F57BEE33F08" modified="2020-08-12" version="1">MNNQPKRLEQLVHDLKTKKCLCCARDYPGITLDELNQYVEEHGPLVNPLFGEQPAFFIDEDHFTPYRMVVYGCAIVVAKIAELVGDWAKWSTHSGRVITGQGAFILEQTTGTRKVRMPDVAYAPRACQRNVLAQHVWACGSGPFAPTFVVEIDKLAGKGSRRQALDLKMRNDYFQHGVQLAWLIDPHPQHRIMYVYSIDAEGRVHCDGHSTWRDLDGGDVLPGFYLHKTDLDMVLHQDSGSSSEGEVDVECPYPGCGRQFTSLGPFCAHVEWHRAERARQKFLAKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WP40</accession>
    <name>A0A6G0WP40_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_013231</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000169">
        <property type="protein sequence ID" value="KAF0729095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WP40"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012247"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031464">
        <property type="term" value="C:Cul4A-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14255">
        <property type="entry name" value="CEREBLON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14255:SF3">
        <property type="entry name" value="SULFITE EXPORTER TAUE_SAFE FAMILY PROTEIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026258285" description="Membrane transporter protein" evidence="6">
        <location>
            <begin position="20"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="434"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0729095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="506" mass="53571" checksum="64798F8A77FC51B3" modified="2020-08-12" version="1">MRAIQAVAAAAIAVGLCNASAQLNGVSGLACTKRSDCGLIPSLGCVQGHCARCVVDADCAESSSSSIKYRCAIKNGEPQCLNKDVFSPFTGSDVLASILAAFATAMGAACGLGGGGLLVPLYIVVVGLSPKFAIPLSKATILGGAVSTFWSTYNNKHPFAPRRPLIDYATSALMEPATLLGTIIGVMANVMFPSWLILALLILLLAFVTYKVVVRANKMYAKENADALLPASSNNDTQECIDPACEDENGGVQTAEDIATKKLFTKESRVFPFRSYVLPLIVCIGAILGQSLLRGGHGAPSAVGIKCGSAGYWLLLLPFGAILLGVTYWMGKKQLDREKAYEALGLETVEGDVKWTPYKAYVLFPLQCIAAGFASALLGIGGGMVQGPVMLENGITPLVQSASTSYMILYTSTSTTIQYTIAGQFPGQLQYDFVCWYVAMGFLGGLFGKTFVQVIIKKTGRMSYFLYFLALNSVAQAIAMGYIGIRDVVHDIQKGASMGFSSLCHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WQE4</accession>
    <name>A0A6G0WQE4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_012878</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000163">
        <property type="protein sequence ID" value="KAF0729613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WQE4"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0729613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="69" mass="8088" checksum="8AC837731592DF41" modified="2020-08-12" version="1">MGDRGCHFDFKQREVAPNCQNLRRNSNRTIVAVARRVGRRNKRFPLDMTLRFFAQDSSSRRHGKKIANV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WQP1</accession>
    <name>A0A6G0WQP1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_012649</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000161">
        <property type="protein sequence ID" value="KAF0729758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WQP1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007270"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="483"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0729758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="537" mass="60216" checksum="A3C31E812FC24B03" modified="2020-08-12" version="1">MHPPYGEAAIGHVCRQHFALFFQHPMWTSFGDRDLALPAVAATSSALLGWLLLRHAWKVYQLSAIPQPKSSSFLFGNLLDSYGQVAQWHETGSYPEPFLSWVKEYGNAVRMREFFDYTIMVADPKAVQHLFSTNASNYHRTSVVEDYLADFTFGHGLLSTRGAVHDAYRKMLNPLFSAAQVKKFVPIYEAQARHACETVFAPAAASGEVLNLYTVFSDLTLRVIGLAGFGFNFEDHPEAHAAYQMVQQEMSPIILIGLATIPGFVKLPLPSFQRRRRAQVVLRRVVNEVIEKKLAEKVNEDKPKDLLDLILPHSTTREAIIHTMTFLSAGHETSSSSLTIIFASISSRPDVIQRIRQEYKDVMAKHGSLTTWEAVSQLTYTMAVIQESMRLHVVVLALARRLGVKDDYLPMDGRDPIFIPAGTMVEVNVAALNRHPKYWDKSDSFIPERFLEGTPEWDVDLKLRDGKPHAFYYVPFSIGSANCIGQRFALAEIQVILAIVVGQFDFKVAPGSNLNQRHHGATMATAKVEVTLQKVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WRD2</accession>
    <name>A0A6G0WRD2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_012589</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000159">
        <property type="protein sequence ID" value="KAF0729950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WRD2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009830"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0729950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="306" mass="35435" checksum="49A2A8A8D1FCD856" modified="2020-08-12" version="1">MARFARYEKPSDVDSLERLSQKLTADLRNHIRFMGDYPVLSTEWKEMANNMMRFGEISEMERNLPKQENATLWECEELALRYILEDGKLNLCLRLLVEYKDFEQGSIHRVLDEETHRITANFERGLGVMLKNAWLHVEALQTTDLPLLLNYIASVLTFCEENPQYVESKDLADSQEVIVIHYLLGLFKQLEHISESRIMPIVQEKQIFALLVSHVERHWRLFHPHDVHAAMVVLALMCDTEDFQTHAESYLSSGATCRSLSALQDEVLDELTHDDLDTRKELRPLLDVVLQYASGRSSTSSSKARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WSA3</accession>
    <name>A0A6G0WSA3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_012306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000155">
        <property type="protein sequence ID" value="KAF0730306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WSA3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018366"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="528"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0730306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="596" mass="67660" checksum="7208BEF978E788FE" modified="2020-08-12" version="1">MASVEEKGDTAKKKQWKTNEVPTRNRSRGKEKPAERKEATTPRSRSTPSKDRLPQPNARNVTANVIAKLTPAELEQQLQEQLTSCRFEDAAAWIKASPYLSEKYQLADVVRLVLDQRHFDLAGRLIREHKLAENQQLVTFFIMELVRSGRFHLAVRYAQELVPQFNGGDEHVTDRPMWTPTTLVMAMIRAQQYKTALKYAKQFNLETEFPVKKFVQGMLHEKAWADAFAVIMEHNMEKEFPIDILITNMLSERQWSAAIKSIKMAKRGDVFTTKVLVQRMIQSGDFLATLNYLKEFSLTDDHDLVRQMLNSMLHFDELYKAIKYSIKFGLAIEPAYNPSRLIDLAIDRRQFHVASLYIKKLKLENEFQDDLRHIAHEKDGLLATFRALMARKRQRQRSPEYQARLRECLGDDYEEPEEEIDIVLSVEEEIIPRKAPAPKTSLLERLHLHDNPSSLSFLLQDMKGLGGSTSFADADSAFAFAPPAPRPLVVQPPLPPPQLQSRPPFPQTAPSPPLPRGPPPPPPPPPQSSGFYQFQPPLPSAAASLAMQFHVPPQQPLLPPPPFPLAPPLPSQPAKPHRTFVPSLSLKPSQLGPKHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WT08</accession>
    <name>A0A6G0WT08_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peptidase M13 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_011998</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000153">
        <property type="protein sequence ID" value="KAF0730576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WT08"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002952"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF167">
        <property type="entry name" value="FI17812P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="9">
        <location>
            <begin position="145"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="8">
        <location>
            <begin position="564"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0730576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="774" mass="83990" checksum="99EC9411CA175099" modified="2020-08-12" version="1">MTSEYTSLLHNTQQAQAAERPWWFKYAAAGGVVAVVGGVVWATTGGSHGTTEVINQGLGGPATTVIPTTTAATTSLPTTTVAPATTTATPVATEVPTTTVATSTPVPNVTSDTIVFPGTPEPTHPAEFAAFFQDLADKMDLSVDPCDNFYQYACGNWLNKTELNASVSRIDSSFYVIGKDNDKILKSILAGKPAIIDPFYQACVSETSVNGDAVVDLSVKLLNIANIATVNDLIAFAGKLSVVSSTESFFSVGVTVDAKNSTVHVLELAQGGLTLPSIEYYAAEQLPTYVAALDKYLKSLSAVEAFHAVPASTILDFEAKLAKISLTQAQLRDPWGTYHKFSLAEVLAKYPLIASYLSGAQPELLNETNSIQVEVPTPTFFEALPALLASTDLAVLKAYLSFRLIYARSTLLGEAFREPTHEFNSALNGQSSVTKQTREEFCLALTENILGEYLGKLFMDKVFDSHTKTQAQALIKQIEDAMVDVVNQDTWLDTPTRRVALEKVAKIRNFIGGPNDVSPLPFNISSSFYANMNHFNEWSTNSTWASLHEPVDQTAWDMFAYTVNAYNQPSANKIVFPAAILQPPFYNAKAFPAVVNYARIGMVMGHELTHGFDDEGRNYDPQGQLNSWWTDNVAATFDKNAKCLADQYSTFPVISAVDKKTVLGHVNGKLTLGENIADNGGLKLAYIAYQQAKKANASIADIGYDDAKLYFTAYAQTWCEKRVDGNALLQINTDPHSPGKWRVHGPLLNSQSFADAFQCPAGSPMNPVKKCVVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WT25</accession>
    <name>A0A6G0WT25_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_012067</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000153">
        <property type="protein sequence ID" value="KAF0730648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WT25"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013133"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="699"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="955"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="966"/>
            <end position="976"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0730648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="976" mass="109551" checksum="98EAE883E8943550" modified="2020-08-12" version="1">MESFLHEALSPSGRDVLNEFFQANAGSKSSPANHTFQTLPLITDVVCTSRRVSEVVSLTVNIHGAIIVSKIAPPTLNKKHPVSEMENIDLIRKDDILLSINQRPVDNLDEAQEWMQELPLPLTLVFSRAVVRKNTLGEYTLDDLRRHAEHNRSRLLERNSPADVAQILRIMIEFTQSEGSYRMLKDFIGEAEAFLMPLTPPTSLTDSFDTVKRYILQMHEYMATEEAGKKKRWLEDKHARAKRLESMQRQLKVLEAKLVSSTAAQAKSTHVSQEYLDLRSLVDQLRLDVEQSKQLHYLPECEGFTLRFGTNGVYAGVSDVWISSYHTSFTIETQRSAPQVVLRLTPLSDTGLKIRAMNFKVFSEGRMMLVPTFHVDEINIEVQFAADIPLSWDAVTGWRVDAEALHINFSSLKYYERQTQSNLHGKTHDSVMKTFLNKIVPSVVQEAAASVLCGEVGALLVDGRAKVRLSGDLHIEGRNLEVFDAALGSESSSDVANEARSLVGCTQTEGDVLFKLYKLFVAKTTKKKDSTHLPHLSIRELVEYGVRMRQSPSVRALLGACWQLAIQLIDEQSSLVFTSLMDKVAQMETYPVDISLGFHSTNIRIDLCEATAAAYTAMDRILRHKLTTRVELKQEIEEELTALEETYNQVNVWLSTVASRIDELVVLVSGGLPAGFDSKLSFEASEMTCKGPWQANLDIPLTDLSVPPPPPQPSTSNTKTRTVISQDKGDLVVSQFVQGEGDEQEHELQVRIQDAAFKVLLDFPAEAQVGGQRLEAMEFKLETTGAEKPNVSLSMGDFAKCAISCKRLAFCAPMWTVVKLLGNAIKSHVVLDYLRSPYFAFSLNFFTSLQVTPEQMYWTLNSASLSDSHVSYVTHRICVSQLLRDMSKKEAEAFDDATKERERLNRSQSTMVVDGAAPSKRGMLARQDTFFGDDDPRHHNMFQLEKLDAEVDEVEPLQEPVLDPTPPKDSDESYYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WU69</accession>
    <name>A0A6G0WU69_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_011590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000147">
        <property type="protein sequence ID" value="KAF0731041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WU69"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018481"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051556">
        <property type="entry name" value="N-term/lysine_N-AcTrnsfr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919:SF8">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0731041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="127" mass="14068" checksum="2E94DD94E9850BB0" modified="2020-08-12" version="1">MAALPGPVQGNVYKDALVESECSWVALKRGKVVGAVILHSENDKACIRTLAVDAVERGQGIGRMLVEKAIETALGRNQSLYLHVQVDNQEAIELYRRLGFTVAETLTNYYRRLASPDCFVMTRDARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WUL6</accession>
    <name>A0A6G0WUL6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SCP2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_011470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000146">
        <property type="protein sequence ID" value="KAF0731209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WUL6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009814"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0731209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="27878" checksum="BB92DECE551C1F60" modified="2020-08-12" version="1">MMPSAGVCARQSAKLEELMNFLQFAVLDTPKRFKGVVVFTFFNATREVVCVRSVDTTSNVRVYASRPPPDTNAVDVGLTISDFLLMYSGELTAAEIAGLCMSGKVQLRWTAYGSLKAFADSFDFSVDKWCEFYGHFGLDPNYVEQIECTLPCCTGAPETTVEEIEANWNLVRDSVLIPAGAGALDWQLVTSLEISPMESPKKEVVAEFPSSSSTWLHLFQPHLVQVQDTVKRKMFNVKEYAEKFLVLLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WUN1</accession>
    <name>A0A6G0WUN1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="7">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_011482</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="7">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="7"/>
    <dbReference type="EMBL" id="VJMJ01000146">
        <property type="protein sequence ID" value="KAF0731221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WUN1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009802"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17960">
        <property type="entry name" value="DEADc_DDX55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="11">
        <location>
            <begin position="3"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="34"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="257"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="519"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="580"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="3"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="519"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="588"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="620"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0731221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="637" mass="72463" checksum="1CB0D45465804CEB" modified="2020-08-12" version="1">MKFEECQPPLCAEVLAGIAELGFTEMTPAQSATIPLFLTNKDVAVDASTGSGKTLAFVIPIVEMIRRRIFATQDDTAANVLTTKKATQLMSMVLSPTRELARQIYDQAQMFFTRVLPNEVRVHLFVGGTSVDDDMNALREAKGLVSVIVGTPGRIEDVLNRVATLDLVDFKEFEVLILDEADTLLDMGFDVSITNILSHLPKQRRTGLFSATQTQEVKALARAGLRNPATVSVQLATDTKTPSTLTNFYAPVEYDAKLSTLLHFVKEHPESKHIVFFSTCASVDFFGALLSHLLTDVMPIVTLHGKMQPKKRNSHYDSYVPLRHGLLVCTDIVARGIDLPDVDWIIQFDPPQDPNFFVHRVGRTARAGRSGSALTFLSANEDAYVNFLRIRKVPLEEMKLEVADKDTDAVLDQVKELQLADRDVLEKGTKAFISFVRSYKEHQCQFIFRFKDLDLPRVARGFCLFQLPKINELRALENVKFTAPDIGVKIVDIPYKDKAREKQRQKKLEEIAQAHQAEKVERFEKKQKRKAESQADQPRRREKKKGLHQQIVEEWDELEKEEHLYKKFKRGKITKEEYEAALNESDGEDKQAKKFAKKEQIKKKSSEEKANAAKREERIRARKKAAHLQKKQQKTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WV31</accession>
    <name>A0A6G0WV31_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_011394</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000144">
        <property type="protein sequence ID" value="KAF0731331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WV31"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013696"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.50">
        <property type="entry name" value="Protein of unknown function (DUF3228), domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021610">
        <property type="entry name" value="DUF3228"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38666">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38666:SF2">
        <property type="entry name" value="FLAGELLAR ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11539">
        <property type="entry name" value="DUF3228"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0731331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="198" mass="22531" checksum="850490F4B7CC06CA" modified="2020-08-12" version="1">MDIVLDSFSHVQFDDPNHQGTRLDWDKEDFERRVNQLFVESGSRLVDGYAPFCKHIFIPNFVGAKLGMARITDANRAFLKTDYVARVPTELPVSVLVRWFPSSQVEPQVAKYLDVILYSREQLRLEAKATGKPIDESVSAPWGIIYVKAQDVDYELPMDPITIFRNALGKEEGGSGMPCDPKEYMESVAFWSNHAEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WV98</accession>
    <name>A0A6G0WV98_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_011338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000143">
        <property type="protein sequence ID" value="KAF0731437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WV98"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003009"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052050">
        <property type="entry name" value="SecEffector_AnkRepeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586:SF3">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0731437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="452" mass="50592" checksum="BAC27F97D528EAC8" modified="2020-08-12" version="1">MGGGFQRPVGIAAALFPSFPSLLQAPNDDDCSLYSIGCQLWQQLVVGLAKETRRQTLVHSKIGVHLHTDGMIFTSPDVLQQIVAFQPGYAQDLWPFVAFLRAHYINRGVRPRHSSVCPNSLLLRDYAFLKLQLDAFQAVFDPWFAQNDPADLERLFRVDARLFIVTLHHAIATEKMEIIVYLHETNQIHNNTLHPTAIAAWMGSLHVLKYLHDHSLGDFKPGTMDLAAHQGHMHILRFLHENRSEGCSGNAMVSAAWQGHLDVVQFLHTERHEGCTTAGMDEAASHGHLEIVEFLHKYRREGCTNRAMDSASAKGHLDVVKFLHFNRREGCTTKAMDGAACAGHLDVVQFLHFNRTEGCTNRAVEAAAECNRDEVVDFLLQHRTEGYDPTNMYAFFRILDAKRRVEEARKMKTTPQKIVSTDDCTQPTTTSGANNGGGGWVGSILATVRRSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WW03</accession>
    <name>A0A6G0WW03_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">tRNA-dihydrouridine synthase</fullName>
            <ecNumber evidence="13">1.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ae201684_011001</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5,6-dihydrouridine(16) in tRNA + NAD(+) = uridine(16) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53380"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:53382"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5,6-dihydrouridine(16) in tRNA + NADP(+) = uridine(16) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53376"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:53378"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>5,6-dihydrouridine(17) in tRNA + NAD(+) = uridine(17) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53372"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="9">
            <dbReference type="Rhea" id="RHEA:53374"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>5,6-dihydrouridine(17) in tRNA + NADP(+) = uridine(17) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53368"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:53370"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13 15">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Dus family. Dus1 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the dus family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.-" evidence="13"/>
    <dbReference type="EMBL" id="VJMJ01000140">
        <property type="protein sequence ID" value="KAF0731697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WW03"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003547"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001269">
        <property type="entry name" value="DUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082">
        <property type="entry name" value="TRNA-DIHYDROURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082:SF5">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(16_17) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006621">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 13 15" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="16">
        <location>
            <begin position="33"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="35"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="218"/>
            <end position="220"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR006621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR006621-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR006621-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF0731697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="374" mass="42582" checksum="DD9FF122853BFC67" modified="2020-08-12" version="1">MTVDAASASSVRERAISRGWKLYNDLHQPKRIVAPMVDQSELAFRMLARKYGADLCYTPMFHARMFQEDATYRATAWQVEPSDRPLFVQFCGNNPDVVLNAARYVENECDAVDLNLGCPQGIAKKGRYGAFLMHEPEVVRSIVEKLSANLSVPVSCKIRLLPKYEDTLAFCNMLIDAGCCWLVVHGRTKEMNKHLVRECDWATIARLKKELPIPVFANGGIETDDDVVRCMEETNVEGVMSSEAILERPALFAGDKDKDGQRIRQIDLAMEYMELAKQFPPPEKFLRAHLFKILFQDLKVHTDLREQTGLAQTHDELLAICVELKSRQEAAPVPFTTEDSWYRRHRKQQEAADKKPKMEKCEDSGFADFSLLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WWB2</accession>
    <name>A0A6G0WWB2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">30S ribosomal protein S9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_011081</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000140">
        <property type="protein sequence ID" value="KAF0731779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WWB2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003064"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000001">
        <property type="entry name" value="30S ribosomal protein S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00532_B">
        <property type="entry name" value="Ribosomal_uS9_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023035">
        <property type="entry name" value="Ribosomal_uS9_bac/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_uS9_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001099">
        <property type="entry name" value="PRK00132.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US9M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="29"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0731779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="263" mass="29777" checksum="488DB9DEAFCB495A" modified="2020-08-12" version="1">MLARAFAGLRLGLARQPAAGLGCAGHVAGFASKKKRDDDDEDKSRDDDDDDKEDPDEIWYEEWGPEPEVDADNWFGFKGDLDEVTEDGTATWVQAVRNMADIHNERDAMAKRKRQEAHAKKQITRVVEVDEFGRAYGTGRRKTSSARVWVKRSATDGQGIIRVNKMDLVDYFARDTNRHEILRPFMEIDHLGNFDVYCTVRGGGLSGQAGAVRHGISRALEKFNPDFRPSLKSVGFLTRDSRMVESKKAGRKKARKSFQWVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WXJ0</accession>
    <name>A0A6G0WXJ0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_010547</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000135">
        <property type="protein sequence ID" value="KAF0732255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WXJ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005100"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0732255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="181" mass="20852" checksum="7BF4B9555B576CDB" modified="2020-08-12" version="1">MPVNTSNDLQELQDQCILPEARDRAGAAAENLQQDIVTQLKEQWSSHLSGYDSAWRIWAATILKRPRHMHPRLVQEQPPSGMLHYFRSVPNSAEHRCERLQRSLTLAREVVETSIRDFSTIEKDMEILMARVRSYVQTLTTKQEMIDSFLTEVVVPNNEDVIAATLQNIPNIDDTEHEEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WYZ2</accession>
    <name>A0A6G0WYZ2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_010111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000128">
        <property type="protein sequence ID" value="KAF0732780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WYZ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003563"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37471:SF1">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37471">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0732780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="482" mass="54834" checksum="32CA2673A7BF5CFB" modified="2020-08-12" version="1">MARHASKPAKKTMDYYLCLFAVVLPLRAIVYMTPVVMAGLIANQLGWMGTPLSLWLAIPLLAYCVIESTFTLYYLHSKEAAQPLHPNPPQIVTAHAKRSEPLPSALAFFEKLFAHIDDVPAFLEGHFYGVPFPQLTRVDLSHWCAFAFFSKSLAQASAEEIDEIHVMVTRMYQLANRVEPPVEPSSPPRKYLQPNLEPFQATARPFVIYFATMACNAICSMWLRWFGFQLYQATPEIRYWHRPARSTETTPLVFLHGVGIGLLTYVPLLWKLFVSETNRQIFLLDMPYIAMQLSDAVPEKEGTINVITSMLDRHGISTSVHWMGHSFGSIVMSWVCQEKPHLVHYLTFLDPIVFALWLHDGIYNIMYREPSTGFDLILWYFGSQEIGIARTMRRHLCWYESVLFPENLPRHPETKKVLASIFMSEKDCIINAPAVLAHLKRGAKIADSATSVPIHTAMWPGITHGEMILYPSTYADVLSTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WZD4</accession>
    <name>A0A6G0WZD4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_010189</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000128">
        <property type="protein sequence ID" value="KAF0732864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WZD4"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0732864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="79" mass="9660" checksum="E7736F6009E2F36B" modified="2020-08-12" version="1">MNDQTKAQLQIAQELMETRRWEAELRQKEIDVKTKEHELVRRKQMHDEIMKECSMMREMNIPVEQILKHVQDEKERLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X209</accession>
    <name>A0A6G0X209_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_009390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000119">
        <property type="protein sequence ID" value="KAF0733825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X209"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0733825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="124" mass="14372" checksum="311577C808AD2832" modified="2020-08-12" version="1">MVSSAPRPPPTPTRQYQSWNSTPWRCCRLLSPPPQPRSPTPLMFNHPIRSWWNNPFTLLPLQWWLRPLSYMKHQSCMRLSSTRPPHTSTSTQASINHLDQFLKSPMAGHSLSTLLRYTHAKAID</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X379</accession>
    <name>A0A6G0X379_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16 17">Phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="6 16 17">2.7.7.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">Ae201684_008928</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16 17">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 16 17">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 16 17">Belongs to the CDS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="6 16 17"/>
    <dbReference type="EMBL" id="VJMJ01000115">
        <property type="protein sequence ID" value="KAF0734323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X379"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017577"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000374">
        <property type="entry name" value="PC_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016720">
        <property type="entry name" value="PC_Trfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773:SF8">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, PHOTORECEPTOR-SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01148">
        <property type="entry name" value="CTP_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018269">
        <property type="entry name" value="PC_trans_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01315">
        <property type="entry name" value="CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 16 17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14 16" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15 16" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR018269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF0734323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="453" mass="52288" checksum="C763CF7279F4F53C" modified="2020-08-12" version="1">MSTARRRRGNKESLQSLSDPETPEERRRYEALKETNVTEDASESESDTGALGGQPLCEPRWNLSTKEKKVTLLVDEDKAKKWATFKTRTIYTLLMVVGFLFVVFQFKQVGCCLLVFSLQATMYAELVGLMFKQQVEDEMPKFRRLYHYWFFVCVFFVYGRALMPHFEVHEFDTLFGLYFLEKGFVNQHHTAISFALYTGGFVSFVFSLRKRKHYKYQFSQFAYCHIALLIIVVQSTFMISNMFAGLFWFLLPCSLIIVNDVFAYICGFFFGRTPLIPKLSPKKTWEGFLGALVITVIWSFLFSRFMLQFEMMVCPQLGFHLDFKACTPAEIFVPQVVEKFPFTVAPIQYHMICFAVFASIVAPFGGFFASGFKRAFKIKDFGSSIPGHGGVVDRMDCQIIMGMFTYVYFTNFIQRPDRISSSIRMLDRLNTDEQLVVFRHLQSLLAEAGVLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X3R5</accession>
    <name>A0A6G0X3R5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_008795</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000111">
        <property type="protein sequence ID" value="KAF0734553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X3R5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006574"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014340"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020474"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020839"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05483">
        <property type="entry name" value="retropepsin_like_bacteria"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034122">
        <property type="entry name" value="Retropepsin-like_bacterial"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF37">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13975">
        <property type="entry name" value="gag-asp_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13456">
        <property type="entry name" value="RVT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="583"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase/retrotransposon-derived protein RNase H-like" evidence="5">
        <location>
            <begin position="843"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="4">
        <location>
            <begin position="1034"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1202"/>
            <end position="1227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0734553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1227" mass="136196" checksum="ED5F87309598D742" modified="2020-08-12" version="1">MALDGYEERLRASVRLLASKLASTATPPVISEESDTNSLSTPTPVIWNISSPSPTIAPQVFFANEDSATMPQQLSLLAGERLGFWRTSEVDHEAHCQAFLDAKILNEPAVVLADTGANMSVLHTRFAKRLGLRVDASTKTGIDGFGNGSATTAGTVPIKLTIGDGLTYLFTIAVCDFGPVGFHAILGMDFLEKAGMIIDTVKREIQLPDDNWIPLVLQPIKYRRGRVDTVKTPRQIQLQPGDSVCIKLPSPRPGLTNSPEFWVQRGVRWVTTAIVDDSGTSRSYRVTNVGNSLLVLPPHSVVGAISAPGDRPNDHTMVRTNSLRYKEWKAAAYEGSYSTRYQRMRDQVMAGDCPEMPYTDRPPRAPPEALLTQSGIRRLTQTEADTRPGDVDTRKDFTGRDGHEAVLVDDNTKQESNFSYFVTEHHQGLPPPSIFTLQAPRPDLDQRTLPLEVVIREGVDLTSEEMESQLALIPEIPPQVPFDMDQLDYGEVGQSEEERQEMRKVLDKYKAYFIRSGNGLPPPARGTVCDIDVGSAKPIAHRPRRVRPEHLQKLFELLRGLLSYGLITFSNSQCASPIVIVLKKGGSDIRLCIDYRGINDLQELMRPPMPTLDAMLSGFHAVQWLLSLDNASGFWVVRATKRARLISAFICPLGHFEWTRMGQGLKNAPMIYQRMITNALYGFVDLPPGMNEVDEDGEPRDMFQIGHVRDASSMPAPANRPSFVDDISDGADSWTGVVDLTDRILQRLTYFNISISALKSKFGKTVVDILGHLISREGIHAKPRGLHQVLQMPFPKSLRAMQSFLGSINFYSRFNENYSIKASCLYEISDDQLRQGSVSSAALAAFGELKRAYASTPVLKHANPNLPFHVLLYVTNWAISATLCQEHDGLLHPVRFCGRVLKGGEPRYKHWEREILALLHVLKVCLYELRSNSLTVYSKHAIINWIRKDKQGRTDHLSWAAMLSPWTLQVLDSSNLQGLDGIPMLLASSLCPPSDSTMDDLTLYAPLKSTRSLTPVQQSLPRFTAEESAVIATFDGSIKFSERAGGFGAILWQLPEWTILWAGYGVVTDTTVNGAEYAGLLAVLSVAIRLHLTSVRVFGDSRLVIQQVLNRMRCTKPHLQTLLAEVHTLNNQLASPSFHHVKRVWNGAADYLASQGLTDRTTGEVTDSSTLDLLRSLNWLPHLVHDTRFPLPEHLQYLAQPDSTAASSRSRGGVVYKPGDTPHQFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X4H7</accession>
    <name>A0A6G0X4H7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WRKY19-like zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_008500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000103">
        <property type="protein sequence ID" value="KAF0734836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X4H7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003699"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056866">
        <property type="entry name" value="Znf_WRKY19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827:SF1">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24906">
        <property type="entry name" value="Zf_WRKY19"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WRKY19-like zinc finger" evidence="1">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="WRKY19-like zinc finger" evidence="1">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="WRKY19-like zinc finger" evidence="1">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0734836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="149" mass="15981" checksum="E47C51A9A7B586EC" modified="2020-08-12" version="1">MSCAKSSIEFLLNDNTEPVENATRRCTTAGCNSYVASKGLCIRHGGGKRCGVTGCPAGAKFYGLCWRHGGSKQCTVENCTKRSKSYGLCWAHGGVKQCAQPECTKRALQNGCCWAHGGGKRCYVTGCKRLAFARFNSRCAVHATTQSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X510</accession>
    <name>A0A6G0X510_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">S1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_008484</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EIF1AD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000102">
        <property type="protein sequence ID" value="KAF0735013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X510"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000064"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039294">
        <property type="entry name" value="EIF1AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21641:SF0">
        <property type="entry name" value="RNA-BINDING PROTEIN EIF1AD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21641">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1-like" evidence="5">
        <location>
            <begin position="23"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0735013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="183" mass="20535" checksum="FEDF5E0DD6964C06" modified="2020-08-12" version="1">MSGAGRRSGYRKGVTQDVLYGEPEPADGELIVRVQSMRGSNLLEIETPEGSTGLAMLPTKYRKLIWIRRGDYLIVAGATGKSKGAVNYIVEHILYKDQIKHLKKKNLWPEAFTVDEDTVLDQQANAEQKPNTIPPSAPLNSRDIVMDENHDDIDGQDDPMLFVNRNRMGGRYVEEESDDSDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X5B4</accession>
    <name>A0A6G0X5B4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_008385</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TTI2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000101">
        <property type="protein sequence ID" value="KAF0735175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X5B4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008554"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041389">
        <property type="entry name" value="Importin_rep_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057672">
        <property type="entry name" value="TPR_IPO4/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018870">
        <property type="entry name" value="Tti2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18829">
        <property type="entry name" value="Importin_rep_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25780">
        <property type="entry name" value="TPR_IPO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10521">
        <property type="entry name" value="Tti2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="11">
        <location>
            <begin position="27"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="9">
        <location>
            <begin position="400"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="9">
        <location>
            <begin position="441"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="812"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="822"/>
            <end position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0735175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1082" mass="118722" checksum="9C39046F0B502462" modified="2020-08-12" version="1">MADFAPEQLEQCILRLMAPDTQTIKEAEALLKQYLNVPASIVGMLTQLQGSSRPEVRQYAALLMHLKISSHWEQLDAATKAGIAQTLLQRVTEEPVSVVQVEIARNIAAVASEIGAAQWPELFNMITSCAGNPNAQARYLAMLLLNKLNETIGGELLEQFQNVKGFYMAGLKDTEMKVRVEAMRATCGIAHFLDENETNDKKTATDFQHMVEPMIEILKGCMASQQESEACDFMESFTSLSEIPFPLLTKSMPTLIQLLLQIFMAPDIEPSTRAAANSCINSIIENKPKVIAKANLAPVIFNTMIQAIAADNHSASGMFYSILQEEKEDDEEEHTTQMAQRTLDFMALSLSPKSMKPIILQCSHQIVGSSNPSMQKAGVLALGVVSEGMCEFLSENLSSVLPLVYTAAASPHHNVREAACFSLGQFAEYLQPEIQSHYADIIPVALALLDDPTPDVKATSCYVLEVFTESMEPEEIEPFLNGLVEKLVGLIQTQKPGIQKLAISALGSVSVGAKSRFEPYFGGVCELLKPFLAITDKKYLQLRATAIECLGYLVVALGAEKFGQTLQSIMPYVFDTMRFNDEELNDMCMGFIINASNIYKKAFLPYAETAVQLILPMLTPDNGVEICRDGDQKLEAFEDEDEIDATEHYFKVHTATTEMLTRAVQCIEALATNLGGGFDRFVPDILVALSLMVETIHESVRAVVPEACAALVVTSFYATNPAAEETKQWSQGQILELHPRTKMLLDKLMGPPLDTVEEPNQIQSVFQELLVDSDPNVVEGTLRALTTLTTELGAVVMAPYFEMIGHFTSQTLNMEHDTEKDDKDEDEEDEDDEKSTVLDLLTELFGAMAKAFGPGFLPLWQPLFPLFMQYLQVGVHADKDRAAILGAFGEILPEIQGTQYVAEVVPALFKGCASADTSMQRNSAFSLGAIVRMGGPSYGPQYMHLLQALAPHFNSKEEAVVDNACSAVASMISTAPDAVPLDQVLPVFLKALPLKADFTETENVYGALFKLLETQNPVASQHIGQIVSIFAQSLTDDSNVDEEVQVKIKGCVKWLVQSFPDQMQAVFGSLDAQAQAILQTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X5H5</accession>
    <name>A0A6G0X5H5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_008325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000101">
        <property type="protein sequence ID" value="KAF0735113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X5H5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001003"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0735113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="201" mass="22203" checksum="977A210F3FB7FB92" modified="2020-08-12" version="1">MGAASSVNNAAYDADKFAKSKAIMALECDDAEKFSKLKELWGGAVPEAATAAAAPKKGFVSKDDLEVYAGIVAEEPKKQDEKPSEAKKEPTPEPQPSKDAQAKDAPKDSPKKDDAKKDEPKKDEPKKEEPKKEEAKKDEPKKEEPKKEVKKEEPKKEEPKKDEAKKEEPKKEEGKKEEPKKEEPKKEAQPAQGAPASEIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X5L0</accession>
    <name>A0A6G0X5L0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Translocation protein SEC62</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_008172</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC62 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000100">
        <property type="protein sequence ID" value="KAF0735256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X5L0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015497"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004728">
        <property type="entry name" value="Sec62"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12443">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12443:SF9">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03839">
        <property type="entry name" value="Sec62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="167"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="234"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0735256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="332" mass="38611" checksum="9041614BAD42DE21" modified="2020-08-12" version="1">MAAECCDDHEHEAAPHVVAGPQTPEEEAEFKKVKKMADFLRGRKGMPVRQAIESGRRVEFFRGDKLGKFLINNKDAERYCPSPVTEKAHGIEMGQLLIAHGFIHRSLRDEANKKFLKPAKDTEFVADGYYTWMYDGPTTFRNFLTTLLIIGFTGLVCYPIWPQSVKVVVWYCSVTFLIFIFVFCIVRLFAFFILWLVGIEFWFLPNIFDDNLGVVDSFKPLYSLRNTDPSERKYRAIAFVLFLLMCIWIAQQPTDFDEYMELTKQFTDDIYSGKLLDDMSQSQRENIDKMKVPDLEELMKDENTDIFSEKDEEAIVDSFMDGLFNEDEKEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X6W9</accession>
    <name>A0A6G0X6W9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ketoreductase (KR) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_007771</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000093">
        <property type="protein sequence ID" value="KAF0735766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X6W9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014492"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF282">
        <property type="entry name" value="WW DOMAIN-CONTAINING OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0735766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="35796" checksum="89813296A5FC14FA" modified="2020-08-12" version="1">MDSMGDCSSTRDPFMLKWMDSTLERLVVILTMKSSKSCDYNETSPSCHFQLQTSQTKPDVTGGTAGLGLQSVIELARKGCHVIFTARNPTRGQEALEKIQAALAPTSFKVEFAIADNADLPSIVRFADAFLARNLPLHILLLNAGVGFTPYRAIHGVESTLFINHVAHQLLATCQWRVLEQSAPSRGNDSTQSYSNSKLALILMAHGLVEHFGSAKVYVNSVHPGIVATDITNRPMEFAHLLQVFASTLVKLLAMVYGATPQDGALMQLYVATSPDIVQHEWHGEYFVPIAKLDKASPLSNDRSEVKQLWTWTTAVIARVLAKSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X6X4</accession>
    <name>A0A6G0X6X4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_007952</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000094">
        <property type="protein sequence ID" value="KAF0735634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X6X4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009882"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.20.10">
        <property type="entry name" value="Crystallins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011024">
        <property type="entry name" value="G_crystallin-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49695">
        <property type="entry name" value="gamma-Crystallin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026141670" evidence="2">
        <location>
            <begin position="17"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1063"/>
            <end position="1080"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0735634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1103" mass="119909" checksum="207F28CB0581BDA0" modified="2020-08-12" version="1">MRPALISIALVVCGVAATVSWEKHVYRSLLGEAEAANQCPSWSGLDYYIVADSGPCLPYSVFDTDHWSVTIDHVPYPHSSFHFTFGKPLFPNGGVSPTSPSLVSPEGTKYPRVAVVTSSSKVADSDNVFHVLSPEVDYNWPDFQANRDAYVWTQLQPSNFTPGVYKVDLDAWDYLHDSGTCSLCFSLSDHYRPQSTNVCPDSALFNLTQTGWSSNVAYLTNYLALVENFTTSRTNNDCSTRPPTSCPDTTLLTGTDWFQCPLNISNATSPAAAFKINAGTCVTTKLTSNPFATDDVLANPASFLTPSQCTRSVSFDYKWYEYWVAFSCSGPSVSRCSSGADGADGGDATGAAKDAFECAATVSLAATADDLVKSVQVVQNASLVNHSQYITDPNGTFPDMNYSHVNQLHFWSPAVVKSVLTWDEFAPITFNIQDLLTTAVTGGGIAHLTDLSCCGHGVFWRWKQDNGPYKDYAANDQLNLTKLATEITFEAWTHCGVKTQNIVWTVYNHRHQTIKNLDEWFATSWSFDGDANCNIRQSDFTALRLHFDLSKLHGQVVDAADVGNGTTALLAAEMPSPVVLLDESDQVRWIFNDMKCTWKYGEKLTTDYSPSVNAWTLHSTDLVNGALDATFAPKLLNDATTFLTILCDLSFADTLSLTGLAVLYTGDFKGPSQAFGFGTYNLDAPFRHAVGSIKVKAGYEVVLYDGRDGQGNSTIVRTDTPALGLDDWGRAVSSIKVRECTLVVLLYAESLYAGAATPLGVGDNNLLNTNFSSFQMLPGYQITLYDDYNQEGKSITLSTSTTWLGALDWYGALSVRVESIGDTVATLWGGAFTGASTSFDAGHYNLQRPLLNNVTSITIAPGYEITLFDQLNQRGNSIKFVQNEILSDPWITTAKSIAIEPIPNSLAAKTTNIAHVFESTTFWFQNCDILTWGSDGIYENEECVNSCAVDSWKLFVDRVAGPFQACAGNLIYPDSDWSPDSVDPLSTVLDVSANHSCCTACNGQNGFKNSQTAVCTPANATAGISRCQPSQYDLVAEAAAERATPSNPGPGWSFVQVNVNSTVVSSIVMLLALVFVGVVHKSLANRQMSNDDHVYMSLTDIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X7C3</accession>
    <name>A0A6G0X7C3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_007752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000093">
        <property type="protein sequence ID" value="KAF0735745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X7C3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014473"/>
    <dbReference type="OrthoDB" id="78570at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0735745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="363" mass="40140" checksum="8931FDC3A0BC4AE2" modified="2020-08-12" version="1">MLGTLKNRMVESGKQLKSTLEEQSAEMNQRLQMMNINVNAERLTAVASSVVTSVAKTTAGTIAATSSPPSSTTNLGSKEPDEVAGGPFFASFVHRQQQVLLGHHALVQSGENLSQVLAQTRRRVTAEAQSVMYLQHNFQSITSIRDNIRSMRDSIQSLVVLMEDVEQLLMTKTEEHLVAENARFALQQQAELEQYEHNALVEKHARMQKRHEARQRALGEAFAKDLQAYHTIVTYQGQLPRSDAPVEPVIPLESIEIAIQPDTDLEAFYKEDVEEDIVVVETQVLAPDDDEETKEEAKEETKEVGDETKEETKEDGQEPVCLNDGAKENEEAKAASNSTTPGEDDKAAAAVPTLRLDGSDNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X917</accession>
    <name>A0A6G0X917_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_007509</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X917"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0736499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="120" mass="13267" checksum="4387D6470D97368C" modified="2020-08-12" version="1">MKKVSSCADVAVRKSCKGVETSRQKREQLGRKVLWWDRKERNNKHLPLPSERAHEISLSLQQLVTKGWNAVVKTRLGAAASCCKTREVGDHDGWPPTTNGLRVTTGAKPGGGDFVVFLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X9I6</accession>
    <name>A0A6G0X9I6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_006926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000087">
        <property type="protein sequence ID" value="KAF0736766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X9I6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003637"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0736766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="199" mass="22772" checksum="3E7C99DD9F7F7B9E" modified="2020-08-12" version="1">MSAAYVQKTAMMDPYARVHSIHNMPQQAMDSKQRLQGGPPAPMKREWRGTCRYKSGRCSNERTLKFNGEIHTMCEEHRIRHNNNQRRSDLKRRIKKSPELGNYKPTSMPVSSPLGSPISQTSEPTMSSPRVVHMYSPLSLSNTTPCVKQEPQYTMGPVVDDNWEMDYDIRPATTTMELTDQEAKILYCILGMESEESML</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X9W9</accession>
    <name>A0A6G0X9W9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_007027</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000087">
        <property type="protein sequence ID" value="KAF0736872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X9W9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017810"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07830">
        <property type="entry name" value="STKc_MAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000545">
        <property type="entry name" value="CMGC family protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="4"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="329"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="350"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="367"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0736872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="410" mass="46168" checksum="9F6CBE915C023F41" modified="2020-08-12" version="1">MNRYEILDRVGDGAYGEVLKARSLKTQEVVAIKKLKMLFPTWEECLQLRELKSLKVLRHENIIQLKEVIRDKAELYFVFEYMDTSLFAWMRKNVAKEAHIRAIMSQLFSGLAYMHKHGFFHRDIKPENCLCTSGLDVLKIADLGQAREIRSRPPFSDYVSTRWYRSPELLLRSTTYNSPIDLWACGCIMAELYLGKPLFAGSSEADQMCRICAILGTPTKETWAEGVSMVSQMQFKFPKCASVPLKSIIPNASPAAIQLMVDLLQYDSTRRPTAAQALQYRFFMPQTARSSADAKGTKDSTAACKDDKKMMAMEKEGATARKLCEKAVDEHHDPDAKGGISPRVGSQQPSSSRSKCPTTTTTFTSSGRNFSNRYSKSNASLRRNPEDAADDLDTVVNDAMLQDLLDEVMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XA72</accession>
    <name>A0A6G0XA72_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CHORD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_006832</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000085">
        <property type="protein sequence ID" value="KAF0737022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XA72"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015979"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1130.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007051">
        <property type="entry name" value="CHORD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039790">
        <property type="entry name" value="CHRD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46983:SF3">
        <property type="entry name" value="CHPADIPLOID STATE MAINTENANCE PROTEIN CHPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46983">
        <property type="entry name" value="CYSTEINE AND HISTIDINE-RICH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04968">
        <property type="entry name" value="CHORD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51401">
        <property type="entry name" value="CHORD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CHORD" evidence="4">
        <location>
            <begin position="129"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="CHORD" evidence="4">
        <location>
            <begin position="258"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0737022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="323" mass="36133" checksum="BF720D260268FCC8" modified="2020-08-12" version="1">MGGSESMPVVPEGARLKKVYLHFEEGEEANHLTLKLTIPSKWSGATIDRLKEFFLETYNERKPDNKVNPVEYHLERSEGRILRGDETIHEMIKNRDDIYVKPGPSTFKHRKDFADEERERQQPKDLIQCKNFGCREKFNDANNHATACKHHTQPPTFHDGKKGWQCCMEKLAYDWEEFEKIAPCAVGFHSAVGLAAPKAEPTGFGAPIPILAAPAAPATALKSIDDYNEKNPDAVTAVSAIKAPKPKPAPRADGKAKCVNYGCQKEYVVAENNDTSCPHHAGAPVFHDSGKYWSCCPKVIKYDFDEFLKIPPCVVTAHSDVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XAE1</accession>
    <name>A0A6G0XAE1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nuclear control of ATPase protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_006752</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000085">
        <property type="protein sequence ID" value="KAF0736940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XAE1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005989"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013946">
        <property type="entry name" value="NCA2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28234">
        <property type="entry name" value="NUCLEAR CONTROL OF ATPASE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28234:SF1">
        <property type="entry name" value="NUCLEAR CONTROL OF ATPASE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08637">
        <property type="entry name" value="NCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0736940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="591" mass="67442" checksum="A1BEC3C9742E029E" modified="2020-08-12" version="1">MAPTKVAIVQSKIRQELRGLRDRSDLSEDGHRMAAYFLELMHHLAHHDISLPQVLDAHERMESFLAAQTAFKHIAVFEGAIMELTRAVMLVAMHESLRQLLAFGAFVPEALRYWKRQVKKPLELFLLEIPDKVWDPEGGNVPTEEKIRVLEETRELLLIHIGELKLLMLKWPHAEPKRSPDLMQSAQALLTKVFSTQHLIHPRTAAEVDVDDIVKAQPTGSQRFHLKSALEFLKSLPQARSAYKTALDNALSRCGIPRFLRRRWWHLSIGAFGLAMGTVYLARNRRELTQLAFTMHKGIRDFIVDHMIEPITNIVGEVLLNKKALIQDPMALSDSKESLQRMLADFIHDTNPTMPLEEQKALVANMDMSVVSLQYEKELPKAVRNLITGDIVRMMLIQIQFIKKELMVAMKAIDELMDANQLNMQMMATLPMFVAVGGAYYAVKNTSKLIFRFTSSAIYEDPKTVAAQMRYMLRDIERLLNMQNQSPLDNFSINSQPSSGTLSPLLRATGEAGTTLGVRDMGYLVVVLDQLQTLFERNRGYFDEDEQKRFEEDLNDLVGENLLVSQQLAVIARMHHSHAFLVKSVDSKWFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XAU2</accession>
    <name>A0A6G0XAU2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_006433</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UFD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XAU2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011159"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14319">
        <property type="entry name" value="UBA_NBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01767">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.50">
        <property type="entry name" value="Ubiquitin fusion degradation protein UFD1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004854">
        <property type="entry name" value="Ufd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042299">
        <property type="entry name" value="Ufd1-like_Nn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055417">
        <property type="entry name" value="UFD1_N1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055418">
        <property type="entry name" value="UFD1_N2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555">
        <property type="entry name" value="UBIQUITIN FUSION DEGRADATON PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555:SF13">
        <property type="entry name" value="UBIQUITIN RECOGNITION FACTOR IN ER-ASSOCIATED DEGRADATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03152">
        <property type="entry name" value="UFD1_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24842">
        <property type="entry name" value="UFD1_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBX" evidence="5">
        <location>
            <begin position="291"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="255"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="12"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0737257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="480" mass="54316" checksum="5A4C4163A2F00F9C" modified="2020-08-12" version="1">MDFDLGSRGKKFQKEQEARRQAARQKMERERALQEQANRLRLEMEAETQRRKEEQHRRELEEEERRLEEQRVTGGISYKKTLRAVPILNDGDKVTLPVSALEELNPQNALDLGVFTFELIAGERKTHASVLEFTADEGTIGIPPKVARSLQLIDAVVDVSVRFVRLEKGRSVKLQPLGDGFGDRQVDFKHILERTLHTHTTLTEGDILLVRHGKITFEVLVHNIEPSPQVTILNVDLEVDLLPSEAIEKKKAAEQAAIQAKIDAEKQQLRLEEEKTRRQADAAARLPAEPPQNEGIKLMLRTPEGAQHVRRFHNSDSVSTLYDFITSVTGYTPGSFRATANYPRRVIEESALPLNEAGLVGKQEALFVERVVVERTEIADFEMETLADTPPTVAEVWTAALSEWETKQDEALFTPEVMPVHALEPVLPTSSDGDKWAAQLGELENMGFFNRELNIQILEKYQGRLLRVVNYLSELAVEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XAV0</accession>
    <name>A0A6G0XAV0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_006418</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XAV0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011144"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029982">
        <property type="entry name" value="Kptn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15435">
        <property type="entry name" value="KICSTOR COMPLEX PROTEIN KAPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15435:SF2">
        <property type="entry name" value="KICSTOR COMPLEX PROTEIN KAPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0737241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="449" mass="49392" checksum="5299E6CF47F6E94A" modified="2020-08-12" version="1">MGYGQTWLFRYPAPQNEALAGGEREFSRQSSYYDLEDSSEEEPAANRNRDRDVAAFTMTPISSDRILVTTPWSVCELLYLHNDKQFHLDPVGMSPSKEKYSDLDHAMASAGMPHESSVLACDVLTISPSKSVLVLLYQEPRGRCCLTLQSIPDSSSKTDLSHERSRFEQSSVPLKSVVVNVRDVIGALSFFGVLLFRTDSIIACGYVTDDSTVKTEAAQLSPEQFASFFPHLVDFPYAVVSYHTLTHEGTRLLALGCANGVVRLFSGKAAYDGFATVTETKQFELDGPISSLHLFNVHASQGSLLCDVLVSSSIGYAVVYHHPFNPACTAHVLPDSDYFDSILCCLSADIDMDGSAELLLGTFSNALIAYKHNRATPNAPWSVLTKDRWDFFFFGPVYSIVCQDMNGDGVDEIIIASTDGIHVLEPDCDQVREKLQAVLTLLQPSETSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XAY9</accession>
    <name>A0A6G0XAY9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_006478</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XAY9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010606"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="183"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="89"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="185"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0737307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="350" mass="40456" checksum="AC00D3C76B3742DE" modified="2020-08-12" version="1">MEMDWEDMCRGQQEEISKLKLHITQLESLLHDSRCHEDSASLSDSDAESTPSCDENRTSNPCRDPNFRDASCIQRTHTQASPMNWKNRIKSELEVLERAEKLVARQKRDLRHQIHQLKAEKESWRHEQMTGQSSIILKEMKRILDHNTHTLNQNIRSLRSAESRLQNRMSKIHQMELMVDALENSSSNSSIDNSPSSPQDIFSLFDSDDGQSLASSNDTSSLLDGLNRLHDELQTDAYRLPQELYVYGDEPSAFFHTTMHTPPPMSHETSAHHHRDFRPRESQILRDVQCASIYEKQISKWVYGRRRVQQAAKQHAKWLTSLCDELDAYSKTYAESASVDPTAVFMDDQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XAZ0</accession>
    <name>A0A6G0XAZ0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_006465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XAZ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015820"/>
    <dbReference type="OrthoDB" id="4772757at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052050">
        <property type="entry name" value="SecEffector_AnkRepeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586:SF3">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0737292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="298" mass="33667" checksum="6C9D0DE42672866B" modified="2020-08-12" version="1">MEAVLRNPSLVQVVVEFQRGIYHDIRPVLHAIDPISVAILSHSATLRFGWSHKGVLYHGLMEYLDKFRAVFAPWYATWGHVGIQRLYKCLPRAEFIGIIHVYGALSGQLDLLPVNPLLPTLLFDIAAWHNHLHILEYLCSTCNVLKMDERAMDGAAAHGHLQIVTFLHSHGGRTRYAMNLAAGNGHLDVVRFLHFYRGANERCTKKAMDTAAANGHLEVVQFLHTHRREGCTREALDAAAIHGHIDVVRFLLSHRREGYSPWGLSVARKEGQVETAALLDAFPHLCFVREEEGYIEYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XBL3</accession>
    <name>A0A6G0XBL3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_006701</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XBL3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011108"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07990">
        <property type="entry name" value="LPLAT_LCLAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032098">
        <property type="entry name" value="Acyltransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983:SF16">
        <property type="entry name" value="LYSOCARDIOLIPIN ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16076">
        <property type="entry name" value="Acyltransf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="5">
        <location>
            <begin position="81"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0737546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="365" mass="42274" checksum="33913AEB594E1EA9" modified="2020-08-12" version="1">MTLVLTGLIRGAWTLVWLVLNLLVLLVYEVAACSLRPFSRSLYRRAIGRCFALYVEIMARSFPKCDLIVSGDMPTDTSKPVFIIANHQVDADWWYLSELMRCVGAAGNLKIAMKHTLRSLPLVGWGMEMNDFLFLHRDIKLDRPLIQAHMQSFVQDNFPFWMLLFPEGTTIYSEYVTKSHEFAQQQKRPRLHRVLLPRTTGLKLMLESFKDSPIQPEIYDITMGFPGYSGEVPTYDMFYDRNIDVQLPTMNKLFMGQGPSKVYLHCRRFTMDQVGPDVEQFLDTLWVEKEVMMNEFIEHQCFQSKKDTSRVLRPSTSSKAVGQLWFAGFASFCLFPMLFACYLIGRFLRFIFGGIKIIPKTLRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XCW3</accession>
    <name>A0A6G0XCW3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_005885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0737888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XCW3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006047"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0737888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="214" mass="23328" checksum="BE7BBF549A6D298B" modified="2020-08-12" version="1">MTPQATQAAYSQHNMPPTPQGTVDSRAKLSEFHRKNIHYLVLFLVCSITCLLLVNFLVLPVSSFKEAPPSYSTAACDACGLLNTTKKVYSAQCEGNEPCCPTTLFPTGPVMTACTAVPSCCCPHTVSRRGQDYNLNCPRAKTFPLNATSSECICEYWNAKGDSFGVERAINFLLIMVGFGLVLVISCIWGCVWACQASKMNKAIESEQGNRHVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XDV5</accession>
    <name>A0A6G0XDV5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_005760</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000075">
        <property type="protein sequence ID" value="KAF0738408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XDV5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010966"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43963">
        <property type="entry name" value="CARBONYL REDUCTASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43963:SF6">
        <property type="entry name" value="CHAIN DEHYDROGENASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G15350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0738408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="282" mass="30536" checksum="B4EDEB51A35333EA" modified="2020-08-12" version="1">MAPQVYLVTGANKGIGYEVVRILSERLGDQAIILLGTRSLDNGKAAIAKMQQANPSFNYANVYSLEIDVTKSESIQAAAEFVKATYGTLHALINNAGITAYVEGVDACFNVNVFGVHKTLSAFHSIMVPNQSITIVVASEVGAWTFSTLSPELQAIFANYSAIDIPTLRELANDWKASNEGKSSKQTWPTVGKIFGPYGVSKTMVLALTRKWAQDHADMKTMMVCPGHCATDLNKHSGPRSPVQGGESVVFPIFHSEETKTGGFYRDGVEHGFNVPMPAQFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XE85</accession>
    <name>A0A6G0XE85_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_005655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000073">
        <property type="protein sequence ID" value="KAF0738543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XE85"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0738543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="79" mass="8962" checksum="A8093024FD25331C" modified="2020-08-12" version="1">MCLGTVTIWTREIDRCGFLELGEQSARSPLTAHCTCHNVDWNLVIQINHGHLKCRLASFWLAEFETALACILDGWLGFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XEW6</accession>
    <name>A0A6G0XEW6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_005347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000070">
        <property type="protein sequence ID" value="KAF0738727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XEW6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000302"/>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0738727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="368" mass="41910" checksum="670B73DE2CE0053C" modified="2020-08-12" version="1">MNTRDSVGSYLSSLRNERKVAEKIDEGVPFFVPQLSKVKTSAMCTKAQSHLLFGYERLQHTESYRKQGDKTLYTDEKLLERHNLQHDRQVQAALGRFWDTFGSVRQGKSTIDELEYCDVFVKLFKALVPPNEFSVPEARIIVEKDWARDVGGACDVMAKPMFYKSLFEVADLWTVGIGAEEYTKFLTKLFDRVTMTVFDQEKALWLTKFADLDMIKSSWGEDNQPNLEKSPSPKRAIVKLKKKAHTIASLKLTEEPASLPGLVSPEKPPRRLTRFRPPTERRASVSDAQTADGMIEDLKADGGLSPRASPIKSISPKRQKAPVDGSNQDRIAMPSIYLSPDLDVQKEEELAVKRRIRENTKLTQRFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XFC2</accession>
    <name>A0A6G0XFC2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_005456</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000070">
        <property type="protein sequence ID" value="KAF0738845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XFC2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013228"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052050">
        <property type="entry name" value="SecEffector_AnkRepeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586:SF3">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0738845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="230" mass="26009" checksum="256A84D857293A1D" modified="2020-08-12" version="1">MYRLPHVTRQVLQVPDLLRCMMQFRQGLHIDMFPLRYLAMPLTTNSADLFPSEFANMDLALSPWYFQHGFGRVLRLVECIPRLLPLVLYHAVYHGIVPVVQLLASAYDLRLASAHHHLLDIAAFTGSVDMFTYLLGVVGPAGMSSYASEWAVENGHLVMVQYLNEHRLASFDAQSVLLAAQWDHVELLRYLLDLVKPASVEEAIAIAASQGRKRAVQFLMSRRSSDVEMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XFC8</accession>
    <name>A0A6G0XFC8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cyclin-dependent kinase 2 homolog</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cell division control protein 2 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">cdc2-related kinase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Ae201684_005403</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">May form a complex composed of at least the catalytic subunit CRK2 and a cyclin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="VJMJ01000070">
        <property type="protein sequence ID" value="KAF0738791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XFC8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017555"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010389">
        <property type="term" value="P:regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000375">
        <property type="entry name" value="Cell division related protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF254">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="7"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF0738791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="136" mass="15668" checksum="DD17A2C8F3AAD22D" modified="2020-08-12" version="1">MERYQKIEKNGTIGEGTYGVVYKAKDLKTGNTVALKRIRLEVEDEGIPSTALREISILRELEHPNIVRLLNCLQDSGKLYLVFEFVDRDLKRQMDKTLGTVDPMLIKAYMYQLLKGLAFCHSRGVMHRFEATKFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XFN9</accession>
    <name>A0A6G0XFN9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="3 10">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ae201684_005218</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Helps prevent cellular oxidative stress via its role in NAD biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + nicotinate + ATP + H2O = nicotinate beta-D-ribonucleotide + ADP + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="10">Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the NAPRTase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="3 10"/>
    <dbReference type="EMBL" id="VJMJ01000067">
        <property type="protein sequence ID" value="KAF0739033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XFN9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013380"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034355">
        <property type="term" value="P:NAD+ biosynthetic process via the salvage pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01570">
        <property type="entry name" value="NAPRTase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.140.10:FF:000018">
        <property type="entry name" value="Nicotinate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.140.10">
        <property type="entry name" value="nicotinate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041525">
        <property type="entry name" value="N/Namide_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041619">
        <property type="entry name" value="NAPRTase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040727">
        <property type="entry name" value="NAPRTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006405">
        <property type="entry name" value="Nic_PRibTrfase_pncB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01513">
        <property type="entry name" value="NAPRTase_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098">
        <property type="entry name" value="NICOTINATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098:SF1">
        <property type="entry name" value="NICOTINATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04095">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17956">
        <property type="entry name" value="NAPRTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17767">
        <property type="entry name" value="NAPRTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000484">
        <property type="entry name" value="NAPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54675">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6 10" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nicotinate phosphoribosyltransferase N-terminal" evidence="12">
        <location>
            <begin position="21"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Nicotinate/nicotinamide phosphoribosyltransferase" evidence="11">
        <location>
            <begin position="307"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Nicotinate phosphoribosyltransferase C-terminal" evidence="13">
        <location>
            <begin position="412"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF0739033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="538" mass="59780" checksum="B00115515E12388A" modified="2020-08-12" version="1">MANPTKQSADARPTNSLVTPLLTDLYQITMAYAYWKVGRHEEQAVFDLFFRKNPFHGEFTVFAGLEEVLGFLNSFKFDDSDIAYLQSVLPSTTEPGFFEWLRTLTCEHVKVYSLKEGTIAFPRIPVLRIEGHLGITQLLETGLLNLLNYASLMATNATRFIKAAGKGKILLEFGLRRAQGPDGGISASRYSYMAGFHGTSNVLAGKLFGIPIKGTHAHAFVQAHRDLDDVKVTHIGNHNLKELTLQYRRKLGFLDTNDGELAGFISYAVAFPHGFLALVDTYDTLTSGVPNFLCVALALNELGYKPLGIRLDSGDLAYLSKQARRMFVKTAEDFNVESFKTLTIVASNDINEAVLNSLNEQGHEIDSYGIGTHLVTCQAQPALGMVYKLVQIAGQPRIKLSQESSKVTIPGRKKAFRLIGANGSPILDIMMGCDEADPVSGEKMLCRHPFDEMVRVNVTPSSVVPLHSLVWDGEKEGIVGELPSLEDIRNYVKDQVANMREDIMRPLNATPYKVSVTKALYEFTHTLWEKEFPVRDLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XFZ8</accession>
    <name>A0A6G0XFZ8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tubulin--tyrosine ligase-like protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_005269</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-glutamyl-[protein] + L-glutamate + ATP = gamma-L-glutamyl-L-glutamyl-[protein] + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60144"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:15517"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:143622"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:60145"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000067">
        <property type="protein sequence ID" value="KAF0739089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XFZ8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016007"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070740">
        <property type="term" value="F:tubulin-glutamic acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00053">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241:SF145">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE TTLL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026119912" description="Tubulin--tyrosine ligase-like protein 5" evidence="6">
        <location>
            <begin position="24"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7 8">
        <location>
            <begin position="535"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS01186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0739089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="619" mass="69754" checksum="9982C6E1B0CFB7F4" modified="2020-08-12" version="1">MEGRKVFLLRALLWTIFLMSSTGYGLDATNSKDLRSRKVYLLPRATNSPPIDVLVDILAKEGMNPLLLDGSEAQSWDEAAKTSDYDLLWSIEPVESSQKVDKLDRRHKVNHLPGRDIFSPVKLVERQRSLESQHGRYHYSFVPPSFSIPDQQSAFLKTFEYMRTVPILSGRIASDPHFRRRWRVTNNDGSTFILTKPSDLTAQSIRVTYIVEPLLISRRKFQLGLYVIIASVDPLRVYIYHNPLLRMCSRAYPTVLSETTPREAFAVTDSAWLPPWEMDDLKAFYTEIPSSQSEGTSNLKVLKRYLEHVGIEADKFQQNLHAAVVKIIAGSRSHFVQAETGRPDGMTSGNYFQFSRFDFEVDDEGKPWLVGVDTAPSFAPKQFGSGSITALLSNVARDAIRLIGVSAPKDSLPADSLVQATTSYCDSNCADKLVRWDTSCWRCPGWYAPPIAARLYTAAMEYTRRGRYHLAFPTVRSELAQFVDRGLSPLDHAFHDYLVSFVYDPKGHAAELDPTVLCVNREQCSHNGDCVNGHCQCDQGYEGKTCYIPSDPDRTVLHEELLSRRSIRTSPAATKEDIEIGEAQSDRFYLTVFGIALLCYVGYKLAVRSLIVSSPDKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XG16</accession>
    <name>A0A6G0XG16_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_005147</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000066">
        <property type="protein sequence ID" value="KAF0739226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XG16"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008977"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0739226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="401" mass="46866" checksum="2AC3A70126B7C9F0" modified="2020-08-12" version="1">MPVRRELQTQGMVLCGEDDGDIDLALLEKVDSVLRRRIYLRNIRRVYRRNEKQERLELMDKVVGLEAQLKKLQTPSSKSQTQDTPKSLLSWAIVAETLADEKNAVVAENSSLKHDIAKYKSFGEGMQKWVAAQHTAVRSKRGKNLPRQINMDLMHLWAQLSAENVPRRIRALPSWHNTTLFAEPSLRKMGKQWITQQMFHNTERMYQTFSFPPFESDTPCFYINFEYDDVKYDAVLCRQYGDSRDFDVVCDLYRYRLCDELAVEGPARTLINTIKEQDDLTTLHQMTTRDGEWINLVCSEYREDGRSFFVVQQIIDDELLVHDNSRLRNRMSWIDVRRMPDGSTKKRLICFQSQSFTKADGAVPLEEEVAMWGLYLAAEMKNEAKAMTFKRYLENQLQHAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XH75</accession>
    <name>A0A6G0XH75_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_004784</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000063">
        <property type="protein sequence ID" value="KAF0739608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XH75"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014280"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
        <property type="entry name" value="FYVE_like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="5">
        <location>
            <begin position="294"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0739608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="415" mass="47596" checksum="697C56F0EE54BF1F" modified="2020-08-12" version="1">MHRETNASSVHNLLVDMTTKSLPPNFFHCPPLTLEEKESYKHQGVAAAYEVVKKTKLHGGPIKWKLNSDERDLKIYKGIDSSEPATSSGATAFFATIEVVGTMDEVVDLFRSQTTEQAKEYVRRFGHLMADAVNLYTIVPATPEEPHEMIGISWRAFKPPVEGVVKRRDACVLDVHHTFRVNGKRVWVRCIKSIEIACCPDLEKELGYIRMNHKCTGHVFSESDRPGYLHIDYLLQSDVRGTVGDYAKWIVDLSVKRRLRSAIYIDRFLRENRLSKTPFLNAGELQPLSRTRVCSLCSRWLRILSKKSNCLKCGFVFCHQCIQHWHVKNRGFDAVALVCNRCALGNEEHQKRWLKEATSLVQDSYDHQISIQRTTSRSAKSLPDEPRRSLSNYELLVAQNTQWKSPRVENLMHSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XIT6</accession>
    <name>A0A6G0XIT6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_004263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000053">
        <property type="protein sequence ID" value="KAF0740262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XIT6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003614"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0740262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="864" mass="98103" checksum="A784B30093DC0D0F" modified="2020-08-12" version="1">MGVSSLGHTGLSSSDDSANSECSDHRLQEALPLQAMARRSQRGLHRRKPWRPIKHRLIPPQLGADWSPTDAIRTREARQYESYLGHPVPPPTIRDNTLRVATININKITKTKLYAELSDWFIAHQLDFAILADADIGTQPHQIWCTQTNGSMRPGLVTLGTSRVAILYDYQRIAIHFRLGHRGKLTLLGAYCPDSPHTCRAETQQEWDWLAEHTPPPTPRTLVLLAGDFNTYGTNPMDRSSTAQRSKASVAIGEAYDSWQQLHNWTSTFRQLHPQLPRYTYARAGTAVALDDILIQTNEAHCVTASGIWIGSLHSSDHIGIPIAEIALNLHWTSSSQLKEVCPIRVVNTRKSTPTELAQFTTHTTQLVQTLQLPPLIPPLADTEDDPATISHWLETAMHNLYTILYGSAKSLWGETSQTQRAINRATAIKRSNRCMAQWRYILRLLADQELSIPDIIRLADGIQWPKWVRDPTKLPKEAPHSTGALTLHHWWIHRPTDPHALPGQWRMWLLTGWTHWHQVYKSQRRWRSTAQRLFAQRYRTELFMGKHTRQFLQNALGRPTPPISIRSTMVDQPDGTRTYSENKADVTAALQKLLDNWIPPAERTERPAHLSTLSANDLPQAPRFVREWLLHDMHRPEHIAPGFLHNDQCTWDTYVYTHDMQQTCDRYLRKHVAPGYGGVSQELWIAAPPAIRARERLIINTILRTGCVPPCLGRKQMLYIAKSATAHGIVNHDAGLPPWRPITVQNAFTSRLFMVIRDYITPIIPNEPLQHGFQKDRTVQDAVILTSLLIDRAQQTNSELFLTSKDCLKCFDRVPSWVMEYVYLKLGVPPTPRKLMAHFLGASVKLTSAQPLAGSMVATETLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJ36</accession>
    <name>A0A6G0XJ36_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fungal lipase-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_004312</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000053">
        <property type="protein sequence ID" value="KAF0740313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJ36"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018016"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051218">
        <property type="entry name" value="Sec_MonoDiacylglyc_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856:SF24">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026267479" description="Fungal lipase-type domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="415"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="477"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="509"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="552"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="590"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="634"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="4">
        <location>
            <begin position="856"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="735"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="743"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0740313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1101" mass="122055" checksum="6F9BC28E9E9967B9" modified="2020-08-12" version="1">MRTAVVVLLALVATTALANTCGGNFLAPSSEAGCALGRCTCWSYISQCATNELCEDAMASDGSPLCQGICTLTPLGITLKTLQWLFIGGLPLAILIWHLYQQRRQRNFVFNEGDIEAGDGDGLDGHADEIDPDAVQKTVTKQLSRQATVAYFSYESPKAGAGHQFPPEDEKAVNKNTLDSYIDLGKFSKAQTTNGAFVIKITPQIYLETMHKRVLPLLFLSMLVVLVLTWIFSVYPTRMHSTALQVGDDSCVNSGGQNCSVFSASSALVDGVNLQRVVTFSHPRIATTPDSMTLGFRVENTTFFGRPGIFTLGNYTVRVIAEGAKLPLVESYTNKLIVVCGCVGTSCSSISCQDVPLVGISIKRFDSLLYDVRKRQYTVNVTISPSAKYPTPPDYSLSVQVFHNPYAWSAQLTRGAIGAVSIIVLVHFLYTLSKRNSQEVEGRDRRAYSETPRISSLPPKMSLYERFWGHLSLERQAMALILALMGINFNPVMIFVTRASFGSPSRTYFVFRSILETSMYALSIGALLVILDSYRKDRRGFTNGISWRVMGLRSTIVKAILVFGVLALRLQMTLTSEGNRVNGQGKKVNYTAMLDTILTGSGFLIFFWVAMHVNRVLKAQRYSETRYLQLSFRYLMLIAYSKLAVFILDVITGNGFGALSTTQSAVLPTNSVVGEMAYAVFMYFGVVAFYPPAPLKPGLIPRAYVVRERRQSLHSPRVASPVPELSSPGSIISSPRSFASPKDVVKPTDDDSRTAPLLQPGSRFDAMPVAAQPDNLFCLETACLMLNCSRHTYFRSTLNLKSDTNAEDGQVKFPQSKYVNQAALARDGLREIAHIHDEATDTNVLVLRHVSNRLIFSFRGTSSKENVKTDMNFALQEIKWLTNHGHKYYAHKGFLSAYETVRDQCHAIFESFHSENLPADSYVYCTGHSLGGALATLAAIDFKCTLHKPTILYNFGSPRVGTHSFHHLYKEQVPLAFRLVNEGDLVVGVPQRMSMSCGKHKRLYRHVGTEVVMDGKVNGDFIIRPTFAEKHLIIEGAKKVGRHFLPSYRENLNIIVDGVLRSEQSIGEFHQEDALKEVLNTLDTQTVDTLRSKERQLDDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJ93</accession>
    <name>A0A6G0XJ93_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_004106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000052">
        <property type="protein sequence ID" value="KAF0740368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJ93"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019451"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052649">
        <property type="entry name" value="NCE102-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28165">
        <property type="entry name" value="NON-CLASSICAL EXPORT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28165:SF1">
        <property type="entry name" value="NON-CLASSICAL EXPORT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0740368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="29536" checksum="8B41A035B1E074B3" modified="2020-08-12" version="1">MKPMQKRQRNRTVMAVFRVLHAAIGVAIVATMMESYPTFRLDDGDVYRYAQTYHFCVVVVGYTALQYGAWYFVFVSYMKRMRIDIILERLLDIILLLTHVLCGYFASTKASCPPEATKTTNLRCSGLQATMALCFANAGVFLLVLIYGFVVRLPSHPDSTENLVPRGNYGGNYRMSDQTPAPVDAHVPPVDSDQPGRKSMPMLSPLWDVLSTADKAPTHEDDKTGNLVARGQFGNVKIEDVDKTDRLLPRGNFGSLAQKSALDKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XK96</accession>
    <name>A0A6G0XK96_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_003894</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000045">
        <property type="protein sequence ID" value="KAF0740763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XK96"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011824"/>
    <dbReference type="OrthoDB" id="73372at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0740763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="118" mass="13264" checksum="2F4D4CE366E8F8EB" modified="2020-08-12" version="1">MVEIAPQFQFLTQDLSKSQLAVTAPAKDAMWLRGQPAQVEWDPSNLPVDKVRIVLLQTTSIANQTGAYTMVAECTENNGVFEYRKVPWGLCMDNDYFIRVMSLDGQHFIDGDCFSISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XKS2</accession>
    <name>A0A6G0XKS2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_003590</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000041">
        <property type="protein sequence ID" value="KAF0741018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XKS2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018451"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.10.10:FF:000007">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="8">
        <location>
            <begin position="9"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0741018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="434" mass="49775" checksum="530362626F80E69D" modified="2020-08-12" version="1">MEAEIQQYLDLGLIRPSTSPWASPVLMICKPDGSIRFCIDYRKLNDVTIKDRYPMPRVDDLLDVLGKSKYFSTMDVASGYWNVRMEEKSIEKTAFICKFGLYEWLVMPFGLCNAVPQFERLMEDVLRDQLWKSCLVYLDDVIVFSQDFATHISRLREVLSCLQAAGFKLKMSKCKWGKTSVAFLGHIVTPAGILPNPEKVKSVLKIRPLRNVAEVRAFLGLAGYFRRFIKGFAAISRPLEKLKTAEVFQWTHECDEALNILKRKLVSPPYSPTRIFDKPFFILVDACPVAVGAVLMQRQDNRDRVIAYASQALDATQQKWIHKKDGISEIECYGIVWTTKKFRPYIDRRPFTIYTDHSALVWLFKTGSHSSNGKLARWAVHLQSLDFTVVHRPGSQMGCADGLSRLPTDASLELIQTSDSYRYDGQHEEWVLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XM70</accession>
    <name>A0A6G0XM70_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isochorismatase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_003243</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000036">
        <property type="protein sequence ID" value="KAF0741562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XM70"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021873"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF1">
        <property type="entry name" value="ISOCHORISMATASE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="9"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0741562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="162" mass="17632" checksum="5F2F034F851896E2" modified="2020-08-12" version="1">MVALPKASSALILIDVQEGFHQPPYSSLARSTPEFEANATALLAAFRQAELPVIHVHHHSLLDDSPFHPTHNPTGIEPQVFVRPAPGEPVVVKNVNSSFIGTNLESHLRDNKWDTLVVVGLTTSHCVSTTVRMAGNLGFRVFLPVMVLRCLSGQRRQAVSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XN79</accession>
    <name>A0A6G0XN79_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_003365</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000036">
        <property type="protein sequence ID" value="KAF0741697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XN79"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001400"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00014">
        <property type="entry name" value="CH_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000016">
        <property type="entry name" value="TBC1 domain family member 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="2">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="218"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="595"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="683"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="740"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="839"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="683"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="814"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="848"/>
            <end position="860"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0741697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="893" mass="99760" checksum="549E4F8C7278089A" modified="2020-08-12" version="1">MVLSKKIEGSFFQALQDGSILCSLINQLYRSLGMKHITVPIETRDGTALSSRRQNTHTFLDACRTLGVADDALFRPNDLLKGSNPQKVYACILALQVVAIRMARQRTPDERASMGSNIPSSVESEDLKVDRLHSPHAAIIDWGDMSMFVKDATSSQAAWRTLLNLFEAQQAQVFPSMPTVHEGGAYNDYQGSGESAHALWRTEERVRSLVHEETACQYLTPELHGKLWMLLSGASTDMRVNKGHFAQIVSSSSVNVESIRQIDADVPRTVPEFDPDWSPEMQAKLRRVLVAYAAHNPSLGYCQGLNYVVARLLQFIESEEECFWLLTRMVAMLPEDYYTTMLGAAVDQHVFAELVSLQSPDILRHIERLGGFGSEMSLACTEWFCTLFGSPCRKEITMRVWDLLFMNGNEELFRMALALLQVEYPNIMSCHSYGDVLACLNQIGRDEHLDPKLLLHIAHDQAIVTTTRIEDLRAYYRLELASGIALSKDENESGSRTSELTTKKRKHPTSNRKIKSRTMSRHLSLEKIDVKVSDAAEAKYFPDSSSPPELLEDYWRDSDAGPGLWTVAKFKLITSPSDGAIDDVSRPRQFSDTSYRHTFTGEKPSSLRVSRSKSTAEGLRHRASYSHNPPTDHKPNNFLKKIEEWTHRTLKKKPNGGGLNFEFFGGALTGQGTFFFNNSSTTQISENAPVSTPSDPVPSETSDMDDSIAESPADLPEPSPPMQITIANRIIGSRSTPSLVSLEMSQGESSHDEGEDDVDRPRSSSTTFRPPRHHPTPDGRKPQSSMLSLDDVSPPDMRRHTSMPARGAGRPAKLNQSNLDTNNRWLRERAQVVSYLQRKASDVSSLTSDRDSLGSDDGTRRSHRAITRTNSFSFLGSLSVDLERSLLLEDKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XNB8</accession>
    <name>A0A6G0XNB8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_003076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000034">
        <property type="protein sequence ID" value="KAF0741886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XNB8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012585"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="1">
        <location>
            <begin position="47"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0741886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="188" mass="22096" checksum="050C8EA6733F54F8" modified="2020-08-12" version="1">MLDERRSPRGEQDEQSQQKEERAILQCTRQFYLEIEKEEWKFDALYDLYDLMTVRQVVVYCNSSQGVEWVAGRMRAKDHTVSAVHDEMEEIERDAAIRDFRCGISELFVTACTFSNALLFSNMRVVVNYDLPTQVESYIDRFGPHRQFGRGDIAVNFVLASEMSMLRQIEQFYHTEIPELLSNINDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XNL9</accession>
    <name>A0A6G0XNL9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_002939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000032">
        <property type="protein sequence ID" value="KAF0742002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XNL9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014018"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF57">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="1">
        <location>
            <begin position="223"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0742002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="364" mass="41869" checksum="D584A6F04BB81C7B" modified="2020-08-12" version="1">MTVLSVPVPHQPTDAIKRRPRPTIAQKLWAVSVLEKWSIHDAVRITGYSSTSLNKWKREKSLLEGFARSKTRKKNIGLTGQKAIIPDAYGMAVYIRDIRRQEMALTAAHMISYLRVNHNEWLHEYMSTRKSPYSSLLRLLQRFAHRNGFSRQRLCRQKRTQEDLEETRLSFGRDFHEKYGDVPADCVYNTAETGIYYDMSPKTIWAVKEEGAYVANAARHSMRMTALLTIRTDGKKLPIVFVIRGVPGGAIKSNEFDSYPPGHYYVMQSKAWMDGRVWRTFLRDVLMLDIENPSILIVDNFESHVSEESERIINDELGCQLCLLPPNSTSYCQPLDVSIMGPFKQHLRDLWVLATDSAKTAKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XP01</accession>
    <name>A0A6G0XP01_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_002857</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000030">
        <property type="protein sequence ID" value="KAF0742190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XP01"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012982"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="43"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0742190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="135" mass="15417" checksum="02944C0817A244C0" modified="2020-08-12" version="1">MSGGWKEVAKQIQSLIDKHREFDKQALRLSGVEEDESGTSMILDDLVQLVDDAKIENENDKKEKKLEEKKAEAAGQIIRDEAMKTCKKRKSDTNDETRGNPNLALIELMMAEYMSDMEFRQKKMDIKALVGRKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XPY2</accession>
    <name>A0A6G0XPY2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_002557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000027">
        <property type="protein sequence ID" value="KAF0742459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XPY2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009362"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF251">
        <property type="entry name" value="EG:BACR7C10.4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0742459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="339" mass="36994" checksum="5D2156E717E8F9E2" modified="2020-08-12" version="1">MIHATEKLGTAWRAAVARGAELLVKALPKACALPIDEIVGIAARINENIYSAEAKTPHSPIATVGLFPLAGLINHSCSPNCTWSSGATPGTMVVKATEFIPHGDEVCLYYIDVNQPRAARQTQLQLTKHFTCACDRCIAPWSPTSVDTIIDGVCCAACHELYQDDSGVCSTCGASLLNASTATELKSKAAATLKQAQAQYERKQYTAVQDLLCRLDDPSNGLELHPSHWVLMSAARLLADCFFKTRDYKASYKYRCRVVESLRATTSFYSQAMASAYIQLAELLAVSMKHSVWSDGDEKTAKLAELKTAFTTGLDIRRVCYVESHPLVQQVRAQVEALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XQ03</accession>
    <name>A0A6G0XQ03_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_002480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000026">
        <property type="protein sequence ID" value="KAF0742579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XQ03"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016131"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0742579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="31995" checksum="0C63FEB1D20CEB10" modified="2020-08-12" version="1">MPNRDVTKAVVYAPSFQLPQVVLELELAKRAAAAKKVLQKQAYRRNQSKMNQRRYRAEYKSTTEYLTTAVTKLTTEVARLEGRLETLRFTVPVELRTFDAECNLICEYYRLFHIGLPKNEADPKRNLLCDFLSKSMTQDVAFMDEFGQDKLLRQWMMYSTSFLGFEMVLLSMEVVSFSPNIVVHSDSTLNLRLSRSSVAMLFPHLLHNEPLVQRMIGRILILPVQQNFVFNSDFAVVKYDTYVNLAVALANLLGSLTDAATAMSGVLIKETGEIVAEVSGDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XQ53</accession>
    <name>A0A6G0XQ53_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_002522</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000027">
        <property type="protein sequence ID" value="KAF0742420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XQ53"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002386"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46347">
        <property type="entry name" value="RING/FYVE/PHD ZINC FINGER SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46347:SF1">
        <property type="entry name" value="RING_FYVE_PHD ZINC FINGER SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="7">
        <location>
            <begin position="26"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="34"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0742420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="189" mass="21115" checksum="AF026AE88E5548A6" modified="2020-08-12" version="1">MNESCESPLIAMSVDNMGEDSEVVVAVAVDTPSCYICLDSMCGLEGDDLELIAPCACQTFVHRRCLDDWHKSSNSKAHCQTCKSAFEFEEMPWTKRVKSSLSFQIGWRLLLLGAVFCLVVDDGARLLLAFVWEAFLYVVAVPIFAMLTLYLLQAMLGVICIILTWGIQSAAPPRVKNLRRRQDDKDAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XRC8</accession>
    <name>A0A6G0XRC8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_002276</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000023">
        <property type="protein sequence ID" value="KAF0742880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XRC8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020185"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="3">
        <location>
            <begin position="108"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0742880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="26396" checksum="855D955282F952E2" modified="2020-08-12" version="1">MDEILPSTTKEDPILLVRGEDNLYKCLKCGYKLEEYDAMRTHYKRSHGLKVEHKRKKTEEEKNDNARLRKVRFNERKSAARALEALSKHRPLFSFADAQLRGTYGADNPIVISMESSIPTAGYGVFVAVDLCEGDVVTSYDGDIEYAMPADPTYVLSIDIGKKSAWIDGLSTRQLSKGLGSFVNHEDRTKKVFKNCEYLQHGKKMLIRVTKTIKSGSELFTVYGPGYRLKSDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XTP4</accession>
    <name>A0A6G0XTP4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_001624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XTP4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000793"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="162"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="250"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="460"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="566"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0743984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="875" mass="98799" checksum="4018DD7772C98586" modified="2020-08-12" version="1">MDPFEIHVDDEAVELRSRLASANTEILTLRDQVDRRTQLLDDLRSAYMRDVVVMKDRLWKHGITSDADLAALPTADLKPFLPLFSPASHFLDVRPCSACGGGVHLVRRDDDVLAQALVDAQLAKQRLTASQSVQASLEVSLSTALADAATMQRLVFKEKKLNASLVNEKEKLQSQLASIQSRSWHIGVLEASVQDLQATISRVEEEKAAVTRWLDQTRLDLVDADQRHAVAIAAAAQSMEELRRESQLHLQSVQDELVQAHTTMEALRAEIQALHESKDALETRLRAEHLGELNALTTSWRREMDGTALERNVAGMVLADVQGRWSQTSARLLAAHDRINAMTSEKRALLRARDAADARKTELAQELAASSQRVERIQREMATQVESTARTLQLKLLWLWMKAQARETTWSAWCQFLKAAWRLVKVEKTERVGQLVGGTYVQLSTDGATTLAHLEKHEAIQHLERSLVQADERRRDLQDHVRGLQAKLERVNEALTQRTREYTIASRALAAAECTKIQLQSAVDTMKEAADDEKEARCRAEMAQHDAWTRFLSIFQALEQCFSDDMAVMHAKLQDLQAKAALLEEEKADAKTLLVQCQERLAATVELLENKKFECMAFQNDLADVADEMVSLERKLAGEHRRAAMYEEMVANMTKVIHDQQTTIESLEIRLDRRNERQASIDLDWMLRNTAATTIQMAWRHARACRLHRYKRGIQQRQVEHVITSTATAQRNSAQGLQFVRATTELARFLSQLGVDTSFLCPSSTAFDKKLAGVKGNTAAACLQNAWRMYAKRKIVASRLALSGLQARHRRLVKSLHALDLTRRHYQQLRALGVKFEPAKVLPPKRTPPVRPKSAIPGLLKYRLQHPIKSTNNQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XTU6</accession>
    <name>A0A6G0XTU6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_001509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XTU6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004258"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14809">
        <property type="entry name" value="bZIP_AUREO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="347"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0743866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="450" mass="50508" checksum="4EC880496E9F52A9" modified="2020-08-12" version="1">MASMDNQFFDDVMDSDDLTLIDGAIPFIANMSHLNIHQQPPMHPNSALPPMHRKGPAPMGGGMPMGQFMQNQLRQGQAGGMDVDMMNQNNSAQANSLFQAYASQFGAKPNTSQMTLDNQHDDNSIEAYAALMGVKLESPRSMQKQQNAQYSQNDVSRAQMNAQYFESLIQQQSMPPHNGHHNMTSMTLPAGIGSGFQMNRQVPVMDNASRAPRVDSTQFESNHTTADALIDAVRVKSEKPLHFTHGSVVGSQTLSPEMLLAMTQNNRQNSADVTSHSFGSNTWNASDIDFEKESLISKADKSRERNRDHSRKSRLRKKAFVECLKTEVKQLQLFKDLCEQNPDLIAMVSLDQERKVTFLTASYNRVLGYHEKKLMHDEISFFDLVHPDDVAKVRSELNRIAKYQDMWGVSYNVKHSKGTYWKGDMSARMCDQGIVITTRVQRPAEASNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XU98</accession>
    <name>A0A6G0XU98_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH-ubiquinone reductase complex 1 MLRQ subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_001272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000010">
        <property type="protein sequence ID" value="KAF0744130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XU98"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001445"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010530">
        <property type="entry name" value="B12D"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06522">
        <property type="entry name" value="B12D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0744130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="94" mass="10362" checksum="30BFE110181098CA" modified="2020-08-12" version="1">MVAQRLARSTARTWFSDPATYPIMGIVVTATSVASFAGFRYLTKCPDVAVDKEKRLNFLDRHDTKSGSEFRSHRNAVALAVPGPITEQTEGFKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XV79</accession>
    <name>A0A6G0XV79_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PWWP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_001050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009461"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05162">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWWP" evidence="2">
        <location>
            <begin position="215"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="PWWP" evidence="2">
        <location>
            <begin position="349"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="PWWP" evidence="2">
        <location>
            <begin position="1230"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="domain" description="PWWP" evidence="2">
        <location>
            <begin position="1377"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="667"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="811"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1136"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1497"/>
            <end position="1534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1572"/>
            <end position="1622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1730"/>
            <end position="1771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="667"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="763"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="811"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="828"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1154"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1205"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1511"/>
            <end position="1525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1599"/>
            <end position="1614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1757"/>
            <end position="1771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0744581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1940" mass="218828" checksum="FE35DB9250961090" modified="2020-08-12" version="1">MFDNRPDLREEFAAAMAEANECFTGKDGNPKLPFLEPWDLNKKLQAPPKPVVPYNSLGWGYKEGYPWLPIFVLDPQTVRPNLRQLGDKHADDLRQATLRPNSYRLVYVFGLHEIVLRPNNMVKPWHGPDHRTFVKGSPKNLKNEILFVTLAKALQEVKDYVNADESTRLLPLLDIGDIGPAAATSNHLYYQCGRMHHDDVKMPLSMMETSLLDSVGCLAWFKPPDQPWWPVYVCDPDALRDNLHILGGGHLVQLLRVKNSPRELRLIYFLGRYIFGLQKAEELKQWNCPEKQDRLRAQPMPGSSKDEIEEFTNAMSEAMEYSRTGVLPYIASHDLDLRAEAPSQPIIPLNSLAWALRDGYPWMPVYVCDPSVLKSNMRNLGNKHASILEIAKQNTSSHRIVYHFGAHDFVLHKTKGKLRMWNGSDHTHLLNRMPRSLFAHQTSRDWRVVNTVMYAKFETAMKEVEAFIKAKPSQRLLPKMVPSDLEISTLPLLLDNDEGESDERMSIDNGMDAMNDNEETREDVNADADFDCIVWAMLQINVWRPAYICNPFKLKTDLTLLGNKHGPMVNEARNEPKLKRILYFFGSHNFGLRRFPQMIKPWKCQEHASFEAEMRQATPDATDVLEEIEEFCAAAPSNRILPCFAEEDEYDFSTVYHRLRTEEINEAVETKKSNKDMRSINNSSRTHDYHDGKRKAMKDKDMSTHSGKGKGKSTVPPVGSRATKKEASYSDVTHSSNERKRTSSDMTDSIPKSPQPKRLRKLPRPEQTKEKQNLARAPLTFQSVQSRGQIYIPSKDGQTTRKSHSVVTTAPIVNSDMSTSRNSHQHNSDSLRSPSTQFGRQIPSSPVISKESKPLQPSQLTEKNSIYQVSINEIPYDSVAWARMNSSTPWWPVYICDPNRLKPSLQLLGNRHETALATVKKYPTDLRLVYLFGSCTFDICKQNVVPWNCQEQELFVQGHPSFTMSSNRSYRDLRKAVRDAMNYFGKDAYTRLLPQMVESDIVSRTISQSIPQNSIVWAKSGEALWLPVFLCDPSLLNPSRHDLGRINERAIEIAKENPEHYRIVYYFGSRNFGILKSEGIVKWWNCPEHEQFTQGRPVPNVDDQKKAEHIDKVLAAVRDTKAFIATDRYDFPYPYESSSEDTRLPHWQNKLPQPEIPPKNQPPPAAKSQSEAKTPKPVNVAIPRVMVTSTNTTGGRHVKQRGRPSKSSPTHVETPFTPTKSSTWTSNACLAWAKISGYPWWPSYVCEPSKLRNDLVLLGNGHQAYLEKAKQNPTVCKVVYYFGSHNFGLHHIDSSKPTGSKMNSLKPWNCPDHKTLIGGFPFTMNATYPEVFEEFKSAIKEVEAFENEDDSMRLLPYMVPTDMDLSLKPPPPTSIPLGDMVWALSSGYPWMPAYVCDPHKLRGQLFHLGSSHKKFLEKARANPDECWIVYYFGAHTFGLHKTRGTIKPWRCEEYDNFVDGYAETLLVDEDAWAEFKSAIQEAKAFASADPSTRILPGMVLSDMDSPLPHPTNCSEPIDLTSSPESTPKKDPLSLEGVDISLDSLVSTSKEGGKAKQAPGKLRIPVRYAFGRRIDSSSSSGGHPSDEDTETDDEAKSSVAKLSNTARPSVLSGQRDTLVPDDFKYNQSQRQILQELKENESGDIDIQEIVPHSSRDRDDSVAVKEEPIVYSSYSGADITETTGVFSEAISTSPARASPENVNIQSLQSETIEIEEDEASVIIMKSAYSQLDKQNGNKSEDAPTSEVKNDGVESTSENSGKDKEDTSKIFDSRTVDEDSSEVIELKSAYLQVNEPSNIKDNEGVMIESSYQLLGKQSPTAQPVPKIFAETHATSILDKPGKDSAVTSVAWVELNSDCWWPVYIDTSSKQEVTDVEVVHFVTQKREILPAKSLKAWNCDDHDAFLAKVAMQGNEDSASLAQAIQEAKDFLESSDATKPFSGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XVM8</accession>
    <name>A0A6G0XVM8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_001196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XVM8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004872"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0744741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="504" mass="56815" checksum="7FBEBB8800FA59CB" modified="2020-08-12" version="1">MTGSLLEDLKQLEATTRHFVDATAAIQQKAGELLNQASEAVQKAGVSTSTTTEDNLVPFITWVESVFQTKNTSGLHALAKAFLQRDSQSVDKFLDAAENITIFSNFNVAFDSKQNYFATSPNRAKTTKKLDPVKPVKRHVNEPSNIAKSPPPKKSKPSIDTIVKETPPPDEMAKKSTVVEKKPAARRNLKDEVPTESSNVEPLPSPSESGRRTSSRSAAMTANYLRRERDSQLRGLNKLEEEQEAQDLTLAVAKSTKTSELKPESLEKPASEETVEFEYDVALQAKPWLKWTRHFQSFLPGDSKRRKTFNEDLKAFFETHGQTMWERFFWTGVGTPKDQKARLHAAHSDFGKFVYRLHLMEGDNVFKFLMRAPHPAWPTFLTHPVALNKMTPSEAVSYLKSESDSRWPKSPKPWKYDPLLILSILAAKNDDILKKHSIPLDWASDLLTRLRANPSYDFDACPYVDVTMFGEEPPTHLQGDVVATASGRVWDWEQQKVVSRVGLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XVV7</accession>
    <name>A0A6G0XVV7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ae201684_000716</name>
        <name evidence="13" type="ORF">Ae201684_000718</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000008">
        <property type="protein sequence ID" value="KAF0744811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VJMJ01000007">
        <property type="protein sequence ID" value="KAF0744856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019319"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000289">
        <property type="entry name" value="ABC transporter G family member 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000528">
        <property type="entry name" value="ABC transporter G family member 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013581">
        <property type="entry name" value="PDR_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08370">
        <property type="entry name" value="PDR_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="435"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="465"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="510"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="547"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="579"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="665"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1083"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1113"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1156"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1195"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1225"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1327"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="71"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="748"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="703"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="703"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="728"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0744811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF0744856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1352" mass="151373" checksum="203BF9803C0327A6" modified="2020-08-12" version="1">MSAPAITADGFLAEGSDKFHEMLANNLETASGKAMPQVEIRFKDFSLAADVAVANKDGAEELPTLWNYAVKSVMSLTKNKRIVHKDIVHPVSGVFRPATMTLLLGQPSSGKSSLMQMLAGRFALEKNIQLGGTITYNGTPREEVASRVPQFVSYMNQRDFHYPTLSVKETLEFGHLSCGGVVPQRVLDSLKHGTPEQNAEATKIITALYEVYPQVILKQLGLVICKDTIVGNAMLRGVSGGERKRVTIGEMEFGMKQVSLMDEISTGLDSAATFDIVKSQRSMAKCLKKTIVIALLQPSPEVFELFDDVMIMNEGYVIYHGPREEALPYFESFGFRCPPGRDTADFLLDVGTHQQDMYAIPGRTVPRYPAEYAALFQQSAIYRRMMDYVDGPVHPLLLHDATHHMQEIPEFQNDFKTSMRNLVSRQLKVTLRNTAFVRARMFMVVVMGLIYSTTFYQVDPQQAQVVYGVIFLALLFLALGQVAMIPTFLEARAIFYKQRSAQFFRTIEFVLAQTATQFPFAVGEAIVFGSIMYWISGFASEVGAFLIYELILLMTNVLFASWFFFVAVVSPNLHVAKPIALVSVMFFVMYAGFIIIRSDIPDYLIWIYWINPLSWCMRALAINQYTASDYQVCVYDGVKYCDDPAVGPTMGNTLLELFDMETKKYWIWLCLAYVAAMYVLFVFLAFLSLEYCRYTSHHEGVHVDDHEKEEAEAKEKEAAYNEMPPTPMTSQTSQSYTNGSQSFVPVTLAFKDLHYFVPNPTKGEPELELLKGVSGYALPGTVTALMGSSGAGKTTLMDVIAGRKTGGKIVGDILLNGYKATDLAIRRCTGYCEQMDIHSESATFREALTFSAMLRQSSDIPTATKMVHVDHCIDLLELNNIENSIIRGSSVEQMKRLTIGVELAAAPSVLFLDEPTSGLDARSAKIIMTGIRKIASTGRTVVCTIHQPSSEVFFMFDNLLLLKRGGQTVFFGELGVKSTKLIDYFTRIPGTPPIHEGANPATWMLEVIGAGVDARANTTDYAEVFKTSNEARRLTAELEQHCQPRADLPEMVFKTKRAATNAIQCAYLIQRFMRMYWRTPSYNLIRIILSILLAVLFGLTYCSVDYNTYHGTVGGLGMVFMTTLFVGIISFNSVLPLASEERASYYRERASQTYNALWYWVGSTLAEVPYVFLTTYAFALIFYPFVGFKGGFGEILFYGLNMSLHVLLNVYMGQFMAYAMPRVDVATAMGILMNSIFFNFMGFNPPASQIPHGYKWLYHITPFKYSLAVLTAQVFSKCKDGTEMACEQLQEVPAAILHEFGVKNLTIKEFTEGAFNMKDDDAVRNTFVVIGCIVLFRILALFALRYINHQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XW13</accession>
    <name>A0A6G0XW13_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">methionine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_001102</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>tRNA(Met) + L-methionine + ATP = L-methionyl-tRNA(Met) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="1"/>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XW13"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001612"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.220.10:FF:000001">
        <property type="entry name" value="methionine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023457">
        <property type="entry name" value="Met-tRNA_synth_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326">
        <property type="entry name" value="METHIONYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="9">
        <location>
            <begin position="28"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0744638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="542" mass="61643" checksum="EB030C138A03AFBC" modified="2020-08-12" version="1">MLRRILRRSVVLQQPRLGRTSHFATTTTITTPIFYVNASPHLGHLHSSVMADALTRWFQFRQEPTLFTTGTDEHGLKVQQAAQKAGKSTPQFCDEVAASFQAMCVQGDVKYDRFVRTTEAEHAVAVSAIWKTLVENDFIYLGEHEAYYCISDETFLTEMQIEKREDGQMVSKESGHPVELVKEENYKFRLSQMQEPLLEWLDENPDVVQPPSRYNEVRAAVARGLRDVSVSRLREKIEWAIPVPNDPAHSIYVWLDALTNYLTCCKYPNDMAHFKTCWPAAYHIVGKDILKFHAIYWPGFLLAAKLPLPEKIVAHAHWTVNGVKMSKSLGNFGIDAVRYFLLREGVLTDDGDFNEDMLKEHVNNELADTLGNLVIRATTLAFLPEGKVPEGANYAQDELELIHLMNETVQQVQAHYERPDFSLVTKSIMNLLYEVNRHFSKNEPWVVAKKLKALPADAPETEDTRASRQLVANTLYLSIEAVRLSALLLLPIVPTTSSGILNYLNVPEAERTLEYSRFGQSNYGPVSNQKSKTKFVPFRKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XWY6</accession>
    <name>A0A6G0XWY6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glucokinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_000282</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XWY6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018121"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24008">
        <property type="entry name" value="ASKHA_NBD_GLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003836">
        <property type="entry name" value="Glucokinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00749">
        <property type="entry name" value="glk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47363">
        <property type="entry name" value="GLUCOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47363:SF1">
        <property type="entry name" value="GLUCOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02685">
        <property type="entry name" value="Glucokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0745251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="413" mass="44769" checksum="92E3558373087A24" modified="2020-08-12" version="1">MASDNQDYDLIVSGDCGGTNTRLTLWRVPHNSVHLKGKIAPGQVVYNKKFLNESHSSFVEVCHLFLKEAGVDEPPVCCVLACAGPVLNNSVVFTNIAFGWSINGENLQRELGIETVKLINDFVAMGYGLLTLREHEYLVLNDVPREEGAPIATVGAGTGLGECFLTPSGDTYECYPTEGGHGDYAPTTDIEVEIYDKLRNKFGPDKRLSTERMVSGNGLASIYEHLAEKFPEKVNKEIHTEFLGSESLRGAVVGKNASHDELCGQAMEIFVKGYGREAGNAALKYLPRGGFYITGGMAPKNLDFFTKKPWFLDALFDKGRVSPALKTVPIYLVLTEDLGERGAHYYSYQLLSKSRGHAPSVAAPVSQVVSPPSSLKKHSASSFSPYAEAIKYFAVAASALAGVIVGFRLAKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XYE6</accession>
    <name>A0A6G0XYE6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Preprotein translocase subunit Sec66</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_000225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000001">
        <property type="protein sequence ID" value="KAF0745778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XYE6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000428"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031207">
        <property type="term" value="C:Sec62/Sec63 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018624">
        <property type="entry name" value="Sec66"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28229">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28229:SF1">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09802">
        <property type="entry name" value="Sec66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026017943" description="Preprotein translocase subunit Sec66" evidence="2">
        <location>
            <begin position="27"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0745778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="22765" checksum="AD5667C7E2826790" modified="2020-08-12" version="1">MVSAVEWVALAVLLFSLFLVYSAVSAMRPKKGAEGDDMLEEMINGFDFTLPPQIEEYRALKEKAPENLTEEDLKTLCSALFRRAVADIPLIRRIQTEAQGMHRLKTNDLIKDGSYMSFKLAEEMIGEEIKEVREEAQALQPEENWGESIFAQAVQFINHMSEQEELAEQKKRQSEADAKKQASKQAQMAAQLNADLRKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W343</accession>
    <name>A0A6G0W343_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WRKY19-like zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_019257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000584">
        <property type="protein sequence ID" value="KAF0720936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W343"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010308"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056866">
        <property type="entry name" value="Znf_WRKY19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827:SF1">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24906">
        <property type="entry name" value="Zf_WRKY19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WRKY19-like zinc finger" evidence="1">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0720936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="227" mass="24280" checksum="D36F5AC27E355A08" modified="2020-08-12" version="1" fragment="single">MNLTHSTASNMHGMLECADWKCIQEDGDFDIKIIDDALDFLHTSLPSFQAYMTLNASPTSVEEMLFTELLVMEPLQIKGRKVKELTLKVEPSTEGASYSCAIQGCQVKMNHPRGCCKKHGGKKLCGMDKCGNGAQKGGLCIRHGGGHRCRVDGCIKAAQTLGKCKSHGGGVRCSVPGCNKTSQGHKKCRVHGGGKRCCVVGCVKGVQKGGFCAAHSPEKHAVCPIHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W543</accession>
    <name>A0A6G0W543_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_018653</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000345">
        <property type="protein sequence ID" value="KAF0722174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W543"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0722174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="168" mass="19239" checksum="FD3E9AA0FF2B1908" modified="2020-08-12" version="1">MSQLHVAVWKEGCQVDWKNKYSVHSGDDTVENGCQLWKPDKLSGVGGDKLPVVMVAARKSCTSRCKIEGNGRIQRKSRHSMEGFHGLEAVDQGQFRHTQYLEMQEARLDFQLSRRTSDETIKMEIIWLVLPSTVVMGQTTCGCNYSMKYGSYVKQTHSSVRFKCSRWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W690</accession>
    <name>A0A6G0W690_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_018308</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000330">
        <property type="protein sequence ID" value="KAF0722575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W690"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002285"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38899">
        <property type="entry name" value="DOMAIN OOKINETE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38899:SF2">
        <property type="entry name" value="FCP1 HOMOLOGY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0722575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="237" mass="26711" checksum="18D1A276F27A140F" modified="2020-08-12" version="1">MAPNGFPSEDMFKGDSEVLNNMNDTVIFLDWDDTLLASTWVGKLGLRPKYVNEKPIIPDDVKMQLEELEECVIALLETAIKYGRVVIITAAETGWVELSASLFMPRCIPIITQHIKVVSARSTYEELYPASPKKWKIEAFLHEVYNHPNEYSTTPKHIISIGDGPTEREALINLKMAGCDNSFHAKSLKLITYPNAVELKMEVRLLLDNLHTLCTHEEDMDLQISKEVFQTAATSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W6F9</accession>
    <name>A0A6G0W6F9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_018491</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000337">
        <property type="protein sequence ID" value="KAF0722364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W6F9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014520"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF214">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="434"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0722364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="698" mass="75129" checksum="345F88969752C591" modified="2020-08-12" version="1">MPTFTCLADPEQGHGYGAFYSDSQGHLGCKAYIVTRFPSKWEDNCVFYKSASECEAAKNSLLPLTTNHAFYDLNQYTQGMKNLLNTIINATAKPTPAPSTTAKTSTLSPPPATPSSKAPSTSTPPASSSSAPKTPQPSSSNAPPAVSPTPSSPASTSSDNPTPSPSVVSPQTTTAGSTSVPSSTSSTTIAPSTTTERPTESPSANSTTDSPSYIDVSIPPSSQASTEWNCIAQGPVYTPVRINAESGQFECLATDTSDSDSDCYHLEDYSKCTIWLQEQETCLASNSCLQGVHVKIVQGVTATTTSSAYSTPSTTVGTTLDVPGSPGNSSSAPLVTIVLGVVCAALAIAAILGFVLWRRRQRQDEQFTPKNSPMLLMTEKGIVLKQMADLEDATAVVTLRASPMPSRSTISSQGASQPLDMGELSLWRLDNSKLTKTKVLSVGTTGTVSLGLYKGHQAVAIKQLLPHQSDEIAQGFIDEIKRMTKLESPYILAMVGCCWVRPREIELVTEYMENGDLRQFLDKTAPIHYSWKDKRSCIANLTQGLVYLHSMDIIHRDLKSRNVLLDAKLHAKLADFGVCREITMETMTCGLGSFRWTAPEILQGKRSSQAADIYALGMIVWELDSHQPPYATQQKALHITDVVVMSKITRGELSPEFTPSCPRHVVSFVHQCIAQDPDMRPTALDLASLLLEQESVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W6G6</accession>
    <name>A0A6G0W6G6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RxLR effector protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_018706</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000349">
        <property type="protein sequence ID" value="KAF0722069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W6G6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018222"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026252917" description="RxLR effector protein" evidence="2">
        <location>
            <begin position="28"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0722069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="24316" checksum="FEF97E02FA325AAC" modified="2020-08-12" version="1">MLRKLVFAVVTTAAAVLSASPVSTSNASQVNTTNNIIPAVVTPYGRELFGKLLHDLKIEHVPGQPISTIEYNEAVDGVEDIIRGRWKFDKKYDEQVKRAVRNLMARMTPAEMEQLFNDVAFDLITTLFAETFPETNITFNASSSVNASAPRRRAALVAVDSLVIVSAFAACVVAIAMIASVAIRGKKEEKASSLSITAEVILAEIEDAEKMCQVDLAADKDAVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W6Z7</accession>
    <name>A0A6G0W6Z7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RxLR effector protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_017978</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000318">
        <property type="protein sequence ID" value="KAF0723014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W6Z7"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026357552" description="RxLR effector protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0723014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="114" mass="12606" checksum="8AB11A27C55A8D30" modified="2020-08-12" version="1">MRIFLSLLVAATAVLAFHQEQVNEPTVFEAPRALSADGGRQILGRGGLNGRRVRGRRGRGRRGRGRRGLVSVEEVQDEAEETTRELTAAGRRRGGRRGGRRGRHGGRRGRGRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W8R4</accession>
    <name>A0A6G0W8R4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_017577</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000303">
        <property type="protein sequence ID" value="KAF0723544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W8R4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002917"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13999">
        <property type="entry name" value="STKc_MAP3K-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF214">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="272"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="227"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0723544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="541" mass="58591" checksum="A0EA7B48D19055F5" modified="2020-08-12" version="1">MDTCSIILSSVSSVSAYYPSCTLAKTIGSGKVNVATLKTSDCLDLTCQTLLSSMGTYELALGSSVKCTLTDTSTGKSLTLSNLTTVCDGITASSSGGGSSLTIPPSYTLPTSAPYTFSPSSIMNPTSAPATISPFIAQYFPTEEKKSSNTTLIVVCICVAVVVIAIAVIFVVRHRKRNKTPPPPLSAQPYVSNQPYEAVVEDGRYSQHATTVSSHPSHSHHARTKGSSRGSTKGSTKGSTKGTESTQASSTGYSGELDMCDLELHRVARNDVHLIKVIAQGAYGEVWLGEHLGSTIAVKRLLPTKAKLADVQKFIWEIHLLSKIECPNVVQFLGVAWTKPSDMLLLTEYMDGGDLRQVLETNQSKNKFTWTHKLKCALSIAEGLVFLHTMDPKIVHRDLKSRNVLLDSSFNAKITDFGIAREIDDSTLTAGIGTYRWIAPEVLQDGHYSESADIFSLGVILSELDTEIIPYSDLRNNAGKPFTDTAIMAKVMSGELKPSFTPDCPRWYVDFALECLALDPELRPPAMKAAYQIRSHIQGFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W8Y7</accession>
    <name>A0A6G0W8Y7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_018291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000329">
        <property type="protein sequence ID" value="KAF0722625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W8Y7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010850"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032727">
        <property type="entry name" value="CLAMP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28457:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 119"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28457">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14769">
        <property type="entry name" value="CLAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0722625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="223" mass="25257" checksum="DC5D4D6CBB883D75" modified="2020-08-12" version="1">MGKKDEAKEVVVESPVPPPVEEPKDPPGWELVWSVLSKEQVEALLNADQTPTATIASLCSFLHVEHYDDNPRSRAWIDFFFYHVLFAKEEARFSAEKLGLFIAIMHQVFDHGTTPPLPTLVDNYGLLKQLLKKHSVDLAAENSVAIFTLQDVQAIVSYLITTFYQHFRVYQRAFTVHPDFIRVVKSVAVETPMPPLPLASTKELQVEPVLEPPRLEAEQPLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WA89</accession>
    <name>A0A6G0WA89_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_017110</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000280">
        <property type="protein sequence ID" value="KAF0724141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008949"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011641"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054465">
        <property type="entry name" value="Integrase_p58-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22938">
        <property type="entry name" value="Integrase_p58_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="4">
        <location>
            <begin position="550"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="325"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0724141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="852" mass="97439" checksum="7B7D1A7CADC2E771" modified="2020-08-12" version="1">MEDVLRDQLWKSCLVYLDDVIVFSQDFVTHISRLREVLSCLQAAGFKLKMSKCKWGKTSVAFLGHIVTPAGILPNPEKVKSVLKIRPLRNVAEVRAFLGLAGYFRRFIKGFAAISRPLEKLKTAEVFQWTHECGEALNILKRKLVSPPILAYPDFDKPFFILVDACPXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXNGKLARWAVHLQSLDFTVVHRPGSQMGCADGLSRLPTEASLESIQTSDSYRYDGQHEEWVLQDTVFMAATIASNRNNPVDPTERNPGFSTPTRIESNPITFDPDSQNPAVPPIPDPGTDLPSPEGGSYDTQSDRQVTSIPVDTLPKYTAVTYRLPSKLLREEQAKDLFIQAVKGYIEEKAIPTDPEVLQILIRTGKHFTMDKKILYRRTILRSPLRNPTVTKVPVIPMSMILTVLELCHDSSLSGHFGVTRTIDRVKRIGYWKGWRDDVIDYCCKCLRCGAAKGTRPWKNGLMQRMPVYKLRGPFSFLVVDALGPFPLTPQGNRYVLIFVDYFTRWPEEFAVPDLKTSTFIRILVDEVVCRYGVPDHLLSDRGTNFVSDLAKNMYKILGIDKLASAPMHPQGQGLVERFNSTIATMMKMYVNSLQTDWDTYLPRLLWTYRSAYHETLGDSPFFCLFGRDPVQPLDQVFLNQDPLWKSDELPQWRRQQGALFRVTRQLVENQLIEGQNKSARSRSDQSRVEFEPADSVWVYQNFRKTNDPDDKRIKKLAFDWHGPYRIFKKQGDNTYRIYLPSHPDRIVLINVDRLKKFQGYWSRPYDDDIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WAJ2</accession>
    <name>A0A6G0WAJ2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dynein assembly factor 1, axonemal homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_016923</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000272">
        <property type="protein sequence ID" value="KAF0724381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WAJ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020735"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050576">
        <property type="entry name" value="Cilia_flagella_integrity"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973:SF9">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="337"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="418"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="337"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="425"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="477"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0724381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="486" mass="55485" checksum="DFA21675A0F52B42" modified="2020-08-12" version="1">MFSSNNDEIDFLERMKKRDREKLKSKQKGHLPVMDRETLVQLCIDNDGYETPELNDNLFAHFKGFQKIEGLELFYNLKALWLESNGLTKIENLDCLSELRCLYLSKNLLERVENLHMLSALTTLDLSENRIKTIEGLGQLVHLSSLNVSKNEIELVSDIEALKNYKSLTNVDLSHNKLADPDILHVFAAMANLKALRLTGNDVVSKTKYFRKTYITTLPGLGYLDRPIFDMERRTAAAWKEGGAGAEEKARQDFIQHEHNERRRTLQEFRDWQNEVRAKKLEELAKRREAGEKTVSYFDVRLSPRLMAQARADSLEEKKMVAGDGITQLGRTFWAEEDARKEQNDTKDNNEEINVGSRNVVAEPAQKSSEDDKKPQAEPNTLSIDEVPVALDDILLEEETPPPMIQLEDDKTKVSTSAINSNAAPERDTWESLQRKAAEAPVIHRPPTLPSIYDTRDGDDNDENGQVKPVTRDGLWQSFTNMTQLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WCI9</accession>
    <name>A0A6G0WCI9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_016400</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000253">
        <property type="protein sequence ID" value="KAF0725002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WCI9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021355"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000004">
        <property type="entry name" value="pre-mRNA-splicing factor CWC22 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF3">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MI" evidence="7">
        <location>
            <begin position="510"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="462"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="710"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="39"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="82"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="725"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0725002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="755" mass="86190" checksum="BCE43B815DA0E1AF" modified="2020-08-12" version="1">MAPAKSPRSPSSDSRSSSPRRRSPSPRRTSRRYSPSPRRSPRRRSPSPRRSPRRHSPSPRRSPRRRTPSPRRSPRRRSPSPRQRDEKFSRDGPRGRDDSRDRRNDRRDDRSRSPKRLRTRGRSNDREERKRDDSHKEDKRKQTPVETASSSKKDDNKENEPQEQPAAPVKNKTANILTQDVRSGRTGGVYIPPFKLAQMRREIEDKTSQEYQRTTWDALRKSINGHINKVNVSNIANIIPELFQENLVRGRGLLVRSIMKAQLASPGFTHIYAALVAVINTKLPENGELLLKRVVHRFRRSFKRGDKVVAIALVRFIAHLVNQQVVHELLALEVLWLLIKNPTDDSVEVAVNFTKEVGAMLTEVCPEGLRAIFERFRGILHEGEIDKRVQYTIEGLFAIRKGGFADYPSVHKELDLVDSNDQITHELGLEDEVDVEDKLDVFRFDPDFAKNEKMWAEIKKELLGESDSDDDEDDESSSDDEDSDKEEDKPADASNATVQIHDMSEQDLVNLRRTIYLTIMSSVSHEECAHKLLRLNIRPGQEPEICSMILDCCAQERTYLRYYGLLGQRFCLVQREYQSAFDDSFANQYATIHRLETNKLRNVAKFFAHLLFSDALPWTVFEYIRLNEEETTSSSRIFIKILCQELSEHLGVQKLKERFMDEYMSLTFAGLFPKDNPRNTRFAINFFTSIGLGGLTVDLREHLKNAPKMLMSAAPDDSDSDSSDSDSSSSSSSSSSSTGSSSSGSSSDSSSSDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WD06</accession>
    <name>A0A6G0WD06_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">Ae201684_016282</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000248">
        <property type="protein sequence ID" value="KAF0725197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014752"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014753"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0229">DNA integration</keyword>
    <keyword evidence="16" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="14" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="15" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="19">
        <location>
            <begin position="596"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF0725197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1502" mass="167540" checksum="C9B9677AB7CF8AC0" modified="2020-08-12" version="1">MHSIPSCRIESTGDHPVATANDGLEIGATGTAPAETVHGPTADRIHDPAALSTCNDKERRLLTDISMIERVKAVGAVKWLPTKNFVGNNFHYWLKAIRNHLKAARLWEIVTGTEIRPSAPVESAHWDHLNRLAVTVLMDSIRDDLLLGVTGEESAAVIWETICNKYLEVKWGTSASLLGKLTNLKMASGSDVNEHLTVFREYSEKLNEMGEGLKTSQLTALLLGSLPDSWNTFKTSFWILKSAPSYDELEANIRTEAARRGSELAAKRKEDKKALQGNAAEAHAAQLAQQQLDLFRRLDSIEANLASGRGHPSKRLQGAKAPNPHVNETCEYCKRKGHKADKCFMKRRHQNDLDQANKRAHIVESNLSERFDDDEAMDMKTEGSEDWKWSGSAWANEAWASRASTRGLSELKYEWVVDSGATHHMCYVMEMFDQMEASTKSKANTVGLPNGGHLAVEGVGSVILTVKCDLTDQRVKIKLNGVLYMPKFNRNLIFVCKSAKAGLKFNFETTEDHLVVMSNSQSITHIRADESLEKAEANAMMAHPTFDLWHKRLGHLNPVAMKRLLDKGVVRGFKVVQSDLDGWICDACELGKKTRRVKLPSSAALVNRCNAKVHSDLTGPIETPALDGSRYVCLFVDSHSSFITCYCLTKKSEFNELLVQHRAVIQNKHNLPLSELHSDNGGEFVNKQSKDFCAKEGILHSTSVPYTSQQNGKVEVRFRDVFAKARSMLIDGNLPKQLWDHAVQCAVYCLNRCPSGTRKTTAFELWHGYQPNLSAMRVFGSLCYVHIPSKVNVSTDAGRAKTKRQKLDYTAVRGIFLGYADDRHAYKVLDCTTGQLLVSIHVTFDELDSVASQELKRKELLKLAQINDLTFDFYSRQASQDVDFLFNGETTKDTLDDEEINASESFVQQFSIPENDLGEINLAAPHGSHLVFHNLDFSPSSSKLLKLSRLQAQSEELVRAEVEMAKAEAYSAAIPASSIPIPRNYEKAMTSKEWEHWKAAIEMELASIKSNGTWKYVKPPQDRKTLKTTWVFRVKEKCDGSIERFKARLVVKGFLQVKGLDYDEVFAPVMRLESLRTLLAIGNALDLPIDQMDIDTAFLNGTLEEEIYLDLPEGLQMKDVIKDANWEGASELTSSPSQVSCLLIKALYGLKQAPREWHKVLTTFLGGVGFEKTNVESCIYVRRLKSQLAIVAIYVDDLVVVAENDNVMAEVKTATKNRFASKDMGPINYILGIRVERDREKRIMHISQPLNAKNMLMRFDLDQARPATIPLDKVLDGSDCPLDGHVQTEAERLNHANFRQGIGSLMYLMLGTRPDLAYAVQALSRYLNNPGKSHIGKMKQVMRYVAGTIDYGLVYHGTDLNLRGYTDSDYAANPDTRRSVSGYCTYIGDCLVSWSSQCQRIVAQSTTEAEYIALAQAAKEVLFMRTLNCELGNPIATGIILHADNQPAIATATNPVHRVAVSLNPVNTPFTSRVSIVHTGSTSALRRQKSEVDSTLVICKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WF42</accession>
    <name>A0A6G0WF42_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NADPH--hemoprotein reductase</fullName>
            <ecNumber evidence="8">1.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_015745</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.4" evidence="8"/>
    <dbReference type="EMBL" id="VJMJ01000231">
        <property type="protein sequence ID" value="KAF0725894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WF42"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012332"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF17">
        <property type="entry name" value="NADPH--CYTOCHROME P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="9">
        <location>
            <begin position="31"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0725894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="555" mass="61521" checksum="66781DA236F86147" modified="2020-08-12" version="1">MTFPAPSWWMRFSCCCLGREPKVASSPTRSFKVFYGSQTGTAQRFATSLAQQLGLDSAAPLESFKANAAPPQFLFIVCASYGSGGPPDNAQRFYDLLDRAKKTWPALKGVQFAVFGCGNSLYMETFNGMAKFVDSKLAQLGARRFLDIVLGDASSDNLNTQYKEWETTILQRLGRIEAPALPQKSPIQQVATVDEAIFQLESIRSLSKTAVHIELMLPPSIASYNSAGTIVLYPRNAREVIQALARRLNYDLSQTAEPPHVTIDEALTNSVDLGVISQILLAGLAPFATDASQASALHHLGTTEGLPEFTQMKEKLTLLGVLETFPSIENIPWKSLVPLLSPTKPRQYTIASSSRVFPRSIHCCITVPDQIVIEERKGTMGTFLKSLVEAENKSTCGISLRGKLQPSSFQVPTDLKAPLIMIAAGSGIAPMRWLWQDRQAQARENRVQVGPTWLFYGCRDDRNWLYKEEIAQLTEINLTTIVAFSQAPDHPKKYVQDVLQEKLASLVEYLDVANVYVCGKTNLARSVSEILRGGRTQLWWDNLVATRRFNQEVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WGF5</accession>
    <name>A0A6G0WGF5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cellulose 1,4-beta-cellobiosidase (non-reducing end)</fullName>
            <ecNumber evidence="3">3.2.1.91</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ae201684_015513</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains.</text>
            <dbReference type="EC" id="3.2.1.91"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 7 (cellulase C) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.91" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000223">
        <property type="protein sequence ID" value="KAF0726181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WGF5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018094"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016162">
        <property type="term" value="F:cellulose 1,4-beta-cellobiosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07999">
        <property type="entry name" value="GH7_CBH_EG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.100.10:FF:000001">
        <property type="entry name" value="Glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.100.10">
        <property type="entry name" value="Glycoside hydrolase, family 7, domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001722">
        <property type="entry name" value="Glyco_hydro_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037019">
        <property type="entry name" value="Glyco_hydro_7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753">
        <property type="entry name" value="1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753:SF2">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00840">
        <property type="entry name" value="Glyco_hydro_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00734">
        <property type="entry name" value="GLHYDRLASE7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="CBM1" evidence="13">
        <location>
            <begin position="536"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="478"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="478"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="488"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF0726181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="574" mass="60409" checksum="5078CB54C9EB1C9D" modified="2020-08-12" version="1">MEVVFALRSIEDPIFGFTPSTTSPTMKAAATIAYLATALVAFSDAQQVGTSKPEVHPSLPSQTCTASGCTTENTKIVLDANWRWTHNVDGYNNCYTGNKWDTTLCPDPATCAKNCALDGADYTGTYGISASGNTVSIALKTGANVGSRIYLLEDDKSYKLFKLLNKEFTFDVDASQLPCGLNGALYFVQMDQDGGMSKFPTNKAGAAYGTGYCDAQCPHDIKFINGEANVKNWTPSKGDPNGGSGQYGSCCAEMDIWESNSFGQAYTSHPCSTTEPTRCASPTECGDDATNNRYTGICDKDGCDFNPYRFNNHTFYGPGSSYTLDSSKPVTVVTQFITDDNTDTGNLVEIKRFYVQNGKVIDNSNINWSGIDAINSLTDKVCDQSKVVFGDTNDHSKKGGLKAMGAALKKGVVLTMSLWVDYAANCLWLDSTYPVDKSPSVPGVGRGPCPTTSGVPADVLSQSGGATVKYGNIRVGSLGSTTSVKPNPSSSVPTSAPSSSAPSTSAPTTRPTSAPSTSAPTTRPTSAPSTSVPSSGAVGAWGQCGGGSYSGPTSCVSGYTCKAYSEWYSQCIPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WGV4</accession>
    <name>A0A6G0WGV4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_015385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000218">
        <property type="protein sequence ID" value="KAF0726363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WGV4"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026005996" description="Secreted protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0726363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="95" mass="10249" checksum="B2413DE0F505750C" modified="2020-08-12" version="1">MAISSRCDALWHLVRLLLCCGCSRRPPILPTTTGDSSNCPTCPGVPAALYTRPSLSSPIRPGDRRPFLSSQISVNRARSKRTTGLIISPNLTLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WH11</accession>
    <name>A0A6G0WH11_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_015336</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000216">
        <property type="protein sequence ID" value="KAF0726448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WH11"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0726448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="136" mass="15048" checksum="306F3A1332C3270B" modified="2020-08-12" version="1">MAMAGDNALGRAPGEEAATDCWQPIKRSTFLNANLLRHCCAVQSLANVISTVAESSEFRAILLCTSSEKPENRIVHHAVRFVIRTCRADTIHSGKLPPQVSMQSQGSELDLVRWKHHLNALKNNATPQSQHFLDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJ18</accession>
    <name>A0A6G0WJ18_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tyrosine aminotransferase</fullName>
            <ecNumber evidence="5">2.6.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">L-tyrosine:2-oxoglutarate aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Ae201684_014754</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:15093"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:36242"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="EC" id="2.6.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13 14">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 2/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.5" evidence="5"/>
    <dbReference type="EMBL" id="VJMJ01000200">
        <property type="protein sequence ID" value="KAF0727226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJ18"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000138"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00338"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004838">
        <property type="term" value="F:L-tyrosine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005958">
        <property type="entry name" value="TyrNic_aminoTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005957">
        <property type="entry name" value="Tyrosine_aminoTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01264">
        <property type="entry name" value="tyr_amTase_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01265">
        <property type="entry name" value="tyr_nico_aTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45744">
        <property type="entry name" value="TYROSINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45744:SF2">
        <property type="entry name" value="TYROSINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000517">
        <property type="entry name" value="Tyr_transaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="10 13" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="15">
        <location>
            <begin position="39"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="14">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR000517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000517-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF0727226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="416" mass="45528" checksum="A08D77DC78873014" modified="2020-08-12" version="1">MPTEAQWHTMFPSDLANNTTNPIRKIVDHIKMPKDPIKPLILLSLGDPTVFGNLACPDVLTDAIVRNVKSHKHNGYAHAAGTEAARAAIAARYGTPTSPLTKDDVIIASGGSGALDIAITGMCNPGDNILIPKPAFSLYKSIADAHRIQARYYDLFPEKNWEADTEQMASLIDNRTQAILINNPSNPCGSVFSKSHLEAILRVAETHRVPIIADEIYGDMAFGDAKFFPIASLTSTVPVVSVSGLAKQFCVPGWRVGWIAVHDRNDVLKDIRAAYFKFATVILGANSLIQSAIPDILTPEAGSAEEQSLAKFKTEYYSTLEANAQFTLDTLRQIPGLRVVVPQGAMYVMCGIDTARLDIKDDLDFTQKLLGEEAVLVLPGQCFQIPNFFRVVFSAPQDKLAEAYDRIKNFCARHTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJ38</accession>
    <name>A0A6G0WJ38_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chitosanase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_014665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000199">
        <property type="protein sequence ID" value="KAF0727248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJ38"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004200"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016977">
        <property type="term" value="F:chitosanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.141.10">
        <property type="entry name" value="Chitosanase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.386.10">
        <property type="entry name" value="Chitosanase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000400">
        <property type="entry name" value="Glyco_hydro_46"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023099">
        <property type="entry name" value="Glyco_hydro_46_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01374">
        <property type="entry name" value="Glyco_hydro_46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="Lysozyme-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60000">
        <property type="entry name" value="CHITOSANASE_46_80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026333261" description="Chitosanase" evidence="2">
        <location>
            <begin position="18"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="377"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0727248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="442" mass="46749" checksum="35B8B5AEEC3AA8D8" modified="2020-08-12" version="1">MKVIVTLVLAQTFLATAQTCSGGYSGTPGDSSWLKFINCGKKTSPSSNTQFASQCSSSSQPNNWPNAGPYSFPSDLDTGYGPKLSQDQVYAILSLVWTAENGGDDFKGIIPWWKAYSYIQNIGDDRGYTTNIVGFCTGTGDDVLFLKNLKKIEPCNPLVQYIPDIQALSTKGSDALTGLEGFAMKVLNQGGGPTGSGPINPNYIKATWATLSDENSDGGGYWGMAMKTSRKYNLALPISKGQLYDIALNNGNVDDVIKKVTVRPPTAGESGGAQEVAWLAALQKVWIKIISDPTNQLDGGQNDRGVMWQHLLDPKSTAKNSQGQVGATNTVPLLQLELPMTVHIYGATITIQSAGGSKPTPSTSPVVRPTPSPSQKPTPSSSTKPTPSPSKSPTKAPTTKPSPAGGGCGDCSNCYYAPTQACFVGWTQAQCDSVAAYTWCGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJC9</accession>
    <name>A0A6G0WJC9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_014602</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000198">
        <property type="protein sequence ID" value="KAF0727342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJC9"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0727342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="97" mass="11329" checksum="BC831D0DAF4EBF9B" modified="2020-08-12" version="1">MLFNFKARSLKRLLETGMKQKCEDWKRSSKMNMATPEEKFPQEDAAIASANYPSALELYTKAIKTPHMLFGNRSARQNHPKQMLMIKPFQLIQQGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJK6</accession>
    <name>A0A6G0WJK6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_014654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000198">
        <property type="protein sequence ID" value="KAF0727397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJK6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016104"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="430"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0727397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="638" mass="71958" checksum="CA52610802907B89" modified="2020-08-12" version="1">MNIRNRTRQLLEFQAVARTTQRMVYLEPSREDPTEYRIVQDHCVTGGYQSKDYIYNESYALPLVQRILLGMNSSINLTAVPLTHALIVDCDYDGRYYQDTTMFKIFLVDIALQSISSIALQTMNAMRETTKLETQVGATVVSQAQLDRFRLGPDDPPDAPWLFGLTYDGATDYRTLVSLYFPYEDDTPFLETHHDGILPSNEYAWRIRATNESMSVAGYSGYYQGSKESQTNILRYLMDMTGNPIRDFVVNYYVSLSYTKDAWTWIQGLVILTVGIALNIAVMTTVFKRKMYLPDVFPTIKRHIHVRAVLLVLAFITDGFWTICEWALTAGERPGDLLVLFLVWTDVVASALGVGVWPTIPVVAFVVCHAHSDALVLALTSADIEKTVANYFTDAYVQNIVLYSTTGMNQWTRHALDSGDPPPWLVAREFAWFLAPCIGITCSLLLYKLILLAVSKFRGKRDRLQTNDSDNVSVAVSEMSGDARRAVRLLTLPPPSFLFSKDAFQMSRTIVWCAGWLLLDDMLVVYADDLLRVFARVLLGVDFGHIYCCAVEIQESRHVLIPKLIPLPVSELTWRSLVHISIETLWVKKVRDGDEQQGQSMADMSMKLKSKSGRTMANVAVKPRRSNANSVAGLQTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJM4</accession>
    <name>A0A6G0WJM4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_014532</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000197">
        <property type="protein sequence ID" value="KAF0727419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJM4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010492"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050576">
        <property type="entry name" value="Cilia_flagella_integrity"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973:SF35">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="458"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0727419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="488" mass="53672" checksum="9A109DAB92525F71" modified="2020-08-12" version="1">MTLDTQAAQSVPKTATDALELLLLSTMAITVHNGAKAKEKRATVAKDDAPVDYRECQRQLAEFDLRFGSSSEAARKNERKHNDKFLRSTLGNTYSDVDACALDWCSGLDDIVQETWERAKLFKMLHNLRLTKLAIHSIDETFSKSCCNLERLDVSENSLTALKELPPSLQELDAYMNQLDKVGIHDCPALVHLGLGLNKLAQIPSVSHPERLLSLDLSFNVIEDLSATLTALRGLVNIKHLFLQGNPVVLSRGYRHGLLAAIPSLTVLDDIEINDKEKEAVQQTPLSTQNFAELTMDVDVVGLFKTDVVMYEATIELSPDLLNLSTTDAAGHPNVHFECSRVPLPISCTLRDSFQFRAFVLRVFEVIKSSSDADTESRKRDLRCSVNVDLSGLLTPQSLEQRMGELTVAQSFNIKVALPPIPPTVPPPKGAPPLAEPTYQEHDCQVHVKLVLNPFDTANGANQTAELPKVPSSSSTSNLKSPSSKTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJZ5</accession>
    <name>A0A6G0WJZ5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_014383</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000193">
        <property type="protein sequence ID" value="KAF0727555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJZ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009722"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019900">
        <property type="term" value="F:kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045198">
        <property type="entry name" value="CNBL1-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23056">
        <property type="entry name" value="CALCINEURIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23056:SF110">
        <property type="entry name" value="CALMODULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="82"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="144"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0727555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="239" mass="26113" checksum="0B8324684F8DAEDE" modified="2020-08-12" version="1">MGAGASVDANNGAPALTPRVAATIEAKTHLSADELQLLGQRFQRYQVDGTGGVAQISTDTASLPTGSIDRVKFQQAMGLPEKESLYADRLFQVIDTNHDGRISFDEFAQSVALLSTKAPMADKTKRKTHHSWQHSIMSFHVVSFQILDMDGDGLLSKDEVTSMLHTSLAENKIELTKDQIHHIVERTWTDIGLAANDSLSFDKYTEVVARSEGMLSHLTINLSYLLNACGVQTTLAQPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WK07</accession>
    <name>A0A6G0WK07_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb/SANT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_014426</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000193">
        <property type="protein sequence ID" value="KAF0727599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WK07"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021632"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024752">
        <property type="entry name" value="Myb/SANT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47072">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47072:SF4">
        <property type="entry name" value="MYB_SANT-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12776">
        <property type="entry name" value="Myb_DNA-bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like" evidence="2">
        <location>
            <begin position="4"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0727599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="293" mass="33234" checksum="62B3001DF10EB702" modified="2020-08-12" version="1">MTSWTHELDLIWINEMIHQGDVLGKRTNNGFKKEAWKAALDKLNRRDDCNFTMLQLKTRNTSLKEKFGLIHRMANSSGMGFERATSKLICISTSWDAFLEGKSEEMKNSLWWLACTRKSRSLFCQPNSWPDNWSSEEEKDDGGEQVDDCNDDDDAAPSESNEMTQQDTDLASSSGGTKRRRQSSGRSPPKRIRQSAATVLASVLKDQGENLSRDFECFADKILGKNNEAHESKTEVAIDVLQSDLDHVLDESEMLGAIQVISSEDKAKIFLKLRGRIREVWLREQIRSSHGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WLB6</accession>
    <name>A0A6G0WLB6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_013917</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000181">
        <property type="protein sequence ID" value="KAF0728087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WLB6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003204"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014513"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="360"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="560"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="920"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="920"/>
            <end position="929"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0728087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="939" mass="107145" checksum="AA22B69B82A38F6E" modified="2020-08-12" version="1">MDKCCVCGEDEGPNLRQCGMCISKFHHMCIIEEGKKRGWAEAEEGREVCIQCQASDIRVPEVVPPPARKRGRPKGSKNKAKAQDTEDASTPVKRGRPSNSQLRSGDEASEATAIFTPDHKSIRSETMYRCVSFKPLREVQIHKNDKKLLDFYADCQDFMLSGVVTEVRYVVGSENDPDSDTPGKKSKATTKTMVALYKITWNHTRFQREEPWISARLFYKGVEQFATLKANQRMNAGRSYLQISSFVPDEELHEMTEWNMKFLTDSSFDEENKDDEETKNDMQPVDDGSDDEWSEYVERGWKKHGNYDTTEEIEGLEDVEWICGGHCAGPTHLYEHEDNKDDTPVDESRISDEFKDLFKDPVKGFLAFMPLEFWKTVTLRTNAKALALQVAHSKGYVGGREFKKSFELVEVMKFIGLLIMMSVVQGGEYSLYWSKPSMLFLMPPTENFGRIMAIDRFKQLRACITFNDVVEPADPLWRIRPLINLLKASFKNFVVAGREISVDEACIPCRSSYARALIVYNPKKPLGKYHFRIYTAACATTWYVFAFKIHSKAAGNFDAEADDDADDDGEPAPDDDTAKPRDEVKPSALRQHVIDITKQWEGSHRVINLDNWYSSVQLCLTLLKMGLYCRGTVRSNRAHNPRFGMFDKKQIKSVMRGSSLVSVATSLGIIAVSWLDGTVVNMLSTADATTKSFVHRRIGSQTIQQESSHSSVCTTRASFKQWYKKLGFALIDIAITNLYVLYTICEPVNRRDSHLHFQTKLANQMLFETDWTLFSETQVPMEYSSVPTTQSAKALKKAAAKDKAAAVQRDASLRQPPTLTNTCRATDKQAEVSYGQRMRRYCVVCYYERSKELIKTQWCDVHQVYLCTKAYLQSEQAVPAHLCPYPEWSCWDKFHSFYQPKGLFKKDGKMDRGNELYKMKKQSEKEHKTSSAKKTLVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WLI6</accession>
    <name>A0A6G0WLI6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_013977</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000181">
        <property type="protein sequence ID" value="KAF0728151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WLI6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018816"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005629">
        <property type="entry name" value="Skn1/Kre6/Sbg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361:SF1">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03935">
        <property type="entry name" value="SKN1_KRE6_Sbg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026304059" description="GH16 domain-containing protein" evidence="5">
        <location>
            <begin position="16"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0728151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="435" mass="48160" checksum="0EA91EE75F221C10" modified="2020-08-12" version="1">MQLLWVFLLVQAVQSIDYDYENYPAQSGVGIWIDVDTPADVKTKVSSRGDKWELVMSDEFEIDGRTFEPGKDHVWTALDIPDGVNAAVEYYNLTNVYTENGKLINRVDEGPVNISYFNQWLEKPAYEYGQMHYSGGMMQSWNKFCLQGGLIEVSVKLPGAINNVSDGVHKSVTMNPNALGVQWKDGQQIKLTPRDTIKDIGYYPTWPGVWHMGNLGHPGYCMNPYQGRGAPEVDILEGGGAAISTSIQVAPGMPSEYRRMPPQKPGNIYCVYGKGCATPGANIPDAPSSAFAYRGHKNWYQGMRYAANDRCPSVPADMQSYEQVAAVRANPALLTSNVYDKTQMSAARDVNADLGLIDGKGTKHWGINYNGTCFPIANGYIGAYLCDPDSKNPRCAAPRREGVIPTKQMDSFEYQMCNRAQKGRGRNLSARELVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WM42</accession>
    <name>A0A6G0WM42_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_013756</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000178">
        <property type="protein sequence ID" value="KAF0728392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WM42"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002377"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044845">
        <property type="entry name" value="HPAT/SRGT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31485">
        <property type="entry name" value="PEPTIDYL SERINE ALPHA-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31485:SF7">
        <property type="entry name" value="PEPTIDYL SERINE ALPHA-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0728392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="504" mass="57076" checksum="D45FA2505DEE4A2D" modified="2020-08-12" version="1">MADRAAAPVPPLQPLSRQPMWILVAIIAVMGLGFIALNVESDFVVRSSSVAHHQDAKNTTVQIVYVDKPIEKIVEKAAVDIQKVYQSDAYDNTYVHIVYSTSCDQPNRHFLSAALQISASKVGQRGPITEIVSGCNEEGVVRVSSEPTFYYDFHRHFTPSYNRHPEPGVKDDYTPYNKPYSLKNFLHTAKEPAGARGNMPIALIDVDFFFFQPLRVNLGRNVTKYYHGKIQDRDILDTVEDGYALAGDWTAYYGGGWFDTANKDKKDIICKGKPCMNVTQEEGREFYAGSGPPYILTKNDWLRMIDDYGKFVVEGRKLNTDWMIEMYGYGLAAGNHKIKHTLLSNLGPTWPKVEKNSWNFLEESTPNPCDDTTLDIVMPKDPPVMIHYCQKYGYLDAQDQGWHFYKYHIPYDILKCDAMILQLPPPTQWTDIPALNLTGSALRGKRHEVWAECTLGKIMNQAFLTTKERLCPLGYNTHQGIPMNEPHKRDTALPGGVPKVKTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WMI6</accession>
    <name>A0A6G0WMI6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_013519</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000175">
        <property type="protein sequence ID" value="KAF0728554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WMI6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000444"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="454"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="490"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="627"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="757"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="146"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="776"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="813"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="851"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="864"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="896"/>
            <end position="905"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0728554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="905" mass="100797" checksum="370E6823112CD977" modified="2020-08-12" version="1">MGKRRKGRPKGLQHGGRRPSSPSHGAAPSREVDDDIEPPPKMNFPSPSKEPSPSKATVKELPPKEGSMPPLSSQPEGVKEKKDNRVNEATQQPPQDDKSPAKPSTSAQAPSVDVKPSISIPSEENTAVARREVETKQDEAVEMEETAGKVEEDVKGALEEKKDEEREQEEAKESELPPSEAKDEATTSTRESDKTTTDLDDRVDAMAKERPATETSDDSKEEKEDTAKHDDSAEVAAPPRYQVDLTQFNLSTEKAHRITQHVLFGWIKASTPIRARFSQALLSPSVPLVVFCDAFSPLRDVEIAAFQVAYASPSDDATARCPQGEVYLDGQRIHDFAMAKVFAVELVEFQLRKAIRDRAAKKTRGRCDVFRCVRDLVGDHVDPITPETLLQIAVGKLGLACPAWAAQCIFCRILAAPRAQMCPPKHFVHSLDQFVCNVHFDESVSVEGVFRELARTRDMEQSFRAMDVDGSGALSIAECTAFLHGRGIDFSKAVLEEFLQRFDRDGDGSLNLDEFLACCRPKQHFGVHVLSCFGFFYMPMDPTERIVDAVTRIHKRLFWLDHNYRVLSEATSKAKQFTVANVQFWRHFGTVRLDYKPTDSVQATLMPGELLLQGSPNQLGCKERYAVQRPPPLRPSPVRLPEQDKPQSPQQPPPGDDAVAVEKKQRRTTRRMDRETTATPTIEFKANVEDWTQVDVKKWIIYVVQAKSVAHKFAQVNGATLLEWAADPNLEQRLRDDLKIHMALQRHKLVVRIQKLVSATKQNPSRRPPRPQKTSGDGEGHDATGDKSDDEESREKADKEVVLEEDTTPPRSDVQDDRCGDCHDESECHEDLSHQLHDGGDETTSPSGDETQLHNGDDEKSPCGDEDLPPFEDDGDETLPPFGDEDLPSFDDDGFVTTSGRAASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WMS2</accession>
    <name>A0A6G0WMS2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_013613</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000175">
        <property type="protein sequence ID" value="KAF0728655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WMS2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006243"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0728655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="472" mass="53911" checksum="85E4A302E31CD116" modified="2020-08-12" version="1">MFGAADTRPAPANATHAVLTDLGYTPTRMDCDMRLTTPIQIPKASGVVVSANTSMSRIFPKSLCTACTPIVEFGHDICELKFTYNATAQTMTVLSSKAHIGGVHTVVRALCVLFAIFGYIASQRTIRWCDATALSTWYKRAIYTLSPPIYRYSSYAFSFSSFCLNSDWFVFGYVIAVLLDEKQSMIYSKTMYTWNEHSDNYWIPIQLFAIQFRWLWLNCAFVKLFKLILNFVSLTRYTGKNLLVGLCNFSSHDSRHQPRHGVFNGYYMRTVPDILFIMTINLMVVLTIDHVVHFRWWQRVAKSSLGRQTMFNSTSILNEMRCDFYHIDGYKNQAVKIQARTLCTMQWFLMCHTICFGLPEDPKHIRALLSHSAKSDLHVDRHLSKSKEKSITDLLKLNNSDRSTSPGSTRYLVVRPKQSNDTDDDPPEDSIQICILTQDLDGNIRMYDSRRSELVGLSVEVKILNNGKFVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WPM3</accession>
    <name>A0A6G0WPM3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hsp70-Hsp90 organising protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Stress-inducible protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_013099</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acts as a co-chaperone and mediates the association of the chaperones HSP70 and HSP90 probably facilitating substrate transfer from HSP70 to HSP90. Stimulates HSP70 ATPase activity and, in contrast, inhibits HSP90 ATPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer. Homodimer. Forms a complex composed of HOP and chaperones HSP70 and HSP90; the interaction is stronger in the absence of ATP. Interacts (via TPR 1, 2, 3, 7, 8 and 9 repeats) with HSP70 (via C-terminus); the interaction is direct and is stronger in the absence of ATP. Interacts (via TPR 4, 5 and 6 repeats) with HSP90 (via C-terminus); the interaction is direct.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000166">
        <property type="protein sequence ID" value="KAF0729355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WPM3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016333"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000020">
        <property type="entry name" value="Stress-induced phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047150">
        <property type="entry name" value="SGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831">
        <property type="entry name" value="LD24721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831:SF2">
        <property type="entry name" value="LD24721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="7"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="209"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00056105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00066016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00074766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00076447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0729355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="263" mass="29376" checksum="DA993DB150C88E10" modified="2020-08-12" version="1">MSAKTQAEAKKNEGNEFFKKGQYAQAVEKYTEAINLDPTNHVYYSNRSAAYSGQSLFAEAAQDGEKCVQLNPQFVKGYHRYALALKGTKQYAKALEVLKAGQKVDFDNKDLNKLINEIEPLLAKVEQARRSGLSPSELLKEQGNDLFKAASFEKAIEVYTEAINACEKDDSPVAISCYNNRAACHQQLSNFSAVIRDCSHVLEYEPENQKALLRRGLAYEGLERYRLALQDIRAVLALNPNIDIANKAQHRIGAAVRALKDNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WRB5</accession>
    <name>A0A6G0WRB5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_012486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000158">
        <property type="protein sequence ID" value="KAF0729997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WRB5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013776"/>
    <dbReference type="OrthoDB" id="67317at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0729997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="113" mass="12708" checksum="6AE6B2ABBD28A7D6" modified="2020-08-12" version="1">MRPQLVLCAYLSVAGVVFLSLLGLILYLQPDYVHGLDATIPKHRLAINCWLGAALYAGTWIVSIISLCIHARHEAFKKKTANKLLEMQRSLTSWEDLGMPARIEDEETDIDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WRI3</accession>
    <name>A0A6G0WRI3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_012498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000158">
        <property type="protein sequence ID" value="KAF0730009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WRI3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011312"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027948">
        <property type="entry name" value="DUF4436"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14494">
        <property type="entry name" value="DUF4436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0730009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="34349" checksum="726AAF2C4E5435DC" modified="2020-08-12" version="1">MASSTYSDLESPAIAAKPKLAHRRRYLPLLLVPAMVLAMVVAFFLGHAIHSQPHQNGYRVLYKAQPTNNSGSTAVAVTVVVSAVNLDTYATNVTLTAHLDNADAAPKAFQLELGRTLVNVTTPLDAPVVVKSPFIKGTQTMYPFDRYLSSFHVMAKTTDNATTTQLPVALTVVSSDSIAWVTSVRPTSRSDFDVDPPSGSLTIHVRREFNVYLVVLFVCIWGVTAAVGYVGSMTIVWETRPPDNPSMFISALIAIPIFRNTAPGAPVYGCLFDIFSTFISFIVTLVCLLYVSLAYMKPKPPHPVVVTWDDANPCTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WSB4</accession>
    <name>A0A6G0WSB4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb/SANT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_012320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000155">
        <property type="protein sequence ID" value="KAF0730322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WSB4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005560"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024752">
        <property type="entry name" value="Myb/SANT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46929">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46929:SF3">
        <property type="entry name" value="MYB_SANT-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12776">
        <property type="entry name" value="Myb_DNA-bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like" evidence="2">
        <location>
            <begin position="11"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0730322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="210" mass="23646" checksum="3CBDACBE5D8C68D1" modified="2020-08-12" version="1">MAMQSTAARAKWNTEKDAYLIKLLLRQKDAGKQSDSGFKKEAWTTILAKFNKQFSVVLDKEKIKTRHNQLKANWKLFQSLKDDSGFRWDAEKQRPTAPDNVWEERMASATKPVQTKLKQIQRNGMDNQDALGELFGGSIAVGRFASSVGGLPDVSDGDNPPNSDESDCEHSLETATEYGEDISSPEQPQKKENRAIACQKHPWRCNCEVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WSI9</accession>
    <name>A0A6G0WSI9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_012145</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000154">
        <property type="protein sequence ID" value="KAF0730445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WSI9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015945"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="140"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0730445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="239" mass="27057" checksum="A04C16EA3F2322D8" modified="2020-08-12" version="1">MVFEIKRTVQEELEWMDGLRCTDAEAAENVLSNSKLMVELAAGGEVGALKEMIHAVDALDAHVLTYYYVKMFQEASLRRRMDVLKFMVDNGFDVNHPFVKDTLHRVIEECSDEHLDDTLQPLLHFLLQAQMDVNFQRKRDLFTPLHVACAKTFLGVASILVMYGADVNAIAKEDLMPLNCAERVSDEVNDKLVALLKDAGARRTWRRQNKSTSQMKIVSFSSLQLEPQCGLMLSTSDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WUD8</accession>
    <name>A0A6G0WUD8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7769 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_011662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000147">
        <property type="protein sequence ID" value="KAF0731119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WUD8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017238"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056671">
        <property type="entry name" value="DUF7769"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24964">
        <property type="entry name" value="DUF7769"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7769" evidence="1">
        <location>
            <begin position="8"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0731119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="425" mass="49150" checksum="18E75CCB69FE1512" modified="2020-08-12" version="1">MPTSKPNLTDEQRAALYLELAKRSCNGMVSRGIMEEVCSFFSVTSRTGWCIWKRGNESHEVGQAANVRSNIKGHRGRRRVYAPSDIDEKVKAVELHKRQTYRSLAKETGLSEFLLWSYVKAKWMNRRSNWARPALSDQQRACRLAFCKNFVDMNYASYDVVHLDEKWFFMAKIRRKFLLWHDEAMVPRHVQNKSHITKVMFLVAVARPRGDWDGKVGCWPFVTKVQGQRTSKNRRAGELVLTPVSVTGAIYREYLCDLVLPAIKNKWVWPSNEHGTIFVQQDNAPAHSRLDDAEILAACNSDGWNIEMRFQPAKSPDLNVLDLGFFNSIQALQQRLECGTIEELIDAVKISFHDLERLTLEKTFRTLHRVVQVIIEFKGDNRFKIPRSKKNEDESLALQLMHARIEEEERMDSLADLFGTVRFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WUP8</accession>
    <name>A0A6G0WUP8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RanBP2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_011443</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000146">
        <property type="protein sequence ID" value="KAF0731177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WUP8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019786"/>
    <dbReference type="OrthoDB" id="70846at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="6">
        <location>
            <begin position="59"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="239"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="373"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="254"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="373"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0731177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="421" mass="45862" checksum="2FCD0DF2A2B25145" modified="2020-08-12" version="1">MPHFNHEAFTSSYKMTKPTKDDTVNGPSCPTCTFINKPGSALCAMCEQFIGPPAHAIHSDGSWSCGSCDHHNENGMRECYYCDAPYVSAVASSVPLNIFCSRCGVRNVGTAGTCVACDHTLISKFESIKHEWSDTTNFVARDLGLHVKVKCPGCMKVCNVPSSACFRCGSCQVYFAAPSVGDVTSFHVSRLTRSLSTSVMNLFQKKKDAPENTYKSQPPRKGLASSFLDFFREESSDSESDDESLLFGPAHDASSPVRPLRTSTTTSTPPSEPSIPIGIRIPAPGEKPMTSSLTSSGASSVAEVTPPTQQQPAREWKPIPNRNYGFNHNDLPPPLTPLRKSKSVPVSMHSFEREWDLRQQGDGLSSSMVFVTSDDEEKEELQDQDILDSLRLSSSSSSSMKRGSYGGNNGFHVPNAETIEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WV02</accession>
    <name>A0A6G0WV02_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_011365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000144">
        <property type="protein sequence ID" value="KAF0731301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WV02"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005612"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0731301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="138" mass="15950" checksum="1A2A1F2A21D1BF31" modified="2020-08-12" version="1">MPPTYTWICQPADVAWMKPMNAAMRKRWVEYLRDQVNNKGDSPFRIERPDRFEIVEWINTAWEDLSMSTIVNGFRKCGLIDVTYASDENMDDYGGEEDDLFEAAGVLESLMQCGVAELIELESEFCFDDDDQQQNNTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WWI5</accession>
    <name>A0A6G0WWI5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_010945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000139">
        <property type="protein sequence ID" value="KAF0731844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WWI5"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0731844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="83" mass="8948" checksum="3876AFB5D6963E9F" modified="2020-08-12" version="1">MCAKTFIASVLQVAGRMVPRPLEEALHATKPNELIRADFLTLPKDGYTGWTYVLALKDDTSAFCLLIGCQAATAEALADALVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WXK5</accession>
    <name>A0A6G0WXK5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_010582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000135">
        <property type="protein sequence ID" value="KAF0732292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WXK5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000310"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="18"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0732292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="156" mass="17136" checksum="9E7CD48E8C6746FE" modified="2020-08-12" version="1">MEEPKLAPIPIQICRQVMSALVELPVEVLENATAFLDGKSVGRLSQTNGALRKTLETSMVWKTQVAAQFGIQDSAFPAQSPCIWRSIFANLMWDATFVAQAASAHDAIQVVESAPVYAMASSSAKSIRREILLMEALRRFPTSSSLVHLYATLLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WYB6</accession>
    <name>A0A6G0WYB6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Crinkler effector protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_010286</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Host cell</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000130">
        <property type="protein sequence ID" value="KAF0732578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WYB6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014155"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043657">
        <property type="term" value="C:host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045379">
        <property type="entry name" value="Crinkler_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20147">
        <property type="entry name" value="Crinkler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13365">
        <property type="entry name" value="Trypsin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Crinkler effector protein N-terminal" evidence="5">
        <location>
            <begin position="3"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0732578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="342" mass="37994" checksum="1C4B4BFAC511AF5B" modified="2020-08-12" version="1">MPTLFCVIVGEGKPFPVEVDADKTVGILKQKIKQENTNTVTCDAKDLELYLTLNGLSRDEARVTKLDDDGHVPGCIKMDELLQIQNVHHFGMNFQPKEGKIYVLVVVPAHSAVPSYFILPETRDSVANAVFKIVDENEDEEYEDIGMGVFFSPTLAVTCDHNLASKHTIGSMVTLAMRNEVMDAVEVVARNSTLDFAILKASEPKSFIAPWNGSPNSLESRYDLVLASFRIGIDEYQAPYKGKLGFAPAACIAISHHKRHIMYSCPTYAGDSGAALIVKDGFLIGIHLETINALREEIERKKVIKDRLNDVEESLDMIVRSGLAQWWSALLVHKFKDVVKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WYP8</accession>
    <name>A0A6G0WYP8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CBM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_010349</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000130">
        <property type="protein sequence ID" value="KAF0732641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WYP8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015135"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026299028" description="CBM1 domain-containing protein" evidence="3">
        <location>
            <begin position="16"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="4">
        <location>
            <begin position="229"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="4">
        <location>
            <begin position="273"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="186"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0732641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="313" mass="33222" checksum="943A2F1E07B2689E" modified="2020-08-12" version="1">MQIAMLASLTAVVFGHGQLLDPKPTYLNQYGDTTTFCGVIDGPTTFPGENYDLGPSSNTQAFTRQFDKSGFASLKAFFDSRETGGECGITKADGSPQALPIDGVLKWGIGGSEGFVSSHEGPCEVWCDSTRAFHNDNCAKNMPNGHIPIDMTVCQGAKKLVVLWLALHAPTWQVYKNCVRLSGGETSTPSSSTPSMVPVTTSPASTQSSSEYPSASTATPSSTTSNSDQLALGWRQCGGSIGYNGPTNCIRGFHCVGFSAHYSQCMPNEPPQGQLQTYLQCGGRGYSGLTQCKDGDSCVVVNEWYSQCLPGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WZF1</accession>
    <name>A0A6G0WZF1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_010083</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Folate-biopterin transporter (TC 2.A.71) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000127">
        <property type="protein sequence ID" value="KAF0732978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WZF1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004019"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039309">
        <property type="entry name" value="BT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585">
        <property type="entry name" value="FOLATE-BIOPTERIN TRANSPORTER 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585:SF5">
        <property type="entry name" value="RNA-BINDING S4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03092">
        <property type="entry name" value="BT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="468"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="494"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0732978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="543" mass="60536" checksum="9FD6800D0B3F1862" modified="2020-08-12" version="1">MVSQRGVGDFEERLSYVLSANGDDKANVYDVLKSPRDLEDGALTEGGALHLFSREAMYLFSQYFCIGVLYGLIPALKYPIYNVYLGMEPYQVSTYNVLVNLGWSFKVFFGMLTDCIPIFGYRRKPWMLIGWIVAMGCLICMVSMSLGEPYCNREKTTTCLLPRNKVNDSDFAANYNPDAPNKGTTFILLSILVSFGYVTSDVAADAMVVEYSQREPDYSCSIAVCISAFGLNGVKYGGTFSFSMAPNVPYGICLIPSAVVLFTTIFVVAEEKHPGTRFSVWWNSFWQLLQQRVMWQVCAFKFINNVFNGMSTTADNGMSKVWAKVEPLNDSLQLLLAKVIYTIILSVVGKWGLSWNWRWIIALSSLAVVFIDMIVQFLTAWDVVRNQWFYTGVALSENIPDGVRFIVSAYSAIEIADPGTEGATYGLLTTLGKLATPFASVIYKYADSFFKLPNNDFMVDSNQVRWDVTYVSIIAYCCKAFSLVFLRTGGKSKLAGMLLVVLFFACLSFSMVSSIMLIFPSTKCYRIAGGNGKLDPKTGKCPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X0F1</accession>
    <name>A0A6G0X0F1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_009818</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000124">
        <property type="protein sequence ID" value="KAF0733254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X0F1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017751"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0733254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="196" mass="21526" checksum="666034E7AB7E17DC" modified="2020-08-12" version="1">MCKDVSSELRGWGLHDELVAMYCSNNVGKTLVRLAREGFQCSKGGLLLLLCPNLEHLENSKAYFHGGNYALPAGAPGHVNWPGGAEPRHGDPLSLGVDAVPPYALGRFIAKNSPQAMDKTDGTDLSVFYLPDFATFGRLHEAVRNSLQFRRYGRVEARIKSANANVPFREQLPLVKAFLLDKVNGRPDPFEGFTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X0G7</accession>
    <name>A0A6G0X0G7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_009826</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000124">
        <property type="protein sequence ID" value="KAF0733263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X0G7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004862">
        <property type="term" value="F:cAMP-dependent protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034236">
        <property type="term" value="F:protein kinase A catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050503">
        <property type="entry name" value="cAMP-dep_PK_reg_su-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635:SF166">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="579"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="3">
        <location>
            <begin position="553"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0733263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1030" mass="114314" checksum="B92A7850D6DBC74A" modified="2020-08-12" version="1">MAASAPWNSDVFTGLDPQTSKPSTAHHQKRFPEYHYPDDLDLSQSFPVTVAKGRDLLLPLQPLHHALFPDVEPPQGFSLGFSVSACSGSMAVAMLPISSGAPFDLSTNDAQCFTFTREPNATTPSLCPLYFGADERFYRYDPRDIQGIVLMADLDADLHVMVSFTSTATFSGFNRMFNATSPLHFDISQGSSSSASQASFDLPSLVSLASSKDVPCVNCTFRVFLTPSSNESVAPLVLPAACVAKFPLQFQLESPSPSASSANVTAAITSLSSLHKGWYHVYLVADLNEHPARPALLVYPPQTAFFQPDWHWTYIVMGSLAAVGLIAAVVAAGKRHGIWLNGSHKRRRPSHRQEPSAVASMEQTDEHVGLLSKSNYHTLVDDDEESLDGYDEIPHYDDVTSTSVGESMAAATSAASLSPTKLVHLREEHRKSLQSNVEQFKHLQALSKKPISPPQPTTLRVRATNLASQDEVDRNAAICRAVLVLWNNIQKMRCLRRWRDVTNDENQRIHDTAVRTVQQSTRELLAAKARGDIAAYSSEQVALLVEWAVQTKSFDGIDRVVLEDVVQHMHLRQLKDKECLFFEGDVGLFYYFLFTGSIAIYVDMPAAAKATLASSRHEAVWNARKDPTYLGTFMYHIPEGDGFGEVAMFNDEARRTASAVAAGPCELIEIPKPVYVRTLLPHHFAVYNKAQKMAFLPSVDVFADWIQAKIAGLSDLMERHDLAFGHRLVVADRPIQALFVVISGEVRVTQPWLTPVAEHKQAIHTQLKQPPKKYIDVEVERVGRRGYVGLPLLLFSDAKSISKVDAVVSTNVAEVYILKRDNLAAYRALMPANGTAQVMRRWNDQQRQRTERYLRAVSVLQRVNSAQPSEPQPATVDEDEEKDKLPLLPIMVSSSGKKFLFPDWDLLVDRSNKPVVASMAAPPPFVHIDPSEQGKIAAQSFTAMSEMPHMFQWDPPHGFSVQPKTMSFLVPKAPPRLEKPKASMPAMDKTFERSISRTRQLARAVVKEHNAFVKSRAIATPRPSSFKHSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X169</accession>
    <name>A0A6G0X169_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sfi1 spindle body domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_009553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000121">
        <property type="protein sequence ID" value="KAF0733621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X169"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019563"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019902">
        <property type="term" value="F:phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052270">
        <property type="entry name" value="CACF_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22028:SF9">
        <property type="entry name" value="SFI1 SPINDLE BODY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22028">
        <property type="entry name" value="SFI1 SPINDLE BODY DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0733621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="561" mass="67260" checksum="609380E9E8B82571" modified="2020-08-12" version="1">MPQEDDSRLRCDVLSAWASITQEKQRRQANRRRAVRFHYFKLLRQGFEAFRYPIQTQQERIQVLNRVSEKKLQARCFYAWLQHVRTRQVQARQELQARQNQLQLAFYQWKALHLKRIQDERDERTTAHFHRNKLIHAFFIRWKAFVKSRHHLLARVEISFKSHEVQDHQALQLTCFQQWREHTQSRVAQRFIIHRAQTHYELALTKRVFQAWVQFVGIRMWEEMIYLRAAKHRMQVLLRHCFIGWREKVHVWKQARAQTTMALTHWKMTMQRRAMKAWIQGVHIRQAKRHFRHEALEWRHALFLRQGLAHWIQAAFVLQEERMKEVQRRAALASDLLWRRIARIASHWQYVAVNHLIKGPRGPRLTHEHMTYPTPARNISFHDIVQPLGMSSVVVTSAPRRPQPRKPLELLYDGDPKQSPRSSKLDPVHIEPLVPEKEIPPKITDTGIRKYGIQIPPPRPISPKAVDQDLESLVDDMEARLQYWHEKKTEWKRHKHQLDELRLHLSSKTLPESTREVLQRTLEVMEATHRDHLAAHAASKAEMKSFAHQIEVLKSKRRNVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X1C5</accession>
    <name>A0A6G0X1C5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_009491</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000120">
        <property type="protein sequence ID" value="KAF0733646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X1C5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019480"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15745">
        <property type="entry name" value="FYVE_RUFY4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="8">
        <location>
            <begin position="302"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="7">
        <location>
            <begin position="834"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="359"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="710"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="361"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="392"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="409"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="427"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="448"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0733646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="880" mass="98253" checksum="AB04D70BF7D1E0C1" modified="2020-08-12" version="1">MSIPLPRQSAFADSLSALPPLKRDEVVAYMNYIDDAVDSAICLINGLGNIRWQPVKQKGEIVISRAADEANSFSNQAAVKSVCTVNASFDEMMEHFITETTDIFREREAAIHGAEFLDGAVLHVLHPRDYSSDDSPQRFVCIKWHCLKAVAAPTKPRDYVYVEVVDSFVDEQNVRIGYRLSKSIELKNFPSFEESHRFVRASTLNLHTFHSVEMPTHPRPSGQSNGSHNMSPSAQGTYQVELRSMVLGDYNGRLPAWVVNKMSDLAALRGQAIRDFFEQQRLSTLQWVPPHNYVPVSKRAFCVICTRGFSLVRKKYNCQACGEVVCNQCSIIQSIGAKKIKTRVCIGCNLQARTTQLTTGSSRSSVASMASRPSSASSLQSPNNSFHHHSNHNSIISNPRNSSHDSPAFNHSHSMSELSKSWGPSYRRSQSEMPTEQSYVRGNVPTVRPTSSSMPRTLSSSASLPPEIATSKSLNSEILAHASIPTYQEPAPREDLDLGLGSIKISDENVNGDPLNLDMNVSIVQPNQQDYGRVSEALSDITARNSEIVSERVSERMSERMSELDVDAYDDDSGDDDGKCGRPTYNIVEEESSSETAMTSFVESTVTVATEDDENDDPVNYRPSHMAAEDYLEATRMTLAEITRGMQSVQESTELTALKLEEHEHEQVTRMSMMDHSRMSVMDHTRMSVMEQPRMSVMDTPPDVENLFVVLKLNAEIDRLQHKMETVQEGTIQLNQMNAAMNEKIHTLENRKAVVEESTEPPAYLMHKMDKINEDLKQIQHNMEKVQESTMAIESKLHENEPPAVEVPMLPESTRGGFVSFLEDSSFVPANEADAAPEGWTSVHSKVTGKMYYYNASCGQTSWTMPEEDDMAITKNYAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X254</accession>
    <name>A0A6G0X254_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RCC1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_009446</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000119">
        <property type="protein sequence ID" value="KAF0733889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X254"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001453"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF408">
        <property type="entry name" value="OS09G0560450 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RCC1-like" evidence="3">
        <location>
            <begin position="74"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="75"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="127"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="176"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="232"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="302"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0733889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="470" mass="51723" checksum="2609C0DA03EA024A" modified="2020-08-12" version="1">MSDWATAAQWKPERVDGLPRILTTAAGAKAAYAISGCAYSLAANDKGFVAPRRIAPFHVQRKGSSNEPESNAEGGVLYSWGCGDFGQLGHGDDENVKIPRPIAGLETVRVALVRAGTHFAAAVTDSGVLYTWGNGRHGQLGHNSTESEPSPRRVEGLSNVVDVSLGSTHALAVAGSMVFAWGQQQSGCLGIGGQDRDVLVPTEVMFFRHMQTSKVSAGIDHSLFFCIVGVKTFVYACGSNRFGQLGINSTIAFSEIPQCIEEFEYAGLTRRVAQIQAGDRFSIALLGIVFSEIVSKLSVVTGEVLAWGDNMYHKSAHSKARRLTCVPWVIDSIAHRFALQVAVGHSHGLVLFRRDDKVMDRFRRFPIRRLVAFLHRDEVFPTQLESVVELPQVHDLCSPRKCPQTILPPFGMFYRCKTCQVQPICRRCARHCHVGHAIEWEVLDRIPHSCQCLHTSLEPYPEEDNNDTNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X2S5</accession>
    <name>A0A6G0X2S5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_009055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000117">
        <property type="protein sequence ID" value="KAF0734188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X2S5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015272"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07440">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF192">
        <property type="entry name" value="DOUBLE HIT, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="166"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="315"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="499"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="636"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0734188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="797" mass="90729" checksum="86610ED8D2448C7C" modified="2020-08-12" version="1">MGNAVGRPRRRSLAIHTDEFGPHEEEGAAAVHDANTNRYRQRSIKYTKRHNDKPSERRSAPPDIVVPFESSPSSNCSDVTPPLAPLPDPLIPPLEAKGERPPAHVFQPGNNLVALKYSQRMPTEKMLTKAGSVKSLSTHTKNPMKYRRQSICPDLTANLSMAFTVDVLADPVTLQLMIKFAADVPYAAERLHFWADAQHLRSLPSAQYTDKVLRKIYEKFLSATAPTPICVPTAMLKAIRAAFESPTGIQSAGIYSEAQALCLRDLEKDVFPRFRKHQLYADMCQELAEKPSKWRVALGGVLQSSHLLAHENHDAFLGVMNNETKLRYFKSYCVENLTLENLMFHMDVEEAKRLPNQSFIQARARKIIDTYFRSSSKMYIHLSPAIHDSMLENYHAGAFEPAMFVDAQFVAMEFIRDQVWPKFSASPIYVKHIQASSVAESELEAYVPNITTQDVELLLADLDSMSSAILLQKAMELPVHLMANIARAHQVHHDTALLLLQDKIAHRIFKKFLRMRGKEHYVAFVDDVEEYTSLPGIEFMQHTAKKLFKKYLSDTAKLQVDMSTKMRQDIESKLDVPSIDMFKPAIFKVKTGLLQDSLMRYLMSPIHTELHEDPDIPHLVQEVTAARDCGKLDLPHLESVLSHPKYVGNFRKFLATQHATENLIFLEEVEEFRRLPSSQIVLRNAKKIVDKYVNKETAKSPLPLNDRLHDTIIAQSDGTEKTFFNGAVHEIMHLLRTEEVPEFLDAPIFMILVGAWAILDETYARKQLVGDLELAYFRHRFHAICESKRHRRNAHDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X2T3</accession>
    <name>A0A6G0X2T3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_009044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000117">
        <property type="protein sequence ID" value="KAF0734177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X2T3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013311"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0734177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="301" mass="32323" checksum="D32B8408846170F6" modified="2020-08-12" version="1">MSPTATITRASSAKLGKQKAQAGGQNREIENESNEAEPSDVSKTTTKNAASQSEMESAIVQDVLQEVGMNIDESVRSLIANRLAQFQLEKLNKTSNPPKRTKGPKDKKHDNSSKKKNDVKQKDSNKGTASGVVAVRRSKRLNGGRHPSDPGDDGPDDLPDESSGDETYSLMTSDGDGINASADGGGSSPDDDSNYGDHGDGSNGSDFESQSSGGSNDVVEVKASFTNPFKIAPFDGKDWTTYREDIRAVAERQGVWNIMCGKEMTPNKSLKPKKYGDFQKRAAIANELLITSLDKSSKVTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X3X6</accession>
    <name>A0A6G0X3X6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_008833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000112">
        <property type="protein sequence ID" value="KAF0734485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X3X6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000517"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07307">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0734485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="441" mass="48189" checksum="BCDADA144A784402" modified="2020-08-12" version="1">MSSIRVRATNKLLTKLGATKPSKNVPYEQAFNGFDQLQSGIISLDSALKGFIASLRGFHAASNVLLRAVEDVSNFKCTDIPSESPEVKQFIEVFKACSINIDIGQLTELAKKFETRVQSPAQGWVHQVNTLQKECQDFDEVHITYDHYTKKVVALREAHNKRAGAGKHEKSKEVDKLMRNEQKLVSVTNEYTQASDNTTQHLQDFLRHRDSTLLPLVQRLIEFRLDYSTAVHEATKKMEPLLKIDGYDEHLAVLEAYTTNGHAPSEKTPPRHESHIAASDIQVNKLSFSDFVGSPTDETTAAATTSAPPSSDSWGDFTMEATPPPMASSIPVSMASFEPFSATPPSPIAQSRTASGPRTNSGKIVNVLDFAESPPPQPAASDFMDFSLSDLKGSGQIYATAPPSSDFNPFAPQPPVPATVHAAMNASQHMSARPATSFDAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X402</accession>
    <name>A0A6G0X402_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_008708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000109">
        <property type="protein sequence ID" value="KAF0734630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X402"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003821"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23313:SF0">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23313">
        <property type="entry name" value="TSEC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0734630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="300" mass="33618" checksum="C277F4110D348970" modified="2020-08-12" version="1">MSESLTARQAQLLQANETLNAQIQKTQEHVQLVMEAKPTPRKVSLIAEEADEDQVSMLPQPMSSSKASLASGDAGRQSSSSNLRRPTATSRTNLHEHGEENDPAFRYQRAQIRVLQDELAKLLEGQKNAVPKHDAVAAELERAQVDHNALSEHVQAMQVVLEKNKKLQGMQEAKQRMLDTDIASARVQVANTGKNEKQLTRSAKVAEVRLNECSEELSAAKKELDDEKSNQGGHAVPRHEHERALKDHQRLEKQKADLIAAFKLQIHLIDVLKRQKLHLETAKMLSFIEDEFTKTLETSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X4E6</accession>
    <name>A0A6G0X4E6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_008605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000106">
        <property type="protein sequence ID" value="KAF0734754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X4E6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016613"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0734754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="456" mass="50495" checksum="90DE792BA03A1AC8" modified="2020-08-12" version="1">MNSVPNARLRIVVDDMLYISKFPSTDHADEISSGVDFTRRRSCCRVIHAWLTSVHLCLGFVKSINLSFPFPPCATPSAMKSVVLPLMPTELSNVHSPSISTLTFFNTTAPVSDTNQSRTFLQSRVDAIVQVNPWLSGQIQTSAHGGSRLVLRYDANTSSLPVEIISMPALSPSLEYEAVAGMLSSLEAPQGSDVVDVVHAALFRVYWITISSSQSALFVSMAHGLGDGYTYYRIYGMLSADARVEALLPDRVDDFQRVRAAAISDIDNVLSMLGRAARQESTKDERSRRTLHTIDPAWIANEKAKASRMVSTNDILTSWFFRQTKADIGVMVVNLRGRAEGLEPHMAGNYQTVVAYQPEDFATPGLIRESVRHGMRRACSKELPHDVRTVSLTTSWASLYKQVVLPAWKMAEHWPITNGRSMFSNGAVIFQRTPDSIGVLMRTKHDVAKQSTLFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X4S7</accession>
    <name>A0A6G0X4S7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_008512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000103">
        <property type="protein sequence ID" value="KAF0734848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X4S7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010389"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="86"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0734848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="520" mass="58779" checksum="8045A25458466FCF" modified="2020-08-12" version="1">MERPPADVEFGSHALLRRHTRTFQDPHLVPASVQLHRDNVRALKAKLEPSFRTEFPNQLVLNRAAIDREVCFTGGIASLLDAEYIIMEFLPPDDLLSASLVCRLWNVLSRQDSLWKKFLTSPAEGYPLRQLLGLEDELRIPAIQVYMLFRSCGVLKSSWIDVCKSVHLGSPALTHGLQPLSQWLSTQSTPLHPPLLQAMCRQFLMACIAAESIGVNFESISFDSIHVHRTSTAQAPLLQIVNMPHDREFFRRRNEDELLYRRRTNGSAIGMAFLYGAMDLCAGRELMHESLIRRCLNDREHMSMAFKSMVEFGIYVVVAGLPLSTILEHAYFDDTTTAAWPVHLHLDIDSSMAYLSKIVGWYTDHPRHPRATPSRKNVQVPSTSLAATACLAGDVDRVALRSYRYTSLRAPPEADTLWMELLAQEQKHTLQVLDLSQATPLPTTTILRTLESLDMLTDLILPRTVFHNNIELLVQAFPPNLSRLKRIDKAFLTALDSLDTSYERQLNIVSFAYGSHVQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X541</accession>
    <name>A0A6G0X541_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphopyruvate hydratase</fullName>
            <ecNumber evidence="4">4.2.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_008472</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Mg(2+) is required for catalysis and for stabilizing the dimer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the enolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="4"/>
    <dbReference type="EMBL" id="VJMJ01000102">
        <property type="protein sequence ID" value="KAF0735000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X541"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000075"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.10:FF:000001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.120:FF:000002">
        <property type="entry name" value="Enolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902:SF1">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00178">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enolase N-terminal" evidence="12">
        <location>
            <begin position="3"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase C-terminal TIM barrel" evidence="11">
        <location>
            <begin position="145"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="383"/>
            <end position="386"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0735000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="453" mass="49153" checksum="66D4575C9DFFCDE7" modified="2020-08-12" version="1">MPIQSIKARQIFDSRGNPTVEVDIVTEKGLFRAAVPSGASTGEFEALELRDGGKPYMGKGVQKAVDNVNQIIAPALIGKNEVDQKELDVYMVETLDGTKNEWGWCKKKLGANSILAVSLALCKAGAATKNIPLWKYIAQLAGNPTPCLPVPSFNIINGGSHAGNKLAMQEFMILPVGASSFTEAMQIGTEVYHVLKKVINKRYGLDATAVGDEGGFAPNIQENGEALRLIQEAIELAGYTNKVQIGMDVAASEFYTGKEDARYNLDFKNPNAEDKDKISADELIGVYQHFIEQCKDHSPIVSIEDPFDQDDWASWKKFTATVGTHVQIVGDDLTVTNPTRVQKAIEEKACNALLLKVNQIGSVTESIQAVTMSKKAGWGIMASHRSGETEDAFIADLAVGLSAGQIKTGAPCRSERLAKYNQLLRIEEEMGPSAVYAGNNFRNVEALGKYSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X5T7</accession>
    <name>A0A6G0X5T7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_008222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000100">
        <property type="protein sequence ID" value="KAF0735310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X5T7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019486"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13527">
        <property type="entry name" value="Acetyltransf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="36"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0735310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="111" mass="12581" checksum="9DCE842E020C24A8" modified="2020-08-12" version="1">MITLPFQVGFRPLSRIVRHYHESEKYTLEHASANAGWICVVGVAPEGQGKGHCRRMMETAIDAMRAQGMDEIWLTTDKDVNVTIYKKLGFQVMTEKVISSSGVKSWTMKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X744</accession>
    <name>A0A6G0X744_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_007785</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000093">
        <property type="protein sequence ID" value="KAF0735780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X744"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000900"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="59"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0735780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="325" mass="35516" checksum="0A082A8CB4A68F88" modified="2020-08-12" version="1">MISATRRRLFHGASASAHPALYGVAAAAGMAAFFLSEAVPARTDPAASMLIKQPVESRYQIEKMIGQGGFAKVVAAREKISNTPVAIKRVSKSLTSKAKFVHEVSILKQLQGANHVVQLKDAFETPEDWILVTEYVAGGELFDRLVQTGTYTEHGARVITRDLAETLIELHALRLVHGDVKPENILLDSNQDGAHMILIDFGLSFHTSEGRHFWDGSGTVAYAAPEVLDQSPNVMTAIDMWALGVVLFIVLGGYHPFDPSNNLPDAALRKAILRGEFDFDHPAWESISDEAKDLIRRLIVVDPTQRLTAAQVLAHPWLQATAPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X768</accession>
    <name>A0A6G0X768_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_007868</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000093">
        <property type="protein sequence ID" value="KAF0735866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X768"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0735866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="165" mass="18428" checksum="A508026F02F772A8" modified="2020-08-12" version="1">MERQNSESQSLIRRRVWCSVPLSSFALECPSNPVFSSSNKAADVDRCDLRCGCNTLREGLTSCSHSRNVISPQDSYSFELHVGSLSRRRGTQLFCCRLHSTTNSQTSHVHGQLTALTGSRITGYRGMDCHVYLGFSQCPIRLIQLGVQTKRQEILADLDFCGPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X7V8</accession>
    <name>A0A6G0X7V8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_007643</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000090">
        <property type="protein sequence ID" value="KAF0736056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X7V8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002106"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40855:SF1">
        <property type="entry name" value="CLAVAMINATE SYNTHASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40855">
        <property type="entry name" value="DIOX_N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026347108" description="Fe2OG dioxygenase domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0736056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="462" mass="49419" checksum="29E980AA9B0660ED" modified="2020-08-12" version="1">MQLSIAVFACVAAAVQATFPTYEIPAFDVSNSADASSLVAALKSTGIVALKNIPNYEATWETYLEAAARCVSASHENVIHKRLVDGTQRRTLSTHADSDLVPDSLVNSCPDYVQGLKAFNDVVDQASLAFAKALDASTTEVSAKPMETVMTTGKHLNHLHSYENPAPADAVASDLSLELHTDNGLLILMSAPRFVNGDNQVVANPDENAGLIVKLNGTEYRPQQKDNELVVMIGQAFNEWTNLGHQFPAVLHGMVMPRNAPADTKRLFFGRMILVSDDTVLANSQMTFKEYADSNRRFLLGESTEVASFACPIHRELASSDPSCTIGIWAPSNESSPNVTAAMCMRDCNVDSTASMMKAQYAQCLANKCVKTSEVANGGTMCWMLCVQKFTDDVCPSKSSQCVDQTLVCQGGTVAPSATNTSNSSSTTTTTTAAPTTTQKSMASTISMSATFIVAAILAVMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X7Z3</accession>
    <name>A0A6G0X7Z3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_007211</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X7Z3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021548"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="5">
        <location>
            <begin position="270"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0736188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="396" mass="44444" checksum="09327C464DDDE37C" modified="2020-08-12" version="1">MGKPRRPLPIPSNCPPLSRQATEVLRSRALSTAMDVVAMAQVGGGPIQWRVWSREGDLIIYQGEDPSGPHNVCPMMGWMEIPGSLDEVADLFRTDTLQHAAEYTQRFCPDVDAVLTLYTIAQLKKLNDDMISVTWRASKSGSSPFALKRDMCLLECHHAFQLENNRRGRVCAVESIDMPCCPDFQAEHGYIRTQVVSSGHVFVESRLKSGYLELSYVVRGDLSTASSLGRWLAVKAMAKRCRSIKAIDAWLRQNRVNRTPFLPVAKVVPHRSRRQCHLCRKVFHALTRKTTCFKCGEVLCSPCTTPQRVEIDGKKRRLDVCTSCCIRPPEIKDVGLIETTAVTEQGSDDGGWLRQRPRRAYSAYVTRNDFEIQARPSLPLLSAGEVVRSPIYILGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X815</accession>
    <name>A0A6G0X815_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Formiminotransferase N-terminal subdomain domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_007219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X815"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012710"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005542">
        <property type="term" value="F:folic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.670">
        <property type="entry name" value="Formiminotransferase, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.990.10">
        <property type="entry name" value="Formiminotransferase, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037070">
        <property type="entry name" value="Formiminotransferase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012886">
        <property type="entry name" value="Formiminotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037064">
        <property type="entry name" value="Formiminotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022384">
        <property type="entry name" value="FormiminoTrfase_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051623">
        <property type="entry name" value="FTCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12234:SF1">
        <property type="entry name" value="FORMIMINOTRANSFERASE N-TERMINAL SUBDOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12234">
        <property type="entry name" value="FORMIMINOTRANSFERASE-CYCLODEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07837">
        <property type="entry name" value="FTCD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01222">
        <property type="entry name" value="FTCD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55116">
        <property type="entry name" value="Formiminotransferase domain of formiminotransferase-cyclodeaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formiminotransferase N-terminal subdomain" evidence="1">
        <location>
            <begin position="5"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0736196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="280" mass="30101" checksum="1C78A3AE1DD96C18" modified="2020-08-12" version="1">MTSRHLAIVYVSAGLHRATVEPLNAIALKQEAVLAHSFVDPIYNRTSFFFVGPNVAPSAAALASAALEQLDFSQHTGQHPALGAVDHVCFSPLGTTTLDETATQASRFLQTMTASQPHLPIYGYGHLTGHRLRDIRRRLGYFDMTASTALETLAQTLPATPSTFNSSSTWSPKHGVMCVGVVPFVLNFNMRCRSSDSKATVAKITASIRSKEVEALTLQHKEGAFEVACNLLQSSIVSPSDVLARARARAAQVGAEIVDSYTTGPTEDALLESYNAKRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X8A9</accession>
    <name>A0A6G0X8A9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_007261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X8A9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019394"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0736239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="184" mass="21043" checksum="FE97303339E08B84" modified="2020-08-12" version="1">MYRFFKSIFQSRSQSESNGSIIGNPCDLPPLSRRVLRSMQKTPLHLQCQYAYKACTNPRTHKKDGEIHKLCAVHRDRANSVQKIYAAKRRARAREERKQKIIQNKAAASTTTPSTLDRQTSATKEEPTQQTSALGDTLDAWTLEVLMSNPIIEPIMSPTPRDHSFSTEEYDILCNMLLKDELYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X8B4</accession>
    <name>A0A6G0X8B4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA damage-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_007328</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RSE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X8B4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017829"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001143">
        <property type="entry name" value="Pre-mRNA-splicing factor rse-1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000031">
        <property type="entry name" value="Splicing factor 3b subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="8">
        <location>
            <begin position="13"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="9">
        <location>
            <begin position="445"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="7">
        <location>
            <begin position="849"/>
            <end position="1168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0736308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1201" mass="133293" checksum="3AA0429AACAFA143" modified="2020-08-12" version="1">MHLMNITLQEGGAITNAVYGNFCGTKSQDIVVSGGTSIRLLQTQTPSDTTSLKQLQTIHSQEVFGVVRSLMPFRLTGGTKDFLVVGTDSGRITVLEFMVESSKWEVRHLETYGKTGCRRITPGQYLAADPKGRAIMIGAVEKQKLVYIMNRDASSRLTISSPLEAHRSHAIHFDIVGVDVGFENPIFAILEYDYSEHDDGTIPASEAVKSLVYYELDLGLNHVTRRWSEPVMKSANKLIAVPGGTDGPGGVLVCSEGWIVYKNERHPEVPCRIPQRARPVNTNVDVRSEVIIVAAATHKQRDLFFVIVQSELGDLFKVTLTYVNDQVSAVKVKFFDTLPPATALCITKTGYLFAASEASKHYLLQFQSIGDNDDTAEAHSFQDYVPSFTLRRLTNLALVESMDSLAPITQLLVDDLANEHTPQMYALCGRGNRSTLRVLRHGLSITEVACSPLPQIAKAVWCLKAHDTDVLHKYIVVSFDDNTLVLEVGESVEEVTNTGLTKEVGSLYVGLLADDSMVQIHRQGFNHVRQSHGVMQFKAPGKKVIEKCAANSRQVVLSMAGGTLIYFELNAAGELAEVGRNESLGEISSLDVGPVPEGRQRFPFLAVGSYDGNVRILSLDPNNLFNDQTLLALPGSHPHSLCFAQLQHEPHTDALGGHALFLTIGMENGVFQQSRIDPLTGKVMDTRTRFLGVKPVKLVRVQVQGKQAILGLSSRGWLSYFHGARRQLTPLSCEPLSYASAFLSEQCAEGVVAVAQDELKILTLDALGQVFNQQMVPLKHTPRQAIVHPVTRRLLILEADHNTLTAEQYASVGFETASFPLQEDEDEEEENHLLNYRPPIPVEPGHWMSCLRMIDPVTCETVLCHDFEPNERAMCMSTCVFHDRGGETFLIIGSIMNMKLHAGTKSEQAGFLRVYRLVEGTSMVLVHMTELDGIPYAMCEFQGRLLVSVGKILRIYDLGKKKMLRKCENRNFTSHLVKLTTAGSRIYASDNNQSFHFIRYRADDNQLVIFADDFVPRFISASTLLDYDTMAGGDKFGNVFVTRLPSEVSDEVDNPSGNRMLWDSHLLNGAPNKVEQICQFYVGETITSMLRTRLVPVGKEAIIYTTVMGRIGALIPFSSRVDVDFATHLEMYMRQEAPPLCGRDHLSFRSYFIPVKDVADGDLCDQFGMLSAEKQIKIAQDLDQTPMEVLKKLEDIRNGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X8Z8</accession>
    <name>A0A6G0X8Z8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_007531</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X8Z8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020081"/>
    <dbReference type="OrthoDB" id="68630at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0736521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="265" mass="29764" checksum="99E80B7F3E1D1E41" modified="2020-08-12" version="1">MDVLRSPSHEGTFGATPTAEETSATTKAKPTQSRMRRMLKQLFVLPTIRFALGAVFGATATVTICFFPFPKGKYFSFICAPIALAFAFLLDKYTNTSVCMVTTAIKVIQRKASFTTAWVVYLGMYFGASYIIDQFQHAIDTSPPKDRQYMELVVEKLYFAMNETVSSRLQQTTVVTAFFYGFDHALIRVVLHSMALIWLVLLPEMNPAIAMGFFGNTKALDGEDRARFWVNFVFLVVSCVVFAKVCELILRVIQAMTSKSKPKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X9K9</accession>
    <name>A0A6G0X9K9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_007134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000088">
        <property type="protein sequence ID" value="KAF0736686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X9K9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016936"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0736686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="264" mass="28286" checksum="7A29F1BC6B0D7C47" modified="2020-08-12" version="1">MEPTSVYPTTTEMDPLILSGDDIGGYATSSALCIPSELPLPAAVVHLNHQSVQAKHQQIGFTLQVVGGLSLSAMAVLVQAASSTLKVETILFWHCSIALGLNMLQKRFNMPLYSIDDDMRKFVHLYSALGYVVLALSFYVLADVPVSDAGVLLGSASIATSFAGCLWLRLGPPRQKLDWALASLPLVGLFFVEGPFCLLPSKDPVGLVHVGAIAISILSGGIWILLTFQLKELSPLHLMSHLLTVSTIASAIKAAFFTEAWLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X9T6</accession>
    <name>A0A6G0X9T6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_006987</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIF beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000087">
        <property type="protein sequence ID" value="KAF0736831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X9T6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017770"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000035">
        <property type="entry name" value="General transcription factor IIF subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003196">
        <property type="entry name" value="TFIIF_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040450">
        <property type="entry name" value="TFIIF_beta_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040504">
        <property type="entry name" value="TFIIF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011039">
        <property type="entry name" value="TFIIF_interaction"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02270">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17683">
        <property type="entry name" value="TFIIF_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50916">
        <property type="entry name" value="Rap30/74 interaction domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIF beta subunit N-terminal" evidence="8">
        <location>
            <begin position="21"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIF beta subunit HTH" evidence="7">
        <location>
            <begin position="183"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0736831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="251" mass="28477" checksum="D47E62329758F11A" modified="2020-08-12" version="1">MDDASDEEEFIEPVYLDLEGRELYLVKLPKELGYSWNTISDSEVVLGTLKMNKRDASGNRKGLLSVNPATLSEEIPLDYRTVLAPSALPLKVFSQDGSGRMAIEGKVTESCTLMPQPGALYKKQLGERYIKSMQKGTVVPLESTPKQVKGGITLKIPKPRESDDEEEDDGKFISKDLQNKKIKMDRDALKNVIFKQFEKRDFWPLKELNLHCHQPEAYLKEILKEICVYHKRGPNKSCYELQSHLKSAQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XAM6</accession>
    <name>A0A6G0XAM6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Prefoldin subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_006910</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000085">
        <property type="protein sequence ID" value="KAF0737106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XAM6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021114"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23165">
        <property type="entry name" value="Prefoldin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016661">
        <property type="entry name" value="PFDN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100:SF9">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016477">
        <property type="entry name" value="Prefoldin_subunit_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="79"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR016477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0737106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="127" mass="14597" checksum="E5C4EAA4501EF7F0" modified="2020-08-12" version="1">MLAPQQEVEVDVRKEDQEKINEFGRNNTRLAELRDELKALKSRLETLDDANTEIMMGSGENVQLFIGESFVEVSEEYAQEYLEAQTEKVNAKVDKLNAEEAKLETRQEALKKVLYGRFGQSINLEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XBH1</accession>
    <name>A0A6G0XBH1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SANT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_006531</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XBH1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021732"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051066">
        <property type="entry name" value="Trans_reg/Corepressor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16089">
        <property type="entry name" value="REST COREPRESSOR COREST PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16089:SF40">
        <property type="entry name" value="SUPPRESSOR OF ACTIVATED EGL-4 PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SANT" evidence="2">
        <location>
            <begin position="97"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="2">
        <location>
            <begin position="279"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0737363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="351" mass="39466" checksum="6D5AEAA9DFC71AA0" modified="2020-08-12" version="1">MAATEESTAQSLRLALQPKRSSKRTLDAVASSKVDAAKRGAAHAAAITRYLNAARALFSPVKHDDTWKSLENPFGFTSALDSTESLRHFKSPLRPPHVLDSWTPYQIALFELGISQFGKKFHMIQQLIPAKSTRDVVLFYYTWKKCGLDKATWGERDAAKDPFGMKRMKKEREAHGIVPTAYDLMSDEDDSTTLAVKQTSLRTQPRRKRSSSASAPPPMSPNPHVTQMKVQETTTEFFAAVRELYAATAPPSVTLDEFDLRLPQKLTLVPMLSVLRPPHVLDAWSPWELGVFECGLRLHGKQFHAISNLLPSKTTQDVVALYYVWKVHSPVYVEMKRSWPPSIFGRFDPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XC10</accession>
    <name>A0A6G0XC10_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_006328</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000083">
        <property type="protein sequence ID" value="KAF0737661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XC10"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0737661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="130" mass="15135" checksum="E214B1732223F178" modified="2020-08-12" version="1">MSQDIFDDFYERMMRRTAPAVIVIESSSDEENEESISTAIVIPENRAASTSYPVYLQRNRHDRKARKRSERRMVSIPQRYSRRDALAMHKLDWIRHQAFAPLSSQRMNIFQSISFRSQAPSVVPPPPPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XCQ9</accession>
    <name>A0A6G0XCQ9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_005942</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DDI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0737946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XCQ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017176"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05483">
        <property type="entry name" value="retropepsin_like_bacteria"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034122">
        <property type="entry name" value="Retropepsin-like_bacterial"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12917">
        <property type="entry name" value="ASPARTYL PROTEASE DDI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12917:SF1">
        <property type="entry name" value="AT13091P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13650">
        <property type="entry name" value="Asp_protease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A2" evidence="6">
        <location>
            <begin position="204"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="447"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="476"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0737946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="519" mass="57568" checksum="EF1DE3463FA60B98" modified="2020-08-12" version="1">MAKLAAAAIDSVRAEIFALGLNNHEARREVCRDCSKTNFKLDGLCWSTVFCTLYQRMGHPEINCFKACQLCTTPHHKADPCPTRQQAAELKEFLQGLDIPDMPSLDCLNFVKEAIKNEDRTKDRRDPDAANHIGFLKVPPVTKNTSNLAGKPFVFYSAVDCATLSGEYGLKEGEHFGHWQDTTFIENDMNRQAFLNAQIMDQAVVVLADTGANMSIIHPSIVKKLGMKVDTTKTTDISGLGGAAVVNTQGIVHIKLTIGRGLVYVFPIVVCDFGNTGFDAILGMDFLFRAGVMVDASRRELNLPEGEYVELHDQPVRYSRGYMNYVRLNRDVSILPGGSVVVPLPKLREGMPETLEYWVHRDVRWITTALNSENKPAAYKVTNVSERNVFLSAHTAVGAISAQGERPLDRPMVRTSSLRYQAWKAEAWEGSYPDDYRARLDEAAAELADDSSWKEPRPPSPRHLLTADGELRETCKVDDESSEGGRQPFADQAPGVPLSLTEAAKSKTPAVFCYHACHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XD03</accession>
    <name>A0A6G0XD03_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_005924</name>
        <name evidence="10" type="ORF">Ae201684_005926</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0737928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0737930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XD03"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011491"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000003">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="8">
        <location>
            <begin position="294"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0737928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0737930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="789" mass="89059" checksum="9D5E05C60B8B9269" modified="2020-08-12" version="1">MKAAFYDDDEAIPHVNAAMRFASKGSKESSIKNQSTKDTLFGVSLEVEVALLGEGGTKLFVTALLDSGCSHSTVLRTAVPPIYTMRPSEITFSMPNGSHSSTREAVTMPIILHSLTPPRSCAVNFQVAEKLIYTIILGVDFLVDQQVVLDFKSKIVIWDGVEFSLVGNQPIRSLGIRNGHQPFRSNQLEYQPIRSASLLEAAEDRWMRILGVMNSPVALEKIVCRDLLTNTQVQSALDLLERYKTLFSGAIGTIKLPPYVIPLKLDAVPHVCHPYPIPESHMASVKAEIQRLVGLGVLVPDIQSPWASPPFFIPKKDGSMRLISDFRKLNAQIIRKYFPLPKIPVTMRSMRYKAFKTVIDLVMGYFGRVLAEENRECTAIILPFGKYVYKRLPMGLASSSDEFHSTMLHLLGDLDYVLVYLDDIMVVSDNFNDHLVHLDVVFARLCEYGMMVNPQKCRIAAPEVEYLGYMLTPDGIRPIESKVDAIIKIAPPKTRRQLKRFLGMINYYRDMLPQRAKTLAGLNKLTSPNVPFKWTHQHHDEFEQAKRLIAERTLLAYPDFTKPFHVYTDASKLAMGGYIEQDGKPIAFWFKTTSPAQANYAANKLELLSIVCLLTEFRGILLGHQLIIHTDHKNLLYSKMGNAQMHRWRLLIEEFGPRISYVPGKSNVMADSLSRLKTMDQRRPESICALTFDPTSIFPLDLATIADHQAKDPDIVDDMQLRRQEISGHIVFTTPDGKIRLPKSLPRAVFDTYHSWLLHPGSNSALNSLKEIFHWPSMSKNVSDWSKSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XDI8</accession>
    <name>A0A6G0XDI8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FCH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_005844</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000077">
        <property type="protein sequence ID" value="KAF0738286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XDI8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012118"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043226">
        <property type="term" value="C:organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF7">
        <property type="entry name" value="NOSTRIN, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="420"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="164"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0738286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="694" mass="78624" checksum="9BD6C70D4E5CA4A7" modified="2020-08-12" version="1">METKQPEATSCSLESLKLRLDVVEKKTVDGAQSVKTIMTNLRELASAEEKHGKTHQKIHDMLQYVPHTNENVLTGLKNWHAAMLKNSNELTYVKRQFAASLVSHVVNPLQEHLDQYRRDTRKIFYDLRASYESLVNKQHQVATFKEKYYKACRVAENAIRHRNATKEKLENENRKTDANSSAPVDIPVDPRKLEALEALNRKVKACLDESDNAKEAYVASDAECVSERIKHNEFVVSTLRKLEEIEIQREDHLQNQVFFWLASMYQDTFSSTANLYKTHLTTSEGILKSALDQIAQFSEGSLTLDASLGFVTEQMANDTDTLAKLCDVFSQMKMTFEAHAKRLQQLTANFSWTMSSMEGPLLVKAWEKISTAIQVLAHIHDEYSITLSGFVTSQWKDLKAHQMASKRQILSMVQDIHLKRQGVENNERDACQRYNQAKKELQSKQSQIEAVEREVVEEAKSPEKDKGGVSLVSLGWKDPAKIRLVKLKRQHQEFEETDMATATKQYSFARSASGNFHSTYNSLVTAVHTEFIKAQSHSISSLVNILTAWQSAVSKAESCQLQILHDVFESIEAIRPKQDVQMVVATQLAAMPMAVTEPSHAPVEFFKSELIENELKPPPPPVADHSDEKLDAKTATLLPAHQIEFGFVCLCLLGILVVHLVHQKLRGELLQVEAMLGEQQASVDYLDMMLQQFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XE91</accession>
    <name>A0A6G0XE91_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WRKY transcription factor 19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_005636</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000073">
        <property type="protein sequence ID" value="KAF0738524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XE91"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012156"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827:SF1">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0738524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="19665" checksum="0A488B98C93A61ED" modified="2020-08-12" version="1">MTQCMFNGCTLQVQEGSTKCSAHRNRTKCDILNCPNQAYTRGVCVRHGAKRNCAVSQCQLNRRFGSYCSKHADATQKKQCETEGCKNQAHARGKCVRHGGGHLCKADGCHRHARLGGFCSRHSVYVTISRMQLGAPKAKPDHLDLAILQDLVSDVSATSTTWLSESESQQPVKLMWTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XEK2</accession>
    <name>A0A6G0XEK2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_005597</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000071">
        <property type="protein sequence ID" value="KAF0738670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XEK2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014564"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052061">
        <property type="entry name" value="PTE-AB_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260:SF1">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0738670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="26110" checksum="E1EDDF56695C0D07" modified="2020-08-12" version="1">MLFCKHCIDIVHVLLKRLKLETIASTRRAEVILRQLATKPPGTPFFSTPDKATHEISVQVPSKIEEIIADSNYVALTRDSLWNNPNFPWPRSNVEDDFFFPNVHESGKYEAIQVYGHKDRTKVVAWVHFGRQLCGPKDITHGGCIAAVFDELFISSLIWMANRPGFTATMTVNYKRRMMGSKSALFYIDLEKIEGTKVFLKATLQDSEGVEYSNATAVLVTPNNFGKKKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XEP6</accession>
    <name>A0A6G0XEP6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_005569</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000071">
        <property type="protein sequence ID" value="KAF0738641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XEP6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016539"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0738641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="159" mass="18795" checksum="4AAC745477575661" modified="2020-08-12" version="1">MIAPSTDGFLNLKDLLTLSMVSRSFYYTMNHDYWEKIAQAPMFESMYKVAAFAKMKPRQRAVRIMERRLCTHCRQVQPYDIRPLRPRLEAFMVCDVCAELPPFAEIRYKDVMKQYGLKRKQLEAVPSRTEKISRGHRGLFKLKDILELVEKVRESTNDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XF11</accession>
    <name>A0A6G0XF11_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_005354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000070">
        <property type="protein sequence ID" value="KAF0738735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XF11"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000295"/>
    <dbReference type="OrthoDB" id="185175at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000286">
        <property type="entry name" value="PH-protein kinase domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051707">
        <property type="entry name" value="PI-Interact_SigTrans_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336:SF8">
        <property type="entry name" value="PROTEIN OPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336">
        <property type="entry name" value="TANDEM PH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="9"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0738735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="121" mass="13860" checksum="0BDEC665A06505DA" modified="2020-08-12" version="1">METSYDLSNPDYEGELTKRSVWLKEWRPRYFVLKGNKLYFSRVKGESPHGVIDLAECLTVKSAEEKTNKRYCFEVATPESTYYMHAESEKQKDEWIGAIGRAIVKFSSSFTGEEGADDGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XF36</accession>
    <name>A0A6G0XF36_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_005409</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000070">
        <property type="protein sequence ID" value="KAF0738797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017560"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058033">
        <property type="entry name" value="ARM_TBCD_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033162">
        <property type="entry name" value="TBCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022577">
        <property type="entry name" value="TBCD_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658">
        <property type="entry name" value="BETA-TUBULIN COFACTOR D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23579">
        <property type="entry name" value="ARM_TBCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25767">
        <property type="entry name" value="ARM_TBCD_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12612">
        <property type="entry name" value="TFCD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin-folding cofactor D ARM repeats" evidence="4">
        <location>
            <begin position="319"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin-folding cofactor D C-terminal" evidence="3">
        <location>
            <begin position="1005"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1281"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1285"/>
            <end position="1303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0738797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1310" mass="147130" checksum="F957D40B4456ED72" modified="2020-08-12" version="1">MDIVIADNEVPDDSTNRDGTAANEALQVDHRLVDILHVDVYTEATVESFRSLIEPFQEQGQLLDPILRSLVLPIVERIQNIIETTRSSSEVTDGSFPFQTLAIDQRIQLHRSSQVLYLLCKVRGYKTIIKLLPHDVAEFEPVLQLLQSQDRDDFITWEIRYVLLLWLSILALVPFDLKTIDSSLNGEEDNAESIVIVANITSICKNYLEDSGPTQQAAALCLARLLSRPDMEQQYLQGFINYVTHEFESFCSSHEATPTEVRIRQYKITGIMQTLSYICKFTPREKHIVLMGNYFHHVINVLETIRALDTDVTVSSTLHRKLGTKLLQRMGLLYLRPKVMTWRYSRGLRSLESNLNIKSVANQIPLQEEEDDDDLEVPEELEQVVDMLLCGLRDRDTIVRWSSAKGIGRITARLPFEFADDIVMSVLELFSTSENDAAWHGASLAVAELSRRCVLLPERLPEAVRVIGLALMYDVRRGAHSIGAHVRDAACYACWSFARAYEPALFLPYLKSTLAPIMLTLCAFDRELNCRRAAAAAFQESVGRQGLANFPHGIDLLTKADYFTLASVSHAYLNVSCHIGKYPEYRYSIMDHLASIKVFHWDANIRVLASKALGLLSPFDVSYSLSSILPQLLIASVSTTAEVIVRHGATLALGEIVLHIASVPAFISGETMRRIKVIPIEMDKNRLYRGRGGEMVRFAVCKLIQTISTVGWPLTPLLVKKYMATLEECIKHPNDSVRNSAISAYEVLAKRYLLKLLESYENQLYIEALVPRFLTQVKEKSVLNPNVAIRRGYLRALGVTPFAILKPHVESTIDLMILAAVSSLHTPDEQDAESRVAAILALVDFSSKLRPQMTSELFLRILEALFKCANEDYAMDERGDVGSWVRKEAMQGIHSIFTCYAQPLETDTPLRTVSVNGFGTGKLLEIRHYKKEMVYVQYEKPAMGYYYFPPNGIGIFCADRVSDSQCSGMFSLPDLSTRLISSPSPGVASEISVPPALISRFCFILVKQLSEKLDSIRSVAGSILYELFSKSDSTEGIPDLPTLSSTLKPTINWNMAHDTFPVVVQLLNSPAYMESVIEGLVISVGGLTESVVKASKGSLLAWLKERHLQNNLKAVSQFAFHCVSLFQKHTKDDRVITPLMKTIAYCLEEGVFDFLHRDGDVFGNAIYEAVRTEITKSSDMHKISAGLSVLLGLLPSQENVEKRTFRGLCVCLGHRFPKVRKLTAEKLYTRLILHDDLMKKHEMDTILSILSETAWDADINQARRSRDNLIDILGFEKVEKRTSGNDKSSTSNASSEKSNSYKSLVREMGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XFL0</accession>
    <name>A0A6G0XFL0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-reducing end alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="4">3.2.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ae201684_005200</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 62 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="4"/>
    <dbReference type="EMBL" id="VJMJ01000067">
        <property type="protein sequence ID" value="KAF0739012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XFL0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018584"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005193">
        <property type="entry name" value="GH62_arabinosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40631">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE AXHA-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40631:SF1">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE AXHA-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03664">
        <property type="entry name" value="Glyco_hydro_62"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 13" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026248783" description="non-reducing end alpha-L-arabinofuranosidase" evidence="13">
        <location>
            <begin position="17"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="14">
        <location>
            <begin position="16"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="58"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF0739012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="375" mass="39725" checksum="C0EC0C7B3C49B8BB" modified="2020-08-12" version="1">MKVAIVSTFLAGAAYAQSGAWQQCGCNGYTGSTTCVAGYTCTVQSQWYSQCTPSSGGTPTTAKPSSSPTVAPSNAPSTSSPSSGGGFCDLPKAPKWTSTGALANPKNGWVSLKDFTNVVYNGKHIVYGSVYTGSGYASTAFAPFTNWSDMATATQYTMPFSAPAPTLFYSVPRASGTDPTNVNSWSAEKPLFTGANPSGSPTGFLDQTIIADDKNIYLFFAADNGSIYKSSMPIGNFPGSFGSSYTTVMSDTRANLNEAVQVYKLQGQNKYLMIVEAFGSQGDYFRSFTAPTLDGPWTVHAGTEPGFAGKANSGVTWTNWISHGDLVRTNPDETFTVDPCNLQFLYQGKDPSSNAAYDLLPFKPAVLTLQNPVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XH27</accession>
    <name>A0A6G0XH27_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_004995</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000064">
        <property type="protein sequence ID" value="KAF0739429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XH27"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017049"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098855">
        <property type="term" value="C:HCN channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003254">
        <property type="term" value="P:regulation of membrane depolarization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035725">
        <property type="term" value="P:sodium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.630">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051413">
        <property type="entry name" value="K/Na_HCN_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45689:SF13">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45689">
        <property type="entry name" value="I[[H]] CHANNEL, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="282"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="9">
        <location>
            <begin position="387"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="581"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="631"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="581"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0739429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="751" mass="85682" checksum="0A8E9F8105838329" modified="2020-08-12" version="1">MFRFSWKALVPLHVSQTFSWHAAQSISTLVKQLDNRDNDLDIFHTIVKKSRTMIHPNSNFRRFWDICTAINVIIVCVLMPMDLAFDAYMASLSWIESLETFLDFYFIMDMVLSFRTGHIACGEVVMEPKQVASHYLKTWFIVDLVSNFPFKVVMQNASNPKSVKFLKLQKIPKLLRFTRLLKYMRQYAKYYKFVLTSCVILLSLHAFSCVWVYMYFSCDDLTDSLQATLSCKDAAFQITPIYLEALTNVVILYMGYGQASTYLHISPVLYTPQDKSTPGSYLLCLGIILFGISTMSIMLGNVISIIISWDQQSAIFRNRMDVISAEMRHYDIPLELQRRVRRNYDYLWINQRAYSEMSILNQPGISQPTRTNIALHLYRDLIESVPYFAGEDQKFLGRVCLALRTAVFLPGDIIIEQGDTGREMFFVRRGIVQVELPSGPPHIELKDGDFFGETALVVDVRRTNTVRAVSICDLNELSKAAFDDILAEFPEFFEKIKRVVIERQLNNMNIKSEKDKALIKAEITDVVNQTADRRINDMSSPYWQVLNAKRVGNRLKTISDKVRMAQQQNPRQSTVIYRPRGRIRRRSAVPKRNLSKKSMASPSSMRRLLKDIHVPTDKHGAIVDAIATLNYGHPQKPAPSPPLLEEEEAPTPPRAQSHPLEPGNRREAAAIPDTSPPLVSLSARLAEIEKSTVLLPLFLKAFEDAVQRVVTDTTCPAMVSQNSQLSANHTNEVQDQCLACSKAMNTNRPYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XIM0</accession>
    <name>A0A6G0XIM0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleotide exchange factor Fes1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_004495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000055">
        <property type="protein sequence ID" value="KAF0740054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XIM0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004958"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050693">
        <property type="entry name" value="Hsp70_NEF-Inhibitors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013918">
        <property type="entry name" value="Nucleotide_exch_fac_Fes1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316:SF18">
        <property type="entry name" value="HSP70-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316">
        <property type="entry name" value="PROTEIN FOLDING REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08609">
        <property type="entry name" value="Fes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nucleotide exchange factor Fes1" evidence="2">
        <location>
            <begin position="9"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0740054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="325" mass="36265" checksum="96CAEA5E75AF9D37" modified="2020-08-12" version="1">MADPNKWLGLLRWSMQQQDGTAPSEFKAMDPKDKEWLERVMKECVIDEIERMHQIIRVWSGEDPRTVLPKLVSDPPANPFTEEEIEDYKEALLDEMLTRIDQIDNAQTFVKIGGLTSLLSLFDNPHATIRAGAAEVFATCAQNNPPVQKAGLDAHVLEALCKLARDENATCQVKAILGISCMIRSLDKTAELWFVQKCDGLQLLQTCLTKDDLRLQRKALFLLRYLANADLANAQQLLDQGQYISACKQFIGKDDVDLNESSLQALADFASCGPAFKAACKKAQLVPLVQARIAAIDALQGEEVEFAQEEKSFAQLLLENLDVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XIY4</accession>
    <name>A0A6G0XIY4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_004252</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000053">
        <property type="protein sequence ID" value="KAF0740248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XIY4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016758"/>
    <dbReference type="OrthoDB" id="78462at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0740248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="169" mass="18835" checksum="95EE84398F021A49" modified="2020-08-12" version="1">MEENPKAEAVHAVIAFVKRERPRALTKEERLDILMLCAQLKLAGEKYVSVKVAKLLGRSKSVVQSVWAEFTATKGVSVQTAAGNRSNHATRFPRTPAVINLVIEFVRQRQGLGLTTEVTDIMQCLVENRVLQVDHRDSKSVQASLRAISRFLRTINNIKATEGKLSLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJ31</accession>
    <name>A0A6G0XJ31_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_004101</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000052">
        <property type="protein sequence ID" value="KAF0740362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJ31"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019457"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0740362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="83" mass="9663" checksum="1246CE7C2E19EAEC" modified="2020-08-12" version="1">MSTIQARIHTILEKCSWTTPNAAPANTFECDTDEEIDDLMFHREDRDPNAGHNKKNETLLFRQNTLDDFLFYRSDRATEAEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJ61</accession>
    <name>A0A6G0XJ61_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_004257</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000053">
        <property type="protein sequence ID" value="KAF0740254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJ61"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016753"/>
    <dbReference type="OrthoDB" id="446890at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029760">
        <property type="entry name" value="GPX_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592:SF78">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000303">
        <property type="entry name" value="Glutathion_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00763">
        <property type="entry name" value="GLUTATHIONE_PEROXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 5" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026233302" description="Glutathione peroxidase" evidence="6">
        <location>
            <begin position="19"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000303-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0740254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="195" mass="22837" checksum="A14F465A0BE37815" modified="2020-08-12" version="1">MRSLIVATLVALLALVVAETEKDIYHFMATKDNKDYPLANYDHTPVMLIVNVASECGFTDSNYRELQRLQDEYHVFGFEVLAFPCNQFGEQEPGTYDQIINFAQTKYNVNFNIFDKIDVNGPNSHPLYRWLKSSLDNKPVQWNFEKFIVVDGYPWKRYAYNVDFETLEEDILYALAHESEFHHPDNDPLEDHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XKW3</accession>
    <name>A0A6G0XKW3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DDHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_003630</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000041">
        <property type="protein sequence ID" value="KAF0741058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XKW3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005648"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004177">
        <property type="entry name" value="DDHD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058055">
        <property type="entry name" value="PA-PLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057634">
        <property type="entry name" value="PAH_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509:SF10">
        <property type="entry name" value="LD21067P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509">
        <property type="entry name" value="PA-PL1 PHOSPHOLIPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02862">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23202">
        <property type="entry name" value="PAH_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01127">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51043">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDHD" evidence="4">
        <location>
            <begin position="434"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="762"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="3">
        <location>
            <begin position="880"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0741058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="997" mass="111801" checksum="AFAB91C5C7BD3F82" modified="2020-08-12" version="1">MTAAVVAAGLVEEYDKWMHDIQTCLSIAHKVSATIEHPTTKLEISTVTAAAESLETCSAAVSKALSFLHNLLDSFDTKSDGTSGDPTISTTGIYSDHPQESADESEDDMTETGDEDDETDDDDDDEIDLSDLPEIDPVYGEEAEKLNGVVIDRIEAALNDDARFDAFRLQAMDFGTGKQSADEFYMYLETQMTDQMISEFILDFARLLANPEQRTSLLISHVRAQRQRAKSKSNHRKASMSSSVSGGEETESFNFPSELHLDTINHLMFVIHGIGRHGDFKEGDQIENPSAPWATGSNQAFRDMFRAMQESHFKEIPIALEIQSIEWHEELHDPTGVDAVFDIICPEGSQGIRQFNKDAFMDILYYLSPNYGQIVVNSVTEQLNTKYKVFMDEHPGWNGQISIFAHSLGTVITYDILTHPAGSVAKNGVKFSGLDFDVENFFAAGSPVPVMILSRGDLDLKDGKFTPGIALPKCNHYYNIYHPIDPIAYRIEPLMHPDMHDKPPVQLIQAHHCRNMPFSKMQEMWERITAPAPGFTSPRIDYVMRRRSREGVIEMAYAAASHSACWESEDVVMFTLMQICRPVVDILRRYMSAQRPLPSLCPRGLVPITPHSKVHVATTVLARDRATGVWQTRTVVMDHKRVYLASNVDDVACRKKWVIALSKKMIVELGDDAFTLKVAPEQKAPKSPALNLFGATPPSQAGQATQILRANTTELRDEWLSAIKAAVDALSHIVAPLIPISTTGLELPTGTSLDYFGALKTSILQFKTLKAKSWYESQGWTTRWFVLTDTSLECYEGCPNLLRLVQFPVYKATVLAYPKRCLIRIVTKTGTTLDFKVKDSRTFDVWIQGLEQVDRCAIKLQEDVTEHSALGVSLDSQLPATHRLSVDKYFVLNDDKGSYAAFQIRIQNGGQTILRRYSAFRELHRQLRLIFPHEQMPSLPPTRLWGKFDPSYLSTKCSLLNTYLGNIETMCTNNHSAKTIFQQFLDVDKASPTYGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XL96</accession>
    <name>A0A6G0XL96_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bifunctional GlmU protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_003824</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000042">
        <property type="protein sequence ID" value="KAF0740939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XL96"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016203"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42883">
        <property type="entry name" value="GLUCOSE-1-PHOSPHATE THYMIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42883:SF2">
        <property type="entry name" value="THYMIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0740939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="354" mass="39208" checksum="697F62DDF769F1AB" modified="2020-08-12" version="1">MTEHASVWIQAVCCVLTSCLTLYYVHQLHASRNEESREKDGRRNVAVATTSAPVAKPVKLNTLPLDEVPLVLRPSYYFSHLHEFKHYDLFHHATNVFDVLDNLHAYCEKWLEAYTPEKTSKAKTTIKGGKVGDVSLTCPDPAIASACTLLNYETKKPRRLCLDDGVRIMGGVLDVSEGSIYLGKNVVMEPNVYIKGPAIIGDNTVLRFGTYIRGDVIIGKHCVIRCEIKHALIMDKAELCHPGYCGDSLCGYKSHFANQVSTANLNLLSASTIYVQVNDVVYDTGRRKIGVILGDFSQLGCSVVTDPCTLVGMKTAVYPLTRVNKGFYGPSEIIKNKPMEHGVIERTKLRVAQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XLH0</accession>
    <name>A0A6G0XLH0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit delta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_003685</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000041">
        <property type="protein sequence ID" value="KAF0741120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XLH0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006906"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10233">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10233:SF14">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="48"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="429"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0741120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="504" mass="56004" checksum="7840F7783004CB96" modified="2020-08-12" version="1">MSDPSDLKDIEKMLDKKEAKNKGKKSPSATLSKPDISAGMEKLSLAAEDDKAARRDKMANQTFEKKPKLSKEERRAQQEAQRAAKAAGNAKPAATKPVAGPAPPTARLQYDDPKKVAKYSKSSVIQRTQAQKQVAMFSHLPQFERESSLSLNVGFSKAEIHPAILSLGLKYAEGKIAGGNARCVAMLTAFQQVIKDYQCPPDKVLRRDLDKTLRPLIQFLIDCRPHSIGMGNAIRYVRNVIATLDPAKGDDDAKQFILEEIDQYIQTRIVMSMTAVSKFACSKIVDGDVILTYARADVIEMLLKQAHDDKIKFRVLVVDSRPHFEGKKLIRALAEHGVPCTYLQINALSYVMKEVTKVFLGATAIMSNGAAVARVGTALCAMTAHEFNVPVLFCCETYKFSDRVQLDSFTHNELRDPDELVNSYSTDVNTDRLNRPKAEGSSSSHVLADWRDLPNLKLLNLVYDLTPMEYVMVVVTEIGMIPPTSIPAIIREYRKETNNDEANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XNW8</accession>
    <name>A0A6G0XNW8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_002760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000030">
        <property type="protein sequence ID" value="KAF0742085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XNW8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014668"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA" evidence="1">
        <location>
            <begin position="147"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0742085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="474" mass="50716" checksum="415AD1FEFE2D71E3" modified="2020-08-12" version="1">MQCGDGKVFEFVVLVNTSEPLGMLLSEKLTVLSFVQDNDGRERVIEATGLVEIGDMLVGVNERTTAGMPLVSVVEWIRLATLPKKLTFRALNATRCVPSTSSTTEILDIIDLTINFVEVSQDTGTTLTQKFYALASAFGERPACYIYPLVLADPIHACAPMEKNITGSYVVAESTTQCSAHQQALIVGQAGGVGIVLAQYDGKKVETIQSPPGYKGTIPTPVVMVSRAAALIIAEMVVTEATSIRVIVTRECEEEYKDITAVPMTVQEKQAELAEATSGDLAIAAVDGISTAEFVKLATSPPLPLGKQPVLVFSGNLCLVSQLDASIKSNMFVLAKLRSECSVEMQIQRVVDSGAAGVLLCVPSSIPSSITIVQVSTTAIAAVFVSLATFDSISLKAEDGAVSVQFEANNAYLQQYEELQAVMEPSMWPAGARSRHVLYHRLKKAMADSDHKLEALAQCYHAAEAHYTASVDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XPM8</accession>
    <name>A0A6G0XPM8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase C51 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_002572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000027">
        <property type="protein sequence ID" value="KAF0742476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XPM8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009376"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.10">
        <property type="entry name" value="endopeptidase domain like (from Nostoc punctiforme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007921">
        <property type="entry name" value="CHAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051705">
        <property type="entry name" value="Gsp_Synthetase/Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30094">
        <property type="entry name" value="BIFUNCTIONAL GLUTATHIONYLSPERMIDINE SYNTHETASE/AMIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30094:SF0">
        <property type="entry name" value="BIFUNCTIONAL GLUTATHIONYLSPERMIDINE SYNTHETASE_AMIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05257">
        <property type="entry name" value="CHAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50911">
        <property type="entry name" value="CHAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C51" evidence="1">
        <location>
            <begin position="70"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0742476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="230" mass="25914" checksum="D606AE1C46A4A761" modified="2020-08-12" version="1">MSRRRRRTLSLGNFLSLLQRQSTANMPPHRQETPMLALECFSSLNAGVEHCRFGTLLGVFEGVEVRSCRLPPTLNALDMPPSYHDGIFTGIQWQCVELARRYCLIHFDVVFDPVDMAYQMFESAVFRNVHTLRPVSAARFSNGATTPPKKGSLLIWNCSGEYKITGHVAVVVAVTDTHVDIVEQNVIHSVWESGQQYSRRLALSTADDGSYTIQPFYPDEELLGWITLAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XR68</accession>
    <name>A0A6G0XR68_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LTD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_002223</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000023">
        <property type="protein sequence ID" value="KAF0742821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XR68"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010062"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1260">
        <property type="entry name" value="Lamin Tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001322">
        <property type="entry name" value="Lamin_tail_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036415">
        <property type="entry name" value="Lamin_tail_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00932">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74853">
        <property type="entry name" value="Lamin A/C globular tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51841">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="LTD" evidence="2">
        <location>
            <begin position="19"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0742821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="407" mass="45911" checksum="19601F8CD979C608" modified="2020-08-12" version="1">MPYATLRRVLVPPLDRRVLRGTMQISNATAMQQLYISRVDIEAQWVVISNPSMKNINLTHYTLTDETATRVFHFPKGYILQSGEEVTVWCVPGTNGFNSNNLLDPYLLWTSLDGALSSSPFFLRSQHVHEVLLVDGYLTEVASLQLTSNGQKTFRVNSATPQPLSYPYLNSFHFERSHGVYIFSRYWGVVSDPAYSAHFAAVAFTPVIEVARILLMYCLLAQVYLDPTGLNPLLLLLAGACDMASRFGSLYIKDGQLATFLSFSAFTVDQFQLMVIYQSLSVLYPSVQGLYSTLLTVELTLNLISLAGTPAHFFTRRRAWHRIYRLTESIIYRFPTFVTTCYVGKELFFFLLHLKAASPLFPPLVISVVLYLCIPLVVLSTTMTISRGISIAVHLLTFHTSRKQKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XRA7</accession>
    <name>A0A6G0XRA7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Small nuclear ribonucleoprotein Sm D2</fullName>
            <shortName evidence="10">Sm-D2</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">snRNP core protein D2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_002257</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the snRNP core protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000023">
        <property type="protein sequence ID" value="KAF0742860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XRA7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013646"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030532">
        <property type="term" value="C:small nuclear ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01720">
        <property type="entry name" value="Sm_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000069">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027248">
        <property type="entry name" value="Sm_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12777">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="22"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0742860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="106" mass="12145" checksum="30A1766568CB7984" modified="2020-08-12" version="1">MATIDDKRGTKEEEEEFLTGPLSVLMQSVKNNSQVLINVRNNHKLLARVKAFDRHCNMVLENVKEMWTEVPKATKGKGKPKNVERFISKMFLRGDSVILVLRNPHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XRV7</accession>
    <name>A0A6G0XRV7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_001988</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN7/EIF3M family. CSN7 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000020">
        <property type="protein sequence ID" value="KAF0743194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XRV7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011768"/>
    <dbReference type="OrthoDB" id="10265275at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045237">
        <property type="entry name" value="COPS7/eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350:SF5">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22061">
        <property type="entry name" value="CSN7_HB_subdom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="226"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0743194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="268" mass="29747" checksum="228BDC56F7BEFED8" modified="2020-08-12" version="1">MVAADDGSLEQFTLLAKTARGRACVALIQQVLSNKKLFVFGELLDMPNVKALAESDQADLQGHARLLAIFAHGRYLDYVRQKEDPNLHIPELNPAQALKLRKLTVVSLCQEHKLVPYRILMGELQIGSVREVEDIVIETIYSGLVEGKLDQKNERFESSYAAGRDVQPTDIDAMIERLTQWQEDAKVACRQIETILSNATLQEEQEAQLDAAIKKTVSSVRLQAKDRPVGSDLDPELMWGDGPAGGGYPRSSGKRRMGPATTRKVPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XRW8</accession>
    <name>A0A6G0XRW8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_002172</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Folate-biopterin transporter (TC 2.A.71) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000022">
        <property type="protein sequence ID" value="KAF0743115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XRW8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009956"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039309">
        <property type="entry name" value="BT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585">
        <property type="entry name" value="FOLATE-BIOPTERIN TRANSPORTER 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585:SF5">
        <property type="entry name" value="RNA-BINDING S4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03092">
        <property type="entry name" value="BT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0743115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="23348" checksum="EC2F63C5383D5C0B" modified="2020-08-12" version="1">MNNKAQAPLELQERVSYLSADRTKADADGNYVDAKTPNDLEDGALREGGAPVYTSPEVLALLSQYFAVGLLYGSLPYVPYNVLVQYFHLTGTQYTSAKALISLGWSLKVFVGLLSDVCPIMGYRRKSYMLVGWFCAATILLILGCMDHGPPYDKTLPDPKNQPFNIDVNSKGSTIGLLCALATISYIFADVPADAMVVEYVNVNLNTCVAVCKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XS03</accession>
    <name>A0A6G0XS03_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Microsomal glutathione S-transferase 1</fullName>
            <ecNumber evidence="5">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Ae201684_002195</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:16438"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotrimer; The trimer binds only one molecule of glutathione.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MAPEG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="5"/>
    <dbReference type="EMBL" id="VJMJ01000022">
        <property type="protein sequence ID" value="KAF0743140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XS03"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015838"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040162">
        <property type="entry name" value="MGST1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10689">
        <property type="entry name" value="MICROSOMAL GLUTATHIONE S-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10689:SF6">
        <property type="entry name" value="MICROSOMAL GLUTATHIONE S-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00039397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF0743140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="173" mass="18801" checksum="8C5317BD2843314E" modified="2020-08-12" version="1">MSKGLDTKVLVGATGVLAIKLYATLMIQGSKRFAAGTRPPEDQILTKFNPTNQRQAYGIFDEAADAKKNDDKKAINARPSVHAVQVDIRWDRIVRNDLENIPIGLLTAWAAVNSGGNVAVNVGAISAFTLFRILHTIAYAKELQPHRARFWSIGVLSVLTLIGNSAFGLISNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XSQ7</accession>
    <name>A0A6G0XSQ7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_001770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000013">
        <property type="protein sequence ID" value="KAF0743629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XSQ7"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026259066" description="Secreted protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0743629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="138" mass="15843" checksum="878A4E73D3BE7078" modified="2020-08-12" version="1">MWLRSTFLLSSITTLVPASGNSWFFRFSMDEQYIRRAFHRKRKPWILDIKKVFIACNVFQEEVTSIKQILQSLLQVRHVAISLTFVNLRNVRNPQKPTTEPSTGSLTSGSFVVKRIFLAIRSCLSALSLENEYAEASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XTQ4</accession>
    <name>A0A6G0XTQ4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GOST seven transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_001633</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XTQ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000784"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053937">
        <property type="entry name" value="GOST_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009637">
        <property type="entry name" value="GPR107/GPR108-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229:SF1">
        <property type="entry name" value="GH17801P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229">
        <property type="entry name" value="LUNG SEVEN TRANSMEMBRANE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06814">
        <property type="entry name" value="GOST_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026028229" description="GOST seven transmembrane domain-containing protein" evidence="7">
        <location>
            <begin position="29"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="GOST seven transmembrane" evidence="8">
        <location>
            <begin position="189"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0743994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="481" mass="52949" checksum="EE96072D3B85CA2B" modified="2020-08-12" version="1">MTSTRRSVALSLWIVAAVVQASIHVVQGPSVGWRATERMFANPPGKNGSIVRVDFNATPIDPPSSDVDYAVVVAIFDLVNGSVVPGDYCSMDYTSLNMTDHIVGRVFSSDAANNNAVRGSEEFVVQHSGSQVVVLATCTRPKLIIESFFNESTLDIPYEDFGLETVFNITGAIAFKNSYGYLPGLMWGLLPFSGGLSLAYIMSLLLFVVLVICNRPSLIRLHYFILVVLVLMTIETVLWFVTYWQLNATGEAICCPYPPLILASTAMKVVSKLVARVLTTIICLGYGIARPHLTVPETGLVVGLALCYIVSTGVLEILHLSNQAQGNMEPPVVWEALAIATDGCFAGWIFASLVLTRKTLRRTGQTAKYQMYDILFKVLVVFIVLAFAFTLFENAVYAKRIASFPWEYLWMLWAGSRLLNFAVIVVVSIIWRPTETSFLYANSMQLPSSEDDCAKQDVVSQDSPGIQEIVVEEEKKSEDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XTU4</accession>
    <name>A0A6G0XTU4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb/SANT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_001667</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0744034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XTU4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017685"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024752">
        <property type="entry name" value="Myb/SANT-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12776">
        <property type="entry name" value="Myb_DNA-bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like" evidence="2">
        <location>
            <begin position="16"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0744034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="189" mass="21303" checksum="8727B56B62D3A0CA" modified="2020-08-12" version="1">MTQKTARTQQLDKPARWTQELDDEFVAYYVEIAGRAHDVASGGKCLKNAGWQAILAKLDGRGNIVDINQLKNRWKRLKEDYVDYAWLVKKFSGDGLQGIDDAKWAELDEGRKHKYSRFRFTPFRHYSVLDGIVGDSMANCEYMRSAAGMRLCNEYANSSVLQSNVSASDESLDHNQEGTVPETMTAAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XUX1</accession>
    <name>A0A6G0XUX1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_000824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XUX1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018847"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0744336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="225" mass="25440" checksum="A1C85B4082278EB9" modified="2020-08-12" version="1">MQAWTSTSPKNEEILAAHSYHDETQDEQVSCKGCRALLTENQLLRELLLRTSTDAQQIIHSFEKQMEFQRQRMEVASGLKNKGPVMAAAVVKPKPTGVLSQQITPDIFRKLSQSAAQELVKVHPEYKELYDIAANSKGSLFERLLSSDVFTEEQKRKQLQLLQLRQKELNDMDVQPKIVAKSPKAGHISTAKTPVSPRNVPRTPEAAGENYFKLHNSFSLSLRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XVA9</accession>
    <name>A0A6G0XVA9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Guanylate cyclase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_000898</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XVA9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021038"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008074">
        <property type="term" value="C:guanylate cyclase complex, soluble"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070026">
        <property type="term" value="F:nitric oxide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019826">
        <property type="term" value="F:oxygen sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038060">
        <property type="term" value="P:nitric oxide-cGMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070482">
        <property type="term" value="P:response to oxygen levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655">
        <property type="entry name" value="GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655:SF8">
        <property type="entry name" value="SOLUBLE GUANYLATE CYCLASE GCY-33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="159"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="289"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="626"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="650"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="681"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="730"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="753"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="5">
        <location>
            <begin position="359"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="5">
        <location>
            <begin position="826"/>
            <end position="955"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0744417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1063" mass="119373" checksum="4AD0F3066858CAA4" modified="2020-08-12" version="1">MQTAPRLSLLPVERPRVHAKRRLSSAVVPSQHAANSSVLRVDARLMVAPAPNDVIENRRRSFISSKEKNSERHVVGSSKNVPYYLGGATLQNRAYDSAMRPYTLRFTNVQLEDVFRKHYRHYVRGKVQMGCFVSVLLHVIMGLLEFVFEYGHPNEETLVIARCCIVAVILIFYRITKRIDFHLHFEAWMVSFYLLHGALVVGTSVLFESVCSSPSDHIDTNDGRHEDIYLFYAGRWSQAISLIFLSILFNASGMMFIFATFCAWVHVFLMIVVPFALYPGKSELVDPQIAYGPILTCFCMLSAYNSEKHIRREFVLRCNVADDRKRRDDLLETMLPVHIKESLKANRTNALADQFDEVSILFCYVSDFGRLSKSTSAIELVQLMNRIVFCFDKATDSRGVYKVEAIAETYMCAAGVPIRDPFHHEKIADMALTMMCIQEQEQWTCNNERIRLQIGIHSGPVVGGVIGSKTYSYHLFGDTVNTSSRVCSSSMPGRIQISERTSQLLARSGCYNVTPRGKVALKGKGELMLYWLEKKIGQPQRNILRLSTRFDLAEEVAIATQPSIGDGRAKVDDDKVALVMNKRTLQFEPSQGSVMLEQVSYRMQQRMETAFVVDYNMANLAQWRTAVKAAIAVLVVATIGTSQSPSSEKWITVALASVCVVLLGLLYMYSFRKKFRSHMQPIAGVVVGAVIVTLNFNLVLSPGSNILNLNIVYVVLVSLLLRFRFVTSVAINTAILTTYFVFLLASYHALSNIVGYLCITLFCAAIGEYSCYRREAGLRADFLLKHALNVEKKKCEELLANMLPSAQYAEAILLHGTIVDELNDVTLLYSDMVGFTALSATLKPVESCLLLNKLYSAFDRHLDSLGVYKMDTVGDAFIVIGGLPNYTSEKNHAIAITAFAVEMLREMESFRRREHVQLQLRIGIHTGKVIGGVVGIKKPRYLIWGSHTVIANSMEAKSIPGHIQISDSTYRILRASGQYVCEHAGNSALGDTYFIQTDTAPAKAEIVTQYFPKPMRKQTRTEPELEQFFQAARKDNPFFQNVQLISDASRILHKISTKPPPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XVK8</accession>
    <name>A0A6G0XVK8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GOST seven transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_001030</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XVK8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004399"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053937">
        <property type="entry name" value="GOST_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009637">
        <property type="entry name" value="GPR107/GPR108-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229">
        <property type="entry name" value="LUNG SEVEN TRANSMEMBRANE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06814">
        <property type="entry name" value="GOST_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026311176" description="GOST seven transmembrane domain-containing protein" evidence="7">
        <location>
            <begin position="22"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="GOST seven transmembrane" evidence="8">
        <location>
            <begin position="182"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0744556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="443" mass="50564" checksum="BAEE46EC1334419B" modified="2020-08-12" version="1">MSVPTTLVVVVMALLAHMSVSVRTKFNHRFVYKDFLDSVLNSEGMANRWNTRSPIEEFGMEVGSEVILTVDHADAPVTFSLYNYRQWELYRSLVFDVTSLEGYKESLALTCFHPSTARIVFNPAKDAPNTTYKLQIGLASQYTLQVQSCTSENNQVNASISMVNMGWDNTLSEHMGVEELGLIPIYSVLVVTYALGAISWIYDCLKKRHYSSGINLVFAASLVAETVHCLSKLAYYRAFSVDGNEHSVYAKFRDISESVSNVIFLAFLMLCSLGWSWTRRYLNSQERRFFSVLFAMYLTVALIKASCDPKLQMCQAYMLTEYALKSLMLLGIIIALNYSISRLHVKLDGTRWQGDKIPKLYARLELLRQFRWSFLVYLLLPSFVLIFNIGVINPPGTWKFFWVSCLVEELIMFGIYCHMAYALRPISPELYQMICKSEPSTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XVS9</accession>
    <name>A0A6G0XVS9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_001064</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XVS9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009474"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005629">
        <property type="entry name" value="Skn1/Kre6/Sbg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361:SF1">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03935">
        <property type="entry name" value="SKN1_KRE6_Sbg1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026149731" description="EGF-like domain-containing protein" evidence="7">
        <location>
            <begin position="18"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="652"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="633"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS01186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0744597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="724" mass="81284" checksum="A38A846E13F7B67F" modified="2020-08-12" version="1">MRRSFVMLLWLWSINDALDLDDTTVSPKSGIGVWIDIDTPLKAHSKISSRGDKWNLVMSDEFEQPGRLFKAGHDHLWTALDLPDGVNAALGWYNSSNVYTTEGKLVIRVDEGPRNATYFNQWLDSPQYETRVLHYTAAMIQSWNKFCIQGGLIEVSVKLPGAVDSKSWNPHVQHKLNPKTVISNIRFYPTWPGIWLMGNLGRALFLGSTSRMWPWSFDECDPELAMHQRINACNSTPGYGLNPRQGRGAPEIDVLEGGGTAISSSIHVSPGMPDEFRRIPPNSKAPYWDSSFCFYNNNCRTPGANIADAPTDTFAHRGHPSWYQNLRYGSNDHCPSNADKIQSYDDVVAAKGKITANTYDKTQMSAAQDVHADLNWIDGKSSRKKRWGINVNGTCFAISNGYVGTFLCDPDSRNPKCAKPRLPTTPLTKQMAPFEYQMDAISANWDITFDAYTSFYRYSLEWVMGRQGYLRWMLEDAPVFEIPAESLENVPKSNTTRNPAKLMIEEPMYLIVNVAVARAWGATPPNANVGPCRGDGINPPRYSREWNFSNNICNSFPMFFQVDYIRIYQATTGMSVGCDPASHPTKAWIDGHIDLYTDFHNRDVTVAGGATCRIHNDCTTPMAPSGRCVSQRCVCAFGYTGPRCTKLSAVKLASPSPTLCAILTCACIILVMTTDLMRKRKMALARVETELYRGIQLNAIAMYDDFDDDDDVYTVDWEQMPQEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XX27</accession>
    <name>A0A6G0XX27_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_000323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XX27"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018143"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="266"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0745293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="326" mass="35306" checksum="5FB1DCE8B8B8CC5B" modified="2020-08-12" version="1">MNLGKLMRTARPPPPVEPPPANAERADGRNASAVSTPTGQAVVKPVDLSGYLSKDHGISTLGETDGGASSPASQSSPPRASRRKSITIPDPSSPKRPSAQVSFETVTAASKEAARRVTENPPKLLNDLEAKLNHSNSQKSSPRKQTTDSDADVSSMPICMFLIHVQRSTTKRILRPVRYLEEKVRHLEADNARLKQMTTLSSSDADKKRIQQLEAAVADAVRAERRALHLVVSAIGKDRMKTLLEDPKFADMSIEDRIVAAAAAVSRTNAKPSSSTSSATKPKPPATSPDKDAIMARSHELDLLWQQHCSNLNASTAFDRTLRRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XXU1</accession>
    <name>A0A6G0XXU1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Anoctamin transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_000356</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XXU1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006856"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF73">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="448"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="510"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="559"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="768"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="821"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="877"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="7">
        <location>
            <begin position="327"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="223"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="238"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0745329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="942" mass="106923" checksum="7D99484068ED3787" modified="2020-08-12" version="1">MADTQDAIHTAIKEDSEQDDSSGDTTSNYIPRRTKSFESHDQTTTSLQLPRVRTYTKSLGSLVKHLASDPSNPHLTASNAPATPSPAQVERTPVQSQSVFSFPWSNQSKQTFEAAVQDHIKPLPYEFALVLHNKPARARDLELRGLDDAGCQQRDVIRRCIEAGLDVTVMASTLHSRKYMCLLLKPTPQRMKIEKNRLVVERWLQIGAVGEVPSEIEQLIYKSSLGSTPPSGNHGDEGNENEEEEEEEEDSKFTPAERIQTIGRIISSTADKAQLNPPGAGISIEAPTARDPIIAACFPLHNRKVNKMLLGKKHKWWTNANDITSTIRYHYGEHVAFHFAFLFLYTQWLVLPALVGTILYLSFRWYTAIYYMTGLAIFGFVVVTIWGTAFLKAWERMNEYLNDAWNVRLFKEADYPNSRFRPHGYVDIVDSKGVLLYREPYYNPLYRIPAYILTFVVFLFFTLIYVVGISFFVQWYTAAMCAPVCSECPDCSGFLTCFDTQSATVGTWRWLYIFVQGIFLGVTLDVFVYLLSVKLIRVFVNRENHETEAQVDRTMINRLFIINWISFFLWFMLIAFVIVPFGKDVEGWMNAHFDWASIYTVRWQNGRIDMSTALVTPLLITQALNLLIDTALPHALRRHRLLGFRTVRRLRANPAETMLALSEIQSQFQRRQSLPPAPAGSTATASLKFNEKIELQMITPIRIPYIEADLGVNIPTTEGFENEGVLATIELDALTLVVEFMTADSIVEESQLDLYETFPDYLKMVIQFGYVVMFSVVWPFCGLAALANNVVHIQNCFHKLCLTRRRPVPRKANSIGQWEKTLYTTLFLAIFAVVGLICLSSGEVEYFVKDCLALDRFNGTDYSMTPELSCFGLPSRFLVALVLEHIGLLVMYLIMDNIEGTPASLRSSFQLKKELIRRAIYNQNGPAIPTPAIGRTPARDMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W2G6</accession>
    <name>A0A6G0W2G6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Reverse transcriptase RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_019239</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000543">
        <property type="protein sequence ID" value="KAF0721041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W2G6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019640"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase RNase H-like" evidence="8">
        <location>
            <begin position="105"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase zinc-binding" evidence="9">
        <location>
            <begin position="374"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="249"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="269"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0721041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="474" mass="53591" checksum="4C0E1F671ECF3EE8" modified="2020-08-12" version="1">MSKCKWGRSSVLFLGHIVTPAGILPNPEKIKSVLRIKTLKDASEVRAFLGLAGYFRRFVRDFSKIAAPLTLLLTEEKFTWTPACNESLEKLKRSLVSPPILAHPDFDLPFAIWVDASHIAVGAVLMQKQNGKNRVIAYASQSLSKAQQKWISKEMGISEIECWGVVWATRKFRPYIDRRHFDIYTDHEALTWLFNTGSRSGNHMLARWAMEIQGLDYTVIHKPGELNGAADGLSRLAVCPIQPHSMRRLNSTTTGLTTPPTMNVRNDDESPGLDQDNENDNQLTRKPPVQGTPIELFDRRGRPTPRLYNEQANDPWIVALRAFLEEGAIPLDPHLQNLVVRNSHQYVMQRGIVCRYVTIKTPLRNPELVVVPVIPHTLVEEVLYASHASSLAGHLGLMKTRERIRRTAYWLNWQSDCKGYVSKCPDCNRAKGGRPWKQGPMQRMPIYSLRGPFGLVVVDALGRCPQQTVAINTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W440</accession>
    <name>A0A6G0W440_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_018881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000363">
        <property type="protein sequence ID" value="KAF0721815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W440"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004186"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="203"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0721815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="244" mass="27628" checksum="797D0B74F00992F4" modified="2020-08-12" version="1">MQERVDDSEAVVKELRAKARETRLLAEAAEALSAERSNTFQLLLSEMKRTQDKIRRRDEEERVRYAQLREELKVERAETLRVLHEQIDRSYEQLNRRMKLKTSLMQLQRRSSDETNQLYDQVMALLLNRVSPVDGFNQNGTERLNKDLREEPRSRYPRFEQAAGGASAGTAGMSMVVASRGFSLSGSSTKPPGNSGSFIPSFVQTQSTSTKRSRSSVQCLPPSVNVSPMTTETLNLTKRSKKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W4W0</accession>
    <name>A0A6G0W4W0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_018715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000349">
        <property type="protein sequence ID" value="KAF0722078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W4W0"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0722078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="136" mass="14207" checksum="B76776EC7CC7D7B0" modified="2020-08-12" version="1">MLATCGVERRLEPSPRSCSVRCCCHQEDPTQQRRHGNVTVLKLLEPLQESLKRPKNVAKCFDFIGIGSALVAELVGSLDVALVLKHAHTTDTAAASAIGSSVPGAAGGYLWSAICGIVGGKVDFCGGGKSTDRAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W4W7</accession>
    <name>A0A6G0W4W7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">Ae201684_018667</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acetyltransferase enzyme. Acetylates histones, giving a specific tag for transcriptional activation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000346">
        <property type="protein sequence ID" value="KAF0722128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005712"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02249">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.20">
        <property type="entry name" value="Coactivator CBP, KIX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1020.10">
        <property type="entry name" value="TAZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031162">
        <property type="entry name" value="CBP_P300_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013178">
        <property type="entry name" value="Histone_AcTrfase_Rtt109/CBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036529">
        <property type="entry name" value="KIX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036546">
        <property type="entry name" value="MED15_KIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038547">
        <property type="entry name" value="RING_CBP-p300_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035898">
        <property type="entry name" value="TAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000197">
        <property type="entry name" value="Znf_TAZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13808">
        <property type="entry name" value="CBP/P300-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13808:SF1">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08214">
        <property type="entry name" value="HAT_KAT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16987">
        <property type="entry name" value="KIX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02135">
        <property type="entry name" value="zf-TAZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01250">
        <property type="entry name" value="KAT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00551">
        <property type="entry name" value="ZnF_TAZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57933">
        <property type="entry name" value="TAZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51727">
        <property type="entry name" value="CBP_P300_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50134">
        <property type="entry name" value="ZF_TAZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0010">Activator</keyword>
    <keyword evidence="15" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11 17" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 18" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TAZ-type" evidence="22">
        <location>
            <begin position="541"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="21">
        <location>
            <begin position="988"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="domain" description="CBP/p300-type HAT" evidence="24">
        <location>
            <begin position="1218"/>
            <end position="1620"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="23">
        <location>
            <begin position="1621"/>
            <end position="1673"/>
        </location>
    </feature>
    <feature type="domain" description="TAZ-type" evidence="22">
        <location>
            <begin position="1679"/>
            <end position="1760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="172"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="656"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="882"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1467"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1771"/>
            <end position="1801"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="765"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="1067"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="656"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="667"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="20">
        <location>
            <begin position="890"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="1467"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="1791"/>
            <end position="1801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KAF0722128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1801" mass="203466" checksum="B8077CE5A37C4E0D" modified="2020-08-12" version="1">MVALCRWIKCTQRCVSHIADNFQDDNFWVSISFDFNDQPPSLSCTFVKAAAATPVTASPFYPSFVRAHSAEGFHRQCRGCHLYSSIPPLEFARSRSRLSSFHVTTILTHLDILGSFRLFSKAEWLSAPLHSCVMVVKLEQPEASLHSSRLAVKQSHGRASSKGKATLPCAQIDTQRPPRNGRAYRGAQRPYPGIRLSRYHPTRSANPPMDKTFVGDFGLGMGDATNMNMFPFNPAAGNANMNQMNNPMANQMNSAMQNPAAMNMGQYNAFQMGNMGNMFMPNGTMPMSTNFTGLPDDMSGGTTGQTPGAIDFPDEFNSQATSMAPNMMPMNANMQMNAMMMNNMMMNPNQFNGLGFQQMMSNPMFGMNGMNGMTPQQQQYLRQQQFAQQQMMQARAQAMMAAQAANPQPQMGVPNTTGGPTWQVEKADAHIRHEVINKIVAFLRNQKPNAPADWIRRLPQMAKKLEEKLYRSAKSKEEYMNDSTLKARLQVVARSFHAARAQNPPELVGFCQKVAQITSTLPVQAAMDYHQKVQVMMTEQEKNRPVLLKQQQRLLLLRHAMWCQEQPGTCKATPQCTEMKALWAHVGVCANVSSCPFEHCTSSKFVLSHFQQCTNSQCIVCSVVRQPIEAKDVNGGLIMDPQLAIQKINSLKRSASEMSIPAQSPTAASSNPVTPVPVSTAATPVPSPSPVPSTPTASMPQQQQFANQLAMIQQKFKDWSLEQLQNHSKKLESWAEQLKSQMQIISSECTKQIDMFKMALDPAAKVQYQSQVEEGQKQLKELKAKFARCVNQHKIMTLTINGRLNGGTVTPSPMHAPAMNHQVAMNHPMGMNTFNMNPAAMHQVPMNQMNPMAVNPAMNISVVPTMPTQMLQTPVANQSMQSLMQSTMQPTPPPQPKAEPAPPPQPAPVPVPAVEVKVEEAPPEKKIKKEPALETESSISNVGSTCMLPQMSDEEIQTHIDSLRQQHCASMTVAQLKKRLDPILKSMMDHKYGWIFSSPVDPVALGIPTYLEVIKRPMDLGTIKKKLEGNFYKHIYPFAADVRLTFRNALTFNSEGEDVYLLASDMLKDFDCEMAKLEAEVLAEEEKARSKEGACKLCGAESLVFEPAVLYCNGECNAKIRRNNYFYCSSDNKYHCCTNCYPNLPESIANADGGAPYVKSDLLRKKNDEIHEEPWVQCDTCNQWVHQICGLFSDKEKSQEFQCPLCMLKGRKPVEKKVWTAKSLPRSKLSDFLEKRVSKLLEVEMKDEIKDSKEPSSLPDKLIIRQVSNIEKTLMVRDKMFQRYKEAKYPSEHRFKSKCICMFQEIHGVSVLLFGMYVHEFDQQEAKCNSRRVYVSYLDSVNYLEPAYMRTKLYHEILIGYLEFVKQRGFHTAHIWACPPLKGDDYILYCHPETQKTPKSDRLRQWYIQMLMKAKEEGIVVDICNMYDEYWTTPQSSPADLPYFEGDYWVGLAEELIEKLDEDVKAKKKKDQKSKKPNKQGKDGSAEVEFQDMLMKKLGEVIQPMKDDFLVVKFFPSCSQCKVMICQGTIWKESKTCLCDTCYQSQILNQAKKETPPYIPIVLTLKEKCTDPDDIVESEVFDTRQAFLSLCQTNHYQFDELRRAKHTSMMTLYHIGHPPNGYIYSCNVCKADITSGTRWHCNTCVDYDVCATCYEKKTSIHVHILEPVGTVTDVMRKAREERKKSIALHMQLLVHASSCEEGACTSLNCEKMKELLRHGAQCKQRATGGCTICRRVWALLQIHARQCRQTECRVPRCKDLREHLRKLALQQQHMDDRRRAAVTEQYSRQGTTEEKAEAGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W5I9</accession>
    <name>A0A6G0W5I9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_018963</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000369">
        <property type="protein sequence ID" value="KAF0721723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W5I9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020977"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0721723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="154" mass="17896" checksum="C64E0EC435B14305" modified="2020-08-12" version="1">MSGTQAFETIFKDKPTTRDGIMTAFNSLLQEIQPTELQVELMWAQWDLILQCLVPQIYNCDAWVPYYTKHTVNWLPTQLMRLLSNDSLHRLLLSPLEDKLLGWLQSQKWENDSVETLVNLKSQSPGTFAMALQIISEADKLLLRYQHLQYPLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W5U5</accession>
    <name>A0A6G0W5U5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_018395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000332">
        <property type="protein sequence ID" value="KAF0722486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W5U5"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0722486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="106" mass="11731" checksum="298C28F851F6777B" modified="2020-08-12" version="1">MHGGRTQYSVCGEDCCSTELVPTRCSSPKGSRVEQSFSWLLTRERLDDKRLFGMIADRVVGGTFSLFIYSTPIHPSSGSSTRSLTLTCIFAHMASLSLYALLRSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W8D3</accession>
    <name>A0A6G0W8D3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_017585</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000303">
        <property type="protein sequence ID" value="KAF0723552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W8D3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006640"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13999">
        <property type="entry name" value="STKc_MAP3K-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF214">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="426"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="365"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0723552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="691" mass="75035" checksum="3A5FC2E4B08EE1C3" modified="2020-08-12" version="1">MTLLACSDVDKLQATCAAFAVQEADYCSVAACVELESLRERCEHGATRPRCSTAVARRALLQSASSDLCTQSVIDATHQQWSSKPATAQCYFASITTTNVNSTLIATKDCKDPNCLAILVENQQLAAAYPSLDCKIYDVVTKQTFTTGDMANFCNATTTAATTTTAAPTKATGPNALCSQEVMDLNYRVWSNITAAKSCYFASIADPNFDSTRLLATDCKDATCYYYLVQNEAAAKKSPNTDCRIYDTATQQTYLTGQLASLCTAATTTSTTTATPSKSQTSKTPTTTTTAQFLTEFTPSPAPTTGSSNTGMITGIVAGVVAVVLLAGLFICMKKRKQHKPEAIHEAAPYRSVQDESNYARPRATTAGTATATNASKIPSSNGASTVASSQASSGPQPTAAAVVTMRDLEKDMIELSLHRIDITKVHLVQRIAEGAYGQVWLGEYLGDRVAVKKLLANKASHDDIRAFAGEINLLSKIECPFIVHFVGVAWTKPVDMMLVTEYMDRGDLRHVLQSKQEFPWHAKLQCALDIAEGLVYLHTMDAKIIHRDLKSRNILLDSKKGAKITDFGIAREADDFATLTLNLGTYRWMAPEVLKDGHYSESADLFSFGVILSELDTGILPYSDLTAPNGRPYTDLNLMQEVTAGRLLPTFSQECPTWFYNLGRQCLSIDPTKRPTALQVAFIIRNKMTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W9I6</accession>
    <name>A0A6G0W9I6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_018077</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000320">
        <property type="protein sequence ID" value="KAF0722845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003580"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000289">
        <property type="entry name" value="ABC transporter G family member 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="551"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="583"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="612"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="640"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="688"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1099"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1140"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1182"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1207"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1238"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1330"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="114"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="767"/>
            <end position="1005"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0722845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1359" mass="153009" checksum="8AFEAA49A8C2A188" modified="2020-08-12" version="1">MTSPTSSAARKPLLEDEEKLPEVYNSLHFKSVQDPYRSVISDRLSNYSTIHANDVASMLSGGLERFYEKYRLLSKKANLQLATPEVRFEKLSYTVQARELTIAEKQGTVGSYITRLFFPFKKAVYKEQKVLQSMDGIIKPGSMTLILANPGSGKSTFLKALAGKLEQNNKCVQGGEITFSGLKSTDVDPLKIVGLVDQRDNHAATLTVRETFKFADMCLNGDPDSVPEELRDVAKLRTEMILQLLGLTNCAETVVGDALLRGCSGGERKRVTVGEILVGGQSVFLCDEISTGLDSAATFDIVSSLRTWCKTLGGSVVIALLQPTPEVVEQFDDILMLNEGYMVYHGPRTSILPYFENLGFYCPMRVDPADFLIEVTSGRGKKYLAADDKQRKIPIFPQEFNQVFVESELHRATRAELDAGFHVPAHLQSKEDFAKMKSVTAIARTKETSPFAMEFLESTWLLLGRQKTLWLRDRPLLWGKFAEAAIVGACMGAIYYSAPSSIYLRMLFFSCSVFQRQAWQQIVIAYTLRSVFYKQRSRNFFRTFSYTIAESIVQVPVNLCVSLLMCTFFYFMSGLTRDAGRFVVFLIICVCFQHAIGAYMTFLSSVSPSITIGQTLAAFSVCFFLLFSGNIILHDLIPNYWIWMYWFNPLAWALRSVVLNEFTSDKYTPAEQLANLKNVQMTSFETSYIVYGIVVLLCYYVLFTVLNTAALHFIRYEKRYGVSGGSKVGEDDEASTYVEIATPGGTMVKQERKKNQGLAFIPANLVIKNLDYYVTLPTKVERQLLNNITASFTPGRMCALMGATGAGKTTLMDVIAGRKTGGRIVGEIIINGEPKNPVNFSRITAYCEQMDIHSEMSTIGEALWFSANLRLPESISAEEKRNLVEETLDLLELNGIINEQVGDLSVEQKKRVTIGVEVVANPSILFLDEPTSGLDARSAITVMKGVQSIARTGRTVLCTIHQPSISIFELFDDLLLLQRGGFIAYFGELGKDSCKMLEYFASIPGTEEIRPQYNPATYMLEVIGAGIGRDTKDYSVEYTNSELCKYNVEKAHRLALPSPEFVAFSTLKYTPMATSFGNQLKECVVKCAQTYWRSPQYNFVRLASFPWFAIVFGTTFWQLPRTTSAQIKSHVGLIYNSMDFIGIIHLMTVLDITCLERAVFYRERMSNYYGPLPYSLSLFTSEVPYLVVAVTIFVVVEYFLVGWVNSYFFFFWITFLLYTSLCTFFGQWMCALCPNTKVANVAVGALSCIFNLFSGFLLPYPFMKGWWYKWLVYVVPSSYSLRSLAASQIGLCENGEGNACQLIQGDPKFPNTTVADWVQIQFDFQSENRYYYLLVLACMWVILQICIYLTLKYVSHLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WAF1</accession>
    <name>A0A6G0WAF1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_017348</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000294">
        <property type="protein sequence ID" value="KAF0723854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WAF1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006683"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0723854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="266" mass="30806" checksum="CB84B24C9D9853D1" modified="2020-08-12" version="1">MLDAQLKTARALERLLKRKPYLELSSDISAQEWCMLRLGTDPEQRLRSMRAITDQVYDKLESDFIKSRVYDLKDGQCGMSVRAVGSALSFDFIQSMVTDTIDYDTMQTWMWSLMCHQVYTQNVPKFTSTSETLESPEDNIAYIRADTTIVVKGAKTHFEGRWVVRMYVEANRTVFITQSIMDDALYPHAPDRKRDRSTCWAVLERHPTDPTKTRQYYLLQCVPGLHIESPDKGNTELMLYQGEMTEILLNVMRNCMESLKVASLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WAH5</accession>
    <name>A0A6G0WAH5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_017035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000276">
        <property type="protein sequence ID" value="KAF0724222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WAH5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018681"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37558">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37558:SF1">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0724222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="229" mass="26150" checksum="59B88CE3697911B5" modified="2020-08-12" version="1">MGYPTPTECRKFTDDEDIMLLRQVNAERPFEARQGEITKAGTSVARALNEHADFRRPGFDYKKAQHRFGILIESHRSFNRDSSKASDINEGYGGKLQLLDELLSAVDDTNSDERDRLVQTVVVSQRSELEGSIIREEALSTLGKRKSSENDKDGGSTNTSRFAKLAAAIQEDTKADLEFREAELEFRKYQYERDIEEREKDSEAARGQAHLQHEDLTAMLNILQKKYDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WAQ8</accession>
    <name>A0A6G0WAQ8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Structure-specific endonuclease subunit SLX1 homolog</fullName>
            <ecNumber evidence="8">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_016989</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Forms a heterodimer with a member of the SLX4 family.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the SLX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="8"/>
    <dbReference type="EMBL" id="VJMJ01000273">
        <property type="protein sequence ID" value="KAF0724327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WAQ8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021476"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033557">
        <property type="term" value="C:Slx1-Slx4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10455">
        <property type="entry name" value="GIY-YIG_SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="entry name" value="GIY-YIG endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03100">
        <property type="entry name" value="Endonuc_su_Slx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027520">
        <property type="entry name" value="Slx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048749">
        <property type="entry name" value="SLX1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050381">
        <property type="entry name" value="SLX1_endonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20208">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21202">
        <property type="entry name" value="SLX1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="10">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="226"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="229"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="277"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0724327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="328" mass="37625" checksum="DAD98769B1B4FB53" modified="2020-08-12" version="1">MKRSYIGFTVTPQRRIRQHNGEIVNGAKKTLPHRPWEMVLVVYGFPTKELALQFEWVWQHPYSSRFTKPTMGHLKTDKSLGNMRCIQRKIRELHLILNLPPWSQLELILSYTSQEMFDLGQSLDAFQLPSQMRIVMVSLDELPASHDTLEEDQQTTHDCTECSEPIAPDQPMLQCYHLACPMKAHVPCLSSKFTLLESSVPHLGTCSICNDELVWSRLLELAVNPTESKKRKPSWRERTRRKKARATSKQAKRQTRTKNGSEEESTDEVASASPRSSVDHPNSDHYGWENHEVVEILSSTEEETLIPSENGMDEADLTPCEIDLTQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WB98</accession>
    <name>A0A6G0WB98_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_016812</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000269">
        <property type="protein sequence ID" value="KAF0724518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WB98"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006887"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000003">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0724518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="424" mass="45788" checksum="92F4B7D5B77764CD" modified="2020-08-12" version="1">MTLVRRFLRKPTLLRTRGLHASAPRERLPLVIATVGIGLAITTRYVIRAQERVRMQREAEENGTSTTGQRARLVLGLDLGSVHARACGLDVDRPNHYSFAVERMAVQIRHGQLVVGDLATKNAVQNLRDALLKPRGESILQEDDVSVDSVLEILTETLHGSVRSSLEMPEAFDERTACVLALPSAFNSEPSHARLRELLGHAGLDVLDFVPEPVAAVLAVDEPLEDQTVAVFDMGGTVSTCSILDLSSPSPTVLSSISSTTLSGDGVTAQIVDYLAQTFEDKHGIDLRQDSLAVERLFQAAEAAKHELSTGRRVTQVHLPFITADQRGAKHLEQSINAATMQRLMDPSLTQSAELCHQAMRAANVSSVDAVVMAGGGLKSPILQTHILHAGFPSATLVHLATQVDQAVALGATKRAQQLLDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WBI7</accession>
    <name>A0A6G0WBI7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP synthase subunit beta</fullName>
            <ecNumber evidence="13">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ae201684_016694</name>
        <name evidence="16" type="ORF">Ae201684_016695</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 13">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="13"/>
    <dbReference type="EMBL" id="VJMJ01000266">
        <property type="protein sequence ID" value="KAF0724628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VJMJ01000266">
        <property type="protein sequence ID" value="KAF0724629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WBI7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010523"/>
    <dbReference type="OrthoDB" id="61577at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042776">
        <property type="term" value="P:proton motive force-driven mitochondrial ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18110">
        <property type="entry name" value="ATP-synt_F1_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18115">
        <property type="entry name" value="ATP-synt_F1_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01133">
        <property type="entry name" value="F1-ATPase_beta_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1140.10:FF:000001">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.170:FF:000004">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000026">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050053">
        <property type="entry name" value="ATPase_alpha/beta_chains"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184">
        <property type="entry name" value="ATP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184:SF82">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039072">
        <property type="entry name" value="ATPase_subunit_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 13" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 13" id="KW-0139">CF(1)</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="157"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF0724628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF0724629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="492" mass="52517" checksum="AC54F01497CEC301" modified="2020-08-12" version="1">MLSSVLKRGLSTSAPSVGRITQIIGAVVDVQFTNNLPPILNALEVQNTNDNVRIVLEVAQHLGENTVRTIAMEGTDGLVRGQECVDTGNPIMVPVGPETLGRIMNVIGEPVDERGPINSVHKAPIHCAAPLYTEQGSGAEVLVTGLKVVDLLAPYAKGGKIGLFGGAGVGKTVVIMELINNVANNHGGVSVFAGVGERTREGNDLYHEMIESGVIKLNADGTTTGSKAALVYGQMNEPPGARARVGLTGLTVAEYFRDVEGQDVLLFVDNIFRFTQACSEVSALLGRIPSAVGYQPTLATDLGALQERITSTLKGSITSVQAIYVPADDLTDPAPATTFSHLDATTVLSRQISELGIYPAVDPLDSKSRMLDPRVIGEEHYEVARATQKLLQDYKGLQDIIAILGMDELSEDDKLTVARARKVQKFMSQPLHVAEVFTGKPGKFVRLEETVASFKAILAGEYDDLPEAAFFMVGGIEEVKEKAKALASELDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WC24</accession>
    <name>A0A6G0WC24_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_016588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000261">
        <property type="protein sequence ID" value="KAF0724839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WC24"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005073"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0724839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="317" mass="36365" checksum="437FA70B701309BD" modified="2020-08-12" version="1">MTEPWPWHVLNSADVPLFDSFDAFRNASFAYFYSVFNNQTLEPSTVLCRESATNSNLVRKNVALPEHVRPDNCMDFVCRWPGAVFYSSGFRRFSCDFLAQSNANRTSKLWFDCEHAQFFGTPMSEVCIWIEPTRENDQGNRLFTVYHVSLIWEKAAWSWAKLALRGVLSSYIIRVLWRRYYRHYPPLLVNLEQIGLGAQFTKYIVLIGDPSFLILSDAFVPVAMVVDILFGVAYMTDAILRVSQFSDFFAFVLGCIYISRYVWTGYLVMRFLSWVVKRRGDVAKFAPVDPAILALAAYFYGGPVLSLIANTPLMQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WC97</accession>
    <name>A0A6G0WC97_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mediator of RNA polymerase II transcription subunit 14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mediator complex subunit 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_017278</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the Mediator complex subunit 14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000292">
        <property type="protein sequence ID" value="KAF0723897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WC97"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020773"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055122">
        <property type="entry name" value="Med14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013947">
        <property type="entry name" value="Mediator_Med14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809">
        <property type="entry name" value="MEDIATOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08638">
        <property type="entry name" value="Med14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0010">Activator</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit MED14 N-terminal" evidence="8">
        <location>
            <begin position="12"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0723897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1055" mass="118264" checksum="32E03DD3E8855145" modified="2020-08-12" version="1">MDLSAQVQTEPVELRDLVSRCVNRSYDSIRTLTMTLPNAPKTEERRAQTLEKLVDARNVFEKLLAVTRWSVQSPIAEQCTELLKHATVYQDQLDETSDRLSYLQADLNRAKERQYDLQTAIDVLFRGSYSKLPRVIHHALHPRELPPVDPDKSSQDLDDMIRFRLIEQDIPEPFGDIDIQGGFASTHVDGQFNVVFTVNGNEPDSLWRIIDVSTVLSDPVARKTTHTNTCVTNLRIISANTPTSEHYRHLKNLVQKRCNETQRPLQSALDIMSDFCRKLALHILLAQGHVLATRRWPHTNFEPSENALTIMYWDDLSKITKEEAPPSRRGLCIQLRAESSSSDLFSVHLDPLPPRELYNLYPELLRALKTPSNLYDLNVEQFLLGGMHVHAASALFCLERKLVLGASTPLHLMTGEAVSLVRSTRSFRIARLDSTGQSPLEISFEMRTGRFAVFCLAVAKSPLVARAVSSMESTLLSQVKVVASSGLFALSFEDENVVHTALAFVLREIVAFELSCFAASCANVEVQRNVQINWDRYINFRQQTGNSIESLSLSPHALFFQIVRNKESSGYLVVEFDRLADMESDVQNEEEWVRSPAFSLLQLQTSSIPCAVQFFQRFPAFRKDSLPFEPPPSSKKRRLDGTLPMIASLFLHVISLCHERIQLQHYVNFARRRVVKIKYAGQGGTSTNGVTTGEQIVSFPFPNRVSVAPLVIRAVHGHLRKRGGFEMCVQLSTLPFDFILPKKQSNYNITHHSATAQGNLIFRYPPIQKFQPDNPLETFMADLIMHVKPMAEFGVKLQRTLSAVGRYTSSDDIRDHFFVERADPFGFVLACRTANPKRCVAAGSTVDNLVTYRITIEYNPKSKFVLSSSHKAEHPLLHFIEAAFNIHTDSAQLLEALERTTIPLGILSSTVCSQLISAKCYRQDQAPEKPNGVMGGGGIGKKGGKGSKGIRIAYKAKLPGEEKGYYAEKSYGGDDKSFVPAELLLIPRSQNHIRLTYADRCGIDIFFLENEMVNIRSAPSGVRVPSCSGDGGITVSHEAFGERLKGVIFPEMASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WDF7</accession>
    <name>A0A6G0WDF7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_016264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000247">
        <property type="protein sequence ID" value="KAF0725247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WDF7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001640"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="115"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="196"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0725247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="343" mass="38792" checksum="610F28598037045A" modified="2020-08-12" version="1">MTDDGSRHPTSIQSRLQAIRTLEAMHALEDQVANLQAKLREMEAQSHHAAHISFMMQRNQELERLVVSSFKETEAIRHEVVRLEKLRADHANALVVKSHENFALSQENSAQQQKIAAIQSQLSDVQQLNQNLMAKLSEAEAKWRQLEQEKLQQVNAPALLSQLESQQQRLLAVEEPPPPDPPVVCSICSGANKVANDKLKRQLDAVVRQRDKLSKALSDERGTIQSLQDDIAAKSNDVALLRAQIHLTNQELDKCRRYIQEAELSPSFERYMSLKAKNLMLVQQLEAVKSPASPTNPPFEPRPPVELKKKKPKNVIMPLVRTNSVTSNNNHGDRPSSWFRLNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WET0</accession>
    <name>A0A6G0WET0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_016484</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000254">
        <property type="protein sequence ID" value="KAF0724924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WET0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013582"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF589">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE [ACETYL-TRANSFERRING]]-PHOSPHATASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="6">
        <location>
            <begin position="262"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="7">
        <location>
            <begin position="337"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0724924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="642" mass="70506" checksum="D713045B344B64B4" modified="2020-08-12" version="1">MEMRPSEEQTTMTIDEESLDMEIDQGAEDPPPTLRSSSDLALSGSIHDTLSDGDTGSSLALAMDGDFKKRRSSTIKLQPRAPQSHLKPPQFVPRRHSGLSRISRKTDIAKNAAEELAKKMHPIVLKMTIHTDQDIRTSFVISNDQIHCGIGRNPSNAISIPADKYLADIDHAIISYVVHPIHGPGYYITPGATETNGTYIRLSPCSTDDVAAKSQWPLEVGCQFRAGKSDFEVLSTGPASMQLGVLTGKLAGKVFTINATGATIGRSADNTIHTGDGELSRRHAAIWYDGSKFYGQDLGSTNGTFMKLCGAYEHPYRLEIGDHILVSQTCLSVNRFDFGAYENMGARKQMEDAHSTIQDMNISALSCIGLYPQSFFGVFDGHGGYEASQYIHENLHQQIIKELQIRGDALKHCQSHDSIHAIVKEGITVAFEAIDSEFLKTSNRPQAGSTATTVFIAGQIAYIANVGDSRTVLSRSGTHIRLSNDHKPSRPDEAQRIRDTGGFIIHGRIMGELAVSRAFGDCEFKTYETYACQTTLKLEDENGVEQPVVNPNDILKGPLVISTPEISILEITESDEFLLLASDGLFDVFEDQEAIDFIRRELLEFGDVQRTVESLVDYAIGTQGSRDNVTAIVVMLKDIWSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WEU3</accession>
    <name>A0A6G0WEU3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_015738</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000231">
        <property type="protein sequence ID" value="KAF0725887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WEU3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018715"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF288">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="110"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0725887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="730" mass="82639" checksum="2002A1FF8E05907B" modified="2020-08-12" version="1">MGTETLTLQEASAFIQQVLSESRLETFNPWNSLVECGHAILHLCLQFHMTKECVRTTGVMVSRIVQAVLDATSPESGDQHYHILAYVFTSLHDYLKATWSASDDIHFNPDDESTWLGRGASATVYLGKYQDKFVAVKKFKPTSRSSSNSMDLERAIRKEIKAWRSVSHEPFILTLIGVCTKVTSPLLVSEYCPDTITRYVYMHPEKIVSVVYQLALGIRTLHKYGVILRDLNGRNVMVREDGSVAIADFGLSRSTESVLTEYSNTRNFVGTLNWMSPEQRFSPRKVSVQSDIWSFGMTVWQLLSDDTPYRGYSPEEIEEAIKSEDERPERPENLSEGNEFLWHLAQECWKLDPKQRPTSAQIVDALECHYRVGGGQSVQRPNREDSVTAKTNMRKLYEESLDDDFVYGNQVLAESSQNGMSSSLEASALNTLSAPSVSSWMDVDRHSSKHAADTYYENDWTTFEPAAIQSELFSLVVTVRKGKPVVSSDVSSACKSVRQCLADRDNEFQNEEITIWMGTWYLGESDLSNIPNGATDRMIKSFAPLGHDLYVLSIQDALNESVFNSTLQYLNSQGRAYYRLDLRNDQFLFPNKTASVNAMFDSIHSRAQGFRLLKKATVLAVIVAEDRRSNVSLLRAAVHKFNLVSGTRGGVAVALKVNQETLCFVNCNLDSDWTPDVRRKRIRQLHRKLAQDMGHASFDLTEQFHHLFWMGHLGHRTKRKLSSPGEPCHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WF60</accession>
    <name>A0A6G0WF60_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_015689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000230">
        <property type="protein sequence ID" value="KAF0725919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WF60"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005013"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF73">
        <property type="entry name" value="PROTEIN PDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="1">
        <location>
            <begin position="68"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0725919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="249" mass="27993" checksum="B5D238C65C13B1DB" modified="2020-08-12" version="1">MRLRARPGESFSVHREAIEAGRTWLKKVTSEFSRANTFNFDETALYYSAFPKRSICSQAMSGFKNDKSSLTVGLGANADGTEKLEPVFIGKSKEPLCVRGAGGFGAIDLQYYDAKKGWMTGKIFQAWLERLEEQFKAAHRHILLLVDNVSSHRLSSVQLEFVHVVFLPPRTTSVLQPMDAGVIAAFKKTYKGRQMEVALERFSNGVEVSKCFKFDILEAMKMSKKSLGSPQSQHNIKLMAPHWYSSGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WFE3</accession>
    <name>A0A6G0WFE3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_015595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000226">
        <property type="protein sequence ID" value="KAF0726082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WFE3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010733"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010734"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026003499" evidence="2">
        <location>
            <begin position="21"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0726082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="573" mass="64520" checksum="DFAD6CFED3500488" modified="2020-08-12" version="1">MSLAYTGLFVLKFASTPLFAYLTEPLPWSVPERTLTTWDSFDAFNNATFSYLASLYNSHTMPDATNVCRFDSATITFVARHVLELPVTSVPSTSSMTYLVQIPGAMFFSPGLLQFVSTFLSANATTRRTSRLSQCQRNYYFGVVSSDSCIWLDPLPVVESSSKDLYMAYYGTYVWEGASWSWFKVTFRCLLTIYILTVLWRRYCSHYQSLLVGLREIGLGDQYSRYEVIVGDPTYLILSNPLVSLVMVVDIVLGPAYITWSILRVCQFQDLLALFLGCFYSSRYVWCGYLAMRILSYAVHLRGWESKFTPIDPGVLGLGAFLYGGPVMTLFGSTSLMVLFHATWKLFLPSEPHIDTIEIAAGMVTGFFVMAGLPVVYSLAAQQLSKCQPQLFRCMRGSSARLASLGSTIRRKQSDLMSQTMPTAAAVVPKAARLRHPSWVGEINQTYIHSRRSFNDAKNRVLFAIMRRISPEPVHQIGGSLHHLYDRSPQYRRVPLFSCRAADCFVLCYLPDGMAHLQIRLSFLDCLDTRRNDPPMAIAICTTQHNAYHATCNVLKCATFEPKLASTMCILMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WFJ5</accession>
    <name>A0A6G0WFJ5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine aminopeptidase S33 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_016245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000247">
        <property type="protein sequence ID" value="KAF0725228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WFJ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005522"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051044">
        <property type="entry name" value="MAG_DAG_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11614">
        <property type="entry name" value="PHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="1">
        <location>
            <begin position="84"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0725228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="354" mass="40213" checksum="BB8F23F3FFCD75B5" modified="2020-08-12" version="1">MWGLEALLPASPIDIAGRALLVYLTIQMLKKLYEWSNPKNEPSRAITHAYDPHGAPGHRHYRFSADRKLWLRTRWWLPPGNTPWKGVIFVVHGYNEHIERYHYCASKLASSGYAVFGIDHQGHGLSEGERLYVERFEHYEQDFIEFVRDTLSLTSESAHVQESMMHFPEGLKLASLPRFLLGHSMGGLVCLRMIHKYPDVSWNGAIMCSGAFTLDPKSISPTDDFFSSILSVIFPKARPPNPSIKVVTDPREQERSIRDSFNYKTGPTMRWLSEFIAAVKAAAQIMPSIKIPLLIFHGELDVLTCPAGSAMLYDRASSPVKEMHLVPNVYHELLHDICRDDILDQIVAWCAKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WHF5</accession>
    <name>A0A6G0WHF5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Endo-1,3-beta-glucanase btgC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Laminarinase btgC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ae201684_015212</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation. Active on laminarin and lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000213">
        <property type="protein sequence ID" value="KAF0726590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WHF5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004095"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF17">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE BTGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026224426" description="glucan endo-1,3-beta-D-glucosidase" evidence="16">
        <location>
            <begin position="25"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="467"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="275"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="497"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="285"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="308"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="357"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="511"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF0726590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="597" mass="61178" checksum="B7AF5663A7694A63" modified="2020-08-12" version="1">MTWTPKRIFVIVLSAAALAASVEGAAGGVCFDVVDVPSIDAHFRNIKSKFSAVRTYQTQMGDRNAIQAAAQAGLQIAAGVWIRSGDDTIQKDINAIAAGIKQYPGTVVAVYVGNEDLANGWSEDMVIAKVNQVKSALGNTGVPVGSVQIDGDFLKADRLAAACDVVGVNIYAFFGSSPDSVSKPINDLDARWRAITSKFGGKARLTETGWPTSGSINGHIGSYDNAKAFWNAYSDWSYSNGGGTPFYFQYKDIPGKSPEYEAHFGLTDASGTWKFDVAPSPPSTAAPTTAAPTAAPTAAPTPPPTTQPPTTTAAPTTTLPPTTTAAPTTTVEPTTTVTPEPTTTEAPTTTLKPTTLIPITNSSNSTDVIVGTNSTDGTNSTDGSNSTNTTETEGFVTESALNSVDAVTSAGTADGAVLSDAAAGTSDAAAAAAGTSTDSTSGANSAGKSNEINVSAADTGSSGASTGIFVGVGAAVVVAATALVVVRRRAQALGEEDKNDFDPEFGLDMPPTQSAGSSQAQFGAQPEHAVAAAALPAEQDRESNIFNAKESLAMLEDRPSAFPETTDVAPVVDERDTMDLLDNHLNSAQSSSTEVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WI44</accession>
    <name>A0A6G0WI44_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_015023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000205">
        <property type="protein sequence ID" value="KAF0726881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WI44"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0726881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="141" mass="15611" checksum="032FDB44E9AF0458" modified="2020-08-12" version="1">MCIETSPAVGTSTISLCLCEFHAAKRREVHAAFRRRLEGSLPNADSERRFVPNPPRLSSSLLSHSCSLVVFAALHPLNIRSPSGRKRRSKGEINGAMGNSDDEGVALDQNERPRHSFSRERWSPGQTPALFRARSDVTKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WIM7</accession>
    <name>A0A6G0WIM7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_014827</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000202">
        <property type="protein sequence ID" value="KAF0727090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WIM7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004719"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0727090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="93" mass="10228" checksum="424E7B4E8E074CE1" modified="2020-08-12" version="1">MVALEIHTQAYTEHDVNSINKPMLYVPSPVVTSAPSSWRAPTAMALDAATNAPMSPRYCEPVRAKKSTRSSFRHALISDASGRFGRVAIRDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WKB5</accession>
    <name>A0A6G0WKB5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ZZ-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_014336</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000191">
        <property type="protein sequence ID" value="KAF0727712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WKB5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003845"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641:SF19">
        <property type="entry name" value="NEPHROCYSTIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00381">
        <property type="entry name" value="KINESINLIGHT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="348"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0727712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="506" mass="57892" checksum="F33897AF24C2CAC2" modified="2020-08-12" version="1">MVMSPWNDPVTLKRTWCVFEVYASVVENACFEIAMGRSQKASLIQDIQSNGAFREMLSTIKSEKSETTVPSDRDNIFQLIRDEVGFVELDRMVFDVMEKWMLRSVEHEIDAAPTTEIQADWIMVKGNLLHDKGEYAQAAEAFQTAHEISVESLETIVLTQIEAIYEETLRHEIRLLSKDHEDTLGTMNNLGGIYSRQGKHDVAVSLLMECYEGRRQVLGEEHQSVRSTMTEISMVLDNQNRLNESLEWSRRCFELQKRVDGEDHPETCRIQNNLAITYLMFGDFASALPHMKASYESLRRTLGQDHSTTLVIYANLGNTYRLVGDYTTAELRLLDCLDSQQSKHSGKSTSPRYLGLLYLSTHELDKAMTYYKEALAIVAAMHGRTHPIYARSLPPMFTIKMEMGCFNHLEEIAAFERELVDTQWTQDSWKDSMACHGCRREIHGKLFACSQCPPHALRFCHACAELNKPAAYCKHGADAIESTKPPQRYLHEQRLNILAKNSNWVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WL26</accession>
    <name>A0A6G0WL26_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_014108</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000184">
        <property type="protein sequence ID" value="KAF0728002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WL26"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014427"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0728002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="111" mass="12443" checksum="D304DF8AFC897BF8" modified="2020-08-12" version="1">MQHDGFRKRDYHQIRLTYFRIRGSRRDEECTSTPLSMVYGMTKAIAMAARPATTPEAEDLGVVVGAEVVVVELEDEPGAAVEDVEFDTEEYLLAIDNEKIAFSTDLSQSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WLZ2</accession>
    <name>A0A6G0WLZ2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_013862</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000179">
        <property type="protein sequence ID" value="KAF0728311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WLZ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004791"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012368"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06548">
        <property type="entry name" value="GH18_chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026303280" description="GH18 domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="3">
        <location>
            <begin position="25"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="423"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0728311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="541" mass="59651" checksum="D3C50F1FEE484AF4" modified="2020-08-12" version="1">MTGIAKSALIALALAMASPAEATKYKNVVYYVEWAIYARNFNIFDMDWSKVTHINYAFGKPTVNNTVAITDSWASLEKKWPDHGDSTTDSGNNLYGNLGQAFKQKLQNRGTKMGLSLGGWSLSDQFSRIASSTESRKTFVKSAVKLMEDVGLDFIDIDWEYPVEGGNDIPHSPDDIANLVLLLQDFRDEFKTLPFKAELSVASPAGPEKYRHWDFPAICGLLDFINIMNYDFSGSFSNYTDHHANLYLDPNHPPGDKFSAHRAVQDYINGGCPSEKIVFGIPAYGHSFENTTGLYANFSQPTNGSWGGLGTWDYKVLPQAGATEYYDEKVGATYSYDPVAKTFISYEGPKSLAQKLDYIKKYNLGGTMFWVADADLPSTNPRSLITQVYNYFGKENMAFYDNNLNYPTSQYDNIRNALTTAAPTTSAAPVTSEVTPAPTSTTTSTDAPVTTTETPDYPTLPTTTDAPVTTTETPGYPTLPATTKKAPTTTPKKTTTKAPRTPKPTKDVCRGKNNVCLVPGTRQSVDYCQTDCEKLSFTWCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WM46</accession>
    <name>A0A6G0WM46_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tryptophan--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ae201684_013767</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>tRNA(Trp) + L-tryptophan + ATP = L-tryptophyl-tRNA(Trp) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9671"/>
            <dbReference type="Rhea" id="RHEA-COMP:9705"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78535"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000178">
        <property type="protein sequence ID" value="KAF0728403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WM46"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011060"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000007">
        <property type="entry name" value="Tryptophan--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000033">
        <property type="entry name" value="tryptophan--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000738">
        <property type="entry name" value="WHEP-TRS_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055">
        <property type="entry name" value="TRYPTOPHANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00458">
        <property type="entry name" value="WHEP-TRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00991">
        <property type="entry name" value="WHEP-TRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51185">
        <property type="entry name" value="WHEP_TRS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10 14" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WHEP-TRS" evidence="16">
        <location>
            <begin position="2"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="42"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="60"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF0728403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="528" mass="58968" checksum="FD84649CCDB882B7" modified="2020-08-12" version="1">MDAPALEAAIVAKGDEIRQLKSNKQDFQAQLAELKQLKEDYKTATGQEYKPPAAPKAAKAPKDEKNPEGEKKADGEKSKSQLKKEKKLAEKAAAASAPKEKTQPKKPAKPSPTGRPEGGAALPSPAQLIMRQAKYAHHTALHGTSGGQTVTPWEVEAEDGVDYDKLIASFGCSSLTKDLVERIERLTEAPAHRYLRRGYFFAHRELNEILDLYEKGQKFYLYTGRGPSSGSLHIGHLIPFTFTAWLQKVFDVPLVIQLTDDEKFLFKDQTLEESEKMAWENCKDIIACGFDPKKTFIFRNADYIHTMYPEILKIQKCVTYNQVRGIFGFSGSDNIGKSAFPAVQACPSFPQTFPIPFSGRTDLRCLIPCAIDQDPYFRMTRDVAPRIGYQKPTLIFSKFLPALQGASTKMSGSVAAATVYISDPDEVVAEKVRQYAFSGGGETKADHEKYGANLEVDIPYQYLTFMLEDDAELAHIAEEYGSGRMMSSVVKERLIQLMVETNKAFQAKRAALTDDDVREFMRVRPLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WMT1</accession>
    <name>A0A6G0WMT1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_013608</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000175">
        <property type="protein sequence ID" value="KAF0728650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WMT1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002192"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="452"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="570"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0728650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="640" mass="71363" checksum="F22CFEA08E78532C" modified="2020-08-12" version="1">MGGSGRNMTWLHQLGNLLVKIAGAFAAFLVVVDVVYNNWELINYLGNAQYLLTPLLNHPSLVDVAASYAFPKEASPALLSEAGRFQLNDTITAAFGRNPDYYFLTAGGDLIQDASYDICGALAKSYPNVSATAATVNLGVVTNSLFYVRSTTLSNFFGMTATDVAPPKSNDATLTALGYAPARLDTDMKLTTPLAIPPSGTNMTANVTMYRFFPKSFCTGCSSSSAATNAASSTPYIGDTHLLGVILERSSASKASLYVRWICVFLAMMGYKASQKTIRWTDANVQTPWYKRLLYIFSPPLYRYSSDTYSLPDFFLNSDVVVFGYTVAILLDEKQSMVFTRQLAKWVQANDGWAQIQLFAIQFRWLWLNCAVLKCIKWFINFMSLTRQTGKNPFVGMCNFSSVIYVYLGAVFLVTRTSFIHYGNSDSVSMSATTDCIDTVRLDLFQSQYIRAFPSLILVMIVNLMAVLALDHVLHFRWWRRLKKNLLGRQAMYNSTSIFTDPPRRFLRARRWFLTYHTTSFGLVEETRQVRAMVTKVCNMKTDRTATGGAAIVPVRRGLSGQSLLNNPMATLPSDMSGQTDVSTKDADDKDAPANDMLKEMFLLVQDSDGNIRLYDSRKCEIQALSLEMKILRNSKIILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WN90</accession>
    <name>A0A6G0WN90_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_013390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000172">
        <property type="protein sequence ID" value="KAF0728820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WN90"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000466"/>
    <dbReference type="OrthoDB" id="58180at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0728820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="117" mass="13198" checksum="8FF1BFF8DAB7021B" modified="2020-08-12" version="1">MYSQTMHGLQAYSPAAAYSMQDDSHLRQRSSPVYSYSQQPRAYVPYASPTKYHHHSSDEEDFYLEGHGYTIVPTVPTPVELTSYEYGRTPTGRVLVTSGNQTVEFFSGVANCPLYMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WNK6</accession>
    <name>A0A6G0WNK6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_013258</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000170">
        <property type="protein sequence ID" value="KAF0728956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WNK6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019425"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050935">
        <property type="entry name" value="Bromo_chromatin_reader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880:SF225">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN BET-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880">
        <property type="entry name" value="FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="210"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="332"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="499"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="752"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="868"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="147"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="440"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="599"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1011"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1114"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="463"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="625"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="641"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="681"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1011"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1050"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1085"/>
            <end position="1098"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0728956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1159" mass="131478" checksum="EFF8E37266728B10" modified="2020-08-12" version="1">MSAESPTNKEKERISNHAHAACEQVLGHLLGHASLRNPDLSSWGKTALLEGTFLDVEALPSDVKAKLTRKCMGLDVVQKMLGSKPSRCRFKTVDKFSKDVRFVFQNILAWQAYVKQHQPSAYDELLQQTAQRLLQGFDMMYKGELARHASGAQQQQQGAPPPPSESPPPPPPPAASPTPTPTNGQTPRLNESDTQKCLGIVQRIIKHKEHGLPVAAPFLHPVDLTMYVDYKVKIPHRMHLFGVQQKLSNAAYVKLEDFAHDMRLIFANCLVYNSEVFLSVKIRDHAVKLMHLFEDLMNQTFDQGGNTWHGMPQPDRWKCHDIIHNILAHRTDGVETAQWFKHPIATYYASADQAPYNYFKVIKRPMDIGTVTSRLHLGEYTEVASAVKDLRLVFDNCIKYWKGHPDGQIYRDAAKALLSMLQSNVLSAFGPTYSGLFEKSSKSKSSSSTPAPEAGKSSATTPVHKESKKSSSRREFAEKDNCMKILELIRQHKMKGVMGEILTAGPFLHAVDITKYPDYAQIVTEPMDFNKIERKLKSNRYSSVSEFSADVHLIFSNCMKYNSDPVEGADIRTMATNLRDYFVSLYKELESGRDIVVTKPPPTVVLTKPKKTSSEPVAPPPAPPAIVLTIAATTLDSSSDKKHKKEKKKKKDKKKEKKEKKKHKHHHEDAPVAPPPPPPAAVVDLTSPSKVSSRKSTSSSSKPSKHKVKLDLAPWEATCERLVSRILKLEFVAAMHFEAPLAEKLPDLAKIYREIIPEPMDLGTLRNKLIAHEIPDQVEFVRLGRLIFDNAKTFNAGPDAASIRVRETADHLRWLFDSLCVEACVIDDADARKQWRNDRFTAVQTLKFVENRPNKECLKVLKSLTSQKHVKDTWPFLEPAATLFKDLPPTYFEIVKQPMDLKTIAEKLNALTYKSYGDFIADVRLTFENAMLYNQLDKDKEGWTIYGAAKKLYELSTELWGDVTIDVVERVRRSVMEHKEAQVEMEKSRAAAEARAVIEEAERIKEYQAKLEQQKKDEAEAEERAAAERAAREKLAKEARSKEMLASLSKSERKLEERRRKRLKKEEEAAQKEKRSRTAAMATEDALREAEHRSRLRKKALEIQKQREARELQARLDMQNVVRKPLDKRKPPPTSNGTFWKIKRRKVAEPAIFVDDDQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WPI3</accession>
    <name>A0A6G0WPI3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_013016</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000166">
        <property type="protein sequence ID" value="KAF0729267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WPI3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014988"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.120">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39200:SF1">
        <property type="entry name" value="AUTO-TRANSPORTER ADHESIN HEAD GIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39200">
        <property type="entry name" value="HYPOTHETICAL EXPORTED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0729267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="328" mass="33869" checksum="8C06A20ADC993493" modified="2020-08-12" version="1">MAFHTKFHRTFAAASTITSLVANLGAVYVTADPAITHATASLHYDSPDVLEAFNISESRHEWTLGWTGGKRVTGRYTIELRLPARTLECVSFTASGMLAISSGVLAASPSVHLSINSSGPGQLNIQDDTLVASGLTLWHTGSGSLQLTCRSIAADVVDVTSRGWGVVALCTSRLATTDLSVANHSSAVIYIDARTRAAAHDVRVVNRGSGAVRMAFDSLTTDELMLVVASSGPILLSVSAALNAARIDSRVTSSGSLHLACSPAGSTCAAHRIAMPGSGDLSTNVEAATTETNASGSGCVRQTAPCTVQSLGSVESIKLLPLSHPLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WPL7</accession>
    <name>A0A6G0WPL7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative auto-transporter adhesin head GIN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_013039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000166">
        <property type="protein sequence ID" value="KAF0729293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WPL7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014966"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.120">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021255">
        <property type="entry name" value="DUF2807"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39200:SF1">
        <property type="entry name" value="AUTO-TRANSPORTER ADHESIN HEAD GIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39200">
        <property type="entry name" value="HYPOTHETICAL EXPORTED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10988">
        <property type="entry name" value="DUF2807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative auto-transporter adhesin head GIN" evidence="1">
        <location>
            <begin position="221"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0729293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="372" mass="38868" checksum="7D74D9E50300B88B" modified="2020-08-12" version="1">MADSDLTTASGWIERYFNLKTKLEHLFVYVDAVHITAESGRSSPTIIVRASSSSILDMIDVVPTPELSAVSISQKSTVGFLVGRCLVEIRVPLHELRSVTRQTSGTLVIHPNVLSRSKETPLSIRCLGSGNIYIHDEEIVAKRLRLHLSASGRVQVIAKSISVVDAVEVQNRASGQLAIVATSLFADAVVIDNSASGKALIVVKSDLHVDKTVNVTSSGSGSATLAANAFVAGDLSIATHASGSTHVAGTTLQLSTVRTLVSGSGNAILSGSGKCETHSITNTSSGSVLVYGIIANQCTAESRGRGQIKVPSLQALQISSVASGLVGPHDNPVGPPLPEYSPQPLPDPSPASFFLVGFVGSSSHNLQLDDMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WPT2</accession>
    <name>A0A6G0WPT2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_012894</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000164">
        <property type="protein sequence ID" value="KAF0729392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WPT2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002001"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0729392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="178" mass="20015" checksum="9CE3EC2D85E090C4" modified="2020-08-12" version="1">MLSYDNEDQSAKRVSTTLLSPTSVGELRRDIARSQRRRHRVTFSTATTFEFPVAFGASALPKEREPSVGMTQIHSNMYMTDISNDNTECKRGIEMKLANLERMALLKAAAVDAHEIAAYCREAAEIRQSRQEAAHEEHRARRRKREAASALLQLAGYDIVEASSTKRHRVLHVTNSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WR71</accession>
    <name>A0A6G0WR71_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Annexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_012540</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="domain">
        <text evidence="4">A pair of annexin repeats may form one binding site for calcium and phospholipid.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the annexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000159">
        <property type="protein sequence ID" value="KAF0729901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WR71"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006136"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001464">
        <property type="entry name" value="Annexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018502">
        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018252">
        <property type="entry name" value="Annexin_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF102">
        <property type="entry name" value="ANNEXIN B11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00196">
        <property type="entry name" value="ANNEXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00335">
        <property type="entry name" value="ANX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00223">
        <property type="entry name" value="ANNEXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51897">
        <property type="entry name" value="ANNEXIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0041">Annexin</keyword>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0111">Calcium/phospholipid-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0729901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="330" mass="36590" checksum="56223A9F8DC86679" modified="2020-08-12" version="1">MLDLYTKEAHAVNAGQTVAVESVEIDNICHEIKMACAGIGTNEDKLTHLLGSKSASERYLISIRYGQLMGNTLVSEMQSETDGDYGKLCALLAQPLEDAEAMLVRHATKGMGTNERLLYPVLCGRSAEELSILKKAYFRLYAQDMAVVLADDLSGDLRKYFLAVMNIHPHPYNPTIHTDAKAVEIAEVIYKAGEGKWGTDESTFFNTLLSIPHQFLPKVDKAYKEKHGNNLTRAIEKEFSGKCEETAAFGIGMILSPIETVADLLERTMKGWGTDEYGLSAALVRYQPFLKDVAVVYQAKYGRSLRDRVYGETSGDYRNLLITLIETALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WRA9</accession>
    <name>A0A6G0WRA9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_012574</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000159">
        <property type="protein sequence ID" value="KAF0729935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WRA9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002623"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03213">
        <property type="entry name" value="ABCG_EPDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001480">
        <property type="entry name" value="ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF139">
        <property type="entry name" value="PROTEIN SCARLET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="446"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="470"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="506"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="590"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="40"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0729935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="616" mass="68448" checksum="24D77BBA8605E7E2" modified="2020-08-12" version="1">MATTKMDEHYIAIQTPKVGADILVDVPKLTLEWKDVNMSVKIKNQVTKQVEDKQILREVSGYATPGHLVVLMGPSGAGKSSMLDVISGRNNNFTGSVTVNGQKWTKAMNRYASYVMQDDIFYATLTVKEHLMYQAKLRMGKTFNAVEREARVDYVIDELGLTKCRDSQIGGVADVRGLSGGERKRLSFATEILTNPSLLFVDEPTSGLDSFMAESVVLQLQKLAREGRTVIATIHQPSSELYTLFDQLYLLSGGQTVYNGKASEAVDYFAALGHQCPTYMNPTDYFMRQIIVLDPHSDAATRVDGLVKAWKSHNSAVVESGFTLELPDDSKTYESSHLGVCGQLSLLCKRNVTRLVRDTLGFKARVGQTLFIALIVGLIYLQLDMDQAGIQSFSGAMFFVVINQFFSNATPEFAGVPMELPIMIREYKGGLYHAWVWYFAKNLSELVFQIFFPMLFLIPVYFMVGFGGNAGVFFTFYVFFVLIASSAVGLGYMVGCIARRPEIAQILGIVIILPLLIFGGLFLNANNTPAYFSWLEYISPLKYGYRGISRAFWNSVESIPCSPDSPCQATNGHQVLLNMALNKGSMGGDIGMLLAINVMFRTIGVVWLWLNIRQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WS16</accession>
    <name>A0A6G0WS16_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_012220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000155">
        <property type="protein sequence ID" value="KAF0730217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WS16"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002414"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0730217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="17143" checksum="B1354F3727DA9AEE" modified="2020-08-12" version="1">MNVKPCKTYKTWYEHFIVLEKADITNPRYEWKRIADEAEVEIFRGSDPYRPTSATLFCSTVDIAGTIDEVANFYTTRTRDETKEMIDRTELALLDAADLYTIHESQDLDIRVQWFLEKTPFDVVGKKRDCVFLKTRMALADKRGFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WS36</accession>
    <name>A0A6G0WS36_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_012240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000155">
        <property type="protein sequence ID" value="KAF0730237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WS36"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013717"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48472">
        <property type="entry name" value="TC1-LIKE TRANSPOSASE DDE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48472:SF1">
        <property type="entry name" value="TC1-LIKE TRANSPOSASE DDE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="147"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0730237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="260" mass="29762" checksum="2887E109C545B3E1" modified="2020-08-12" version="1">MSTAEEKRRVLEAFNQGNLDWKEVAKYNGVSLSTARRVVLNQRVQVLPRGGPRLASTRVTHEMRQALERYLNENCLYTLRQMQQFLVFDFNGVKISLPTISRHLIGMLFTMKQARVEPSTCNSDVNKSKRQVFALKLLEHQEQNDYIVYYDKTNFNIYCRRSQGRSKKGTCAVVVLPPSQGPNLQVQCAVSLADGLVCHRLERGRILMDDNAAFVEKIYQSVKSSDTWQEHYQGKKVVIVLDNAPAHSQTEVRSIAHDDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WSA1</accession>
    <name>A0A6G0WSA1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_012322</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="VJMJ01000155">
        <property type="protein sequence ID" value="KAF0730324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WSA1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019164"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="3">
        <location>
            <begin position="613"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="187"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="196"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0730324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="972" mass="108997" checksum="7CFF4186D17CDC7B" modified="2020-08-12" version="1">MCRYLFPRERVENGHIGTSAILLVRKLGEEYINGYSDVILRAFKCNHDIQILIGGDEMAERIYYACKYTTKDQQKVECRTALALAAFDVRTQRERSALDQGEALSDEMKCRRRLASHMFNMTRKQEVAGPMCALYLLRESCAYTSHMYKKLSIHQVLKFLHHHSDTSYSLEMTSNLPSIPEADHIFGGGDYSSSDDNSESDFSDLESEDESPVETPTNTNMRVFVPVGPGEDYINRPVMCADLSWYEYTSKYFRGNRTASTPDDKLFLEQHSLYGSKCLGVHRLARIPVLTGGVRIPYFEDCTKNDQKEYHAQLALVLFKSFRAITDLCPTDSTWHESWEAFQPMMSSLCKEVYHYMEDYHVGRKKAARTRISREEEQNIQVEIGDGYADDFDDIDLENALRLGVEGPTSNNLDLNGIVDARNELYQSVPSSELRNNVIFPTTIPISGSCAIDALLDGTSLDEAAAITTSKYLSIVGNCDQRQNCRQVLASDIRSLKQWASKKPVERVITFEIPTEINDIDVMTTEGNPNAHVDVQTMVQLRIPSALEVSTMLYSGRVVERGNIPQSLPDFSHIGYVSDAFGHTIRQHLSFVTIARALLLRWQLEKTLDHDFDRVQEAISAIQLRMVLHGEGGTGKSHIAAVQAFCDSWKRPFSIAKTAMTGNAAVSINGVTLRSWIGMHNLAPSTVHEAKEAEEKGLPGFTEDLKLLLVDEMSMMNKQYLVRLDEELRARTKLDIPFGGINIVLAGDFFQMPPVGGKPMYTPLSAPNADMKLDLYEDSGFSLWRSFRTVVDLDENVRFAKDPEWGRLVGLARKGEWTQDLVDILNSRILPQGLILNDMKPNPCSASDGSGTKRCTTYTTPDNRTRQAIINAYTAALSKKLPVNHYPIRIVANFNGLLNDLSSMDVSRIMSLPDTKLGNMAPFIDLIPGMPVVFTQNVNPQQGIANGTFGTLHSVQFDEATKFKLVQDSGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WU66</accession>
    <name>A0A6G0WU66_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_011598</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000147">
        <property type="protein sequence ID" value="KAF0731049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WU66"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018489"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050441">
        <property type="entry name" value="RBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48034">
        <property type="entry name" value="TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="52"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="131"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="134"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="149"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="182"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0731049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="195" mass="23051" checksum="9AEB2D65468CCBF8" modified="2020-08-12" version="1">MGRRSNSSPSTSRSRSRERRDSRDSRRGDRRDDRYRSRSRGRDSHDDRPIPQSLLVRGIPNSVTIDVLREKFSRRRGDIRDVYVPKDHATGEPRGFAFIEFKDIREARDVKNSMDRTKLDGAEISVIFAQQRRKTPDQMRRQELETRGSSRKSQRHQRRSRSPSRSCSPSEKHLRNRNRSRSRSDSPVRRYRSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WUX8</accession>
    <name>A0A6G0WUX8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_011386</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000144">
        <property type="protein sequence ID" value="KAF0731323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WUX8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013690"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF201">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026271406" evidence="3">
        <location>
            <begin position="20"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="487"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0731323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="536" mass="59915" checksum="827CBA370541E819" modified="2020-08-12" version="1">MWPLAWWLVLHVAAALAAAGPPPKNPHEIESMPGYNDDTAINFAQFAGHIRLQSTGQDMFYWLVESTSNPSLDPLVIWLHGSGDPGCSALNSLFTDVGPFVVQSDLRIKRNPYAWNRRANFLFVESIAGVGFSRPMLNATEYNDEETAARMYEFLQEFLAMYPTYHNRQVYLFGQSYGGVLVPYLVEKLVETPIESFVLAGFAVGNPFTDNQIDASATLDYFYTHGLISISMYERGRDACGVSGASYCFYGGGECPQECLAVLLEGQASSQAANAQAFNLFDIFGDVCSLKSNLKLEHHAIRPLTHRGMMGPCVDLFTSKYLQRYTVQRAIHIQDRHVNWEKCNRHVTAKYTRSRSVLSKYPAVLRAGLKALIYTGDADAVDNFIGTERWIQNLQLPVREKWESWFGPDKQLAGYSTRYTNLTFTTLKGAGQLVGATRPLHALYMFECFIYGNIVCATFSYPTDDVEYLSGADLTTNPNKSQSGGALIPWAITAVIVVLGSIVGLVYWTKREERSQYIDWVVETSRSDNRSGIGYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WW85</accession>
    <name>A0A6G0WW85_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Glutamine synthetase</fullName>
            <ecNumber evidence="3 10">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_011034</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 10">
            <text>L-glutamate + NH4(+) + ATP = L-glutamine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 9">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="3 10"/>
    <dbReference type="EMBL" id="VJMJ01000140">
        <property type="protein sequence ID" value="KAF0731731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WW85"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013518"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.70:FF:000004">
        <property type="entry name" value="Glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.10:FF:000004">
        <property type="entry name" value="Glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050292">
        <property type="entry name" value="Glutamine_Synthetase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852">
        <property type="entry name" value="GLUTAMINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852:SF57">
        <property type="entry name" value="GLUTAMINE SYNTHETASE 2 CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51986">
        <property type="entry name" value="GS_BETA_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS beta-grasp" evidence="11">
        <location>
            <begin position="21"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="GS catalytic" evidence="12">
        <location>
            <begin position="108"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0731731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="356" mass="39453" checksum="560495921882303C" modified="2020-08-12" version="1">MSKLDRDVYDRYMSLSTGNFIQAEYIWIGGSGEDLRCKTRTLEKVPSSPEELPIWNFDGSSTNQAPGEDSEVLLKPAAIFKDPFRGGNHILVLCDCYKPDMTPIPSNTRFDALRVMKAAASHEPWFGIEQEYTLFEADKVTPYGWPKGGYPGPQGPYYCGAGAHSAFGRLIADAHYRACLYAGVRVSGINAEVMPGQWEYQVGPCTGIDSGDQMWISRYILLRVCEDFGVIVSFDPKPIPGDWNGAGCHTNVSTKAMREEGGIAKIIEALEKMKLKHKEHIAAYGTGNERRLTGRHETASIDQFSYGVANRGASIRIPRSTEAEGKGYFEDRRPASNMDPYTVTGRIIKTIILDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WWZ3</accession>
    <name>A0A6G0WWZ3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_010749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000137">
        <property type="protein sequence ID" value="KAF0732096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WWZ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002241"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03199">
        <property type="entry name" value="GST_C_GRX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011767">
        <property type="entry name" value="GLR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007494">
        <property type="entry name" value="Glutaredoxin2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011901">
        <property type="entry name" value="Grx2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02182">
        <property type="entry name" value="GRXB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007702">
        <property type="entry name" value="PRK10387.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04399">
        <property type="entry name" value="Glutaredoxin2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00195">
        <property type="entry name" value="GLUTAREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="39"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0732096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="259" mass="28629" checksum="2272EDBA0E59B196" modified="2020-08-12" version="1">MASKSVILGVVGGAAAGLGLGFAVASKALAKKATKKSLLKPRVYIYDHCPFCVRVRMIFGLKGVDVELAPLANHDEATPIGLVGSKVVPILETPEGVVIPESMDIVRYVDSHYGGKSILAEADPSREDLKKWIQDSAECMRHLYHPRFHAGFLPEFAQEASRVYYKTKKEKSIGSFEDAIAKSPEYVAQLNAYLVQLESILKKPHSVNDTLSYDDIDLFGRLRGLTIVKNVVWPPAVREYIDHFSRVCDIPLLDSIAQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WXG1</accession>
    <name>A0A6G0WXG1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_010837</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000137">
        <property type="protein sequence ID" value="KAF0732188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WXG1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002032"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="635"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="606"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0732188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="749" mass="80976" checksum="51267E1ECAC83811" modified="2020-08-12" version="1">MSSDESDSSEYDSDVSSDEDSDGSQEASSESGESVEEDESDEDNQKPEEDLAKSKAIADDMAAIYRLSNEMDKICRRLQFRYSLKQEEEPAKPVDEPQKAAMPSKSDATTDSDDLPVPRKGCSTDAAIPRCREKAAPPTLPFQDALSKSIEDKTKPKPVHGTIAMECRLQMEVKASPDFHLLEYMKPPRPKSLPSPSRSRRSISKPKDGMNDDPAASPSKTLQDREPPSHVAVTTDTTKSVTRRKSSIKSTSNLQVESTNAVSPVAKQSSRQGIPSPQRQMSSRKEARGVRPEPVEPESPEVMKTAASTSPSQQRRRSSTRGSNDPAANAQVESLTSQDQSTSPLKPRASVASVAPLPQSIEKVDGDMEEDDDMMDLGDENEPPPPQDMNEDDGDVDDDGDEALPPQEQDDECIPFSIAQQEELDHAAAEAADEDDFAQSEHGDEALPDQDTSLASDADNRATSVPAEETPSSDDQRVETPIPTEVPIVSTEDESLDDAPRRHDDEPIATTSILPSSSELPAAVTASSDPLPPTQAATASTRMSIVPEAKRPSIVDPSRKASMPPPLEETTPTLPIDRREPSSSLPTRRSTVVDSPAQVHGMDSIAASTAPSARLPAAAPPLEPVISPVASTAQYDTPVVESSAEQSPVPSRRESFQRAARRASSIPKVAVTVNLPTSPISPPSRRQPSLYDSLERPTTMENAFQVKSPLLSHLRSSDNTTSFKPSFKQPSIEYEVHAMHYLLFGPPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WXT2</accession>
    <name>A0A6G0WXT2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTP cyclohydrolase II domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_010596</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000135">
        <property type="protein sequence ID" value="KAF0732307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WXT2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016337"/>
    <dbReference type="OrthoDB" id="57939at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="entry name" value="GTP cyclohydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022163">
        <property type="entry name" value="GTP_CH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005536">
        <property type="entry name" value="PRK07198.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47259">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47259:SF2">
        <property type="entry name" value="URACIL-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12471">
        <property type="entry name" value="GTP_CH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="RibA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP cyclohydrolase N-terminal" evidence="2">
        <location>
            <begin position="38"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="GTP cyclohydrolase II" evidence="1">
        <location>
            <begin position="256"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0732307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="457" mass="50580" checksum="D56D9EAA7317C6AA" modified="2020-08-12" version="1">MASLKKVSTLGKRKKSIDAEDVKQIEEKDLFDPKSVYVSLTSHAETFGVEPVKVKWGHESPDARGPIIGTNRHDKYRNAIGAHGGSYCIYRGLAVASGALDKTSHPDLSKTTPAAKIGPFPSWGDPEKIVTIDPFGHCVLEAFPEHFEKGYDIRPTIAVTKAHMDMQEIHEAVRLGRLKPDGKILKESCQLVITKAAVDPVWYLPGVAKRFNTTESNLRQQIFQETNGMYPELVTRNDLKIFLPPIGGLTIYIFGDVAAITDPNKKLAVRVHDECNGSDVFGSDICTCRPYLTHAIEVCVETAQQGGAGVIVYFRKEGRALGEVTKYLVYNLRKRQEGGDSAAEYFNCTQAVAGIQDVRFQALMPDALHWLGITRIDKFVSMSDMKYDAIVKSGIEIVERVPIPKELVPQDAQVEISAKVYAGYNGGNVFEKLDKDALKEIKGRGNEDYEEDDAAME</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WXU8</accession>
    <name>A0A6G0WXU8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Ae201684_010619</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="VJMJ01000135">
        <property type="protein sequence ID" value="KAF0732331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WXU8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002017"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16702">
        <property type="entry name" value="RING_CH-C4HC3_MARCH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000287">
        <property type="entry name" value="RING finger membrane protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13145:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCHF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13145">
        <property type="entry name" value="SSM4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="474"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="509"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="570"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="631"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="670"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="792"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="837"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="880"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="914"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="15">
        <location>
            <begin position="2"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="227"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="335"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="227"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="351"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF0732331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1095" mass="124004" checksum="444283B2D83CBF04" modified="2020-08-12" version="1">MGDSSDDEECRVCRGEAEPGRRLFAPCKCSGSIRFVHSDCLTEWLAISKKEVCELCGHTFAFQPVYAEGCPKTLPTRELVWSVLVVAIKKWVPFVIRGVLVAIAWLVIAPWCTSWLYRLWLLRAATMGTVNFNDRVQKYDLIFDDVFSGIILVVVIVCSFLSLMSFADFLRFNMDQMVEEPNEEAELRHREMLVAQEMEAVEMVARIRGPQENVRLIERIDGVDEWIADDSEDGNSDGGSDDEADDEADDEADDDAADAEPEVDAQARGRRQPHILAPLAGFRARQRAAFPAQPRRLRIRQQDNLPLFDEVIQHIPHAAVFRPHIARNVRPDPRIVEANQENRNNRRRAAPARNPAAAPGDNAPFPANNEWEDDFDHMEINIAMDEVIGFRGPLYILVRNVSWFLAFNGAYLGIFAFIPYTLGSTIVATFGKFVQFVDIPLHGPVEEMPVVYRFVGMAINTTEAAQSRGDCLQFVDVLTCAVGYFAFCGTIVMWRVLVNTISMYAHRQVLSGLLWFLSCLNAVVKVGTLLVLKMIVMPMVLGFGMDFATLQLFMVSPWERITFLMEHMLAALMIHWVLGISFMLFVTVAVLQMREVMHPDILAATVRPQEPNQDILKSMLAEPSIKHARRFILSVAIYAVLLTLLVYLPVRLMFAAAPSMFPLQLNFHYIFAHAQVPLELVLAHMAVLNILDTYKHEVGYFQSMWMTTLCRKFGLVEYLLPRVPSVPGSEEDSLILNVPPLSLNQANDHPPENERLYGARYVPWPEDGLVDPTMIEYNLLPRKYPSHIPLRLTMLLVCCWWTTVVIIGAAALGPLFFGRLAMAMVERSSGIRHDSLNFAAGIMMMWVLVNGFKVCRVFLIHEKDIHPQLRSRGYSVRGMTLSSLITLVFTWGVLYPIMIGIIGALVFQSDSTPSFLEMHCFGFVVLHVGAWFACCFRLNKQRPRNQPPNQNAEQWADDRWEELRQAEPSLLNSFRLAYEEICFHLRAHDDGVEHDQDLSARCFDAANFMEHVVAPLGFAMAVCIVLPWLCSKAHGHLGWSHLSETHVFRAAFATQVLGLLTIASKAQASRWFSALHDSIRDERYLIGKELKDMAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WY75</accession>
    <name>A0A6G0WY75_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_010461</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000132">
        <property type="protein sequence ID" value="KAF0732472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WY75"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013785"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14295">
        <property type="entry name" value="PAN_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026023630" description="Apple domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="2">
        <location>
            <begin position="26"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="2">
        <location>
            <begin position="244"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0732472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="742" mass="82269" checksum="D4002D6055896A70" modified="2020-08-12" version="1">MLRAVAASLMASWVFSNEWKALPNDTDYIGGDLNSTLRASISDCAEDCAATRHCWLFVWSHRNGGTCFLKERTAAASHVSLPGIRAGELVQTEPPPSLFKRNDVQGNVFATTDVQVHEAGTFPLPTLVFHSMAQAMWANDLPEALVTAKISNGQELFNESLLVHHDLATPFHHVESISECARIAFAYTRVFFTYLRQSQLCILVNSTREKTSSVLNLATREGHPMPAWDNSLPSIFDRASGIATSSLACSSACTADTSCAASLWNAATNNCTLFAPRKALFDDIYAGWIAPPAVIRSPDSVEPYALVRNALSSSDSLFEKQDAAGMSATDCAVRSAQQGQLFFAFDEQTQTCRIAKTQSILAHDDASATSFLYWTPTAPIKLHGALAEDVIPRRQSRHEDVAGCTSACIPSFELCFGSLWLADKKTCYIYLPNVAAANASNHSFLGWIAKTPQSLHVNDEEFPAPSPDHVHVFISAHQDDHELFMSADVMHALANPHAKLVFIYTTAGDADARDGWWEARESGTLAASSTLVELLAEPSFNSRRKTSLARVGRFHVRRTDVGDRLRHYFVRLGEESMFKFALDNATNRVEKPLGNDNHEEEDVYTSLDDVKAVVRAILRDETYGFPSVVVGANEFHGLDAADQGVDHQLHEATGAITASVLETYPLWAQCVHQKYYFGYQRWQAQANIPEPYRSFQRYMWLQLSAAIDARYSKGYPVWMDHIHVLGRQYIAREVLNTTFPCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WZW5</accession>
    <name>A0A6G0WZW5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_009896</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000126">
        <property type="protein sequence ID" value="KAF0733074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WZW5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011814"/>
    <dbReference type="OrthoDB" id="147163at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008701">
        <property type="entry name" value="NPP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33657">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33657:SF6">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05630">
        <property type="entry name" value="NPP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029958">
        <property type="entry name" value="Necrosis-inducing_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026357557" evidence="2">
        <location>
            <begin position="19"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0733074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="259" mass="28360" checksum="9A4060104A93CC9D" modified="2020-08-12" version="1">MKTSILVAFAAVANVVSGLDLPKLDQALPLNVDISAISPVIDTDTDCCLPSAAISRTGEQNEGLKPTGSVTGLCRNSAFLNYSNSYHRYACVTSGGSKYCGHFFAYYFLKDQLFPLVESGHRHDFEQVVVWTINGKATHGTYSTHGDMVTAPESEIPKQDGHLKFVYHKDGVQTRCFRFAKQNEVAENPAGTFVLPTVVSWYTMKGDGIDNAGIRNKLNSYDYGSAHNPTKDGDFLPNLNEGKPSTFPQFTQESVDNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X0K2</accession>
    <name>A0A6G0X0K2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_009624</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000122">
        <property type="protein sequence ID" value="KAF0733375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X0K2"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030626">
        <property type="term" value="F:U12 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045164">
        <property type="entry name" value="RBM41/RNPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16105">
        <property type="entry name" value="RNA-BINDING REGION-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16105:SF0">
        <property type="entry name" value="RNA-BINDING REGION-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="330"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="73"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="199"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0733375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="427" mass="47306" checksum="2DB3A0308C0F20E5" modified="2020-08-12" version="1">MQWKLLVKNLPSALSTHAIEALLQHVGAVHIRVLVNKNKKKSALAEFPNEAVLKTALTRLNKMRLADHQISASIYDKTQNEDESTPQTDARNDVPSEPNEQVKSSTPAIFPPLPPDPPPPIHHPVQSTPWLQPAPLAPHLGLHYPPSPLLEYKYPKASHDTIVNVANALLALPKFYTQVLHLMNKMNLPPPFHPDAIPGPFSTHFNADKKRKRETTTDEFIASDEDEDDKDDHAEETAASEVISITAADATAVSSNRKPAKRVAPSKQLRYNPTVNIFHKDDAAASSSTMGHVPRPGVISEAELNRTRLPPQELSQLKHMQGYSENAASEVLYVKNIAKSVDVSDLTYVFGCVFADDTAMEAMKVKLFQEGRLKGQAFIEFPSIELATMALRLVHGVVLDEKPLLVCFRKQQPRPPEKPPHDDNKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X2F4</accession>
    <name>A0A6G0X2F4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dynein heavy chain, cytoplasmic</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Dynein heavy chain, cytosolic</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">Ae201684_009249</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Consists of at least two heavy chains and a number of intermediate and light chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000118">
        <property type="protein sequence ID" value="KAF0734080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019815"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000003">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002141">
        <property type="entry name" value="Dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000001">
        <property type="entry name" value="dynein heavy chain 2, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000044">
        <property type="entry name" value="Dynein heavy chain 5, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.20:FF:000010">
        <property type="entry name" value="Dynein heavy chain, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000003">
        <property type="entry name" value="Dynein, axonemal, heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000049">
        <property type="entry name" value="Dynein, axonemal, heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000320">
        <property type="entry name" value="Dynein, axonemal, heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054354">
        <property type="entry name" value="DYNC2H1-like_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532:SF4">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532">
        <property type="entry name" value="MALE FERTILITY FACTOR KL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08385">
        <property type="entry name" value="DHC_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22597">
        <property type="entry name" value="DYN_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="12" id="KW-0969">Cilium</keyword>
    <keyword evidence="11 17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0243">Dynein</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="13" id="KW-0505">Motor protein</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="18">
        <location>
            <begin position="1913"/>
            <end position="2050"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="18">
        <location>
            <begin position="2177"/>
            <end position="2305"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="18">
        <location>
            <begin position="2505"/>
            <end position="2656"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="3158"/>
            <end position="3224"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="3381"/>
            <end position="3457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF0734080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="4626" mass="526878" checksum="5747ED94B8745370" modified="2020-08-12" version="1">[encoded data, 4626 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X2I9</accession>
    <name>A0A6G0X2I9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nucleoporin NSP1-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_009188</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin NSP1/NUP62 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000118">
        <property type="protein sequence ID" value="KAF0734015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X2I9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013930"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000040">
        <property type="entry name" value="Nuclear pore glycoprotein p62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026010">
        <property type="entry name" value="NSP1/NUP62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007758">
        <property type="entry name" value="Nucleoporin_NSP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12084:SF0">
        <property type="entry name" value="NUCLEAR PORE GLYCOPROTEIN P62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12084">
        <property type="entry name" value="NUCLEAR PORE GLYCOPROTEIN P62-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05064">
        <property type="entry name" value="Nsp1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin NSP1-like C-terminal" evidence="10">
        <location>
            <begin position="329"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="85"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="203"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="270"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0734015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="516" mass="51353" checksum="BA3A18994F2B4B1E" modified="2020-08-12" version="1">MSFSFGSTASTAPSTGGFSFGAAPSSTNTSSGTSATTGFSFGAAASSTPAAAPATSGFSFGGASTSTPAATTGFSFGSTPAASAATPAATSTSTTPSFSLGGSATPATTAPAASSTTSTTPSFGFGGAAPSTTTATAPAAGGFSFGSTPAASTTPAATTTAAPSTGFSFGGASTTPATTTTTSSTPAAASSFSFGGASTAPAATSTTPSFSFGGTSSTPAASTTPAATTSTTTPSTSGATAAPASGFSLGGTSTSSTSAPAAGGFSFGGAKPAESSTTSTDKPAATTSGFSFGGSTSASTTTTPADGKSTFTLGGNDNKDATAVTAQDKPPAEYMDKTVEDIINMWSEQLESHAMAFTNEAVRVSHWDTELMENQKKLGDLAIDVRRLQVSQKELNANLDTIASYQTELESTLENLESSVDKMFESHRQIPDAADLEREQTLQLSVDIDNQLNMMSTALKETIERLNQSQAENEAMDEPLAQILKVLNVHHNSLQWIDENATKLAKDMGAIAQKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X2M6</accession>
    <name>A0A6G0X2M6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AN1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_009021</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000117">
        <property type="protein sequence ID" value="KAF0734153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X2M6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003297"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1110.10:FF:000001">
        <property type="entry name" value="Zinc finger AN1-type containing 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050652">
        <property type="entry name" value="AN1_A20_ZnFinger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002653">
        <property type="entry name" value="Znf_A20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10634:SF149">
        <property type="entry name" value="AN1-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10634">
        <property type="entry name" value="AN1-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01754">
        <property type="entry name" value="zf-A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00259">
        <property type="entry name" value="ZnF_A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51036">
        <property type="entry name" value="ZF_A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="A20-type" evidence="5">
        <location>
            <begin position="4"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="AN1-type" evidence="6">
        <location>
            <begin position="83"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0734153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="149" mass="15980" checksum="BEAD4C046E770946" modified="2020-08-12" version="1">MQQEESAALCSAGCGFFGNPAHHGMCSVCWKKRGAKIPADAPTVVPSSEPVSLPQPQVTATVALDSTTNEAVQDTQEPAKPIQSNKGRCWSCKKKVGLTGIECRCGYVYCGQHRFADQHDCSFDYKAADMAELAKRNPGGGAFNKLDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X2Q4</accession>
    <name>A0A6G0X2Q4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VHS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_009058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000117">
        <property type="protein sequence ID" value="KAF0734192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X2Q4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019152"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009411">
        <property type="term" value="P:response to UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018610">
        <property type="entry name" value="UVSSA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28670">
        <property type="entry name" value="UV-STIMULATED SCAFFOLD PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28670:SF1">
        <property type="entry name" value="UV-STIMULATED SCAFFOLD PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0734192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="337" mass="37590" checksum="4965CB4BC5882783" modified="2020-08-12" version="1">MTPNDAASALEQGMQLLKKRPTKRKRQTNEASTPEAALEQIKKGVRYSSDPSAASRNVVAAVLSALDTVPPPLSMIVQICRSLFERSKAFRNELVGQLRSMCHRLEIKQLYNVEILDMLQAWDTQYGAVYPQLRAAVAAIPAKWTALQRKRDDAIATAASSRREIEEVRAIQFDHMMREVEAGEAAIVDHIESMERTCAMLVPTVEDCFSALLPAAKYAPEDDDDEVWEDVLLPPPIDSWSLPDVIESCGLGSAAYTISIPVPDIVTPDDLELLHATLQEQVDEIERRFQPKVQSWIQTARTRPASAILHRLEKLQHSLESVLAKAKAFNKPSNDNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X467</accession>
    <name>A0A6G0X467_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_008728</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000109">
        <property type="protein sequence ID" value="KAF0734657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X467"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010100"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000008">
        <property type="entry name" value="2,3-dihydroxybenzoate-AMP ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF5">
        <property type="entry name" value="MEDIUM-CHAIN ACYL-COA LIGASE ACSF2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="56"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="500"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0734657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="609" mass="67620" checksum="BA97D2DDD801BD81" modified="2020-08-12" version="1">MLLRALRARSLQAATRHVSSLAPGRFARIARTFATFTGPQHPPLLDCTIGQMLDSIAEKHPDQLALVAVEENVRLTYSQVQEKVDRYAQALHWLGLRQGDRFGIWLPNTADYYLLQWATAKIGVIMVNVNPAYRAHEFEYAMNLVQCKAVLVTPEVQTSHYFDMLNTLLPTLASHDTTVTSSGVVPLNLPQLPHLKYILHDAASRREPGMIGLDELLSVAPHKPLDPTLLSSVTPDQVVNIQFTSGTTGSPKGAALTHANILNNGYLVGHRCGYSTKDRVCVPVPLYHCFGVVLGNLACLAHAATVVYPSKSFNATKALRAVENEQCTSLYGVPTMFIRMLNDPTFNLEKMKSTLRTGVMAGAQCPVDVMENVLEFAPEMTIGYGMTETSPISFQTSREDALMDRVETIGMLMPFTQAKVVDMEDPDVEVPIGKPGELLTKGYCVMKEYWNQPDQTRKSIVDGWMHTGDIVTMDERGYCRVVGRSKDVIIRGGENIYPAEIEEVLFTYPDVTNVSVIGVPDREYGEVICAWVNLSGSKEGRDLEALQEELRTHVRNELAHYKVPKYILFKDDFPTTITGKIQKFKMREISVDELNLADCFTTPASSSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X4L4</accession>
    <name>A0A6G0X4L4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_008565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000103">
        <property type="protein sequence ID" value="KAF0734903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X4L4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020325"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033194">
        <property type="term" value="P:response to hydroperoxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005583">
        <property type="entry name" value="YaaA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30283:SF4">
        <property type="entry name" value="PEROXIDE STRESS RESISTANCE PROTEIN YAAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30283">
        <property type="entry name" value="PEROXIDE STRESS RESPONSE PROTEIN YAAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03883">
        <property type="entry name" value="H2O2_YaaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0734903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="227" mass="25140" checksum="66BD73C4A4A9DC74" modified="2020-08-12" version="1">MLIASGRYKNFVTDVDETQKPSELFKQAVFAFDGPAYKGLQSDSWSDKDIAFAQDHLRILCGLYGTLRPLDLIQAYRLEMGQKVSNPRGKDLYNFWGCTISEDINKAFESSSASTKILLNVASIEYFKSVDLAALDPSIVVVDCVFKDDGQIKSVYAKRARGLMVHYVVKSQASTLEDIQAFNMEGYQYSAKESTSTTLVFNRSKAALKRAVEAGKAPGGAKKSRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X4W8</accession>
    <name>A0A6G0X4W8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nitrogen permease regulator 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_008446</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NPR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000102">
        <property type="protein sequence ID" value="KAF0734973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X4W8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004996"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009348">
        <property type="entry name" value="NPR2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991:SF10">
        <property type="entry name" value="GATOR COMPLEX PROTEIN NPRL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991">
        <property type="entry name" value="NITROGEN PERMEASE REGULATOR 2/TUMOR SUPPRESSOR CANDIDATE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06218">
        <property type="entry name" value="NPR2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="359"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0734973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="421" mass="47175" checksum="AE43242E95081CD2" modified="2020-08-12" version="1">MIQGIFYSEFDNIAGPQIIYQAPPNALSNEVFDSVSGYIIIDKALCGKIITVCPQDIKIVGYPVCIEDDKYHRNALLFNIGFIFHKEADAIPYKPILRKLGTLMESMEKEMGFLSKESTKATLETILPSILSDLTLYGESTITIDPANIINLKVFQKLPPPPNVCDHEVPVAIRDLKDLLKNSVEWDLALQKIVPHIDGVNYVKRIAIVSEVDISIVKNCLRQLLYYGCITMIDIFLHSNIYATTSKIYDFFNNAALQQACLSYICKDDDSQPSFSTIFALYCALQPNAPVGHMWTSHPKLMTQIDLRRFITFGLIHGFLRRIHRYPVAIDHIARTQPLSSSPSSLNLAPSNLNSGGLPIRSAVKTTPPQHGATRGSPDKEKVKKMLDGEHNTDEICCTHMIRNSDLENMLASDAYCFVHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X525</accession>
    <name>A0A6G0X525_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_008291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000101">
        <property type="protein sequence ID" value="KAF0735078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X525"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004060"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0735078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="356" mass="40282" checksum="46EF832139796A2E" modified="2020-08-12" version="1">MERYFRYEAAGDRFTGRVATGLPINSVDLSILPPHFTNAPSEFISDTIAIVFPKLVSQSHLHGALRLLLASLVYHCDFIKKMLPFNHPLLSTALFTTHGFIESLRPMLFSGLNSPHLTPTGIPPFVELLRHLKLNQEAIELLPNVILDGVREIIDERGLASGNITREYFESTLSKALSTIAAGTSSNPVPSDCSTNRPEYDVHHWNGQLHMLPIDFKFPSVDLMTAWTLWWHGNPSQKVPSFKKINTRDLSLKTERKEFYEWRHIMNQLTSFYVSKTGHEPNVHSTTADLVEAFDVCKDLLAPISDMTPKNRKRRHSQLCVSTTARLVRQMTAPGANRPFQARKKTARDGPHKDNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X6C3</accession>
    <name>A0A6G0X6C3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_008028</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000095">
        <property type="protein sequence ID" value="KAF0735548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X6C3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019949"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026313849" evidence="3">
        <location>
            <begin position="19"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="268"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0735548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="353" mass="36291" checksum="F9395B01722747C1" modified="2020-08-12" version="1">MKALTLVALSLLFVVLQSAPQKNRPRHTGHNGPKGKKGGSIMLDMLDEDYGSSYGYGVRNIRSGFRLMPVGTTSGGFISKCAGFKLMPRPSCSYRGNFCTAYKLMPAGASQDSYDSNCDEYENKLTPKPTTKPTTTVPKATTPAPTDYYVSPTPEPTTYAPGYTTPAPGPGVYTTTPAPGEYTPAPATTPAPSSGPYVPSTGPSGAPGTGPSAAPGTGPSGAPGSYPSPSPGPPGSPNPSQGQGQHPSPSPGRGTTPAPTTFPPGHTPPRTTTKAPTTTVGQENNYGNNGNSTKQSPPLSTGAIVGIACGCAAACALAGGLFYMKSKQKKREEQMFTENHDLEDPAHTGYAAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X788</accession>
    <name>A0A6G0X788_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bulb-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_007768</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000093">
        <property type="protein sequence ID" value="KAF0735763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X788"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014487"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.90.10.10">
        <property type="entry name" value="Bulb-type lectin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001480">
        <property type="entry name" value="Bulb-type_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036426">
        <property type="entry name" value="Bulb-type_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51110">
        <property type="entry name" value="alpha-D-mannose-specific plant lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50927">
        <property type="entry name" value="BULB_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026023476" description="Bulb-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Bulb-type lectin" evidence="2">
        <location>
            <begin position="43"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0735763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="188" mass="21235" checksum="D5E4702B328B619C" modified="2020-08-12" version="1">MLLAPRFSTVSFLWLLLVVAVQVYGVCEYCKVNQFPVLISIEGSNHNGTNTLGFKSSIVTSDNALRLQMQEDGNLVIVDLRGSKPLPIWASMKFVKKGKTAEAVLDENGRLVVYDNSKNLPIWSSDFYPSFRTIQPFCVWVRSDQKHIGVSIMDSGCQLVWRAPLPSTKKEFQAFEAMWNAYNETSDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X7K3</accession>
    <name>A0A6G0X7K3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Winged helix-turn helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_007701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000091">
        <property type="protein sequence ID" value="KAF0735951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X7K3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013870"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025959">
        <property type="entry name" value="Winged_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13592">
        <property type="entry name" value="HTH_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Winged helix-turn helix" evidence="1">
        <location>
            <begin position="95"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0735951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="206" mass="24631" checksum="439689B3E13396D4" modified="2020-08-12" version="1">MSVLNHAVHHQHATSNTVYHALHGYYYGGRTTQELSAIYSKSDRTIRGWICRFEKEKEYRRHSKSHKSPFGEEERQWVKRFYDTMPLPFLDEAKAAFEEQFKRTISVSTIWRILREIGYTYKVLERRAMNIKMKDNSKRSLLHFVAEVVDNFRTFNMQSIFEHCGWTKNGCFDPRESLGNDKVKLPDDQQQDVYDLLNFVERDDYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X7K9</accession>
    <name>A0A6G0X7K9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 33A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_007594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000090">
        <property type="protein sequence ID" value="KAF0736003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X7K9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003997"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043155">
        <property type="entry name" value="VPS33_dom3b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0736003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="564" mass="62009" checksum="48CCB6A0363A0BF5" modified="2020-08-12" version="1">MPGKKTLLVDPSFEAFLEVLSRGGGGKAFYDSLDITQILYVGAASNLPLASCESQLVFLLRPVPVYVKMMQDIVSKCRRNTFLAAWLPQSNGVCTLEMERQGLKGLVREVDMPIFLLPCEDFVWSLCWEAAFHNLYLNHERSILTFVVQSLLHLESQGLALQRVSGFGEIGEQTKNLFDTVQAAAMKSRPSSSRPTVVIDHCILLDRLNDPISLLVTPLHYEGLLDAVMDMQHGTIVHDGKKRVLQDEFYTSIRDMDFDQLTTLLSEMSTSLHVELSDTKASSSSNSISSNAAVADILRKLSSLAKTKQDLSLHVDLGQAITKASQEDMDALRRCVETEHLIMAAGGSNSDAATIDTMLEEALFRVPPLELTKTLKLLCLPCLVVGGFKQSALDRWKTQLCHTYGYTTMIPLLDTLTSLQWLFVKGSHSTWNWSTSKKRLDALVNGNAIANDIAFMFSVTGYAPLSVRTVQVAVGQRRLSGVNLPTASSASSLSTVSSASSSSSSSSKTKQTILVYYIGGVTVAEIAAFRFLNRVQDNYNFIIATTAICNPTRLLQSLGRQDKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X7V0</accession>
    <name>A0A6G0X7V0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_007574</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000090">
        <property type="protein sequence ID" value="KAF0735980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X7V0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020594"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="14"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0735980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="356" mass="40353" checksum="9E2AAF3ED23DE135" modified="2020-08-12" version="1">MASSQAANTALHALKDLDVMVSSMVQTHGRFGRVQYIVQVSERGKGHYVVPRRYKSFRDLYMRVRSIQSASRIVLTRFNSFAVSKWQALSMLQFPPKTCFLNGLSSTAPGVLHNRLSFFHDYLTALADIIRTYNWRENATIYNAISRDQALQLSVIVQHFLAIPEAFGRADYYLHNHPVCRAADTIYCHLYPVIQENWTPVWNPRQNSPPPPPQPTQEQRIPHGRPGSNRIGRAASVSTNPPQHAALRRRIKVHSLKRGNGSRSKHVMAFVDESSQSHQSTTVSDITTEPRTNDHHEVNEYDHVQRGHHGDNDDDDDDVPLIGDSDSIVMLGERVDFRSHVKRRGSTGVVGGRFYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X9C0</accession>
    <name>A0A6G0X9C0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_007110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000088">
        <property type="protein sequence ID" value="KAF0736660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X9C0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016952"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="654"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="654"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="666"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0736660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="676" mass="76878" checksum="2B048A1D2F74C2BE" modified="2020-08-12" version="1">MTTVAVERVEPIAEPAAELDVSINMVEEAMKEFKCQACFEMFQLNEGMTEICSDTCPAIMCTTCMSSYLTVCAESAPRGILSRLNCPICIRPVNMHRLQRKSSGIFDALDLFRTRVEGACEMLCPECHESCNLLEESPTYSNALEGLTNGPDTWPNEVRNEAMDDLPTVYELCQRYLTNDMTVDTFFGELVKTAFVGPFVGKVSRLLMSYIYDAERRVSLFLALMKHDPFEHTPCCSRPVCFTCKRDGHHHGEQCQAYLPSVEDMAQCSSCDLVLVKGDGCSSITCFCGNQFEWEPAVQAYRLKILTTEALTTKRSVWQRVLFYLRGQACRRRLTLMVISQIPSFVLQQRLNNMSPALFYPPWSTSFRIDLNKCMDRRRIAKQTAANRLLFLDLVVSQISTVVNQWRLQRINMAMAAETPWKCSLKALINAKVTRRRHAKITAENRQLFSDLVVAQIPVAVELRKLQQITMAMATSTAWKKSLKALVATYWSRRRYSSMIPLVAVAQAKRVEAKTRASFQLVHADIASAVAAKRWAKLEPQRMIVLERTLCRWVSVRRIRIAEVHARRRQLMKIVATIPGLIQLRQQELLKRQEETALAVEEIHDQIPMAIDMQHTQRLSRASNAFHHAIVSKAAAISARYRELVEPIDLPPQSISLERMPSSNEPPERNRMPVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X9H4</accession>
    <name>A0A6G0X9H4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_007172</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000088">
        <property type="protein sequence ID" value="KAF0736725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X9H4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010816"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0736725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="400" mass="44771" checksum="80AB9764720535E2" modified="2020-08-12" version="1">MSTSVVQESKLSENAPMSMTYTSNQDEEPSVIPIAFASRLLSCVDRQDQWHLKLTSAQTARDLECDEVWELVGLERFRLPSSCHGQWLQSCTRRYQALNDAVALCTYMQRQNVFSLSYINRDIKERIQDQLLSIIDLTSSGLDIVSRIYLAQRGVVKHLGRLLGSNTMAISDLACAALANFVCVLSSKDESTIRAQLIESVEQVRGTRGLKELLLSPLVSESGPGPTKHAARVFINMLFPQHQVICQVRDVWEGYILTEPALRPSVDEDLDHLKQLDGVWDISYRHCSGQDYNHLVIETAATPRGDIHGSGRDNKGQSIKLTGTLTSKPGVHNCEFSVTFDNQGKPYGPRPILHIGFWSSLHRDRIWGVWEVRTSPDQHKLGTGGIFLIKVQQAQTSQGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XA22</accession>
    <name>A0A6G0XA22_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_006784</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000085">
        <property type="protein sequence ID" value="KAF0736972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XA22"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008727"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008728"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0736972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="183" mass="21355" checksum="FCB6EB4533C3ACB4" modified="2020-08-12" version="1">MSENEKLKNELEGQIQFGKALQTLMTNRPQLTMLPTLQSDQWRVQKLVTDPVLRRQAIEEILHQQYQLTEFSMIESGFEDGEESLTSFTPRLARSTADLVMCAAYSKLFDFSVDIVSEFAWMMYQGRFKARKDMSFEVFEKHGNDSIYMRVNKMWNEFAIQGNSLYKRFPGPDRVVIVARGRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XAP7</accession>
    <name>A0A6G0XAP7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_006857</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000085">
        <property type="protein sequence ID" value="KAF0737050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XAP7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018587"/>
    <dbReference type="OrthoDB" id="7344096at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044159">
        <property type="entry name" value="IQM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31250">
        <property type="entry name" value="IQ DOMAIN-CONTAINING PROTEIN IQM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31250:SF27">
        <property type="entry name" value="IQ DOMAIN-CONTAINING PROTEIN IQM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0737050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="283" mass="32555" checksum="B8441A7489016D98" modified="2020-08-12" version="1">MECVSRLAMSRCTSAPPLDLLEKARKYSPTLVRGFSSGNISVVDKQSWLEVCDKKHRYGANLQAYYKAWKKRDEPKPGFWEWLDDESIEVEGVPRTKLERETVQYFDKAERQKFALEIRHGLIITQWDQQPVNTGDEGWIFVLRDGVLYGSEKVTNQVPRIHHTSLVGGECVQAAGMFVVANGELTIVYPHSGHYRPSENEVLLLLRFLHSQGIPLHNVQVDVQRIQKVSREKINGKKVKKTDCAFFWPGDKALDFLSAKELACLLHIFDSIERRDWHLKHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XBR0</accession>
    <name>A0A6G0XBR0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_006615</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XBR0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015745"/>
    <dbReference type="OrthoDB" id="125347at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF73">
        <property type="entry name" value="PROTEIN PDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="3">
        <location>
            <begin position="90"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0737453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="569" mass="64342" checksum="22E4ECD3B960DC8F" modified="2020-08-12" version="1">MPSTPEVAKVKARRGRATDGAGKGNLTVEQKRRICEKHRSTPKITQKDLCRWAMLEFQLAKAPTQPTMSNILKHEHLFRESVGGAAFDLSRKTIRPTKFNHFDQALANWVLERHNKVNLTGDAIKEKGRELSAQMGLEGKLAFSNGWLSSFKQRHGFKKLGMPKTNTSNPMVAMNLIDSTATALIPQVMDFKLPDELTSVHIKELTQHYALKDIFSMDETGLFFRISPHVFADHDNLEVHFAQESKLTVALTCNADGSEMLEPFIIGDLSPPKDWRSQSAEKLGFNYVHNAKSKMTVYIFQNWLRDLNARMQFAQRSILLLIDNAPSHIVVGLELSNVRLIVFPHTMGSKAQPMHCGITTAFKCRYRMKHLAHAIDRNEEGAPDIYSVKQIQAMQWISEAWREVPKEVVVNCWRKANFVAAYHGEPVTNVEVLEKSTEDDLWSMLYCLQLGGVINIKELLNSRGENDVHKQLNEEFFDEPREALDEFKALDNALSVSQAVTDVTDDATGAESLPTLQEHLDAFRTVIRCLETSAPDQDEAQTLAEVLQFLKKKQLGLRLNRASTTTFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XCE6</accession>
    <name>A0A6G0XCE6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_006205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000080">
        <property type="protein sequence ID" value="KAF0737809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XCE6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001328"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026145060" evidence="2">
        <location>
            <begin position="18"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0737809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="298" mass="31705" checksum="0FF90C97C15656E3" modified="2020-08-12" version="1">MKLIYLTLALTSSVGFAQDTRQCTQVDINLVQAAWTDEYGEKCLSKYQLTLGKLPTARASVLAKADKDDDCLTALLAQDNIIDEIVHTSGDCKLSETLSLYDTTFHEDNGFVTGWATALKELPCIDVTKVNTSLLLSTERDSLPDCTQNHFNLVDAAWGRDFGASCLTALGVCLSDFSKGNVSADVLATAESNPDCTTVLEHQGDIVDYIVDEIGDCRVVGNTSLYDLSFFNFSEWANVIKTLDDIDIGAPASSLPEFQLSSSAGGLSSDNSTSSGTASNGTTSTTTTTAPSTAVPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XCJ7</accession>
    <name>A0A6G0XCJ7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_005929</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0737933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XCJ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021108"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0737933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="319" mass="36361" checksum="879EF5A2281808D7" modified="2020-08-12" version="1">MQEELSPVEHENVKLKRQRQAMLNVITTMTKWISAAKDITRGPGSILHSASNMSLHLVTLSALNPDCRRHGLDWLTQILFQNTNAFLMRYAMEAQPPNCVYGDFHVDVSDLKNVQHIFQAQVDIPYDMDTVVDPVRVHVVDRLSALDVYAKSVTPIDPEIVQRVSPLMKYQRRVSQTGAATWAMNVLYREFQEPNRVTFVGQSVEDDKFERVPFSKRKSMTWVVVTRLGPSMTRVTFMSLSSLEYNDNIFRSLEDQARSYGFHLDGNDPMIAEKYASSMKVVGDPGVATYTAYLANVVQASKEREKAKDQEDFLSLFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XDD6</accession>
    <name>A0A6G0XDD6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb/SANT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_006011</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0738019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XDD6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019533"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024752">
        <property type="entry name" value="Myb/SANT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47072">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47072:SF4">
        <property type="entry name" value="MYB_SANT-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12776">
        <property type="entry name" value="Myb_DNA-bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like" evidence="2">
        <location>
            <begin position="10"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0738019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="294" mass="32888" checksum="BB0620D09F394405" modified="2020-08-12" version="1">MASQDGACASWSADRDEFLVRALLAQVSKGKRSDSGFKKEAWSEVTTAFNERFRTTYHTSKIKSRLDCVSYMIVDGTNNDQLKRDYKDAKYLRENSGFGWNQSLQLPTAPDEVWASMIKTNPYCKKFRYNSFPLFEQLSALLDGSYADGRFSSMPPGVEADEFERDVESQPLFAPSVVSTIEDNDESDESSDESTPPPKKKCQQLRKRDKRSAGAVIGDAISKLVEVEASKVKNNSDPHERVTLAIDCLMENYSHLDGMNIANLADMMSEGLNATIFIALRGPARDAWIAKKCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XDN1</accession>
    <name>A0A6G0XDN1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_006136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0738158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XDN1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001217"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027948">
        <property type="entry name" value="DUF4436"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14494">
        <property type="entry name" value="DUF4436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0738158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="144" mass="15099" checksum="6FB39069B6072DA6" modified="2020-08-12" version="1">MTLEITRDFNIYTALLFIGIWAVTIAIGYIGSMSVIWKRRPPDNPVIFVSALFAVPTFRNTAPGKPPYGCLFDVFSTYFSIGVIITFLLLVAFAYMKKQKKAGSGKDDDTIPVATLDAGGVAGDVADGGVAADAGVAADAGVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XE89</accession>
    <name>A0A6G0XE89_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_005672</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000074">
        <property type="protein sequence ID" value="KAF0738441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XE89"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016460"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30509:SF9">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN MDTO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30509">
        <property type="entry name" value="P-HYDROXYBENZOIC ACID EFFLUX PUMP SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="575"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="614"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="640"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="706"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="925"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="968"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1031"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1041"/>
            <end position="1054"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0738441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1138" mass="126749" checksum="1F761E6B257E3695" modified="2020-08-12" version="1">MQSPRRSPSSAPYAVVSTPQTPEVAMEPPILVHRASRVSGAVGSLRSLSLAPPRDSARARVSSLVSNKGGEGKMKINMGKERSLGTDVRFRPDFKFNMELALRTAVGVVLASLVMTKNHKNSAEASANGHQKQWYFFPDWYILGGLSYVATATVFGCGKNIGSTIREIYQQISGVGMAFLYNFIIFSVFQPQVFNTAAELRNATVNGTLLHITHAFSGSGYYVHQHDFYTILPFIMLFTLTTLILPLETNTKKYMLGNNLYFALTLVSPNDFTNPAVLKAAGDDFYKTHNILRNLAVYMMLGVMGACIAQLMLWLPYPIFAIRKLQEQTLTCADTIQELLNIIVDTYCFKNKDVEHMNFLKLKLKRKFDLAIAKHATMTALLGDVWWEQVVGLHIPLQFRFSAMKPFVDLFGSQIENLRAMNQAILLERYENLHDLFMKELQKEVYVVQLQATRLLDEVSADVHRGTTEMALKGMAPLEKHMEKLLTRFQSTQTRIYKRHKPTAKQVEGNIPLNLFLFSLQSYCSTLLEFQDTFNSKTHRTGKRMSKFLLGSLKAFVDKSKYPSDKIEMAFKVSFAILAACFFSVYTFGYSSTTAGAVAYVMGNHIGGSFSVTANRVGGVIAGSIIPSICLFYICSYACYSNLLVAISTYTILFVWVTMSMYIKWKGGFESYAGLISAFTATQVLLKGCDGCEKGSVAPISSYANLAQMSLGIVLFIIVEMVIHPQSALALLRANVQKQMKMYQQCYKALVEDTLARNGVVDVEDTSAVDEIKDIVKKKLPAALVEQAALLKEAAFEPLLWKPPFSQQKYEAVLDCCQRLLNNTLVLYKLTEWYKARRELKELRESLSATKDDKKTVPGAAALAAASDDKTKGDIVTVTTTAAAPEPEPWGFSIAEASRAIHDSFDTMHDLFGLNFTYADGDQTALFMQMKEAFRLADKDCSGEIDADEVKTMLEMIFAQSGAVKVDAIDTYVAEFMRIVDADGSGKVSLEEFIQALEHGLQLQVEVFQHRSKKVAPTTLLTTIQEDVSRNSTQNNDDAHQQSQQQQPSNGAPGVQRLSSQGLLDEAMTRAHDMLNVDSFSLPEIAQAMRTHYATWLLDTTRYESASMEELLLLNCLISGISGFARNLALLEEMSVQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XEF7</accession>
    <name>A0A6G0XEF7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_005687</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000074">
        <property type="protein sequence ID" value="KAF0738456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XEF7"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0738456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="142" mass="15967" checksum="EF20482BD69E9F56" modified="2020-08-12" version="1">MLTPKTRSYSYDCVDKPTCCLVFCSQSRKWLSKSLGDLEIGGVKAIAGFWISILAEDGGRIQFHDWTMALTIDMESLVVKDAIDSIVRTSRRIKFYNGIINPKMSTKRIISVAVVVFQPIARCCCAHANESLEMKAKQQRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XGG3</accession>
    <name>A0A6G0XGG3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pseudouridine synthase RsuA/RluA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_004921</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000064">
        <property type="protein sequence ID" value="KAF0739352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XGG3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010480"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF40">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE RPUSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="2">
        <location>
            <begin position="121"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0739352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="404" mass="45597" checksum="308F60CB17FDB140" modified="2020-08-12" version="1">MDSQARQTKRRKTDKAEETLKAEYEVRDGYRYVKPYVFKFQTYAKERWFGRTVINIFTTEFGSFSPEYYALAIETGRVTLNGARTTATTVVKNGDLLCHKTHRHEPPVSGETIEIAHETPDLLVVSKPAGIPTHPCGAYRFNSLHYILLHMRPNIPHLHIVHRLDRLTSGVVILAKNSNTARKLSACIADRTASKTYLARVRGTFPETLTETWLHEIQSQLSTPRATVTIQPDDATMLNIKCPLVCRSHKDGVWACADENDQDVKEAETLVQFHKRHDQDDTTVVLVKPVTGRTHQIRLHLQLLGLPIANDPCYGGVLHFGSSLASLCESPSVSAKTEEDDKIESDGLPQQDGESDDAFLERTCEWCASGRRSDNKNHCACIWLHAWQYELLGETYRVASPSWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XHC8</accession>
    <name>A0A6G0XHC8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Centrosomal protein CEP104 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_004837</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000063">
        <property type="protein sequence ID" value="KAF0739667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XHC8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001204"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.10">
        <property type="entry name" value="UVR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052607">
        <property type="entry name" value="CEP104-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048739">
        <property type="entry name" value="CEP104_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13371:SF0">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 104 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13371">
        <property type="entry name" value="GLYCINE-, GLUTAMATE-, THIENYLCYCLOHEXYLPIPERIDINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21040">
        <property type="entry name" value="CEP104-like_TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21038">
        <property type="entry name" value="CEP104_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centrosomal protein CEP104 N-terminal" evidence="2">
        <location>
            <begin position="374"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="615"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="243"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0739667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="913" mass="101342" checksum="FDF45859C2AA0D55" modified="2020-08-12" version="1">MTEGPCLLVGMQEDKKDEHSIEQLAQDVVNSLVSIGCRLVCIDFDATFLQIHTNGAWKESAQDLLQYVRPLFVHLLPLLAVVRPSVSIAVVTFSSQVSLIREVLSLCYASSLSDSIIIRGDDEAWTITHEEATDYTGIDAHHLSLSRRTKFPYVASAALEASRRDGLQPIKSCHTVLIDDCEDNVFLAIECGIPAIHYDSRHFPQRVQAEMKRRKRKSTHESTPHSAVRRLSIQSPPPAGDSSSKTTTTAIKTIRTAPSPTRSCTPSKERKPKPHFCTPSPVTKLRVSNSIGKPKPKRYTKLKTMAEETRCLEESDGKIIATALHTTDWQYCLHFEMGSGMTQIPFLVAAASSEDDEHPALHLQAHQATTSNQGWQSAKFCDYPQDLVLIVNHGKPVDVAKVELLIHQTKIPTQIELYSKDQTMPNYRKLGYVVVDSNKATQYQARELKTISLDCRAITSFKFVIQGCHTNILNVFSQVGIVSVALFGPQGMSKSPQSPKKPMDSQLSPVRTTMANQVPNDDPLDANLSSHQTTFRKVLERLREQRDKRIESEDYLAAKQIKEVEDQVLQCSHQLHQLQRQKLDAISRQDFDTASLLKDEIDQLAAKVSTSVQTILPRAPASHGSSRASSPRRKRQQSPPKNAHITLQPLHYGKSEPSIAEPMDAKLAEACQGIEAYVKPSILCQAFSQDEKLRKPAVRELVATLKALPQHDEAPFVWSTLLPWLRFGLAQLSYHIFSTACACTLATVATFQSSRELVAGAPSLISILIQRLGDNAAKARNKAGVVLLELANEKDGLGRQCILSNIVAFQTTAATPTNWRLLQNLTRVLTTLLIDFECPIEATDIRTMLSFIHGQNGFGHAQTSVCDATTQFIVAIYHRLGPAADASLTTYLSLSQRAEYKKMLADEWSIVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XI14</accession>
    <name>A0A6G0XI14_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Long-chain-alcohol oxidase</fullName>
            <ecNumber evidence="5 12">1.1.3.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Ae201684_004670</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Long-chain fatty alcohol oxidase involved in the omega-oxidation pathway of lipid degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>a long-chain primary fatty alcohol + O2 = a long-chain fatty aldehyde + H2O2</text>
            <dbReference type="Rhea" id="RHEA:22756"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17176"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="EC" id="1.1.3.20"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.20" evidence="5 12"/>
    <dbReference type="EMBL" id="VJMJ01000062">
        <property type="protein sequence ID" value="KAF0739784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XI14"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009671"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046577">
        <property type="term" value="F:long-chain-alcohol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012400">
        <property type="entry name" value="Long_Oxdase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46056">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46056:SF12">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028937">
        <property type="entry name" value="Lg_Ch_AO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="14">
        <location>
            <begin position="252"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="15">
        <location>
            <begin position="554"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR028937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR028937-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF0739784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="729" mass="79131" checksum="84137F6CDC4C7217" modified="2020-08-12" version="1">MPFTETHKATLSAIASAFLAPLSKEDSSAIVEEHIRELQDESTREDLESFLQMQTPDLGITEAMVSKLMYLPQDKQNDFRQVLDLLATGWGTFLLTGSSRGLPFHELSLAERESALLHLSKSNFSLLRALFRSLKGLVHMNVFATGSTVDGTMNPYWKALQYSGQPDEKPRPPRSHFWQPAFEDVKAMAKEAQGGKIVVETDVVVIGSGAGGGVIAAELAKAGYRVLVLEQGDFHHPSDSNYNESEEYAKQYVDSVFLTSQDNSIQMLAGKTWGGGTAINWSASLRPPQQVLDEWVSKHKLPYFGSQEYQQALNVVCARAGISPDCVKHNVPNQNLLDGCAKLGFHAETIPQNTAGAEHSCGYCSLGCPYGEKQGTHITWLKDAQLAGAKFITGCYVDKITYSSDKIASGVVGTVLHGTVAIEVKATTVVSCCGGINSPALLLRSGLTNRNIGRNMHLHPVTTVMGFMPKQEVKAWEGSIMTSLSDVVSNCHGDGYGARLETPTALLGATSGLLPWRGNNDFMRIMMQAPHLSGIVTIVRDCDSPIQVKLDATGRARVHFQLGKKDAVSMVEGMIASTKILLAQGAIEINTSHLSIPALRLETEQDRSNPLECETTKRWFSQLRSIGIPSNSLAIFSAHQMSSCRMGSSPATGAVNPQGESWEVQGLYVADASIFPTASGVNPMVTTLSMGYSVAQFIKANLDEERTSGRRARSSSSSFWENIGSWFSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XIK1</accession>
    <name>A0A6G0XIK1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GMP reductase</fullName>
            <shortName evidence="8">GMPR</shortName>
            <ecNumber evidence="8">1.7.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Guanosine 5'-monophosphate oxidoreductase</fullName>
            <shortName evidence="8">Guanosine monophosphate reductase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_004351</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8 11">Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8 11">
            <text>IMP + NH4(+) + NADP(+) = GMP + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:17185"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.7.1.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.1.7" evidence="8"/>
    <dbReference type="EMBL" id="VJMJ01000054">
        <property type="protein sequence ID" value="KAF0740111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XIK1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012195"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902560">
        <property type="term" value="C:GMP reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003920">
        <property type="term" value="F:GMP reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006163">
        <property type="term" value="P:purine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000012">
        <property type="entry name" value="GMP reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00596">
        <property type="entry name" value="GMP_reduct_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050139">
        <property type="entry name" value="GMP_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005993">
        <property type="entry name" value="GMPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01305">
        <property type="entry name" value="GMP_reduct_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003470">
        <property type="entry name" value="PRK05096.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43170">
        <property type="entry name" value="GMP REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43170:SF5">
        <property type="entry name" value="GMP REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000235">
        <property type="entry name" value="GMP_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01240">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8 11" id="KW-0521">NADP</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 8 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="1 8" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IMP dehydrogenase/GMP reductase" evidence="12">
        <location>
            <begin position="10"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="8 9">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="26"/>
            <end position="27"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="8">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="8">
        <location>
            <begin position="129"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="8">
        <location>
            <begin position="180"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="219"/>
            <end position="221"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="242"/>
            <end position="243"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="268"/>
            <end position="270"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="8">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="8">
        <location>
            <begin position="285"/>
            <end position="286"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000235-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000235-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0740111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="364" mass="38691" checksum="C749AB61B4232CF8" modified="2020-08-12" version="1">MPRIETEPKLDFKDVLIRPKRSTLKSRSQVDVSRTYTFRNSGKTWTGVPVVAANMDTVGTFEMAVVLAQNKCITCIHKHYTVDEWKTFASSHPDVLPFVAVSAGTSSSDLDRVSEVLGNHADISFVCLDVANGYSEHFVDAVRAVRAKHPHHTIIAGNVVTGEMVEELILSGADIIKVGIGPGSVCTTRKQTGVGYPQLSAVLECADAAHGLNGHVISDGGCTCPGDVAKAFGAGADFVMLGGMLAGHDESGGDVIEIDGKVFKRFYGMSSAVAMKKHAGGVAEYRSSEGKSVTVPYRGPVDGTIKDILGGVRSSCTYVGAAKLKELSKRTTFIRVSQQLNEVFGKAPNEQEIEASAAKKAKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJ96</accession>
    <name>A0A6G0XJ96_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_004235</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000053">
        <property type="protein sequence ID" value="KAF0740230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJ96"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016775"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF91">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PLK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0740230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="304" mass="33858" checksum="6DBEB338276CCEBC" modified="2020-08-12" version="1">MPSRYVPVRPFATPNVLLCRDTCMDMDVVVKRINDDVEETIYRSVHALGGHPHILPQLDCFRDGSATTSHLVLEYCPNGDLFDLVVANKRIGSSLSIVYFEQLASAVHALHTLGYAHNDLSLENVLLGRNMQVQLMDFGAAVSIHHATTYFGGKSNYRPPEVFTGHPWDPAAADIWALGVTFFAMLTGDFLLDDTVICDPAFDVLLDQGFRALLEQMPHWKALIPNAVVALLEQMLQVEPSARPSISTVVQYAKLLSSVISPGSPRHQQSTRHKIMRPRTLYRFNDIYARPTGPLPPTPFIHCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XK06</accession>
    <name>A0A6G0XK06_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_003912</name>
        <name evidence="2" type="ORF">Ae201684_003914</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000047">
        <property type="protein sequence ID" value="KAF0740680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VJMJ01000046">
        <property type="protein sequence ID" value="KAF0740713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XK06"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005809"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF37">
        <property type="entry name" value="2',5'-PHOSPHODIESTERASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="241"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0740680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0740713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="594" mass="66290" checksum="96F463C042DDE376" modified="2020-08-12" version="1">MQATMSRFLAHVHYHPGADSIKLQFPFQGVDRQLVRQVDEELSRVLVRIERIANPPMKRRDVKAAAKQQQPKATAKAVLKASAVIQFKTAANEVLPPTQSVRDAFLSATHFEINEDTYRIVHNQPRVKTITVVDTLFVGVPIVPTVDLDFATIDTCSWAWHRGDILLSSDFIYTPTVADTGHALTLTCTPPLSEDIASVPSADPVVLETPLIRATPDRSVFAPRQALGSQRVPDEVGCRIMTYNILCDKYARADREVNRMYPFAAPGILQEAYRMPLVVLEVLENGADLIFFQEMGEAICKSYFEPLFSHLGFHGQYAGKGGSTPEGCAIFARSSKFDLVDGTLVKFASCLDEMIKTDEALAAFLDHHPQVAASTKAVPSIVQLVTLRAKHNDSMVLAVNSHMFYRHDANIVRLIQAVLLAKIVEKRKAELEAEFQLPVRLVLGGDLNARPVTSSIVYLLQGYVDASHKDWIEAPSFQWGDDETYGLKKAASELPEMPTQLSHSLKWESPIQFPFTTYLRNHEFAFQDTLDYILIDPTQWKVLQTFPGFTHEEVDHEKSLPSSTFPSDHISLVCDVAFVNSTDKPPLATVYNQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XKV8</accession>
    <name>A0A6G0XKV8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cilia- and flagella-associated protein 263</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_003633</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CFAP263 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000041">
        <property type="protein sequence ID" value="KAF0741061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XKV8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005645"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051885">
        <property type="entry name" value="CC_CF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025254">
        <property type="entry name" value="CCDC113/CCDC96_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15654:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15654">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 113-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13870">
        <property type="entry name" value="CCDC113_CCDC96_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="3 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCDC113/CCDC96 coiled-coil" evidence="9">
        <location>
            <begin position="161"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="38"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="82"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="167"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0741061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="339" mass="39520" checksum="54DE28C71018B19F" modified="2020-08-12" version="1">MEDPTCVGDDELEELEAKLEEAMRQNEQLAHENELFESYLKRNAQPNMVVEEEDKKDKMDKNKNNRQRRQRPQATISIEQKNAICSAELEEAQKEVEETKRTSERLIDTLRAVLEETDIRISELKMDAYEFKRDIVVGAENFRTGKTMAEKMIRYMEDKLRAKDAIVEKLRLKNATLKSQAQKIDAQLRQKEEMGDALHYIDFHQLQIENKQYVAKIEERNDELLKLKQTTGNTVQLLNNLKQKLNDLIDESAWLRAEIKSRTDLNEKVKAELVTVADDIVKESKAMRGLNTKEEPNADMPQILDFVSQKAHMYELQQEVANYERKVEIAELAAKKKAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XLE3</accession>
    <name>A0A6G0XLE3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_003734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000041">
        <property type="protein sequence ID" value="KAF0741173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XLE3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003181"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08267">
        <property type="entry name" value="MDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050700">
        <property type="entry name" value="YIM1/Zinc_Alcohol_DH_Fams"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695:SF648">
        <property type="entry name" value="ZINC-BINDING OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="11"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0741173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="302" mass="31283" checksum="695D06F06DEF9630" modified="2020-08-12" version="1">MMKALVYNSYGSVDVLSVHEVPTPTPGPDQVVVKVAAASVNKGDTIVSSGSPFAVRLATGCVMRPKPNTIIGSDFAGIVSAVGDNVKTFAVGDEVYGQIDFTRHGGAMAEYVCLGATDAIAIKPRNLSFAQAAAMPVAAQTAFQALRDDGKLQSGSNVLVNGGSGGVGSFAIQLAKALGAAHVTAVCSSSHADAACSHGADCVVDYEKEDFTTTQNDVDVVIDLVGNQGLRKCCKVLKGDGTYVTAGGSPETFLGRLFRLLTLRPFVSQRLVVSMLTPSQALLQTLAELAEENKVVPYPGPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XM76</accession>
    <name>A0A6G0XM76_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal lipase-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_003205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000036">
        <property type="protein sequence ID" value="KAF0741520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XM76"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000395"/>
    <dbReference type="OrthoDB" id="58570at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="2">
        <location>
            <begin position="172"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0741520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="348" mass="38586" checksum="71FED037FBAC0F99" modified="2020-08-12" version="1">MATTSVYDPTATDLATKASLPQDFDRTHLLDMLCMCREFKTPESHLSDQLNSTECASIGFDERWSVFTNTSEAKKIWLDGSEIVLGGVHALAFVSRDPEPKLVIAFRHQEGDSLGDDDMWEAMGIWGRDFSKMQDPPAISDGGFMDYITRASQWVIFGWRSAFGLNYFPKAVTLVEELTAAHTFSSVTFTGYSMGGALAQLLAIQTSSNATVFASNGIVDVLDLYTMPPTSNATLVNILDPRDSVPKMDCQMGTLLLPPTEVSAEYEDPGNVHARFVYGDLAWKQIHSTYEVIHGRPWSFENSYCIGNILDTPRSYVVDSVFQVASTQSLLTLAIGFIVFMVIRRFTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XMW6</accession>
    <name>A0A6G0XMW6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ankyrin repeat-containing domain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_003006</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000034">
        <property type="protein sequence ID" value="KAF0741814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XMW6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012482"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052050">
        <property type="entry name" value="SecEffector_AnkRepeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586:SF3">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0741814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="493" mass="55264" checksum="DF01BA85D814B828" modified="2020-08-12" version="1">MAASAFIRCNELLRFTAEFQYGDFRDILLFRKIKAPRPPPFRPQKRVSASGTTTTFVAASMSWQSPDSYEASLSLTTSCREVDFAGFAAFHEVLGPWLVVYNTSRLSLLFTALPSIVPLVLAHACMYGDVDVIQYYIANKLLDCDTIYSKHALNLAILYGQLEVVELLNTKECSREATDGAAGNGHLAMIQWIHQRRHEGFSRDAMTEAAANGHLHVVHWLHTNRSEGCHVHAMDEAAENGHIDVFLFLHTHRREGCTTRAMNAFAKQGNLAMVQFLHSERMEGCSSRAMDDAAEQGHLEVVQFLHKYRLEGCTVRAMNGAAAKGHLEIVKWLHSNRNEGCSTFAMNQAAKNGHLEVVKFLHNNRTEGCTTVAMDGAAENGHLDNVIFLHIHREEGCTQYAMDSACRNGHLSVVEWLHAHRWEGCTTKAMDMAAGQGHLKVVQWLMEHRSTQRSTTFAQDRALQNGHKDIVEYLRLKNLEVPGTTSWHGHCNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XNN2</accession>
    <name>A0A6G0XNN2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Inward rectifier potassium channel C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ae201684_003049</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000034">
        <property type="protein sequence ID" value="KAF0741858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XNN2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000949"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005242">
        <property type="term" value="F:inward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034765">
        <property type="term" value="P:regulation of monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1400">
        <property type="entry name" value="G protein-activated inward rectifier potassium channel 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041647">
        <property type="entry name" value="IRK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016449">
        <property type="entry name" value="K_chnl_inward-rec_Kir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013518">
        <property type="entry name" value="K_chnl_inward-rec_Kir_cyto"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767">
        <property type="entry name" value="INWARD RECTIFIER POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767:SF102">
        <property type="entry name" value="INWARDLY RECTIFYING POTASSIUM CHANNEL 1, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17655">
        <property type="entry name" value="IRK_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01320">
        <property type="entry name" value="KIRCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 11" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <keyword evidence="5 11" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="60"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="512"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Inward rectifier potassium channel C-terminal" evidence="14">
        <location>
            <begin position="160"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="13">
        <location>
            <begin position="458"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Inward rectifier potassium channel C-terminal" evidence="14">
        <location>
            <begin position="543"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF0741858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="698" mass="79335" checksum="E9484A3BBE2C1FD2" modified="2020-08-12" version="1">MTWQARGTAGGTWKDEWHGLAIARPSDDNARFFQKGSHESFLGRRFQLLKNPRATYKDMVYILINISWWPFTIWILGISVFITLVFAVMYHYVCTDTDDFENAFNLSYQSFSTIGFGILYPRNTCGNITLTLEAFIAMIAISVISGLVFVRFSKPRSTAVFSKQCVIQPYGRDMALVIRVANATRSHDLTDDAILEASFNLNLLRIEPKSSERHEGLVLRRYELPMLQANFLAFRKDVQLVHVIDWESPLFGLTPETCAMSDMALQVDMIGIEATTQGTLQDQALYTADQIEWGVRFVDMFMMDNDQLTMNFRLLSVTEPAIHDGYHDGRTPKQAPTKGPVLTTQFSMKDMVSQSTAHQENTEDYHGGFGKRRDHPLAVDFMTQSLLDTDEPRYSGKQSSKASSIANVEDTPLYDRIVPRYGPLPYSFQTFYSDALKMKWSHIMAVNFISFFAINVVFAILYYVDMPGVYTADEIRNNNTDFAICFYYSVHTLATVGYGSIGPKPSSTFHNFVVMVESTLGIIFITIFTGISWSKFSRPRAHIKFSDHVVVTHIDGVRVMLLRALNLRTHGDISGNSFRLGVAEKNKRTGLRQVHEVDLVNATFPSINLPATLVHVIDEASPFFRFKSDLDFLECNLQMICLYSGIDHTFSANVYARKVYSSQDFFVDEAFVDCAELTTDGVTIHYDAFHEHKPCRWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XPC6</accession>
    <name>A0A6G0XPC6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_002742</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000029">
        <property type="protein sequence ID" value="KAF0742341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XPC6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016015"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="104"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0742341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="182" mass="20836" checksum="BD9E15A302F518B8" modified="2020-08-12" version="1">MTEPRFILDQESFVRPPSPTHAHHSPTAPKEELLSPRSTFAKLQVQWSEDKTTNATTPPLTALAALNADEKDAIIVYLIQKVKDQKAMQDAAIKFGEEMAAQLVLEQHERNAAYEAKISNLEKELHKTIHEHPEVDRLSALVLDLKVQLDKERQNVQSAIKKCRRSREREKQLKMAIDPLWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XQP8</accession>
    <name>A0A6G0XQP8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VHS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_002251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000023">
        <property type="protein sequence ID" value="KAF0742854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XQP8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004302"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21383">
        <property type="entry name" value="GAT_GGA_Tom1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03561">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044836">
        <property type="entry name" value="TOL_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46646">
        <property type="entry name" value="TOM1-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46646:SF1">
        <property type="entry name" value="TOM1-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VHS" evidence="1">
        <location>
            <begin position="14"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0742854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="290" mass="31983" checksum="76E9B3D29AE39892" modified="2020-08-12" version="1">MDVSEEIRRSVNKICGGEVSNPDWISILELCDMVSSTSEHATETVRNLRRILGQPDSENTVSLALLVTESVLNNCPGFYTHIATRPFLQEIVALVDHPSPAVQERATRMLQDWATNYPEQPIFRDTYQQLKVQGIAFPNDETNAFATIPLSDEDIDVSAESYRKQPVAAPSSNIDADVKKLKQDLITVEEKIKTYRNMVALNISGEDEEDALDFLQQCQPRMNALIEAGLAGKLDEETLEACLTVNDHLISALEGKTNSSRASDQHLAGSMAHLSMTPVPAPLFTNADAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XT17</accession>
    <name>A0A6G0XT17_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_001348</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XT17"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020241"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15745">
        <property type="entry name" value="FYVE_RUFY4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="270"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="364"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="466"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="428"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="466"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="480"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="524"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="545"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0743688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="580" mass="64397" checksum="FF120ED7D3DE498B" modified="2020-08-12" version="1">MHLKTPVPLDFFQCFPLTSPEISNYRQLGRQAVHDLVTQATLTGGQYEWSLHSTYGAIKVYRAENVENPVYCARTELEATLDDIVDIFLKTTTNEVRQVNEEFFPYILDTVRLYNITLPTPDAPAHYLNVSWDLMSSPTGGFLIKKRDTCFLEQQDIIEFEGRRAWVRVLTPVTLDACPNLEHTFGIVRGEHINCGVIYVETDQPGLLQVIDFRHYHMNGLLATGGTLGNFFSSMAMEGAYRPLVFAQEKIRAMKLCHASFLSTHALVPQHTRIKCAVCLKKFGLLAKKASCQLCGEVVCRKPCSANWDLKISGVNVQVRLCTPCSATPPASSAPRRLESDLASTVVATESQVPSLWYSETTAHVSSTSSSRQHHEPPRTRRHNSVELSYERRSRSASSKESVSRHESSEPEPNPVLAGEMRGMSLEDGERRVHQAKNIDRQSPMFNSQVQTDKYAFDMKDRASRLESVDSASRTESHESSLLQQSHVQPQPMRRSSFVREDIFAEKATIPKQPVEPIQSPVAPIAPPAAPPAAPPATPQAAAPPVAPPATPPAAAPQKPQKPPKKDPPFGSFLVPHVIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XTJ5</accession>
    <name>A0A6G0XTJ5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7646 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_001576</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002984"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042791">
        <property type="term" value="P:5S class rRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056063">
        <property type="entry name" value="DUF7646"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044210">
        <property type="entry name" value="Tfc3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24657">
        <property type="entry name" value="DUF7646"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7646" evidence="2">
        <location>
            <begin position="309"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1125"/>
            <end position="1147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0743934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1420" mass="162910" checksum="4B70E5F850C0C15C" modified="2020-08-12" version="1">MAGVNRILARLIENVALEGRSGISVYELFERYSGTPDSFLREACWTALVKASATADEIPALHFSIPSRACDVDEIAKLTLKDASHRQVYVVACQALRYRALHLTNHITIAEDSTSFLILETVGKSRAKGLSTMDINTQIRENIPRNADHKKFDAELRTLHHYMDRLISQKLLVKKMLQITENFKCKRFNMVLLPRFDSEFDHEKSVPGSIFEEDSSWKYRAVDHLLSYLSQQENRQCTFNDGMRGICAEKKKLEALKNHIICESKKAGSTFPIEIFTAQRSDARQKFWCLRLRDIEENSGDAEEKEPTALVHEMGLLEQIFNMIVAAGDTGVTSPDLKNNLGLHGKTAYRIFNIITTEYPVRMEKTVIGRNSVYRLFSMISNRSMVPQASNPSKGSHKYTLRKSLVDTVSKSTEASPTDTTAIRRQHILDRLRAEKVVSLYSLRSSIIELENYAHDGQRCHFNSGHRVDVRSIIRIVELHPEMKLQYCEMPLKSSLLASSTKTSRLILHVSATQDDLKTYLNQYSRDSRLQALNSKAFVNPNVMIHPNLEPSTTSIAYKFKNTLTVKSLYERDRERQSHLLGKCHGFLYRCRLFHIHLFEYLQTATVTKLLSDAAESLAPDRLFTLDPVFRSMPVVLYVRILGIGQLLLPDEVTHVQNAIKNKTLLADLPKEMQKKITHRQNRRLTRLLRTLIDLRVIRPYRLSHDELMTLLEFTDDAGDLDVPRLVQYTLYDRLVGGFFVWHHAQRLHFEDPEWNTWNSVHVNTTRCVYSFGHEVPLAHTFSSREAVELFWEAMECCAVEQLAYSPAPGQVVKVPPLDVAEHITMSTAKNWTPNTHGVRFNRRDKKTHEPRIPGTNKIIMRKRMKPKPCRPLRSKKYLFVPRGVRVDAPFTPEEDHAILQVYFDQLQSIWKVPVPVEMQLPDEPVAIRNADVFRTHVSMVSITRAATSHRSVNRVRRRIEELLGMAPLKLQHHELKKTFFGSTRFTEEDEVASNPRLSALVTRVFMILFTSDGAYNQMAAEHLVGAWSRQEITLVWRYFWLKGWIVAPKPYHIRGFVLTRRFQEIFKGSSTVSYPLAMFIEAAEQASFLESRDVDDDEDDNTIRCCSAIEHAALVLGQGSYEVQHTPLPEKPKSKPQSMKRRRDHRHATSGVGLLNHLDQSELDQWQAVFHLTTQETRATECAFSHQMFPEPPLKRTKTTKLIPFAHIEQVLLAAEERGLSIPELVNALNGRRAIVEESIETYQEEGKILQVDGWTCCRYVLPQFGHIWTVYPYATTSNGSIELDTTMGTTPHPWLKLTTQPNGPWLVRFQRKLVALLITYPGCGEDAAYTAFEGVLPLQQLRIVLSDLVQEEVIYARIVERQPASFHLFGNNESVPRIYVPGDTSLLQIDRSRYVVHYFPTPDCIVKYGFMVKDINRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XU05</accession>
    <name>A0A6G0XU05_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_001504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XU05"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005348"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="376"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0743859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="434" mass="48188" checksum="56B53B33E2107773" modified="2020-08-12" version="1">MHRSTSKKDPRGFNRSLLVGRGGRFNNLTKNNAIKVAAPRPINTPSLKMESRAQEVNATPVNTSRMCWSKPPSAATGTPATNRQAATPAHEPAPVVETTPAESPSQLPLLKHDGDGKESHAASAAENSMSKTQATPNRRNMNEEMQDYTDPFLSKTGKWGDDAIEDDLQRTQNAQHLAVEMTTSQKSHEPYDSFSSSLWSASSWSSRTAYSRRELDRDQRPNSHVVSCQNYMWTKDHSSSNDTLASPWNTSPLPAPIQPIRILKRDQDRKSATQEPQEKSTPTLPAQGIPIDPTEPAGNEAKQTKTTEISCDEKEKTKGHETQSRTLLEKNHIEKSKKGVPSRNHRAPSNNTSAHTRKEKTSKNRVTMVYRPKKQSPATTTEETPFTPSPVQKGENPQQTQQAADILAKDNSHLRLQTSVVTPFEEKRRHIASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XU61</accession>
    <name>A0A6G0XU61_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_001584</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XU61"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012260"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="74"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0743943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="377" mass="41887" checksum="42B36E759AB7755F" modified="2020-08-12" version="1">MGQVVSWCFGETDPAPSMLLADEKAKAARGRGSSTSQTAGSEQIETRPEIYRSRPKAIMSSGPMYAAGSFESKYVLGSVIGTGSTSVCHLCESKATGEQFACKIIDKRAIQSKSDDLLEQFQVEIQVLQSLDHPNIIHMEDVYQTDSRICMVTELMEGGELFDYVVHKGTLSEVEASCLVRKITSAIAYMHACGVVHRDLKPENLLLTSKSPNAEVKIIDFGLAKLLHDSQTRSFLGTRGYLAPEMLRRQSYSKSIDVWALGVIVYVLLCGCLPFNDDGSKINSDKAARAKFGLRFPRWASGLSESAKDLLRHLLEVDSEKRYTAEQACLHPWVTGQRTPNKFLESPNYLKTIKQRQAEKSASRIDDKVIQSRRLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XUU4</accession>
    <name>A0A6G0XUU4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Condensin complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_000920</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the CND2 (condensin subunit 2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XUU4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021060"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022816">
        <property type="entry name" value="Condensin_barren_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13108">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13108:SF9">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05786">
        <property type="entry name" value="Cnd2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017126">
        <property type="entry name" value="Condensin_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="8 11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="428"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="574"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="106"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="149"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="494"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR017126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0744441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="834" mass="94195" checksum="81215898EDED1BD7" modified="2020-08-12" version="1">MGDGDAGDERLKRSHESMSPQTPVEIRKKMRKNAKALREDSGSEDDAHLQRLAKKKKVEQHPGKATAESKPAAPDDSELDDDDIVPPIPLNVTNRRVSDKFHTPPKASTSRSVFETTTNAEENRRNSGLEANLPPPAARVLTEEEMERRRRRRNSKTFQSRRKSLTPNAKAKQYVSEMYSTIIKMSSENKINSKNSWSLHLIDHMEDILVDKQQDDEAPDSDTYNFQKASCTLDASVKIYSYRVDDTWNSSFKVLENLTRGDEVRHDDGDEEATEKRTTSKKLTVANTIETNLKNINMKSVDLEFQVDPLFQKMSQAFDEGGAKGMLMVNLSVHNGCKIVLDSSNVKASNQTDTATFEEEKPRKMINIAGLTKRLRSSTTAVESFDICPRLDHFYDQLKTMNNEYFDKKISVPRLDVTASSHNRRLTLLSQGLITPRKTPSKTPVKSEAGDTLGPSQSAEIEQPDFDMGGGDDGMDYDGDAPQTPAPKDEEETKDPLKEEVKPEPQEPSIAKPLKFEDEEEEQNTHLLESALLRSVNAEQMDEYSFFDAKSLKNWAGPQHWKVKLPGIRIKRAVRKEAAPKPAQEEENTTAPKKKRNTAGIKFNLTAAEVTQALKKPRHKKSLEISATVLKKNESMAAELVHPVDLHMKIERFYQLFTRPRSNVMFASMMRPRKDNFELSIPTAPISRNNDDQDDGIDFDGGGNDFLNDEDFQVSGLIQAERIVDKVDIQYEKFAKRVDVKKLKESIWETLPFHNAEPDPVDELAQATEKMGIKEEVSFEELVSEVAPKVPSNVTVSFYFICMLHLANDKGLELIGQDDMRDFKILHDPPAPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XV34</accession>
    <name>A0A6G0XV34_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein prenyltransferase alpha subunit repeat-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_001007</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XV34"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009253"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008318">
        <property type="term" value="F:protein prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF3">
        <property type="entry name" value="PROTEIN PRENYLTRANSFERASE ALPHA SUBUNIT REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0744533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="41869" checksum="8AA43F6035C1B50C" modified="2020-08-12" version="1">MGDRNYVDELTWLFDEDPEIDEIGMVYLEEENEAFVLAEHKLGISMTMIPVIHRQSKQAFFEARERQDVKTILNATRAMLLVCADFYTAWNARNTLITEGHLSHENEIKFMNIVLSLHAKSIDTWAHRRWVIQRFCSHLEGDTLEGFLAQELALCSKLCEQYLRNYFAWSYRYCIASKLSLPSLHAELSASQTWCEQHLSDHSGWNYRHLLLSSLLNRVEDPLRLLEQERNFHSRLVELYPDREALWCYRRGILRAVAQHLSTSSAKETWPEDLSSNLSFHRALPLGVYIQHEVQFAASFQSDYALRYRAFALELIIKHDSQSAPPEVIQKHQEVCRELKSADSIRSSFWDGRNDSVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XVE4</accession>
    <name>A0A6G0XVE4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycine cleavage system P protein</fullName>
            <ecNumber evidence="7">1.4.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_000908</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 7">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GcvP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="7"/>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XVE4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021048"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016594">
        <property type="term" value="F:glycine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00613">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000005">
        <property type="entry name" value="Glycine dehydrogenase (decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000007">
        <property type="entry name" value="glycine dehydrogenase (Decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00711">
        <property type="entry name" value="GcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003437">
        <property type="entry name" value="GcvP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049316">
        <property type="entry name" value="GDC-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049315">
        <property type="entry name" value="GDC-P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00461">
        <property type="entry name" value="gcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001696">
        <property type="entry name" value="PRK00451.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773:SF1">
        <property type="entry name" value="GLYCINE DEHYDROGENASE (DECARBOXYLATING), MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="GLYCINE DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21478">
        <property type="entry name" value="GcvP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Glycine cleavage system P-protein N-terminal" evidence="8">
        <location>
            <begin position="34"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine cleavage system P-protein N-terminal" evidence="8">
        <location>
            <begin position="487"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine dehydrogenase C-terminal" evidence="9">
        <location>
            <begin position="813"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR603437-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0744428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="996" mass="108383" checksum="83A965BB7DBBF00F" modified="2020-08-12" version="1">MFRSIKHVRAVIGKSHTSRVFSTDPYRLTDQFARRHIGAGKEETAIMLKKVGVNSIEELISKTVPSEIRLTEKLNLPEPMSESQAYAALKKIARQNKTYKSFIGTGFYDCLTPFVIKRNVLENPGWYTAYTPYQAEVSQGRLEMLLNFQTMVSDLTGFPIAGASLLDEATAAAEAMALCNGAFNGKRTKFFVANDVHPQNLAVLRTRAEGFDIEIVVGNPLTDLDFSSNEYSGALIQYPNTFGSVEDYTKLTEAAKASQSLVVVATDLLALTHLKTPAEFGADIAVGSAQRFGVPLMFGGPHAGFIATSEKYHRKLPGRIIGVSKDSRGERALRMAMQTREQHIRRDKATSNICTAQALLANMAASYAIYHGPEGLKKIANRINLLTSTLVAGLGEHTKTKLVNNHFFDTIEVDLSGSGLTGDEVQRRASSKEINVRVINSTRVSISFGESAELSDLGKLLYALGANDVVSEAQLSSLKTAASSVQSSSIPASLKRTSPFLEHKVFNSKHSETELLRYLKTLEDKDLALNTSMISLGSCTMKLNSVSELEPVSWPEFQNVHPFAPEDQTKGYLEMIETLHQALAEITGFAAVSSQPNSGAQGEYAGLLAIRAYQKANDQGHRNVCLIPVSAHGTNPASAVMAGMKVVVVKSDDAGNIDRVDLEEKAKKHANELSALMITYPSTFGVFEEGVKDMCELIHKHGGQVYMDGANMNAQVGLCNPGGIGADVCHLNLHKTFCIPHGGGGPGVGSIGVASHLAPFLPGNPIVLTGGEGKHVVKKNDLSVSAGPFGSAGILPISWMYIHMLGEAGLVKATSHAILHANYMAKTLEDHYDIVFRGKNGTCAHEFIIDIRPFKAHGIVEEDVAKRLQDFGFHSPTMSWPVPGTLMIEPTESENLSEMNRFCQSMILIRQEIEDIIQGNIAVEDSPLKHAPHTVDVVTGDTWDRKYSRQQAAFPAPWHNGGKTKAFWPTVGRVDNVYGDRHLVCSCPPLDSYIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XVJ5</accession>
    <name>A0A6G0XVJ5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_001150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XVJ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007139"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF61">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0744693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="197" mass="22232" checksum="BB01F616163B0FBF" modified="2020-08-12" version="1">MLIDARLNAKGKQQVSALRRPSTERIELAQVQALHQRVLEKKLHESIQVVITSPLTRAIETALGGFEGTGIPIQVNPLCREMLDASCDVGRQPAELAREFEARGVDMSKLSEYWWLNTPTDETKIIPHTPKELKALKETMNDMEARVRRFLAEIEALPESTLAVVCHGDFISWLTSTYPANCAIVKTTLRQLWAQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XVL9</accession>
    <name>A0A6G0XVL9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Anaphase-promoting complex subunit 4 WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_001071</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the IFT172 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009481"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000020">
        <property type="entry name" value="Intraflagellar transport protein 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000012">
        <property type="entry name" value="intraflagellar transport protein 172 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000013">
        <property type="entry name" value="intraflagellar transport protein 172 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056168">
        <property type="entry name" value="TPR_IF140/IFT172/WDR19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056157">
        <property type="entry name" value="TPR_IFT80_172_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15722">
        <property type="entry name" value="IFT140/172-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15722:SF2">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 172 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24762">
        <property type="entry name" value="TPR_IF140-IFT172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23387">
        <property type="entry name" value="TPR_IFT80_172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="IFT80/172/WDR35 TPR" evidence="10">
        <location>
            <begin position="627"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="domain" description="IF140/IFT172/WDR19 TPR" evidence="11">
        <location>
            <begin position="976"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1399"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1404"/>
            <end position="1437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0744604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1766" mass="199638" checksum="14F14FED0D614292" modified="2020-08-12" version="1">MQLRHLSTVLPPTEGMCKVTAIAWSPNNRRLAVVTVERVVHMFDAATGERKDKFSTKPAEKGDKNYLVKALAFSPDSSKLAVAQSDNIVFIYKLGLEWGDKKSICNKFLQTSSVTSMVWPTSHPNEIVFGLADGKVKIGQLRSNKPATLYATGSYVSTLCTNVDGTAILSSHYDQSIYRFIFDDVNGGSTQTKIAIHSCVPYALSWGEAIVAAGNDRKVTFYDKDGGVVRTFDYSSDDKCGEFTTSVFNPTGDSCVVGNFNSFYVFNHHVKSDSWEAVGVKTIENLYSVTSLGWKFDGSRVAVGSVCGALDLYDACVRRYRYKGKFEFTYVSLSQVIVKRLATGARVILRSTFGCEITKVNVFQDRFVIANTSNTLLVGDFDTAKLSEVQWQSTGSEKYMFENPAVCIIYQAGELTLIEYGQNEILGSVRTEHLNLHLLSVRINERPIESVQPADDNKKMAFLLDLQTISVKDLHNHTSTTINHDSRVDWLELNAHGNLLLFRDKRRQLHLFDMDTQTRSTLLNYCNYVQWVPDSDVVVAQNRTSLYVWYNIRSPDKATIYQIKGDVEQIERANNRTEVIVDEGMNTASYQLDESLINFGTAIDDKQLVRAMSILEPLELTPETEAMWMQLSAEALKCNDHRIAERCVAALGDVCRCRYLRKVNKIDWMEKGRLGEGMVHWKVRSKLAQLKNDYRSAEHILLSQGQVDEAIEMYQLLHKWDDAIRIAESKNHSAVDSMKRQYAEYLLSSRQEEKAAALKVKEGNYASAVNLYLKGGLPAKAAALLNERNLGRDHRALLESVADALYSAGMFEKAGDQFEKMEQEDRALAAFIKANAFRKAVELSRRVFPDRVMKLEEIWGDYLVSQKQMDMAINHYIEGNVPTKAVEAALNSRQWAKAGQMVETLDDEIALPYYRRLARHYQDAQQYEQAERCFIKADAARDAVEMYTRANKWDAAYQVALNHMDKYETERLYVEQAHRMERQGKLKEAEKLFLTVNEPDLAINMYKNHKNYEQMIRLVTKYRKDLLKDTHLYLAQQLEHEGNFKEAEHHFAEAGEWQAAVNMYRTNDMWDEAIRVAKYHGGINASKRVAYAWAMSLGGEAGSKLLTRLGLIEPAIDYAIESGAFEHAFELARNCAPKKVPEVHLKHALFLEDEERFKEAEEEFVKASKPREAVDMYIHQQDWQNAMRVAETNDPASVSDVFIAQARLWVERKELTRAEGFFLNAGKPELALTAYIEAAMWSDAMRLAKRHLPHKLSEVNMAHQRAIFSSGHKTKEELLEACEIWVSCQQYVQAIDAYLSITNEQLDSPTGLEEIWGLAVELASKHDRGRYKSVVEEVASRLLSMSMFDAAADYFKSIDKMSEALDCYLRTNNWVAAQKMCEQHAPELLPRLERAQQASAFGDKSSKAEEKSSPASEAKESKEAKNSDAKGSSEAKDAPSNALEVWMQRGEWDKVLTSAAKHGPKSLAKYLVLRCMRLVEHDEADGAIATLLQYGIPLVDNTLETVELVVRKSLGCKVTIESTPEHAAAVGNLVKCLRKLIKELKAAKEVDMVGKMEQYLLIAHYCSFKYAAQAAGLTDIACKISMSLLRFVGTLPADKMFYLAGAACREKKWLSPAFVFFNRYLDLTEAIDDGTTNNLDNSDFLGTDIPSPRDFDVPEEQYLPEESAREEIRDWVLTISMDQQVQEKLPEKPCPNCQASIYEGTLQCPECKTKFEACIITGFPVGAKTTVHCTNCKVIAERESWNKWIKQFGSCGWCAAPQKMSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XX28</accession>
    <name>A0A6G0XX28_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_000624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000003">
        <property type="protein sequence ID" value="KAF0745047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XX28"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001747"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0745047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="603" mass="68723" checksum="2D82D46BEF5FDFF4" modified="2020-08-12" version="1">MDDDDCYGFGSYEEIFSRPTRTSPNRAASAFLLSPSKANARSASCDVEVGTHLMDNGFFLLETDITFSKNNALFHGRHIGLKIKRSGKLLNFNFPRQSPIKGSSMTAKTMCVDSNSRTHALGDLYMDNKELFWHPMRHSDTSQTSTGQVYGSDRYSLRIDRKAIKDIAPTKVQNVVLALSITLATIDVCFEFSFMPGPYHKSSNRDELLSLLMDTPLTDNAPTPDEIAAVFDGAHPAQRNTDEKKQVVKSPRRTQRHPGWKNERDKAIRSYLSMDPQSLKAMKLAKQIEDEFNYPIGPTSTTKQSFLDDKDYRQEQVSTLSRVMDDMKAAWKRNDEAIDRLLSVSCSKNDEDDLVYHDTTTKREISPKEYELRYTKHIIETPIILIGDHGSASRIEFSRTSAIIDSAFIPVRRFELPSVPLSLSGQAKTEAEHEREMFMEEIHASKQNLWQEFAKLTQMHFEKIQSIRVNYARRMEERVLAAKNDQSAKPSREKTSRRRSMVPVQLDDLKENRGNTDKKRKNGSGDDEKQKRQSRRQSVLLQPLEESKSDDESNLCNLCFVSPLLQPCLHSVCDKCWSKLSQGKTDSAECPWDRQAVVPKRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XXM9</accession>
    <name>A0A6G0XXM9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_000497</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XXM9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002341"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000018">
        <property type="entry name" value="S-adenosylmethionine mitochondrial carrier protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="73"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="164"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0745483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="27582" checksum="44D1F76C0B6E8B6C" modified="2020-08-12" version="1">MAGTGVDVALYPLDTIKTRLQSSQGFIKAGGFKGVYKGLSAAAAGSAPGAALFFSTYESTKSFLQKQNPHLADSPAIHMASAAMGETAGCLIRVPTEIVKQNLQTGAYKTFQESVSSIYANKGIAGFYRGYWSLLAREIPFSFIQFPLWEGLKASWGKYQGEPVSPVQGAICGSISGGIAAFITTPLDVVKTRLMLGKDAQGVEYKGMRDAFTRVYTQEGWQTLFSGVKPRTMWITIGGFVFFGVYEQASASLSTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XXZ1</accession>
    <name>A0A6G0XXZ1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_000074</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the hook family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000001">
        <property type="protein sequence ID" value="KAF0745621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XXZ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011476"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030705">
        <property type="term" value="P:cytoskeleton-dependent intracellular transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22211">
        <property type="entry name" value="HkD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008636">
        <property type="entry name" value="Hook_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043936">
        <property type="entry name" value="HOOK_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947:SF28">
        <property type="entry name" value="GIRDIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947">
        <property type="entry name" value="HOOK PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05622">
        <property type="entry name" value="HOOK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19047">
        <property type="entry name" value="HOOK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116907">
        <property type="entry name" value="Hook domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="9">
        <location>
            <begin position="10"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="680"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="221"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="331"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="550"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="483"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="684"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0745621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="710" mass="79821" checksum="FD86788C099A6DD2" modified="2020-08-12" version="1">MDGGAFHLDSVKRQSLLEWLQTFVVDEPVATGFPSTISWQVLADGVFLARVLHQMDPDYLSMDAIKEEAGGSMNWILKLANFNAIARSVESFYHEELSVRCEVANHVDLNRIARAETVDTDVEIELSKVALMLLHCAVNCAERQTFVVRIMNLEQHVQQSVMAMIEQISVAFPPLSPLHGSSALSPSLGNLDSTPVRGFSGEQSEEVKDLRSRLGAMEKKWQDAEHDKREITKEYEALSAEVQASRKKINILEEENNRLTSERQQAVARDNKKLEELVNAEKHSLTIELQAKTEELLQVKKESSERLIMLEHEVRRQADELDISRSKLVALAKLESTVTKYKQKLDEMNTVKQHIKEVEAQNAAYLEKMLDLESTVKTMASLKSSIEKYKNQVVELETANVEAMSTLQIKEQKCRQLQDDLESALHGKEFLEHQLEEMRSHIPQEGGEVNYTSAADLLGGGLDLREQIARLQRENRQLKEQVASSTASSNSTATPSVDILALQNERDDALRAKDAWQAKALDFKRQYDLLAESTKGAAATGGSGVSSAQLAQLEATNARLATQLQAHEEQARKMAANTEESDSFRATISELTNRLKEKETVINNLSQDKEKLETYTKKTLHAVQSKYMVAVSTHRNQLAEKQAKVDMLETKLKELKTSQKREQELLMSSFYEIGGEMQRRTMMPQAPTSASSAPLAAWLPSKRSDRSSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XYI7</accession>
    <name>A0A6G0XYI7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_000102</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TCP11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000001">
        <property type="protein sequence ID" value="KAF0745650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XYI7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011448"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008862">
        <property type="entry name" value="Tcp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832:SF11">
        <property type="entry name" value="LD23868P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832">
        <property type="entry name" value="TESTIS-SPECIFIC PROTEIN PBS13 T-COMPLEX 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05794">
        <property type="entry name" value="Tcp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="392"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="10"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0745650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="852" mass="96319" checksum="E3976137FB49C94B" modified="2020-08-12" version="1">MARIREYPMKSSCQARLEARKAQVESLNEEMNSAEQLRALRERLCRAREKRTSQVSCRRSMARERVARAQAIARATKLEEISRSQGYLTRLQTRMEEAEKRRSKNLEQTAYQCQQQNERVTTALQVLVDRTIEKRRAYDASLRAARHRRATLTSAYVSKLAQRASLVELTKGRIQSTRALAAKTLQRWIRKCNAVRRARLVFGPLRISAQSVIDLWIKVGQTSFEASMELMQDRKLSARAHTLSKVLCPGLSHRILLMAGMLAHHPRDTMNQGWDAVLHFTAVQVNRALVDLVASWPSNQAFASAWSRWEARCTAYLATFAHWKHQDGERLTADMLNVYAELFTVHKRAELEGEQDIMAKTALQLQQLRKAVTQTLGAAAAKDRLESVEAELSQRLALSSPPKSPPSPPTGNSNPKPDLEMTKSVFANDVLAHELILNPRFQLVRGSDDDLRDPQEKLKRRIEAAFWDHMRKARDREWMVRTFSELFDLMQSALKRPTQRWPCQMTVEQISAMAHSASWNEWQPVLTLLLEAIAANEAPARNDTTHQLLAEVNSMAPPTSEAEWFDRLTSFLHFAYDKMDEMRVDGINAHLAMLAPYLVRHGVEHEAKKFTEKIERGEVVLDNTAAWLRREVSKATENDQQAWAALGLAAAVRTILRRGLVSVLQEVGGDMPWPETFAMDMQRMRDWRNRLDSIALQASFLALIREVCGSHGVGYGGAVAADFCSKMAVLLRDDGVKMDDLVAQVTHEVTTQLGNRSWSNESRDALAHRVAHVAEPSNAIFGLCSQRAFMAVRSVLVDGSPNVPPALQLFATELEAISSEMMQLAKHNEAVHASFYNRLVRDALQSHNSSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XYY1</accession>
    <name>A0A6G0XYY1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase</fullName>
            <ecNumber evidence="5">2.7.8.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">GlcNAc-1-P transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">N-acetylglucosamine-1-phosphate transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">Ae201684_000153</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis, transfering GlcNAc-1-P from cytosolic UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol embedded in the cytoplasmic leaflet of the endoplasmic reticulum membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-alpha-D-glucosaminyl-diphospho-di-trans,poly-cis-dolichol + UMP</text>
            <dbReference type="Rhea" id="RHEA:13289"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19507"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58427"/>
            <dbReference type="EC" id="2.7.8.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:13290"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.15" evidence="5"/>
    <dbReference type="EMBL" id="VJMJ01000001">
        <property type="protein sequence ID" value="KAF0745703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XYY1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011181"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003975">
        <property type="term" value="F:UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06855">
        <property type="entry name" value="GT_GPT_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033895">
        <property type="entry name" value="GPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571:SF0">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00045078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF0745703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="375" mass="41236" checksum="BB1D083DA9B60694" modified="2020-08-12" version="1">MWSILGGASVAGYVAVVFLIGIVKNHLPPKLTGKDLCKKGTPAGDIPIPEALGIVSGSVFVLVLLVLSYYVEFHQASMRWGIVSIAAMITLGFTDDLFDLKWRHKILFPPLAIIPVLLHYSGVTAVVMPTPVRGLIGDGGVLHPLLSTVFQVSPDGGIVDLGYVYYLYMGMMAVFCTNAINIYAGCNGLEAGQSFVIGLAVVTLNLTQIIRGLDFQHYHLFALVIMIPFLMTTLGLLHHNWYPSRVFVGDTFCYYAGMTIAVAGILGHFSKTLLLFFTPQILNFLYSIPQLFKFVPCPRHRLPKFNPKTGNLEPSTISPDSTRSNMTILNLFLVIFGPMPEKRLVQLLLVFQVVCCVLAFGVRYGLSSLFYDAVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W2Y0</accession>
    <name>A0A6G0W2Y0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">eRF1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_019191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000469">
        <property type="protein sequence ID" value="KAF0721269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W2Y0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016646"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004403">
        <property type="entry name" value="Peptide_chain-rel_eRF1/aRF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10113">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1" evidence="1">
        <location>
            <begin position="7"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0721269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="78" mass="8935" checksum="BE2BFDE59D35221F" modified="2020-08-12" version="1" fragment="single">ETGETLEVVEKEPLVEWFANNYKQFGTTLEFVTARSQEGSQFCQGFGGIGGILRWQVDFMEMEYEGESDGDFDDDDFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W4S1</accession>
    <name>A0A6G0W4S1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_018638</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000345">
        <property type="protein sequence ID" value="KAF0722158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W4S1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015691"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050606">
        <property type="entry name" value="Calponin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003096">
        <property type="entry name" value="SM22_calponin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385">
        <property type="entry name" value="CALPONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385:SF14">
        <property type="entry name" value="TRANSGELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00888">
        <property type="entry name" value="SM22CALPONIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="2">
        <location>
            <begin position="12"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="2">
        <location>
            <begin position="272"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="409"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="474"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="510"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0722158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="590" mass="62693" checksum="FE8EC4DACC964986" modified="2020-08-12" version="1">MAKARTSGGYDKQSEDEAREWIEAITKRSIGDDFGQGLKNGVILCELANALDGSLKLKPSTSNMPFKQMENVSAFLRACRSLGVAEFDLFETVDLFELKDIGIVVRCLHALGRAMQKKPGYSGPTLGVKEATKNARQFTEAQIAEARAATSLLNMGSIGTMQRTSIDSSTSVTFGADAAKTPAATPVVASETASDVPSIFRRGSSNSNLSTPAPTPTPAPEPVKTSGNVSIPPAFQRKNSNSPPKPAPVQTRGGGFGLDAELAAKAIAKYDYALEASCQAWIEAVTHSSFENGFGETLRDGQVLCLLINTLQASSQVPVNPIKIESSTNNFKLMQNIKHFLAACRSLGVADVDCFETVDLFELKDLGLVVRCIHALSRTIGKKFPKYTGPLVDRLEGSPEPVQKVVAPAPTPAAAVQPPAKVDTTPEAVESEVDSTPVPSVVKKTWPPAKEVDSTSQDEIKPPAVQSSFVQKSEPVVPAAATPPKAVEEPAPKQTKPAWPPVRTTDTEASTSSSRPQLPSSLFENTVEDVKPSEEPTPTVAPPAKNPPVHRAPAPMARVNWPGARKETDGTVPSAAFRAGGALPTRTNWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W4U6</accession>
    <name>A0A6G0W4U6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carboxypeptidase</fullName>
            <ecNumber evidence="2">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_018758</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="2"/>
    <dbReference type="EMBL" id="VJMJ01000352">
        <property type="protein sequence ID" value="KAF0722008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W4U6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005904"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF201">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="497"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="505"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0722008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="516" mass="57435" checksum="F73EE3599D8E842B" modified="2020-08-12" version="1">MAQDDSHKIKSLPGYNDPKPINFDQYAGHIQLPSNGQKMFYWLVEAETNPSTAPLVLWLNGGPGCSSVNGFFTELGPFVVESDLSVKRNPYAWNRKANMVFLESPAGVGFSQPRLNESDYNDDFTADRTYEFLEQLFARYPQYKDRDFYLTGESYAGVYIPYLAYKLVKQPIAHVKFTGFAIGNPFTDSKVDGGAKLDYLYSHGLISIESYQAVGAACPPETLWQCTRAGPNCTEGCRSVVDTVTTSANLNSINIYYIYGDICVLKDGQAGKLTNYDIRPNTHRGVYGPCNDQFAAAYLQQESVQEAIHVSGGHVDWTDCASLNYHRTPSSLQKYPTILSAGLKALIYSGDADAQVNFIGTQRWITKEALNLPVKDKWKAWFGPDKQLAGYTESYTNLTFTTIKGAGHMVPATRPLHAMYMFECFIFGQAACASFSYPKDSLEYLSGADLTAPTGSTTRTDDAAATQIDYLWWALGGVILVVVVFFGWRFYASKQSDKDKREYTELSNETKPLTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W5A9</accession>
    <name>A0A6G0W5A9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_019214</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000500">
        <property type="protein sequence ID" value="KAF0721166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W5A9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006304"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0721166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="260" mass="29703" checksum="90A8CFA7F6B57CEB" modified="2020-08-12" version="1">MSPSTSSNSVVPAGCPILDEINSSTFPQWNKQFMQYAKSAAFDSFYLESNYVPEDLTSRFIDEYDRTLRGDKVTHEAEYYVDPSLSGNERTARLAEVYAYETRYRKATYDRLSKTTLANLRSDATIFLNSALSPLLRSCFSNESDPYLLYQAIRARFENHATRTDPSSILRADLRVSWTPGEACDNALDLLKEHQANYRNSMQPLDWQNLSVDAYAAHFWDLRYLVRASEVFQREDCLGSAAQAPAICAQEWLSSVQHYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W6G8</accession>
    <name>A0A6G0W6G8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_018262</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000327">
        <property type="protein sequence ID" value="KAF0722663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W6G8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018204"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013111">
        <property type="entry name" value="EGF_extracell"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07974">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026026572" description="EGF-like domain-containing protein" evidence="5">
        <location>
            <begin position="18"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="151"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="237"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0722663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="323" mass="32801" checksum="042511CD58DDAAC9" modified="2020-08-12" version="1">MRIAVVAAAFLTIQVSSELLRQFNGWAVQFGTENASTSPANDVLGDSCSSTKDCPTGTSCVAGSAVVAIQSCVQFPVCGGNVPGNCPGFLRSGQLVCAWAPVAGSNCSDGTASCKSFPNVTSTGIYKCMSLDRCDAIPGGASCSLGCKASNGLTCNGRGSCQTLNGTGYGCECNSGWTGVHCETVVNGTCQEGVGSCGAHGKCVAGSCQCDLDYTGVQCEKPATVVPVTAITPTVVPSASATTSPTSSDPNKDGSGSSDKTTEHTTTVVLIVVLVALAAIGGVVYLILAKKKREREAAELAALMQREDDEDRVPTPKSAIQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W6L2</accession>
    <name>A0A6G0W6L2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_018941</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000367">
        <property type="protein sequence ID" value="KAF0721763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W6L2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020499"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0721763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="114" mass="13411" checksum="31BD259DCF6D35DA" modified="2020-08-12" version="1">MQDEVPIIKTRRRYSLETKRNVLRALSDHTQQRVADLSGIPLRTVQNFVREKEKIWASLHAKRRLHIGEPGRPEILPGGDDLLDYMVAMREKHFPLTTYHVVQQVKANNQEWIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W716</accession>
    <name>A0A6G0W716_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_018122</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000320">
        <property type="protein sequence ID" value="KAF0722891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W716"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018999"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0722891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="655" mass="75697" checksum="5BD8F851B2208F2F" modified="2020-08-12" version="1">MLQSWLSRLQCLHGSIPKKSVSVKRKASLQDSFMVLRAELTATSLNSSLQARCQAIWTKSFDLFTALPVFDDVALVQDAEVSVRIEGAVVHFKGRHRAVDTSMSISTASTLTACVAPVAPSVVSVEEQEVSVANQPIRRHFVHDSHLFTRAYLLGRGFRVILSVSQSSNVQSMSPSLLIQAYCPRNSKTSNFDINIDHLVAMIPQIRSRIYLPSELPSSFKHALTHWTSWFTPIVPCLEWTQEEVLALRYPSVYRACHVMQFKGVQFFRGLLSMHAWMDFSVQVKFFYVSSLEILETRISVAHLELLLPNYLAHVLERYRWPDLFGTIQRQLWLEYTTRGFELIVAGQTPRGRPIEHPAIKLATSEWAVFLRDEHEKLAATYGDCIRLTASVALRKKFNRQVIQAATTIQRVFRGHMGRMAYHQAVYEHAWRLNELGAMPGTRRGRNNRLGWFQDPHTLVAYGFNPQHPAITVACDHWILNWFDMERIVLVHADELIRSNVAAQCIQSYIRRWLRQRFWHLVYRSVVKLQYEFRRALRRQLRRHERDKHGISFKFARRIRHSWLLLHVFFQKTNDDDGKDVWRIKVAGIHPRTNVATEQIVTKEMLAHHGILSQGETMAHRDIATRLVDSIDLFYSAQSNLMAFRIIPNSGKELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W717</accession>
    <name>A0A6G0W717_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Spindle assembly abnormal protein 6 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_018325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000330">
        <property type="protein sequence ID" value="KAF0722592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W717"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002178"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10142">
        <property type="entry name" value="HD_SAS6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.210.20">
        <property type="entry name" value="Spindle assembly abnormal protein 6, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032396">
        <property type="entry name" value="SAS-6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038558">
        <property type="entry name" value="SAS-6_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34230">
        <property type="entry name" value="ASSEMBLY ABNORMAL PROTEIN 6, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34230:SF2">
        <property type="entry name" value="SPINDLE ASSEMBLY ABNORMAL PROTEIN 6 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16531">
        <property type="entry name" value="SAS-6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spindle assembly abnormal protein 6 N-terminal" evidence="2">
        <location>
            <begin position="61"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0722592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="266" mass="30382" checksum="CF51E89E28AD8B8E" modified="2020-08-12" version="1">MDVYFSPSQCSVVVDIMTSRKFADGDFAGPSTFESIHHGSSTSDLSLVDDIDPSIAGGYRVVYDRETPFELRIQDSDNAPQQVGTLEAIKVKILLLGDDNDLRALKIELSTESDLFFYYVHVCDLEGFHLVQEQQKLMVDFADYANVLIRMLNNCIKEPHNHIAVYLMQADGRARLDFIQNMEYKFVELLSVDFSRLPEEIVRQHITYRYNTIKNRVTALQSRLHEVNNLVKVKNPSLLLQLQKGPPPPAVNPREVLATRSHSRFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W7M2</accession>
    <name>A0A6G0W7M2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_017883</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000314">
        <property type="protein sequence ID" value="KAF0723136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W7M2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012868"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="15"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0723136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="361" mass="40684" checksum="2FE30DB84D0CAB45" modified="2020-08-12" version="1">MEFVVAFPEFGVPKVDEQKHAGSKKSSKHPRADARHVVGAHSPRHSVTLCVWPDATTGKTFAIKCIRRHDLDAKHMEFLGQEIDFLKMLNHPHIISLEAVYVDREGVYLVTEYMAGGELFDRIVEEAYYCEDEARKIVRVLLEALKYCHDQHVVHRDLKPENLFLASPTDNTTLKMGDFGFAAYAPEPTLRGTCGTPSYVAPEIIAGQPYGKPIDVWSLGVITFILLCGSPPFHGSTHIELYSSIRRGVYECPKDLSTDAQDVLAKMLVVEPTGRSTVEQLLDHPWIASDASKTPLTRTIEELHKFNMQRKFRSSVRVIQAVHTLARSTTPTALMTRPKASKDAATKRKSWFQPWRIFSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W9S1</accession>
    <name>A0A6G0W9S1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_017321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000293">
        <property type="protein sequence ID" value="KAF0723870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W9S1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016102"/>
    <dbReference type="OrthoDB" id="10329419at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0723870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="153" mass="17187" checksum="BC9049199B8EDCC5" modified="2020-08-12" version="1">MLATYPVQHPSPVASPMPLRLSKSLAMPSGPSNLFARHEITRHEINLDVLRHLAEEENDAFSDDESDGVDSERGEEDDDDSNAEETDEDIDTFDTVLVPLNLPSSYLSMIHVKSPQDQPRTPPMSPHDDSWTLVDKSPTFECVQARRDSWSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WAU3</accession>
    <name>A0A6G0WAU3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase M20 dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_017734</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">The Mn(2+) ion enhances activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000309">
        <property type="protein sequence ID" value="KAF0723394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WAU3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003597"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.360:FF:000001">
        <property type="entry name" value="N-acetyldiaminopimelate deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014:SF63">
        <property type="entry name" value="METALLOPEPTIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G09600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PEPTIDASE M20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="4">
        <location>
            <begin position="200"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR005962-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0723394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="463" mass="50474" checksum="9DF5C4F16791779B" modified="2020-08-12" version="1">MATTTTTTDFDAFFAGLAEIRRHIHSNPELGFEEVKTQALVRDYLINQAKIPAEQIKDCGKTGLVVDIFAPTEGPKLADGALKCVAFRGDMDALPMTEHNPQLAYESKVPGTAHMCGHDGHTANLMGFALLVQQRRHLLPPHSIVRLLFQPAEEGRFGAVAMIKDGCLDGVDEVYGYHNMPFTLGNIQVKSGPIMAHGGTFSITISGPGGHGSAPHVTKDPIVAAGQIIMAMQTITSRSLSPHDSAVVSICQVHGGEADNVIPSSVRLSGTIRDFSPAVSSTINQRMATIVEHTCAAFDLKGEFEMKERYPVVVNPVEQTTIVESIARRIIGSDRVSAQGLPLCGSEDFAFYLHQRPGSFFFIGTKGTTDGHNRNNHTDTFDFNDQILPMGARMFLELINHRFNCAIYSADELGQMTAPKVHNWQTLRIPTWFPSQKDAINSSMELLESTDVSQQACQGLNTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WBI4</accession>
    <name>A0A6G0WBI4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_016630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000264">
        <property type="protein sequence ID" value="KAF0724756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WBI4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013419"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="15"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0724756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="133" mass="15669" checksum="3D3E56629C0FDA8C" modified="2020-08-12" version="1">MVDEARPILPREQTLEDFKLDYQKALRALRNENDTLLTAQEKRTAWEASHRDWSSTDGEIMALENLIQMRTDRCDQLEQQCQKALLRIKEKEANQRCQYNDLIDTEQLLKPFAKFWEFLASYARTSTSKAKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WBM9</accession>
    <name>A0A6G0WBM9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_017510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000298">
        <property type="protein sequence ID" value="KAF0723659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WBM9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011427"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0723659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="174" mass="19828" checksum="D7322168C9F1553E" modified="2020-08-12" version="1">MNRDILQVMRVMLREFRLVDHQWDYLLPVVQANLNQTPVPSLANKSPMEPFTGLEPTTPLDVIVLGVDEGLRDVELSSVDVRSSLEELRQSVQAVHKHVLQKNETRAQKATAATANAEACNVCEGDYVLWSRVDENHHPKLLVTWLGPYRVTEVGEYSVEIKHLLTKERRQAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WCD3</accession>
    <name>A0A6G0WCD3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_016337</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000250">
        <property type="protein sequence ID" value="KAF0725105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WCD3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020270"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026131013" evidence="2">
        <location>
            <begin position="19"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0725105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="269" mass="29608" checksum="9B72C09FBE9F801D" modified="2020-08-12" version="1">MRLVVAMTIVLSMFGVQAERILTTCRNASTGNSNPCVNDTVQGKTIDLPFTTGWTEGYFTYDFSHLELTSIETWPSMPTIIDLSSNNLTNLQVAASNFPYYDIQVGIIDLRGNPNLVLTVDSGVYSRLNYNTFYLGMDQPSNSMAALKACWGNQSFVRPIQTFALHYSIGGLGYGYDNDWKLVNVCCLGCTEPYTLVHTRAPTPKPTRGPAFGIENPKARTGVTVIVVIASIALFALLVTLAKKFIDKRRLARNPTPTTTGQAPYVEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WCW9</accession>
    <name>A0A6G0WCW9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">endo-1,4-beta-xylanase</fullName>
            <ecNumber evidence="3">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ae201684_016306</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000249">
        <property type="protein sequence ID" value="KAF0725154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WCW9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012724"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490:SF88">
        <property type="entry name" value="BETA-XYLANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026085402" description="endo-1,4-beta-xylanase" evidence="11">
        <location>
            <begin position="20"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="12">
        <location>
            <begin position="19"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="GH10" evidence="13">
        <location>
            <begin position="105"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="57"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="58"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF0725154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="418" mass="45012" checksum="6DD3207078090E21" modified="2020-08-12" version="1">MKLGVVFAAVASSVALVQGQVAVWGQCGGQGYTGSTVCASGSVCAAQNVYYSQCVPGSSPTTAPEPAPSTSTVSPVTPKPSSSAATPKPSTSTATTNPPSSPTATPSPPSSKSIYFGTAEDNPTKYGTIIPDNFNLLVAGNGMKWDAHERSKGVFDFSNSLKLIAYAKQNGMKMRGHCLVWHNQMPRFYCSNFVNNGCVSTTLTATELWTAIENRMQKTFAALNDPTIIAWDVLNEAVAEDGSGLKRDVFCNTLGPDYVTQIFTLARKYAPPNVKLFYNDYNCEATSAKSNACFKLVSDLKAKGLIDGMGFQMHLSTKYGENSQISGQAALFKRYSDIGVTIHVTEMDIGASDFTLQAQWYGKVATNCQQNPMCEAFVVWGVTDRDSWRPGTTPLLFDSNLKKKPAFNACYDVIKKGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WDL4</accession>
    <name>A0A6G0WDL4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tudor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_016628</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000264">
        <property type="protein sequence ID" value="KAF0724754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WDL4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003825"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tudor" evidence="2">
        <location>
            <begin position="101"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="2">
        <location>
            <begin position="475"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="2">
        <location>
            <begin position="537"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="2">
        <location>
            <begin position="639"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="700"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="709"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0724754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="750" mass="83026" checksum="CBA72C1C0ED3CA06" modified="2020-08-12" version="1">MPDNTARPSSPSKSMLPALAKRSNTSLRIEISPPRRPPPGRRLMKNATSRSQITKLPADASQKSLLTAKSRNGDISTTSLAIDLSQKNQLSLHESTERLDSRWQIGDYVSAKCHDSEEYFAGHIQGISDSGDVYNVLFDDLTLDKCVPLANIQGLVDSEGMKQELNYCFTDHLDDQSDISNVEAVSKRSEGGPNKQHEASNVRRVDCMIYDDLLDTRITTANLAFATSANTPAHDTRSATQKQLQRIQAALQKMNKPPLLRKGSSSKFRYDPSTPANQAFTAQQDVIVCHDGKIHSNVAISDIQPCWPHQELLDQCRELAKSIDVLYPGAKVLHSVHDKLVPCTIRRRRNVTCFDLKIDGSIEAKTKILVDALVALPQRVQDRVRITDQFDIEAAGKWFHVHEKVIVHDLDVGVSNHGIITAINNNKTVVVDYDNGEVDSAVPPAYLRKADASIKDAGAFMAAFNLDHAFDMGETSYNVDDWVIASHPLSNLYEKGRICRVFSNGLVDVQFADSTISKQVAVHKLRRVEPTRVAKPPSFSVNDYVLAYAPRFSKYCTGRVQAVVAGAYRVVFDYGEIVDRIPHDYITTLEDTAVLSPKKRITRIWKSSNGYEDDQKIPCNGDVSTHKAVCGSPLAGQKKPVAVGELVMAQYSGSAKYFGAIVVQVRSQEAVDVAFISSEAGTAIPLDKIFTIDKRHCQPKQFQVTSSPRQKESHQTKQESPTKPDKNSKPPPPHATSVLSRVRSIFFPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WDQ9</accession>
    <name>A0A6G0WDQ9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_016098</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000242">
        <property type="protein sequence ID" value="KAF0725457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WDQ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013154"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0725457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="129" mass="14537" checksum="53A113563E425065" modified="2020-08-12" version="1">MVHYEIAGCVEHSDYTICERLLDIMATVLPDITVTKEPRSLSQWPPRALEIDQTFGFSVIGKRDVKVAQVLVWRLGRLAAHRAEEFQLYVAEHYGLALDLSKEQIEAYTAANVLEVVGETPQVVDQPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WE70</accession>
    <name>A0A6G0WE70_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_015781</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000232">
        <property type="protein sequence ID" value="KAF0725816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WE70"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004879"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0725816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="328" mass="37396" checksum="79ADA887A82F0F3E" modified="2020-08-12" version="1">MDKRRAANDAYSKAWGWLAQLWRSEAAHGVLQNQLDVTMQWLNDVDSSEVPCPRKGYVVFMHMDRSEVRKDYMDTDEAHEIVENTVERIISEMETFLPQSYWNRIMTTKTVPEASRQLLRDRLVDHFQKTLHFPYLTARDQDLIVRATVAIVADAMGDTKLDDILTRQDTSISLVRIFIQEAMGIDKVDKLPQDVADMVNLPFPVPDRWLKWGIRKGLGVLVSILNDAVDDSLAQCFGPAPSYDIATTEAFQAALRANVVERVHQKFALFFIPSFVEQLFIKQIVETYFELCVTKPRIDVAVDALLLPSSDDSGHDFNMQETLAADTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WF25</accession>
    <name>A0A6G0WF25_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_015666</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000229">
        <property type="protein sequence ID" value="KAF0726001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WF25"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009525"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="5">
        <location>
            <begin position="270"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0726001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="458" mass="50962" checksum="2AF22312D561EDDA" modified="2020-08-12" version="1">MTKSTFPLPRDFFRSPPLSAGEVRRFIQLGEQSCKQAIHYSKIKDGPIAWTLESAFDNTQVYSGKNPQAPPQVAVWCGATQIRATIEEVVYRLKTESTDEYIEYSRTFAKDVIDANNLYTVSPATPDNPHCATSIKWFAQGSAAPSLIKHRDYCYLDSCCEFKIDGRRGWVLAFKSIVMPNCPDLHSALGIVRANIFCGSVFLESVTRPGYLDYVRTWHLDCKGKIPKWLYSRSIKLRCIAMRNFSLLLQESRLRGSIPTLLPNEELVSHSDRSKCFACSKTFHFLSTKQNCRACGEVMCRNCIRWFDNKEARVSLCVSCSVVPVNEDEFQANSASHSGSLDADEAVLTGSQATDSDMLNLSGVLKDLSLVRSTDGNSTVPSFDDSVLFHYGSTIHEDETPLLEDASQSQRALAAKLQTAPVPAVTQMSRSQSVRNDLIPLPDNLPIGSLRSLSLVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WFE5</accession>
    <name>A0A6G0WFE5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_016315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000249">
        <property type="protein sequence ID" value="KAF0725163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WFE5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014725"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="1">
        <location>
            <begin position="2"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0725163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="146" mass="16177" checksum="09947B493F5DC916" modified="2020-08-12" version="1">MDGGSSHLSERIVETATQLQIILLCLPSNATHLIQPLDICVFSPFKRGIRRAIYNYMIENDDATTIPKSNALEIASCAWKQHIVGRTVVSGFSEAGLWPVDHAKMSARLAKFKEGGLPSYLSYCDFRPNLPISGDISNRLQIDQTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WFI6</accession>
    <name>A0A6G0WFI6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_015622</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000227">
        <property type="protein sequence ID" value="KAF0726072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WFI6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009534"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46347">
        <property type="entry name" value="RING/FYVE/PHD ZINC FINGER SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46347:SF1">
        <property type="entry name" value="RING_FYVE_PHD ZINC FINGER SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="8">
        <location>
            <begin position="33"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="41"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0726072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="302" mass="33922" checksum="953FEA44675D0C67" modified="2020-08-12" version="1">MEATNDIVLESTAKYDRVESPKQQLPPSTRKEDEEGDKPFCYICLDTSSGEENSPDELLAPCSCMTHVHRKCLDHWRATSFTYNCMTHCPTCQEPYEFEPIEGESPEEIKKQISRARWGRALLVLLVILFGSMIIALIDAGTPKFFGLHWNALNGQIYNWIGLTSVPRFVIYFLLSLAMTVLITCLVLAIRWCWRCRRNGVRASGVYRRADHRAVDADDNTYASVCWCNVSICDCSSSDYGEYAIIMVVVVAICAVLAGIVLIFVALVGGVGSVVDRKGEQRIRTLQVQEKRVKNLRPLSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WGD4</accession>
    <name>A0A6G0WGD4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phospholipase</fullName>
            <ecNumber evidence="6">3.1.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_015644</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14445"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.4.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the phospholipase D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.4" evidence="6"/>
    <dbReference type="EMBL" id="VJMJ01000229">
        <property type="protein sequence ID" value="KAF0725979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WGD4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013891"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09141">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.870.10:FF:000011">
        <property type="entry name" value="Phospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016555">
        <property type="entry name" value="PLipase_D_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896:SF76">
        <property type="entry name" value="PHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00614">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009376">
        <property type="entry name" value="Phospholipase_D_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="8">
        <location>
            <begin position="479"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="8">
        <location>
            <begin position="776"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR009376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0725979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1081" mass="124849" checksum="B5582F526BF9683A" modified="2020-08-12" version="1">MHLSLDCSIESPSSENAEFIALDSPSNLYDPDDPFTNIELRLPEAPKIRVIQVDRIDGFFYKYNMFVVEISLPGLTWRIHTTTARLLQLHIFLQNALHFRQLFQFPAGLFTYHTSHISDEELSAQVETYLANVLSHKSLWKHPRVLAFLEYSALRFDQRYGESLVEGWVKMRYVPSRKGTLHGRYSFIGFRFTRDNLIRITEIIVAVGLCVIIPFGIFWLFVAMSSAGTISSLGTGYVVAASIISSIPGLYFLVIMYQFLLRHRRWMVIKPNCIAFFESVRSTAPSHVLLFQPHIAITKSTLMGNGLHWMVNGLHVTSPGAIIEVDFQYKGQCNHFYEMLLKIVSESEYTSLHKHNSFAPMRPAIGPNNAVNYAQHLVDGEETFGLMCRHLRLATDQIFITGWWITPDYPLVRTSHEERLQSELVVLLREAANRGVQVYILVYREHHLVLPNDSKFTKESLRGPNIYVLRHPDFVLIPQFWSHHEKIVVIDQSTAFVGGLDIALGRFDTPAHSLTDINKNKLWRGQDYSNPRLKDFVDVQHIHTELIDRQTVPRMPWHDVHCRLEGPVVLDVARHFILRWNFTVQKKYMTLATRSSGRHRHRFTAILPFLHQPVSAPTRTHEGEQVHCQVVRSLSPWSGGIKTEKSIQQAYIDNIAEAKRFIYIENQFFVSGFDSDVSVSNRVVEALYQRIMEAHEKQETFRVMFIMPLLPCFEGAVTSADSANLRAVMHWQYSTICRGGNSLLERLAREVPDPSQYIVFFGLRQHGILSGRVVTEQIYIHSKIMIIDDRVTIIGSANLNDRSLCGDRDSEIAVVLEDSTMEFANFNGKQCSVGHFGHRLRNKLFEEHLGTYMEDPISERNWARIRRLANANTDIYERVFQCFPTDTFTSYFNSVPERNMYEDVRIVYENQRFAWGSGWSADHLLFGERTAWSDAKGIPFDSFTPSGSWQVDVSEGHCDSEGWQYAFSFKAFKKDKDKRAVPLWYRWVRRRRWILVDHAPPNGKSLERQDSSCVDLKKFLRKLSTRSMSLQIDSDRILSPDWVSPEVEELSKVQGQLVEFPLEFLRDCDLRPLILPKNLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WGP1</accession>
    <name>A0A6G0WGP1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glutamine amidotransferase type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_015429</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparagine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000219">
        <property type="protein sequence ID" value="KAF0726314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WGP1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004654"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051786">
        <property type="entry name" value="ASN_synthetase/amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43284:SF1">
        <property type="entry name" value="ASPARAGINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43284">
        <property type="entry name" value="ASPARAGINE SYNTHETASE (GLUTAMINE-HYDROLYZING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3 5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2 5 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="9">
        <location>
            <begin position="2"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="6">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for beta-aspartyl-AMP intermediate formation" evidence="8">
        <location>
            <position position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0726314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="668" mass="75039" checksum="CC0B5DC63951B6C6" modified="2020-08-12" version="1">MCGIVAYLDFSSTASVPTSPPELGPALDLIHHRGPDGQGVWTAPGVGLGHARLSIMDVQHGAQPMHDETNSIHAVVNGEFYDFEAIRADLEGQGHVFKTHSDSEILIHLYKEHGLNCFDYLQGEFAFVLYDSIRQRLLVCRDRYGVKPLFYTVVNNRVMVASEAKAFLAMGWKPEWDMASISDSGWLADTRTLFRGVSKVRPAGYLTVTATGTITTDIYFEPDYPDKTIPDPRSVDEMIEGVRARLLEAVRCRLRCDLPVAVYLSGGIDSSTVMGMALSILRERNPDATLDVFTIAFDDRIVHGTNYDESPIAERSAKHVNARFNVFHATQEAMTDAFDDAVWHWEAPILNFNGTAKFLLSKYVRDAGYKVVLTGEGSDEHFAGYAFFRSDFLTEPTSPPSLSEAFRKQELAQTRATTREMLSEAGFGSVEGFVEGGRQLLNDISTIQGMMLASSLFPSKILDKSLSSNPGEAFALSLTAVERQKALTKWHPLHTALCVETRSFLPNFLCNHLGDRSEMAHSLEGRVPFLDYRLTTYVNSLPPQVKIHDNETTGAFTDKWILRQAVKRFVSQELYERPKVRFLAPPSEFDPEEYHWKKIKSRVTQEAVERLGWMDWSFVDSLMTRFIQTNDRIAQDLLNIIMSFIVIQERFGVAKWTRSSLSAVQPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WHS9</accession>
    <name>A0A6G0WHS9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_015135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000210">
        <property type="protein sequence ID" value="KAF0726739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WHS9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005998"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0726739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="115" mass="12941" checksum="014AE34EBEBC225F" modified="2020-08-12" version="1">MMAEYVNSRLKDENLHHWDQTNAKTRFESYMRAYKAAIAWDSSTSRGQGLTSKDIINGIHTIAAKLDTLCFAYQRIKTLFGARQNINPSYVAEVGAVASSFQENTIDDADYPESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WI75</accession>
    <name>A0A6G0WI75_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_014909</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="VJMJ01000204">
        <property type="protein sequence ID" value="KAF0726917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WI75"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46077">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TOPORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46077:SF1">
        <property type="entry name" value="TOP1 BINDING ARGININE_SERINE RICH PROTEIN, E3 UBIQUITIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="40"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="151"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="158"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0726917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="217" mass="25339" checksum="7A47C0C3C1D695A9" modified="2020-08-12" version="1">MPGRSRFFAPKSEAPRQKDLPGEGTNYERNEEIMKEEPTCVICLEGKKNQSFIDCSHAFCHACIVEWAKFSSSCPLCKSHFQVIWNVATKMSTSVSPVQRLETTEDTFEFAPSDHTYGYDTNDGFVVPDDFVEFDDSTDLELLEVQSRDDNMSGTMRLRSRRQRRLQRQRHHDEVSLEDEQITQRRRSRRLIIHDDDVHICERSRRVSKYFCKSSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJT6</accession>
    <name>A0A6G0WJT6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_014510</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000194">
        <property type="protein sequence ID" value="KAF0727489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJT6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001684"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF17">
        <property type="entry name" value="HOMEODOMAIN INTERACTING PROTEIN KINASE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="116"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="611"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="611"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="626"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0727489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="644" mass="72991" checksum="BD169E5A300EB880" modified="2020-08-12" version="1">MNCREAHGKAEPRESKKSHSTADHVSKGGSNRRASNTNPTEAKAPRLVVKLTTELAQTYSNCGLPCHSQPKTTRRVLTTNSQVVGNNGWDNSDNNIVLRVRDLIEVESSWGYARTFVVLDLLGQGTFGQVFRCQDVVTREVVAIKVIRNHPSYYKQALVEMQVLQLLTSMTCQEGKEHIVDLLDYFMFQNHLCLVFELLSVNLYELLSQNKFRGLPLTVVRGFALQILKSLIALSESQIIHCDLKPENILITGNDRLFPLPSPPNQELRQVPLIKLVDFGSACFENGTVYSYIQSRFYRSPEVLLGLPYSGAIDMWSLGCISAEIFLGLPLFPGASDHDQLRVIIDTLGYPPASMIRAGSNLHKYFKVTNDNEFVLKSAAEYAQDCQTKIATSKRYFKHSKIPDIINAYPIRRGISEEERSKELQGRAAFSHFLEGLLTLDPSSRWSPCQALSHPFITGAPFSPSYRPRSKTKALNFYPPMIPMSQSWFRHSAPQNIPRPPPSSQNTLPMYSWSCPYPLPSEIFMYSERQDFVQCAPIASNPPRHPANSYITDANYFHNQAEHIGAEWDPFFMQSFEESIAAMSLPAQSNRFKNEKQKQSDKYFVNSKHASCSTQASEPSQENQTYHRKWRRRKKKTLESSTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WKG2</accession>
    <name>A0A6G0WKG2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_014276</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000189">
        <property type="protein sequence ID" value="KAF0727762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WKG2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020630"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017110">
        <property type="term" value="F:nucleoside diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009134">
        <property type="term" value="P:nucleoside diphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF83">
        <property type="entry name" value="GUANOSINE-DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026243051" description="VWFA domain-containing protein" evidence="5">
        <location>
            <begin position="24"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0727762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="487" mass="53349" checksum="29CBD21B0E88D0BE" modified="2020-08-12" version="1">MAPTTSWWRRRFAIVSAACLAYAVGSGLPTPPTTSSGCRVIVEANASATSVSLFLPGGSTDSSDLLVLDGFASVPGDLAKQGPSTAYNSIKTAFHKVVERIPEENRPMCSVHLYATGSMRSLPSEEQKAIYDALAVDFQKDESVPLVLERNHLETLTADEEAYYVVLSANILAKRVGSDLEPTDLELYGSLDLTQASSQIVVDVEHRWRYNSRKKSFGSSRPLRRIDFFALTFSNFGRHSLLAQVSSLLEAKNSTENPCLFKGSNDDANRTGGGDAVACLQLVQQLVDTSNAKCATDTYCALDAISQPRLSGPYFAFGDFYRMALFAKDVLHLTTPIPTVPFDFPTPALAEITQAAKVVCSEPFDRVQALPSADSTRCLDLCYTSVLLKQFGFTDDEKRVMYVEELHDEPIRWTRGVYWSLQVEARQAYETALGDYLSAQVDMGLPVGWNLALLVLVFAIVALVNLVHRASNNGTTHALEFVHDASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WKZ3</accession>
    <name>A0A6G0WKZ3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_014067</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000184">
        <property type="protein sequence ID" value="KAF0727956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WKZ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004713"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0727956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="255" mass="29423" checksum="4850AEF52763468C" modified="2020-08-12" version="1">MSLDRSNIFTSWLNSTTLKSKVRSSYEVIAKYYSSVLIQDVTDVKWLRKHLNPAVQVEWIAREFPIPQEVLNEWTELRITRLNGVFYKDDTSKLTSVLPRLPHLSSFEMEVADTFDYVCPLIARSTQITDLKLVTELDGQLKESNVLDLVVWFSSQPVRKFSLGGYHEWDDIDIAVRQKYYEAMVNCSTLDELVLDASGTNDLDFSKFTFSMRSLEIHCPNHFFFESMAGRLEASKVADLKIFASFVKEISIFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WLL2</accession>
    <name>A0A6G0WLL2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_014018</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3B1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000181">
        <property type="protein sequence ID" value="KAF0728192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WLL2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005923"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000039">
        <property type="entry name" value="Splicing factor 3B subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000069">
        <property type="entry name" value="Splicing factor 3B subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000541">
        <property type="entry name" value="Splicing factor 3B subunit 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054573">
        <property type="entry name" value="PP2A/SF3B1-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015016">
        <property type="entry name" value="SF3b_su1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038737">
        <property type="entry name" value="SF3b_su1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12097">
        <property type="entry name" value="SPLICING FACTOR 3B, SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22646">
        <property type="entry name" value="PPP2R1A-like_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08920">
        <property type="entry name" value="SF3b1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Splicing factor 3B subunit 1" evidence="9">
        <location>
            <begin position="214"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like HEAT repeat" evidence="10">
        <location>
            <begin position="1003"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="31"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="100"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="151"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0728192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1221" mass="136382" checksum="0616D79A5E7CFF9F" modified="2020-08-12" version="1">MATNRDDAEKISLSSAGKYFDSHIYDASEGDKFAGYSHTLDDDDVEEKTRRGGSRAGAGNRDGLIDENYDPFADKEYREANGSGLVNSVILERESDYQKRRLQNQVLSPTRQDPFAKSGDGGSGSSFKQIMHNQTLDAEREEVIRKIRKQKEEAAAASVVKQKKRRWDDTGSANASGGEGATTEEESDWDRASDTDGKSGSQWDATPVASDMPTPKKKRWDETPAAAPTTTTIEKKWDATPQAPSSFGGADATPTPGRKRSRWDETPMMDMSADRTPMMTPGGSLATQVMPEVVQRLRWEREIEERNRPLSDEELDAMFPSTGYKILDPPASYMPIRTPARKLMATPTPMGQTPGFQMPATPAPADYGLTGGETPAGGDMPYIKPEDYQYFGKLMEEIEDDKLDPETAKERKIMRMLLKIKNGTPPQRKQALRQLTEKARELGAGPLFNQILPLLMAPTLEDQERHLLVKVIDRIMYKLDDLVRPFVHKILVVIEPLLIDEDYYARVEGREIISNLSKAAGLATMISTMRPDIDNSDEYVRNTTARAFAVVASALGIPALLPFLKAVCTSRKSWEARHTGIKIVQQIAILMGCAVLPHLKQLVEAVGHGLVDEQQKVRTITALSLASLAEAAHPYGIESFDSVIRPLWKGIRQHRGKGLAAFLKAIGYIIPLMDANCANYYTREAMVILIREFQSPDEEMKKIVLKVVKQCASTDGVTPSYVQTHILPDFFRHFWVRRMALDRRNYKQLVETTVELANSVGAAEIIGRVADDLKDESEPYRRMVMEAIDNIVQNLGVTDISTELEEKLIDGMLYAFQEQTSDDTTTLLNGFGVVVNALGIRANSYLPQICGTIKWRLNNKPAKVRMQAADLIGRIAVVMKTCDQEQLMGHMGVVLYEYLGEEYPEVLGSILGALKAIVNVIGMTKMTPPIKDLLPRLTPILKNRHEKVQENCIDLVGRIADRGAELVSAREWMRICFELLEMLKAHKKGIRRAAVNTFGYIAKAIGPQDVLHTLLNNLKVQERQNRVCTTVAIAIVAETCSPYTVIPALMNEYRVPEMNVQNGVLKAFSFMFEYIGEMGKDYIYAVTPLLQDALMDRDMVHRQTAATTVKHLALGVAGLGCEDAVIHLLNFVWPNIFETSPHVIGAVFDALEGCRVALGAHVILQFCLQGLFHPARRVREVYWKIYNSLYMYTQDALTPAYPMIEDDGENNYGRTYLDLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WM53</accession>
    <name>A0A6G0WM53_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_013783</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000178">
        <property type="protein sequence ID" value="KAF0728420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011044"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1387"/>
            <end position="1408"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="320"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="470"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="538"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="630"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="732"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="974"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1527"/>
            <end position="1660"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1803"/>
            <end position="1830"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="2125"/>
            <end position="2159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0728420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="2832" mass="322211" checksum="C777821C5C1122F3" modified="2020-08-12" version="1">MNNEEDGELQYLLRSMQNMSKKKNVKAGVVKQAKPTSGSFKKPTVAQTTTAFNDKQPGNLSFVQQLQVKYTEVKHALDVQHAQCEDLRQCVAQLVQEKAQMAIQSEQLHNHIESRDKEIKTLRAHVQDLYDVQQQLRADKLQTDIQLQKALQFVPNDDGAVCVCHSNAPVIAWHSHEETVVENIALDTSLVQSLRDEIKILEEQVLRQASELANAHQAIVADASRVREMEEAMMQWLTILAPLDPNLDNQEDEVNLTSTIATISTTVGYLVDSFSQSQATSTSQRSRIRLADDPTMPEWLVQALSNVEETMDDASHALDMDVLHMELAALRRSLERKDDEIDAFERMVESMQGELARQPMSLRMRMTTLILNWTKDLRLASENLNNYGTPWSIEKITQTRPFQTTTEFVKSTQDLVVQGSPNDIINSAKLQNEWLEMLAEDFVMVYDHCRAKCSQVQESNKICQALHLSVSRLEGIAKEAEEQRKHVIEENSSLLQEMTDVKSHHDESNTMLQNIICTTKVAWQADIETHRQNLELIIQEHNQDLAIKEDYFDELQNKIKHMQTCMDTLQAAVNETTCAKKRAEDSNLHLANQIYLLEDELTAAISQGQSLVEITKMQHEDYFTRAAVALELHTSRALDLEETLQNAIQRLESSLGDLQSKMDAVTDSEQLMYLENEHLRTKVTRMTRDLIDAQDYAKMMRELQQTLQQDVELWKMQYSQCRSNEASMIELNTKLAHDLEQIERDSAEWQEQAADLIEMQRNDYETRLEITNETFKEKIVSMMDKLEALRQQILQLESNATIKDREITAAERAKFIVEEANTKLSSQLNEVSKKLHDTTNYLNARMQVSGNREQMLLGEVSAWKFHCFELRSREADLVKLNGQLTDDFKREQEESRLKQKQTAEIKALLEEDFAMQLLNTIESHRETVKCLLQAQTKLEMKMKCMEITIAEVSGRLDEEQLAKNVTERTCETTLVELQEAKTELSLMYDGLNNKQIELESWRAKYVESRDNEAAMRELNNILSQGIKQMQEDIAAWQDQAADVIEMQQQDHEARILLIHEQHTTKMSNLAQSEGKLQCEIERLESVVQILRHKIDEMVDAKISVDTKNKSIESKLTQVTVQLVESRNHAKLLQDREENLKCLAKSWEDQYCSNEYIVKSQLVNLNVMLEEEYGVRLASANKSFDQLLEKMTRTEKSLREKALQLKTSMGAMRGTMTRTIEENLALNANIVELRASLDETRFQTMNMQLKLQKEADSWKSECLASRNNEAAAKLFHEQAVLKIHQDYALLQRINMERLEMLHEDHAMRQEKKEISYKNDMLSASNQIDKLQQQVALEMSSKETAMSNAKKWQVEAAELATARDRSIHENYIFLSAELSKLFSPAKHGAISKKDNHRPSQLPGNPATHEAQDACTINSRDFGNLMTTADNIEANTSVGDFAQLHQEAESEQNDSSEQYVMEATDKVVTGHLVHGEPNKGSETANFMVLVQPLIKNLEAYLGDEQRRYTKQLQDIDEQYMKNKSFLDAQIQTQHQELDHFRDQCANYEELNRKHEAEKLLLSQSIEALEDQLGRLQIELENKQNKITKLEFAVVSAENNVDTSLELQHASLLEVAAYRSECEHLKTLVDEMNSRMSEFKRERLEREEVLVSSMQEELRTLETTYKNQVAHWKQVALTNESQIIKWKHVVGSTQLEMHEYQTRQSTKDSFVCGHSMPDPSPNRRIDLNVKWLHALRSAQLEMDMYKELSTFELKKAMESFTKRLAESTAYLTLEHNRIVAELAERLCSEQKLTARISNDLAMSMEKSRAMSNEIEALKVEHDDLHRRCKENDQKFDKARLEWIHQLRAVQLEMDCLQDSKLQQDQQFDGLVEENHRLQCHVEDIISNFHESNVASSRQKKISDEEWQRRIQALEYEVVAAKRASHAAKIESGEVVDKLRKLNVEHSRLRKSHKDLLVDYGAISGLIDGLVCTTTSWRQYAQTIQLASPAYPHEPHVESGSPKDSKMDSKIISSPEIVRREAHPSSIPAVVNSMECGRIDDCNRNVVEMMAPSPYHQVELNIAHELDVSAMPELEWMWHAHESAKQIDMVQDKPLISPRRLSPEETRRQQMLEAINEQLHQCQDIHSQEISLLEAQLLNAETEIQSLQESIVHLNQTNKSYKVEFRHLQQRFLSMHLLTRLQTKSYPLASHVEPTLFGLHQALFAPSTSSSPPLPVNTQGFETVPEENIEAKTLLRDPMHFGLDRALFAHSAKPSSSPSENIYVLETAPEGQIDDITLMWEPTTYGLDKVLFAPSASSSLPSSNDYFMLATIPEVTTDASNFMWAPTISGLDQALFASTASLPLESSFEIDELTSDAQGNTNTWRLAWEQTMHGLDRALFASSASLSLDSSVDIDGEGKTDAGKMIWEPTTQGLDQALFASSALSSPLSSVDFRGLVPIPEERDVIVLTSDSLSGHFAALLQEMHQVCDHLRRCRWSRSDLFARIQSRLKICFPRPNIYSNRDIALGQASELIHTFVALWVESLHHRTPSRGLHDADRNDAVASKSLNMLPKYQRRQRRRGRAKELSPAECSGVMLLHVGATEIQAGILGLPMPLVNLPSPRGLFSKGHLVDIDRFEAAVDSAFCQLGIHPPSYKVVLLHKPTFDSTDKETLTDLFLDGFGVYGLNLTTHAQVCLLGRDLHTGLVVDFGTDSTCIVPIFEDMLLDHALVTIRLGSADIVKCFTTTKAGDMVSTSSSSLLDHPQAPIDLVEAIHACVSKCDPVLHKALYNSIVVTGGPSALPGLASRLERDLNVAVVHVEPFVFQGASLHATHLSPYKWVLKPDYVAHGARIVHAKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WND7</accession>
    <name>A0A6G0WND7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_013416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000172">
        <property type="protein sequence ID" value="KAF0728847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WND7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001243"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051266">
        <property type="entry name" value="CLCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579">
        <property type="entry name" value="CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579:SF43">
        <property type="entry name" value="ZINC FINGER (C3HC4-TYPE RING FINGER) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="64"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0728847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="509" mass="54093" checksum="D1D501962E4427DE" modified="2020-08-12" version="1">MSPVPPPAPAPAPAPAASNAINKTIRISSAAERFEIAAAEACSTFVNCNLVAPSVEEDERKPIDLIVVLDRSGSMAGAKLALCKKTMEFLAQQLTAQDRVALVSYDTHVTTDLALTKMTAEGKAFLSQRVQAIQAGSMTNLSGGLLAGVDAVQQPNRADNGEPNPVKSVLLLTDGQANEGITSPAGLASMLQGVLDPQVSVHTFGYGSDHDATLLGQLADIGRGSYYFVQNVDGVALAFANCLGGLLSVVAQNIKLECIASPGVLIQSVKTKRPVTTVTNQVHYEVDMGDMFADESRDLLVEVQLTPQNPQESMNVVEFRLRYANVVGSSMDKASSTATISRPAIVKNEALNEQVVLQKQRVLAAEAIEAAQAQATRGNLAEGRNLIAAVKEKLETEMAKMPTTSAYMAPLLNDLVDCTTSMATESAYRNHGHGHMQQRMQKVWMQRSNNIEVNDEEELDRAMAVPMAAPALSSAFGSAAPAAAPAPAPGRFGNMAQTRMMKKAFNLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WNF7</accession>
    <name>A0A6G0WNF7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Acylphosphatase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_013436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000172">
        <property type="protein sequence ID" value="KAF0728867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WNF7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010773"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026191554" description="Acylphosphatase-like domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0728867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="136" mass="15495" checksum="4109F02725A63BD8" modified="2020-08-12" version="1">MRWKEVAVNALVAALLADEVDGTPPPFHGFRFELRDPSLSPEKIADQARKHACFGWVQPTPRDSLVGEVRCRGRHGQNMQSWIESNPQANVLVYPSTKIRYHFTSFRVLDRERRTCFQTAPHACEPTLVPPAKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WNH3</accession>
    <name>A0A6G0WNH3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_013352</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SWD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000171">
        <property type="protein sequence ID" value="KAF0728920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WNH3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010840"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037867">
        <property type="entry name" value="Swd2/WDR82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861">
        <property type="entry name" value="WD40 REPEAT PROTEIN SWD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="108"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0728920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="339" mass="36977" checksum="CC45D3A49CF156BB" modified="2020-08-12" version="1">MALAFTDALVSSYGIARVLAGEEDAVMNSVDFHRSGNFCAVSRSDGVVSVINAISGATHKTILTKRFGADLVRYTHHPDCLLWTSQNKAEDHSIRYHSTYDNKFLRYFTGHKKRVTSLMMHPTADEFLSASEDGTFRMWDIRCAEATGLLDCGPSKPALSAAYDSDGLVFGVYTGDNLVRMYDARNFNDGPFAKFSLDEESISSALRPLLQSRQYKGGRVDVHAIQFSPDQQHILLNTSSGVLIQLDAFEGRLTRLFASHSNPSGMKLGAAYSPDGAYIAAGADDGTVCMYNANTGAVTVPAMKGHIGPVFDVQWNPQRHLLASVHANTILWMPPATAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WP38</accession>
    <name>A0A6G0WP38_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7164 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_013119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000167">
        <property type="protein sequence ID" value="KAF0729141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WP38"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006925"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055588">
        <property type="entry name" value="DUF7164"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23741">
        <property type="entry name" value="DUF7164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7164" evidence="1">
        <location>
            <begin position="64"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0729141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="372" mass="43215" checksum="952E501E0AEB966D" modified="2020-08-12" version="1">MQRQSRSRWLMGMLLSGIALIFALSAFTSIVEWRLLDLQKSQATESELFHVLEEDVKSFDPNSESVGIVSFVPAGKTKFINQTNHMLFSSWKFACRSVLRNTRGRTDLFLFAHRDVIDQLPSECIRLHPANMTHLDKMTDHCYIIEHTPSPDDYWFRYSFMFSLTFLADPKYQLMLTGYDRLLRTDTDVVITPAFLTFKPSKFVVGRGGYMIENFTKTKIQELAADLKMTHQGVFNVGSTWFGHSMLVLLMANKMMDVAKFILESPKYNVDMGWPTWHIGVTSMYAGEIVVNHFIPKDNVWINSESIDINCNGRERTAEVYHSHCWPGDQYPGYFNKWAYERGEYSTEKFPRKKLNLSYINDYFMAMVLYGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WPY5</accession>
    <name>A0A6G0WPY5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_012925</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000164">
        <property type="protein sequence ID" value="KAF0729424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WPY5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005971"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01275">
        <property type="entry name" value="FHIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000011">
        <property type="entry name" value="Fragile histidine triad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051884">
        <property type="entry name" value="Bis(5'-adenosyl)-TPase_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039383">
        <property type="entry name" value="FHIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46243">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46243:SF1">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="8">
        <location>
            <begin position="129"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="4 7">
        <location>
            <begin position="222"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="3">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="217"/>
            <end position="220"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for induction of apoptosis" evidence="6">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR639383-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR639383-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0729424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="282" mass="31381" checksum="AA098BEF566C71AC" modified="2020-08-12" version="1">MVRLPQFAVEHNIRAVLLDLTECHTVSASQVVPALIKCGFKVGILSNPQRPLPRAKTTPIFVSTQPQSFLQDATQHLRVAANRSMVVQSLPTGSFSLRVGLSDVLLPEQLSIEAFVQDLLGFSPAFDPNWTHFGPHAVSKAQIFYESSLSMALVNLKPIVPGHVLVIPKRRMDRFLRLDADEVADLWVTAQHVASRLQGHYTAEAFTFSIQDGKAAGQTVPHCHIHVLPRHQGDFKRNDDIYDHLDKNDLSQKEQMNLDAERVARTLEEMAAEATILRALCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WQR5</accession>
    <name>A0A6G0WQR5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_012640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000161">
        <property type="protein sequence ID" value="KAF0729749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WQR5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020460"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0729749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="248" mass="28589" checksum="3FF6711A849FF000" modified="2020-08-12" version="1">MRPFVPVSPCRDETTFEYVAIWANRLLARMALDSTSFPHNYAKFQERVVNFARERRGLKVRLAAETVGAIAVAYQKLKEPPPNFSSRGDTRGRTGPSAARLSARRQRAPRSRSRSTQPEAKRPRREAEQSPTCPRCAMEDDLCLLRDEVAELRRRYDHSEQEFEGRLQGHQEELHMKKLCEESAATADSLKSWASAMDHQRDDFYKKCSELEGLVERLSEERDRVNAHLLALHSKIQLGYSPFEELKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WR13</accession>
    <name>A0A6G0WR13_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_012512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000159">
        <property type="protein sequence ID" value="KAF0729868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WR13"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007263"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22538">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22538:SF1">
        <property type="entry name" value="VWFD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0729868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="570" mass="60587" checksum="06D81F211946279B" modified="2020-08-12" version="1">MTAVGMEQAHTPASFENLESPNRQVVAAEGKSRRFRLIVTAVALLGVVCVAVGAVLVFHQKSHNSSVTLLAAAQATPVLKLTLQFKRKSMYYYGQSSAVVYAFPRTSSSGANLGYDGVLELKQGTTIEKYIYVNDKAYYTKKEGNKTTAASCLTASQMPTFNVVDSTLHNAKVIDSATVGSTTIVASKDCPQGKLLSVAFGGEKFIVCTAGDDKVKQITGQDMNIDVEYLSSLAGVPSLDVPKALDGSVLSCQTIAPKSVATVETKSFSEVTTAFTETLLGTRQESLFGSDCQCKARKPCLFVHGVFNFIEGPLSDTFPLYWGDVHKHVPCCSSIKFVHFDTINQGWNDDSIQNSLCKAALQVSGSSSKTVGPLNLITHSMGNMITGAALATGKCSFSKDVTWISSAGPMKGSEAANLLAEKCLGGGLDIVISKPLEFLGFCPPTRAFASLYYQDTMNAATQKLLIAGQQARAKHPNKKVLCGNDGYGLNTIFSVPLQIVGGWADHNGPNDGVVAVESCVAGLGSDVVFGGDITSTNYAGPLNHEDLAFRNGDGWLGDDRKPVKWLSCAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WRF8</accession>
    <name>A0A6G0WRF8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">Ae201684_012445</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="VJMJ01000157">
        <property type="protein sequence ID" value="KAF0730047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017722"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018491"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020126"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000026">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="11" id="KW-0229">DNA integration</keyword>
    <keyword evidence="15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="17">
        <location>
            <begin position="374"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="18">
        <location>
            <begin position="918"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1274"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1402"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1281"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1410"/>
            <end position="1424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF0730047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1439" mass="160285" checksum="2C13344E136B38A0" modified="2020-08-12" version="1">MLDRAASDQDSHAKVRVKLANGQMIVTDRVLITLPTKIGPFDSEETFFVIDLDDRWDLILGMRWLEKHKPTIDWCSKTLSAPSSSDDTPLGVMSNELTPSSDLKTQLNTRSRRTIEESIDDDVFEHNSIQAVSATTEASGELAETGNVSMLYDSVAITARNTARNQVMFQELEGFGISRDGITKIYASHDAKRRRRLMARAAAWSQALAEETVLPARVADTAVRLTADELILSHCDLEELPRIGEEIVKLPEMSFREFKRAIRSGDIVSIALIQPVDELELNTSSTLDTEVTSGKTALSSYMKTWEDLRTNPYYDLLREYEDVFPEEVPETLPKDKGVRHEIDLVPGTKWCVTRQWPLPREQVDHIDAFFEKRRKAGHVRPSTSPHSSPTFCVKKPTGGWCIVHAFNKLNSATIPAQTPIPRKDVIIDGMAGSTIFSTIDLRDGFYQTLMRVCDIPKTAVSTPSGMLWEWLVIPQGLSNAPATFNRLVTGKLRPLRDFAPSYFDDIYVHSKKSKTCTDLEVHRGHLEAVLEVLRESGLYANIQKCMFGVSEIPVLGDYVGINGCRVDPSKVDAINSWPVPRNVTELRSWLGLATYLHKFSENFASIARPLSTLLSKDEPWNWTQDCQAAFDGIKASLVSAPILALPRFDRPFSVVCDASIRGIGCCLMQVDDDGRNRPVSFQSRQLRAAERNYPVHDLELLAIKYALVKFRIYLLGSKPFVVYTDHASLRYAVKTPHISERMARWFSFFAEYNMTVEYKPGSENVLADALSRRPANLGPETTELSAVYHVHSDLYDRIRRGYRNDPAMKAIMAQLSETTSRSGPTSTLERYSIRDGLLLHQPTRTTTPRVAVPCDADLRSELVKEFHDTPSGGHLGRDKTHVTLARSFWWPRMFKSVARYIAACDVCQRVKSSPSVRAPLQPLQIPGDLWASVSMDYIFGLPRDNRGNTGIWTCVDRASKYLVALPVKASITAEQSAKLFFDNIYCRFGLPTSIVSDRDPRFTSKFWTALFSLVGSRLNMSTSEHPESDGQTERANRVIEDVLRSYAQSRQKTWSSLLPQVEFAYNSSPNASTGFTPFYANYLRHPRLASSMDNSVSNGGKFSWQTSMHSPVWEPSAGEEELPARTIASVKHFVKVRESILLQVQDNIAEAQSRQSRAANKQGRRTTAFALGDQVLLHYSLVPKAILGNAKTRPQWFGPFPITKVISRTAYRLALPADWQTHDTVYVGKMKAYILQVAPAPELSTAQPHEQLAVQPQAQPNLVDQSLVERVGPRRTTRLPSLQGSSASGAQGLDQKLESSSPRSSARAALSQPQALPQAQALLDRTAPLGLEVDSPGRLDVAKPNDAAAGVAQTARANDYAPMKTRASAARDHADATIVASTQESAIATPYAHILPSDESVRTFAPSPTRMVTRSQSRQLTSSVKRGRAKVITRSRTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WS63</accession>
    <name>A0A6G0WS63_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_012273</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000155">
        <property type="protein sequence ID" value="KAF0730272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WS63"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009438"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0730272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="262" mass="30979" checksum="6332897C7C4374CC" modified="2020-08-12" version="1">MKHFVSLNLQNVPEQPLQRWHTATLLGHPQARKLCKEWLTQQLYHNINNCFEVFSCTRMNEEFYGIDVDVFDEGLKCTEMMQQIWPGTMPSCKHFFQHHTASLIFLDPTRISTETTENTRLYRKITDEGVFFNILQGNFVEADRFVVVLRQIENDEEFNSEPYRQRHNMTWLDIRPLSETHVVFSAVSQSSQFFREGQGFVILGEQARTWNIDLTGVPNEKKLDYFRSQHIHQEYKGYSEWRQRIQQVITKTCSTKVAPMSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WSD4</accession>
    <name>A0A6G0WSD4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Spp2/MOS2 G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_012339</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000155">
        <property type="protein sequence ID" value="KAF0730342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WSD4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012530"/>
    <dbReference type="OrthoDB" id="5577072at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045166">
        <property type="entry name" value="Spp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026822">
        <property type="entry name" value="Spp2/MOS2_G-patch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15818">
        <property type="entry name" value="G PATCH AND KOW-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15818:SF2">
        <property type="entry name" value="G-PATCH DOMAIN AND KOW MOTIFS-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12656">
        <property type="entry name" value="G-patch_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spp2/MOS2 G-patch" evidence="4">
        <location>
            <begin position="152"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="193"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="221"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0730342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="236" mass="26018" checksum="438F484EE0D98012" modified="2020-08-12" version="1">MSFSGFALKGKKKTAPKPISGFEKAKKADEKKDIVVGFSTDGDAVLKDPSVANGPLVIPCIKENWGADQEAADALLADIRASSTKDPNAEGSTLVIPIANNDETRDNKKPKLDKDAPLLSRNRIPGMDKVVGDKDKFKHDVAMRPDELDIHSDAFEAVPIEEFGAGLLRGMGWTGKDRIEATGSKVQMRHYRLGLGATPKPVVETKKKKSYIPKPEPRDRSSRKRSRSRSRERTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WSR2</accession>
    <name>A0A6G0WSR2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_011927</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000153">
        <property type="protein sequence ID" value="KAF0730503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WSR2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015871"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000549">
        <property type="entry name" value="ABC transporter ATP-binding protein arb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000011">
        <property type="entry name" value="Putative ABC transporter ATP-binding component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF14">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="375"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="702"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="632"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="907"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="159"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="197"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="219"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="235"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="262"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="298"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="316"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="645"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0730503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="941" mass="106557" checksum="0ED2269F0FBAFC7A" modified="2020-08-12" version="1">MARKRNNRRGDDSDDEPAPAAAAPVEEEKKGGKKDKKKGSKRHDDDEDVEAAVEDPYVQAAANVASKKKDKKKDKKKQSEAEEETEQIEEEEDEDPYLQAAASVASRKKDKRKDKKKQAFVEEVEEEEEEEDPYEQAAAAAASKKKDKKKDKKKQVVVEEVEEEEEEEEDPYEQAAAATASKKKDKKKDKKKQAVVEEVEEEEEEEEDPYEQAAAVAASKKKDKKKDKKKQTVVEEVEEDEAENEELAEATEDAEVQEVEVVEEKKPKTDAEKKKEKKAKSKKAMAAALLAEIEKDEEEKKEGAEEEKTPKKEKKERKEGKKLSNKERRKLKEEAEAAERDAEYHRAANPMDGKQFSVSQQAFTEDANWENATDIHIDNFTINAHNKLLYENASLHINHGGKYGLVGPNGQGKTTILKMIALGELRIPPKIDCLYVEQEVVADDTRAVDAVLKADADRWALLEEEKNLLAELENNPNDQLDERLNEVYEQLAGMNASAAEARARRILFGLGFDSAMQEKATKDFSGGWRMRISLAKALYVEPTLLMLDEPTNHLDLNAVIWLDDYLQKWKKTLLIVSHDADFLNSVCSEILHLENKKLVSYKGNYDQFKEMEVQKRKQAEKAWEKQQKQLRALKAKGTSSSKATDIVKKQREPGARAEKKKAKSSVESAQDSGKTMELLERPREYTVKFSFKEITQLSPPILEVREVSFKYGDGPYLFNNVDFGLDTDSRVCIVGPNGVGKSTLLKIITGDLNIEEGEVRRNGRLRMGVYNQHFVDKLPMGETPVEYLRRLFQDITYQDARNLLGKVGLEGHAHEIKNRLLSGGQKARVVLAELILMNPHMLVLDEPTNNLDIESIDALCEALNEYDGGVVVVTHDARLIEAINCVLWVVGDNDCVAYNGTFEDYKNAILEDIMKKAENEEARIQDNAAKKAEKRAEKFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WT79</accession>
    <name>A0A6G0WT79_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_012092</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000153">
        <property type="protein sequence ID" value="KAF0730673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WT79"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003268"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37736">
        <property type="entry name" value="GLYCINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37736:SF1">
        <property type="entry name" value="GLYCINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="285"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="45"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="289"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="403"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0730673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="412" mass="45492" checksum="45A03C92387D4364" modified="2020-08-12" version="1">MGMARNTATKEDVPKKKDGKKGQKEEAKPAPVDYASIDHPYVVILNKKLRAFKKKQEKIKQLEDSLKGQTKQLNEQQLEVLSNKPFVEKMCVELELLRQQFVETLTSSNSAPISEAGKDEDAAPASDEGDTSSLNHLNEDVPDAKDVEEMVHELDEDLNPAEPAPVANDEDVKLEYVESILKLLHAVSLHQALGHEVPMALDYFVKVLMGGTRPPAEVSFAENLAESLEEAKRYVHKSDKILALDMSYRHLSDTVDRLVAPLKPAEPVVEEPHINFFTESALDKAPVEENIETPAGEDDSYVVVDVEKTETKSARRPNSGNRRQKSPREGAAANGDSHGDKPQKPRKVYQPKVKPSADGVEGGAPRAPRTYAPKGFNDSKSPLDGDKRPANRRPNSKQGPRPKKAEQDAPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WUA5</accession>
    <name>A0A6G0WUA5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RanBP2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_011585</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000147">
        <property type="protein sequence ID" value="KAF0731035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WUA5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018976"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019240">
        <property type="entry name" value="DUF2196"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03833">
        <property type="entry name" value="YwbE family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40069">
        <property type="entry name" value="YWBE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40069:SF1">
        <property type="entry name" value="YWBE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09962">
        <property type="entry name" value="DUF2196"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="6">
        <location>
            <begin position="145"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0731035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="177" mass="18766" checksum="28F25A2885F07CBC" modified="2020-08-12" version="1">MNRQPRRQGNDNRRGGRRQGPSSRQQDGASRGSNTINSRIAPGMSVAVVQKQDQPTGRLTYGVVAETLTNSAVHHRGIKVRLTDGTVGRVQHIQDATGKFPTHVVTAVDDEDGTSAMPSRTLQLQDWIQLPSASHVSAAAGIDGDAADWVCGVCTFQNSGFLSACEMCNAPAPSIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WUX1</accession>
    <name>A0A6G0WUX1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_011522</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000146">
        <property type="protein sequence ID" value="KAF0731262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WUX1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005550"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0731262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="216" mass="24653" checksum="DD7A957115832A54" modified="2020-08-12" version="1">MLSLGLLESTETIESVRHNLSTNFSEGIVCTKFQAASFSHIETAIWKAILFMHSASPLQHFIIRHPLDENTIFVRLKYAIPNCKVKVESALILKRQQVGPRTVRMILRSIANDEADPFEPDSFVCDHCAWFHIEEMDDASYLYKSFVRGNFSGFKPDDVMNLSSMFDGIVLENPWKKTPIPKDSITISTTLFESTFQTFQTTLLSELAKQNIQVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WVN4</accession>
    <name>A0A6G0WVN4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_011206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000141">
        <property type="protein sequence ID" value="KAF0731586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WVN4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012459"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0731586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="251" mass="28635" checksum="1C8E17D4A45F0117" modified="2020-08-12" version="1">MSTPNTSPAHQALSNRLKAQFQQPDSDDEDRNASQDWFVNDVRETPTVIKDDNPSPREPQQEPAQSKAAAGSPTQKRSSFSESEESDQVLLKTKTGFLHLRPIEPSILILELCKSDQSMQKMYGTKYFKVYLPQIVDSQTDFCLYCRKRLGKNKIRFSLSETNISKWNNPSYVGKLAIYKTANGYKYKIVCPKRKQRVVFTIEQDNRKYELKVHFNAHNPFVSLFQRLKPPSEEVATVACLLQASPSIPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WWD3</accession>
    <name>A0A6G0WWD3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_010958</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4G family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000139">
        <property type="protein sequence ID" value="KAF0731859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013944"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253:SF9">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MI" evidence="5">
        <location>
            <begin position="1114"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="265"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="308"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="534"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1003"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="311"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="376"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="456"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="467"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="534"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="589"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0731859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1455" mass="159356" checksum="FF9D9D4512497FDE" modified="2020-08-12" version="1">MSAPPHDTQRFPGHGSRDGNDLNTNQIPVRTSSAPPIDTSYKSGGPAAFIPGQHLNPHAAPRQYTPQANYAPSGGVYQPGQPFYPRNAPPQQYAVSDAMNHAAHTGHHMNANAPPHIPGQGRNTFNPAAGGVPPAQTSRPGASVPMRGPPRINPNVQPFVPQSMAHNQPPAYVPRNGQQPGYYNQMQGAYMGGHMHNQPPMYMPHQMQYPPMQHPMGMNPNVGMGIATHPGQTPMAPAPRPAAPPQREKKVLLIIDPKTKKPINECVSLTSDASEKSDTSTAPSTPAKKPIASTLRATVAEFVLPSSVASPAPPAASPKPPVAAASPKPPAVVPPPVAVTSPKRSAPVASPKRSAPVASPKRSAPVASPKRSDPVASPKGSVASPKAAAASVPSPKPASTTEKSSVAKSVASPKAQAAPASPKSKEPSLVFGTFDVAAEETRVSPKNVSLPPGFHDVPKDEKPNEEVQADEEDTENVEEDEDKDEAPPKHTVPRPVNPQPTKNGKLCYSVEFLFSFREEYVELPAATAEPNSGWLSMEVTNDGPSRSGNRRMDRQASSGPAGPLQRQSSRGNNDKSKQWQRDQTVPRRAGGGGRGGSGGKMRQQASLDDVPLKRREDRWVPQKATSNLEKVMKQVQSIMNKMTNQKFDTLSAQLSEIDMESLEMLSSVITIIFDKALGEPHFCEMYANLCVRLEQHWKVWSFLKIVRNDDNESWYWTTMSDTDAEVVGPFETEDELLENAEEDPLEVIAAPEGLQLKEVRVRKEKFIKVWELDGQLYWSGQSLEDLGERQVLNGPFKTQDDANLNAIKTTSFKRILLNACQEEFEKDNIYETLDEALNKAREEGTLTAEVEANFEEKKMLTKRRMLGNIRFIGELYRKGMLQERIMHECVMKLMGVTRAQTQNAKAIKLVPLHPGAAPDEENIESLSKLLTTMGKDLEVKGTFPGAMAAYFDYLAYLTKDKRLSSRINFMLRDVIDLRNNRWEPRRKELKQKTLEEIRKDAEKELAASQKRPNNPPPRGVASSSSSREMGRGGNGFRGNNPPPPQRNNFALDRSRSQQIEKPGSQGRPTSFSFKGRGGASNAKAAPTPQKPVQIRPQKEIHDQLSQLSEDVTAPLAKKTKSVLEEFVGLKDVNEAVACIQELKTNNASLSSLLVSSCFAKETLKLAVEEKDAVREGMFDALVALQEQKALENDAILYGLEAAILSAPDLSCDVPKIHDHLGTILARLFTPVESLTLEWLVSGFDCESDDEAYQELVDSGVLSGVVGAFLSKIPAKVAASQSSSTFINKNLTSILPSYGRTTGDVMQWLTKFGLNNTLPAIYKAGEVVTTVKQSKKVDDVIVWIESNVSGEMRADSLFAKQTCLFLLSLSNWDIPPADHSNLLMGLCGNIEGQMAFVGGIIQEVTDDKLKPLLNYLLHEHIISDKAFLSWRDSYLRNPTKDNAMERLGDFFDTLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WYG9</accession>
    <name>A0A6G0WYG9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_010274</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000130">
        <property type="protein sequence ID" value="KAF0732565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WYG9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020807"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17364">
        <property type="entry name" value="MFS_PhT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="465"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="27"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0732565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="517" mass="56181" checksum="356F8CBF7F3ED567" modified="2020-08-12" version="1">MAIGQGQRSVAFKDLDTAKFGAAHIRAMLVAGSGFFVDSYDNFVIGLIVPMIAWEYYGKSGLPSSRADGWVKAASSWGNMVGQVSFAILGDILGRKKVYGIELMILICGALLCAFAVWPVNGNPDNVLIMLAVWRFILGVGIGGDYPVSAVITSEFASSDRRGQFIAAVFAMQGFGIICAATLAIIMLAAMQSPIVENTKNIGYVWRFLAGFGAVPALAAVYWRLRIPETPRFTVNVLGDQEAAVRNANQFLQGTAHDNNISVPKPNTAKSFSEAFRTHFSQWANLKVLIGCAACWFFLDIGYYGTNLNTPAILSIIGYGSPTSKGNQKIYDDLWNRAVGTAIINMCGTVPGYWFTVFLVEPWGRKPIQYLGFGMLTILFLIMAIWLDDFKAHYTTLFVVLYSFAQLFFNFGPNSTTFIIPAEVFPTAVRSTGHGISAASGKAGAIIAAQCFAVIAKGSFGFKGVLYIFFGCCLMGFLFSFWVPETKGLTLEELSGDNVEKDVVDDYAESKTPVAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WYV5</accession>
    <name>A0A6G0WYV5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetylglucosamine-6-phosphate deacetylase</fullName>
            <ecNumber evidence="3">3.5.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_010108</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate</text>
            <dbReference type="Rhea" id="RHEA:22936"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="3.5.1.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. NagA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.25" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000128">
        <property type="protein sequence ID" value="KAF0732776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WYV5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003560"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008448">
        <property type="term" value="F:N-acetylglucosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006046">
        <property type="term" value="P:N-acetylglucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019262">
        <property type="term" value="P:N-acetylneuraminate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106279">
        <property type="term" value="P:negative regulation of UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00854">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000023">
        <property type="entry name" value="N-acetylglucosamine-6-phosphate deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003764">
        <property type="entry name" value="GlcNAc_6-P_deAcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00221">
        <property type="entry name" value="nagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113:SF14">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="9">
        <location>
            <begin position="62"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0732776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="543" mass="58573" checksum="F5D0C083FD48F1EF" modified="2020-08-12" version="1">MSLLHDTTLKVENVRVLRNGKLVNTFLWVENGKIMDPQARYWKATSALEYGPGTVVDGKGMIVAPGFIDAQINGAYGRDFSDVECTPEQILQVRQKLLATGVTSFCPTVISSSQDTYAKVLDKFERTNDGHLVKGANMVGLHLEGPFINKQRKGAHKEEVLTDPEEGIKSLEDRYGPLSSDRVALVTLAPELKGALAAITELKQRGIVVSAGHSSANIQQAVAGVDAGVTMLTHLFNAMASFHHRDPGLVGLLGETKQRPFYGLILDGIHSHHSSCRIAQASHPDGLVLVTDCMAGMGLPDGSYELADLKVDVADGRAYLHNTTTIAGSVVQMDACIRTLIEFTNCSIEYALEAATLHPAQALGLKNKGTLAFGADADFVLLNDKLQVVQTYIAGTLVYEASSETGVLPTIRSAFDYQPVAMTHFDLDDDGAMDKAAASGQLHLVKTMAAEGRRCTVHAMDGAATNGHLEVVKYLHSNRTEGCTTNAIDLAASNGYLDVVRFLTENRTEGRTNFAYKAAKEHGHYEVVDYLASLDEDSPTSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WZJ6</accession>
    <name>A0A6G0WZJ6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_010053</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000127">
        <property type="protein sequence ID" value="KAF0732945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WZJ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010724"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011498">
        <property type="entry name" value="Kelch_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF3">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13415">
        <property type="entry name" value="Beta-prop_FBX42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07646">
        <property type="entry name" value="Kelch_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="335"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="526"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="534"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="549"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0732945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="568" mass="63713" checksum="D24EC5CC06E2768E" modified="2020-08-12" version="1">MWTHPIAESGNSAGCRAAHSCDYIEKDEALYLFGGWSGKNALNDVWRFDLTTLEWRLIDVGGVPPRARNNHASAVVDRKIYIHGGHDGSTWLSDFYVFDTETSRWSEVTTSGIGPSARACHTMSKVGGKLYVFGGYDGVHCFNDVDILDLDTFTWIHPIVHGYHPAPRNAHTMSIVGTSLYMFGGHSGAKHLRDLYEFQTETLTWTHLASVSGLFPPGLRGHTASVKQPKIYFFGGYDGRGRSNELYILNTREMRWERSPDALAHQAPSGRQRHSACLVRSKIFVIGGFDGFKWLDDTHVLDICRIEEQAIKQTTQSHLVAHFRELLLQQDATYSDVTFMVQNRPIVAHKAIVAAQSVHFRRMFSSGMLESRQPTIAIADWSYGAFFHMLEFLYTGSVAEMSTESAMELLGLADHYALQELSTLCENYLMHELESENVCHVLIAANHFQSENLKASCMQYLQAHFHQVVSTRGFEELGEYPTLLLDVTRASMSTQKHKPAQAIDSSGSFVSYAWSSVSQLLNHFVRPGNGIPMQEEDEEGDDDDDEEAADARSTDEQSHDDGSIYTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WZM6</accession>
    <name>A0A6G0WZM6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_009854</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000126">
        <property type="protein sequence ID" value="KAF0733028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WZM6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001762"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486:SF5">
        <property type="entry name" value="ADENOSINE 5'-MONOPHOSPHORAMIDASE HINT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486">
        <property type="entry name" value="APRATAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11969">
        <property type="entry name" value="DcpS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="6">
        <location>
            <begin position="4"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="4 5">
        <location>
            <begin position="101"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="3">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0733028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="143" mass="16569" checksum="4E27AD4A6D146039" modified="2020-08-12" version="1">MEAPECVFCNPIDPGLILYQDELVVAFQDIRPRAAIHVLVIPKQHIQNTSKLTNSHIALVEYMVQVGKTVLADQVDHLQLKSPRKDHIFGFHQAPHNSVDHLHLHCIVPPFAKWWKRYRYSESSWVGHFISAASFINQLHQYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WZN3</accession>
    <name>A0A6G0WZN3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_010092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000127">
        <property type="protein sequence ID" value="KAF0732989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WZN3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013466"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0732989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="153" mass="17375" checksum="0D6ADB7C3BCF3CE6" modified="2020-08-12" version="1">MPGTKEPVEFDCRPLTKDQRHELIELGQRMSDDMLTNALETQKTRVVALVRNDKTLRTASIHRGPDCIEPALIATCAHTIMQGTLDEVAEFFYLDSPAKFQAYICTVGETTMDRQNLYTLQCSAPRFYCGVSWFVFGCPWLVSNRDMCILEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X0P7</accession>
    <name>A0A6G0X0P7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_009696</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000122">
        <property type="protein sequence ID" value="KAF0733450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X0P7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012393"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
        <property type="entry name" value="FYVE_like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00136">
        <property type="entry name" value="PDZ_canonical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050776">
        <property type="entry name" value="Ank_Repeat/CDKN_Inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PDZ" evidence="9">
        <location>
            <begin position="43"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="476"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="548"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="583"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="10">
        <location>
            <begin position="645"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="134"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="361"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="146"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="210"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="361"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="394"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0733450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="760" mass="81817" checksum="058500F2A7F68B1A" modified="2020-08-12" version="1">MSGNWIDEQAAEYADLVNDSSFSSATGYVEDDPTEYQLIWEGGDLGVALTTNSSGAGVSVSRITGKGFPHGIKNVVPGDVLLAVNELDTVSLTLEDVVKYLQECDLPATLRLTRPENVTKNVEAKARQALLQTQRPSAYQAPRMSAMSSYKPQRQSFTPPTMANLPTEGVTSPTNAGKPMESRLSIQDRSSAMKKKGIASAYAPRVSTSAAPPQIQQQPAPAAVQAPKPQVVAAAPPKSAAAPPAMPPSILKKPSSVPKSTPPPPPQPVDNKLSIASNLSIDNRASAASNASNATAIAVEDVPQVVQPPVANREYRGESTVSDMAMMDSTEEDTAILDQDEDGGNGSFMEPKIMLVEEEAEDFANEEKESDDDDDDDNYAPLVIPNAPAPPVTSIPTKDNNAQPDAVKPYMPGMGSRDSTLGSSRGTKVLAAPAEPSQPMSTVHEAAAKGDLRGVLTHLRMDKNGPECLLRREPNHGQTPFHLAVKSGNVPLIQMMLDQFAAVASTEELLKIEDDKGNTALHFAATKTPHVVHLLLEAGSPVTSRNSRGLTPLIIAVMTNKKDDIIIVNMLLKFGANPNDVHDATTIIHTAISLKLLKVAGALVRAGAKLDVEDSEGKTVFEKLNRASIKYLVSHIYYPPTFINEKERSECMMCQKKFTFGRRKFNCTHCGRLCCADDASVFIPFVQFPQGFPGRIHKGHGVLDEKRCCKTCYNVLKERAAAAAPPKPEKGFVARVIGVEWDEVNPDKLQQIQSAGRRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X1F2</accession>
    <name>A0A6G0X1F2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Actin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_009541</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000121">
        <property type="protein sequence ID" value="KAF0733607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X1F2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019575"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13395">
        <property type="entry name" value="ASKHA_NBD_Arp4_ACTL6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000050">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0733607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="402" mass="43918" checksum="BE6C0832B948F48E" modified="2020-08-12" version="1">MYCGDEVGAFVGDVGSLNAKFGYAGEDTPNVVFPSCMGVRPATNERIVGQSALNSCHDITALPRAISTMEDKTNYNWDVMEKLWLHAFDELNVDPTQHAVLTCLSPFDMHESASYMELMFEKFNVPACYVAKDAMLNAFSFGKSTALVCDIGASSARVVPVVEGYCLKGSSSRSTVGGEALTAQLSSILLEKLKIDIQPGVRKYTDGASKPLTSVSSEYRNFRIMEIVRDMKESLCSMPETTLQEDLAESVAPETYELPDGQVVTLAAERFKVPEKLFHPDVIAADSTTVDSASKGLHRMVYNAVQSSDADVRKDLLYNMILCGGGSGLSGLTERLHWEVSQMVPSATYKVRLAQVSAIERKFSAWIGGSILASLGSFQQLWVSKREYDEHGAEAMAASRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X1M7</accession>
    <name>A0A6G0X1M7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_009323</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000119">
        <property type="protein sequence ID" value="KAF0733752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X1M7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000566"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052410">
        <property type="entry name" value="DRC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24107">
        <property type="entry name" value="YNEIN REGULATORY COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0733752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="470" mass="52920" checksum="81A83124581F143F" modified="2020-08-12" version="1">MKRPRRVAASITSIPAEIIQHIALFIPDTKGFFSFLASFQDAKRSEALGELSHFLKLAKILEGADLWPKLQLRLLRPLLIPTLRCVTRFFTTIYVLHVHNAGLIKRCLHDHNVVELLDSPSHSYLDQWLTESVSMLPVQHITFNSPSERSTALLVDQLDKMPHLVSLNLRRTNILLRDFDRLLAFIQARSTFSRLCLSTLHVPTQIQRRPNWIRGVEPLHRPPRLYRHQLDLLKEWLSRSRATSIKLRRWHVDDDGVASGVKLLHAIFASSTLESASLTTASLGPLIAMTKLRVPLRMQLLDLSDNLIDDTAMMSLAKGLRDSNIKSLNLGENNIGHCGMSALLDVLPTTKMQKLRLRCMYLDDSTCQAIAAVLPSTKIADLDLSDNNLTDRTAEALATAVGRATSLTSLHLYRNVISLHGASVLVNALSRRGQVTTWLDLGANFFHSNDKKYLHDMVHKSAQILKANFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X1T2</accession>
    <name>A0A6G0X1T2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_009349</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000119">
        <property type="protein sequence ID" value="KAF0733781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X1T2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009795"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031053">
        <property type="term" value="P:primary miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039727">
        <property type="entry name" value="SE/Ars2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021933">
        <property type="entry name" value="SERRATE/Ars2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13165">
        <property type="entry name" value="ARSENITE-RESISTANCE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13165:SF0">
        <property type="entry name" value="SERRATE RNA EFFECTOR MOLECULE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12066">
        <property type="entry name" value="SERRATE_Ars2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0733781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="634" mass="72861" checksum="5015CD964F05AF2A" modified="2020-08-12" version="1">MDAPEAIDQQAPPVETPASDAPNPYSQPPVNRSRSPYRGGRDRNRSRSRSPPRRRSRSPFRGRRRSNDRDERSRNGPPARVDNEPLESYKAFMMRQEDNVPPEVCLQRYEDYKKRVLVKSSRSFFDQHKMEEWLQERYSPAIRHRQLQQKNAKKRMEAKTFAERVKTVQISFDEAAWGSDTTQHPDYFNDMEESSRLLYIRRIPCSCPFSVLSEAISKHGSFQDLLLSDPLKKKDMEFERSAYILYETAAAASEAMPKLQNLLVEAPEIPHPLRLQVMIYRTRAPLKTPSYMSLPDRITYDYKQALHLATLLDKQSIEKNNINSILESLGEDKSERERLDIIVAYLRRVHHFIYYAGIQCFDMGDVMHAYPALFVRPAATERDIEDDKSVTHKTFSDDGTATAGAGWGAWSVSLDERVEAQIKLNEPSLVEAKNRAELELVQEIEGREESALEPVYKSYTEQAGDDGKHRCLLCTKLFKSLEFVKKHIRNKHPELVVEKIVSAGENYMWDQYREDPDRPMDPIVTVNQPVLRNSYDRRDSYGRGGGGGYRQPYYDGGRGGYRSGGRGGGYAPPNYPRRYDRPPPSRSDRPLPVDPRQISTSYQDLDSVPTQSVDLDFNDALGSLPPPKKIKKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X207</accession>
    <name>A0A6G0X207_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_009401</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000119">
        <property type="protein sequence ID" value="KAF0733839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X207"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009542"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="55"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="169"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0733839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="440" mass="48990" checksum="42D4CA69DB5629FD" modified="2020-08-12" version="1">MSVWQEDEEEEDLVALLNSTPEDAWCRCRSTTKLCARALHTNDPFLLAMLREEEENDNPVAANPSRQHLTTPPGPSAPSKRSDAFKLRVETTRVPSKATKELLASQSALIDQLRQKLHDKTAEAKMWKSKAKKRSACCDAKQSTIECAAVAPNTNSGSAPFSRPGKQMIDQLHDEIAQLKVRNQRLKDSNTQLRQRCKDLEAAAQRHMTASAIQAQTIEHLQLKLRGKAHSKPRGTAEPVRYVPKPLHHRENGATLTPLTTSSLDKKRLLLPRQAAPSVREGEGEASTPAMIVRSVREAAMHMGAVRELILRQSEDLLCRNLMCERVGDACMCRLSIVLEKLPNLTTLDVSANRLPALPPSVFQLGRLEELVLAKNQLGDDVFKDMHNFQRLRRVDLSNNQLTTVPSALAELPNLEMIDVRGNPLTAPLPKLPSRITMLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X2I2</accession>
    <name>A0A6G0X2I2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Myosin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_009168</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000118">
        <property type="protein sequence ID" value="KAF0733994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X2I2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004472"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012935"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00124">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF706">
        <property type="entry name" value="DILUTE CLASS UNCONVENTIONAL MYOSIN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0518">Myosin</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="10">
        <location>
            <begin position="81"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="9">
        <location>
            <begin position="990"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="6">
        <location>
            <begin position="637"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="883"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1104"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="841"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="911"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="174"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0733994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1161" mass="129973" checksum="C4DCEF55E51CB520" modified="2020-08-12" version="1">MGDDKSMATLVWVPHTKEVWKKAEIVQKVSDTSVEVRFVSDGVEYDPEEGQTKTYDVREIAKLAGEVSATAMPICNTFEKLGVEDMCTLNHLHEPAVLKNLQLRHAQFVPYTYTGQICIAVNPYKWLDLYRKELYPEYLNQPRNELPPHPFALSSSAYIDMNKNGIEQSILVSGESGAGKTETVKIMMNHLASISGGGDHGSLVIDQVLKSNPLLEAFGNAKTKRNDNSSRFGKFAQLQFNAEGLLVGARCETYLLEKSRVVGQAHGERNYHIFHQVFSLAEELKRELFIEGSVSDYAFVKVGAGSRVDNTDDSVFLQETKVAMDTIGIDAREQRGIFEIVSSILNLGEIVFKAETTEKCSVQSLNNVEAVAKLLQTKSEALQATLTHRTMAARGETFTIPLSADQAADLRDAFAKGIYSQLFDWLVTRINRAICSTRNVKHHIGLLDIFGFESFDHNGFEQLCINYANEKLQQKFNSDIFKTVQTEYVQEGIPLELVSFEDNQPILDLIEGRLGVIELLKETGVLAKGTDAMFVSKVVAAAADHKNFEKVRTNPMQFKIIHYAGEVTYDGDKFLEKNKDTLPVDLLELLASSESSFIRDVFPDLASPKSKNGKPSSRKGGGFLVGATIANSFKKQLGELMEQIAKTTTQYVRCIKPNANKSASEFDRQMVVDQLRCAGVIAAIRISRAAFPNRLSLVEFARRFEVICPSKLRNAPPAVMVQGLLEKLGITEASSQNSRFAIGKSKVYFSSGLLQYLEDQRSVVLRKQATLIQTHMRGYVKRKQFLAMKASAKLVQAVFRMHMRYKRFRVMKRGTVRLQSRVRGVMARRRFRVALAKERQRQLELKRAAEAKARADEARARDAKAKARAAELKAAQEAAYVDDSLKDDEPVETSSEGSEGDRLSAHSQSVLASASARVAEAEAAAVEAQKTAMAALTQNRIIQAENEALRAKMAAYVAEHADAELLRENERLKHQILTLQSKLVRAQEISLISAKVVESRLTFRDGRQFVEYKLQIETNSRGTLFVWHRYSTFRNLATTLQTKSGYRRKDIPDLPNKQLFGNFSEKIIQERIQKLNEFLEAATNTDYLQWGIRVDQDTCVYKRRTRSASGSDRESMAGPPRESMAVTMSDSSPRESIASRESFSIRQSLSRGFSFGKKASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X2W7</accession>
    <name>A0A6G0X2W7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_009104</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000117">
        <property type="protein sequence ID" value="KAF0734243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X2W7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015160"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051837">
        <property type="entry name" value="SortingNexin/PXDomain-PKLike"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22999">
        <property type="entry name" value="PX SERINE/THREONINE KINASE PXK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22999:SF23">
        <property type="entry name" value="SORTING NEXIN-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="4">
        <location>
            <begin position="227"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0734243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="349" mass="40295" checksum="AF1EFCA37C97F3A2" modified="2020-08-12" version="1">MPWLLELYPPSTDTTEYTLLLVFDILFIVIAAWWIAAIQPLPKTYLSEIIFPVQFWLRGAASMWLAIVTWVSYMYSSLWDPSHTLRFILVADSLAWTLSSSLIWMAHRRNLHLPLFVRSFWIVRWLLTLQHLVASLVERSPISKQEVPCIVFQSTLLVSVTILAVASVKPHRQLTPMSPEVVALTLERFPSFSSKSLIGRSMYGSFGASKMKCSLWLEPTSKEPNRIDLKVQIPSWTLSRKANASFVSYKILVLAPGESWTVRRRYSDFRHMRRGLPEALRQSQYFPEKSLFKSFDPRVIDSRRAKLEKYLNFIVAHPDVNPQSLLSLCDFLELEYVVNADDCQSYLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X3T4</accession>
    <name>A0A6G0X3T4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="5">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ae201684_008766</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the poly(A) polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="5"/>
    <dbReference type="EMBL" id="VJMJ01000111">
        <property type="protein sequence ID" value="KAF0734521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X3T4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010673"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000001">
        <property type="entry name" value="Putative poly(A) polymerase gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.590">
        <property type="entry name" value="Poly(A) polymerase predicted RNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011068">
        <property type="entry name" value="NuclTrfase_I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007012">
        <property type="entry name" value="PolA_pol_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048840">
        <property type="entry name" value="PolA_pol_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007010">
        <property type="entry name" value="PolA_pol_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682">
        <property type="entry name" value="POLY A POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682:SF10">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04928">
        <property type="entry name" value="PAP_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20750">
        <property type="entry name" value="PAP_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04926">
        <property type="entry name" value="PAP_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55003">
        <property type="entry name" value="PAP/Archaeal CCA-adding enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) polymerase nucleotidyltransferase" evidence="16">
        <location>
            <begin position="210"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase central" evidence="15">
        <location>
            <begin position="396"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase RNA-binding" evidence="14">
        <location>
            <begin position="548"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="99"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="123"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF20750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF0734521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="731" mass="80403" checksum="C1C51DA4A275F340" modified="2020-08-12" version="1">MKESQVVLSLQCKGKRPRELHLAILGDKDNASQPTVCSSSSCSSASTMPPRHLEDDSNDTCNVLQTHGRGTYKDALLCRSLEESVDTLPSTEIDNLSTASVASTLSPPDSPVEISDNQAPSPVFSPPLPPLPPSPPLPNDSQSRMSRHSKASAARIETSVLRGAIAHAAAQGVLSKSSKREMRQSMLRGQTNVILERLRRKCHLQPVVAPQTLPSPSEFELRLTNGLLKCINALAPLQDGDRLAAKHMALVEVNRTVDKWMQTMATTQSATGRRQHKALVFVGGSSYLKVDTGDSVMDLAVLCPHDVAPSDFFTDFRALLGETSVDEATFVPTLHCSLHDVHLALVFARYTQTIVPSHLPLHSDHILAGMDAHSVRALTVPRTASLVLELVPNPSTFRTVLRVVRLWAKMRGVDSAKMGFLRGVSWTVLVAFVCQMYPTATPALLVHHFFIVLSTWTWPMPIMLAKPYDAGHGFPQWSPSTDVHDRGHVMPILTPGYPAMNSATTVTLSTLRVLREEWTRGKLILDDMQLNALSSPVAWTTLFAPSDFTVRYDHYLHVRLTSVDDQPLARLASIVTTRLRKLVDTLQLTEHVLSVHPFPTLFQDDCATTMKTKSSEATQRRGGSFFVGFEVARNMSPTAIVAPVLKYFVATQLQLKTGVVTIDYASWQDLPDAIFPQGRDHAAGDRAKYMLSRAHKLHMAALHHNQQPPQPPLPPSLTPSVDFSLTCNNKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X4D0</accession>
    <name>A0A6G0X4D0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_008678</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000107">
        <property type="protein sequence ID" value="KAF0734720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X4D0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019021"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002259">
        <property type="entry name" value="Eqnu_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332:SF10">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01733">
        <property type="entry name" value="Nucleoside_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01130">
        <property type="entry name" value="DERENTRNSPRT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0734720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="429" mass="47229" checksum="EDC47436C59225D2" modified="2020-08-12" version="1">MPEVDDVVTLQTNKWSTEWPHLAISSATGRTMGSLFDISPSLERHLINVLFSLIGVGYLFPFSALTQPVDYWTFLFPDFNIEFSITCVFLYTNLIALALIVSFGSTPWFTGRIVGGFAGQLGVLVFVPAVYYYISGESAHIASVLGATAFAAIVTAFLDSCVISLASKYPLHAQESLQFGIGLSTLIGSIYRDVTKLVFPPDAVIASSSLYFYTGAVTVGLCIGAYFVLLQVPMSKKIATATSEEKLPLVEAKTTELNRWTILRKCIRNQIQVALLFMTSLTLWPPLVTEMKSYNFPELQKTGWWPLILLTIFSVVDCLGRLLVSYRCGLTKDNVWKAVALRMLLVPCIVLSVQGIWFTHDAWSILFVVILGFTNGYHGSLTILFVNECVDDNEKHIAGSFTGFFLNFGLVVGSTLGLILSQFVHAPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X4E9</accession>
    <name>A0A6G0X4E9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_008674</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000107">
        <property type="protein sequence ID" value="KAF0734716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X4E9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019017"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054585">
        <property type="entry name" value="NDH2-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706:SF13">
        <property type="entry name" value="NADH DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22366">
        <property type="entry name" value="NDH2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="6">
        <location>
            <begin position="35"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="External alternative NADH-ubiquinone oxidoreductase-like C-terminal" evidence="7">
        <location>
            <begin position="400"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0734716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="473" mass="53055" checksum="51B19555CC5DC386" modified="2020-08-12" version="1">MLLRQSTRCLPRFVPLLAGRSRLAHNVAADAGDRFRVVIVGTGWAGYKLLIKGKDYRQEIEQAMGKPVDFVVVSERNHFLYTPLLASTTVGTLEFRSITEPVRETVFRHEQDFILASVKAIDTEKKQLQCKSSLSNRDYKVNYDMLVVACGSRPLTFGLPGVEEHAFFLKEIHHARAIRRRIVENFELATQPGVPEDVQRQLLHFVVVGGGPTGVEFCAELYDFVVEDLTRFYPQVSNLLRVSLVDAGEILSTFDATLRDQAMRNIKKRDSMNIIKNNCKEVLADAVVLQSGEKIPCGLVVWTAGVGPNELTKSLPWAKSKRGNILTNQFCQVLGLPSSEKDAKPFLGLQNSSSVFAIGDCAEIENYPLPATAQKAQGQALYLLDLLLKRPIEPYRFDSKGLMAYIGSYEGLFQAKDVHIGNKSTPLAKFGGWQAWFVWRSAYLTKLGSWRLRLQVPIDWIKAMVVGRDVSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X691</accession>
    <name>A0A6G0X691_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_007998</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000095">
        <property type="protein sequence ID" value="KAF0735518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X691"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002198"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0735518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="709" mass="79160" checksum="A7940B4C0C69CB46" modified="2020-08-12" version="1">MRRPTWKLTINLALVGLQYTALRRRLRTHLRRVPMNKDDYFLHYREELKDKPSTSTSPFSMHLTSGLGSVDTTVTSFGASIFAGVYNLGSKWKMNIQDSKPSNPVDEATLLQQLWARQLYLDACFRPVVVAKLRLLAVQQNRKRDEAQNIRSQTYNKATGVLTVTIVQAHLNLSRINKWPLPSELLLSVKLKVGAQGVEYVGKPEPCSPPLASTCCTCVGLPDTSDGVCTFGQTYEFHLRGTPDEDYLYITIQDRWAFPYLQQFSTKAKLFLAACTIAPQSNNDVAFDEAKGHLRVLTNFSKHSCECSTAPSTSESMYRSLFPQLYELKHSYISWFNPDASTGEKQNSTTLTLSQLSLESTVVLHIQFGPAIASSMHIQLVHLAVVFEKSLDIKQSPIIRGTVDAVIVYRDQTSQPCVVSTGVTPAIEFKTTDSPRSISNQIQVGSMNITLSIPGLVQYYTSVLRWKNQVLDLLALLYAPIYGPFGIWIAPPQDPNPSSICGPTAITTTIHSAGQTIFLDELGTWILPTAVIEMVTKNNASTISIGDTKVASLYWNAWESFRRHLDAAMTAEDITESSMTLTETPKPVLILLTQGIVVLKHHTNRGKPQERVLWLHRASLMLGKSRYDPAPFQMPLREIQRVSTGNSSAALRRSGTLENASLYLTLENPRRSISLEFIHTTIRHEIQTLIHSLMTEPAQQDFPLTLSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X6B1</accession>
    <name>A0A6G0X6B1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_008018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000095">
        <property type="protein sequence ID" value="KAF0735538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X6B1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014927"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF37">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="288"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0735538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="578" mass="65486" checksum="27666076B0E1F33C" modified="2020-08-12" version="1">MADCLDGATQLSKKVANRIARIRYQERKKIRRTISRALAEGDEENEERYVNINSALNGLYCPDTGADVDIIPKSILDDLLVKCPDLEVVQLGEPLKGLGCNDQGFESKAYVELDLTMQTSAGAVRVPGRRKCYVVEEGDELLVSDQTLRLVGINIDRLLTAQRMANEDDDLEEIDLEPPRLRRRYVVYMRTARLGLPKPKTELETALAAMVQEACDEGFPGDLVGRLWSALTKHDIWRLKFNGSDPPAKVEPLRVTPKEACEPYRCKGRLHNPLETRFLTLFGKELLDAGVIRHNQQSQWCSPVNPVIKPEGRRMLKAADKWTDDEVLKYYRLTNDYRVNSKTIPKAGTMPFQSTITQHLRGKKALGTFDMPKCFWQFPLDPASQDMLSFMLNGWVMTPNRVMQGHVDSALYVQSTCEDCYAPLLNKHLLVWIDDILVYADDPVEYVKVLVRFFDLVNEHGFKLSPTKTKLYTKEVKWCGRYLSDTGVKQDPDRIEALCAIPEPTNAGDLQHFICATKWLRESITEHAQTVEPLQRCLTRALEGKSKKKRIASGIQIQLTDAEKQAFAAVKKLASSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X6L4</accession>
    <name>A0A6G0X6L4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="10">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_007997</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the E3 ubiquitin-protein ligase UBR1-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="10"/>
    <dbReference type="EMBL" id="VJMJ01000095">
        <property type="protein sequence ID" value="KAF0735516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002197"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071596">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the N-end rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd19673">
        <property type="entry name" value="UBR-box_UBR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.30:FF:000002">
        <property type="entry name" value="Putative e3 ubiquitin-protein ligase ubr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044046">
        <property type="entry name" value="E3_ligase_UBR-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039164">
        <property type="entry name" value="UBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055194">
        <property type="entry name" value="UBR1-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497:SF24">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497">
        <property type="entry name" value="UBIQUITIN LIGASE E3 ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18995">
        <property type="entry name" value="PRT6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22960">
        <property type="entry name" value="WHD_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="12">
        <location>
            <begin position="30"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="9">
        <location>
            <begin position="30"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="774"/>
            <end position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0735516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1593" mass="178945" checksum="B4791EFF57AE0822" modified="2020-08-12" version="1">MAQPTPQTYPWVAAIREAVDANPNAIRRKRMCGYEFRPGDMAWNCRQCQKDETCVLCHACFSSSHADLHHDVTFYYTQQGTGCCDCGDEEAWDPAGFCAQHNPPTEATGDILSSVPSDLLDVAHQDVLQDVDILFKYALARRRGFRREISKEDTGLFDLWLHVTEANIRSAQEKLTLVQSRISAESVFHWLSTLDKSNVSLFDAGDADVYANVLAVFARLTHAALACDVGCRLVAHHMSMKPDFLGHLIRVETLLPQPEGTAMHTLIMALLPDPAFKEAFAIAYTESYAFIFEEYLHGLGTQGQTILIFGVQFLNRASFVYKLMSCHGLLEVLLGALEKALLEGSIPITLPEQITTTDTIMSSHPWDILAERMLQPWTQSDLEEQVPPLVAIRIDAQQFTSHRYIQVLLDLKYVFQIPHNGFLDNYATHYRWLCRILALLQGIGAAARLQPTEPHVALESRSWIVCIELASMVEELVSALIANVVTSKHDHSSFDIILKLVQPLVDTYCTWLAISRMYFPTELQTVGAKDMPVGAHFPLHQSLFLILRACTSSPDAMNDFDVVLNQVLPHPSSEPLGAWHREMLARPMMRSLVWDAQVHIGMWKRNGWGVVNHSMNYGEPYYCMRFRDLDLLGLQYSVAMLGMDTFISRLLLEFDGASLEVPEYDEPMMAEFLKVICQLATELPLADGGSLNTPLRRVLLLRLCSKPSTHSELFKAVSEFCSVHEVHAVLNPIAYDAAVKELTKDWIMPNQKNYTLDPKHLELYDATTIHLTRKQHEAARLNRLEYRMEQFKKNSNNAAQDRTYLPAVPPPLHLSNGLLGQFEPAFYLVLHPALTPALEGIVRHMDEVPLTLSTMAVHLLTLQLYALRTALDHPVYHELGNQFLEWLPSIVPTLEELNPWTKDVPSRDTTDHERGRHIQWILHELSSYPRFHSIAYAPALASFPPSSTGSQTDSLRHRAQQMALLKMQQQQAAFSDYLDETISDDESDSQNVCAMCLAKEAGDESALCYVGFVHPSSLNVPSGHVKKTPWEDMKKEVSLTMQCCGHCVHASCWESYYAAQFQRVITGEAYLNAVDVKKGEFLCPLCKAISNVLVPIMNEPAPPLAPPNALDDFSWEQWLFAPSPPSTDALSSPLSEGLAKLCMSIHRVATGAIEKAYPERYITTACHAVFTTRWTTALTDISKDRIQPFVAAARHLRHPWLTWQLRMLLKLGHTSDERSAILDTHTLTQVQKTWISVVGMKPLLIHDLGSIVARGILLSDNYVDAACIVQLVALAFIVQTTLWLASAPTLSVPVDEAATEWFLQSWCGGVTKAQAAGSLLQILEGSIAWPENEWERLVDLVAMEVFPFCREAQTMIAQYEITWLILPELPPTLKQLIHTWICAFQNTYETMQDPQEVLAQWRLKQNILSWSPVLHQDLDTSHVPLSVIWFHHRTQYLRQLPASYNSLYLQLTKQVCPSCQLFPARPALCLICGSLLCAASSCKAITPVSVSGACTLHAHKCGRGVGLFLLVLEGTVLLVSGKLASFYGHGLYVDEYGEGFGENHSVATYRGRPLFLQTQTRDQLLRLWIQQGIPMEIVQSQNIATHIVPNSHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X7B0</accession>
    <name>A0A6G0X7B0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Crinkler effector protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_007889</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Host cell</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000093">
        <property type="protein sequence ID" value="KAF0735887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X7B0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003771"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043657">
        <property type="term" value="C:host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045379">
        <property type="entry name" value="Crinkler_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20147">
        <property type="entry name" value="Crinkler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Crinkler effector protein N-terminal" evidence="5">
        <location>
            <begin position="5"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0735887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="440" mass="49534" checksum="20AB61EE67F5B745" modified="2020-08-12" version="1">MGGGLSLRCVVVGEGRPFTVKIDSNEKVDKLVKKIKEEHKNTILRDAKELKLYCVDGLVQKSPTQFDLKGTEIDDLSVKLLGDFDGATTEMVAIYPLSEYPQLKDSSTGRIHVFVLPEGPVVSETSAPTQMVQRKRKRYQHSKMDPTNGMNLLRALHIHVEVAEALPFATRDPTPVQPFKWTSVDEERGLEMKLTEEQQRQRYQSYLEDNIGPVLAEKELCVLGVEKDNDILSVAVPGFKIDLVGRTDILVLSDIVKTQPDILQFLPGVRLLIEVKKKGASDSVYQALSELIALDFLTRDPVMALLTDLNGHWKFLWVSEKRNNSIRIEACIIKTPSEAFEVIRTLLAQSPTSHEDIQLPCCEGPVKRRKLTNMLPSFNEGGEGNDILERIQRMRDVASELGPDIEMVREIARQFTGFFIPCFSVRKDHAGKVLPDEDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X7F6</accession>
    <name>A0A6G0X7F6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Calcium-binding protein 39</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_007566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mo25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000090">
        <property type="protein sequence ID" value="KAF0735972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X7F6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020586"/>
    <dbReference type="OrthoDB" id="609103at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000257">
        <property type="entry name" value="Conidiophore development protein hymA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013878">
        <property type="entry name" value="Mo25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10182">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10182:SF3">
        <property type="entry name" value="PROTEIN MO25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08569">
        <property type="entry name" value="Mo25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0735972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="39974" checksum="E06A38560664AC42" modified="2020-08-12" version="1">MDLFKAKKNPEKLAKQLKEALENPNAPVKPDKSGKVVDIVTKRLHQIKVMLYGEVGEEESSPQKCAQLSTLLIADNVMPRMVLNLATMPFEARKHVAQIYNNFMRRDLGGFVAYIERQPQIISALVRGYENSDIALNCGTMLRESIRHESLARQVLYSDDLWKFFDNYVHLPNFDVSSDAFATFKDLLTRHKTLVSAFFESHFDVVFDKYNKLLSSENYVTRRQSLKLLGEILLDRSNFDVMMRYICKRENLKMMMNLLRDTSANIQFEAFHVFKVFVANPKKPNDITQILLNNKDKLIAYLEKFQNEKEEEQFVEEKALLIRTLRTLELRNEDDVASAQTASTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X8L5</accession>
    <name>A0A6G0X8L5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_007246</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X8L5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001958"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43102:SF2">
        <property type="entry name" value="GAF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43102">
        <property type="entry name" value="SLR1143 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="45"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="603"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0736224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="638" mass="71347" checksum="73D468D030A0D398" modified="2020-08-12" version="1">MGRSSSGGCGGDESSFLEKAPHVYYIESGFLAVGNLLRPEQWVKDENRRHCNICMQQFHAFRRRHHCRTCGEVLCNSCSKHKKIRLVELNFDLTVRICTFCIIQATDATRDCRRRSKSSAYRDKDVMQTPILGTNDAQDIPDSVIDDKESNLTWRLTSQKSTCPPWPAPDESAVMSKLDDERQADTFSEDNTLNVLVHLVANSLYANMVCICLSSSPTSEASFQASVGLHSLHASPADLCELVWREGRTCILHDTQADPKCPPTLLMHGIRYYAATPVRVSGAVVGAVVAMDIVSHNQTSLAQRNTLESVARIAAEVVEERTRVNNPEVLSSAEDEEDDVVGNLESMPCIPDTMLTASARSNLMLLAVSRQSVTAYDHGIQSAMMFYRALLRSAWELEEEDEYGARLFSFEERYGRGYLKATKVIAIDGKVDWNKVLDLRQNKVYGDVVLSVTGRKMINLHTTLDHVCFRGKTLWRSTKETRLLCHRRQYPGGAWTMIAIDATDMEFCLAWLISPHAVDHVLVTLIVPHVVGQRALLFDLLSRVQEVTENMGDMRLSACSGSADILETRAVRAYSCSVLPQESSGSGFWDLLGKTILTQQLLSQQQNSMLETLEENAAKLEELSHAVDRVETLLDRHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XA16</accession>
    <name>A0A6G0XA16_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase Tc1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_006961</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000087">
        <property type="protein sequence ID" value="KAF0736804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XA16"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016452"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169:SF2">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0736804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="33732" checksum="F50E60B19F3A78AA" modified="2020-08-12" version="1">MKLKPGAIRDVAAKFGVTAKTISRIWRRADIDVNCGRVLCSDVSSRRTGSVGRKLKWLDVAGRIKKISFNHRTCLRKTAKALQMPYTTLQRYFKRGVVVKYSSNVKPKLTEANKLARVKWALDHVRYRGGLNFDDMMDVVHIDEKWFFMTKLKTNYYLAPDEEPPHRTERSKQHITKVMFMAAVARPRWDEATRTWFDGKIGVWPFVIEVPAARSSRNRPAGTLELQTIPVNKETYKDMLLSKVIPAIKEKWPLRSTRNVVIQQDNARPHVAAFDDDVSAACTDGEWNMIVRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XBS5</accession>
    <name>A0A6G0XBS5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_006625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XBS5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006176"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="332"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0737464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="387" mass="39853" checksum="9940535168DE60FF" modified="2020-08-12" version="1">MSSKRGVAPAATATYAVVAAGLVGLAGFLALKYFDSKPDKQPASRSIKPKNTKLSPKAAAAVIENAFVAHKDNEKSSPKAKPPPSPRANATPSPPPSPKQAASTIESAYLAHKSSSTNASPVASPAKKPATPVASPKQTTPVSSPRARNDSLKEAEAAVVIENAYIAHKASSSPVPSPKTSPKAKTPSQDQVEAASVIENAYIAHKSSPKASPKKTTPVPSPKASPKKPITPVASPKASPKKPTPVSSPVKAVEEEKVAPTEAATVVAAPPSPKYSTPPSSPKKSPASSPKITRKGSLPPPQDATEVEVEAAHVIENAYVAHKSSPKKAEVESSLESSVTSDGFVELKASTEETVAADDDDNSSVPAASPTTDQAKNKKKKKKKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XBU9</accession>
    <name>A0A6G0XBU9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Extradiol ring-cleavage dioxygenase class III enzyme subunit B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_006653</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XBU9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011417"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07363">
        <property type="entry name" value="45_DOPA_Dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014436">
        <property type="entry name" value="Extradiol_dOase_DODA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096:SF0">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006157">
        <property type="entry name" value="Doxgns_DODA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53213">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Extradiol ring-cleavage dioxygenase class III enzyme subunit B" evidence="6">
        <location>
            <begin position="12"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0737493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="278" mass="30213" checksum="055C5879E657B868" modified="2020-08-12" version="1">MADVATDRVAPAIFISHGAGPMPLLNPASDPNHGPTRTFFEQVAPQWLGLHDPATKPAAIVLVTAHWEENVVNISSGTSHELYFDYYGFPRPAYSVRYDAPGSPELAEKIKLLLTEANIEAQLNPKRGWDHGVFVPMKLIHPSADVPIVQVSLARSLDPQLHFRIGQALAQLRQDNIAIVGSGMSFHGGRGSSQVKNHSKNFLLALSGACSKTSVEERGEALKGWASMPYARECHPREEHLIPLHVVAGAAGEGRVKTHDIKSASSEITIRCFGWGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XC36</accession>
    <name>A0A6G0XC36_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_006729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XC36"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0737574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="140" mass="16464" checksum="EF8406606D799B9A" modified="2020-08-12" version="1">MTNKSTKTAQKQWFRRAGDFSDDSSNDNSVSLTQDILRFQAAYKSAKPTRRQYTIKERQRILSELLKRPKEIRAISRDENIPLETLYTWTKKRQEIMTAETSEKKRILKNPAKNSAKRHPRLGTKLPMREDPELIDELKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XD56</accession>
    <name>A0A6G0XD56_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_006084</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0738095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XD56"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004074"/>
    <dbReference type="OrthoDB" id="605656at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08069">
        <property type="entry name" value="MPN_RPN11_CSN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000001">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056263">
        <property type="entry name" value="RPN11_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23594">
        <property type="entry name" value="RPN11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="7">
        <location>
            <begin position="34"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0738095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="312" mass="34671" checksum="8EFE7975C2702F51" modified="2020-08-12" version="1">MDRLQRLFGNLPGMQGHGMGGANDGPAVDTAEKVHISSLALLKMLKHGRAGVPMEVMGLMLGEFVDDYTVVCLDVFAMPQSGTGVSVEAVDPVFQTKMLDMLKQTGRAEMVVGWYHSHPGFGCWLSGVDINTQQSFEALNARAVSIVVDPIQSVKGKVVIDAFRLINPQLMMLGQEPRQTTSNIGHLNKPSIQALIHGLNRHYYSIAIDYRKNELEEQMLMNLHKNTWSDGLVLTEFEAHSAKNEEIVESMLKLTKQYNERVQEEEEKTADELIVSNVGKVDPKKHLESDVYDLMALNTVQCLGAMLDTIVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XDF7</accession>
    <name>A0A6G0XDF7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PhzF family phenazine biosynthesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_006172</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0738196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XDF7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011741"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003719">
        <property type="entry name" value="Phenazine_PhzF-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00654">
        <property type="entry name" value="PhzF_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774:SF39">
        <property type="entry name" value="BIOSYNTHESIS PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774">
        <property type="entry name" value="PHENAZINE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02567">
        <property type="entry name" value="PhzC-PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016184">
        <property type="entry name" value="PhzC_PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR016184-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0738196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="29573" checksum="010AA12667AE9B1F" modified="2020-08-12" version="1">MSVQKIAAFSNGNLGGNPAGVLIASSLPSDAEMARIAAEVGFSETVFATPLSEDKHYRVRYFSPESEVPFCGHATIALGAALALANGNGVFDLQLNEAKITVQGTKTEDGLVAAALQSPPTHSHAASEELIHAALALFGITSEDLDSSLPPAIVHGGANHLLLAFKKRETLAAMHYDLEAGRKLMLANGLVTILLVFAETPHLFHTRNPFASGGVYEDPATGAATAALAGYLRDISWPHGGAINIVQGEDMGVPSRLHADISDERGSSIRVSGTARIMNENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XFS9</accession>
    <name>A0A6G0XFS9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="2">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_005278</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="2"/>
    <dbReference type="EMBL" id="VJMJ01000067">
        <property type="protein sequence ID" value="KAF0739098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XFS9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015997"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05168">
        <property type="entry name" value="PI4Kc_III_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000016">
        <property type="entry name" value="PIK1p Phosphatidylinositol 4-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057754">
        <property type="entry name" value="PI4-kinase_beta/PIK1_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF22">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="7">
        <location>
            <begin position="649"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="473"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="584"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="588"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0739098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="932" mass="106515" checksum="F2B06C12A7E47C6B" modified="2020-08-12" version="1">MYFSSAAGLFLEFVVFALYVGGPVVGRREEIFKLDWANALDFRQSIACVIWLAVLRALLFVYVICVTKNSLYKTTRCFVFLIVCSEMCVLTVLALITYIHQNDDVSFLLYRSDAWVQGYWWSVIVSSMIATTFQAFCVICRNREREIPGNHEEEHIQMLLEEKKGIYDANDPLLSTKRKKLKRWRDKWEKLVSAFRNKTDPTFNAVLRIYAHKDDAALRLENLYDADPKEFEFYIPQLCSFLLLGAFQQSSEGTLSLILLRVCKESHVFAQKMRWYLESYCVGSPAYSSEESRMRVQMLIDEITIRGQEPSKKLLTHQGIGEKAPSEDACRVDEEELLLKDKDTHYRTFASIKEIGATNPFTWNHRFVADLVGLSSNLRHIPRDRDQRNMHLRQVLTDIQTTYLPSLSLFLPVGNPFHRIKKIHINECFTFSTRERVPYLLCLEVVDFFTYEKKPMDRFAQLKNRFRLSIAGKSESSKPSTPVVQPSDLEAGGPAPKVNNSSDPDNLGFWSEPKVQETSILDGFLGSLKPKVLTPLPQRQLNSKEEPLQPQSPIQIGASSFDYPYPPHLSPKNLRPLPIHITEDPLVSPTNSETLSPHSPTEGRLRRVDSTDAFLASSRFDDDQTDHPVPAGVASSSDLPCVVFKERWVDKEARLRATSPWGHLPSWRLLPVIVKSNDDLRQEQFASQLIRQFANVFEDAKLPVFLRPYDVLATSPTAGLVEAIADTISLDSLKKNDPDFVSLQEFYTRRFGDPSTSSGQAARKAFVESMAAYSIVCYLLQIKDRHNGNILLDADGHLIHIDFGFILSNSPGNAAFESAPFKLTADFVEVMGGPRSAAFRRFRSLCVRSFLVARKYRYRITLLVEMMVAGNEDLPCFQGDPRGTVDRLAERFRPDLSVPECEDFVHQLIDASLDNWRTRWYDKYQRWFVGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XHJ4</accession>
    <name>A0A6G0XHJ4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_004864</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000063">
        <property type="protein sequence ID" value="KAF0739696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XHJ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018158"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018159"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13999">
        <property type="entry name" value="STKc_MAP3K-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF214">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="357"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0739696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="690" mass="78163" checksum="ABF9EAE5BF31F6E1" modified="2020-08-12" version="1">MAKERQVIPSSSDHGADRYKSFLESTAKDETQPEHKERAFKRMMSQPKLVEMTSKWTNQYDSQATEAAFQSWSCAFYVVSAKMLMSCVIFFHVLLAAIDYSFSPSTGAYLAKYGYTELAQWMYLVVLCPLLVVRSSWTIYKRCLWYFHHWKWVVVLSMVFVCTGLMIRTGCVYDVNLHKWQTNLDTTLKSLNVSITLEAKNAIAATFNDAIVAIAGNLVVAGDTILILITQIIVSASHCDLKHSMVAWTALLISLACNIVYWNVLPHNEAFIYLVVSGIQCYLITRELDLSHRINFLNYYQAETSAQVLRDQLDQALELIVYNDCKAEEKAAVTTAIDDDAQLCAKLEPYRIPFENLKLERVIGQGAYGQVILAQFCGTAVVLKRMHRHKITNAAMKQFTDEILLMSDLRHPNIVQFIGASWDTYANIGFVLEYVGQGDLYMVIHDKRIPKSWVDPFHRIAVDAARGMCYLHSKNIVHRDLKSSNILVSPTYAAKICDLGMSKSIDELKQLDQQVGTPLWTAPEVVTGGRCSFRSDVYAFGIILTELITRKTPYEDQTPGMSAYKIMLEVATNGLRPTLPSWLPDQLRRLVDTCLDANPSNRPTMLEVLDTLQIDAIVQLQGHELWKRARQLVHEKAHRSTQFSVELVRLAKAQSELEACSRPRALDTDLTFDSVQAMTSVLDTTIVEEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XHP1</accession>
    <name>A0A6G0XHP1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_004882</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the free Met sulfoxide reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000063">
        <property type="protein sequence ID" value="KAF0739714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XHP1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018177"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033745">
        <property type="term" value="F:L-methionine-(R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051330">
        <property type="entry name" value="Phosphatase_reg/MetRdx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021:SF15">
        <property type="entry name" value="FREE METHIONINE-R-SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021">
        <property type="entry name" value="GAF/PUTATIVE CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="2">
        <location>
            <begin position="172"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0739714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="299" mass="33279" checksum="3285AAB5483465B0" modified="2020-08-12" version="1">MSTYVPWTSVEETIQKEATKVVYVYFDTPSDADKTEKIASKLGEILGPHRTDLIQTRVDASQLDTNQLANLGVTQVPFIQLYYQGKLKVGLDASHAFIDRLLLPQIGWYAGDKSHEKEDALTPVDYVKLTEEIERRTLAESDFLANCSNVSAAIWDAFKQADRPVNWAGFYLNRPIEGTEKRLLILGPFQGKPACTRIEFHRGVCGACASTRRIQRVPVVKNFPGHIACDDASQSEIVLPIIVNGELIGLLDMDCPNEYGFTIADAAGLQGIVDLFAARTHWESFSLSVRTAPIEEHDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XIG9</accession>
    <name>A0A6G0XIG9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">THH1/TOM1/TOM3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_004555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000057">
        <property type="protein sequence ID" value="KAF0739896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XIG9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006406"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0739896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="365" mass="41426" checksum="223C678A0C40EA30" modified="2020-08-12" version="1">MTAGECYVKGSQKTICCYGIIMKHNLCITSDANTFASLHRTANKVYRISCLVMGLLAFLACARKLYIIHRTRGSFIQRWSFRLLMVASLTFVARSPDPQSYEFIYSPVVSGLFSDICSACIYSVIVLYGAFYARLVVNPADLTISEHYIRGFMGLALFLSWFVFVVVRPAYLLHDPRNIYYSWHILMQFSMAPLLLFVLSTTALYFGLLIYRRLLWIRRVNDRAAEIALIRRAAAKPQSDMAVQNSISSEVDIAMLDKTPKSSNSRLLMVVIAVELISIVVMALHIWHLVQFVRDGCKLHAEFLCATDTNGDCTSKSFPFQVPYMCIVQYCSIILFYWSFHRTKHEAVESSNASITPQSRSLGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XIH3</accession>
    <name>A0A6G0XIH3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Origin recognition complex subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_004527</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000056">
        <property type="protein sequence ID" value="KAF0739945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XIH3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013264"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11583">
        <property type="entry name" value="Orc6_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054113">
        <property type="entry name" value="ORC6_cyclin-like_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008721">
        <property type="entry name" value="ORC6_cyclin_first"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020529">
        <property type="entry name" value="ORC6_met/pln"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13394">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13394:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05460">
        <property type="entry name" value="ORC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21913">
        <property type="entry name" value="ORC6_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ORC6 first cyclin-like" evidence="7">
        <location>
            <begin position="4"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="ORC6 second cyclin-like" evidence="8">
        <location>
            <begin position="96"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="198"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0739945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="32396" checksum="282C859ABBCD0508" modified="2020-08-12" version="1">MDIQALAEKHGGMSASVVSKAQEYARMLDVKLQGGGSLVPVLQRPAACLELACELLQEPFDSKKLCKFSGGTSVAKHKQCVRSISSILRVQAATTITTSSLCIKFGCPTLKDFVAAVQDEYKQRMMAKLTLNQQRNVDMTRPLFPAAVFYACAQKAHLRVDKNSLIQLTRCQPKEFASVVTSIETLCKQTLSNFIPVESTTQKKRKRKDEAPPEKDDASNEPTTKPVVSSSSNTRSLEQIKKLIEHRSVNQLQPRAAVKPTPEPSSDPAPAHATHDEYVDWKKKILAQMKDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XIJ7</accession>
    <name>A0A6G0XIJ7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_004403</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000054">
        <property type="protein sequence ID" value="KAF0740169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XIJ7"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0740169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="66" mass="7855" checksum="5012F7445C50DF3C" modified="2020-08-12" version="1">MFAVKKKVQVDKSKQRRALMWEIVRLEESTRRRLVIDHRVKILIVQDHDCKLDARVFALILALKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJF7</accession>
    <name>A0A6G0XJF7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cellulase</fullName>
            <ecNumber evidence="3">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ae201684_004043</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 7 (cellulase C) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000051">
        <property type="protein sequence ID" value="KAF0740496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJF7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010906"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010907"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.100.10">
        <property type="entry name" value="Glycoside hydrolase, family 7, domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001722">
        <property type="entry name" value="Glyco_hydro_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037019">
        <property type="entry name" value="Glyco_hydro_7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753">
        <property type="entry name" value="1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753:SF1">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE CELB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00840">
        <property type="entry name" value="Glyco_hydro_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00734">
        <property type="entry name" value="GLHYDRLASE7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026306632" description="cellulase" evidence="13">
        <location>
            <begin position="21"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="14">
        <location>
            <begin position="467"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="361"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="411"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="429"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF0740496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="505" mass="53014" checksum="CCE5C47F3F1FBC3A" modified="2020-08-12" version="1">MKVSTTIAYLTSALVAQTHAQQIGSSTTEVHPVLQTQTCTKSGGCVTQNTKIVLDSNWRWLHQVGNFSPCRNDAGVWNTAVCADGVSCAKNCALENIDYGATGIRTTGGSLNFDLNKRLYLLEDDNNYKLYKLLNLEFTFDIDLSKAACNVDAGLYFIEMDKTGDRSATNPAGATYGTGYCDAQCGEGAPFIHGKANLNGNIGTCCAEFDILEANSISTSFTSHPCTKTGLFECTSPLECGGGDNRYKGTCDKDGCGVNPWAMNVHSFYGPGSSFTLDSSKPYTVVTQFITDDKMLPATLLKSSVTTQPGSSITDSFCDQVKYVFNSVNDHKAKGGLVAMGKALQRGLVLSFTSWTGDLPWLDGTNPGSDPTKPGGSQGSCPPNSPIPTVAPITVSNIRVGDIGSTTATSPPNPPVTLAPTTKAPPTPATSSPTTVPTTTRATSAPITTRATSAPTSAPTTAKPSSGAVVAWGQCGGSNYNGPTGCVSGYTCHLYSEWFSQCIPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJI9</accession>
    <name>A0A6G0XJI9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_004192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sel-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000052">
        <property type="protein sequence ID" value="KAF0740458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJI9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010464"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050767">
        <property type="entry name" value="Sel1_AlgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102:SF160">
        <property type="entry name" value="ERAD-ASSOCIATED E3 UBIQUITIN-PROTEIN LIGASE COMPONENT HRD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102">
        <property type="entry name" value="SEL-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0740458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="278" mass="30424" checksum="1D6FB36ED4CE4FB3" modified="2020-08-12" version="1">MLLSRRFLTRRFSAAASGNNEYLEGIKFLQKQDVQSAVARWQSAADLGHVKASSALGHLFLMGKDNVEQNYALAAQYLKRAADEGHANCCHQLGRMHLHGLHFEVNGAQALQWWQRAADQGHSAAQYDLGYLYDKGVHVAQDKTKAFELYSHAAKQGMPEALRAVAKAYLQGDGVEADHAKAFKMFTKAADAGNVQARFNIGACYALGRGVEVDHAKAAASFFLAAEGGVPEAQLCLAQLYESGRGVDKDMKKAKEYYEAAAKNGLNEAKARLDTWKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJX1</accession>
    <name>A0A6G0XJX1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">Ae201684_004064</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DDX41 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="VJMJ01000051">
        <property type="protein sequence ID" value="KAF0740518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJX1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005994"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000449">
        <property type="entry name" value="Probable ATP-dependent RNA helicase DDX41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000657">
        <property type="entry name" value="Probable ATP-dependent RNA helicase DDX41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="18">
        <location>
            <begin position="172"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="203"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="399"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="15">
        <location>
            <begin position="575"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="13">
        <location>
            <begin position="172"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF0740518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="619" mass="69966" checksum="37FEEAAED98F5E83" modified="2020-08-12" version="1">MSDKEDEVYVPLKQRRQEEEERRRKRQKIIQEKLKQVTGEDEEDEDEQVSRKPRQDPEPPVIFDDVAPVRSTVSLLDQSFQLKKKRENEGVDEEERLQTTSEVQLLHEASHVQKASLVSAAERASGIRYTESMKTTWTPPRHIARMTEEECDQVRKKWHILVDGDDIPPPIKSFAEMRFPPPILSALKEKNIVRPTPIQVQAIPCILSGRDIIGIAFTGSGKTMTFTLPLIMMALEQEKKMPFIAREGPFGVILGPSRELMRQTHEIVQHFFKALYKAGFPELRSTLAIGGQDRRDQLDLFMKRGLHVVVATPGRLKDFLMLKKMTLDLCQYICLDEGDRLLDLGFDDEVAAIFNHFKYQRQTLLFSATMPQKFQDFAKQVLVRPVLVNVGRAGAANLDVLQEVEYVKQEAKIVYLLECLQKTAPPVLIFCERKGDVDDIHEYLLLKGVEAVSIHGGKDQEERNDAIDQFRRGRKDVLVATDIAAKGLDFPDIQHVINFDMPIEIENYVHRIGRTGRCGKTGVATTFINKNVPESALLDLKHLLVEAKQRVPPVLKALEDPMEHSQDNSTGSKGCAFCGALGHRITDCPKLDTQARKLNAGRRDYLGGQSGGYGGDALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XK28</accession>
    <name>A0A6G0XK28_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_003924</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000047">
        <property type="protein sequence ID" value="KAF0740690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XK28"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002809"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01087">
        <property type="entry name" value="Prolidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF4">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="272"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0740690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="481" mass="53885" checksum="83121EE8ECA9F5F4" modified="2020-08-12" version="1">MHRLYNASLRHAYLRPAASAVQTRLRHQLASRNPFLVGESELVPGIEAVEVQLRRQKAVQLLPPNSLLILNAAEEKYMSHDIPYDFRQDSHFLYLTGLDEPDAVAVLKKNADESSEYILFVRPRDAHSEQWDGPRVDVHSARTRYLADAAYTLDELETHLVKLAAPETQLFLTSAIQNRYPSRFLAAAQSISQNHQFQMADSLLDQLRVIKSPAEIARMQEATSIGSDAFCSLIKGSYPGQLEVALAGHFEAECRARGAPRNSFPCVVGAGPNAAVIHYLSKRSMLRENELVLMDAGCEISGNYVSDITRTWPVNGRFTRPQEQLYSLILDVQLRCLERLRQATEQKVTLSLDELHRYSVGLLGEGMKDFGIVPNHVSLNSTEFHAIFRAYNPTHLSHYLGMDVHDTPRYSRSLPLQPGMVVTVEPGIYLPLQDTKVPAEFRGIGIRIEDDVLITETGIEILTSRVPKTISELESFVGSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XM39</accession>
    <name>A0A6G0XM39_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_003141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000036">
        <property type="protein sequence ID" value="KAF0741455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XM39"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0741455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="66" mass="7513" checksum="A6E63CDC63553FF2" modified="2020-08-12" version="1">MGFHRETALRESRRVVCEKVIRSHLLPPFAWILTVQLVGTPKDPTRDSSIDHPWGQHAPPYPTLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XMH8</accession>
    <name>A0A6G0XMH8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_003186</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000036">
        <property type="protein sequence ID" value="KAF0741501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XMH8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021065"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505:SF79">
        <property type="entry name" value="PROTEIN SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="13"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0741501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="272" mass="29509" checksum="54D575FF8DAE6A2A" modified="2020-08-12" version="1">MQAKHDAAAPVWIFMLFCLINYANYFDRSIIPGAPAQFQYFIQTVTSSNDMGTLLGLLAASFIMSFTISIPLFGYLAMFVQPFRLVAIGLAAWCVVVVLCSLSKDAQSFELLLAGRILSGVGEASFQCVAPPFIHDYAPPHQQTLCFDHGIITTGLECTFAIEGLAMLPFVGVCLYGVPAMYNAVPPSETTGETQRLLSSTETTPTFWAQLKEVCCNRIFLWVSAGGAAINFAMSGLGLFANLLLIGLKVFSNETDANVMTGIPGSKKFFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XMU4</accession>
    <name>A0A6G0XMU4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_003238</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000036">
        <property type="protein sequence ID" value="KAF0741557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XMU4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021877"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00251">
        <property type="entry name" value="Ribosomal_bL36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000473">
        <property type="entry name" value="Ribosomal_bL36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035977">
        <property type="entry name" value="Ribosomal_bL36_sp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052010">
        <property type="entry name" value="Ribosomal_LSU_bL36"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01022">
        <property type="entry name" value="rpmJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18804">
        <property type="entry name" value="RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18804:SF16">
        <property type="entry name" value="RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00444">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57840">
        <property type="entry name" value="Ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00828">
        <property type="entry name" value="RIBOSOMAL_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0741557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="88" mass="9875" checksum="3580EBD53500330F" modified="2020-08-12" version="1">MKVRSSVKKMCDSCKTVRRRGKVYVICDKSPKHKQRQGFHTTAAAAQPQVMPLSVGANPNNNFRNMMAQFPGLAGFQSFREAVTKPLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XMV4</accession>
    <name>A0A6G0XMV4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_003248</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000036">
        <property type="protein sequence ID" value="KAF0741567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XMV4"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0741567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="87" mass="9762" checksum="F558F7F28D65B600" modified="2020-08-12" version="1">MKFISVIATPATAAVMRGMKSHNTSQYNTTRPANWTNLTNWTHHGNWTGNWTNSSNWTSYNNTIGFNSTHGHLLHDDGFVVVGSHYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XN46</accession>
    <name>A0A6G0XN46_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_003009</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000034">
        <property type="protein sequence ID" value="KAF0741817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XN46"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012485"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052050">
        <property type="entry name" value="SecEffector_AnkRepeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586:SF3">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0741817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="570" mass="64230" checksum="7BA5C46803902777" modified="2020-08-12" version="1">MATTVLSSVDLVRLVCAFQRGLFEDTKALLLTMQRESDLEWSQADRDMERLHRVLEPWHCRFDLSRLELLRHCRSYRSLVENVVQEAVYYGRSAIIRAIDVSVLQSIRIPLVDLAALGGRMDMLRYLHEISHAGYSHQAVNWAAVKGDVDILAFLLHHYDIKATDMALHHAVEHRHLNAATLLWNHGYRPCSSETVLAVVKRGTVEMLEWLHLHMPHNVNFPPDTIDTMHMAAFHGRLDMVEWLHHNRKEGCTSAAMDLAARGGHLQVVQWLHRHRMEGCSVRAMDWAAECGHVHVLDWLHANRSEKCSGDALAKALRHQQWAAVDWLRAHYSDLSCANAMVQALSTDDLTTLHWLNQHYSTDMAWISAMDTAAIYNSMNAMTWLHEIRPEGCTTAAMDYALAFGHWTLVTWIHSNRKEGCSVHTAIRAARTGNLVCLEWLHANQPNCWSSAAMDAAAAAGRIDILEWFHANRGEGCSPKAMVYAAAEGKLAVLQWLHGHQVEGWSTDVMDAAGTAGRMEILKWLHVNRQEGCTAAALSGASKNGWSAAVAWLLKHHREICAELLDDGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XNL4</accession>
    <name>A0A6G0XNL4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histidine acid phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_003030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000034">
        <property type="protein sequence ID" value="KAF0741838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XNL4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000847"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF110">
        <property type="entry name" value="2-PHOSPHOXYLOSE PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00778">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0741838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="362" mass="40508" checksum="20E01AF621B35ED1" modified="2020-08-12" version="1">MELVHVLAVFRHGDRSPITNTVGPKLKMDDEDKQFWTQQLATETSRQYLNSITKIETDQGPPLPGGTYPNGHLTQRGVEDMTEKAREFRRRYATFLDGCNPHDQIYVCSTNIRRTLLSAQSVLSGLFPDDARVEKPLVIHALDPKLLTPHHTGAEMRRGLEALNEEAKSTLPGFASLDTTVKPLIGISPAGRVNWSALREVLDCKRAYKLPFPEGLTDDTYEAIVQHSAWEWYTLYSSPHLGQRGFVHGMRKIRALMEDAIASSPHRRLTLISAHDNSLVALVCALQLHHSSGFVAPPYGSMLVFDIYRDKADESHHLMIHWDGKKLRFPTQTTSLAPISMFDAVAKAFLAPHAPAQQPSSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XPN6</accession>
    <name>A0A6G0XPN6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_002553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000027">
        <property type="protein sequence ID" value="KAF0742454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XPN6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009359"/>
    <dbReference type="OrthoDB" id="41532at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47542">
        <property type="entry name" value="ACYL-COA N-ACYLTRANSFERASES (NAT) SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47542:SF2">
        <property type="entry name" value="ACYL-COA N-ACYLTRANSFERASES (NAT) SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0742454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="156" mass="17336" checksum="4EA28C19FEF96884" modified="2020-08-12" version="1">MQVIHVDEKTPRQALEQVVAIETASFPAHESLGTAIVDEAKKQGHVMLLAVDVASSSVLGYVLYSRNSIAGRVVKIAVHPSKRRLGIGRTLLQQAIRLLSNCMCITLHVAVRRDGAFQLYESLGFQVQDCRRDYYAKGHDAFFMELSKSDYSRALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XRJ3</accession>
    <name>A0A6G0XRJ3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_002117</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000022">
        <property type="protein sequence ID" value="KAF0743059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XRJ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015794"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
        <property type="entry name" value="FYVE_like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43102:SF2">
        <property type="entry name" value="GAF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43102">
        <property type="entry name" value="SLR1143 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="302"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="418"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="477"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="582"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="434"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="485"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="586"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0743059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="643" mass="72193" checksum="3AC8E75B259E0BD1" modified="2020-08-12" version="1">MQVVGNLMDSSLPMYVTRSSPDADDTIPSYRRWLHSVASKGFPPLIEEKLRHAAHIKSQELLFQDTSVASHHRHRQNSSSKSGSSGPVVSKNSLWTFNKEKNGVLLCHGYSASGEYMVKASVNASTRVAPLATMLDMNTSKAFNDTMSQLGSSWFGEGEVISSLREPSSVHDMYFRWMTWGVDADLKDFTFLSHTKLYDGQRDEVDGSMGDDDIEFMTQLWDSVDLFPLPCPHTERTVMKNSGFLVERTRDRDVCRVSFVLCIDRNRKREKWMDRMAYTLVHEIAVKCRDVSAIQVALKHEFGNEHHCSTCLKTFTMFRRRHHCRLCTGAICNVCSTTLTIGTTDRKAVRACLACSTSSNESTFNRRLLMTSRRYGRAVSAQYSIMDFQGDLRTSRKSGRAVSSHYSIMDTQRDLRSTNSSHIDPLAPSTAVPSPRSSSRSSNRSGRLLLDDIVAAKAIQAPPVPLPSSYQLLQHHQLPKKSFRSSTTTTLSSQELSPPTNEFAKLQAGLVLAMEDGQRSRQPSSRDSLPLESYAWEADVAPTAPTKPTNTAYVFQGGSMESRPDSWRRTEPRAVVPDLDEETDTFDMSSRTASSPRNDLIPLPRDLSQPFMSHNTTFRPPPSREQDSFVRPSLISVCSDYEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XRY3</accession>
    <name>A0A6G0XRY3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DEP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_002190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000022">
        <property type="protein sequence ID" value="KAF0743135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XRY3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015833"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04371">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEP" evidence="2">
        <location>
            <begin position="224"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0743135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="426" mass="47532" checksum="2252B41284EF6490" modified="2020-08-12" version="1">MMSRSPSKELPPRSASLPRTSFNGDMSSNAVDIDTLMLTINNAVAKIASIRESFEDGRPPRHSSTSSKGRSRKKAGSSVSATSFDDVLRFSSNSSTFQDRYSSKSEDSGKPPLAQHSSRSLSSSFNSNASSPSIAEHRKSPKPSSNFPDEDAAEDDVVGPEIVNVTRKTKLPFPYHKLQSTTSIELDENLTPFKELRLARLQDIKVQFHNGLPQEFYKAICRFLQTTLEIKRRFYKLKHLKECFLGCDTFDALIDNGFATDENEALLICNVLLKLEYIEDITGPPTRMKNRNDGFYKFGPAVELQTGQDNQAIAGTPNQASIDVADFSEASDEMHALISEESLAILARVLRRMFEKTNKIMLYKGHEGCFLGSELVTALREMKIAQSTTDAQMVGQSLLEEQLIISIDPDTTDFQSKYTMYRLANM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XS29</accession>
    <name>A0A6G0XS29_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_001871</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000017">
        <property type="protein sequence ID" value="KAF0743398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011685"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF145">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX57-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="700"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="931"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="636"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0743398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1638" mass="184350" checksum="666082F1C8B0AD31" modified="2020-08-12" version="1">MGIRGLTAYVAERQAECADEIEDLKNVTLGVDLDSFLHFACRELVNGYNAQWLLLGGDARALYVWVRTWMRPLFSRKIRLKFVRDPPGMLNTIKDVTHVKRSKEKADKMLSVQNGLNDKTGPKDDPWQTLQIKDDVAKTLVEAQAVFTLARQTLVRCLQHAGCSIVTAPTEADETLGDMVRSKKIYAVLAHDSDYLMMHKMRYIPFNSIRVNAESGVVSATVFIAEKLAACTSLAPDKLIEWAIVCGNDFTPYVDQHFGLAEKLHLPLLRQSQGYFNVGDALMWLQEHLGSSNWLDDPVFHELLKNNPDLLTHVYGIYCFYGAGDIVKSRFPSATRHKVLKPEDWKQVSKMLDKFMLPSFTIDVMYKQRRMLSWRSKLIGLSCPILDGMRQSLYRLMGQTQVEECEMDLESGEPIVRVVTLPASEMHIKTIRQHSKSARLDMAKSLALEWVASVPAVQNAFSKWKPPKGKDHLKFIGYAMGILLAAQPRGLTPKSWHVILLSSLICVELQKESTTHAFPLGVILRKEMVETTHRYLQTIEVLQHLYRILNLHLELNEHAFFSASVFCHVMAKYPWTKSTLQHALRDPIFGLNDDQVRDCSWGYYTIFHLYSTCLPADPSPPLTPAIVLNRNPAAAQKLKPKKLPPPKSVEASEAPTASPQKIDPLDWEDEVVSTPRAPPPKDLKDLIVTLPVFNHKEEILTHVAANPIVIIQGETGCGKSTSVPQFLLDSNSETAKIYVTQPRRVAAITLATTVAKMREQTVGQTIGYRVGQIQKDSDETQITYVTTGYMLERLVHNAESVSRVTHLILDEAHERSMDMDMLLLMLATHWHMWSDLKLIIMSATMDSSIFFKYFKPKLPYPLKQKEELFVGSALHPVRSIYLEDMKGMKELKVGKLVESLNSWARADMNDIEVVIKKLQNIVNPQLELCVRIAKMIVDTQKGTGCILIFVSGLTDIQFLHEQFEKWSSIKLFVLHSDIELDDQAKAFEGVDRKTKIILSTNIAESSVTIPDVTHIINTGLEKQIVMHSQSHSEILVRSWCSRASVKQRSGRAGRIQPGVAYHLFTKQFMETCMDEYTTPELLRKPLDKVVLQLKSQLHHIGTPTELLSKAISVPDLANIQSAFNVLHLFSAVESPNEKDAITSFGAFSVHFPLDIRLCRLLMYGLSASDWGIGVVDVVLLVAVMASPDLHLAPSRFHTPSAAKYLNDMKLSLVAKLDLQEGNVWSESLAMWQLMVQCLTCKSKGEVISLLKNFAISFRRFQTTLVLVGEICSRLMRLAKTPQYKNIRVLNVAAIKQLSLLQKFSARMYSPEPWKYSHAPLPIMRLLIVLNYSDCLARGRLPDNKKGESKGKKDSEPLLSLALKVDSSCTWGTNIPAHHFKKLLDALVREPEDMNVVKGSSLFDIKYRQSNPVPFSASLLYFLRDRRFPVDLPVDPLWKPAVGDPDALRVRFTDAGFRPGGVLSWTQWTSGIKLNVSGRSVFGLPQAKLQKKVVAAIFSEQLLTGDGSMMMCGGCTMLPPDVESYAAIVMLMTAKRNVWIFVDSKLQYWSAIKVDGCNCSLDDCVALHPTLDTINLVRRELSRGLVQSLPTARDPVARISGEDMDALFKTDKKKLDGMKWIQLDFDTSTKLPFPPLVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XSY9</accession>
    <name>A0A6G0XSY9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">PRKR-like endoplasmic reticulum kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">Ae201684_001381</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XSY9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021270"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004694">
        <property type="term" value="F:eukaryotic translation initiation factor 2alpha kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13996">
        <property type="entry name" value="STKc_EIF2AK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF160">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0652">Protein synthesis inhibitor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="20" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0346">Stress response</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="13" id="KW-0834">Unfolded protein response</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026050054" description="non-specific serine/threonine protein kinase" evidence="20">
        <location>
            <begin position="20"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="564"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="429"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="489"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="693"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="823"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="515"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="823"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="593"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAF0743724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1049" mass="116508" checksum="D46EEE7EE376DB24" modified="2020-08-12" version="1">MRWSCRWGVLSVSSWYILARGIGQEVNRERDARSTEIRLHVEKSREQAVLLVGQMSGHLQAFDAWTGQVINSIDSGGPLVTNCREDIIQDLQPDADSLQSIRQQARTDVALHSPQFDQHNFAPTMDGRLYHMSKNDGEWKEVHLPTSELLQSKKPLRSKDNPELSNVLFVAEKNQRLYTFEPDTGQIYPFFSADAASSSSTPRDSINILMGRVDVTTKMLNLDDVLDFKCVTVSEYFVQFASSAQCGKDTTVVAAASPGIKMTVGAHGGVSLTAFDPRSNAMLWTWESPFDLTMVYGILPSQGSKFFEWSVTGASPGSDETCSTWNEEPASSSDRALMPMANTNLLYRAIDGQTYLLPSPAEALVYQPDNLTNKVVKSRPWKLKSVEVDGEKGFLLTSQHVIAIALAVVVVITVVAHYFYRQGLVAKPRSSSDDESVVSSPRNISTTTPPSTPTLAPSQNPKSPLQRHKTGLDHLLRLVSPAKMQRSLSFGGFSHAPEHHHHNRTSVKSPWANDVNLQRLSDLSNDPSMDSTQSDPIKSQSLPSNEELNKILPYICRGRFANEFDELSVLGKGGFGQVMLAENRLDGRRYAVKRIGLCLHNQPKPTLEKFLREVKILARLDHSYIVRYYQAWLEALGEHDIVPTPSETTSVFSARHETTSSVYTSRNILQHRSSDETSSSDSLYAPRRFAANFDDDDDDDAGGFTWDRSGEETQGNPWSESDVVHESSLETLSVRTQDGRVDHWLYIQMQYCSEQSLADVLATTRPPFHHVLEIFYQIASALEHVHSLGLIHRDLKPANIFVMDHNTIKLGDFGLSRYASSPAPTSSNGAMDLDPSTSQDSIWSSDEEKTAGVGTYLYASPEQISGEMYSAKADMYSLGMILFELMHDTFGTAMERIVTLRNVRDGVLPPKWLPDHPRVVAMIESLVAKRPQLRPNAHDVVVWCQAQLQSKSTSVPTTASAARKENVHVLQVEPKDGKNSNLCHNLLLTLSDVIRMMEPPVAIVACGLKQHMSGQVLEFTLQVESNQELLEAKAAMAACSGVHHVELLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XW47</accession>
    <name>A0A6G0XW47_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_001146</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XW47"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007964"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052050">
        <property type="entry name" value="SecEffector_AnkRepeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586:SF3">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0744689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="767" mass="84894" checksum="23A01D4429FC1294" modified="2020-08-12" version="1">MSGDVAAQGLLTLFPCIQAFQAGVHRDFIPFLVLQTPKQHNPFNNFALDHPKFEKLNAALTPWLDEYGLSRLPTLFKAMSFMKQNVLLHAVYEGHLHLVEHLDDHFDLLQAFGLNLIDIAASRGNMPLVVYLHERGHPGCTKVAMGGAAQNGHLDVVKFLHSHRQEGCYRGALETATLGGHLEVVEWLCGNKIDPCTDVAAKFAVESGHLAIYEFLLDHGAYEPRDLLDGKVFAKHMSDDLTTAAHHGYIEMARYLRDVMNAQWTSQAFDDAASQGHLDLLVEMSTSDVHGSDRALEGAAGNGHVHVVEWLLERQVGLEAQNAINRAAQNGHLDILERLFNHGFRHCTAASFDRAAGGGHLQVLKWLHDKLHQTGTPRSVGAAVARGSLEVVQWLVAQFYPDHIVNLDTAAANGHLETMQWLHEHHVVSCSHRAMDFAATNGNLEVVQWLHLHRTEGCTTAAMDSAAAGGFLAVVKYLHYHRHEGCTAYAMDAAARKGYLHVVTFLSENRTEGCSSKALEGAVEIGHVDLVRFLLRHHPNETANLLDIAAAHGNLEIIQLLHEEKNASCSIAALDGAAKNGWLAVVRFLLDHRTEGCSFRALQETLSIPVLELLVKRMTWTLANFGNLMLFGATHGYLNVVEWAYSHGGDECRASAHVMDAAAEYGHLHVLQWLQGHRNDGCSTRAMDRAARKGYTEIVEWLYANRYEQCTIAAFGDTAFRGDVRMLAWLCNHMQSHEGELKALDVATAYSQPHILAYLETRGVSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XWY4</accession>
    <name>A0A6G0XWY4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_000622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000003">
        <property type="protein sequence ID" value="KAF0745045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XWY4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001745"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="558"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="331"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="568"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0745045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="602" mass="67847" checksum="D815DF879149B127" modified="2020-08-12" version="1">MAENPHFAFGNRGVGRPTASEASPSLAMTTGLTLQHLYSQQQQYSQQGPQSNVQQPQNMSSHSHAGPPNNGHPGARQLPLNSMNKSHGPPGHLPHHHMNNGNQSAPQHGNHNMHNGSGNGEEFVADPLPFNYEEIEATGVFDDRYGARNGGNRLNGPPPNDKNHHAPPQQTQHQMRYGSLLSGMQQQQQYHDSNSYDDHGYDSRRDHNSIDRSNGHIKEVPSYNHYMPHSHAHSDHDSRPPSHYGIPELHSNMNHNNLHPLYHQPPPYANNNGPPQPPPHNPHSYSALMDSHHNGNMGSMPPPAAPQQTTTKKEIPQSYHNEYIDSRSHHSTSVVPHMPSSSSSMSHHMPPTNPSMPSQTQEAVIKVKTSLKNKYWRNGRRNLQCFPSCKVFGDYSQIKIDDLKQHDFMWGKCRGSLIAEVTLNSNATFDDILLLGRVHSLENIPVPFDEAVIRECMIGRVVEPDIMDIMKEQWIAGERLPDFINQNNNMACYEFKPKVWKYTDDMVHGKCKRRNVRYYVQFEAFVPVLTGDRRCYVCIGSGMSSSFEVGSSRVLARQKRKAHNNAGDEGEERESNEDYEQNEAENSRPAKKMAPMMNGYNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XX33</accession>
    <name>A0A6G0XX33_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SMP-30/Gluconolactonase/LRE-like region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_000666</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000003">
        <property type="protein sequence ID" value="KAF0745095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XX33"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005700"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051262">
        <property type="entry name" value="SMP-30/CGR1_Lactonase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47572:SF4">
        <property type="entry name" value="LACTONASE DRP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47572">
        <property type="entry name" value="LIPOPROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026124499" description="SMP-30/Gluconolactonase/LRE-like region domain-containing protein" evidence="4">
        <location>
            <begin position="16"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="572"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="5">
        <location>
            <begin position="282"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="538"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="232"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="538"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="557"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0745095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="616" mass="64336" checksum="B2D97D851C45D024" modified="2020-08-12" version="1">MKLLAALATVAAVQGLKLSSILYERYGVDDLPIIFADSPSNVLPISYAPGATAAPTPAPTTTAATTTAAPTTTAAPTTTSAPSTTSTSTAAPASSTTSAPTTASPSTASPSTAAPTTAPTTAAPKTSAQSSTATPSTSSAPKPSSAVDLFAILRQSAQDFTNGQGNTGTDSSLRQLDSTETLTIVEDNNGPSQSGGRRLDDASNRDFTLSLYFCNAKSNSIQSYTSAKPKKTTVSSTTSTISGSDQPDAEGKCYDYDVKVDTVSVTAGCNLQNHPEGCDNLYYPGCGGLSVDPKSKQIYVARSGGRSIGKLNYISSGGSCSGRVLDWLIRYRGKKFNGPADITFTSNGNLYFTDSPFALATSGEELLSTNLTVLDSRREIPFSGVYVRSGSVTQVLDSTMTRPRGIALTAEEDILYVANADATHPYIKAFKLYPNGTKECARRFFDFTNNPLNVTGASTVNATCLRKYPSSIKVDSEGFVYTAMCNNIYIFDAAGTLLGRLEADAEVHKLAFGNGYIYISSQNSIFALPVDMSFGNSQETVPNPQDSCDATTTSTQSSESDVSPSKSSSTSTVVGTVGALAAVAAVALFVRKNKKLAQDFSHVMTPPTTAVKSNVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XXM4</accession>
    <name>A0A6G0XXM4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Translocon Sec61/SecY plug domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_000300</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XXM4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001620"/>
    <dbReference type="OrthoDB" id="420669at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3370.10:FF:000002">
        <property type="entry name" value="Transport Sec61 subunit alpha isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="entry name" value="SecY subunit domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019561">
        <property type="entry name" value="Translocon_Sec61/SecY_plug_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006341">
        <property type="entry name" value="PRK08568.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="SECY/SEC61-ALPHA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10559">
        <property type="entry name" value="Plug_translocon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="Preprotein translocase SecY subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="414"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="439"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Translocon Sec61/SecY plug" evidence="12">
        <location>
            <begin position="39"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0745269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="473" mass="51506" checksum="69E38133E76C5876" modified="2020-08-12" version="1">MVRLLHVLRPLMSVLPDVSQPDRRIPFREKVVWTVVCLLIFLVCSQLPLYGVKNTSASDSLYWMRAILASNRGTLMELGVGPIVTSGLVLQLLAGSNLLEVDQSSKEDRALFAGAQKLVGVFITLAQAIAYVFAGMYGDVNEIGAGSAILIIVQLFFAGLVVIALDETLQKGYGFGSGVSLFIATNVCQNIVWDTVAPVSITTGRGTEYRGAVVAFFHVLIARENKLNALKEAFYRQNLPNVTNVLATALMFVLITYVHGFRIDLPIKYQKFRAQQGAFPVKLFYTSNMPIILQTALVSNFYFASQLLFKRFGDNIFIRLVGVWSDVEGTTGAIPVSGLAYYISAPGSAAAILYDPIRAIVYVAFVLGSCAFFANVWTEVSGSASRDIARQLRDQQMVMKGHRDTSVVHVLNRYIPVAATFGGVAVGALVIISDFLGAIGSGTGVLLAVTIIYQYFEAFAREQTDLQSLLGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XY94</accession>
    <name>A0A6G0XY94_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">F-actin-capping protein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_000492</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the F-actin-capping protein alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XY94"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002335"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030863">
        <property type="term" value="C:cortical cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008290">
        <property type="term" value="C:F-actin capping protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.210:FF:000003">
        <property type="entry name" value="F-actin-capping protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.60">
        <property type="entry name" value="F-actin capping protein, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.210">
        <property type="entry name" value="F-actin capping protein, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002189">
        <property type="entry name" value="CapZ_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037282">
        <property type="entry name" value="CapZ_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042276">
        <property type="entry name" value="CapZ_alpha/beta_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042489">
        <property type="entry name" value="CapZ_alpha_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017865">
        <property type="entry name" value="F-actin_cap_asu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10653">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10653:SF0">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01267">
        <property type="entry name" value="F-actin_cap_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00191">
        <property type="entry name" value="FACTINCAPA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90096">
        <property type="entry name" value="Subunits of heterodimeric actin filament capping protein Capz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00748">
        <property type="entry name" value="F_ACTIN_CAPPING_A_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0117">Actin capping</keyword>
    <keyword evidence="4 5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0745478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="281" mass="31550" checksum="F9724675CD2C6655" modified="2020-08-12" version="1">MEEVSDTEKLRLAQHFLLSTPPGEIRDVVKDVTKLLPGGLLSDSVLRGAMHSYSTESNLPVAIPSGESHHLIICKEGEVDNGHYLDTKTQKMWGFDHIKQEIVPHDVQDASVHFQSALEPVRLSIQSAVDEYMANQFGNQGGVAVFANDSAITIVISTERVSLRNFWSGRWKSKWMLTNVSNSSATVTGRIDLHVHYFEDGNLQLQSNKEVSRSIQGASLAAAIIDAIREEEHVVHSNLEDMYINMSEETFKEMRRVMPVTQTKMDWSIHAHRTAKDLGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XYB1</accession>
    <name>A0A6G0XYB1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">Ae201684_000001</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000001">
        <property type="protein sequence ID" value="KAF0745545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003339"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008331">
        <property type="term" value="F:high voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000009">
        <property type="entry name" value="Voltage-dependent T-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031649">
        <property type="entry name" value="GPHH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050599">
        <property type="entry name" value="VDCC_alpha-1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002077">
        <property type="entry name" value="VDCCAlpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628:SF7">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16905">
        <property type="entry name" value="GPHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00167">
        <property type="entry name" value="CACHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15 16" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 16" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4 16" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="18" id="KW-0732">Signal</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="9 16" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026145511" description="EF-hand domain-containing protein" evidence="18">
        <location>
            <begin position="20"/>
            <end position="1528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="321"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="532"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="620"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="734"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="771"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="804"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="868"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="992"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1034"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1114"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1144"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1223"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1317"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="19">
        <location>
            <begin position="1366"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="1006"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR602077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF0745545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1528" mass="172374" checksum="16E28DE44557A3D4" modified="2020-08-12" version="1">MFVVLVNTLVLSLVDYSDPWATGPNPNKLRNVIVSRTNDVSLIIFSTEAFIKITALGFTGSFSYTVDNWNKLDFVVVASGILTRVLEALDTGSIVGLGQLRMLRILRPLRTLHSVPGLKVLVNSILSSLPALLNVTILLTFSYLVFAILGMDVWAGSYHGRCRLTEYPVVLDFNASNAPPDYTYPNSTYINLVLANPERYRCLNMSNDANEWSRQNCFWPLDPSDTVGLYCGSRKCNAGTFCGSNYDTWGLPRFNDIYVNGTLVYSITDEADFTPNLNFGLTSFDDIGSTMVIIIQVVTASGWMVLTENTQDSFSMAIGGVYFNLVLFIGMCFLLQLNMAVVYYEYQKAKELQEMQRLSSMPPALRAQQSWSYRRSSVERLFKTQEFKQEHAPGGSGLIFSMLRKHAVRVAASSYFKNAATIVTAINVLLLCSDHYPSDATFEVWSELVNFACLVYFIFEMAIKVAAGGWRSYLSDKFNQFDLLTILAGIVEFVLNPPRFVDGTPGNTSPIATFRLIRALKLARAWKSLNRLLVAIMDAMLEILNFLFFLVLFIYIYALLGMELFATKFQFDANNRPLPFNNTNPTSNLHRTNFDTIYNACFAVFQIITYDNWPAVMYDAWLSTGVIAPVYFISIVVLGVWVVMNMFCAIMVDSVTEGVDQSDHGDSDEERARRTRSKLKRIFRLVLAASRFRASVVYPDKNKGPLDHGRSLGLFRPSHPIRRACLYLVRHPRWNQAVICAIVLSCIFTALDTPLQDSTHGIGLAIDTANSVFAALFATEMAVTVVALGFVMGRNAYLRDPWRMLDCFIVVISILSWVIGDQKVGALSGLRSLRSLRALRPLRVINQLPQLKVVVNTLFRCLPDIGRMLFFLFFMLLLFAVPGVLFFKGAFSTCSVSPYNYLDNDMYSPPPMWFPPSYNGSYAIEDLRAVDIMTFPRPWEEIVPSIQQLLTSSCNMTADSLAGQRFTPTSKQVCECFGMTWNPVVPQRFDNILLALGSLFELTTFEGWTNVALASVDATGPDSQPIPNYQPLFMIFWVVFIIVGAFFVTNMFIAVLCDSFMREKYGALVTDEQIAWIKDQRKVLSLSLVVKYDPPKAQWRFACFQIVRDRRFEGAIIGCILLNMTAMTVTYSGQPQWMTAAINALNKICLAIFTMEAVLKLAAYGRSYFKEGWNRFDFVIVVLTAISELLPQNSSFSAGATAIRVFRVGRALRLINKARLMKSLFNTVLVSLPSVGNVMGLLLLMYYIYAALGVQLFARLDYGPSTLNSHQNFQTFWTAFQILIAFSTGENWPNFMWECYGSSCPGNSCATWLALPYFYSFTLFVGYIGLNIFSGNNAHHGFILRLCTAIIVDAIGDDGKSPVTPETLEAFGAKWAEFDPRGSGMVTIQDLVVMLAQLPPPFGFKYVPGFTQRRIQKAVGDLNIPIYDKVYVHFKDVPRALVQRTLSEGNKKRFDEISDMMSRLGIDQEFEAIWKRTHRKKDVAALSMRLKTPVKDVIASHVIRKFMHQVTYRRRRQRRKRSMTKFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W465</accession>
    <name>A0A6G0W465_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_019117</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000398">
        <property type="protein sequence ID" value="KAF0721491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W465"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010307"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0229">DNA integration</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="11">
        <location>
            <begin position="160"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0721491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="666" mass="73297" checksum="87D4DDAA84F4B567" modified="2020-08-12" version="1">MLHLMEGKKWGLGMARHVPDFDANLVSVTQLTQEGKKVTFEGTTCDISQNGKVLATAKLVGRLWEVDCVPYKWDGDERGDARPENSTIGSAIVAHKSADTLQGWHERLGHLHNQTIVTMANQRAPSEMTITRIANDLKVPCLGCALGKHTRSEQSKEDTSQSAPSEEIGSVVCMDLKGKIKPRDRLGNQYLAVFVDHASGFTAAVPINKKSEAGRECKTFINALERAHNVVIKVLRSDRGGEFLSAKFKSYLEDKGITHQTTQGSTSASNGKAERMIRTLMDATRTMIFDCDLPPTFWSDAAKHAAYLRNRAPTRSNAGYLSPLEMLTGEAPKVNHLLRFGSDCTVHAPPAHRGIITRGELGRVLGVNPTIKGYDIWVPRLGKVLTTRDVQNVTYTRASTRLSDVPESDLSFNRVQSKTTATKETPTSTKRVHFTRSTAGANASMATMTAEEPRAPRSPVVYDGDEGSYALIATITKDPKTVREALSGPNAAKWTAAMKAEIDSLIANGTWMLVPKPPGTNIVSNKWVFKIKYDSLGAVEKFKARLVARGFSQQYGVDFSETYSPVIKQAAVRFIFIVATLYGGIVEHLDVPQVYVRTNIDTPIHMEVPAMVDGDPETQALLLLKGLYGLKQSRRLWNKDINDTILSLGYQKSKLDACLYFKTIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W4W4</accession>
    <name>A0A6G0W4W4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_018690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000349">
        <property type="protein sequence ID" value="KAF0722053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W4W4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018239"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050167">
        <property type="entry name" value="Ser_Thr_protein_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23257:SF706">
        <property type="entry name" value="PROTO-ONCOGENE SERINE_THREONINE-PROTEIN KINASE MOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23257">
        <property type="entry name" value="SERINE-THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026150515" description="Protein kinase domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="224"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0722053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="498" mass="53725" checksum="F325F6E61D5FB054" modified="2020-08-12" version="1">MVCRKSLAALSAALFAAVQATDNSTEASCLFDCASTNTTSCDSLSSDLQSCSPFQAICPNVTMQCTLQLDDNITLPWKNDTQVVRGCRIPQKAFTTVLACFNSSFNGSLGSYLPPQPTDDSITFPPASEPIVNGTIAPSDISTKSSSSSTQNTIIAVVGGILALAAVSLLFVYQRRRRLFGTNQPNDAEEALEEAIDVEGYILSASPKHNPRSFVESLPSERAFQSLWLNVDGARTPPLKGSHGLLQVTLEGHKYVLKGIDTSTTSEANLFAFSQAAQSLLALPSHANVTRIFGVAFIDMSSTFAVASEFMNKGSLGAILLDKAIDLDQAQRRRMSLDIAAGLLHLHGQGITYGQLHPEKVLVHASEALSGSFVCKLNAFAVMDQTFVANRQCPIRLGAMLAPYLAPEQRQGGQDRTMASDVYTLGVIVAQILTRKMPFEHIYHTHGFVRGDLFVLQNPSASPFEDLPADLRQVLVSCWNAAPERRPSCAHVVQALRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W678</accession>
    <name>A0A6G0W678_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_019041</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000380">
        <property type="protein sequence ID" value="KAF0721606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W678"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006536"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013992"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF37">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="573"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0721606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="779" mass="88320" checksum="925536F853530D75" modified="2020-08-12" version="1">MEAKTRQASAHFNKPFHPDEFKQLVSLDNIACPELKKPDLSEMKSFWKKYVRYRKELDEKYKMFGGSVAIQFKNVRQCMDEYTFESLCLYRWWTRDPDDVSDEDVNCLFEADCLGSKVDIKIFLDKLEKDLKMDKSVTRYVLSLASPSYYEIEVEAARRYFLNALEPISVRKKISTELRFSKKRYMVWKDFVDLCIDYMKTWCMYEDVFKSDTRPEAKPEARKKFDRPSQKPRVEKKQAESADTAAPGDAKAKASKPSYTCLKCQSVDYNVWKCPKLKDEAEAKSLLKAYYDAKRVAKPKKPNVDSLLSATGSDFIQAVCAGLEMKVLFDSGADVCVISRDFVRRATASGSTLHLKPLQAPVTALAFNGTPVVIRDGVKIDLSIPTNAGPIDMTNLRCWVQDDDLPPGCADLLVSKSVMRQLGFDQQTLLLNAQSIRPVWDFEPEYDPTTGQRLVGSLRVNAHDDLIHDGDEMCLPRPQPLDQQKIHVRNILDGKLEVAWQNGMDPVAHAKLTSLLTKFEDVFRIEIGRDPPVKVPPMVVKLKPGATPVKCGARRYSLNHREFMKTHMEDLCEAGLMYYNDSSAWASPPYIVAKPGTNKYRMTVDVRSVNSRTEPVQWPMPVIEVVMKNLAGSTCFVALDFFKGYWQFPLDPSCRDLYTIMTDLGCYTSNRIPTGGSGSVAYCQATVTNMFKSILYKCLLVWIDDLLVYATTHSDLMNCFEEVLSICSETGLKLNPDKCEFFATELKWCGKLVSGSGVRHDPGRIAALQSMSLPRTGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W6F3</accession>
    <name>A0A6G0W6F3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_018267</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000327">
        <property type="protein sequence ID" value="KAF0722668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W6F3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018200"/>
    <dbReference type="OrthoDB" id="103393at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0722668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="84" mass="9526" checksum="C5C742670796845D" modified="2020-08-12" version="1">MSSGDGYDEVYRLKSNHKELLMHKHTLEKQLEMKQTQLKELKKAIEACQAQLEDDAPIVRKRDRSSISSSTPIAPAKRMASLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W789</accession>
    <name>A0A6G0W789_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_018782</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000355">
        <property type="protein sequence ID" value="KAF0721960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W789"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005674"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF288">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="29"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="353"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0721960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="618" mass="70264" checksum="D02ADB5AB57CEFAA" modified="2020-08-12" version="1">MHFATKKGFFYIVQELLAHGASPDSKDEYDNTPLHIAALRGDLQIIQLLMKAGADSLLTNQKNETARDLGNDEVKAWFDNYQPKTNALISTTLTENINEGTYSINAAFDVIRQAVVDTKEIPSEIIRSASAIFKMTLEIQIHKESVLSTALTVERIARHLAQQENAMNIPNLTAAFINIEKYWETTLLSTQVWKLLLNDAEEQAKIQAMRAEMHRLQNNLLQAAENLDVDLNIHVVGSIGDMRQDIGNMMVKMQSLGEYLETISNLHDVRQQRDGIIELAIQLQRGLEYYERQVTLGNVLHDVNFENQVKSCQNLIGDSIQEMKDKKKTPKNFGLDMIATWMLSSEDIQFDGNDRASILGQGGFGTVFKGTYHGQAVAVKRFDQILLTDSTDLERSIAKEIKAWKDISHKRYILTLFGVCTKAPTPILVSELCQTNIRRYVRDWPEMLLPMVYQFACGLVSLHEANIIHRDLKGDNVLVTYQNILAIADFGLSRTVESLEETKTGMKRAGTLNWMSPEQYFKPRRVTTKSDVWSFGMTVWEVLTSDTPYRGCSEHEFAEEIFQSEEDRPEKPQDMDPELEPLWTLITKCWQLDPTARPTAVEIVEFLKSQFGSKLAEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W7U5</accession>
    <name>A0A6G0W7U5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cAMP-dependent protein kinase regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_018104</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cAMP-dependent kinase regulatory chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000320">
        <property type="protein sequence ID" value="KAF0722873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W7U5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010649"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004862">
        <property type="term" value="F:cAMP-dependent protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034236">
        <property type="term" value="F:protein kinase A catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000039">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050503">
        <property type="entry name" value="cAMP-dep_PK_reg_su-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012198">
        <property type="entry name" value="cAMP_dep_PK_reg_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635:SF152">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000548">
        <property type="entry name" value="PK_regulatory"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00103">
        <property type="entry name" value="CAMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0114">cAMP</keyword>
    <keyword evidence="4 8" id="KW-0116">cAMP-binding</keyword>
    <keyword evidence="6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="96"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="217"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="20"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000548-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0722873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="351" mass="39463" checksum="7491CD4F9BCC2C07" modified="2020-08-12" version="1">MFDMLKKKYGRFFCCCKESSPTPGEKRLIQDISPDDTETSDEEETKRRIRARNQGRRPSVSSGSLSMVDPMQCRKRIPKSPTTVERIKSAVACNFMFSSLEPQDQMDIIDAMEERRVHVGDTVIKQGAEGDYFYVIEMGEFDVFTERSPTTPVFHYSNGGTFGELALMYNSPRAATVVAASQGALWALDRDTFRRIIVTANQKRSEMNEKLLAGMELMANLTHAEVSTIADALQPAHFEPGDVIIRQGDSNYSLFHFYILVEGSCNFVYTDEHGESSVVGQVQAVGYFGEKALTEKSKRAVSVIATTDVKCLSMDVATFERLMGPFQEVFQRKITSYANARDVHAENRTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W874</accession>
    <name>A0A6G0W874_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_018461</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000336">
        <property type="protein sequence ID" value="KAF0722392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W874"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014726"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000002">
        <property type="entry name" value="Transmembrane protease serine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF98">
        <property type="entry name" value="FI18310P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026129406" description="Peptidase S1 domain-containing protein" evidence="7">
        <location>
            <begin position="17"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="20"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0722392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="269" mass="27627" checksum="BF3C16F697A7053D" modified="2020-08-12" version="1">MNILFALSALLATAAGQLEIVGGKEAAVGKHLYLASLRTSTGGQTVCGGSLIAPNVILTAAHCSIETNYAIKYAVIGTHYNGGTTYGETIAVKQQIVHPKYNKNSNTNDFAIYILASNAKTAPATVSFDTVSASVPVVVRGWGATSEGGSESSALLELTVNTLTNTNCASLLSPYNVDSTMLCAGGQAGKDSCQGDSGGPLTLESSGSEKLVGVVSWGLGCAQANKPGVYSRISAAKDFISPYLPKRVAAFEVDVVEVNNSTDAVPTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W9C1</accession>
    <name>A0A6G0W9C1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_017374</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000295">
        <property type="protein sequence ID" value="KAF0723798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W9C1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012581"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF440">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0723798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="33522" checksum="FF0C345C564924A8" modified="2020-08-12" version="1">METKISLKRQGNAEFLLGVKISRNGNRITLSQTAYISTVLKRFGMDKCAPMQTPEITGTEAKWGEPDSPDASMETYRAIFGSLVYLTTCTRPDLAHAVQRLSRYLYAPKEYRMNGAKRVMTYLQRTKNFEMQYGNEQDEITLHSFSDAIWAPKPDRRSVSGHIWLVGGAPVSWRSTRQRTVATSSCEAEYVAMAMAAKECVFLRGILKDIGCPQETTTCYGDNQGAIALTQQKVTNDRSKHIDVAWHFIRDMVRDKIMAIIYVPTKDMLADVLTKNSTRDALERFLTAINMVPGHGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W9L4</accession>
    <name>A0A6G0W9L4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_017280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000292">
        <property type="protein sequence ID" value="KAF0723899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W9L4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016064"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="506"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="538"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="591"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0723899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="751" mass="83159" checksum="774CE2DBD72F096F" modified="2020-08-12" version="1">MPTTGPTVADIAASYGGDHLLNATANSKDDDMDGRLHIASNSSTNGPFVPVSKRHKRKELCKWIVRVVWWLICMSIEIVAYLVVPYWAYMDISPLVANLISPSYSIMAGIDPGPTMAAWDVSLYTGYNTTAHENEIVLRRLIDQVDSMPRGSQIDISVNQTPFLMVVSTKMIFYQSVSKTNQAVDATSGRYTLLVGKKFTISEPVFDHDESLVLYVRVDNKVHGYTALRVLQAVNSSETHQTLVDVSHVYPDLLGSAKFIVCTTNRDAGTNRCGNIILPKATVDSLIIDEQKTFGSPETPPSCTHPMMPTVVYSIIDIQRKTFHCASDPSSIVALYAFENLIAVIAVPSVPNQALFGAGVNVPTGFRLPLRGVGFLDATPNATAVMLPYLQGGNFMWIGETSRIDFIIRTQLATLFVSRVATTVGYMLLLVKYSWKSGKSFLGLLVDYMTLEVTNKSFVDTTIAVTLVTTYWQYRDMMLAMLVRQLYATIPWTGSILHSYEDDLRFIPGPVCFLFIIAMSAAKHLLNSCRLCIRLSYVAMYLATIILVTGALTHQGPAVTSIRSADPYALSPSLVAPMVLSYYRTSPHLDVYYFMGYAAAVAIFVPLVLFQSCHVYRSRQRRTHELATPYTSLDVAVGLAIRYPGGFMDKSRMYTAGKHPDGVKSTVYSLAMAGYITVDGCLMLTSSVNRCLAAYVLGSVMDTSGPIHYFQLTDDGTAVKNTYQLRTFPTEFIRHRPLWRLIKSISLCELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W9Z6</accession>
    <name>A0A6G0W9Z6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_017208</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000286">
        <property type="protein sequence ID" value="KAF0724043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W9Z6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008610"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF97">
        <property type="entry name" value="GH13245P2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026185442" description="Peptidase S1 domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="39"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0724043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="160" mass="17672" checksum="A92850C949CF2334" modified="2020-08-12" version="1">MRIWPWLLIALVKLEEIQAQRRPKRPRRRFRNKTVKREIVGGLKAKIGEHRYLAGLKGSENEQTEFGSTLIAPKLLLTAAHCALDKIKVAAIGTHYNTGCEGGELIKIAQKIPHPKYNGEPANGYDVAVMRLATASKITPGKLSFDPVPVGTPLTVRGWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WAS3</accession>
    <name>A0A6G0WAS3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">rRNA-processing protein FYV7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_016872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000270">
        <property type="protein sequence ID" value="KAF0724465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WAS3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000348"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013730">
        <property type="entry name" value="Fyv7/TAP26"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08524">
        <property type="entry name" value="rRNA_processing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0724465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="166" mass="18960" checksum="C49E0B2BFBFAEF01" modified="2020-08-12" version="1">MKAQGSGLSLERFIRGKARPNKGKGESAAGKRKRVEKAVLLRKYRKEVGHVATNEEAQTKAPTSFYDKFFSQVQGEENDASHEKTSLASLSHKPDPLFKAKRKAQQAKDGRHKKRQVIEEKVKEKEKKVEKRKKRHVKLSLRTKTRQPVVKHQIKDILAKLKATAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WB53</accession>
    <name>A0A6G0WB53_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lipoxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_017621</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000305">
        <property type="protein sequence ID" value="KAF0723466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WB53"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013104"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034440">
        <property type="term" value="P:lipid oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.245.10">
        <property type="entry name" value="Lipoxygenase-1, Domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000907">
        <property type="entry name" value="LipOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013819">
        <property type="entry name" value="LipOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036226">
        <property type="entry name" value="LipOase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11771">
        <property type="entry name" value="LIPOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00305">
        <property type="entry name" value="Lipoxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48484">
        <property type="entry name" value="Lipoxigenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51393">
        <property type="entry name" value="LIPOXYGENASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoxygenase" evidence="4">
        <location>
            <begin position="655"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0723466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="950" mass="107397" checksum="58453F6497F1F248" modified="2020-08-12" version="1">MGNHPTTLRPTTDTAAVQYLSPDNNAPEGYESVLDYAMAHEKVVGFFGDEGVKLFDSLMDDGSLSRHGAMPPGLIDLLGPILQSLDGKEFETTKAALVKALSGSQLEVYKSTIRSIINDEHHRWVARGGVISLAKLSRELVFKVILAIVFGMDVQHDQSELRAQVDEFIQGMHQSLAHVDNGAKKLREKLIESLVAPSLASARNRVAQGKTKPCVVDVLVSERQLDEQVLRVHVFHLFVNGFSGIDSMVVNSITAMCLNPQVHDQLMAARDAFAAKYTSVDDRWNHLDDLGYIQRFLKEVTRFYVEGTTHLYGRATRNVQVVVGKHNSFDLHKGAFATAILDSPTWTNASKFDPDRFLKQEHIELFPRTIDEHVKTLIVQSAFLSLLDFEWKMLPLQDYTVGPPHGTPVGGLMAVNFRHRNGHDGQLFEVAGTRADWTFLALPEAKVYRDDIESFHGFFTDSRLDLWTHMMLQLLQVKQTGWSTPKASTALKIPKYQKVLPKINLKGTNIMVPTEDEDTPLDPWYEKALMVLLRDTLPICDNFTDNWLPGEDMEAYVMSKVGKMWPRVLVHWNDRYSDRALQLLVFNGFAQHMVEKLAEPHDDGSYYAVLLDFMQVLEVREGYAKYGADAFFDKHGKVVKIVRGGKTFHPDDIEWEYVKFCFRSSLNTKVTAIDHLLGIHSTVANYLTTANREQLPVDHPLRRLIKPFTFRSVVINYAAAWALFWPKGMLHRGFALTEDGMNQVWDYGLKQFQFRTFPELVAHQNIDTLKIPFHEDGMDYWTVVHQFVSDYIDLYYSSDAEVTADASIQNFWDFLDKLPGSFPTLSLANLKDVLAQSIVWVSAMHNHLGTLAEYVSDPAFCGSAWVEGEAANRPGSAVRNALIMAATGFKQPSILEDFSHIMLDDRAKDVCHAFIDALDNLVDVIDARNQTREQKYMSFNPSTIEMAVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WBE4</accession>
    <name>A0A6G0WBE4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peptidase M14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_016646</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000265">
        <property type="protein sequence ID" value="KAF0724715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WBE4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020410"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000084">
        <property type="entry name" value="Carboxypeptidase B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057247">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF143">
        <property type="entry name" value="SLL0236 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00133">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026199577" description="Peptidase M14 domain-containing protein" evidence="11">
        <location>
            <begin position="25"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="12">
        <location>
            <begin position="72"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0724715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="382" mass="42034" checksum="33696FD6DD3CBD0F" modified="2020-08-12" version="1">MKLSFLSCALVALVASADDDFVRGQDGRLRSIEQDATIRSDAVTNRQCQLKNTGYLSALKAGSYAKSTFHKCFHTTAQIYEFVDALVAQNPKLLSKFAISKTFKGQTIYGYKLTKGNSKSLYFQAVQHAREWVAGSSLLYSLSSILDDISAGKSTAADQFDIYFVPLVNLDGYDITWSSDRYRRTSANQVDLNRNWPTPYKNPEPPAVGDEIYPGTKPFSEPETSGINNWLQSKRNELAGFIDVHTYAGLILFPYGDTNSTIGNGYDAKFNTLGLGLKSVMGSGYAQQSSHQLYLAYGVFPDWAWRNFTKPALTIEIVGTDFVAAASTIPARGLEVYKGINQFAKEVVKFNGAMVAATVDEKNVVEAATVQVETATVREILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WBL2</accession>
    <name>A0A6G0WBL2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helicase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_017470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000297">
        <property type="protein sequence ID" value="KAF0723695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WBL2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013244"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005114">
        <property type="entry name" value="Helicase_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37066">
        <property type="entry name" value="HELICASE-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37066:SF1">
        <property type="entry name" value="LNS2_PITP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03457">
        <property type="entry name" value="HA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase-associated" evidence="1">
        <location>
            <begin position="82"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="1">
        <location>
            <begin position="235"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0723695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="365" mass="42326" checksum="F2D7D6D33D92B42F" modified="2020-08-12" version="1">MSSSHAMFLEVVRIARDIQAHTSDYTNFPARFTVPSMAPWPSSLQGKTIHVAKVRKQYKDGTLPQDVVDTLDNLGFVWDAKQHNWDLRVAALKTYKEIHGSLLVPYEYTVPSEAPWAKDLWGCKLGVAVTNIRSRMEVLTPDRKASLDALEFVWDSHELTFDIKVLALETYKNLHGHIHVPFEFKVPDNDPAWPSRCWKLKLGRAVHDLRCRGDNLLPGRRKVLDSLGFVWDSHELNWDMKLHALRIFKKEFGSLLIPQDFVVPSVAPWPERIWKMKLGQAVTNMRFRVDTMSRERQAQLEEMGFIWDYPELRLEAKVLLDIKFDLQSIKKEVQERFMTMENTNADVDKKFPLPDDAIKTDNELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WBU6</accession>
    <name>A0A6G0WBU6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aminopeptidase P N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_016931</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000272">
        <property type="protein sequence ID" value="KAF0724390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WBU6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020728"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01085">
        <property type="entry name" value="APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000003">
        <property type="entry name" value="Xaa-pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000007">
        <property type="entry name" value="Xaa-Pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033740">
        <property type="entry name" value="Pept_M24B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032416">
        <property type="entry name" value="Peptidase_M24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050422">
        <property type="entry name" value="X-Pro_aminopeptidase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763:SF6">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16189">
        <property type="entry name" value="Creatinase_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16188">
        <property type="entry name" value="Peptidase_M24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase N-terminal" evidence="7">
        <location>
            <begin position="37"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24" evidence="6">
        <location>
            <begin position="329"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24 C-terminal" evidence="8">
        <location>
            <begin position="557"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0724390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="620" mass="67789" checksum="E7ABDFA65CE372D0" modified="2020-08-12" version="1">MTSTLEKIRRAFAGIAPRVLDAELRIHPAASSHARVSALLVESEDAHGSEYVSSRDMRRAFVSGFDGSAGTALITNDKALLWTDGRYFLQAENQLSKEWTLMRQAQKNVPTLEEWLETNLASGDALAIDPLLTSVSTARRLVQSATKANASVVCCEVGNNVVDQVWESQPAKVPSDLRVIGIAFSGTAVAEKLTNLRAEIEKKKATAVVLTALDDIAWLFNIRGSDVEFNPVVMSYALVTLSSATLFVDAKELTPEVLAHFGDHVQVKSYDSFVSELETYAKTAPGPILIDPMQCNVAVFSAIPLAVRKETPSIVLKQKAIKNAVEIHGMREAHIRDGAALVKFFSWLEETVAAGIPVNEVSADLKQQSFRREMEHFVSLSFGTISGSGPNGAIIHYHADDESKCGTITTDKMYLNDSGAQYLDGTTDVTRTVHLGQPTPYEIHCFTHVLKAHIALATAVFPDECDGVKLDAITRAPLWKAGLDYRHGTGHGVGAFLNVHEKGVLMSFKLNPTGLLISENMIVSNEPGYYEDGAFGIRIENLMVAVKADKLKTPFGPFCTFETITMCPIQQKLIDTSILTGDEKAWLNNYHETVRAKLTPLLESSPSALAYLRRETQPIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WDT5</accession>
    <name>A0A6G0WDT5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_016094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000242">
        <property type="protein sequence ID" value="KAF0725453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WDT5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013150"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0725453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="294" mass="32193" checksum="BE69470956BBB5CA" modified="2020-08-12" version="1">MAEIATALAYTSAFVTHAVASFCFMMAMSILLFPAYYKVHPAPCSSKPTTSTALIHAVDKANEDGEEDMDEVAYVEWIPKQTTLQEHSTMDWTCLPVAVAQLVSELDKHHWFGQDDQEIPQAIHISSGGPCDELHDACQAQQVCAVGICQLVEPWSAPTADQTPGNSSPCVIIQPSAQADTTPRREKSLYGANIQVGLAISTVDCADVFAIRVELACPDNGDGQLVATAMWCLTATIAEVENLRDAMQPDVDDSEMLLLYKFDTPDDLQTFFDAVTARPNWSDAPALRRFCQMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WEK4</accession>
    <name>A0A6G0WEK4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_015767</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000232">
        <property type="protein sequence ID" value="KAF0725802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WEK4"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0725802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="71" mass="8334" checksum="7EEE23507A89E4CE" modified="2020-08-12" version="1">MVFSMDKHRCHVKNHSNLFHVQAISPPNTENCSRMSTEDRFQTRVTPSAWPWLTKVWTQNMQDFLGGKNTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WER8</accession>
    <name>A0A6G0WER8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_015623</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000228">
        <property type="protein sequence ID" value="KAF0726036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WER8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011430"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47160:SF5">
        <property type="entry name" value="MULE TRANSPOSASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47160">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MULE transposase" evidence="2">
        <location>
            <begin position="171"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0726036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="444" mass="51209" checksum="9B473B4DC7765C50" modified="2020-08-12" version="1">MTRANITQRKITYRCSFYRSQKCKARLEYYSSTMDYDYDSMTPHTCFPRRPAETAEIESISSISVITAMKRAVDSYATSTAKSPEQIWETVRTQFYNQDKVIVHGLSKIQVVKRVHRARASHFGLSVHGRVEVPPLALTNVHSKPEDKIDRLVGWAHPQLITLLRYDNITLFLDGTFRCTPNGFTQCIVLMVFDCGTKLYVPVFYVLSTSKSYDAYWNALQYVNDTSGESLKPKEIVCDFEKSLVNAVCDRFSGVEVMGCFFHFKQACQRHMIKYRIPPGEVKIAMSSGVLDMLNVIEPDKVEKQGIKWVRRKIKESCDEGGLGYSKQKWSRFWKYFVKTWIHLYPPHLWTVHGVRMDAVARTNNPLERFNRELNSSFGTPHPSLPRFVQVIEEISRKYVKLREDIQRGLAAPPSRRLRMNLPRAVTLNENGSGESSEDIDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WH73</accession>
    <name>A0A6G0WH73_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_015163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000213">
        <property type="protein sequence ID" value="KAF0726535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WH73"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0726535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="465" mass="50298" checksum="FB7A917FEF6DB7F1" modified="2020-08-12" version="1">MRSSNITTITLFRNLSAFSYTICTTAQGNAESQSTKASKRTDCCHCCTNPQKTRHLEALAVHNRWATFIVFGLGDPHLLESGQGRQDGTTDPDGVLALWRSDNLDLHGGRSQSGQFLGHTFRDTRVHGGTAGQHDVAVQVLTDIDIALHDGREGAVVDTRSFLTDQGRLEQHFRGTETFVADDNDVTIGQFVTLFETRRFGSGLHFLVVVESDVGQLFLDVTHDFAFGGGGEGVTTFGQDLHHEVGQVATSQVQTDNSVGKSITFVDGHSVGDTITRVQHATSGTAGSVQRQHGLDVHVHGRHVEGFEHDLGHAFTVGLGVQRSFRQQHRVFFRGDTQFVVESVVPNLFHIVPVGHNTVFNRVLQGQDTTLGLSFITDIGILLVHANHDTRVLGATDNGRKDGTGGIVTGKTGLAHTGTVVYDKSLNIIVSHGDFALGLESKSKSGQPSHSLDQKSLAFLEKPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WI57</accession>
    <name>A0A6G0WI57_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Sugar transporter SWEET1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_015027</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SWEET sugar transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000205">
        <property type="protein sequence ID" value="KAF0726885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WI57"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004798"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051119">
        <property type="term" value="F:sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047664">
        <property type="entry name" value="SWEET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004316">
        <property type="entry name" value="SWEET_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10791">
        <property type="entry name" value="RAG1-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10791:SF30">
        <property type="entry name" value="SUGAR TRANSPORTER SWEET1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03083">
        <property type="entry name" value="MtN3_slv"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0726885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="23832" checksum="A55047F6ABFAC8BE" modified="2020-08-12" version="1">MIEETLTLQAAVVASRRLIPYAAVASSILFAVAPLHDIRRIRQSRNTLSLPFLPFFLYVVQSMMFLLYALATSNALLMFTTSLGSILGTFYVWSYYKHMNDKTSARKWFLGGGGLLFMLGVIATAFDAQDAALWIGIPGNAVMVMTAVSPLAKASHIVRTQDASSLPVGMSVMNAVAGGFWTIYGVLLDDILVTFPNAVSTIVGLIQVHAANLDAYESNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WI70</accession>
    <name>A0A6G0WI70_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kintoun</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Dynein assembly factor 2, axonemal homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_015028</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIH1 family. Kintoun subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000205">
        <property type="protein sequence ID" value="KAF0726886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WI70"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004800"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070286">
        <property type="term" value="P:axonemal dynein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060285">
        <property type="term" value="P:cilium-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03069">
        <property type="entry name" value="Kintoun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034727">
        <property type="entry name" value="Kintoun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050734">
        <property type="entry name" value="PIH1/Kintoun_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012981">
        <property type="entry name" value="PIH1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041442">
        <property type="entry name" value="PIH1D1/2/3_CS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22997">
        <property type="entry name" value="PIH1 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22997:SF0">
        <property type="entry name" value="PIH1 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08190">
        <property type="entry name" value="PIH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18201">
        <property type="entry name" value="PIH1_CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIH1 N-terminal" evidence="5">
        <location>
            <begin position="54"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="PIH1D1/2/3 CS-like" evidence="6">
        <location>
            <begin position="269"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="367"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0726886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="776" mass="87754" checksum="1E6A80ADB6978A2C" modified="2020-08-12" version="1">MAGDASSPLETAFETACRERKEKFDMTEKEQQSFLKAMKDPEFRSLLNEYMQEISDPQHRAEQEMYLRQLENENKVPTDKQLVLPKPGFVVKTKYKQKKMFINICSSDKMQPPSSTRIAATTSTAAGTSWNLPYCVGPQRMEQDKGGQAVMTFDVCHHPQTLSRGMESAAFLKMLVNTSIDGVDKALLQLDPSAEKVAREYHILKGVVYKSGNPITMCISKPRETLASNATESQQPPSTTTKKPLIEEITSMPTEPKAAEQERPPVLRKISHQIVERGRFDLADHVESREAAPFRPRELVVKMPFPTHSSAAGIDLDVSSSEIKVTAKGYEPFELKLPYPVIESKGKAKFDKASKTLVVTLPVEPLPVPPPSTKCPQESLQLTEPDVQDEAKKEEDVETVAETEATKAEAPVDHSRWIERQDNQATDEFVAFREYALMRVHDKPPPRSFEEPPFTVQETATNLSYIIQVASIDPESISTSETDTSIMFEFQDGKKWFRFGIENASVAEWTYDLATNNMAIICRKCLIEEKSHSTLEPPVRIHEDTNAISILIDVASIDPETIKSAFTDHSCTIAFSTMQEKNDFEWTKTFSQSLAPNECKVECAQDNLLVILRLEKPEDEKTIELSEPTTSESPVVVPRFTNALIIFYFWMNLEEQLAHLQWRKVCNQSQIQGALKQTKQLHDKDVLLNATEGKNRAKWIKQVVQDEMTKPVEIPDVIVEAMSKETELENQALERSAAVHAASVASIQAKIREREQLVKRHKMFRKTKQKMLSSMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WIB6</accession>
    <name>A0A6G0WIB6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WD repeat-containing protein 54 beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_014947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000204">
        <property type="protein sequence ID" value="KAF0726957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WIB6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004378"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049546">
        <property type="entry name" value="WDR54_beta_prop"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21031">
        <property type="entry name" value="WDR54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WD repeat-containing protein 54 beta-propeller" evidence="1">
        <location>
            <begin position="55"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0726957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="332" mass="35935" checksum="8CC2626FCFD9FB1C" modified="2020-08-12" version="1">MWETKPEVVDAELSASLLANNLSVNKDTMVFAHLEDVVVVNPKSSGKKCNRITLVEKSIVYQALVCELGGEVYLAIATESGCQIWDVLGEHLHYSLSLAKELATIQDVQAHFCRGICHDDKSIFVGSSASTIFTLTLEAGQSKGQSEFAVHSTSAASIHAEPIHALSTPQDQAKATLLCSGDDEGTFVVWSIENAPNMEVKHKIRATGYPATTLKCISSDWCLSGDTTGKLRLINLRGGYVAADVGAHSRNLSALDANDNRVVTVGEDGYLHVWKLSEKGSEDQLKISLLHSHRVGDELLTATSKSGNANKTTLQRQSVARFTRQSVHYVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WK38</accession>
    <name>A0A6G0WK38_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_014422</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="VJMJ01000193">
        <property type="protein sequence ID" value="KAF0727595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WK38"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000339">
        <property type="entry name" value="Serine/threonine-protein kinase SRPK-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000770">
        <property type="entry name" value="SRSF protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="108"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="264"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="275"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0727595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="695" mass="79042" checksum="14C8359D2FF63C5D" modified="2020-08-12" version="1">MSAPGGGEVREKKPVAPTKWKQAAKAKGGVKKDKAPMPCLEEDDTEDDVASSPSHSTTNAPNDDDGASESPSSDDEESSSESEEEEETSYKTGGYHRVQVGDVFNQRFTVLEKLGWGHFSTVWRCRDAETGNQVAMKVQKSASHYMEAARDEVELLECVNKAASRTGIAPRIVKLIASFEHTGPHGVHMCMVFEMLGDNLLTLIKRYDYKGIPLPLLKIITKQMLEGMAFLHDECEIIHTDLKPENVLLEAPLMKMPKFRSLRAQKELSPDEKKKLKKKLKKKKQKQNKKEQDDVVNQMEALQITTDEPSDPQLWSNFGSGVESVSMETSLPPLTEYLVNARESRGCPTPHEYAARIMLWLPEDEIVASFGSMRRIFRIKMALTKAMATPVKNSRHATCFSLKNYNFDASSLVKRLHHELLGQVDEGTSSNTTVWRLEFDARYLGGICQFLETAWPRLRFLNIARSAPYVIQGFHLPIDPPLPEYLLQGIYLPGDEELEARVLPVQNRVDSWQERILARLNAENDAIPDYQVRIADLGNACWTYKHFTQDIQTRQYRSPEVILGQNYDQSTDMWSMGCFVFELATGELLFDPKSGKSYSRDEDHLAQMIELLGRIPKNFAKSGKYSNDYFNSRGELRKIHNLKFWGLKDVLVEKYEFDTDEAEQFAAFLEPMLRFQPSKRATAEESLHHPWLNTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WK40</accession>
    <name>A0A6G0WK40_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rap-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_014452</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000193">
        <property type="protein sequence ID" value="KAF0727627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020678"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07440">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11210:FF:000001">
        <property type="entry name" value="Ral GTPase-activating protein subunit alpha-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027107">
        <property type="entry name" value="Tuberin/Ral-act_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063:SF11">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN CG5521-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02145">
        <property type="entry name" value="Rap_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="4">
        <location>
            <begin position="1363"/>
            <end position="1464"/>
        </location>
    </feature>
    <feature type="domain" description="Rap-GAP" evidence="3">
        <location>
            <begin position="1594"/>
            <end position="1810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="894"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="894"/>
            <end position="903"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0727627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1839" mass="206613" checksum="C739B690A0C84506" modified="2020-08-12" version="1">MQSGTNAATAIGTPTPPQLDVKKLSRFFAEDKPPRKRLAAALEFLKSSNAEQHELFWGEVAHGSMFFSVLHAYLTELETMYVVSERKGIMSQMRTKKFQTDDWIDIFEGLEVLIKSNKALLASGWQHNRFLQIFQKLLLEENLPYIKKYAFRCLALYSDILMDADFGLRNTAQLLGSATNLSSASPGDVNIGFGFSHLDLLSESIDFTPYASGNSNVMLPPRVYTVGSVVGWERGGQATLAEEPVDMLKYVMDLSLERSDNITDVDVQRFLFWCHVIMHSYMPLLYPKTCMDVGFKDKNDKMGFFHHCPGSFQRVMARWLYKLRSKPKFMDALWAHKEYVDVIMETLRQRFAYRDPELVLDGIKFYSHLCKGTQYIPPAMKENFHELHRAIIAHVSQVFHPSVQFDDPNIYIVGVELLDLLSQQPLHVHSFAVLRKAILATTDASFFLRETPPGQSILMPMVATVYHTWIHGMVQPNGSSVDVWIELATMVKKWLTNPSVSAPFALEIIRRWKLEIKSVSSILQWYYTPNGIEKDELPKDISSFMSQQVAPTVDNALLILDRLLHVLSPATIGALRPPYLQAVQESVLEIVTMWTDKAPVLAISPSTIVSLFGEWFLPACETIAPEFEKSQCVALQTLCLVFTVKCNAEVLPMHIALLCRILHGALHDTTRFNILSTILNHASTIFGRSLPGIHILVPVFLHAIDALTEHHTTRLVRYGPEMKKNCLSAVQLLYGMITLPGKYPNLALESWQAKISHIAPGKAQGVPLLAEFDDELHDVAGRCFQRLLAFDASDGTDVQQKALWGLYLLIVLQLQTKPTILVKTYVVLLCDTCASQDPVLSQTALHAIHALHYYHEALHFYEPGLVQHIVLALSLLVQQQVEIASTAIRDNLEKTDSLPRAESPKTPSTPDVRKRANSWSAPEKQSPRRSSSNGDVSRPGTFSEGSDLKTISAKSSAIFEGLTDWVMGCTTLLEDEAVLKLLFQAMEAALIGSIPTQSEWQKVVEAARRKQRKLDTPLLFLGLAMRASLDPDRHKTSLQCFADIAAGAEGFLLHLLHHLHGFPSPAGIDQFVSTCTEFDDKENEGVTSFSFVYLNSIVMTVIGSVDACSARLVARDITGTYTWDAIALSNSMPEPQLAELNAVDVGQEEPWERSKELLNATRERLEVIMDPTVAHANLPTTDMCNICGGRVLKDKNAAAAEKSAGDKGTPSSSSALIPFPVAKKAVLKGNALPSMPLYVFHEEAYPGLGNGNYDIYLCQCNQAPSKQVETSKPAQVPICQLFSIEDNHEYIGSLDNERCLLDLLVDSIPMHYRDCGGDLIDKTLLGGRYTMQKYLDMEWEEFKTNRRVGPMHKDPSTEPGFTFLQRLLHDEECYSYLKTFLVKENGKELIEFCDAIKKFERSFEGNDRLSQANSIFWEYLSSESTFSIKFPYGICSNIQRAIQEAKSHNATLSLLLFQQALDYVEEKCFENGGRLDRFIASLNEAHMKSQQTPTNDANWSNFQIPPQLMLYDAFNVMELNVRICAETLLVKKADEALSPREPLPSNSKLVPSRLAPLDMCRLFLGQIGILPNGVLASHYQVHLLDNGVKLERSLKHLDKAPSRETMKIGVVYVGANQSTQQEIFSNTKGSTEYQHFLADLGWEIELATHRGFVGGLDANPKSLSNGTKTIYYSTSTSELIFHVVTMMPTKESDPQQIDKKRHVGNDYVHIVWSDNFRAYNQTTITSNFNFVQVVIYPLKHPSYDGLYLIEILTKPNVPLFGPLMTGMIVSRANLPDLIRQTVMNANRVCRQQTQWYMAPYTTRRKLIEEVVERYATDYSEKSMLTSLFKIPSPSEGHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WK41</accession>
    <name>A0A6G0WK41_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AN1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_014457</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000193">
        <property type="protein sequence ID" value="KAF0727632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WK41"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020683"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050652">
        <property type="entry name" value="AN1_A20_ZnFinger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10634">
        <property type="entry name" value="AN1-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10634:SF67">
        <property type="entry name" value="AN1-TYPE ZINC FINGER PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AN1-type" evidence="6">
        <location>
            <begin position="121"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0727632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="187" mass="20347" checksum="D5A0974B78A1909E" modified="2020-08-12" version="1">MAPPWLLRQGHFPFVALCASSGGDFEKPAARTIMQNTSGILPTSSSSANAPANPEPQPVQSVVPAEAAEPVARRIPVVAASPRVSKTTQTDSVVTPLDVAATVAALVPEPEKKTTVNPVTQTNKRRCWTCKQKIALSAVTCRCGYTFCNRHRYAEEHNCVFDFKNVAKRKLEEENPRVVPLKVARIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WKG5</accession>
    <name>A0A6G0WKG5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_014283</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000189">
        <property type="protein sequence ID" value="KAF0727769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WKG5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020624"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048685">
        <property type="entry name" value="COG3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048320">
        <property type="entry name" value="COG3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007265">
        <property type="entry name" value="COG_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13302">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13302:SF8">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20671">
        <property type="entry name" value="COG3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04136">
        <property type="entry name" value="COG3_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 3 N-terminal" evidence="9">
        <location>
            <begin position="62"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 3 N-terminal" evidence="9">
        <location>
            <begin position="176"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 3 C-terminal" evidence="10">
        <location>
            <begin position="255"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0727769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="748" mass="83482" checksum="560166C7C3D13099" modified="2020-08-12" version="1">MKLSSTQEALLARLEQAVGGTSREPSECSKAPLSLKQYYALQVPATPLQTKPLVLPSQVQQFLTNAQECYKACETVEQHTTKSLGLLQEMEDRHVSVTSLTSALYESFETLLKELEALNLKVRTIEAPLPYFTRLPTIAKAVGGKIDFSSKVESNGTSKVSIHVRPYSFGSIDPTSAAFEQSIHDIDECVAYLEQHMEFKDTPMYLTAYGELMVHALHTLRDYAITKLETARDHALASISKHPTAPQSEIDDASVSYIQFHLAAPACQAITKRMDQRETAPGNESFLPDVLDTYVSLRTQLLSPVVSSYLSVVNQTADIVNLLRIGCQYMVRLCEAEFRLFGHVFGVVPTATVLQIEGQEENTFERLIFQLSYTLYNTVRPRMLQQHTLEVLCEIVEVLRSEVIETQIHPRGHAAEALEPVIERMIADAQERLILCTQKFIQDEIQDFAPSRADLNYPERLQAPSVYVTWYPTLEHTLTCLSKVYRYVHMHIFEELAQDAVRMCTASLKMASADITVEKGHLDGGLFLIKHLLTLRERIAPFDIQFAVTEKNLDFSSTTDAMGSLFNGNILTDALTLSLENSILGLFTHGIPQVNTTTSDVKKDLEQELKKSCTVFIEHAVQHAAAPLVSFLQKVAPSPSFCLIVVKVYAARKSPPTPPPAPVGISAIIAMLKQAAAQLASQLPLVQEKIHAYLMNPSTESILFRPIQKGLSDLMDQVKALLDKEYTQEDRAACETDIQAVRHCFEHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WL43</accession>
    <name>A0A6G0WL43_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Elicitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_014112</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Induces local and distal defense responses (incompatible hypersensitive reaction) in plants from the solanaceae and cruciferae families. Elicits leaf necrosis and causes the accumulation of pathogenesis-related proteins. Might interact with the lipidic molecules of the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the elicitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000184">
        <property type="protein sequence ID" value="KAF0728006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WL43"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003293"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052040">
        <property type="term" value="P:symbiont-mediated perturbation of host programmed cell death"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.239.10">
        <property type="entry name" value="Elicitin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002200">
        <property type="entry name" value="Elicitin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036470">
        <property type="entry name" value="Elicitin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00964">
        <property type="entry name" value="Elicitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48647">
        <property type="entry name" value="Fungal elicitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6" id="KW-0928">Hypersensitive response elicitation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026118982" description="Elicitin" evidence="8">
        <location>
            <begin position="16"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="116"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0728006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="163" mass="16381" checksum="375614E2AF30EFFD" modified="2020-08-12" version="1">MKFIALVSIASVVAQAPAPCTQKQAGVVVAAVNASTNLAECTKDSGFNWLTFFTTDAIPTDAQATASLASMSCLALVGEASGLKLQPCQLWSNDLSKLVTQDPVAWIKAKSSAVSNSTSSTAAPNSSSNSTTTTTSAPTTTPKSSASGVVAGLAAIVIALVMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WLF4</accession>
    <name>A0A6G0WLF4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_013958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000181">
        <property type="protein sequence ID" value="KAF0728132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WLF4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018795"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="170"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0728132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="224" mass="25307" checksum="B4F344AEA2E3EBA8" modified="2020-08-12" version="1">MLGGRVLRHVRRLTTKIDKPETKPTSLFLQRDETLTTRIMGSDWADRRGQPVTFSMKLYWTIFGLVIANGVYAHYTGQDEFAVYDNVKKSLFGQPETKEHEFVGAAEQKAAAEETVKQPQPEENKVVQAVELPAKLEPAAGPMANHKATTPPVFGLLSRAPSPARPVLTKEQLISELAALRQQEKESRLELKRGSHRDMDVIATEIREIELLKAELKRRIKKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WM44</accession>
    <name>A0A6G0WM44_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histone-lysine N-methyltransferase, H3 lysine-79 specific</fullName>
            <ecNumber evidence="1">2.1.1.360</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Histone H3-K79 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_013730</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60328"/>
            <dbReference type="Rhea" id="RHEA-COMP:15549"/>
            <dbReference type="Rhea" id="RHEA-COMP:15552"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.360"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.360" evidence="1"/>
    <dbReference type="EMBL" id="VJMJ01000178">
        <property type="protein sequence ID" value="KAF0728365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WM44"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006729"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140956">
        <property type="term" value="F:histone H3K79 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025789">
        <property type="entry name" value="DOT1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030445">
        <property type="entry name" value="H3-K79_meTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21451:SF19">
        <property type="entry name" value="ACTIVATED IN BLOCKED UNFOLDED PROTEIN RESPONSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21451">
        <property type="entry name" value="HISTONE H3 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08123">
        <property type="entry name" value="DOT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DOT1" evidence="6">
        <location>
            <begin position="115"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0728365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="283" mass="32084" checksum="775F8C13EEF92E2D" modified="2020-08-12" version="1">MGDLNKLRALVESAGESVQAKILYIAGFLHRHGMITGIGKALLKEMLFQKDVRGPKLIERLSTATDEAWLKYIHRLIDVETLKLFDSLYMDYPLEHGKAISRQEREEQDLLTEKSLIYGEVDYLAFLHTLRKIPIEPHWTFVDLGSGTGRAVFVARLNFDFAKCTGIEILSGLHAAAAEVCANYNEFVRSVISTSTKPLEAAFFHSSLLDLDWSRADVVFANSTCFDSELIWEIADKAVALRSKAYLITFTKPLPDDAPFDIIDKERRNMSWGPATVYIHQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WN98</accession>
    <name>A0A6G0WN98_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="8">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_013407</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="8"/>
    <dbReference type="EMBL" id="VJMJ01000172">
        <property type="protein sequence ID" value="KAF0728838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WN98"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001234"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000097">
        <property type="entry name" value="Serine hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000586">
        <property type="entry name" value="PRK00011.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF35">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="9">
        <location>
            <begin position="13"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0728838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="466" mass="51212" checksum="20655520D95FCFB4" modified="2020-08-12" version="1">MVATDFPAGNTPLEHQDPELFNLIEHEKNRQWKCLELIASENFTSRAVMDCLGSCLTNKYAEGYPSQRYYGGNEVIDKIEKLCQDRALQAYGLNPEEWGVNVQPYSGSPANFAVYTALLRPHDRIMGLDLPSGGHLTHGFYTYSKAENTRKAVSATSVYFESLPYRVHPETGLIDFDKLAESAALFKPAMIVCGGSAYPRDWDYASFRKIADDNGSLLLCDMAHYSGLVATGEHASPFEFCDVVTTTTHKSLRGPRAGMIFYRKDARGFENKINQAVFPGLQGGPHEHQIAAIATQLKEVMTPEFKEYAKQVKANCHALASALMEKGYVLATGGTENHLLLWDLRPVGLTGSKMEKLCDEVCITLNKNAVLGDRSALSPGGVRVGTPALTSRGFKEADFVQVAEFLHRAAQLCVEIQATTGKKISDFNAALASHAGVKQLRADVNAFATTFNMPGFDVAAMRYKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WNN2</accession>
    <name>A0A6G0WNN2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_013259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000170">
        <property type="protein sequence ID" value="KAF0728957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WNN2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019423"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019424"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="310"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="455"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="525"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="599"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0728957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1183" mass="134305" checksum="63A6989D1DED684B" modified="2020-08-12" version="1">MQDIDDNDGDEDIDAKMILDLLEHKDQLIQDLQDEKTILLEQLESALWDLEIAKTAQSADSATSEDPSGEMQIARRVEGTIESSQFKGLEERGQSRRNEELTLVREHAQELEKRLESMVRVNEQLMNQLRSMNYCETCETETQTLEHAAEKPAQVRCLSQCDSIDAGIQTENGVKITILVDTSVQCSGNSLSIDEEHGETLQTLSAITTQWEIAQADHAARIAAYETQVQALQTQLTETNHRLLTSETECITLVSSLHAATEKLHQVEMQSRSALAQLEEEHAADILEWKTKHEHQNRLLDEKTLDTCHREKLEAIVNERETEVRQTQEDLHAALKQSHVLQLQLDSMVALQRASDELQAQLEQRLALVTQFPPKKTELLAPCIQHASIPWNIEPDHMCSWVVHAQTWQKQVLQGQVELANTRTEVDQMKAAHEAALSAIQVEKMGEIDSIRHSYEEQMTQNREMEHMIAQLREEGSRMRENVRRKQDLIQHYKNTIETNQAAFEEEKLKLKQKLRKESNLIKANQEDNARNQRLQRQVQDLQAEIQQVKAEKDNAIRRCAAMQITIKSLKDKLEKLEVPAKTPENCPDEFDGDKDQLVKQLKRRLSQKQAVVDALKAKERIRDNERIILEEKYERLHSKMKKLEATPQEDVEKISSMTMLDGLRACVYDVAFHVLFVQDNTAPPTEESNQNSPDAIPSMDVITSIGFTSQDVETLLKNRKRHRDGPDSRKRRQLLLNQLEHALEESPDNCRTILLDVMTTKPIEFQEACHLSHRWCIFGPRLILIPDQKMRDATPPQSSLFVDQLAHIVSEPSKPLLELAQAKLGLSKQKAAIFPQRSVLPAGFWSRVAHPPFSPSTATTSLSVDKEYDVIVPQPAEESFVKPESARMPMVLSYHSDTESSYVESDAAFPELPEPEQDVELDQTDEAVVEDSFAQFVDAPSDPKAEVERLTKQNEFLVLMLRKVTAKIVLNRQDMAAYKARIAQLETPPPKIITSEIATQTDDDETESNPSDTQKIDTLTWQLKIAHAKIDALAANLHQERARLEVAVAESAACAAQFDLEAAQWNARFAAHEGEMKVQQVALLRYEHIHAVMQDYFKGMGIEIENTMDANAVAATIHSKPLRQSDVNQVDAIFNHVTESMARELAFLAELNKLDPTNTAACDQLYQRSCKKQAKKPSVRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WNP4</accession>
    <name>A0A6G0WNP4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BRO1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_013253</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000170">
        <property type="protein sequence ID" value="KAF0728950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WNP4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019430"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0728950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="36059" checksum="DA6088F8E0EF5C2D" modified="2020-08-12" version="1">MKHLDMLWFAEMPQPAEWTPPKSLSGEPMVEIAARRGRIKSKLAEVLPSTNQGRDDTVDLKPLEDSLTTYLQLLEIHQNVVNSTVEANQPLPWKHSSIPQSVPLSLSWISMERGMIALCLACISALLAEKRDPSVVCVRDVWRKAAGYLNLAASFLPHHLGVHSTVQVWMHLCIVYAHTAEMSNVENAEECNDQIARYHSALSRSAHSECLAAHSYLSNFSSSYILGQQLRWLLLASTCLCKITFWWNEVELYAKRPQVALVLCNAILKTKLPMPPQYPHRSNVLYTKVMQSMVASHHEALKLAMDYKSANLMQVEKDGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WP10</accession>
    <name>A0A6G0WP10_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4419 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_013239</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000169">
        <property type="protein sequence ID" value="KAF0729103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WP10"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012137"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025533">
        <property type="entry name" value="DUF4419"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31252">
        <property type="entry name" value="DUF4419 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31252:SF11">
        <property type="entry name" value="DUF4419 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14388">
        <property type="entry name" value="DUF4419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0729103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="361" mass="40624" checksum="99218542D51A1857" modified="2020-08-12" version="1">MTTFAVSPVQVDKYRRKLCKQNDDMLTRLKEFKKEGCKEILQATPIKGAFVPTNSAFVLGAIEAYNQHHNLVIRPDDVWLAIMIQFGFFVNGNAETLREALVKHQGQKELTVTEFGSLYTVDYGKMAAEMIGKMEEHLVDPSLGEWILPSFSTTTDHDRIVGSVVMMASMKKYFKYKFELCCGIPNVTLLGTVQDWETIRSRVDYLKRFGGHMVEWVEMLSGVIDQFVASAKGAVDVDFWQRICHNIGGGSGPRYISGWISVFCVFDEEGHWQGSTKSVTNWGRVTESEFPIINTNDIPAGYLTVDVLIDDNGAEHKSLMFAGHMSYQVEDKKTIIPTLSWAIVLKNGEVPSDSSMDERFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WPR7</accession>
    <name>A0A6G0WPR7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_012899</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000164">
        <property type="protein sequence ID" value="KAF0729397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WPR7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021411"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0729397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="29610" checksum="FC1DDDB9705DEC1D" modified="2020-08-12" version="1">MDDRTVPTTDEAKRLTETMRKREYRAGKRDEFFELLVESRPSHCKECEPPGLWDKVNKSQYLSIVLCHWAYINETPQKDLAHQPTYTTLLTHPITRKQGLQWLSERIYHEACLVLPETTLYRGKVEDTISQNTYVSHDIDEDGPTIAAMETIYQHTISTNFEIVARYYWENATGDAAPVPWTLIDKVDNGRFMYLHHTNARVGTNALAIAGLFIEANRAVITNCFVAKDELLPLGEGLQRPHGMDCVPSRDARHHIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WQZ0</accession>
    <name>A0A6G0WQZ0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_012701</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="VJMJ01000161">
        <property type="protein sequence ID" value="KAF0729813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019209"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021341"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021670"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054465">
        <property type="entry name" value="Integrase_p58-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22938">
        <property type="entry name" value="Integrase_p58_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="9">
        <location>
            <begin position="582"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="10">
        <location>
            <begin position="1191"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="454"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="994"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="456"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="469"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="995"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1012"/>
            <end position="1022"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0729813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1608" mass="182430" checksum="924EC96261FAEFDB" modified="2020-08-12" version="1">MDSTCDFPDDEYTKEIEDRLYPIPKSDIRKQLDQIRKRYINPSHEELLRTLDLSAADSHLLLAPADIEDESVWTKWFADTLEKCDEARRASRDFKTHPLARISSTQGNPYSVLDMDESHGDGMPTDAVDSDDTFEDGDFSKFELPLYVTGPSGYACANAQTRQSAITHYWTELPLTDHLSDSASAKTIAQFKARQQRCLHRRSGARVDPTYCSDLLHGNPPSTRLLSRMSRVCHTRGRSETDPFIQAYVENFKATTLIDTGPSCSFISAALWQKLGCPSLSQPKFAFVSADNSNLEMLGRIKLSIKLVGRTVQFPFWVMSTALTDCIVGIDLLRYLGAVINLNDNTLSIDGCDELISLTRLDPASSMNHLGGNVTVVAQTIIQPRSFQWVSCHTHKSLPISTSVLVEPHRSQSALLHVASALYRTTSSRTVMVEVANPSDSPSYLDQHTSIGTWMSVPDESSTSTTPPDDSKQDAPTDEPGRVLTQMGGPGVVCPVQSQANTTKEIPIDWTDSSLSTDQRELLRKTLMKFADMFVDSSKAPGRTHLVEFSIDTGDSPPIRSVPYRTSKAEGDIMEAELNQYLDLGLIRPSKSPWSSPVLMIRKPDGSIRFCIDYRKLNSVTVKDSYPMPRIDDLLDVLGRAKLFSTMDIASGYWNVPMAKDSIEKTAFTCKYGLYEWLVMPFGLCNAVPCFERLMEHILIDYKWRTCLVYLDDCIVYSEDFGSHLVRLSQVLTKFREAGFKLKMSKCKWGRSSVPFLGHIVTPAGILPNPEKIKSVLRIKTLKDASEVRAFLGLAGYFRRFVRDFSKIAAPLTLLLTEEKFTWTPACNESLEKLKRSLVSPPILAHPDFDLPFAIWVDASHIAVGAVLMQKQNGKNRVIAYASQSLSKAQQKWISKEMGISEIECWGVVWATRKFRPYIDRRHFDIYTDHEALTWLFNTGSRSGNHKLARWAMEIQGLDYTVIHKPGELNGAADGLSRLAVCPIQTRSMRRLNSTTTGLTTPPTMNVRNDDESPGLDQDNENDNQLNRKPPVQGTPIELFDRRGRPTPRLYNEQANDPWIVALRAFLEEGAIPLDPHLQNLVVRNSHQYVMQRGIVCRYVTIKTPLRNPELVVVPVIPHTLVEEVLYASHASSLAGHLGLMKTRERIRRTAYWLNWQSDCKEYVSKCPDCNRAKGGRPWKQGPMQRMPIYSLRGPFGLVVVDALGPLPTTNRGHKYILVFADYFTRWVEAFPVPDLKTSTFARVFIDEVLCRFGIPDKLLTDRGSNFVSELATTMYTTLGIHKLASAPYHPQGQGLVERFNHTIVQMLKIFVNDHQTDWDTYLPRLLFAYRTAHHETLGDSPYFCLFGRDPTLPLDLAFLNSDPAWKSDDLPQYKRRLASSWKQTRKLVEEQLIQGQNKSAIAKSEQRPVSFDEQSAVWVYKYFSKSSDPDDHRTPKLATHWHGPYRVERKMGPNTYKIAIPTHPDKVVTVNVDRLKPFRGYYSRPYNEETPEDESPLEELTLDCLPRSSFIDRVDFGDGDVAYTSVDSPIHKIVDKRRLPNSREPDYLVQHVDGYQYWMKASKLADYRTYIDVFENEQRIEKGLPPLRRSRRFSEMDVEPQPSTLYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WRE2</accession>
    <name>A0A6G0WRE2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Restriction endonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_012432</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000157">
        <property type="protein sequence ID" value="KAF0730034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WRE2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018324"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0730034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="28670" checksum="ABF6AF5D83039539" modified="2020-08-12" version="1">MMDDPILNAPTVDEYGDPSWGPVVLCHCITWKEFERLLKHNEGRIRRWAFEPLEDGTDNGQVVIYSLPTETHERTAHRVYRSIMRQICRAGNDHDLDDSLFCGSPTCTIGDLGQEADLALTPVGLSVGGPILQSSRGFAFPNVVVEIAYKNDSLPRLRAKLARWMSDETSVQVAIGIKIFPTSLNRTAILRLRGPPAQVTHVAFGAPRPGPLQIVFPLALVYTGVNLPASLAGAADAEISIDLIQLRTWIDRFVEEEEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WS53</accession>
    <name>A0A6G0WS53_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_012264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000155">
        <property type="protein sequence ID" value="KAF0730262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WS53"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009435"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0730262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="480" mass="54391" checksum="A0C283C757DFBC51" modified="2020-08-12" version="1">MSMGEDDGETQTTLQDTMPTQPQSQQLSSEDGLMRRMSLLKKRDGVSPSNGDELRMDDRELSEGDLARDFFVDCGTHTFPYGESYQMDPNLPSEEDVDAQREICDNVEDWANSLLGTVDDLLAWKDQMVALHGLPTNAISGLVMLSSRFCRCKGQLQIALSKLLAMSHQLIGNLLLNSHILQYKTNMIDMSVAMDNEKMVLAEEQCKLRAALAQITRMKASHRFFRWCRLSSRLREKELRQEMEQQTSHFEAKRNEFHHVVKGQREQIQRLTEQVTNLQTFKSATDTLHTKIVLMPATQQVQAKAARLKSAPVRSVPFEKPLNPPPTPTDRKRDPKNPNDPPTKWSKRDQQQPPSNQSTDSTKPVVVEANRIVKPPATARPSTSGATPRRQRIPAEALDLKSPQDMSARQRESHYKEAWEERRAKQRVESEQKHLTSAKLEHPETNEATCFELDGDKVLVAGHANALVNSLGLRREKPKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WSM5</accession>
    <name>A0A6G0WSM5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_012131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000154">
        <property type="protein sequence ID" value="KAF0730431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WSM5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015959"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0730431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="462" mass="51944" checksum="E50286D7AC693B57" modified="2020-08-12" version="1">MCDVPVGTMTGTLPGVFYSSTGSCGVNVQEFFVHETSMWLMVFVATGPVNITTLVQMENRNPASTKGNLILSTAFFKAYFPNDIYLVLHQQAQIVQALIANETKISIVQFIRRGSELSLSMFALFNETEPDFDFFSWLYLFDWVQGQREVVSFEGDNSKVALISSSTPFTRVQANPAETPTNVAYLMRWFMQYITWVLLFVACIVCIYILRVRGHVKGSNMVSFTRVASLVWLGRPLIFVRAIAALCLLSTSTLVLERPLNGLVSHLTTAPQPWYTITLAAGELNWIVYIINDIFSVVTNEYTQMYSFLCYLAVWVASAILVCSVAQVDFQVECHSGTVVIGSLRQLLLLLGLVLGLCTLCYTIVRVWSRKLWSKQTKSLLLYAAARHQFRTTNWEYNDMVFLDKASAVLTGLLSIEIGDTLYVFDVKTWRLHGCLLHKTTFDKGDCPTHLLHAVPLVDLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WTJ1</accession>
    <name>A0A6G0WTJ1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phospholipase/carboxylesterase/thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_011867</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000151">
        <property type="protein sequence ID" value="KAF0730758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WTJ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010370"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF17">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="3">
        <location>
            <begin position="42"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0730758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="194" mass="21717" checksum="1CDBB030D56D53A7" modified="2020-08-12" version="1">MQLPQTAFASFRAPHSLPFDLGYTWIEPALNEHGDVISHSTDNSKRLESLSDIVDQWMEALRVLQEMYNWPPQRIFLMGFGHGGSVALHVATQCPSRLGGIVSISGALFDTSTTVDTQKTPVLILHSVNDPLIPQAMFAKTKRTLGENVTTKSMPYYPIRLSNKEEMSAVMKFFDETLYLRNLALEAQADVVEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WU72</accession>
    <name>A0A6G0WU72_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_011565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000147">
        <property type="protein sequence ID" value="KAF0731013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WU72"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017117"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="509"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="549"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="573"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0731013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="723" mass="82626" checksum="1405C641CF40E466" modified="2020-08-12" version="1">MSSEGIVMAAVTDELDTDHPDQLKTPEVKFALMDDDQLNVEIDVVRQESTEEGHHKAPNYVSDPAELVLQACAVPKGQSMPETIRLKKVKDYMVDQFGMMQEQVGMNPNTLQFDSIVPGSNPPVKYEVGYLEWAQESSLTRVRLCFAVGLLFLAAFSIYEAHNELYTVRTGIPKDSPFSKIDSTTSGILYGVVFGLGLGPFAIGYILLGQKWAARHLETITFWVFALVALSMIFKKPLQQQAGPVLPLMILIIPIFGITRMRFIHSCVLGWSIFFLYLIVQLVSLSMIHSIPSINWKYDNFSDILYQTVNYGIAIIGGMVSHYRQELTRRRNYALKLPFAGLADDENPVDFSADMYSESKLYDQWTLAFRNLEVEEYFCRVWYVIDPQPYENPNRGDIHENVYWNIRYAVLGICLNQLVLAIQDVKLLLMKHFYFEYGMAAIMRFAIVMPCYLAAFYFLYLLGKKFWQVFLRRGLSQIELQAVEALEKPSRIKTKWVTSKGGYVRPAQVFSVVVVSIHVCAMMILLLQVGKAFIQNHSDKQPKATKPNVYFMGVLNAILFAHRSGFKVRFVYAFRTTSFMIMLFIFFSSHNLHFSPWEYLWLEYSGYLVCTQLLGMMISHEEESLRRNFFVLKSIRQLEFEKWFAGVLLIQKGVRKFLTRHKSRKLAKEASGQTIAVKPAPPSTKPVTHAQAFLARASYLGCQAQMIQIAIVLFEVIYSAATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WUF2</accession>
    <name>A0A6G0WUF2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Membralin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_011639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000147">
        <property type="protein sequence ID" value="KAF0731093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WUF2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000621"/>
    <dbReference type="OrthoDB" id="6779347at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904294">
        <property type="term" value="P:positive regulation of ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019144">
        <property type="entry name" value="Membralin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21650:SF4">
        <property type="entry name" value="MEMBRALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21650">
        <property type="entry name" value="MEMBRALIN/KINETOCHORE PROTEIN NUF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09746">
        <property type="entry name" value="Membralin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0731093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="417" mass="47931" checksum="C8DFF5E4DB2787F2" modified="2020-08-12" version="1">MESEWSPLLILKLQQVNAEIQMEQIFFRMHVRVSRMLSRIAGGKTRIALETALFVAATTMLALMLVLHLNFVSPSGQAGCFAQYMPAALPPLIRVDIEPDPTWIHPMGHVLSRILNKQNRNSFVFAAHKGLMALLEYPNGTDHTMPVVQVSIPLSSDCFGVQHLGHSPIWSVFLDKVVGFDTILINQFIALADGKGFLRNEFSKDTYNLNYASEFQSTTATIYSRAAFKVGVFFTILFLFFSTTTLVSFILRETQQRMLRFTLALQHHIRHRMPYVKLVFSHIIESLVFVPIMVGMLFFLFEFFKDRLLAFMVMSLVWLCELYSVICVRTWLSLTFFPALFLSYFAMFHIYFFCFPFGFSYIALWTTTTFLLQVMLFFLNRFELPALRDGVISAQVPRQFVLTPVEQYGSGTSRRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WUQ4</accession>
    <name>A0A6G0WUQ4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Autophagy-related protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_011501</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)</text>
            <dbReference type="Rhea" id="RHEA:38663"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)</text>
            <dbReference type="Rhea" id="RHEA:38895"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Preautophagosomal structure membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATG2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000146">
        <property type="protein sequence ID" value="KAF0731241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011598"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061908">
        <property type="term" value="C:phagophore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026849">
        <property type="entry name" value="ATG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13190">
        <property type="entry name" value="AUTOPHAGY-RELATED 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13190:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13329">
        <property type="entry name" value="ATG2_CAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="109"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1170"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1262"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1374"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1262"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="1381"/>
            <end position="1390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0731241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1857" mass="207857" checksum="F90C4E02F124EDD3" modified="2020-08-12" version="1">MFFSLTALTDPALKRLYKFVLKRVLGRFLQHELDLSQLQVHLRQGTLHLVELELHADAINEMLAASGLPFQMKRGFLGSVKVTVSYTNLLHESCLVAIEDVDLVLEPTTTIPSSSSGPVPSKASPQSTSAPSQPTSTTPTAATNEYEVDAVSQEGLDFVATWIERVTSKIKVTVSNLCITLEDSTSCPVALMIRVPWIELVDETPQEAYPSTSVLKGIKWKGLRVEIVHLNRDSLEEDSTPFSVVPLLVCDTTRPSYLQLKLSPSMVEVDLFVPLMEILVQPKQVGQLAQLVDLFTRPTPQTSTSNSAMSSSMYMSICDPQQAATWCPPEDDGGDDQAFPLSLTEFQRIERLLQQYQQNKPTLQRMSSAESVESAGLSDIDDEMFHDCEEPMMAQSMYMSARQPTEESSMLQRVKIHFLDIEATMLYEDLVDEEAIADGLPDVSKMERLVWRIHDGVVQAIIHDPHPKNLHISLHHVSCEERLVPRLSVNDDEGAELSNPWLRFLGDEKDVVIHLQLDPLGHSSCIIHAQPLQVEVDLFMINRLQAFFATSTSSFSTSSKRTTEETSPSSPPMQFEVHFPFVHVHVRFPLIPSDRIRFGPSSRRGLAEDVLQIHFEHVKLSTSTMAWDQFHLELHYPPNFNPHCEERLVALICSSNSQAQCSWSVQTPTMEQLQEAAHVKANMKETFGSDAEQGEVSTADGLDAWRQTELLEKACIMASLTVARLHIPEATVVVDKPIYDRLMILTDALFTINPVDITGLAKVTTIQQCNMSMEIMCDAFHVALRNENVPAYRLELEHVRIFSLSGWLGSLTSRLHVVAQELTLFEGATPVLYKIAWGRPHEGPMLLFLQETTELAEDMRDISLQLHFSHPTWRYDMSSNWLGDCLNVLLTTYPPAIVPLDTPNSDVFDATQTPIPLAMPIKTVFTKLVVQCYQAVLDYAPPDITSRALLVIGKLCLSSNLVTDAAVQGYKVSVNELGLFVHPFRMEPNVYVLEDSWLDKSRPRELLSMQETIENLGFLQVSTLDFADVFVRVSDDQMNLELCLGTIKLKVCFDSCETMCLVFTTWWEEFAKNSPPEEKPAPIPIEVADIAPQQTVPPLNILDQIDFHMFEPSSSTMRDTEARILKAQVQEAKKPPVKRAPSAPLVIEDFFGEDKPQESSSPWFISNSSMTEHAAASSPADRVESPALQEASARWIPPEPNDSLKVASSFKAVVDDDDYDDDDTYDETTDMTMSVSINDTEEVELDLNLDGDMRSELNRLLEEDDPGAMTEDEELSPRSSSVLSPPESPTTNENSARWYNENHLNEPPAIYLHHVEIPIAGAAAALSFGEKELASAIQTMTNECPNMKTPVMVKSILLRDFNVEMRLFGGHDWNPVTPSSTVPPPPPPTSASPSQNNTKQSLLDALLENYVDESEKLMKEKPKSRPSKHRKTEEMLELRLSNIKLRLDLYAEATPQPLAQNTVLHVGDVEILDYISTSQIRKLLCYWKSDTLHPRETGTPLFHFHLMTVRSSATEEHRLKLKFLPLRINLDQDVLDFLKQFSQTSTPAPAKPPVFETKPDVPTALPAPTVISEKQEVTASSSVYFFQSVDIRSFKIKIDYRPQRVDFQALQAGDYLEVINLFVLEGMELSLRHIKLSGVDGWDALINQTLIHWVQDISRHQIHKCLASVVPMRSITNIGAGAADLILLPMAQYGKDRRVVRGLRKGATSFLRSVTIETLNTASKLARGTKSLLETADHVMHDSKKKKTHFNSRKGNTHARYLMSQPANATEGLNQAYASISRELHVVAKTIVAVPLLEYQRTGSHGYVKSVIRAVPVAVLRPMIGATEAVSRALIGVRNAVDPEMKEDMENKFKDMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WW59</accession>
    <name>A0A6G0WW59_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_011084</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000140">
        <property type="protein sequence ID" value="KAF0731783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WW59"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003062"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003063"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026161973" evidence="2">
        <location>
            <begin position="22"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0731783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="379" mass="42686" checksum="39A5190AFE312591" modified="2020-08-12" version="1">MQKTMLRCCLAVLTYVALVLGLPAKIQWRTTQEASYEPRWKEEDLDVEAPQVETTSTTSKTSDEAMNIDASVEEEKIATMESEAKCNDNSDDKEKEDVFVDSQQNSIKEDSKTLKSRETIATIVKTRQKAMMDRISKARRACATLKNQADNDRASIYALTEQILKAFKEEALKEEVVKANEESIKASNCEENEDPLDNPNVCLQTWTNSTRVLGQLKQRHEEVQDCAEVAGQFDSLRQDQTQTRQEDMGPPVDKTNSQANSSGPDHASSFSEIATTEKEDVKTTTDKKEKNDVTSGKTAVSASKRVQGDYGDHQDQNANKQRVMATRSKKSMGSPSSPCMRFLERVAMTRCLFTSWPLVPQKAWDHHPRLASVFWSERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WW89</accession>
    <name>A0A6G0WW89_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TATA-binding protein interacting (TIP20) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_011046</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAND family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000140">
        <property type="protein sequence ID" value="KAF0731744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WW89"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004551"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010265">
        <property type="term" value="P:SCF complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039852">
        <property type="entry name" value="CAND1/CAND2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013932">
        <property type="entry name" value="TATA-bd_TIP120"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12696">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08623">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25782">
        <property type="entry name" value="TPR_CAND1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="TATA-binding protein interacting (TIP20)" evidence="5">
        <location>
            <begin position="1041"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="316"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="317"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0731744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1219" mass="133793" checksum="21CE19A054C5DAE3" modified="2020-08-12" version="1">MKGNTNSFVALLEKTTDFDKDERYMATSDLCNELQHDVELGPDLERKICAAVLKQLDDKSNDVQSIAVKCLGILVTKVQEKQVGDICEKLCDLILNGKPELRDIYSIGLKTILTDVSTKTGASVSTALCGRLLVGIAQYSDQAVKSDTLDILTELLKRFGHDFTGEHVAIMDLLLKELKDERAFVRKRVTACLGALGVVASDALLHRLVEHLLSSVKQEGDSNEVRTLIQTIGTLSRAVGHRLGRHLPTIVPLFLKFCGSTDDESMQNDASNELRENCFQGLEAFVLRCHAEITPHTTDILAVAMSFAKYDPNYMYGDEDMEDDEDDEEQYSDADDNDYSDDDDASWKVRRAALRVVSAIIGTRHELLEMIYNQYSESLILRFKEREESVRVDVFGVVSDMLRATVVLQPAEKATRPVFMRQRSCIDQLHSRVGTIMNAANKQLGPKTSVATRCAVFAMLRELAKVEQGQLGPYLDLLMPNVLKALEDRNSSLKLDAILFLRLLLTSHEPQLFQKHLKTIVPLAVANAKEDWYKIVAKALQLIGSLVNVIRPTDTAPLADNVAIFVSPLYDAVLPRLQAYDIDQEIKDNAIASMGLIIATLGDKLTTALPIVLPLIQERMQNEITRIAAMKSLGVIARSKLNLDLSIILSDAVTCLAQLLRQQSRTLKQTALDTLIALVVSKGSSIPLPILCETVREAAGLISDSDLQLSQLALNLVLHTIEASPAVGQDAALTAKALPNALILAASPLLQGQALEALFSFFGQLVTMDHHGFDSLFHELYDASRPDATKHALHNVARCVAAICVKSSAASQKKAFDLFVKDISSGDVAKKHVALFCLGEFGRQTNIESLGDVRALILGCFQSGVSEEVKQAAAFALGSVCIGNMNVYLPTILEELTKGAHVYLLLSALKEVLSSKNTLLGQYVSAILPVLNTHCESEEEGVRNMVAECLGKLALINPALILPSVTKYCEASTPVKTRWTAVTCLKYCMACGPDAEPMRHLTVQPILNALQDEDLGVHRAALLTLNSAAHHQSAFLKPHVRDSIIPLLLKTMEIKLERVVDLGPFKHKVDDGLVLRKGAYSCFDTLLDTLPSEVDVGAFAPYLLKGLEDHDDVQTLSHQILVKLTVVAPGSVLSNLDVLCTVLEKTLNRRPKDTQVGSEVDRINDVIRSALRAVNATASIRDADSNPKWKVLMEKIKKTENLSVMLEAISIERGVVSEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WYE9</accession>
    <name>A0A6G0WYE9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_010291</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000130">
        <property type="protein sequence ID" value="KAF0732583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WYE9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004421"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0732583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="123" mass="13373" checksum="1EAFF0B3CE018730" modified="2020-08-12" version="1">MASRARCASNIPRVCTVAHHVLIDQFLEEVEAQPNRLGLAVGCSGSRDLYGALIVNEHIDGSFAVSAAAVNSTSVVLWPTRLCLFDIFAVMLVVRKVGVTERVWSCVSLSVILDAKMLRPFQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WYI7</accession>
    <name>A0A6G0WYI7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TLDc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_010374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000130">
        <property type="protein sequence ID" value="KAF0732667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WYI7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020155"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354">
        <property type="entry name" value="NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="1">
        <location>
            <begin position="300"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0732667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="462" mass="51783" checksum="545E1F2A55706E51" modified="2020-08-12" version="1">MLNPQRIQSHGKPEVTLTFTKKPLGIGLVPSTQLYGAWEVGHAPKEFPELEIGDVLLAVNENASVNRMDVSSFRAFIARLPCPLTITFRKPRLYGHCDSHTTATALFPQSFEYTQFMRGSTRHGRASALQWKQSLAHEDSKTKLPAKGYSSIGDIVYTFKSKAIGIEFAPSTRLYGSLEIESIDSKDVEAILHPGDVLLALNDSVAAKWTHSDLEHHLQTTTAPFKMTFRNPRLHLQYLRRHFEAPNLASTSVSRAMFPATNEYKKLQSTGPEVASRNEWHTAHAKLRQNNWLAYYDKSVILKKNHVHILSAALPPHVQCSNWKLLFTTQSHGFNMTTFYHRTQDKGPTIVAIKDSTGQVFGAFSPSSLRHTRQVYGNGRTFVFKHSTIYSWSGIDTNFIYGGPNRSIIWGGGTSGLALCLELDEGRGFTQPCLTFDSPPLTEPPEFECWAVEVWGFEGLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WYK3</accession>
    <name>A0A6G0WYK3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_010340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000130">
        <property type="protein sequence ID" value="KAF0732632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WYK3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021020"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="615"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="718"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="245"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="326"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="659"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0732632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="754" mass="83245" checksum="AB24D0ABE3FBFE8B" modified="2020-08-12" version="1">MPERYSRRLAGLGVEYSGLEDPKATTTHDQATASSAQTEVYPADLTDLPQDADDTTEGSPPSPDRKRPSDESPTISPPTERAPPKRPLLPQETPAITYPDRDELVRFQPSPILAPAPSFITTTPIVELEESPASSPSASNNELWPLALRLLHSQVQQAATIQQELQNRQAQLLIENSQLAREHAALIEHARLLEDTRNNDFRTIASQLQERYDRGTSAFQRELEAKYQEVCEVLQRDRVASNLQIQEATTTITDLNKQLQAAREQLALQSSAERTAAQVDQIRLQEVQTLNAGLMRSRSENPDLIRRLQLATEQTNLSGNDLERARLTWTQERETLEAENQRTSEELSACYTLLDESRMQMAQMREELARAVEHASLTPSGPCPTCATLKAQLSEERALHSKEVADLMDDNRALQEREHESAEQRISGLQKELDRLRTEGSSRNHEFEARAQNLQRQQAELQNTLAMVRQATASSDASYERAVEEQRRLQEAQERLKQEEQAIAAARAALSSDRASCLQQTILRGDPIQTVTNPYSSPSPYAPRGPLPTVNVVPIPYSPFAPTSAAYGSPQPSIKMVHPIGPTSVTDTAYTIPPPITATATYGYPYPATYPLSGAHPGGSNKMGPDPGPGGGGGSPHPNPPNPPSYLHTNMTTPDPGARSRTAIATTARTRLQTPTDPRTLKTHPRHPIVDRPRVSTPIRNPPRPVVTIGVSYAARKATGGPIALRTRSRNKRSPSSNEEPPPVPRFEYRGTLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WYN2</accession>
    <name>A0A6G0WYN2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_010369</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000130">
        <property type="protein sequence ID" value="KAF0732662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WYN2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004869"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="371"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="46"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0732662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="395" mass="45536" checksum="AE8A6792F48392FF" modified="2020-08-12" version="1">MTSPVHLLPRGRSWGEDMQIYKTSKAVLPWRPEQQTPVRHITRYEKSREEREYDLIRAQYRDVKREAATKAKEMKDQMAALADAKVKQSQFVPKFNIINHSSSEAESVDNMPRPPNTRVGYNIVNHVNLDVPPVQVAPSSPLGKKMVNSRHLARPFSVISNKYHSNHDARFEEELTRAKETATTKFLETHDFNPLLVRYYDHEKENTFLLERQARQKIHGVDRDDKLPHGEQYCASRLYNLVNHTVLRPEKFEMVSNVGNRRLNVIKSTQINKEIHKRAEALDERTMLRALNRISHARNDQTYVHGYDPITNQPFDGRLRKARVPVRTQPKPKAWNRVERPTRAVEPLPAIESTPVSALRPIQPEILYISHDTPIDPGGASVAPAAMNNQRSSDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WYR3</accession>
    <name>A0A6G0WYR3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CBM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_010344</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000130">
        <property type="protein sequence ID" value="KAF0732636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WYR3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003972"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026020659" description="CBM1 domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="4">
        <location>
            <begin position="216"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0732636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="254" mass="26361" checksum="8AC2FF60AF53514A" modified="2020-08-12" version="1">MFTSIATVLFAVASTVYGHGQLADPAAEFKPGTTDVTAFCDTMNGPKVLPGDNYNNSPQYNSAAFTAHFKNSSYATLKDLVKANGGTCGACGTSVATATPKAFPSDGTVKWNHGATEGFSPSHTGPCEVWCDTTRVYQNDDCAANIPDGNLPVSPSLCHGASQLTFYWLALHNPDWQIYLACVPLKSSGGTTPSSQPPVSTSARPTPSTSAPSNGGSVPVYGQCGGQGYTGPTNCASGNVCKQYSPYYSQCVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WZP5</accession>
    <name>A0A6G0WZP5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_010081</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Folate-biopterin transporter (TC 2.A.71) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000127">
        <property type="protein sequence ID" value="KAF0732976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WZP5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021708"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039309">
        <property type="entry name" value="BT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585">
        <property type="entry name" value="FOLATE-BIOPTERIN TRANSPORTER 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585:SF5">
        <property type="entry name" value="RNA-BINDING S4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03092">
        <property type="entry name" value="BT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="519"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="561"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0732976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="608" mass="67665" checksum="E42D4E3B075090AB" modified="2020-08-12" version="1">MKQATATVKGNNTLVTTRERAGYNRSIELIIRFSSRRSRMPQGGELEERLSYRLSGQVVDDKGDYVGAKSPSELEDGAIMEGGALHLFSREAMGLFSQYFAIGVLYGMIPALKYPIYNVYLGMEPYQVSTYAVLVNMGWSFKVFFGMLTDCIPIFGYRRKPWMLIGWIVAIVCLITMISMSIGEPYCNRATTDSCGKPFAKVNATDLAANYNLDAPNKGSTFIMLSILVSFGYVCADVAADAMVVQYAQREPVAIRGRVQTAIYVVRYIGSSLAVCVTAFGLNGVKYGGSFSFSMAPTVPYGLCLIPCVMVMFTTIFVVVEKKSAGSRFVDWWVVFWQLLQQRVMWQICAFRFMNNVFNNMSTTADNGIATYWAHVEPINDSLQQLLAKVIFGVILVIVGKWGLNWNWRWIIATTSLAVVFIDMIVQFLVTWDVVRNQWFYTGVALSENIPDGVRFIVSAYCAVEIADPGNEGATYGLVTTVSNLASPFASVIYKYINSYLKLTTNDFKTDSTEVRWDVTYAFIIAYCCKVFALVFLFMLPPQKKEMQELKRTGGKSKLAGALLVIIFIAALSFSMTSSIMSIFPSTKCYRIAGGNGKLDPNTGKCPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WZW0</accession>
    <name>A0A6G0WZW0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_009929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000126">
        <property type="protein sequence ID" value="KAF0733107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WZW0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011241"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0733107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="349" mass="38818" checksum="AEFCFEEF23DDA1D5" modified="2020-08-12" version="1">MEKRSRRSSIVSQLHGERCGSFPTVAESNCLIRHETKRSLDMDAIHLHELQLVKLTNALNDMTLRLKSLQHQVDALPGRIWQTLDSHDGTTNADIVKGALKMLLETISTPSTTTQTSPAVSKRPQRSPTPQPESSPSAGNVSKALGRQSLDATSQWRAKRKRAESPEAMRSLPVSPRPTLSTPRAPEERPRCHPDASQYQVHATSTPRQPSKANADILLQLASRLSSASQVEKTPPRRSSISIKSEPTGETASPSGNKFMIYQPTDRQFFNTPPFSYQPSPTTSPLVEELPSPAHERIKIEHSPIPAREVEERRSERESPTPAEANRSLQPEELEDNQDTPQPRQIQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X042</accession>
    <name>A0A6G0X042_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_009960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000126">
        <property type="protein sequence ID" value="KAF0733139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X042"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021313"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0733139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="145" mass="16675" checksum="1E6879C7ED2A6BBD" modified="2020-08-12" version="1">MTTLPTTRALPVSVCSRCGGRSEHFGPNVTYDGMNFCAKPGCPRRQVCAFRCVKHNRSFDMDPTKVRVYRFCHICRVDALALGEADVNLHQYIVPNVEIFITRLRWIPLPLPNPSPTVPPVRLVFKRKRRKGAFKRSKLRYSFKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X0N1</accession>
    <name>A0A6G0X0N1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_009638</name>
        <name evidence="3" type="ORF">Ae201684_009641</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000122">
        <property type="protein sequence ID" value="KAF0733391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VJMJ01000122">
        <property type="protein sequence ID" value="KAF0733394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X0N1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009080"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="14"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0733391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0733394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="244" mass="28173" checksum="7B780098E03B1759" modified="2020-08-12" version="1">MTSQAAYQALVDIIARLRDELRAYARAVLSLVDENHQLEQQVDTLKGQLDKAQEEIQDAKMEIEIWCEFRDGIHQEIATAHDHIHTLETQAQVDRAAWHAKEQSLLDRIQVLEMELHISKAKTTGSSVVQPKTTQTHKRRVEAVRAAYQTRVMADNRHNKTTQDDLSRRTDETFYEMFAETHVVTASHKQAMDAIPPHKTYPEDTPVVAHVNQAHVSPAETWLDRIRRWIGVLQKTWRFGLLFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X1F9</accession>
    <name>A0A6G0X1F9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_009563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000121">
        <property type="protein sequence ID" value="KAF0733632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X1F9"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0733632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="138" mass="14392" checksum="BB2630370E05651E" modified="2020-08-12" version="1">MAEFEPNAAEPESPALEAPLDILKEPPEGAKPAEIATEPPAPEAPFPTIAVIEPPVPPVALPVEIDIPPELPPTEVLEDNDTPPEVPAVEEPLASVIEPPIGAAPAVNEIEPPVPTVPLPTIPERLPPDPPLDIAEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X1T5</accession>
    <name>A0A6G0X1T5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <ecNumber evidence="3">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ae201684_009326</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type-1 OGG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000119">
        <property type="protein sequence ID" value="KAF0733755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X1T5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000569"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034039">
        <property type="term" value="F:8-oxo-7,8-dihydroguanine DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1670.10:FF:000005">
        <property type="entry name" value="N-glycosylase/DNA lyase OGG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012904">
        <property type="entry name" value="OGG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052054">
        <property type="entry name" value="Oxidative_DNA_repair_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242">
        <property type="entry name" value="8-OXOGUANINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242:SF2">
        <property type="entry name" value="N-GLYCOSYLASE_DNA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07934">
        <property type="entry name" value="OGG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="13">
        <location>
            <begin position="125"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="310"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="315"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="331"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF0733755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="357" mass="39995" checksum="6DA319BF4B3E2A56" modified="2020-08-12" version="1">MWRRLCPRSELSCEVTLHCGQSFAWKKLQDQWIGVIGRHVIALKECPTTDAVHYMCLHPQGTTGEKAALDVDAHVRDYFRTETNLVKLYELWKAPNDKFSQAFVALPGLRTLRQDPVECLFSFICSSNNNISRIQQLVDKLRINYGDSLLKTQEAEWFAFPTVSQLKAIDESELRSLGFGYRAQFIVKSAEILHELGGPEYLEGLRANPDPAEVQTALQQFAGVGRKVADCVALFSLDKLEAIPVDTHVWQIACRDFRFNKAASKSLTPSVYAAVGKLYQDRFTPYAGWAHSILFAADLVHFKALVAPKDASKTPSKKAKPAAATKKSKAKAVDEQIDPKDEAPTPSRPKRRRTKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X2G1</accession>
    <name>A0A6G0X2G1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_009151</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000118">
        <property type="protein sequence ID" value="KAF0733974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X2G1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013661"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006560">
        <property type="entry name" value="AWS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050777">
        <property type="entry name" value="SET2_Histone-Lys_MeTrsfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22884">
        <property type="entry name" value="SET DOMAIN PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51215">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AWS" evidence="10">
        <location>
            <begin position="30"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="8">
        <location>
            <begin position="77"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="9">
        <location>
            <begin position="201"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0733974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="535" mass="60928" checksum="B5C3481142DB82AE" modified="2020-08-12" version="1">MTTEDISHAPVYEAIDKNDYLFKHRMIDITDLDFCTCTDRCGNDCMNRITYMECYQAWNCKLGRSCGNRSLQTLEAPETLVFQTVNRGHGLKSVVFIPKGSTIVEYIGEVINQAMKIDRLAEQAKANEANCYMVELAEGVFIDSRRKGNKSRFISHSCMPNCEMVKVDVGPVARLAIVAKEDIVEGTELTYDYQVITNDIEGFECKCGSIQCRGFMTWNSRRGSQRQLWDDDDVELELEGLLSELENPCVRFPPNSTNAKCADEDEELVDMSLSTNDNTMAKQLPHVCYNMGSFEDVQVKFGLFCGTAPTNGHCLFVAMDACIHDIRHVGVGFKGNLLDEAAGDRIMAQRAELWCSVVSNQDAHWYASQEFVTNLVEKKKLNVVDAVDELFSQRAKYHPRTTLPKHLWGHSSDVFCFRKIVDRDIYVFSEDPKRLAWCLSVYLQRTAKKSQKLKYVNDQVPVEQWQSLFKAMPDAYFLVNKANCHWEPVFRKTQDVISVYLLLKSESRKSSSRSNCVGVDARFVFCKSLLHTDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X2Y9</accession>
    <name>A0A6G0X2Y9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_009124</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000117">
        <property type="protein sequence ID" value="KAF0734263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X2Y9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006431"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="entry name" value="Sodium:dicarboxylate symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42865">
        <property type="entry name" value="PROTON/GLUTAMATE-ASPARTATE SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42865:SF7">
        <property type="entry name" value="PROTON_GLUTAMATE-ASPARTATE SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00173">
        <property type="entry name" value="EDTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="Proton glutamate symport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0769">Symport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0734263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="450" mass="48738" checksum="8276874222720328" modified="2020-08-12" version="1">MVHLQLQQDAPPKEPKTLTRRILTSLTFWIIVGTALGILLGSEAPDFSKKAAPTANLFLRPVQFIVFPLVFSTLIVGIAGNNDLKSLGRVVLKSFIYFEIVTTIALILGLLSVNWVKPGGSGFATVKNPNVSTADKFTYALWINHLAPKTWGEMMGGSGSSELLQVLVAAVLFGTSTAMANDRAKKQIIDVAEAVMWVMFKFVDIVIWTAPLGVCFSVANAIASNGGLHVLSSLGKLIATLYGTLLVFIIVVFGPVFLYLRMNPLEFIRGMREPLIIAYTTATSEAALPKVFEALDAFGVSKHITAFVVPFGYSFNLDGSTLYLTLGAMFCAQAAGIHKSVGEQITMVLMLIVSSKGVAGVRSASIIVIASTLDQFDIPAWTVGLLLGADWFMDMARTFTNVFGNCLAAVVVAKMEGEFRKEGWNDPQILDIETPREGFEEVSAPYKPHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X4M0</accession>
    <name>A0A6G0X4M0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sec1 family domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_008637</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000106">
        <property type="protein sequence ID" value="KAF0734788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X4M0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001501"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="579"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="582"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="596"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0734788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="764" mass="84086" checksum="C5E3076A77313B61" modified="2020-08-12" version="1">MPSGINLTDAILGPLADLCASEELKTCLVVADDGCVEALRWSGGLAFLLESVQVQSVMSWHQVVTAVCSPPKQSFDLETTTIAHLFDPWMTGKKHKVLLLTSRPFAEMEPVLAALIREDVASQFVVATAIPEKAHALTFDTARTRLLRNTSGNDHQVRIVYLPLLYAPLLDAKAETHPSLFVLTHPECAPVFPLMRSQLKQSEEHAWKHVRDVAPQDIPERSRKAFKCLAQVLGGMIMQWQVEVKDRIFALGATSLKVGHTLQHFLDQLQEECTMTELKELKPATLILVDRTCDLATPSSHQYTLLDRILQQLPPATTTDPATSKADHITEVSPLYSTPSPTPFGAASAIPPECTPSSFLSAVTWAGGVSICHAQAGTASNRVFESLATMAPIAALKHLDKELKEVAMDLLKQKLTPVPEKKNQPRGRDVILRWIKCISDCVDAKITWQHQELLQIGIAVLETLERMESSDMAWKQLVGVEKDFASRNEYPEWIVPGLVEWLAGQNAYESSVDLALAFQLCIYAFALSGDRPMEPHTKKTFIDAIKTTILQSVPHRLVPREIERSGGSDSDVVVVNEKAGQDDDWDDWEEEEGETSSSPSQNEPNSSLSQSTQQALDEFVAKIFPTLEECGQLYFELPGSPETTGLLPRLISLLTDESHPSIPHLQHVTDASEQLTKAGMDLLKSGLSVFGFGGQETMLHAAAATKTAHCKPNEATIVFVIGGMTLHEMQSISQVLQTRRPDLHVVVGSTTITNPEKIRAHLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X4W1</accession>
    <name>A0A6G0X4W1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin-related protein 2/3 complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_008539</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ARPC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000103">
        <property type="protein sequence ID" value="KAF0734877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X4W1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003410"/>
    <dbReference type="OrthoDB" id="200404at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1760.10">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007204">
        <property type="entry name" value="ARPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036753">
        <property type="entry name" value="ARPC3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12391">
        <property type="entry name" value="ARP2/3 COMPLEX 21 KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04062">
        <property type="entry name" value="P21-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016315">
        <property type="entry name" value="ARP2/3_P21-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69060">
        <property type="entry name" value="Arp2/3 complex 21 kDa subunit ARPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0734877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="174" mass="19363" checksum="347E63E392F0036A" modified="2020-08-12" version="1">MPAYHSAFNDVQCSEACGFSLLPLKSRSRGPAPPCPDDQEDIADEILSLFRANVLFTNFEIKGNADRVLVYGTLFTHMCLKRLERCATKADAQRALATIAADSFAVPGESSFPLGGMVKVAANAAETETIRGYLKQLREAVAMRLIELVFADGTKSKWWMFFAKRKFMNKEMLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X7N0</accession>
    <name>A0A6G0X7N0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_007896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000093">
        <property type="protein sequence ID" value="KAF0735894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X7N0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018661"/>
    <dbReference type="OrthoDB" id="149075at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0735894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="166" mass="18680" checksum="3FED4BAED2228C48" modified="2020-08-12" version="1">MCLCRGCLCPPHALRLTHIKRDWHDPLILTNLVYVLAAIVSFALGQNTCGILQLGASIASSLFHRHRETKYLPLDACISGNLGLIALYLAYHAHLNDLHHVLGIKFIMGFICAFTFIYCGMPGDIQYDLWHRHWHFASGSTTLVTSVLLSIYIPHFDLLLYNSVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X7S7</accession>
    <name>A0A6G0X7S7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_007659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000090">
        <property type="protein sequence ID" value="KAF0736073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X7S7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003530"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005742"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0736073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="742" mass="84317" checksum="618C49371211467E" modified="2020-08-12" version="1">MESDWDFLDGLPFLAMPAGDGQPLSPASTAKSRKKKQSPPSDDSGTSPSEERPKTIRHERRRRDEIQLLRDQVSQLEAQIPAMSKSHIPTAWERRAMNERREMNKAMVENQHLRQDVEQHQLFIQHLQNVLRKKPRLSAETPPEEWQLYKLPADEFMRTRAMHAIADRQLQRMDNAFLRAKLVDLTEDVSWARPSGANRLETASRLVLPAHYRVVSAAAWDVFRGVTTSEAIDGVTDTTQMVDAFLAYNTVTDTRFGDVLCRANVVQKYYPAVESDVIVTHSIVEDALISQDGDIVEQKWSWIQLVPLGPDICEVTFLVQWEMLDEGDNATSDEDVLANMMEKVSIALRPTGTSIPEVSQHDDGVQQLSLKRQFFAERSLRFQKTLKGAINSAIREYSEPKKRGVGAANSGRRKDAAKAAQKQDATSDLSAWKRMAKVERMEKGKAIKENEELREAVAGHATFIESMQKVFEKKPRLEYQFDIYSVEWKAYKLAAEKSLRVAAIHAMADRQYDRMDSAFIRAGLIDQTQDLFRAQFLPQPNGTTVYELVNCVSVAAPFRLLGASIWQAFSSLKSTSCPRDFIETLEIIDPFTVYSRKQMLAKGDAKVAWQSNIIRKYFPENDRCVFVARTVLEDELSPPKPTDVVEDKWIWMEVVPVDLCRCRLIALVQANFGVLPVLNKPSDCTNDVVDLINGLSITEGPLEPSKFPRLPESQRKISSRFRSLTCRSSPKMRDIFMRFSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X8P3</accession>
    <name>A0A6G0X8P3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_007444</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X8P3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008943"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
        <property type="entry name" value="FYVE_like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43102:SF2">
        <property type="entry name" value="GAF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43102">
        <property type="entry name" value="SLR1143 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="33"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="162"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="202"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="227"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0736426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="457" mass="51424" checksum="D8658D1B0E2F898D" modified="2020-08-12" version="1">MPRASTTVVDIAKWNRLTLRRDHWVPRSHRVVCYVCSKPFSWFRFKHNCVMCGEVVCKTCLDKVHVEHIPSSPRRRSVHVSEGLTALVCIYCSLSEFNRSSAFHNDMRASLKGRYTTVSSPGVGGRLVSSDQQFGDTIRFPHQAASPRLDPDGTYLQTHLVLGPRQEPSRPAPTTHKSPRHHQSTAPPNRTSIPSFYPAKPPPRDFTQDNSHDENRKFQRKPPSGRHSISTFPTSLPTVSTPTHQSNRQAPHSTTQTTPGPPISAQDLLNESHRLKALASYNILNTPREEAFDVLASSASSLLGCPISAVTFIDHDSQWFKAAVNWPISSIPRSMSFCATILRRAEPLIVLDTTLDPRFKKHRFVTQAPYVRFFACAPILSHSGHMLGSILVADMTPHEDCKVHILEQLAHETMLLLERRESKFVLKVEEHQRMEDLFQALLGREYQGIAPSEASNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X989</accession>
    <name>A0A6G0X989_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Centrosomal protein of 70 kDa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_007557</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Directly interacts with tubulin-gamma; this interaction determines centrosomal localization.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X989"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006311"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070507">
        <property type="term" value="P:regulation of microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037692">
        <property type="entry name" value="CEP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14594">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 70 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14594:SF1">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 70 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0802">TPR repeat</keyword>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="12"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="161"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0736547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="616" mass="71081" checksum="100875917C65F376" modified="2020-08-12" version="1">MLPEKTSLINIVHDLISQLERQSQTVQDLIQESTINSKQQQRTEANLAASEKKLQEMRQSLDNAQREIESFKVDIKDVKVKFESDVKSLKNQKVKLEQQLKISEHRVKAKETLLERLQNKLQQQIDKEEFSKSRNQDVFRKIQQREPRKTSPSDLKSIELIGMYENERSHLNDEIAQLRNQVQELCSEVREKENIISRASGGGINIKDHDSLLHRLEQARFEQEQVTKQLRLQERSIHEKMKNIEAELQQSKQVIQELREENSNLHLEVEARPTIRDYKATQRRALLLERQLSSQTLAMKEANNIEELRKYIGTAELIRRDKTNAKLQLNRLNTLPKDTCVEIIQDICRQLELTDITLIGPSVAKMISVVQAIPRLEKFVRDVCTIAASKPASSLESVLHTLSRWKQNIGNLNTLQKYAADSFQILASRREKSFQPVESATVYSQALKAIKELVEFESQFLEEQNMYQLAAENVQKQPNLLVNRMVQHFRQLFGVKTMDGVFPKINEVFLFVNEMNNALASIKTTLGLAQDVSVSNALIALKDHLETVRPRPMPRQTENYVVAKNEEVAGLAQVRQNHMILKELKHVLGAQTFEELVPRAQRLMELLSISIQNTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X9P7</accession>
    <name>A0A6G0X9P7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_006950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000087">
        <property type="protein sequence ID" value="KAF0736791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X9P7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014715"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF317">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="431"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="468"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="515"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0736791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="561" mass="62001" checksum="5A309B5295FA6ADA" modified="2020-08-12" version="1">MWCCQPRSRLAFFWSMLPNEKTAVENEAEKWVFVVPYAPRRYCLPLCTLPFRRWMLLVASILVQMCNGSLYAWSILNPHIDEHIQDKARDSVPPAKELAVVTFYIAVGAHGFASALFGPFVERHGPRHSLIIAVCLHIVGHIVSFVSVYYKSYIGLYIGYGVFCGAGFGIGYIAPVSAILKWFPDLRGTAGGFAVCGVGLGAALWGNLYDPLIRSVGVDGVFLVHGAVLCFGLLLSAFVLRTPPPNYVVGGRNPHGIKVIDPPKQSVTSHIGLSTDSAERVSAVLGDIQQDNYVSVFDYREQELGEAEILYHNKIKNLCIRECAFSVDFAFLYLVFMAACAPGTILLSRVYSIGGDVYIDEGDENLVRLVMFMAFSDFLGHLLCPLISDGFIRMAQLNPAYGRKIIIGVLVVNQIVVLILLKSFIGDSKTFVPFEVVLCFLIFSYGGVFGIIPSLLTDMYGLYNSGTMHGIILTASSICAIGGGLTFQHYFFSIVSKFPEEKIVNGLNAAYEFNLRWLLVVACVGCALVPLVRTNPVDRFFPGYQYSLFGRPLIRIIKQDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XAR1</accession>
    <name>A0A6G0XAR1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Metalloendopeptidase</fullName>
            <ecNumber evidence="2">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_006391</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1 2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="2"/>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XAR1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011841"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF850">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 2" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="1 2" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026131717" description="Metalloendopeptidase" evidence="4">
        <location>
            <begin position="16"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="5">
        <location>
            <begin position="100"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="339"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="356"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0737212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="460" mass="51332" checksum="1A6B39AD9789DA6E" modified="2020-08-12" version="1">MKLGLIAALAGVALANDRCYDEDDKTHYRHGAISYKRGPPGYKGSIYAVCNDGEWECKVSDQVLDQEALPSVDCDQVITEYDIMMEQAANGDDRRLKEAGLMLNPKHAAVWPAGVVCYKLAPGVNETVLPYIKTTEEEYRKKTTVRIISEEQCKTSKIQSICGHCRNYALLDDKKPGCFAFVGYEGKPDQIMNLAPECYADGKPGRVEHEFGHAFGLFHEHAHPDRKIIIIESALATSRNNYVKKTDSEHTAYDTSSIMHYGATGGVCLPKDMTKRFCDINESHDKTGCVIPTLDDCDNEASKVLGQRDGLSPTDVKSIEFLYPKLSNEARSLDKLFAGGKSAQSDESDATKKSDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XAX5</accession>
    <name>A0A6G0XAX5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_006480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XAX5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010607"/>
    <dbReference type="OrthoDB" id="79341at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="63"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="7"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0737309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="102" mass="11688" checksum="83D33A65D3CB8F93" modified="2020-08-12" version="1">MDETEAATDKAKRYEALKKLYEALQADHVELSQRYAAVKQSISRVTNENEYLVDELCRFTESDFDSESDVGEPSEKRVKTEVAPNDYGNAQHERVKTEADVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XBF3</accession>
    <name>A0A6G0XBF3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_006646</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XBF3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014656"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF2">
        <property type="entry name" value="PROLYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="60"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0737486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="475" mass="52069" checksum="44F4F2E8E1F51494" modified="2020-08-12" version="1">MASTAIVHSGRVEKLPGGVCSIDHYIKAPLDHFSPSSREAITVYVREVFAEKFASNASLPLLVYLQGGPGFPSPRLTAPPSGWLKTALSEFRVLLLDQRGTGLSSPLTAQTCRHFADPAALAAYLTHFRADSIVHDVELFRKTLFPTQKLTLLGQSFGGFCNLSFLSFFPQSLERVIFTCGLAPVGATAQEVYEATYASVAERNRRYYARYPGDKLKVVAIVKHLMQHPAPLPSGGVLTARRFLTLGMPLGTVTGMETIHYLIESAWATHFHGQQADATSAPELSYAFHSTVGSMQSSFDTNPIYWFLHESIYCDGPTYSPSAWAAEAVHARTRVGGVAMFDPTRFDGLDGEALTEAVNAAPLYFSGEMVFSWMADDYAMLKPFKAAADILAQKSDWRPLYDQAKLRNIDIPSAALVSFDDLFVDRTLSLGTAALLGDTCRVFVSNEFQHGGLRDDPSIFEKLLKMTKGEIILPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XBJ9</accession>
    <name>A0A6G0XBJ9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Extradiol ring-cleavage dioxygenase class III enzyme subunit B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_006652</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XBJ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011416"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07363">
        <property type="entry name" value="45_DOPA_Dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014436">
        <property type="entry name" value="Extradiol_dOase_DODA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096:SF0">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006157">
        <property type="entry name" value="Doxgns_DODA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53213">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Extradiol ring-cleavage dioxygenase class III enzyme subunit B" evidence="6">
        <location>
            <begin position="55"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0737492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="279" mass="30414" checksum="8E5AF76406EBBDD1" modified="2020-08-12" version="1">MVNTAVCRVAPAVFVNHGGGPMPYLVTVTDPEQGPTRAFLENVASQWLGLNDPATKPAAIVLVTAHWEENVVTISSSEKHELLYDYYGFPPEAYNLKYDAPGSPSLAQKIKSLLTDASIPSQLNPTRGWDHGVFIPMKLIYPAADIPIVQVSLANSLDPDLHFRLGQALAPLRQENIAIVGSGMSFHSFRPTSQVKVQTKDFTDALNAASAKTSVEERGEALKAWKSFPHARACHPREEHLIPLHVVAGAAGEGSVTTYDIENPFWNNFVRSFGWGISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XBX3</accession>
    <name>A0A6G0XBX3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_006745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XBX3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015521"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000019">
        <property type="entry name" value="Nuclear inhibitor of protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015151">
        <property type="entry name" value="B-adaptin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050923">
        <property type="entry name" value="Cell_Proc_Reg/RNA_Proc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23308">
        <property type="entry name" value="NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09066">
        <property type="entry name" value="B2-adapt-app_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01020">
        <property type="entry name" value="B2-adapt-app_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="72"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0737590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="704" mass="77684" checksum="BEEB07C8F08C776C" modified="2020-08-12" version="1">MALQSELSMNDDFSQAAATAKANGSTVTTYATTFQPPNWIVMPIEASSAVRFEVMRVSKSCGVCELGKKLMSIFGREQDGSDFVLANPSISRKHAAVIHCAKGGVYLVDLMSRHGTFVGKTKIPPHDPFLLHEGDIVTFGQSCRTYVLKGADQNGPSQALKRTWPRLSLSSLFSHTLILRRTSPARKCSDLTTKMVAKICSGSYREDRVKEFIDQVSELDDEQLEEIAILLVEKVRQSYASAHHIVLALLHEKIAVQEFENNLGTIVQVSQTNLEARKILKTIAEARIENAPKTPTESEQEEPEGESSYAPPAVEAYAPPVVPYVPPMPPTQSSEVKSRERVLSDEGKRLFASAINGTSTVVDDEEEKENDNGHSEPPSSSFSFIGAQSAEPATSSAFGFMSKSNSEEEKSQASSEPPLASSSFLIDPSLDPEDFENLWQSAKSSEEWTVEVVSYFNTDLMERCLALYSHVKILASGKVGGVHKFYYYAEQASNGTIFMAEIQVIESMRELSATFKWIELGLLYDDGHLLFIKLFKECLEPCFIVDHPRLATLAQVQLSVPEPVAVSAEPAVPEDGSFAATLSSHPDLDIASFEALWLDATSISELEDPDERDVSGIDSVISQFQAKRLFCLASGSMDNEDKFFFYAEWTKRPWLFFVELSISRPDGALVALCKMYAPDATDEDHEVVAPLFVTLVEDILADLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XC14</accession>
    <name>A0A6G0XC14_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">26S proteasome non-ATPase regulatory subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_006307</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000083">
        <property type="protein sequence ID" value="KAF0737639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XC14"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007859"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019538">
        <property type="entry name" value="PSMD5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13554:SF10">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13554">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10508">
        <property type="entry name" value="Proteasom_PSMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0737639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="514" mass="56830" checksum="4539C7230F099FD6" modified="2020-08-12" version="1">MDTWSALSNFHARSVATAGNRESLLEKEMVRDFLQKVPIPNIFQCLQEASESGATKQVKLVCQCLERIFRSDIGADILFEEEILPFLVAGVSHNELDAKRLTLDMIDLHLTVDRHWNMDNDILLQVICDCLLDEDSGAARKAGDILFKLVSASGTGLYHKILSKIRAIQVEYLSRPSRDNSVEYVRLLELTSKCAGVNDVVMNDSISLGLLQPILDGIKSTDALFLLNFLDIIPNLCTTKTGLAFIFHSDLLSHLIESSTDPFVGGGALRLIGKFSNLAASHHMEAWNWAESARSFLAAAEMSIQSPDSQQQIAAMDALAVFASASDRELSALLAQKTLCESWLTLGKSSIMEVKSTCFCSLATILACNTRLVTTQIPGENATVWQYHRELLHALGAYSGRPSTMHHLMDCLRQPFEPIRVAVYTLLQAVAVQGHPWGVETLHGYGGLIEYLVDRTTEPSKSTREWKFAIVDALLASPFQHLLGARAVEELNKYFTQGPYAGRAKQADPMLESM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XCI1</accession>
    <name>A0A6G0XCI1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_005888</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0737891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XCI1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019548"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.10.10:FF:000007">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF29">
        <property type="entry name" value="PEPTIDASE A2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="8">
        <location>
            <begin position="114"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0737891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="425" mass="48251" checksum="CBEF36348408491E" modified="2020-08-12" version="1">MPRNGDTVLTQQVYPGVIASVTDERLSSSRHGKDTRAEIPINWDGSSLDLLQRETIRKLLLEFDIFVTTSKAPGRTDRTKCTINTGNAAPIKSAPYRVSQREGELMEAEIRQYEDLGLIRLSTSPWASPVLMIRKPDGSIRFCIDYRKLNDVTIKDRYPMPRVDDLLDVVGKSKYFSTMDVASSYWNVRMEEESIPKTAFVCKFGLYEWLVMPFGLCNAVPQFERRMEDVLRDQLWMSCLVYLDDVIVFSPDFATHISRLRDVLTCLQSAGFKLKMSKCHWGKTSVAFLGHIIVGGDLAKSGEEVRAFLGLAGYFRRFIQGFAGISRPLEKLKTAEVFEWTSECTDALENLKRKLVSPPILAYPIFEDPFFVMVDACPIAVGAVLMQRQDGRDRVLHLKFKKVKPTASLPLNLSSCLYSYTFLNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XCN3</accession>
    <name>A0A6G0XCN3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_006231</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="VJMJ01000081">
        <property type="protein sequence ID" value="KAF0737737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XCN3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002227"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF687">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="84"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="21"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0737737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="421" mass="47257" checksum="4B98410C4C4B9E91" modified="2020-08-12" version="1">MEPNVILFGDFTVEETKAVLGKPKVQAPEPKKPFSWSNLSKPQTPPQQTAPPKATTATQPLEAAFEQALLQLDLHECARDLQRRGFINQGNTCFQNVTFQALLACAPFRNLLCTLSSTVDLPPTSPPAPPLAGWKQLLLLLRELEEPTLAQQMKQSNKKTAITLSPHFIRLFQTAHGQQEDALEFLEFLLDHLHTEYEQSPCTFPLSRGHSQLAAAAADDGWAEIKKNGKASVVHHNIVENESPVTYLFKGTLRSEIQAGRKLGKSTIEPFHCLHLNMSKSYATTTLMQMIHDTMADEVLEQHMIKRTTFETLPVVLSLHVKRFTYDPVQGPLKINTFVSYPLELELPPSLFSPALEKTKAKYKLFSVISHHGQYAVGGHYTAVCCDAKDQWTLYDDDNVIHVTKQAALEENAYLLFYLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XDI6</accession>
    <name>A0A6G0XDI6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_005842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000077">
        <property type="protein sequence ID" value="KAF0738283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XDI6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012120"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00136">
        <property type="entry name" value="PDZ_canonical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="124"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0738283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="214" mass="23632" checksum="15C60B0435424408" modified="2020-08-12" version="1">MGQKWSKEPEDYYLGNGGSPYGLNHITGILSHDRRTDVIFPEGESTVVIGSRSGLSLLDVKTKKNKVPDMLRRLGLVVRTHGSRLTKSASVVVTDMLRVDASGKLVPRNKTYGLDVRNWRGTKGPAEASGAIRIGDAIYSINGARVPNKSRSQIIKMLGELSSRQLIITFRHGETMAQVPWEMEHCIDPPEGDYVEPDNEWGFLTPMKLGSVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XEK5</accession>
    <name>A0A6G0XEK5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_005550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000071">
        <property type="protein sequence ID" value="KAF0738622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XEK5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013744"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0738622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="286" mass="32802" checksum="C83A3876A9C230F7" modified="2020-08-12" version="1">MEFKHFVHVFNGKSYTDWECRLLAYLDYKEVLEVVEGKIPESDDTYTAKNKLARAIILAALDNTHVRMVSNIATASGMLKLLQQRYGNKSFMGESYLYQSLLELRIRPNESAVAYIDRFKTCIEDVQSAGMNIEPKFSVHVFFNSLDARFETFVNFYSNTFQNGVAIDDGTLQELFTALIQQEIRNKSTTHDAALNTSRHGPKRNGRPHHKQQQSKPSSVTCSYCNKRNHSVDECRIKAADERRQSESSNTTSRRARFQDTIHLQTHVRTNNPLSVRMVDQAPLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XEM9</accession>
    <name>A0A6G0XEM9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta-lactamase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_005643</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000073">
        <property type="protein sequence ID" value="KAF0738531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XEM9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012149"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050491">
        <property type="entry name" value="AmpC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825:SF9">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825">
        <property type="entry name" value="D-ALANYL-D-ALANINE-CARBOXYPEPTIDASE/ENDOPEPTIDASE AMPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026212076" description="Beta-lactamase-related domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-related" evidence="2">
        <location>
            <begin position="32"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0738531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="523" mass="56851" checksum="4BD1F8D3584299EB" modified="2020-08-12" version="1">MKLIQAMLAMIYAVGCAVAQDSVDAKVKRAADFIQNRLVEAKIPGMAISVVYQNKTVLAQGFGTKEFGNPDAPVLDTTLFQIGSNTKTFIAVALAKLKDDNKLNWTDPVVKHLPWFQLYDKYAQKLTTIQDFLTHNSVFGDHEGDLPTNLGGFGNERQSVEALKYLETSPRVGAGFAYSNLGYNVLGQVIEAISGQTWHDYLRDAIWAPLGMTSTYGYADAAPSGERSWGHDICNGTVAGPYDVTSTMGAKDMATFSKFILAKGSPLFKSSAVISELVTGHHSYSMTKLSATLNGYEFEPDGNAVAAGYGFDIVGQILFGHHYFTKNGAMVTHRSQVGYVPDAGLAVTVMWNANHDKGFASEQFRLSWMTSYLAGIFLDVNQTKLSLQFQSAMDSSNKLIPFKTCDAHFFGGKPWPSDNNTVGEPSPWVGKYTPPVSGQYYGTISITQDDRGKLNLQYGKYNSTMVLETKDNYILTTAVAGPITRRVLFSKTASGAPVLQIPDYLVAVRGSAVHACGDGNALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XFN7</accession>
    <name>A0A6G0XFN7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GH10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_005267</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000067">
        <property type="protein sequence ID" value="KAF0739087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XFN7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004743"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH10" evidence="5">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0739087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="115" mass="12789" checksum="6BA8C657AE8D2B7E" modified="2020-08-12" version="1">MKMRGHCLVWHNQMPRFYCSNFVNDGCTAATLTSSELLQLIETRMQKTFAALNDPQIIAWSVLYEAAAGDGCGFKHDILYNMIGSDYVPAKLNLRGVVSAPHMCVCVSAQVKFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XFQ6</accession>
    <name>A0A6G0XFQ6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_005286</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000067">
        <property type="protein sequence ID" value="KAF0739107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XFQ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010974"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22970">
        <property type="entry name" value="DD_NDKH5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0739107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="162" mass="17552" checksum="5683D9B173E14592" modified="2020-08-12" version="1">MAQLPGPVFQVNVHFEGNDHSISLYDAEPGGLVAIVVNTGTNAKYIRAFSTANLRATQVTKTKPDYYRLAESLYLAPAGGTHELQIHSSLRGMSQPEAIATAEAAHHYLTNASSGPEKFTQVLSRGLVMLCKDKPMGLQAVTRLGKWLVENNPNRPKVVLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XGS6</accession>
    <name>A0A6G0XGS6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_004898</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000064">
        <property type="protein sequence ID" value="KAF0739329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XGS6"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0739329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="98" mass="11402" checksum="54C2D770386C2009" modified="2020-08-12" version="1">MPVEEIISELVAFLEEMSVDEIQSLEKTHLALYERAKLRCNQEKAAMNEWELANPEFKPWNPTYLQLNQSLYDAERVWKIARLKAAAVDETKGKLHAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XHC5</accession>
    <name>A0A6G0XHC5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_004830</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000063">
        <property type="protein sequence ID" value="KAF0739658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XHC5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001211"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815:SF3">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026004363" description="Thioredoxin domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1156"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="118"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="259"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="742"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="998"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0739658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1193" mass="133183" checksum="B48331040154B330" modified="2020-08-12" version="1">MSRFYLAICALLGVAVAAVIELTTDSFEATTHALDGDNGDWFIQFYTATNHAPVWPDLSDALDGKVHVGQVDAEANEDLNKRFGLTGLASPTFIMISQGAVYVRFQGDRSIDGLTHYALGGFKDSSFISVPPVDGELPRDFHMASPESRAVILTDENFDQLTEAATGNAGVWLVVFHAPWCKHCKPLKPVLEQLAPRLEAEDIHVAMVDADQYVSLKTRFRVRSLPSVIVFAEGKLHRYFGDRSPQSLAAFAQGGYLKGGSDEIVPPRTSRFDQSSSRVVDVTPESLDKMTHIQTGDSGDWLIMFHAPECGPCRELAPVLDEVSASLGNEISLARVLVDKKRDVSKRFGIMGYPSIIMFSEGKMYRRFIGKRTVDNLIDFAAENFEELPSIPVPAPGEVTRFEFHDWMPRKEGDKSTEEDIIDEDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDEDEDDDDEDDDEDDKEENDDDKDKNEDEDDDEDEDDKEENDDDEDKNEDEDEDDDHGDENDANEEVKKNSVDQSHASENESTTTIPDTDVKQSEDASMDSDGAESESVETSDDDDDDNDDDDDDDDNDDDDDDDDDDEDDDDNDDEDDDDDDDDESEYGALDSVGNVIVLSEREFDLFIQSKADTGAWLIAFMDDDAENWEALFDVYDEAAHNLRDAPKLTIAQVDVETYPRFQRQLALSVENLPTLILFVNGTMTRYEGTWTAPTLEVFALGGYKQVEAFRLPEIHDIATWENVPTGDVVSLTADSFDQIKRTSKPWFVKFYADWCSHCRRLEPIWNGVAIELKTQVHVGQIDVVTNKALSKLFRLQGLPTILYFEHGQMFKYKGKRTLPALAAFARAPKDIADAMPIPSAIVEDTISDDLRKRNSSSAMPLSDLTFDDMLKVDTEMPWLLVLYTPPLPDLVEDLASLLKGNITVGRINVDSEKCIEVVARFRSFDFSLPAILAVSHGQMHRYVGEFSADPITAFATGGFKENPVLALPENDDSSDVVDLNATTFDELTSNNGTWLIAFHTPKCTQCKRLIPLLTKVATDLKADEDIHVGKVDSPSTALKKRFGLREYPTLIVLSNGSTSRYVGQHTQEGLAAYARGGYLLEPENAKSTLPERFDIVSGRIATIQRWAQEDSTTLGILLMTATILGLVFGLFIGGCCSGKHYDPRPKYLKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XIX4</accession>
    <name>A0A6G0XIX4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial</fullName>
            <ecNumber evidence="11">1.14.15.45</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">2-methoxy-6-polyprenolphenol 4-hydroxylase</fullName>
            <ecNumber evidence="11">1.14.15.46</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_004242</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">FAD-dependent monooxygenase required for two non-consecutive steps during ubiquinone biosynthesis. Required for the C5-ring hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 4-hydroxy-3-(all-trans-polyprenyl)benzoic acid to 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid. Also acts downstream of coq4, for the C1-hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 2-methoxy-6-(all-trans-polyprenyl)phenol to 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol. The electrons required for the hydroxylation reaction are funneled indirectly to coq6 from NADPH via a ferredoxin/ferredoxin reductase system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 2-methoxy-6-(all-trans-polyprenyl)phenol + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:81183"/>
            <dbReference type="Rhea" id="RHEA-COMP:9551"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10858"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:62731"/>
            <dbReference type="ChEBI" id="CHEBI:84166"/>
            <dbReference type="EC" id="1.14.15.46"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = a 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:81195"/>
            <dbReference type="Rhea" id="RHEA-COMP:9514"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10930"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:64694"/>
            <dbReference type="ChEBI" id="CHEBI:78396"/>
            <dbReference type="EC" id="1.14.15.45"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of a multi-subunit COQ enzyme complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the UbiH/COQ6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.45" evidence="11"/>
    <dbReference type="EC" id="1.14.15.46" evidence="11"/>
    <dbReference type="EMBL" id="VJMJ01000053">
        <property type="protein sequence ID" value="KAF0740238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XIX4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016768"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120538">
        <property type="term" value="F:2-methoxy-6-polyprenolphenol 4-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106364">
        <property type="term" value="F:4-hydroxy-3-all-trans-polyprenylbenzoate oxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000021">
        <property type="entry name" value="Ubiquinone biosynthesis monooxygenase COQ6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03193">
        <property type="entry name" value="COQ6_monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018168">
        <property type="entry name" value="Ubi_Hdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010971">
        <property type="entry name" value="UbiH/COQ6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051205">
        <property type="entry name" value="UbiH/COQ6_monooxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000689">
        <property type="entry name" value="UbQ_mOase_COQ6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01988">
        <property type="entry name" value="Ubi-OHases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876:SF7">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01304">
        <property type="entry name" value="UBIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0274">FAD</keyword>
    <keyword evidence="3 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="domain" description="FAD-binding" evidence="12">
        <location>
            <begin position="43"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="12">
        <location>
            <begin position="351"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0740238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="484" mass="52334" checksum="D272CBF2285C76EA" modified="2020-08-12" version="1">MLVSRRVPAKVRAAICHVQSRSMAYFTEEAKAERDQRAKELQDVVIVGGGIVGSALACNLKSNPLFHGKKVTVIEPSPPKPAKGPLGIPDMRVYTITPASKRLLESIGAWSKIAPEHIAPFGHMQVWDAMGDGFIRFDAAKAQLKDGENLGYVLEHSVLQRALLERMEELAAQDDTNPLRILSPAEVRNFEGPNDVHRVGDIYLEDGTHIRSRLVVAADGGKSMIRSLSGLGTWGWSYDQQAVVATVKTDNVNTTAWQRFLPTGPVALLPIRDGYSSIVWSTNENHATELKAMSPEEFIEALNEALNKPSETPSPPQIPVLGNIFQGIHLAAQTILAAGALADPFQAPPKATEAVGRRVSFPLKLQHATRYTKEGVALIGDSAHSIHPLAGQGLNLGLADVTSLGNILAQGVESGLHLGDELFLKHYENDRKKANITMAMAMDGFKNLFGPTPGPVQVARNVGMSTLNAVEPVKTQIIKYAMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XN04</accession>
    <name>A0A6G0XN04_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nitric oxide dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_003045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000034">
        <property type="protein sequence ID" value="KAF0741854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XN04"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000945"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008941">
        <property type="term" value="F:nitric oxide dioxygenase NAD(P)H activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071500">
        <property type="term" value="P:cellular response to nitrosative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046210">
        <property type="term" value="P:nitric oxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396:SF6">
        <property type="entry name" value="ABL201WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396">
        <property type="entry name" value="FLAVOHEMOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0216">Detoxification</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0741854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="459" mass="51854" checksum="79B10D4FD8F058AF" modified="2020-08-12" version="1">MWERRVDVVMILDRISLSHCGCFWLAVPTLEYPLERRHYRKIPMGGNLSTKNSKAIFSTPDGAIGITYAFAQKYAKYMPFEMKMPVLTPRKVALIKENWAAICRGTNAFNPERHGSTDKFFHRTLYGLLFAVMPSLRCIFRSSLTMQGKSFASVVKVMTSVMTTNNIAERMQALARGHLKFGVRREDYTTMGVTFIRALEIISGDTWTKEIRDAYMTAYCLLYYLLLPVIAHNEPEPAKECIPATVTSIEIVSNNARRLTISYDFPLRFQPGDGILLGIGQHKRCFPIASFPNKPSSTLELVVDLATSDWICRYSVASQLRLFWVESSVNFEVDTPEAVPRRVLLVSHGLDAVPFVTMMKGLSAIRESYDGNVVALQVADSFDEIQGLQPPELTAWSQCSIHQAHTVTKDKLLEVTPKLAQTDLYVAGPPDFIAQVEREYLAAGGRKRVHVYSLDRYNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XN34</accession>
    <name>A0A6G0XN34_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_003034</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000034">
        <property type="protein sequence ID" value="KAF0741842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XN34"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000844"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF458">
        <property type="entry name" value="SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="456"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="10">
        <location>
            <begin position="39"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0741842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="491" mass="53834" checksum="D2A54A4ACFD181F9" modified="2020-08-12" version="1">MTATKAASISSLSKKDDDDDHDEINGGGDDSPAATPCGVFCNLTNSIVGAGVISIPHAMAQGGFLPICGLLVLCAFITLYAMNTIVRLGSYHHVDSFEDLAQVAFGIKGYLAVCFFQLTFSFGANCSYLVVIADTIPVVIGRLWNMHFARGEPVPSSHTPWYIVLLTDRACCVELVVVCILLPICIHRSFGSLEKFAGLSILSVSFCSLVILYKWLRSFTGSSSSSRSYDHDFVYDFIAIHPQGIFPALGSIAFAYVCQHQTYLVYNSMASTKCPRAFGRISRLGVAFAATLIFTLSVPGYCLFRSATRSDIFLNFTDLSDKLIQTCRLMTGLNMVLTYPQEFMVARHTLQSLLTHWRRTKKQQREVDVLFREQSKPFHVSHSDVRPADSTPLHVGLTLLLLGSTLLISMVDHHLGDITSLTGSFSAVALTFVLPAACHLKLGVPSKLYSPWQDAVVPWCTIVFGTVVFFVSTSTSVYAIHMRVMNATAIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XN39</accession>
    <name>A0A6G0XN39_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_002999</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000034">
        <property type="protein sequence ID" value="KAF0741806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XN39"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026109927" evidence="2">
        <location>
            <begin position="17"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0741806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="132" mass="14218" checksum="54240C7C9DF75AEB" modified="2020-08-12" version="1">MMQLTPLVLLLWTGVGMDPGRFAIPAELKFAARTSHVDATPVLLNVLLAFWTVFHAVVIAPTSKGFVVVKRFRFSDFCTLAQEMIALPADHALLHFALRAVSLAFRPSPLIAEGSTSGAGKVEGLSEENGIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XN45</accession>
    <name>A0A6G0XN45_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_003386</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000036">
        <property type="protein sequence ID" value="KAF0741721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XN45"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020859"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="65"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0741721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="171" mass="18807" checksum="49E1D56FB45BFE00" modified="2020-08-12" version="1">MVEVQAESKQTGNEFSHLMPAHYDLMLEYWGNRVGYRRDSLMTTEVAIEDGENGNDGIMQEFDEVSSGSDLDASGDMKGKKDADGHHDLKRRGFTETRESKRIAKAHTQADAIESGLFAIKDGLVSLGQSVGSKTDNEANNATLNQVLEAIQEQSAAMQAQAKIFERLLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XNR7</accession>
    <name>A0A6G0XNR7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_002774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000030">
        <property type="protein sequence ID" value="KAF0742100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XNR7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000187"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="385"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0742100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="417" mass="44057" checksum="419D9FFE9879BDB1" modified="2020-08-12" version="1">MSETLTTIAAPSAEPDATTIKALSINDITSTFGKESVLSSETAAKDMEISVVSLVESIHVKVGDKIQLAAKAPDGELGRVRLVVDPSTKQRLIVAPPIQDGVTSEVATFIIAPVGTTTANGTELTYNQPFHLHVASPEAGKPPLSVNNNPTGMPDAIGLQTLGEKGEMTFVFTKPKDNSKIQFNDANLVLTCTDSNRTRKNFNNVVTLLKKSKATVGHGGYFTSCKKGPAISFTIARPNQLPAARLTYREISDAQTESDARSDAKSVLVSEGPKRLDSFTTAVQTPLPPTPAESFLAEDLNLPYVPPAVVLSPTTLHTDQPLKDVPLSNATAPPQPHKHDSVEENGSEVVHVNNTSPAIQSSDRFANLPLKSPKPTADLKAALWAAQQAAPAQDTAADDSDDVPAAGCTPCAQCSIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XP95</accession>
    <name>A0A6G0XP95_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_002736</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000029">
        <property type="protein sequence ID" value="KAF0742334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XP95"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016021"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000509">
        <property type="entry name" value="U3 small nucleolar RNA-interacting protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039241">
        <property type="entry name" value="Rrp9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19865">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19865:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="138"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="198"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="240"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="282"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="371"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0742334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="466" mass="51133" checksum="575F90E386B35599" modified="2020-08-12" version="1">MKRKQQNKSNYKAKTKGKPKGGAAKKAKLGDDAFDWGDGNAHVASDSELSGEDNGKDDKDEEEDPFANETADETRVRLAKSYLGKLQDKFQDNDDDDDQDRLAKQLEKDVAESDGKLFKLVADKLASFEFDEESSKFLKGHNVTVTCVCTSEDGRLIYSAAKDGSILKWSITSDGVTKTKFIAPVDEDNDNKKPTKAVPDHKKTVLALALSSDNKYLASGGVDKILRVWNGESNECIESFKGHRDAISSLAFRTKAHMLFSGSFDRTVKHWNLTEMGYIETLFGHQNEITAVDCLQKDRVVSVGRDASVRLWKIPEETQLVFHGTGSIDCLAMINDEYYVTGDDSGSLVLWFNAKKKPTFTQRAAHGGAWITSVAVLPRTDLIASGSSDGFVRLWKANLKVRSLEAVGAVPVGEGFVNSLAFPKDGGFLVAGVGKEHRLGRWDVKKQGKNGVVLIALPSLDEDDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XTY3</accession>
    <name>A0A6G0XTY3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_001342</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000011">
        <property type="protein sequence ID" value="KAF0744079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XTY3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008319"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052980">
        <property type="entry name" value="Crinkler_effector"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33129:SF1">
        <property type="entry name" value="ATP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33129">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0744079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="386" mass="44729" checksum="124CB207447A70AA" modified="2020-08-12" version="1">MVTFTSPNFGWLDSMRKNVNAHRTLYMPVWELGELWDAVNLLSLNISSQELSNRYQQLGGVPRYCLQTESDDYQQGLVEIEEAIEKIKTFEDVQACFEKSMPTNLVAHRLLYYFPDTRSRRTATLRFGSDMIGQEIFKRLRVKLDREREKLILWLDGAGKASTFQGWLFETVVHEKLITGGDFTYVQLDQQRQKQVLSVNPTIGQYERFETNFSLEMVFRNVYQMPKSQSSKSIDSYILSTNRLFLFQITISNNHPVNSEGLVDFFAKLGLVNKIKQNPNFVQLIFVVPDGMRDTYSRQNLNSQDVPSMRDLMAADVVTIPRIGPVLRQKLNKKNIFTCSDLNHHAQDPEVKYEFELLTKYIARLNLVSDLSYLDMIPQFVLGMPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XUJ7</accession>
    <name>A0A6G0XUJ7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_001265</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000010">
        <property type="protein sequence ID" value="KAF0744123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XUJ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003360"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003871"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF3">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026343011" evidence="5">
        <location>
            <begin position="19"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1217"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="610"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="610"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="633"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0744123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1260" mass="137010" checksum="BF7F5926BF87E598" modified="2020-08-12" version="1">MRLGYTVLAAAIVGQTDAWWWSHKKTPAPTTTVATPVPTTSPVPQAIAADSEQASVHTVDVESIAWSSCSFATTSADTRLGECANVHVPLCYAGVCESDQFISVYVKRLNANEVSDTRQALWILPGQLGASSTSVESLLVKAFDLFQGSRSVYTLDRRGTGSSSFLSCESDISNTDNLVEYYTQCFNGINSKFGNGVAAAFSTTSAAHDVASLVQSSLFESTQVYLYGSNDGSYLAERVMHFAPSRVKGYILDNPQLEEFAGSSAPYYSNKDRLAGEVVAQVLALCDSDAFCASKIGPSAKETIQRVYTSLDSGESPCAALLSSFGDSTGVLYPSQVVSGKLSTWFSSSMDRLFIPAYIYRLRRCSDDDQAWIQRVHSTNSPQTSGDSELVHALVEFSELWETPPPSAAQLAQWSVDAVIAAANEVTTVKSSIEYCIFTGIRTSDCSDLPPLDHASSFVYPRDVYWNHPAAIPPQSSVLLLTGAPEGTALLQNVRRQRDAMAGQSKLLVEFPITATYSILDNSPIVHGVESLDVDCGAMILKSFLDSHGDFGQIQTTCKDLFNRPIAFDQWSTAQSISYFGSDDPYDGAVDNLAGDRSSDAPLPDLQTAEMSSEIEATTPTPDSPPVEPSANPDESNTNSPELVTTEAPSLATLPPVNVPDVAINWYPCSFTTTSSGDTPTADSELHAECADVAVPICHPGICQSTDKYTTVFIKRLKAKTWTPGTPILWFLQGGPGLASVGLEANMAQVYQHAQSDIDVYTMDHRGTGRSPLVDCPDDKNLTALASCLQTIKDAYGDDAPAAYSVTSAAADLRLILSSSLFANSEVFVYGVSYGTYLVERLMHLAPPVVKGYLLDSVQSEGFHGSSYPYLSNRARAVRGVVKQFFAACDADNFCNDKIGPSSEDLLRQVFQDLDAGLTDCAKVLQPISQSNGLARNSEIVGQTLYSWLQDRELRLYVPGALFRLSRCNPDDVEWTRTWKLANDPIAIEFERGPYLDGSGISFVVYYTTVFSELWQIPSPTVDELAQWAKEAYLNQGYELQAKALVERFCLFTNNADAVACQGFPSYNVKFTNPRDVYWNSTATIPEGASAILFSGAFDVHTPEQFAQDEFDNLVGDNKLLLKFPWSTHTILGNTIVDVNDDDIEGLVDCGTSIVVSYVQHRGLLSSTLTDCVAKVEKLDFAAYDVDVAADLLGSEDPYFTSDDQAAFVALIEPERLRWVEAMVALALICVVVVVRRRYTLRNTYIPIPHVVDSYGTTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XUL6</accession>
    <name>A0A6G0XUL6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_001285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000010">
        <property type="protein sequence ID" value="KAF0744143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XUL6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016512"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0744143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="106" mass="12003" checksum="7BDC76B5F840ABA3" modified="2020-08-12" version="1">MTLHLDANYDKTLLACDGYKGDLMKTFGRSQLPMDEELGHPTSGFLCVRTYTEPSASDAIDASYGWIVGGVVGFCIVVYILDGFFYKIYKRKQRQRSHLQCNLVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XV00</accession>
    <name>A0A6G0XV00_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_000977</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XV00"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004954"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000610">
        <property type="entry name" value="Multidrug resistance-associated ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000997">
        <property type="entry name" value="Multidrug resistance-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="703"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="758"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="834"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="951"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="982"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="97"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="409"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="717"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1038"/>
            <end position="1267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0744501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1273" mass="137665" checksum="C2A58083B0C74A69" modified="2020-08-12" version="1">MTKATQPSYDSLAAASVSKPRSVAPPTASAGFASKLVFGWASPLLYTGSRRRLDPEDLWPLAPENQCAPLGTAFEETFARTKSLLSAFISTHGSTALMIVGLQIAMIVMSYIPPLALQQILQAIEGSDFQMDVVAQAIGFLFLAKIASAFVTVHADYLTTLVIARVAGALQHMLFQKTLLLDGARRREKGGAGDIANLFSSDMQWITTLSSRISAVWSSPIMIVVTLNMLYNVIGWAAFVGSGALVFAFVVNHGITILQRSILTKYMGEKDARMKAVAEIFSAMKIVKLQAWEERFEAKIDALRQTELKTLGHYVLAEAMQTALMFTTPVIVTLVSFFTYTIVMEETLSVSKIFTAMSLFNMLKYPMMGLPSALVSLMQAVVALQRMQDFLHLDEKRPTGDLAASTGSIVVEDATFGWDASSVLFDSVNLTIRRKELVVVHGPVSHGKSALCQALLGELTTHRGSVSLGGRVAYVPQKPWIQHMTIRDNILFGQPYDRRKYNAVVAACGLTTDLAGFPAGDRTEVGLRGMNLSGGQQARISLARACYSDADIFILDAPLAAVDAAVQREIFAQCICGLLRHKTVVLVTHNADIIHSPHVHRTICVEDGHLMDHVKARDEQPDEEPPLAAVAPVVVRPAVINETHAVVVEVGPVVKSPVALSADAVLLFHDLDESHDDDDKRILSGKLIVDEARSEGRVSAAVFWSYVVASGGWPMLLGILILLVANQLMQVAGDLWLSTWSNTAAHVTPATFLAESGAYLTIYSILVLSGCILSVARAVVGWLAGLRASRVCFESMTAALFRAPMGFFDANPVGRILNRYGNDMTSIDTRIPSAAAAFLALSAAAVSTIGTTIIAMHSMAFLILPLLYLYYRMAAFYLRSARAIERVNTVTKSPLLNLTAEAIDGADVVRAFGPAHVARLEERHHANVDRTNEAFVTAQVASLWFTLRTQLFSACTLLAIALSLVAMRLVLSPGVIGLVLNYSFGIFPVLEMVVALWSILETQMVAPERVAEYAAVVSEPPRVLPGSVTKAWPTSGKIEFDDVSFKYKEAGPLVLQRVNVSIADGEKIGLVGRSGAGKSSLTMALFRMYELPSGSIRIDGVDISTVGVQTLRSRLAIIPQSPVLFQGPLRNYLDPAGDHGDDDLWSVLRQVNMADRVALDADVEEHGANSSAGERQILCLARALLCHAKILVLDEATASTDAATDARLQQVIRTSFASSTVLIIAHRLESVMNCDRIMVFERGQVVQCDSPKTLLEKGSGAFYELSAASSGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XVL5</accession>
    <name>A0A6G0XVL5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MADS-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_001001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XVL5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009259"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00265">
        <property type="entry name" value="MADS_MEF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033896">
        <property type="entry name" value="MEF2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11945">
        <property type="entry name" value="MADS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11945:SF534">
        <property type="entry name" value="MYOCYTE-SPECIFIC ENHANCER FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00350">
        <property type="entry name" value="MADS_BOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="7">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="89"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="227"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="267"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0744527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="332" mass="37431" checksum="E30DACC0B2609187" modified="2020-08-12" version="1">MGRKKIKIQRIDDDRNRQVTFAKRKTGIFKKAMELSKLCDCEIALIVFDSNDKLYQYSSTSVDQILLKYTEYGEPYETKDNADYDTLFGENKKKGGSDSSPYGGISSHESSPAYSGMTMSQNDRMLGAGVSGVSLGLTNDPDQYMLNSHRNMNKKRTPKGFQQLLQKKDMQYVPPQLPLYQQNLGMLNSVHGNHMLSSLPSPPNLHGILPSPTTANMLLRHEFSPQNADSMHMGGMGEENDKSGGVLGLNLGPNDFNKGNYHPQRGNDPNSSPYDTPSKSMNQQHHHYMNHPDSFAHKHHYEDDNQQDDDDDDCGDNRDRPDNPKRMRVTTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XVN8</accession>
    <name>A0A6G0XVN8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_001206</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XVN8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002218"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0744751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="267" mass="30381" checksum="F59656238D74810D" modified="2020-08-12" version="1">MAATTTSFPCRDSNQRLRALSVETMPPQFNLRPRSLSHNQGQTSTYSRYRAFRKSTTNVRVESPSFVGDPAAQVKETKDGAEMTAREESPEQIKQVQWSRTLSPLKAHPTYIDTESYEDLIFKIANLTPDSSRSVLLQVSDFLSRAATYLGYTYDVFPSNLDCSKLTSADIVAWQQLARYPWECEAEFEHLRTDRSGKLMDVTIVPGATRSLLQRLFNKPKGPRRMQLDSVTVRRLRCVQEVANTCLSFGHFQFTLVDIAQLCFAEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XVP3</accession>
    <name>A0A6G0XVP3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcriptional coactivator p15 (PC4) C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_001002</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transcriptional coactivator PC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XVP3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009258"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.31.10">
        <property type="entry name" value="Transcriptional Coactivator Pc4, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003173">
        <property type="entry name" value="PC4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009044">
        <property type="entry name" value="ssDNA-bd_transcriptional_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045125">
        <property type="entry name" value="Sub1/Tcp4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13215">
        <property type="entry name" value="RNA POLYMERASE II TRANSCRIPTIONAL COACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02229">
        <property type="entry name" value="PC4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54447">
        <property type="entry name" value="ssDNA-binding transcriptional regulator domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcriptional coactivator p15 (PC4) C-terminal" evidence="8">
        <location>
            <begin position="63"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Transcriptional coactivator p15 (PC4) C-terminal" evidence="8">
        <location>
            <begin position="150"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0744528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="216" mass="24416" checksum="2D4E982A04809B7C" modified="2020-08-12" version="1">MSSVAALEKPKATAIVKEEIEETPVPATKRERSASLDEEPVGKKLKSSSEVQGEKHEDGSVLFDLTSKKQVSVRTWKNAVMVDIREYYYSNGEMKPTKKGISLTKDQWKTVVSLADDIVKAVDWVQNPSKRALDYQAETLDDVETNSVAFSISSTRRATVRKFKSMILIDFREYYDANGTMKPGQKGVSLKKEQWEMLHERFDAIDAAMEELGQQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XWQ6</accession>
    <name>A0A6G0XWQ6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_000593</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000003">
        <property type="protein sequence ID" value="KAF0745012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XWQ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004127"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00106">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF33">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3 4" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="7">
        <location>
            <begin position="1"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="335"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="479"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="542"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="305"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="444"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="338"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="374"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="542"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="17"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0745012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="615" mass="67616" checksum="F280FCAAF482673F" modified="2020-08-12" version="1">MIGNVLDGFHATIFAYGQTGSGKTFTMEGYEYEKQQARGDRVQAKPKVDVSSDRLGIVPRVILELFQAIAAASVDKKREFTVRCSFVQIYNEQILDLLNPATSLTRVKPLRLRWAANEEFYVENLVLHACSSADEMLGRFHDGVKQKIMATHNLNAASSRSHCIYTLYVESVDPANPDDVTKAKLSLVDLAGSERVVKTGATGVTLQESIGINKSLFMLRQVIQTLSDDGSTGSAATSHVPYRDSKLTALLKHSLGGNSITLMVACLSPCDAFTEENLSTLVYAARAQSISNKPVKNEDPKTLLIQKLRDEVANLKEQLAQAQLVILRLTGDESVPETTATTTTTTPTTTAIEPLPPERYDEDDLAPRKAVPTPQKSQVPRGIPNNQVETPSTPPEGRAPVVVVDSTDKKKLKMNVIDNVELIKNMVKNERQLWSQIESAGAETNKLKMENRTLNLENQSLREKIEVLEYLVVKDDDGGEFVPAPPQERIDQVLNSRVKPSRSQGSLRPHSTADKPSATLEPEKKKRETGMLSISELRHLLHKKGNDEGAKKQRSSAKVSPTALQPPPHPVAALLTTLESNNNNSALEQDSLQSLSELNRLLKVKAAMKHGSISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XX34</accession>
    <name>A0A6G0XX34_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphatidylinositol-3,4-bisphosphate 4-phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.66</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_000576</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Signal transduction; phosphatidylinositol signaling pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the inositol 3,4-bisphosphate 4-phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.66" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000003">
        <property type="protein sequence ID" value="KAF0744993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XX34"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014741"/>
    <dbReference type="UniPathway" id="UPA00944"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016316">
        <property type="term" value="F:phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039034">
        <property type="entry name" value="INPP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12187">
        <property type="entry name" value="AGAP000124-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12187:SF11">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3,4-BISPHOSPHATE 4-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="7">
        <location>
            <begin position="298"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="314"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="367"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="332"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="372"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0744993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1011" mass="112026" checksum="A1C0839319A3BE9D" modified="2020-08-12" version="1">MATDNLEPVIQAKLATESAPPAPQIAPATPLSPTNSANVEKLTRPPLDPATLSFRSLRKELITVFVETTNLNLPNLPQTFFQSIFKGKKPDSALAECRIEVDLKLAGENAAIVYHQTTEALRSRNLSFSVGLTIPVPLAKANCDEYHLYFRVVQTDEGFEKTVATAEMMCLMLLESFKQGAPVMHLPLHMTSNHEAIMSLTFARAFPIKHNIMPVQNTLMHMYAFSSTKEKKEETTLLASEELVEVGYASSIPPIFLAQCRLELEAAHRLWNVRYNNARKSALLFESQEEALANGCDVYSVEIIRARGLSLPADLSLQPEPSSPANGGRPRSASTGRQRSGSNPSKPQAAITCNPFVAIKFRESSKGTRPIEVSEGKTSIEKNTGEPHWSSDGKPSKPIVFYRPNQSGRTVKRTLEIDVMSECASHFDGEIPLGNVAIPIDAVMYEGMNATYSINLTNWLPIKTDTGEERGEILIHLQMRRATTVFSLDPEPSLAPGSLFHLADPKRHTKWVSNMEAKEYSPPQSIAEIQNIVVAHKNALDQVNGWLDYAEKNTAEWFRSSEWKVKNEVQSKATNLHVSYFRIYKGQDRARETVLEGRPRDVEVNVLPGEQLELTASLRKLIGNRGSRFSLEDLIDHDSPLEVKATYSTVTCGAPTAHALGLSQFGLVELEDKLLSVDAPLELNRCTYALRKSVCMSQALSALVATFMSQLELALQNGGWMLEQWMAVGFLIGWESLVSTQGKELHMLSDSWVAIKSLERVKIQLVAHSELMTFTAADTGYILQLPLPAAAFSQLPQPLQDCQLISITAVLFTQGINEMQTLANVVGAIGIALQVRINVKCCAVLREYHERLMAAPSLAGMTAQMKAMKLDTLSALIANSNETTMTKKNHRILLEASDDIRRLNGGRVTFCKSGKDRTAMSVTLDQARIVGSLWKEGAPLLIHDQGQNVDWTLLKPVANLMREFGVRIEVAKKNVGQLRYSFNSLQRKMLPKMYRPPRSAIIKGDHEVDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XX88</accession>
    <name>A0A6G0XX88_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pirin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_000376</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pirin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XX88"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019689"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02247">
        <property type="entry name" value="cupin_pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02909">
        <property type="entry name" value="cupin_pirin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008778">
        <property type="entry name" value="Pirin_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903:SF8">
        <property type="entry name" value="PIRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903">
        <property type="entry name" value="PIRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05726">
        <property type="entry name" value="Pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin N-terminal" evidence="4">
        <location>
            <begin position="25"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin C-terminal" evidence="5">
        <location>
            <begin position="175"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006232-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0745350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="32628" checksum="B32405B58520647D" modified="2020-08-12" version="1">MTQTTRRAAKSFVSIAQREGVGAIVRRSIGHPMLRRLDPFLMLDEFNVTLPGGFPDHPHRGFETVTYLLPDSPGSFVHEDFCGHRGELNPGDLQWMCPGRGIVHAEMPLSHDTPAIGLQLWVNLPAKLKMTAPKYQEIPASGLSRAKEGNVEAIVIAGEAMGKQSNVFTNHPITYVHFLFSAPATHFHPLPSSHNSFVYVISGSGKIGGESVESHSVVLLTKEDNQNGIELEAIGGPMQCVVLSGEPIGEPIEQYGPFVMTTRGELQQTIADYQRGRNGFENAAAWQSKISQLAHSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XXK1</accession>
    <name>A0A6G0XXK1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_000261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XXK1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019643"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0745228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="165" mass="18704" checksum="405651500177CCE9" modified="2020-08-12" version="1">MVAVSKSTLLVSDESGKCRYKTGKCMNDRSFKRNGQYHQLCLFHREKANRIQRKFDRQKRSIAKENKSNQKSTDNAKVLETTLSFGNHRDVEFFSDTDSCDGRLSVDSCDGLFKDDIWSSPISDHGISIKLEHIGDPEPVPVNSPVTHQGRLSVDEIDFLCSAMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XXY3</accession>
    <name>A0A6G0XXY3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_000416</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XXY3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001277"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF148">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="5" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="22"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="START" evidence="8">
        <location>
            <begin position="246"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="126"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="844"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="847"/>
            <end position="857"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0745397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="865" mass="95576" checksum="6AC8B50E3E907120" modified="2020-08-12" version="1">MGDRSHDEDHHSICNRPGYDPTYMKEGYLQKKGQLLKGWKKRWFVCDGRSLSYYNTKLDKKPNAVIPLESATVQDGGTSETWNSPRIYLTDGTSGTMYCLSGDEGDVVSQWLEILDRAVKRIHEKREANQNGVPRSKSHITPFDEEEGRQKPLLQPPERSPRKIPSSAEFASKRAHSAATAPASKGTQLSTTIRLENELSTASELLNSLLLNKPSAAHPIRFQFEGVHDGVRVSTAVDPTTGKRYARGSVVINVVPSVALRIVVDHQKRHEWDIHFPESSHVATYGGATDLVYLSGGSPASFFSDPVLLHPMPALPAAVAAVFGGVFSTDGLLHAAAGAVLGGVAASIDWRPLAAPRDLLLLRHVYEAMTPASDQTRLSCQHLLEAVGVTSVANAMVIAEMSVTNELKPVVSGVIRSHIGVSGWLVEPLDTEATLLTYVTDLTLQGWIPSHVNARVLLDRMKCLSAIAHFVNQAKILGPQLGYDDDVVYDPDEVEDGGIGGSTDVTAAATRDSDTFHPRDYFRMVVQIPTGGVKLTDKDIAKKQNGVLMEVIKNMGTKLLDGKSAVSLSLPVRIFEPRSMLDRLVDLYLYAPNYLSAANDTSDMVERFKLTMAFAVAGWHHSVGCMKPFSPILGETLQTEFVDGATVHCEHASHHPPISYAQIVGPKYKIHSYSILNGSLQTNCIVQIQQGPVKVQFLDGTVIEFTLPAIRMGGFLWGDRVVELVGTINFQDKKNGISCELKLNPDEKKGMFASNKVPTDRFRGTLISRMDEVCEVSGSWLEELRFGDKVYWNLHKDRCAPVVRLPDDKVLASDSRHRQDLKFLGQNDLEEAQEWKLTLEKLQRSDRAKRKEGRRPNHWTFQSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XXZ8</accession>
    <name>A0A6G0XXZ8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Hexose transporter 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Ae201684_000081</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-fructose(out) = D-fructose(in)</text>
            <dbReference type="Rhea" id="RHEA:60372"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:60373"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>D-galactose(in) = D-galactose(out)</text>
            <dbReference type="Rhea" id="RHEA:34915"/>
            <dbReference type="ChEBI" id="CHEBI:4139"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="7">
            <dbReference type="Rhea" id="RHEA:34917"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-glucosamine(out) = D-glucosamine(in)</text>
            <dbReference type="Rhea" id="RHEA:78423"/>
            <dbReference type="ChEBI" id="CHEBI:58723"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:78424"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-glucose(out) = D-glucose(in)</text>
            <dbReference type="Rhea" id="RHEA:60376"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:60377"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-mannose(out) = D-mannose(in)</text>
            <dbReference type="Rhea" id="RHEA:78391"/>
            <dbReference type="ChEBI" id="CHEBI:4208"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:78392"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-xylose(out) = D-xylose(in)</text>
            <dbReference type="Rhea" id="RHEA:78427"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:78428"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000001">
        <property type="protein sequence ID" value="KAF0745628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XXZ8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011469"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015149">
        <property type="term" value="F:hexose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF8">
        <property type="entry name" value="FACILITATED GLUCOSE TRANSPORTER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="430"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="497"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="17">
        <location>
            <begin position="85"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="542"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="549"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF0745628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="563" mass="61302" checksum="E8235D3597C3B310" modified="2020-08-12" version="1">MVALDDKNLPAPSLQDGERISTPRQIDDEDVYVDIQDVKASTTPSKNTRAPSYRSLHRTSSRQTLSRLESFIHPEHSKALLPTTVLYVSVIISLIGSFQTGWLLTQLNFLPFNKGCDAVEIAPETCIMFPGHSKHEWTMAMAGWVVGAAVGAVVSGYPADKYGRKRTMFFNAFIMIVGAVLQATAQSIYLLALGRLISGIATGTAINVSNVFISEISPLQLRGMFSSGIQIGVAIGSLCVTSTHYIIGTGHYGWRIMVGTPILFGLIQIVFMPVMTQSPVWLVGQGRVEEAGAAMRKLYRPTDYNSVLNALAQSHEEEQREMAVVKPWAALFSRKYALQLLIAIVMCSAQQLSGINAVMYYSATIFNQTGISDPRVANTILNVLRTIAIFTAARIMDKFRRKTLLVGGMSVMAIASGVLVYALVHSKSALAVATVSIFVAAWGLSIGPMCWMVAAELFPDFLKANAGSVGTMCTWFFDTLVTIFYPVLASTDRMGNYAFFIFTGCLVAIVLFIVVIVPETSQKTYVEIAHSFGIEEQEHLEPVDAKVNSRGSSGGTTPRGDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XYC0</accession>
    <name>A0A6G0XYC0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">tRNA-dihydrouridine synthase</fullName>
            <ecNumber evidence="12">1.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Ae201684_000489</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 5,6-dihydrouridine in tRNA + NAD(+) = a uridine in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54452"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13887"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 5,6-dihydrouridine in tRNA + NADP(+) = a uridine in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23624"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13887"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12 14">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the dus family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.-" evidence="12"/>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XYC0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002332"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.80">
        <property type="entry name" value="Putative flavin oxidoreducatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001269">
        <property type="entry name" value="DUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024036">
        <property type="entry name" value="tRNA-dHydroUridine_Synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082:SF25">
        <property type="entry name" value="DUS-LIKE FMN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082">
        <property type="entry name" value="TRNA-DIHYDROURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006621">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 12 14" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="15">
        <location>
            <begin position="17"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="19"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="235"/>
            <end position="236"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR006621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR006621-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR006621-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF0745475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="336" mass="37916" checksum="E084C6BB8864D2B0" modified="2020-08-12" version="1">MTMASFWQKLPRPFFCVAPMANVTDLSFRATITEFGKPHVMWTEFVSCEALCSSSAASRERMLTTLRYLPAERPIVAQLFGSKPHQFRESAMLLRDLGFDGIDINMGCPEKNVNKQGSGAALILDPPNAQAIIRACKESGLPVSVKTRIGFKTIDYVDWVHRILDTEPEALTIHGRTRDEMSLVPAHWDAIGDIVHLVKDKRQSPCLVIGNGDVDSIPNALEKVHEFGVDGVMIGRGLFGNPWLFQGHRDATHFSVEERLHGLVRHTQHFETLLDGKAPFHHVKKMYGSYLVGIPFAKHLKEALSATTRPHEVYPLVEAFIEQEKQRRQQLDQRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W3Q3</accession>
    <name>A0A6G0W3Q3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">D-aminoacyl-tRNA deacylase</fullName>
            <ecNumber evidence="2 5">3.1.1.96</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_018995</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a D-aminoacyl-tRNA + H2O = a tRNA + a D-alpha-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13953"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:10124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:79333"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>glycyl-tRNA(Ala) + H2O = tRNA(Ala) + glycine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53744"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:13640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the DTD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.96" evidence="2 5"/>
    <dbReference type="EMBL" id="VJMJ01000372">
        <property type="protein sequence ID" value="KAF0721662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W3Q3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009913"/>
    <dbReference type="OrthoDB" id="275783at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051500">
        <property type="term" value="F:D-tyrosyl-tRNA(Tyr) deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.80.10:FF:000001">
        <property type="entry name" value="D-aminoacyl-tRNA deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="entry name" value="D-tyrosyl-tRNA(Tyr) deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003732">
        <property type="entry name" value="Daa-tRNA_deacyls_DTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00256">
        <property type="entry name" value="D-aminoacyl-tRNA deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472:SF5">
        <property type="entry name" value="D-AMINOACYL-TRNA DEACYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472">
        <property type="entry name" value="D-TYROSYL-TRNA TYR DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02580">
        <property type="entry name" value="Tyr_Deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69500">
        <property type="entry name" value="DTD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0721662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="154" mass="17108" checksum="42097815B9526A14" modified="2020-08-12" version="1">MKLVIQRVTSGCVKVEEQVVGSIGKGLVCLVGIGKDDTEEDADWCCRRILNSRLWPNEAGRAWSTSALQNNYQVLMVSQFTLHGYLNGNKPDFHLAMSPEPAKALFDNLVQRVRDAHTAPEQVQEGVFGAYMEVSLVNDGPVTLNLDSKVRNYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W564</accession>
    <name>A0A6G0W564_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_018529</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000339">
        <property type="protein sequence ID" value="KAF0722313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W564"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002087"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22677">
        <property type="entry name" value="FHA_Kanadaptin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050923">
        <property type="entry name" value="Cell_Proc_Reg/RNA_Proc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23308">
        <property type="entry name" value="NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="41"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="138"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="287"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="436"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="347"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="138"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="163"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="329"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="498"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0722313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="585" mass="64913" checksum="CBE6F442E4BA6D07" modified="2020-08-12" version="1">MTTYEEPEWALNGSNSHGLSLEVIKSGSIVDTIQLSTKSFFVAGRMEPLCDLVLQHPSVSRTHATFQFDRKGRLFLYDMSSTHGTFVNKKRIPAGEYTQVHVGDVIVFGESSRIYTVLGPPELMPEEYSSANLAKLRQKLDERKQQQRDKEDEGISWGFGEDAVNESDEDDDENDDEDDKKANSSVSKRSNTNLPDYLRNRQDANQTPYVSKVTKDNVNLAKDEKLYTRLQSKIQKMENLKLESTRIRAKQNVGLTDGQQVALGRCEGRIQALEEEIETLEAQLLAKHTQRTTQRELATTSKKKSQHAYDDDSDDDFYDRTKATNNPSTAGTAAATRATTKPKVMTMESIQATLNGLRQDLASVEKEVEKLPDTATDSATETEDSLDAYMQESNRQLRAQERAKALAEQTRLEGLIREQQALLDIATPAWAKLKASNEAAHAPQDDNKNAAEPALSAKQKESLTTGAREVATSPRRNTSEMTPVSPLKVVPAQTRAPSVEENKAREPQKTALEPPKQKRVEADAASPPSKRRKPQGPARPAPAPAAKPSKLSYDQSVLEGGDVVWQPPKNQTGDGRTALNDKYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W5S0</accession>
    <name>A0A6G0W5S0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_018486</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000337">
        <property type="protein sequence ID" value="KAF0722359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W5S0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019842"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0722359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="130" mass="14945" checksum="4EC07668B3264C4D" modified="2020-08-12" version="1">MSHLHNDSHCKYIYKVCSNPRTLKKDGSLHRLCEFHRTKANTLQKVYATKRRRERRAERKMLLEAKKCAAAAAATALVKTEPIKCEGEPGEFVLDTLADLFFDDKWAFDLIEFEVDGHNMLDDDVFVTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W6L0</accession>
    <name>A0A6G0W6L0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_018095</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000320">
        <property type="protein sequence ID" value="KAF0722864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W6L0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010640"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08958">
        <property type="entry name" value="FR_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000085">
        <property type="entry name" value="Dihydroflavonol reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="8"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0722864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="327" mass="35975" checksum="2635BB18434DD465" modified="2020-08-12" version="1">MPSVPQVICVTGGSGFLGSYCVKLLLERGYRVQTTVRDPTNEKKVGHLKALPGANERLTIFKANLLEEGSFDEAIKDCSVVLHTASPVELKNQNRDQLVAPAVQGTLNVLRSAARTPGIRRVVLTSSMAAVYIHCDTKPVEHVFTEDDWSHEELIEMNKMWYCVSKTLAERAAWNFMENLSDAHFDLVAMCPTRIHGPMFKIELNESSEKIYDNLVGNVNDIPRVTRSVVDVRDVAFAHIAAFENPQASGRYTLVAASPTEEEIARAVKAARPNAPVASKLAHGTGFVAKHCSSAKAEKELGIRFIPLEDMVRETCDSLTRIGLVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W765</accession>
    <name>A0A6G0W765_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_018044</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000319">
        <property type="protein sequence ID" value="KAF0722969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W765"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010210"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0722969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="637" mass="74578" checksum="23A945BB3E112405" modified="2020-08-12" version="1">MKKKRTAGKPVVRRIRDELSRKAAKEGVWSVSNQHQVVQGRTQLFQAHLEMSLKKHFKPSLLRLDAAPVEKDIIYESIRVDASLQLSKQLYMLEFAFRRFAFRWRKIKLHSGIHLWATNIQLLKKHICHQRILARHATKIQRCFRAKRNRDVEASQRVSLAAQLEAIIQEQARLKQKHFQEVRAAIRIQCHCRGFLARVMWHSLLRHRLFNALSTLSIHQLFGSLEEVQVAGGHFYATTDEDIQVIHDAHHWLHTHVPPFMTAQRLNCIEQVEAIGNRRVSQGVVIRTKQRHTYWSMLENHLAEISLKEARNMRIAERKMERLRIRQARHHRHADELRGVRNLLSWQEERQRQEQSERELMGEEEVWTRQYDVNYARYESRLKSEAVKRSIALLRSSVKQQLGELEMAREEIRRMRHEEEIQRLALCVERATKCWIYHIGVWRTIVVAYLAHTKAMPIAAIDVIFCMSSSASSSSIVHRVTNATELRQGLWERFSQDYATPLCFRRQRHVHHQVRLVGSAVECMTIRVESSMVNVDLTRCNGELVSNFKLSSPLLAVLSMLERSRVAWLRPKNISKLMEWIVSCVKWISPQRGLVFIPPIELASHSYPSSSIPMLQAVVQKGVDDLQRFFTMSQVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W7G8</accession>
    <name>A0A6G0W7G8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_017920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000317">
        <property type="protein sequence ID" value="KAF0723049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W7G8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005065"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0723049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="260" mass="29569" checksum="3CF702F729E59A97" modified="2020-08-12" version="1">MASIDGFDQRGHNYNSVRFASMPQDSFDVCLAYTPDGVPLTITMASRSSKTIWTFQTNSLGDSRVTFNSKELSPCKVVNALVTWLQEGNKLPRLNVKMDLKPASYSVLRLLREIDDAETNEKAIYAFEMVPQAIYVGVKAAITPSPEEKTRSKSFRLALVSDCPKLKQFAKWKVDPSLGGRHFELSKDGTSITALQAGKYHVQFSAQWNPVSEWEAHFNLYVNSARKRRSNDGRFRSSWKTKSDCHWRKMTFYDSFVVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W7R9</accession>
    <name>A0A6G0W7R9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_017899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000314">
        <property type="protein sequence ID" value="KAF0723152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W7R9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017990"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0723152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="124" mass="13959" checksum="D6AEFC5B89990246" modified="2020-08-12" version="1">MQPASDVLRCLYSNKSCPNPRTTKKDGSLHRLCAYHQEKANNRQKQYLLKRKNMEERQAKQPAATTAAAAARPAVLREVITPAVLLEPIAFHDEEAKLSDHDVQMLAASMVPDEDEDDDFDSDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W7W3</accession>
    <name>A0A6G0W7W3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_017864</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the unc-93 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000313">
        <property type="protein sequence ID" value="KAF0723248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W7W3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021533"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051951">
        <property type="entry name" value="UNC-93_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19444:SF13">
        <property type="entry name" value="PROTEIN UNC-93 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19444">
        <property type="entry name" value="UNC-93 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0723248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="485" mass="52793" checksum="1F31B5A4BCBD350C" modified="2020-08-12" version="1">MRAAGEHPPPSVRSSHWPNNMLDANECIRTGLLLSFGFLLIFTAYNATEVLETSIIPSHCEGCVSGPATGMCQWEGVCQEKTQFSCDVVCAAPFNECKSRLGNVVLGTNYFTFMAASIAGPLIPYHFGEKWTMAGSSIFYGFFALANLVVASNPTDVPLQWGVMMPMSVISGTSAAFLWICQASYLTHLSVIYSKLNGMPKVASVGYFNGLFFSIYRVSSITGNAISSIVLGYLAWSTSTLFVIYATISFLGASLLFFVPTLPPLVAEEELELLKEHQPIIVPDMPQSTMQALFSLALDRRMLLLAPAMILNGIQQGFMTGEFTSNIIRESLGSPSIGTVFVLVGFTAVYSSYAFGKLADRYGPLWGQLVCFAVLLGAYILSYLAPVTKCDGQWGLNLLLAVLIGMGDASSLTLVNVVLGQEFPTDSVNAFSIFRVYHAGGSSFSFLFFPSLSFHGRLIFLIASVVVSAVTFLWYYLRYRAVAQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W8D5</accession>
    <name>A0A6G0W8D5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_017653</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000307">
        <property type="protein sequence ID" value="KAF0723423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002135"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005216">
        <property type="term" value="F:monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126:SF14">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="951"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1005"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1044"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1075"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1111"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1169"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="36"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="69"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="197"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="230"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="530"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="726"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="10">
        <location>
            <begin position="1020"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1261"/>
            <end position="1309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0723423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1327" mass="148668" checksum="A4006DB3536C7880" modified="2020-08-12" version="1">MDGALRAATEQELLGWLSSSPSALGVDLLEYRTPTTEESLLHLAISREFTTVVHKLVSKNVDVNAQDHQGKTPLMRAIEMRNMDMVRILIEAKSDLSIKCRDGYSALYIAAEDVSRLDIARFILPYVKDEGAHELFEAIVENDADVLENLLAAGVSSSLRRPDVLQTPAIHSAIHNTMLLSILLEHDRTLVDCKDRQGQTALGIASILGELDAVKMLLQYGANIELKDFRGRTPLHLATFYEQLEVVEYYVEQGASIEARDDDQRTPLHSMAEKGNLRGCTLLCRAKAKLNALDIHGWSPMHLAASLGHSEVCAFFVHEGGLLLEWSDSILCRPSLTANAWISVSPNKLCMIYSELWDLGVPQTKAKYGTLRIRDLEMNTLMHITASFASTVDAEYLLTALQHHVPLNVQNCMRATPAQSAKAEPTIQFLRAMGSRDFGTATLQNLSVDAFSTCSSMKLLMIIHEITEGYSNLGDPTTMCVSNETGDTVLHVFVDSIKQFSDDTQRSMLSSSQWLNASEATLFLDKMNWAGKTPLHVAAAIGAKGACRALLDHGAKAGLGVGVPDDRLKIATNLATEGWTALNFGLEIGYDELILDLMGEAGIFPTESTALAQLKQSMATKRPRLLPLLYQRMSDNSTDVLLLEAKSRAAEFVPKTDPTAWTVFRAVLEAERYGVDALKKYACKDLIIRSTGDTLLHIFAMDAARIPEMTYLLTQEKFFVDTPNLRRKTPLHYACQVHSFAMVSFLLSHGADLRASHRVLRPPPVTSLLDALSLHIDDLTASKSEQSTSSTILTKSAAHVRESSVDPMTEQWQTPLHLCLSQRMDELTGEQQQATTAIIELLLQHPHSIMEPSVAAFGPYPSESTQCGWNAYVFERLLADFPQSLPLYLNHFMAASTWYGSTTTSFNEVKEVCRNLDRMTHLTPVMLHPTVHNALKAKWRLYGHRLYRRELFFSVLLVLCFTMSNYTVVTPQDDKDLDTPSANTSSSLLASSYSWFAFATTQDDVVGVFKFLTWALALYHLVYVELWQELRLQTKAYWRSMWNYINLATYLLLLASLPLEYAYVRPAIVESCLSLASILLLFGLMQSLLVYPYFSVLLFTFSRMVRVAIRFCCLHVILLIGFTAAFYLVYHGKEGHETLTHSFATVFFITFGEIQFHDYYSNVASPYRYTFGMVVIVAYIICVNLVGLNMLIAMMTSEYEEIKTQAEVLSTQQLASTMHRYETWLGDKRLDALYESSDVWSFTQVSKKASVIPGAVDSTEISQLKTMVAQLSRDLVATREEGDTQKRENRELAQRVADLEQSMQQHMQTNHKMLQDIVQMMQKSQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W9P2</accession>
    <name>A0A6G0W9P2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_017334</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000294">
        <property type="protein sequence ID" value="KAF0723839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W9P2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006630"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007694"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0723839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="223" mass="25295" checksum="A71DE5CA26940B65" modified="2020-08-12" version="1">MDDAWDIATDLPFLIAKDDELSDELAQVSAILTSIDEEANESSKSVSSHPKSVKRTSNSLSASITAPAWISNKYEFRQRQELRLLQKQVTELKEQLELARISSVKKLDLPKWKRAARLELQAKLRAIAENEQLKADIQGSTSFIATMQKYFRKKPRLSMDIDIHSEEWMEYKLAAQASLRIAAIHAIADRQYRRMETAFINAKLIGVGGNVFCMKPIRLANST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W9V5</accession>
    <name>A0A6G0W9V5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycine zipper domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_017132</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000281">
        <property type="protein sequence ID" value="KAF0724123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W9V5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018684"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026268924" description="Glycine zipper domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0724123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="30511" checksum="78F1474FB9B26CC6" modified="2020-08-12" version="1">MRFWMLLAVASAAVMARSPERSHDLRFVMPVASIDFAESRFLESRQSRRLTAPGKANQANNPRGRYERSGFKNGGRVGAAVGATAGVVAGTIGGGAAGTAIAGPAGGVVGAAFGVTSGIYAGMPLGRQAGAKIGAAGGRVIDKVKGHMDAKAKANAPVVAGLSTKSRGTWMPRLKPMPHDLSLGRRNLAEVKRSLRLGRNPRSRRRGQRPLKRPPARARSALASSQERKNRLKQRFETRLRRRQTKCSVRKHLDHLRRGDLAEVRLSSQRERDRTSISAQLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WAU6</accession>
    <name>A0A6G0WAU6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_017682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000309">
        <property type="protein sequence ID" value="KAF0723340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WAU6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014648"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0723340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="195" mass="21573" checksum="FB999B7BA378B188" modified="2020-08-12" version="1">MMMNKEKLEEAVAKSDGRATVRVKMADGSVAEQPRVLITLPTRVGQFVSDETYFVIDLDERWDLILGMGWLEKHQPTINWKLKTISKSLDTNKALGLVSNEPTPNETKSPRRVTLAVEGLATHGHDIALMKAADGQRIASADEDCDGTGDTMTSEDHVDIWGVECDLEKALRDGCAGSRDDPTKKKDATMSWEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WBL9</accession>
    <name>A0A6G0WBL9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_017500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000298">
        <property type="protein sequence ID" value="KAF0723649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WBL9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008980"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0723649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="438" mass="49985" checksum="D17864EFBD8163C4" modified="2020-08-12" version="1">MQSVWITLPVDIVIKIAFAVPDAAGLLAFLKVLRPYNVLGPLEHLFRLSLTHKVWDLWPCLRLAPSTLGSTEQSSYEFIAKYYVKVLVGPGWNDVEWLKAHLNPMAKVAWHIKDLPSTTEIADDWFDLQIPELRLSSMPNALLRWKDLLPRLQYLSSLAIYTDSNNLEDLFELVAKSKHIIDFNIVAPYHRMTASDVVYLTKWFQEQPVREFLWCLKDLGVMDSGLKQDFYEAMFNCPTLDRLELSGFELDDVNFTHLTFAMKSLCLQFCLESSQVVKSMSNRLESSNIANLELTAYYDDDLDEIECLLNTLPCTSIKHLKLSLMPIDNSPTWCCLALLFEKCTLETLTLEIDNLCSAFFQSLATAIQNNHTICELDLSWSAIAVEDLKLLIESMTMPSRQVRTKRVSILSSSLQGMEPSTVENLTELAKERGGEFLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WBV2</accession>
    <name>A0A6G0WBV2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_017373</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000295">
        <property type="protein sequence ID" value="KAF0723797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WBV2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007522"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="181"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0723797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="238" mass="26616" checksum="CECB64E359D628C9" modified="2020-08-12" version="1">MFRGFTALDSSNKLEWGATMRNESDEDDGVRASRTKSLDMNRIRTPPPSLLGQFKASQKKGSARLDAAMTSPRHTEAELDEDIARNSAALQTIRLRRNAARAANSSPRRSGRQTRAPRRLIDDDDFGGATQEEIKRTMDGVEYAYLSLMEVPASQKEAMASDEANKWRDAEETAMKAMVDNGTWRVVPPKAGIKAIKCHLVYAKKMDSAGNIKRYKARLVANGYLQREGIDFFQISLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WCK5</accession>
    <name>A0A6G0WCK5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Pyruvate carboxylase</fullName>
            <ecNumber evidence="3 11">6.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">Ae201684_016734</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>hydrogencarbonate + pyruvate + ATP = oxaloacetate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20844"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.1" evidence="3 11"/>
    <dbReference type="EMBL" id="VJMJ01000266">
        <property type="protein sequence ID" value="KAF0724671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WCK5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001948"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004736">
        <property type="term" value="F:pyruvate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07937">
        <property type="entry name" value="DRE_TIM_PC_TC_5S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000003">
        <property type="entry name" value="Acetyl-CoA carboxylase biotin carboxyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000018">
        <property type="entry name" value="Biotin carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000010">
        <property type="entry name" value="Propionyl-CoA carboxylase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000033">
        <property type="entry name" value="Pyruvate carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000012">
        <property type="entry name" value="Pyruvate carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003379">
        <property type="entry name" value="Carboxylase_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055268">
        <property type="entry name" value="PCB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005930">
        <property type="entry name" value="Pyruv_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006761">
        <property type="entry name" value="PRK09282.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009554">
        <property type="entry name" value="PRK12999.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01235">
        <property type="entry name" value="pyruv_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43778">
        <property type="entry name" value="PYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43778:SF2">
        <property type="entry name" value="PYRUVATE CARBOXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02436">
        <property type="entry name" value="PYC_OADA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001594">
        <property type="entry name" value="Pyruv_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89000">
        <property type="entry name" value="post-HMGL domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 11 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0092">Biotin</keyword>
    <keyword evidence="4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="5 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="18">
        <location>
            <begin position="24"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="17">
        <location>
            <begin position="144"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="19">
        <location>
            <begin position="555"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="16">
        <location>
            <begin position="1101"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="564"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="636"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="14">
        <location>
            <position position="733"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="763"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="765"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="898"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="15">
        <location>
            <position position="733"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-biotinyllysine" evidence="15">
        <location>
            <position position="1142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF0724671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1182" mass="129138" checksum="586EEF9785764FDA" modified="2020-08-12" version="1">MLRRIQRVKATPPSSRMIVRDLSNIRKLLAANRGEIATRIMRAGNELGIRTVGIFSAEDRFTQHRYKADESFLVGKGKSPVGAYLDIDGIVKIAKDNHVDAIHPGYGFLSENVEFAKKCAANGITFVGPTPENLAMFGDKTAARAIAIKHNVPVVPGTEGPVSTLEEARAFIDSGVGYPVIIKASMGGGGKGMRVVNSADELEPNFLRASSEALAAFGDGTVFIERYVYKPRHIEVQILGDGKGKVVHLYHRDCSVQRRHQKVLETAPAVGLSKEVEKAMIDDAVRLTAAANYKNAGTVEFLVDQQGRHYFIEVNPRVQVEHTITEEITGIDIVQSQIRIANGDSFEDLGLVQDRITVRGHAMQCRVTTENPALNFQPDSGVIEVFRSPGGMGIRLDDGPGFVGAHITPHYDSLLVKVTARALQRDDAAHKLKRALSEFRVRGVTTNKSFLQNVLNHPDFIEGVVDTSFIAENPHLVAPSTSTNRGQKMLRYIGNTIVNGPEKALGATGPPPSPMDPIIPVLPTPPARQGKSLRQIYTSEGPAAFAKAVRENKGLLLTDTTWRDAHQSLLATRVRTRDLEAIAPATAIALRNAYSIEMWGGATFDVAMRFLREDPWERLANLRELVPDVPFQMLLRGANAVGYTSYPDNVVYKFCEKAQQTGMDVFRVFDSLNYIENMRLGIDAVGASGGIIEAVVCYTGDVSDPARGPYNLEYYLNYTRQLVKLGIHVLCIKDMAGLLKPQAAKILVGAIRNEFPDLPIHVHTHDTAGTGVSSMLECAYAGADAVDCATDAMSGTTSQPSMGAIVAALQNTELDTGIKSEQINEINDYWETMRGVYAPFESGQKSGSADVYHHEMPGGQYTNLLFQSNQLGLSGQWPAIKKAYATANKLLGDIIKVTPSSKVVGDFAQFLVQNKLTEEEVLAQAETLSFPKSVVEYFQGYLGIPHHGFPEALRSKVLKGRRLPNGKSMFEGRPGAEMEPYDFQEAHRQLCEAYGTDNISELDVLSHAMYPDVFKNFMEFKDKYGSLHFLDTRTFLTGLAVDKEIELEIEHGKTVFIRLIAIGGVSKKDGTRDVIFELNGRQRVIKISDDQASVGKVEKLKASPNVPGSVGAPMPGVIVEVKVQKGQQVKAGEPLCVLSAMKMETAVSAPVSGKVKEIHVLVGESMKAGELLIEIDESGDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WD46</accession>
    <name>A0A6G0WD46_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Purple acid phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_017044</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000276">
        <property type="protein sequence ID" value="KAF0724231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WD46"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001306"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00839">
        <property type="entry name" value="MPP_PAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.380">
        <property type="entry name" value="Purple acid phosphatase-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041792">
        <property type="entry name" value="MPP_PAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025733">
        <property type="entry name" value="PAPs_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015914">
        <property type="entry name" value="PAPs_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45867:SF3">
        <property type="entry name" value="ACID PHOSPHATASE TYPE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45867">
        <property type="entry name" value="PURPLE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14008">
        <property type="entry name" value="Metallophos_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16656">
        <property type="entry name" value="Pur_ac_phosph_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49363">
        <property type="entry name" value="Purple acid phosphatase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase N-terminal" evidence="7">
        <location>
            <begin position="80"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="5">
        <location>
            <begin position="189"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase C-terminal" evidence="6">
        <location>
            <begin position="450"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0724231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="518" mass="57876" checksum="2FFBF07E33B40022" modified="2020-08-12" version="1">MRSTERNPATTAQSRYGTLPLPSARPTIRLSKSVLVVPAGFMAVTCLGFHFLLSGPSFGAPLSPRMRLDAVAPELILVEPRQLHLAFAGTSPGTGMTVSWTTYRKVNDSCVWYGVTADDLSLEVQAEPRSYYADDNYTLFTYHATLDSLTPLTQYYYRVGSRANQTLRSAVRRFKTGRPTLPVHANDTFEAAIYADFGERNAEATVRLLTQLKDRVEFIWHVGDISYADNAFHALNADTAALGFVYEKAYNAWMDALEPTMQEVPYMTTVGNHEAECYSPVCIYSREKQAQLSNYSAYNARFRMPSNGALNMWYSWNHGPVHFVSISSETDYDGAPSNNKGTSVENGHFGDQLSWLETDLGRVNRSETPWVIVGCHRPVYGLKVYKANGKPKAKQQALQKAFEPLFLRHKVDVVISGHQHAYERHFPIAESKPHLEGVSLDRSLYRSPTAPVYIVSGSCGSTDGHEPYVDVAAQTWNVLYDNVHYGISTLRANRTALEWAFVHSVDGATIDHFTIVNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WE88</accession>
    <name>A0A6G0WE88_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_015956</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000237">
        <property type="protein sequence ID" value="KAF0725623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018750"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05930">
        <property type="entry name" value="A_NRPS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd19545">
        <property type="entry name" value="FUM14_C_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.980:FF:000001">
        <property type="entry name" value="Non-ribosomal peptide synthetase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="550"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="1554"/>
            <end position="1630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0725623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="2004" mass="219603" checksum="84B82367BE201552" modified="2020-08-12" version="1">MHINASRDVSRLSSTQLRVILDEFKFTLSQVCDSVFSDGLVSALWELSTSQRQLLQEFCFGPEVPLAHELLHQAFEGRAVAKPDLIAVEYEDERITYGDLNEQANTLAHHLVSLGVGVGSRVAVVMERCLEFPIGLLAVLKAGGSMMPLDATFPSNRLSFMLEDASASVVVSTEDYRAQIEALELEIPVVYIRSADLAASPTQLDVVNTATRNDEAYVVYTSGSTGRPKGVPVLHVGAVNTIMNSNKQVFVEGMRCAQMLAVSFDGCQFDVWSTLTHGATLVLCGFDLLQTLANVDSIFCTPTGLSLLGSPVFYPSLKYVGVIGEAISSSLKNLWAQYVPLLNRYGPSECAIQTHECLLGVSDSISVGQVLPNVNSYVLDNNKRQVPVGVVGEIYLGGICVSPEYMNLPEQTAERFLDDPFLPGGGGRMFRTGDFGRLLPNGRFEVHGRKDSQVKLKGYRIELEEVGEAMMRHPNVTAAAAVVKDKTHLVGYFTPPSVDVEELRALVASYVPVYMVPAVWVPLESMPQNVNGKTDRLALEAMDVVVVVDALETEAEVKMAEVWSSVLGIELSLIGRNTSFFALGGDSLSVIKVVAACRKIGLVMSATQVLKDPILSRVAAMFGSEVVMDWPAVVLPEAMVNEVADVWTESLDLQEYVVYPVTPLQAGMLFSTMSKRSAYVMQYSLLLGDDLTAEMACEGYRRVARQHEILRTTFVSLSSGLVQIIRSDIAEPSVEHVTVPRLEDYFKTDYARGFALGDRSFVRFTIVSAGSEEYAVLTIHHALYDGWSFSLLVEDLLDAFHGRPISSRPSFRGFVDYIQAQDANKTQAYWESELRGVVSSIIAPGSKMLAEEDSRPSVLVEFPGEEISLAAKHAQVTFATLTKFAWAATIRKFLRQQDTVMGEVVSNRNLPVDGIERMLGATLSTIPRRIIFDDEKSVLSLLQTVHTNHTASQVFAHANLVDVKKWSGSDAPQTQVEAYVHHVEVTRGSTSYALEVEVSVAGDTMHINASRDVSRLSSTQLRVILDEFKFTLSQVCDSVFSDGLVSALWELSTSQRQLLQEFCFGPEVPLAHELLHQAFEGRAVAKPDLIAVEYEDERITYGDLNEQANTLAHHLVSLGVGVGSRVAVVMERCLEFPIGLLAVLKAGGSMMPLDATFPSNRLSFMLEDASASVVVSTEDYRAQIEALELEIPVVYIRSADLAASPTQLDVVNTATRNDEAYVVYTSGSTGRPKGVPVLHVGAVNTIMNSNKQVFVEGMRCAQMLAVSFDGCQFDVWSTLTHGATLVLCGFDLLQTLANVDSIFCTPTGLSLLGSPVFYPSLKYVGVIGEAISSSLKNLWAQYVPLLNRYGPSECAIQTHECLLGVSDSISVGQVLPNVNSYVLDNNKRQVPVGVVGEIYLGGICVSPEYMNLPEQTAERFLDDPFLPGGGGRMFRTGDFGRLLPNGRFEVHGRKDSQVKLKGYRIELEEVGEAMMRHPNVTAAAAVVKDKTHLVGYFTPPSVDVEELRALVASYVPVYMVPAVWVPLESMPQNVNGKTDRLALEAMDVVVVVDALETEAEVKMAEVWSSVLGIELSLIGRNTSFFALGGDSLSVIKVVAACRKIGLVMSATQVLKDPILSRVAAMFGSEVVMDWPAVVLPEAMVNEIAEVWTESLDLQEYVVYPVTPYQGDMLYSTTQNWSANVHQHTFQLKDDLTAEMACEGYRRVARQHEILRTTFVSLSSGLVQIIRSDIAEPSVEHASVPHLEDFFKANYARGFALGDRSFVRFTIVSAGSEEYAVLTIHHALYDGWSFSLLVEDLLDAFHGRPISSRPSFRGFVDYIQAQDANKTQAYWKSALDKIVPTIIGSIGSKIIDDDQGVESLKFTLPVEFVSLAAKHAGVTLATLTKFAWAMTLAKHLRQRDVVLIEIVSNRNTPVRGIERMLGATLSIIPCRIIIDDTVPVASLLQKVQADHIASLAYSHASLEDMKMPTTENDDILFDTSILFQQSTPPESAAVHHIIEPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WEA7</accession>
    <name>A0A6G0WEA7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">inorganic diphosphatase</fullName>
            <ecNumber evidence="3">3.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_015856</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000234">
        <property type="protein sequence ID" value="KAF0725702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WEA7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016902"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="INORGANIC PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00387">
        <property type="entry name" value="PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="19"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="223"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0725702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="554" mass="62550" checksum="F321EC640657EC66" modified="2020-08-12" version="1">MSAASFDALIAKTTSQALPALCSGYVYNQPEKNALIWKKRYCVLQDSSLIIFYYDSPEAAEQGELKGKISYSSVHTWDGKPHGFQFYTPTNKCYKLYTDSAEETAKWIATMQEQLNNAPEVPDGEQVPYSRFGASSPIGSPHQGSGLVVNRSTRSDSWRGEDIDVPTMLLELDDLRSEVSTLRSELVLYQKAEKHGDRRPVGGGRQRRGSVLEDGTAIALEPRELERMKQIFSLFDKDNCGRVSANDLKDLHRRLGEPITDEEANEALAYMSPVDGSVDFISFMKWWNEDHKQEPSEAVKRYQAKFKFLKARVANPAIGNIETEMTGPCPSLDFRVHFVYHNRDGSKVRISPWHDIPLYNADGSVNFVCEIPKWTRKKFEIATGEPFNPIKQDTKNGKLREYGWGDMMFNYGALPQTWEDPDHITEGTGCGGDNDPLDVIEIGTKQWHVGSIVQVKVLGVLALIDDNETDWKVLAINVEDHYASKINDVADIEAHMPGCISAIHDWLRDYKLPHVNVFGYEGKCMNRDFAESVVAETHEFWKLLVEERGHSAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WFF2</accession>
    <name>A0A6G0WFF2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH La-type RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_015685</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000229">
        <property type="protein sequence ID" value="KAF0726022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WFF2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001674"/>
    <dbReference type="OrthoDB" id="435402at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07323">
        <property type="entry name" value="LAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF132">
        <property type="entry name" value="LA-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="4">
        <location>
            <begin position="68"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="388"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="404"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="439"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0726022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="497" mass="53372" checksum="479418FC60C2F5CC" modified="2020-08-12" version="1">MDSVLAPPPGLLDIDISSLSLDGTAFQTSQQPEAEPVLDLQGVGSLGSSNSPMASLSPQSPPPAGSTACLPATFLRTICDQLEFYFCDDNLLGDLFLLKNMNMDGYVKLELLASFGRVKKLTTDLEQIKQALELSTKLLLSEDGLSVCRKEPLPYDQTYHGKLARTAIAYNLAEDASIASLKETFRTCGEISYLRLLKKNGVTGRNAVLKPPIAAGETYAIIEFVDADMANHAVLTLSDQYNWRTGMQVVLFDGTTTDKLKQKMFPVDSMDRRRAKSASAVFHSKATPPVHVEAVGEGLADLSEGKVSTGIVYSIRGAGGLITPSRQDGSSISFRLVPDDDGQMDIRQGDYVSFTVGKNKKSGRKYASKVKLEFRPPAITPAIGTSAVWGSSSRYEPPATRNRSATAVETSSSSVAGLSRGRSVSIGQPRPRLPMKSPEATTAGSQHTSADALFRQAAGPDGTRGFRHDSSQQFVQELSGRRRAASSTAAPAMPSFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WG28</accession>
    <name>A0A6G0WG28_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_015905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000237">
        <property type="protein sequence ID" value="KAF0725572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WG28"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021161"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0725572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="458" mass="52378" checksum="4022E51337E4DD94" modified="2020-08-12" version="1">MRQWTSRHDGRTPPRDQIIVWLLERMVVVDGIDGQRLVFRSELSSTPRASETEDAEDLPPFSADEEPSSCHDEEALPSFSSDYLEMPKARRRPSSASSAWSSDKSSWSQDAWRLVLEIRKSKQDIHAANELKRKQAVIADARKQRLLASASRMRTQAKVDKHTKALVHEATRDAIEFHKVLETVEKQAKRETIHVVRTLEHDKRALALGYRQTWKKGAYLGPGPHPTAVYVEKAVDVPFVYDKDGRKHDLGSDVSSRSVLDAAMNKIHRAAAKAGKELMVYLKRYDVMKSGTLAWTEFYQALVDLKVNLTTGQVDAVAASLDRLDAIDYGRFFWQFVHRDAFAKRWKDVTARYSQQELKRMFFSHESRKKGMLMAVDFFVALRDLGFFLTPMEEAIFQHTFDLRDDGSIDFEEFQAAFTSTQVHAAPMPAAPSHLDGVLRDLDEVSRVQRRIESLLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WG31</accession>
    <name>A0A6G0WG31_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase</fullName>
            <ecNumber evidence="4 14">2.4.1.256</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ae201684_015477</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the third and last glucose residue from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide intermediate Glc(2)Man(9)GlcNAc(2)-PP-Dol to produce Glc(3)Man(9)GlcNAc(2)-PP-Dol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>an alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate = a alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29543"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="Rhea" id="RHEA-COMP:19512"/>
            <dbReference type="Rhea" id="RHEA-COMP:19522"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:132522"/>
            <dbReference type="ChEBI" id="CHEBI:132523"/>
            <dbReference type="EC" id="2.4.1.256"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:29544"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the ALG10 glucosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.256" evidence="4 14"/>
    <dbReference type="EMBL" id="VJMJ01000221">
        <property type="protein sequence ID" value="KAF0726226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WG31"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010086"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106073">
        <property type="term" value="F:dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016900">
        <property type="entry name" value="Alg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12989">
        <property type="entry name" value="ALPHA-1,2-GLUCOSYLTRANSFERASE ALG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12989:SF10">
        <property type="entry name" value="DOL-P-GLC:GLC(2)MAN(9)GLCNAC(2)-PP-DOL ALPHA-1,2-GLUCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04922">
        <property type="entry name" value="DIE2_ALG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028810">
        <property type="entry name" value="Alpha1_2_glucosyltferase_Alg10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="298"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="342"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="371"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="408"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR028810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF0726226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="447" mass="51316" checksum="0DDAB60868EC7B95" modified="2020-08-12" version="1">MDEIFHFPQTVHYCHGEWGVWDPKITTFPGLYVVGTAYAHGMEWISHVQISAKAMFCSLAVLRSLNLLFGIGNALLIPRLRMMHEYSSDEGGIATLHGLMISLFPVHVFCCFLYYTDPGALFFVLLTVYFAQLGRRGRLRHGPLSAKNIASVLSAFIAVGFRQTNIIWVLFAIGTEIVHDLETNHFAELYGSQMDEQTTYSYAKTLYSFVVLLVKEFRRVLRLFWPHISVVVAFAAFLVVNGSITVGDKSNHVATFHFTQLAYFATIATAGFGISSLYPNTLLEFAQSVLVSLKHRFVLSMLCLILFSFAIFRFSVVHPFLLADNRHYTFYIWHRFFLKHKFMVLVPMPIYMFCIWYCWKQIRKTCSSLRATVFFIATTLVLVPTPLVEPRYFIVPFVMYHIQTGKQSIGNLAMTAFVFTLVNAATIYVYLYRPFTWSDGTQARFMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WHY8</accession>
    <name>A0A6G0WHY8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_015062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000207">
        <property type="protein sequence ID" value="KAF0726806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WHY8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007699"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0726806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="190" mass="21863" checksum="E9388EB746C348E6" modified="2020-08-12" version="1">MQPHKTKTKQLSIAGMIGMTVFLTLMDIKDLYTRFSCASLLVVEAVTPAVARVRIVEAQNGGCYYIHYPLAKIISYAVLFSFIVRIVRGLATMAWKHHNGKLLSEVEQFWRKFRNSVEVFMNNPLRGNALIRSQAIMSYKFGRSVFIRPFVYLEQNYYIARGMFRMRSDIPFLHNEDANDGADVDTQSYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJM7</accession>
    <name>A0A6G0WJM7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal eL28/Mak16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_014534</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000197">
        <property type="protein sequence ID" value="KAF0727421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJM7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010494"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002672">
        <property type="entry name" value="Ribosomal_eL28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029004">
        <property type="entry name" value="Ribosomal_eL28/Mak16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10544">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01778">
        <property type="entry name" value="Ribosomal_L28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal eL28/Mak16" evidence="4">
        <location>
            <begin position="57"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0727421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="194" mass="21923" checksum="9BDCA5097B7660FC" modified="2020-08-12" version="1">MTVPRCVLGLLTVENKVDWFPLIIGWEKTGWLAGTKAVSIWVCISSRQETKVSNDTLTWLLTKNTSSFLVKGVQPNNDFSRAKFNLLNRHSRKYDGLSANKAVDISLNDKKVVLTTKIAKSSKFPAKAIHTVPLNKAFRANAHTIRAEISRNFYRGDLKRAALARWTQLNRVAKIEKGVLKKSIVKTKRNQFKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJS5</accession>
    <name>A0A6G0WJS5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_014498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000194">
        <property type="protein sequence ID" value="KAF0727477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJS5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021661"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0727477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="209" mass="23001" checksum="74E23A72FA66B78A" modified="2020-08-12" version="1">MASTKPDAAPQTVPTVPIDPGQRSLHSIHEDRDHPHGSPLHPAPPRLFHEEPLPVEPRRSRAKVLTDANAFKPKKKLFRIEPTWADDEVPFGSRRRSILRGPTSAALRRKSCSMSALTQLQKQTSLLEKQAVSPSQSEVDEDDASTIDGDNDNGPSEAIIAMMDAHEELLDAMSMSLGELRAKSDMTEMALNTILDKLNKLEAMLTPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WLM1</accession>
    <name>A0A6G0WLM1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_014005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000181">
        <property type="protein sequence ID" value="KAF0728179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WLM1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017454"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0728179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="490" mass="55347" checksum="7915C83C694B67F6" modified="2020-08-12" version="1">MILDLCGAVLAYMASYITTQDHANTTAQANDSDLDKPTHQDLTDVQTIKKESRLDSVNSINDDHHTACHSKNNSQEQGNTSNEDSTTPVHIVDVAQSTKEDNDFTEEDDDRCPFVCAWEVAHLPARYSTEDKYIFRKEYDHDAAAKHKEAMARASAYVDKILDDEGFVRIEDLHAMRTASVTQDGNHIDAKKKRHREDDDEDIDKSAKRVKFATTTVYSFPIELGECSIATFGPLGMGQRHVAQELFDLSTIAEGDRSHSKTEVPAFVAPPKYDKIPREERLARLRAAGVSDADIHAHAQVALDIARKKSIEKDQMHEMEWRRKLKKRLHRASSRRQRHVAFVAAAVYTFDIGLGGSAISSDGGLPLGMSSTHSQLEIFDLTQTIPTDQQRMEPVSPQERERRLDSADMNPARTTAYKDEAAAIDHSRYIDKVKRFKDNTLDLLARQSELDQRRSCGPYEPNHESGQEKKRRAPDDDDDSEPTNAKRRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WMA7</accession>
    <name>A0A6G0WMA7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_013804</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="VJMJ01000178">
        <property type="protein sequence ID" value="KAF0728441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003981"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003982"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019511"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.10.10:FF:000007">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13975">
        <property type="entry name" value="gag-asp_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Peptidase A2" evidence="10">
        <location>
            <begin position="456"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="11">
        <location>
            <begin position="826"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="12">
        <location>
            <begin position="1493"/>
            <end position="1585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="351"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="393"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="668"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1265"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="674"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="703"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1285"/>
            <end position="1299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0728441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1585" mass="177512" checksum="FC6780C870DF9D5D" modified="2020-08-12" version="1">MLRDVAHPLPEPITSGDSTCRYETDDASIPFDLPPLEPLSDDESDNESGYDEHKTKPTEIHQISSLHSEATSEDQLVTNPLNEPDQPDLSSTPDLTSTLLRSNEIPAPVFTPAQIEAIVTGDFVGISESVADIEDRMMPISSADIEGQIKKIRSRRKDPAHTDLVTAITKTLKRPLTRDEKIIMETPDALDDPDRWLKWFETTLNTCEEARRASRDFRNTHEGRPAIVAAIKCFNTRQLRLFDSAYPDSYPTPISSISMKKPTITPLCPSVRNTASTSAYKSALRTRIRKSESAGKPRLTVRFKDKAEYRYDRLQEAVSIHLSDLKGTRLSGKLWRRIRGATPARRTLISRILKSSPSSPDPDLEPVPSNPTPTVTDPDQARDASETLVATLLDELPSDPTSLSSLGGDRAPPRPHPPDGRDLFTNPSNFPARLLCAIGPLNQAPTVAVTINGVPVSALIDTGAIISVISEECWVRAGSPTLWKSRTNMISVQGQSLQTLGLRTFTIRLAERTELFPFHVMPGTVSHSILGIDYLRRVHAQIDLIQNCLIVPGTSRPLSLIHKSDFVNPSNEHEVSISSITMANPTSTKITIKESLQLPGYHRQMVCCMPLAPLREGTHVLVETTIASEILLVARSLNTVRHGVVWVQVQNPTESEIDWGPQTQIGTATVLPSDYHDGTSIDSTKDDVNPTQTDSKRNPTRTDSTRDPTRTYTDKSPIALTQQIYPGLIAVVTDTPPTKTTNKRTAVKEEIPINWEGSSLNPLQCETIRQLLLEFDLFVTTSKAPGRTDRIKCTINTGNAAPIKSAPFRVSQREGELMEAEIRQYEELGLIRPSTSPWASPVLMIQKPDGSIRFCIDYRKLNDVTIKDRYPMPRVDDLLDVLGKSKYFSTMDVASGYWNVRMDEDSIPKTAFICKFGLYEWLVMPFGLCNAVPQFERLMEDVLRDQLWQSCLVYLDDVIVFSADFASHLSRLRQVLQCLQDAGFKLKMSKCHWGKTSVTFLGHIVTPAGILPNPEKVKSVLKIRPLRNVAEVRAFLGLAGYFRRFIQGFAAISKPLEHLKTAEKFVWTPECDDALNILKRKLVSPPILAYPDFDLPFFILVDACPIAVGAVLMQHQNKKDRVVAYASQAFDSTHQKWITKHDGISEIECYGIVWATKKFRPYIDRRPFTIYTDHGALVWLFKPGSHSTNGKLARWVVHLQSLDFTVVHRPGSKMGCADGLSRLPLEPTLADIESSPTYRYDVSASEWDRQLTIAAIQTRSISKSVSDTRARLVAEQPESDPYPEPPDHDPPDRTPRTDFSHPSATNESEDGFFSSRGEGDSGSDENEETRSIQSARLPKYSRIKYRLPPKLLQVEQAKDLFVQAVKGYLQDNVMPMDSDTLQILTRTGKHFTTDKGILYRRTILKSPLRNPSVIKVPVIPLTMIKTILEICHDSSLSGHFGVVRTTERVKRFGYWRGWRDDVAEYCKKCLRCGAAKGTRPWKQGLTQRMPVYKLRGPFSFLVVDALGPFPLTPTGNKFVLIFVDYFTRWPEAFAVPDLKTSTFIRILVDEIACRYGVPDHLLSDRGTNFVSELARTFTKHSASTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WN65</accession>
    <name>A0A6G0WN65_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_013502</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000173">
        <property type="protein sequence ID" value="KAF0728759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WN65"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005866"/>
    <dbReference type="OrthoDB" id="57727at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0728759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="136" mass="15486" checksum="023F266FE822DB90" modified="2020-08-12" version="1">MLTARVVTEQSHWLFGRFFTCQSWSLQGSVLTIQTEAQEVFKYRVSRGRAWPALQFGIQVQTEDGRCLNASLGSKVKWATWLDAFQNLTPLPKSHSPIKVKFSDDIGIHEIPMLTDEEKALLFFPEPELARPTMCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WN81</accession>
    <name>A0A6G0WN81_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_013371</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000172">
        <property type="protein sequence ID" value="KAF0728799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WN81"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021793"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38696">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38696:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0728799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="238" mass="27076" checksum="4789C16AE5A9361E" modified="2020-08-12" version="1">MSHMQPFTILSLHSSSRIRLSNFPKESTQWMEEAVTMAWPHKTESTGAIDQVVEIKLGGSQWKPGGQDKIQAARLMRNILTVFRMHGYALYTSTNVRNGFGSKDVLFFERPEPCRMSMFIVARHNDNKLRLIHAPVGMVVIVTECIQSNYTGGSVRVSEYMPACHEFKLKSDPWEDGRSPHGRLMLAHLFALLNGHGWRLSATILHSREDEAEETWYFSYEPVAQVVGIVHAPKMDMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WNN7</accession>
    <name>A0A6G0WNN7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_013244</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000170">
        <property type="protein sequence ID" value="KAF0728941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WNN7"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0728941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="84" mass="9631" checksum="192208E972AFF268" modified="2020-08-12" version="1">MDQAHERSCPRTSSWSHASLPLNFRTHRFSFLDCPRPSPYRTSLETYVIRGVLFVARSPSGEIDASPAVQVHLTTIYFSRQDTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WNW2</accession>
    <name>A0A6G0WNW2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_013347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000170">
        <property type="protein sequence ID" value="KAF0729048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WNW2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010835"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="515"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="570"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="604"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="651"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0729048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="772" mass="85823" checksum="744DEAB3DFD1BD8F" modified="2020-08-12" version="1">MANSIDRQARCAKRYTTNAAVHLESLLRNVNWQQLRSCWGASLNAAFAIPLTKLPNGAKWWELVQAVTTSDAEESGYWQSFGATTYTTDWQNYKLIGIIDTFNIENAFGFAYPLTIKHTNGTISFDTQTSMKMYWGFASDLWAISNPSTSLYNCSLIRQDAKFAFQNVSIEEILKQNGTIPASASTNAYSVFRQSIGPFGSVDLRRIPAPKSLIEFALQLRDSLATLCVKSADFCNEYTGLPPVPWFNYLPPSWSRSKTPFLVGGNLLCNDVTSSPFESGMRFLTGAMAACGSTLNEQITLDSVASLPTTRFAAALGAGLVRVNLSIQETDTICPTMILDNVSSTKSLIFPAVQLLLNKSLIPDSNFVPTLQSLAKTAQYDMTNLEIEVAQYGKDPNGNILFLRHQIFDPVYPSFHFMAWILAFEWVSALREVISFQGDIGSITVMSSPNYSVDSLVNPLEIPVNVARYTRYVCLYVTCIVICVATLVTIYLIFNKGQVEGSNLYFINRVTGIIWIGRPFLFIRSTVAFCLLSTQVLALENVNDVWKFTAASNVVNDAPLDRMVRVFKTFLAAGEACWLGYVVSDIFTVVTAQYTSVYAMKSNVIVWGIAALLSWTVPVTHTGTLDRTCDFAQVDFQLVCSSGTVAIGDSMRFMCLVGICLSSTLACYAFERIRDPKRPPPRHNSLLLASSAKFMFASSRWIHHNVYYLDQASAVIDGLLSLRIGNVFYVLDVKIWRLLVIDIPSEERRRLENGHHVHLFSAIPLANSFPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WNZ4</accession>
    <name>A0A6G0WNZ4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sidoreflexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_013349</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sideroflexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000170">
        <property type="protein sequence ID" value="KAF0729050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WNZ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010837"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015075">
        <property type="term" value="F:monoatomic ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140300">
        <property type="term" value="P:serine import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004686">
        <property type="entry name" value="Mtc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00798">
        <property type="entry name" value="mtc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153">
        <property type="entry name" value="SIDEROFLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153:SF8">
        <property type="entry name" value="SIDEROFLEXIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03820">
        <property type="entry name" value="SFXNs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0729050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="325" mass="35350" checksum="0A2C11AF5B984897" modified="2020-08-12" version="1">MAGDGNKRLDLDQPRWDQSTFEGRAKHFFTTTNPLNVLATDEQLDAAKTLVEQYKQGKEPAGTTDEQIWEAKHLYDSAFHPDTGEKNFILGRMSFQVPGNMVITGCMMAFYRSTPAVVFWQFMNQTFNSIVNYTNRNASTGVTTEQLLQAYAAASTMSVATAVGLNKFIAARPKLNAGIVGRFVPLMAVAAANWVNIPLMRQQELINGIAVETADGDVIGKSKVAAQTAVLQVVPSRILMAVPGMVIPPVVIAALEKGPLKRMPALSAPIMVLLTGVCLSFSTPLCCALFPQKSSISTSALEPELQAIVDRNFPETTQVYYNKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WPU4</accession>
    <name>A0A6G0WPU4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_012901</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000164">
        <property type="protein sequence ID" value="KAF0729400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WPU4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016591"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0729400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="80" mass="9034" checksum="CEE29963FD5C9588" modified="2020-08-12" version="1">MTPDLTLVHNFAMQYTPITASGKIMPLEMIGRLFGRSPLGIQHRETYIEQIRTAAEATYVSTHKPIVREVNARMEKTSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WQ89</accession>
    <name>A0A6G0WQ89_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_012866</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000163">
        <property type="protein sequence ID" value="KAF0729599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WQ89"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0729599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="116" mass="13149" checksum="E7CDB06E1C9974BE" modified="2020-08-12" version="1">MLFSCCNLSTLRGDFDDNDEFILRTLKLSPSKLSSSLVSVESIALVLCGCERQLVQHQAVHELLCCDSQLHVSRSATTKIDKPPRSDSFLTPPVVQMSVEKHYYAHHLRSLRYISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WS38</accession>
    <name>A0A6G0WS38_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_012242</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000155">
        <property type="protein sequence ID" value="KAF0730240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WS38"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019184"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF847">
        <property type="entry name" value="PHOSPHATASE 2C, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="166"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0730240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="535" mass="58434" checksum="03065EC9487492D2" modified="2020-08-12" version="1">MATSATGVVERVRLEVETLRRESLHWHLHPLPEITLQALIKSSGGLGIIVDLLPSPELELPEDPTTIELIVGLKYGVNPPVVRCCGTFLHALCDPSTRQMDLPMLKRAERGWSKSYSLSAVLHALRRSFLRRGSDSSLNLWELRSKHLQHLETKYHIDSPQVVVGQCRSAGAASVGARDVMEDAYVCVEQLQCDSASMLGFHPAVYCIADGHAGSECANFLVRTLPSAIGAHLARDKSPRESLWRAFTDVDLDFTKWAVARNDTSGSTCICILFDGLDKLYCANVGDSRALLIRGKHVVQLSRDHRSIDVEEQALVASKGGFITNDRTFGQLTVTRTFGDVDIKKHFGDAISAAPEISEWSLSPTGDVVVVASDGLYAALDNRSVAGIVMTMLAKGEHLQAIASELIRVCIKERRGEDNTSVIVLQLTPEIANAMTPTSSIQEDLEDETPVLLRSTPMTRSVDKLLADLAIHDVVGGGATTSSTTTMPQPQDGLDGSTKRKEKQSAVRRPLVTSETIKSDDELMQFLLDEENFNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WT36</accession>
    <name>A0A6G0WT36_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Trimethylguanosine synthase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Cap-specific guanine-N(2) methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Nuclear receptor coactivator 6-interacting protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">PRIP-interacting protein with methyltransferase motif</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">Ae201684_012009</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78479"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="Rhea" id="RHEA-COMP:19089"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:78480"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78507"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="Rhea" id="RHEA-COMP:19090"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:78508"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78471"/>
            <dbReference type="Rhea" id="RHEA-COMP:19085"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:78472"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78475"/>
            <dbReference type="Rhea" id="RHEA-COMP:19086"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:78476"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="20">May form homooligomers. Interacts with CREBBP/CBP, EED/WAIT1, EP300/P300, NCOA6/PRIP, PPARBP/PBP and SMN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Cajal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000153">
        <property type="protein sequence ID" value="KAF0730590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WT36"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002361"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015030">
        <property type="term" value="C:Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071164">
        <property type="term" value="F:RNA cap trimethylguanosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000066">
        <property type="entry name" value="Trimethylguanosine synthase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019012">
        <property type="entry name" value="RNA_cap_Gua-N2-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741">
        <property type="entry name" value="S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741:SF32">
        <property type="entry name" value="TRIMETHYLGUANOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09445">
        <property type="entry name" value="Methyltransf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="17"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="128"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="23">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00057179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00064494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00079339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00081504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAF0730590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="391" mass="43905" checksum="964F01F7623256DF" modified="2020-08-12" version="1">MAITFRNVFLEDEFAAAKTRKAPAASRPRKGKKKKKKRQRICAVDPSELERAEETIALEQQLHDEMDAVGMAGMLPLSFGSSKRTGGSVVPSYQPKPPAQPIHLTFDENGHAHEVAESTATVLFKQALEEEENERPSEPSTPSLKRPLDDCDEHDATKPQPPAPKKPAHIHPSLQKYWAQRYALFSKFDHGIKLDHEGWFSVTPEVIARHHAERIACDVVVDAFTGCGGNAIQLAQTCRQVIAIDMDPEKITIAKHNAAVYGVDNKIEWIIGDAFDILPHLQADVVFLSPPWGGPEYLNQPKFSLEDMRMGDHNGIQLYHVAAAVTKNIVYFVPRNTDTKQIKLLTEDVCEVEYNHLNNKLKTVTIYFGDLACQRDLNQDHEEDEDDDEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WTL3</accession>
    <name>A0A6G0WTL3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">Ae201684_011730</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="VJMJ01000149">
        <property type="protein sequence ID" value="KAF0730844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015357"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017722"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018491"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020126"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="11" id="KW-0229">DNA integration</keyword>
    <keyword evidence="15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="16" id="KW-0862">Zinc</keyword>
    <keyword evidence="16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="18">
        <location>
            <begin position="276"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="19">
        <location>
            <begin position="778"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="20">
        <location>
            <begin position="1380"/>
            <end position="1468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="287"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1653"/>
            <end position="1706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1722"/>
            <end position="1754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1790"/>
            <end position="1831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1661"/>
            <end position="1671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1802"/>
            <end position="1816"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAF0730844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1831" mass="203850" checksum="04BEA1EC79D3B20E" modified="2020-08-12" version="1">MEEQQRLHLVEVIARYGDVVLAASLPPLQAQVVALQTEVATLTESNNQEQHALQESQANALQLRQQLGQAVAAHPQDAAPATTGEPKKVRVRIDFPPFGKSDNENLMRWISHVSLAAKAMHLDDEGAVAKAVTSLLGRPAEWAHGQLLSLHPGRRLPEQNLVPQERPREVVDYANRLRYIYTLMIDRDSLNEATRVSVFMNGLVESPSRSELFRRIPKTFEEAVEIALKEEFSQASAQGKSAGSDQWDMDVSSMEQFPQREAYRVPASAPPSQRPCFECNQLGHFARDCPRRGGTPRQQQAKTRYPAPAPQGQAQSPRRFGRSPGKCTVGGRRPTGRDKAFPFDGGGSGGIASGTLLCQLGQSSRMVSFEISIAGFSRPLKVLIDCAASENYARRETIASSKAMLDRAASDQDSHAKVRVKLASGQVIVTDRVLITLPTKIGPFDSEETFFVIDLDDRWDLILGMRWLEKHKPTIDWRSKTLSAPSSSDDTPLGVMSNELAPSSALKTQLNTRSRRTIEESIDDDDVLEHNSIQAMSATTEASGELAETSNISMLYDSVAITAYNTARNQVMFQELEGFGISRDGITKIYASHDAKRRRRRMARAAAWSQALAEETVLPARVADTAVRLTADGLILSHCDLEELPRIGEEIVKLPEMSFREFKRAIRSGDIVSIALIQPVDELELNTSSTLDTEVASGKTALSSYMKTWEDLRTNPYYDLLREYENVFPEEVPDTLPKDKGVRHEIDLVPGTKWCVTRQWPLPREQVDHIDAFFEKRRKAGHVRPSTSPHSSPTFCVKKPTGGWRIVHAFNKLNSATIPSQTPIPRKDVIIDGMAGSTIFSTIDLRDGFYQTLMRVCDIPKTAVSTQSGILWEWLVMPQGLSIAPATFNRLVTGKLRPLRDFAPSYFDDIYVHSKKSKTCTDLEVHRGHLEAVLEVLRVSGLYANIQKCMFGVSEIPVLGDYVGINGCRVDPSKVDAINLWPVPRNVTELRSWLGLATYLHKFSENFARPLSNILSKDEPWNWSQDCQSAFDGIKASLVSAPILALPRFDRPFSVVCDASIRGIGCCLMQVDDDGRNRPVSFQSRQLRTAERNYPVHDLELLAIKYALVKFRIYLLGSKPFVVYTDHASLRYAVKTPHISERMARWFSFFAEYNMTVEYKPGRENVLADALSRRPANLGPETTELSVVYHVHSDLYDRIRRGYRNDPALKAIMAQLSENTSRSGPTSTLEWYSIRDGLLLHQPTRTTTPRVTVPCDADIRSELVKEFHDTPSGGHLGRDKTHVTLARSFWWPRMFKSVARYIAACDVCQRVKSSPSVRAPLQPLQIPDDLWAYVSMDYIFGLPRDNRGNTGIWTCVDRASKYLVALPVKASITAEQSANDRDPRFTSKFWTALFSLVGSRLNMSTSEHPESDGQTERDNRVIEDVLCSYAQSRQKTWSSLLPQVEFAYNSSMSASTGFTPFYANYLLHPRLASSMDNSVSSGGRFSWQTSMHSPDWEPSAGDEELPARTIASVKHFAKVRESILLQVQDNIAEAQSRQSRAANKQGRRRNAFALGDQVLLHYSLVPKAILGNAKTRPQWFGPFHITKVISRTAYRLTLPADWQTHDTVYVGKTKAYISQVAPAPELSTAQPHEHLAVQPQAQPNLVDQSLVERVGPRRTTRLPSLQGSSVSRARGPDQKLGSSSPRSSARVAQHEGHREAALSQPQALPQAQALLDRTAPLGLEEDSPGRRDVAKPNDAAAGVAQTAPANDYAPMKTRASAARDLANATDVASTQESAIATPYARILRSDRSVRTFAPSPTRMVTRSQSRQLTSSVKRGRAKVTTRSRTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WTU0</accession>
    <name>A0A6G0WTU0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_011798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000149">
        <property type="protein sequence ID" value="KAF0730916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WTU0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005927"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0730916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="492" mass="56662" checksum="B936F4527F43A9E4" modified="2020-08-12" version="1">MSTMFQNIYRNKIPTSSNVACVHDRQRNTFAMRYIMALPHSIPQDQVQEYILGLPGSQFYGAGPETYVSNFLISNASSRDAMRPWRVCEHEYLAGITIGELCFWMDEEDPTPSTSTPRYNVWAAVFCWETTPLYLSKLCFRSLLTTYVLYLLWTKYYRHYVVLMQNLRCVGLGQEYVHYQIILGDPGYAILIDPFVSMAMMLDIWCGAPYMIMAVLRVSQFHDLWQYALGCIYLSRTVWFAYVCMRGLSALVKWRRWERSFVPVDSGFLAISAYIYGGPLTSLFFTTPVVLVFRRTWGTCLSEEYKDEAIEGILAKLFYTLMMSNLPVIYSRVAIMWIHRRRGRVRVATITRKRSSIRNFSQPSYNDMKAVILLSFVLQKDNVTCHSVGRSLHKLYHKNPRYRAMPLFSLRAADCFVVCINADGIVSQRVRLSLSSWLDRLVNETIFAIPLCTALHATSVGVIDENSCQPVDQALPRGGTIHHGQNNCEWVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WU51</accession>
    <name>A0A6G0WU51_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_011542</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000147">
        <property type="protein sequence ID" value="KAF0730990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WU51"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0730990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="502" mass="56506" checksum="95C00C64A1081AFD" modified="2020-08-12" version="1">MEVRKLSLPAGLVPYSSWNSSLIKMEADSCSVICENGSVVVLTFAPDCQVKARRHLVFGSVRIGRFSQAWSDRNGLVIARDGLLYGFDHDLNQCGQMELPFYAKQMAFYDKTLVIATSNGAFIYEIDVKRNYFILKHNVYPHIPVGVAAFSPCGAWFGIAAIDGRLSFWCTEDMQQIYSVTLNSARPTSLAFSGNFAICVCKDGHVTTFRWSSTTRWAKLLEVNLRPDNVVGYLSSSFVSFWNSTQFAAILHSSYHVDVLDVSTGHFVHRLVFPSHMKFMGMSSFPQFIMLQDTHGSLYYVEWKYGRRVASLSSPSEVEIQVYSGPLGSISLRRQALRLESNSSNNHHTIPIPFVSHQLAKDLRERGNMTTAHGSNFAVHWVQEDLVCLLHGRALYRYSQGQWDSILNPTHILSSVNPIGTCLLILLGPNNVFLWQLDEMILEMLAELPVEVSTLAAKDPQYLHLTFDPERNTIEVQFDSQGSSRIVWQHGLPNVLNGEYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WUH0</accession>
    <name>A0A6G0WUH0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_011653</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the histone H2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000147">
        <property type="protein sequence ID" value="KAF0731110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WUH0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000606"/>
    <dbReference type="OrthoDB" id="193243at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000009">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="10">
        <location>
            <begin position="13"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="11">
        <location>
            <begin position="94"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0731110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="139" mass="14632" checksum="8BAB2C5D91A2973F" modified="2020-08-12" version="1">MSGKGKATGGRGKKGKASSRSSKAGLQFPVGRVARFLKKGRFAQRIGGGAPVYLAAVLEYLCAEILELAGNAARDNKKSRIIPRHIQLAVRNDEELNKLLGDVTIASGGVLPNIHNILLPKKSASEGTKPSKSDKKASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WUP6</accession>
    <name>A0A6G0WUP6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_011518</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000146">
        <property type="protein sequence ID" value="KAF0731258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WUP6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017102"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0731258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="174" mass="19976" checksum="60EE7E556E642D8E" modified="2020-08-12" version="1">MASTIDAHLHWEDEGSLDFLPPVDQDLLNQVSGLNDAFIAPTRPEETSISSTQRRGPKRINVMKVEIRSLQEEKIALEEQLAVLASTHSAKQCQLSDDEKKWKQIAQKQLELKLKAMREHEQLRTLLAEHAIFQREIEFIVLKKPRLMKTRINGGAQATSRQQREETARHPSYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WUZ6</accession>
    <name>A0A6G0WUZ6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ae201684_011411</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000144">
        <property type="protein sequence ID" value="KAF0731348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011727"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="12">
        <location>
            <begin position="862"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="13">
        <location>
            <begin position="1442"/>
            <end position="1598"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="11">
        <location>
            <begin position="1749"/>
            <end position="1811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="751"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="190"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="753"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF0731348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1833" mass="208341" checksum="83A705881E109FAF" modified="2020-08-12" version="1">MQNSDVEKTKEDDNISMNTLATGNFYPNPEEVVQPSAAPNTMNSGEHENAIAGPNFTNNQFHPNEQSLTAPMPGKKLYLPAHRAPMSYAGSMSVREARGPPVVVRSTTNGPSLFQVYNEATRTINQNLHLHYPSSSPQMHQMMMQAQYERQLREYEYQMELQKRDRHVDTIKQEATQFVSHAQETGNAKIRSMEQAMQQMLLQQRQLEDEIKLRQEVLKQAFHEQLQQVQEEKQQWMNDIIAKMQTKNAPSQPFATNMGNPVGNINMDNTSGRLNSKIGVEPQILQHGFQAPGGILLSGYSAPKAPKYNGYTLDARRAFALDYMEYIRSVREVSNDTQTPIACRPIGTCMEAQAKLFAAEFNIQKPVDDITDMEWMAYFQIGLEHVHTQYADIALKIKKSMVMNEKEMDAEKRMDRWIRDYWQILTKNHMLDYGKRHPKAAVKALLEGVRPEGLRESLRQELEHDMKYLRNDVVEFFNYVRGELRHTLKYLRASGQAGYKDREQKVKALKAQEKAKNQNPNGRDAKNVNLDVEKNKRKPVCWYCGKDHRLVDCTLVSEAEKDAIAKKKLAEWRAQENARAERSKSKVLHSVPTNSGTYLASIRGVDGVGAVPTLFDSGVDLCAMVSRGLLEYMQQAATIDLQLVTLEDDKSMWGFGNVPVKVYRHIVLPAIDILTPSGPLALLNVNAWIEETEDMPALTIGRPIMETLGYDTGEFLVQAKKKRSTWNLGAIHAEDMVLGTAVQKALKWYKGEEDPDEDSDDSDEDDDPPIGNDKSCVWNILDSKLKEAAKQGLSNEGMAKLKEILATHIDIFRVNFCGDSPVNVPPLEVRLKEGVMPLHCRSRRYASSQMDYLRKHFDELIQNGLAVLNKHSRWASPPRVVPKKNGEWRMTVDLRGVNALTVPMQWPMPVLEVVMSRLAKTQVYFPLDWFKGFWQLPLHENSREVFTIMGLDGMISPTRVLMGGCDAVAFCQSTAQEVAGARYGKGLEVWLDDTLGSASNENDLLSLLSFYFNQCLQYGLKLNPTKCEFFCKEVIWCGRKISAAGIGYDTNRIQGMSELTAPTNAQELQQFLCALNWKRQSIPEYNKLVEVLAEMLETICATGGSRKKSHLAKFRLADFGWNSDHVRCFENCNAALTKMVSLAHPDPNKAFCLFTDASHEFWGAMLTQIPNASLDKPLLEQAHEPLGFLSGKFKGSELRWSTIEKEGYAVVAACKRWNYLLLRHNGFHLYTDHRNLQYIFGTEAELNVPRYLADKLARWAVTLASFTYKIHHVAGEDNVWGDLLSRWGNANARPTPVVWGDGEDHKPRVRRLVTLPLPNASPLNQEFIWPTQDYIRQVQREHSTAFARMRRHLVFDPVSDVGRLNDRIWVPDDALELQLSLLVVAHAGAMGHRGIVATRTALQNKFVWRGISEDVTTFVNACLQCLCVGDAMVPRPLGEALHAVEPNELIHCDFLSMPGGYIHVIVDDATRFSLLTVHDSCKANDAVRSLQHWFGIFGVAKWWMSDQGPHYKNAVIEKLRGLYGSGHQFSPPHCPWANGTVEVLMRSINKTFKTMLLELRRPHTEWKDLVQLVQYALNNTPSPRNGNRAPITCMTQLPAGNSLAIYTAAEEIVEVQPDMLDKWRTTLFNQLAEARDLLHRDLEQAVAKKRNRERDRRNKEHWHREIRLAIGDYVLVGIVTCKFAHKLQVQWLGPRRIIEALSDWVFVVEDLRDHSQSTHHASRLKMFAASDLNITQSLMDNIAYVEGGHIVERIIDCKFDRISKRWQLHVKWLGLDPIENSWEPLDILLEDVPKLLHQFIADNIKAKANVAAMAKAYTQQLTTERTGTQLSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WVC9</accession>
    <name>A0A6G0WVC9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_011136</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="VJMJ01000141">
        <property type="protein sequence ID" value="KAF0731510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WVC9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007382"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF203">
        <property type="entry name" value="PALMITOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="9">
        <location>
            <begin position="85"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="260"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="275"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0731510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="331" mass="36724" checksum="0F4820C443D239FE" modified="2020-08-12" version="1">MRRNGFQVPFDIFQVTAWIAFPILVGGFYAFFVPFLAKSAAIATGVVYGISAIACVALAVITTSIDPSDRNVLNQVDLQHHQVTEDHLFCNVCTQYVDKKSRHCRICEKCVATFDHHCKWLNNCIGEHNYRYFFMLISAILVLTTVQFVVGIYLFVKAFSDSSSVLVHAASSYGCSGSQQVNADGLCESYAFNLTAIRAVVGVYLVILLPSFYHIGMLVLFHIRLYMLQTTTYDFIIQQRRSQLSQQEGEGDLFACNCRTAPTRPEETPAPALPKSSSTPMLSGFSRPSSIAVHDSSSHETKSPVSPSQREGYEPIETPAEAPTKKNAFFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WVF6</accession>
    <name>A0A6G0WVF6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_011360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000143">
        <property type="protein sequence ID" value="KAF0731459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WVF6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005718"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0731459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="80" mass="8928" checksum="FC946B46A37EB176" modified="2020-08-12" version="1">MAWTFVMICNAGKNGPVTCVNNTDNGNKYFLRASINEVYTIHHYNISTTEECPRDARGVDLSFNEISNISLSLPPAITYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WVI4</accession>
    <name>A0A6G0WVI4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_011161</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000141">
        <property type="protein sequence ID" value="KAF0731536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WVI4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011670"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="564"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="98"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="179"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="434"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0731536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="656" mass="73652" checksum="399931FA3E0C97D3" modified="2020-08-12" version="1">MVPQRPSPRQNLAVSREDTTSQAKLNNLQPATPTIRSVTDMNLISHPSRSARFFDKKKSGLFAKVDAGNRDPETLSMNPTPETRTSLYRNMTALTAINIKEKQHVNTLRQQLEQTKLEVTSLKQELDQVKTEARRYADEYKDAKRPHTPVIKSNQAKQDEQRKIEETHQVEILKWESKCQEMASNHKQLNRVLHRAQETERCLQRQLADGSDRTKALEATIADLRQELQVIARAKLTEDETMKIKAENESMRVKIVEMNRKIDDIQTKERDTRNTLSIKSMQFSQEKEALLREIAHAKDEFAALKASTTAEIDRLHHIINKDEEIKASLDSQIIDLTDKCIALDEAAAGLRKQLDFQSKLLDDKQLVVDQAKLAQSTAEFEVEKLSQSIGALEAGNAALRERLVMVSDVWSVCTTQDPTVLALQQGRRGNNEALAIVLDEKERLQGELDKAKDEITKLTLQIAKATSPAADVVSLQTQLASMLNKKNELLLIMDQLKADYSHLTTEHTALRIAFDELQLQCTALEEVAMDPAVIVLLKQAQLDLNDTVAKLVEAETSSETTFTCLKCLSIFVRPMTLTICGHTFCESCLQSARGGGIGYTCKECGEWSSTDGVFQNNALADLAARFVYRQQTLTSLTNVCQSLQDVFARPAIPVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WXP6</accession>
    <name>A0A6G0WXP6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_010593</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000135">
        <property type="protein sequence ID" value="KAF0732304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WXP6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017383"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0732304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="250" mass="28595" checksum="7310A0360A6F69F1" modified="2020-08-12" version="1">MVRSLRFELSIVGRQEGSGHCDWWGPSFRINWGGFTSRNPSWRGRRELTLSTPFNLTAAIFLESKEDTIAEIPPDIQGPKRHRMRLKIADLIRFKGCFPRGWASSSTYTQGRWCIGRPTTLLPLCIEPLHTRTWPNDLQSLKGWSFSSLLFRYWLDSLDEIPIDGSLHGQRDSRRAAAIARSILRERYPQPPGESPSETWVIVAKQLAVNVQREVLSIVHAKNPQRARTHTGAASGLIKAWRDSYLLDYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WYA3</accession>
    <name>A0A6G0WYA3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_010422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000131">
        <property type="protein sequence ID" value="KAF0732527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WYA3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021570"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0732527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="442" mass="48662" checksum="EA137E64A650A44B" modified="2020-08-12" version="1">MPTPSKQASASSDDDDSDDYVSVSSSDDEDDDENVDKTSNQTPQYPILGARARKRIRPPTTYAKQMAVYIRVCLLHLRDSTKVELSDAEYAAYQEALREHRVERVIIPEKAAVEEAPVERKKKSHKTAPAESSPPAPVLVKVEKPPKKDKPKPIKTEEAKQQQPSSTTTPPAVTGATVTTTSSHNHTADDKTDTMSPADKSPVKRSAPQTSTPEEAPPKKIKVVPSAFQIPANANPKEMDRVRHQASQLQKEGIALKHDGDKKGKMDVAAQGVCYLRASAKFLEQALLLSDLKAMYKALNDSVTASKWGKDSISTLAQTANLVESTVGFFNKSGERRRVALSYKVGAIVMLASYRLQHNMLYGYYSQLHAPGRSPDGTGSSDANQDPMIQRLILKEMGALMRGFEFWRRYEACGMQDVLPDIRDPSTVDMPTFFAALEAELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WYA5</accession>
    <name>A0A6G0WYA5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_010401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000131">
        <property type="protein sequence ID" value="KAF0732504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WYA5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021590"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042655">
        <property type="entry name" value="LRC72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46759:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46759">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="728"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0732504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="802" mass="88403" checksum="C3029CF121EAB732" modified="2020-08-12" version="1">MRSPDEALLRSRSKAPLDQVDVLYLTNCALDVVANLDACTQLHSLYLQHNRLVDLTGLPSLRHLWHVDLSYNKKLHDLSPLTAFPALGYLSLEHCDCTFDDLATLRDIHIVQLQLGGNAPLQVDGQQVYRLKVAALLPNLWTLDGLYITGDHRLLALDQYGELGLMETPDRFGAVSTTWHSSSATNPHGQHLATIVSHQPTHRLARETYRLKALLHFYDIAVHQVNAGISFAPPKTMATAWPVVPTKSLVHLAPRARLNLAILVAARLDFPSIPSFLLLDALTINLLGHVDATDIRAIIEAPSFVSTALLFLLGQQSHEGSLGLPENDRKLWASLPVVLSNFIPPPAPDDEFLFSRRCCYAVILLSRAPSFPAIAKPTDASTVVSAVYKELLPLLEKAKMRVEDLFPDADTGAWISSQRKMGGLLGGTPSQLPWNKHSQDNRTYDRPWASDSPSKAAGSAESMTTTPLSPQPATLDDGQPLVKVGDWVQVRARQYVPIIRVSGDRKFVVLARFQGQQDPPFCGNSTVAIDKLSKVSPNMWKMPLEGSLSKAKSMGKLHRQPQGFHKLGIPRAIGVPNLDLTADDVAEACDAQPALAESKSVQLFTTQSSWNANYVLAPPQMIHAQNYWMEKSNPEEQGWSHIGAPIAEFNQPQLVQPRPLGPKGNVANVLMANYLKERAPSQVADTTPESHSHNNLSEMQQLQRDMAMLLGKTVEDEQSSNVSCFVTETTVQEPRKQQQQSSQQESPHPRPFDIPASTLVALHEASKPKVCFKSWYAESSMAYDDIIILDLGMPCKPSRASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WYJ8</accession>
    <name>A0A6G0WYJ8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_010299</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000130">
        <property type="protein sequence ID" value="KAF0732591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WYJ8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014080"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026266307" description="GH18 domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="2">
        <location>
            <begin position="83"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0732591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="373" mass="39700" checksum="AA365A3761DF5C96" modified="2020-08-12" version="1">MRHFLVIFVTGLGVGISYVTKSGVFAPKGASNSSSGSSKTIPPTVTTDKNGAAITLPPVCTLRTQYLKDNKTCTDCPGFKGGKTFSVFWESQADGCQEFAASDAAKYVTHVYWGFATIDPATGAVSQTLQGNDATLNACIKTFQNMCIKNYVSIGGASERNNFLQLTTSDKWTTFGKTAATLVQKFNFSGVDIDDESGNMASKDGDWLKNTGPQVVGYLSALRSALDDLPQGSSYKISWDEFPSSFDTGCSAPGLDYGRCFPQDALKYMDQVNNMLYNDNSTNLDGYLSNLPSTFGKKVGSDKLVIGGCVGKSGSGVCGSYGDAPTTTQLKNYATTGASNQGAMLWTASSDWRLNKGSNVILMGNAGNYGVKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WYK4</accession>
    <name>A0A6G0WYK4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_010284</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000130">
        <property type="protein sequence ID" value="KAF0732576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WYK4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013898"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF15">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="203"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0732576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="287" mass="32712" checksum="417409BC03251CDA" modified="2020-08-12" version="1">MRRLNSTTTGLTTPPTMNVRNDDESPGLAQGNENDNQLNRKPPVQGTPIELFDRRGRPTPRLYNEQANDPWIVALRAFLEEGAIPLDPHLQKLVVRNSHQYVMQRGIVCRYVTIKTPLRNPELVVVLVIPHTLVEEVLYASHASSLAGHLGLMKTRERIRRTAYWLNWQSDCKEYVSKCPDCNRAKGERPWKQGPMQRMPIYSLRGPFGLVVVDALGPLPTTNRGHKYILVFADYFTRWVEAFPVPDLKTSTFARVFIDEVLCRFGIPDKLLTDRGSNFVSELATTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WYX5</accession>
    <name>A0A6G0WYX5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="3 8">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ae201684_010145</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the centrin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3 8"/>
    <dbReference type="EMBL" id="VJMJ01000128">
        <property type="protein sequence ID" value="KAF0732815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WYX5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013121"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000178">
        <property type="entry name" value="Calmodulin-2 A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000006">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050689">
        <property type="entry name" value="FKBP-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10516:SF443">
        <property type="entry name" value="FK506-BINDING PROTEIN 59-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10516">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="WW" evidence="11">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="195"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="231"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="282"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="318"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="12">
        <location>
            <begin position="461"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="106"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="399"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF0732815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="563" mass="63943" checksum="467CC43ED6FC30AB" modified="2020-08-12" version="1">MKRQSKNPNKLNMPPMSLEEAACKIQSMYRVRMARRRLRELLKAVVERFYDEDSGLYYYHNSKTGQSSWSKPTLLGSEEANLSAMYNVETNAEGDETIVEQLEDAMEEPQVDESNESADPSEKKDNNNGLCEQKERSHMSAIDATPGQDTPAALEATETSNSEREAKEYSPPVEEHSKREKNESDAQQTTSFTPDELLLIEQQFKKFDKDGSGSITAEEMVVIMQAFGDTSTLETIKELIQEVDKDGNGEVNLDEFIHILQKQREKDSHCPSIQLAMLFGPDEILNLRKQFESLDTDGSGEIDEGELAVLMNALGQKVTSAQLKEIIREVDRNGNGMIDFNEFCHIVYNMRNAKQTKFAALLHMGIAKGLLNDLGNVMAATKTRVISWWNAEKIAEEKRLQAKRERALELQRLKREQEERERKIYEEEQARLAALEKERWTPVEGLYHEVLFEGEQYPNKGQYARVHYTAMFENGKVFEASRTRGGAFEFKVGAGHVIQGWDIAIQRMSIGETAKITCAPKLAYGVRGRPPKIPPNTTLVFKVELIAIHEKVKMDQSIESDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WZS8</accession>
    <name>A0A6G0WZS8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PARP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_009927</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000126">
        <property type="protein sequence ID" value="KAF0733105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WZS8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011239"/>
    <dbReference type="OrthoDB" id="19045at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.10">
        <property type="entry name" value="Zinc finger, PARP-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001510">
        <property type="entry name" value="Znf_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036957">
        <property type="entry name" value="Znf_PARP_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM01336">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50064">
        <property type="entry name" value="ZF_PARP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PARP-type" evidence="6">
        <location>
            <begin position="15"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0733105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="96" mass="10708" checksum="50316079CF9C15FC" modified="2020-08-12" version="1">MCASSPWTKSDLPVISVAKQNSTTCQACHERIDVGSIRVGVVFHHVKGYICLDWHHLTCCETPAHLLGAADDLDLLDDKQKQTFQHFVHSQPSLCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X0J9</accession>
    <name>A0A6G0X0J9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_009583</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000122">
        <property type="protein sequence ID" value="KAF0733333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X0J9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006598"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006599"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="288"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0733333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="388" mass="43837" checksum="81F27F6E887031D9" modified="2020-08-12" version="1">MLFQLVRSMLRIRSVLVDCLTAVVLANDGNQTTVEGGAPSLGGIVTRLLETVELLHMMLFLFVVIFLCLCMCAKVRVGHVVDACCRVFLKWGERVQGEFREFERRAPYLSVVLTDYALALESSTNWRNRWSIKRMRNLKKREREMVYISLRRRFVDYRSNHPDPAKAKAIAHAFQLEPETRFPFNEYLNIISGEVLARLIEIDPITWIALEILVVALLFLCWAVGPENEVFVLLISGGVLVANTIAVHAGIHNMRVLLMSPGLFAAAQQRLKELSSHSRVLSAISPDMTTDQIQSIVHVLDEHHTGEITFEDFYHWCSTRIEEYSTKSSKDQLIKEVFDMIDTDGSGSITVDVSISPARQELDGHVGIRRDFQNVGTIAQSRRCGSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X2M7</accession>
    <name>A0A6G0X2M7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dynamin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_009209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000118">
        <property type="protein sequence ID" value="KAF0734036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X2M7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009582"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051943">
        <property type="entry name" value="TRAFAC_Dynamin-like_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43681:SF1">
        <property type="entry name" value="SARCALUMENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43681">
        <property type="entry name" value="TRANSMEMBRANE GTPASE FZO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin N-terminal" evidence="1">
        <location>
            <begin position="46"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0734036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="522" mass="58990" checksum="F33D2A9D386BA044" modified="2020-08-12" version="1">MEDDLKASGELNRMIQREIETMLDRLEKLRQQSKFASFSKVHVPMVLVLGNHSSGKSTFINHMLGQEVQKTGRAPTDCMFTVLMGGKRAERLDGYALSRDNKFGFQDIKGLFGADFVSQVELKVLENCTLLDTTGMMIIDSPGMIDPPGTTQTRDRTDMDRGYDFKKVVRWLAERADIILVMFDPDKPGTTFESLDVLTTSLNHVNSKVRLILNKVDDFKTVHDFARAYGALCWNLSKVIPRKDMPFIYTMYVPVNGAPDNQLKTEEAMLQTLLHTEFDGTRGEILREVQRAPDLATDNMLTAFKSLCAKLKMHVTLIEACQKEYKWIENLWHGITMGLVAAGVGVSVMYIVRTWGVTDGTPAIQSSEASSTQPTWKQEWAKQVAMSKRAFRWVEFLKLTGTSAAASLLSWKAGEKTLAKMQADILSWLPTVFASTYASRLIKSDRTHDETIATYNSILPGLEMALTQTRLDGFEPFSLPEKSYLDDVLATHVPRLDRCVRDRSGDDYAYLRFKHYEKPSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X2U1</accession>
    <name>A0A6G0X2U1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tubby C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_009024</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TUB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000117">
        <property type="protein sequence ID" value="KAF0734156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X2U1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003295"/>
    <dbReference type="OrthoDB" id="8775810at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.90.10">
        <property type="entry name" value="Tubby Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000007">
        <property type="entry name" value="Tubby_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16517:SF7">
        <property type="entry name" value="PROTEIN KING TUBBY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16517">
        <property type="entry name" value="TUBBY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01167">
        <property type="entry name" value="Tub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01573">
        <property type="entry name" value="SUPERTUBBY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="Tubby C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubby C-terminal" evidence="3">
        <location>
            <begin position="107"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0734156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="386" mass="42797" checksum="7D25AFB3272DDEC9" modified="2020-08-12" version="1">MADFASRKNSLSISTDFNNGMPGGDGPKGESTAPASGDVSFFDKAAMLLANKLLKDDDAPSGNPTWGSVIKREKFQDMDLLESGNAREYMSEESLSPTNAKTWTYSTVHRINKTQYKMFWNNDQFLLSAKQHNGIFYISQYEHFGESAAPDGTSSMPTSHYCAVLKKTTNNSFKLYNCGCEGCDQGFSKYTCSNDHETSSFGFTEESGEGADRQLLADISHYTKLVSGISSEMRCLNVVIPAVMEDNRSRVIWCPRMCRGDTPTGGTPRTSIKTELVTSPSPHSKKTKFTFETPVSDRVKLVSKLPSWCSEVNSLIMKFHGGRIREASAKNFMLVMDDDDDKPVFQFGKFSKSKFSLDFRYPLAPVQAFAIGLSSCSWSAKSKLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X3C4</accession>
    <name>A0A6G0X3C4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_008973</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000116">
        <property type="protein sequence ID" value="KAF0734290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X3C4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001552"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0734290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="127" mass="14511" checksum="82D8882FF7C5237B" modified="2020-08-12" version="1">MRKNNNNSATASSSLTASGKRMSNYGSTYDPTAHKLMATSDKIELTKQTIAEADERAKHVLVDLEAQRAQFTDMKEMVNQTKSATTQATAYLKEIRARTIRQKVFLWSIIVALLVADIWLFYWFFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X4F4</accession>
    <name>A0A6G0X4F4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U3 small nucleolar ribonucleoprotein protein IMP3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">U3 small nucleolar ribonucleoprotein protein imp3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_008586</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000105">
        <property type="protein sequence ID" value="KAF0734809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X4F4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005332"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000006">
        <property type="entry name" value="U3 small nucleolar ribonucleoprotein IMP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_uS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS4 N-terminal" evidence="11">
        <location>
            <begin position="3"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding S4" evidence="10">
        <location>
            <begin position="107"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00069727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00072223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0734809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="183" mass="21783" checksum="4C819E7226C0FFE4" modified="2020-08-12" version="1">MRQFKYHEKKLLKKVDLLEWRNENNLHEIKVMRRYRLPNREEYHKYNKLVGDIGRVVARLKKRPANDPFRIKTTEKLLEKLYQMGLINGTKSLLKAEELNVSSFCRRRLPVVMVRLKMSENIKEATTFVEQGHVRVGPNTVTDPAFMVTRPFEDFVTWVDSSKIKRTILKYNDKLDDYDLLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X4W6</accession>
    <name>A0A6G0X4W6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Stress-response A/B barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_008550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000103">
        <property type="protein sequence ID" value="KAF0734888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X4W6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020339"/>
    <dbReference type="OrthoDB" id="42919at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044662">
        <property type="entry name" value="HS1/DABB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33178">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33178:SF10">
        <property type="entry name" value="STRESS-RESPONSE A_B BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07876">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00886">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stress-response A/B barrel" evidence="2">
        <location>
            <begin position="2"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0734888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="104" mass="11850" checksum="9B013C7906CE38F2" modified="2020-08-12" version="1">MVEHIVLVKWKATADPAKIAEVQEATIALKDKIPGIIDVAFGEDFTKARSLGFTHGLVMRMDKKETVKVYEQHPEHIKVLKKMIPLAEKFLTIDFESPRHVSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X589</accession>
    <name>A0A6G0X589_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_008486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000102">
        <property type="protein sequence ID" value="KAF0735015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X589"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000062"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33487">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33487:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0735015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="392" mass="43740" checksum="1C378B9A6BE0611B" modified="2020-08-12" version="1">MNMTLASIQTDMTYLLYDLEYLLVSSIDGIGPKMITTRLATECNRNGYTKCILNLRTAIHDKEDQRKLFLEAMATLDDMKHHDELLLTYVPEKYSTLKCERPSAPAIISRGTTFVTLEVLQYYNEKAKVAYYCVYGKETGAGTDVSLNNMEYPGTGSIIFPSPQPLLATISGLQPNESYVFAVAAFDANDQASGLREVVFIRHKWITGYDGQHGTDCAPEGEKPKKTTPRDDKAGAQSRCDEVLISNTSPAKAFVELKTHFSDHKDFVKFACLLLDLQIRSGEKIPKGVLKEVCWQPSLRLSSRAIEVLVQLGASQLYQRENENIAGQIIENIEQTSQSSEGSSRLKEIDVQDMDVYLWSGEVYFLSGYSLVDTNSPLMIDASVALITLYEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X5N2</accession>
    <name>A0A6G0X5N2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Deleted in lung and esophageal cancer protein 1 Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_008213</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000100">
        <property type="protein sequence ID" value="KAF0735298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002479"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033304">
        <property type="entry name" value="DLEC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059041">
        <property type="entry name" value="Ig_DLEC1_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46348">
        <property type="entry name" value="DELETED IN LUNG AND ESOPHAGEAL CANCER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46348:SF1">
        <property type="entry name" value="DELETED IN LUNG AND ESOPHAGEAL CANCER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23277">
        <property type="entry name" value="Ig_Dlec1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23316">
        <property type="entry name" value="Ig_DLEC1_6th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Deleted in lung and esophageal cancer protein 1 Ig-like" evidence="2">
        <location>
            <begin position="262"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="796"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="800"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0735298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1696" mass="183936" checksum="DB4667EB90CFE0B5" modified="2020-08-12" version="1">MSTDDNQKDEDVVAVGSISNVLRRAFRDYYVDDVDAAWLLEQEHPYVVYATDQMQAIDANLRDKVSQASDLMALLDQRRVEAASKDEQQARELVAQGLVVKAQIPLGPSNFRLDRNELAHFGALASSLVLARDLVADNHARMLDRSGNGPSARIQAAKHAVEVPGYLKTTATVSLRKKATLHPPSTAPEEEEEYITEDLADAGPPPESPKRPKKPKPQPQLSIDQVDANAKILERMQRTLAFRRNPRYDKSNHDINEASPPFQVEPMPVEFTDYDMGGVYEQLVLVKNIGAISGRCRVLPPATAFFMLASVCFPDPSGLVAPGLSCHVRIQFAPDTRADYLDEFVVFVETPSGVDVPLQIPLVARRTPPLLSIPSTLVAASCLVGGTSSTVIPCRNDGGQGRFWCLSQADWTDSFTSMTASWIDRIQALQAVELDPIVELGPFTLSPCDFELARDATIDLTLTYTPMGVGDETATFFVVCDNCLVKSFQITGRGCLVELEPIAINGVSMEHSSSPVAACLMRFDRLLFPPIVACATTTQGFQLMNHTPLDLAFEWQLDGAAADGGHDMAFSVSPAQGILDRHACSSFVVTFAPLRVDSFAAVATLTLCNVPPTCLAFVEPLQHLPLTSVAAMTLTLEGAARAPRIELSPWLVALPEPSIVDRAINSAAETIAMINPESIPVAFDWGDHAPVSPRRGTLSPHAQVAARLTYAPSHPGSFGFPLECSIASSPAASVARVEGHVARPRVRFLAPEVDFGLVRVGTSAVERLIFQNDGLATVRFQWRHLEAAVATKTLPRPHSNESLVSASSKTSNETGDTSAPPSLKCTVSFSPDGGTLAPGQQATVEITCVGGTSPERFRGAFQLELLDQKNPLDRFVCIAARGEIQCPHVYLSQTQIQLGTTYLGVSVQHTIELVNVSNLAAPFKWSEPQLRHASKPYSVEISPQKGILGSKETLPIQMTFTGRAPGYTEVLLACQVQGMRECLGLELTTLQKGLVLSYEVVDEAKSVDFGVVSPTAAVSSSLPKLHFGDDVPLFERKTLRLLIRNHSGITATVAVDARKYNAAPCDATSTTNALEPREHAFQSQAGKAYKSNQATQRQDRLRLSAGLGVAFVCSPSTCVIPPWSHALVEIIALNNMAGRYVDEIVVKVDTMPPVRLSATIHVVGCPLSINANCVGLKMPLPAIGSPSFPVLEFGLWPLRADATTRRIQIINTGPIPARLTWKLDEFPDETMPARVVDVALTVQPDGMVQVRIRPYVPTQSAVKLPFQIDPIDQVIPKHGHANFSVSFLPQTWPQVGLVRALLVADADWLHGYMDGRPESNLSMASNGSNQSSAKSLLMGAVGKAMQAVRLTNAMGKAKPTGALHWRSPACVKLGMSSELLHPVLHWDKTTPSLLIFTTWATHDAAHPTRFQTIQLVNRLGTKLSFRLETTGAAFSIKEATTSGSHHPLSASNLPSTQRSLTFNQYPTPSFTLAPGQSVQVQVHFQAPDHDNDEAPLDGRRRLNSSMVQVTNGQLDVRYSQGSTQTIALQGRVLRPRVVLAPSQFKFGRVHCTQSTNVTIYLSNPTEVDARFAVQHVPQVSTLTTDDPAVFHMAIRNGVVRGPSLPLYTSSALVPTPSPGYAAGIHRPFDVVVTFAPTKPVKYKSRFHFAVHAGQGFDLVLEGEGTLVEQTQPPGSRKLPHAAPLRHSHYVLGKVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X6E1</accession>
    <name>A0A6G0X6E1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_008065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000096">
        <property type="protein sequence ID" value="KAF0735498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X6E1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004873"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169:SF2">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0735498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="26708" checksum="912394B53C44A441" modified="2020-08-12" version="1">MFLCAVARPRYDESTGRWFDSKIGISSFVETVPADRTSRNRPAGTIETKSVAVTKAVYREYVINKVLPAVRSKWPVSMRKMPIFLQHDNASAHGVFDEAFQAQCNVDGFSICLQFQPPNSPDLNVLDLGFFRAIQTLQFEKEATNIDEMLRAVDEAFLEVDITTLENVFLTLQSVMISVLEVRGYNNYKMPHLGKAKQRRVGQLPVSLPVSRGLVAMCVEEIEEYDMQSQFESLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X732</accession>
    <name>A0A6G0X732_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_007962</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000094">
        <property type="protein sequence ID" value="KAF0735645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X732"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003844"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0735645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="328" mass="37612" checksum="2645AF828E2AA652" modified="2020-08-12" version="1">MEELSKGVTKSQPLGLTLGFFKRFIEIHGGRDAFENLTTGAVCARFLLPWSFVRQASDVVCQPCLVVSYLDVVDALDDFFQENGLDDSVAVWFCTFCNNQHEIQDQVYDFDHWFGIFRSSLRSVGNVVMVMSPWNDPTTLRRTWCVFEVYASVVENARFEIAMGRSQKASFLQDIQDDGAFYKMLSTIQSEKSETTIPSDRDNIFQLIRDEVGFVKLDRMVFEVLEKWMLPTVSQQSEEAFDEISRAAWLLVKGGLLRGKGHYGDAVDIFYAVRIIYLRELGIDSPEAWNDVASTKLEEGTALEEAMTMFEDVLKFKVRHYSKDHEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X741</accession>
    <name>A0A6G0X741_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SAM-dependent MTase RsmB/NOP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_007817</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000093">
        <property type="protein sequence ID" value="KAF0735812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X741"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002071"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009383">
        <property type="term" value="F:rRNA (cytosine-C5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1170:FF:000001">
        <property type="entry name" value="Ribosomal RNA methyltransferase Nop2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1170">
        <property type="entry name" value="Sun protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011023">
        <property type="entry name" value="Nop2p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023273">
        <property type="entry name" value="RCMT_NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="RsmB/NOL1/NOP2-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00446">
        <property type="entry name" value="nop2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807:SF30">
        <property type="entry name" value="28S RRNA (CYTOSINE(4447)-C(5))-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02012">
        <property type="entry name" value="RCMTNOP2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="11">
        <location>
            <begin position="222"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="518"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="30"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="549"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="605"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="637"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="439"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="314"/>
            <end position="320"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="382"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0735812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="665" mass="75384" checksum="F8FE923C66E8ADED" modified="2020-08-12" version="1">MAPPARKSNKYEKVAAKQTKKAPAKPQIESESEEEEVQDDNFDGESDQEDDDEEQEDDDVEEEDDDEVDDDDEPSKGFSDANSKWLKPKKGASNGDDSEDDEDDDDDDDETDFEKKARRTAAREREEAAEAEAELQLNLKNQATYSLEDDEDPTGEDAGQVYERIKDIVEVLAQFKERREAHRSRSEYVDQLTTDMASYFGYNRDLMVLFLQMFSPAECLEFIEANEQPRPLVIRANTLKTRRRDLAQALIQRGVNLDPLAKWSKVGLKIYDSPVPIGATPEYLAGHYMLQSASSFGPVLALAPEPNERVLDMCCAPGGKTTYIAQLMRNAGSLIANDLKKQRLKATVANLHRLGVKNCAVSNYDGRKLPTVFQGFDRVLLDAPCTGMGVISRDPSIKTQKTEKDVQRLAHLQKELLLAAIDAVDAKSSTGGIIVYSTCSVMVEENEAVVDYALRKRAVKLVDAGLEHGKAGFTRYQQQRFHPSLHLTRRFYPHVHNMDGFFVAKFKKYANALVHKDADDDDNDEEEMSKKAKRKLKAQQRQASSDVDAQVEAEDSDKEEDDEDDEDEEEDKEEEEEDKEQDDGDEEEEEEEEDEEEEEEEVKPTKPVAKKQQPQKKPALAKKAAQKGPSNNNSRQKPNDNKPKQKRFIDNKMAQARMKKRQKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X7C4</accession>
    <name>A0A6G0X7C4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Death domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_007864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sel-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000093">
        <property type="protein sequence ID" value="KAF0735860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X7C4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012635"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050767">
        <property type="entry name" value="Sel1_AlgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102:SF160">
        <property type="entry name" value="ERAD-ASSOCIATED E3 UBIQUITIN-PROTEIN LIGASE COMPONENT HRD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102">
        <property type="entry name" value="SEL-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0735860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="34895" checksum="13013A650EC20923" modified="2020-08-12" version="1">MLRRWFGSIRPTTVIDEEIQEIVRKLRTMGSEGAAVLITPDHVSQLAETTPPARLYQMGQAIFENSRENIAQSLLLWKAAMDKGHLNAKFSYARCLRDGTGFPKPDPITATALFKHLYEAKNAWGTYAYAEALNSGEGTRQNKAKAFELYLACAKADLPPAYMAVANMYASGQGVEKNTAEAVVWYTKASSKGDAHAKSILGDWYYNGINVNQDIPLGLELRRGAASAGVPNALFNMGCLHQAGENVDKDDSVAYQLFQQAAMKGHAMAMFNVAIMLRDGIGVAANHDAAKKWLEALAPYDIHAKEMLDEMVKSNEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X7F8</accession>
    <name>A0A6G0X7F8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_007837</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000093">
        <property type="protein sequence ID" value="KAF0735833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X7F8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011439"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0735833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="347" mass="38667" checksum="254400768828E2DF" modified="2020-08-12" version="1">MSSIDTLVPEAAPAEETEEEFLASHKHALLLIQDGQVAEADRYLQARGYTHRLSTAVLRYPFEGDVVAPHADPIDPRPFVCAADNALPASMLAFMQHAFSSADSPFWEAHQYSVSPPSPYFSYVHDLSAPPQMGLDDVVHYLKALAVKRFPAVKRATFAEWWTHCRPHPSGHQFHFDSADEGRGGVRNPIVSTVMFIEAPCGGPTCVTDQRFGFSSLGRHGWMVHPKENRFIVFNGKVLHGVVPGRGEPKSTHPSSRRVTFMVAFWDFDVRQGPVAPGERPGSAMPLNWDEPADWKRRLKPRVAADDAVPDADIDVEPVVLPNVWERTDGKPLDRKMPSYDTCFQGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X7L8</accession>
    <name>A0A6G0X7L8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_007895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000093">
        <property type="protein sequence ID" value="KAF0735893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X7L8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020118"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF37">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="118"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0735893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="360" mass="40667" checksum="B004FEDB3E905B11" modified="2020-08-12" version="1">MESQLALIPEIPPQVPFDMDQLDYGEVGQSEEERQQMREVLDKYKANFIRSGNGLPPPARGTVCDIDVGSAKPIAHRPRRVRPEHLQKLFELLRGLLSYGLITFSNSQWASPIVIVLKKGGSDIRLCIDYRGINDLQELMRSPMPTLDAMLSGFHAVQWLLSLDNASGFWVVRVTKRARLISAFICPLGHFEWTRMGQCLNNAPMIYQRMITNALYGFVDLPPGMNEVDEVGEPRDMFQIGHVRDASSMPAPANRTSFVDDISDGADSWTGVVDLTDRILQRLTYFNISISALKSKFGKTVVDFLGHLISREGIHAKPRGLHQILQMPFPKSLRAMQSFLGSINFYSRFIEVWCLQRAQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X7Z4</accession>
    <name>A0A6G0X7Z4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_007199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X7Z4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020554"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39474:SF1">
        <property type="entry name" value="FUNGAL SPECIFIC TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39474">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0736176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="102" mass="10883" checksum="E36528EC9659DCEE" modified="2020-08-12" version="1">MHPSTDAGNDKAPEPILALPSSTDSADDSGNKLTVGGASLALDHLGPIVVQPDGSLMRITDWETKTEQEKKTIARVIAKRNKERLEALQAAETAVAMNTEMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X8Y8</accession>
    <name>A0A6G0X8Y8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">inositol-1,3,4-trisphosphate 5/6-kinase</fullName>
            <ecNumber evidence="3">2.7.1.159</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_007521</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ITPK1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.159" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X8Y8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020091"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052726">
        <property type="term" value="F:inositol-1,3,4-trisphosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052725">
        <property type="term" value="F:inositol-1,3,4-trisphosphate 6-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047325">
        <property type="term" value="F:inositol-3,4,5,6-tetrakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032957">
        <property type="term" value="P:inositol trisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008656">
        <property type="entry name" value="Inositol_tetrakis-P_1-kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040464">
        <property type="entry name" value="InsP(3)kin_ATP-grasp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14217">
        <property type="entry name" value="INOSITOL-TETRAKISPHOSPHATE 1-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14217:SF1">
        <property type="entry name" value="INOSITOL-TETRAKISPHOSPHATE 1-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05770">
        <property type="entry name" value="Ins134_P3_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp" evidence="11">
        <location>
            <begin position="26"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0736511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="98" mass="11037" checksum="BDB25400040ED5AA" modified="2020-08-12" version="1">MPVVEFDTQKPYPTASSFAQDPSQTNPSSLSTPSLEADVIAIGRAIQKQAKLTLFGFDVIRSSQTHELMVVDVNYFPSYKELETFDHLLRKHILHTIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X9E9</accession>
    <name>A0A6G0X9E9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_007076</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000088">
        <property type="protein sequence ID" value="KAF0736626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X9E9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018299"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF206">
        <property type="entry name" value="HSF-TYPE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="5">
        <location>
            <begin position="58"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0736626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="217" mass="24637" checksum="5C833DBF64C28280" modified="2020-08-12" version="1">MHTSNVDAALSEFLLEGTFDAASSSGWWSEDSIDETMSRKSSMDMSTNDLDAINNAERTTKYLDKLYCMLEQCPTTIAAWTRNGTSFVVYNSDAFEKTIIPQYFKPVKFESFARQLNSYGFRKAKHHVNRSIVYEFRHSNFVRGQSHQLESIHRRRRVRRHPSPKAPAPPATDANVHAALVDLMGIVRTLKAELAETKAMVQSYLVAQDQIVQVTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X9K7</accession>
    <name>A0A6G0X9K7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_007155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000088">
        <property type="protein sequence ID" value="KAF0736708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X9K7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010799"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="69"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0736708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="370" mass="41502" checksum="D6F29C4019C1F849" modified="2020-08-12" version="1">MLTNVVPYLTGFRKSAGFGSWREIFHRAVTHEQSPNISLVRKMYAKSNSVTPRGSFLSTASPRASSSINLDDVNIKTWILNTSVIDNVTYYRILVRRGTSNVIQETKHRYNEFLEFRDSLLELFETMPTCPRCINIAKAVASFDFPKKHYFSARSKVVINYRMHAFRNFVSMLVTKVFNPSPKCPTCGGKVITAVLRFLLQNATILPENQIPRDGLMQRSETPSSTRSTASSAGFQNFPRSVSAPLNSQRQAVPQQPPASAPTAATNGGPLPVQPAPQSKFSSLHRYSVPQEEQEDLYDDFDDDVEKVRRESRQQVMFDSFLHDKDSVKERGMSAVSDTIPDAPELEGDNTSESSDEEEIEMTGVFNAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X9R6</accession>
    <name>A0A6G0X9R6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_006968</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000087">
        <property type="protein sequence ID" value="KAF0736811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X9R6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019092"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000298">
        <property type="entry name" value="ATP-binding cassette sub-family A member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF36">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="456"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="490"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="521"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="589"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1038"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="676"/>
            <end position="895"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0736811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1091" mass="121609" checksum="9E6CEAA54513022E" modified="2020-08-12" version="1">MGETTNSPPVIEAVPPKRRGFTTTLLWKNFLIKRKHPIKWALEILIPLVLLVLLGYLKSLRDDEIIPEGWSNGAGSTESLYMKAINVGNPRVYQTEVTVSGLLLKMATDPWDSRKEDLYMTEEERKVCMAAAFGGNISSDSSSPYAWPSMCRDYIVPRKLAIVPDNDFTRKYFLQTLSEWYPRVPLNANQTLVVPSIADSVKFFADEASLEAYVTGSNYGKGFTSPTIAAAIVFTAMPPTLGSVGIIEYKLRFNSSATQDEVIGDVPSTNQSPYEPFQRKMKAEEYLTYARDGFMAYQTLVTRFALCVPDWNTQTKTTTANCTNPNSTMASNLDAEAALATILLDSDTNLDFQAHSYTIATKDKFNLTAIPKPSLLALARPLRQMPQPIGGASVFVMPIQTYKSVPVLDTLSSLLSIIVLLSYLHILSSVLVALISEKETKARELLKILGVHEFAIVWSWYIMYGILFILAAILQMVVCKLMLFQRSSSGILFAFFLLFGWNVMTYGYMVSAIFSKARSGAYLGMIGFFAMLLVSYAFSDTSSATSKHTACIFGPVAMAFGVKTLAKAEGNGVGLTTSNWADDINNFKFITTLYMLIIDSILNTLLGMYLERVIPKDYGVTEKWYFPLLPSYWRTKFTKTTPTTQHETSVEVEIHNDNFEPVGADLKQQERTGEAFQIKNLRRVFSVPGGEKMAVKGMNLTMYKNQITCLLGHNGAGKTTLISMLTGMIPVTSGDATINGLSLSDNLSQIRQSLGMCPQHDVLYPELTVQEHLMFYGKIKGYTVGLTEKRNVYSNELSGGMKRKLSLAIALLGDSKIVFLDEPTSGMDPYSRRSSWEIILNNRPNRIVVLTTHFMDEADILGDRIAIMAEGELRCCGSSLFLKNRYGAGYNFFLVKAEHCNTSALVDFVQGHIGESTKVLSNVGTEISFQLPLDCSHLFAKMFAELDDKLDNLGVLSYGISVTTLEEVFIKVAEIGDEHHQHTLQTQQKKELKMNIDGSRSECKLTDIAPKTELAMFFIHFKALFMKRVRTAKRDKRLVFFGTILPVVFLVLGVALLKGSSNNRSDPPISLTTDSIPYKTNTPYRLFQEYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XAZ6</accession>
    <name>A0A6G0XAZ6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_006436</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XAZ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011162"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019332">
        <property type="entry name" value="OSCP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21439">
        <property type="entry name" value="OXIDORED-NITRO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21439:SF0">
        <property type="entry name" value="PROTEIN OSCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10188">
        <property type="entry name" value="Oscp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0737260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="377" mass="41602" checksum="F32A47FCE4941BB9" modified="2020-08-12" version="1">MDGPMATTSGAMLTMPMILINMGGEMLYVLDQRLKAQNIAGDKSVKVLVDVVKTMYNTKFISELFKPHHMYSNVSTRQIFDRLAHSSIMRLNQSSMDKLYGLMRMGFKYNILACSSADQLVQVTMNHLRSIKEIVPLEEATVLIEDAIVLTANTYGNMSHGNFLLLKQSLCRFFQDVRIKVSLFLQSEIQNGDGSFVIRSDGPTATGGDVPGTIRYYSSSGKLEDDDTVELHNARGAVPYDDKPILSRDPSLCPYGENLYIPNAKPGLKSVKTGEEMAADAKKAGAKGTADSDKAPAKQWKATASDGLNLLADLLGTKESADVKPWKINLFSDEPFDEDDKVLDPEVETIMIDAMSDRKTTKSLLDDFDDKPKAQGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XB60</accession>
    <name>A0A6G0XB60_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_006561</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XB60"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021762"/>
    <dbReference type="OrthoDB" id="765884at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45188:SF2">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45188">
        <property type="entry name" value="DNAJ PROTEIN P58IPK HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="11"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="79"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="193"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="239"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="4">
        <location>
            <begin position="370"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0737396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="518" mass="57431" checksum="FEEA2C02C2C78A1A" modified="2020-08-12" version="1">MEFGGNNDASAEEWKTKGNDLYKKGDYRGAIDMYTMAIELSPTTAAYYANRAAGYLMLNKYHEAIGDASRSIAMEPTFLRGYQRKAKAQVALGDLEAAIKTYQAGLMKDPNDPTLMNDRRSAEIAMEKIKRGRDHVKAGKFREASFCFDSALQICTHSNDLKKWRAEALIGCERYDEAFAVLTQLMRSDSSSPDVLFLRAQCLYFQGEFTSAIRHLQEALRADPDNGKFVKEIKRIRALDTQKEAANDHFKAGRFQDAVEAYTECLSIDPSNKSYNAKLHCNRAAALAKLNKNEEAIRDCDKAIYYDSSYVKAYLRKAQCLKDIGGKDNLEQALREYETASKLVGEDQQRQYAQYIRETKLLLKKAKRKDYYKILEIPQTATDADIKKAYRKSALKYHPDRHANKTDEEKKQAEIDFKDVGEAYAVLSDPQKKQRYDSGVDLEDLDNDMAGPGGMGGMNPNDIFQMFFQGQNGMGGMGGFGGGGGFGGGGFGGGGFGGGGGFGRGGHSHGGSGTSFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XBB8</accession>
    <name>A0A6G0XBB8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_006599</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XBB8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015761"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033562">
        <property type="entry name" value="PLPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12406">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2 IPLA2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12406:SF42">
        <property type="entry name" value="PNPLA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="362"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="3">
        <location>
            <begin position="23"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0737437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="412" mass="46496" checksum="AC0E2B591483C670" modified="2020-08-12" version="1">MEPVTRKSLPTSYSFACSGWLKSYLFGVGKALQELELHHDATMLGTSGGSLAALSMVLDNDFDAMVNGVVNELVPAARSSFANAFRVREYLRDAMQRWGNFEVPGALERAKRCVVVYSSISKWASRRVSEFANVEELTQSVLASCCATPICGLPFRLKGEWVMDGGLFDFQPVLDENTITISPFYCTQADIKPSQYVPMWWAIYPPEPDRVAWLYQLGKNDAYMWALKQGYTTKTHIPPSPLDESSYQTKLGRFLGYKTMESRILDFFFVLTVAMIWKPVAFFLLYTELLIRAVVHATESGVLAVSSAGLWNWLAIMSVAFGFMVASAILPVGVLQWLGVAMCLLLCCFSECASRLEQSYHKWVRCLTCMQIMFSMSLFLRTIPLVGPSVPMKKHRWLIEHSIVYRLTKDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XBE6</accession>
    <name>A0A6G0XBE6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_006604</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XBE6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015756"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00473">
        <property type="entry name" value="PAN_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026005121" description="Apple domain-containing protein" evidence="1">
        <location>
            <begin position="28"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="2">
        <location>
            <begin position="63"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0737442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="763" mass="84122" checksum="05B0C1E8CBFF1EEB" modified="2020-08-12" version="1">MDIRLCDRSRMLPLCIGLSVLVSIAGSSVQNHVVQSIIHGFESHQACFVKESTSISAHRRLSSSSELSLFRSLSGFGLRGHNNEIIKNSSPEQCASLCVVDLRCLSFDVEANTCYLAFTDRYASPNDFLPRPASTYYEWQGAAASPTFEPNGGSFLTSTSVRLFTQTRAASVYYKVVASNGTLVSDFAFLAPNTSVTLPEFPCQIVALANKTGLDQSAVATSLVYNIYASKYMYLVPFYDGKSFHGKLTRIKLDVQGKKRPRPSLVLEFTDVDTFFGIGPFVDQVQVINLTTIDPRLCGFYDAFSVVATTNYVNVSLAASGDTSKWSLVEKTLYQPNQGDVVYNNQTLVTEEHMYLSPFMNNQGYSGLIAKVYLRAFDSLSSVSYVPAAVATLDLSTIDPDLTGFASCFTNNNYGYFVQRVNKNGLGGKIVRIDLAKFHLGAAAVTVLDLELKDPRLVGFGGGFTYGKYAYLVPLDRNKEGLELNPNYRYFPTPSSSLMARIDLTDFSTVNVLDLSILSPKYAHGFFGGFTVNSFAYFVPYMWTADAVSPSVNPYHGQVVRLNLLTLAVETLDLTLVDPSLKGFMRGFAYGKYAILVPHRNGQNNVTPRRLNPSQKFHFGKIVRIDTDVFTPDAVDVLDLTTALRAQIPNMPDVDLRGFVGGGATGEYGFFVPYFNGVRFSGASPTSIHKLTKDWSVGKVVRVNLRTFNEVQVLDMTQLDDSMRGFTGGILSKLQQPTDTSLWRYTIPQGTRAKYTFITAEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XCB9</accession>
    <name>A0A6G0XCB9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MATE efflux family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_006268</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000081">
        <property type="protein sequence ID" value="KAF0737774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XCB9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012554"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="390"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0737774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="458" mass="50072" checksum="332F178ABEA9A11B" modified="2020-08-12" version="1">MQPWLARWLYGPKGTEKARSLAFKMELFALIKISAPTFLTALSACAISLVDHIVAGHLGTSELTAVAYSRMLLDLIIIVFSQGFCEGTNALCSQAFGAKNYKSLGRYFQLGSFCLILASFPIGALSWNAGYILYRVGIPSHTAHLADLYRRYCIIGLMSRLLLKNMQSYFQAQHIVVPAAVISILFVGIDILIKITLTFGWTDDWRGLGFIGIPLATSATYWLLLLTYTIYMFAIQQYHKASWCWDCGQVFENAQLQVCAVVVAMTGQAQLAAHNSMLELFLFVTSPIYGLMTGSTTRIAMHLGGGQPLLAQAVSHLTLACIMTIAVCTSLALIFTQSFLGRVFSKDPQVVYYAVLNAQSRTLPVIIGFFVGAWLVGVPVAYFADIRWGWGLIGVWMGISLGYLITMAFGAWAVLKSDWENEAKKAVALFKKDDVQESSAATDGSATDGAIVNSVTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XCX3</accession>
    <name>A0A6G0XCX3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Crinkler effector protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_005980</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Host cell</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0737984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XCX3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007277"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043657">
        <property type="term" value="C:host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045379">
        <property type="entry name" value="Crinkler_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20147">
        <property type="entry name" value="Crinkler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Crinkler effector protein N-terminal" evidence="4">
        <location>
            <begin position="3"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0737984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="443" mass="49779" checksum="1AE7E0F0A1825061" modified="2020-08-12" version="1">MPNLFCVVVGEASPFPVDVAETETVGDLKDKIKGKKSNTIQCDADKLQLYLALKDGEGLRSSDAERVKLGDLEGFTKMDPLLRIKNKKHFGENFQPNEGEIYVLVVVPDESQAKRKLHNDVEGSHEQIKRKKYQHSKVGTTVGPKILRELKIDVVPVTTKPFATNNSTPIDPFLWESVKIDSGQQILLTEEQQRQNYLSYVRCHIGRVLTDKGLCVIGVEKKKSILNVEIPHHDIDLVGCTDLLVLGQVVQEDSSNLQYLPDVKLLIEVKRSIEDSSDFQALSELIALDLIVTNDPVMALLTDLNNTWRFFWVADMINGTKIIHKMTITEPGKAFYLIRKLLRQSSDQDIGLPFCEIPLKRRKLAVMFDEEGGNSGGICESIEQFNTISNSQQVNDSTDCPLDSFDFIACVAGLRYTTPMHHIDLPAFLPAINHLHQKMQLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XDS6</accession>
    <name>A0A6G0XDS6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_005834</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000077">
        <property type="protein sequence ID" value="KAF0738275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XDS6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018911"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000146">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1470.10">
        <property type="entry name" value="Photosystem I PsaD, reaction center subunit II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KLP-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972:SF28">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KLP-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="6">
        <location>
            <begin position="141"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Kinesin motor" evidence="7">
        <location>
            <begin position="664"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="234"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1000"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="290"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="14"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1000"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="748"/>
            <end position="755"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0738275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1058" mass="118895" checksum="C8017BBDDC883985" modified="2020-08-12" version="1">MERTPRAEGYNGSFAPSSPLQRSHSMSPTHHTHLPNASLSPMGSLTARRDADQKRAKDAGISLLGLAFGNGGPVSAPTQAVTSPVYYGHPETAVYDVIAPPLEGVDPNLFMEGVKEHAKYLGMNPQRDAEFLWIARESLVAPVPSGWHQVVTKEGAPYYYNDHTGESRWEHPCDRVYMDLFQQVKRMKEAGEHIDVHRLKQELQQRQTLGAWVQEDSYEISTDDGYSITPAWTEETSSTAYPDSDNGASYGDAGRTTNADYSDVHSGLQEETPKSEHYASIPQDQHRELVESLYSELNECKRKLELQREHQDVVESLQRKVLDFQTKLEAQADETRNREKTSKELQDVAQKAKEDKEASMTKIEDMENMLKQLRQQLDFANGELELSKSRSAQENVTLRQEVKTLELRLKDMEQSNSVQEIEKQLTKERKLKFQWEQKYKLLEEQHQALMIQVDNSNRKYEMDRHASQGDVEKYQKELELHRSKVEIELKESNEKHLQEIESLQQTLKTQYTEEIDSITAKHKEVENSLKEAAQQRENELISQLRAVEAELLTQTAALTDAKAQLQTLRKEATQTQSRYQQLETKDAEHQKLISLLQNELRDLRSGFQVELEKAKQLGIDEANASSQAKVQAAIAEKDQLAQLYAQELKARRQLHNKVMEMAGNIRVFCRVRPVSAIELKSDEAAEVVTFRPNDAQVLDLTMGEGQKHTFEFDYVFQPSSAQIDVFEQTKSLVVSAMDGFNVCIFAYGQTGSGKTHTMEGPATDRGVNFRAMEELFRVRDERMLSGNFECDMKLSILEVYNETIVDLLDDSQPSSSGERKGLEVRMGKQGAFVENLMEVEVFSTSDVEDLMKLGHSHRSVGSHDVNEHSSRSHLVLSITIMTVQKLDGKKAVSKLHLIDLAGSERISKTAASGQRLKEAQHINRSLSALGDVIASLGGHSKHVPYRNSKLTFLLQESLSGNSKVLMFVNVSPVQWNAWESLCSLNFAQRCRNVALGQAKSSHATPPASSAPPLSSSGGPSSASKQSKSPANKPTNTLTATEKVRVSLAPPKSPPRKDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XDV8</accession>
    <name>A0A6G0XDV8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="1">PPIase</shortName>
            <ecNumber evidence="1">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_005808</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="1"/>
    <dbReference type="EMBL" id="VJMJ01000076">
        <property type="protein sequence ID" value="KAF0738372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XDV8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009286"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00317">
        <property type="entry name" value="cyclophilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="2">
        <location>
            <begin position="146"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0738372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="278" mass="30872" checksum="6329F62EB351B6C6" modified="2020-08-12" version="1">MSGNVVVEVAGILTDPNFQRMRSMALQLREQVSSVTVIFHSMVEADYVPFLDKRGLLLQFPHHNTSAPIAFMPVADSNNDGDGDTYIGDTDAFLDLCAQKYQLEDTLTGRDAIVKATEAWEEYRSRSRNVFCFFKFASDDQQFNDRVVIELFQDVCPLACENFATLCRSDTKNGYNGLPVHRIVPGGWIQSGDVECGGRGDGERGGIVHEDGLFEDEAFSISHDKPGIVSMANNGPHSNGAQFFITLAPLPWLDKFKGTTHLLVNSRKHNHSGIWTSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XE98</accession>
    <name>A0A6G0XE98_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable pectate lyase F</fullName>
            <ecNumber evidence="5">4.2.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_005734</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Pectinolytic enzyme consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins. Favors pectate, the anion, over pectin, the methyl ester.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Eliminative cleavage of (1-&gt;4)-alpha-D-galacturonan to give oligosaccharides with 4-deoxy-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.</text>
            <dbReference type="EC" id="4.2.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the polysaccharide lyase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.2" evidence="5"/>
    <dbReference type="EMBL" id="VJMJ01000074">
        <property type="protein sequence ID" value="KAF0738505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XE98"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007425"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004898">
        <property type="entry name" value="Pectate_lyase_PlyH/PlyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33407">
        <property type="entry name" value="PECTATE LYASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33407:SF9">
        <property type="entry name" value="PECTATE LYASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03211">
        <property type="entry name" value="Pectate_lyase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026280308" description="Probable pectate lyase F" evidence="12">
        <location>
            <begin position="23"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0738505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="351" mass="37303" checksum="950812A325B2922A" modified="2020-08-12" version="1">MVQIASFALLAAAASLLDLTSAVAPLPTGTWPTSQGNVKYSSPYVVKKGEVFDGKMKTYERSNVACTGDTEGGKDTAVFWVETGGTLKNVIIGKNQAEGVHCEDHGCTIENVWWDDVCEDALSIKGGSASSVSKIIGDGARSADDKIIQHNDFGKLYRSCGSCKTQYQRKVTLTNVYAVNPEVTLVGVNKNYNDQAKFSNIKIKSSKTPNVCTYFQGGTSGEPKELGSGILSPTCQYAASDIHSSEHIHSKESRAGQAEGGKDTADFLVEPGATLKNVIIGKKQAEEIHCESHDCTIQNVWWDDVCEDALSIKGGSASNVAKVIGGGARNAEDKIIQHNGAGTVSIEGFNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XEX9</accession>
    <name>A0A6G0XEX9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Argininosuccinate synthase</fullName>
            <ecNumber evidence="3">6.3.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Citrulline--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_005424</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.5" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000070">
        <property type="protein sequence ID" value="KAF0738813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XEX9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006800"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004055">
        <property type="term" value="F:argininosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000053">
        <property type="term" value="P:argininosuccinate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000050">
        <property type="term" value="P:urea cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01999">
        <property type="entry name" value="ASS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000019">
        <property type="entry name" value="Argininosuccinate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1260.10:FF:000003">
        <property type="entry name" value="Argininosuccinate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1260.10">
        <property type="entry name" value="Argininosuccinate synthetase, chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.470">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00005">
        <property type="entry name" value="Arg_succ_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048268">
        <property type="entry name" value="Arginosuc_syn_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048267">
        <property type="entry name" value="Arginosuc_syn_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018223">
        <property type="entry name" value="Arginosuc_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023434">
        <property type="entry name" value="Arginosuc_synth_type_1_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024074">
        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00032">
        <property type="entry name" value="argG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001770">
        <property type="entry name" value="PRK00509.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587">
        <property type="entry name" value="ARGININOSUCCINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587:SF2">
        <property type="entry name" value="ARGININOSUCCINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20979">
        <property type="entry name" value="Arginosuc_syn_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00764">
        <property type="entry name" value="Arginosuc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69864">
        <property type="entry name" value="Argininosuccinate synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00564">
        <property type="entry name" value="ARGININOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00565">
        <property type="entry name" value="ARGININOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arginosuccinate synthase-like N-terminal" evidence="11">
        <location>
            <begin position="10"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Arginosuccinate synthase C-terminal" evidence="12">
        <location>
            <begin position="184"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0738813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="420" mass="46886" checksum="0B92AED9403A3DDF" modified="2020-08-12" version="1">MSVKANPGDKVVLAYSGGLDTSIILKWLVNKGFHVICYCANVGQFGENFDKVKAKAISLGATTVYIEDLRKEFVVDYIWPAVQANAIYESRYLLGTSLARPVIAKKMVEIANIEHAQYVAHGATGKGNDQVRFELCAQALNANLKTIAPWRDPEFIEKFKGRQDLIAYAQEQNIPIDATPKAPYSVDENLYHTSYESGMLEDPMTAPIPEMFKMTVDPKKAPNESEQIRVHFQSGIPVKVSNLTTPGQEHTDPLLLFLELNRVAGKHGIGRIDMVENRFVGIKSRGVYETPGGTLLREAHLDLEGLCMDREVMKLRDSLSVKFAEFCYNGFWFAPEMDFVRNAISYSQKNITGHVDLELYKGNVTVIGRYSDVALYSADLASMDQEGGGKNIEYNPSDAQGFIRINATRLKAYHLVQKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XF05</accession>
    <name>A0A6G0XF05_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CLASP N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_005381</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000070">
        <property type="protein sequence ID" value="KAF0738767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XF05"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013901"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024395">
        <property type="entry name" value="CLASP_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12348">
        <property type="entry name" value="CLASP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CLASP N-terminal" evidence="2">
        <location>
            <begin position="53"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0738767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="300" mass="33046" checksum="AC5D45FCFA96CC99" modified="2020-08-12" version="1">MNTLFCKIDACRATLEGYSAQCTMTGALKKLRSCLKRAKLESKNAVVEHMLPLAASVRAKLLSSLDATVVQATCGVVASFARQLGAAFAPFADVLLESLLDAACVRRMSAEDPAAISMASTYCAEALAETTLLSVQTLHGYYKAARATRNHRTEGGWKRHLVVKLLGITVETCTKEELEPGYSLLKDFVREALHDNFLLVRVEARQVFSSLYDTWPERVHEFVYMPAPRIRAVLMVDVYATTGIGLALQHKFPSKACPRPAAVKSDPPKNLNQRIDFEVQEQPEEKDGRSSSPRMASGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XLQ9</accession>
    <name>A0A6G0XLQ9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_003718</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000041">
        <property type="protein sequence ID" value="KAF0741155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XLQ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009621"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="5">
        <location>
            <begin position="124"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="126"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0741155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="221" mass="25217" checksum="ABC101B86D5E82D0" modified="2020-08-12" version="1">MTSMNQAKQYEESTADAILSPVVVAEDVAAAARHLQTDTTWKAIAHVFSYPPGDQNDAIPSPYASPSSVKAGYMAEAFAMLEHAKDPNVLQSRYRQAIDNLFASQQQQQQMRNWNGGRATATWSKKAKKRTNLSTDAKRVLREWFDAHFHHPYPSEEEKERLRHDGGITLDQVNNWFINTRVREWKPKLHQILADSDKGDSSQLDEMLDKVKAPYQTQEFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XMC2</accession>
    <name>A0A6G0XMC2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Chloride conductance regulatory protein ICln</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_003461</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000037">
        <property type="protein sequence ID" value="KAF0741350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XMC2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016720"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034715">
        <property type="term" value="C:pICln-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039924">
        <property type="entry name" value="ICln/Lot5/Saf5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21399">
        <property type="entry name" value="CHLORIDE CONDUCTANCE REGULATORY PROTEIN ICLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21399:SF0">
        <property type="entry name" value="METHYLOSOME SUBUNIT PICLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03517">
        <property type="entry name" value="Voldacs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0741350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="199" mass="21897" checksum="9DAD53D5D85D48EE" modified="2020-08-12" version="1">MNALHLADCASNGAPVLIDDEEILASFTNVRMFTNTYGPGEDDSPVMDAKGSGNLYVTTSRVVWVFSQNGSGVVGYAWDMTYLSLHAISRDLSSFPEPCLYCQLDVEDEVNEIRFVPQDPEKQLQALFDAFSESAALNPDDDEDDEQQGGDWIYNEEEVSTGAREAALAAHFDSILQVAPSLQQHADGQFDDADEDEML</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XMR2</accession>
    <name>A0A6G0XMR2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">oligopeptidase A</fullName>
            <ecNumber evidence="8">3.4.24.70</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_003123</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Hydrolysis of oligopeptides, with broad specificity. Gly or Ala commonly occur as P1 or P1' residues, but more distant residues are also important, as is shown by the fact that Z-Gly-Pro-Gly-|-Gly-Pro-Ala is cleaved, but not Z-(Gly)(5).</text>
            <dbReference type="EC" id="3.4.24.70"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the peptidase M3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.70" evidence="8"/>
    <dbReference type="EMBL" id="VJMJ01000035">
        <property type="protein sequence ID" value="KAF0741753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XMR2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000920"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06456">
        <property type="entry name" value="M3A_DCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034005">
        <property type="entry name" value="M3A_DCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045666">
        <property type="entry name" value="OpdA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF83">
        <property type="entry name" value="LD37516P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19310">
        <property type="entry name" value="TOP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Oligopeptidase A N-terminal" evidence="11">
        <location>
            <begin position="30"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="10">
        <location>
            <begin position="236"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF19310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0741753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="699" mass="80071" checksum="2981BCC25FDC2417" modified="2020-08-12" version="1">MVNPLTRCAEDYALPPFAQLRVSDIVPAIRAAIQEYALDLNAIEDDLSFFQDDITWESVMDRLEIIDDPLNRLWRIVLHLSGVANSAELREAKAEVQAEVLAIQSRRQQSVEIFEAMQTLRDGPWWAELTSEQQRILDRSILEMKLNGVALTGAEKERFNAIDVRLKELGDVFSNNLLDATKTSLVLHDRSQLEGIDDSSLALFARDAVAAGYEGATAANGPWKILLDGKNTVPLLNNCSNTSTREAVYRANRTRASREPHDNTCVIHEMLQLRRERANLLGYATFAEMSLADKMAPSVEVVQEMLRELRDKCFEVSAVELRELKAYAEAHGQVEPLQTWDIRYWINKMRNDKYALDNDLISAYFPLPSVLPRVFDFLSKLFGIRIETADESEETWHPDVLYYQIRALEQPGEPVIAQFYLDLYARPGEKKALSWIEVVAPRSRVLRTEKANIRTPVFALMFNQPAPVDGKPYLMPWFDVENLLFVLGYGLRIGLTAAEYTATSRPHGIEWDAVGFSAQFMHNFCYHRETLKSVSCHVETGEPLPDEIFDRIYKSRTFMQATNFAEKYLEVASYDMALHHEFDPQGDSDTMFDVFRRRRHEFTLQPPFHDDKFICALEHIFPSLYAASYYSYVWSEMLAADSYACFHEAANEEEWMALGRKYRDTILALTGPAHPMEAFEKFLGRLPCTEGLLKQYGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XMT2</accession>
    <name>A0A6G0XMT2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_003363</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000036">
        <property type="protein sequence ID" value="KAF0741695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XMT2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001398"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF73">
        <property type="entry name" value="PROTEIN PDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="3">
        <location>
            <begin position="67"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="138"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0741695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="508" mass="58109" checksum="F49E0483CD91B9E1" modified="2020-08-12" version="1">MKKRQALSLADKKRICEISQRLEKATHQQIADEFNKTAQRNVQRLLVTKTLREKEKWLAMEETQQLNRKRMRTGKFEALENALSLCLQNMRTQGDRLSDHVLTAHAERLRTEYHIKESEFKISNGWVQNFKRRHSIRMHHHQDGHTDSDHGTKPGDLSFLKQLDPPTTDKELEQADTHHVGSNIGVHQLIVDGGFKPANVFHYDEHVLYFRPEEQSSQRQRRILLGLMANAVGDTPLLACIHAGKVSSDISNLADILYTSEFVDTHPQVRMTKEIFAKFVVHVNTLMAMQERRILCFLDPSPWHLISMDGHMSTICGLQTIELSHILLAFLPPKVPPHLTPLGAGITQFFHLQYKITFLKWMLSLMEVPNGGTSNTAAMVFDDQAMLWCCQLWKACPASLIKTSWHQSGWLPPEYLEDDEETTTPMAESLMTQAQEEWKTLHLMFHGDDTEQPLAWTEPAASPAVEAAQRVMQFIQLHQTEFTSDDITAMLNIANRISTIEMAAPTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XP06</accession>
    <name>A0A6G0XP06_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Heat shock factor binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_002896</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HSBP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000030">
        <property type="protein sequence ID" value="KAF0742232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XP06"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016361"/>
    <dbReference type="OrthoDB" id="4159489at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070370">
        <property type="term" value="P:cellular heat acclimation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.430:FF:000003">
        <property type="entry name" value="Heat shock factor binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009643">
        <property type="entry name" value="HS1-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19424">
        <property type="entry name" value="HEAT SHOCK FACTOR BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19424:SF0">
        <property type="entry name" value="HEAT SHOCK FACTOR BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06825">
        <property type="entry name" value="HSBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0742232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="92" mass="9788" checksum="351C95DCADAA041A" modified="2020-08-12" version="1">MNKSSDDVSTNATGQQDSQELTIFVQSLLEQMQSRFAQMSEAIIGRIDEMGSRIDDLEKSIGELMEQTTANEAQKPAAPGSAGAAPASAPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XPX9</accession>
    <name>A0A6G0XPX9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/hydrogen exchanger</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_002722</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000029">
        <property type="protein sequence ID" value="KAF0742320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XPX9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014112"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098719">
        <property type="term" value="P:sodium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004709">
        <property type="entry name" value="NaH_exchanger"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00840">
        <property type="entry name" value="b_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF187">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0915">Sodium</keyword>
    <keyword evidence="8 9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="147"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="12">
        <location>
            <begin position="2"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="387"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="396"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0742320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="418" mass="46538" checksum="9E57C24FC54BC5AC" modified="2020-08-12" version="1">MLYAVVGTMISTFMVGFLTFYAGKMEWIAIDSSSPLEALLFGALISAVDPVATLSILGNPELNLDPLLYSLVFGESVLNDAVSIVLFNTFLKFEESGKEFTYGAIWMLMFEFIMISLGSVVVGFVTGLGCSLLCKNTNLKKYPKYEITMLFLFAYGSYSLAEVMKLSGIMSLFFCGITMAHYNTTNLSSTSQITAESIFQSFALTAEFFVFLYMGMGICVGQFGRWDFKFMVLAIIFCLVSRLFNIYPLSWLANWKRKEKVSMQMQTVLWFAGLRGAMAFALSQDMPGANRDLYTTTTLSVVIFTTIVCGGLTEPLLKKTKLKIDEDELDEFDEEYGLISTQEVSDHQLSPESPGVASIRRMSVESEPSYVESFWGNVDDTYMKPIFGGISRRPSSHTVSTASLSPPLQEETSSPHEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XQY6</accession>
    <name>A0A6G0XQY6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_002430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000025">
        <property type="protein sequence ID" value="KAF0742730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XQY6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002272"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0742730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="202" mass="22215" checksum="AC17BB1E44C9A95F" modified="2020-08-12" version="1">MAEECALKLSSIKFSRLADGFRLHVDTVAKDVPMKIWMENQRSKDEWECAVEDIAEHAPRGAKYMLPSSVVVASLMSALRAKSTDGGGGSKERKVELTAGSDESLNLVLTMTGFERLAVEYTFSLTRLNVDATQVLEAQIRDLLEDVAQLKAANALASAQSSPLAEVRAELRSPTSQEISICSPKCLFYKRGRSCILHSRHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XQZ9</accession>
    <name>A0A6G0XQZ9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tyrosine specific protein phosphatases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_002038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000022">
        <property type="protein sequence ID" value="KAF0742973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XQZ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003044"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14566">
        <property type="entry name" value="PTPlike_phytase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01301">
        <property type="entry name" value="PTPlike_phytase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0742973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="447" mass="50357" checksum="8F8395FC22A32929" modified="2020-08-12" version="1">MVKVEGDASRENVDSDSQFQEQGTRVLEKYLLKKDRVPGLHKLDTPNGDIAPNFRRLNGSPIYGCAQPALEGIRYILNTLASDGFTKVVWVNIREEAVIFVEGIPFTARPSSKLNENDMVPDITGNSIAVLEASLKDSLLEQLSRSESKLEYWHEPTLLCNELVTQLVDPKQVKTLHEVMADIQHPGIESVIFQRATIERGNFPEHQIVDQLIEWISKADLNTAVVFNCQKGRCRTTTVMTLAYLIWSAPLQLSMSVSEQPFAKLMQAASMDSQTMDYKLGRYKVILALCDKLANGVRSKEWIDQAIDKNALIYHIRHVIGDNRKKSLEEPQPADRAFYLHRACRVLERYFYFIVFGSYLLEAPSAGNTFTSWMLEHPDLCGVFDSLGGAANTSSEVFEELLSLTGKSKEIDQFHISVFKAVNGSKDGSETLTARLILYHKVDKKVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XRA6</accession>
    <name>A0A6G0XRA6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_002141</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000022">
        <property type="protein sequence ID" value="KAF0743083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XRA6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009994"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="530"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="200"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="270"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="432"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="536"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="557"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0743083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="570" mass="68611" checksum="093FDC21AB8FBDF7" modified="2020-08-12" version="1">MWQKWQARLSYCRIKFCCDRKTERFVAKKYVAVWYNFSDARKRRTRALQIATRRWLTQTMRKVWALWNQYKSMRRKYIQGCIKAFKHYRAKLERRVWRAWAIATTAHLQYRNQQKHGKLQYAFSWFVQAVRKQKNRNQLERRTVHLQARRSIWWLSHCWNKWRMYSIKRKKPRGLMHFIRCQRLQLVQFKYWTVWREVSRKNVAKRIHDLESNLSQSQTERESILAKVLQLNDTSIELAEEVSEWKSVAMQKEETIKSWQQSCQKTEHANMVLQQQISTLQHRLQDFEQQGRDREHIMEEERNEWRKQINTLEEQNDCLGRKLQDTQDDVLLHQQQLAREKDKIVRQDNEKKKLQHVIDQKQIDYAKLEQTLQNVERALSVERAERQEAALRCKDYEKRLADTVRAIHEHEMDQEAQLRQTHGLAVDMERRWKEQEAKNAELLKLLQEKNNQVAAMTSEIQTYRSVESHRMNNLLEEVQANIIQQKSNFVPQVTPLELEGEMQVLNAHTASIHDDIKSLQQRIKLRLQQKPLGEQRVSTPISKETPQAYMTSIIGSKSKKAKPKAKPKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XRJ9</accession>
    <name>A0A6G0XRJ9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_002135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000022">
        <property type="protein sequence ID" value="KAF0743077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009999"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF63">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="423"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="807"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1185"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1279"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1339"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="537"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="423"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="817"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1210"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1236"/>
            <end position="1248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0743077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1385" mass="158191" checksum="8C26B6EEE288F8A9" modified="2020-08-12" version="1">MLDIETEDDVALWPESDMPIEQLDRLQTPQVIPETEDFPWTQEVSSSNNRPPPGMPDPTLPQIPVPIPPETPLNSKRELSSIDKRKLIKIPPAEQEITRMRRESYVMFMKRKREQNVQPPPTRNALRDFPLIEVPLFVPPERMEEEVVISGDSAAVEEWVNAHLIKGHTQLIPISDAYLAAGGKKTQTSMYQSKLEYSDSSQVNVISPAEKTPLQGAGIDSTSLLQLGMPKALVERIYRGLFVYSSGFHTLIHDIGRHCPAYAECHIASNVWLAFLHLLEKCEDGRYEMAMLKFNHATSIWKKSKMKEYEKEKEALLQELTKTQDDVKTEKENVATALGKLADQAEAMKQLDEKMRTTQDKFDEFEDEIRLLKMEIMKLEDDLVKKTDEHVQTSHALSLALTQKSDIESEISNFKAQIAAATKKLDKHEENKNRSSGRIRELQSNSQALREQAEVMRNEIRLLTMDKTKISNERTTFAEKSAALEKELASLKTQLANLNNTSKSQRRDIEERDATILSLTEAMEKDRNQFVSQQAEIARLTTLVNRQKMDYEVLEAQNQLLLIEKNNISQKEADKARIERLLNKKVELEQEIALLRQEKEQGQEQIWNLRASMEALENDLHHSKRAYAGSQTSLAQAERICEHLRGQMQEMERANEKLTQNLAIQKQQSKLLDDASREQVEKMEIELRVVMGQMREMVYTRRENEAQISDLTKSLEASAVEIRLNKLRIEKGDKDLAAMTFERDTLLRDKRIAQLDQSTNKAMIQHLNHATAQLMEKIRLHEINYEEAMLELKVHCDNATKVSTSLSSTASGIDLHSPQQPSRQSSSSSPQSSTSNLPPSVSGLLNLLVLQGAMENGGNGGHSGTLGALDIRMNRRPRRRSFKGGAIPSQNEYTIVELTAKLKKRDETIRRMDATIEEGRLALHQKQLAILREKERCAEWKENVAMARADHDTYKWIATTRYTALSLKCAEVESSLRDYKGKVKTLRGCLRNYKTLLDHMGMHAEDSRGTLMILYRKFITRRDQEVQATEPISDNSTQTYPPRRSPIKERAKLKQSMFSTESTAFGVLTTITDLLPDEELDHHFYSITHHGEQHTREYKLGHLLESKREARFKPLPQLARDSERQAKVPEARILAEYRNEFGHIERIAEPAIAPFHFDRPRTKDDKFRVSAKLAKELEARERLVHEINDGDYGKTSVGRPPARPSPRPTGHSKRTAGHRKVLDRPAESPSSPQQQKARRNPLARKKPRKIQDQGIIAQNEMEAEVLRLEELKAIEHATQYTPSVGAPPDYKSDENDEDDDEAQLDAYFVEEDGVLKRRELGGGRFPSLLEQKVKEMHEMEKLRESTSPTKRLVGWELSGKQVQSDRGETSESTTLPPILYPLTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XRS9</accession>
    <name>A0A6G0XRS9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_002110</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000022">
        <property type="protein sequence ID" value="KAF0743051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XRS9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015653"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050367">
        <property type="entry name" value="APC_superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42770">
        <property type="entry name" value="AMINO ACID TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42770:SF7">
        <property type="entry name" value="MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="432"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="456"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="7">
        <location>
            <begin position="77"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="528"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="528"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0743051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="573" mass="63586" checksum="1EE9F2122C24C855" modified="2020-08-12" version="1">MSLIWSSSESSVFPLPHILKSTMPATVQPIRLKSQLPDKDLKAINWPKVASTSFNLWAAGITIVIGGQYFSWNGGLTAGTLSYGIAAVMMGFAYICMGLCEAEMASMFPFEGGAFGLARCTWGFYAGFIVGCCEALQYIIYVACAFVSFGKMLGSFWPFAESQPYIIWFLAYALSSFTLILGGKIYWRWNVALALYSIGIIIIYVFGSMPYVDIKKFGGGQEYLVVGGFSQFMKVFPMSAWFYVGVESINRLCSDAYEPRLSVPIAQISCILTLFCSAVMVYFVAISMHPGMPEISKALSPLNYGFERMFNCSDDVSVWFSIPATFATGQGFVQSYSKILTCMAGSGLLPAKMHEKHSSLNTPIYAIVLGSIVSYCLCFLDYFYSLDAIFFNTCMVMGSISYTSQCVGYLYLKKNFRTMERKFQSPLGKAGAMCSIFVWVLLAVAVVGFQDDHQDSFIALVAILLICTVYYQFYAKSRQKFSEEERMSLFFAHVANHNKAKRSMNSRKRHHSGGFFNLVKRVAMSKVSTSMGPSNSNPQIARASSAGKMKRSSGISKDPSLIEVQSPPMRRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XRV4</accession>
    <name>A0A6G0XRV4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_001925</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000018">
        <property type="protein sequence ID" value="KAF0743299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XRV4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007959"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
        <property type="entry name" value="FYVE_like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019494">
        <property type="entry name" value="FIST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013702">
        <property type="entry name" value="FIST_domain_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08495">
        <property type="entry name" value="FIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10442">
        <property type="entry name" value="FIST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FIST" evidence="2">
        <location>
            <begin position="356"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="FIST C-domain" evidence="3">
        <location>
            <begin position="544"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0743299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="677" mass="73684" checksum="DA2BFF3D8F32D3EC" modified="2020-08-12" version="1">MAMSVRASSVSAQSITERREQMALSQRQRLREKQTYARTRARTCMQLLQDDKSSWQPQGAKGGIELFKSKSAMWKDVRTARAVTAIASTMPRVVKALLDSASSSARFQHFWQSVFSTTFVHAEVIEDLCVSPISDQRATAKWYALRPSKLRRPNDYFVIEWIGITRDEASNITACYLFQESIADVGALEKATNLPAISFERDHLASLLVKFEPTPDAIRISLVVQKPQGLLEFPFGASPAVDFAFQFAKGLRGALETPGQPPARPRACHHCAKAFHAFNRGRTSCASCHHIICQRAACAVTCPIPTLPELPSPVAESPRPFRCASAWSIHMDLNAAVRAAWQEITDKLDASTNISLLIVHYSPHVNAELVQAVLHQVAPNVPYIGGSIGRGLCDNEAWVAPSKRIVALFGIYDPEGSYSIGHAAYDSAATSLCHVTALRHNRPTPDVCLVFATPLFMDAAMAALQGLFVVGGGATDAKGHAWNQISSTRNEPTINGLVAAFCSPSVIIERCWFSGYSFIDEEVKTVTQVDETLTKVVTIDNEAAASVYAGWLGSTRWSSFPRVGNLHPLALFDDTNDDEYVTRVVVGADDGVLELSNSVSVGVQVRVMELSKESMTTAMGKWGDQIKAMPGVQGSLMYMSASMNVLLGSPSMAEMVTAFNVASKGASFLGLSTTSFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XSZ1</accession>
    <name>A0A6G0XSZ1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL15/eL18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_001401</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XSZ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013074"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.100.10.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L27a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_uL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_uL15_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="6">
        <location>
            <begin position="72"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0743747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="148" mass="16393" checksum="8FCCFC72096B1726" modified="2020-08-12" version="1">MPTATHKNRKKRGHVSAGHGRIGKHRKHPGGRGNAGGQHHHRILFDKFHPGYFGKVGMRQFHLLRNRYHCPTVNVEKLWSLVSEEVKDAAEKAKDGKAPIIDVTKSGYFKVLGKGRLPSIPVIVKAKYFSQEAENKIKAVGGACLLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XTN8</accession>
    <name>A0A6G0XTN8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_001453</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XTN8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002692"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="27"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="174"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="8">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0743806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="365" mass="41204" checksum="E53E8B7F8285CEAD" modified="2020-08-12" version="1">MVRRTIDQQLRDVLGPQITEEELLEKITFERVIGNGATAKVYEALDRKSGERVAIKVFDKAQMIETRQSILGDEYVSRETAVARAQRRLKKIITELEITQALDHANVIRFLGGYETSHRICIVHELVDGHDLLDYVLTYQKMEEALAAHVFEQLLRAIQACHDLNIWHRDLKLENVLITREFHVKLIDFGLSERTLSRLSSVCGTPLYCSPELLFLPTNTREDGVWGGPADVWSGAILLFALLTGCAPYNDSSFVTLRQDIYKNEIAYPDHLSESVQDLLRSVLVSDPEARPTAADLLQHPWVVKNSTSYRSSVSSKSPRIIFRAASGNSETEDSSDNGSFDESNSYRDLLYDELVDQTSLVATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XUH5</accession>
    <name>A0A6G0XUH5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_000798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XUH5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012469"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF73">
        <property type="entry name" value="PROTEIN PDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="1">
        <location>
            <begin position="3"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0744310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="144" mass="16099" checksum="69E04E319953B7E2" modified="2020-08-12" version="1">MVEKNKSILLIMDNASSHKAIGVQLTNIRLLMLPANTTSFLQPLDAGIIASFKRGYKRRQMKHAVSLIDGITDGCKLTSKMFAVDVLVAMRWLTEAWEEVPRSTISNCWKHTGIVERGAVERRVPCAIGRFSLDFLLNPSRLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XUY8</accession>
    <name>A0A6G0XUY8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_000967</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XUY8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010434"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052050">
        <property type="entry name" value="SecEffector_AnkRepeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586:SF5">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0744491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="297" mass="33659" checksum="A6F9044CCE6EA653" modified="2020-08-12" version="1">MLKVLASRELLQLTCKFQDGLPLDVRPLKRAFIEAFEARQLFLYGTHAFAYFRCNSEFLQDLDHMLKTFDEWYAINGLSGLPRLVALLPDAEFLAMTYASCVGDVDLFQRICRSSHEMLTFQYLLALASWFQQLSMVKILTTYIPDDLVIRSTLAAVVLGGNAAIVEHLHNHGAQETNLMDTAAKYGHRDVLAFLHEHQVGRCTKAAMDHAADRGHQDIVEFLHHHREEGCSYRAIDMAAANGHDQIVRFLAEHRSEGWSSRAIELARFNGELEIARYLSGRKNPRETGTLPVTTIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XWR1</accession>
    <name>A0A6G0XWR1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dolichyldiphosphatase</fullName>
            <ecNumber evidence="6">3.6.1.43</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_000585</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a di-trans,poly-cis-dolichyl diphosphate + H2O = a di-trans,poly-cis-dolichyl phosphate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14385"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19506"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57497"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="EC" id="3.6.1.43"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the dolichyldiphosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.43" evidence="6"/>
    <dbReference type="EMBL" id="VJMJ01000003">
        <property type="protein sequence ID" value="KAF0745004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XWR1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014748"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047874">
        <property type="term" value="F:dolichyldiphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03382">
        <property type="entry name" value="PAP2_dolichyldiphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039667">
        <property type="entry name" value="Dolichyldiphosphatase_PAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247:SF1">
        <property type="entry name" value="DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE/DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="8">
        <location>
            <begin position="194"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0745004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="358" mass="39123" checksum="A6B23F5A8DE8ABD4" modified="2020-08-12" version="1">MGVFQPCDTCTEAPTTTPAPPPPTSAPNEEVDSVPLTENPPSMEQTIEEEIVPTQTDALPIHHNSAPLVLPDTNNAPAPEHKPFITEAVPPDDADLDEIPMSFPTTTAAVAAATALAENAANHVKKAIDDAASTALLTGVSEPTGVLKKPFSLTWVMYDAADPLGQLLALVTLSPVFIMVMYATLILFQRDLHIIFMVLGQLVNEVFNQILKRTIDQKRPDGADMEDAGMPSAHSQFMAFFATYVVLYTSNRMSKRREWEHKLAIGGVILLALLVFFSRIRLGYHSVAQVVVGAAVGAGTGILWYIVLENIAMPLFPTIASWDISKLLFIRDCSHIPDMVEFQYEAIQKKVKSKYHGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XXF6</accession>
    <name>A0A6G0XXF6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_000420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XXF6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001273"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0745401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="297" mass="32508" checksum="89165BFB4A373312" modified="2020-08-12" version="1">MAATANELDSEIEAYGYATDLIIVLSLSDGDKSTWNMQSEGMRRFVDGLTALAALECDDRGILIRRMLLAQGSSAVQNLVDALGCREVLLKCKSASALGSICMCPSAGATLMEQFGSTLLKRLLRMVQTKNRWAQGDACFVLGWIVRWANVDVVREIAPCVSKVCDALTSTFTSAPPTDTAFEPDQDRKSNLRIYPLILLLNLSQRVVLQDEGLVVGTLDVLFQGLLQDVEMDEGTTIAQLAVSLLVTLTHQSPEARQAALDRKLLPTLVRLSRRPFDIPDIADQLHVAMNVILSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XYE7</accession>
    <name>A0A6G0XYE7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_000003</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000001">
        <property type="protein sequence ID" value="KAF0745547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XYE7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003341"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07440">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF192">
        <property type="entry name" value="DOUBLE HIT, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="240"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="414"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="563"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0745547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="731" mass="82685" checksum="C70852E6A7859144" modified="2020-08-12" version="1">MGSVLGKLWARGSRPPVALNAVEPISAVPPSQTRTKIPATAAQDEQDALDKSSTDMMTPLPRAGKTARQILKSVISPSTKNLLAEDTSAEDLLTGSKTSQAFLSYIRNTEETNSKNGSVIENALVFWLTVRDLDFVPEGLFRSVIIAGAYETYIQPHAKREIPIVSNVERQQLKTFVDELQMEDATAILQQISLDALELIRSSFAAFLSDRGPLGFRETRLNKSTLPNFPKDTQGEQREMLEDLLEQPSSCRAFREYFMRIGGCPEFMFLVDVLDYKDTVSALHQESMSEQKQQLHVGYTMRKLRKIYNKYLKAGSRTMIQLEERQREAILLDISKHDIPDPDVFDSAMNSCAYVIILEHLQLFLQSPEYEASKSRRTEPEIHGEKDFFAPTNGLPTIPIPSLPTIAGSSAAKFFRAFLRTQGVESTLDFYLEIEQFKLLPHNKKGYIAAIAGKIFKKYICRGAKLEVYLPSHIRQNILQEIADPQDSTFNEAREYVLGLWERKYLGPFKSSPLCVEMHAHLVQEQKTLEESSSVRQVQAEAMSSSMFRDLLVAEASTHMVQFHKFLVKESCASYSLFYYEIEEFKRLPKSDYLSRQAKKIFYRFLDVTAKEPVSVSSATVADIQVHMRDPSPAMFRPAQDEVFQFLHKVLYPKFTKSPFFADFTMMDKAAEKQGGKDLRSTMSALRKSAVAPTPTLSTSEKLVQQGEITISTILANQDTRAMLLAFCEEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W216</accession>
    <name>A0A6G0W216_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_019256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000583">
        <property type="protein sequence ID" value="KAF0720939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W216"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017454"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0720939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="479" mass="54032" checksum="8E7C20C58BBA55CB" modified="2020-08-12" version="1" fragment="single">MILDLCGAVLAYMASYITTQDHANTTAQANDSDLDKPTHQDLTDVQTIKKESRLDSVNSINDDHHTACHSKNNSQEQGNTSNEDSTTPVHIVDVAQSTKEDNDFTEEDDDRCPFVCAWEVAHLPARYSTEDKYIFRKEYDHDAAAKHKEAMARASAYVDKILDDEGFVRIEDLHAMRTASVTQDGNHIDAKKKRHREDDDEDIDKSAKRVKFATTTVYSFPIELGECSIATFGPLGMGQRHVAQELFDLSTIAEGDRSHSKTEVPAFVAPPKYDKIPREERLARLRAAGVSDADIHAHAQVALDIARKKSIEKDQMHEMEWRRKLKKRLHRASSRRQRHVAFVAAAVYTFDIGLGGSAISSDGGLPLGMSSTHSQLEIFDLTQTIPTDQQRMEPVSPQERERRLDSADMNPARTTAYKDEAAAIDHSRYIDKVKRFKDNTLDLLARQSELDQRRSCGPYEPNHESGQEKKRRAPDDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W3R4</accession>
    <name>A0A6G0W3R4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_018936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000367">
        <property type="protein sequence ID" value="KAF0721758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W3R4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020443"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0721758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="91" mass="10152" checksum="3006843BA61CF0EA" modified="2020-08-12" version="1">MPHVVSNHALTPEEKEAWAKFLAQHNKSHVPTIAFKESKDTTSKLDALHAPRSFQINFVAVFGVLVVVLALIAIRRRRIQSARGYIPVPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W3R9</accession>
    <name>A0A6G0W3R9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_019014</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000375">
        <property type="protein sequence ID" value="KAF0721642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W3R9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021610"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0721642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="102" mass="10643" checksum="F7C782F2A078AE2A" modified="2020-08-12" version="1">MMSHEGTTTDLITTTAATLTTHTMAVVAAVEAAAVAGLNRVKTTAAAANTHPLVVATATHGHLNMGGEICHLKQPVAKMQFNTVVGSYQLFLKPEKQRGSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W455</accession>
    <name>A0A6G0W455_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_018905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000364">
        <property type="protein sequence ID" value="KAF0721798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W455"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016272"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="72"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="199"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0721798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="368" mass="43965" checksum="C012F4AF0E12263B" modified="2020-08-12" version="1">MAGLRGARTLTKSKAPRPEWNEDMTDLSLQQSSEKEMALKKLQRTSKHLEDAKTDLYFKATVEKLDQRQRDLNAKELKVQSDQEKLQALEATVMQKQLQMNKLYQHLERDLNENTTRARSLNQLEEELRRREAHAQPKILELDQLERSLLARDEELRLRETALAIKEQDLTLLGERLVIQEQHLGTIERLVDEREKESKSEQERLRVKMNQEIASWQAQKDAEKCQLDQLRNLHEQKERQLCERIRQKELEMSVETSRLEQTQRDLEVQAACLRLARDRVYLKDEDLTMQEQVLMNRRKEWKDEREHETKLWERQQKELKSQVKRLKSFAADVEAQAKMNTKQQQALDERFEQITKRELAFQRRSSQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W554</accession>
    <name>A0A6G0W554_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_018519</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000339">
        <property type="protein sequence ID" value="KAF0722303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W554"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002064"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="7">
        <location>
            <begin position="121"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="269"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0722303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="279" mass="33153" checksum="1DD78E38CF24E1CB" modified="2020-08-12" version="1">MDLVLNLADEYILTPYVYPESMAEDDLLRQCISLYAITLLGGYALYLGFAYFSYVFLFDKEYMKHPKFLKNQVRLEIQVSCTSIPFMILLTLPIFVAEVRGYSFLYDDVDQYGYPYLVFSVVMFMFFNDMMIYWIHRWLHHPLIYKHVHKLHHKWLVPTPFASHAFDPLDGFLQSSPYHMFIFLMPLHKVVYLSLFVLVNFWTISIHDGLFVMDKMPKWFETIVNGAAHHTDHHLFFEYNYGQYFTLWDHIGGSYRHPSPFDGNGPLDDVERMKQARSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W5K8</accession>
    <name>A0A6G0W5K8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_018924</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000367">
        <property type="protein sequence ID" value="KAF0721746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W5K8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020433"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0721746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="101" mass="11559" checksum="92347AB67714C852" modified="2020-08-12" version="1">MSPTAKSEDTKQERIVSRGKNFDIFKLRMRAILRSKGFWYIVNSSETPASDTNDPNIETKEAKAFDLLVNAFDDENLAYVVHVGTLSEAWNLLTNRYEART</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W5N3</accession>
    <name>A0A6G0W5N3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_018452</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000336">
        <property type="protein sequence ID" value="KAF0722383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W5N3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014737"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0229">DNA integration</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="11">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="229"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0722383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="382" mass="43990" checksum="4FB480C2FD08B77A" modified="2020-08-12" version="1">MRHPSISNRARYFITFTDDYTRYGFVYFLKHKLEALQHFQAFTAFCRTQFNRQVRCLRSDNGGEYISHAFSTFLTENGIRHEKTVPHTPQQNGVSERMNRTLVECARAMLHYSHVPLQFWAEAVAHAMYLRNRLYSSFTPGTTPFERLWKSKPDLSQLRIFGCEAYSRSKFASRTIRAMYVGNEPDVKGYRLYCQKFFVSRNVQFNEANSNFANSTSPLLLPAQDIFADEDSPRDESPPPPRRSTRIRRPPTRFMDTTPVIQPAASSPPQSSSVSTSELHEDVIDDSVSNAQEDVNTMIEDTSTSIPVALEDSEDMDVSTIYDAPFLRRRPREETIDEDFETEDDIIVSKRQRILVAFAVHSTGLPTTIQQAHSSPEREEWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W660</accession>
    <name>A0A6G0W660_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate dehydrogenase assembly factor 3</fullName>
            <shortName evidence="6">SDH assembly factor 3</shortName>
            <shortName evidence="6">SDHAF3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_018312</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the complex I LYR family. SDHAF3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000330">
        <property type="protein sequence ID" value="KAF0722579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W660"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002289"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006105">
        <property type="term" value="P:succinate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20270">
        <property type="entry name" value="Complex1_LYR_SDHAF3_LYRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008381">
        <property type="entry name" value="SDHAF3/Sdh7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13137">
        <property type="entry name" value="DC11 ACN9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13137:SF6">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13233">
        <property type="entry name" value="Complex1_LYR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0722579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="103" mass="12129" checksum="9D870B111E761692" modified="2020-08-12" version="1">MDKSNVLALYRGILRLHRQKLEPVMRVLGDRYVREEFKLHKNAKPEFVKGFLTEWQGYHDMLLTKETHFGQDLSVDHRRLLDDEQKKKLQDLHTAATKAGDNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W7L3</accession>
    <name>A0A6G0W7L3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_017890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000314">
        <property type="protein sequence ID" value="KAF0723143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W7L3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017982"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827:SF1">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0723143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="190" mass="21177" checksum="725421A1FFF90311" modified="2020-08-12" version="1">MAIDNSTASTPRRNRRNCIVPDCPNQAYARQLCCRHGAKKTCSVPGCDLRARTHGICFTHGAPKSRCDEPGCNHPAQARKKCVKHGGGRRCTAHGCTSHARYKGKCQRHTATDTPVDMMALWGTPNDDTTTTTHRRSYSIDSTDDVAAVDIAPCQLLDDIMTEYLEPLDFKRETCRDEMMMEIYSLLVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W7M7</accession>
    <name>A0A6G0W7M7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_017776</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000312">
        <property type="protein sequence ID" value="KAF0723257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W7M7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018351"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="START" evidence="7">
        <location>
            <begin position="100"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="272"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="369"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0723257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="381" mass="44061" checksum="33B28DFDE2B34647" modified="2020-08-12" version="1">MPVVEFPLPPNYFKCPPLSQYEIDQYTEIGRQSTHALIMKAKLQGGTYDWKLLKDHSELKIYKGHSHGSTNDAVLHCGVMEVIGELDECMELHRDDTTEEAREFTQWFGRAYMDVVTLYTVLPRHPDRPNDCIKIKWFLAKSPLNGLVVKRDFVMLESSLEFQVDGKRAWVRSYRSIDLAAVPDMRREFNCIRGSMYDMGYVMVESDRPGYLHMTYLADIDIKGKVPTWAHDHSLKFWLRSMFEVDRFLRENRLSRTLLLSKDQLCPLHLRNSCALCRRKFGPLRKKTNCFKCGEVLCRDCNRIWNVRVNGQPAKIRACVTCSLSNTPPPKRRPSWPAYGSMTPLRSTHLASTAGWSMDLDFEDHRDSTPTPGLTRTLTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W829</accession>
    <name>A0A6G0W829_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tesmin/TSO1-like CXC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_017846</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the lin-54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000313">
        <property type="protein sequence ID" value="KAF0723229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W829"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004942"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005172">
        <property type="entry name" value="CRC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028307">
        <property type="entry name" value="Lin-54_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033467">
        <property type="entry name" value="Tesmin/TSO1-like_CXC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12446:SF34">
        <property type="entry name" value="PROTEIN LIN-54 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12446">
        <property type="entry name" value="TESMIN/TSO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03638">
        <property type="entry name" value="TCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01114">
        <property type="entry name" value="CXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tesmin/TSO1-like CXC" evidence="5">
        <location>
            <begin position="147"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0723229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="260" mass="28637" checksum="CF03E1EDCD610A8E" modified="2020-08-12" version="1">MATTPLRPISTHQDAMKGLKQTSSLKRKPLATLSTNVLAQEEAERGTPVKKRKTEEWEDADIDNPTRRDEVNMAWLDMCCALLTKKRTDLPTKVIDPTDQLPELDLPCKGTPSKPRTISPVPSQDEVDPRDVDVINAAKTLHEQSQPSVTCCGCKTGCLKLYCRCFLTRGFCTAQCSCATCLNTKTSAQRLPAIIMHLKNNINAFRASSHTTPQNPGGNTDHGSMGLGSKFVPMIPNVKYRCTTGFDVNIGPCEWSYVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W856</accession>
    <name>A0A6G0W856_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_018067</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000319">
        <property type="protein sequence ID" value="KAF0722992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W856"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0722992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="169" mass="19061" checksum="461719C051B7C722" modified="2020-08-12" version="1">MVCRYRKDIELMFDMRWNDPKAVIILERSPFFVNNFLTTIAIPARLNLFPPVSLDQLCDLQRSSASFCQHILLQAAIAFNPVLGHCRDVFLLLFTRSAQTQADILTVPRSKGMLSHDYGHPSTVLQLCDSLIELFNASASAHGCLLAHFEGYAKERPSSIAHVPQECRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WAS2</accession>
    <name>A0A6G0WAS2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_017714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000309">
        <property type="protein sequence ID" value="KAF0723374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WAS2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011619"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0723374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="121" mass="13235" checksum="26EB03D86BC8AF2D" modified="2020-08-12" version="1">MSGDGSDETNDIVLARDEYELLQAFHRLIPVPALSCGLTRVLCEDELQVSDEPDDDDEPDDDDEQQNEATIPSKQASHVGALRQLRSTGGSAGKTAKPHHGTLDLSKFTPRQQPPQRPETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WC29</accession>
    <name>A0A6G0WC29_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Ae201684_016383</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="VJMJ01000253">
        <property type="protein sequence ID" value="KAF0724985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WC29"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011898"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000315">
        <property type="entry name" value="Calcium-dependent protein kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000026">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="48"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="348"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="353"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF0724985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="397" mass="43837" checksum="F3441C444A3E7F08" modified="2020-08-12" version="1">MGCVKSSPIPQVPSAPPAAAPATTGGATSAPAELVTNEPQRHGFEANYTLGKKLGEGTFSVVKEGIQKSTGKKFAIKCIKKSGLSQEDLDALHEEIDILKKMDHPNIMSLYEVYTEAQYYYLVTEFMEGGELFDRIVEKTFYTEKEARDLVQVLLSAIKYCHDHNVVHRDLKPENLLLTSKKDDAYIKIGDFGFAKQDFNAGLTTACGTPGYVAPEILKGEAYGKSVDIWSIGVITFILLCGYPPFHDENQKRLFTAIKLGQYKFESPYWDEVSVDAKDFISKMLVVNPDERYTADQLLQHVWVTGDQISTVPLTKAIEELKKYNIRRKFKAAVRTVQVTTALSRALHSTSGEETPTGVPAAEATTEVEAEANGVDATDIKVTVEATPEQEPQAIKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WF89</accession>
    <name>A0A6G0WF89_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_015719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000230">
        <property type="protein sequence ID" value="KAF0725949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WF89"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006976"/>
    <dbReference type="OrthoDB" id="147975at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050404">
        <property type="entry name" value="Heme-degrading_MO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34474">
        <property type="entry name" value="SIGNAL TRANSDUCTION PROTEIN TRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34474:SF2">
        <property type="entry name" value="SIGNAL TRANSDUCTION PROTEIN TRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0725949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="105" mass="12336" checksum="13EF85A7C3D016F2" modified="2020-08-12" version="1">MTGRIRVLTERVMSQGFEPAVSRMMERVKNTVRRQPGLISVETLADVSDHHKYIVLSEWKTRQDYENWEKSEDFKACTSKINECLDMPGKKTRIFQTPKDDIFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WFC1</accession>
    <name>A0A6G0WFC1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_015600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000226">
        <property type="protein sequence ID" value="KAF0726087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WFC1"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0726087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="113" mass="12193" checksum="BCD555FCAC46F414" modified="2020-08-12" version="1">MTKPLLFASVMGRRFGLFNTASTVPTSTKESVLQMWLTDVSKAHKTGEEFIVAPRHGAASMSRTVPGHAFKATHSQRRKSSRGMGDLQPSLAFNVVRLKGGSGLRVSSAATEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WGY5</accession>
    <name>A0A6G0WGY5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_015305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000216">
        <property type="protein sequence ID" value="KAF0726417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WGY5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004617"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004618"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052050">
        <property type="entry name" value="SecEffector_AnkRepeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586:SF3">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0726417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="654" mass="75056" checksum="79A44C45EDFE5F65" modified="2020-08-12" version="1">MYAAYSGQIDILDMLHRRHDLKKCGQSLRETAAAGSQVDVLEYLRSVAYPYVFPNQEISAACQTINARVVQYFVTKFPEGCPNEDAFQQLARRGCTEILELFLPRLLIGRHLVHSMVCIAAVCGHVALATWLKAQVGEVQDAMYPSIRQAASTGQYEGMAWLYHAGLPHMSDKALDRTSQFCLEKVICARQWMLVWPIAAELRNRNMVDVIFRSFECINWQKDASLALQLLDYVDEEEALSSRRLGATLRLGLLALQTIFSKWILTSEELLHVVTICLALAMKNPIKQQLAILEWLVQLVQLEIVAHVFHEYGELALYHAISNDDARLISFLYKHGVVLEGDYILENGGADVISWYLGNVEYAVTGRDLINVVSRPNPAIFKFVHEKWAPLLEEKDRIETVCWKRAANDSHFELLHFLAMSFQRDHNDQEFGRFLIRTKQDVVRVIKRNSKSSFELLFPTWWPVWTDSNKKHLVDFAIQANLGHSKVLARLVAMPFVQVELHHVILAGRHGHINGNDSSAFLILFRARSMQEDKSTRMELLEQCIETAMFFRYETMIQALLAVEKLKFTINLGMAMEFHNDWQHYLVAFAQKSTVQVDKEVLLHLVRLSQRAYDEQWEPTLFQDLFKAWMESPCTESSDKEDADKILKLAQAHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WHF7</accession>
    <name>A0A6G0WHF7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">glutamate synthase (ferredoxin)</fullName>
            <ecNumber evidence="19">1.4.7.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">Ae201684_015210</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="18">Amino-acid biosynthesis; L-glutamate biosynthesis via GLT pathway; L-glutamate from 2-oxoglutarate and L-glutamine (ferredoxin route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Energy metabolism; nitrogen metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Nitrogen metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.7.1" evidence="19"/>
    <dbReference type="EMBL" id="VJMJ01000213">
        <property type="protein sequence ID" value="KAF0726588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004093"/>
    <dbReference type="UniPathway" id="UPA00045"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016041">
        <property type="term" value="F:glutamate synthase (ferredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016040">
        <property type="term" value="F:glutamate synthase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019676">
        <property type="term" value="P:ammonia assimilation cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00982">
        <property type="entry name" value="gltB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00713">
        <property type="entry name" value="GltS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02808">
        <property type="entry name" value="GltS_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000031">
        <property type="entry name" value="Glutamate synthase 1 [NADH]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.60:FF:000001">
        <property type="entry name" value="Glutamate synthase, large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000001">
        <property type="entry name" value="Glutamate synthase, large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000314">
        <property type="entry name" value="Uncharacterized protein, isoform E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.60">
        <property type="entry name" value="Glutamate synthase, alpha subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050711">
        <property type="entry name" value="ET-N_metabolism_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002489">
        <property type="entry name" value="Glu_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036485">
        <property type="entry name" value="Glu_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006982">
        <property type="entry name" value="Glu_synth_centr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008730">
        <property type="entry name" value="PRK11750.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11938">
        <property type="entry name" value="FAD NADPH DEHYDROGENASE/OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11938:SF133">
        <property type="entry name" value="GLUTAMATE SYNTHASE (NADH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00310">
        <property type="entry name" value="GATase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04898">
        <property type="entry name" value="Glu_syn_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01493">
        <property type="entry name" value="GXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69336">
        <property type="entry name" value="Alpha subunit of glutamate synthase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0288">FMN</keyword>
    <keyword evidence="16" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="12" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="21">
        <location>
            <begin position="48"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="942"/>
            <end position="968"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00037928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00039085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAF0726588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1552" mass="169279" checksum="2D67024275CD0114" modified="2020-08-12" version="1">MLRAKLRRHLLAPRSSALSTYSYFRQPKSVPRATTPLLYKRDHEKDSCGVGMLAHLEKKPSRKVVVQANEMLVRMSHRGGCGCDPASGDGAGMLVGMPHMFIQRLIDEGAFGPNRIALEAEKYAVGNVFFAKNSQHIDASKKQFESLARDLNMKVVGWRSVPTSNADLGQTSLASEPTIEQVLVLPPPGLSNDHFEKELMRLRKVSTNMNKASEMYVCSLSSQTLVYKGQLTPGQVMPYYADLQAPDFTSYMALVHSRFSTNTFPSWDRAQPYRVLCHNGEINTLRGNKNWMFARGSKAHSSYFGSATSSLLPVCSDDMSDSGNFDSALELLTKASSCNRSLPETMMMMIPEAWQTNATMPEAKKAMYQFNSCMMEPWDGPAMVAFTNGKTVGASLDRNGLRPSRYYVTKDNHVVLSSEVGVIEGLPETDVASKHRLEPGKMFFVDFDQGRIISDEEIKTTVSTSRPYQEWVKNMVHFQEVGKKVSDIKPVVSKDFTRRLNIFGFTTETMEMLLIPMGLEYKEALGSMGNDAPLAVLSEQPKLPNEYFKQLFAQVTNPPIDPIREDLVMSLRCPVGPEENLLDVSPDHAKRLIVDHPVLSLEDMQKLKRGMMDPKWRAKTLDATFPAYSGVTGLQKALDRLCEEATTAAAQGQAVLVFSDKGAGAERFPIPSLLVIGAVHQHLLRTQQRTSVALFAECGDAKEVHDFATLLGFGADGVCPYMAYSALTHMNNEGLLEAIAKRKLEPSELWANYQTAVGKGLLKVMSKMGISTLQSYKGAQVFEAVGLGPDVIDRCFYGTTSRLQGSNMATLYDDIARLHEAGYPVHAIDAPLVRNPGQYHARENGEFHFNTPSAIVALQSAARTQSRDAYAQYRDLTNAASKRVTLRGLLEFKTVPEEKRPKWEDMEPIAEIVKRFNTGAMSLGSISRETHEALAVAMNQLGGRSNTGEGGEDPERYIPQADGSHNPKRSAIKQVASGRFGVTMHYLSNADQLQIKMAQGAKPGEGGELPGHKVSPYIAARRHTTPGVGLISPPPHHDIYSIEDLAQLIHDLKNSNPSAEISVKLVSEVGVGVVAAGVVKAKAEHITISGHDGGTGASSWTGVKHSGLPWELGLAEAQQTLVLNNLRSRIKLQTDGQLKTGRDVVIAALLGAEEYGFATAPLIALGCVMMRKCHLNTCPVGIATQDEELRKKFTGMPEHVVNFLWLLAEDIQGIVRSLGATLIDEVIGRADLLQVDKSSLHRKTALLDLSPLLVNAQSLNPESGIRYNPKDQQNHELDDILDQTLVQQCQAAIAHGTPAKVQLPISNVDRTVGALLSHTITKRYGVEGLPANTIQLDLEGHAGQSLAFGLAPGIQLKVTGDANDYVGKSLSGGTVIVTPEVERGEGQTIVGNAVLYGATSGSAFFRGRAGERFAVRNSGVDAVVEGVGDHGCEYMTGGRVVILGNTGRNFGAGMSGGIAYVYDPVGDFATKCNHAMIGLETIADPSDQASLRDLLQQHIEHTQSTVASAILADWSRTQHNFVKVMPHDYKKVVESLSVQAPEEPAQQTVMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJG7</accession>
    <name>A0A6G0WJG7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_014630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000198">
        <property type="protein sequence ID" value="KAF0727371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJG7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020668"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0727371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="212" mass="24447" checksum="7E712DA19F293BD2" modified="2020-08-12" version="1">MENAIVLSTGPQADLLAFHHAAKEGDIQSVQAWLRRHENVNASLGDGWTALHYAIQYGQMVVFQVLVQCSIVDLNAKTICGTTPLSMALRRQNDIMADMLLNAGASKAAIPFSEIYQLQQRRHGLPGTLRYKLSSYWSPMWKPDMHRRFPLQQRQVCYVLLCANARNRKRQCGILQVITHAFFRRPPARQCTWRYLPPPILQSIFEFYFWLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WK97</accession>
    <name>A0A6G0WK97_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_014300</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000191">
        <property type="protein sequence ID" value="KAF0727674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WK97"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009150"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052032">
        <property type="entry name" value="ATP-dep_AA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005543">
        <property type="entry name" value="PRK07206.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43585:SF2">
        <property type="entry name" value="ATP-GRASP ENZYME FSQD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43585">
        <property type="entry name" value="FUMIPYRROLE BIOSYNTHESIS PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13535">
        <property type="entry name" value="ATP-grasp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="5">
        <location>
            <begin position="134"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0727674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="467" mass="51480" checksum="62697299637E8F91" modified="2020-08-12" version="1">MPNTCSVATRQDCVVVVDPFSTGLCLAQDVMQRGYACIAVYSETEQVFADWMATLSSDVRKSFAGEVFHDGSDTSDAQLDRVMRDVLSFGFNVVGVIVGAEPGVHLCDRLSEKMRLVSNGSALSEGRRNKYVMGETIRAASLRAVKQCLASTFEEAQEFVVNVLKPQPFKVIVKPVDSAGSDDVTLCKTFEDIRDCYRNVIGKINHLGIENTALLVQEYLEGTEYVVDTVSRQGEHKIVAVWEYDKRSANGAAFVYFGAHLREAKGKTILSIIDYTCKVLDALGINNGPGHAEVKYVHGEPCLIEIGARCHGREGTDMPILDRCQGYNQVGATVDAYFDKVAFDALPKMPTTLKAHGIKTTLVSYELGVLHSMPGLSEIEAMASYVDKKIRHSEGVRIAPTIDMFTTPGCVLMVHADLTTLTQDYERIRELELKGLYKLKKEEPITTKKTARYSAEMDVRTVQVASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WKC5</accession>
    <name>A0A6G0WKC5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_014345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000191">
        <property type="protein sequence ID" value="KAF0727722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WKC5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006458"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0727722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="508" mass="58310" checksum="CCD165677D3EC7F6" modified="2020-08-12" version="1">MSQSSIVDIQARAATSTELFTLADISSVRNWDYTLPTLTRPHRFTERKAWTNASFFETEFFELYPVLKKISLDNLALMGGSVLSLLTGVFRSKDLDFFVVTDQPELSKEAACEYAHNRVKKFIRDVYTFMVTSNESLKQLQEETQKTKPNFKVDDYKFYKLDDFRVRRVLNVYTITVPQIHNSRRCDVATIQLITTPYTSVAELVQHADLSCTAMTYYNHEVWFSERAKFSFENLCFVVDGATADMDRVIKYFDRGFDVIMPHLDETKIRTHNFQFGVAEVLDLPYLTIVVNQLKDKKIFLTSMAKCERPPESDEAPAAWTRTSFSTYDQAAEASSLDVGSIIHYNIICLIHGNNDGLVVHGEGASYENAFRPRPYITERMLVNSYETVRNSLYNSNSLNLEKLLKYFTVWKPSELLNRLVLSYVAEQEAKGRPGVSILEGTEFEKHFKNVVDELVAQQIVIAKQKIAELEGTPASTLEVQQRFSNGMTPAKFFGRYYNDSEHLQRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WKT3</accession>
    <name>A0A6G0WKT3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_014164</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000186">
        <property type="protein sequence ID" value="KAF0727900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WKT3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010589"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF18">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0727900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="304" mass="33667" checksum="B665A7966C1A3ADE" modified="2020-08-12" version="1">MHEIYVFGGTILTMSILGADYTQTNDLWKLDTVAEKWSQVQVATPVAPIPRSEATAVAVGNDSLVVFGGVVVPTINSYPIDLSDLWSFSYDAKTWTQLGPTNKLVAPLTRSHASTTLTVNGVLYVADVPQVWTELNAYPPFDRIFTQVLTGPSGVWTFGGLNFVGQNQDSAIAYADTIYAPSNNLPQLDLLYDYAVDLSTISARYNHRMALWHGHLIVYGGKFQSCLGDLWLRNSSFLPSDPSPYITNPATLSSIIFLLVAFLVLFFTSIFLIAYMYRRYRWHNGSRRTENVVLSGAAGNVVYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WLB5</accession>
    <name>A0A6G0WLB5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_013914</name>
        <name evidence="4" type="ORF">Ae201684_013936</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000181">
        <property type="protein sequence ID" value="KAF0728084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VJMJ01000181">
        <property type="protein sequence ID" value="KAF0728108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WLB5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003433"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08252">
        <property type="entry name" value="AL_MDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014182">
        <property type="entry name" value="ADH_Zn_typ-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052585">
        <property type="entry name" value="Lipid_raft_assoc_Zn_ADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02817">
        <property type="entry name" value="adh_fam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43482">
        <property type="entry name" value="PROTEIN AST1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43482:SF1">
        <property type="entry name" value="PROTEIN AST1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="23"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0728084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0728108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="348" mass="37372" checksum="C70978419F003054" modified="2020-08-12" version="1">MANIPKTMRAVGLNEHLPIDNPSSLLDLVIDVPTISGREILVQIKANGVNPADYKLRREPGEFTAPKVLGFDAAGVVAAVGPDVTLFKVGDEVYYVGPFTGLGANAEYQAVDERLVALKPSSLTFAEAAALPVTTLTAYDSIFYRLGVSKADPRVTSPTKKAVLILNGSGGVGSIAIQLLKELTDVTVIASASRPQSSAWVTELGADHVVNHAEDIPKQLAAIGIPQVDYILVFTDLPPHFTTIAEVIKPQGKICAITPITEDLPFQNLFFKSITFVWETLATRMILDVDDRIVHHRVLTEVRELVDAKRLRSIVGEDFGVINAANLKKAHAALEGGHVVGKIVLSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WLG3</accession>
    <name>A0A6G0WLG3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_013968</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000181">
        <property type="protein sequence ID" value="KAF0728142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WLG3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018806"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005629">
        <property type="entry name" value="Skn1/Kre6/Sbg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361:SF1">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03935">
        <property type="entry name" value="SKN1_KRE6_Sbg1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0728142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="759" mass="84275" checksum="B29B708387019DC0" modified="2020-08-12" version="1">MKRRIQWVATSVALVVGLDYDFDGFPAKSGVGIWIDVDTPASARQKQTSRGETWQLVMSDEFEVDGRSFKPGEDHLWTALDMPDGVNAALEMYSSDNVYTKGGKLINKVEEGSTVVSYFNQWLENPGWETRTMYYTAGMMQSWNKFCMQGGLIEVAAKLPGAINNVTDSEHKSITINPNALGYTIDSKTGKKTILSPISRILDRGYYPTWPGIWLMGNLGRALFTVSTTRVWPWTYNDCDAELEPFQLISACNATPGYGLNPNQGRGAPEIDILEGGGDAISSSIQIAPGMPDDYRRVPVVKGGPDTDPRTNYTNIYCVYGKGCSTPGANIPDAPWSAFKSRGHKNWYQGLRYAANNRCELVPTDIQNFDVVNQSQTYRDRITSNVYEMTQMSAARDVNADLSFIDGNTSLHWGINHNGAYYPIANGYIGAFLCDPDAKNPKCETPRKPGVADTHQMAKFEYQMDAISVNWAMGHEAYTTFYIYQVEWVMGPSGYIRWSLAGSPLFEIPAKALTSPPQGNKTRNPKKIMIEEPMYLIFNVALAKAWGAMPPNVDIGPCRGNATQPEPGSWAYNQSNNICDSFPMYMEIDYIRVYQNKSNMFVGCDPPTHPTKKWIEGHINWYTDDKNPVLPVHGRASCNVDDDCTQDNKMAPPTGRCVSRRCVCVKGYTGPRCTKQITDVEEFGPNLVYPSVLASVCFAALVLSCVARSHRMAKASTIATVSTKRHGEVRQFEDEDGIELSAPSATRRYYGPANPSSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WMR4</accession>
    <name>A0A6G0WMR4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1640 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_013562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000175">
        <property type="protein sequence ID" value="KAF0728601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WMR4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010919"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0728601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="25856" checksum="F109A8B389EEAE2D" modified="2020-08-12" version="1">MHRSVRGIQVAVRAARPRWPRALLSTSSPTDMNPCPREEVTPQTLGPVIDVVDSQTQALSLLEEENHSYSERVHVVSQLQRQGYSAIQAQGLVDAMKASFNESIDVQMAVLTTKAEHVALKSEILERVFNSTLKFDIAQRNMRDFLEHDFVTLKQDIHMMEKLDFEAVRNEIAQVEAKFLQQKEASDELFDNLVKANARLEKRILNYVAAFGSTIAIILAVLSSIIDKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WP34</accession>
    <name>A0A6G0WP34_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_013108</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000167">
        <property type="protein sequence ID" value="KAF0729130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WP34"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012094"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0729130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="220" mass="23353" checksum="F816139D4563E30C" modified="2020-08-12" version="1">MSRSTTRYKRNGANKLLILPFAFDMFASIVTLAAIALSAVSAGSLPDIEAQFNIWLQSPAGQAATRLQVIPPNAVNNPTLLARFSAASSPTEAALALGHELLVASWPALPTNERASWLQIAAHENLLRTVESDPADTSKLYLSVASTTSPYSILCANPPFCLHRVNVSASAAAILDNPFVLLTPSETTTYLDDAFSSGAVRSALLTVEDAPVLLLEFQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WPJ5</accession>
    <name>A0A6G0WPJ5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_013024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000166">
        <property type="protein sequence ID" value="KAF0729277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WPJ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016696"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0729277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="129" mass="15386" checksum="5575BBCED4384D45" modified="2020-08-12" version="1">MQHILFDCKFVKPVWNWHQAAWRPFGIPFTWNTIINLDEFAVSEEWVPQFSVIRRFWVLLVSTLLRDFWIHRNRTKFEGKPVPYIQAVKEVSLVSWTASIRRTLRDPTNDSDEAMQVSEIVDKLKSHTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WQQ9</accession>
    <name>A0A6G0WQQ9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_012676</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000161">
        <property type="protein sequence ID" value="KAF0729785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WQQ9"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0729785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="67" mass="7720" checksum="3395485FA25B3880" modified="2020-08-12" version="1">MSWRTAWFHDQLEETSWCGQSLLQESTPPFLLEASLCPMTSLTTWRSLSCASRRRRSDGKGQSKILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WR17</accession>
    <name>A0A6G0WR17_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_012619</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000160">
        <property type="protein sequence ID" value="KAF0729836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WR17"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0729836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="119" mass="13630" checksum="7F01581B0950BA7F" modified="2020-08-12" version="1">MHRGTFNESHRAFQTSTDFVQVRIVVPCARKFGWSDEDVDAWRVPTPQGDDQPTVGQLRAFARLRVDIFFVLFSSCDEETTDDLKVPVNEHYNSFVSKFGCLLRAFFDIPDLGQNTVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WR48</accession>
    <name>A0A6G0WR48_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_012539</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000159">
        <property type="protein sequence ID" value="KAF0729899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WR48"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006137"/>
    <dbReference type="OrthoDB" id="256303at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000190">
        <property type="entry name" value="Nuclear pore complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="72"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="114"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="255"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0729899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="350" mass="38732" checksum="D473C3AA0406ACBF" modified="2020-08-12" version="1">MSFGGFGSAAATNPTSRAAQDYDVPPDVPDSIQDIAWSPNANILVAGSWDNHVRCWEVQHQGANFQAVARAEITHKAPVLCTAFSGDGTTVFSGSCDKTAMMWQLGGSNQGQQIAQHDQPIRSIQHIAQANCVVTGSWDKTVKYWDTRAPQPQATVQLSERCYALDVSYPLMVVATADKQIHCFDLKKPSQIYCTLKSSLKYQTRCIAAFPDASGFAVGSIEGRVSIQHVDEKMKEKDFSFKAHRDNTTNSIYPVNSISFHQNSGRIATTGADGSYAFWDKDARKLLSNFAKLPNYQGISVGKFNKTGEIFAYATSYDWHKGVEHYNPQARNVLRLHYVDANDMTIKTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WRY6</accession>
    <name>A0A6G0WRY6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_012243</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000155">
        <property type="protein sequence ID" value="KAF0730241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WRY6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019183"/>
    <dbReference type="OrthoDB" id="10255013at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15848">
        <property type="entry name" value="SNARE_syntaxin1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF307">
        <property type="entry name" value="PROTEIN SSO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00804">
        <property type="entry name" value="Syntaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00503">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="8">
        <location>
            <begin position="198"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0730241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="295" mass="33310" checksum="5780EB443D478C88" modified="2020-08-12" version="1">MHDRLAELTGKTDVAIDVVPENANVARPKFMEKFFLDVEEMQADLGKIAIATDRIAELNHQALIATASGEEQIVSQELCLVIDNTNKIAAHAKALLELIKKETADKKKDKNVPASEMRIRDNMSTTLTRKFMDTMKDYQKAQQKFKSDMKNKVKRQVQIVKPDASEQEIDMVMRSADPGAIYRSAILQGSNDSIKEVYMNCHDKYQDVLKLEQSVAELHQMFLDLALLVEQQGEMLDQIEFQVKTASNYIDAGNKEVTKALKSQKSWRKKICCLLFFGLIIILIAVLASGAFKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WSG4</accession>
    <name>A0A6G0WSG4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_012365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000155">
        <property type="protein sequence ID" value="KAF0730372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WSG4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012505"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0730372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="426" mass="47579" checksum="4E357AA8E4417CA6" modified="2020-08-12" version="1">MSDEDEVTYDIHADGSSKLTKSLQKAKQRSQKVRQVDPTPNVVESPKTQNPTQFARISSYLLETEGDSGDDEDDDFASILQIQTPAAPPAAIHAVDPNRPQTPERHLNLSPQRPSESQRTSASILRSITTANTTAPSQPRRSLLKTTPRKTPRAAFDAAFDRPSHWLKSPPAKPLQMRTRNPKRTQTTPPLLRNPLPTSTQIGKSMADVLRQATSGTNERLPQTPRRNPFEDIEDAGLGGPTQPGFQSPQQLPFVLPPKEKRRKRLSEVTIAGEIGQVLQRAARKASRDTTLFHTNSHQTLANAAIDAPHNRPHISLCLLRTRLHEGFVIFSAYIHEVSDEAYFSSLRLEPPLLPIRRRVFVDAVFPKDSMAHLRDNVLVMIYSPFHILSLDGPYPFPLLLGTHLFRVTDANHECQTSLPFDDDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WSQ0</accession>
    <name>A0A6G0WSQ0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator complex subunit 15 KIX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_012149</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000154">
        <property type="protein sequence ID" value="KAF0730449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WSQ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015941"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036546">
        <property type="entry name" value="MED15_KIX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16987">
        <property type="entry name" value="KIX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mediator complex subunit 15 KIX" evidence="3">
        <location>
            <begin position="6"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0730449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="330" mass="37661" checksum="97B6EF84BCC9C4F9" modified="2020-08-12" version="1">MIDALNWRLTCRQEDRQSMIMQLCQVLLRATREDDTAKVWQSASKYENTVWIQAKNLWEYNLLIQTKLQNLQQQLTSNITSNTTSQSSWTTMEKQFNQEMADLSLKQQTAVENLHQSQLTERNQVVANLYERKVSWDIQCWELAELTYRHKLALLQLEQDHLSQQKLVIQRHLQCFASEVSSSAPNSCQMSNSGLHDEVNLSGVTPSPTNHFNPKVMNEAKTALALLRDQHTNTVQKTIVVVENILSRSNMQTAMSPASKTKLEKSLQGMKHILRALASNSDQIDTEKIERYITTVVKPLYARLSQTQSTKTSAVAIVIPTPQMQVMGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WSR6</accession>
    <name>A0A6G0WSR6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MAPEG family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_011954</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000153">
        <property type="protein sequence ID" value="KAF0730531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WSR6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015897"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0730531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="23637" checksum="57252D91ACC08588" modified="2020-08-12" version="1">MGSDNGTKVSDSGLPAMTDAEKKKNTLPIVGAFTMVPLAIGTAIAYGVYMWGARATFEKRIQAFVANDLHWAGLAVVVLGRTITFVNGYPMVFKSQIMRADSGNLRSNPFIYKMIGKDAKDNAVVFNDEGAIGAYNRANRSLHHMIENYGALVAGLALASQVFAFPVFVAVCIFSVGRILHQVGYTSGYGGHGLGFGVSMLAIATIEGFLLFIGLKGLKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WSV4</accession>
    <name>A0A6G0WSV4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_011991</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000153">
        <property type="protein sequence ID" value="KAF0730569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WSV4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004442"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070840">
        <property type="term" value="F:dynein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051310">
        <property type="term" value="P:metaphase chromosome alignment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010389">
        <property type="term" value="P:regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043513">
        <property type="entry name" value="Cenp-F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18874:SF10">
        <property type="entry name" value="CENTROMERE PROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18874">
        <property type="entry name" value="CMF/LEK/CENP CELL DIVISION-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="964"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1092"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="170"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="290"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="393"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="548"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="727"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="921"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="988"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="29"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1094"/>
            <end position="1106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0730569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1113" mass="122833" checksum="68E913FDF1BF4598" modified="2020-08-12" version="1">MRATSRPSSAPPSRLPTSPTAKSKRTSIPAPTTSTGSPRRSPTKSTLNSSPASSSLTSPKANKTLSKQQTTKITPPPPPPQSTTRATTDKAKPATPHYLKTTKASVVQSVAKSNATSTKATGGASKKPQAVAAPSPIDLTVQDMQATLNEHISQQTSSLQRQLDDAVARNGQLQLQLDAAVMAKQELEDALEKTEAANADFAKACARYKADCESFAAKAIEWKQKYDAMATSSKLLEQRKGAAAKSRAMEKRIQYLAQDVAHTAEAVGGTSVMDYKIHAVPEGDEDEANFERCESHLDALQKELKRLNERVKGMDADGFAKMEQALADAKALAAAREGDLVDMKAKLMHLAKAHCAETDEALAKVAALEAQRVEDARAFDAERMASEDAHGQLERAEQSLAKLRFDKQLLAERFAALQTAQRETQARLDDLDETKARMKKIKHLKDELAEATAHNSSVDNVDTLDFSVAHAALQDECVRLQETTEEQRQFAASQELVVGVLQKELNLMMDTVQQLRDAAASALERQPSSPKQQQQQQQLGRELYLAAIEAYALEAQAKHEEVQALRAKVDDVAVERRGLLEKIDDLEQQARGEREQLEENFQALSNEKRELEAQVEEMQATMDAMAMESKDLKEQLASSRYNLAKVERKSAAIDDDMLEIHAEKQTLHDALKQSTDQVAALKSQLEAQSATAAELKARLDATTKLTHDLAAQVKHFPSREEKLRFVIEQLEAQEAAADAKQTELDKAIATMEETIQVLQSEAETSLEEIQQLLETQRALEMQLATAKMENSSLQELVTKVQVGSTRLQTIMEQDKEELIDSYVDEVGRLQKRIDKLEKNAEDDAERTQTLAQERDEFERACRDAVQKCVKMDAAWKRAQESAAASEKRVHALEAELAAQVASLTRALDDKTTVVCELQANAAALEAAVATLQAEKAQYKTEVHAIEAILHENSPLQKTVDVLSNAKQDKARSPKSGASGKSKSPHTEIKQLRQRVKDLEMEKELLQAELEQANATRASSKHKQDAALYAAQVEELEEKLAEQTAMYLASVKQAQQEYKELEGQYQAKIRHLEMELHLDEARIEALEGRLAETLSSRQSSAAAATSPAHRRSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WUC4</accession>
    <name>A0A6G0WUC4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SAM-dependent MTase RsmB/NOP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_011603</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000147">
        <property type="protein sequence ID" value="KAF0731055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WUC4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004589"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21150">
        <property type="entry name" value="PUA_NSun6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807:SF34">
        <property type="entry name" value="TRNA (CYTOSINE(72)-C(5))-METHYLTRANSFERASE NSUN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="6">
        <location>
            <begin position="138"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="238"/>
            <end position="244"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0731055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="478" mass="51965" checksum="E7F58CE97BBF8CB2" modified="2020-08-12" version="1">MDVKLDDFVLSFPPDVEAFFADAYGQDHWNKIKAALARPPAYTSVRVNTLVTTQTQLVESLNAALSDFNARLEKQGRPAIVAVPHKSLDDVVVVPSAPRVASTDVPQKKIIVDRLCGEAVLRGSDIFARGVMCASTAMNAGDEVAIYVDLDHSATRGSDAELHAGRKILIANGKTDMPRSEMFRALKGLAVTVTSRLCADAPPLNGVLSGSMYMQNTPSSVVAHVLDPQPGETIIDMCAAPGGKTSHIATLMQNKGTLVACDRSRRKVLEMKSFFESVNLSCIVPIKLDSTQSVLPKQDNVITVQEIIELSKNKDPKAKLLPIEGFCAETFDKILLDPPCSALGLRPRLLHACDLPELEQYSNMQRNFLWAAAFLLKPGGTLVYSTCTVNPKENEYMVRHALDTYPLELVAQTPFLGETGLTNQVLSPEEAARVQRFDPSSSSDTMGFFCAKFIKTRSIRDISPTTQPATPTTAEAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WV67</accession>
    <name>A0A6G0WV67_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_011277</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000143">
        <property type="protein sequence ID" value="KAF0731374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WV67"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006531"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013209"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF37">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13456">
        <property type="entry name" value="RVT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="10">
        <location>
            <begin position="413"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0731374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="777" mass="87722" checksum="D2B9962FE9D8F317" modified="2020-08-12" version="1">MLANFHAMQWFLSLDNASGFWVVRATKRARKVSAFICALGHFEWTRMAQGLKNAPMIYQRMITSALFGFVDMPPGVADEDADGEPVDMFALGFKCDLSQLPPPANRTSFADDISDGADSWEGIVELTDRILARLTYFGVSISALKSKFGKIATDFLGHVVSRRGLEARPRSLDAVLAAPFPKCLRDMQSFLGSLNFYSRFIENYSILASCLYEISDDELRLGLVSPAAVRAFADLKAAYSSTPLLRHADPEREFHVLLYTTTWAISATVCQDYDGVLHPVRFCGRTLKGGEPRYEEWAKEALALLRAVKVCYYELRNMQLVVYSRHDLLKWILADKHGKADHLPWAAILSPWTIRVEQVVELDERWALPIRLMDILHPPDASTLADMDVYKPNRAKDVQVSQRQAALPQFGPDERATVVAFDGAIKAKEKVGSYGFVIWQLPGWSVLWAENGVVADATVNLAEYNGLIAALERVLSLSVVNPVIFGDSRLVIHQVLGWMQSKQSHLQNCLDRVRALRDQATGVEFHHVKREWNGAADLLAGLALQDRAGGQVLDESILEELQRRNLLPELLHSATTAVPPMIMALQAKSTEKMAALRLDRVSKAQDRERELANIKCYLRSEVSHLTEAECRVMSKLAGQFEIGEQRALYRVEWSSKRSPEERMQWKLVIPRALVKVVLAHCHDDAQGGHAKFQRTYDDVLGSRPQVVAVRNVRYTEGTKEYEVQFHRGGPWIWEALVNIPPTELIYEFERVRLGFDRLAMMVQEELEEEEVKDDGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WVH9</accession>
    <name>A0A6G0WVH9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_011269</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000142">
        <property type="protein sequence ID" value="KAF0731475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WVH9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004520"/>
    <dbReference type="OrthoDB" id="433512at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="330"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="398"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="6"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0731475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="478" mass="51816" checksum="7FD1771663675C02" modified="2020-08-12" version="1">MVPWSKFLVRGLGFFNDAYDLFVMNVVNVVLEEQYGSDVYTPALKGAVSAAALIGAVIGQIVFGYLADILGRRINMIITCGILILGGVICALASGGSPTNTLWILVVARGILGVGIGGEYPLAASASAEDASSVTERNQRVALTFSLQGVGCLTAAIMGNLYVAAYASGPRGSASKGDLEFIWRSLFGIGIIPSALVFFFRYRAEETVAFAAQTNQQSKRIPLMFVVKVYGRWLLGTAGTWFLFDIVFYAQNLFSATILSVVGITEPTLMHVTTQNILVACVALPGYYVAVYFINRVGRRMMQVQGFVWMTLLFLILSGVWNDIKQDTTSFVLLYGLALFFSNFGPNMSTFVLPTEMFPTPIRARCHGFSAAMGKLGAAIGSYGFAATGQNSDSIGTTFGVFAFFCMLSIPLTWFCTFDNPNPLSDGDAEFDRRLRIYIGAALQDEDFTDVDETIDEEIEVDIGSPLQVKNESSNVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WWT4</accession>
    <name>A0A6G0WWT4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="19">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">Ae201684_010903</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 19">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>Na(+)(in) + ATP + H2O = Na(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:14634"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 19">Membrane</location>
            <topology evidence="1 19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="19"/>
    <dbReference type="EMBL" id="VJMJ01000138">
        <property type="protein sequence ID" value="KAF0731952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WWT4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002642"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008554">
        <property type="term" value="F:P-type sodium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000110">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000014">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF150">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 18 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 17 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0915">Sodium</keyword>
    <keyword evidence="13" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="9 19" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="895"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="928"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="977"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1040"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1068"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="22">
        <location>
            <begin position="11"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="21">
        <location>
            <begin position="117"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="23">
        <location>
            <begin position="864"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1202"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1223"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="16">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="399"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="399"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="400"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
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        <location>
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        </ligand>
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        <location>
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            <name>ATP</name>
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            <name>ATP</name>
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        </ligand>
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            <name>ATP</name>
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        </ligand>
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        </ligand>
    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
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        <source>
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        <source>
            <dbReference type="Pfam" id="PF16209"/>
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        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1237" mass="138254" checksum="D46E35AB09689C96" modified="2020-08-12" version="1">MGEVKQDSRVVHVNNDTENERLRKEFKYTNNWVSTSKYTAITFVPKTLFEFFRVIANMYFLFISIIQLASDWSPTNKYTTAGPLIIVLIVSMVKQAIEDKKRHDADGIQNNRKCYILAADGTVQEKQWQEVEVGDILFLKDKDELPADILILATSEEEGRCFVETCNLDGETNLKRRTACEPIAKLIGFRALNNPVIDEQKHKESCKAFRGYIEYEQPNNRLYNFTGRVVTPSLADPVPIGPSNIILRGCSIRSCSYVFGIVLFAGRESKLMQNARSTPSKQSNVYKQVNRCIILIFLTQALLCVISALSYNAWVKANLELNDWYIPFLKTDPSAFFTFLILYNNLVPISLYVSLDMVKVAQAKNISNDMEMSHEGFNAIARTSDLNEDLGQIEYIFSDKTGTLTQNIMEFRKCSIGGTVYGYGSTEIAQAVANLAAKHGTASSLPPVDNGPGPAADLKDAQIFLDKTIHFDDPRLITEMKTNGSNSQNIREFLTLLSVCHTVIPETNTKTGVTNYRASSPDEEALVKAARCLGFKLVTPAPFVEVEVTLKGSPPSMKKYEILNVNEFNSTRKRMSVVVQVPDGGILVYCKGADNVIIPRCANKDGTALLEEHLKTFASEGLRTLVLAKRVLTSTEYEEWNKVYQAAATSLVDRDALLDAAAELLEVGMDVVGATAIEDKLQVGVPHTIFSLAKAGIKIWVLTGDKEETAVNIGHACRLLNDSMQLLFVNREDIAGLTDQLEYLYRMEAIQKHYKNKTVAEDIAIVCDGKALVHFFPSKTLSSSDQIKAKELRQKLLVVASVCKAMVACRVSPAQKADIVNLVRYNSRNKPITLAIGDGANDVNMIQSAHVGIGICGQEGVQAVNASDYAIAQFRFLQRLLLVHGRSNYKRIAKVILYSFYKNMALVIVLFLYNFVNAHSGTSVFESFVMAGWNFFLALPIIAIGIFDEDVSPEQAMSHPTLYTTGQRNDDLNIYRFSIWIANAVFHAFVSFLLPLAYVMGYPTHAFHLQGTTIYTGLLMTMNCKVILETMSWTSYNRGFIIFSIALFFFFLGVYPHCTFLSWDMWGIPSILLSSGIYWANFFLVPVANFLVDLSLKFWVKFYCPTEADILRERLVMGRHMSSKVSCDVSEVTKTQVLQQDPVAKQNSVQRTPEQIEADKRAGVRNLSDIQYTGFAYSSPNEEANERGHRDTASLKVDLLQQSGRRDEEKASRGQSAGHIDMQQGSATNNHAVTDME</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WX12</accession>
    <name>A0A6G0WX12_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_010768</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000137">
        <property type="protein sequence ID" value="KAF0732116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WX12"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001421"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="30"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
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        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="Pfam" id="PF00787"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAF0732116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="407" mass="44921" checksum="1647DC35DCA73BCB" modified="2020-08-12" version="1">MLLESVHVVRFDPSVEKGKKTVVYVTEVNSGKAKWEVEVRYSRFHEFHQELLKVDRKVMGKFPFPSKDLFANHSPEHRVEELDKFVVHLLDAYELLTPASQALFLELLEVAEHNVQEEERPENQADSKDDIPEKRVSKQSVSSSTTTELDEDNQRDSISESQLDDLHHEPLSPVQDGSSDDSPADFNERTEGLHEEVTPTDVPQQSEPQNEVEEEAEAPVSALVESTESSHAAVSARTVATVQEEPKQVEVAPEPLRSDDAIQVSKESSSPPDATSDSISTPIPAEASVKADIIASTTSTTTSVKADIITSTAPTTTQVNEVVSTVIDQVVDAKQSAAAPEESPASPKVQDNGPSVLFTTIEKYASKPEQSHPHHVWSLPNASKAHRYQCRHVVVKTIRVLYPSLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WX69</accession>
    <name>A0A6G0WX69_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_010809</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000137">
        <property type="protein sequence ID" value="KAF0732159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WX69"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001100"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF9">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="57"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="90"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="123"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="156"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0732159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="215" mass="23800" checksum="86EB0A82F9997AB7" modified="2020-08-12" version="1">MPRKDDHKDKSKGKRPLETALGTLKSKMLFWAVRKRDLRTIRSLLARGANADWRDPDRRTPLLFAASNGYLNEVKEILDHGASPDMGNEDGWTPLHRATERKHFKVLQELLSHGAAMDAADHHGWTPLHEATRRGYADIVVELLAHGASVDAATKHGWTPLHWASRNGFASILNQLLDAGANVELKTNDGKTAYDVGSDGMKKLLESRAQAAAKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WXG2</accession>
    <name>A0A6G0WXG2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transmembrane protein 135 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_010667</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000136">
        <property type="protein sequence ID" value="KAF0732222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WXG2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007609"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0732222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="354" mass="39632" checksum="E990ABC454FCBAB3" modified="2020-08-12" version="1">MAEAAVRHAIVPVCCTLAVGTLLSSARARQVKLPPTLFIALSAGCGVFRFVNHFRGNGNSKLAAWLASMAFFRLCADPHRHIVLAYGCVEVVGEYYAKRPFLSYLGEQTVVLASVIRLIYTFMTNPEWLPPSSRKLLDYQANIPISQMEIFRQNFHSGATTRCVAIHPNETCGSFAISRSVGLVERGVQIFVPLHTLSLVATMAARKTVHLDKAMDNLVRSIGFLFFAYSGPFFCSCMLPQKDHKVCLFIASATTYPALFVEPSKRRQSLQKAIMCWSLVSLVLQVKTWKLGQRLKGFPWSWLGAAAYAACMVKILAHPESHNQWVMRYLYGRDMKQEKEDEEPRQSKMLTGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WXR6</accession>
    <name>A0A6G0WXR6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA-intron lyase</fullName>
            <ecNumber evidence="2">4.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_010613</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>pretRNA = a 3'-half-tRNA molecule with a 5'-OH end + a 5'-half-tRNA molecule with a 2',3'-cyclic phosphate end + an intron with a 2',3'-cyclic phosphate and a 5'-hydroxyl terminus.</text>
            <dbReference type="EC" id="4.6.1.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA-intron endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="2"/>
    <dbReference type="EMBL" id="VJMJ01000135">
        <property type="protein sequence ID" value="KAF0732324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WXR6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002009"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22363">
        <property type="entry name" value="tRNA-intron_lyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13070:SF0">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13070">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA intron endonuclease catalytic" evidence="6">
        <location>
            <begin position="128"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0732324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="225" mass="25473" checksum="B61A9F6C24B40BA1" modified="2020-08-12" version="1">MVAVCMDGKVWSAADAKKLREEHRFVCGNGSICRENSNKAPADRIPLQLTPEQLYVGQRHCFLTQTSLNSQQESPTPSSEWWRSTWNMIASFFRQTTHTDEGSQKRRRIDPQVEQHRMEDTLVPLRHRIFLDLWEKGFYISSGSKFGGDYLLYDVDPLTSHAKAIVVVSECPVLSASELAGFCRLARAVKKTFVMAYVNDNQTVSYTTLVHVATTTRTTNGARPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WYW4</accession>
    <name>A0A6G0WYW4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_010252</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000129">
        <property type="protein sequence ID" value="KAF0732721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WYW4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010272"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505:SF79">
        <property type="entry name" value="PROTEIN SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="434"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="9"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0732721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="480" mass="52452" checksum="64E67B0BA1A7A9A7" modified="2020-08-12" version="1">MLIFDVRHVFFLLCTINVLVYVTRGIIPGAPVQFQAFIQDSLRVDPANVSFYIGVLTTSFVAAYCTFTSVFGYLSMAHRPFRLAGLCLFIWIGSMVLSGVAQSLDNFYILLVGRMLGGIGESAFQAVVPSFIDEFAPLEKRTLWMGLFGCSLSAGTALGFAYGSFLAQTIGWEFAFYIAAIIMTPLAYLVFACIPDVYNMPMAQMRDTAQSVGGLSLHPEPIKTSLLADTWGIVKSPMFITATLGWSACSFSISGMSTFGPAILIGLSVLPERICSTVFGAVVVVAGLIGAPFGGYLVDYQCRGRENDSAYRQYIVNRQMFGMSMCGVVLFFTSNLVINTSWALLLIWFVALGLLFATTSPVTVAVLQSVTKARRGFAMGLSTLLLHIFGDLPAPIVLGALKDMWAPHCGSSVINGRVTLNPECQLLDHDGLKWVLIFAYAWLGLAVVFWFASFALARRQLQHMSKLYIDFERSSTSIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WYY2</accession>
    <name>A0A6G0WYY2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_010240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000129">
        <property type="protein sequence ID" value="KAF0732708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WYY2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010280"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0732708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="34777" checksum="129DD86E42729E8E" modified="2020-08-12" version="1">MPPVASTLVLTVHGAALLDGAKPMKRIHPIVTASGKTFKGPACLDKTATPTWTDAEFTLDVAMKSHLYIRIHFIGTRNLFKRTIGHVDVNLGEKHLSKCGKYDLNLDLMGGRYKGQVKVTLVLRPATETHDGLEWARRQVAADTTTSSTSKQKKTCQTLLQCVPSWSSREALFKKACGPCFLALVAKQKACGTIDYLDNDTFPGKGSFVYKPTNRLLSDTVSTAGESDLSDDLEDHMSFNSLRASTLLDYTSPAAAAAGYLSIEEWMDARRSSMCVQSFTTKPTSTAIVSPQTPLLLHIMWLLPLVAIILDAILVCRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WZL3</accession>
    <name>A0A6G0WZL3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Golgin-84</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_010074</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000127">
        <property type="protein sequence ID" value="KAF0732969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WZL3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021712"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031985">
        <property type="term" value="C:Golgi cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000301">
        <property type="term" value="P:retrograde transport, vesicle recycling within Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019177">
        <property type="entry name" value="Golgin_subfamily_A_member_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13815:SF7">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13815">
        <property type="entry name" value="GOLGIN-84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="523"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="140"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="239"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="342"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="434"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0732969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="558" mass="62371" checksum="9C1F3DB8D6EE1CA2" modified="2020-08-12" version="1">MSWLSNSLQLAGELLESVDQKASVTFKPRGAEEKKKPKQEDGELKDFRVGSDQAAAFSVAWEIKPVSGGEYEFEMQSPSSAQMPSRSNSSLQLAGPHDADTFSEWSEVDNESNSGIVIDEMPLSSSSSTRSHLPPLPADMQTMRSETLRLRRENSKLRNDLSSVERQLSNSQEQLEVCQEELEALDKECMDKIASLEREIAQLKAEKAGDEGQFVEALAAKDTHALTLQTELSSFKKLLLDQSNEVDRLKNTLAELTSSKEVAWSNAASGEAHLQQRLTSVQTELKDALAQVALLKKENNETKQSMYARQCALEATNAELTNLVAKLEQNASKSSTPTDKALQQTQETLASTKKLLHEESRKSLLQSQEIARLTQDMTALQTLVLQKEQQHNAIVHKLQQQLDEKSKLTLRTATISTRTAAPSTAQPASNDAQMQAMTRRLLEKQEQLDALRSRYTTLEVRFNELKASKDDKNDAMETHMLPTTRPYSGRARLPQHKIPALEAADRIMLTIGRFLRAYPNARLAVLGYLILLHIWAFVILSFHTSHLNDEVHPKSKTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X107</accession>
    <name>A0A6G0X107_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_009733</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000122">
        <property type="protein sequence ID" value="KAF0733493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X107"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017076"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="3">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0733493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="32685" checksum="2DAF4E5328951737" modified="2020-08-12" version="1">MVEVSPLTLVGIFTIPGFLSFPIPSLIKRRKAQATLRKLLMQVIEDKLAAPVSETPKDLLDVILSHATTQEALSHTVTFMMAGHDTSSNTLGFIFCTLASHPQVNAAIREEYHKVISKYGSLKSWEAVSELKYTYAVIQETLRLNPVVFSTIQRISLENDRIPMADGSTVFLPKGTPIHTNMAALQRNPKYWKDPESFIPQRFIDGTPEWNADLALRSGKSHAFYYMPFSAGSKLCIGQRFAVTEMQVVVATLVSKYELTPTAKTDMRHCFSGLAVKPVLLEMKVRRHTAPCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X2C6</accession>
    <name>A0A6G0X2C6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_009220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000118">
        <property type="protein sequence ID" value="KAF0734048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X2C6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009572"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0734048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="21208" checksum="DACD0385833D1847" modified="2020-08-12" version="1">MVYKVTSLTPIQASLVAVGEASKDETVFIVHVVQGHRSWYTAHDFVEFEALADQIGHIVACDYAMCDTCHLARDIQLDCFHQKPWLPQTRKRRAVNRFTLVQDFLRALLVTTQGLLCDPDDVCSVTTAIRRFLQVDAAQPNHSSLTSLAQLKLFKQEALLMDAYPIYAPLKAGRSPSDRLSTASTTWID</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X2L8</accession>
    <name>A0A6G0X2L8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphomethylpyrimidine kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_008997</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000117">
        <property type="protein sequence ID" value="KAF0734128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X2L8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018879"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008902">
        <property type="term" value="F:hydroxymethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008972">
        <property type="term" value="F:phosphomethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01169">
        <property type="entry name" value="HMPP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19368">
        <property type="entry name" value="TenA_C_AtTH2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000003">
        <property type="entry name" value="Phosphomethylpyrimidine kinase ThiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004399">
        <property type="entry name" value="HMP/HMP-P_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004305">
        <property type="entry name" value="Thiaminase-2/PQQC"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00097">
        <property type="entry name" value="HMP-P_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858:SF17">
        <property type="entry name" value="HYDROXYMETHYLPYRIMIDINE_PHOSPHOMETHYLPYRIMIDINE KINASE THI20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858">
        <property type="entry name" value="PHOSPHOMETHYLPYRIMIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03070">
        <property type="entry name" value="TENA_THI-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiaminase-2/PQQC" evidence="5">
        <location>
            <begin position="18"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridoxamine kinase/Phosphomethylpyrimidine kinase" evidence="6">
        <location>
            <begin position="314"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0734128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="565" mass="61182" checksum="2B10C4566196653D" modified="2020-08-12" version="1">MKLSLHLWESAASTRFSCLYHAFVLGIGRGTLPLDAFQTFLLQDAFFLHGFLQAFAHAVTKAATTTDTITLVTLMQGVNDELKLHTSYMESWGIDPSIVESTDATPATQAYVDFLLTTAKSSQSISEILAAMVPCARLYAFLGHHFKAANPAPKYAKWIETYASREFETSAIAIESLLDATALRENMPTARLEALYHQAMTLELNFFEAYYPSHEMPLVLAPISIAVMDDRLLLRKGRGDAMEKDFDGSPLGFLLDQNPSATSYLVPETATEPERQACIAACALSQGTINAATESFQRGTPYAVPRVLCIAGSDSGGGAGIQADMKACTALGVFSTTALTAITVQDTNGVHGIHNIPLDILEAQIDCVLDDIGANVIKTGMLASKEIVECVVRATRNRHIPLVVDPVMVSTSGHRLLQDDALECLVQQLFPLALVITPNIPEASVLLDGRSIASVEDMKIAAADLHKMSHSQYVLVKGGHLDAENVVDVLFDGTTWQLFESPRIFTPNTHGTGCTLASSIAAIYAKVSDVPLAVGQAIRYVHSILHRSQHVQIGQGHHGPMLHWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X2T6</accession>
    <name>A0A6G0X2T6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial phosphate carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_009078</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000117">
        <property type="protein sequence ID" value="KAF0734215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X2T6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020299"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000138">
        <property type="entry name" value="Mitochondrial phosphate carrier protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="29"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="125"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="227"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0734215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="34071" checksum="22A90FB54DDC2BCF" modified="2020-08-12" version="1">MNPVATPTWNVRLTPPRLRPLDPHVHDASYYSLCMVGGILSCGSTRALVTPLDLVKCNIQVTPTKYTGLLQGLRVVLAEEGAAGLFKGWVPTTLGYSLHGMGKFGLYEIFKDGFAHAAGDKQKELRGAIYLAAAASAEFLADIALCPLEMTKVKMQTASRGTFPLKLQPALATMRATSPRFPFGSLVPLWCRQVPYTMTQFYCFEKAVEAFYTHVFTSPKESYPISTQLGVTFASGYAAGVVCSVISHPADSIVSLMSKAENGGKSVRTIARETGFARLATKGLGTRAAIVGTLVGLQWYIYDTFKAACGMGTTGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X4K9</accession>
    <name>A0A6G0X4K9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_008543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000103">
        <property type="protein sequence ID" value="KAF0734881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X4K9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020345"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18316">
        <property type="entry name" value="BTB_POZ_KCTD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499:SF136">
        <property type="entry name" value="GH08630P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499">
        <property type="entry name" value="POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="62"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0734881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="260" mass="28914" checksum="D06E48E9C3EE3F7F" modified="2020-08-12" version="1">MSSGNSSAQNVQPRTYSTQERCDEFERAASVVTVHVAALEKKMAQWKEIENQIQANIANSPNIITQDVGGTIFKTSKETLLRFEGSYFHALLGSGQWKPDTPNEAYFLDIDAAYFGRILRYLRTGELSFHGLCSLEREELKTTLEYLSITDPSESCRFWGPNLCALGLSEDLTTVTATHDGWRSVMGTLGAKSIQIVELGSRGEVYVGLARRDGFNPSNTHAYSCEYSICLKTGQLRRNGFVIVKSTVEFRSGDILTIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X5X0</accession>
    <name>A0A6G0X5X0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_008085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000098">
        <property type="protein sequence ID" value="KAF0735393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X5X0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013199"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="95"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="181"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0735393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="268" mass="29642" checksum="23B0B6619246E738" modified="2020-08-12" version="1">MASPECASDGLELDDSPPSDGLASYDLFVKWVLSSPTATVDEAAPAQWPSDFESLDTETTCPAAAAAPTSFASVTQAKWARATVESDHEALADELFTYERECQALADAIHALEAEKANDQQQVEALERLILERLQERDDTVTDQFTLEQQISILQQKAPPPGKALFAPPWPKLATLKFSAKEKLRRAIQSHEKQLAHEKLSLAEAKADVDMQSFTNRLLEKKCADLRRHLATLQMQEKQAKQALDQVQTTFHVMASKLHLVPHAASKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X649</accession>
    <name>A0A6G0X649_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_008042</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000096">
        <property type="protein sequence ID" value="KAF0735474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X649"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015594"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0735474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="31975" checksum="A9A99A10FE5C6196" modified="2020-08-12" version="1">MNTSVSVVRKETPFFLMHGWDPHTTITASLPTIRGDAEPEAYRWRLQVHQQQVYCHALNRDLVAAAIANRARRHNAQLPEDVDERIKVGDAVWLYIDQVKPGVKVKLAHRWHGPFRVLSRPNDYSSELESRVRHTGKVYRFHAIVHDSRLKPRRIYLERPVEVLLDVREIDFDEELALPDDSFLGGRPDRDDVLGSRPQVVAVRSVRYTEGIKEYEVQFRQGGPWIWEALVNIPPTELIYEFERVRLGFDRLAMMVQEELHPIEEEEVKGDDQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X749</accession>
    <name>A0A6G0X749_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">methionine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Methionyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ae201684_007764</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Met) + L-methionine + ATP = L-methionyl-tRNA(Met) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="1"/>
    <dbReference type="EMBL" id="VJMJ01000093">
        <property type="protein sequence ID" value="KAF0735758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X749"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014484"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02799">
        <property type="entry name" value="tRNA_bind_EMAP-II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.220.10:FF:000002">
        <property type="entry name" value="Methionine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000225">
        <property type="entry name" value="tyrosine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023457">
        <property type="entry name" value="Met-tRNA_synth_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008900">
        <property type="entry name" value="PRK12267.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326:SF2">
        <property type="entry name" value="METHIONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326">
        <property type="entry name" value="METHIONYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 12" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="14">
        <location>
            <begin position="550"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF0735758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="713" mass="80278" checksum="05632B3C908DA8C1" modified="2020-08-12" version="1">MEDIKTSLNALDVNDVKLHEEEKEKFYITTAIHYTNGTPHIGHAYENVTADVIARYHRTYGRDVFFLTGTDEHGQKIAQTAEAQGMTPIELCDKYSGIFQQLAKDLNMSNDGFIRTTSEKHKKFVQYIFDCADKNGDIYKGTYEGWYNVREETFVTENEAQSTDYKDPTSGLPLKKMQESSYFFRMSKYQERLITHFHEHPEFLQPETHRQVILKRLEEPLLDLSTSRTTFTHGIPLPNDPSHVMYVWFDALSNYMSAIDYPNGELAKYWPASVHIIGKDITWFHSVIWPCILMSAGFPLPKRVFAHGFVNARDGSKMSKSIGNVVDPYDMISKFGLESFRYFVVRGSKYGSDMPFSEEEFANIHNAELADALGNLIHRGLTLAVKYAGGKVPDVTATPCFDVEALRNATEEAFQNYALQEACFRFIEVVRATNGYLTTSAPWHVPDEHTRLVVVRTVLEAIYVFAHFMIPFMPTTAERIFGFLNAAPTTLPHLSPRFDNLVVGTPIKEVTKDDILFEKIKSDDEKAAEEQKKKAAAAPVVKKVKEELPLFASCEIRVGTIVKVWNHPDSDKLYCEEIDVGFDAPVQIASGLRQFYTLEEMQDRKVLVLLNIKAAKLAGFKSNGMVLCASNEAHDQVEFIEPPAGAANGERVFVPTESGDPVSEGQMKKQKVWEKMSVDLKTNELGQATYKGQVVLTSAGPVAAKSLKGAQIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X792</accession>
    <name>A0A6G0X792_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Agmatinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_007891</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="4">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family. Agmatinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000093">
        <property type="protein sequence ID" value="KAF0735889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X792"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003769"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033389">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via agmatine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11593">
        <property type="entry name" value="Agmatinase-like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="ARGINASE/AGMATINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358:SF26">
        <property type="entry name" value="GUANIDINO ACID HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR036979-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0735889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="35179" checksum="4C06BAA370464749" modified="2020-08-12" version="1">MFRRRWFSTGSSGVWNPRVKRAPVSSIPSFLPSVSSSVIVLGVQLDSNSSFLTGSASAPDVIRAAFHSDSANSFAENGVDLMHNPAITDMGNLLPSSMSTLSAAAHTIIHHEKRLLTLGGDHSITYPLVKGVRRALCVRGETRLNILHFDAHSDLYEYDVLNQGNRYSHASPFARILEEGLCSRIVQVGVRTHTKHTREQAATYGVETYEMKDIEDKWQELTRLSFDGPVYLSLDIDCLDPAFAPGVSHYEPGGLSTRQVLTLLQRFQGNLIAADLVELNPSRDVGKGTAPSITGEVPSGITAMVAAKLAKEILGRMCADESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X7H6</accession>
    <name>A0A6G0X7H6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_007585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000090">
        <property type="protein sequence ID" value="KAF0735992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X7H6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001126"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="298"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0735992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="392" mass="42289" checksum="12C25D1DC3E9FE23" modified="2020-08-12" version="1">MASMLEYTVHWESGNLGVWLQEDPSGSAVISKLVRPLPHHFTSLGDHVGSVGDLLISVGGRGVDKEYATAIDLLQNASLPIDLVFLNRRDETPAYTKNELAHTYEFEWTEHDGKLGLSFAKDPTTLLTILSSVNEDVMPPALKACHPRVGDIVLSIGAANVTEMKFHDVLAMLGHVEKPIRLSFEQVPVPSPTTVPPPTVPPPTTTSSTYDILYSGDSLGIVFTKGNARPVIKSTTGAHPEASVGDELISVNDQDTIALGFLETMEKIKHLDGKSSVLLRFHQPTPQVVDNAYDVLFSGGRLGLVLVGGPTPTSHPVLEKVTDASTARGLELAEKGDMLVSVDGINTATLGFDKTVEMIKHVHGRTVLLHFRREAKISTTNMVLSLVGALFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X7M2</accession>
    <name>A0A6G0X7M2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_007623</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000090">
        <property type="protein sequence ID" value="KAF0736035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X7M2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013724"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF73">
        <property type="entry name" value="PROTEIN PDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="2">
        <location>
            <begin position="71"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0736035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="423" mass="48752" checksum="89F8AC8C84C79D85" modified="2020-08-12" version="1">MPGSKTKHVRLELAQKMAIVEHYDLNPRATLEEVAAWTQLHFDLERRPSLPTISRILRNKVDEDRAKWMPHCKTYRSIASDTLVERILHWINLCEKHEVPIVTYRTIREKATQFSVLDNSGMNTSRSFSNGWIHRLLKRNGLSSRQTRGEAASVDKENVVQARNSMLELTRKYDPIDVYNMDETAFFYRKPPTRSISRNPMSGFKVSKKRMTVVVASNATGSDKIPLLFIGNAQKPRAFKRLTPQELNIDYSNTKKGWMTSQVFSDWVRHFNSRMASEDRRVILIVDNAPSHRVDEDLSNVTLRFLPPNTTSVLQPMDSGVIAAFKSHIRRIQTRYLVDECDKLFKSHEDSHSPLSVKEIEQIFAVNELTAINWATEAWANVTQTTIRNCWLHAGIVDEGYHDLLSRVKSLRVHHPTICEMSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X7U7</accession>
    <name>A0A6G0X7U7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_007634</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000090">
        <property type="protein sequence ID" value="KAF0736046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X7U7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002114"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0736046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="288" mass="32500" checksum="F9F25A2A3A5B719E" modified="2020-08-12" version="1">MGLLLSKKPRVNPALVFDWHGNRLTTQEDRRYAALHAIALRQYNRKDTEFIIKGLIDSVDNIHRIQPLMSQSSVGLDVAVHMTLPVPWEIVSRAVWQLYNGETQLHTTPSTQALERLDKHTVYEHCTESQNGEICHANSIRKLFSTNREHVIVLRSVLDDELSPRASKAAVEDLSLWLCTKPLDDSSCHFTFVVRFVVDTQSCLEGVSPKVLERVKTSFSRAKMEMALPAGGVFIAPQQIPQVLRAIPGYISLVDRSNRNRLALQTTLKALVRNYRKQPANALTNGIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X7Y4</accession>
    <name>A0A6G0X7Y4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hermes trasposase DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_007189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X7Y4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020564"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1070">
        <property type="entry name" value="Zinc finger, BED domain-containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018473">
        <property type="entry name" value="Hermes_transposase_DNA-db"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10683">
        <property type="entry name" value="DBD_Tnp_Hermes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hermes trasposase DNA-binding" evidence="1">
        <location>
            <begin position="57"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0736166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="139" mass="14785" checksum="D46F272129526146" modified="2020-08-12" version="1">MGVQQNFAACKSCKCVYVYKTGINATGTNTINKHVCDNMVPDAGKGQDDAIDGQFLRDRHAVFEAVAGKGLKAVIQDALDIGVASSARIDVDDLLAHPVSIRRNAESRTASGRAALTVVLKQHLENGVGVSCTLDLWTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X8G5</accession>
    <name>A0A6G0X8G5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">subtilisin</fullName>
            <ecNumber evidence="6">3.4.21.62</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_007264</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Hydrolysis of proteins with broad specificity for peptide bonds, and a preference for a large uncharged residue in P1. Hydrolyzes peptide amides.</text>
            <dbReference type="EC" id="3.4.21.62"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.62" evidence="6"/>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X8G5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019397"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF67">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026186851" description="subtilisin" evidence="8">
        <location>
            <begin position="16"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="9">
        <location>
            <begin position="162"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0736242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="485" mass="51755" checksum="4E62C469949DA0F5" modified="2020-08-12" version="1">MKTALVLALAAAVAADKVSVRLARYLEKKTESVSTETVLAKFKLDIPALQKGAASAANPHQYLYDTLKKTSDENLKTLAAIVDVKDVKPLWIAGAFAFPNATKATVDKLAASNSVIYLDLNAKDYKTPKVLKKTPSAREATAKNEWGIETIGAPEIWKYYNGTGAVVGSIDTGATNTHEAIKDNWRSDKGWFDPYLLYEEPYETDGHGSHTIGTMVGSHGIGVAPGAQWISCLGLFFGFGFTDGLLACAQFMLCPTKPDGTDPDCSKAPHVVNNSWGGDDGYDPWFEDAVAVWKAAGIIPVFANSNAGPACATVGEPGGYTSVIGVGAVGSFDSEPNLLAYFSSKGPETLNGPAYIKPDVSAPGFWTRSVDASGNNTYIEEGGTSMATPHVSGVVALLKSVDPKLSYDQIYHYLTSTTDQAPLNTTEPTVWTNIGRYRNESAPGGINCGGVKDTAWPNNRFGYGRVNVGTILRDGKLHDTRRSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X8Z7</accession>
    <name>A0A6G0X8Z7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_007493</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X8Z7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010884"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd02981">
        <property type="entry name" value="PDI_b_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929:SF240">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026335783" description="Thioredoxin domain-containing protein" evidence="2">
        <location>
            <begin position="16"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="9"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0736479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="501" mass="55793" checksum="5C8521DA87531FE9" modified="2020-08-12" version="1">MQLFLAFLAVAVAAAFEFPLPTFHEENHVLVLTDADFDDAILTHDTLLVNFCSKTSPFCGMVQPVFRDAAKRLVDIDPALRLATVDAGTNPKTPALYNLDKFPVFKLFRGHNDPRTVRDYSGDLSAHGIAEWMQEHSKPLVKVVTTVEEVEALRDKFSVVLLAHLDEIDGEMHQELELVAEHDRVSVVCATTDGSLHPGIDQVGGAVLFKAFDERLAIFDGVFTFDALSAFLRRHKFPMLSVLTAENGPSLMAPSNPSRLLLLTHLDEPTYPSIADAVTAAAFHSRQEIVHVVVPISETSRHILDHFGLDEDEDVPALVLMNAPKSQSFRFPLYGNNLIHNHKMVEPLLVEFEAKYLRGDLVPDAPPPEKLRPNLYTHVNAGAYEMGVLERDNVDALVFFFTPSCEICPALRAVFHQVAVVFMTVPTIHFGEVDGSVNKVAQPRRGNPLYPSIYFYPAKDRAHIVEYVGVVTVEAISDYLKVHARKFSLDGQIYGKRYDAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XB18</accession>
    <name>A0A6G0XB18_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Inward rectifier potassium channel C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ae201684_006525</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XB18"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000963"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005242">
        <property type="term" value="F:inward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034765">
        <property type="term" value="P:regulation of monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1400">
        <property type="entry name" value="G protein-activated inward rectifier potassium channel 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041647">
        <property type="entry name" value="IRK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016449">
        <property type="entry name" value="K_chnl_inward-rec_Kir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013518">
        <property type="entry name" value="K_chnl_inward-rec_Kir_cyto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040445">
        <property type="entry name" value="Kir_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767">
        <property type="entry name" value="INWARD RECTIFIER POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767:SF103">
        <property type="entry name" value="POTASSIUM CHANNEL INWARDLY RECTIFYING TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01007">
        <property type="entry name" value="IRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17655">
        <property type="entry name" value="IRK_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 11" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <keyword evidence="5 11" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel inwardly rectifying transmembrane" evidence="13">
        <location>
            <begin position="51"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Inward rectifier potassium channel C-terminal" evidence="14">
        <location>
            <begin position="185"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Inward rectifier potassium channel C-terminal" evidence="14">
        <location>
            <begin position="339"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF0737356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="416" mass="47154" checksum="01338E3464EBFC74" modified="2020-08-12" version="1">MRRSGHEVDEKSGAGVDYVDRSDALENPLLHGRQQTPRMIDRSGGMNHSLGTWNIRRLRAPHAWRVYLSAPFHTLVNMSLYKVLFCLTSVYLILIIIYALLYLTVDPSCNMAINTFPQSFIFSVSVLFTIGFGVGGNDIYFNSCGSAIFFITSQTIIGVFVDAIAFGIFYARFARGQSRAATIYVSAVACIQKIRGNLYFTFQVCEMRKHQLAEAHVRCYVILHKSPHFPHQVHQMQAYPMRLQQPDDDLNGWLILALPTTCVHRLDAWSPLTPPNLGELHNAATDYMYPEPPQRAVDVETGNRENRYRAEKEPLFERSQSPIEHVSGEDIERLLRYWSETHMEVVVVVEGVDASTSSTTQMRHSFKACDVLFNQQFVNCVFVDEKTGAAIIDFNRFDDTVPLDAKTLLGDHSFSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XBC5</accession>
    <name>A0A6G0XBC5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_006484</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XBC5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010612"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019185">
        <property type="term" value="C:snRNA-activating protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042796">
        <property type="term" value="P:snRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000010">
        <property type="entry name" value="Transcriptional activator Myb isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051575">
        <property type="entry name" value="Myb-like_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621:SF1">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb-like" evidence="7">
        <location>
            <begin position="92"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="8">
        <location>
            <begin position="98"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="8">
        <location>
            <begin position="144"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="7">
        <location>
            <begin position="144"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="7">
        <location>
            <begin position="195"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="8">
        <location>
            <begin position="199"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="23"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="247"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="575"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="91"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="296"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="318"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="401"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="419"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="429"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="443"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="475"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="575"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0737314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="605" mass="66983" checksum="7AE75090A44E0870" modified="2020-08-12" version="1">MNGADAGAPQLSAIGKALFETSLSVPDAAKKSGESSGTTVKRERTDSLKQMLPSPAAQRSKSKTTKPTPIVTTYLEPTPESGPNSLSSARGGDKSNPRRWSKAEDESLRLAVERSGERNWKAIADQVVGRNHTQCLQRWTKVLKPGLIKGHWTPEEDAKLRALVAEGRKNWGQVASHIPGRTSKQCRERWCNHLDPNINKGNYTREEDQLIIDMQAKLGNRWSVIAQQLTGRTEDAVKIRWKSLMRTKRTRDKEDAESNNSDDSAPTYQQPQQPPPHQPPAAATDKGNVAPKSRVAKQTTPKGNLQKSPAATVAPLRQNPTTSSSPRHSSFYIPNPTMLSRPTELPSEIPHRPTANPPHIYGPPRHEPLPRHPSLRDPPYIPPLPSSFTKQYPRMPPPPAGSSSSSYSMPYMLPPPLPSSSSSSGSYDQPPPPAPGGFPYPFPTSSSSSLPHQHYHQLPPSLHRLPSASREEWGTSHTPRSQLISNEGQVSEYELFHQQRLRLMVQERERAGPTLSPAASPGQAMLTKELEANSERQKRQAIMQSGWKNAVDVSEANSEELVKAPSEYEEERYDGFFESKETHLGEIDPSDDSDYRSRVALPPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XBK9</accession>
    <name>A0A6G0XBK9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_006661</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015579"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23011">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23011:SF28">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="80"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="244"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="862"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="703"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1233"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1368"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="708"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1371"/>
            <end position="1383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0737502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1546" mass="171841" checksum="3388906935711EC7" modified="2020-08-12" version="1">MTSVVVGAECGLSDITGKQANHPRKFSVLAQEATVAVTIRKDTFDRATAYMGAKTNSVFARQDVHDEGTALATYLSHFPFMEQLSTLNQKRVLDECRERKLRKLEPLLAPGASTFDMVIVLSGCLGSYRLERSVTTTTSLVGTAKTKQYGTQIGQVTSGECYGDLNIASGLAVDCREDGIATFTSSLIAEETTEVVLVDRRQVARLLTDQVPTTDFDVLVSKPPLERSWSQVGEIRQWLLKFFVFQQFPDRVITRLAETALGTALIPNKVIFNKSSDADAFYFVMAGAVTIQECPSNGTILPGDIFGIEEIQLKRKRQRIASATSDAFLVKFPKAVYWECIHCLASDIVWTPATRLLSMQKDSTLSTDEINDVAKLLRNLRVFAHVPLTLLVEIVPYMTVQTLSSGDVVCMEDTPCDTFVALLAGHVSCHSRDHTNEALGIFHDHAFVRVPSMQEETVFPSPLHAAAEKKFAALYGNVIHVLHARDVCRTGVFDTSTGMRRYHVTLVALTPSTTILTISDHNLTYVVERLVPWSTAKEDSLKAWIEQGERNAAASFGQDDMLELLKHFRFPFPWPLEKAALHLSCVKLQPGDVVVRAGEVLRHLVVVLKGHLVISVVQPRLNAAPIVHAMHANAFAKLLTSNFQSTSKTLASLRDARRLSTVLPSIAKMSRSTPWWQKRASATMAPPDTGRRRSSALRSLMENQPAEGTHDHGDPQHAHGHPDKSPTKPLVTFMAGDVWGAELVFARSWTSLHDVVAETPTEVLLIPRDVLVELRLEELAAATKKNEIQAKRMYDHNQLERVVMFVHRLAKAHWKRANNKVVEKMLSSSAAANAKPKFWRLLDQAASQRVKLIIKHLSGMELFQSMSDATISSIVASARYDTVEKGDVIYKAGDAPKRYHVVVSGAIGLYSAYPHLQDECLHVIHDSGGFGEFEILTKQLSRSLSAVAEDSTKLISFAAPSFLELWDAAKLDQMRAEVAFFQQLHWTRRLEMDKLAHIYHSAQALSYPKGGQIVQLHATLNHCFIIKQGSCFMGNIFDLEATNGLTDQVETMHVTTNLAHMCKGQTLWVLGRAEFSLTAAEPETIVCCISLDLLKQVLPKHFLARLERQIEQYAEYHAAQSNALKERAIAVLNARAQVYSSGGGGADSDMFLPPFDHGKHEMTLTDVVAATPLSLTHIQTNQELESAPLHEVRPPTTATTTSSLPLSAPSTMFGSFWRGRRLARLNKVKPVVDKPAARPSSRSEALAASIAPAPPRPLTPPSFFTTELPESHLVVAMGQFYLERYDVNSPFRTLRLEALPKTPTSATTAVAPAQTPPQVLLYHLDKDPPPTPDEGRRGNIATPGRKLVKRPTNVSNIVLDPSINHQANREKMRKVPFKQRKHSVLAAPKGTPPSEVHKTGKLAIRVVGSHNHRRQSHEHMVAVLHGSSLRLYLHEHDVNQRDMTQHEWNLTKSVQITEWPEDAQSPCDFLIHFDDNSIVWFTAVSMEEKAKWVAMLHRACHRDEHDASSTKLSMQQSRILPSQPRLQTTVMEVDLPEISYVVDLEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XBP0</accession>
    <name>A0A6G0XBP0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_006687</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XBP0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015551"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000009">
        <property type="entry name" value="Probable E3 ubiquitin-protein ligase HECTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF440">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NEDD-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="11">
        <location>
            <begin position="282"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="9">
        <location>
            <position position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0737531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="616" mass="69187" checksum="2292F56E7511547B" modified="2020-08-12" version="1">MVSQASVAPQFGLRRRQLQFNERDTTIYPTMIALVSFFILCKVVTMLRDKYCPRPASEAQASLLQYNFLQHLPGFTRGDVEQQLVHAERWKCDICQFENLVETLHCHLCGTAYDKPSQSPAMKDNAELSSSVALSIEPVALQPLTHRQLCARSRKNWTRTVVNDGMKWHFHCDQSSAFETQGCVIQARASQAQDDELENKSLTLEWLSIDDCDVQNTVVGEKLLLPVWCGLLQVSSLAFSAKYAWFLDQVSTIVLPYEAHHFRFKTRREHVVEEALAHLSQLDGDLGCATTRYEFKGEIAIDAGAVQREWYMLVAQSIMDESLGLFSIADHDTNGYYINPASQTKITEFRAVGRFLAQAILSGQVVPLQFSPVLFKAILGSPMTLLDVECMDPPMYRSLMHVLESEQVEDLALTFSAVERNGDSVVEVELIPNGANVLVTKASAHDYVTRMVRYLLFDRVQHQLAALLHGIYDILPPALLVPFDFKELELLVCGLSVIDVHDWKLNTIISSNLKDSPVYSWFWEVVESLNAVDQAKLLQFCTGSSRVPVQGFKGLTSYDGNICHFSISGKNYTPGMYPVAHACFNRLDLPLYPTKELVQAAIEVLLQAAPTGFTIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XC88</accession>
    <name>A0A6G0XC88_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_006730</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XC88"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020277"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050777">
        <property type="entry name" value="SET2_Histone-Lys_MeTrsfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22884">
        <property type="entry name" value="SET DOMAIN PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="8">
        <location>
            <begin position="82"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0737575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="217" mass="24722" checksum="21DD3F5D535ECFFA" modified="2020-08-12" version="1">MFRSCKIPAPPEVYEPFVNNTKNVVGMSFMKSKRRITAYNDKWSHNDCVKAANAHFECLPCSCDAGVNCQNSGVTRGLLVFPKTSVVESFHFDDALQLDEDVVKGQTIGEYVGEFILKAEYERRKQISAGTKDWYFLHVKRDLYLDGIEMGNLMRFSNHSCRPNAEIQLWHVNSEPRMFVVALKNIKKSTQVTLKYMDASWQMACACGHCNGSFELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XCY0</accession>
    <name>A0A6G0XCY0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_006008</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0738016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009894"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="244"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="520"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="818"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1130"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="275"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="371"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="423"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="524"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="555"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="843"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1146"/>
            <end position="1163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0738016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1289" mass="144688" checksum="83ADFC5DE8092FD1" modified="2020-08-12" version="1">MHRKRPTNVQLHPVAPPSTQVRGRPPAPVKRGSRLQLFKAKGRSKYDHSHDFDGNGTPEDDIMPFPRSRSVASSHQGEHDPLPLEYDDENHHQDDKSDSDVVPPTPKELVALKTIQGRVHHVMTAFDASMAQSPYGFDTSFYESSTTSAPSSVSWRVGEILMATHESLAMASGFNERLFTKACAGIFWRVLMSRDAQAVVDEWAHENTPAMRKMTRLFHKTVQMLQELQDSDRNNYYSHHALQAAQLAKPNSSSSGTVGPATGSGPPDEPTKATIQRLQNEKSILMSQLAETSNMYTTIAEVVKEREREVKRLQTVMEAQADQMMKLKTDLFLKHTDEAKHTTADTDKTVTLWKEKYAALSAAHQQGESRQRDLSKQNEDLAAQIRQLQDHQAHLERQLHETHLSSHGAKQETLPPPSNSVDVSSFEREIHILRSQLRDSQEKLTTVQREHEQELERHALDMQDAIERARQDAHAQLVVEAQHNTPMKFVDVAMQLGPPPTQEPPMPLQVELDDQIDPMSQETLQDDSKEEDDSGDEDGPSISDDEDDDHDAKHGQTSSHDGSTAWQRNPSAQELQIHRKLSGLIHQVFVEGSVGHALASVVPPSYLIDLTTISRRPSQGHDGVEPPLFVAQTSRRRSLRGSISTHDLTSLGRTGPLDGDNGADFNVDDLDHESQFSAEERIVRLKAAFEAEKTKLKQKFIDSMIGFRQDMIGQYEKKAMEIIKKHRAEVVRITEIAETKYGKLLDDKDKLLKEAKATIKALYKHLNDDARPLQPSEEVQTVKKILRTTFSLVAAKRVTKRLIETRRSKILQLRKDMESLAAKQSRSPSLPPTDEMTSDENEPTTAPSTEQTTNEQISNDQTITVQMTEEPPKKAVREEEVPPPPQVQVVKTPQLDISLPQPEPPPPEMRSLLPRTKMETPPPMEEAPIHVKVVARPSVRHASTQVNNNDWTPAQEAEMPQVDEELPHESLSKYVLRGTSLLDDSLSPSMLESASCFESTTGGPRRMETRFYYATQPPPPSMASPSRIETLLEDYATSLSTLRERINWNKWHCVLKCLGLKRMEDVLKVEMTASASADQALIRLRRRMTTKRAAFSKTHESLQRQQHQTWTHCLDALVCYNSLTPRTEPATTLHASSKEETRRPLATAPPAISTPTAAPTSPRTVKDGNLTAHAALFPTDLSTVSTEERQRYLRQVQACVGASTSRRPPMETSSVTKKTETTAEKDAVMVFKGVPSQSPFMRRKALESLERSMMHRRQLFAESSSGNARVIAAALDQTKQSITRQRFNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XD52</accession>
    <name>A0A6G0XD52_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_006055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0738064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XD52"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004726"/>
    <dbReference type="OrthoDB" id="10340837at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0738064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="125" mass="14838" checksum="CE28FA779EBC9DEF" modified="2020-08-12" version="1">MHDISSNPRCCHCKNRQRPKLPPKKTWKRMAHAEQVKLKQRQARAAIQSLEATKEALLTRRELKRSVRWNWFVIFSMEDGELLQRWAEEAAEWSCMSDDNRSHALLQLREHSEQAGHDVLWSFCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XDN2</accession>
    <name>A0A6G0XDN2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_005846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000077">
        <property type="protein sequence ID" value="KAF0738288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XDN2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012116"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0738288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="469" mass="52701" checksum="2D749C1D10DD98E1" modified="2020-08-12" version="1">MGSSISMLRADIKAHVQIALDYPNLLEPHLHGTSLDLLSSPSRVVVRFFLELCEEGEGITPKDRDNAEVLERIKENDFEVSTEVELVAENVVAVDILLGAVEKYNEMVPAPEFDTKKRYFARFRAPEPFPTLYDPVEEVDLPRCRVSLLRMALRCLRMITVIDDVKKQVRESSAVPAFNRAVDDNPLDLFIRKDVKAIFKSALQASLHAVTDVVDVYGGEQSLKCLEDSSLAVTVEVMTDFPDMEKVQLAAIKRLAVVLTSFSGTSSSVFQGIRTSDVDPAQLKAHVLSNQVISAVGVALATYPETRFDIYAHSCRLFTILVPPKQLKEDEEIGRPHDETLAKVIGQNGGVEAAIKLLKTCRGFYTTSHRVSPKNNPPQDDNRQPDKIRNDTPNQDDKEKLTDWTTPDLAQQALWALDVLSITEFNRIAMKREKLKYVLSEISLGSKLILPRRLRLLDWKNIGFESEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XEZ0</accession>
    <name>A0A6G0XEZ0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_005437</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000070">
        <property type="protein sequence ID" value="KAF0738826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XEZ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016807"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000808">
        <property type="entry name" value="Small GTP-binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="174"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0738826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="209" mass="23044" checksum="69EFBD9BD547E1B5" modified="2020-08-12" version="1">MDEVGIDRKLVILGCTDTGKTSLTIRYCHNSFATPTAATIGASFLQKRINIDRHKMTLQIWDTAGQERFRSMAPMYYRNAKAAILVFDVTKEDTFEKIKGWLSELRKHVDDDIVLAVVGNKCDLPTSFNFGLAEAFGREIGATVHRTSAQSGQGVTEMFETVSRALLKKHMDNERLAPAPSKSAPTPDPLVRLGESTTPPPKKNGGCCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XFK6</accession>
    <name>A0A6G0XFK6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_005214</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000067">
        <property type="protein sequence ID" value="KAF0739028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XFK6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013384"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000063">
        <property type="entry name" value="Multidrug resistance protein ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000610">
        <property type="entry name" value="Multidrug resistance-associated ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000997">
        <property type="entry name" value="Multidrug resistance-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="655"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="694"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="772"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="800"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="881"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="92"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="402"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="666"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="973"/>
            <end position="1207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0739028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1214" mass="135327" checksum="B75BDD328CD3ADE2" modified="2020-08-12" version="1">MRPPSYDSIPLKENDQQTRHPLETASFFSRVFYLWANPLMKLGNQRQLDFADLWPLQRENRCDVVSSEFSVKFRETNSILKAFLALYGWQTATIGVMQFFAMVCSLCGPMVLERVVSNIGVVDVWSLFGLVAALFGTNVLQAILQNQSDLLIEVLYVRLTAALQHLLYEKALVLNAKSRKGTGELTNLFTADMWQVLTLSFTANQVWIVPLQVISVMFLLWQVLGSAMLAGIGIIVLVLTLNRGMATTQKENWKVLMERRDARMKVINEVFNAIANVKMNAWEERYLDMIRELRDAELDSLRRHVWIFGGMSCMHHISLVVLISLSFAQYVFLLGQELTPTKVFTSLALFGMVKEPMMRLPQIIATWMLALVSYHRFADFLALEERDPNCVTSVVSCDDMSIEIRDGSFGWDAKKPFFQDLQLTIKRGEFVVVHGSVGEGKSTLCNILLGELDKYQGSVGVNGRIAYFAQQPWIQNLTVRDNILFGLPYDHAKYTKVIGACALEQDLMLFAAGDLTEIGSKGVNVSGGQKARISLARACYSDADIFILDSPLSAVDAIVQNELYTKCLLDLLRHKTILLVTHNPDIIASPYVDRTIEIKDGILIEKSNTDKKIFTPVASTDGVYAPSSSSAAKGALVVAEERVVGRVSKDIVKSYFEAFGGWPFIIALFSFQALGQVTQIASDLWLSYAISAETSYYLSVYSLIALAAALMNAGRTIMVLRAGIGAAKDLFDGMCRALFYAPLRFFDVTPIGRILNRFSGDMNQVDFPLPGALRYLTSLAFSFIFSLGTTVAVIRTFGLGLVPILWIYYSIASFYVMPAREIERLSKTSKSHMISHIAESIDGVAVIRAFGHVDRFKQVHHKNVDHRNETMFCNDLSGQWFALRIQLIGASMLFVITSSLVFSNLSPGMVGLVFNYSLQIMLQLQGLVQAWSSLETAMVAPERVAEYTNVEQEGMRVVPRSSDSSAWPQDGSITFQGVSYRYKPNDPLVLHDVCFEIQSGEKIGIVGRTGAGKSSLTMALFRINEIASGRIQIGGVSTATIGLKTLRESMAIIPQNPILFKGTLRSYLDPFDDYTDAELWNVVAKVQLTSRLSNEADKLLSVVQENGENFSVGERQMLCMARALLRQCRIVVMDEATAAIDHETDQTLQRVIRQEFATSTVVTIAHRLNTVLDSDRILVLDQGRLVQFDSPSALIQQGHGIFYELCQEGGYLDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XGM9</accession>
    <name>A0A6G0XGM9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative auto-transporter adhesin head GIN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_005058</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000065">
        <property type="protein sequence ID" value="KAF0739281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XGM9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017331"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.120">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021255">
        <property type="entry name" value="DUF2807"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39200:SF1">
        <property type="entry name" value="AUTO-TRANSPORTER ADHESIN HEAD GIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39200">
        <property type="entry name" value="HYPOTHETICAL EXPORTED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10988">
        <property type="entry name" value="DUF2807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026063831" description="Putative auto-transporter adhesin head GIN domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="619"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="Putative auto-transporter adhesin head GIN" evidence="4">
        <location>
            <begin position="438"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0739281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="657" mass="68469" checksum="4BC92BDD914CE5FE" modified="2020-08-12" version="1">MPRTLLASVLAVLLLPSSTVATGKCPGAQYEVSLLGSGTTYCLDARPCSGNYVQGQPVANSACPAQGQISVYGKHQIVAPTCCAIIHTDKNVIGCVFQSPQFQCVGPIPVPIATLPPSVVIDPKAKEVDIKPTAAPATVPVVIPTTTIVPTTTAAPTTTAAPTTTVAPTTTVAPTTTAAPTTTLAPTTTAAPTTTSAPVTSAPPVAAATAAVVVPATVPEKAIGGSTGSGKVVVVSNVTSNATTTAPPAVVPDKLVEQITYDASQSWILEDNVSSIVINAPGRVFVSNWTEWLSFKREAASEYQMAAIVISGTSLDKFNVLNSSDASVALIQMFNLTAADGVLTIEFDHHTSNEVVDGQILIEVFVRYPVVTSVIVRGQAETYVEGGVLRGENISLSTEDGDMVAFVNQTVANALSLHSTGAGSLQVSAHALTALDSLDAVTDSSGNIAYVVGNITVRNLTSVTADDGSVHIYCKKLNIKNLTSRVLGSGSIAFGRGTGVCTYHSVEISGSGSVYAGRVQCTDAMVKVAYSGRGDAVVQATNSILTDVRGPGNVLYYNTPPKIYPTYKKHFFLTTSYKANVTDTFVGPPPVHEAKEFHLGVPVGDSWLGSLTALDLDRIILYGCLIFVIIAAVVAGYKWYSVYKTQKQARGEYQPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XGN6</accession>
    <name>A0A6G0XGN6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribonuclease H</fullName>
            <ecNumber evidence="4">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_004975</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase H family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="4"/>
    <dbReference type="EMBL" id="VJMJ01000064">
        <property type="protein sequence ID" value="KAF0739406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XGN6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016854"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09280">
        <property type="entry name" value="RNase_HI_eukaryote_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000275">
        <property type="entry name" value="Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.970.10:FF:000001">
        <property type="entry name" value="Ribonuclease H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.970.10">
        <property type="entry name" value="Ribonuclease H1, N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017067">
        <property type="entry name" value="RNase_H1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011320">
        <property type="entry name" value="RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037056">
        <property type="entry name" value="RNase_H1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF26">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01693">
        <property type="entry name" value="Cauli_VI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036852">
        <property type="entry name" value="Ribonuclease_H1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="11">
        <location>
            <begin position="233"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="125"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0739406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="390" mass="43716" checksum="9CB2AC10DA01E832" modified="2020-08-12" version="1">MSFYAVAVGRKTGVFRSWDNGAKEQVSGYPSAKFKKFKTNEEAESFIRQNSLKRGREENYDANQPPTIKKRLNAVVMPPTPESYYLVLSGHSTGVFDSWSNVEGAILEFPNAMFRKFSSKAEAENHWRQHQASTDSAASSIPGATSAPPSSYEPLITKPTQKESCKQVKFYAVAKGRDGKSGIFTNWKEAEALVKDFYSAKFKSFLSLSEAEEFMAAHKSLVGAQPGDPDPQNSSTLVAFCDGSAIGNGKARCSAAFACVFPHNEAWNVSGKLPQFQATNNRAEYLAALEALKRANLEDPNIERPLYIFSDSMLLIRSMTEWLPTWQKNNWIKSDGEAVKNVDLLKQLTEARGNRRVIWRHVKAHTNKRDWKSIWNDKADQLARSTAFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XGZ2</accession>
    <name>A0A6G0XGZ2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_004725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000063">
        <property type="protein sequence ID" value="KAF0739543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XGZ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001963"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0739543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="103" mass="11393" checksum="CBB3A0819FC98467" modified="2020-08-12" version="1">MMPPDSSSNSTTTTTTTTTDESKDKNEATEATYHANSSDSNDEDDEIDEKLLSAKVWKLVRDMKRLKATTTARHDQLNATMEKMLATLTTLQAQVAPQPSTQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XH09</accession>
    <name>A0A6G0XH09_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Dynein-1, subspecies f</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">Ae201684_004985</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Force generating protein of eukaryotic cilia and flagella. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required for assembly of the I1 inner arm complex and its targeting to the appropriate axoneme location. Also required for phototaxis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">The I1 inner arm complex (also known as the f dynein complex) is a two-headed isoform composed of two heavy chains (1-alpha and 1-beta), three intermediate chains and three light chains. I1 occupies a specific position proximal to the first radial spoke and repeats every 96 nm along the length of the axoneme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
            <location evidence="1">Flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000064">
        <property type="protein sequence ID" value="KAF0739418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016863"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036156">
        <property type="term" value="C:inner dynein arm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060294">
        <property type="term" value="P:cilium movement involved in cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036159">
        <property type="term" value="P:inner dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000153">
        <property type="entry name" value="Dynein axonemal heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000002">
        <property type="entry name" value="Dynein axonemal heavy chain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002141">
        <property type="entry name" value="Dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000001">
        <property type="entry name" value="dynein heavy chain 17, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2620:FF:000002">
        <property type="entry name" value="Dynein heavy chain 2, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1120:FF:000001">
        <property type="entry name" value="dynein heavy chain 2, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000001">
        <property type="entry name" value="dynein heavy chain 2, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.20:FF:000008">
        <property type="entry name" value="dynein heavy chain 2, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000044">
        <property type="entry name" value="Dynein heavy chain 5, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000001">
        <property type="entry name" value="dynein heavy chain 7, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000049">
        <property type="entry name" value="Dynein, axonemal, heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056759">
        <property type="entry name" value="DYH2-5-8_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054354">
        <property type="entry name" value="DYNC2H1-like_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703:SF32">
        <property type="entry name" value="DYNEINS HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08385">
        <property type="entry name" value="DHC_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25007">
        <property type="entry name" value="DYH2-5-8_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22597">
        <property type="entry name" value="DYN_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="12" id="KW-0969">Cilium</keyword>
    <keyword evidence="11 19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0243">Dynein</keyword>
    <keyword evidence="9" id="KW-0282">Flagellum</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="13" id="KW-0505">Motor protein</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="21">
        <location>
            <begin position="1888"/>
            <end position="2025"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="21">
        <location>
            <begin position="2502"/>
            <end position="2648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="643"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="973"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="3108"/>
            <end position="3180"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="3324"/>
            <end position="3386"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="3636"/>
            <end position="3663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="657"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="978"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="991"/>
            <end position="1002"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00054075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00063032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00077719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAF0739418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="4535" mass="514344" checksum="795A6FEBB52324F5" modified="2020-08-12" version="1">[encoded data, 4535 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XH93</accession>
    <name>A0A6G0XH93_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_004853</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000063">
        <property type="protein sequence ID" value="KAF0739685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XH93"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009057"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033328">
        <property type="term" value="F:peroxisome membrane targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045046">
        <property type="term" value="P:protein import into peroxisome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.900">
        <property type="entry name" value="Pex19, mPTS binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006708">
        <property type="entry name" value="Pex19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038322">
        <property type="entry name" value="Pex19_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12774">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12774:SF2">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04614">
        <property type="entry name" value="Pex19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0739685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="288" mass="32284" checksum="0528ADFF85B7C823" modified="2020-08-12" version="1">MAGNDVDLDALLDDALDDFEDEEVDAVHEAKAKVDEAQSREMENLKESMAKFLEDAQNPEFQSVLEQAFREMNAESSNTNGESLESLLGSLKAKSDTPADVDVGVARTLQSMAKAAEDMEGMDTNKAEEMGEEMMQEMMKQFEQMGEKNDFQGLVDGMMQQLLSKDVMYDPMKQICEKYPEWLAEKEAHLSYEDYERYGKQYQYFQQILAVYDTEPENYARLSELMQEMQECGQPPSEIVKELAPGLQFDEEGMPIMPNMGPGAFPGMAGLPGAPMSGMPGQEQCSVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XHR5</accession>
    <name>A0A6G0XHR5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycoside hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_004567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000058">
        <property type="protein sequence ID" value="KAF0739865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XHR5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011860"/>
    <dbReference type="OrthoDB" id="64893at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="1, 4-beta cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Beta_cellobiohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036434">
        <property type="entry name" value="Beta_cellobiohydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34876">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34876:SF4">
        <property type="entry name" value="1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01341">
        <property type="entry name" value="Glyco_hydro_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00733">
        <property type="entry name" value="GLHYDRLASE6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51989">
        <property type="entry name" value="Glycosyl hydrolases family 6, cellulases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0739865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="379" mass="40578" checksum="FA4471E572957632" modified="2020-08-12" version="1">MAQLCPGLAPVNFAQAKKDYADIAYAIQAVEAKPLATWYTDRSDYVSEATATLSACAPRNGRLDTLPVFVVYGLPNKDCLGNYSTGGTYANQNAADYQLFVSKLASLVGTQDVLYVLEPDAVGLLAESTTQCGWSNNYLPNLVTAVKVLTSSNPAAKLYVDVGWWIFKEDARVQRLVDIMTTLSKAGKVQGIALNTANFRSNDELFNWCKVFVNATAGSNYTCVFDTARNYHGASPTGEWCNAKTAGIGVPPTSQTGLKNVDYFLWLKTPGQSDGLCLGQSSDALIGPTAGDFFYKGFCMMFDNGYFVDKGGLAKTNKFSLDGNSTSGVSGAVIGIILGSIIAVALAVLGIGLWMKKKKGTKRAKKNHHHASTVTALQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XIS7</accession>
    <name>A0A6G0XIS7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_004428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000054">
        <property type="protein sequence ID" value="KAF0740197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XIS7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016420"/>
    <dbReference type="OrthoDB" id="10304748at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026099498" evidence="1">
        <location>
            <begin position="16"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0740197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="102" mass="11287" checksum="F6B2F1227F0722B6" modified="2020-08-12" version="1">MKLAIVGLLAAMTLASPSFRKLAEKNYPLDIHADCLVDQERRLLDQMGAQYLHLDCAKRRVLLESASAQKAKVLPFAYGAPALLSHRQGIDETLSLHEPYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJP7</accession>
    <name>A0A6G0XJP7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_004090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000052">
        <property type="protein sequence ID" value="KAF0740351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJP7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012271"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0740351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="19995" checksum="5D94C2F5B2D3C1B7" modified="2020-08-12" version="1">MLSLYRLLQFLFALVAMLCFVGTYLPPHRDPSVSASALETSYAFNFAFLLSCVATIYSSVLFIFCERGEYEDFVPSRGYLEILADTTLCLLLLVATFLLSKDEAFTLCRHKAHIQCERLGWTFTFTMVESLLFGLPVVITLIQACFAMRGEREQPERAAKEVSLELPVLLTKPVATVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XK13</accession>
    <name>A0A6G0XK13_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_004060</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. RsmH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000051">
        <property type="protein sequence ID" value="KAF0740514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XK13"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003420"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071424">
        <property type="term" value="F:rRNA (cytosine-N4-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.170">
        <property type="entry name" value="Putative methyltransferase TM0872, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01007">
        <property type="entry name" value="16SrRNA_methyltr_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002903">
        <property type="entry name" value="RsmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023397">
        <property type="entry name" value="SAM-dep_MeTrfase_MraW_recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00006">
        <property type="entry name" value="16S rRNA (cytosine(1402)-N(4))-methyltransferase RsmH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11265:SF0">
        <property type="entry name" value="12S RRNA N4-METHYLCYTIDINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11265">
        <property type="entry name" value="S-ADENOSYL-METHYLTRANSFERASE MRAW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01795">
        <property type="entry name" value="Methyltransf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004486">
        <property type="entry name" value="MraW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81799">
        <property type="entry name" value="Putative methyltransferase TM0872, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0740514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="354" mass="40139" checksum="7C00D1388C500E31" modified="2020-08-12" version="1">MAWIPEERSGLDGEARGDTNNVTSIDKTELTHTNFMWVQLRRRAFHHVPVLPKETLELWAAHRNSPDKFYVDGTVGLGGHARLLLEQSSSSTQLLCIDRDPQMLEQAKRGLEAYAGRVHFELGSYKDIKKILPRAGFPAHVDGILVDLGVNSHHLDAGERGFSIYHDGPLDMRFDQSAAIPTAADLVNSLSEVELIKIFTRYGDEPLGKEYAKAIIRRREATAFERTDELKRCVEAIADKWKKKKQGSGKSIHPATRVFQALRIAVNHELDHLEMALPAFIDSLAVDGQLATIAFHSLEDRWIKRFFRDAIDEEDEPEFALVQRKAIQATDEQNQVNPRGRSAKLRAIRRIRHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XKE7</accession>
    <name>A0A6G0XKE7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Crinkler effector protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_003842</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Host cell</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000043">
        <property type="protein sequence ID" value="KAF0740801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XKE7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012605"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043657">
        <property type="term" value="C:host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045379">
        <property type="entry name" value="Crinkler_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20147">
        <property type="entry name" value="Crinkler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026080636" description="Crinkler effector protein N-terminal domain-containing protein" evidence="4">
        <location>
            <begin position="29"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Crinkler effector protein N-terminal" evidence="5">
        <location>
            <begin position="25"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0740801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="440" mass="50341" checksum="783C5D9664AE0BCE" modified="2020-08-12" version="1">MFTISCTFPKFTISATSVILKMILLCCADVREERCFIMEIGEEENIYFLKKRVKKELGYRGPAMKLDLYLALKNDKWLDYESVVNGELTETIKELTQKDNRITRDGTIRTFFIGEKKPAIAEGQVHVLVVAPEDDAAGSVLGKREFLEAVESVMKKQKTDRTSWAISKLSMEKIDQLLFKIRRKRFPATDDLSMERDHPEFEWIDGKSESNREHVDLYKKYITTVLGNTTDLSIETGLTLDVSVGKPQFLLRGKADLCITPDGCLGRNEIVMVIELKSGCREETLSPANFAQTLGYFLAANTLFDCDDRPPPIGLLTNLKDAWCYFWVNAKKEISYAFKKKNGELLDRKTALYYLRKHCNYVNSCLQDEDVQSSNVSHATPDPHVVFGMIPAGRLEKYIVEYEDNMADVLETDEEIRLYEMSKRLRNTTAFVVPPPLMYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XKK0</accession>
    <name>A0A6G0XKK0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Complex 1 LYR protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_003755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000042">
        <property type="protein sequence ID" value="KAF0740865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XKK0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000248"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="2">
        <location>
            <begin position="4"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0740865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="123" mass="14344" checksum="E0E5C53A49F00B81" modified="2020-08-12" version="1">MEKTVRTAYKKLIKLAKSLPAEQRPETLDKIRHEFRSNAGISTPAELDQLVMKAQSKISYLKIVSPKRTPQSSPQRFVYKDGQRLDSDGMDSESNAKYKTTDFDAMMKRHVKLIRRQHFMDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XL61</accession>
    <name>A0A6G0XL61_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_003721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000041">
        <property type="protein sequence ID" value="KAF0741158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XL61"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004227"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="44"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0741158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="220" mass="24901" checksum="88CB9A36D5AA1C7A" modified="2020-08-12" version="1">MEVAANHGEIPPLAQTTTQRHIMLAKKDPTMSTKSSSSTVGEDNLVRTGIMYKKGSKTGFFSRANWKPRFFTLTWDKLSYYLFEGGELKGEVDLRQCKLDDIQVMPADSKKTGHSASSIWRISINTPSRRLLVAAASEFEMNEWVEDLREVVARHEHPDDSPVDLIRPSAILRPTLMDAMELLAVSNKRRISLVPARTYLRRKPRPTLEQDESDFVSPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XM52</accession>
    <name>A0A6G0XM52_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DRBM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_003222</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000036">
        <property type="protein sequence ID" value="KAF0741539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XM52"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000379"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070877">
        <property type="term" value="C:microprocessor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070878">
        <property type="term" value="F:primary miRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031053">
        <property type="term" value="P:primary miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00048">
        <property type="entry name" value="DSRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040375">
        <property type="entry name" value="DGCR8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13482:SF3">
        <property type="entry name" value="MICROPROCESSOR COMPLEX SUBUNIT DGCR8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13482">
        <property type="entry name" value="MICRORNA PROCESSOR COMPLEX SUBUNIT DGCR8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="WW" evidence="3">
        <location>
            <begin position="11"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="4">
        <location>
            <begin position="146"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="70"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="70"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0741539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="263" mass="29086" checksum="7EBB7BC67365C9DC" modified="2020-08-12" version="1">MSDVMSSDSLQNMDDGWVRVPHNSGRYCYFHSPSGYITWSEPYKLALEDANEADWERLVQTHAPLGCTPSHASAMHVASSAEASHQVQRSNRVESQTSASENGEVQAESAPPGEYPALTEDQLAFRSMAICDERVLPMCVAMSESTPISLLNEFVVSRELSPLMYTETSTGTLTHPQFKCVVTSGSLSAEGFASTKKDARHRAAQALLELLNPSVATYFELLEIKKVEADIRQTVKHAESLRKKSSKLKSRVKRRIAHVHSCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XM61</accession>
    <name>A0A6G0XM61_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Acetyl-coenzyme A transporter 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_003160</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000036">
        <property type="protein sequence ID" value="KAF0741475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XM61"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004514"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008521">
        <property type="term" value="F:acetyl-CoA transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035348">
        <property type="term" value="P:acetyl-CoA transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024371">
        <property type="entry name" value="AcetylCoA_trans_1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004752">
        <property type="entry name" value="AmpG_permease/AT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778:SF9">
        <property type="entry name" value="ACETYL-COENZYME A TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 33 ACETYL-COA TRANSPORTER -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13000">
        <property type="entry name" value="Acatn"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="457"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0741475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="498" mass="55409" checksum="0D1C74EAD26B2D4D" modified="2020-08-12" version="1">MAAEKAANPSTKTEPAKEDEPNNMLSIAVLMVLYTLQGIPMGLSSSVPFLLQGKVGYAEQATFSLVSWPFSLKLVWAPIVDSIYSESFGRRKSWLIPVQLVCSAMMIFGGPFVGILLDMEEPDVHMLTLFFFALYFLMATQDIAVDGWALTMLSAKNVEYASTCNSIGQMLGYFIAYVGFLALNDPSTCNAYFRAVPEDSGIVTLASFMTFWGYVFFVTTLIMWFFKSEKNDPDHNLTIGETYHQMWSVVQLPSVLALTAIQLTCKVAFSATDAVFSLKLVEYGVHKEKLALLSPILVPLGLILPVVITSRINKDAPMQLFLYAIPLRLMVGVIYAFVVYYTPTIMSHTEDVHYIYYCFLLLAGAFHETTSMMMYVPQMAFFAKVSDPTIGGTYMTFLNTISNLGSKWPNSLSLALVDTLSYKVCSTDATNLCLDHDAKVACEAINGGHCTILVDGFFVETAICTVVGIVWLVFMYRRVDALQKLPMAAWRIRKDKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XN36</accession>
    <name>A0A6G0XN36_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MATE efflux family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_003376</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000036">
        <property type="protein sequence ID" value="KAF0741711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XN36"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020870"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="441"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0741711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="481" mass="51692" checksum="BC765A129D51BD75" modified="2020-08-12" version="1">MEASSYEPLACEDAKTPGLESDERLAPLSIIEELLHHMRLAGPLIFTHLMDYLPGMTNIVLVAQFQGPEVDANVTAVALSTMFLNLTSISLGMGLCSAVGILSAQAYGAGNMKLFNAYIHAAGLGMLMTMLPVAWLNWKAESILTYLGHDAAIAGKAASFTRISTIGLPFFFSFEIVRKLLQAHSTVDAMAVISLASNVIHVGAGYYLTHETSCGFTGPAIGRVVANMSLLVFVAVYFHFKPTYKAWDLHWTPRLAATHLAEFFHFGMPGAIILWVEFGSFEILSMLATRLSNPREQTRVTTVLSHLLSVMYMIYFGISTASMVRVGNMIGANRPHAAKTIMRISFGLVTICLACTITTIASLRETIAGAFFADSGVIHSAKKLLLYILPLHALSSYNSNAQGVLRGMGQPGVAAFINAACICCIGLPLSAMLGIQQDQGLSGLWLGFTVGSAASFVLFSVVLASADWHKQAADAAKARRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XNC5</accession>
    <name>A0A6G0XNC5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_002922</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000032">
        <property type="protein sequence ID" value="KAF0741981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XNC5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021614"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050367">
        <property type="entry name" value="APC_superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42770">
        <property type="entry name" value="AMINO ACID TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42770:SF7">
        <property type="entry name" value="MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="6">
        <location>
            <begin position="41"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0741981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="347" mass="37818" checksum="48ED6E838A2D71C8" modified="2020-08-12" version="1">MSTGVDVGASRAHENYRIRSADIWAFGVTISAQSLSWNNGFTAGFGSFLIVALLVGAAYVSLILCLGEIMSALPFAGGAYGLARCTLGFTAGFLVAAFEIVEYIAYTATAMTSFTHTLAYVAPATNLYQPIIWFLVYIICLSIHIYGAAAFWRLNYFFAAASLLPTITWIVGSIPYLDYKKQLQLDVMFIDGFSGFMRAFPCATWLFVGLEALNTVGDEIKDPRIIVPKGQRFAIATVFCTGITLIIISGGLPPGIRAWPDVMNTWTSGFSLIFQTTDVYSTYPSVLGPIGTLYGFIFAYSKLLTSVGSSNLVSKHFQTRFFKNETPAISLVMGAVVAYFLCSMVYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XNI0</accession>
    <name>A0A6G0XNI0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ammonium transporter AmtB-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_003001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000034">
        <property type="protein sequence ID" value="KAF0741809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XNI0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016228"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097272">
        <property type="term" value="P:ammonium homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11730">
        <property type="entry name" value="AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11730:SF6">
        <property type="entry name" value="AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="316"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="9">
        <location>
            <begin position="44"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0741809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="484" mass="51346" checksum="0C9937DBA84EDDC2" modified="2020-08-12" version="1">MAVTANSTLSITIDGQVTEIRWEALVAQLSAAQNVAPAETLDLFWFIFGGVIVFMMMLGLALLEIGCVGQKNTKHIMFRILGDCCITGLTYYALGYSFAFMEGNGFIGHHGFFMSGDSFQRPSATKLFRGHHYADFFFQWAVACVAINIASGALAERVSLAAYFCYTFFSSLFIFPVLAHWIWSETGWASAFNLDKLLFGVGAMDFAGTGALHMFAGLSALVGCIIIGPRVGRFGPDAVPLPKQSVLFQFMGVMLLWFGWYGFNCVSTLSLAGTKADIMAKVAVNLTLSACTGGISTVLLTFWAHKVWDIEAGNNGILAGCVAVTGCCCVIEPAPAIALGFLGSVVYLSVAKLVALAQIDDAVDAVPVHFGCGLLGTIAPGFFASPTGAKMFYNSDSCGVLYGCSLSGKQLGAQLVYALAVFGFVVFCVGAIFLVLKKFGLARVSAEAEAMGLDAFEHGGSAYTNDADQGDSYMETKSPLGVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XNT3</accession>
    <name>A0A6G0XNT3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_003105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000034">
        <property type="protein sequence ID" value="KAF0741919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XNT3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018593"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0741919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="92" mass="10086" checksum="F6D0872108595276" modified="2020-08-12" version="1">MEQSFNNFSSLDMSSIQHVRALSLFDGSSSSGIYVLAISAGVVAVLLFLYGAYKAKRARELELQNRESTADTVIHLEIETPKSCAYSRSHGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XPX2</accession>
    <name>A0A6G0XPX2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_002593</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="VJMJ01000027">
        <property type="protein sequence ID" value="KAF0742498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XPX2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012300"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF9">
        <property type="entry name" value="CHITIN SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04212">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00745">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="629"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="664"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="696"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="741"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="766"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="854"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="880"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="domain" description="MIT" evidence="12">
        <location>
            <begin position="145"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0742498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="958" mass="107088" checksum="9EE9EB6B196922F3" modified="2020-08-12" version="1">MSKNVDFEARLRALRESNNAQAALDNTPQPPPPTSNTGTAQPPRTLFAQESLEFGGTYVNASPMGSESETSFQVPMWRDTKDTTNSYLDELLENGGDEPIPPTSALLNMAKNVQERQQSFREANLLRRKSSVLPLPSTVEELLDGGVSYEGAFRLVQLAVQMEADGNPSAAIQLYIDAGKMLVEVGKRELDPLLQKGIRQKAHEMLQRAEELDKWMNDVAEEARRAALPPALRIARTNVPLVEQSWKGRTPPHNDADEFKSMRYTAVATKDPIHFSDDKYVLRVHQLQRNIKVFITVTMYNEHGDELKGTLTGLAKGLRYMCKEYGVDYWKHVAVAVVSDGRTKASPSCLEYLNGLGSFDEEIMTVTSLGVDTLMHLFESTVQLPENPTFESFYPPLQLIYALKEHNGGKLNSHLWFFNAFSEQLNPTYTVLVDVGTIPAESSVYRLIRSMERNYQIGGVAGEIAVDKPNFFNPVIASQHFEYKISNIMDKSLESVFGFISVLPGAFSAYRYEAIRAVKGVGPLPEYFKSLTSTTKELGPFQGNMYLAEDRILCFELLAREGRQWTMHYVKDAIARTDVPETLVDLIKQRRRWLNGSFFAGLFAIGHFGRVWSKSAHTLPRKLVFSFQFFYLALQNLLSWFLISNLFLTFYFVLTLAMYENAEFFLQVILSVYLAIVGGLIIFALGNKPEPRTANFYFFCCLFMGLVMTVVTGLSFYGLVAKGVTATDPRQGLKTCSVSKFELTGGVVSSLGLIFISAFLHGEFSILLSFVQYYFMLPTFVNILGIYAYSNLHDLSWGTKGLESGGGHGPAKAAGGNVKDAVAQQKKLEAARAAAAKEKEDVDNSFRAFRSTLLLSWLVSNGVWMYVIMATVASSCYLKGLSYTVAFFNIIRFLGAVVFLVLRICRRFGIRGCIQGATHDTYDRQLPPEWQAHRTGQAARFRAQDGGQSPVNGHYNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XQH7</accession>
    <name>A0A6G0XQH7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_002500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000026">
        <property type="protein sequence ID" value="KAF0742600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XQH7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015664"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF463">
        <property type="entry name" value="REVERSE TRANSCRIPTASE TY1_COPIA-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0742600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="450" mass="50214" checksum="D7B867C631DEE0AA" modified="2020-08-12" version="1">MTTLRCCMALTATKKLAVLQADADTAFVQAPIDKDVLIYVDQPPGHSDGTNRKMLLIKALYGLKQAALAWFEHCRKIVVGLGFRPSDYDPCLYLRQHGEELEMVATYVDDFLVFARTTVKANSILDELETKMKLKRQGEMSFFLGIKIEYDQNDGKITLTQEAHARKILARFGMTTCHGYTTPEVDDREDLWHDSSQPSTDQETYRSMVGSLMYLMTCTRPDISHAVQRLSRHLHDPRVPHAIGAKRVLRYVKHTIGTGLIFRSPDANLVGYCDASWATRPDRRSTTGFACFVGGGIVSWKSARQRVVALSTCGAEYVALAELAKEVVWLRGLLEDMNMKQEQATLTWCDNKAAISTAENVGVASRSKHIQANVLDLRHVGTADQLADVLTKVSTRAAIDKFKTVAMHPENKNGMKQLDEISQSEDDSYQVKSQTAPSLRSTSRTNTGEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XR33</accession>
    <name>A0A6G0XR33_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_002275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000023">
        <property type="protein sequence ID" value="KAF0742879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XR33"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012746"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052050">
        <property type="entry name" value="SecEffector_AnkRepeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586:SF3">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0742879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="339" mass="38474" checksum="2E584FE2EF92322D" modified="2020-08-12" version="1">MAEATVDASPALELNGLPDTTREIVESLRRKPTQQWILRPQFLPTVPATLEGILLQIPKSVLQLDHESHARAFPLLDEEQAVLVHLTYGHFAKEFAAWKTAQGMHGVQQALELYPTLRPAFFYCAVIAGDLELMHIILNSDIAGAFELSGESKEDYLNHVHVFAFRLAVIYNQVEAVEYLLDHPRWIEVTVADFLCLPMQLAMEAAASKGKLGIVQILHRHYSVEELEKDNSPLAMDVAVAYGQLSVVKFLHENGFHGCSDSAVRLASEKKFTDVVEYVELHNLVATSFREDQLFLDSAPEPIPLQVFFGDFFYVDIELTEEKFQQWMEDHKDDQFYPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XSJ7</accession>
    <name>A0A6G0XSJ7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_001734</name>
        <name evidence="3" type="ORF">Ae201684_001735</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000013">
        <property type="protein sequence ID" value="KAF0743590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VJMJ01000013">
        <property type="protein sequence ID" value="KAF0743591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XSJ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019735"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036174215" description="WSC domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0743590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0743591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="188" mass="20496" checksum="0F9EF8C0CE495E12" modified="2020-08-12" version="1">MKFTALLAASLVVLSVLAEEYDWQTLVGGNAIAGRKSLASFNNTEVLQDCRKKCEGVDGTIGISHSGYFKSCECLAQVYTYNPVWSKAVDLKATALLNAANCVYSAQGDVKKYDVVDFQGTYDDCLTKCPREGNSFVWTRGPLGDMLRPTGEDGHCYCKQVPSTFDTKTLVADASNALVFCQFNPPQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XTP5</accession>
    <name>A0A6G0XTP5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_001457</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XTP5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002696"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="411"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="789"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="847"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="881"/>
            <end position="893"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0743811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="893" mass="100867" checksum="F72841F4CA09209F" modified="2020-08-12" version="1">MADSKEPKSPVRPFSHDMHQDVARVDGHVTETAAEVKETAREVKTDFSHIKVDITRSPRSGGESPTMKGKFLGKMETLKKLSPTKEDMVAGVNKLKNLWRYRSSTASDGDGDMDDGYSSSEDEEEGWEAVLNKPIEEILANHSQRKWKDAPDYLLRNLSIHTLVQLPITHRRKLYLIVTGPCLALLVTIANWVLAASIFFMYFLLVGFGSAVYAWAVLVGILPRPELRTYGAAFKLEYEALKLFLRLEWEACLDYRVRQPRIDELVSTDDKEHKKRILHQLVMTVLDNIRSDVDGSKRFKEVTGTISLGSVVVGATLYTLFVFFTFVKTQMEFQEMNTRFFDGLAIILPFLLAEELAVFLARVTLVIKWFSVFLHDNTVVQMFVDKEPDEASKSAFINDARTMCKRIGVGAWDMTGIASAMTAVWTIFFLYQSYYVDCKSSGIDPGPAGLADTMFWSMVLYSIVIIALCYLPFTQWFAGNSESDEKYLAMLKSCQTFMVMNRLSAVQHEISVAIRKEYARVRGVPVGQHVSHEEKRMLRTFRAGILKTFDKADFVSFFLYTICLTLVDFDSPDGENEFYRHHVKQLRLRGSYLHCGKLEIPIDKLQKVEIELFAAQSGVDPWEEDGDKKPKEKPQGAIVPSLFDFEVLDAPVGDSFVDKEVYELSQLLENPSVRDFAVYRNPYVDKVVLGLELKMMERNDKRKGITTNVLASVYLLAMTINGKYEIGHGPIFLRGAALEKKTLKMEGVDVIFEKVSGKILPRYVRRCCLATSHEKRLFDQADEYLKGLIPHGAPGGGNTESKHLVRTGSASHLSPPEYRTASASTFSPVLYRTGSGHLKADMTPQREPNESMQRRPSVRDAQRQGSDSALEPVHQRPSVRDLSSWSALPSNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XV20</accession>
    <name>A0A6G0XV20_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_000986</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XV20"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019674"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="647"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="174"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="266"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="674"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="824"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="739"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="174"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="189"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="286"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="311"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="696"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="832"/>
            <end position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0744510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="843" mass="92719" checksum="95E87C59B96569DB" modified="2020-08-12" version="1">MGASDLPPGPPLANTTPLQPRPRAAPPDPAVPPHLLCARTAARRQSQRLRQRIQSKVVSPTAPLLAFDTNATVPTTPTTTSQSLGNHTDLLINVHEPPPPSLTAKADKPLPACQALHPPVPPSPTTPPDSWLDEPYLQANSPARPFREHQHQRLLPLFQRTLPILFPLFTSPSRTLSASPTSHQPILQSDTSMPPTSTPPLAQAPPEQNQAAAASTPQPAASLPSLTEPRTIISMESYQKCKRDEDLNSTTAKRVAPTIALVAAPSTLAHAPTDTRTMADTHQDTDMQATEPQGSSQNQQPAGASPSPKRPGLEEIRDECHPPVPYPNDSLFWEAEDELFPVLTDEEINNIETAFAQSTNMLVFHLNPDDAARCNIVNFREKITNDCKYFFNITFPTPLSGGTTTASTLMGTPIERHIEAWSAAKRGYMLLPKVMILVSYQHAAHIDPPQSLNQLEYSNTDYMSPNELRKAFHALGAPDYIHWMHQPSVRQTLQIPSDVPNQALTELIYANYHALRRTQSTHPDIPNSLQLRPLSELHWDQPTQTFFNPILPANSHLRDTKLRLSLIPPSIRTADIALVLAEHVFDNTDVDITGTVATLTFYNSEIRDIAWQTWRTDPLVVRDYPLAVSALTGPLQRPLQSSTFLTCRDCGRLGHIASECTVFQELDDHGRTLRSQAATTPNMPYDPRRDTKRSQARSGRSRSTPSANQKGRSASHGPTQVVATKPTGPVGNTLAFSDVRRLQERFLRVEAETKRHSEELAKVKAENMAQKAQIEEQAAQLATHAARHASTQQVLEEQARVQAQAAEDRQAMKANIAQAIALLTQDASSSAPPAPTPHTPQQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XVU2</accession>
    <name>A0A6G0XVU2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="3">PPIase</shortName>
            <ecNumber evidence="3">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_001078</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XVU2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002517"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044665">
        <property type="entry name" value="E_coli_cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43246">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE CYP38, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0697">Rotamase</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026380322" description="Peptidyl-prolyl cis-trans isomerase" evidence="3">
        <location>
            <begin position="19"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="4">
        <location>
            <begin position="33"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0744612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="195" mass="21833" checksum="0C437A5826820255" modified="2020-08-12" version="1">MRRLAMVSVSTLATAALAASGGDHAAVITVHYETQAGNITFDIHEEWSPLGAKRFLELIQDGFYDNAAFFRYVPDFVVQWGLAADPKRNDYSTIVDDKIGVVSNTLGTISFATSGRNSRTTQVFVNLKNNSRLDSMGFTPFGIVTEGMDVLLDKVYSGYREEPDQRMLRMRGEAYLERSFPKITHITKSWVRFGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XWI3</accession>
    <name>A0A6G0XWI3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_000706</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000005">
        <property type="protein sequence ID" value="KAF0744873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XWI3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012084"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019185">
        <property type="term" value="C:snRNA-activating protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042796">
        <property type="term" value="P:snRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000016">
        <property type="entry name" value="Transcriptional activator Myb isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051575">
        <property type="entry name" value="Myb-like_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621:SF1">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="294"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="7">
        <location>
            <begin position="300"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="6">
        <location>
            <begin position="301"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="346"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="7">
        <location>
            <begin position="350"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="401"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="7">
        <location>
            <begin position="405"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0744873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="469" mass="53116" checksum="B4AC543598759034" modified="2020-08-12" version="1">MERVRFQLQSLVKGNASASEPHAVKTVGTIYGIDLRTKFTIAVLGPSGVGKSAVINKITNALRRDSFFAPLNSREREYYPRVYAWHALCLIDIPEVPPRTEVSEYFQAYHLSTFDLLVFVGQDGRLTTVDLDLIDISIQHQCSAVFVNTKIDISCANFRNDEDVDGNVPEAALFEEIKTLLVSSPPLTQLRLPLFFVNASSRQRTGFDYENERFLEHVLGQLKSIADEKSDVIPSLMALRSYVGPSSQTPSLPNLPSIKMMLLPPLRQHDSNPADSVPLAPKSQIQQVRNGSDEIKANPGKWTAEEDERLRAAVERHGPRNWKAIAKMVQNRNHAQCLQRWRKVLLPGLRRGNWSHEEDVLLQSQIQLHGGEAKLNWAAVAAGVPGRTAKHCQERWRNYLNPNIKRGPFDQEERDLLTQLYAQWGNQWTRISESIPGRCPVDCKTNWFIMHPEHKLNQRPGPGRPKLYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XX31</accession>
    <name>A0A6G0XX31_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_000623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000003">
        <property type="protein sequence ID" value="KAF0745046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XX31"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001746"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="366"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0745046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="460" mass="50020" checksum="B423805BB4327590" modified="2020-08-12" version="1">MEPQLDAEQVRKAVVALKQFIQKKKSQNSKQALVEDNQVIQIIFTRNTVPAKESLKPVPIALPNNIRGDGEVCLFVKDSDKDRIKAHLKNDPIPGLTKVMPVKKLKKNFSQFKDKRELKAAYDLFLADDRILPYLKSLLGKTFFDAKKQPTTVNVTGKKNISDHIRRVLAGTEMFVSPGPCFNVKIAHDGMDTEKIIENIIEGTKNIVEHVPKKWKNIKSINIKTSDSVALPIYNSLPNSSKLPTDIKKRKVEEASSAEEQPAKKAKTKEKKVKVVAKPASTKAAEKADKVEKKVAPAKKEGADAKKPVAPKKEQNAAKKATPAAKESTTVKKEKSAPAKAAAAVKKEKTTPTKESTSSKKEATKKAASPATKESTPSKKEATKKAASPATKESTPSKKEATKKSASPAAKESTPSKSEKSPAKKAASPKEKAAVKKEKTTSTKKETPAKSPAKKGKKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XYV2</accession>
    <name>A0A6G0XYV2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_000124</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000001">
        <property type="protein sequence ID" value="KAF0745673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XYV2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011364"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39290">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39290:SF6">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="4">
        <location>
            <begin position="579"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0745673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="675" mass="75319" checksum="917639092894CD4F" modified="2020-08-12" version="1">MAPPHNRTKKRKNALVGLGANEIAFIEDEIAAVAMEYGLEIDDDVAKSIQSRQAAAASTKKHKKGAVATPTMAKPSLDSKALQALLPKQCTIGPCKSPGCNCRGYVHDKKNGEDCHKCDHGKFLHSIVFSIESDDESKAIHGQVLLAMMYSLVVLGRLAATVVGSNAWTHASLELLQTSVQLYLKKQLLRSQQQDSSDADRPVLTNLSSEMQSHVVAAIQAVAATGRPQMRIKLAYYFDQMYFSLHSATLAIYGRSCGAVPPLDEYLRTIESHRKTSQTDYELFVSTLVDGDIPPDYHAAYEVKPKHGIQLLDILLTRLREGVQLFYEPSMGMNGEMDKVLSDLGRKTKESAKKLTKKQRMNLQKTKPTESTTTIASTTWPAYPLLSQWRDICKTWTDKLYGKAIPNPKALKTIAKYSPIVEMSAGLGYWNSLFPHHKIDSKAFDPSATVAWSPDTDGTDGDVDETASSDAIPKWSEVYQGNADILATPALKSRTLFLCAPPTTTLARDCLRHYKGKFLIHVGEWHGATGDRQFECDVMKSFNLKERVDLPNWGDSAYELTVWERKAKANEAALNIVECSACESTHLSLLKRCVLCKTMVYCSDDCMQHHAEVHTAEHARRLIFLHNDQSLEFDNPLHFAAFDWDIDHNEDFKTTSWKQMAKEDGDKSTSFAFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XYV4</accession>
    <name>A0A6G0XYV4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ADF-H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_000221</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Interacts with G-actin; ADP-actin form.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000001">
        <property type="protein sequence ID" value="KAF0745774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XYV4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000424"/>
    <dbReference type="OrthoDB" id="10006997at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028458">
        <property type="entry name" value="Twinfilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13759">
        <property type="entry name" value="TWINFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13759:SF1">
        <property type="entry name" value="TWINFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ADF-H" evidence="9">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="ADF-H" evidence="9">
        <location>
            <begin position="166"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0745774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="328" mass="36674" checksum="3550D3858BF44DCA" modified="2020-08-12" version="1">MNSQILRVDDSLSTSFQQAQETNTIRCFEVNVEGESLVVKKSYALQNDRSVEQEWASLQAESSSPSLLLLHISPSNGPWKWILVAFVRDTLPAREKMLYASARDCLKQQLGLAYFVGDVHTTELSALTYHDVIASMHNPTGPLSDREILLKEEALMERDLSVKASAMNVMPFEMAADCQAEVDSFVKESSSKWVGLRIEDEKLSLDTAIPNFREDKVNEVVVKDRPSFVLYRYIGSAVSSATTLLLYICPEESNVRQKMTYSTAKASLLDVLQRRGIQVDKMVEITDATSVLESIHAEFTTSNVEDSRPKSFVRPAAPGRGRGRGRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W3L3</accession>
    <name>A0A6G0W3L3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_019033</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000379">
        <property type="protein sequence ID" value="KAF0721616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W3L3"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0721616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="73" mass="8537" checksum="58E36CC11130F3C8" modified="2020-08-12" version="1">MHFKKKVDYRLTEGEDYVKSSWPLWIGLHTSDYGLQLAHIKLESLVIAKQHVAVNMLLDFVHTARHIMEVNSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W698</accession>
    <name>A0A6G0W698_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_018318</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pellino family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000330">
        <property type="protein sequence ID" value="KAF0722585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W698"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002171"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008592">
        <property type="term" value="P:regulation of Toll signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006800">
        <property type="entry name" value="Pellino_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048334">
        <property type="entry name" value="Pellino_FHA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048335">
        <property type="entry name" value="Pellino_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12098">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PELLINO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12098:SF2">
        <property type="entry name" value="PROTEIN PELLINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04710">
        <property type="entry name" value="Pellino_FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20723">
        <property type="entry name" value="Pellino_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pellino FHA" evidence="3">
        <location>
            <begin position="81"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Pellino RING" evidence="4">
        <location>
            <begin position="320"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0722585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="450" mass="49666" checksum="A0CB9E3839FA897B" modified="2020-08-12" version="1">MSSSSSSYGELVVLGYTSYRRVDSAEKIPDKCQWIPVGAPNSRFLLEPSKSQRRAVVPRATRLAKTLTSKTELSTTLRVACKSPASHFVCMPTSPTSSSMFVTEFVPSPSHDMFQVGRQPTVVNDFVVPGHLHGSKGTISRFAVRILCDRSPPYDCRVFAGGFDTDGQMVLPPNAHKFCPRCAQWTKDWTNHLLCLPQVGLPAAQTSDLLLYELDNNQTEDDQEAMDALTRNGVRLWLPEAQAWFEVSVHGRLYAVADPKTDSKRSFHRPTSGPVSRQAVLSHGCLLDIGGVHLKFLSHQWTSQRRNSVSSMAARLEKLNVHCPVQLHPLQFTDEDDAETLPHVYPACGHVCGYNARMAKARQCPLCRTPGVLVPLRLATSNGQRLLSVEERQSPDAVFNPCGHIAGATLAAESAKLRLPTGKSICPFCAKALDATRPFSKLYFYRESDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W6D1</accession>
    <name>A0A6G0W6D1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_018247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000327">
        <property type="protein sequence ID" value="KAF0722648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W6D1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011854"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039120">
        <property type="entry name" value="UBFD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16470">
        <property type="entry name" value="UBIQUITIN DOMAIN-CONTAINING PROTEIN UBFD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16470:SF0">
        <property type="entry name" value="UBIQUITIN DOMAIN-CONTAINING PROTEIN UBFD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14560">
        <property type="entry name" value="Ubiquitin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="30"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="117"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0722648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="289" mass="31950" checksum="C95F11685449BBD0" modified="2020-08-12" version="1">MSSQGPEITIVYGKQQEKLILPLAGSTHISIRELKSMIEPLFGTPASGQKLLFRGKELKDGGSLDVSCLPSKPKIMLLYHGAAKITKIPSSATAVEDVPSVHAQEAAAPAPIELTEGQVLVEVVRGKERYRFAADKEQKMHDVKQHVERLCGVPVAYQKLLFKGKYPDNATILSSLPAKPSLVFMLLFDEQQHIRVEVKQTTSEMQAQLIEYKEQLSRIQGMMARNFFDSSDLLLQLRQLLDAVEILHSNAGIALDTAASDDLRRLVSESKALQEQVAQVHLTLSTLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W7G9</accession>
    <name>A0A6G0W7G9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_018689</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000349">
        <property type="protein sequence ID" value="KAF0722052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W7G9"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0722052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="124" mass="13518" checksum="463F39D9ACF191DB" modified="2020-08-12" version="1">MSSSELVSTAFTSLKERYQTHMNPELGAFSTVHSPSSTLLFCIASLICQHLHNSIESTPPTLLSSSTCQQTLTPGARGPLNQASDCARGQTSFVVDAWFSYSFLNGLKSSYNLQNSLRTQLKPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W862</accession>
    <name>A0A6G0W862_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_018184</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000326">
        <property type="protein sequence ID" value="KAF0722703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W862"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015680"/>
    <dbReference type="OrthoDB" id="21120at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019380">
        <property type="entry name" value="Casein_kinase_sb_PP28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039876">
        <property type="entry name" value="HAP28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22055">
        <property type="entry name" value="28 KDA HEAT- AND ACID-STABLE PHOSPHOPROTEIN PDGF-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10252">
        <property type="entry name" value="PP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="3">
        <location>
            <begin position="206"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="144"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0722703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="245" mass="27742" checksum="F86298C2824AA2C3" modified="2020-08-12" version="1">MSGKGDAAAKKAKSSKRNSLKGGSRKFVTSAEEMEARNRVEDIRQEKRRARRDDGDEEDEDDEEGDDDDVVFDRIVEEKEEEVEELKAAKPKGVAGIIQVQNPNFQTAKAVKAKDIDPNAEPAPLTRREREALEKEAKAAAYMKRHLAGQTEEAKRDMRRLEEVKKRREEAALRKKQEEEAAAELAKKAAKSSIKDDEEVLDARAIKALKPNVLKDYLKERGLSIQGQKAELIQRLIDYENEKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W879</accession>
    <name>A0A6G0W879_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_017688</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000309">
        <property type="protein sequence ID" value="KAF0723346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W879"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005682"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005216">
        <property type="term" value="F:monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="690"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="756"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="831"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="864"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="903"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="935"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="973"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1004"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1035"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="34"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="100"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="133"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="200"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="233"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="265"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="354"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="438"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="498"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="531"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1218"/>
            <end position="1245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0723346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1253" mass="139806" checksum="A31C11152DC4D895" modified="2020-08-12" version="1">MAERTIWKDARHGKALEVQRRLAQGEFVDQLDEQGDTPLVHAASNGKANVVQVLLTHNASIDGHRPDRLSALLRAVQKGSVESVDLLLAHEADVESMFPDGKTPLIFAAAHGVGPMVSLLLKHNANPDAQDEAGNTALLLASANCHSKVVQILIDATANTNLSNFERKTPLCAAASDGHTDVVKMLLSNSNTDVDACNEDGWTALLHAADRGHLDCAKILIDHHANVNATTTYGMSPLMLATKRGYHEIARLLLQNSASVESAVGGMTPLMIAASYGYLSIVQVLLDANADFHAKNSVGKTALELAVEHNHANCKMLLILRENHPLLYFAKSGDVSRLIEALENGESLEDRDETGKSALMYAAVSGHAQVVRYLLQQKADMNVTDSSGATALSLATGESRFILERELLYRIVRAGNISALRELLDENPNMDVDQRDDDGTTLLMAAVDSGEAEIVKLLLDYNADLDAADINGKTALHIAIDGNHRGSQAYLEKEAAFRDNFPLLYEARSDNVNEVRRLLEAGAKIDECDDDGWTALMYAASMDNVAVIQLLLEHGASIGGSDNGGKTAFMVAPDKEAFVKLVLSNSSSDLRFNDIMFKGAIQCDPKLGKAILDEFVIERGRYNLEFRELDRIYGKGEVHESALFSIMHIDDTEPEAKESVKQYCLQHPIIRRVLQLKWEFFAHRLYIEQFLMYILLLVSSMISGSFYQLDETPRDILKELHEFFHPSATPPPTPMPTFENGTVIIQPKTETSGFRWALCIWLFTFTYVIISYLIAHYGLKPKRLWALAKWCRDGTYIEFVRFMIGGNYTGLDWSEEIPDIKIWKAYASKVLFMHSVFWTVVIASPLVAYYGNRSDVEIEASKDLYQGFQNFILWLVAAYFFRWELKEMMGYGVRNYFTSFINGMQIITFSVILFLYVPCQLQIIPESVVSRPTQLVLAGCTTLSLWVLFLQFLEIIPSAGYLLPMMRGLVNDLARFSILYGVFQGGLTCCYYILFQGQQGHENILKSFITVFLVLFGQLDQVVDVIEGRKEEQPLLFVVGYILLMIHCAAAIVLLLNVLIAMMNVTMQTGLENARIEALVSYAQCILRLELSVLPQERQEMIYIIKPKFLKDIQDVENSVSEDELPEFKQVKRQLSKQSTSFRTVHLDELTATSEEKRPLVLPSHSNNYEGKKEKVGILNPAFYEIALKSDYAPLVAMPDESNAAFQNDVKAALALIKKEQAQQIQQLKYQVSELTKTLAEMQSSAPAGSFSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W885</accession>
    <name>A0A6G0W885_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_017707</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000309">
        <property type="protein sequence ID" value="KAF0723365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W885"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011612"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="59"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="137"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="175"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0723365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="254" mass="28320" checksum="75DEA31B5F759FAE" modified="2020-08-12" version="1">MGAAATTVLAQETQLPLDGSDVNTPRGESAKQEVIRLRALLAATAQQQQQQQASSLPPLFAHYAERIFLEVDTDQSGYLNYNELWSLIQEKMNLGLSPEDIEALKAQSGLASDSDVSWQQFLTMLPELLKLQLRQSEASAADWCELSTDAGDVYYYNKRTQLSQWEKPTWDLPQDMQADMISVFQAADQDGSGFLSWEEFQNCLSNQLDLQLSAAQYEAIQSQVLQPDRGVSWNDFVQAAPGLLNNWLSGHGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W8S6</accession>
    <name>A0A6G0W8S6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_017537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000301">
        <property type="protein sequence ID" value="KAF0723570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W8S6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006464"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0723570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="345" mass="37756" checksum="DD462DA62751CF34" modified="2020-08-12" version="1">MLVMTAPSSSPSPFPEDEKTTTTTPATKKWQSDDDAVVRRSVLLHILIVLKQKYGKVDQRISNIARRAELALYTRANSRDEYGNPHTLCKRLHALIVKLYAHQNEAAKKRKGCAAKDTEAPVCKRIKQTATTPVNADVLLDGQEGVLRTICSFLDIASLVAFSSTTHRARDFIPHCITTISLRASNLPCAAPAPWLARFPNVETLVLRGDNRFGFGEIAMENIDMRSNEAVEWLLAGVSGNSVRRLHTLALRHVYCDGLDDPLTTHVAGLVPQLPALRHLQLVGNCMTDVGAIHLSKLRTLETLNVDNNFIGERGGAALNAMASSGSCQLSMEGNLVARGSTPWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W8S7</accession>
    <name>A0A6G0W8S7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-glycosyltransferases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_018008</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000319">
        <property type="protein sequence ID" value="KAF0722931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W8S7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003738"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF145">
        <property type="entry name" value="FI06409P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="574"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0722931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="621" mass="68185" checksum="58E77F4E6A2CA582" modified="2020-08-12" version="1">MESSSSGSVAPTSVAGCVHPVVSAAVSSTSAERGITHVRVQPKGPSNLAWRRATSRGVDHAKKAVPATTEWLWTLKQCVWVVLLVCVVVYILMGEHLATFGLPTCMAATATMTSTTTTIEAAASTTVYVSMVSIPVLERVLPMKYLAEELLHRGYRVSFALPEICRSWVSDVPGLEFISLGTMPISAPSYTLKSAVGNVGIYTSYWHTLQQYAAFQKPMFHPLLEDFLEDPPTLAVVDRYTFAGMDACNAVGIPFVVNNPFLLLDVDDPPSYVPAPLSQHPMETQTVYERCANGLYRLRFRLLNLALSLGLHKSTDHAIYGERVVLTNTAFGLEYSRPLAPLYPMVGAMRRRHVTPVMDAGLESWFQIAPLELEADAIVLVDFGPDVDMPADAMVQIIQVLRDLGCRVIWKLTPDMHKMLKAEDAHPLHEFESWGVYLSPLIAHTAVFPHVRFFLTSGGVFFSQEALCAGRPILAIPFSAEHVEFTDRIVRAGAGVSIQVSQLTMESFRWAAQLLLTHDRFVKAATRLGGLLDSAGGTVHAADAVLDVVHRGTAPLVPARQTQPFFKTYLLDVYAVYGAVLCGVAVILRTLLSACVSVFQRKQQQQQTASEHLHHHHSKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W8T4</accession>
    <name>A0A6G0W8T4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_017556</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000301">
        <property type="protein sequence ID" value="KAF0723589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W8T4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004105"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
        <property type="entry name" value="FYVE_like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="271"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="335"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="396"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="412"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0723589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="448" mass="51332" checksum="5B9A9AE4FE20E195" modified="2020-08-12" version="1">MGRKHRPSGHKHPLPVDFFVCPQTAPHEESALIQTGLTALTHLVRDSQLENGPIAWKPYYDSDGLQIYLATELGSSENIIFMSVTEVEGTLEEAAALHTADTTEEYRKFSERYSKDLIDCAVLKTLAAPTREHPHNYIGLKWVTLEGPPTIRNRDYCFIECRDEFSINDVNGWARVLHSVDLPWVPDLRESMEFVRAVYENSGIVFKESEKPGFLQIYQLYNTNLRGKVPLWVQRFGIKRRARSLLAYDSYFRAMRLGHVPLLRENELVPASSRRKCFLCQTSFGPFAKRYNCRRCGEVVCRQCNKKWEITDDLQITRFVRICFKCSSGPPRAFFDDSEDGDSSLDGGSRAMSEPNIPHGHYRHSMKQGLNRPQAALDDVDRPRQMMRLSSGPPVQKKKDHRPHIPQRHSVQRTSRSGYDDNTVSREELVGLYRQLKQMKVDGDVAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W8Z8</accession>
    <name>A0A6G0W8Z8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_018241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000327">
        <property type="protein sequence ID" value="KAF0722642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W8Z8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002891"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="UstE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251:SF17">
        <property type="entry name" value="STEROID 5-ALPHA REDUCTASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0722642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="305" mass="33151" checksum="754D3AF15F789D99" modified="2020-08-12" version="1">MSIVRQSAGLVAALAIGSAIAFPTHLTLYAGVSLGINWLVALVHAIPNKSELFFDITGSITFVTLSVLVAWLTFPDDSDGVALYRSLGSSLLVIVWAIRLGSFLFGRIRADGNVDSRFVEIRVLPLRFFSVFSLQALWVLICLLPVLLLQTSPQSSVVCVWDIVGPLLFVIGLTLEVTADAQKTAFRANPANKDRFITTGLWRYSRHPNYFGEILLWLGIAVLSIPQLPSLSFQLVASLSPIFSFLLLTFVSGVPQLESKGDAKWGDDKEYLAYKNGTSALVPWFPAPAPLANSGTTYGSTNAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W904</accession>
    <name>A0A6G0W904_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_017506</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000298">
        <property type="protein sequence ID" value="KAF0723655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W904"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007738"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF288">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0723655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="120" mass="14039" checksum="ADCADBACE968C9D1" modified="2020-08-12" version="1">MTFDETKTGNERSGTLNWMSPEQYLTPNLVTRKSDVWSFGMTVWEVLCNDIPYKDYGPYEIPEAIVSDDERPRKPKELSPHLEPLWTLITMCWQVDPADRPFAADIVKYLKKHYGSELRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W9X6</accession>
    <name>A0A6G0W9X6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inositol polyphosphate-related phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_018069</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000319">
        <property type="protein sequence ID" value="KAF0722994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W9X6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010239"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF275">
        <property type="entry name" value="LD06095P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="2">
        <location>
            <begin position="194"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0722994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="516" mass="58061" checksum="196C610CF32B35D1" modified="2020-08-12" version="1">MSTQSLFNTLHKLDDGRRSDAVPIAVFNQAAASFETILIQVLQLDQQFKRAYIFIVQLDIARPTSSDRWEDSEKHRAPSAKIDTEVLGLYTNAVTSDDHRIEPTSQDGDDVVDCEVHIDSSREALAHPNGQLAAGDAKAAASDAQDAASDVRGKLGEYEDSKDDGATRTWPTPLTLQEHIDVSKESTADIAKRGTVRVYVMTWNLQAQKPPEDLGALLRPSAYHVYAIGTEECVRTIAKSVIFQSKKEWEDQLKATLGPEYTKLRSHALTAMHNVVFVHQNVFPLISHLHSDAIATGLGNQLGNKGGVGIAFNIGRTSFAFVGCHFEAHQSQHALQRRNANFHKINTELQLVDPTEDHRHGPITEAFDRVFWCGDLNYRIDGTRRMIDNLLERNFHDVLLVNDQLRKEMLAGRVFQRFREGPLHFRPTYKFDKGSHVYDSSPKQRIPSWTDRILFLSTTPKAIVQRAYESHMEIKTSDHRPVTAIFDVEFMTESTRQDKTALVGSDQTKSEVCCLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WAC5</accession>
    <name>A0A6G0WAC5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_017600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000304">
        <property type="protein sequence ID" value="KAF0723520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WAC5"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0723520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="83" mass="9508" checksum="C6871EEF3888720A" modified="2020-08-12" version="1">MYGRRLQVHWQLCNSFSNSPPPSNMKFVHLVVLLVCLLSVVVAEASRWDRFKGWVSKKGTKARNFKNKLEVTAALDGLKKFET</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WAD4</accession>
    <name>A0A6G0WAD4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminotransferase class V domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_017610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000304">
        <property type="protein sequence ID" value="KAF0723530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WAD4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013823"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43092:SF2">
        <property type="entry name" value="HERCYNYLCYSTEINE SULFOXIDE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43092">
        <property type="entry name" value="L-CYSTEINE DESULFHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="2">
        <location>
            <begin position="121"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0723530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="447" mass="49914" checksum="7DF446E4FE163F88" modified="2020-08-12" version="1">MLHVRRACRLQRCFSSSSVASTGYQAIGSFHTPSIDDLFNEATPRPAPFQVPSVPPLAAFGHDARAAFFLDPTWIFLNHGAFGSTLRLAMHTAQHWREYAEEQPLKFIDRELFYHAVDAIKALAAFVHVAPTDLVLLPNATAGLNSVLESMAAAMKPGDTIYCLDVAYGAVKKLLHHVCTEHGLNLHVEPLPYSMSHDDEAILELVSRTIPSSCRLVVMDHITSNTAALLPAQRLVDLCHAKQIPVLIDGAHGLLNLDLNVDAIGADFYVGNCHKWLCSTKGAAFLHVQPQHQATIRPRIQSHGMEQGFQSRFLWTGLQDYSAWLTLPTVLSFWQNQAPAVRKYIHSTVDQAASSLMEHWHLHETHELPRHKFHAMRLVPLPPSVFGLEKDAQKTSADAKYIQDRLHDAFHVEVPVKCIDGRLYLRLSAHVYNALDDYAYLGHIIHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WAY0</accession>
    <name>A0A6G0WAY0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_016937</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000272">
        <property type="protein sequence ID" value="KAF0724398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WAY0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005091"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="2">
        <location>
            <begin position="174"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0724398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="398" mass="44918" checksum="BC368FDB7AAB4C57" modified="2020-08-12" version="1">MSKTKSKSISIETKLDAISYAMQFGVRPAAKKYGVDPANIRRWKSKQEELEKSNRHRKRLGSGGRALTSAQHDEILFDWIIHESVVGTGAGVGHENTIGMLERRQERQSFHPTKSFFVGFISSHVRQIIQTYNIPLSNIYNFDETAIFLDHTDRTTIDFRGARDVPIRSFGFEKSRITAVFAANAVGSKLPPCILLKSKVADNIRCIDGLVHCSSPNAWMNGPKFIEYVRYTFAYHVRPLLLVFDSAPSHISREVKAFLHSEDILFVVIPGGLTSFVQPADVSWFKPLKSHLKAEIDAWKEMGQFIYTTGNRVKAPDVSVYGKWLKKAWSRITAENVIKSFQCCFLGSDQELSIAKNDELGPLFLMKLEESTRQTAGVDEAIDVDVVDDFVDEFDMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WB50</accession>
    <name>A0A6G0WB50_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cep57 centrosome localisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_016788</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000269">
        <property type="protein sequence ID" value="KAF0724494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WB50"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001148"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051756">
        <property type="entry name" value="Centrosomal_MT-associated"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19336:SF9">
        <property type="entry name" value="SPINDLE POLE BODY PROTEIN PPC89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19336">
        <property type="entry name" value="UNCHARACTERIZED DUF1167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="309"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="104"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="249"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="335"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0724494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="563" mass="60749" checksum="092041E3095099DC" modified="2020-08-12" version="1">MESTTLRASKTIAQTELQQLKETLRRLSVADDIHSSVKMSSLVAPMTTTISTTTSRPDNQKGTSDATTMSSSSPCLANSFATIAPSGFVPSSNNLSSTTGASNSKAVLSALKALQDKLRRVEEEKAEVDAQCANLKAQLRSNEAQQLSASKKASYELQQVKEAAHAAYEALKAERDALAADLSQSKHETAIKANELDHANDMMASYKEKAEYANEQTKHVEAQLVKVQAELTESTLESKERILELQEALHSATRSGKEAARKIQSLEDQLQRANDANASLEGRLHDAEKTVGQMSQLNEKLVHNLWASKAKPKKAAKKQPTAASSTAPQKSTVVTRSTAASRANAAPTTTSLAAKRQTTKVVSTTKKKKKSSSSANNKTQLEVANMGHVPFLLGTSTSPSFSVIGSAQEVLRHSDAYAAVAPDVKPSLLIDTQTAFHDAVDGGDKPTKASFMHNISKAVKSVEAEFQQLNNRYKALVVHVEGNPGVGKSIEKTIDELEAKGEQLFLLKQLQSQASKSSIFAARHVLHSPDAAEKKAAALRVLHEYRKLDREMKARSPRASSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WBY8</accession>
    <name>A0A6G0WBY8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_017359</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000295">
        <property type="protein sequence ID" value="KAF0723783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WBY8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012163"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="65"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0723783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="158" mass="17992" checksum="2516C72EC5E3B86C" modified="2020-08-12" version="1">MSFLDMGSDSGVDSDKAEEDSAQPAPVVAATPRTGLDPSELMALGNVGGPIISQTAQRRRRIDEILSESAENETLKRRIVAEQQETRQSLFQAMLLMEERQQARDHEYKQHLDRFAAAREEREEKRLERQEAVEAQREVRQLKADQIMMALLSKLLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WCU9</accession>
    <name>A0A6G0WCU9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Casein kinase I</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_016229</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="VJMJ01000245">
        <property type="protein sequence ID" value="KAF0725286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WCU9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006605"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013619"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14016">
        <property type="entry name" value="STKc_CK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="8">
        <location>
            <begin position="403"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="689"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="18"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="160"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1024"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="226"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="252"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0725286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1067" mass="120289" checksum="B6DA5A1B67A486FF" modified="2020-08-12" version="1">MEGDEKRQELQVLDAEIDQILSAEPSPPKKPRGFGLGKTRRDNLPPPNARQTMSFGRAQSTDKRVNKRFWADEGRTPDFTTSVLPTSREQNPAPYSISNQFSNKPRPTIPSTRIVPGKALLGTEAKKTPIYSAPHKDLLRVSKPADRGILENCSGGKLWPSRGQVLTPPGKKVLKSTVPTDSSSWRSHDAADDEIDSRHALNRRPKVDDQMFMLKRPLQMKHQTFSRRESAPTPRPFRDSPPRRQSGGTAEKPIHLSDSEDDEKKPNNELELMCRTVLYRTKRYRDKPVKFLEKSLRLTIHEIMYSLIVEVLISKLSPIFVVIKLEGDTSFLALQPSSESACLNLIDRLRQSHGFLPLRELNDADDEEYLKFKEIVIDRQARRVKSSPVVLTYPLPPDATDVITITQEDLTRLQPQEYFNDNLVDYYFKWLLAVKMPQCAPYTICLSSHFFTQLRDNLENVATWFSPQSLLQKDLIFVPINMNVHWSLAVIIRPKNFTLGDTSEQPTVIATIDSMGQFHRRSKILSNLKHFLAAHSDLDEEACQAIKGQVLYGPQQSNAHDCGVYMLLAAQSIMAKFGKARKRGVTIDVDDLLDKHAFSQADVDRTRQVMLDNLNADAEKYAQLMQDRQLLRYRASFPSQPPNSNLRFFDANDIFPTIYHFSFCKDRQGLSMASLTPGSSRFGDDSVQFLLGSRIASGGFGHVHHGINVATREQVAVKIERHAKMVLNQVMYESRLYKILAGGSPSSSNPADSVAEGIAKVHWYGYVGNSYVMVTDLLGPSLEDLLERCGGRFQLKTVLMLANQLISRLEFMHSKKFFHRDIKPANFLMGLGDHANVCYLIDFGLAKRFIDSRTNAHIKYHDKAGHIGTQRFASKNASKGMEQSRRDDMESLGYVLLYCLRGSLPWQIAEKNEQAALKMKINTSVESLCQGCPDEFRAYFEHVGALRFEDKPDYDLLRGLFSDLFTRSGFQSDGIFDWSVPTTETMKLAQESDVVAPPTTLADCNALGGINSLAMSGASDAVKSEGAKRGIPAKSFPSRDLDFDEDAPPKRQCIRHETIESNVSMTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WDH7</accession>
    <name>A0A6G0WDH7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Choline transporter-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_016163</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Choline transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000243">
        <property type="protein sequence ID" value="KAF0725392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WDH7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009942"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF14">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="385"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="501"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="608"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="647"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="705"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="715"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0725392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="738" mass="80237" checksum="3BF1B511704395E2" modified="2020-08-12" version="1">MGCCSSKEDVVPDGSGGVVPTKTRKCRDVLCCVIFIVFWLGMVVLAIVGVANGTPQSLLYGTDFNGTVCGNGAVADSKYIFYPRMNEDMQVQAAKGIQPLSMKFYGLCVNKCPEMGDYICTYAAEAQIRSSNPNANATTLMAKRQARASSSLFGSADCWLVSLPSEAVAFRCLPMQVTTSNSTEMCLAPADAPQYYTTTANGIKVPNANCTVKVTLTTSQTIGEANSNPVLDSLQTTTALVGRYLSDIQKTFGELLAGGGGGAFILGWIFLILMRFCAGCIIWFVLFATIILLGILSVFFLVKGGLIRSDQVDQITTAIQTATTLGVQVPASLTQSQSNTKVFQAAAVISIFFTVVALLVVCFMRKRIKIAIGIIREASRAIQRLPFLVLFPVFPVVAIIVLFIYATIIGAYIYSANGQTTTTQADLQWVNQLNASSANVTPNQLMKIMVAYHFFGFLWTNQVIQSVSMTTIAGAVCKYYWSRDKKKIGRFPILASFLDCFRYHFGSLALGSFIIALVQFIRAVLLYVDRQTKQLQQSNLAVKVALKVVACCLWCLEKCLKFISKNAYILIAMKGRSFCASTREAFALIFANMAQIAVATAIVNLILVVARVAISIAAAIILFLYFDKNSQFDTGGSRELSSLFPPVVLGFLLAWFVSGAFLGVYEMTVDTILLCFCEDRRINHESGQYYMSNELAAFVDKASKKSKPADGDKSVPSTPASPGTKTIEVSSRAKPEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WDX7</accession>
    <name>A0A6G0WDX7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_016011</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000239">
        <property type="protein sequence ID" value="KAF0725535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WDX7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001652"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026347103" evidence="2">
        <location>
            <begin position="17"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0725535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="222" mass="24297" checksum="486CDCD09E3043A8" modified="2020-08-12" version="1">MLPCTWAALLVPLVASQTALPKLTPLADGCCSPTDVTNCKMNCLAHYKDLTRFTCPCYSHMGECLVRIGCSFAQRKQVMTACTRKGYCKAGYCTYRVGDYTPKNGVRPEIFAKTAVVPPDSPCVDGCCPNDTTCSPEDPTMKALRQPGRAYRNEEVNLPPRRGDPRLSVNQDYDLMPYSIPLKNLPPVDDAYMQLFKQQGDSADSTAVSSSGFLLNDTSTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WE14</accession>
    <name>A0A6G0WE14_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH psq-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_015830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000233">
        <property type="protein sequence ID" value="KAF0725743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WE14"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006284"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0725743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="25128" checksum="2E1684C7BB0C90A4" modified="2020-08-12" version="1">MSDAHPNVSKPRPRPNIAQKLEVVELAKQHGLGSAVAICGYSRSAVYLWLSQESKLMDFIGSKTRRRNTGNGGAKPNIPDPHELAIFVRDLRREELPVTSGHMIKFLRINHKEWLEEYMSSRKSGYQSLLRLLQRFADRCDFSRQRVCKQKHTQADLAETRVAFGRQFHGQYGHMDLDCIYNADETGIYYDMCPTTIWAVRGGGAKGERHSYRMTAVLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WEW4</accession>
    <name>A0A6G0WEW4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein preY, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_015708</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PREY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000230">
        <property type="protein sequence ID" value="KAF0725938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WEW4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009509"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005651">
        <property type="entry name" value="Trm112-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33505:SF4">
        <property type="entry name" value="PROTEIN PREY, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33505">
        <property type="entry name" value="ZGC:162634"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03966">
        <property type="entry name" value="Trm112p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158997">
        <property type="entry name" value="Trm112p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00040939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0725938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="82" mass="9326" checksum="779C669E48256DE5" modified="2020-08-12" version="1">MWAMRRTAAMAAMTSRRSFSTTLQDPSVLDHLVCPISKYALEYLPEKGILFCRDIRVAYPIRNGIPILVPTEGRLVPDDEEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WF43</accession>
    <name>A0A6G0WF43_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_015660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000229">
        <property type="protein sequence ID" value="KAF0725995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WF43"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013875"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827:SF1">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0725995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="213" mass="23587" checksum="24A2D450B4B54747" modified="2020-08-12" version="1">MLKPCNVNGCIHPAVANSWRCRHHRHRGLCIVDNCNNQVYARQLCCRHGAKKTCEHDGCTLRARWNNLCYKHGAQKKPCSEPGCGQPAQARQKCVKHGGGRKCKADGCTAHARAGGFCQRHRTAPQTPPASTDIAARNINMMALWGEAKVVDGRHKWASSHDKSFSLEEVKIEPGLVCMVDGIDLMTHSGVEPQHYNDDKAMMRDILALLEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WFB9</accession>
    <name>A0A6G0WFB9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">endo-1,4-beta-xylanase</fullName>
            <ecNumber evidence="3">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_016361</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000250">
        <property type="protein sequence ID" value="KAF0725130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WFB9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012723"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490:SF88">
        <property type="entry name" value="BETA-XYLANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0858">Xylan degradation</keyword>
    <feature type="domain" description="GH10" evidence="10">
        <location>
            <begin position="1"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0725130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="287" mass="31800" checksum="7F654E9B82C95A5D" modified="2020-08-12" version="1">MKWQSHETSPGVFNFQQSLSEIAYAKQHGMKMRGHCLAWHNQMPSFYCTIGCAQTSLSASQFLAAIETRIQKTFAALNDPTIIARDVLNEAVADDVSGLKHDVFYNTLGPNYVSQIFSLARKYAPAGVKLFYNDYGCDTPGTKANQCFKLVSDLKAQGLVDGMGFQMHLSENQNLAGQADLFKKFSDIGVTIHVTEMDVGGSNQQQQASVFCTMATNCQQNPKCEAFVVWGVSDKDSWRASETPLLFDANLQKKPAFAACHDVIAKGHKVKTHLQFMCRQVGQEFCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WFD7</accession>
    <name>A0A6G0WFD7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CBM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_016305</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000249">
        <property type="protein sequence ID" value="KAF0725153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WFD7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005123"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026052650" description="CBM1 domain-containing protein" evidence="7">
        <location>
            <begin position="20"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="8">
        <location>
            <begin position="19"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="59"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="61"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0725153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="152" mass="15562" checksum="B5B68A9813D4185B" modified="2020-08-12" version="1">MKITAILAAVASSLALVQGQVAVWGQCGGQGYTGSTVCASGSVCTKQSDFYSQCIPSANVPSTGPTTAPSTKPSTGPTTAPTPQPSASSPSLPSSKSIYFGTAEDTPTKYGTIIPDNFNLLVAGNGMKWDAHERSKGVFDFSNSLHTPSRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WFX5</accession>
    <name>A0A6G0WFX5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_016054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000241">
        <property type="protein sequence ID" value="KAF0725491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WFX5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007812"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="140"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0725491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="480" mass="54292" checksum="7927C63583C1D25C" modified="2020-08-12" version="1">MDILHPPDASTLAGMDVYKPNKAKDVQAFQRQAALPQFGLNEHVTVVAFDGAIKAKEKFGSYGFVIWQLPGWSVLWAENGVLADANVNLAEYNGLIAALERVLSLMSVANPVIFCDSPLVIHQVADCAVCNTAGPPPCFRALSPGNLTPEGSLDVVCMDAATDMPSSFRGNTQLIVFVDVFTGFIMTKATPNRTAHTVALAFEEVVFRRFEACRELRHDRDPSFMSNVFKYFCDMLGQRQMPTFACRPQANGLAERSIQVMVRAVKHYVQDPKQRDWAERLVFAMNMSVSVVRKETMFFLMHGWDPHTTITASVPTIRGDAEPEAYRWRLQLHQQQVYCHALNRDLVAAAIANRARRHNDQLPEDVDKRIKVGDAVWLYIDQAKPGVKVKLAHRWHGPFRVLSRQNDYSSELESRVRHTGKVYCFHAIVHDSRLKPRRIYLERPVELLRDVPEIDFDEATTPFLVGGPIATMCWARARKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WG36</accession>
    <name>A0A6G0WG36_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_015703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000230">
        <property type="protein sequence ID" value="KAF0725933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WG36"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004210"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026072620" description="Apple domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0725933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="479" mass="53665" checksum="A6F517008E4CF3EC" modified="2020-08-12" version="1">MNHNAVLITLALACGVAVVAQSPGRVSTSYSPDRSVPALDYSYIPNAHWFHRPPPYPSNKSLFAEQELDGSILHQFYNVSTTNECAALTTLHGLTFFTHSSTYALCHGHDFSNGSHVVDANLVGGEGSILPQRQSILSSFQLDISPPKSTQIDNCEQICQSQHGCASYRRHESVCDLYGLTPNKRNESVAGWITKPINSAVTRNLPAFEPTSASRVHFYIVAHEDDAILFMSSMFHQSIEDPSTKVVFIYTTAGDAGFGDWWWQAREAGAIAASQAWVEHFGRFSAEPMVETVQIATSNGTIHRIRSFHVGNVVNYFFSIDERGFDALNAERHPVAPMDDRAVPYSGRDDLKQTLAGVMALESNGMASIQVNTQTFLNATDADDHPLHRENGQLVRDVVDDHPTWRSCVTRCYFFDYQHWLDDVNLPSPARQVQRYAWMRLSQAIFQHKPDLIFWSNHLMNLGRTYIDRIDHATELSCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WH04</accession>
    <name>A0A6G0WH04_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_015325</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000216">
        <property type="protein sequence ID" value="KAF0726437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WH04"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019074"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044772">
        <property type="term" value="P:mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046965">
        <property type="entry name" value="Cyclin_A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001771">
        <property type="entry name" value="Cyclin_A_B_D_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="150"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="7">
        <location>
            <begin position="243"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="247"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="9"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0726437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="369" mass="42641" checksum="BE4A699E9A3188A9" modified="2020-08-12" version="1">MVTRNNLKSQLTQSQTSVSETQSTSSPSQDDQASIQSSKKRQKALHNQENKPPLGWSPESRRPSLSHEQRQRQHSFDIRMSALSSEFDVDVYVKQVRTIDPKHEDALAREVDLFRRKHEEKYRVKHDYLADEKDGVKCDINSRMRGILMDWLVEVGEEYKLVPHTLHLAIHLVDRCLSVMKVARGKLQLLGCACMMLACKFEEVVGPSIEDFVYISDHTYTNEEMLAMENVVLETLEYKLAGTHVYHFLERFIHAGCTTETQQHFAHYLAELAVIDYHITIAYPPSILAASIVYMTRLVTEEKSPWTPTLHYYTKYNAVQVRDCVSKLYKIHNAEYQVSQTDPEKTRAVTDKYMSRKHARVSKLPPVQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WH79</accession>
    <name>A0A6G0WH79_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_015159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000213">
        <property type="protein sequence ID" value="KAF0726531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WH79"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020911"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="1">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0726531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="467" mass="54078" checksum="AA11D3BA4587B1C9" modified="2020-08-12" version="1">MPDYMRRSWWIILTRKTNDDVCLDRILPHRPNIVPFLESTGLDGEILRDLPRTFPNEPLFQSTDGQVWLANVLKGIAIHLPDVGYCQGMNYIAAKLLLLWHKTSVHVEQDVFSVLCGICREHNLLWSPGMTGLRRCIFALHKLMQRHLPALYAHLRRIGIHEGYFATQWFITLFTRILPDDATFAMVWDHFLVDGFKMLYRIALVLLECMQQDLLEMEDMEQATMYFSRNPKAHLLHGKQDNLIEHARRFKITRSMLASLEEERQVQLLHFRMRSSHSDHEDDAIFYPEGDAPVARADLDRIRAEVESMEANVAADVGVFRRKIERIVRAADAASQAYLQATARMSEAAYRLDDVLEWQPKGKPQENRSWGPLNRLWACLPSQNRRRRHVHLADDDDDDVHGAEKAAAVAQLDAARFKVIEAQLNMEELSTLKVKMMQQCVQIVNLSERDKTHRLQSLFDALDNSLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJ97</accession>
    <name>A0A6G0WJ97_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Ae201684_014548</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial Rho GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000198">
        <property type="protein sequence ID" value="KAF0727286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJ97"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010176"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000011">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013567">
        <property type="entry name" value="EF_hand_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08356">
        <property type="entry name" value="EF_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="627"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="196"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF0727286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="673" mass="75293" checksum="7C77342DED61A565" modified="2020-08-12" version="1">MAMTQVHDDSSASSMNKQRTIRLMVLGDEKVGKSSLISALVSQHASERVPRVLHDIVIPTEDTRENVVISLHDTSSHSNDVMEVIKTMNRSDAAIVVYDVSRSISSQRLGYWLDLLKVTKIIPVVLVGNKCDLLPGGSEISRVKSVLSNYKFIVHSLECSARTLTNVKKTFGLAQKAVLYPMAPLYDAEKKQLQPKFVNVLQRVFRLFDVDRDGLISRQELHEYQNTCFKTRMKQEEMDALMELVALVKPHGVATSEKGGGLYFDGFVYLSELAIEKNKPEHCWQVLRTLGYSDTLDLLLPHGHIDVSYDASTYEMCELSAITKQFLKEIFDQYAPLTQTAIETIFVVVPHDKRPKWTQLPLDAPMDFATWISLWSLEVAVRPRRALEELYYLGFITVKASAAIDIRRLPSRHHRSTSSTIRCLLFGSTQCGKTRLVNASTCFSFLSPEPFDATAAAALAEDANAVVVQAYEHLLHNVHTIQEGNLDKTLIMSEVSEGVVDHDMALAIARLIHVDVVCYLFDGTDHDSFEYIVDLQSVVPDTIPCVYAYSTPTPVQDSTTSLLALDACLKHCASLKLDAPLSICLGTADGFQMLYSTLVQRALYPNAGGALPFTKQKALAKKRKDRLFGVGLFALTCVSLGVAYVYREDLKELSKELVRWWRDTSAFPQQLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJT9</accession>
    <name>A0A6G0WJT9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_014359</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000193">
        <property type="protein sequence ID" value="KAF0727529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJT9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002533"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF8">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE GSTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="38"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="125"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0727529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="31378" checksum="15CE3BDD4E0EACA3" modified="2020-08-12" version="1">MEAAEEKKADMPTDGPFQDAAFAICTEEELIQSFAKPGERVLYWGSGSPQAWRVLVVLEEKQIQYRSVCVSFSSGILKSAAFRQLNPRMRVPVFVDGSAGVVLYECDAILAYLERFYPNPLMPTGPKAFAIAETRLREANEILSTVGEMVVYLRRAQANAKKNIKTNTEIIQAKWNVLEAELKLWEMYLDNRQYLVGNDVCLCDIVVFTNIAYAVRCGLQLDGLYPRLAMWYLRMCSRPSVEATWPPHWKTTYGVAVLARCHFCLCQGQCVCSCNGND</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJX8</accession>
    <name>A0A6G0WJX8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_014354</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the unc-93 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000193">
        <property type="protein sequence ID" value="KAF0727524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJX8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002539"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051951">
        <property type="entry name" value="UNC-93_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19444:SF13">
        <property type="entry name" value="PROTEIN UNC-93 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19444">
        <property type="entry name" value="UNC-93 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026343367" description="Major facilitator superfamily (MFS) profile domain-containing protein" evidence="7">
        <location>
            <begin position="28"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0727524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="463" mass="49908" checksum="B8CD389ECBCED145" modified="2020-08-12" version="1">MIQATACLQSALLLSTAFFLIFTASSGLDTLMTSVIPGKCDDCLEGEPNGICQEGNVCHDKVAISCDRVCEAPFQECTSSLGTTILGLAYLTFMLSAIAGPFVTKQFGEQRSMVGSSLAMLYGVVNLIVALNPTKTQLHWFVMIPASIITGFSSSVIWISQASYLTHLSVTYASLQGLPTTSSALGLFTGLFFVGYNMSQISGNLVSSIVLGSLAWSTATLFIIYIVFALSGTFLLSLLPTTSQLALEEDVPTEKTLLIDSVAPSTWISLWNMAQDPRMVLLAPTMIFHGLQQGFVTGEFTSHVIRKSLGSASIGYVMEVYGLVNVASAYVFGKLADRLGPSVGQFLGFVLAFTAYAVCYWANLSTCGDQWTLVLCTAILLSLVDTATTTLVNVILGREFVSDTIDAFSLFRVYHAGAASFSFLVFGYLSFQDRLVVLMTVVCLATVSFTLFCIRHRHETTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WKE0</accession>
    <name>A0A6G0WKE0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_014335</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000191">
        <property type="protein sequence ID" value="KAF0727711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WKE0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007966"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026167854" description="GH18 domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="3">
        <location>
            <begin position="21"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="370"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0727711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="466" mass="50665" checksum="6C1D280C1308EB5A" modified="2020-08-12" version="1">MRTLSVLFAATASLASLDAAYRNVVYYPEWAAEGGYTMATIDWSLITHINYAFAIPQADGSLQFNDEPSSLKTPYAARQFRNVKIGLSIGGGAGSAQFAQAASPAVRDTFVNNAVKMMLDLGLDFIDIDWEFPSTAADMANFVQLLNSLRTKLNQQTFKAELTIASIGYRDALWASNLGSICNTVDAVNIMAYDFTGPWVDVAGYQSNLYTDGKASNSVDNLVQFYLDHCSAQMLVMGLPIYSRKFQDTDGLYKSFNKAKAESDGETQYKELPLAQEKFDATTKSAYIYNSATRTLHTYDNPQSVAEKVKYVQSHNLAGTMFWDVAQDATGDRSLVRTAFNALGGQGALLVSTNNLNYPTSQYDNVRQGSATPPQSSTTKPASPTTAKVTTKPTTKPTPSKGNGCTSYTVKDNDDVYTITVALCKNEDGCQANGYPTITSASGEKCPYWINTGDLLQVCCTKPAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WKF3</accession>
    <name>A0A6G0WKF3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ae201684_014340</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000191">
        <property type="protein sequence ID" value="KAF0727716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WKF3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013666"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0229">DNA integration</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Retroviral polymerase SH3-like" evidence="13">
        <location>
            <begin position="61"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="12">
        <location>
            <begin position="343"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="122"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="140"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF25597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF0727716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="438" mass="49590" checksum="4FEADC446E8DD405" modified="2020-08-12" version="1">MEMALAMLIHARLHKKWWAEAVNTAVFILNRVVHTSKSTKTPIELFSGHVPTLKNMRVFGCKCFNMVRNPEKRNKLEPKATLCIMMGYTDNMKAYKLYDVENKKMTHGVHVKFFEDEFFGDQTLPQNIDDDDDDEDDKPPINPTASIPPPPPGIRTGNSRISDVIRTATNAARAAATQASNTLWRSLAANPDEPYDPRYDAQAPEFNPFHDLPRRTPSLDVIIEGDNTTQQQNEPQVNAPVEHMAPPQAPLRQSSRLRVPTTRYQDSAALITPLDTNLERYHIDNFMPEREITYRSDGVEYACNAAVQLHPVPQSHKEAMASPDWRNWKAAEEAEVAQLLALKTWTVAKPPVDRKIIRGRWTYARKTDAAGNIIRWKARWVLKGFNQVEGVDYDESSSNVIKMTSVRAILAVATARNLVIEQADAINAYIQAKLERPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WKY8</accession>
    <name>A0A6G0WKY8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_014144</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000185">
        <property type="protein sequence ID" value="KAF0727916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WKY8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014137"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
        <property type="entry name" value="FYVE_like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0727916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="429" mass="49807" checksum="A12D8927020C6C58" modified="2020-08-12" version="1">MPQFKCPSLPEELVHDLTLLSNQSTDELLHRATLSSQSMTWQPLVIDRTLQIYQGFQSPNDRPDEGLETWMCRSVMKSSFDQVAAMLRCYSNEAWSSLLRTTLPDIVDGSHLYTLVKSRPREPFHRYAGVHWALQRNPTYVRPCDWCFLESHQMKRLSDNKRIWIRSFKSISLRACPEMRGVNRATFLCAGFIFEETSGRDGLVVAQFFRGYPRRPVDWIAELTTSSVVLAKTLRQPQIPVLPMLEAKQQTLGDATSSSWPCCQRCSKRFLLAKRRICHYCFLTVCQNCCQDSIVFVRNQRVKLHVCNPCQWIHRFSNFSHCDPRDSFLERDEMPRCRTKSTDSNCSEDTLVACNNSNAPTYQPQASLGRFLSMFQLELQQDGARGKFRSSKLSRKTFLEVDEEDLPQYRPMYLLDEYCHQVRLSKICS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WLG8</accession>
    <name>A0A6G0WLG8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 15">E3 ubiquitin-protein ligase listerin</fullName>
            <ecNumber evidence="5 15">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">RING-type E3 ubiquitin transferase listerin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Ae201684_013952</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the ribosome quality control complex (RQC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the LTN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5 15"/>
    <dbReference type="EMBL" id="VJMJ01000181">
        <property type="protein sequence ID" value="KAF0728126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018789"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16491">
        <property type="entry name" value="RING-CH-C4HC3_LTN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000038">
        <property type="entry name" value="E3 ubiquitin-protein ligase listerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039795">
        <property type="entry name" value="LTN1/Rkr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054477">
        <property type="entry name" value="LTN1_E3_ligase_6th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054476">
        <property type="entry name" value="Ltn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054478">
        <property type="entry name" value="LTN1_UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039804">
        <property type="entry name" value="RING-CH-C4HC3_LTN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12389:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE LISTERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12389">
        <property type="entry name" value="ZINC FINGER PROTEIN 294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22958">
        <property type="entry name" value="Ltn1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22999">
        <property type="entry name" value="LTN1_E3_ligase_6th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23009">
        <property type="entry name" value="UBC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 14 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-CH-type" evidence="17">
        <location>
            <begin position="1576"/>
            <end position="1635"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="16">
        <location>
            <begin position="1584"/>
            <end position="1631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF0728126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1635" mass="180824" checksum="9CC14B6AC2FCBC70" modified="2020-08-12" version="1">MGKKGINQQEKLAKANASSSARAAQSLLGSNATTGFIGFGAFATSAPAPPVQEAAAAPTQTTSFTFYDGDDTDLSLALKMLGKRDAQTKTKALATIKDTIIPSRKPVDLRPAIGHYCYLYGKLMLDNDRRVRQMANDVLGAFIDRMKKGTIFHVHMLLLLPTWYILGMHDLHVDTARGATRAFHTLVPEEADRTALLTTHVELLISNIKAYLEATVDSLSDRALCTADEAEERYERCVTSALVSASSLIASIPVEPNTATWTELLGHMGKLSTLTSKSVTFSRASIRHATYQLLLSATTSAPTLLQSAVEPKVVLGVVGEKFPANISTVWTLVLSYLDAVPKENLPWSSLQGNILPKVLTAIKHAFYGSTSAMANILPFVSQVPFDIISPVYTDLLSAFWKGLESPNVLHGQTPVVQAFTECLLAVSTIFPSSVAASIDDDTAYVAQFKDVVSTAWSKALATVSTLPDRTFQVFCREMTALLPRLTAFQQRTSTSTIAMHAISLLQASLEDVLLRGIQDGPMQDARMLTVLQTAKNTYEGALNDTLVELCRRLAQVLLTKGQLSRRGLEWIGHLLELIGWNTLFPDPMAAIASYHRAIAPAFEADKRAFFVVWKHFAPHAPDVLWTQLLQVWDRDDVAEWKKSALTPLKSLESWLQGGSAANLGVHETIWKSHWFDSRVLLILNAPGDASWTDADDSFFSACWGASQPLVSPTTIRQVVAWCHKNKDSPKCWSLLRSLLPLLVTINTNEIWGDVVDLVDAVVSAIPRHSEAMSLWRDVVQPSFQTWPATYTSMVEGNWLDLLRQFLEDEASCTASQWAVLCGEFITSRGGKEARHPWHALPLSRVSGTYRELECMAELCHWQSGKLIHDAYLTSLTPVEILPWFVLDVGFSLTWYVVDTTDPTVLSEHVGAWIEPYLMLADLWESLGDTAHLPQMLLHLVAKYQAKDDASDVTAWFSAIMSAHMDQKVPPAEETPLQLYIWMLQIGLDYVSTEVLVSVLDEWASQVDATPLVCAALPRLVQCAIEGNSKDTIQPLVEPLLELETRALDVASLSRLAHLLPLVDDAFISSIISRIPSFVKSPPSILLLSDWLDLADFVLAVLDSPFVETSAENATSVFHAVGQLLLHAISAKHDISEVVGLRLHSTAVQTPEDLVKVHPLFMRGRFVLLKLMQAMARHGQDHSTIELARHHREALTLVALRSIVDGLHLKPTFHVAFAAHTPTVAASWATIVHTHDVYQAFTTSLIGLHHVLEFVQDDAVGSTLLQLSQGRDMLWHALSETLTHPTLQAGIYHVLRLTSLVVAIDNVKDLVDVDGQEDAMDTAIADLVITPGLHQALQQHLVESTSAPLKLLLVWDLYLRMFPETSNPLVTSALGAFVGRQKLLTPLLTLCGHVLQSSKVQLGSNEAVEGAFPALDGLDREIAVAPLAAAVFYRTVVKLPTMVRLWWNDECSRSARSWVSKFCEELVSPLMLNEEIQSIQAASAEQSLWDPDEMTVRGSKVSREITTTYLKDECSLEMVIRVPPSYPLRTVEVECTKRIGISEERWRRWILQILKVTTSQDGSLLDAVLLWKSNVDKEFDGVEPCPICFSILNPKTMGLPNLPCRTCNNKYHNSCLYKWFNQSSKNKCPICQQPFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WLT5</accession>
    <name>A0A6G0WLT5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha 1,4-glycosyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_013836</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000179">
        <property type="protein sequence ID" value="KAF0728285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WLT5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017249"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051999">
        <property type="term" value="P:mannosyl-inositol phosphorylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051706">
        <property type="entry name" value="Glycosyltransferase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385:SF23">
        <property type="entry name" value="NUCLEOTIDE-DIPHOSPHO-SUGAR TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0728285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="36287" checksum="BF3A37E4A1AED9DD" modified="2020-08-12" version="1">MALTSSWASHGWFRGLFVAWAILALLVVWRQSQVVLDRRFKQQGIASSSELVIPKIIHQSWKTAERIPSKFVPWMQSWQRFHPSWTYMFWDDDDNLKVFQVHFPQYLSVATAVSKIELADMARVALLYLYGGVYVDSDFECLRAFDDLRHLSLFLSAEPRVHAILLESLETPRLWNAILASQPRHPFWIAILDAIQANFNAYRDTSDPIALTGPGAFDPTYAAWPDKDSVVVLPEEYFYPEFSAWLVPNMTAACKSSNHIPAVASACTWLNQHPQGHKTSNTHAVHRWQCTWCGRGSKANESFTTLADAAPNHARPKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WLU0</accession>
    <name>A0A6G0WLU0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Leucine-rich repeat-containing N-terminal plant-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_013902</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000180">
        <property type="protein sequence ID" value="KAF0728251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WLU0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021182"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45617">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45617:SF169">
        <property type="entry name" value="LRRCT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026202287" description="Leucine-rich repeat-containing N-terminal plant-type domain-containing protein" evidence="4">
        <location>
            <begin position="19"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0728251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="30557" checksum="19C8E1D5A16D88D5" modified="2020-08-12" version="1">MPSLKSVVLASLGALVGANTSLLTCSSNASRFSLQDQSGHVKVVEFPNAANGTLDLSSVDIQTIQSTGCTSLSSLNLSSNLLSVAQDILLLPPSLELLDLSYNRLNILENVDFASFPNLQTLILKGNNLSALQNVSFPSSLATLDLSDNPLDTVVLSLESFAQMVKMNLSMQSIHQKGQGNVDTKRICHVGQLYYIPANGTGIDQVGGHGTSNAVCVVNTETALNRGKSAKGLAIIMGSLVLCLVVLVAALVYNVKRSPCRENLRDTFVSSCQCNDSPMSLETSVIATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WLV4</accession>
    <name>A0A6G0WLV4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elicitin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_013856</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000179">
        <property type="protein sequence ID" value="KAF0728305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WLV4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020136"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026273950" description="Elicitin-like protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0728305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="156" mass="14977" checksum="D0E199EF6EE7339B" modified="2020-08-12" version="1">MKTTAYLVAALVPLAYAADCTDSDFLPLATSVLACSAASGVSFTTSTFNLTTAATLCKYTDCKTFLTGLGALKCTESGESLAPAATLCSAVASANSTTGSTSGSSSGSTPTTTASSSASSSGSTTTTAAPSTTATSGVVATVLSSAVVMTAAAAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WM28</accession>
    <name>A0A6G0WM28_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FATC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_013721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000178">
        <property type="protein sequence ID" value="KAF0728356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WM28"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016497"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016242">
        <property type="term" value="P:negative regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF9">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FATC" evidence="1">
        <location>
            <begin position="63"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0728356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="95" mass="10963" checksum="0CA6C5A11C0190FC" modified="2020-08-12" version="1">MQFIVGPSILSLHKGVMSKFDMNMTLKEDDLVLQPEQLNAKAVKVIDRVKKRLRGRDFEMDGKALSVANQVDRRIRQATSHENLCQLFSGWCPFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WMT8</accession>
    <name>A0A6G0WMT8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_013592</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000175">
        <property type="protein sequence ID" value="KAF0728633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WMT8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006559"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013904"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF37">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="680"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="217"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="600"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="711"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="831"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="226"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="239"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="600"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="658"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="712"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0728633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1207" mass="139124" checksum="D275698870634F4F" modified="2020-08-12" version="1">MRMRIRKPFRILRRKAQANKPVKKSNVLMKKAGPNAAGKRTRSALNEVKERTPSAPAASSAVQQEDSDEESSDDSDSDYSVEGDEVRVQTQRYDWLTSAGVDEETQNQKRSRSPSPDYSIFTDETTDVQRKLFYQLAAAVPQYTKKNIDLTHDKYLKIHNAALLCEAAQQLYNVTVRRVCGVDRQAYDSIEEYLEADNPFDFEDEELRRAKKKVRRMEEQMMGMEKRKKPSKTERRRMHAEAIADRKRRNAEIEEQQKEEKRKAQRVEDNWTKGMSPPKQNLPPGSICVTDPQYGKDRRDVIVLHDATFQDVQDHHDAADPQDATRYGTDCRDVIDLNRAADLLHVDDLAANHADDLHQMDDLAWNQDDDLQHGHDLVVGHQEDNLRPADDLAAGLQDVILTKITHLAKYERQHLIEWRKKRIKYESEVQGMAVEYGLAWRSYIRKWIDSIEPSLLTALCEYQWYCKREDLTEGQFQRYILDVIETRPSKRKVTATNLKKALKDVTMEAKGEVNHRLVSFMEKVHDAITNHCLWQPLEEKDTRKVFIRAVIDKIRPPELADQVSENYEVAQGKSTLRELSELIREQMVWMQDCDELKEKHEYGRSKHTREDNEPSGKRHQLDSTSKHRRSEERAAPRSRQDDLRASTRHNQMISKYDPSSEKSDKPKVKFESKTATELVCFKCRKPGHRIADCPEKVISGVQVSKKLSNAVSRHRYHERKKAKAKRAKSETNQERYVNINSALNCLYCPDTGAEIDIIPMSILEELKTKCPTLEMVQLREPLKGLGATIKDSNRMLMWNLISQCKHPRAQSEYLASASTLRLVGINIDRILAETAQRMACEEDDLEETESECPRLRRRSIVMLRTTRLGLPKPKTELETALAAMVQEACDEGFPADLASRLWQALTKHDIWRLKFNGSDPPAKVEPLKGRPHNPLETRFLALFGKELLDAGVIRHNQQSQWCSPVNPVIKPEGRRMLKAADKWTDDEVLKYYRLTNDYRMVNARTIPKAGTMPFQSTITQHLRGKKALGTFDMPKCFWQFPLDPSSQDMLSFMLNGWVMTPNRVMQGHVDSALYVQATSEDCYAPLLNKHLLVWIDDILVYADDPDEYTAVLDNPTKTKLYTKQVKWCGRYLSEAGVKQDPERIEALCAIPEPTNAGDLQQFICATNWLRESITEYAQTIDSLQRCLTHALEGKSKKKRIARAFRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WMZ7</accession>
    <name>A0A6G0WMZ7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA primase large subunit C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_013654</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000175">
        <property type="protein sequence ID" value="KAF0728696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WMZ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002492"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058560">
        <property type="entry name" value="DNA_primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007238">
        <property type="entry name" value="DNA_primase_lsu_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537:SF3">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04104">
        <property type="entry name" value="DNA_primase_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26466">
        <property type="entry name" value="DNA_primase_lrg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0639">Primosome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA primase large subunit C-terminal" evidence="8">
        <location>
            <begin position="223"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0728696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="402" mass="46328" checksum="F5488857880E76E0" modified="2020-08-12" version="1">MEHILYQVPPSTPIALDDLEDATIRRLDLLLSLQGKESTTYNCNIDKDVHGHFGLRVVFAMIQASSAEKTDMCEWFIKQETLLLQQRLLESIQPRRDLIRDMLQALDAVSYDEEDNNLLVPFQDIPFLVRSRSVILRSGVAHIPLESRHAVFLVAHHARKHFESQLEIQARACCVHPASFELERLYPLRVQVEKALQDALSSRSFVSSSLEHIGDKAGLERYERCLPLCMRYLFDKLRHDHHLKYEGRNQLRMFLKGVGFTFEENMIFWRSMLVSKAFDKKYAYNIRHSYGLVGSRFDYEPWSCATIQNLPPPSAGQFHGCPFQRWESEFLKRQLLQYGGISTTTASQIASIAATEAPVATCRLYLAQRFPRAAPTAVAEKLNLIDHPNKWFDLARRCRTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WNQ3</accession>
    <name>A0A6G0WNQ3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_013289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000170">
        <property type="protein sequence ID" value="KAF0728988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WNQ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008502"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008503"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0728988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="378" mass="42586" checksum="AD0EA0FFFFB08CF7" modified="2020-08-12" version="1">MYFGLWNDLEFAAMNYYSFLLNDPNNQRFTAPCSYADYILDPANYMCDPCDPTWNPDWTMCSVNHEMVLGLPATAVFELVHTNIGPLKSIDLYYVRPPLSLIKMFSTFQDRLSQFVLSGDTSFVASLATIPNTRIDPVPPSWNQSEYVYSGGDPTCIRSTMTNFVQTSFAFDTSCISSDTPTILLTRCSALFALWATSQTNSSIDCNLCLTTTEYCILVLNVTTHVISKFSQDFQTKNTLSNIAIYEAYKIIADLGVSMIRFAVSLDDSSSILLRRQILGSTVQEWDFFGWLYAYEWVQGYREVVSFEGDAGVISIISDKYDPFITQAQELEVPRSACVILWTVTIFTSVVFGFVGALVVGFILLVRIRVVGRNFFQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WPE6</accession>
    <name>A0A6G0WPE6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_013190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000167">
        <property type="protein sequence ID" value="KAF0729213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WPE6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003610"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="32"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0729213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="253" mass="28328" checksum="127241B1DA001674" modified="2020-08-12" version="1">MSPSNDFHPQYPSIDYNSVPLDHLESFLSTDGKLHLFNYIGCPYGHRAIWTAIEVNAPFQVVEVSLANKPPSYTEMFNRYGTVPFVLDNGFAVGDCRADPQAASIAQLAAAKFDTQPFFAFMATGDEAAETKMKASLDELEMIYRDDAKADRDQGPYLLTEIKVYTWSSTQQCGDQHRPLFPSPEPRAGSFPKAAFDAVQARPSYQRSIASDDVYIQIMTNYVRKESGRVYVDIFLKKNNPANAFSTCLCQLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WPT8</accession>
    <name>A0A6G0WPT8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_012918</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000164">
        <property type="protein sequence ID" value="KAF0729417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WPT8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018333"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF9">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="37"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="70"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0729417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="134" mass="14506" checksum="0B4706F2E4186072" modified="2020-08-12" version="1">MNGIDVDFTEAISNGEMEIVVNMVETGLVDVNVPDRDGDLPLLVAAKKNQIAIVEYLLQMGALVDSVDENGWTALQEAALCGAEDIVRTLLKWGADKSIRNREGQHALDIAVQFGHGPVVFVLCEGHDPTIGFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WPZ8</accession>
    <name>A0A6G0WPZ8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_012934</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000164">
        <property type="protein sequence ID" value="KAF0729433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WPZ8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008909"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="10"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0729433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="337" mass="39385" checksum="1499F2C2135F2A78" modified="2020-08-12" version="1">MLPMDAPSEMTIFVRLCQRQANDKFTARVSSLATVETLQRFVVSQWQITKNPLKDVPLSQHIFSFQGRILRHDSHLDVYYIGDNDTVYIRFPDMGPISNPSAMSSSELREELLARGAYEPNLRPQQLMHKLEQLLQRESRLERLQQATKRGLVEQAKAITQELKALERSNETMVEVRTVVMPPRPRSIRWPTPPSRHRTVFFSITELERQYQLIPRDVLEPALFLLDVEREWVFSRHHSVQKASFDYKYLAFDKDFVDLLVFKEEAQLVFWFQPDRSYEKLSAFLTKTIDPVVGKTYAPLTIEPNRWLALGGHDGWEGKVRRDGRRQTTRPIPVYTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WRV6</accession>
    <name>A0A6G0WRV6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_012215</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000155">
        <property type="protein sequence ID" value="KAF0730211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WRV6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012329"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
        <property type="entry name" value="FYVE_like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="START" evidence="6">
        <location>
            <begin position="144"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="5">
        <location>
            <begin position="260"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0730211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="44524" checksum="DE75DE4650720135" modified="2020-08-12" version="1">MKMPLPPEYFQCPPLSREECEQYEHQALQNIQELLEKADVTNPRYEWQRVSHEAEIEIFRGRDSSTLTSAALFCSTLDIAGTLDEVANIFRMRTRDEFKETIDRSDSALLDGAVLYTVQESSSSDIRLHWLLEKKPIDVIGKERDFCFLTSTQLLDRDGNGRHTWIRCFNSVQIPSCPEFSNVIRALLYCSGFVCRESERPGYVNLMSVMHIDLRGTLPSTLKERAVMDLCRTVRVIDRNLRENRLIETPFLPGEQFVKLSSREQCYLCKRSFCFFRKKKNCFKCGEVVCTQCGPKWNIKIAGTSVKVRACTTCSLLPWPSLGRNTAVSTLITPSSIPSTDVWNRADVDDSDDDDDDDEESSFVSFITASTMSRYSISTGGRPTFDHSQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WS07</accession>
    <name>A0A6G0WS07_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_012209</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000155">
        <property type="protein sequence ID" value="KAF0730205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WS07"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014158"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
        <property type="entry name" value="FYVE_like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="START" evidence="7">
        <location>
            <begin position="140"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="260"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="324"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="326"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0730205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="381" mass="43154" checksum="43B875B28E679BDD" modified="2020-08-12" version="1">MKFPLPVDYFECPPLSPLECEIFARQATQNARDMLEKASIANPTYQWKRVADEAEVEIFRGKDPFTPATVTLHCATIDIAGTMDEVARFFRNDTAEEMKERAQRTGHGMLDAANLYWVNNTPESKARMQWFLVRTPFDVIVKKRDFCVLESTVVYDADENRRRTWVHCVSSIEIQCCPEFPNVIRGVQYGSGFICRETDRQGYVNVVSIAHSDLRGSLPMAIRDMGAKEFCRTIRDIDLKLREDRLSGSPFLSGEQIRSLSSRQRCHLCKRDFGHFRKKKNCFKCGEVVCTQCGPKWNVKVEGTPLNIRACTKCSLLAKSSDRADSITTPSSMSSTEVWRVADSDDSDDDESSFGSFVTDRSESNASSTTDGRPIFDDSFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WUL5</accession>
    <name>A0A6G0WUL5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_011464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000146">
        <property type="protein sequence ID" value="KAF0731201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WUL5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009819"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0731201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="380" mass="44095" checksum="228B6DF011DDE54D" modified="2020-08-12" version="1">MENSMTTQSKHANREDLVVSTHALNQREYFRNKRRNYRQRDRDEIERLSAEVQELTARLQSLQVQHKVDLHPVNQDELALSWRTITCRLRGEARVCQAERDVLVERFKVQMQLAREMQQWVMVTESIPVSPSTLIPWQHVALSAHPFHRKHCKEWATQQMYHNTDAAFQAFPRARLDDEIFTFDLEVTEMCISFASYSQIIWPAPLETVRFILRHHLNDISFGPVQFVAIEWTENTVLFQYKASIPRDDEAKSISSAVQALFYEADRCVFVLRQIQGDGLSEVPLRQQQDLLWMDLRPLDDAKTCTRIANFGLLHLADAGVDNLDAMAAGLGEDTSGMEEAEKIAVLRRVLRERAWSGDDTFRRHLAANLDKLRHEARLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WVS0</accession>
    <name>A0A6G0WVS0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_011202</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000141">
        <property type="protein sequence ID" value="KAF0731582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WVS0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002648"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13999">
        <property type="entry name" value="STKc_MAP3K-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000034">
        <property type="entry name" value="Kinase suppressor of Ras 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF289">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE VIK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="17"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Death" evidence="8">
        <location>
            <begin position="198"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0731582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="291" mass="32527" checksum="A15D12CA4892C9F3" modified="2020-08-12" version="1">MTTAEGRSWKSIRFQELTVGDKIGGGGVGIVYRGKYLSKPVALKTLFDPRVDDSLKQEFMDELHVMSKLNHPNVVAFIGACLEAPNLCFVMELCTMSMYELLHTTNDPISVASLVTMATQVVSAMRYLHGLSPAIVHRDLKSQNVLVDTRGDVKLCDFGLVCTKERTAGTPAYMPPELLAGKPFSKAVDVYMFGVLLWEMFARDVPFRGYDIDDIQRKVLHGDRPRIPTTDCPPPCQELIRQCWHSEPSCRPTFDAIYDKLKHVDASKTVQAVDSIVEEDALDSLLMGKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WW66</accession>
    <name>A0A6G0WW66_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Anoctamin transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_011069</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000140">
        <property type="protein sequence ID" value="KAF0731767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WW66"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003074"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF73">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="763"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="7">
        <location>
            <begin position="231"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="577"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="596"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0731767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="865" mass="97974" checksum="F8BB0DC8110E71CA" modified="2020-08-12" version="1">MSETHDGALPRQEAAAIEACVDEILTDTSSRDALTIDIADEMNDAAVERKLSRASSLPQSTLTFHFAILVKLPRLADMTFDPIVLGGLHDLSKRLALSGFLVRLESRAAFSKKHAPHLKLVFLLHAPDNILADMQSKMEIERWVAGGRNAQHFLAPLEHAPLTSADRIVLVDRLLHLPPRHGGLGLQDVACPFKAFPLHDDKFNREYLKPWLLQWRDYLRNDNRDYIEKTRLHFGEKAALYFAYMDFYTKWLLPLAVWGLFTYFLSAFSVPLYFQLSAITGIAVSTIWGTLFLIFWKRKRSELRLAWGVGAQEHIHVVNPHFRPQPTAAGLNYIKWTRRLKYVVGYLILVVFIVGEIVITIGFVDLYFYLKAGCGGHCSPDGLENWLLVLCQGILLGLVVDIIQYQIFRVLAIALTKWENHPTEKRYESSRALKVFLWDFFGIYSWFWMCAFVYVPYGSEFSKLLNEYELLPWRSSYEPGLLELQSMFVTPLVATQGLKIVFEKIIPYFLLQAGRRARESRGFYDVYHSTLAQSFSRMKQSNMTLSSPRKTPRLSTFLPSAIFTNKFGSKKLAQIPPPAEQIQPVETPSKPSPPPPRRRPRSAKRRHVDSSAQQDAKFQQEQQWFLDRVLEQAHQSPHDLFADYADALVQFGYVIQFTCVWPFIPLCALLNNVFEVRSTAFQMAYASARVVPQRTSSIGSWNLFLRFNTFWAIYINVGLVCYASGLLESFFPECVSQQAAVGYAQHLPPMVPNFNCISTTTRFSIILILEHLLVLVYFVLINSIHTVPSSIKSILKTKEKVLKEHFATTGGGGGATAIHVPTDDELAQNEMSHQVLQNQLVAALATGLSATSTSSDANVSPLPTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WWE6</accession>
    <name>A0A6G0WWE6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Choline/carnitine acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_010842</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000138">
        <property type="protein sequence ID" value="KAF0731888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WWE6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002993"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004095">
        <property type="term" value="F:carnitine O-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF16">
        <property type="entry name" value="CARNITINE O-PALMITOYLTRANSFERASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00439">
        <property type="entry name" value="ACYLTRANSF_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="5">
        <location>
            <begin position="42"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0731888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="615" mass="68243" checksum="54319332F73805DA" modified="2020-08-12" version="1">MKARQVCQAARRALSTKAEEPAKHPGWFLKMVNNNDYNLPRLPVPQLNDTLEKYLKSVQPLVTPDEYKEHRKLVEDFGLGANRSVGRTLQDDLLKQEFLNTMGRAYPFSYIEEWWDAMYLGGRYPNPINVNPGYGLIDEAKGSVLADPLTRASSFAVSLLKWFHKVKSGELDQDPNQCMAAYAKQLGTAKIPQKDMDALKFHQRSDHIVVLHRNAFYKIKVYDGKKVVSQASLQAQLHKISTNGAKDAPNIAVLTSEDRDVWAAARDGLRREPVNAASLDAIDSALFVLVLDDSSATESELSALTLHGAAGANRWFDKHQVIAYSTGHLALNFEHTFSDGTNWNRWLLESWHDMHGTDSGFKPLPTLESFDTAHERLEFKLNNTDHQAIEAAVVRATADTANNQTHLLRYKGYGKNTIKTWGLSPDGVVQMALQLAFFRQNQRLPPTYESCSTRGFFHGRTETIRSATSEALRFVSAVTTDAPIASQREFLVKAVDRHVANAKEAQKGLGCDRHLTMLNHVAKTKGITHDFLSSPIRAGSSNFQLSTSNVTIPILDYFCFGAVVPTGYGVGYLIQNNDMPVNITSFVNCPTTDSVAFGAALADALDTVRAVAESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WWJ0</accession>
    <name>A0A6G0WWJ0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BROMI C-terminal Rab TBC-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_010874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000138">
        <property type="protein sequence ID" value="KAF0731921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WWJ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018469"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055392">
        <property type="entry name" value="BROMI_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23440">
        <property type="entry name" value="BROMI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BROMI C-terminal Rab TBC-like" evidence="1">
        <location>
            <begin position="1082"/>
            <end position="1215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0731921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1255" mass="143450" checksum="719168F9ED9F8D94" modified="2020-08-12" version="1">MDAVGIKQAIGLVFKQLPDKLTLHDGETMEVAVSRLKESMEVMCRENPLFWKLDLVARVKELLDENTTSCIERLVEREMAVDPTWMIHDSTLAANKSFQAVVDDLIADHPSAFLRVQRQIADKTTSEVRTLTSHLHKNAKSASDVKTFFHDSAKGLLAEATSRPKRRATQNDTEVLDLDKFVCDEWGDTEACAINGEGGPSMSTILTRLAHTTSTTTRVDALKLLHQTPIEYIIHAELFHTICTALIPPMFHPDTSQSALNLYWKLFHATEDITTQCTLYIELITTLFSLPHSLTSLRKQSVLANPVGQKAVLSFFRMLHELIQFLPREWIYAPNDLRSKVMLLTCQLFGEFGELFDTSEGNIAPHCILAWLDPTAQWFALWHRKSPLKEQWLHLVVDSGLLAQLVMRFVWSYESMESWRKLDNEQKAPAVLTHRRSGRAHAHPQPQNNQTYSGFMQRSFMQTAFMLLDLLPQARIQTAFPVVVKVPSKAPKHSGIVLNHELIADESSNNLIYRFVQETRHMTSDQNLNIAYDHFCLHLVLMCVLEGWIGDLWEKPMVPIIPPQEPHTWLHKVEELLLALKTETIYISLLEVVQELLDLLKEPPPTRPPQSTLSFRFPYSNLSTNLFDSKFLLVLFASQIAVRGEDPSQLSMHLTIFLLPLVVRVMAKAVRPTKTICTNIVQLMNGQWVSFELVSEVAKMSLSIQWFYLLNLSGIVPLLRTYLMNNPQNPDELVTILSQLCATSHGLLHFHDQLSNISLESLWANVFPRRPMSILCHLANVPQVCTAWLRSPTLQAAWRQAVEDLNSDIEGLDAVYGPSASCPYKLRPSLNELLALRRIYCTQYASTSLLDPHQIAPSSSDVNYQVVAMLNFQLSSTLRGAQQVQDIMGDRFPPCSCKASPFILDPPTWMYHMIRQCLASVGGSSEVCSISPMEIATNVIPLLQYPSEENVRMLHRHVQRVLVCIEESTNYLDFPRVAESFWETIACFDTQFQFSTPEATSWFGDIIWHVVVSGKSRLDLSQMNDTFDDDIPINQPVPDEALQWANHWTKIYATGIQNISDPPACSTRFPFLFQALGMEANDPFVWSCLMLLTHRRNDMEVLHFLRLVRRSSSSLYFWPERACTKFPKANVPMFRIAAAVEYILAAEFPHITVSLERQGCSVLSLLLRWHSQCFWNYLNWPEIMIYISLVCIHGVESEVYLLVVLLHHIQDQIRELEYEDLLRLRIPNFHWSSFRSLFAHLHKTYDVVVHEFVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WWS9</accession>
    <name>A0A6G0WWS9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_010933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000138">
        <property type="protein sequence ID" value="KAF0731983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WWS9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009322"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="82"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0731983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="233" mass="27610" checksum="BC84D5431C286079" modified="2020-08-12" version="1">MEEVALLKMENAMLRQKIAVSKKASLMYIMMLSIQAMEQQFEDYAKKDSIDRSDELDDINDLLRMAELAKHEAKSFSQNTARDKMRKDIQILQSILQRAKAERSEFKKAIKQSEEKLRYEVEKKKEESLKNEIDKEIFTKIIKDDRDRYRQQVVELTERIKKLEKEKYDVFLLAKSNQENCLVEMRKLTRALIKAKKMADDQSHDSKELYEQTVRVKCVMQQLDTSQAEESIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WX60</accession>
    <name>A0A6G0WX60_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">pantothenate kinase</fullName>
            <ecNumber evidence="4">2.7.1.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_010774</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16373"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the type II pantothenate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.33" evidence="4"/>
    <dbReference type="EMBL" id="VJMJ01000137">
        <property type="protein sequence ID" value="KAF0732122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WX60"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021229"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd24122">
        <property type="entry name" value="ASKHA_NBD_PanK-II_Pank1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000025">
        <property type="entry name" value="pantothenate kinase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004567">
        <property type="entry name" value="Type_II_PanK"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00555">
        <property type="entry name" value="panK_eukar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280:SF20">
        <property type="entry name" value="4'-PHOSPHOPANTETHEINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280">
        <property type="entry name" value="PANTOTHENATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03630">
        <property type="entry name" value="Fumble"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0732122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="395" mass="44284" checksum="DFBD68A4A79ADB8F" modified="2020-08-12" version="1">MTTVKFVLAAICVAGLVVLRKRKLRRLHARIIYHRDKDMGYRFGMDVGGTLGKLVYFEKKDGSASDLGDVNSYLVDTEYYGKAVQRDNAMMLDVPGGRIHFLRFETSQVEYIVEFVLHRCFHRDIRTIACTGGGAFKFSKLFEDHLGISLHKCDELECLIRGMVYVMRHVHDECFTFKNVSLHSQGIGEATKKITKIPQSELYPFLLVNIGSGVSILKVTSETEYHRVSGTSLGGGTFLGLCKLLSKYKSFDEALEASVEGNSQTVDMNVGDIYGGNYTQFNLSASTLASSFGKMGTKYEPKSGVRDEDVARSLLIMITTNIGQVAYLSALRSNTQRIYFCGNFLRQNEIASRQLAYAIDYWSKSKMEAQFFHHEGFFGALGALLTNNKELNIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WX70</accession>
    <name>A0A6G0WX70_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Orn/DAP/Arg decarboxylase 2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_010783</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000137">
        <property type="protein sequence ID" value="KAF0732132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WX70"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021222"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008836">
        <property type="term" value="F:diaminopimelate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="entry name" value="Lyase, Ornithine Decarboxylase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43727">
        <property type="entry name" value="DIAMINOPIMELATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43727:SF3">
        <property type="entry name" value="GROUP IV DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="Alanine racemase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 N-terminal" evidence="3">
        <location>
            <begin position="769"/>
            <end position="869"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0732132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1157" mass="124700" checksum="844EAC909B106C11" modified="2020-08-12" version="1">MHQPRVSRTSRKLRESVACHRPELVPLFEVIHKAESPHQPWKIQTPADAVKLSTFLHSKMLLSPELNRNSSCYIARRIVQLYIKLKYIATFPAQEIDDYSSLGDQEYDEVRMVHYLMAHATAAAAVSTASIDLEPIYRLAAMLGISPHSDSWPDVVKFVVSALPFAEHTETLLVRGSDDRSLLDSITKTNKYNTSTIPAALPDHAWISRASCTSSTISLDQFTAAERLRQELLLASLSINHDNIADAFDRKMHSVRLRLAQALGLDNSFEDRAFECIISPSGTDAELLATSAALARMLTLESPSNPRGTVTCVVTAQGETGSGSVNASAGQHFSKITPSGESVDIGKALAGFPSTRVTCVQIPARQTSGHILDADAAATTAVRDALSSNPNNVALLHVVLGSKTGLSCPSLGAVAALTDEFGSRLVVVVDACQMRLDRAALADFLALDYIVLVTGSKFFAGVPFCGSVLVPAQLASEMNAADARICFPPGFGQYFSKHEFPPSSMEHVRETLPARMNVGLLLRWETAVVHMQVYASIPSAIVAQISHDYITRAKAMLLTHAHIQLLDAFDAPAKRARPAPRISSTGLPLQPLDTIISFHIVDANNELLAVSKLKTLHALLAKDLSDCLAADDVALARKKCLVGQPVSLGTLPHGVLRIALGADMVNAIFQGTKTMSELVLEDAIIVRKIQLILVNWAPLVARYVEAPATSTTVPAAPVLTNASPLSPPSSSAMPLLPATNYTAVVRSLVAKFPFVHAAPRTLVYDLDAIDMAFQSLVAPFPPHFEHRFAVSACPFAFFLRRAIENDIGLTCATLVEVQHALRLGCAPHKIVFASPSKSQSDIRQAIDAGVDVTADSFGELDVIRAHAQQRFQSNFPECTPRYAGELPRIGVRVHACRQHDNRAQPPAPWTIGVPLSGENRTKIIQAFVDNPWLSSLQAMSCGPEDFAFAAHVLCDLANEIDAVVGEDRVKVLNLGGANGGCSSPTLGERVDSLHVDAPKVFERHGRTVLIEYGMNVSAKAGWTLFPVEQVRKNHDDAPTAVVVPVDGADLTATLADGTFQHRVSIVKASSEATPSETFQQELVSFSGGKPTVRSIQVPQIESGDFVILHDTGAGTLVPRNCGMPAPAVCGYRKTDDALKIVLLKPAESPEQAMHVWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WXA6</accession>
    <name>A0A6G0WXA6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">IPT/TIG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_010780</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000137">
        <property type="protein sequence ID" value="KAF0732128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021225"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00102">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46104:SF1">
        <property type="entry name" value="GENE 9195-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46104">
        <property type="entry name" value="GENE 9195-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1079"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1116"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1197"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1250"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1276"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1302"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1326"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1470"/>
            <end position="1492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1545"/>
            <end position="1567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1579"/>
            <end position="1601"/>
        </location>
    </feature>
    <feature type="domain" description="IPT/TIG" evidence="3">
        <location>
            <begin position="489"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1386"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1386"/>
            <end position="1415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0732128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1939" mass="218595" checksum="E0FAC3769E3F4C64" modified="2020-08-12" version="1">MYCQKGAATFIPQPKNFSTPQSCFPGFFCPRGSSTPEGQGPCPTGYYCPTPTDAIPCPPGSYCPGVGNTKAQDCYPGTYQPAAAQSNCVLCPVGYICPSYKITQPTICPAGFVCSTFGLSTPVVTCPAGFFCNEGTWTSDPSELTPLRPYPCSPGKFCLGGVEHDLTIDWLPSTPSGATATQTCTEGTFCPKGTVASTLCYPGHFCPPGTEFPLQVPLGTFSQTEGSISPTLCFPGTFSTFKASTECRVCPAGYTCPGYGVYIPAICPPGYYRSIADSITCRLCPEGTWSPDTGLADISYCQPCPNGRVCGFQGMNNLNQSIPCASGYVCGEATTRAMQYYHICPAGYFCGSETTQSEQYDNLCASGNVCYRGTKSTESTRFVCPEGSFCPTGTSDPGVKETQCPLGTTSLAVSNEVIDCSILPVAVCDKSPTDTSYYPTFDYTFQGQTYHYNSKTKIGRTGEIRVLKKILPVNLSASAAPWVNDTIDVLRACPSVVSGSGGTLITVIGRNFLPSNRLTCEFQVKGNTQVFMSLPASYLNSTRITCRTPPFIFSDGSKEGIVNIFVTNYGVHRSATAAHLTYTTKSNIVQVNCGYNPSEEAPRPSELGWFPLRAFSQAFLSFDLRAIPSDLVYDEHFKIAVYVTPSICQDEQCNQRRVLIPDGDDIETTPCRQPLVLPSWITSTEFNQHSIINLTVYALEDMRIKPEIHLMYGIFLAAEDMFSNSTQVDITSPKRANVTQGIVADSRPLSPLISFEQKLVPREYIFVSIYKNEYSLVTPYPLNLPQRLSQLERGRVLFMANVSDDSSQPNILDPPPSLPLNYWDMPFDTLEETIAKTTKYRETFQGLDSLMSFYSMNQVILPYLPFFSHCLTYDSYIPIYDLLENENQCDLPDLTTFDRNWWRRAYPAFPNQDDIRIVGPTDILEEPVADYCVREIKCNYEEDLTTVDINPRWFEAKDATRLFDLLHEPINYAQYLQGGALYDSLLDDANSDIFIPVFVNRKAAEDIEGGCGFRCYPRSVTLKIDYYQVTANLKRIVSASLIFDEFDRDATTTEYTLKVEYAPLDYIELVIHFAFDMQVFIVLFCVMGLSATVITGIFWIITRLTTRIREPPKLRYLSYLALIAPPPTIGIVLASVPCFSVIGIFYMVLNGDKLTNTSGGMPWSPWGNDFWFLDNIKDHYMSAQVDPTMVTTLRHGRVGLCFFMMASFLLYQGTMIFIPKTISISERAAEEKDDDDESPWTPTPWRRSNIILTCIALSIFLVVVIEYSFWTDFAPNLFYTQFSFELVIPILIAILDKTIGDALLFAPMLCVINVIFATIIMAAPDFLGFGIAIFTCFGLILVRRVYKKPTFWAVVHTLKQVVHALKQFTKKMKILMRFYLGRKPKVPREQSEGKNGDKSEDKEKKENESNKKQEEETATVEPIIEFCMDYTMETLSFYFQPIFILLMMIFRDETALSDNWGIRHQDVEFYCLFFAIFIPFQLMADVFILHVIELFRGWKLYDYFVYCRYRFIQREHRWKGMEHNLDECIEPGLRHLDQMCFSSQYYFMCAVQAWGMICLILSIEIMVRNTYNMFGDPAALYLVPFMLSVCIFVRNFCLYIARKFAFYKLRHENTAWHNAPDDDDTGVPDWEELERIKGASHEAFLMNQRLTSETFRFKFLNYNRPWIIAQLPNILTPRTLRRARPYLITQFSKILSSLNPQVSDDDDDVGKPRFGPVSLSAPSRDLIRLWLAKARRRLRLRQAVQPLINAARKVECESCLSRRQLQVEMVIPIEVLGDKFERSYPSDEFDVAEWKKYFAQHQKFKTLCLSCLAKQKQQIRMPALGAGANNADDAEAAATLGFGSVHLNAASRALMMKWYRLGQDRVFGKTGKRRVVANISDDEDEIALRGAAWANRPLNLNAASTAIALKWMVAARLSIKARIQGKKVQPLEAAAKPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WXC6</accession>
    <name>A0A6G0WXC6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_010803</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000137">
        <property type="protein sequence ID" value="KAF0732153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WXC6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001095"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000015">
        <property type="entry name" value="lymphoid-specific helicase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="165"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="493"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0732153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="720" mass="81457" checksum="9628326C8A6C8A22" modified="2020-08-12" version="1">MAPSMETLPAEVILDEENDCLVEEKDAPVVVEEGIVDDKLKQVEDELKLEREQHDGSEDESFKSISYSKRVEKLDSLLEKAGAYSKFLMSNMEPVAIEPEVVESTPSKKRKGRPGKVKDGASKLQKINENQAAAHSVSEMKFKQPSLFTGGTLRSYQLEGIQWMCNLFENGLNGILADEMGLGKTVQVIGMLAQLKAKGVRGPYLVVAPLSTLSNWYNEFKKFTPTIPAIIYHGNNHERKQIRMHQLKRGTQSNPDFPVIITSYEVIIRDASSFNAMGYTWKFMIIDEGHRLKNMNCLLMKELKKCRSENRLLLSGTPLQNNLSELWSLLNFLLPDVFDDLALFQSWFNSTSSASSNTTTDIISKKEVLTNQKQNQVVSKLHEILRPFVLRRLKTEVVMDVPSKTEIVVYCPMSDLQASYYKLIAEKKLAKALQEKYGKTTSMPSTLRNMAMQLRKCCNHPYMFDEDTDASGNVVTGEHLVQAAGKLQVMDSMLKQLLKKGHKVLIFSQMTRVLDILEDFMLLRRYQYCRLDGQTHFTERQRSMDAFNDPNGGLQIFLLSTRAGGLGINLTGADTVILYDSDWNPHQDNQAQDRCHRIGQTKDVVVYRLITENSFENRMLQRANAKRTLERVVLSRGEFSSASGGSRQANLTMEELESLLQDDIQIRQEATGGISEDELAFICDREQVTEAFVKKASDVPKESKGYYVVDSSASKMESFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WXJ2</accession>
    <name>A0A6G0WXJ2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_010588</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000135">
        <property type="protein sequence ID" value="KAF0732299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WXJ2"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0732299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="75" mass="8812" checksum="417011EF6BC4F08F" modified="2020-08-12" version="1">METIVRRRLFTEKEDFMLLRHINAERPFEASKGDLIKAWGRLATKLASHEEFSRPFGITGRSIYEAAHSSKYTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WXS9</accession>
    <name>A0A6G0WXS9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_010600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000135">
        <property type="protein sequence ID" value="KAF0732311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WXS9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014545"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000075">
        <property type="entry name" value="Protein phosphatase 2C, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="6">
        <location>
            <begin position="23"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0732311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="340" mass="36931" checksum="F72464E4718C21F7" modified="2020-08-12" version="1">MGNFLSTPRTDKETYVGEGNGISYGVSSMQGWRSSMEDTHVAQTEIPGFKGCSIFAVFDGHGGKLVAQESAQRLVDTLTTTLDDTKSPMAIGDALERTYFKIDDDLRELDRIDLGEDQSGCTAIAAFISDRHVIVANTGDSRGVLATAGNTVIPMSMDHKPNNPTERSRIEKAGGVVRNNRVNGDLAVSRALGDFYFKERSDLSPEEQEVSAEPDIKVQDRSADNEFLLLACDGVWDAMSNEEACSYVRSLMARGESNLGLICEEVLDHCLSLGSRDNMSIVLIKFAGAKIGSGDGVMGLRKERAEAEQIKRQEELMRQDALRQAPPAIPSNAFAIVGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WYH3</accession>
    <name>A0A6G0WYH3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_010310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000130">
        <property type="protein sequence ID" value="KAF0732602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WYH3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004486"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052050">
        <property type="entry name" value="SecEffector_AnkRepeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586:SF3">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0732602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="397" mass="45094" checksum="19F27094CCCAC75A" modified="2020-08-12" version="1">MAKKRRGAETISVVRRVLCSSDLVALITQFQHGIDHDMRPFLSLYRQRWHLTSMLDYPSRYRHIHAVYEAWQAEHTLDDVPRLLECLPFVRNSLAILAMRCERRDLATLIDLSLCRADVIEFGVLVSGHLGNVAMVELFFPFLQTAWDPEGEDYIARGGHIPVLRSLSAQPNVIFTTRSMDAAVQANHFPLVKWLHRNRTEGCTPKAMNAAAANGHVELVKWLHKNRREGCTTAAMDAASAKGHLEIVHFLHFHRHEGCTTSAMDSAARNGHFEVVKFLHNYRWEGCTTKAMDEAAARGNLKLVAWLHANRPEGCTTRAMDSAARFGHLHVVEWLDANRSEGCTSKAMQDASRYGHKQVVAWLHLNREKIYVTRDAAVRRSLATRRSKYIDLTEEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WZ94</accession>
    <name>A0A6G0WZ94_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_010172</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000128">
        <property type="protein sequence ID" value="KAF0732843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WZ94"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018692"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0732843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="293" mass="31478" checksum="9883949B20B7C7F8" modified="2020-08-12" version="1">MVAQDPVYTARSLGQQSTVNSSVLAQSDMPMLGRRSGFHHRRLTTQKRCATFSLVLLTIVAVVVLLTMSIPKSSHSELMSSNRQDSTTTVAPRPNPTALLYSQAAPSTSPESNDMDISAILAPIATAAPTTTKPRTSAVTTQAPQGTPTPKPSTRPPTTVATPTTSKPPQPTTTAQLTPKPETAAKGNEWTSAPSETPRRTVPNATSSAPRPTVTSSTPSTWTDTPTIWTPDPTEDPDGTPSTATTETPPEPKETPQFNEGTTTSSPTLLEKIQRLHRCRYRRRRHVEPCSPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X174</accession>
    <name>A0A6G0X174_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb/SANT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_009785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000122">
        <property type="protein sequence ID" value="KAF0733551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X174"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019141"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0733551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="33882" checksum="193E0E627D47D17B" modified="2020-08-12" version="1">MTPAPTEEKPSKRRGRPVKDEEDDDPDQKRPRGRPRKSDKPSATWCNQSVRLLFQLRFDTELRKKFDERDNRAKRAGYEMLASKLSEQMSRKYDNAQVQQKLSQLHTVWTKYKPQEDESATNQPAYYDLMVKYWGDQSIHQQGAKVAKKELTNPPVPAALPTPLGVGLIGRPPTVAAVSTTPTGTQTKLRRILSKQIEADEAIPAATSVPPMSTETPARSQTPPAIPLGTAFPAQASQRGSSDFDNIAAALKDGIVAFSNSFVRSSTSLAASASRDDKIDAMIESNTKLAAKIDKLISVLSSRYNVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X2Y5</accession>
    <name>A0A6G0X2Y5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_009088</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000117">
        <property type="protein sequence ID" value="KAF0734227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X2Y5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020309"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040283">
        <property type="entry name" value="DDB_G0292058-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31414">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN DDB_G0292058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31414:SF18">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026263974" evidence="2">
        <location>
            <begin position="26"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="454"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="490"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="785"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0734227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="851" mass="91294" checksum="A9FBDE2D12861A22" modified="2020-08-12" version="1">MAVSWKFSTMLRGLLLSTLATVAWGQTPSWPPSGQCSANGTAFWSAQCPSLTTNVVPITVTQYAAGSFANVNLSSLTTIDEARAVLQGASAVKAMSGLRSESTDYYNSSLTNIMITFCYYTSTADDLARCVPASSPYAQKNKGNNSNTCMNVTGNGSCVAQGLCERLPNCMWPRADPTQPRLPRFTDDQINAARDWVTTSYAKSLAPYAGPGIAFAVLTFLGFGAFFILRCFCNRCGGRDPAERGYTWCGVMTPGIAFFIFSIVIFICSVAAYVQNNTVTARFHDLLSVLTDTINNLNANSNNWLAPLRSIQDLQATSTAKVQSVLADTTWVTSSAAKLKALGDSFDTYYSSGFPQTCVQNGAVCLTCPSSICGGSTATPKAVLSDWNSMATQLEKTFQLTRDAMYSGTTTIFSAANDAEDALTAVAAATANSGSTVSQVQTTFDSISYARTGLVLSIFILGLFVAFLGMAGFLKGICKDKSKWIHLLHVSWGLGVILCIISFVVASCLVAVSAVWFDGCQYLDMVMNDMTPYFSAETSRVVGACIHSTSVLTAIGMASAYGTSCEIAERYRTAQKLGMMTRFQSLNQLGMEILSYNESLFGWDSQVHYGLVSTAATAMSSDMNKMGDFSVLEKPWTLYGEQSAGGSCTSDADPPKCYMKTKCSTSTSATCYSAFTDAIDYTRARNSIRSKLQTMRQDFIGDVGFSNSPGWPGGDASISSIARAYAQKLETFVTTTITPVASLGVWNQVNALQCTSASGCGWINEEYAMVHSLLCQDLLGACLNIALSVFMNALFLLPMAICGIVLQKRLRAIRGGTYGAMEPPAPGVELTGRQKLEKKLEALTKGQMTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X436</accession>
    <name>A0A6G0X436_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">UmuC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ae201684_008669</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000107">
        <property type="protein sequence ID" value="KAF0734711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X436"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019012"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009314">
        <property type="term" value="P:response to radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.60:FF:000003">
        <property type="entry name" value="DNA polymerase eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052230">
        <property type="entry name" value="DNA_polymerase_eta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041298">
        <property type="entry name" value="UBZ3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45873">
        <property type="entry name" value="DNA POLYMERASE ETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45873:SF1">
        <property type="entry name" value="DNA POLYMERASE ETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21704">
        <property type="entry name" value="POLH-Rev1_HhH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18439">
        <property type="entry name" value="zf_UBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036603">
        <property type="entry name" value="DPol_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51907">
        <property type="entry name" value="ZF_UBZ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UmuC" evidence="12">
        <location>
            <begin position="13"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="UBZ3-type" evidence="13">
        <location>
            <begin position="469"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="501"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF0734711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="523" mass="58688" checksum="E5E2C297E1C43E8E" modified="2020-08-12" version="1">MQDERNAATERVILHLDLDCFYAQVEHERLNIPQDQPLAVQQWGSLLAVNYVARAFDVKRSENIGDARKKCPQIHLPHVETLGEGSEVAPNRSKQKAILRRYRVASRQVFLVIAKHVPLYEKASIDEAYMDVTQQAIDRLDSGASDGMEYGQTHVYGIEGGAFPHTRQEKLLCIGAQIAQEIRDDIQQTLHFTTSVGIATNKLLSKLASPLHKPNGQTLIPPRSVQDFMQTFRVDKIRGLGGKLGARIVELSTKLDKETSRVTAGEIVDEFGLAGLQQQLGVETGIHVYNLCQGFDGNEPVNPKKTLVAHINSVKSFEKTGILKSDDMLRYWLRILCEEMVTRFDEEREENQRIPTQLTIHYERPGHKKQFKHFAVPHKIDTESFFAAALAQIEISTALPCSLLYLVGKDFVPISSGAAKITQFFKGVSAAPIQPKEEVSPAPLPSRHINKTTPNASIARFFSNNPTSEDDGRYFCVKCGRHIDSTAAEHDDYHMALELSSQWNEPTPPKKRPKGPMDFFVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X567</accession>
    <name>A0A6G0X567_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Fanconi anemia group M protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Ae201684_008337</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000101">
        <property type="protein sequence ID" value="KAF0735125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001016"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18033">
        <property type="entry name" value="DEXDc_FANCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15571">
        <property type="entry name" value="ePHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12091">
        <property type="entry name" value="FANCM_ID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15492">
        <property type="entry name" value="PHD_BRPF_JADE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18801">
        <property type="entry name" value="SF2_C_FANCM_Hef"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02249">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000861">
        <property type="entry name" value="Fanconi anemia, complementation group M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1320.20">
        <property type="entry name" value="hef helicase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039686">
        <property type="entry name" value="FANCM/Mph1-like_ID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044749">
        <property type="entry name" value="FANCM_DEXDc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025">
        <property type="entry name" value="FANCONI ANEMIA GROUP M FANCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025:SF20">
        <property type="entry name" value="FANCONI ANEMIA GROUP M PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13831">
        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="49"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="381"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="13">
        <location>
            <begin position="1151"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="17">
        <location>
            <begin position="1204"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="14">
        <location>
            <begin position="1458"/>
            <end position="1512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="778"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="898"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1050"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1104"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1331"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1525"/>
            <end position="1614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="778"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="814"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="827"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1125"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1340"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1371"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1394"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1536"/>
            <end position="1551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1565"/>
            <end position="1590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="1593"/>
            <end position="1605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF0735125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1891" mass="209954" checksum="7FC47C7985326659" modified="2020-08-12" version="1">MAQNTLAFAPNPLEIPEDSVVMGAEIDRDLATQWIYPSNYPVRIYQQTIARAALFQNTLVCLPTGLGKTLIAAVVMYNFYRWFPRGKIVFMAPTKPLVSQQIQACHDVMPIPQHDMAELQGNVAPAKRKLLWSTKRVFFCTPQSLQNDIERGNCDVRSFVCVVVDEAHRATGNYAYVVAIRHIAAKISGFRILALSATPGSKFDVIQEVITNLRISHIECKSGDDPDVRKYTHSRQEEIIKCKMNTEVTGVKAQYLKLFQPILHRLCSSQVLHIRDPEKLNRWIVVTSRDKMRANPQGNTKPYRTVEADLALLISLIHGRDVLNVHGIGNFKTFLENFQAESPSGPKKLLLGSPEYAQLVQLVETQAAGGRSAANNPKLVQLQQVLSEHFNRHVQGGSSTRSIVFTQYRESVSEIVALLSSMEPLIKVKPFIGQGSSKGKDGQTQKQQQEIVTKFRQGEFNVLVATCIAEEGLDIGEVDLIVSFDCLTSPVRMIQRMGRTGRKRVGRVVLLVTEGDEEKKLERSVAAAKSVNRSLTIFKDKFKCVPSARMVPSGIIPKVTESAMVVPTFQASRIGGKKAAPRIEVNDIWQLNDDENHLLKLKHPESFKRRAHLFSVMLPLRLSTFSKPHHFGRTRRSRCLLQLMHRIHDDCMSNADFYRLYKEATTKVVNEAAVEPTLIRDEVVEVETQPVHLSIPEDEFTHSFPMTYDDGDTVSPMANVDNRLGTASPTKEAPKEMTQNEVHENIIEIPSSPEEDVIPTRREAAAVSNQTTIYSLFASNRSGGSDNLSSPRTKLSSPAKSIASSARRQSSPGTRKKSPAKRTRSPIKATSTKLSKAKASLKAIASNKSATNHQPSTKEKKDDVNASPMNFSLDTSLGVMEQGEQVIAMLEYLSTRQLTSPETSQPKTPRLSPQRTSSLTPVRAFPRVFRPETYSDDRPVINDIVVPKAPTWNDVFHQDNEGKASAQEKEPSSYFTPRAADIKRTSDFTADSPLFTTTQPSPEVSMAPTNLVEAERQDQSITSFVSPLSTPNTSVKQQDLNVNVAKAETRMLKSPTSKPPLAKTSHKSPITPQTPNLAAQKALSFGSKDVQAAKSKKRSLLALPPDDFIDATPSPLPRPGRQHNLIDSSSETQATPSLSSQRRRRLGTPSNDVCVVCSDEVSTETDPILYCDGCDIAVHQHCYGVPVIPDEDWFCDACRDKSKPNSCVLCPIRKGALKKTSCNQWVHIQCFLWIPELVVKVNGASIQLGSLETLDAERFTLKCEVCGTAQGCGIVQCAVRSCFRAFHVSCAATAKYKLIEREGVECTQFVIYCPAHLSVALNARERILSPGETLATPKPDKKRKRLKKTGSPRRNGKRKASKRLISHYIEMEADADEDGSPDEDEDDEHGGHALNSSFIDDESPSQYVSPATMQAIFRRRASNSPLVSKYLPSQGIVAACLQGASSDMDRSFEIDILHHGFACNECKLDPIEGVRYSCERCANYNLCTCCYSAREEFHPRNHTFMTVHEPTESPAATRAPRPIAHAAPAMPQPPRNQEKAVVHPAAHEINPRKPSTTELTADQVARMEESRRKALELQRKRMQDSSRLAKPEQSPPPPVLPPPLLPQAAPTPSFDLLKPTNQTSMSIAGINTTAMASMPPVGGLSLVPDTEEMPSFSLLPSFNLMPSVKAATPPTTSLGYSICYRPQIKSHPLLVDLFRHDALRKVAEPTLECDVLLSARCAVFVLSWMEFQKIVQSVQNPHLTWLGVYGRLIYIVETSPPTSRQMTEECAAYVAKFTGMEILWPDDGADTLRQVLDMAGKEANDGFGLVQYDPGKCEKDKKFIERWTLFHSVPLLSYGGQQALSKRFTNMSAAQIIQMNTKFNPMHWKRMLPWISDAVAQSVHQYVKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X5A2</accession>
    <name>A0A6G0X5A2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_008348</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000101">
        <property type="protein sequence ID" value="KAF0735136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X5A2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010339"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0735136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="109" mass="12820" checksum="C27EA7768BAB6661" modified="2020-08-12" version="1">MGWIRHLNFFADRRRKVTFVQQSIDPPRNKPTVNPSCSQMRLMQYSVVKLPRQPRVVVPVRIPLDYVYQRLTTVGGSRVPFTRRQVKIAREKMSLCDAIHEHDDIIAFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X708</accession>
    <name>A0A6G0X708_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BD-FAE-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_007728</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000093">
        <property type="protein sequence ID" value="KAF0735718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X708"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004468"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049492">
        <property type="entry name" value="BD-FAE-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF33">
        <property type="entry name" value="KYNURENINE FORMAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20434">
        <property type="entry name" value="BD-FAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BD-FAE-like" evidence="2">
        <location>
            <begin position="137"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0735718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="398" mass="44021" checksum="F7BDCC2A27C0D443" modified="2020-08-12" version="1">MFRDTLNNLRDDHITESNLAWIETREIELFGASAMRFGHPTMQRFCLRCGLGQLGNIGNKFKVFKAFRSSHVYAAVVWLGNAGNVFFGLSAPKLAMRTLARALRFSTTNFRYGPHERQVLDLYGTTSTDTVSSLSLKPVLIFVHGGAWALSSKFDHATLGETLAEHDIVTVIPSYRTFPHGEVDDMIDDLRDVIAWTIENIASHGGDPKRISLAGHSSGAHLTSLLLVRSAFQDSLFPDPVEPVHHVKSFIGLCGPYDITDHYEFERDRHIIPFVRAHGISPLHPSCHGRHQFPKYSPTAAVLNLATTGSAWKLPSFHLFHGADDVVVPSQATHKFAKHLKQVGATVHVHNVPFGHVEILLALMGGFPQLEKTMMDAVVPVIKQTADAVVTWSGQSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X786</accession>
    <name>A0A6G0X786_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elicitin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_007760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000093">
        <property type="protein sequence ID" value="KAF0735754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X786"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014481"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026161126" description="Elicitin-like protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0735754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="18825" checksum="83212474052991C9" modified="2020-08-12" version="1">MNRIAFLVLAASVAQGIDLRPPCDRSVLLEAPGKRLWATCASKTGLDIDSILVPSNEAKLCSVPECVYVVQKAAVLTTCDDAALFAQLCKSNATASLPTVSPTTTNPSTVTTTTSPATTAATPAQTTSQPTTSLPPTDSTTTVSPESTPIPTAAAVAPTTSQANPNGANTFAAAGIAAVAIISAIVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X9A3</accession>
    <name>A0A6G0X9A3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_007523</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X9A3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020089"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36234">
        <property type="entry name" value="LYSYL ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36234:SF5">
        <property type="entry name" value="LYSYL ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14295">
        <property type="entry name" value="PAN_4"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13365">
        <property type="entry name" value="Trypsin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026044847" description="Apple domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="4">
        <location>
            <begin position="719"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="4">
        <location>
            <begin position="804"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="4">
        <location>
            <begin position="878"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="365"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="367"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="640"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="662"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0736513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="938" mass="95471" checksum="B525B50B72D1088E" modified="2020-08-12" version="1">MLAAVICALAAVVSVLASQSPVQLSRTTYSVQGAADTAFSTVIAKSGATFVSLHFASLALPDGARLAIVGGDSTTSPVVYTSANNRANFSSEAILSANVTLQYTPPATASPKTPAFVVDSVVFGKQVPQIESICGADNSVGSACAPSFATIGLPVARLFIGGDEICTGWLWGSQGHLLTNNHCIPDAAAAGDIQVELQADCATCDDPKNTAQLGCKGTVVATSVTFIKTSPTLDYTLVKLNLVNGVSLAKYGYLRAREAAPVLKEPVFLIGYPKGWPKHVAAQLDDSSAGVLTQVDVTSGCGNAKSVSYMLDTQGGSSGSPVISSVDNLVVALHNCGGCANSGILMSAIVQDLKASNIQCPVDGIVPSSPSTTTATPSTTTNSPTTTIQAPTTSTVVPSTTTSAPTTTSSTPLVTTKTPTLTTTESPATTAQTPRVTTLSPTTTTTPLATSSDNPTLPPTTTNSPATTTQTPITTTKTPSTTTSPPATTSKAPTTTSPSTTTSSPTTTSKAPTTTSPSTTTSSPTTTSSPTTTNSPTTTSKAPTTTSSPTTTNSPTTTSKAPTTTSPSTTTSSPATSTPIPSTTTKSTSTKPPLSTTPSSPCTTTKSPSTSTASPSTTTTSPYTTPSPTTTLVPRSTIVAPSTTASPATTLKSPCTTPISHSTTTKSPATTSQTTTTTAPATSTKSPVTTTRSPATTTAAPCATKSAGHKGYNAIEDNADYVGHDVKATLRASADLCFHDCEATEGCQLFVWTSFNGGTCWLKSTSGFKTFALGAKSSTKKTSSAATTDAPSFPATYNPIQDNVDYPGFDIKGTSRGSPDLCVADCDATDGCVLFVWTDYNGGTCWLKHTVGVKSIVAGARASTKKAAMCGRVETGMDYPGSDIASVRRATPAHCCDDCKATKDCKLFVWTDFEGGTCWLKSARGSARAYTSAVAVAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X9P5</accession>
    <name>A0A6G0X9P5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein 70</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_007138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000088">
        <property type="protein sequence ID" value="KAF0736691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X9P5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016940"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009724">
        <property type="entry name" value="TMEM70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045325">
        <property type="entry name" value="TMEM70/TMEM186/TMEM223"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13281">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 70, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13281:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 70, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06979">
        <property type="entry name" value="TMEM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0736691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="22525" checksum="C674339498CD5E83" modified="2020-08-12" version="1">MLRRIVRVKLPTAHAPKATWKAMAGRFYATEASEESTPEKELIYEAPLAKPVRMMKAVSITSCTLTSIGMPITCVYGATTSSVIAQWAMCGTVMIFGMGTTAAFHVLFKPYVLRMWIDRASEKITVETLNLLAAKTTSEFNLSDATFPDKSMHPMINFKAAGKHYFVHPEAFDESDRNVVERLLGRPLDELVKKDDEANESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XA01</accession>
    <name>A0A6G0XA01_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_006960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000087">
        <property type="protein sequence ID" value="KAF0736803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XA01"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016452"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169:SF2">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0736803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="145" mass="16219" checksum="157E13528F4B0221" modified="2020-08-12" version="1">MMEIIDAVNSAWRDVEARTLNNNFLTLQACLQEVLKIEGDNKYKIPHMRKSSFLACGMLPEVLPCDTTEFNRCCDLLDGVDIEERFQVLAEEVKNDLDMSEICTALEGIGVGGLDMESCGEDVDEVESDGENLEFIPRILGLKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XA04</accession>
    <name>A0A6G0XA04_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">E2F/DP family winged-helix DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_007179</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the E2F/DP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000088">
        <property type="protein sequence ID" value="KAF0736733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XA04"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010822"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003316">
        <property type="entry name" value="E2F_WHTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02319">
        <property type="entry name" value="WHD_E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="E2F/DP family winged-helix DNA-binding" evidence="3">
        <location>
            <begin position="4"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0736733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="316" mass="35267" checksum="61F297E54569DFE3" modified="2020-08-12" version="1">MVLRANYLETALSLPRRRIYDVFHILQAIGLIRKGGKLVDGKKGYIYNGGDQVATTFASMQRFVNDQQRKHARDRRLKTTATILSSVLIDVQKKVDQQGDKSKVPALWSATQRLLMSMVAHGNSMTQRDIYKLDDDSDGTSTKSRRIYDVLAVLSTCNMIEFDTDAKFDRAKSVHLNPAMLNDTRHFSIFDKIHECDGLPRTKSEESPESPTSAKRSASCNKDQNTCFSFDYQDGDGQAGGTSTPHESFAGFIHDSMFSTESLDLQSIDCLGHVCCPSGSKLILSPFKLALAEDESSEACFAWFPLHEFELGELDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XEI5</accession>
    <name>A0A6G0XEI5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_005530</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000071">
        <property type="protein sequence ID" value="KAF0738602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XEI5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006912"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000002">
        <property type="entry name" value="Transmembrane protease serine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF91">
        <property type="entry name" value="AT26814P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026140949" description="Peptidase S1 domain-containing protein" evidence="5">
        <location>
            <begin position="17"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="6">
        <location>
            <begin position="21"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0738602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="307" mass="32242" checksum="9CCE18F8D4304496" modified="2020-08-12" version="1">MKLVYALTALAAPVAAQGIEIVGGTEAAIGQHLYLSSLRKTTDGETQCGGSLIAPNVILTAAHCSVLTNYGLKYAVVGTQYNGGTQYGETIAIKQQIVHPKYDKNSNTYDFAIYILASNSKQTPVKVSFDTVGANVPVVVRGWGAIREKGPEPDVLLELGINTLDNARCANLLSGYNVDSTMICAGGQAGKDSCQGDSGGPLTLESSGQESLVGVVSWGIGCAQANQPGVYSRISAARDFIEPYISSSPTVAPSTKPTPVVPTTTKPSVCGTCNYCYYPAGVRCLTTFTKSDCSYYNANYGTIWCGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XER6</accession>
    <name>A0A6G0XER6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_005588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000071">
        <property type="protein sequence ID" value="KAF0738661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XER6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012124"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052050">
        <property type="entry name" value="SecEffector_AnkRepeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586:SF3">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026210970" evidence="1">
        <location>
            <begin position="20"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0738661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="299" mass="33642" checksum="D9D1E6E722F94076" modified="2020-08-12" version="1">MPRLCTIFFLPELWHVIASFQNGRQCILLPFLGIKSPSETTCQTWVLDLQSKLDPWYAEYGTACVLQLVEHLPKMKDYLFMAAVAANDVPLLKVLDELLNLMSCGRKLLNHASQYGSLEALVCLHELGHPGCGQSAMEMAAKNGHLDVIQFLHANRTEGCTVRAMDVAAEHGHLDVVKWLDGNRSEGCSNYAMDHAARNGHLQVVQWLHAREYDCSPFTMVYAITGGNLSVVQWIHENRREGCVSVGINKGTPKELVEWLIVNRSDVDPERILKDAARSKRIDLMELLMDRFGVTWRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XF15</accession>
    <name>A0A6G0XF15_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_005389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000070">
        <property type="protein sequence ID" value="KAF0738777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XF15"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017542"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0738777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="241" mass="25684" checksum="5DA5D3B1CE29628A" modified="2020-08-12" version="1">MFALRVGESKGSLVRTLVGRSLHSSGHAMHNLPTIKLNGKNLSIRVAAMGALGLACASSCTHAHSQGKMDLTAPIKGTAGSGSSKKNARDGTGDDPSSDSMVKFFCGATAGAVTTLAVKTAAWFAVGVAACVQGAMLLGLADWKHVEETGKNVWKELKRTFDGSYISRSDGQVNWKKLGKDFMSGRLDWSKLEEDVNALGGKKDDLHDIRRAFEEFQVWATKTVYSVEFVFGAALGVALMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XH22</accession>
    <name>A0A6G0XH22_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_004738</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000063">
        <property type="protein sequence ID" value="KAF0739557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XH22"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016987"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23011">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23011:SF28">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026284678" description="Cyclic nucleotide-binding domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="4">
        <location>
            <begin position="356"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="4">
        <location>
            <begin position="513"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="737"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="737"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="749"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0739557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="963" mass="108034" checksum="4D24B074844D8B09" modified="2020-08-12" version="1">MHRRIYIFALLAAVIQAATTLYKHDGVTTYCWTLNQSIADTKLVESNVVGQGSGSQCLAAMTLDFDGSTSTHPFSNVSAAWTISILSRETSLATAKVGAQTVEIVHANVHTCVYGAVGCDLFNSHGIPLSSTSPQSGNFSIFRQAAFHDSWQYLEPGTYSVFAHITLSTALSPSQRYDLVVFRKLDVAASLPVLSSPPSSSHIALIVVLVSSILVVICMAIVYLHCQRRRSANRFMTIHQVQDDNTIASWSKNYNELAAFCNDDFMTGTPVAAPATPEEKKQHIHQSEAATAHAIQSVGIQKHHRHHHHHHHHYHEGDVDTHLIHKILSKRPEVRTVDDVDKLFMWVTKNNSTSKLFAGIQDVICKNICREMTLLIAPPNTVVCYQGDFGDVVYIILAGQVALYVNEYMQQKPFEDDLHRFLDKTAGVDGQEVAHETFRPHHFGKFVAHVGAGNTVGELAVMELNTQRTCTVVSTMMTSFICLKRGAYQRLARAGNGDLIGFTPFEFIKDLFLFESWNHAQVQNLSAKLRQVTIPADSFVLRHGNEANSLFFICSGVVQETVPMLCLMDENGIAIKYLPVEDKSSKKAKPITKVDRQGTPLSELKRKRVSIEIALFEAHDVCGEQAIVCNQTHSKVDLRAVTDVKALAMDVYLMIQSILISLALSDAIVEALELFKQLAQTRDRWRETRTAIAVSHPRLLFTISTRAMMKHARILCGWCGSHDHTTGDSRCGRVSAARRKAEQRKRQHAMSEKQKRLMAEERRRAAMAPKSNSSEKTPQMRFRVAARAIVSTVQINQAAAALLTPHEQILKDWQVAAKNQARICDGKDLVPEEVERKAKSPLRLIPRKPMVHGESKPVALSLPDAMQNPMAKDKLTSEFRRHLVTRVKKAQTVADYRDLRAHVLDTMVSPEPQMDVPRRPKVPKNRRVRQNRIFRRVDRMLKKLWPTEQTNIEESLRDFHIAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XHC0</accession>
    <name>A0A6G0XHC0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_004773</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000063">
        <property type="protein sequence ID" value="KAF0739594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XHC0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012932"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0739594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="409" mass="46396" checksum="2B72D119F9559F09" modified="2020-08-12" version="1">MSDASVVHGCVAMMMDDIPPPLDFFLPDIDESLFDEASSFEAPAGKVPVPPRNRSNKILVDLAMLHNEAYDLTCLLENLKNERKNRAKEMPRGKWAQVARNQLTLKLRAMRENEELKTMLKDQTAWRQQLEYLLLRKPRATMNRMTDERWRMLHLSSIHDERLEAIHAIANRQFDQMESDMVVAGLLDATDEIDEFRSQVMPMQLHGEAIRFTTLDGPQYAVAEALWSTIQNIGRRPQTAKLSYKCEVEAIDINTLYLRQRVGTVDGAFRLEAGVVIKRFVVNQKTCIVWRTVLVDDAKPFSSNSSISNFYGWIDVEPTSGNSQTTSYKAFCNVQVNDLTHSEHLGLVLQRMSGVSNDAKVDSLTILKESFVRGFGLFERDARASLKRLAVQSPMAWQAMSPPLVACEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XHG6</accession>
    <name>A0A6G0XHG6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_004713</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000063">
        <property type="protein sequence ID" value="KAF0739531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XHG6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010557"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0739531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="117" mass="13288" checksum="EE94CF13EE1858E5" modified="2020-08-12" version="1">MSDDELYNPTYQVAQPVCTTESHGYDEFIVLCVVSLLDSDSEDEDRRDEVMPIKRRKVVVPPSSNDVVVVPDVEDDKDHPVFVLESSDDEVDGGNDVAIRKQLDQDPVLRRTQELLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XHI4</accession>
    <name>A0A6G0XHI4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sphingomyelin synthase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_004854</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingomyelin synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000063">
        <property type="protein sequence ID" value="KAF0739686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XHI4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005377"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047493">
        <property type="term" value="F:ceramide cholinephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033188">
        <property type="term" value="F:sphingomyelin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045221">
        <property type="entry name" value="Sphingomyelin_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025749">
        <property type="entry name" value="Sphingomyelin_synth-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21290:SF62">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL:CERAMIDE INOSITOLPHOSPHOTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21290">
        <property type="entry name" value="SPHINGOMYELIN SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14360">
        <property type="entry name" value="PAP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Sphingomyelin synthase-like" evidence="11">
        <location>
            <begin position="196"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0739686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="322" mass="36187" checksum="65F4950A229854F5" modified="2020-08-12" version="1">MAWSLKLRSWNELVEYTIFELKICLVEWKALLFGIAWQYIHSIFHNLAYWMQTKLSPAQRVPLYDQGFELLPEFTEAQSHISEYLVFGGIFGPVILLFVSVLFIKPSPNSRPRYLALIAKRVLLQTAICLMLRCISFLVTSLPGAAPHCRPMYNQTCLDANPNDPAAEFICSIPNPDFDPPMTVGKVFGHIDALNGCGDLMFSSHTTYTMSLILGVWKYWRNVPLLLLMLAVQVAIAFCIVASRKHYSLDVITALYVVPMVWFIQDAYINDLNHKDAEATPEAIKAVYGLDVPNAEKSASQGTLVQSDQEGVFQSSETPTQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XIB1</accession>
    <name>A0A6G0XIB1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_004461</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000055">
        <property type="protein sequence ID" value="KAF0740017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XIB1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019097"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="entry name" value="Sodium:dicarboxylate symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42865">
        <property type="entry name" value="PROTON/GLUTAMATE-ASPARTATE SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42865:SF7">
        <property type="entry name" value="PROTON_GLUTAMATE-ASPARTATE SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00173">
        <property type="entry name" value="EDTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="Proton glutamate symport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0769">Symport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="345"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="458"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0740017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="545" mass="58036" checksum="04DEA6FCB367B984" modified="2020-08-12" version="1">MQHKSASSGILLYETTASTFRTPSGSPEIRTDFTQEARRPRLPTVKAESVGSDRDYPILDDHPATTMDVRPSIVSSCAILAGAFVGVGVGLALYFLHVGPEWLKLVGLPGSLFIRALQCLVVPLVFCVTAVVVAQMAAIGRSTILRWQTILPFALTSILAAAQGFGLALAFKSWFQTSAGSYATTSTASASPFNLTMQCANGLYLVATNGSLSCAGSGSDAAALFAATNQTQTTANTSLDVGNLIALLVQLGNILVPVNIFTSFTNGAMLSIVVFAVVLGVAAVSITTTADEPNHILDLLRQFRDLFSRMLHALLFLTPAAVAFLLASSIANFDKHYSEDTVAQLGILFVALSIGMLCHSLIVLPLIVLVATRCNPFPYFQHCIPAYLFAFGSASSLATLPVAIECIERAKIGRSIAHIAMPFGAPLNLNGAALYYPLAMVYLTNLAGLGDEWTPSRYVVLFLAGWIGCAATAPVPGGAITYLVSLWKMCFPEMPTHFSFAALIAADFIFDRMCTVVNLHANIAVTRILADQVDETFEVQAAHHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XID5</accession>
    <name>A0A6G0XID5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_004550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000056">
        <property type="protein sequence ID" value="KAF0739969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XID5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006297"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0739969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="343" mass="39366" checksum="524F8EBC76288808" modified="2020-08-12" version="1">MERYFRYEAAGDQFAGRVVCGLPVNSANFAILPPHFPNLDDPILLSALEMSFPTLVKLPNLHGVLCLVLASLVYHFEHLHSKMPINHPLHSTPIFVHADIRIYLLSILESGTDSCYLRASGVPPHIELYKKLDQTQSSISTLPRLIVNELREIIEQNGVMAGNITQGFLETTISKAIADIVGRTGIQNNTQSSCAAESSIEHQIYYWGDGMHLLPESFKFPSVEISVAWKLWWRGNPTEKILPYRKIKTIDLADKKQRNIFYDWKFIMEKLYNYYKRETGLELASTPTEIELIRSFQVVQTMLLPTQKETPQKRQRHDSQLATLTVVRHFREHQKQNLSRTHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJ23</accession>
    <name>A0A6G0XJ23_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_004267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000053">
        <property type="protein sequence ID" value="KAF0740266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJ23"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019941"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0740266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="270" mass="30186" checksum="2ADC742CD1B17D6E" modified="2020-08-12" version="1">MLGMRYHHSEEQSSKSTDDNDATHNSIQSMSQSSLSRSSQQSSMTSVVPFKLPRRLPQFKKAKSLSNLLTTSTKTCSSRPPTMTSIKTPKTPKPAPAKISTFKNAVRLHVGSTIAPSSFLEHLNSPERRLQRPEMAVCSKQHLRSQRIVPRERMPWMREETANDTTFKSCAMAKIASMSLRCGTIQRGDLVSTKFKDAEDAFRAMVRSRTKAEWTPTTLKSTSEASLPSSSMELSEVAAPEPRRLECAFFSYLMVGKLFVYSRAATDLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XKE4</accession>
    <name>A0A6G0XKE4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_003763</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000042">
        <property type="protein sequence ID" value="KAF0740873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XKE4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000240"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF109">
        <property type="entry name" value="RIBOSOMAL LYSINE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0740873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="337" mass="37247" checksum="40AD1C7E73D88ACD" modified="2020-08-12" version="1">MVKRTSLVYLSAVIFFTSPFVPKLSVSSLPLNMNILIVEADAWFEGHRRVRVPKGASMEQLYRAFYEQLNVQPQSSHLELTMFDPTTQSIVPLVHQGQIQSHARVFVQDHSAQQPILAIASRSFDYAFDKGEFKVLDKPLYIQEVGNTGKGTGLTIWDGSVVLAKYLESTSNPSHNVQGKRVLELGAGTGLVGLAAAFCGASEVTITDLAYTLENVDANIRANAEALSTSVVSTHELDWFAKDIPDSLRVQTVDILVGSDIVWVEDLIPPLVDSIAKLLYHSPAQRLMLLAHQTRSTKSDTLFFDLLIQHDLVADEIVAPEVVTDKIRLYQITTKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XKJ5</accession>
    <name>A0A6G0XKJ5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CAAX prenyl protease 2/Lysostaphin resistance protein A-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_003761</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000042">
        <property type="protein sequence ID" value="KAF0740871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XKJ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000242"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004175">
        <property type="term" value="F:endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080120">
        <property type="term" value="P:CAAX-box protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1/LyrA-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 2/Lysostaphin resistance protein A-like" evidence="2">
        <location>
            <begin position="221"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0740871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="395" mass="44454" checksum="0E07ECE2A8AF0618" modified="2020-08-12" version="1">MLPEAKDNIWEEHYPLLQPNGTNSTIPINHFFSPEVVNAYTYGVQAFAVTLVTLSVLSLTGLVLCQLFSLSSIFCAFFRLLWLVSPAAAALSLRHIAGTHLNFRYNVMAFPMWEIPPLADLFRCYPKSSIARVLSMSFFIPLLCQVAAYTLVAATRMVNPFNRVFVERAESVFSFDNQDAKDGGLVFYVFYLVIAGVLWDPVPPRRYDFGVAVDVKPIGCSWLLLCLFQEIGWSGALYPALDIIFGHSAFMASVVTGLVWAVWHWPFIIAEKYKIIPAGSGYSVVEAADFEVLSVLTIFTILLVGSRLIMCWIQGKSSYVIWSSTVYHASHCLFIVSVFGQLTGPLYEKAGDYPYFSGEGSICLVVTTWFSTCILSQLFRGNYLKLLSRWRKRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XKM4</accession>
    <name>A0A6G0XKM4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_003871</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. MFSD6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000045">
        <property type="protein sequence ID" value="KAF0740739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XKM4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019032"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024989">
        <property type="entry name" value="MFS_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051717">
        <property type="entry name" value="MFS_MFSD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172:SF41">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12832">
        <property type="entry name" value="MFS_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="207"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0740739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="405" mass="43877" checksum="4F768D1A19B4B989" modified="2020-08-12" version="1">MGEEHLWAAKAVCAINSFASSAQNVYLPVFFSAYFNKFQIGILATIPCVCTMVSPPIWGAVADLFRRQRLIHVFCLVTATLLWFAIQYTASSFTATCVLVFVATFQIGPTGALLDQAIMALIECVGSEYGKQRLLGAIGWGSSAFLTGLVVNAYGISWSFNIFLIALVPNLVALSYIPPPDAPTHTADGGSPSLSFAHGMRRVFKKTDVLLLLLVVLTGIMLGTATSYLTLNLYELSHSTTLIGVAIWLETLSELPAFFFADELLKRIGIVNTLFISILGYAARITCYALMTEAWMALPFELLHGVTYSLSLTAFAKYIYEAAPPGTQGTMMGLLNSMNGVGRGLGILVGGYLYEDFGGVRVLWWVADLGVPLALLGLFVFSKSLPSAESRLEVVRLISPKEIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XL74</accession>
    <name>A0A6G0XL74_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_003592</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000041">
        <property type="protein sequence ID" value="KAF0741020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XL74"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006570"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="306"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0741020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="351" mass="39869" checksum="4A940A88E3AF083A" modified="2020-08-12" version="1">MEEHSPEKPAEAPSLRASKKSVAASTLTRRSARLKGNLPEFGLYEKPARTRKSVSKLSPLEISEERDSIESNPSSTGSAASKREAEDDPDLSPQSLVPPKLPAVPSPSVVERKNPGEIPPGSRSPVLQEHQDWDESNQDAGFFPTPEPFVEYPGDHDTSEGNLQILARFSDQAREESLVLHRQGFENLLVEQRLAQAAAYQRYMGMVETERNELRLENQEIRVLVTRILDQSRENEKTWIKAFNDALGRLEETFSNQLEARVATIRESFERQWADREMEIRIRASNSFLDSAEFQIAVENAIMAERQTLQNRLLRSEVEKEEVAKELEQTRSNLALSVNRIRIMEDDGQNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XNY3</accession>
    <name>A0A6G0XNY3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">pyridoxal kinase</fullName>
            <ecNumber evidence="2">2.7.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_002838</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyridoxine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.35" evidence="2"/>
    <dbReference type="EMBL" id="VJMJ01000030">
        <property type="protein sequence ID" value="KAF0742170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XNY3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002160"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008478">
        <property type="term" value="F:pyridoxal kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009443">
        <property type="term" value="P:pyridoxal 5'-phosphate salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01173">
        <property type="entry name" value="pyridoxal_pyridoxamine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004625">
        <property type="entry name" value="PyrdxlKinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00687">
        <property type="entry name" value="pyridox_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534:SF2">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyridoxamine kinase/Phosphomethylpyrimidine kinase" evidence="7">
        <location>
            <begin position="86"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0742170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="411" mass="45339" checksum="E9BF04CFBBBADC90" modified="2020-08-12" version="1">MAKEGSEDSRVLSIQSHVVHGYVGNRSAVFPMQLLGLEVDVLNTVHFSNHTGYKKFRGERLNGDQLLDIIAGLEENDLINYTHLLTGYIGNPSLLRAITTSLEKLRQRNPSLIYVCDPVMGDDNRLYVPPELVDIYRDEVLPFADIITPNQFECELLSGQSLKGDADVIAACQKLHALGPRIVIISSFVPSSDSEFLWLYASEQVNGISNQYKMEIPRLKEYYSGTGDMFAALSLAWLSRYPTNLKLVLEKVIATIQAVMKRTSEAKSANRELRLIQSRHDIESPQVVIHAQLLHSPITHVVLDSRAFHQESVAAELHSAGVATILLTYSTQAETPSSAFTQVSEQSWKLDLAFAHAFSWSDVCASAGVLPVNALFLSQAASASSDNDIEYHVATDVASAVALISKRKQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XPJ9</accession>
    <name>A0A6G0XPJ9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_002525</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000027">
        <property type="protein sequence ID" value="KAF0742423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XPJ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002386"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46347">
        <property type="entry name" value="RING/FYVE/PHD ZINC FINGER SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46347:SF1">
        <property type="entry name" value="RING_FYVE_PHD ZINC FINGER SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="7">
        <location>
            <begin position="25"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="33"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0742423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="219" mass="24429" checksum="68C3A185D874418C" modified="2020-08-12" version="1">MHHRSDTFAFDMTADSFHDADDVIEVAEGTPYCYICLDSMNGPSGDAYELMAPCACQTYIHRSCLDGWRRMSKTEKPQTHCPTCKTAFQMEVSTLPLTRVERAIQTVSTYWFPFAWRYVTIVWVLLFVADFSHWCGADISSKLSLLCGYLSSSTLSILFPVLAVCLSVLVAIILYNVATGFLYSFGKTPSIVATTPLKIPDPPRVLNLRPLLTNTASMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XPU0</accession>
    <name>A0A6G0XPU0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tyrosine-protein phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_002547</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000027">
        <property type="protein sequence ID" value="KAF0742447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XPU0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009354"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF527">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="70"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="2">
        <location>
            <begin position="248"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0742447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="355" mass="40714" checksum="599D444F2BC05027" modified="2020-08-12" version="1">MAMWKKVLGGLSAAETRNTPRYATLEDELDGEMKFWWQPLQEAIAGGKIHEYAPVQEFLRKSALMNEEAFAEEYREIRNSVEGAPWFQAALTPQTAATKEKNRYRDVLPFEKTRVRLRPQTNDPAGDYINANFIFEDQYIACCAPTPNAIVDFWSMVWYENVHVILMLTNFVERQMLKADMYWDTKGQIVDVGEITIQLKQVEVSSRGYTIRTIELTHRSLSTKRTLYHVQLTTWPDHGVLQDFGVIQPMLRLVKGLNQRNRCESDPQLPRPIVVHCSAGIGRSGTFIAIDTILKQLREAATSLSNPDTAERLANALNIRSIVHRLRCQRPGMVQTTEQYQMIYEYIRAVLAGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XPU3</accession>
    <name>A0A6G0XPU3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Vesicle transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_002607</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the SFT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000027">
        <property type="protein sequence ID" value="KAF0742514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XPU3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012314"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011691">
        <property type="entry name" value="Vesicle_transpt_SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137:SF6">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0742514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="193" mass="20223" checksum="BCB2821555F961D3" modified="2020-08-12" version="1">MDRVRILFGGTSSSSAPASSAVEATVAAISIKMPKLTMSAAAAPPKEDTLSDSSFGCTSLTKTQRLYGFIICFCLGYFINLLATVALLGGSRNGAKFGIIYSVGSVVSLCGSGFLAGPMEQIKSMAKPVRRVASAIFLVSIILVLVVAITVQSAIGSAGPLFSLSPVLRRCLVQCQLHSVWPQDDQNDGKQML</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XQ64</accession>
    <name>A0A6G0XQ64_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase C51 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_002493</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000026">
        <property type="protein sequence ID" value="KAF0742593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XQ64"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014232"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.10">
        <property type="entry name" value="endopeptidase domain like (from Nostoc punctiforme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007921">
        <property type="entry name" value="CHAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051705">
        <property type="entry name" value="Gsp_Synthetase/Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30094">
        <property type="entry name" value="BIFUNCTIONAL GLUTATHIONYLSPERMIDINE SYNTHETASE/AMIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30094:SF0">
        <property type="entry name" value="BIFUNCTIONAL GLUTATHIONYLSPERMIDINE SYNTHETASE_AMIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05257">
        <property type="entry name" value="CHAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50911">
        <property type="entry name" value="CHAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C51" evidence="2">
        <location>
            <begin position="45"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0742593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="369" mass="41172" checksum="38771849BA668AC6" modified="2020-08-12" version="1">MTTHQRRWPGDNPNGEKTEPVGLPHGTVLGSFHGVEGYNNNYKNNPHATDENYDGSNFLDGVCTGMKWQCVEYARRYWIVNKGVVLPSLSWAAHIWDRITHVSRRHDFAIVPLLKFPNGSTEKPLVGDLLVYQSTPNQWVGHVAVVADIVEKEDGQKALYVAEQNVHNNRLWIGGHYADKLPLHIGTSDDGKLTYTITHPDPDLVLDGWVRADLDNAVFRAPWTRPAPRLPVSGIYDQESAIALQKFVGSFPDGSHGGMTNTDIRNVLRQYGEPNEAPKSPNVHELLSSLRLFLKRHSALSSPTNDNAVPDLNECPGNTRCVCRVIMREEIGEEPAPTPCNTTKALQTFLNNVHHPHDLRSAVQLVQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XR51</accession>
    <name>A0A6G0XR51_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_002301</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000023">
        <property type="protein sequence ID" value="KAF0742907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013303"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050991">
        <property type="entry name" value="ECM_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708:SF2">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708">
        <property type="entry name" value="TENASCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="690"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="841"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="981"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="1233"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="1259"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="1260"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="1358"/>
            <end position="1458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="506"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1442"/>
            <end position="1465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1442"/>
            <end position="1454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0742907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1629" mass="182564" checksum="B539B60B4527AED8" modified="2020-08-12" version="1">MSSDDDLDQYETNPFDDAFAPQGEKSNNDEESKTSGSKNKGGTKGTFDFHQWVARKDKYERVLQALHALSTDRAANQDNWFECAVALAATDCLLKVGRTDKCDCEGVCRDPAHAVSKQRTRCQCPAPKCSICNRCIGTTVGVITDKMKEVMDLYRGKTRDSDLEIALQLSEMAEGKQLNGVKITGLAMRMSKSVLSQCSVLVGPDETKLQRPCSCPLRSLGDHWIRWTKANHSFDKVRLSEAQAKKFGGATRQLMEFIEEDNVYLLTIKWRVAAKPQKGDTAKIAARRCLSADEKKLNTVFKALCKKYWMQAQHRVVQVLREKMEARGKQSNDRDDGAAKTPAEMEIAILNNLGVKRMLQWVEQDKEAIQAKEEETQREKQEEGTLAHHAWVKKKDRLRVRVPTSSGRHDGGGGIKPMWKPPRFDFSTNGVVRPKKMDIPSCAVDLMRHSGLKYVHAMSEGFQGRGGDLDKCREVLLKKGHVFKSNFNLNDPDSAFSEDRYHFEKQAKKSKAGTTGSGGGVVPSREDGSKEAYAQWMAAKGRRDKALGFLHHMTKPKDMEPEAAPAKRWEEVGHALKGVDRTLLAAWMEWSDGFMTQGRCRILWESFPPIACDVHSTSSAIRDIFLKLLHRKEVNYKEAFLKHATKKHLKAVKEGLADDEEMKDDDKLQTYAQMTTKEFAKFLAVVGILLQPEECERVVEYFDSNGDGTVTMQEFLAVTGEERPTQCHGDTEIALKDVCMWETVCHECGMVNAFQLVVGLKKDKQRMRAELPAHAKRRQLSRFQCHPILVMRDVKEQAPYACDYSGWTPENAQESLAKLDLWSVENRERKALQKLVTQGSPPEAPTLFKDDDASLDPTTMLLLRWHPPPVHGNNGAAFYVLETSGAEGSTTFKQNIFREVVRDPQDFHDNQGEPRYHFVMTNLAPNTKYALRLRALNAFGAGPYTFGYFTTAPTAPPAPMATKVTANSIHLSWNSSIWYDTQLKELRAVFDEADVDRSGEISRDEFVEEISKRKPRILDFLQKTTLTTADTTGLPLSIFDAIETNDSETISWDEFVRMFQASIDWDAVAPPSGEKPAASATSSKRASALTVRSRTRYVLKQCVDEMAGTYTEIYHGSKPFFVVHGLVAGTAYQYRVQALNEDDFASLHSAPTIVHTALTTPSAPVVLAVTDGSVTLQWNEGSAAPGGDQLTLAQKAKKLKKGAVLDDSIHRMLKEWAKETMVDTPSIDFVGKFKRYDVDGSGFIELPEFKTLLTELGVAPTAERIQAYMTEFDTNNDGKISFDEFKTWWNKEDVAYVLKRSNHGQNDMANVCYRGDGTKTTVAGLEPNSLYHFRLRYVSSHATSGLSSACSIMTLPCSPSPVGVIEALATKLRLKWHPGHHGADRYMVETKLVECLDDKKSVKAKDEWTLGYEGTETTATIPGLLPQGRYELRLRAANGQRGWSSYSQPTQVETTAKDPPMKPGSAADRFKIEVSGPGRMAIGDTILFSERLYFGDKNKLMDEEERRGKSKSSKQGLESVGERTIAARVSNIVEESFPRRTTIVMLDVAWSTVLLYDSNQQKTLAPNAVLTAETKIARSEAAILKYETFRLPWQDEVARDPLAKNRDIDHLDDANTQAWATWIKAQRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XS39</accession>
    <name>A0A6G0XS39_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_001994</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000020">
        <property type="protein sequence ID" value="KAF0743202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XS39"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011763"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0743202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="172" mass="19510" checksum="193E99EABE0A7F48" modified="2020-08-12" version="1">MPLRYFDSVDALYRWGLTFDDSNKLHRCRIALRLAALKIPEGATYGLALLVDAANTMELVELTDYAVQAYHADDATKVVAAFITDYPQLVDPALNIVHRQHVGELLVSEKAAWGRHLHMGQLNMPKLLISGRFETPKLLYSTMAELMHHMHGGSETVDEWFLKEFTPSGDWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XSR4</accession>
    <name>A0A6G0XSR4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">THH1/TOM1/TOM3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_001920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000017">
        <property type="protein sequence ID" value="KAF0743449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XSR4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021176"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026226294" description="THH1/TOM1/TOM3 domain-containing protein" evidence="2">
        <location>
            <begin position="16"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0743449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="121" mass="13166" checksum="4BF1DA4AAE207453" modified="2020-08-12" version="1">MVVYLVFVFSSMCLAQSADLAAVNLLAPKLTIPLHLVIAFVYTVAFASAVLAYKRQFSTTSSPATSPTTAHAPESRWNDALIAFMNFLQIASQSYQAFVIFNDLTRLGAILSYALLVLLCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XUM8</accession>
    <name>A0A6G0XUM8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WRKY19-like zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_000773</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XUM8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007820"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056866">
        <property type="entry name" value="Znf_WRKY19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827:SF1">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24906">
        <property type="entry name" value="Zf_WRKY19"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026185869" description="WRKY19-like zinc finger domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="WRKY19-like zinc finger" evidence="3">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="WRKY19-like zinc finger" evidence="3">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0744284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="194" mass="20385" checksum="BD9628EE09D35DBE" modified="2020-08-12" version="1">MSVLMMPTLLPPSAAAHALCNVQGCYRFAKCQGSCLIHATALSLYGGPNSPAHSASSSPRSTTSSSNSSSKNRRCFIEHCVKFARIGGLCTQHNMQLSNQRRKCSVEECSSYARTAGLCIRHGGGKLCSVEGCTTVQQSGGLCRAHGGGSKCKPCKVAGCTHFARVGGLCGQHKKQKTLHEESAAVLISVLRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XUY3</accession>
    <name>A0A6G0XUY3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_000947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XUY3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010419"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0744470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="36147" checksum="330175246E869E38" modified="2020-08-12" version="1">MSEPSSSQVHEAPPQAPAHEGSLPRQPLEFRDSEDSLDIDSERSFDVDGEGYASACEEHEDESADVAASPVTSPRGIPTALPPLSNVHISSSDTVPPARPMFRDVDNRVSTVATNVPRQASCSTFFLGEESQTWIEVNWMGEPLGLELQRFKARDASTVDIVWREGSVGLTFGIEQATRQVVVKRSSRNERDVYPGYILFAANGQPVMESNFDATMQVLKAGHDAGRSQLLQFKPPPASPLVKAVDPRSVLGHAGVDHSYELKTINGIQTRYLSLEQISITMRNAVKPCVLHFALSDDAEELQRLQNAAITSNRYANATTLAATAVFAAVCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XVP9</accession>
    <name>A0A6G0XVP9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tubulin--tyrosine ligase-like protein 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_001216</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XVP9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021775"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070736">
        <property type="term" value="F:protein-glycine ligase activity, initiating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051437">
        <property type="entry name" value="TTLL_monoglycylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45870">
        <property type="entry name" value="TUBULIN MONOGLYCYLASE TTLL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45870:SF2">
        <property type="entry name" value="TUBULIN MONOGLYCYLASE TTLL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0744761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="38832" checksum="1DCD97BC05AF04F3" modified="2020-08-12" version="1">MPNGFVVDEKFPDVIEYLVNEDWVACPHHTYPNCLLRYTNYVKIQWQYVKPHQTINHLQHSILLSRKHELLHHLETRPSIHSFLPRSTTDIDFWFKMFVYTQALLVLKNREIHAQRLPIARLIGDEMRRLNDPTNAKLHGLQFMNQDFLGRHSQAINDLLNPDHSQEKIENSDPHVDDELLLYLEACDPQFHFNSTRNLWIAKPSGLSQGRGIELISSQAQFDAFRKAHDKAIVVQQYIERPFLIFDRKFDIRQWVLITDTEPLTIYWYDKCYLRFASKPYSLAHDDSLDDKFMHLCNNSIQKASDIPNHPEIPGHMWNLERFQLHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XXL1</accession>
    <name>A0A6G0XXL1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_000317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XXL1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013249"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0745287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="89" mass="8259" checksum="234840B376ED0D73" modified="2020-08-12" version="1">MTTPIRFVAISAGVGSAGVALAGVGAGALVPTAMSYFGAVVPGVGTLHAAGGVAATLQWTAATLGSASTVAWGGAIGGAVGSVVGAFWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W490</accession>
    <name>A0A6G0W490_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_018858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000361">
        <property type="protein sequence ID" value="KAF0721871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W490"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015423"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34415">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34415:SF1">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0721871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="294" mass="33612" checksum="F7DA642AB6D7BA6C" modified="2020-08-12" version="1">MQKQPLLPVVSIVAAREGAPRDDESSSDSDYAEDDHGPDESSEGDEAHAEHENDTANDDDDEEYVTENTKVIQLVNYTCCAKRCIFGRTREMDLFVQSLDEMSKEMQHTCILTSLSISIAMMNKRKSRGKGLRVRYTYVMPYLGYVCKQAFEACFDISGGSLSRLRKQVSRSIVPKKHGNISNQNAKSVDYDTLKAWFQPYAAAVGHTIQARRKTRVKTEDGQTQIKYRTDNVIVLPAYITYEKLHHDYLAHLHNRGIEARRLPSEKTFRAYIKNSFPDIRLESKNHKVRKNPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W4B7</accession>
    <name>A0A6G0W4B7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_018911</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000364">
        <property type="protein sequence ID" value="KAF0721805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W4B7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005827"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0721805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="141" mass="16004" checksum="ED6D549403CBA30D" modified="2020-08-12" version="1">MTKFIKGEKLSQRQSKTTEEYDERDVLLTDIRARIDDYEQVGAEKRQAAKRKTEGIQNSGLVMRQLAMDELASSSSDLPNKKKSKRPAPTVNINALVETIQTAIDEKKQREKRVETLQSSAWNSIVNKPLVKLRSSKRTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W4X0</accession>
    <name>A0A6G0W4X0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_018724</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000349">
        <property type="protein sequence ID" value="KAF0722088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W4X0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019719"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0722088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="117" mass="13158" checksum="7180AC0557DC7B70" modified="2020-08-12" version="1">MSISSIESFYDNQDQDDEFDPLFEQLKASLHGQSCGHCGKIGAAIPCHGNCGHSFYCSHDCLVFSSSTHRHACLSIRESQTSDTNLWWEDDEDDDDLPLELNLAIDAIVGQLTHKWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W5D9</accession>
    <name>A0A6G0W5D9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_019000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000372">
        <property type="protein sequence ID" value="KAF0721667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W5D9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009908"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052050">
        <property type="entry name" value="SecEffector_AnkRepeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586:SF3">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140860">
        <property type="entry name" value="Pseudo ankyrin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0721667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="701" mass="79951" checksum="9453844873E3F843" modified="2020-08-12" version="1">MRSSYAQIRKKRLRSFSAAPKTSMAVLFDADLMHLITDFQTGIFRCLVPFFERDKNIDSFRGDELMFLLYISNQKARIWVNVLREGKLALVQKLLRCTSKTNRALQLHDSRYTTAANSRDILDLAAETATLEIVQFLHEHDVSCSKAAMDRAAARGHLDIVKFLHQNRTEGCSKDILIGILRAPSTSDLSNRVACIKYLVEHELLHPNVSHPYECMQVIIQRNLLDIIHLFHTQGMDRFFHITTMDYAAKCGRLDIVRYLHEHRTEGCTSHAMDQAAEHGYLDVVSFLHNNRTEGCTERALTAASLGNHLNVVEFLSSSRTEGWSHPETIDRLAAQGNTSMIEYVYKKDRASAWCSKEAMSAATAYGHLDTLKYLHDKENDASCHRMAIVDAVEANHVETVEFVLRNREEGLTRRLLSALIRRGKMALIQLVASRRPQLLTTQALVLAVESNELAIVSWMIKEYPHLSSPLVVNLLVKKNKRQLVELHHMLGLNDCFTPAAMDIAARHGLSRLVVFLHTHRSEGCTVRAMDGAAENGHLKVVNYLHTHRTEGCTAYALDKAAERGHLRVVQFLLLQNKPWTSHALNWAVQNHHTAVVKALLANKSPQACMLHAMQHACHPRRIALANLLRRFPIRGCVCEPNEYRIIQQREDNSWFYHNNRIDDEHFSSDEDSDEETEDDEGDMDFVIPMWIHHVENHLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W680</accession>
    <name>A0A6G0W680_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cilia- and flagella-associated protein 157</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_018323</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CFAP157 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000330">
        <property type="protein sequence ID" value="KAF0722590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W680"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002176"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038844">
        <property type="entry name" value="CFAP157"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31954">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31954:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="4 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="524"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="50"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="149"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="317"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0722590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="579" mass="66332" checksum="FAE638D87134DF87" modified="2020-08-12" version="1">METKTPPPQVDGAPSAFVPKVRDIGTIALEAIGKIDTVLAFELTVMNDHMKTVEKENVILKAENDALKAKILQQREDEADIYYYLHKKLDANYQVIAQLEGDIEAVKQERDAMDKMFHQQQEETQSAFAKEKKDLTERIESAQDTLHALEVFRERKVELEDTIAAMEATLAMEKENHKKQVLEMERRNVQEKERIKKDMLMKIKENKQNLLARTEDQLDSTTKRTMMENDQMISELQYQSKETEKLLAKYKALETEVVQLRLQLKLNKETEMEMAKRTHFYQKLIKKLNDRARSDAAREADDGRSKDQLNKANGEMLEVLESKSQSLQAQLRTLSEELHDTRTQLEAARTEKHNMLAQQDDTLRFLLTAITDITHQLALHDRHRPVTLKEWQAGDIIPAKLDDLPPSDVRKVLQMLFGKLHAYQSQIVETTRALPQKQHGTELPPIKPSQQQYQTQQHQSRADQIEILKALANYGPSTVPERPSRNPSTEQLHQRSVACQTLSNWSETKSNARKNVSNVVVHPQQARTLPQESPPKAPMTAEGRVEAAPSLISTRRPVVKKRIVLPEAHRLPPPGGKNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W6A4</accession>
    <name>A0A6G0W6A4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small nuclear ribonucleoprotein Sm D1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">snRNP core protein D1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_018222</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Essential for pre-mRNA splicing. Implicated in the formation of stable, biologically active snRNP structures.</text>
    </comment>
    <comment type="function">
        <text evidence="6">Involved in splicing regulation. Facilitates post-transcriptional gene silencing (PTGS) by limiting the degradation of transgene aberrant RNAs by the RNA quality control (RQC) machinery, thus favoring their entry into cytoplasmic siRNA bodies where they can trigger PTGS. Does not participate in the production of small RNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the snRNP core protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000326">
        <property type="protein sequence ID" value="KAF0722745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W6A4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000653"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01724">
        <property type="entry name" value="Sm_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000008">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034102">
        <property type="entry name" value="Sm_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="9">
        <location>
            <begin position="4"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="89"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="105"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00054531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0722745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="120" mass="12811" checksum="FD9D0D53CA18D059" modified="2020-08-12" version="1">MTESMCRFLMKLTNETVTIELKNGTVVHGTISGVDISMNTHLKVVKMTVKGKNPTSLDSLSIRGNNIRYYILPDSLNLDTLLIDDTPKQKVKAGAAASGPGAAKGRGRGGRGRGRGRGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W6V8</accession>
    <name>A0A6G0W6V8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_018879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000363">
        <property type="protein sequence ID" value="KAF0721813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W6V8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004188"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021360"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0721813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="531" mass="61301" checksum="E4ED355826740415" modified="2020-08-12" version="1">MMNDMVEEIRRPTTTASFTRWSFGYNIIFILNLVTTPFTAYLTEPRPGEVNLNKLPTWNSFDEYVVVMTGYLSGLYNNKTMDASVVSRRDPGTNTFAFRHDMTIPFQVDDNDAFSTLLKIAICTILWTRHSILCVEFYESQRNNSKSNATVANVPARTSFGDDMDRNVHLDGRNRPESLYSCAYRCVLSSYVLWMLWKRYYRHYAVLLSNLRLYGIESKYIRYEIVVGDPVYAILSDPVIAFGLILDFWWNLDYVSLGLMRVTQFQDFWMYVTGCIYLSRYVWYSYFGVQIMSYVVKRRRWELKFTPLDPALLAIGAYVYCGPVVSILATTKLVWIFYLAWGFFLPSSMRLQATESITGATIMSGIMTTLPLVFSRLSVVWKDRKKDRVIAVGIKQTDSFFSDYDYNDLKALILLTLTMRKQSKRMRGGILHKLYQENPRYRQIALSTHRAADCFVLCYNADGAIEDRIRLSLLSYLNPQLNDPKFAIPTCTSSHSSSVCVINNESCPTFQPQSTSSRCIHRAESGCLWVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W775</accession>
    <name>A0A6G0W775_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_018054</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000319">
        <property type="protein sequence ID" value="KAF0722979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W775"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010221"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026039000" evidence="3">
        <location>
            <begin position="27"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0722979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="164" mass="17283" checksum="ED0CB32D0B562E63" modified="2020-08-12" version="1">MPPRAFLARISSSLLLVSCLLAAVQATPSTDATSPPPVVVVNSALTTSSSVSSSSDSDTSSTTTVVAISIAGVVAIAAVLAVIYVRRRRNQATATTPEAPQTREFSRESEFHTPAKQGRRMSVELQIIAEPSPPGITQSSIDLWDDLENLHTKSLHHSGSSSPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W8Z4</accession>
    <name>A0A6G0W8Z4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_017544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000301">
        <property type="protein sequence ID" value="KAF0723577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W8Z4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019874"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0723577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="137" mass="14916" checksum="3E790190F9742AE6" modified="2020-08-12" version="1">MCIKCSPLWDVRRAAALMSTASIRVCRSCSAANPSNQSPTNSQSSMASYATGGSGGTSTHRKSSPLVKVLDTFPKLDVSISARYEKEFRPAADAALWQDLEQADSSADMLGLLRQLQELKHTDDKLPSKEKRILLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WA35</accession>
    <name>A0A6G0WA35_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_017929</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000317">
        <property type="protein sequence ID" value="KAF0723058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WA35"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018638"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0723058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="103" mass="11381" checksum="6E20BBA3E492C9BB" modified="2020-08-12" version="1">MPLFPLPPNFFQCSVPLTAQERRQYLSEAREITSDVIRKSNSAYAPMQWTLTDSSDDVQIYHGLDATAPLHVVSCLGVTTVHATLEEAASHGQIKSTRRCGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WB46</accession>
    <name>A0A6G0WB46_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_016878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000270">
        <property type="protein sequence ID" value="KAF0724471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WB46"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026038694" description="Secreted protein" evidence="1">
        <location>
            <begin position="28"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0724471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="104" mass="11617" checksum="710B59EDDAAFAF9D" modified="2020-08-12" version="1">MHANTLGCLVWPQRLLLLSLLLQLGFPECSVFQSFVARIEQSVPVIAQDQLLLVSTGIPTFNHTKHASCHGESAGDDRKTRDNLVRHLETTNMQSAHRTKKLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WBC0</accession>
    <name>A0A6G0WBC0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_017576</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000303">
        <property type="protein sequence ID" value="KAF0723543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WBC0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002918"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13999">
        <property type="entry name" value="STKc_MAP3K-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF214">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="234"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0723543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="503" mass="54636" checksum="7A2FED4B50D4CA26" modified="2020-08-12" version="1">MNSVGPEYYCGTLFNGLGSGYNSTSYFDQCSFPKAIAASKVDVALIKQIDCTNRMCRAVFQSLEQTSRMEYYTNCTLTDTSTSKKISFQEVVNLCVNITTVAPSTAPTPGGAAAPIAANPASPSSSPSSSTNTSSGNNTGTVAVIAVAIVVVVGIVVGAFVYLRARRKQQPPQPQTGDTYLNMNAMEQPPPTIATKGTASTIQSSIGSANQQFSLAPGHVLRDLELYRIRAADVHPIKALSKGAFGEVWLGELFGEQIAIKKLISSKNTEADQQKFTSEILLLSKIECAYVVKFIGVAWTSPFDIMLLTEFMGGGDLRQVLETNKKTKKLTWTHKFKIALNIAEGLVFLHSMDPSIIHRDLKSRNVLLDSSFNAKITDFGIAREIDDSTLTAGVGTYRWIAPEVLQDGHYSESADMFSLGVILSELDTEVIPYSDLRNAAGKPLMDTAIMARVMSGELKPSFSPECPRWFVELAQGCLELDPSERPTAMKVAFNIRSRIQGFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WBE6</accession>
    <name>A0A6G0WBE6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_017294</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000292">
        <property type="protein sequence ID" value="KAF0723914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WBE6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016076"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="34"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="331"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0723914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="365" mass="41335" checksum="830BBAE944EE5CFE" modified="2020-08-12" version="1">MAMPSPRPTSKQCYPQHSKAPVCNVGDKIIAANQMNGSATALPPPSNSPSKPTTPPTFSTYSSIRPTTSMASPLSKRKNKWQKRRPMTVSSTFRPISIVELPGPECNPSFGLLQLDEWLATYEHDILQYDSLAAFAHVKLDEARRLSSKCPHPMNRFRVAVMCNLFERAACALATSESFKRYSSCILALRDEILDMVLVDVQDDDAVATIARNVPRTLSFFLQKMPHVIALRLEQEKKAMDFHKHQAVLQKLIQTMFKNVGSVFQAWKLFAKAQREERLSKKAAKITRTILATRNQTRLVFVSWARHCLVAKLEAQRLRGIQLEREHTLRVAELKKSMAQSTDTIDRLQAELNMLRVRHGDEPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WBM1</accession>
    <name>A0A6G0WBM1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_016738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000266">
        <property type="protein sequence ID" value="KAF0724675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WBM1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001944"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022127">
        <property type="entry name" value="STIMATE/YPL162C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31735">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YPL162C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31735:SF1">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YPL162C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12400">
        <property type="entry name" value="STIMATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0724675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="238" mass="26480" checksum="2B1ED7D60F8311C7" modified="2020-08-12" version="1">MAANATTPVAIHAANNCTLLSGTFETLVQIGLGIVALSVLFVKRTLEKPQRPFQVWAYDASKQAIGAGVAHAANLFIAIMLVKMAKSENATDECAFYFINFTLDTSLGVVVNWLLLRLSMAAAIHFNWTWLQVPGYYGNPIRASVWLAQLAMWIVIVLTAKMIIARFIYALETPLNNFGNWLFDPLSDYPKVELLFVMVACPCLMNMLQFWITDNFLKKPAAKSDDDKSVVNEKTPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WBU1</accession>
    <name>A0A6G0WBU1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase M14 carboxypeptidase A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_016648</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000265">
        <property type="protein sequence ID" value="KAF0724717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WBU1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006121"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0724717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="98" mass="10818" checksum="6E44AD1721B822CE" modified="2020-08-12" version="1">MGSNYKAETGATLYPAYGAFDDYHYRTYRKPVLTLEIAGTDFVAPASTIRTRGAEIYKGFSQFAKETITFGSTKSAFLEDATVDSVNVTTDFDHPILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WC04</accession>
    <name>A0A6G0WC04_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_016568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000261">
        <property type="protein sequence ID" value="KAF0724819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WC04"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001834"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013445"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="578"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="623"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="671"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="699"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="755"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="886"/>
            <end position="906"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0724819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1141" mass="127933" checksum="439BF09F330BC31C" modified="2020-08-12" version="1">MMSRVVPYQFGPYLPIHGRKSIIASIAAAYVVASIASGLYFLDSVNTSFSNDIWWPHYNLSAYQAFIIDAANDILATRSTGQWDILSSSISKDYSSPTSSTDVNPSYVRQLLFHELTTIEYAVANLRSLSADQSLGVFTQYCWVDFNQRFEMAHTTLRQARCRQRYMANAATYMESVLRNQNWNEFTLAYGGDGGLFTVTIQDAIQATEEGRLWLARTSTAATTLTETEEVAFWKTANLTKFQLPWHNAFLTGIAESIAIENAWGMTQQIYIKQFSRKKASWTSIILFWSLINDLTSLQALNRSAVRMASNSFVQSPAIDLERLASRMEVDGTYVNQRKLFRSVLGPFNSVDAWFVVSPTELNTLVQNITLPRLTEKLLTFYPIPPSWNFSNATYYGGSPLCVASDGRSYVQQTFDLSDNCASPQPLSMEVSLSTATMALIIMNATKNSSWLIPSICASQTTNLCESFLKASLVIAGNMTVNASLVSAARKAVQNLNVSLMQFAVLPNNSWTLLQQPLIARDTVWRFYGWYYLADWAQSRRSVVLFEGDFASLALMSTRSTLQSFLTSTGYLSSATRIVSLVALYTSSVLTFFALLCGIHLVRLKLHDVCEDNILYFNRVVSFVWVGRPLLLVRGIAALIMLSTSQIELVYVVDQGRSRLEFSPRLWPKTVIVAGESLWVAYVVIDFLQLIWSQRLSKYFVTLGSIFAWAVVVAIELLAPVYPVATLNRQCEAIDMDSSIECSSGLVQIGSFGRVITFIAVQVGCLIFAAAVTVIFQKSPQGMAYRSYQHHILGSAEPYFIVHDSDETKSWSLDPVSCVMAGLIPFTFFNRRHFVFDLKLWVIVKNTSVMPTNSICFTKSEPTLPRDTMVTAKRLRKKYMIWLDKLLLLGGTSYMIAAIIGSILYIQVARVNFANDLSWANFNLTVTHVFLGSWLNEQLALGTDKIVFNLDASDLSYLGEIDPNSPSISMPSTFGSHVQHSEFSSLQAAISSLRTTQACSVPWIFTQYCYLDFSKRWELANSALRQKRCIDMASNGALYLEALLRNVVFAEFLACWGDAFNISIANELAQSKEGREWLTQSAFSSRLSITDEIQIWQSYNLSTFDTQWQNFKSIGIQSTYSIVNAYGPHTLAQSMRNSQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WC54</accession>
    <name>A0A6G0WC54_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_017055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000277">
        <property type="protein sequence ID" value="KAF0724206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WC54"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0724206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="157" mass="17745" checksum="DD99A5548507D1A6" modified="2020-08-12" version="1">MCPREDQVKSPSGSKSHQVVKMAKSSTKEDYLAFLDPIFVQARVENLHYIFPLSKEKGIFLAPNYQATKAATLLPNQHWGNQTQLELGTTAGSLELEASLREEAKGKIACREDRIVVSSISCVFGYIASRHPFFLQNILYSVKNNGRQRQNRREIAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WCW6</accession>
    <name>A0A6G0WCW6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_016205</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000244">
        <property type="protein sequence ID" value="KAF0725308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WCW6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015065"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000027">
        <property type="entry name" value="Heat shock transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF206">
        <property type="entry name" value="HSF-TYPE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="8">
        <location>
            <begin position="10"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="112"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0725308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="175" mass="19932" checksum="3A08E3123EB70301" modified="2020-08-12" version="1">MLPRSISCMFLKKLFDMIETLPSELGGWCDHGTAFEIKDPREFERVVLPKYFKQCKFTSFVRQLNFYGFQKRKKETLLVAHEATESVVFFHPHFQQHAPHHMAKIKRKTNHSDTTSGGYDTPSASSTNDEVEELRADVTDIKNTLASLSAQLNQLTTIVTVVMHAAPKPASTQKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WCY5</accession>
    <name>A0A6G0WCY5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RxLR effector protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_017068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000278">
        <property type="protein sequence ID" value="KAF0724169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WCY5"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026339442" description="RxLR effector protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0724169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="154" mass="15976" checksum="0678C4FC7595A321" modified="2020-08-12" version="1">MRVSISVALAASAVVVFSQGVQDSPFKLTHQQVPTHYAGSSLRMLQGKGSGAGYTSRIRAAASSAASSAANTVKSASRTAANSVKSASMTAAHSVKVAASKTANAAKGMTGCVKSACSRVSSHLKPAPVYKVTPSMNDRLVRARERRQERLGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WD81</accession>
    <name>A0A6G0WD81_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_016324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000249">
        <property type="protein sequence ID" value="KAF0725172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WD81"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020452"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0725172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="398" mass="46087" checksum="08381E2B443DAA49" modified="2020-08-12" version="1">MLLWEMCQHTRFIGATTSEMCLWIEPLGLSRYAFWASNLTYESIESICIKFAFRCWICIYICYLLWAHYYHHYVVLLYNLRHLGLSNEYKYYKIVLGDPAYVILSDPLVALAMAADNWYSANYVAMAVAQVSQLQDAWLYIRGCLYLSRFVWFAYLGMQAGSFMIKRRQREDSFAPVDPALLAVSTYIYCGLIMSLICNTPMVWLMYGSWYVFLPPLMYQEAIETISLVIFVTLLMAILPLGFSRILVLWQHRQANRVRPTSSRMLKQSTSDYTYNDLKALILLSLSMRKHNVRMLDNPQYRKLPLSSHRAADCFVLCYRRDGSLGQTVRLSLLSCLDPQLTKRDLALPMCTSLHSSCVCYIGSDSCETFKPLIKGDRCIHLGASKQTVKHHNPRRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WDP4</accession>
    <name>A0A6G0WDP4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_015944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000237">
        <property type="protein sequence ID" value="KAF0725611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WDP4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017475"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0725611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="114" mass="13146" checksum="104433BE46EF649E" modified="2020-08-12" version="1">MKQRRKRCLTLEIAQDNDENCLGTKTQDDNAWWKSEYTLPPSGHLGAHNTIQPKNKHDDRLPLFPDTKIQIDPEIEIQVTTATSTTPQSSANKRRRMSKDRDLAIVLRRLDHAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WES6</accession>
    <name>A0A6G0WES6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_016553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000260">
        <property type="protein sequence ID" value="KAF0724860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WES6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015389"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0724860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="30084" checksum="81A6857D6F81D318" modified="2020-08-12" version="1">MHGWDPFTTITASLPATKSGDHEANRWRSQLHQQHVFCKAMAHDLLCQAVKRRAEAHNAQLPPAVDERIKVGDLVWVYIDQVKSGVKKKLAHLWHGPFCVLDKKHDYASVLEIQGRLALRNHRFHAEVHDSRLKPQRVFQLRPTERMDSQPPVDFDKGLYLPPDSFEPDPDEPQVFGIRAVRYTDHIKEYEVQLEPDGAWTWVAAISLPASTLVYEFERDLLHLDRLNMMVQTDFVPPNNDEDEDETKSEAGGGEEDDLPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WF45</accession>
    <name>A0A6G0WF45_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_015669</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000229">
        <property type="protein sequence ID" value="KAF0726004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WF45"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009522"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000009">
        <property type="entry name" value="Probable E3 ubiquitin-protein ligase HECTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF440">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NEDD-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="11">
        <location>
            <begin position="313"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="9">
        <location>
            <position position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0726004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="665" mass="74899" checksum="82DA85391988CEC9" modified="2020-08-12" version="1">MADVNSSSGMSTSPLMIVLVVVGFFVFAIIVVYCNRRSSSESSNEALLAEGMREFMPGLKREDVEELLQDAERWKCTVCAFLNVIDKPICSLCHSMKDVRFVEPTERDVISSKYIDSSQTSMSGQIVSGLRRTKSIGATLVRQASKNRLRRMTSFFQHVLLPEDLNAKQRSARMRKQWTREMQGDQIVWVQHFLDSEDFPAAYTIRLNPGVRSGTILEIVVADKVTQIPTSESLNGRSIAWMPVEHVDGSLSVLNSSIMPSVWQSLIALSKIAFSFKYAWFLHQASSLVTPFEELHVKTRCTRETVYEEAMENLLGLKDRALCSIIRFEFIGEVGLDAGAVQREWYMVVAQALLSESSGLFVVSNRDDNSYFINPNSEHDVQETTLHKQFKLSHLDAFRAVGRFMGRALLDGQVLPLHLNPVLFKAILGVPMTLDDVECLDRSVYKSLRYVVENSGVDSLALTFSETEQRGHFVTEINLIENGQEIEVTDANKYEYVDLKVRYLLFTRIQDQLNALVQGIYDIVPPELLIPFDHKELELVLCGLPEIDVADWEANSVASSNLKDSAVLVWFWEVVGSFTPEEQAKLLQFSTGSSRVPVQGFKGLTSYDGRICYFTLKGLPYVPGTFPTAHACFNRIDLPLYPTRDLLELALRALLLSEATGFNIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WFS5</accession>
    <name>A0A6G0WFS5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_015962</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000237">
        <property type="protein sequence ID" value="KAF0725629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WFS5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009062"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009725">
        <property type="entry name" value="PRK13252.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="23"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0725629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="484" mass="52091" checksum="F4C2166857A4CF50" modified="2020-08-12" version="1">MLRTVKAFIHGRHVTGRGVARTLLDPHNRTPITQFNDVDAQQVAEAVKSAKEAQPLWAKMTPASRGAILRRAAAILTQETEKVQMLECIDTGRVLAEMEADILSATDCLEHFAGIAPTLGGQMLDIHSPNWAYTRREPIGITAGIGAWNYPLQSAAWKSAPALAFGNAMIFKPSEETPLSAVRLAEIYVEAGVPPGVFNVVIGGGEVGSALVSHPSVRKVSFTGSVPTGRKVYSTCAEQIKPATMELGGKSALIVFSDTDLHEAVSGAMLANWYSNGQVCSNGTRVFVHESIHDAFVDLLVKRTAALKIGPPLHADSQVGPMITTTHLDKVRSYIQIGIDEGATLAYGGTTPPDLTQGNYILPAIFTNCHDDMRIVQEEIFGMVACILPFRDEDEVISRANASPFGLSAGVFTNDMRRAHRVVHQLQVGTSWINTYNIAPVELPWGGVKASGIGRENGVAAAHAWTQLKSVYVEMDSVVPCPYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WFX9</accession>
    <name>A0A6G0WFX9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_016064</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000241">
        <property type="protein sequence ID" value="KAF0725501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WFX9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005422"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026248641" evidence="2">
        <location>
            <begin position="18"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0725501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="285" mass="31255" checksum="A94441519519EC3A" modified="2020-08-12" version="1">MFPLVVVLHLALSSVDAKLRATFPVSFPALSTDNPVCTFDIDQVRIRETQTDEDTSVRWENTISCKGPQGYAIRACQLKRCHCRKFHTRVKQTKITMWAECLPDIKETDECFGADMRWCDNPLRGKDPLSTDEKAVKLAADGKAAEEASKLADNSNTTAASDHAAGSDSFPVLAVVLASVGVLLAIVVGTWLATSKKKTKKTVVITTQATKDPQSLGFDDDDHHHKNLYTDAHSTAAVVHTVAEPRIRRTSSASVSSFVSSIHGDTFDFDDADKQQDSWIAFNTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WG59</accession>
    <name>A0A6G0WG59_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_015896</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="2"/>
    <dbReference type="EMBL" id="VJMJ01000235">
        <property type="protein sequence ID" value="KAF0725678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WG59"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine(46)-N7)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF23">
        <property type="entry name" value="PENTACOTRIPEPTIDE-REPEAT REGION OF PRORP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="repeat" description="PPR" evidence="8">
        <location>
            <begin position="120"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="8">
        <location>
            <begin position="155"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="298"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0725678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="634" mass="70271" checksum="067F14938D660967" modified="2020-08-12" version="1">MINMAGQQRGPRDKKPQQKTAHAGHSKAGDKGKPKHAKSHSQKPFKRPNSAPGKSPSAISTQKPHPKKRQAAHDNGARKKHKDNPETVEINQSIAQFASRKQFQEAQAAFDNAVARKLANSYTYVNMMNVCVRCGDMDQAWTVFSSMKEAGIKPDVVAYTTLLKGLCGEGQLTKAMEIVAEMEANKVPLNVRTVNTLLRGCILVGDVATAETIFDKTLGRWKLTPDASTWEYMIALLCRNLQLKKALNLFGKGILASGSQVSENSSTLLNLARAAMLLGDRDTAEKYIAMTRVCLEQEEKQPDDDKNAPVEEGGKRGRGTDSASRKESLAVFLKIKRADLRRELTAMEAYNHDTAALIDMFKKIFLLPLVQDDKPLATSCSMKVLDSMGLRALLKKHNMENNIEDKFSSRLREESNRLRLRKVFGKEAKAYPLKIEICSGAGEWIVSQAKKDPQARWMAMEIRHDRVYQVFTHAVFSGVDNLCIVGGDAAMAIRDHLETDLADFIFINQPEPPQQTGGAAATTQAKHLLTQPFLTNCVQLLKPGGRLTIVTDNKWYATLLLKTVAKLTDVEGVRLKKQQTVESIGAIHIYMGHPPKECGIADEHSSSYFDRLAKHDNIRASQGTYFLSIARASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WGK7</accession>
    <name>A0A6G0WGK7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_015389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000219">
        <property type="protein sequence ID" value="KAF0726273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WGK7"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0726273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="72" mass="8044" checksum="8249A3A024233E00" modified="2020-08-12" version="1">MCDEDICSALCCGALCSCCCAAAAEQDRRQYQQQPVIVQTVQPVMVQQPPHYHHHHGPPPPPQYGHPGPYYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WH46</accession>
    <name>A0A6G0WH46_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_015279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000215">
        <property type="protein sequence ID" value="KAF0726465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WH46"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0726465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="73" mass="8505" checksum="B2C9E58CB88C370A" modified="2020-08-12" version="1">MAPRKRSIYRWTWLRRPPQDSQVKLLFIHAIAVHFSTFWRFAQLMCGFGLWIRFPAASISIAMLMAASIYSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WH52</accession>
    <name>A0A6G0WH52_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_015297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000215">
        <property type="protein sequence ID" value="KAF0726483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WH52"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004624"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0726483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="171" mass="18560" checksum="E8A52090126CBD90" modified="2020-08-12" version="1">MGCSQSTLATEPEVVAPPVLVEVPASVPSSPVKQESAAAPEVNKVVDEPAAEVEEPQPEEEQQPEAEQQPEPTKAFVILEETIVISGVVHYIVQDASGQKIHKRYSAFKQLHDTLCKVEGCEGMPQAGVWTALQRTNQALVAGRRAKFEALMNEWAAIDANKEVLAAFMIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WHF3</accession>
    <name>A0A6G0WHF3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_015225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000213">
        <property type="protein sequence ID" value="KAF0726604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WHF3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000809"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006476">
        <property type="entry name" value="CHP01589_pln"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01589">
        <property type="entry name" value="A_thal_3526"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31871:SF1">
        <property type="entry name" value="HISTIDINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31871">
        <property type="entry name" value="OS02G0137100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09713">
        <property type="entry name" value="A_thal_3526"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0726604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="148" mass="16635" checksum="29896AB866885EC3" modified="2020-08-12" version="1">MSAPSDVPEMDAAGYNDDSTFSWNEILHVQNLIERCLQQSMSQNDIINALQAQANVDPNFTRTVWQKLEEQNPSFFEAYALHLTLKEQILTFNYLVSQQREMSEGGQPALMVESKSAAEIPRVMPSTSSMAPLLSPIKNELDTCAFFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WHU5</accession>
    <name>A0A6G0WHU5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Crinkler effector protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_015139</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Host cell</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000210">
        <property type="protein sequence ID" value="KAF0726743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WHU5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017914"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043657">
        <property type="term" value="C:host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045379">
        <property type="entry name" value="Crinkler_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20147">
        <property type="entry name" value="Crinkler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Crinkler effector protein N-terminal" evidence="4">
        <location>
            <begin position="2"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0726743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="400" mass="44778" checksum="976FEA15E96BB177" modified="2020-08-12" version="1">MLTVVCVVVGEGRPFSVKIEANEIVDELKDKIKEKKKMITCDADELELYLARNGLSRDEANAATLDEDGNVPGCIKMDELLRIQNDYHFGMNFQPEEGKIYVLVVVREVQKTKDKWTALELSTIAPEVQWKLWKSVVRVVISISSCVEDTGTALVVDRTPTHLYLLTNLHLFLDEEYSDGLSDDFTKEIQRYSKLHPGKKPSGKRKKDAANISAPSIRRSKRVKKVPVSSDNFQIAIEQLFPDEEELKEVYKFSLESSTCWRCSADFDFAIFEVPTPPNVQLELVRCKMAYRVFPTMPVHVFGFPGSLDGKFDHHYAIIPAEVTGTNRNQMTLSTLSAPGLSGSAIVCTKRGIPVGYMGGGFDGSSEQYQSYGFTLQGMPQDLPSALPLQDDEETKEEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WK48</accession>
    <name>A0A6G0WK48_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_014446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000193">
        <property type="protein sequence ID" value="KAF0727621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WK48"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020672"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0727621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="327" mass="35754" checksum="D875CED2AF4F721A" modified="2020-08-12" version="1">MEQYGRPTRKRSNAPVVAFLHPASSKPETQSPRASSVQSASSVPRQRPRAVNNDVQVPERSAAGFAAKTQGDDHRESIPVVHKVRPSTASAVKTSSLTYSKADNNDHNEADAASPSSPQQRTPRMIRPRTATATKSTLSHNRPPPQASLLPRTTNEERPDARNERPETVVAVETLADRAYMTHLREDIKCVQRLLGQMDDAPSDPKMSLTTKGDGQLASPQAMKAHLERMLSESLVLLMDRTLGNDNKEMANQDERGAGCGADGGTVYLSSFLGLARRAEMLQKKLVSAGVEKAFMEDELKLKESQLDTANEQLILFKDALAKARPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WKG0</accession>
    <name>A0A6G0WKG0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_014254</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000189">
        <property type="protein sequence ID" value="KAF0727738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WKG0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016490"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40866">
        <property type="entry name" value="BED-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40866:SF1">
        <property type="entry name" value="BED-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0727738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="144" mass="16597" checksum="0CC1BE4EAED30466" modified="2020-08-12" version="1">MDDYPSATSRLSPDADIVANPDFENGVVKILSQMTNILNESERRSVERLKIDAVAPNEVPIDRPCLAERAKKRMKKTGDDKQFMDCRFIRPTSNICERLFSMAKLALTDRRRAMHPQTFEQQVFLKVNMAYWGVDDVIEIMTEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WKR4</accession>
    <name>A0A6G0WKR4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HID1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_014209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000187">
        <property type="protein sequence ID" value="KAF0727870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WKR4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010993"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000138">
        <property type="term" value="C:Golgi trans cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026705">
        <property type="entry name" value="Hid-1/Ecm30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575:SF12">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09742">
        <property type="entry name" value="Dymeclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0727870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="734" mass="83546" checksum="98C9E5C475E85D77" modified="2020-08-12" version="1">MGNSDSKSKFRESVYKLSNQEVSSRQLDFWDKLWKIPTTAEEIFTLIQPDDIRMLRQNQQQNLSTMLTQAISQLHQIVATPLPKYYPQAVNCIRVLTRVMPFILEDRSDEFVQQLLWGPPPTTAAEEVVAENANTSEDNNSQLSLAQRLIDATMGLLFLPDFTVSAGAYKAYREQISPGAKVYPSLLWYNGVGYPDASAVTTVQYDKNRKEVLKLLLTCFSGILYHTADSCDSYIDPFLAYATRADTPFAPTLFYSLINVTLLYDPVGWGVPYAGSIVADEREHLVDISIQVLLVLLDFGAPAIKREDDNDASITTFESTNKYRELLSSIQREEDFELLFNGLAKLLNNYHQSMNTLLPNSIKQIKCHQELLVLLWKLLDENKAFLHYTLKRADMNRIVVPLLFLMYEGRKEPSKVGMIHICTFILLLLSGERDFAVNLNKSFDLKLPLDLPPFNGNHADLLIVCLHKVIVNGYEKLNSVYNCFLTIISNISPYIKKLNMVSSVRLLRLFKLFSQPRYLFDNEANHHLVFFLLDTFNNLIQYQYEGNEQLVYAMVQNKDLFQKLNTLSMPTVTPPAVTTPKPEQHDSLDDVDVVPSVAALTALNDAPIDEEEQTAPAPIPVKFTPTEEWLQSWKKKLPINTSLRLLQYLVPQLEDACERAGGSLDETAMLVFLRSTTMVGLLPVPHAIVIRKYQTNQFTNLWFTTFTWGVIFLRNQVFPLFDGSSITLFTINVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WLR5</accession>
    <name>A0A6G0WLR5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_013911</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000180">
        <property type="protein sequence ID" value="KAF0728260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WLR5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017356"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08252">
        <property type="entry name" value="AL_MDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014182">
        <property type="entry name" value="ADH_Zn_typ-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050700">
        <property type="entry name" value="YIM1/Zinc_Alcohol_DH_Fams"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02817">
        <property type="entry name" value="adh_fam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695:SF294">
        <property type="entry name" value="RETICULON-4-INTERACTING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="5">
        <location>
            <begin position="24"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0728260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="338" mass="36171" checksum="586E053B43B505D5" modified="2020-08-12" version="1">MLTIPKTMRAVGFHEPLPIDDPCSLLDLVVDVPTASGRELLIQVKANAVNPIDYKKRREPVHFTSPEDRTGPRVLGFDASGVVVAVGPDATLFKVGDEVYFAGPIVGLGSNAEYQAVDERVVGHKPSSLSFGEASGLPLTKDPSVNKPASQSVLVLNGAGGVGSIAIQLLKEMTDLTVIATASRPQSSAWLTELGADYVVNHAEDIPKQLAAIGHPHVDYILAYTELVPHFDAIAEVIKPRGKICAISPNDDNIPIQKLFLKSAGFYWLALGTRSIFNTGDLDEHHRILDEVSALVDAKRIRSIVGKDLGIMNAENLKMAHAALEGGHVIGKLVLTGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WME8</accession>
    <name>A0A6G0WME8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">mRNA export factor GLE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Nucleoporin GLE1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_013692</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GLE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000176">
        <property type="protein sequence ID" value="KAF0728506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WME8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010041"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.510">
        <property type="entry name" value="GLE1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012476">
        <property type="entry name" value="GLE1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038506">
        <property type="entry name" value="GLE1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12960">
        <property type="entry name" value="GLE-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12960:SF0">
        <property type="entry name" value="MRNA EXPORT FACTOR GLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07817">
        <property type="entry name" value="GLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="120"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="476"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="192"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="476"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="521"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0728506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="533" mass="58418" checksum="0669C5807809D3C0" modified="2020-08-12" version="1">MVRVRAPSVTDDDANSHVGVGIAASQIKTPSKWLGMSDCIDEPLTVQSVVAHCERGALQQPSKKLSWLSIQDPSVLKSKQLDIHDMATKLHSTTIQDLEKTKKSRDDLLSRIAQNVKRLEALAKATPPPEEETPTPTPLESPAKEPDVPKTLPPSPPTPSPAPAEKSASEAKPVTVTPPAPIPTPVSKPDSIQQFVNEAKQKIKALEQLQEAIKEVIDSKDLTVKRIRIDVKKKLGEACNQIANSPSSIKLVVGKICQVLSEAKVAGELYFKFSLDIVASKFAAQPRVITEVRSCFPVANVLTMCCVHTPELVDVFLAYLYKACPYTIPHEPKKAPDQSIDEYKLSIGMEYEEGSKTFEPHEKYILRMTMCVALLSSVMQTYPFDGKPQPQGLTLADCWTWIARIVNAEPNVLTSPILLAILETSGYQMFQTYKRQFGKLISLIQNTVVPSLSRDVKSGAAASLARLTTFLAQDEIKKEPEGRRPEETSVTLEDEERDANEGPSSGYGSRNLPPAFSGGRGRGRGRSGGRGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WN72</accession>
    <name>A0A6G0WN72_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcription and mRNA export factor ENY2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Enhancer of yellow 2 transcription factor homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_013386</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates histones. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2). Component of the SAGA transcription coactivator-HAT complex. Within the SAGA complex, participates to a subcomplex of SAGA called the DUB module (deubiquitination module).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
            <location evidence="1 11">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ENY2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000172">
        <property type="protein sequence ID" value="KAF0728816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WN72"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000462"/>
    <dbReference type="OrthoDB" id="6221744at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071819">
        <property type="term" value="C:DUBm complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070390">
        <property type="term" value="C:transcription export complex 2"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.140:FF:000001">
        <property type="entry name" value="Transcription and mRNA export factor ENY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03046">
        <property type="entry name" value="ENY2_Sus1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018783">
        <property type="entry name" value="TF_ENY2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038212">
        <property type="entry name" value="TF_EnY2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12514">
        <property type="entry name" value="ENHANCER OF YELLOW 2 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10163">
        <property type="entry name" value="EnY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0010">Activator</keyword>
    <keyword evidence="4 11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3 11" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 11" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0728816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="102" mass="11993" checksum="44DD6EC34B521029" modified="2020-08-12" version="1">MSEAYNHQRLRDEQVKETINQKLIESGEKERLKEILRQKLIECGWRDEMRAYCKDLIKTKGIDQITVDDLVEEITPKGRATVPDSIKADMLERIRLFLETTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WNG4</accession>
    <name>A0A6G0WNG4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_013433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000172">
        <property type="protein sequence ID" value="KAF0728864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010776"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021234"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="604"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="637"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="691"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="720"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="776"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1532"/>
            <end position="1552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1654"/>
            <end position="1673"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1717"/>
            <end position="1738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0728864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1832" mass="202157" checksum="30F96012FC51BB06" modified="2020-08-12" version="1">MDGPTLDTLLPAPAKHVASPQTSSRIQARIAVTTVGFLYMMLSVSCSSWYLTLVQPHVQSDIWWPDFNSTGVQTFLGDIVHSRLSLDANGTFDLASDRAALSKSYSGEDTVLTLPPTAPTKMLLANVPFDSAIMAMRDTTLDSFLGYRIPYCWIDFERAFELAHTARRQERCLRNDATNAAVYLDSFFRNVNSTALSKWSLLDQFNETVFLPLAAMSAKGSAWVDAVLQRAKLETVENEVAYWNSHGMARFTLQLRNGVTQQRLDNSIFIEDALGVQQLMTIYSVAAGASYSFGGTTFWASLSFSSEFNIAALLNCSVIRHTTNDADAMGLSWDTDILFPGVQGLPGTDLMRTHVGPFGSIDIRTVPVPSQLATYFLTFRQSLYDYMQQHPAGDREYSSLLEPTVDPTPPTWASMVFYGGNPMCPMGSPQPFIQPSFDVNDDCSNQVPYTIQLLRDNIFFALVTTGLTSPSDVCGLCSASSAACFPVLQAALPLATSWDRTTMFTQLNPPPLDVVSKLNISFMQFATAADGTQAMLAEPLVSPDRPSSSLWSFYGWVGIHDWLVGTREVYAFEGDISTLTVLTESQAVLSLEANELEIPRKACFYIWAITVYITFVLVGIVTLMILYAFVIGFHVEWWNLFLCNWVIGSVWVGRPILFLRGMTAMVLLSSASISFETHAGFSRLVLAPRSFFSTMVVAGEATWLTIVLHDLLLPFSDQNLTLHAPISTALVWFILAIIEYSKPHVATVALQRTCTYFELGVSGSCASAVVQFGSLWRLGCLCIVQLACIILVYGAVYFYDKNIRQGHRVVAFGVPHVLVPGIVHAFFIHSGHGDIYLDRVACAMCGMITYGNRLFHIPSWTMTTKESLHGVGYMFQVAKLSVPPPPNPQNDKGDDAATPSPEHKYIRWMGLIGLGHMIGSVAGSYGYLLSVQTVMANDLWWEHFNSTAHQTYLSNWFNRQLQVTPQLSATLATNPQYGELGSINDYSSEATSVLTPPLYTSAVQLEANTLANVITGLRQMSGCHVPWIATAYCYADFNRSWEMANTLARQQRCLAKEKQNGAVYLEAVLRNADWPSLLSCWNESLTIGVFSFMQTSNSGQRWLSSVQAAGGTNAVGDEVALWQSHGITEYVTQWQNYKELGIFETFSIANAFGFSYPMTIKRSRGSMRTTEASSMKMYWSFASDLWAVSTNTTAIGGCHLIRQSPSFAFANTSLADVMGQNGSLPWPLGRGLSLVEAELGPFGAIDMKRVACPSVLRQVYQNLTESLIVLVNVDSSSPSSDDWLLQKNTNHTQVVVDYMSLLQSNNAPFPLLAPAWDTTNVALCGGKLMCELSSCGGRLAQDFFSTSESCTEPFIPDAESPTKENVLKAMLAVDLRVMQTLATLEFACSCALTTTDSCDACVQMLRNSTDFLSRSFTPSAVASFRALAQTAETLVRDVLAIEMIQFTSDWLNGTIDPSTNVSLSRANLFADPRMGFSSWLYLFDWVENRREVVTFIGDHGAVTTMSDHSAVVLAPANPRELPLSFSFYSYRMSQYITGVLFAVACLVCLYIINSVGRIEGMNMMTFNQVAGLVWIGRPLILLRSLTAICCLATADLVMDASSFRLVARLKEVPSPWYTTFLSTAELNWLVYVLEDILSVVTTRRTFESTIENPVLSAFITSFLTQSTMLSWTISGTWSAVNPVQHSVTLDRKCELPNVDLDIACNSGTLVYGSVSRFVSLVILAAACAVGAFGLKLLLLRASATPRKVYSAFLPAVAQNSFNFSKWEVQDMYYLDKPSAILAGILVFESGHTYYAFDVKNWRCFAIDAKAPRKMMEGVAQMQHLYHALPLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WP02</accession>
    <name>A0A6G0WP02_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Crinkler effector protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_013206</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Host cell</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000169">
        <property type="protein sequence ID" value="KAF0729069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WP02"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014598"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043657">
        <property type="term" value="C:host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045379">
        <property type="entry name" value="Crinkler_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20147">
        <property type="entry name" value="Crinkler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Crinkler effector protein N-terminal" evidence="4">
        <location>
            <begin position="4"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0729069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="610" mass="69287" checksum="77FCC577D16141A8" modified="2020-08-12" version="1">MPILFCLVVGKGTSFPVHIDANKYVDHLKNKIKEENSNSLKCDARELLLYLALKDKVWIESTSPLVERLMKGETPDEIHEYLVQTNKMSPFSTLDEALTLPLGRNEIHVLVVVPERQVDSLPKKKQRLDGRVFFSLEGIQAVDPASCQPNVWLDCQEISKVTAFPADYFVRNESIDVFHLLKARTTRQIVLEGSPGVGKSLLLVLTSFWMAIEGKKCVVLVRLVEGKGLSLIFLNGQNLSDNWKLERMSADEIAPLVQQCMRRFPKCELCLDGFQQSFLKNHMGVLMAFSVLAASGPYKTKQDDAGILDLCLVPFWSFSDLKLVGQHYTWDDESMEKKYYFSGGSLRLFLVSEMDAKIAAELAFCKVDLASVKLLNTQNGSRFDKQIGWIQMATLDTSDLSNYNRPGKWSYVVCSGFALRKLGDRVTLEYYKDLCHKAYMINDVGLFGIAFENYFHAMAREKQSIQLKVREYDSTKPREYSVLTFTSAKHLLKGKDQTDFEKAMKTWPSELDYWYPDSRCPIDSIAKLDGEYLLLQLTRSTTPSIDTEYLETISKCFPPNSSIAYMAVVPNKAICDEFRLSPADPVTQFPLRVAYVDDDFFTKFGNSMEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WP58</accession>
    <name>A0A6G0WP58_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_013153</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000167">
        <property type="protein sequence ID" value="KAF0729176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WP58"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020285"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="27"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0729176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="134" mass="15081" checksum="7C9F3EC50F670C9F" modified="2020-08-12" version="1">MREPTQAVGRRHDYHAHLGGIGHQVPHLVIRAIGHGAYVVSIATVDQTTGNAVVIKTIPKTSDDLVDAKRIVGEICLMRHLGPHIVQGLDYMRPPAIGKFEDTYIVTDLMETDLHRVIQWREHLDAQRIAYITY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WQW9</accession>
    <name>A0A6G0WQW9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_012699</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000161">
        <property type="protein sequence ID" value="KAF0729811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WQW9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006893"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026259059" evidence="2">
        <location>
            <begin position="17"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0729811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="130" mass="14368" checksum="D7A75E82C1B56A0E" modified="2020-08-12" version="1">MKYIALLFVFFVTVQGCLIHLLDCMTSCGANQEVAQSVECIESVACYDNCYTNMTNRVNSGQCSRFDDDYPTLPPETEAPTTEAPTTAAPTTTARPTTRKTITLPPKITFSRSETSKKTAKPTTTRTHFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WRG5</accession>
    <name>A0A6G0WRG5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Temptin Cys/Cys disulfide domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_012428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000157">
        <property type="protein sequence ID" value="KAF0730029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WRG5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014001"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057626">
        <property type="entry name" value="S-S_Temptin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055313">
        <property type="entry name" value="Temptin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34737">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34737:SF2">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24784">
        <property type="entry name" value="Temptin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Temptin Cys/Cys disulfide" evidence="1">
        <location>
            <begin position="12"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0730029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="126" mass="13642" checksum="36FC879F4914EDBB" modified="2020-08-12" version="1">MASRAVLIAAVVQAYSEFRYKIPNGFEVKDVPAVGHANKLGGGNDLANFGVDFIDAGYTWTKELCEKDSDGDGATNGEELGDPCCLWNEIEDDTPLRQSDLTSPGHADVFTPEQLAAIRCTVKYDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WRJ0</accession>
    <name>A0A6G0WRJ0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RxLR effector protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_012386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000156">
        <property type="protein sequence ID" value="KAF0730090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WRJ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017260"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026145058" description="RxLR effector protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0730090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="119" mass="13268" checksum="33082B814AE85F7A" modified="2020-08-12" version="1">MSKLIRIVLLLALFLVQTTMAFIPQHLQLQREMVPYVHQNEQGQLVEETVERITATDPDDKSPTAKRPAKRQFFFAAIGAIARVASTAARVAKAGVKVAKGVNHARNANNDRKNHKKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WSW6</accession>
    <name>A0A6G0WSW6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_012008</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000153">
        <property type="protein sequence ID" value="KAF0730588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WSW6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002362"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23812">
        <property type="entry name" value="UBCc_ScPEX4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="3"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0730588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="159" mass="17918" checksum="52346683E7597587" modified="2020-08-12" version="1">MNTNVKRLRKELTELRKSPEADMVLHPLEDTVTEWKAFIKGPVDTPFQNRVFELRIVTTPLYPMEPPKMRFVTKIFHPNVHFTDGSICLDILKREWSPAWTLRAACLAVTSLLSDPAADSPLNCDAGNMIRAGDMLAYNSMAAMYTEEFGLPALPPTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WTT2</accession>
    <name>A0A6G0WTT2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_011805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000149">
        <property type="protein sequence ID" value="KAF0730923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WTT2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016488"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0730923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="219" mass="25491" checksum="F7B2C9E26A5774F1" modified="2020-08-12" version="1">MTKVHATRPNEPTVRLSRWSVAYNVAFVVNLATTPFMAYLTEPLPGRIAQVHVPEWNSFQEYTDVMATYFHTLFNNTTMPYEVVKQDRTTNTFAERVTMEIPFSIPESQVQGYISHMAGSPYFAEGVEAYMTTFLTSNASSRAAIKPWRICQHQCLVGINFGEFCYWLDEVEDGANSPRYEVWAVNYPSETPQISWFKFIFRSVVSTYVLRVFWTRYYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WU54</accession>
    <name>A0A6G0WU54_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Hexose transporter 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ae201684_011537</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-fructose(out) = D-fructose(in)</text>
            <dbReference type="Rhea" id="RHEA:60372"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:60373"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>D-galactose(in) = D-galactose(out)</text>
            <dbReference type="Rhea" id="RHEA:34915"/>
            <dbReference type="ChEBI" id="CHEBI:4139"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="7">
            <dbReference type="Rhea" id="RHEA:34917"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-glucosamine(out) = D-glucosamine(in)</text>
            <dbReference type="Rhea" id="RHEA:78423"/>
            <dbReference type="ChEBI" id="CHEBI:58723"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:78424"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-glucose(out) = D-glucose(in)</text>
            <dbReference type="Rhea" id="RHEA:60376"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:60377"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-mannose(out) = D-mannose(in)</text>
            <dbReference type="Rhea" id="RHEA:78391"/>
            <dbReference type="ChEBI" id="CHEBI:4208"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:78392"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-xylose(out) = D-xylose(in)</text>
            <dbReference type="Rhea" id="RHEA:78427"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:78428"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000147">
        <property type="protein sequence ID" value="KAF0730985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WU54"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015202"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="387"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="419"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="16">
        <location>
            <begin position="39"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF0730985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="514" mass="57072" checksum="22A58F5065822602" modified="2020-08-12" version="1">MNARTTSLQDESSSSGEPYESITKNHDSELASSPLMRKSITAALVGAMQFGWMSGEMGYLPFHNSQYCAMPEIPAGQCILFPGHTTAEWTMQATALAVGGAIGALLSAYPADKYGRKRTLGWNGIIMIVGGLIQLISADIYTFAIGRGINGIACGIAVNVITNYLREISPIPWHVFYVTMFQIASTFGSLIVTTLMYAISHVPNEWEYKYFFGGPILLGLIQIVVMRYIIESPTWLIQTQQIEESRQAMNQLYMPGDVESHWMTKVESVGRQAQEIQSSSSKLGLLLSRKYSKQFLIAITLATMVQLCGLSALVAYGPQIFQGIGIRELRLSGTLTNFSRLDYMYLAARYSSKFSRRSLFLVGSVGCVLGAMGFTFCQMYPNETTKWLQLVCFMIFIFSFCFSVGSLGWLVATELVPEALGATSGSISTFFTWVAQFFIGVYFQQISNTKHWGTQAFFIFAVVNLIFFFFVLAFVRDTNNKSTDEVTAIFSPEVNAIDDTDNTFNTSVRTPVME</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WUC2</accession>
    <name>A0A6G0WUC2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_011611</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000147">
        <property type="protein sequence ID" value="KAF0731063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WUC2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019594"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039663">
        <property type="entry name" value="AIP/AIPL1/TTC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11242">
        <property type="entry name" value="ARYL HYDROCARBON RECEPTOR INTERACTING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11242:SF0">
        <property type="entry name" value="TPR_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0731063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="265" mass="29593" checksum="9098A843654FDDC5" modified="2020-08-12" version="1">MVEHGEAYTVSKMLNSINETMGGAGSVQLKRNVGNGIALDTSAKDIAFLDTQAKIKTSVERVAAMGAKEKREWVAQRRAKGNELFHQGLYREASDTYLEALTGLNLSQPGDDHEIQQAITCNIAACLLKLQEWEKVVKMTTVVLTSQPTHIKALLQRSKAYMKLEEFEKSSADATKAQALDVADPSIPKQLECIHRAQLCSQRQRREKKAFEKSMMKKMGSLYADKKDLVQNESPRVNGWRAAIESIVRALIRAISWCVGKRKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WV58</accession>
    <name>A0A6G0WV58_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_011311</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000143">
        <property type="protein sequence ID" value="KAF0731408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WV58"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019269"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564:SF1">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0731408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="238" mass="28129" checksum="7E76F7FD4008EF9D" modified="2020-08-12" version="1">MSSIEYIVGRHASPNTVMHCLYGYFFLGMKRSQLAIIYRKDEKTISNWIQRYNDTGSYSRKCSSTLRTFSQVEKQWILEYYRKNPLAFLDEARSAFVQMFKRSISVSHIWTIIHQHGMTWKVIERRVIHIKQQDITRFVQEMDGICWSQRNIVFLDEVSFDNRGMLRKRGYSMRGEKIVYRGEFNRKPRVSLLCFVGADGIIDYFDTMGTFDRETFLQCCKSFSQSGKVAMYPTKNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WWF3</accession>
    <name>A0A6G0WWF3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_011117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000140">
        <property type="protein sequence ID" value="KAF0731819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WWF3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010540"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027625">
        <property type="entry name" value="OvoA_Cterm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04345">
        <property type="entry name" value="ovoA_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45445">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45445:SF2">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="1">
        <location>
            <begin position="98"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0731819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="293" mass="33519" checksum="A12B7901706E83E2" modified="2020-08-12" version="1">MEVQGRSLLTSSFAHLRRSMHRALLTTVRKMSTRSTTASGSMVYESERAAHEYLQFHFGDSSEVVPYPFAPADALQFLPRCVNDTIVHTKPEQRQRALEIGCAVGRSSFELSRHFDEVIGIDFSQHFIDMANVMKEKGSAPYEAMIHGDIKQTRMARVADDIDRSKVHFEQGDACALGTHLGEFDVVFASNLLCRLPEPKRFLDRLPTLVRPNGVLALISPYSWLEEYTPKEHWIGGTVNSNGIPVDSFSEIQRILSPHFELVERTQYPFMIREHDRKFQWGVSDGTFWRRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WX54</accession>
    <name>A0A6G0WX54_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cation/H+ exchanger transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ae201684_010733</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000137">
        <property type="protein sequence ID" value="KAF0732080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WX54"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001043"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045158">
        <property type="entry name" value="KEA4/5/6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16254">
        <property type="entry name" value="POTASSIUM/PROTON ANTIPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16254:SF14">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026305516" description="Cation/H+ exchanger transmembrane domain-containing protein" evidence="12">
        <location>
            <begin position="20"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="453"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="507"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="532"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="13">
        <location>
            <begin position="249"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="637"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="158"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="647"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF0732080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="656" mass="72373" checksum="1CE8F3210C8DD4F0" modified="2020-08-12" version="1">MGTCLLLTLLLYLFPIAHSTENIPATLVYSIQSTERTEVSDTRNPETPTMLVVAKTLTRYLQPLTTGRARNIEAQTSKVTAETPSHSGLSHLEEQLHLMEQLEASVIARINSMDQQLSEEKGKRPYDSLQALLANDLKEVRVNLHKLAANLNLTMNDLDTVEKDTEEKEKKLEEVLKKQEAEENAHELEERGAAAVDYESGRLKNISTMEVMSDEQRQHFEKVKNEADPAVLHYDFGLLGQIALLFGVSAVGGIVSTSINLPPTVGYLVGGAIVGPSGLGVVHHFKEVETISLFGTIFLLFAHGAEYSLHRSDEVFKLYLISGILYVACTIVSVSLLAVTLGWTPSISEGIIVGAGVCFTSTAPLSEYIRHYNFRQTSFGRLVSAIIAIQDILMSFVLATPEWFAAKSGWITISVIKTFVAYAAVVVFTIAMHRYVVPSLLEFLVSMEKLHQAPLVLLGIVSVCLFMSLFTETVGLSLECGAFFAGLAFQGSSNLKATLSSIRVLDNLFGSMFFACIGMILNPAFFLRNCGIVFAMMICVCMIKVTLVTSIMSFFQIPFQKSIKAALSLCQVGEVALIFMIKAHATQLVSRPMYLQFLAATSIFLGLSPVLHRNLNEQNTFHFASVLKEKSEFEDDESGHEMLPSSNHKRHNIEHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WXJ3</accession>
    <name>A0A6G0WXJ3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_010660</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM U1 A/B'' family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000136">
        <property type="protein sequence ID" value="KAF0732215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WXJ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010697"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030532">
        <property type="term" value="C:small nuclear ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12246">
        <property type="entry name" value="RRM1_U1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12247">
        <property type="entry name" value="RRM2_U1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000039">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000029">
        <property type="entry name" value="U2 small nuclear ribonucleoprotein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10501">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="18"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="150"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="103"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0732215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="224" mass="25263" checksum="4CEB2DC8322F2D75" modified="2020-08-12" version="1">MESKPMTNTAAADAPPNETLYVRNLDDKIKEPRMKESLYGLFSAHGKVLQVLLMKAHRLRGQAWVTFEDIASASTALRALDGTMHFGKAMNVQFAKEKNDLIRMQEPNAKPREKRKWDQLKAATKPKKTDKPAPAKVQHHQTQTVVLPHKILFLQDVPEACNQEALSILFKQYHGFKEVRMVPGKKGLAFVEFLDEVQASIALQGLNGFKLSADERLKVSFAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WXL0</accession>
    <name>A0A6G0WXL0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Deacetylase sirtuin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_010566</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000135">
        <property type="protein sequence ID" value="KAF0732275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WXL0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000326"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48252">
        <property type="entry name" value="HISTONE DEACETYLASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48252:SF77">
        <property type="entry name" value="HISTONE DEACETYLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0732275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="312" mass="35259" checksum="02ABFF1FBAB091D1" modified="2020-08-12" version="1">MRCAQHLVADSGLPVYNDIAKVDAYKALDVEYHDLCQPYLVHVNPPIFYGFWGDCFNMYRDTAGHPGYEILQAWKERLCAKGDTLSPLMDELKQAQFPDLHGATTDPFFVYTSNVDAHFLRYFGTHEVYEIHGNTETWQCAGQGEGTEPCEGTWNIPADFRFPVNKTTMLYDEISPPPPFLRCPKCNAPGRPNVLMFGDQQWLLNREDERRYVVWEASVEEALRRDSSKRLVILEIGCGLRVPSVRMECQMVLADIQAKTEPNKQVQLIRINPIDDDDNRGGDALLKINSTGLAALQEIASYMATTAASSDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WYA9</accession>
    <name>A0A6G0WYA9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_010397</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000131">
        <property type="protein sequence ID" value="KAF0732500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WYA9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021593"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000029">
        <property type="entry name" value="Heat shock protein 110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF28">
        <property type="entry name" value="HEAT SHOCK PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="576"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="610"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="460"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0732500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="673" mass="74876" checksum="5A25136C6AFA9E57" modified="2020-08-12" version="1">MEFIGLDIGSQRCVVARPSGEIVLNELGGMTTATLVSFKDKERLLGEAAVLASSTNPTNMIDYLNLLLGKTYDQAAAQLERFPSQRATIKTDEQGDPVVEIQYNNDTTHFTPVQLMAMLLGKIGRNVHPSPSTLKLGVAIPNDWDVAEKSALLRAAKIAGFGETVLIPRDHALARCYHAKHPIKDESIKTIVIVDVGHASTCAAVVQFSASGENILARAYDGHLGSVNYDRHLYEHFRAKLKASHGIDVKPASRQSRRLLTACEQLKKLLSTIPEAMVHVENLVPDSDITLSITKAEFEQLCAEESASLRKLLTSLLTQADISASDISVVEIVGGGTRKPAVQDAIVQAIGSHITLGRMLDSATAVALGAAFAQDVGTTLEEIAAVDLTNEIELELAMQRQDDMMRQLANKRNEIETFVYEIRGKRDQKHGNLIDFNVVNPYLDAAEDWFYSEEAEAATLEEATERVHALKSDIMNACKAYFDAVAKDEKELEEQLERESAKAALENKDDDDHDFRKLKTPDRMRLVVKNKDEGNELFRGGNIQHAAARYVKALTHASKFFDLRPEEADQVKAIKLSLYLNLAQCYLKLESWQKAVVNCKDALDLDPTNTKALYRRAVGYEKLKDFESAFQDIQEAFRLNPDDKAIVVLNDRLKAYMKKQQDKEKKMWTKAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WZB4</accession>
    <name>A0A6G0WZB4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_010173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000128">
        <property type="protein sequence ID" value="KAF0732844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WZB4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018693"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="578"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="650"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="653"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0732844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="672" mass="76536" checksum="74AFCD50ED7BB11C" modified="2020-08-12" version="1">MSSVASYSAETNVSVTDFSVQTLINAGLDISVSVPVQFAFICAVTVFVLCFEYVLETIESVIARHPTYWTLLNKMYRELLVGGLTAFVAKRIDQWDALPKYSQTKLNNSDDMVLYFSLSIALQSAFIFTMLRVRNKKLDKLSVLSARDLLEYMSTDDNANPTSKLSQSIMKTKILQNFFLTTYKLPDVFSFPKYLRSIQDSEIFSLFDVEIIEWLLLVAIYTAFFWIADVFETIRFVGEGSEDALIESGVGLQHAKMIQTTRLEVLLVFILILTVSLWALYAYVRRRVHDIVIHAGNGHESYLEALHEIADQEDARLAKPMTNDEAIATMMELADALSDVEDHSTIWDLIKSGARRVLGKSHVKNQAFVPVADLHLRFFSRKAVHVFAKLLMSFNAMYFALVWSAFNASVGRVISSKQAWWYPLCLVGLMVVLVFNMVFFAPRLVRQLALVNATVRVNPHELKAVIEHFSDVLEMQTEMAEAIVDHCDAHGKDIKELEQDIIAIDAQTTGYIEVEALRDVISRYGFKFSANKFQTFVRLQFKTRGTRVPYADFCRVFYGLTEQLKSHHDIVSEVMTTVSKHQPGHKASQHHRSKPHHHHRQHPRSFKRGRSSESFHNVLNNSMSSRSVRRPNHALLHNLSAFQRVNAEDDVESSSQVYQQVQTPKKTEVASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WZC9</accession>
    <name>A0A6G0WZC9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Casein kinase I</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ae201684_010032</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="VJMJ01000127">
        <property type="protein sequence ID" value="KAF0732923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WZC9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007281"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14125">
        <property type="entry name" value="STKc_CK1_delta_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000159">
        <property type="entry name" value="Casein kinase I hhp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="17"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="309"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="354"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF0732923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="448" mass="51098" checksum="8946EAD71AD82F7F" modified="2020-08-12" version="1">MASQRESSLELRVGKKFRLGRKIGSGSFGDIYLGTNMTSGEEVAIKLESVKSKHPQLLYESKIYKILNGGLGIPNIRWFGVEGEYNVMVIDLLGPSLENLFDYCGRRFQLKTVLMIADQLICRLEYCHSKNFIHRDVKPDNFLIGLGKRAQICHVIDFGLAKKYRDPKTHQHIPYRENKNLTGTARYVSINTHIGIEQSRRDDLESLGYVFMYFIRGSLPWQGLKANTKKQKYERIMEKKMNTPIEVLCKGYPAEFRAYFEYCRALRFDDKPDYAYLKRLFKELFFRKGFQFDAMFDWTVLNLQNGRRERDGSASASGAPVPAPAPPVINSSPAGAQMSNPMGASMAMNSAPMEDPHSARFDSRQDSREYRTGSSNRLYVREDSKESGDANLQEMQRIQDLRLQQGNGVSGGYLNPTGARDDRLYANQRVQSGADFGDAKVSLQRQRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X001</accession>
    <name>A0A6G0X001_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_010018</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000126">
        <property type="protein sequence ID" value="KAF0733202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X001"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012801"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0733202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="33266" checksum="ADAFD05D0E5DEF4C" modified="2020-08-12" version="1">MTTLLVLELTGATVAGGHSKGYPLAWLRYNGEERMAQGEWASDGQASWADDQRVMTFPKLDTVSPPVEFILSTIEPHRATYIGSQTIQLQEGEHHLDLPNGTLHVKMRVEAKKEIDEGGFSIKWTASDALKLEQARKAEQNKLMQAELSAMICEAKDRQAKRALYLKEKEDRRKFVAAVIRLQAHWRGIRVRTTLPLIRQQVERERRKLLAKRNVRERARRRRETEIQFLQTATHKSLPKQNHTAKVPMSSKTEIKPVETPEKLIDDELIHAIRLVHGSKWANSKQMQST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X0N2</accession>
    <name>A0A6G0X0N2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Anaphase-promoting complex subunit 4-like WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_009678</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000122">
        <property type="protein sequence ID" value="KAF0733432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X0N2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001784"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044285">
        <property type="entry name" value="PWP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="6">
        <location>
            <begin position="241"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="241"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="370"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="31"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="36"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0733432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="510" mass="55758" checksum="195641FE1C72E026" modified="2020-08-12" version="1">MISALAWVPRGASKRLPDKFVLSKEEVEMMTQLAQEEVDDEEANAEEDEEEEANDEEAGEDTNMEDDEGLKEFNMDQYDEEDDEAAVKDYLNGGADIEDIAEDEDEAFPDEDDEDKADMEIRPTDAVVMVCNTEEDFSNLEIHVFEEDTGNLYVHHEINLPAFPLALAWMDIAPLPPVNGQPVNGSFVAVGTFKSGIEIWNLDVLDVLEPTATLGGEANSTFRDVAISKAMRKKHKAALKPGSHQDAVLGLDWNAGHRNMLASASADASVKIWDVTTQQCMHTMTHHGDKVQSVKWNPVESTVLASASFDRSLIVLDGRAPQAFSKFALSADVESMTWHPHTPSTLVASTEDGIVVGYDVRTNAAPLFRFQAHDTAVSAISFSAAIPGLFATASTDKHVKIWDLQGTPVCVASKDMQVGELLTMQFYRDSPFLLGVGGTGGVLALWDTSENDTVERKFATRAANIGHHEVASSVNFSASFKSADDVAEELLREEEASVATTSKKKKKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X208</accession>
    <name>A0A6G0X208_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_009475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000119">
        <property type="protein sequence ID" value="KAF0733918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X208"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001700"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050754">
        <property type="entry name" value="FKBP4/5/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46512">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="118"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0733918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="189" mass="21702" checksum="537144DCFB7A93F9" modified="2020-08-12" version="1">MSTNDDSTVPLAAKSEKDHAFDFEERVGDARQCKVYGADAHKAKDFKRAIELYERALYHAEFDNLTWEHEFEEHHRNTVCQVRLPIYLNLAACFLAQDDAQRARDTCDLALKIDSNNVKALYRKGQALLILDDPEEASKLLKKAAELNPQDKAIRQAWNKCKEKLQILRQEQKKRLGGFLVGKDIAEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X3H4</accession>
    <name>A0A6G0X3H4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_008910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000114">
        <property type="protein sequence ID" value="KAF0734450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X3H4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011018"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00177">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051213">
        <property type="entry name" value="START_lipid_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308">
        <property type="entry name" value="PHOSPHATIDYLCHOLINE TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308:SF14">
        <property type="entry name" value="START DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00234">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="START" evidence="1">
        <location>
            <begin position="31"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0734450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="245" mass="27310" checksum="022AD0259D42C098" modified="2020-08-12" version="1">MPKKCTNYASFGAKNVDLLLARHRGVDGTHWTKVQYVDSITVSRGIVPGSKWYCMKASGRINCAAMHLANKLNDPSQMKIFDDMTYTCRVLKDVDGDKHTTVRHVQTKPIYPAEARDVVVVTTVEHFTDGIVIATRSVDHDEELFPEQKNVVRAKVLIGGYIICPISELQCEVNFLIHIDCGGRLPALVLNSLSLDYPVALIMRLQALYDVVPYSANTLVKHDVLLHHGIEVAHVVSQAHQVVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X3Q1</accession>
    <name>A0A6G0X3Q1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_008802</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000111">
        <property type="protein sequence ID" value="KAF0734560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X3Q1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000543"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000544"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF15">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0734560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="35534" checksum="2A62AC89D478BF2A" modified="2020-08-12" version="1">MHHRSLRSTMASGVLRSVRRYTAGAGLTAEQKASYEANGFLHIRGALAPEVCDALRARSDYHLSQFDPNAYQKSIFSSTHQTRFSDSYFLESGHQIRYFFEEKAFDDQGNLKQPVEKSINKIGHNLHSLDPAFRAISFSSDVVAILKSLGYVAPVVPQSMYIFKQPSIGGEVLPHQDGTYLYTEPQSVIGFWWALEDCTTTNGCLYGVAGSHKTTPIKQRFLRTTPFDGQLTADGDKPLLETVPSGPVDFDISKGEPILTKKGDLVLLHSSFVHYSHANTSLASRHAYSIHVVESHNTAYPATNWLQFPKGMAFPAVYQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X5K1</accession>
    <name>A0A6G0X5K1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_008297</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000101">
        <property type="protein sequence ID" value="KAF0735084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X5K1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015919"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045595">
        <property type="term" value="P:regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000286">
        <property type="entry name" value="PH-protein kinase domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039680">
        <property type="entry name" value="PLEKHB1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14309">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14309:SF10">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="117"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="253"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="456"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="41"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0735084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="572" mass="64047" checksum="9D3694163F1AE223" modified="2020-08-12" version="1">MAAVLATPGHIAMRGSQVGNEDMALIDEILSERSMFSAKSMGKMDSVTSPSPLDLTDSSSADDTPRSQLTHPTLNMLQSSSMSSFDSTRGGTTQDAPLVIPELEIESESSVEPVPKFLIRKGWIEKCGHTFKTWKWRYFELTRDGCLRYYTSEDKSVCKGMIHVEKTTKNDIVIQTHMSSREFFFVLSTPSRNYLFSTSTERTMKRWIRALESTGAHAGPGRWDPLRNTVHLTVDDDNKAHKWKGYEDPQDEQALMAGYLLKRGHVRTNWVQRFFRIEMADNHPMLRYYDDDRVTAKGSISLVNAYLSPGAPFSPDGRRNYFMLYCGTHELHLNALSEGDMRRWVHALAKAIVYRVHNPSAPPLPIQAAAAQATKIALGLPRVEIEFPSKESFETVLMERRSEALVVSQVSSLFPTLPLGAQLIRVNGTSIGLTLDAARLQLAQSAYPMVCEFICAPTKRGEMIKRSRSPRTLTSWKIREIVVEHGTLSILAWHEVRDSFSLTGCYLQILDIPGHPFCIAIGRSPAPADKLVLQASSLEDQMVWAATIHCSILMASQGLNVSGFDSHQLFFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X7Y0</accession>
    <name>A0A6G0X7Y0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_007641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000090">
        <property type="protein sequence ID" value="KAF0736054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X7Y0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002108"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0736054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="146" mass="16997" checksum="7B5A0F5051322E9D" modified="2020-08-12" version="1">MNYDLDLDSFLPQTIDLPWESMQEAAVDSAATEDTTSDEPPPPHTKKCKTATGTLPKSGRRPVEALRRQELADLKQQVRHFESQLEAMRVYELLDKHVPRWKKIARHQRNQVRKALEERKHLQQAIDANLSFIAHMSSQIRRKFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X858</accession>
    <name>A0A6G0X858_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_007629</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000090">
        <property type="protein sequence ID" value="KAF0736041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X858"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001867"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0736041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="127" mass="13951" checksum="71BC4050E2CA63B6" modified="2020-08-12" version="1">MIVQRSELEDASIPAMASGVVINESVWFTVEPVGTSMCRLKYLVRLVFDANNSPIGKFESSIDVSAQSLDAVKLDQTLSDSSLFASPSYIPQAIQHFPGFAPFVYQSIQLKAALRATVFGAMREFQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X8D4</accession>
    <name>A0A6G0X8D4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_007311</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X8D4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004387"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19076">
        <property type="entry name" value="AKR_AKR13A_13D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF40">
        <property type="entry name" value="ALDO-KETO REDUCTASE YAKC [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="25"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0736290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="343" mass="37776" checksum="18F211C3CAEF1B94" modified="2020-08-12" version="1">MVQVPQRPLGSQGLVCSAQGLGCMGMTAFYGNFDRAAQEEESLRTISKALELGINMLDTAWIYQSFGAGGGGNFTNEELVGKAIKQHGREKFVIATKFGNVIQDGQLKPCGKEETIRSQLADSLERLGTDYIDLYYMHRMDPTTPIEETMAVLKSLVEDGKIKYIGLSECTPDELRRAHAVHPITAIQMEWSLQSRDLEEAVVPTARELGVGIVAYSPLCRGFLTDIDTFDKLEENDWRRTLPRYSGEKLAESKAKVARFFDIAKAKGCTPAQLALAWVHAQGHDVFPIPGTKSSTRIVENAQAVAIELSQAEVKEIAAAAESVEGPRYAGEDRTFNARMKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XA89</accession>
    <name>A0A6G0XA89_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_006845</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000085">
        <property type="protein sequence ID" value="KAF0737035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XA89"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001892"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="6">
        <location>
            <begin position="96"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0737035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="410" mass="44384" checksum="041732B3CCCA7BFE" modified="2020-08-12" version="1">MLSLRHAGRRLPVLSRALSHQASRAVSATTSTSSHESTAFSPEWGWMGMAAIVSTLGAASAACKAQPEPAKEVEHDVVLDHEAKGVFSTPIAGIKSYSCASYKANLPIEDRFAVHADKHTVYAAIFDGHGGWQVAEYAQNHLIENAKAELAKESAQTVTKIESALEQAFLRTDFDLKEIVRGAFQLGFGQVNRVGACSMLAYVTDNLLVIANAGDERAVLGSFENDNLIAIPMSNDHNAKLPVEMARLAREHPGEDNIVVCKHPESCYVKGGLQPTRALGDFAFKDVDFNAPAAPTRRGGGRHIAPPYTPPYVLAKPEVQTHTVTGADKFLILGSDGVWDFLTNQEAVEIVHHYVSRGEAHLASRAVVELVLAKVAEVRGMDIEDLLEVAPGKPRRRLHDDTTVVVLVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XAC1</accession>
    <name>A0A6G0XAC1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_006876</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000085">
        <property type="protein sequence ID" value="KAF0737072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XAC1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021146"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF11">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="60"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="147"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="237"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="313"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="313"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="350"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0737072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="366" mass="40716" checksum="B8D1D8DCD0F7DD9E" modified="2020-08-12" version="1">MFRVASRVCRQVLPQLASKASLTAPAFQAVQARFVPRFANPSFAASLSLPRFFSSEAQNSTVFVGGLPFETTEDQLRDVFEKYGEITNIQFMKQRNGRFNGKALVSYSEPSEAKDALVLDGEELGSRWMKVAMAVARERTARPDDCLAVRASNLPFNITEEQVRSMFEHCGEISHIFFPKDHDTGRLMGYAFVEFIDPSSVDKAIDVSGVEAFGRRVNVVYSTARKPQGAHKPEGTKSVFVGNLSEEVNSGMLQDLFARCGEIESVRLATDRETGEPRGFAYVNFADTEAVDDAIKLAGTTLEGQAIRVAFVRPRDQANRRQRDDHHGSNSRGFGRTNGERGYGGRGKRGGRDEGRFDRHHHDSDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XC67</accession>
    <name>A0A6G0XC67_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_006265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000081">
        <property type="protein sequence ID" value="KAF0737771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XC67"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002367"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22538">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22538:SF1">
        <property type="entry name" value="VWFD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0737771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="560" mass="59266" checksum="C6F94D177EBCBA3D" modified="2020-08-12" version="1">MAIVDEQPNEIAENFTAIPDSPVVESVVEAKPRRVTRFRLAVAIAAVCGLVCVVVGAVFITKKHDKIDTKSIVNNIQQTPGLKVTVKALRSSMAINGKNEATVFIVPRTSENASSSLAFDAILTQEGENATATYVLLGNRGYWSISSGGIQTSAGCLYASQVPPVHLIQSSLEASREVDSVLVNGTAVPMNCETGQLLELQFAGETFVFCNSNANQLSHAKGTDLEITVEYLNDPTLVPDIAAPEVSTECAYIDTTLPTTARRLTAASASASTAATLSSSSCGCQGKVKPCLFVHGVGVKASSALTSTYSDYWGSIEKNAPCCSTTQFAHFDTVSRGWEDASLQQEFCNAALQVAANNQGKTVGDLILVTHSMANMFASSAVANNKCQFSTGVSWVSLSGPMQGSKSANLLVEKCTSGTWSDLALKGILDIVGYCPPQPAYLSLLHQSTVDSNTQSQFASIQSTRAQHVTKLVCGTSPIGLITIDSALEVVSALSHHDSANDGVVDINSCQAGYGTSGFGTSYSSSNYQASLNHLDTSFRNGDGWWGNDRKPVKWFECAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XEQ8</accession>
    <name>A0A6G0XEQ8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_005547</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000071">
        <property type="protein sequence ID" value="KAF0738619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XEQ8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015709"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.10.10:FF:000007">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="9">
        <location>
            <begin position="271"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="10">
        <location>
            <begin position="853"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="141"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1057"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="142"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0738619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1079" mass="122224" checksum="4F01E1F6FB776FAA" modified="2020-08-12" version="1">MSDTITDCIIGVNFLRRIRATINLETNQLLIPGSSGPISLSPLPSPPETPPRPPSISPVKRIKVAARSCCMIQCSLQDTIPRHSTILIEPIASSPVQVARSLNQPQDAVTWVQIRNAGDSPLICSPGEPIGTFTILPPDFEELGHPDENHATDTDTHATPASEELPPDDPLSPSLSQHVYPNYIAAVLSTPVLNELPINWEGSTLNPTQREMLRKILLQHDIFVTTSKAPGRTDLVKCYINTGSAHPIKQAPYRVSQREGEIMEAEIQQYLELGLIRPSTSPWASPVLMIRKPDGSIRFCIDYRRLNEVTIKDSYPLPRIEDLLDVLGKAKYFSTMDVESGYWNVRMEEDSIPKTAFTCKFGLYEWLVMPFGLCNAVPQFERLMEHVLRDQIWRSCLVYLDDVIVYSDNFTSHLARVNDVLCCFARAGFKLKMSKCHWGKSSVAFLGHIVTPAGILPNPEKVKSVLKIRELRNVAEVRAFLGLAGYFRRFIKGFAAIANPLEQLKTSPSFHWTEECKRWLDTLKQKLVSPPILAYPDFEQPFIIYVDACPIAVGAVLMQKQDKHERVIAYASQVLDATQRRWINKKDGTSEIECFGLVWATTKFRPYIDKRHFTIYTDHAALVWLFKVGSKSGNSKLARWIIQLQALDFTVIHRPGTAMGCADGLSRLPISAITRSVAARQQTVIPDLAEATPDPELPPYNDDSYELPTSPLASAQGDDPFIIAMNAYIQDSALPADPSLLTLVTRTHDQYALQGTLLCRRVILKTPIRNPELHLVPVIPLGWTRRVLQLCHDSPLAGHFGVARTLDRVRRVAYWHGWRSDVHEYCRVCVRCGAAKGSRPWRQGRLQRMPIYLLRGPFNFLVVDALGPFPITPRENRYVLIFIDYFTRWPEAFAVPDLKTSTFTRVLIDEVLCRYGVPERLLSDRGTNFVSELAHSMYKVLGIDKLSSAAGHPQSQGLVERFNSTLATMLKMYVNSVQTDWDLYLPRLLWAYRTAYHETLGDTPYFCLFGRDPISLLHLTFLNQDPPWRSNDLPQWRRQQSSWFLATRRLVESQLIKGQNRDQRTSRQRPIEFQPANSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XGC9</accession>
    <name>A0A6G0XGC9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_005099</name>
        <name evidence="3" type="ORF">Ae201684_005100</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000066">
        <property type="protein sequence ID" value="KAF0739173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VJMJ01000066">
        <property type="protein sequence ID" value="KAF0739174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XGC9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015319"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036174213" evidence="1">
        <location>
            <begin position="23"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0739173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0739174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="158" mass="16978" checksum="DDDDBBD6CC6BD0FB" modified="2020-08-12" version="1">MMLKLQGLVLVLVALLQASREGQRVESMPMAQLDSGLDENPSGRVALRGLKAEGLKNDAVMFFKKSKNKQNAAAIVCAEIAKFANGQRAHCASATKSSCSVPGYVFLTNTYGNDARQFKDVAYVNQCGTCADVIDAIRYGCQASAKTDRKAAKTKPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XI77</accession>
    <name>A0A6G0XI77_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphoribosylaminoimidazolesuccinocarboxamide synthase</fullName>
            <ecNumber evidence="3">6.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">SAICAR synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_004486</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAICAR synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.6" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000055">
        <property type="protein sequence ID" value="KAF0740045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XI77"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007019"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01414">
        <property type="entry name" value="SAICAR_synt_Sc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000015">
        <property type="entry name" value="Phosphoribosylaminoimidazole-succinocarboxamide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00137">
        <property type="entry name" value="SAICAR_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018236">
        <property type="entry name" value="SAICAR_synthetase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009251">
        <property type="entry name" value="PRK12607.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43700">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43700:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01057">
        <property type="entry name" value="SAICAR_SYNTHETASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01058">
        <property type="entry name" value="SAICAR_SYNTHETASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAICAR synthetase/ADE2 N-terminal" evidence="9">
        <location>
            <begin position="40"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0740045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="332" mass="37594" checksum="5245F5F1A3320509" modified="2020-08-12" version="1">MSAIVREAEDRTKGYLPQITATPALSATELFLPAPVTKHVGKVRDVYVLPERKQVVLVSTDRQSAFDRQLTSVPAKGQVLTLTSTWWFNATRHIVPNHMIANPHPAVVICKQAKVFPVEFVVRGYITGSTSTSMWTNYAKGCRDFCGHKLQDGYKQHQKLPENLVTPTTKDDVHDELISGAEVVSSGRMTQEQWDYCHAKSLELFAFGQETAATRGLILVDTKYEFGVDESGQILLIDEIHTPDSSRYWLAASYEERMAAGLSPENIDKEFLRLWFRDHCDPYNDAVLPEAPKDLVHELSRRYILLYELITGNRFEFQSPSLQAAVDPFFQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XIT8</accession>
    <name>A0A6G0XIT8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_004465</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000055">
        <property type="protein sequence ID" value="KAF0740021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013081"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019092"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000904">
        <property type="entry name" value="ABC transporter A family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000298">
        <property type="entry name" value="ATP-binding cassette sub-family A member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF36">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="502"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="534"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="605"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1181"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1226"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1257"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1297"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1333"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="690"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1401"/>
            <end position="1634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1008"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1010"/>
            <end position="1029"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0740021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1816" mass="199664" checksum="79EEBC73407925D4" modified="2020-08-12" version="1">MIQHSTSTPVAEACTAVPHKRRGFTSTLLWKNFLMKRKHPIKWAFEVLIPVALIVLLGGLKTLSDDVAVPEGWSTDDVAHEHDKNGTSYSLFAQETSFGNVTSLRYYQTEATVSGLLLDMATTSWTTRKRASSMTTDENTACSAAAFAGNVSADVNSPYAWPSTCRPLIIPRKLAIIPDNDFTRRYFLQTLSVWYPRVPLDASQSLVIPAITDSVAFFADEASLEAYITGGGYGKNFSTPTIAAAIVFTNVPPTLGSVGNVEYKLRLNSSLDDGGSIGDIPRTNAKAYQPLQRSIQTSEYMHYAKTGFMAYQTLVTRFALCVPDWNTQNKTTTANCTKPTSVMTSSTTSDLAFVAQVQNDPNLVASIAIYMQTTKNSFNLTAVPPTSLSSLAKPLRQMPQPVGGAAVFPMPIETYPSSPFFDSVSDSLGIIFLLSYLHILSSVLVALISEKESKARELMKILGVRDSAIIVSWYITYGIIFVVAAVLQAIASKVMLFKHASLAILFVFFLLFGWTVMSYGYMISAIFSKSRTGTYLGMIGFFAMYLGTVAFTDTSTAESKCSVCILSPAAMTFGIKSLEQAEGNGVGITTSNWTADINNFKFTTALYALMIDCVLYTLLGLYLERVVPKDYGVTEKWFFPLSVSFWRKKFIQRRCRGVQNDMAVAVDINQDNFEPVGAELKRQEVTGEAFQIHNLRRVFPIPGGEKVAVKNVNMTMYKNQITCLLGHNGAGKTTLISMLTGMIPVSSGDATIDGLSLNDDRAEIRESLGMCPQHDVLYAELTVEEHLLFYGKIKGYRGDVLETEVEQKIVEVGLTEKRHVYSSELSGGMKRKLSLAIALLGDSKIVFLDEPTSGMDPYSRRSSWEIILNNRMNRIVVLTTHFMDEADILGDRIAIMAEGELRCCGSSLFLKNRYGAGYNFALVKAEHCNTPALIQFVQRHVGDDTKVLSNVGTEISFQLPMDGSHLFAKMFAELDDKLDGLGVVSYGISVTTLEEVFIKVAEIGDENHQHTLQKTDPSTKSAPSSSVDGSRSGFRLTDNAPLSSLKMFAVHFRALLLKRIRTARRDKRMETSPVLGQYGGYVLLGSSQDRTFGYNLAVNTTAIHSAIVYKAMMDEALYRTIASDKDVKLTCTNAPLPLTDSNKLYLTTVVLHRALLGEREASKPQLQASATRVWCESATFWLANFAFDLILYAVPCIFGLLAIYFFNITPFTGHDCTSCPSTPFAALVVVFVLFGLAIVPFCYILSYLFVDAPSSQTYVYLINMVLGTILIVVSSVLDSIDSTKDVNTHLKFLWRLSPLFCIGNSLNALSTSTLNMALGLIEKDTSAFSTKVVGWEIAYLVIEAIVFPLVAIGIDYGLSFPKIKAIVTKDPHVVDAPFQVDEDVQAEEQRVAQGKADADAVVMKNLRKVYKGGKVGLVDLSLALPKGECFGYLGINGAGKTTTMKIMTGDVLPTSGAATLGGFDIMTQQLDVRRLIGYCPQFDALIDLLTMREHLELFAAIKGVPIDLIGATVMEKMDQMNLNDFENKLAGTLSGGNKRKLSVAIALIGSPPIIFLDEPSTGMDPVSRRFMWDVIADISTRSKESTILLTTHSMEECEALCTRVGIMVGGRLRCLGSIQHLKNRFGDGLMMHVRVAPVSSNDVDRFSNEAFGLDTMLTKERMDEACAALGKPHRARCVTSSHATGYVLAESLTRNGYIRVHDFSAWWLSEDRFEALSEYLGQGFGSANVQLLERQSDVSRFKLLGTKQTLALSNVFSMIETSKADLSVKEYTVSQTTHEQIFNNFASQQTQETGVARGVETQRKKNAHDNYQAMSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJ85</accession>
    <name>A0A6G0XJ85_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_004408</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000054">
        <property type="protein sequence ID" value="KAF0740175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJ85"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017106"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15841">
        <property type="entry name" value="SNARE_Qc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="3">
        <location>
            <begin position="30"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0740175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="122" mass="13467" checksum="688FD7B6C6F10670" modified="2020-08-12" version="1">MERGSQPRIKPGASYEAAETPRHVALTIQEQQRQQHEDALDDILAGAQHSRNVASGIHTEVQSQNNMIDDIGRNVTRATLEVEREANKAAAINKQRAKLCTLYVAIALLVTCLIVLSQVKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJ89</accession>
    <name>A0A6G0XJ89_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="7">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_004160</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="7"/>
    <dbReference type="EMBL" id="VJMJ01000052">
        <property type="protein sequence ID" value="KAF0740425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJ89"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015910"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000119">
        <property type="entry name" value="Ubiquitin specific peptidase 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF758">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="77"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="25"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="398"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="429"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0740425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="599" mass="67190" checksum="CAD0F1D2765ACB1C" modified="2020-08-12" version="1">MMLATGTTVQLKTVMQLVKERRIDFRRAQRPENAGTTPVKGSVKTANASKTTAASSSSLTDEIRALVLWTQPRKIGPGLMNLGNTCYLNSVLQCLAYSPAFAQYLVSRPASATSKTQQGFHAERSMTRLLAQMHSPTTPRVIQPREIVMSLKQIAKGFRIGRQEDSHEFFRHLMEAMHKSTAKQKTNDTSTLVHAVFGGTLRSHVRCPKCKFISERIEPFLDLSLEVSSGISSVPAALGHFTAVETLDAENAWKCGGCSQRTRASKGLNVHDVPNALVLHLKRFDGFYGKLKKHIEFAETLNLNQGKILTKPIADASYSLTAVLVHAGASPDCGHYYAFVKSPAGTWHEMNDETVRVVNINTVLQQRAYMLFYTRKTAKPFKPVVAPKAEVKAPLPVQQEVRKPVPPIPANIDQGETSQESFSDEGSEESQKFVDPEPVEKETPKVVKAWTFGPTFTGSLHRYRRFRTAWKRYETTSVVVPTKTKKPTAAATPAPLVVKKAGFVPHRKFQNSLLSADVPQWRDEDEDVSAELQKEHNQKVRQLNSELWQAKRCKQLDYWDQTLDQGKVKKVKKRKEFVANEGRMNQFQRALDAKKAKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJG5</accession>
    <name>A0A6G0XJG5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Adenylate kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_004142</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the adenylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000052">
        <property type="protein sequence ID" value="KAF0740406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJG5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005182"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036193">
        <property type="entry name" value="ADK_active_lid_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57774">
        <property type="entry name" value="Microbial and mitochondrial ADK, insert 'zinc finger' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0740406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="399" mass="44921" checksum="CF7E7ACE6D32C9FC" modified="2020-08-12" version="1">MIHAYVSGPPGSGKTTLCKKVCAALKLEQLSTGEILREHIKQRTELGKIAKKCIASKSLVPDDVVIEMLVERMAKANERGWILDGFPRTTEQAVALRMKNITPTVVLILELPTSEIRGRLVGRRFDNKTGDIYHIEFNMPRDPEVAVRLIHRDDDTAEKVPPRIEAYSSYNQPMHREFLSVAYDIDADRPIPDVVTEAIEILRSSKKGPSNQVKEVVKKSLVIEPQPEETEFSPPKSRPVSSIKIEKAPQKIENEIQRLTTDLQDNNIAPKRAPSMEVTKLVDMERFKTMLVSGFDVIKHGRRGAPHTRTLFCDVEFKRLFWQKPDKKELKAKLDQSIALADVIQVVQGMKTDVFKRSGDSSKSDRYLSLIADDRTLDIEVASEELCTLLVNGLTALAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJJ5</accession>
    <name>A0A6G0XJJ5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_004171</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000052">
        <property type="protein sequence ID" value="KAF0740436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJJ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016923"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0740436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="327" mass="36884" checksum="80ADC3233314CDF0" modified="2020-08-12" version="1">MDTTPTSGTSVVVRRSPRLQLPFDDTAPSRQHAAVYAFVVDFRVKETVQQRLSTAKMFGEHHISGDTEDAIMQALWTLVSPRVENLATANENTWTVASERPGIEHFDFYVTFKFKTKCLSLREVMSWSVRNRGGTVALTAFKYGNQVGNQQHLAELKAACIDPEIQDRAGAATHEIQKNIVEQLKSRWGRLFRGHEMAWLMWAARIAKKAVYLRSVEVTQPPPAELARWFTPVGASAEEHVDALRRNVQLASEVVDGLIAHVIRVRDTQLAQFELLRNGFDGMMEMLETKKRIIDAYSADLLPLRDNEALLEELAHIPNVPDDCHAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XKT1</accession>
    <name>A0A6G0XKT1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Ae201684_003829</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000042">
        <property type="protein sequence ID" value="KAF0740945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XKT1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016198"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01479">
        <property type="entry name" value="Sec24-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041742">
        <property type="entry name" value="Sec24-like_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF39">
        <property type="entry name" value="SECRETORY 24AB, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="14">
        <location>
            <begin position="372"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="15">
        <location>
            <begin position="446"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="17">
        <location>
            <begin position="687"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="16">
        <location>
            <begin position="782"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="13">
        <location>
            <begin position="920"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="55"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="218"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="270"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="295"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF0740945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1053" mass="112003" checksum="C90AD02F638AB4DA" modified="2020-08-12" version="1">MNHQFNQQPPGSQGGGGFRPFNPAQGQQPQQPQGGPPGSGGFPPHNQPPSGGFNPAAQPGGFQPAPRSFGAAPSAQQFAPQGPQSQPGQFGAPRGPPQVGGGIPPQQSGQFGAPRGPPQVGGGQPPLSAPNQFGAPRGPPAVGGPIPQGPPSQSGQFGGPPRGPPQVGGPPAPGAAGLTQQFGRMNVGGPPGAPSGPPAGPPLARGPPMGPPVGNQGPPAPGAPQFQHPPPGAGGFQQGPPPGPGGFQPPPGPAGLQQGPPPGYYQQGPPGQPGPQGYPPQQAPPGGVPSGDFNQAGFAPAGPAQPSGQLSEAVLAAQCDPRYMRLTVNALPHSQEQANKSSLPLGVIVQPLAKPDKGKELDVVNFGASGVIRCKSCRTYINPFVQWVDNGRRWRCNLCGVSNDVAGNYFCHLGPDGLRQDKDERPELRGGSVEIVATAEYMMRPPPPPVFVFVIDVSAQAVASGMVAVAADTIKRELDNLPGAPRTRVGFITFDSAVHFYNLKAGLNSPQMMVVPDINELFIPIPDELLVNLSDSRDVVESLLDMLPRIHQNTRNPDTCLGPAIRAAFRLMTSVGGKMLVFQSSLPTVGQGALKHREDTRLFGTAKEHDLLNPVDTFYRKNAIEFCRQQVSVDTFLFSPQYTDYASIGSMSKFSAGEVFHYPGFNAAKDGEKFSTELAHCLTRENGWEAVLKIRCTKGMRLVNFYGNSFLRGPDLLALPNVHEDASFAIEIEHQDALLTASVICIQAALLYTTSSGERRIRVHTVAIPVTKLFAEVFRSVDVDAMCNLIAKNALEVALKTGLDAARNKLQTVCVDIARAYRTSGAYGQNPNAGYQLQLPESLQLLPLYIMSLMKSPAFRGGTDIGSDERSHVQYTLYNMSVPHSRCFIYPRLFSLLDLPAEAGLPSDNPQAVTAGNDKIVLPPVLNLSVERLNTEGAFLLEDTINLYLWVGRSLNPRFVSSLFGVDSIEGVDCRELQLAPPKDDIGTRVHNIVNALRDDRTTYMKLHVIREGQPVEGKFFWKLVEDRASFAGGQASYAEYLGQINRLSHGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XLA5</accession>
    <name>A0A6G0XLA5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_003578</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000041">
        <property type="protein sequence ID" value="KAF0741006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XLA5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018529"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026894">
        <property type="entry name" value="DnaJ_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052423">
        <property type="entry name" value="EMIR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44094">
        <property type="entry name" value="DNAJ HEAT SHOCK N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44094:SF8">
        <property type="entry name" value="DNAJ HEAT SHOCK N-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14308">
        <property type="entry name" value="DnaJ-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="180"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0741006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="561" mass="61015" checksum="DC3976251223EB85" modified="2020-08-12" version="1">MQADTDADNNRPAPPPPAPIKPPAAPLQLTSGQPEDAMDKIEMPQIFSTRAPRDAAAGLSSGLKNMGKGVAAGLGSLVAMPILGAREQGVVGFAKGLAAGTVSAVVMVGGGAVTGVTQIARGIAATPRAIISSNENKIWDQDKQQWYLYNLKGEAAEVLAAEEAEAAAASAEKKDVKETELYDLLGVEPNATEAEIKKAYRRLAIKLHPDKNLNDPSASEKFQQLGAAYQILSDPQSRANYDEHGKDGVDEQLFMDNSQIYDMIFGSQAFENFVGELNLMTLQQELGKMSSDDSDPTHLFTQTNYVKIKQRKREVHCAVYLATLLESYATDTSENHINFRTSISTTAKELASSAFGGTLIGVVGYVYEEQAHRHLGFRKSVTAGLGLQNVTRSAHVLSTKYRFMTSAYSAFSKYNKAAKKVEEFEKKMAKEEQLKGEEKKKGVEEDGSKQEEQSEGSKEEKVPTPEMDDLSRQLQQETLGSILETAWNFTVMDVEATLRSVCFKLFKDSSVTAEARIKRAEGLAIIGEIFLASSQTSEAGLKEVMEKLNLANPESSSTSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XLE0</accession>
    <name>A0A6G0XLE0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_003539</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000038">
        <property type="protein sequence ID" value="KAF0741250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XLE0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015719"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005221">
        <property type="term" value="F:intracellularly cyclic nucleotide-activated monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050866">
        <property type="entry name" value="CNG_cation_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638:SF11">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0407">Ion channel</keyword>
    <keyword evidence="1" id="KW-0406">Ion transport</keyword>
    <keyword evidence="1" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="3">
        <location>
            <begin position="39"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0741250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="413" mass="45669" checksum="A63BEBE1F528DB02" modified="2020-08-12" version="1">MWEHSEGVVESQALAPLSSALREDIAVYVKRDLITKVHLFSECDQDFTRAIVSVLQAEFFVAKDVIIREGDYERSMYFIHSGFVLVTNIAKTYEVVKQKGDYFGEMSLLYNTPRSGSCSAISNCDMYILDHNSYEYVLERFPHYRERNLRTWCTGAPPTSTSSPPRSNEVPPADGSNVDVLHLQSMSDHESAPVLTPPTEEGDALMRRTSQMQITKAVVAFAARTHNIRESIAHAPLQRQSSKKLEPSHGVRRQSSAIANKLVSRGSYNRILDTTAAEAIPSAAPTAPAIVVNPVEANFIEPLSDPPARKILARGILPHVATTPEMDLRRRKISAVWEDVKASPRYMERLHSIEAMEATEAMDRPKTASSAVSTTAATAAKQTASLVVRQRALNHAAPGSGRRNSVETLTIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XN53</accession>
    <name>A0A6G0XN53_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Protein farnesyltransferase subunit beta</fullName>
            <shortName evidence="9">FTase-beta</shortName>
            <ecNumber evidence="2 9">2.5.1.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_003019</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-cysteinyl-[protein] + (2E,6E)-farnesyl diphosphate = S-(2E,6E)-farnesyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11535"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:86019"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.58" evidence="2 9"/>
    <dbReference type="EMBL" id="VJMJ01000034">
        <property type="protein sequence ID" value="KAF0741827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XN53"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000858"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005965">
        <property type="term" value="C:protein farnesyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004660">
        <property type="term" value="F:protein farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097354">
        <property type="term" value="P:prenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02893">
        <property type="entry name" value="FTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026872">
        <property type="entry name" value="FTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF6">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="10">
        <location>
            <begin position="59"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0741827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="395" mass="43800" checksum="DF93EBD692E69457" modified="2020-08-12" version="1">MATTRSLPTDDWPTATTRLQRETESSCTAFFVPMDSLPKSELHKLQMAGFISQDNQVRLLRDKHIPYLIRGLEYLPPGYASMDASRPWFMYWILHSLELLDDEEDIQKFADSCMNTIKRCWSGSFGGGFGGGIIQLGHMATTYASCLALAIIGTPEAYDLVDRKGLNDFFLSLKDPATGAFHAHDQGYVLYFTKDLIYTLYGILTPELTAGVVDFVRACQTYEGGFGPFPHQEAHGGYCFCAAAILDILNAWDAVDVDALLHYTAHRQMAVEGGYQGRTNKLVDGCYSFWQGSVPALLAKANKSGGSYVSDAEAHQRYILLCGQQIEGGLRDKPGKPRDHYHSCYVLSGLSLSQWNGNTLVGDNQNLLIETHPAYNIALDKVGRIQAYFAAKDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XN58</accession>
    <name>A0A6G0XN58_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_003018</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000034">
        <property type="protein sequence ID" value="KAF0741826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XN58"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000859"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0741826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="145" mass="16798" checksum="A3246C920DBDF85D" modified="2020-08-12" version="1">MNCIEVAIRTAAELLNLPFSYTQEEYMDFLKKTSFTPQAGLEKKDVKILVDRFMTKGFKIDRDIYNEGYLAEFHGPGVYTMQTEETSKMGHFWTVHSELGAVLVKSEDPPRGVKAYEELYQQVDSIRKFVPRLPNSKKRKHSNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XNC6</accession>
    <name>A0A6G0XNC6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_003005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000034">
        <property type="protein sequence ID" value="KAF0741813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XNC6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012480"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012481"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052050">
        <property type="entry name" value="SecEffector_AnkRepeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586:SF3">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0741813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="721" mass="82894" checksum="65381D1C7CD5E456" modified="2020-08-12" version="1">MEQAMMEESSPSIIVRRHRRDDKQSQRMAQYREQKKQEFLVLEQSISKLERIRTELLQRAPKPKQKSLLLPWKEVAKALRDLRSLGESQNKDLRSQLQRHQKLVEEMVHWVSLHYSIEKPPSSGRRTWRHVSLLADLTSRKLGKEWITQQMFHNTDRVFQEYGFPSIDATAHLLQDFHFLFSEDQGYRFITRHFTIMNKPMDAFVEHYRNTLLPFQCCILGYDSDTTPMLVNDTEGNIQQLALVTPRGEHVNLLTGDFRTPDRIVFLGRQIQDDELHRHENRRQRDRMFWCDLHRMPDGTCRGRGLWIQSQAFRLDGVVPLEEDGFDYDIDYSNCPDHLKEVRLPNLFVDAVKRNWASMLAKQGKRENWSQSKSKPVEKTTSALITMAAILDNVLRSTDLLGAIFEYQNGLHQDMLPFRSVVPTLCTDGQYSIQESDFEALHALLAPWYKTHGIARLTKLWNAIPAIQECVVVHAALYGHVEVLRFLHERNMLSGSQWSTQMAMDIAARSGHIDVLEFLHTHRKEGCTVKAMNWAARYNHLHVVQWLHFHTTQGATALAMDYAAENGHLEMVQWLHAHRTEGCTTGAMDNAAANGHLHVVQWLHAHRTEGCTEDAMDGAAAEGHLNVVKWLHFNRSEGCTEDAMDEAAENGHLDVVQFLHTHRSEGCSEAAMNDAAAAGHLEIVKYLLEHRDEGEVDEALSCAKAARQVNVVAWLRQQLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XNI1</accession>
    <name>A0A6G0XNI1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_002937</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SUN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000032">
        <property type="protein sequence ID" value="KAF0741999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XNI1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014021"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005556">
        <property type="entry name" value="SUN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03856">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="512"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="65"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="538"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0741999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="584" mass="61317" checksum="D5164702D8BC1F28" modified="2020-08-12" version="1">MQDRVAAVLWTDRRKRLLLAAFLTLLALFAVVATLIATVESHNDANVPPPGDATARENSVAGHEMIAPPISPTSAPPASLGGEVSSSPSSSSSGGADKDDKNATTRAPTTTAAPNIVTQCSAADPTSVCYLPPASSSYCMLDKSMDPNVMYVANPSIANANGGFAMDQACASGSRCTYGCEPPFVPSSNGWSNADCIPYLALCPPYSPATATGGILCDNGRVIADDPTQHLCVPGLNTSFVTNYVPATLSTCLAVTPGSGSPMVGVEIAQNQTKQLTSYPQWFWRGVSAQMYVNLPGVRRIAACQRNADPLSLNAQGLDTMPFVVGGGSLPGSGCAACGQHTLAFNDGFDFRKAYSKVPGYGIRVRNCNDQSCGPVQCDATYVYNPTTLTLDAYWVKYNTVFDSTSVGCVADVVTGYGWTPADGVSKFTLYEYYPTTASGQQTASCPGCSAPSAFDPGYCKKLRQAAPARFGSGVVPAQFICTAVGAAVGRAATLSTFSSNDGGNDATTTTIYIEAGIASFLLLVVIGLVWRARKLKPQTSSRVEEPTDSMDMTPDRRQSMHPKATYVPRSSTTFDAEDVIVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XQ74</accession>
    <name>A0A6G0XQ74_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_002598</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000027">
        <property type="protein sequence ID" value="KAF0742505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XQ74"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012305"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24296">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0742505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="543" mass="61108" checksum="4E48EE7775FE8698" modified="2020-08-12" version="1">MQFCLVAPSQSICNPRRLYLTNATVGRHQAGSLSIKPLVAALSVCLLVAAGGHILLQLFSVLKRKWRIAVSIRHLPGPPSLPIIGNLHQLGMSLPRIHWWKLEMAEQYGGTYATRVDCLMDGSIVTNKPENIEYVLQTNSDNYIKPKMMQETCAEVMGQAIFAINPDSPLWTLQRKLMSSMFSVNSFRKYMKSVFAEHTAKCIATLHAVSQKNDTIDMELVLLTLTTDISFHMGFGRHVPAEMNSRHFHNLFRDASTITASRFTKPWYKWFGWCMPSEMQLKAVMAEIDGMFYRIIHTRKMEGASGSSDILSQLVARQKAGEPITDTFLRDMMMTVMLAGRETVASSLLWIIHLISQHPDVEAKVFAEVQGVDAMNYDAVAQLQYLEAVMKETWRLFPPTALELKCAVHDDVLPDGTFVPAGVNVEYSPFVMGRDKTRWTDADKFIPERWLDPSFSPPTDYEYPVFNAGKRKCVGQRIALLQVKYILCSLFQQFRFESAKSDKPRLTLGIALFAHGGLPIVPIARTKTHAMRKPTPPCATSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XQH9</accession>
    <name>A0A6G0XQH9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferroxidase</fullName>
            <ecNumber evidence="3">1.16.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_002320</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the frataxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.1" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000024">
        <property type="protein sequence ID" value="KAF0742777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XQH9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006466"/>
    <dbReference type="OrthoDB" id="1897642at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034986">
        <property type="term" value="F:iron chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.10">
        <property type="entry name" value="Frataxin/CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017789">
        <property type="entry name" value="Frataxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002908">
        <property type="entry name" value="Frataxin/CyaY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036524">
        <property type="entry name" value="Frataxin/CyaY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020895">
        <property type="entry name" value="Frataxin_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03421">
        <property type="entry name" value="FeS_CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03422">
        <property type="entry name" value="mito_frataxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821">
        <property type="entry name" value="FRATAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821:SF2">
        <property type="entry name" value="FRATAXIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01491">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01219">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55387">
        <property type="entry name" value="Frataxin/Nqo15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01344">
        <property type="entry name" value="FRATAXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50810">
        <property type="entry name" value="FRATAXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0409">Iron storage</keyword>
    <keyword evidence="6" id="KW-0410">Iron transport</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0742777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="178" mass="19734" checksum="4B4B486B2123CCC4" modified="2020-08-12" version="1">MPLSIRMAGVNGIRAVGRLVARRLACARPQVRAFQALATPRAGEWPRSKSFQRMLFSTEGTNEVVSALSESEFTRYSDATLNAILELMDGIEAILPDADITLSQGVLTINLGEDGTWVLNKQGPNRQIWWSSPISGPKRFEYDIQSGKWLNTRDSSIELVELLSLEIEELTGIIVVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XQU6</accession>
    <name>A0A6G0XQU6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_002310</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000023">
        <property type="protein sequence ID" value="KAF0742916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XQU6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019840"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026274986" description="PPM-type phosphatase domain-containing protein" evidence="7">
        <location>
            <begin position="25"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="8">
        <location>
            <begin position="109"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="49"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0742916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="371" mass="40972" checksum="A51A6CFF34F6F959" modified="2020-08-12" version="1">MVQGRWKHTSALAWRCGLAMSALSASNGYFHAALEADPDVQAMRERIAARNKASQDRAAQARQYRQQQTPATFSEPQEPSKSKSRWNNRSWTDKADVLDGKTLSNLNLAVSSSTKVGKRTYMEDRITMVTFDSPITEEPLAFVAVYDGHGGTQCASFLQTSLHGHLKQYLANMETSFDEASHRDLREVLTKACLQTDQAFLNSHATDDSGSCAVFALIGNDKWVVGNVGDSQVVVSRNGRAIDLCVAHSPQNPDERARILSAKGHIVQDRYIFGYLGVSRSFGDRFLKLDRPVVITNPDVVSSHRRPGDEFLLLACDGLFEVFSPQEAVDFVAHHKTINQMAPQAICDLLVQTAIENGSQDNVSVVLVMLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XRR3</accession>
    <name>A0A6G0XRR3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_002185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000022">
        <property type="protein sequence ID" value="KAF0743129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XRR3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015828"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14690">
        <property type="entry name" value="bZIP_CREB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="166"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0743129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="427" mass="47617" checksum="027CC45654DBEDD4" modified="2020-08-12" version="1">MDLGEVGPGGASTFDGPGSVGAGAESGYSNVAPNGLESTDMFRDEDAFQWLFLTSDLAPLDQAVVLEDEMKEDDLFPLAQDATATPSLVPAQPPTLSGEQHSLDLSAAVVATASSIAPPKPPMIKRESTVSSSRDSVASFDDSDSDDSQSDESDRSSLTASTTDASKKKRKRLKRNRDSARESRKRRLARIQENELRLKKLEIENTDLKMRLKIGKEAILVERQEKATYKQKMQHLLQTGASEAEVAKFIEQYKTNYSDYGAKRQETISFHIARVRELLLPTQVTKMCLYSVENGDEVPMKPSMATQHAPPPPSDSESSNLWEILAKELNISQAQQRQIFQRREQIKVLRENLNKNLRNLAAFEVATQEKNRSLNNEVAMLQTILTPQQATKFIIWVKENPAFMYMLDQLVQSIIAGTDDVEKQVTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XSM1</accession>
    <name>A0A6G0XSM1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_001754</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000013">
        <property type="protein sequence ID" value="KAF0743612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XSM1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019343"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF408">
        <property type="entry name" value="OS09G0560450 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="103"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="276"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="333"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="388"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="461"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="886"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="956"/>
            <end position="1005"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0743612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1005" mass="110104" checksum="B12F3F1B2649FD02" modified="2020-08-12" version="1">MGGKLSQVYYREKDTALVRDFELLVQSWGKAEILHVSTQLRQVSFNFCLTLANFEEILELQHNSLFRPMIQRWFNLLKNTATSSVINGLEFIAALAVTGHTGKLIERISFIFDLFDFDNTGCLTKDELMILLKSTLRGLSKATVGLGFQLAKLCPMAQIEYLAAVCFRHCGLDATDDLRKDAFIQWVVATPKLTSILKCYVPKDRLSPDEAAAAIQRVARGMLGRNFVDELRLHKRLLQDQELDIAASKIQEAMIHRKKRQETVRRSKLERNAAHGAVYTFGANAHGLLGHEFQDLDKPIKEPKRSVYFQNSDQRVVGIAVGIVHAGAVTAAGVAYTWGGCLPGAFGTVEKGGELVRQCPKRVDDLTDVPISSMALGARHTMALSSDGHVYSWGSGEFGQLGHGDFTMATDIFQRQFDQHTSRSYPVVDLPLRLDKSLFGDVKIREIACGYYFSVAVADDGCVFTWGEGSDGQLGLGLTDDFCVGFLDDYLLHSSFTYMHTPQYVHVEEPIGHIAVGGNHVFAVSRNHRSVYEWGASFRRDGDAVYTPTRNVPLSNLYVKRIAAGKDYALAITGCVYLKLSGLETMYGVTAKFGCQPVDLYAGVSAPLIAAGVPKDKQAYAVKEEWTQKVVYVDRGKPTGVWLTIQGDDPFTLACLPSAFGPEFSRQVAFTGECFYTPQKLVSLKHYVRPEQVEGKLVVFHVEESDLPVHDADDDVPVVVERLIVAMVDKVRDAQECGALGVIIVFEFMADAFSLTTDSSFEFTIPSVMLNAAAGARLLSYITDKKRSGVPIKLSVYHHEDTLGDQLLAIQKSGATAIVVGQNDISKSPTRLGDTVFEGLGNRTGIANQMRIPVVMVSNETGSTIKAHYQRLIQDAFAEVGIASFGDVYAWGAGDHGVLGLGDMDNESIFTAGYDPATNTTYPVVKAPELIESLVQTRVVAISCGDHHAAAVSDTGDLFTWGSGVHGKLGHNSDQDEVIPRLVSALHAVNVIDVACGPQCTVRFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XSP0</accession>
    <name>A0A6G0XSP0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_001773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000013">
        <property type="protein sequence ID" value="KAF0743632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XSP0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006004"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0743632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="623" mass="69461" checksum="02724500BAEB9516" modified="2020-08-12" version="1">MVGLNLFRTSRTSELAPSENQKEPLASSTAFDKKRLDPAHDENLRPSQSTQPQSKRQKTTSSTSTATLMSAFSTGFMKKMVFGRSKSLGERTDEENSEERMSEYLGPRRYPEGTYVATKYGTAIVLQFRDEDDMYVVRMVYNAVAYFHADSIVREIKCMVGDRVKTKWGMATIEHYYVDEDKYSVALDWRWDDDHVWRMKASTKMFDIPTPANATLKSRAQAARSLMSKTFEEGVSSLRMSLPSTSAYTITSLIRLSSAPTPATTPAVVMPLKLSFTPVWSDLFGEGRMESIRKSDQIATIRFSKPHSCLAFMHVSSFRELEVGSGDAIATPFGDGHVVAYHRRGVYEIQLVYGATLYTASPLALIQAAAAAAASSKAKKATLTPSSSSSYFKMSGMSSLPKFNLPSLPQQRKEKYMVGDKLRCPFGVATIIRVQSNDQVFVCALETPATESSSATSSSAPPVLYVHAAQMDSMFPDGVLNTRLSMLVEKTKQAGKEWHSFSYSTASALKAQVKSSLDNAFKRWPRFSVDERVLCPKFGSGFIVAQRPDQVYVVRLRKLKILAYFHEEELRPFPYDKATHVIVGDKHVPVPMEVYQATNKKSRSAIIKESIAAQQHLAAMKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XTP6</accession>
    <name>A0A6G0XTP6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_001642</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0744005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XTP6"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0744005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="80" mass="9055" checksum="144E034B4CBDABF9" modified="2020-08-12" version="1">MRVEVTRQRKLHMGGDLDWIETSHEEIEGSCSLSLECVLSYCCCYLSLTCVALLRLPNLHCTMFPIVFHLGRLMAQPAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XTQ2</accession>
    <name>A0A6G0XTQ2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">COMM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_001403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XTQ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013072"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017920">
        <property type="entry name" value="COMM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07258">
        <property type="entry name" value="COMM_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51269">
        <property type="entry name" value="COMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COMM" evidence="1">
        <location>
            <begin position="92"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0743749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="159" mass="18062" checksum="1FA0798A479745CB" modified="2020-08-12" version="1">MHRRASTTIDRLEVTLHDTADAMGRGDSPRSEKWLRFYLEALSSSDDEFEVLLADYGIPNDMTDAVKEIIQARSPDIQRYLVRQAASISKVQILDFDYSVRLVMTSSNFHGEMYPTVLLKLMLSGGREATFELDQEELDAILTEFDEIEKAIKSIEGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XTU5</accession>
    <name>A0A6G0XTU5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_001469</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XTU5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002707"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051558">
        <property type="entry name" value="Metallophosphoesterase_PAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10161:SF62">
        <property type="entry name" value="CALCINEURIN-LIKE PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10161">
        <property type="entry name" value="TARTRATE-RESISTANT ACID PHOSPHATASE TYPE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="4">
        <location>
            <begin position="64"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0743823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="371" mass="41949" checksum="923F11DEC5F2F1E1" modified="2020-08-12" version="1">MRLSEWMCVVVLCGWCVYILSYFITSTNVDILRAADKKSKSKVLAAQLKDLPKLGTHHASLGFIVMGDFGTGSKLQAQVATSLGDFVQATKPSASFVISTGDQIYDHGLLSADDPAIISKFEMMYKHPSLQIPWYISIGNHDCEGNIEAMLGYSKRTTSLWRFPQRYYNMDHRIDNSTIVRFLVLDACDLVCGQEPEFKDYRCTPAMDAQTSITSRRLQYEWIEKVLSMSAPKSLNDPTELSRMWTVVIAHWGVYSYAGNGDTPELMSNLVPLLEKYNVHAYFNGHDHALEHVRKGSIQYFTSGAGGYKLHELKPQARSHPELIHVDMTNGFMWVEVSHDTFRVQFVDGSTTEVLYTTDVPYRSSNINKEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XUE6</accession>
    <name>A0A6G0XUE6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ae201684_000769</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XUE6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000711"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000009">
        <property type="entry name" value="Probable E3 ubiquitin-protein ligase HECTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF440">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NEDD-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="29"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="13">
        <location>
            <begin position="92"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="14">
        <location>
            <begin position="429"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="315"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="9">
        <location>
            <position position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF0744280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="779" mass="88790" checksum="5746F0314EB627DA" modified="2020-08-12" version="1">MRHLHFGLGIPTGSSRDEDRGRKKRSMAVLFGITLSSTAAAIVYTLLGLALVLLIGAIIYYWNYAKRIERFLENDNRNNNMMRQDLVDTFMERGEKEWTCSICFHDNHPSKKECVMCGTPQIVVDTIDPNMPRPSGLRKSDFVEPGLHKSRSVVLDQQSRIRSFHVRRLKQMNLTARQKAAMRRHLWRRKKGPDGNMHWVRIDADPDDPTRESTVDMEMYGQGHDFVDMLSPISNTGSSVPEEGDPNETHIALAMRDLGYMHEEEDRSTTPFQPLRATALKQLEEAEERKSMYTGITAFPGAAFGKSKAQSSGNDNGGGGGFGWGPGQTNFPLTAISEEERRNNFTTLSTGYVRHTTADGATEFAPALGVVVGESRQPDCDDDLEEIAALTFQEKNKWFLDQVQKRWRRYEDGHIQFVVRRDHLIADSMEQMLKCPASRFWERLRIFFENEPGLDAGGLIREWYELLCDQLFSDEMGLFVPTKGSNLAYWINPKATQRPNFQQEFEFVGRLVGKALIEGFNMKMSLALPLIKHMLEVPISFSDLEFLDEELYRNCHWLKKNDKAELLSLDFTVQGLTSTEIIELVPGGANIDVTDANKGEYLDLLLKYHMFQSISAPLNAFLKGFYDIVPLFLISVFDYQEFDLLLSGIPDIDTNDWRMYSEIRWIKLETPSPAETAVVEAFWSVVAKFSPEERARLLQFATGTSRVPVQGFKALTSTDGRVRRFTIQMVQRGPPPTGLMPKGHTCFNRIDLPLYSNKEELAKYLTLVINMEITGFWLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XUU2</accession>
    <name>A0A6G0XUU2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Endo-1,3-beta-glucanase btgC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Laminarinase btgC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ae201684_000794</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation. Active on laminarin and lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XUU2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019498"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF17">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE BTGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026243911" description="glucan endo-1,3-beta-D-glucosidase" evidence="14">
        <location>
            <begin position="19"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF0744306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="351" mass="39880" checksum="34481658D93BC348" modified="2020-08-12" version="1">MKASQIVVLVALLLTTHALNVKLSGVNYNPRKGADWEPWDRKCKSTEEVELDLRAISLITDNIRLYSMNDCNQVELVIPVAKEVGLKVWLGMWIDSYNTSYPAELATLKRLINNGVIDNDVTGLHVGSEAIYRQDVTIAKAIEYFYEVKGITTAANLTFPITIADIGDVYAGHPELFQVVDVVSANSFPFWENKTIEECITYFYMRMGPIMGMARVNNKKIIISETGWATAGWAYKAGIATPENAALWMNDFHIFAMEFGWTYYYYIAFDTLWRYNVNSNISEPEVENYFGLFDENRMLKPAYANLNIHKRKEYYVPPLPTQPDVPTPTKSNWDVFQNIAAAIISALDGSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XV56</accession>
    <name>A0A6G0XV56_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_000858</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XV56"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016821"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47177">
        <property type="entry name" value="F18C1.6 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47177:SF3">
        <property type="entry name" value="F18C1.6 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="45"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS N-terminal" evidence="8">
        <location>
            <begin position="384"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="463"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="478"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0744372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="578" mass="64653" checksum="1FBDCE5C4F07715F" modified="2020-08-12" version="1">MATAVDVADEMIDLCQESDGEEVKEEHIDGETKGDQEGEDSEDMCCICLDNVELDTQGFLLKCVHTFHFDCILQWAKVTNLCPMCKTRFRTVVKRDGNGNVTLSEDVRDTKQTYSSGSSQEISANANLFNEYACSLCGNGDHEDMLLICDANNCDSACHTFCLGLADVPPSHWYCPGHVHLPPPSRRSALQTATTLASLRSSRRSRRSVRMPVRRITQLEARVGIRRGQRLPLPFENEVMRYESGNTAQPNRRGAREFQSAAARDLRCMQAEASRILQCVNGGQSRMTLISPEVRAATIPKRRIEEIQAIISSPPQSKRPAKKPASFRAEYDDLYHKMERAHVQDTSTLLPTASKLRLLPTVKRFFDGLNDAQKTQVLEWGWLRVLKQWLEPYGPAKLQHVQVMETVLTILDELPIEKEHLKESDGLGKVVTQLVRQLDMHSQAKATQLLTKWSAFVRASSVDSANEEEETKRPAPTPVAAPAVAFRAPPPPAKRSSTPTHSAQHMKPLIVQHIKQQLYPAYHLGKLSKDKFTQVTKGVCQLFLDQVAVMSSAALTREGELSEISKKRLNSLIDQATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XVH7</accession>
    <name>A0A6G0XVH7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Calcium-dependent protein kinase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">Ae201684_001131</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27 28">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Cilium</location>
            <location evidence="2">Flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Host cell membrane</location>
            <topology evidence="4">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="21">Parasitophorous vacuole membrane</location>
            <topology evidence="21">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XVH7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018514"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020002">
        <property type="term" value="C:host cell plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020005">
        <property type="term" value="C:symbiont-containing vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15898">
        <property type="entry name" value="EFh_PI-PLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000398">
        <property type="entry name" value="Calcium-dependent protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000880">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050205">
        <property type="entry name" value="CDPK_Ser/Thr_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24349">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 23" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18" id="KW-0966">Cell projection</keyword>
    <keyword evidence="16" id="KW-0969">Cilium</keyword>
    <keyword evidence="14" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6" id="KW-1032">Host cell membrane</keyword>
    <keyword evidence="15" id="KW-1043">Host membrane</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="19" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0519">Myristate</keyword>
    <keyword evidence="10 23" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-0564">Palmitate</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="25">
        <location>
            <begin position="92"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="26">
        <location>
            <begin position="390"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="26">
        <location>
            <begin position="426"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="26">
        <location>
            <begin position="492"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="24">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00024334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00060437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00068067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="KAF0744673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="556" mass="61331" checksum="1D5FEC6A57E50C56" modified="2020-08-12" version="1">MGNNHSSRGDAKPRRQRGAVPQPPSPPRQVSPPGTPPHAAGGSARAVTTPPAPAVAVKAPPPTVPVVAKPPAATVSKDNITGSLGDVFSVYNVEKKELGHGHYGTVRIGTHKKLGHKVAIKTIPKVKVSRPETLRREIEILRTVDHPNIIKLFDVFEDTRHLHLVTELCTGGELFDRIIARGHYTEADAAKLVRKILDAVKHCHDKDICHRDLKPENFLFATKDEDAELKVIDFGLSRTDSGDQSFMTTRVGTPYYIAPEVLGRHYDKSCDLWSIGVITYILLCGYPPFYGDSDPEIFASVRSGKYSYDTPEWVGVSAEAKDLIDHLLLLDASKRLTAAQALQHPWLSGSAPANERNISGTILGSLKRFQGHNKLKKVALAVIADQMTGNEINELKKQFQKIDIDGNGVITMQELAIAVREMGQDVLESEVFQLLQGIDIDGDGSLDYNEFLAATMKRNMFNKQEYLMQAFNYFDTKKQGVITKDDLIRFMGSEEHAQEIMDEIDTNGDGEISFEEFCVMMEQKGLGEELTPRGDHQNVGFNADAVAAPAIKTTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XVJ3</accession>
    <name>A0A6G0XVJ3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rho GDP-dissociation inhibitor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_000955</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rho GDI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XVJ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010425"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005094">
        <property type="term" value="F:Rho GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.50.30:FF:000004">
        <property type="entry name" value="Rho GDP-dissociation inhibitor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.30">
        <property type="entry name" value="Coagulation Factor XIII, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000406">
        <property type="entry name" value="Rho_GDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024792">
        <property type="entry name" value="RhoGDI_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980:SF3">
        <property type="entry name" value="LD16419P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980">
        <property type="entry name" value="RHO GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02115">
        <property type="entry name" value="Rho_GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0744479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="22755" checksum="7CD2E4A5FCE9BA42" modified="2020-08-12" version="1">MEKLEAGPAVPDVEYKISERAAASLNAILEKDKDDESLQRYKAKLLGAAAQGDIGDTKDRRSVVVQHFKVVFENNRQEITYCLDTQDGLDSIRNTPFEMEEGAKYKFAISFRVNRDIVSGLRFHNKVCKHLFTAHEEVVLGSYAPQSCSYEFVFPRHEWSEAPSGMLYRGRYHGECKFVDSDDKEHLRFQYSFDIKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XVR6</accession>
    <name>A0A6G0XVR6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_001235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XVR6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021818"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0744781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="294" mass="32552" checksum="7B03395C6B7736B4" modified="2020-08-12" version="1">MEVVLDDVKETVYKIIMIGSAGVGKTNLIGVGARGLSYNDKSAATLNPEFATVKIQRPDWKVGESHQYITAHIWDTAGQERYQAISTSHYRRVHGAILVYDVTSKNSFKEIYPGLSSGGLSWLRALKQNADPDILGGVMLVENKIDKVDKDQPRPPAYVQENEVTKLLMDVVYRDPVEGVGWLHNGKPDKVTPYRLANSMMFARASALTNECELFEMNERKAATVNEMFHKQSDLLGYEKTDGVSSVSKAIEALVLRIYERSKDMHAGGTKVKGKPFKLIKASPVAPTSADQCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XX44</accession>
    <name>A0A6G0XX44_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_000341</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XX44"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011498"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0745313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="218" mass="24961" checksum="8905D83ED26BDA0D" modified="2020-08-12" version="1">MCNTRVGSGEAPTFWNWHTAAGMKRKTVTWATTTIHEFKLGHNACSIPSTGGPSIGLVGPALASRTTQVDDRLSTPRPHNEQLLGPMQRIELLRDAGHSVEEIAHFCIATNQCRTERHETQQEYVAQMRQRHYETYVVRQQIMALEMERQRQLYLQMQQHQHQLQMQSSSSYPRSSTFYSTPYAAASQSPRYQYTSPSPEVQVLDNKRRRVSVEALLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XY54</accession>
    <name>A0A6G0XY54_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_000455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XY54"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017285"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0745438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="186" mass="21076" checksum="129E85B93F84D094" modified="2020-08-12" version="1">MVSTMNNVQAENESTAVEVPSYHELAESRNTSTTTFSTIISRASTRNTTSNDMFTQLVHISICNVLLLTPGYLMHTRFRSDKTSDECIHYNFTRVVLRSILFFTTIILYLPATGHARFQLYKLRDKPKAPGPVLERSFFLKLCESVALCDIILMFGTALLILLGAIYPAWAYDCQTDIQFFPRATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XY63</accession>
    <name>A0A6G0XY63_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_000465</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XY63"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017277"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019900">
        <property type="term" value="F:kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045198">
        <property type="entry name" value="CNBL1-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23056">
        <property type="entry name" value="CALCINEURIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23056:SF26">
        <property type="entry name" value="CALCINEURIN B-LIKE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="38"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="145"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0745449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="158" mass="18111" checksum="3C91C6E51E6211EA" modified="2020-08-12" version="1">MEDSMFVDRIFSILDDENTGMINWPKFIRAMSALEKGDIRDRLRFLFQVYDLNKDDSIGRDELAAFFISSLMVSTPNEDLQQVTRQFVDEILFKLHPTGGGIISSQDVLNYIERSPQEDLFSLFGRTMITDAERQRNASAADRPPGVDRLLEEDGCHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W2J8</accession>
    <name>A0A6G0W2J8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_019237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000540">
        <property type="protein sequence ID" value="KAF0721049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W2J8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005845"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0721049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="137" mass="14992" checksum="A36B4DB9B1F1AED8" modified="2020-08-12" version="1">MTNPGPTDPFRDPGHENPVDAAPLYSDDISIPPDLPPLEPIPETDDETDEGPQLESTPLQDKTRVPTKTFSEKSVTILPTQPDFKGHHMKSENDFPPVFTPAQIEAIVSGDFEGIIETSNIDVEDKMIPITAAEIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W4F1</accession>
    <name>A0A6G0W4F1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Crinkler effector protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_018746</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Host cell</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000351">
        <property type="protein sequence ID" value="KAF0722025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W4F1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019494"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019495"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043657">
        <property type="term" value="C:host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045379">
        <property type="entry name" value="Crinkler_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20147">
        <property type="entry name" value="Crinkler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Crinkler effector protein N-terminal" evidence="4">
        <location>
            <begin position="3"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0722025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="606" mass="69741" checksum="4C1CA8B60C4B4656" modified="2020-08-12" version="1">MKSLTCVVVGDGNLFTVDIEDDKSVADLKQLIQTKVLLLMVYDMDRLALFAANKGNLWRESGEDWLRLDEPAVQLLKQKTQSEISDLLKESRKMHPTERLGDIFKCAPVEDVLHVLVQVVHPERLQLPLCTDDAQVKNLKFSAEHNYHDEISVGQCYKMAMLEIEGRSSLAFHEKTIYCRQDMKNMLEALDKMERGIRINGPPGMGKSITTWLWVCNQVKKGRSVLWIHLLDCVSERIIQLTPSGASLIVPNDKLSFVEDTEDDIIVLDGFTEDHVSLGWRAFETRTNAHRQTITISNVSIKTKDEEEEYLKRTCFDMTPWKLDEYFAAVENEAFFTSVQPYLGMYADMKTAIDHKFYFAGLSVRWMFGMNRSQVIQDIAKCFDHCPNSAIVLSYTSLPRSELSLNHLSCDQGPDRIRFFTSQYIARLAMDRIGLDVIYLAYYHARRLYTSKVTGWVVEMDFVHQLKDASGRCLEVVLHPQDSKVYQGSSIRRRDSKVFGQHLVCLRWSRNRLVLRFVQVKSATKCELKLEHVNALALKLRDDLNVNIHGIEVMVAVPSDLSMIDMSFQGDLSEWFVGDSDERWDPQRGKDQVKVVEFEKSFFFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W5Q7</accession>
    <name>A0A6G0W5Q7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_019155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000425">
        <property type="protein sequence ID" value="KAF0721391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W5Q7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003932"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026330011" evidence="2">
        <location>
            <begin position="23"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0721391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="164" mass="17649" checksum="92C0C8ECBE7DF2A1" modified="2020-08-12" version="1">MARSSLLLCLLVALTSFVCVESRAMFHDAILEKVYAQVLVKDSEGKCKKEVMKHKVNQIATNCAAVSAAVGLGLACSGHSQGAAIAGGVATTIATFKAQVDSYIDERCARLEKAASGVAKVKKVLPKLKAVNAFNSLKKQPPPAEIRVPERAHLRRHHRLQGYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W681</accession>
    <name>A0A6G0W681_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_018299</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000330">
        <property type="protein sequence ID" value="KAF0722565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W681"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010858"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051759">
        <property type="entry name" value="LIM-SH3_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46218">
        <property type="entry name" value="LASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46218:SF4">
        <property type="entry name" value="LIM AND SH3 DOMAIN PROTEIN LASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="2"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="79"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="146"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="275"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="539"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="655"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="314"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="291"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="539"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="655"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="719"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0722565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="732" mass="82447" checksum="3299E8C6E915AB10" modified="2020-08-12" version="1">MAGLAIAEALYKYTPEEEDELAIEPGDAVYVLEYLDDGWCRGYLQSNPSEVGYFPANYVHAKKQPTVNSHLPPHKAPNRIARRGKAVYDYVPQEMDELELQAGDVVVILDTLGDGWCHGYLANDPTHKGMFPSNYVDIQADHWTTVANHNDSDDDPHWRRRISSTPPPISSRSRNPSRETSAGSAAAVETPLGSLTPSDSAEALVVNHVPPELRQTNSMLAHKYTPPPQESIEDQYDDTTQLRATKESTSVLLDDETQYVSSSQLYTDAEELINSRKHQTRDGGEGKVDESASSVQDTMANSSGMNGKLSLRSVVQLKRELRRARENADRALAARLAAEAQMQAELDARRRAEREAANRLQNQRENEASTIEIERAIQQQIQLQIGTQLPKEALLDELEVPLTSSYVHVEPRAHAVRIQRWYRHHHSTRQRRRQVEQNAAATRIQKCRRKYVTKSRLQTAVASRRVERKPPPSLSHDVAATRIQKRGRIYIARRQRRRLVALKQPKQTRVPRIVTIAKYAKAPVPKKQAAAASIQRTWRATRPMHSQQLPSKAKSTMQIPRRQQRAAAPPPRPPRASTPRGEVKERTSHPSVAILPVYATDVAQISQLAGLIANSVSIELTKRMQAHDAQLSQLTTSVLQLQHAIQTHNQTLERVYEREERRGKERLKERSPSKSSLARSYESLPPPAIQPSLPALYKTPAAVVHRKRPSKLPVLRSPTKARTKWHATPVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W6A9</accession>
    <name>A0A6G0W6A9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_018263</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000327">
        <property type="protein sequence ID" value="KAF0722664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W6A9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018203"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23106">
        <property type="entry name" value="EGF_Teneurin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="122"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="201"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="304"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="304"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0722664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="329" mass="34395" checksum="DB91B0BF28D52777" modified="2020-08-12" version="1">MIVAALAMAAHALHPVGKVCKATSDCPLGSSCVAGVADESLQTCVADQVCGGNLPGNCPGFVEQGSLVCTWIEQDPADCTFGRCKTFNSIPGIYKCLSIDRCNKATVHSGANRCSKSCEASNGLTCNGRGICQSSGPDTFTCACHRGWNGTRCDNVVDGRCEAGLGHCGLHGECNNGTCSCLDGYTGLQCEIPTSKNLTTTTKPSTNLPTTTAASSSIVTTTVPSATSGESTVPPTPNTTIAPTNMTNGQSDNHASQGHSDKTDLRNKTLPITVSVLSSVAGTIILLIIMFAVYARGLRRRAMRKNEVTESRLESQESSTTPREHIQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W7Q5</accession>
    <name>A0A6G0W7Q5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Condensation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_017962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000317">
        <property type="protein sequence ID" value="KAF0723091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W7Q5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007741"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensation" evidence="1">
        <location>
            <begin position="5"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0723091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="199" mass="22209" checksum="352C30488A67A26A" modified="2020-08-12" version="1">MIEAISNRNIPVKGIERMLGDTLSAIPTRITIDDAKDVISILQRVQENHIASLAHSHANLVDMKKWSGTSGELLDVLFVFQQSDAPKSAAKEHLPFVEELRATANYTVEVELSVINHLQCVNLGYDGDRISRTQVYLMMKEFQFTLGQVCDAVSSDGLASIMWELSPGQRQKTQDSSFHPDIPLPYELLERASNERAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W8C4</accession>
    <name>A0A6G0W8C4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_018240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000326">
        <property type="protein sequence ID" value="KAF0722763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W8C4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005107"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0722763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="627" mass="70469" checksum="F086BF1C2EFFA032" modified="2020-08-12" version="1">MSRFTGECSVEFSKYCRCKSLFESKYLRTHRAAGTKVLRCFPHCCPSHVYNSVCGTSIVTRVHGPVSTLQNTVTYLRFDASYEKPLEVGDTIDEDYVLKRVRRNTHSVGEWIASHYDVVDEKTLSRVCEFSPKAQSTLGWHYRWVGGSARQQRRAVHYLRAYVFVRESPMLRVVAVAQSTPFIVMSYRRACKVCQRQTPEDSRSGLICQCEGIYRLKGYALTSELERVQQLQAKLAMSMPPPVVTSPSNVVGRKEDALATIHFFITSFPASVLGPYLSYLDMMLRKSLDSPLASPIFSQIVTNSKHPSQKLAGWTQTMEALGVAAGVTIQLLPFLNSFSVIHAPSLLNKHELERSHETAINHIFNELTTALAPYNTTPHALADEILVLCAVLHADYPDAATICLQKCEKFHTSVSFKSFVAQMRESFMSHASPPQLVPSPSNRPLDGCWRYRSWSLYEMSPNQNPSVLTLIRGFVTAMTINMVRTSDTLFMRSQQCLAGANWSEFHLDGSPHVLRTFPSGEATMACFDGLLHGDYVAEVRDGAVYLSLYSWPASSMTQVGYTIHIRLEQMGASAMAVDIRVIGAPGKSKAVDYWCMTVDQRLALYDATNEYPVVKCRLDYEKMSYFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W985</accession>
    <name>A0A6G0W985_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ae201684_017327</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000293">
        <property type="protein sequence ID" value="KAF0723876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W985"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009058"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="10" id="KW-0229">DNA integration</keyword>
    <keyword evidence="14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="16">
        <location>
            <begin position="224"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="576"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="706"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="585"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="606"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="720"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF0723876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="749" mass="83613" checksum="7E9E3A4ADAFDDA81" modified="2020-08-12" version="1">MHDLELLAIKYALVKFRIYLLGSKPFVVYTDHASLRYAVKTPHISERMARWFSFFAEYNMTVEYKPGRENVLADALSRRPANLGPETTELSVVYHVHSDLHDRIRRGYRNDPAMKAIIAQLSETTSRSGPTSTLERYSIRDGLLFHQPTRTTTPRVAVPCDADLRSELVKEFHDTPSGGHLGRDKTHVTLARSFWWPRMFKSVARYIAACVVCQRVKSSPSVRAPLQPLQIPDDLWASVSMDYIFGLTRDNRGNTGIWTCVDRASKYLVALPVKASVTAEQSAKLFFDNIYCRFGLPTSIISDRDPRFTSKFWTALFSLVGSRLIMSTSEHPESDGQTERASRVIEDVLRSYAQSRQNTWSYLLPQVECAYNSSTNASTGFTPFYANYLLKHPRLASSMDNSVSSGGRFSWQTSMHSPDWEPSAREEELPARTIASVKHFAKVRESILLQVQDNIAEAQSRQSRAANKQGRRRNAFALGDQVLLHYSLVPKAILGNAKTRPQWFGPFPITKVISRTAYRLALPADWQTHDTVYVGKMKAYIPQVAPAPELSTAQPHDHLTVQPQAQPNLVDQSLVERVGPRRTTRLPSLQGSSVSRARGLDQKLESSSPRSSPRAAQREGHREAALSQPQALLVRTAPLGLEADSPGRRDVAKPNGAVAGAAQTTPANEYAPMTTRASATRDLANATDVVSTRESAIATPYARILRSDQSVRTFAPSPTRMVTRSQSRQLTSSVKRGRAKPMTRSRTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W9Q0</accession>
    <name>A0A6G0W9Q0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">IPT/TIG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_017312</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000292">
        <property type="protein sequence ID" value="KAF0723932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W9Q0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016092"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052387">
        <property type="entry name" value="Fibrocystin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46769:SF2">
        <property type="entry name" value="FIBROCYSTIN-L ISOFORM 2 PRECURSOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46769">
        <property type="entry name" value="POLYCYSTIC KIDNEY AND HEPATIC DISEASE 1 (AUTOSOMAL RECESSIVE)-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="IPT/TIG" evidence="2">
        <location>
            <begin position="7"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="IPT/TIG" evidence="2">
        <location>
            <begin position="714"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0723932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="806" mass="89052" checksum="3E94D685CBA19C50" modified="2020-08-12" version="1">MFGEEAPFRADSISPSCGPWTGGTKLAIHGSNFGFSASTSSTYLRRTDEIDVATIRFMHQDKLLATVNAHVTNSSKIECETVPYERPVLSATCETWGIVSLWITIHGSPYIECKQPFYYYIQPFIFDVHPRAISNAALLQTAPVNLSMRLTIADTPQTALTTAERDRIVQDMRRHPLNFCIRSARSSTALWRLNGNALVDDQASDGVPCSLALPRDLTPGNYSIQLAFNDFDYPSLPSNSSSSVKNSSNPWTTWHSHGQFTIFTPPTLLQISPSCCYFLQGQLLTIQCSDMVSQTADRMAIVHFERIDDGSTLRAQTHYKVLAAVTSPKALTIQTPRFHDAGFFRLRVSVNGGLDFSELPLSTTLLVYWKPCCEYVTPEYGVSMGATDLHLRISFANPNTQLRDQPNVALEDAAFEDRGAISVRFTAPHAPTSTTTRGAVTSDRKFIHCSTPRNATVESFRYSQLEAVALELTLDGVVFFPLTPKKPFSYYAPPKIRAFSTSQGPTEGGTVLHVHLIVPVPDHFPCELRFRGVKCVQDVAVKKSTDGLTLTCETPPWKFERNDPNSCGANMVMVLVELTLNGCDYESDFSEFVPCQHALFQGYERHFLYYTMPQLQTITPRCLSVVGHARIQVQGIGLADYGGMIQVAFSNGKMTKYVDGRIADKDVVACRAPPFPAGGVCLVSLALNGQQFTGEWTTSGHCIASDIQVQYIEEPIFTALTPTRGVTAGGTELRIFGQHFVDTGMVFVRFQVARNGYEQIVRGTVVEGVLTCVTPACPTPQRVSIDWTLSGDFDPADKIKPQFEFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WA06</accession>
    <name>A0A6G0WA06_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycine zipper domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_017989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000318">
        <property type="protein sequence ID" value="KAF0723025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WA06"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019479"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0723025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="24492" checksum="749E6C1E510B57BD" modified="2020-08-12" version="1">MRGAPIDALLVRRDDEMSGVSVDLFIVQITPQGAMRFWTFLAAACTAVVAFDQRRNDVQVMHPIASTTDVVHFKNRVLTAPGKANQVNNPRGKYERLGFKHGGRAGAAAGAIAGAVGGTLAGSAAGTAVAGPVGGAVGAAAGVTGGLYTGWIGGRNIGGKAGGAGGRVVDKLVAKQKAKAPPPGAGKKILTRSNAMKPSPNPPPKTFSAKKKPGFVSRLTDKFKNKNGVPHRGGPKLKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WA97</accession>
    <name>A0A6G0WA97_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_017144</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000281">
        <property type="protein sequence ID" value="KAF0724135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WA97"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015222"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0724135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="78" mass="9213" checksum="1437F55BC01B8A1C" modified="2020-08-12" version="1">MASKRHATKQAKPIALWCDESVKMLLRLGFRDMNERFTSARSSQMKKDVYIIIESHLSTVMQRKYDCNQVQSKLHQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WAB4</accession>
    <name>A0A6G0WAB4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_017186</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000285">
        <property type="protein sequence ID" value="KAF0724078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WAB4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004698"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050127">
        <property type="entry name" value="Serine_Proteases_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264:SF65">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264">
        <property type="entry name" value="TRYPSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Peptidase S1" evidence="7">
        <location>
            <begin position="18"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="105"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="109"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0724078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="198" mass="21173" checksum="FAA9C86CA1FA4A90" modified="2020-08-12" version="1">MRWKKPIRVVVVWLHDGLCWWQGRRRLVQGDSGGPLTVEQDGSEKLIGVVSWGLGCAEADKPGVYGRISAARDVIEPYLSGSPSPTPSTTAPVTTKLTIAPLKSPVTFKPTTAPSTSPVTSKSTTKPTPSPSTTKPKPTKPTTTPPSAGCGSCFYPDADYCISSFSKEIVLEKGERRLTLTLKSIYLLGRTSSQPVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WAD7</accession>
    <name>A0A6G0WAD7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_017093</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000278">
        <property type="protein sequence ID" value="KAF0724195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WAD7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014202"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052628">
        <property type="entry name" value="CFAP70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44314">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44314:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="440"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="453"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0724195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1056" mass="115770" checksum="682655D643B20229" modified="2020-08-12" version="1">MAEVAPTPQGSFTVVLGDIRWTNQADGDSVAPSYWAHVDVLSDLTLWWSGDTEYRASTSVISASSNDEDDGLPSFRYSQSSKLFPLSSPSPIPPLCATTVAITLYKGTAHDKTMDELVGAVNISLKPLVVRHESTEFKTFSDELSVQVGVAFDVAFVEAFQGAKALNFVRGAIRRVPQEWKLVPKEGEDAATLAANPEINAAKYTATIVFPSLEAGTPPVQLVLGGKLELDASLADVDQAWAVQLTPVDPSALWFLSKTQFEALERWMEDNSSASVSIQRVSSGETWLASSKLSFLDLFVPGTKAYNASAALTQGVAPTRESLEDAVAKAASGDDKKKAQAALNDYENLLTRIAGQAAIYISAGTQLCLEVSLLPDAWISLPPEPTPPPMTLAQLIPPRPRLPPFPPRDALASMHKELRKIISMLMKEYERLFFQPLKSRQGGDRTDYGDANQADEDDEDEDDDEMLTKEDRRQKLIFHLNAQGIYFDFKERLKKALVAVIRERFPALVATALTDKQAAKSEFYAQLYSYLMEEVNVVLHAVFDGNSIDNSSQTEPNFAAIQAKLAQMRLLAWENEVNGQLSKATTVFLDRIALVDAVPELQAHVWFDFALFSLRTQDFHKGGECLRQCIAIDPNHLGAVQAYGALLCQTGDFEAAEIVLKNALGLSPASPHEQVRGHALLALYYTLSRTDSTGNLRLHELLKTAKLDPTTAFRSPAAVCIRFAAYCKDLGLYSLAHEALAVVALVLKPKTALDTAQLTSQALVRAAIELHVGHFDAARDACQVALDMDAACADSWYLCGLIASRQGLFDAALESYSHALGHMERLADLYHLPLYLHLGALYMQHQQWGAAKAIFLRACHETSAASAWLGVGVVCIRQEDWEGAEMALAEANVLDRTNADVWGYLSLVCLNVTPVRPKQAEQALEQALRYDLTNATLLRELSNGFVALDKLEMAESLLRRSLLTADSSLTRKTLADVLAAQNCAATALEQYKKALDGCATMTERTTLLSKCAELLTTLGRLDEAQEFREIAMHQQQGAEKETLLGMQMQQPRQDVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WBA1</accession>
    <name>A0A6G0WBA1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_017603</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus outer membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TMEM53 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000304">
        <property type="protein sequence ID" value="KAF0723523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WBA1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013817"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005640">
        <property type="term" value="C:nuclear outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008547">
        <property type="entry name" value="DUF829_TMEM53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12265">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12265:SF30">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05705">
        <property type="entry name" value="DUF829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0723523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="249" mass="27485" checksum="4EE34363138BDE79" modified="2020-08-12" version="1">MPTVVFVCGWLGGKPRAVAKYAAMYHETLGLDTFTLLSTPSDYIQPASRVHAASFRDFQTWLANHHDTTTRLVIIPHLMSNGGCYSWSCFQNHLDRAGIAFDVPCLILDSALSAPRDSSNGPIAFTAAIKNRVVQHICAAILTVLMTVAVFLLSDVFGMEGPLEYNYNRLILRDAAIPKLFLYSRGDSVVNPNHIQDAIAKANELKTPVVQVVDFETSKHVAHLTLAPERYKQSVHAFVGQFVKLKSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WEA5</accession>
    <name>A0A6G0WEA5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_016411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000253">
        <property type="protein sequence ID" value="KAF0725013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WEA5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000045"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0725013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="920" mass="105927" checksum="C4128C3FDA2007C5" modified="2020-08-12" version="1">MFASHNAAARRASAPSSLSSRHSEHVKEEEIRKADDTSPEEPHHEVENEDKNQDEDKISYDIVCGDNNNQEDDEIYHEAPSIAEVLPADFIDLKDIRLDNFEKNPPPLATSWIISWDKRAVWPQALSDACPFIKGSFEFDNHDKVAQAALNYSAILTARQHRARAHNQHVALSRLRRQDAASAIAKAKSQDIVERLDSASERRDLWLAIQSTPLSSNQLPSPELIQDESLREFSQRRITLAQEAREQLLSQRSARSGAAVDRAKAIAADIASLHEQYKELAAQDLQDRLTRASMRRLILLDKRRLIAGRHSNYVKSVYLTNRYMERREAEQLEINMDAAVARRDANIEAIQSNARRHNLSTQFRVSCAFRLFDAKWLNQALRNTSAQQSADLRRDQLLQARLAALQDAASRRFHVMCTRRQQTIEKANLVGAALQKRLDEAAIRRQIHLTMIRQRIVDRRELIRARKIHFAHQFKRYAKWFYLDKVDQAKKRREAWLEHRRSAAATRNWYAKVLAHRQVEARIESSESLALQVQEKLEAAASRRFEYQRPLFSELVNLRGKRVEHVLGAHKQLLTRLSARKAALASIRLAEIDHERATARHAAWLHVQQVKERREHDQVFRQQCIASHAFARLRSAEIRRALGYEAIRVAAEQNRERASAARLRVHIRLHEQKAFMEFRLIRAEEKRAIRLAEKVSPAIWFSSQGEAARNRQLLRQETRRVANQQSLQEAALRKAIALTHRARKHFVERAIVSTRQNCIRIALAEKDIIRDTKFKRADARRMEILAAKQRSAHRTIERVVLARLERQSTDIVDTAIKTAMNATVALQAEARRVQILQSKQRSARERLQVVNANARSQRAKQRVQSAALLEQSQSRLDETTKRREALLAARKVGQSVVERLQPFAGLRVEGKAMTLWPSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WEQ1</accession>
    <name>A0A6G0WEQ1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_016539</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000257">
        <property type="protein sequence ID" value="KAF0724888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WEQ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002785"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="53"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="238"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="363"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0724888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="571" mass="66947" checksum="5E980533F7A2A61D" modified="2020-08-12" version="1">MDHMAISVQLLREDNEALEKRVAEMAKEKEAWLKNQELFEKQIKKLSELNQLQEKRLTEAPPAKPSAEVKHEMEQQRKKNDTLEKNISHLQRDLERVYKRLQDQKAPSTSSSRIDYTPLLKQKAEFEEQQRVVQDLLRQCKEKLKDRHLHKRKRLDNDEQEHETLLKQAIDHYRSELDDEHEFKAMDIAQMTQELDETRSKCAKLEEENNKGRAYVASLQESIQRERNLDATVWQARAKALGEELAQQESAMQLLKNNMQELQDRLAVKEQYLQEQEKGLLEMVKKQANDKLEWETAEAAYQKQIQLLQVELQRRNEELVKKRSSEQSSETEIKRKTAAIEEKYQAEVQHLQDRLAVKEQYLLEQNKDTMAILKKHADELLERDEAETELKKHVQSLEETVVELNSRITESDQHRRSLDLQLQRLSTQMAEKDLAVQAVEKSREDTMTLLKQQIEARQKKEEEIVGLMGQLNGMKTQFEDAARHQSDARESNVKNGKTTMPCLSSQASEELQEFFLAYYDCAETKYQAQSEASDALRSQINNVRRAIQDLLPRMENDQTRASLAFALDKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WFA7</accession>
    <name>A0A6G0WFA7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_016454</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000253">
        <property type="protein sequence ID" value="KAF0725056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WFA7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018430"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018431"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0725056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="424" mass="46745" checksum="B2BB9CBCE841426B" modified="2020-08-12" version="1">MGGLYAEAKLGLEVLMNKWHSEGWEHYLSIGGAVIGWTRGTGLMAGNNNVSVGIEKLGVRTFSHVERAFNLTSILHPRIVAAAAKSPLWVDSGGGMARLHYAQFPDLPAASELATLGKNYKGMINLEKTVVVVGFGQVGPWGNSRWEVESYGMFSLDGCVEFAWVLGCIKFLISPLKSGEHYIGWVDAKTQDPVADTQVKSLYAENILKHSGIRVVEPELFEGYDPKKKIILQQVDKNMRPIEVASREEGLESQKLRQGAVLSIPKILHLNRWVAGQIPTGWDAKRYGIPADVAEAVDPITLFTLVSTAQALISAGITDPYEFYQYAHVLVTHFGHVDALAIATDPEFLYDHDMMDQVVAKKMNQAQLYWGHDYYLGEPRIAPLRAASSLAMRTTTTLHLSSARTTYLCIPTAAYALMASRPHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WFM9</accession>
    <name>A0A6G0WFM9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_015827</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000232">
        <property type="protein sequence ID" value="KAF0725865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004385"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000289">
        <property type="entry name" value="ABC transporter G family member 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000528">
        <property type="entry name" value="ABC transporter G family member 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="428"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="463"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="507"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="544"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="577"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="663"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1079"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1112"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1152"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1191"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1221"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1321"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="68"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="743"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="700"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0725865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1348" mass="150849" checksum="DE0377198B230BAB" modified="2020-08-12" version="1">MSKSAESFLADGSDKFHDMLANNLETATGKAMPQVEIRFKDLSIAADIVIATKDGANELPTLANHAKKSLMGLAKSKRVFHKDILHPVSGVFKPATMTLLLGQPSSGKSSLMKMLAGRFPMEKNITVGGSLTYNGASKEEVKKQIPQFVSYMSQRDHHFPQLTVQETMEFAHQSCGGVVPQRVLDSLVSGTPEENAQAKEIIEALYQVYPDVIVRQLGLINCKDTIVGNAMLRGVSGGERKRVTIGEMEFGMKQVSLMDEISTGLDSAATFDIVKSQRSMAKSLKKTIVVALLQPSPEVFELFDDVMIMNEGYVMYHGPRAEALSYFESFGFKCPPNRDVADFLLDLGTPQQHQYVVPGMTNVPRYPADFVVLFQESTIYRYMMEHVEGPVHPLLLHDADHHMKEMPEFQNDFMTSTMQLVRRQTKVLLRNTVFVKTRAIMVIMMGLLYSTTFYQVNPNVAQVMYGVIFQAILFLALGQIALLPAFMDAREIFYKQRSANFYRTLSFVLAQTITQIPFSVAEAVIFGTIIYWVSGFVSNVGSFFIYELILLMTNILFATWFFFIAVISPNLHVAKPLSMVSVLFFVLYAGFIITKTDIPDYLIWIYWLDPIAWALRALSINQYMASEFQVCTYRGVDYCKTNNGKMMGVVQLKQFGMPTGKEWIWYCVIYLVALYVIFVAMSFATLEYIRFENGHGIALSEEQSKDQDEDDGKSYTKMPATPAGSQASDSVIVPVQEFVPLTLAFKDLHYFVPNPTKGEPDLELLKGVSGYALPGTVTALMGSSGAGKTTLMDVIAGRKTGGKIVGDILLNGYKATDLAIRRCTGYCEQMDIHCESATFREALVFSSMLRQSSDIPTATKLAHAEECIRVLEMHTIADSIIRGSSVEQMKRLTIGVELAAAPSVLFLDEPTSGLDARSAKIIMSGIRKIASTGRTVVCTIHQPSKEVFEMFDSLLLLKRGGETVYYGDLGRKSAHLMEYFMRIPGTPEMAPGYNPATWMLEVIGAGVETKVTNTTDYVQVFQNSEEYKQLQAALAVHTVPRADVPEMSYTSKRAATNAIQCQYVVQRFMRMYWRTPSYNYTRILLSAFLAILFGITYLSFDYTTYSGVNGGVGMVFMTTLFIGIISFNSVLPLSAEERASYYRERASQTYNALWYWVGSTVAEVPYVFVSTFVFTIIYYSFVGFKGNVGDVIVYGLELSLFVLMNVYFGQLMAYAMPRVDVAASMGVLLNSIFFLFMGFNPPESQIPSGYRWLTTITPPKYSLSILVAQIFAKCENGEGMGCHTMSKVPPVILTELGKENVTVKEFTEFLFNMKYDNTVKYTWVVLAIIVLFRLLGLLSLRYINHQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WH17</accession>
    <name>A0A6G0WH17_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_015320</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000216">
        <property type="protein sequence ID" value="KAF0726432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WH17"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019069"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="69"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="134"/>
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        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="256"/>
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        </location>
    </feature>
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        <location>
            <begin position="288"/>
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        </location>
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        <location>
            <begin position="353"/>
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        </location>
    </feature>
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            <begin position="386"/>
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        </location>
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            <begin position="418"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="450"/>
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        </location>
    </feature>
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            <begin position="482"/>
            <end position="514"/>
        </location>
    </feature>
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        <location>
            <begin position="515"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="547"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="578"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="611"/>
            <end position="643"/>
        </location>
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    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="644"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="676"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="780"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0726432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="815" mass="89206" checksum="74CAB083E47DB915" modified="2020-08-12" version="1">MFWQSHEKKLYAAIEKGKEIKVKKYMAKCDNNIANEDGWTPLHAASYYGHADIARFLLQTYNIDQKDYTGRTALYLASEAGHVDVVKVLVAESIKADIATNGGMGPLHTACWNGHLPVVKILMEHCNANMKACLGSTPLDMAASQGKIEVVRYLVSKKVDVQAVNSNGWNALHSASWWGQAEVVRFLMQYCDINQKTNAGNTALDLALERRRKEVVMILQEKEESHFTLFDSVRLGRIDLVRKVAKTSAIHSLDESGWSALHVACANNQDEVVEFLLGHIDVNLQTKEGATPLYVAAGNGHLKIVIQLIGHKANVALSHHSGWSPLHIASSKGHVDTVAHLADCIDINLPTNHGSTPLHLAATYGKLEVVKCLIAKKANTHAVDTNGSSPLHDACANGHIDVVGYLIDYVDVNFRNNNGQTPLYQAAHSGKLEIVKFLLDKAQVGAVSNNGWTPLHDACANGHLEIVKVLVNYIDINARTKDGATPLYVAAGNGKLAIVNFLIEAQASVALPSNIGWTPLHSACYNGQLEVVKVLSKLIDLNSLTKAGTTPLYVAAGSGRLEVVTFLLSQNVRFSDQNGSTPLHRAASNGHLDVVKLLLDHVQDVNLRTQDGQTALHKAAQHGRLNIVKYLMTREINYEIVSHSGWSPLHSAVWSGHLDVVRMLVEYIDVDIQTDGGATPLYVAAGTGNAAIANFLLAKNANVTLPTNIGWSPLHVACSLGHFDVAMSVAEYVNPRLTTSIRWNASKTAFLDGSPELRQAMADKIQAMLAMKRNVVQRYHKPTKELDDPDEWERESELTTEGTMYSYDEQKDGYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WI06</accession>
    <name>A0A6G0WI06_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_014969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000205">
        <property type="protein sequence ID" value="KAF0726826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WI06"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014448"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0726826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="365" mass="42481" checksum="383B99A282AFAFA9" modified="2020-08-12" version="1">MLAAPSKSKGKKVGRDLTLVSKQQAAKTAAATKRKQDQRAREKNEKDSLLTTERELQGMIDMLMKRFKYPVVILNQLPTEIRDAVLENRERIRDGNDMKKRLQELYEVQQILSRWVFAHYPHEPKPTMMETTLLGHDECRQFGHLWLCQKGLNMALTAHPYEPFLGKVDDNIISWPHMGEDDTGSAVEAVQFHSQYSVMGDYRDVAAVLWDTYHTSSPDHIITIVEKVNDDCVYSCVEYGPVRSKILHLAGIFRLKHRIIVTITVIAYDERFPMKDGETRIHGFGWMILDEMGDKVTLCRQSHLQYAPVNKDRRLTLEELGQMLHYRPEPREPRENVVVKFQEMVENGYTLQRDYQIRPHFPVMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WIK1</accession>
    <name>A0A6G0WIK1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Condensation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_014779</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000202">
        <property type="protein sequence ID" value="KAF0727039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WIK1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005824"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Condensation" evidence="2">
        <location>
            <begin position="4"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0727039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="217" mass="24158" checksum="1F534C4226485D78" modified="2020-08-12" version="1" fragment="single">SVDHDTILSSAKLIGVPLTIILQYAWAATWRKYSKRNAIAFVQTMANRTLPVPDADKIIGPLMNESPFRIRFDDDSMPIATQLRVLYREEAKLTAHSHTSTSRIETWCGTPPGRTLCDTRFVYQNFPHMENSTSSGRPQFQVTTRNKELLQSVGIDTAAIEASQQSQFTYMIGIELNGNNIVAKGVHDPAKMSSIQAEVILSEFDKTLLDILAATKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WIV2</accession>
    <name>A0A6G0WIV2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_014764</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000201">
        <property type="protein sequence ID" value="KAF0727127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WIV2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006383"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047150">
        <property type="entry name" value="SGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831">
        <property type="entry name" value="LD24721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831:SF2">
        <property type="entry name" value="LD24721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="317"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="57"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="121"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0727127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="629" mass="69755" checksum="35FC518BEDC72C96" modified="2020-08-12" version="1">MTNDKEGEIEAWTSKLAVNAKNALALRSRGTLYLELGRADDAELDARSWLALEPKVGAAHGLLGVVLMAQRRFDEAVKTYKHGIQADPKDETLHDRLRRARIAVIDELAADEDIAILHPATREPPQPATSVPSAPETTTPLPPLPRQESSNSSINPSRTMTTPSTELQNFSGQPVSTLLHLVLRLVWLILLDLHRSSPHLSNAGLLVAVGIVGVCVQNWLGLLLLAVAAIGLVYMPSSWRQSIVNVLSRRLEQWMETSSDKLYTISLIPCMLACVPMVLKVVGLYNLFWFIHQDNYLALGLLVYFVVVLHTKQSPKLVKAGMYLLIVLYWVVYRRHHRDMFRFIPPASFELASFILAGISPMQVQQATKRSLATLLTELSPHVNLWGVLALGHWAVDFWSQPSSFTIEDILASFRKVQGSAINLFQTEIQAYRASHDGRSSATSSSDDYAVMVAYVAKTIRALPPSKRVAAIVMVLQRCVHTVVFLLLFLRGHICLALMPLMAQEIGAFQGIVHAFTEFDTSECDTLDIICNQSPPLLTVWTNVKAGVYCMECSVTATKVAVAATSATLLATQLSHLATTVAAVRREGVVHHMDNLIDVAATLFESRHLIQPIHEAWIEVTRRWWARPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WKR9</accession>
    <name>A0A6G0WKR9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_014214</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Phagosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Early endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000187">
        <property type="protein sequence ID" value="KAF0727875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WKR9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010988"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030670">
        <property type="term" value="C:phagocytic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048869">
        <property type="entry name" value="OCRL-1_2_ASH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF300">
        <property type="entry name" value="TYPE II INOSITOL 1,4,5-TRISPHOSPHATE 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21310">
        <property type="entry name" value="OCRL-like_ASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="6">
        <location>
            <begin position="562"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0727875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="726" mass="81554" checksum="7B77C7EBC051266A" modified="2020-08-12" version="1">MMDFARLSSTMGLSSPSNAAPPPAPPQPSQNQTNVRFNHPVVLSQIREDCMAQKLHLRASEFTEVKDMNLWTGTFNVNAKKPVSVAECAKLLYWLRVNQEDKTAPDVVAVGFQEIVDLNAVNVVVNNMSGPRSSQWEESFLTALNSYVSDQAYDVIMNKHLVGILLLVFVKRVHLPFVSDVLGSTAGVGIMGMMGNKGGVAIRMKLYDSTICFVCSHLAAHTHNVMGRNSDFANIMTKIEFRDAVYDEMNPLGYPDPSAHILTIHSHDFIFWLGDLNYRLVEDSSFTVDDCFAHVEKRNLDVLLARDQLNQERDKGNVFQGFEEGKIHFLPTYKFQAGTSFYDRRPEKKIRAPAWCDRILWKAKQPETVDLRHYGAAMELDMSDHKPVAAQFRIKINYEVEEKKEVVQREINRELDKWESDNRPKISISDNNLLHFDAVSYMIPQTKSFWIENTGLVVAHFKLAPKLQDAPITKPWLTISPTYGMIAPKEKFELKLTVQVNMDAVHALSSGQDTLDETMILRIANGGDKFLVVSGDYLPSCFGCSLEQLVVQTEPVRNQTPVPREAAVSQKIPKELWRMVDALYSQGLSAPNIFLDTDESEASALRAALDTGAPFPIHRPQSMAALLVHWLQSLRESVVPESSIGPDCSARTIIDSLSTVHYNVFIYIVSFLREVLLHSARNLLNSSKLAHVFGRCLLGYGVTQSPTPKIEVMERLISHFLTTGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WM37</accession>
    <name>A0A6G0WM37_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_013731</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="VJMJ01000178">
        <property type="protein sequence ID" value="KAF0728366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WM37"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006728"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000022">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase CYP95"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="8"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="170"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0728366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="213" mass="23504" checksum="CF220B19708C1E8E" modified="2020-08-12" version="1">MPAETKVFFDMEIGGKKSGRIIFKLYADTPKTSENFRALCTGEKGIGRTTKKPLTYKGSIFHRIIDGFMCQGGDFSNRNGTGGESIYGAKFKDENFIHKHTKAGLLSMANAGRHTNGSQFFITLAPTKHLNGKHVVFGEVISGMEVVRAMAAVPKGRNDKPTKDVVVANCGELTEGSEEKKGASKKRKNDDDDEAKDEEKKEETKKPKKKKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WP90</accession>
    <name>A0A6G0WP90_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_013130</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="VJMJ01000167">
        <property type="protein sequence ID" value="KAF0729152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WP90"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004289"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967:SF57">
        <property type="entry name" value="AUXILIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="54"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="332"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="462"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="470"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="518"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="549"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0729152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="567" mass="62384" checksum="908233807BD96919" modified="2020-08-12" version="1">MYESYIRYLERLQVDQEKLDHFVFFVARIKQENGEMGNVHAQIGRVGTIGRHTVEVTKYLGEGGSSFIFLVKDTSSSQTLVLKRLVANDAMYMELLKNEIEFHRRFKYPSIVEFVDSQINKSRSEQEVFILMEFCPGGHLYDNMKKMGEKRFTLEELIKTFRPLCIPVQYLHRQEPPIAHRDIKLENFLLAKSGVYKLCDFGSCVEGPRVLTTKEDRTTEIDIVEKRTTAMYRSPELADIEGTAMFGSGVLTEAVDIWALGCVLYTMAFFKPPFPPEGLRTSKYTIPSGHSYGKDVPALIQRMLCEDVEERANIDEVIACCDAILGSQPLPKRGSVAKSTSRPNSGSNSRTNSGEKGNIVVDEAKPSRVNSGKAVDLLNVSAPAAPVAPVASAAFADFADFPKSSFDPFAAQPAPPPATSKVVDSFGFLVSPTNNSSVKQTEARDVFQAFEECNQPKLMPWQATPQQNVPGGYPAQGGYPAQGGYPAQSGYPAQGGYPAQGAYPPQGQPSMGGFQAFSPMSPQGNYPPSQFGGFPQGNANPISPMAMHNMQSPPSNGSWKSSYEFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WPJ9</accession>
    <name>A0A6G0WPJ9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Retrotransposon Copia-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_013062</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000166">
        <property type="protein sequence ID" value="KAF0729316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WPJ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005851"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0729316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="17405" checksum="91F59A2BA6F680C6" modified="2020-08-12" version="1">MSEQQPVGPQVVPSSSHNDPVKAVGAVKWMSSKNFDGNNFHYWMKAIRNHLKAARLWEVVIGTEVRPAAAHLAAHWDHLDRLAVAILMDSIRDDLLLGITGEETAAMIWAFITSKYHDVKWGTSAGFLGKLTALKMTNGSNVNDHLTAFKELSEKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WQI9</accession>
    <name>A0A6G0WQI9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Doublecortin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_012768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000162">
        <property type="protein sequence ID" value="KAF0729708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WQI9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020020"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.230">
        <property type="entry name" value="Doublecortin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036572">
        <property type="entry name" value="Doublecortin_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89837">
        <property type="entry name" value="Doublecortin (DC)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026243052" description="Doublecortin domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0729708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="259" mass="29298" checksum="5DB0365681B67DEC" modified="2020-08-12" version="1">MWWRALVVLLAVVHDVFGVPVVVFPNGKAVGGRTIDLTPDQFKSRQALAAYLSTIAALDYHGDRVYKASGELVESFDQLVEDDHLYVVAPGMELLVSAPVTQVEEEVSTQARLTFINKYDFPVDVYWFQKKLYPLDKGETQAFRVHHDDEIFVQDAAGNVLFEHHVNVHHSNDLEFTLPGGISIEFRNQFESDPVDIYWFDRLHGKVGPKQTIVFNSADGNEFTLRDSRGNHLAKVVLQDAYGPHQHFAVPLDEGHQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WQT0</accession>
    <name>A0A6G0WQT0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb/SANT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_012662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000161">
        <property type="protein sequence ID" value="KAF0729771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WQT0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015222"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0729771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="31214" checksum="ACEA000910BABFBB" modified="2020-08-12" version="1">MSKYAHIIAIADKSIGGQANPVSDPRPDPTPSVSAARAPAKYGSAQKGKGRAQAVWCDSSVELLLRLRFADMSDRFNGARNSQMKKEAYGMLADELSTAMGREYDHNQVQNMLHQLRKSWFHPKHKPTGNGKNVKSKPQYFDIMFEYWGSKPGYSRDSLLSSDTNAAIQTIDDNDQDSERSSENFLTSSDTEHNPGNSDENEAISNMKKRSKPEHFSRPRANEAIKKPKTSGSQADSILRGLEAVGTGLQSLGTALTAAPVGTGDNVAQEIKLLCNAKPMLLRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WSA4</accession>
    <name>A0A6G0WSA4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F5/8 type C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_012311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000155">
        <property type="protein sequence ID" value="KAF0730312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WSA4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018371"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026187291" description="F5/8 type C domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0730312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="24478" checksum="B7EA211F0212AC8F" modified="2020-08-12" version="1">MRRTASIALALLPPPCVAIVSLPNMEFNAALGQIPYASSHYAFEFNPLLDTKYVPGNAIDGLVIQTSWWSSGAYNESVFFQVNFTTQSPVISKIIIRWHGYMAAKSYEIKTSFSGIPGTFVTFNTFEDPSTTWDRIDTVTPWINTSTRFTYLRVYMYSPIECNANNTVRCTTRRLGDMQQGPIYGIRELEVWAASQKSAAEGRPWVQFLAAFLALVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WSD9</accession>
    <name>A0A6G0WSD9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_012104</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000154">
        <property type="protein sequence ID" value="KAF0730402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WSD9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005957"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0730402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="138" mass="15421" checksum="DA3D78EEFAB135FC" modified="2020-08-12" version="1">MMMPFTVYKLSAAQTKMNPINLDVENAKSAPMQTASHENLPYAIAITRTRAIARMTESHWSSVLFEHDDSEDDAKDGVDEAAEARFNDVVVGDAPQEKAPHATDRPTTSAFRLERRVEEHFQVGLPQKNGMRIATHNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WT48</accession>
    <name>A0A6G0WT48_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Phosphatidylserine synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ae201684_012035</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000153">
        <property type="protein sequence ID" value="KAF0730616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WT48"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009649"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106245">
        <property type="term" value="F:L-serine-phosphatidylethanolamine phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006659">
        <property type="term" value="P:phosphatidylserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004277">
        <property type="entry name" value="PSS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF7">
        <property type="entry name" value="PHOSPHATIDYLSERINE SYNTHASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03034">
        <property type="entry name" value="PSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="402"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF0730616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="433" mass="50095" checksum="1F6C42D1F0DF8B8F" modified="2020-08-12" version="1">MTLEVDVPNSSVKLAKSSDPLVYGDLETVQNVDDGSWTTRPHTLLVGFLTLLYFVYALVTQDPSTSQVDDLKSGVKFACIFFLVYCVLQLRDGHFIRPHPAIWRLITGVFILYEMLLIVILFLKTDDARQFLRHYDPSLGVELPEEGFAEDCRLFTPEHPTNPMSNLSATFFDRFVVMHFLGWIVGAVMIRSYNVCWLISILFELYELTFAHWLKNFNECWWDQILLDVLICNAAGIWIGMRICRYFEMKKYNWVGWRAIPTVTGRAQRMVAQFTPANWLAYDWKMFRSASRFWQVMFMVFTLSIMMLNSFFLKTVLWVPASNSLNVVRLSIWYSAGSYAIAEYYVFMTYSVPTEPTRVPAKKLGPRAWLGLGVVVTEIAIILKHGRGMFTEPFPPLVKLGWAIAFTIIFLGSTVYFMCIRRDDENNTKKKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WTK0</accession>
    <name>A0A6G0WTK0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_011822</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000150">
        <property type="protein sequence ID" value="KAF0730820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WTK0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000884"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003232"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006168"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016215"/>
    <dbReference type="OrthoDB" id="59047at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="START" evidence="7">
        <location>
            <begin position="104"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="277"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="349"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0730820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="381" mass="42997" checksum="B554E78E6B7216E9" modified="2020-08-12" version="1">MGVKKLFPLPEGFFHAPPISDLERFQYIRQGQKNLLQFVAKARLRGGPIQWTFDHEANGVMVYRGKDLSLPAGRQVVYLNVTEVEATLDEAAAIMSAGEDGTRDYCATYNRDEIVDLKLLYQLAKAVPEHPHNSVTIKWRAFTTNTPMISPRDMVFLEFCDDFTLDNMKGFGRVMTSIELPEIAPDLQKPLGVVRCHMYNGGDVFIQNPKREGYLTAFRLYQQDVKGALPPWIVSRIAKSLVARCHATLELNFRHERVLALEFANELQPDEALAVPKDTRTHCGLCTQGFTAVNRKTNCYKCGEVLCKSCNLTWAIEVGRRIGRNRPVKRYVRVCLVCSANPTLRNGRHSAYTTGTDIEGSSKASRSVVSDRPRRAKSFHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WU23</accession>
    <name>A0A6G0WU23_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_011717</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000148">
        <property type="protein sequence ID" value="KAF0730955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WU23"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009307"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="3">
        <location>
            <begin position="25"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="25"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0730955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="299" mass="33355" checksum="D39130021EE4701F" modified="2020-08-12" version="1">MTRQDAPQQQSTATTAATTTTMIEWTAEEVERFHHALSVFEEGQWKEIATYIGTSRSPQQIQAYYESCIAPTKRSGGQRRRRSWEDGHARGGPATPSTQARPNYLHPPPSLARPFLPSPRHTPTGSSSANGRRSMEAMFNGVLDLFPGTTFRDKLIKFYYEYNPSKVNEVDQILIQFRNREVRLFLNLAVKYRLTQNLPPELVDITKRNLLRATTPKQSQDSNLRMLSSIVPSSTTATMTNGTSSSFLTRPIAGRVSPTESLPTLRSYVGQSTPSLPPVSAAMDVPTWSNPQPPAPYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WUG5</accession>
    <name>A0A6G0WUG5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_011690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="VJMJ01000147">
        <property type="protein sequence ID" value="KAF0731149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WUG5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009591"/>
    <dbReference type="OrthoDB" id="60843at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF1">
        <property type="entry name" value="PROTEIN PHOSPHATASE PTC7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026340292" description="Protein phosphatase" evidence="2">
        <location>
            <begin position="25"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="70"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0731149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="360" mass="38917" checksum="ABCD70365FE8BF8B" modified="2020-08-12" version="1">MTKSKWGWRQVALLALLLVQWTSAESPASTNFEDYGTCSLDEAGSVGCKSSVSLDVQVGVGCKPKKLNFVAGAESSDAAKNCGEDAYYVVQDSRYVSFGVADGVGGWQESGVDPSAFSLALVEGAKIDFERADESPRPQNLLESAFAHVKAGGDKNPGGSTAVFLVLDRSTGVLETANLGDSGYLVIRQNQKLFRSVEQTWAFNAPFQLSLYPSSMGESVDHYLPNDAFVTTHSLQHGDIVIVGSDGLFDNVFDEEILAEAEKYLNDVFEAHQEYKAQLEQGDITKPLPKDVQASVKKAMEDLSFALTDMANEFAHDSTLESPFSKLAREGYGYEFSGGKVDDTTVVAVYIHPQDTSPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WUN3</accession>
    <name>A0A6G0WUN3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_011436</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="VJMJ01000146">
        <property type="protein sequence ID" value="KAF0731170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WUN3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019790"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00156">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08215">
        <property type="entry name" value="STKc_Nek"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000535">
        <property type="entry name" value="Serine/threonine-protein kinase a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006869">
        <property type="entry name" value="DUF547"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04784">
        <property type="entry name" value="DUF547"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Response regulatory" evidence="12">
        <location>
            <begin position="7"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="152"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="9">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0731170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="888" mass="100196" checksum="C7026E6B985A28EF" modified="2020-08-12" version="1">MNPSEVHVLVVEDDEFTRMATIDILKSIGYVITAVENGGDALKKLTDDPTRYDLVLCDVMLPVMTGIQLLECVQKEIHLSHIPIVMTSSNEEMDVVTSCLSKGAKDYLIKPIQYNTAKTLVRHVWLSRKSNNDGANRLSSANSNAASIWRDLEVLRTIGKGTHGTVVLARRRGDGAVVAVKRVRLAATSENGRKQADNEVILLKSLYHVNIVRFYDSFILDNDELNIVMEFSDGGNLRQVVKLRSRMDGGYFPEPLIMSWFAQLVLAVSYIHGKNVLHRDLKAQNVFLTKKHVVKLGDFGISKALSGDDLANTSVGTPESMSPEICRGERYGKKSDIWSLGCVLYEMTMLKRPFEAQSLPEMFAKICHGEYEPIPTNFSKELRLLIQLMLQQDPSKRPSIEDICRFPFVQAPIQVFLSDHAAEFELALQTEARMNQAPIDDNMQVTPAASNFTQEDVAMMMPSPPSFNHSDSLREIAISSQVVGLDIHKPMPLELLSRSFEPRQETLSLADRLRCLVTPTEVKVNIFTFHSMVVTGQDLVHAFETDYGLQNHGAPISREALLEKALNAIHGLLQAKALHLVYGSSHLGSSDNLFRFQIDQRDCPMNMRYIATGGPEQPLELCLQVRAMIAELHAHPKFPAGIHLHWSLTTAAVDSSARIFRQFLQAIAAFQTLDISKLTSKDRQVFFINIYNTMVLHGVIEIGLPQTSEQYKSFEKEVAYRIGGMNFSLGDIRHGILRCNRKPPSAFWGRQFETSDPRLAYCFHTRDPRALLALIEQTPPFPSAAEAPIVNPRQADTDLENFMHMFCQKQVAMDIPSKSLRLPKVLRVYMDDFGSSETELIQWLAQYLDNCPRDIFMYRIRYAPGIIVHTHAREKKRQCKLMDRPIEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WVG8</accession>
    <name>A0A6G0WVG8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fungal lipase-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_011173</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000141">
        <property type="protein sequence ID" value="KAF0731550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WVG8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011658"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051218">
        <property type="entry name" value="Sec_MonoDiacylglyc_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856:SF24">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026260582" description="Fungal lipase-type domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="425"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="460"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="487"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="527"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="3">
        <location>
            <begin position="710"/>
            <end position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0731550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="935" mass="104947" checksum="E6A647894F694B81" modified="2020-08-12" version="1">MVLSMERHFVLLMALSLVSVQAVIELPDTCSGRGAFGLYQREAGCAVGNCDCFPVLFQCDDSLAHALGQCVLSKTGWAILIGAFALNLIVPAIAFVTHLLHRMKVEKAKAAKAKEDADLEAAEGSAAKYKTYFIDIKQFQTIVPDTAFGLHEEPKIFMETMNKGWVQLVCYCLAFSFALSCLMLIPSFNMNEQTSTLSRVATVQFDDYSYSIESVSMTSLPASTRYLSLQGDFCHESSNIMAPDGISIVTLNYSISFDMESKKIFDNVQGSKTFACECVQSNCDMVPDQSDNGLVELVYFPWFQDADHDLIRPFTKQTESHNFTLRAIFELTSDFTATQAVQPIPHLTFMAHYSYIQHVIDLVNVLVFVLDLVVLLLWACMTWRVEHKLPERSLIYVILCVNLIATFPFMFLAKYFFPSMSLQSVYLFCHAWFAGSSGVWLLCLLFALDMQRKRVFGLRFYLVKLTLGTVVLGLYMSVYYSLLPYQWILMLNFALAILVSAIFRGVMMDVRNKLRYQCYVSTRPEQLTARLLYIISVAVTYVFFFVALTADPVPRVEAYLPKTVHLTDMSVQVIIRTSTWILVIIFLPPTAASPNVYYTRARTSLPRLTDGSMHDFELASLKQAVHSRGLFQSGFVDWRAPRAFCVETACTAYNQSVAVYDEVVANPTTGGYDIPSHAHFAADGLEFVSELFDKATDTYGWVLKGDKKVVVVFRGTKSGQNAVTDLKYRFCTPGWCSDEEGLSETRVHSGFWEAYLTVRDDMKRIVQETMATMPEVQLYMTGHSLGGALATLASFDVSTDRDFHLGEEVVLYTLGAPRVGNHKFAAIFNRKVPNAYRICADGDAVVGAPKRSIQMAYFVKSLCYKHIGTAVLLSTRARGVFMINPNIVERAFMAEFRNNVLAHLPPMYRHLLNKGLQYAIKPDSVKTTEATPLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WW22</accession>
    <name>A0A6G0WW22_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_010980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000140">
        <property type="protein sequence ID" value="KAF0731674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WW22"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011926"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0731674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="215" mass="23852" checksum="214EE83C7D481404" modified="2020-08-12" version="1">MDRLVVQANALTLKQIAFHVANILFAVIACCIMWLTVAVCIVLSPVLLSMRSLTHWLCQIIRRVAQVDIHLYNSITPQGEHIFVSLTDAHELLATVLYFACIKPLVALATSVVAVGLILVSFGLMLLSIFPEALVDPHHRTAMPPAPTPLNFLLGSFFLYLSVFMIHWTARRASFATRYLCCDGLEIYRYVYGIPIPMSNQLSSRSMGFGTGVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WWH1</accession>
    <name>A0A6G0WWH1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Choloylglycine hydrolase/NAAA C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_010854</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C59 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000138">
        <property type="protein sequence ID" value="KAF0731901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WWH1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004809"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.60.10">
        <property type="entry name" value="Penicillin V Acylase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029132">
        <property type="entry name" value="CBAH/NAAA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052193">
        <property type="entry name" value="Peptidase_C59"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35527">
        <property type="entry name" value="CHOLOYLGLYCINE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35527:SF2">
        <property type="entry name" value="HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02275">
        <property type="entry name" value="CBAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026221154" description="Choloylglycine hydrolase/NAAA C-terminal domain-containing protein" evidence="4">
        <location>
            <begin position="17"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="394"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Choloylglycine hydrolase/NAAA C-terminal" evidence="5">
        <location>
            <begin position="17"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0731901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="428" mass="46716" checksum="7EDBDB579C47DD24" modified="2020-08-12" version="1">MRASWFFLAGLTVVQGCSDFLLNATSQVVSARTMDFFVDLRTVVEIVPRDTLVQESIVKGCPDCADYAWRTKYGFVALNSFGYNVAADGLNEKGLSAATLFLPGSQYPTPDATDAKTRPMVTSLVTYILGNYANVEEVKAGLLHDIQVVEGDPGVQVIADQQAAVHEDSYPLHFPVHDAAGKSIVVEFLNGTVNVYDNPAGVLTNEPPFLEQLALVAAHDKAHGTLDKTFLGGYTPVERFQRLTFLNHHTDAKFIANTTYSTATPDQAAISQAVHLISTVRIPTAYVKDGEATEYTLVRDHQNRRLFFQSNENQVLRRVDLDKIDFKNSSNRRAINVTYGDWSVDVTDVLLHSTASTIDIPSRSTIERLIHANSQPAAAITGTVAASELHHASFWMGLGVGVGGSAIVAAFVAARVYGRKTHDYVRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WWH4</accession>
    <name>A0A6G0WWH4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Beta-adaptin appendage C-terminal subdomain domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_011119</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000140">
        <property type="protein sequence ID" value="KAF0731821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WWH4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010542"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026193736" description="Beta-adaptin appendage C-terminal subdomain domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0731821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="692" mass="77120" checksum="04788C3FDDE66BF1" modified="2020-08-12" version="1">MGRRWVQCVGFGLFLVAFIVQAAQDTHIFAAQVKKTELRVKDQRNNSAQVAASLANDTIGVVAIQSASPVHSTNPVKEAPATAKPHDVLWCTDVGLGFELDFVSAYTDVRGFAHYFNDRMKTELQDRYSVYFRDVSPSETAHDKAFIVFTICEPRDDTAISAPWLMAVQAALRRVALHAKALQVSGDQSSKLTELSAYVVKKGQHPANLEVTPIESSINLVPPDSNGLPQLNVSFRVKNAGQVPLRIFQVVCHNIDGFRDVVLPLATRFVLGSGVETTLSLHGYVVQTENDTRTSSAMQVHIVQSSGEFREIEVDASIQKPPIQTTVVEETQEPEDDDLGFVKVITDGDEWSMPLEKEKHLPKDEFKPNLDIPKENPWPKNEFKYSQDTPTENPLPKNFEERVMQTAPLRMKEEDNIHPISTFPASSWKVLLLVGVVGYTSFFVYSKVKNRSIAWSKLQTKRRATREDRVPTFDDDYDDDDNDENSKECEMMLRRPMSPPAQVEKPDPIQLNHPWGPPKAGRLQPQPMKPVIQSPKKADPAATPPATRAPPPAQVPPRPPYQLQLDPTMRLHPKRFESLWEECIELKSWKRSAVTDEGRGLPGSGVIIAVFESQGVQCMASGSLQLVDKYLLYTYEVALGQYLFVELVVNTVSMQVSTSVRGHRDVPADVVDALATLSDALLTAMLTTIQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WWT8</accession>
    <name>A0A6G0WWT8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">L-type lectin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_010941</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000138">
        <property type="protein sequence ID" value="KAF0731993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WWT8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009314"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005537">
        <property type="term" value="F:D-mannose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07308">
        <property type="entry name" value="lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051136">
        <property type="entry name" value="Intracellular_Lectin-GPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005052">
        <property type="entry name" value="Lectin_leg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223:SF28">
        <property type="entry name" value="LECTIN, MANNOSE BINDING 1 LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223">
        <property type="entry name" value="VESICULAR MANNOSE-BINDING LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03388">
        <property type="entry name" value="Lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51328">
        <property type="entry name" value="L_LECTIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="L-type lectin-like" evidence="7">
        <location>
            <begin position="34"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0731993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="425" mass="47709" checksum="1B3AFB4169928A41" modified="2020-08-12" version="1">MERMPQLVLPKAERATMMKVLGAVALLATNIVFGEKLEQHSFGGPFKLIDSSGTRIINSTWSHGGSTEVLKSFIRLTPDRQSKRGYVWNNAPLERDTFSAVLQFRISGQGKKWFGDGIGLWLTNKRSHVQGENHGFTADFKGVGIILDTFVNHDHKGGHKDVTVQVNDGTKTLEVLQEETKIGCDAAFRYHEESAKFDPVFSSSRLRLVIVGNTLKLEVDEEATAVWKPCYEGTLPFSFDWLRDATVGITGSTGGLADNHDVLSFYGFSESDDIQMQLTDSEVYWNNYSKEHHDVLKSEHCDNSCKLIILEKALDNAKVDIEHQVVALKERTTKNIQKVKTREVEIHEKLLDLNARIENYMMNTVDSRIDSIANALQNEAHAELSNKVAVASGWKTPFALVSIGLLGGAFFLYRKYSELRKSHLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WWU1</accession>
    <name>A0A6G0WWU1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_010916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000138">
        <property type="protein sequence ID" value="KAF0731965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WWU1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009338"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0731965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="172" mass="19421" checksum="B68E4EBB25860E56" modified="2020-08-12" version="1">MSSSSVKKTTAWIVRAGVEAVLLLIFIVPQYFVPDENVEVFRLACSTVVTAAACIVSWNVGVTALVHCVLHVFARSFQSSNVYINGVVLVARILSFERLVSHVIFPRISYEARLQENKRKLEKFFSVHDKARVSEAEALLHEYMGNEQLLFVKLRRAYLARQPPTRVVLKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WXZ5</accession>
    <name>A0A6G0WXZ5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_010517</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000134">
        <property type="protein sequence ID" value="KAF0732408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WXZ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010747"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000180">
        <property type="entry name" value="serine/threonine-protein kinase STY46-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF611">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="27"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="625"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="330"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="652"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0732408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="884" mass="99376" checksum="44ED51145F025D84" modified="2020-08-12" version="1">MKTLARMFQPKRKVTETTAPPLFRLTFYVLFSLLFFLFLVLHLLGSILMLLWALVLLTQSTLTSHDHLQPYFVTYRKSCLLLYKIDTFILCWYDPTLARELHVPRDESDVSTVWHSLVYFYIWRGLVNASIALLPAALWTIAGVFFVHFFNYAPIMDDPFVHYFYDSRWFLLLNGGAYVSFGVVVGNALIRWCLDWSTFANSLLFPIIDYNIARNRYESVALLSMSRQSSQSMIARTMPFDQTVDTQITSPVVATVLKLAHRNDMAKAQASLTLSLAGQMFSLAAASPSIDPAILQWLNETINPLLVVEWDADDFQRELHRLHRDVDRLLQRQPPSLPHTGSGTSLIDSGFGSTGRSGRLGISSTGPAVVIDHGDDDESTAVSQSESRHKLQFSHQTNTDARGWGPVSHQGYDPLRHYHTFSPRASERTYGVLSPRVDTQTNTIFRSIEDKMDGTHVDPVDPVFFTAYAPPTISIGTAFYYDIWAFLAHQRDDVHDAAKSANAFARKLSRDVLMPIRRGAVAHLQLYLPPGFLVLDDPVKTLEWTGNELKSVQFHIECTPDAPAGGQSMVQVKIVVGAKVMVLSSYLFISPRNHQPQDNDVEMVPLTCELERLEETYHEIPYHELELQDAVGRGHFGEAFRANYRGRQVVVKTLRPDTFGESTDQIVQEFRHEAAVLNMFGHHPNIVPFVGASTDPSSTLTLVTEYLPHGSLRDAFPSKLSLTEKEVILYDAAAGLVNIHEGGFIHRDIAARNVLVDDELRGKICDFGLCRRVNASVGGGHFQEGQFPLKYMAPESLQPPYAFSYRSDAYMFGVLMWETFSEASPFASMSAPEAAALVLEGHRLDHTSVPDKYQDLLAACFEQDPMKRPALVSIMRAFEPIDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WY87</accession>
    <name>A0A6G0WY87_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_010276</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000130">
        <property type="protein sequence ID" value="KAF0732567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WY87"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020806"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17364">
        <property type="entry name" value="MFS_PhT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="465"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="27"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0732567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="516" mass="56005" checksum="A44A35D7BD0B4DAF" modified="2020-08-12" version="1">MAVGQGQRSVAFKDLDTAKFGAAHIRAMLVAGSGFFVDSYDNFVIGLIVPMIAWEYYGKSGLPSSRADGWVKAASSWGNMVGQVSFAILGDILGRKKVYGIELMILICGALLCAFAVWPVNGNPDNVLIMLAVWRFILGVGIGGDYPVSAVITSEFASSDRRGQFIAAVFAMQGFGIICAATLAIIMLAAMQSPIVENTKNIGYVWRFLAGFGAVPALAAVYWRLRIPETPRFTVNVLGDQEAAVRNANQFLQGTAHDNNISVPKPNTTKSFSEAFRTHFSQWANLKVLIGCAACWFFLDIGYYGTNLNTPAILSIIGYGSPTSKGNQKIYDDLWNRAVGTAIINMCGTVPGYWFTVFLVEPWGRKPIQYLGFGMLTILFLILAIWLDDFKAHYTTLFVVLYSFAQLFFNFGPNSTTFIIPAEVFPTAVRSTGHGISAASGKAGAILAAQCFAVIAKGSFGFQGVLYIFSACCFLGLLFSFWVPETKGLTLEELSGDSTEKIVEDYEESKTPAAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WYU4</accession>
    <name>A0A6G0WYU4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">subtilisin</fullName>
            <ecNumber evidence="8">3.4.21.62</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ae201684_010373</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Hydrolysis of proteins with broad specificity for peptide bonds, and a preference for a large uncharged residue in P1. Hydrolyzes peptide amides.</text>
            <dbReference type="EC" id="3.4.21.62"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.62" evidence="8"/>
    <dbReference type="EMBL" id="VJMJ01000130">
        <property type="protein sequence ID" value="KAF0732666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WYU4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020154"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01100">
        <property type="entry name" value="APPLE_Factor_XI_like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000177">
        <property type="entry name" value="Apple"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF67">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14295">
        <property type="entry name" value="PAN_4"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 10" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026147461" description="subtilisin" evidence="12">
        <location>
            <begin position="18"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="13">
        <location>
            <begin position="161"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="14">
        <location>
            <begin position="1037"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="14">
        <location>
            <begin position="1112"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="14">
        <location>
            <begin position="1179"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="479"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="668"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="486"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="499"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9 10">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9 10">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9 10">
        <location>
            <position position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF0732666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1238" mass="125920" checksum="335BD107269C6851" modified="2020-08-12" version="1">MKVRVALAFLTAAVVQAKVSFNVLRNLEASKTTGAVVYLNSDVKVESIVKQERSDPRTAVFEALSTEVETFKTTVKTLIGDFDKKLEHASWIGKALFLNDLTADEVTALAKNPKVKKITSRFSIVLDEPIKPENAIQDLTDQPQWGVQTVGAPSIWKYYTGKGVVVGSIDTGAAYEHIAIKDNWRSYKGWFNPYNGTAFEKPFDSAQHGTHTIGTSVGKFGIGVAPDAQWISCLGLYGKSGTDAALAQCAEFMVCPTRLDGTHPECKQGADVINNSWGGQGDYDPFYEEAISAWRAVGITPIFSNGNAGPACKTTGFPGGYTRVISVGAIGGYNNETNQLAYFSSKGPVTSYDENNKTVTLIKPDIAAPGFWTVSANALNLAGYIRLAGTSMAAPHVTGVVALLKSAQSDLTYDEIYGYLTKTTDRDLLPEPTQWTTPSGTVIGPGAPNCGGVDDSKFPNNRYGYGRVNVATILRDGKLHDTQSPQPTPVATPAPTPAATPATTAAPTPAGTPATTVAPTPAATPATTVAPTPAATPATTAAPTPAATPAATPAATPAATPAATPATTVGAATPAATPVTTPCPTDITPKPTSTPAATPATTVAATPAATPATTAAPTPAATPASTPCPTDITPKPTGTPAATPATTVAATPAATPATTPCPTDITPKPTGTPAATPATTVAATPAATPATTPCPTDITPKPTGTPAATPAATPAGTPATTPCPTDITPKPTGTPAATPAGTPATTPCPTDITPKPTGTPAATPAGTPATTPCPTDITPKPTGTPAATPAGTPATTPCPTDITPKPTGTPAATPAGTPATTPCPTDITPKPTGTPATTPCPTDITPKPTGTPAATPAGTPATTPCPTDITPKPTGTPAATPAGTPATTPCPTDITPKPTGTPAATPAGTPATTPCPTDITPKPSSTPAATPATTPCPTDVTPKPTSTSAPTTTPAQTPASTPATTPITPEPTPATTTAKPTTTAKPTTTPKTTTAKPTTTSKTTTAKPTTTTKPTTTKTPKPTTTKASQCGKVVEGTDYFGYDLKSTSRANHEDCCDDCAKTPGCVVYVWTPWNDGTCFLKWKVGKASPYWGAKSAQKPSKSQTCSAAQSNTDYFGNDIAEITADKDDCCDLCFQRDDCVGYSHYNGVCNLKGSLSSPTYKYGVTSGVRPSCGKAEANTDYFGNDIAEITADKDDCCDLCLSRDDCVGYSHYNGVCNLKGSLSSPTKKDGVTSGVRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WZ27</accession>
    <name>A0A6G0WZ27_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_010176</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000128">
        <property type="protein sequence ID" value="KAF0732848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WZ27"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018696"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="391"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="497"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="593"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="631"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="631"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0732848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="655" mass="74588" checksum="DAB3E333CF17DA4B" modified="2020-08-12" version="1">MSDDDCCSFANYSFETNASVTEFSVNALINAGLNQKVSVPTQFAFICIVTVFVLCFEFILESIEHVIARHPTYWRLLNKMYRELLVGGLTAFVSKRLDQWNVMDETEQNKLNIGDEMVLYFALSIAIQSALIFTMLRKRNQRADKLSALNSRDLLEYMTTDKDAKPRSLSSQSIMKNKILQNFFLTTYKLPDMFSFPKYLRSIQDSEIFSLFDVEIIEWLLLVATYSVFFRIADDLEIRLTIDENASDEAIEAGIEFGIAKGMLENRLKILLGFILLLSATIWALDWFLRRRVRDIVTYAANGQESYLEALREVADQEDARLAKPMTNDEAISTMMELADSLSDVKDHSSIWDLIKSAARRLVGRAHVKTQTLEAMTNLNLRFFSRKAVHVFAKLLLAFNAMYFALVWATFNASLVPVITSQEATMYPVWLAGLMAILIVNMVYFAPRLVRQLALVNATVRVNPNELKTVIEHFADVLEMQTEMAEAINEYCDANDKDAKELEQDMVALDPQGTGYIEGEDLRNIIIRYGFKFSANKFQTFVRLQFKTRGTKVPYADFCRILFGLTDQLKAHHGALSEFMTGRNLNSQYLHSLRRGGTSDSMHSNNSSNSSRRTNRALLYKLAGFQRGNTNENADSASQVYHQVQTPNKTDDALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WZ41</accession>
    <name>A0A6G0WZ41_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_010106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000128">
        <property type="protein sequence ID" value="KAF0732774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WZ41"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003558"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0732774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="17019" checksum="57C46BF6F09176E0" modified="2020-08-12" version="1">MKQDLLRNYIKRVAKDDKEIGQLSEPALQSLRMATEFFVDEIGQAIDEYVRTSKEPVTGNTLKELLVASKSMTFACMKPLLESTTISSSREKPLKRKAVSGAALARQTPHSKKLKKEREIMDQLPSVSEPPPPPPPIVHPIIEEDDDYDASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WZL2</accession>
    <name>A0A6G0WZL2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_010062</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000127">
        <property type="protein sequence ID" value="KAF0732954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WZL2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021724"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051510">
        <property type="entry name" value="SKI8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44090:SF1">
        <property type="entry name" value="SUPERKILLER COMPLEX PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44090">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="9"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="138"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="180"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="222"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="264"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0732954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="302" mass="32525" checksum="2C0A7224CE1A3EF8" modified="2020-08-12" version="1">MYRASSKVTSAHNDGVWSTFWTSRDQILSGSVDEVVKSWDASSTDESLSVMKQYPGHVLGTISVVATKDGRRAATSSLDCQVRILNLETGGIEKTIDTGAGEVWQITYSPDDQFIASGSQQGKVNLINVEQEKVVRSFAANGKFIMSVAYSPDGKLLACGGFDGVVAIFAVETGDEVQKYEDRTKPVRSIAFSPDGSFLLAASDDMHVKIYDITQKSMVASVSGHISWILSVACSPDGKHFATGGGDRKVKIWDLAAKNCLYTFECHTDQVWSVAYNSTGSRLVSGGDDALLQVYEIASSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X065</accession>
    <name>A0A6G0X065_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_009821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000124">
        <property type="protein sequence ID" value="KAF0733257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X065"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017754"/>
    <dbReference type="OrthoDB" id="10411819at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0733257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="73" mass="8544" checksum="737EB7F997FA76DE" modified="2020-08-12" version="1">MDKVQMEIIALQEELEKKQTELNSLEEDLVRLHLRVLRLKAPLAYLQCRLANLKDDEEATLITTEKSPNRILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X0E1</accession>
    <name>A0A6G0X0E1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_009808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000124">
        <property type="protein sequence ID" value="KAF0733244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X0E1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017741"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0733244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="368" mass="37883" checksum="FA85B8648706FD9D" modified="2020-08-12" version="1">MATVTPTEPELLKVVKEVLGQNPHFGAKRILGAVKKSNDAWLVGEKRIVKMLKKHGLAHHHHNGDHHHSDNQSSDEEHHNDNNSSPAISEKKAVVEETPEVNEEPAKVAEVPKPAPAVETPAPAAVEEAKIEAVVQASSEPVVEAASEIKAESVSVPVADVAVETKAVEKTEAVAEVAKPVVEAAPAAETPPVVKTAPVVESAPVVETAPVVEATPVVEAAPIAEVTPAVEPTVPSTEAEKAVTGESSVAAVEVVEVVPPSPEEPVPAAVVATETVVETTSTPAEVKLAAETLVASVTSEAVASVTAKSSEDKTEAVVQETKAEVVAAEAEFKAEIKAEAATTEKKTLASPALDPAAESAAGCKCAIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X0F7</accession>
    <name>A0A6G0X0F7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Beta-lactamase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_009817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000124">
        <property type="protein sequence ID" value="KAF0733253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X0F7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017750"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050491">
        <property type="entry name" value="AmpC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825:SF9">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825">
        <property type="entry name" value="D-ALANYL-D-ALANINE-CARBOXYPEPTIDASE/ENDOPEPTIDASE AMPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="1">
        <location>
            <begin position="56"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-related" evidence="1">
        <location>
            <begin position="569"/>
            <end position="918"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0733253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1075" mass="117081" checksum="FE9DFE6F48DF3135" modified="2020-08-12" version="1">MRALVLVGLIFAIVAFWAITLTSINSKDSSAKTYETSHREANKIKSIDKKAAAIAFVEKQLQDKPIPGLILSVVYKNQTVIARGFGTKQAGNPNTPVTASSLFQIGSYTKTLVAVAIAKLVDDGLVQWNDPVKQHLPWFRLQDKYAEKYTTLADLLAMNSVFGAFQGDVVWEMSTYPTERELVEHLVFFNTTRRPLRAGYAYSNLNFEVLGQVIEAVTTQTWFNYLQRSILDPLGMNETFGRAKDATNVDDLSYGHLTCGSTILGPYNPLKATQIALGAQDPFLAAGSIFMSANDLSKFALFLLNKGHGVLKSPSLIDDLTTGHVVLPDFVMAALDDGDILGYSFDPDGNTVAAGYGIDVVGKVMFGLDYFSKSGDTIAFKQRNGFVPSQHVGVSLAINAQSKDLPGSAAYFLLDRMRSYLVGLFLDVPPEQLDAMWKQGIAHSETLEPTKPTCDPRIFGNEPWKVDISPALQDKLVGTYVAKDSPLSYGKIQIFKQAKASMLQYGAYTRPLYATNATTTLLWSLDFGAELLPLQIHPDNADNPVVSFSGIDLVRQDDVAEKKAMALAFVEKQLEKSSTPGLLLSIVYKNKTIIARGFGAKQVGNPQTPVTSSSLFQIGSYTKTFVALAIGKLVDDRRLNWNDPVKQHLPWFTLQDKYAEKFTTLQDLLAMNSVFGLDQGDQVSGMGVYPAERELVQAFGRLNTTRPLRAGYAYSNLNFNVLGQVLEAVTNQTWFGYIKAVLLDPLGMNETFARPRDAANAAADLSAGHLSCGGKVLGPFDQDNTSIITTVGGMQGLDSSGSIVSSANDLSKLSLFLLSKGHGVYKSPAIIDAITTGHTVLNTLLFVDMDRADALGYTFKPDGSIVAAGFAMDVVGNVMYGHDFYTKNGDMIAFRQRNGFVPSEGLGVVLASNVQPTDGAKSPSNFLLDRIRAYLLGIFLDVPTDHLDALWNQGVADAPDAETPFEACDGHYFKGEPWETPGVVIPSEVQDALVGAYVSTDSPDYYGKVTIAKQENDRLVLTWGIYSKPLVATKDPSTFIWALDYGGNTIAVNVTGVNSSRPKLALYNLDFIRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X1T8</accession>
    <name>A0A6G0X1T8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Vacuolar protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_009410</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta-catenin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000119">
        <property type="protein sequence ID" value="KAF0733850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X1T8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009549"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071562">
        <property type="term" value="P:nucleus-vacuole junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045156">
        <property type="entry name" value="Vac8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47249">
        <property type="entry name" value="VACUOLAR PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47249:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="106"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="917"/>
            <end position="937"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0733850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="937" mass="103463" checksum="9FD303858E652EF4" modified="2020-08-12" version="1">MSHRLSQAARHTQELLQDLERDKELDVIRIYLARFELFPRARDPKTAPIRSEELRDLVKFWKLHRQRNFWKNHTTKEDLVRMLYKHITTKVMPNEKTLLMDTPHPTIPLSPARPPSGANVDSPSKIRRTSRMNPPLNSPTPRGSTTDAFDPYGGDLFHQRGDYDDGMLYVSRLAPREAGLAIEDFALDLTDPASKDPSVNMHANMHDEDASRREKRLLAECACSLYQLTLEPGHEADIVREGCIPAIVRMCTFDDVEVKKYCSATIVNVSVDASLTARLIDEGVLGGLMELAKVQQEDIRRNAAIGICRISYDRLGQAKLIQEGSVPALISMLNNTDFETKEACVKTLINIASFSGAVVSESVTHTVTRIAAKRNRAYDRFIVETICDLSLLSGPRAKASDDGILEPIYDTNRATTDLDLKRMIAIALSNFSGLEVNHQHMANPRILHALDSLLSVDDVSIREMAATAIANLACSAEFIDRLVAFPDAEASEPFNMALRLVQAGYNASQVVQENVSAALLNIALRGENHRVQLTQHGVALLLIHFFETSNWTTKLHAVVLLCTLMANDLARAQLVQHDVHVSVVMLAADATTRDLCAVALFNLSCFADMAPYLLAPQTLATVVELLTPPSKDEKDPTLTVAQAFALDCLYNLSFLTTSSEILIHANCIAALGAVFRKPSKNMDANLRAAATICNMAFCPTLDLLQRMLDEDVLKLVRRLGSNSANHRELTLCCSTALCNLAVPALQTSGSTLVNMLIELSHTPHAEIAFVCAISFSKLASAASGMREMLAKVADLPPTLTVMMRSGIEDVQIHCAAALCGLACERGVKGSRHMWKEGTITDFIVNSLLRINSDSTKEVCARVLFNLLTHEDCRSFMIKDGVLYALVKLARLDSVEIRTLCVTALYNLSTDAAMRIQPRRQPPTARGLSDQRGFAWRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X1V1</accession>
    <name>A0A6G0X1V1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_009369</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000119">
        <property type="protein sequence ID" value="KAF0733801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X1V1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003498"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="493"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="526"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0733801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="567" mass="62771" checksum="51EDD82CAB5175F6" modified="2020-08-12" version="1">MSSVLSEEAILLPKGSVGQRRPAVWAILIMNIANWFAYYGITQAFKNFMEDKLHYSKISACTVRSTWTAFSSIVPLFGAYIGDERWGRYLALEFFTAWFVGGAGLVALSAHPTILTQYLPLANVVFLVSLFAGIAVGVGVFHPNIVSFGADQASALEASSKELFFSQYYLTANLGMTIAYTCLAYLSVNGMGQWIPLDYGYFATFLIAGAILVVALVIFSAYSSTYVKANPRHGAFTEVFSSMVESMKDCPELGFIVSGFGMFALSFHLNVVAILLPPTNTATTVITWIAGICVLLGMGSWIVHTLDVSFIDSHETLPHSVRSDLKQLLRMLLLACFHVMWQCVLDQMDVNFQSIAQQSDLRLASGRLAPGARSKTPTESKMVPCWPFLIPSGFYSSPPSWTTCYILAAFTMLWTAWVETWRRESGEIDLADGLGPLLDLGTHKPMNNLSWLYIAVSYLLSSLCECLINIPSYEMFYTYVPLHWKSSSQAMRSFMLALGANVASIFTLVFARDIPDDLNQGHLENMYYCMAVVAAINAAGFLYVIKTTNFVQAIEESFHNSKLQEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X2E9</accession>
    <name>A0A6G0X2E9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_009184</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000118">
        <property type="protein sequence ID" value="KAF0734011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X2E9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017088"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024395">
        <property type="entry name" value="CLASP_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF85">
        <property type="entry name" value="TUBULIN-FOLDING COFACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12348">
        <property type="entry name" value="CLASP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="4">
        <location>
            <begin position="289"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="350"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="359"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0734011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="465" mass="51431" checksum="84E32A784868D252" modified="2020-08-12" version="1">MSNFATAVADAMESIKKNTDDWQKRMQALQEIQKQFKSLENSTTTVPVDAWRALKPLKDVIQDLRSQIVKEVCTTLAVMSSVTRDAMAPLARELLPVLVEVRGGGNKVCGAYCGECVEVLVTNIVTKGPTVRYFVDGVVESKNKVIRACCITALTLVLVNWSTVLDKSDVQQIEVGLKSALTDASATCRDLSLKFFQRFQQKFSKRAPALVASMDPKVQRRLTSLPLLDESATSNDLPPPLTHSNSNSIDENYGQEDKQVILTDSDGIDIGDRVCISEKELFGTVQYIGDVAGFAGPWVGIQLDVAHGKNDGSIKGHYYFRCKPQHGVFVRPSQIFLTKKRNVSFDFADDMNGPISEHDGDEEDGVNEAEAEDDTLQEAQPEDPPLKKLLDSVLDAQRGYLDFMFLNLNVEMDHLDVFQKSAEIASSADAVAYCDQVRNICQEKIDATSAFMEKIIEAQQLAMET</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X4T7</accession>
    <name>A0A6G0X4T7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_008431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000102">
        <property type="protein sequence ID" value="KAF0734954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X4T7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000166"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35213:SF3">
        <property type="entry name" value="MYB-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35213">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0734954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="195" mass="21224" checksum="2D411441C2E886A2" modified="2020-08-12" version="1">MEPTSTSVSSNNPKLRIDFLMSPSPSLNKPATAGRKVKVTPTPTKQARRAGGWTVAELEYTFRLSADFKDGLLPDAPPGILLRQYLSLKLNCSPMRLSKKFDKSSGILGMHRYDPTASVLAGLTPEMRRARKKELKQLEEAFRKSAADDTEVVDVDAAATAAGRKRRKVNPLPSGVSSPRAPSSLDLLVSMACRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X6J1</accession>
    <name>A0A6G0X6J1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_008010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000095">
        <property type="protein sequence ID" value="KAF0735530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X6J1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021196"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0735530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="288" mass="33160" checksum="548957F6D0CC42B9" modified="2020-08-12" version="1">MNQLRIAEDFDKEWLTKIMTCSELPDLSHLVEKVSGPLRILIPIANPAGLFAHLNSLESPPTQSIHQVFEENAAKHCPEVMKRIQKILFDVAPVATTENSFIGFWDNIILQTLLVIFQRTGCSWDRNSSKETSTLSDRPDFIFRLLHVCVFRGEEERSGEDQEVPRNKLIDKLVWTYGEAPYLFGYSVCGFELRLHAILPPCKDNEQKEQGRRPCKIPRMPTCSTIPLGFFHLDTVCGCLDLFRSLVNISPYLLRIAKLCPRRNRPEYTVCVRVLTRNELIWKKKTTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X7K1</accession>
    <name>A0A6G0X7K1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Leishmanolysin-like peptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_007581</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000090">
        <property type="protein sequence ID" value="KAF0735988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X7K1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001123"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.132.10:FF:000001">
        <property type="entry name" value="leishmanolysin-like peptidase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.132.10">
        <property type="entry name" value="Leishmanolysin , domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.55.10">
        <property type="entry name" value="Leishmanolysin domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001577">
        <property type="entry name" value="Peptidase_M8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10942">
        <property type="entry name" value="LEISHMANOLYSIN-LIKE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10942:SF0">
        <property type="entry name" value="LEISHMANOLYSIN-LIKE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01457">
        <property type="entry name" value="Peptidase_M8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026328788" description="Leishmanolysin-like peptidase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="606"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601577-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601577-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0735988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="731" mass="77387" checksum="5232C1940AB42BC6" modified="2020-08-12" version="1">MQATTLIVALAALVRAVATAELMHDCGHNHIVSDIPRSAPQEYDDSHPQLRMLMAEVDASGAATSVDSTAVYQKLRITPFYDDASVNALSSTLSSYLKSKLVPDAIDFWRSTLSVVPLSGPWYAQPSCATTWATTPVVCKTVSSAPKCYEQTIPASHLASMKYCSTCPRTGCVGGVCNTTAAGSGVPDTDYMLYVRAVRTTMCNSNVLAYATVCQIDQFDRPTMGMINFCPQRLSADAADYKAQIGVALHEIGHALGFSSQMYARMRYPDGSPRTPRDASGDPPTQTSYTCPNGYVANAIQMPSDSTVQFFTERGHSVAKLVTSNVLAFVRSYFNCSTLNGAEIEDQESGCLGSHWEERLFESELMSPLQSFSMAVSGLTLAYFQDSGWYQVNLTSAQRMFWGANRGCAFATDACIQGTPASPIPVPDDHFCVNASTDGCYADLTSIGFCSLQTWPSTMIPSYDRYFADPSIGGNSYPDYCPLLRGSKSGDCSVPSNLDTPTGTSINLLGETYGPSSFCTKSSLLTYSNDGWSFPSRTTGCYAMMCLADGTINVTVVGAAAPVQCTAKGQVKTVVGFRGALTCPDPAIVCAGLPCMPNCSPRTSDSETSITVPAPPPTSTLNSSVAATPTITISLTTPPPTPGNATNASSTISPTITYPPTPPPVATHATFPATTRPPVATLAPATTLVVNKTTLTTIPPNETTTSAPKQTKSAAGKPILITTAILCLTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X8L7</accession>
    <name>A0A6G0X8L7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_007410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X8L7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021250"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006461">
        <property type="entry name" value="PLAC_motif_containing"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01571">
        <property type="entry name" value="A_thal_Cys_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15907">
        <property type="entry name" value="DUF614 FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04749">
        <property type="entry name" value="PLAC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0736391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="199" mass="21380" checksum="94782C53456C0DBF" modified="2020-08-12" version="1">MGIERITADRGSLANSFAVNTALGSDIKLAPYQDTDGTIITDDIATLSAVHHQTDANGIIVGEWCTGLFSYHTVYMWIISTFVPCVSVGQIAHRVGLAQYTTCVLLVGLFYLATVGCSLFEHTTLNVIAIVCSLIFVSVVTALRVRVRQLFQIPGFVAMDLCTVMWCGCCAIAQMSAHVSSAKPGVCSLVPRDVLPGYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X976</accession>
    <name>A0A6G0X976_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_007094</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000088">
        <property type="protein sequence ID" value="KAF0736644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X976"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018314"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047536">
        <property type="term" value="F:2-aminoadipate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047315">
        <property type="term" value="F:kynurenine-glyoxylate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016212">
        <property type="term" value="F:kynurenine-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901605">
        <property type="term" value="P:alpha-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000071">
        <property type="entry name" value="Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000166">
        <property type="entry name" value="Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF19">
        <property type="entry name" value="KYNURENINE_ALPHA-AMINOADIPATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="79"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0736644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="424" mass="47050" checksum="5AB3FB57C4DED17C" modified="2020-08-12" version="1">MQAWRLKTIRSFSAISYDAFLTPRSLRRQPSPIRSLQPLVSLPGMISLGGGMPNPSTFPFESMSIKLKSGATMDIQGTALQQALQYSPTPGLPDLAQIITTRMEKEHQPPQLDSPRILSIATGSQDALYKAFEMLIDEDESLLVESPTYSGTLAHLHAVNCKLISVQTDGNGLVPDHLASILDNWDHSKKKPKVLYTIPTGGNPTGVSLSFERKKQVYAIAAKHNLLILEDDPYYYLSLDGNRQKSLLHLDVDGRVLRFDSYSKILSSGLRLGTVYGPKELVERMNLHTQSANLHSSGLSQAVVLELFKQWGEKGWNDHVSSVCEFYRRQRDAFLVALEKHLTGLATWEVPDAGMFVWIKLLGVEDSKSLIEQKAVASKVLLVPGQVFLPDNQKTSYVRAAYSTATPEQMDTALSRLASLLQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XA85</accession>
    <name>A0A6G0XA85_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_007029</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000087">
        <property type="protein sequence ID" value="KAF0736874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XA85"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017812"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026226595" evidence="2">
        <location>
            <begin position="18"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0736874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="151" mass="17017" checksum="ED48C41402972AC1" modified="2020-08-12" version="1">MWAILLGLHLFSFFVNPHLPEGSSSPYVYVMLGLAATAIVLKAYSMWTQPCCWKNNVLPMETRVALCFRLFGYVWSNDVRRWRNDAVSKLSTVGFTTILATIAATVFISPYSPLLAFVILVLGVTTATILDELRECVDLMKKIWPLSHKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XBD7</accession>
    <name>A0A6G0XBD7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Myosin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_006502</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003151"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003152"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003154"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00124">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.530">
        <property type="entry name" value="MyTH4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009836">
        <property type="entry name" value="GRDP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000857">
        <property type="entry name" value="MyTH4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038185">
        <property type="entry name" value="MyTH4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07173">
        <property type="entry name" value="GRDP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00784">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00139">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51016">
        <property type="entry name" value="MYTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0518">Myosin</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="9">
        <location>
            <begin position="186"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="domain" description="MyTH4" evidence="8">
        <location>
            <begin position="1491"/>
            <end position="1645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="61"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="6">
        <location>
            <begin position="693"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="267"/>
            <end position="274"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0737333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2408" mass="270577" checksum="418123F684485463" modified="2020-08-12" version="1">MSSYYIHDVNGSDGPFSLDDIQQAFAKGRVTDTTMLSVDDDPAVQTLADRTSLRLKMPQFAQAKWTSPVKDQKRSKSLVLSAPKPPPRLKAKPYQRETTPNATNETIEKEDSPERQSHENKEHDDRDSESNQELAWWKNNFDGYILVQVIERRSPTVRILQDGLDTTRDVPESDIQILTSYPPLAATISNLVRLDSTEEPAVLHCLRQRYLEDLVYTHVGNILVSMNPFRGIPAQESKTAPSPHEIAAKAYELATRTGAPQSMVISGESGSGKSEMTRSCLQYFATVTDRGINLEAMLLACSPILDAFGNAKTLHNVNSSRFGKLIKLHLNDRGKIDGCSVTSYLLEKSRLSSVAAPERNFHIFYQLCANMPDEEMTKFAYLGDQESTLHDKSSLASTIEALDAFHFAKTEVDFVLAYCRGILHLGNIQLDGDCRSTLTSQASVGYAATCFGCTVEELVTTLVTRRLRIRGELMEMPLEGAQAVANRDSLAKAIYSRIFDWILRRINETMQDVHGASRSYILLVDIFGFETFEKNGFEQLCINFANEKLQELFYSVVFDEAIARYRTEGLTVPAIDHSFDSTVLHVLESRPKGIFLLMDDEVAMPKATQHSLHSKITQAHGKSSSFVMEKTPLLFTLKHYAQSVTYDCDDFLTKNKDNTAEDIAEFCHQLTLLREFTTPRTEATIGATFRRQLRELLTVLRGTTTHFIRCIKPNRDQLPHYVDGPYVLNQLRHMGVLNALAMHRGGLFPYQESHESFFNSYHILCDGYDAKTSLMQRCQSLIQHFPNPDGFAVGTTSVFTSVEMHKWLDQTRATLVAAKVCCVQRWWRRQLWHATTLEMNEICKKLQEDSQKISSLESFMARAQQLMIRFPQCYKLTQLSTSCQAAEQQLHQLRQVDELWQRLSLPGRDIDSVEADLALCVKLNLLDDPRVLTFKEEHATLLQKQHVLLQLRDMLDSKVIDLPTLDQLLAGRHDFSKDLKNEIESARQAIATEDDDFTRLRAAIANSAVDIATLQCQFADWSCAQVDQELEKILHKPAWSSTLNSTVHLVTKLQHLRSTLRAVCRGTALVGCPDLRQLLNVEIGSDVDGTMAKLWQREVNLVRDVLDTYDRIHKLLSKAWLCKVPQEHVFIDLCDQMSTMATRLGIAFDPLVAMEAQTMLENIRMEKQFVNEVESIVAVRPDYAAKENLHIERLHDLAAIVPTPPLYDKTEIAADVCQFLSELRCAAKAMFDAKTLSAVETEWSRVESVLQQGYRKFEFVAGNKWFRIVAHGLELEQMLLHDVVKFKRNSARVGTHLEQALAAKFHPWLLEGLAQVDALGLDKDYTLRDTILRAKSVVEATKVLRHELRHAIHVVSPVLLQDALVKAKRLKLQSKLVRRATRLLEATDKILATFSQIQFDVDSDRLRKFARSVAKLMLQSPARTRAEWLLTLPREKYIQEQLKWAIQQSAAPDKVLDLTLALKDFVFDRSGSVFAVENFPRLRSPQAMQSCPTIPLTTPCTRLSSLDTKLALKASKFILTYLGVYQPSCLYPQRLALELMALGCQSRHVADEIYVQLAQQIRSDTISVGPPFRVTKAWELVWLCVATFPPSEVFWNYFEYFLRQQDRLDLVKLLHIPKPQFFLLPTLDTVFHTLHPSGVRLDGWALCRVPAAHRLARKWLVLENTKLYVFADNKFKSDARTSIDVAFVDEIQETNEEQPSIRLASRSKKSASWILHFDAKLDHMTWFHAMHSAKIAYWKTILPSSLPLLSWASNAHESDASSTQQPSEAPTLPKYVVDFDVRTKTGFLVKKPKFERRQFVLTGQTLEIHHEGNATHSFIAGDVRIELLSGYLYRLKGKPWQRLVLSIPSASRVDRFRQVLSLAAKTPHWTPPPSDVMTSLLQVATEIIESKCALPPSPNPHVRLYSPDRLHLAISTVTVGQVQAHLAEMFAMYEFQGKCTSMAQVYSRLVDLEAAYLANRSVNNFAHTVHRLHPVQYVKSKHRASYPPPVFKSAMEMFSKCPYADCQHDLPVEAMYKSHVKGETISCGQCQRKISPAAFRIAAFIKDAPQFHIKFNLNKTATSITVVMPPVPEDGSIKTLMEEQAPQANKWGVLDLRYQVYTKVYKHFNEPTLDLVLAMLRQLDFVNKICAHMEYWNNPTVIQASIIRYHKFMHLFKFGGRRYVQVPTSDIDLVWHTHQADDSNYRAFCGTHLFKVIDHDDTIKSESLERSFEETYRLWLNTFGDFYSSYLPSSSGETRTEDKIQVPSYDCRFVGVNEPFAVEALPYATAVIPDKLAVDNAKTPPPNNLTVFLTVIGSPVMDGRVRLKYSRQSYLMGQGHLGYVNFDSSQGDTKCGCVGNYGSGQATGTGGCAAAGCGGGGCGSGGGDGGGGDGGEGGGGGDGGSGGDGGGCGCGGGCGGGCGGGCGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XBJ2</accession>
    <name>A0A6G0XBJ2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SNRNP25 ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_006600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XBJ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015760"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040610">
        <property type="entry name" value="SNRNP25_ubiquitin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18036">
        <property type="entry name" value="Ubiquitin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SNRNP25 ubiquitin-like" evidence="1">
        <location>
            <begin position="64"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0737438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="156" mass="17615" checksum="B3361E5C7C30EEFC" modified="2020-08-12" version="1">MTVEDEVTTAKALVNQLLRSDIEQTRFCTSELEDATFRGLTTRTSLDAIKNLIEVATPATTVKFTLHLEDGSCVIVVVGVSATYSTLLKEIQCALKSTVKRSISWKYMWRHYGLECNGVLLEIPRHAKSPVLDFITEKHNVTDFHLRFVPRRSSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XBM6</accession>
    <name>A0A6G0XBM6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_006724</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XBM6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021208"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000008">
        <property type="entry name" value="Cathepsin D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026182443" description="Peptidase A1 domain-containing protein" evidence="8">
        <location>
            <begin position="20"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="411"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="446"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="510"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="551"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="582"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="621"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="9">
        <location>
            <begin position="63"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="259"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0737569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="659" mass="71528" checksum="959C04F62E805A31" modified="2020-08-12" version="1">MLLWLLVLAAGLLLPEASCEDAPLVRIPLYRRPKARQFTVNGTVALSATTSQVSLTNYAEVQFYGIIQVGTPAQTMSVTFDTGSSDLWVPGTSCKRCGGTRRFDTTASSTFKHGSSKKLTIGYGSGASRGVRARDTISVGGIVASNVAFGVIDYEDAGMQNIQSDGLMGLAFELLADISHPPPFVALVRQNPHLAPQFSFYFTPEPNADGSEVIFGGYNESRMVGSKWLAIDVLPQYGYWTYWRVQLHSLIIGDEWRVCDGNCVAFVDTGNSLIGVPSIVYEDLMQTIVDETSGCQCGIASDGLIACTKCSAAAFPDLRFGLGGHAFFTLSGADYTLCGGGTCWILLQSSALDNMWTLGDVFLKKYYSLFDVKAKQISLACPVGATHCGQEEDIVAMTFKVDLNGLPQQTALILATTGSSIIGCIFILATYLIYPALRIKQVSHIFAGLSVFNIVYNMFIWVGLLGQYGKSTCGVQLLGEQIAGVGIVWLSSQVRQPVGPKERHANPSTVLWLFWAATSICFAVFTGVAGFVPHSNMACWVDHTPTWSRVIMFYAPTVWIGSQVFIDLYLNSLDYQSRQRSVTLVSLFALAFGISPLVPALIGLIASFASVSQVLVDASEICFYSQGFLLAAAWAYNMTFQDDIKGQRLGNRETERLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XC01</accession>
    <name>A0A6G0XC01_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_006341</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000083">
        <property type="protein sequence ID" value="KAF0737676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XC01"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020413"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="152"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="477"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="493"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0737676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="520" mass="58457" checksum="9E2C34730CCEAA5C" modified="2020-08-12" version="1">MQLCSTIHACIPERFSEDHGNSPCEAHASRGRLPGRHHSTSVRSSCVLHYTPWEHWEDIHELIDLGRFYLCHWKVHGDINEMGLPPRAQMIAPTLSVRLTLRPRHGLSSERARLKRGSGEMQDFLWTEMETSILRMQTLETAALSLSWEKAFVLEGSVGQGTHSRVFRAKYKATGEDVAIKMIVKSAAKAAWPREIAVMKMLEPHPNVIELKGTYETSEYVCVVMEYAMGGELFQLLIRDGAYSEEVARRFMRDILAALVHLHKQNVVHGDLKPENLLVTSKHASKANVKLADFSMAAVLTSQRLVEKDSLTWAYCPPEVLQAPATATALDPKIDMWSVGVILYILLSGRHPFDPDGRCSKEIMIDWILQFQMVDLHAGWEDVSSEAKDVIRQLLCRDPAKRLTAEEALRHPWFTQTTVPTLPLQSSLRGDLNIYVRSMTSRFRTTVVVAIAARRFSSLHKKPEDIQRIQREMKLAEDSTLHTVDQAPPQGSKPPSSDSTFTEAVLDPASITVDGPPPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XEF0</accession>
    <name>A0A6G0XEF0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_005611</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000072">
        <property type="protein sequence ID" value="KAF0738560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XEF0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014594"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052365">
        <property type="entry name" value="THEM4/THEM5_acyl-CoA_thioest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12418">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE THEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12418:SF19">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE THEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026206879" description="Thioesterase domain-containing protein" evidence="5">
        <location>
            <begin position="25"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0738560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="26102" checksum="EEEFC0EDD52E1F03" modified="2020-08-12" version="1">MWWSFNHFLIIAHAVMASIRHVQGIVRRFATKATGTPFFSTPSKATHASFLEVPSKIEEIAANSNYVALTKDMIWNNPNFARPRSDVADDFFLPHIHEPGKYEAMQVYGHKDKTHAVAWVHFGRQLGGPKDFTHGGCIATVFDELFITTMIWTANRVGFTGTMTVNYRRLLISGSSALFYIDLEKNEGRKVSLLPHNTSVICGLFQVILKATLQDNDGVEYSNATAVFVTPVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XEP9</accession>
    <name>A0A6G0XEP9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_005537</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000071">
        <property type="protein sequence ID" value="KAF0738609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XEP9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004873"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169:SF2">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0738609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="34197" checksum="B3710CA342565FDC" modified="2020-08-12" version="1">MKHCLSFVDETEETCMFDPMYGYVHLDEKWFWLDELTKKVYLPADEEEPLRSTHNKNFRTKVMFLCAVARPRYDESTGRWFDGKIGILPFVESVPAVRTSRNRPAGTIETKSVAVTKAVYREYLVNKVLSAVRSKWPVSMRNMPIILQHDNASAHDVFDEAFQAQCNVDGFSICLQFQPPNSPDLNVLDLVFFSAIQTLQFEKEATNIDEMLRAVDEAFLEVDITTLENVFLTLQSVMISVLDVRGYNNYKMPHLGKAKQRRVGQLPVSLPVSRGLVAMCVEEIEEYDMQSQFESLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XHX7</accession>
    <name>A0A6G0XHX7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_004859</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000063">
        <property type="protein sequence ID" value="KAF0739691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XHX7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005373"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002259">
        <property type="entry name" value="Eqnu_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332:SF10">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01733">
        <property type="entry name" value="Nucleoside_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="384"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0739691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="814" mass="89615" checksum="FC24DF9930A7CD9E" modified="2020-08-12" version="1">MDEEDAAKINVTFTLQESTDSLRAKPPQRYSPRLLNTLFAIIGIGYLFPFSALTQPVDYWHVLFPTLNMEFYITCVFQYTNLIALGLVVSFGSTESLSYTRRIVGGFTGQLVVLVFVPLASYIFSNETPLAATILSATAFVAVATAFLDSCVIGLAATYPVHAQEALQFGVGLSSFIGSLYRDLTKLVFPENAVKTSSAVYFYTGAFTICICIAAYFVLLRLPVPSTQSHEGYEPASSGLTGASRWTIMRKCLKSLLTVTFLFMTTLCVWPPLVTEIQSFNFPDLQASGWWPLILLTVFSVIDCIGRLLVPYRLGLTKDNLWKPVVARVLLVPCLVMSVRGIWFTHDAWSVVFVALLGLTNGYLGSLSVVFVTENVDVDEERAIAGSFTGFFLSAGLVIGSTVGLGFSKWVVPSVEMEDAIVVVVNGIGMPILVRTYGQAQMPPTSAVGVVSAIFHAALHSNDNQYVVESIETAEFRVSYRQCPTDSILIAFFHSKLLIPAAHAKQILRWLDRFVHLVVRPSILASNDVSVQKFELSKHISLLDGIMTRRRDLQLTIDVPLITWPTSSVPFHPSSVGISFPTDMFIAADSVLLAEYFSLESSSKPLDNWQVVLLTVAAELILETPGREFMTFPVYIHQELHHVTVVQLSSADHVVWFAVAKEVIVPTSIASNIHRWYQAASCVLSRPWAMPHDALPSETGLLCFCIMRLDPSPLCRAVVGLQTPMHLENLFPKDASHLPKTQRQLYAFLSDCMIQTSSRGQSPLNRIVSTADLSVVHAVRAPLWLVFVVAEASLSMSKAMRIADDLACEFGSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XI25</accession>
    <name>A0A6G0XI25_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone deacetylase complex subunit SAP18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_004505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000056">
        <property type="protein sequence ID" value="KAF0739922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XI25"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011264"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.550">
        <property type="entry name" value="ASAP complex, SAP18 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010516">
        <property type="entry name" value="SAP18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042534">
        <property type="entry name" value="SAP18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13082:SF0">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13082">
        <property type="entry name" value="SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06487">
        <property type="entry name" value="SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0739922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="145" mass="16490" checksum="E3D926EA6D3F0AB7" modified="2020-08-12" version="1">MRVVERLGDDRPTSGAQNRDAVRPPQEVDRDVTCPTLVRVFCNSSHYRPEDFNNMQAKPLANEYHVYTWLDATLREIAELVQDANEEARKRNRLAISLVYPDRRGKFIVKKSGLVNTNRKGPDDDKTLASLGFQNGDFLDVAILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XI79</accession>
    <name>A0A6G0XI79_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pentatricopeptide repeat-containing protein-mitochondrial domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_004448</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000055">
        <property type="protein sequence ID" value="KAF0740003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XI79"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015614"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050872">
        <property type="entry name" value="PPR_P_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057027">
        <property type="entry name" value="TPR_mt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46128">
        <property type="entry name" value="MITOCHONDRIAL GROUP I INTRON SPLICING FACTOR CCM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46128:SF211">
        <property type="entry name" value="PENTACOTRIPEPTIDE-REPEAT REGION OF PRORP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23276">
        <property type="entry name" value="TPR_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="150"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="224"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Pentatricopeptide repeat-containing protein-mitochondrial" evidence="5">
        <location>
            <begin position="227"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="536"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="568"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0740003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="593" mass="65868" checksum="214D719540DF03C1" modified="2020-08-12" version="1">MLRQVSKQSSSLLRTALRLSSSHVASSNAPLTLALPQGCQIRAKSTALPTIDGAAAVTGASHNAMPESLLYNQQSFAFPFQPAVYDVPGRHHYGKEVSAWMYKELSELLSSGSLDYDMITDMITILSERNYYREAMEALQFSRQNNIKPRITAYSRIISSCYHHERYELALQVFDVMRRDGFVASFVTYSRALSSATKANQHELALQLFRDLMADCVDLSLESQSIACNNILNSCARHDDLDTATWLVLEMKARGIPLTHVSYNSFVLCIAKCGSMVELKHILDEMSEAGLFLSSAGYLSAITACARWKKWEQVIKLYDEMLQVHGTSFVVSIAAAMMAHVKVGQPQTTIQMYNDSLANNVELNTFAKQAAVTAFLNVGAYDQALALCEEMLSGVVRTDEFFGLVHKLKVQALIAMGRIDEGLALFDETKESMDKTVYCYRMLISHYAQQRQYDEANKYCKRLFDENQYVASSDWIQALSIAIALPDKSSYWEFRRALEVRGPDVLSSIPEGLFLESSKNGCAVSKSNNTAPKKLLASTQSSRASAPLPRRLQTEPMPKTPAKMLLASTKSSSMSTSSTTKSSPPKGKSFKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XIE3</accession>
    <name>A0A6G0XIE3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_004488</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000055">
        <property type="protein sequence ID" value="KAF0740047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XIE3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017669"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="entry name" value="Sodium:dicarboxylate symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42865">
        <property type="entry name" value="PROTON/GLUTAMATE-ASPARTATE SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42865:SF7">
        <property type="entry name" value="PROTON_GLUTAMATE-ASPARTATE SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00173">
        <property type="entry name" value="EDTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="Proton glutamate symport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0769">Symport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0740047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="560" mass="60214" checksum="9AE6DF31F5C88882" modified="2020-08-12" version="1">MSPAPTRRMSYASSKTSGSRQGHPPYETDFVRTNYRSTAPATATSQHGTAYESFESPAAILEPSKPNLDFGSRSTQLQPVFVLVGAVVGVGLGIGLYYSNITPQWIMLIALPGDLFVRALQCLIVPLVLCCMSIVVTETIALGNSSIIRWRNLLPYLASSLLSTIQGFSLALLFKNHFKAPKELVHEQASAPSSYPITMQCAPGMMLGYASNGTLTCVSANATGFNETFWMTNQTTAIAASSTSSLVQQLSLMQQIVGICNTIVPSNIFASMASGSLLSIVMFAIPLGYSVAKTTHSDNLSTNYVLTMLKQLRDIFLLMLNGLLKVTPFAVVFLMAGAIARFNTVDLTKVMSEMGFLLLAFIIGAVCHALVVMPLFVYVVTKANPFAYLRHLVPAYVFAFGCSSSMATLPVSIACIQRAKVSRTISQVTMPFGTPVNCNAAGIYFPLVAMFMANMSNHGADWTSVRLVILFLVSFLGCMGTAPVPNAGLVYSVTLWSTCFPGVALPKAFALVMTADVLMDRIATVLNVNGNAMVTRILAHLIHEMRAVHSSHPVDSEALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XIE7</accession>
    <name>A0A6G0XIE7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_004358</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC35F solute transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000054">
        <property type="protein sequence ID" value="KAF0740119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XIE7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012189"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009262">
        <property type="entry name" value="SLC35_F1/F2/F6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052221">
        <property type="entry name" value="SLC35F_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14233">
        <property type="entry name" value="DUF914-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14233:SF4">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06027">
        <property type="entry name" value="SLC35F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0740119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="37797" checksum="897897B433C8B9FD" modified="2020-08-12" version="1">MPISDVLRRQITNFTYGQVISILLVCTNIFTNKLQRNDALVVTFSTTFLYVFLALVCIPYYYIKRCKSVDLPWWFWLLFGLIDVEANYWSVAAYKVNANYAILGLILHLTIPIVTVLSYFFMGKRYNWFHFVGCFFAIGGVCVIFGASTGDYSDEYPNQMKGNLKAVLAACFYALSNLLQEFAVKRKDTGLDANIECLGKMGFTGTIVSVIQMACIGEYGRVRDVSWTGANVGWNVGYVLTMFAFYLTVSVFLRVTESLLFNISLLTSDLYSALSVMWIFDGVVPHLYWLAWALECVGITIYSVYEPVDLKKHTEESVAIETPADDAKEVYQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XIW7</accession>
    <name>A0A6G0XIW7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_004492</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000055">
        <property type="protein sequence ID" value="KAF0740051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XIW7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017673"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="entry name" value="Sodium:dicarboxylate symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42865">
        <property type="entry name" value="PROTON/GLUTAMATE-ASPARTATE SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42865:SF7">
        <property type="entry name" value="PROTON_GLUTAMATE-ASPARTATE SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00173">
        <property type="entry name" value="EDTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="Proton glutamate symport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0769">Symport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="339"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="378"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="416"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="460"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="489"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="519"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="23"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0740051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="589" mass="63147" checksum="E7A1850BC832441C" modified="2020-08-12" version="1">MASKPKDGILLFDESITSMPTRRISSMSSLSSMSSFSSGKASSKGNAPYESDAVRTNYTSHAEPTNKTQQGADYESVESPTAILETRPSKPNLDFGSRSAEFQPIFVLVGAVVGIGLGIGLYYCNISEQWTMLVALPGDLFVRALQCLIVPLVFCYMTIVVTETVALGDSSIIRLRNLLPFMASSLLATGQGFCLALLFKNHFVPPAGMNSADDLDASSAVLLKCGQGMMLAYASNGTLACVPAGVTGFNGTFWMTNQTAAAAASSTSSLIEQLSLMQQIVGMFDTIVPSNIFASMANGSLLSIVMFAIPFGYAVAKTTHSDNLSTNPILTMLKQLRDIFLLMLNYLLKVTPFAVVFLMAGAIARFNSVELGKVLSEIGFLILAYIIGVACHALVVLPLFMYAITKANPFAYMRHLVPAFVFAFSCASSMATLPVSIACIQRAKVNRGVAQIAMPFGTPVNLNAVGIYYPIVAIFMANMSDHGDEWTPVRLAILFLVSFLGCMGTAPVPNSSLVYTVTLWSTCFPGVALPKAFALVVSANVLMDRTNTMLNVCGNAMVTRVLAHLVREPEVDHDCHPVEDKTEEIGVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJS4</accession>
    <name>A0A6G0XJS4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_003963</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000048">
        <property type="protein sequence ID" value="KAF0740586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJS4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010246"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0740586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="480" mass="54000" checksum="780A4D67C44F3482" modified="2020-08-12" version="1">MRRDPHSRFSLGPLHPSQKTRVRRLGETLLNQALVECETSLHRLEQHWKFVRNYHGLKIYKAKSKHAPSEIMATSVFPASVADIMQCLYADNTLDMRMHSALLMPKERLDCEVLYPLDVQDETHPFRFNGLKWGAMQWPNKGGKSRDMCYFESTGMAIATDEFGREHDYGYCFMESFELPQCPQLDAFSIVRAKVSIRHIFRELPLGGSVVMTHATVDPKGPIVPWVGAHATIPPQVLATANMTECAQALRLSAKLRLQFAGALVPITRNPSWRKLSFLLNQRHSCALCLREESTLERHRVVEVDGIGVKTSWKHFCQKCLAASVAQYGPSLDVSQSSLCMSGYESSNSSPATTPGAAFDFEDVDEVHHPGLAFSKSDLSRRDQIFLSETESSFDSSSPSPREHDDCCHLHRTNSSVAMQLIRLTKKMDNVWGMVCQNKTQADFIKSSPSTQRTCACRACVLSLRLIHVMLLHVIFDAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XKA0</accession>
    <name>A0A6G0XKA0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_003989</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000048">
        <property type="protein sequence ID" value="KAF0740612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XKA0"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0740612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="123" mass="13330" checksum="9403FD6C22DBC3C0" modified="2020-08-12" version="1">METLRVYGTLAMSEQEDERRPLRIATCSSLRRLLCSIRAGIEPPHGPPTKMTACVLAGHANFQCKPRVYVDGVAPLSPPTGPWMHPGLPKTLRNKCVVLQPANLFGSNPLVGSQPNPETFAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XLF8</accession>
    <name>A0A6G0XLF8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_003400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000037">
        <property type="protein sequence ID" value="KAF0741284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XLF8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020845"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="1">
        <location>
            <begin position="7"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0741284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="197" mass="23051" checksum="BBB48AE0289D8A13" modified="2020-08-12" version="1">MDEYLEIHLLANRTVIDDIGDKKVKYTNYIIYIKNLSTGNKYSVQRRYSDFYEFRHQLLAILNGGHCAFCTQCYAHVKAYPFPRRTPLSWQLSVVQERIDGLTLFIKDILRDLLGGTFRQCMHADTNLRHKVLRSFLEVEEQQLQKKVLVAISHETKPERTRSFPHLLDQQHRTPDVTPRRKVAADTCPSCLSKFIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XLL5</accession>
    <name>A0A6G0XLL5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_003452</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000037">
        <property type="protein sequence ID" value="KAF0741341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XLL5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016726"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007849">
        <property type="entry name" value="ATP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28106">
        <property type="entry name" value="MITOCHONDRIAL ATPASE COMPLEX SUBUNIT ATP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28106:SF1">
        <property type="entry name" value="MITOCHONDRIAL ATPASE COMPLEX SUBUNIT ATP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05176">
        <property type="entry name" value="ATP-synt_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0741341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="267" mass="30328" checksum="0D097B4167B81570" modified="2020-08-12" version="1">MKHRLVVSSSILRYASTDGQGETKDQRPPRAKLVSKVHEPITYQADKSVVENWKVAMKAMDEMMQDIDAKKPKQYMPNKFKEMKEYNDTDGKVVVSKMELTPVSQAPEVPALKVQNLNNSDYDLRNLTGGKLTLLLTCFKNSGFDNLLGWRESFEKAFGAKNPMTQVVQLNIIEEWYVKLMPGMIRNGLRSKTPEEHHNLTCVHFGRCDDFRAALDLNNSFVGYVQLVDAKSRVRWTAAGTITPEESTVMNLLSSKIISEISQKPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XML2</accession>
    <name>A0A6G0XML2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">KRR1 small subunit processome component</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">KRR-R motif-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_003161</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the ribosomal small subunit (SSU) processome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the KRR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000036">
        <property type="protein sequence ID" value="KAF0741476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XML2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004513"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22393">
        <property type="entry name" value="KH-I_KRR1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22394">
        <property type="entry name" value="KH-I_KRR1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000011">
        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000014">
        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041174">
        <property type="entry name" value="KRR1-like_KH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048550">
        <property type="entry name" value="KRR1-like_KH1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048548">
        <property type="entry name" value="KRR1-like_KH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048549">
        <property type="entry name" value="KRR1-like_KH2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024166">
        <property type="entry name" value="rRNA_assembly_KRR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581">
        <property type="entry name" value="HIV-1 REV BINDING PROTEIN 2, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581:SF0">
        <property type="entry name" value="KRR1 SMALL SUBUNIT PROCESSOME COMPONENT HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17903">
        <property type="entry name" value="KH_KRR1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21800">
        <property type="entry name" value="KH_KRR1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006515">
        <property type="entry name" value="KRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 8" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="K Homology" evidence="10">
        <location>
            <begin position="128"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="288"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="294"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="328"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0741476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="359" mass="41378" checksum="56B4687051A0CB43" modified="2020-08-12" version="1">MSDGEQQTKGKKHRKDKPWDTDDVAHWKVDAWNDDDNKTGMLEESSFATLFPKYREKYLREVWPIVTKALDNVKVACELNLIEGSMTVRTTRKTSDPYIILKARDLIKLLARSIPVNQAVKILDDEVQCDIIKIGGLVRNKERFVKRRQRLVGPDGATLKAIELLTNCYVLVQGNTVSAMGPYSGLRHVRKIVEDCFQNVHPIYNIKTLMIKRELAKDPKLSGENWDRFLPTFKKKNVQTKKPHVVREKKAYTPFPPAPTPSKIDKEIESGEYFMKEHERKEMKKAKKHQANMEIKEQKKVDRAAEFVAPVEKKRKRDSSTSGPSVQELKEKFLAQDQETKASDKKKKKKVSVADFVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XNQ3</accession>
    <name>A0A6G0XNQ3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RxLR effector protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_002967</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000032">
        <property type="protein sequence ID" value="KAF0742032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XNQ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019627"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026212077" description="RxLR effector protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0742032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="120" mass="12976" checksum="77A285C80494F467" modified="2020-08-12" version="1">MRVLVPLVLAASAVVALNQRGRVAYANHFTMMAHDRLLIDEFQPPPSPKQNIYKKNGRGPEELKYRKKGGKIGAVAGIPLLIAQPMVKRAGKEIGAAYGRSKDKQNAKNAAGGASRSKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XNV9</accession>
    <name>A0A6G0XNV9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DZANK-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_002849</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000030">
        <property type="protein sequence ID" value="KAF0742182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XNV9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000775"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025874">
        <property type="entry name" value="DZR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12773">
        <property type="entry name" value="DZR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DZANK-type" evidence="2">
        <location>
            <begin position="5"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="DZANK-type" evidence="2">
        <location>
            <begin position="212"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0742182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="286" mass="30007" checksum="58D0F28BE3BAE53B" modified="2020-08-12" version="1">MTVPCHACRAENAPGSRFCMSCGASQDAPVVPTATAVCGQCGTTVANVKFCPSCGSPCASSHTATPQPPRRQHSLDMSDVEERRQQQQALRAEQERRADEIVAAKRALAEAKFAALERQTNTRGPPPTLPHASMSTFKALAGTPPPPPASLSAVFRPRAGSTGARHSGMMCGQCGTDVTGLKFCPSCGTPAPPPLPTPAISPMPSVSTGSSCRQCGTNTSNMKFCLECGTPVQAPSHINVTPVVAATTRCSQCGHDVTNMKFCLECGTPVQSRVPQPGRHYTQQIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XPH7</accession>
    <name>A0A6G0XPH7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_002727</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000029">
        <property type="protein sequence ID" value="KAF0742325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XPH7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005371"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="397"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="432"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="238"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="240"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0742325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="597" mass="66815" checksum="FAEDE7E9EC23059D" modified="2020-08-12" version="1">MDSLAIKTELERALSVEEDVTKWTKELYHEISVWLDKALESEMDDPRDKHVIGAATLVQAALQACTAFEKMQVKQMLSTSPSSEDLRICNTKSIAIDECMRILNGLRSMMQFTWNDTASSSEGGGSFFQSKSIESRASEIRVRVIEVRQVYRSIDVDSDNVDECLHLLNEVTSKYDALESHISTDTVTLKQTNSVRLQPTAVDPPTWTELQLPLAQSKTEVEQGKEVSVPALALDIGPQTEKKDEVTLAKGKSDDGKANNILTPPSKLRAKREQRQAAKQRRASMMASTERNQTSHDEPVSTEMVQNWRAAKFKAKSDAEKKKQEEVIKARADVDQGDDDSMEELQRRADARKFLVKYDGDVWTATRAGRLDIVEKFFLVESTTKLLSLHDKNPLEGRRTLLHSAAWHGHVHIAKYLLRLGAEVDAVDTIHSKTTPLIEAARAGHMEMCQLLLTLGAVLTHQDAHASHRKQISQPDNFSRETQLCTGLQGGIGIVLLHPWVFSIENYQGFTVLEVGTPYLVDVAKKTFGVTAVVTREQRREATRFGLKKMQRQSIRMVVPSVEHRGDSLDNIVQAKANVLDGLNKLGLGLESFAYTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XPZ7</accession>
    <name>A0A6G0XPZ7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_002479</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000026">
        <property type="protein sequence ID" value="KAF0742578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XPZ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016132"/>
    <dbReference type="OrthoDB" id="66957at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0742578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="272" mass="31302" checksum="21DBE418F0F55C11" modified="2020-08-12" version="1">MEATKVERWHEQRKIVDVEMARRVAAENKAMQRKNLRRVQSKINQRRYRAEQKCMTEHLYKTVTALNTEVARLEGRLESLRLTIPVSLRTFEPETSVAKEYFHVFCNGYRSDETDPVHKHQHDFLTSVMKQDLVFMGRVGIDKLLDQWSLYSKSFQSVEMVCQGVEVVSFSPNVIIHGSTVLRLHISIATIEMLFPHLRHNELLTTKLVGRELSVVVQHIFEFDRNCKVQRFETHSNLVTALLTLLGPLDTAAALNGIRMSISGEIVASDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XQQ8</accession>
    <name>A0A6G0XQQ8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">fructokinase</fullName>
            <ecNumber evidence="11">2.7.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_002261</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-fructose + ATP = D-fructose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.4" evidence="11"/>
    <dbReference type="EMBL" id="VJMJ01000023">
        <property type="protein sequence ID" value="KAF0742864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XQQ8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013649"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd24067">
        <property type="entry name" value="ASKHA_NBD_ROK_BsFRK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000136">
        <property type="entry name" value="Putative fructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000153">
        <property type="entry name" value="Putative fructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051804">
        <property type="entry name" value="Carb_Metab_Reg_Kinase/Isom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049874">
        <property type="entry name" value="ROK_cs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42742:SF3">
        <property type="entry name" value="FRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42742">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR MPRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0742864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="293" mass="31136" checksum="655D8B096790B6AF" modified="2020-08-12" version="1">MKFAGVELGGTTWALAIAHDSPLNIVARTRIDTTTPEETFAKAFAWLDTQSFDAIGIASFGPVDLNHKSSTYGFITTTPKPHWGNTDIVGVFKARYPNAPINFETDVNAPALFEAAFGGHGEVSSLCYITVGTGIGVGVCIDGKPVHGMMHPEAGHMYVPLATEDIQAGFRGTCPFHGSCAEGMAASGAISSRLQVDRTALTSVADNDPVWDTVAHYLAHVCVNLTLTVSPQVIVIGGGISKRTGLLEKIHAKFDSYLNGYVKTPPTNAFIKVSFHKDIGLVSSLELARMSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XQS4</accession>
    <name>A0A6G0XQS4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_002363</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000025">
        <property type="protein sequence ID" value="KAF0742661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XQS4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011001"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0742661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="100" mass="11392" checksum="6F53D533E2139E8C" modified="2020-08-12" version="1">MGLYSFHATPGTLKSVNIDTPGVCTHKPVKPQYVVAANLLQTNFKDVLDNAKKGVKFVRVHTALLVRFRWHQDNTFTSGHAKRARRLPVATRWYSNERCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XQZ1</accession>
    <name>A0A6G0XQZ1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_002236</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000023">
        <property type="protein sequence ID" value="KAF0742839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XQZ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016349"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33946">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33946:SF4">
        <property type="entry name" value="COAGULATION FACTOR XI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026328381" description="FZ domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="413"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0742839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="446" mass="48396" checksum="4335E30E5D239B06" modified="2020-08-12" version="1">MQSIVATTCLLAATALAENNTWIMKPVHTIQARVQAFAPVFDNGPGHNTFVADFVPTAVTFQDRYTVSMDTINTASVEGALMYLQAEGIDYAVNRPCYRKNNMSYIWFYNITIVQPTFMLAEFQDTQMPEYGPFVAMDNGICTPISAQVPVPAECQEFDGLNNYPKLGPFIGGEPRNADPRAPYDQNIWFSFPNSCYLKAFGAKTAECRKAQTGGMCPRGKQPDGITCTYSFEVMGYLAIDELVGITAMQNSQGKNYSGFVEFCKDNKTEFDTRNLNMSIPFWMDPYNHTANQERSKTMMDLYNINAKKSGSNMIPLPEVKDLTAINPPCYLNSKRCYDAPNGCRRKLLAQVCEVCTDSSADCVKKPANAAPFPSLIKAEKKVPAAALVTNTTGAFGKNSSQGFVPGKPQTTASGSGAPSGSQGSAAVSTMASVGVVVAAALALML</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XRF7</accession>
    <name>A0A6G0XRF7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_002188</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000022">
        <property type="protein sequence ID" value="KAF0743133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015831"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF15">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25764">
        <property type="entry name" value="KIF21A_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="6"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="559"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1140"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1188"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1265"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="419"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="728"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="839"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="919"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="992"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1053"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="577"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1140"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1163"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1210"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1267"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1321"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1346"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="81"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0743133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1410" mass="160087" checksum="FAC712BD243CDECF" modified="2020-08-12" version="1">MSTETSVRVCVRVRPLIPKERLEDEHLAVETFDNQIKVASQTFTFDHVFGTESGQEDIWPCVTPLVDSVFEGYNATIFAYGQTGSGKTFTMGSGNSAFVSNPDERGIIPRVLQEMFGRIEAKKAAGNGYRVELRLRFLEIYGEEIRDLLSQFGNGTLDTSSKVNLKEVQNGQVQVQGAREEEVNSAEECISLLDKGTFCRTVGATEMNSESSRSHAILTLTMVQYIPYDIPSTEEGGEADAPTEFDVRCCYFNFVDLAGSEKQKMTKAEGQRLKEGIDINKGLFVLGCVINALGDDTKRGKVHVPYRDSKLTRMLQDSLGGNSRTLMVCCVSPAGKNIAETKSSLSYANRARNIQNKAVVNRDEQSSLVADLRRQIQALEGELFAFRHPGADMNDPKIQAVVASSDWRLDSFSSLRSRTEGAEAEVMRLSGELKRWRNEMDAMKEELLATQAQRDYFRLCCEELKGRAGGGPSPVGPEGEEMGVIQEQLRTIKNLQERLRVVESERDKAHIYRASSGTLDFSAFEMSADAIQEEQKLIEQAEQEIKRESELLKQLQAMENSTLPPPAPTSVKTEETLNPDEDEPMGEDTGTESMDESVDASSEMVAMQREFQERQQVLGASVQDLSTNISLKEHMLQTLRKNAEGYERMRGMFEAHVAEMAEKERSFLAERERLLSEMQKIQNQATDPRYQKLSSDLQNKDGELGALRKKQAEMKRFESLKAKSDVQLRVLTNEITAMKKQKVDLLKKMQSERKKYEQEASERKREIINLKRAHQRDRQQILKLGSEKDAQERVLKRRMEEVAAANRRLKQQQLLIQANAKEKKKTPQKKYKSKDEEWLAEQIQKLADKQKKAELLEKELDKREKIVQQMERLHGMRAKLQNELKASMEERNGSNIRDILISPFKQKPEGQQSPVQGLSKDEEAMLAELEERIEACQAQLEYKNERISEMTSTNDTDEQGEAMVKVENSSLPEARTLLKLLFNMAVDVRNQEQTKEAELERSALQVQELEKHLRMEKERNHVMRETYEEKLQKMIADAMNEPEDPTSKNRLVASAVEERNHLLRKKCEELESQQMDWQRQSQQLIERNAKYQQGLATCRERIKWLENQLNASKRGEAVPADDMEDMHLMDDDFAETMSVGSASSESNFPTNTQGGATAEGGSSIFNRLSNPNNFTGIHRHRLQENAMQKREEIKNKSQPLRTRRLKDRNIQSASKLRQPNSSVLSPRGRVSTPRPRTTSEDFITHQRHGSAVMDVLAIMKKEKEMDGQDDYDMEEDQSDTMSEGGYGMESPRYRGKKDMDTMSEGSPRSARASKKDVFSRLNGQYTASAQYKRQSYVGNEKGSASRARDAARDKHNVSPTMDEHGVARLSNAPLSAPATSPETTVDPMTGRERFVVQVMDDLRKKTDDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XTA7</accession>
    <name>A0A6G0XTA7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP synthase mitochondrial F1 complex assembly factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_001510</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XTA7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004257"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3580.10">
        <property type="entry name" value="ATP12 ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2180.10">
        <property type="entry name" value="ATP12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011419">
        <property type="entry name" value="ATP12_ATP_synth-F1-assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042272">
        <property type="entry name" value="ATP12_ATP_synth-F1-assembly_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023335">
        <property type="entry name" value="ATP12_ortho_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21013:SF10">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21013">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2/ATP12 PROTEIN, MITOCHONDRIAL PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07542">
        <property type="entry name" value="ATP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160909">
        <property type="entry name" value="ATP12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0743867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="31945" checksum="0DBC1EC30756A20B" modified="2020-08-12" version="1">MMQRVSSSLRSVAGAAAIAPQNVLAASFSQAAAPKPRGGTSSGSGAKIAGRSRFYKVVGIEPEGEGFCVTLDGKRVRTPARSLLQLPTKSLAAAVAMEWDAQRETIQPSTMPMMALASTALDHWDFDFIHQELMKYLQTDTICFPVESQHQEKLAARQEKKWAPLRKWFETEFGGELDVNHGSISKLQHDAQAVEKVGEFLQSIDHFELMAFRLIVRECKSMVVALALMKRHITAKEAIELGRLEEEFQIERWGLVEGGHDLDRANCSVSVHSASFFLWLLTERSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XTV7</accession>
    <name>A0A6G0XTV7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LamG-like jellyroll fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_001333</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000011">
        <property type="protein sequence ID" value="KAF0744070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XTV7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002765"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044623">
        <property type="entry name" value="HRD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45084">
        <property type="entry name" value="ERAD-ASSOCIATED E3 UBIQUITIN-PROTEIN LIGASE COMPONENT HRD3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45084:SF1">
        <property type="entry name" value="ERAD-ASSOCIATED E3 UBIQUITIN-PROTEIN LIGASE COMPONENT HRD3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0744070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="992" mass="111227" checksum="99EB2A481A8BBB78" modified="2020-08-12" version="1">MWSFVGPIQPSPGHVQLMLVNVDDSRNIIVDSDVVLEPILIDEIQHGSDLPASQHIMCEFDTTFCVPKVISMIVPNRPDGVLMAGDVLEIEFDVHTNQPPVTTKSDLEAILEFPDTLGDQIVGSWKSPLLLVLHIISIQNELWIRNITRTPVVRRAPDRWKTWHFKSTEIMYRIASAGHFAWRISHDGIPHQTDYDSPTIEVRSACPLAKIVLSAQAVEDKEFSKPTLQVKGIIALDSVHFLQFPHSSVVTDGEGSWSMLWWLYVTQDATGRFRTLFYKGTGSDQHRTPSAWFEPQSRKLILRVSTELDMDVGMTSIGQVPLHVWTLLGVTFQNHSEPIKNKTFTYTLYINGRVDTDMHVQYSEVIPNSGNLYFGGNPWMDGIQGLMANFRLFSTVLTTDEVLRVYLQELGSMQSRLTIPGQIASLSSMTAKVKSPQQFSFELIDHRSTKHVDTKALIENGFACLEGTYPFAANSTKAAMYFEEAFRHGEYSAAKILGLIYSIHDDAQDVAVALFHLAASHGDLSAMMILARRYTLGDGVQADKETAVFYYYQSAVDSARAYHIRGEQPLHEMNSLFHADEINVAEGEEGENDKWIQFQKLRADQDGEIDAMVAMGDLYYWGARGCPRDHVQAFQYFERAARLESSVAMSAAAGMLLKGEGVTQDNETAIQWYERAAKHNDVRALNGLGYIHFYGTANCTQNQTKGLEYFERAAAQRTDGDSIFNTGYCHYLGLGTDQNVSKALVYFEDAAKSFGHFDSIFELGKAAMNIDGLHERRIDDALLYLGVASAGGDWGKVARQGFDAYLKKQYDRAIWKYHEAREYGYEVAAGNLAYLYGLVGKNSSKYLLEAKEKEASLRLGDCYYYGKGGVSQDFDMALVWYSRASADGLSVGAYNVGYMTEYGIGCVPADAMRAKRYYERALELSPTWEAWFVISVSIYRLQIRSWFGLTPGDVEFQPATSPPKLNWDDIGLGSICIALAGVWSLQHLRNRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XTW2</accession>
    <name>A0A6G0XTW2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_001335</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000011">
        <property type="protein sequence ID" value="KAF0744072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XTW2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002767"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035368">
        <property type="term" value="F:selenocysteine insertion sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040051">
        <property type="entry name" value="SECISBP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13284:SF4">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13284">
        <property type="entry name" value="GH01354P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="232"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="149"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="163"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0744072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="585" mass="65079" checksum="8228953E62CEF8E1" modified="2020-08-12" version="1">MPPKQILQRVKREDRSSLEFPDPPQVNPTKINTRRWEKFEQRVGSEEPRVTSSKTTSTSRGKANVVKAEAKAPVQPSLSQSMPPQLKVGRSWESNTNQLPPPPLKTNEVVTKSDPYVNTSRSKRERAKMAPKVQATNLSLGDFIIPKKQNKTKENTKGAIASLPPPPPPSSATPHNPPADAIYTPQVVTKKKKRPSTLKKRVIRDREEKWIAYHASKLGENPVVQLNPQNISSVQVLHLVDPDEVEDEDEYGDTLDDTKRQFQTHGDVQTIEIDRSSGTVTVEYANPESASAAVSAFNNIKFGGQVVSCYFYNPDNMASLVIVSVQGFCEPEELADDDELEEVLSDIRQTFSSPHIVQDLTVDRSTGEISLMYSSPKEAKEVATIFHGKTFGGKPIIASWNQNEVPPNEAQVKIEVTNIPPVRRLPNAQEIREYVDQGVDKGGEMETMVIAFLNRLMSLQERARLTNPLKAKKSRRLVFGLREVKRGLKTGKVVCLLVAYNIDECASEGGMDEKVIELINLAREMKITVIFILSKRQLGKALLKTIRVSCVGIYNVDGANELWSELKAKVKTLQSAPDSPEENSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XTW5</accession>
    <name>A0A6G0XTW5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_001489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XTW5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002728"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026032358" evidence="1">
        <location>
            <begin position="26"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0743843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="242" mass="25213" checksum="BC9855BE3F0262E3" modified="2020-08-12" version="1">MQPIRSVYLVLAIAILAASAPSGGGLGGFAGFPVGVPGTSFFSNANANSAAKVNSVQAADNHFNNHVDSNAGNQALQEDVVFVKNNANTVANDNGFQNAVSKNDAFNHNNANQAANGAVFFGRRRQLGADTECFGCGGVGIGGIPPSGFNNAEQAANAANGANYFNQANQGRNTNAHQGFNNKRVEKHNLDQESFGNVNADSNAGANALSKGNFFNENQALAARGVAQNNGLFYRRLRAFSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XU49</accession>
    <name>A0A6G0XU49_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_001592</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XU49"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018092"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0743952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="21603" checksum="C37015654015DB12" modified="2020-08-12" version="1">MLVGPTDHNDFSQALVDPSAIWEVVSNAIDVDCFSFHVNGLTHGLPYRFRLRARNALGWSPDGEPSNAFFTHAFLPPTPPEAFSKTHHSLEIAWADQAADLNDMIDMKEYFEVQVCVLRKYCAHDAIPEIHIETWDVVKDRCVERKCVVSNLSALTWYCFRVRSWIRYRGWTEFSDPSKPIQTLRRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XUG0</accession>
    <name>A0A6G0XUG0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_001339</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000011">
        <property type="protein sequence ID" value="KAF0744076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XUG0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002771"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051052">
        <property type="entry name" value="Diverse_substrate_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942">
        <property type="entry name" value="METHYLTRANSF_11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942:SF4">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="4">
        <location>
            <begin position="47"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0744076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="259" mass="29761" checksum="992261F6919B08A0" modified="2020-08-12" version="1">MSQRRLVHAVAKSGFVNGNFYDKARPNFPIECLYAIPSSLTRTSPVVEIGSGTGKFTELLASRFDNLTTVEPSEGMRSAFAEKFPSIPCLEGTAEHLPLPDNSQDAIYLAQAFHWCSNIDALQEFSRVLVPRGHLGLVWNLEEAQTPWVKELRSIYERFDGHGPQYRTMEWEKVFRDLSIFEYPLKHIRIQRTIPVDSVDQIWDRVYSKSYVQTQPEKEMEGLKAELHSILVSAAFTRDGERRILYPYVTDVYLTRKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XV59</accession>
    <name>A0A6G0XV59_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_000826</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009451"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="342"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="406"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="543"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="467"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="628"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="715"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1014"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1166"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1600"/>
            <end position="1750"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1798"/>
            <end position="1900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0744338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1923" mass="216361" checksum="EF792454186DFEA7" modified="2020-08-12" version="1">MTASIVRGWEWAMHALWAEGDLKCNVRVVDTVFLDAASGQPTRWLFASKHGTIAKKKDDHLDLSSIRDRFLRLSMHPRNPNSYVAHALFRNGSRVLVNAAQFDELLFETPTKSRGLVGLQAHVVSAAHETLVASVKGSQCSVSSVGEPPVVSPRLRKEIELAATEIVRFLEATAHVSVAKLDAEFAVDDDNVLWLVHLAQVTTSDKKLAASQSLPTLHAVEKSDGGAKCRGEFCRVACHALPGLFPSAPQTLPPLEDTGQRFKIGYNNIALARLEMHFLHANAASNAEIALEWAAFDAAQRTELGRSNPSHFYKHVGVCANCNRIYAHLQTLRQNHFRHPDAADDHRLEAPPPRQEAVKKAKKKRFQGPPCSNNGEKSATDDVMPALLQLSQDQQHEAAFLAELAKHSTPRQNDVKLPEEEDAAPPRHERPPSKRKDGKKRAKGPSSAENYVLSHFQAEWNQVESANRSLVQENHDLRTQLELQERQHSHERHRLTQELTTALETNNVLEKQSKQLQKRIAAMQKELADAKDEMLQRRLLETDNKPATSSTEISIKRQEGGGGGGDQLSLIETIEQLTAQLDREMRERQGEMQKIHAAHELETARIYDRHKMETEALRMSIRQGVDALEELKTQLVTCQNQLHVAQTQTKQAKTLLSDAQHAKLALENQVAALEKQAIVATDAKAKATSNNDALEKLHHKIDYLKAQLASEIRCKEELGTTVATLNANLDAVKKERRKAVADVEDSHRKILERVQERHKQELEMLQTQNAALQGKLVQLQANVTDLVADLSAARNKEDNARLTTDKLAEESVRLHGRIAELELQNEELQEQVNGTKSSLEDAQRANLEATLRRLTHERQYLKNQMEGEARHKEDALAQCKELQTQLQDATFAWKQDVAAVKAAAKEREQALVEQLTKAQEAQVVSHGEATNARHQLQEIKLTLFKTREQAAADQTALEASRTDVAHLKASLIAAKDELLHERERNRQTSDRNAKAVQAVKASLVQVEQDNKTTITALQSDLQAANAKLEQTQASVVAMEQTHATESAKYKRDVALHRVVASMLERERLGTQRRWWQWRVHAQTHRALAEQGAKMANALKARESTWHERLHTACNELVEKAALEKELALAALQETLEKASTDKLMQLRAEHAAALQSAHDEDKKERVEALDALSKQHALAMDRLEEQHAETIHALQERARESQLRSDKALVAAVEEAQDRERRLIADANAARTQSLREMQDAHQNELKQLGADAAHARLELIQAHEQAMAQACATAQAEAAERAREADERGEMGANDWEMQWMEKMETFFARERQRWQDEHSLALQQLMEKQSIELGDVVQHWTSLLSHERATHAANVQELRQAFDAKLAAEMESCRQEMLEQKGSAVMSTTAKWQRALADTNARLDVEKKVAYDKGVADREAEWQKAAALIKQAQKDEIAALERDSKRALDACEEKFELQLAAKTAEIEHAFAAKLVVHDEDAQADMERAVALEREHMQAKMEEAIAAVVAEWREKLQAQKIALEEELQKACKETEAQVRQDCNVSFEAAKMQWEAGKAHELAKLQSALREEFATTAAADKSAFRIELDAQVQKLEAEWAAKLEAETTRLSAEAAATLQEELRVCADAAAKQHEEEIAFVQEESEKLIEKVETAMQQLKKQKETTEQELKSVQQALEEAEDASFDLQEEMTLLKKQHVFHHMMLLHAARKKMQHFEDEIDSMEMEKKTEIAAWEQKLDETTRALQAKLESAFDTNSKLEQVYSQVYETLVNYKRDELVAHRSASNVVTSELGVLALQIAEVSKTKADGEDDIQKAQAELGALEEELSAIQLMKDGHVNQAQVARKRRMHQEMEAMLESIETKRTKVRTVDAKLQDLHKLHKQKEDEMKNLERQLVQILVEQQKQLLALVTSAMATAATTPKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XVT1</accession>
    <name>A0A6G0XVT1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_001224</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005209"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000289">
        <property type="entry name" value="ABC transporter G family member 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000528">
        <property type="entry name" value="ABC transporter G family member 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="476"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="515"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="556"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="592"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="678"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1096"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1124"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1168"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1207"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1237"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1341"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="84"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="758"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="709"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="736"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0744770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1366" mass="151203" checksum="9379158A6E790550" modified="2020-08-12" version="1">MTSGEGLVANEPNKAKHAISPEGFLANGSDHFHETIATTLEASLGKALPQLELRFRDIAISADIIVASKEGTNELPTLFNHAKKSILGLSRSKNSVKKTILHPTTGVLKPGTMTLLLGQPGSGKSSFMKALAGVFYTSKTTRIEGSITYNGKTKKDLDRRLPQFVSYTEQRDHHYHTLTVQETLAFAHNCAGGVVPQHVLNALTNGTPEENAEAKQIIEALYAVYPEVVVQQLGLTNCKDTIVGNAMLRGVSGGERKRVTLGEMEFGMKQVSLMDEISTGLDAAATFDIVKAQRSAARQLKKTIVIALLQPGPEVFELFDDVIILNEGHVMYHGPRASALSYFESLGFRRPPYRDVADFLLDLGTSQQDQYVVASAASVPRLPSDYAALFRQSSIYHESLSYVDAPPHPNLIADTANHMASTPEFYNSFVTNVMLLIKRQLTVMARDRAFVISSIVMALAMALLYSSSFYQMDPQQAQVVIGVIFQSLLFFITSQVPKLPIILENRKIFYKQRDANFFSTLSYVVAHSLSHIPFAIVETLVFGNIMYWMAGFVNDAMAYVTFMLTLFVVSFVFSAWFFVIGCISSDVNVAQPLSILSVMMFILFGGFIIVQRDIPDYFIWLYWLNPVAWIMRELTINQYSVPEFQVDVYKGVPYKAIYNLTMGDAMLKTFDVATNTKWIGYAFYFMVGSYFVFTFIAFVLLEYQRNDSENHTGASSENDIGDENSADYKKMPDTPNAGSPSHLNRSNEVHSAVVPVTLSFRNLGYAVPNPKKGEPDLQLINGVSGYALPGTITALMGSTGAGKTTLMDVIAGRKKAGKITGEILLNGYPATDLALQRCTGYCEQMDIHSDSATFREALTFSAMLRQPSEVSTEAKLAFVEECLSLLELTNLGDTIVRGSSLEQMKRLTIGVELAAAPSVLFLDEPTSGLDARSAKLVMSGIRKIASTGRTVVCTIHQPSAEVFEMFDSLLLLKRGGQTVYFGDLGAKASSLINYFTRIPQSPRLVDGVNPATWMLECIGAGVEVKTQTANVDFVEVFQQSSEFKNLQEGLDRYARPSADAPELKFAKKRAANPATQCQMLVQRFMRMYWRTPSYNWTRIVVTIFLSVLFGLVFCRLNFYTFAGATSAAGMIFMTALFLCLISFNSVLPLTTTDREAFYRERASQTYSAFWYFVGSTVAELPYVFFNGFLFTAIFYPFVGFKGTFGDAVFYGFNLSLMLLLNVYMGQLMSYAAPTVEAAALLGILVNSIFFLFMGFNPPALSIPSGYRWLYHITPQKYSLAAMTASVLSKCENGEGMGCGLINDLPPFAWQGLGKTNTTATMKEFIEYVYEMKHDDALTNTVAVIGFIVLFRVLGFLALTFINHQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XW15</accession>
    <name>A0A6G0XW15_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_001189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XW15"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0744734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="414" mass="46267" checksum="510B05F013AD1E8E" modified="2020-08-12" version="1">MKIKPIKLHFDRPCNSDWPFEYQSTNQVKCLPSSRMGLARLVVRASEHVTSTDIGFFFFFFLGGFSSSRGSTTSRGSRASSSGESRRISQVSLERIGLFEREVFQFDGNGDQRLEGVGQRVRDRGQSRETQSQREGSNVAETTSELFDQVFFGQVQDSRVEDGTVVVDGLDDQTVRERTDVQLLEQHGFGVTDLFTLLGQQDIGHDFNLTLLNLGTDLQSLEKGGLTGVATSRTSRAPHIDRGNSTDTSRGRDLVGFQSFTDLVQVFVGEDETNIALQQRNHGFQRMARVLLHVVGEDLADHGVLAHQDFSLAAQSDTDLLDLVRANVVNTDDEDLVVGVQQVFQLGEVFGLAFHRDTHLELFTTESSLTWSRRHASEVLMTASWDLPTSKRLVLELQYDIFIPNNLIFVGELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XW83</accession>
    <name>A0A6G0XW83_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_001212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XW83"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005567"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0744757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="27956" checksum="0706334E72E7A6C3" modified="2020-08-12" version="1">MAMVQATSMGFSPFHPNHASTTAISTARESVYSTESSRSPSFAKRSAQDAGLSPRVKEEWPDMDTHVVIKSEPQDDISIDFADIRVSPSEMDDILSKVVLHVKHETSRDRRREAIERRNRRRNIVPKTSLDHKAWLELKRRKSRIAAASYREKQWTKLKLIKQEISLLLTQYPSLQCPSWIPSHAPVLTCRPDESREDFRKRKNRESAALSRRHQLEQLQFFTYQLERLRQLTSVYKPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XWN2</accession>
    <name>A0A6G0XWN2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CLASP N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_000558</name>
        <name evidence="4" type="ORF">Ae201684_000559</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000003">
        <property type="protein sequence ID" value="KAF0744974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VJMJ01000003">
        <property type="protein sequence ID" value="KAF0744975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XWN2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008286"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0744974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0744975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="354" mass="40104" checksum="0743584687D512A6" modified="2020-08-12" version="1">MTTALLSTKVAACCETLSLQEAWVFAKKPQLKAVRNAFGETPCESNEAIVVDSLLPLAAPMAENLLPSWHTDTIQTTCALLVMFVMVLGVFFRPFADQVVVPLLSAGRKMRRRNMEERVANTNLSEWKLVDQMLWQSVETCLDMMSSKSRYDLLPILDYYGACHSVSVQCLVLRQVEIVLGSWTKVELEPYFDHIRDLLHNAMHDRHLDIRMAARAAFSNFCHTWSEHMDELRQIPPPAMSHLLFEFHGGHCITDTLANEPSVVVEEEEMKDVANHDARVDDLVDVHLSLVMYLLVFLTTPLWSLSLLVGGLLWPVGISTKAQVVPMPSVDLLSEDQQSRDTIDPNKDHWYEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XWN4</accession>
    <name>A0A6G0XWN4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_000688</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000003">
        <property type="protein sequence ID" value="KAF0745118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XWN4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008835"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0745118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="147" mass="16874" checksum="86B04A811A75D883" modified="2020-08-12" version="1">MMAKANVVPATPSRHELMQESRRQCVAAAKDLDIARSGWREAVEDLSKVQKRIEQWKAANSDYEQTHPELVRLANERKAVRGCINHAAQSMKDAQERWKKSWNDVCERNPRPSFCTAKDAWNADEVCRRGALEWKQVKLKTVSPSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XXW4</accession>
    <name>A0A6G0XXW4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BAP29/BAP31 transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_000374</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XXW4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005268"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040463">
        <property type="entry name" value="BAP29/BAP31_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05529">
        <property type="entry name" value="Bap31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="BAP29/BAP31 transmembrane" evidence="2">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0745348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="132" mass="15377" checksum="F4B217EC877DCA0A" modified="2020-08-12" version="1">MSMWATWAYVLLPPAVVLLLLLTIPFPKFIAKGIVRMNDYLFSLEVAGIPIISVITFFAFVALAGQTYDLQKRYAPIQGIEKHYQADLQQKASRWRSERNWWISALTFTIYWMLMAFQSLKKQLLTANRRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XYA8</accession>
    <name>A0A6G0XYA8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_000180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000001">
        <property type="protein sequence ID" value="KAF0745731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XYA8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004163"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0745731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="276" mass="32408" checksum="5332EBA059F90A2B" modified="2020-08-12" version="1">MTKHVNDMEPAQEDVETQMGKEFAYKWQEVLSSKPWTRYSQSFVSFLPPTSNARKHFNVRLQRFFAAHGRALWERYFWIGTYTCEEHVGPCRRLVAARAALGLLMFELYQLEGVYPFLFLDKFPHPYWPNLLEHPVHLSRATKSNALIYLVEEHAKRWPDWSKYIDPKNEDDPKDEEGYNPCESFMMWATRRSDGSCSADNWLEAGATPMWFSMVLEELNAMEPAYNAFESPYISVVLPEGVPKRWNCPNIPPGKWQWDWNIQRAVKRPSMNTVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XYB7</accession>
    <name>A0A6G0XYB7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Actin-related protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_000513</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family. ARP2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XYB7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002463"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10220">
        <property type="entry name" value="ASKHA_NBD_Arp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000005">
        <property type="entry name" value="Actin-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000150">
        <property type="entry name" value="Actin-related protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0745499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="389" mass="44617" checksum="5C7F260E3DFE10DC" modified="2020-08-12" version="1">MVAANKIVVCDNGTGFVKCGFAAENFPRHVFPSLVGRPILRAEEAINRDVLLKDVMCGDEAAYVRSNLQISYPVENGIVKNWEDMEKLWDYTFHERLQVNPKDMRILLTEPPLNPKQNRERLVEMMFEKYGFQGTHISIQAILTLYAQGLRTGVVIDSGDGVSHVVPVYEGFVPQHLIRRLDVAGRHITQYLIKLLLLRGYAFNRTADFETVRQLKERYCYAALDPIVERRLALETTILEETYELPDGRIIKLGRERFEATEALFQPHLIGVEGPGLSDMLFDMCQKADIDLRTEFYKNIVLSGGSSMYPGLPSRLEKDIKDRYLADVLKGDKTRLSKFRLRISDPPRRKHLVFLGGSVLADLMKDVDDFWISKKEYDEQGVRCIEKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XYR4</accession>
    <name>A0A6G0XYR4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_000183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000001">
        <property type="protein sequence ID" value="KAF0745734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XYR4"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0745734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="193" mass="21582" checksum="8A1B08D4523695FB" modified="2020-08-12" version="1">MPHESLPPTKVTQLHHATSKLQTASDSASKTLVALSEAAVELAQMADKYNNKTSRRCDHHHHNSESKAYIINDFVKFLSDTVEVRNPCLLKSLAHAYLTGEVESVNEFVDKGFHIVLYAKHASNSVKRLPHEVKFPSRLAPCHPDKLKFQETSFPYSVQTPPKRLKTSEASQTSPTRHAKANDTRIGDDISLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W2J0</accession>
    <name>A0A6G0W2J0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_019240</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000546">
        <property type="protein sequence ID" value="KAF0721032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W2J0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014753"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF18">
        <property type="entry name" value="RETROTRANSPOSON, UNCLASSIFIED-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="4">
        <location>
            <begin position="179"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0721032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="718" mass="80700" checksum="C0EB79BDD4D49ABB" modified="2020-08-12" version="1" fragment="single">MFDQMEASTKSKVNTVCLPNGGRVAVEGVGSVILTVKCDLTDQRVKIKLNGVLYMPKFNRNLISVRKSAKAGLKFNFETTEDHLVVMSNSQSITVIGDPQEPLYILKHIRADESLEKAEANAMVAHPTFDLWHKRLGHLNPVAMKRLLDKGVVRGFKVVQSDLDGWICDACELGKKTRRVKLPSSAASVNRCNAKVHSDLTGPIETPALDGSRYVCLFVDSHSSFITCYCLTKKSEFNELLVQHRAVIQNKHNLPLSELHSDNGGEFVNKQLKDFCAKEGILHSTSVPYTSQQNGKVEVRFRDVFAKARSMLIDGNLPKQLWDHAVQCEVYCLNRCPSGTRKTTAFELWHGYQPNLSAMRVFGSLCYVHIPSKVNVSTDAGRAKTKRQKLDYKAVRGIFLGYAEDRHAYKLLDCTTGQLLVSIHVTFDELDSVASQELKRKELLKLAQIHDLTFDFYSRQASQDVDFLFNGETTLDDEEINALESFVQQFSIPENDLGEINLAAPHGSHLVFHNLDFSPSNSKLLKLSRLQAQSEELVRAEVEMAKAEAYSAAIPASSIPIPRNYEEAMTSKEWEHWKAAIEMELAPIKPNGTWKYVKPPQDRKTLKTTWVFRVKEKCDGSIERFKARLVVKGFLQVKGLDYDEVFAPVMRLESLRTLLAIGNALDLPIDQMDIDTAFLNGTLEEEIYLDLPEGLQMKDVIKDANWEGASELTSSPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W301</accession>
    <name>A0A6G0W301_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_019184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000461">
        <property type="protein sequence ID" value="KAF0721292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W301"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007164"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0721292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="223" mass="24389" checksum="B9D6467E80BB8D28" modified="2020-08-12" version="1">MTNPANNANTPPDADPQADKPVGQEPPQAETDSTDDDDVKASSEAVSFDERRRRASDRKSSSLPTANVWQHFAKQRQAAAKAAKLDIGYHRPTMEQLAPVLLLAEDPSTTGRQLFEALEASLPSPPHPVVTYMQMDVGHLANQIDEGKAMRAVLHDHNNEGIDEGLTDIVQLTVDTTSHQLVWGLASLTAAAILENKVFKIPTRDGSHPFTMKSKKLMDGFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W4N4</accession>
    <name>A0A6G0W4N4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_018750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000352">
        <property type="protein sequence ID" value="KAF0722000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W4N4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016457"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053010">
        <property type="entry name" value="SET_SmydA-8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46455">
        <property type="entry name" value="SET AND MYND DOMAIN CONTAINING, ARTHROPOD-SPECIFIC, MEMBER 4, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46455:SF5">
        <property type="entry name" value="SET AND MYND DOMAIN CONTAINING, ARTHROPOD-SPECIFIC, MEMBER 4, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="24"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0722000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="472" mass="52974" checksum="E15A3DEFB2C2711A" modified="2020-08-12" version="1">MSLLPTDASTIPEAPITYDLSKPLAATEDISVGQVIFYESAFVTSVGPIELEGEHEEECEDSTCPGCERVANLEDDEQEEMSAAAVEEWGEINEYWNTMEIPPSAEVRKHLCKLFHTYEMDSTSLNELLTLPIHEDESNMTAAVGLREAHPAVVPPGLSDDQVAQLIGVLDRYCIPLEEINSTGLFLYVSSLQHSCTPNASFTDAEDALWVTAIKPIAAGEVVTVDFFNLYYSSRADRAEVLEGMHLTCSCDLCLGLSPDRTRAFKCKNESCTDGIVHPTGDVFACTTCGATWDNEAIDAVSKEEIRLMNELIIYTRAELENIIAASPLHRHHYIFYRTFINFMDEAVDEDMPLDQGLEVYKGLLASLNYVVDYPHAQKIHFLNHMAQTCILMEDIELAKSYYEQAYAMSCLVFGETCGETRMFQRFVEHTPQNVAEMREMYGHEDTEDEEEEEEEDDGEEPSVYANFANVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W4Q4</accession>
    <name>A0A6G0W4Q4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_018742</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000351">
        <property type="protein sequence ID" value="KAF0722021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W4Q4"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0722021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="102" mass="11408" checksum="CFB04449E773E365" modified="2020-08-12" version="1">MSGKAAIARHGLMGCLSPAVVNYTSATNIVQEVVANVVGVAKVSEEGLPRCGAEDFAYYLEQYVISFNVWGYEFGSNWTKYGRQAEMWQFFLLLSSVWFCTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W568</accession>
    <name>A0A6G0W568_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_018826</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000359">
        <property type="protein sequence ID" value="KAF0721890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W568"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019308"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01951">
        <property type="entry name" value="lectin_L-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051136">
        <property type="entry name" value="Intracellular_Lectin-GPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056573">
        <property type="entry name" value="Lectin_L-type_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001220">
        <property type="entry name" value="Legume_lectin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223:SF19">
        <property type="entry name" value="LEGUME LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223">
        <property type="entry name" value="VESICULAR MANNOSE-BINDING LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00139">
        <property type="entry name" value="Lectin_legB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0430">Lectin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026302131" description="Fibronectin type-III domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="323"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0721890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="802" mass="87327" checksum="9B38E5AF955176DD" modified="2020-08-12" version="1">MRRRRSFFKLLLSLLSASVSFSQTLEDIPFRTVEALWTFDKGLESWARSASDLMHAEINPQDGNAHGSVLDSPPFIDSPLLELNVVDRHYFVVRFAYDGSCTQAGLHLERSGKTITSSTNPKAPFVNSIVVRFSIVPDGIPHVYYAPIYEFYQGEVSRIRFFPCMSNAQWGHTFNIDWIALIKAPTITKVRGCIDQYFISQDRSNPIADIALVMNLTNDVLPVFNTNFESMDLPFASTYNCMAGDTVRIQGRNFGDTSLVRINGQPCEGQPLISQAILADDTDVEEIISCVLPPGPPGLVTVTVQNERYRGLQFDGAFLSYAVPADLSTSPTVSNVMAYAVDITWAPPPSLWTSLTVTGYEITWFVSSDLSSSKSKMVGNVTTTTLMPLLPSTVYSVTVAAVVESQNTPAWQQVDMYGQRSSLPSAIVGQPSPPLVFQTLPIDVLFSSFLAGSTLNHSAANPLTTLGPTGDVGGQGAFGLTLLGHAHIENCNATSSCCDFDATGTSCLLVCKSTTIRSPSSKAIRTAVSSASASNPLPAKACGPSLRLTGSAPFLTGAAWYPRPLNVREGFDTTFKYRISNPSFDCKNMDDVATHCRARGGDGFAFVVQNVGQEAMGEGGFHLGYGDIPNSLSVEFDTTYNPEMLDLYENHISVHTRGYDVANSGDHSYSLGATSQIPDLTDGIHSVRIRYVPYLDDDQPFHPYFQATAYVSQFLAASEEDSATHILWYTAGLGCLTIDFDDRPVLSVPIHLDATLRLTGGRAFVGFTAATGEKAWQVHDIVSWQIDSLRILPPNQADFIHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W7I1</accession>
    <name>A0A6G0W7I1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_018401</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000333">
        <property type="protein sequence ID" value="KAF0722458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W7I1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014950"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF37">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0722458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="173" mass="20339" checksum="54E8DB25F98B43C7" modified="2020-08-12" version="1">MLACNELVDDLAAEEEQFLQLELDTCFPDLKIEEAVRFGCRPDFAARLKSLLDRYRDYAPLKVHLKDGDKPVRCKARRYSLPQREFMEKHVRDLENTWFVYRNPTSRWASTPLRVRKPHTENEFRMTVDLRPVNAQTEQIAWPMPMLEVVVDHLAGSSWFFSWISSKVIGNLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W8H7</accession>
    <name>A0A6G0W8H7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_017560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000301">
        <property type="protein sequence ID" value="KAF0723593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W8H7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012468"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0723593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="345" mass="39245" checksum="F263288AF315DA2D" modified="2020-08-12" version="1">MADRAMEDSDGMFTPLQSPHEHVTPRRSPYTISQTPENARTHRVSPYPLRVRTPARHDEANTPRPRPQRLVQGPRQQDQPYQLLVKPLVKSTVGQRDSSGLSLDAFVASGRSFSDIVTKLWDAFKPHMKGRAVKIDAVWSLQEMDFGEWKGSIQFKIIKKVVDASKSEHEWNAWLVKMKDKTVTLLIYMYGAALGRQQDLDEFHVACIQPLQTDRSGATVEASLRDVITSLQTQWCASFQAEQVVWRMWANHITRNLNRSTWDAAITRHPPPHIAQLFQPVASHLSQHIENLTRSANMALDCVAASMADLQQLRRYLDICESNLTGRKPSLKHSYVISHLSQLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W915</accession>
    <name>A0A6G0W915_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_018261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000327">
        <property type="protein sequence ID" value="KAF0722662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W915"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018205"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08267">
        <property type="entry name" value="MDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050700">
        <property type="entry name" value="YIM1/Zinc_Alcohol_DH_Fams"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695:SF294">
        <property type="entry name" value="RETICULON-4-INTERACTING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="13"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0722662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="315" mass="33571" checksum="4A1927F76CBEE263" modified="2020-08-12" version="1">MRSVKYDIWSSTGRRFDTDAAKPSLEAKDSVVVDVKAAGINPVDYKLPKWFFHGKGIGLDFSGVVTQVSPDVQSVAVGDRVFGNTRGALSEQVVCNASHIAKLPTTFSFQEGAALPTAYLTSYQAFVNHGFEAGMKVLVIGASGGCGSAGVQLATAMGASEVVGVCSKKNEEFVKSLGADRIIDYQTQSIVDGNAQHFDFVLDTATASGGGENYLDDAKKVLKDPSKNHVALNGPPSLWLGRLTPFGRKDIDLIMTEHKSADLEGFLKHLEQAGSRPVIDSVFPFTQEGVEEAFAKLASRRVKGKVVVDVGGQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W9F7</accession>
    <name>A0A6G0W9F7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_017424</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000296">
        <property type="protein sequence ID" value="KAF0723752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W9F7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012881"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173">
        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173:SF74">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="36"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="69"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="102"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="135"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="168"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="201"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="234"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0723752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="288" mass="30763" checksum="82DD5D3ED94F0D44" modified="2020-08-12" version="1">MSTLDEVLIQASFLRDVESIQELLAQGAKLDFSHVLGRTSLHWVSFIGYDRVVSKLLALGASVDVTDSLGDTPLHLASARDHIEIVKMLLNHGAKVDIANKDGKFPLHKASEKGYLGIVKLLLAHQAAVDIADNFGQTPLLLGSENGHLSCIKVLLAHGATVDIPDTHGRTPLLLASMNGHANAVRVLLNYGASVNVADNYGRASILLASEEGHVDIVQELLNHGASIDVQNLDGDTSIILAAKTRNLKLVKTLVKAGANLSVANKEGKTVRDIANISVRILLKTPQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WA19</accession>
    <name>A0A6G0WA19_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_017963</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000317">
        <property type="protein sequence ID" value="KAF0723092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WA19"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015261"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169:SF2">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0723092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="21601" checksum="EA27504ECF8BCE2E" modified="2020-08-12" version="1">MFDGKVGMWPFVSEVPAARNLRNRPAGMVMTLVNVNATVYHDFVINKVIPAIKASFPSANKRVVLQHDNATPHGSITDAELAAVSTGGRQFVLRRQPPNSPDLNVLDLGFFASIQSLQYKTMSRTVDDVIRATLSAFNDLSYEKLESVFLTFQVVMRLVLEHNGGNHFALPHLKKAALRRAGLLMTNVSCPVSLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WB91</accession>
    <name>A0A6G0WB91_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_017076</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000278">
        <property type="protein sequence ID" value="KAF0724177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WB91"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020205"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0724177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="779" mass="89662" checksum="0E4EB0C3B4275090" modified="2020-08-12" version="1">MEPPEESTKPIGVTLAFVHAFVEHQGGRDAFEKLTTADVCSSFVLPFTNSTKLSLVDHVAQDPTYGSDYVRPAQWFISHAWTYQFLDVIDALDYFFTENGLADTTAFWFCMFNNNQHEIQDNQRDSSYWFDIFYSSLTSIGNVVMVLSPWNNPETLTRMWCVFEVYASIMANARFEVALGKMQKEEFLKEIVQQDNAFFRMLARIKSETSETKVEADREFIEAKIRADIGFSRLDRMVFEVMESWIFRTLETQSNLPTNAPAMQAKYLEALGSIHLNARRYPQAKEHFTRANDIWHQENTPDKWRSQSEVAIAMAVCQEPRSEWEPLFQEALEHQEIELGSDHRDTAITLGYYGVALGEYNEYSRATELIKRAYESQQKTSANDVMMAIDCCLNIGKMCMFQSNYIEAAKWLEQGYEQSCLVFGPDYKSSLMLRNHLAIVYGVHSRYEDCLNMLLESYNSSVRTFGPDHIDTWQVLSKSVTVYCSLGQYDQMERVLLQCREKFKATEGLDTQWYLKCERDLGKLYYFREEYERAAPLIEMAYRELFAKKNFLVFHTIYDLYHLKLKTHGLDTLEDLAAYEKILEDSSCTDETWKAHPCRGCFVLVRGRRFVCAECPTDSRWYCAPCVADKKCLCHLNDTSTNKDCGCCPGRPRGRNTTRPLKHIKLTATNTTLTIAKNEFNRPARSSRAVLFHKAPKKPQVDFAGLKSTRNLLRLALPGVKLSDQTAKASSIYTKRTTVAEYTPPKRVLIAVPKLPSEPEPGAVFVWLYTTDSSIYDCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WCF4</accession>
    <name>A0A6G0WCF4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycine zipper domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_016550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000258">
        <property type="protein sequence ID" value="KAF0724874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WCF4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005245"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026063390" description="Glycine zipper domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0724874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="151" mass="15301" checksum="EB34A696B48466C5" modified="2020-08-12" version="1">MRVLVPLALATSAVVALNLRGQDSPLVFANQVVAPMHSPDDLRILPDTPQDGGSPRSPRQSNERQRGPKETKYRKKGGKWGAGIGAATLGATGAVGGSFGGPLGAVAGLTGGTLAGGMGGKALGKAVGGAYGRRKDKKDQRNALQRSATMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WCL7</accession>
    <name>A0A6G0WCL7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_017197</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000286">
        <property type="protein sequence ID" value="KAF0724031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WCL7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010566"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF98">
        <property type="entry name" value="FI18310P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026100557" description="Peptidase S1 domain-containing protein" evidence="5">
        <location>
            <begin position="20"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="6">
        <location>
            <begin position="44"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0724031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="134" mass="15205" checksum="4E34D967EE752AAC" modified="2020-08-12" version="1">MRIWLWLLIAFVMLEEIQAQRHPDRPKRPRRRFRSNKKKVKKQIVGGLKARVGEHRYVAGLKGSVNEETSCGSALIAPRLLLTAAHCVLDNIKVAAIGTHYNTGHEGGELIEIAERFLTQSTTTTHRRVMMLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WD95</accession>
    <name>A0A6G0WD95_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BART domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_016498</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000254">
        <property type="protein sequence ID" value="KAF0724938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WD95"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003163"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1520.10">
        <property type="entry name" value="ADP-ribosylation factor-like 2-binding protein, domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023379">
        <property type="entry name" value="BART_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042541">
        <property type="entry name" value="BART_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11527">
        <property type="entry name" value="ARL2_Bind_BART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BART" evidence="6">
        <location>
            <begin position="57"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF11527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0724938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="156" mass="18468" checksum="39364AFEE25E5C19" modified="2020-08-12" version="1">MNFQRLLASAREDVDRETKAVRRPPKACNVISKVLEYMLDMDEDGFDELFEFEQRVLPYFEGDASTSEYRLECTQAHQEFEALVEKKLQAFLARNGWSTDEFHRRMKEELATIDSMEKEHEHAEELVRMIYDAFDFDSWAHSMRYSANHRGASSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WDM3</accession>
    <name>A0A6G0WDM3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phenylalanine 4-monooxygenase</fullName>
            <ecNumber evidence="3">1.14.16.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_016471</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.16.1" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000253">
        <property type="protein sequence ID" value="KAF0725074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WDM3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011729"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004505">
        <property type="term" value="F:phenylalanine 4-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.800.10">
        <property type="entry name" value="Aromatic amino acid hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001273">
        <property type="entry name" value="ArAA_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018301">
        <property type="entry name" value="ArAA_hydroxylase_Fe/CU_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036951">
        <property type="entry name" value="ArAA_hydroxylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036329">
        <property type="entry name" value="Aro-AA_hydroxylase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019774">
        <property type="entry name" value="Aromatic-AA_hydroxylase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11473">
        <property type="entry name" value="AROMATIC AMINO ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11473:SF24">
        <property type="entry name" value="PHENYLALANINE-4-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00351">
        <property type="entry name" value="Biopterin_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00372">
        <property type="entry name" value="FYWHYDRXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56534">
        <property type="entry name" value="Aromatic aminoacid monoxygenases, catalytic and oligomerization domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00367">
        <property type="entry name" value="BH4_AAA_HYDROXYL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51410">
        <property type="entry name" value="BH4_AAA_HYDROXYL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biopterin-dependent aromatic amino acid hydroxylase family profile" evidence="9">
        <location>
            <begin position="39"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601273-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0725074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="374" mass="42901" checksum="FBACDD1E22998BDA" modified="2020-08-12" version="1">MWSHFQRSFLPRTFSGCLISRWPRRLVSSTAAAAPQLSTHELQEPSLAPVTVPWFPQRIQDLDICARNALEVELDATDPGLNDPHYCARRKVLRNLVVNYRQGQPLHHVDYNNLERQTWATIYRTIRPLWLKYACKEYHAVIALLEREINYGETAIPQFRDITGFLEATTGFTMHPVTGYLSPRDFLNGLAFRVFFCTQYIRHHSVPFYTQEPDICHEIMGHVPMFADKDFADFSHEIGLASLGATDEEIVRLAAVYFISVEFGIYRQNGNLKAFGAGLLSSIAELEFACNPNRPAGGRDDFADYRTYCPFEASMQTYPVTAYQPYYYVSESVAQVKVGVRAYIDAMDRPFVAMYDWTTKTILTDRTLVVLDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WE71</accession>
    <name>A0A6G0WE71_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_016750</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000266">
        <property type="protein sequence ID" value="KAF0724687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WE71"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001932"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005216">
        <property type="term" value="F:monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006816">
        <property type="term" value="P:calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015925">
        <property type="entry name" value="Ryanodine_IP3_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13715:SF99">
        <property type="entry name" value="INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13715">
        <property type="entry name" value="RYANODINE RECEPTOR AND IP3 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="566"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="622"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="650"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="690"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="738"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="776"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="857"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="6">
        <location>
            <begin position="595"/>
            <end position="886"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0724687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="970" mass="110129" checksum="C74D4F7A893A6AFD" modified="2020-08-12" version="1">MCVQLLTVIQEIALMASNESTGLTSNVDRKEYTPLLETTATSVAGAVDSRPLVQVIGSLRASLDIESSNKDLDSIDSLTHLLTIVRVLRETREELERLDAKKREDKWSVSFDAEAHAKLLLFAEKEYEDLVKNAIKYDIADILVHMISHNIHDEASHDLLNELSSGGFIFVQNALYYASADHLDAFLNYLSDHLQRDPANTLDIFQQLCVCHHSLWQAVMRAPIRDGPSFIEVILNRIEAFSLNSVSKEDGATLIAYMDFLSEACQGPCLDNQVLISGASQALSSVRDILMDSIQLEPTVDDQVYINIQRSAAEVILTLMEGREDDVVHERLMVFFPVAAVMDRLQAHYHTIQERLYSPSHRSFMEHTVNLTKSLIHSESKDEAQRRMREFLASINLLRIATHLLNDKHANDVTPPGPEFTIFRSQWQEMVTNSKVHDALVFFQEQLISVEIARGARTFTSYFLRPHMAEYFNDSLKTKLIDKMDIGSEEALDVLASEVAKDVEEELTVIQHLNKNPFYSLMNNWNVWLRKNMLRLCFYINFVMLLCVRVDNSTMVDIKSANMHSGLWVVGVLGFVLLGFCSVLWFYFLLTTLCFNYCKQQASPSKLSFTTSSEYWSDTFQAFAPFGVYLEFFIAVFAVVYYMEMFSTTAAAIFGFAVLYLLGLFLSGIRVSSGLYRFTVNSDVGARTNFMLNMLSFWFNVIYDTLVATDVLIFGFYTLCAICGLGLSIPSVTEYFESGPWGLMFFGFPLVDILATNEELRFVATAMKTNLGKLGVTTIFGAIMIYIFSLMGFFLLQSELTSDSVNHCGTLLQCYSTYIRYGLLSGGGIGDYISSTLNNELPLDQPDRYFERLVYDMAFFVVVITLFLNMIQGIIIDAFTTVREQAETKAALIRERCLVCNRARNAIELEGVELGLLYNFSRHTQVEHNLFHYFFYIQSVTSKEAKELNGIESYVVEKLKTKDMSWIPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WEH4</accession>
    <name>A0A6G0WEH4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_015837</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000233">
        <property type="protein sequence ID" value="KAF0725750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WEH4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020460"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0725750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="190" mass="21315" checksum="04CAA4EF134F72B4" modified="2020-08-12" version="1">MFADDEVDYDEYMPPSPDLVRREQSTAPPPVRPKYLDHLWVLEGQSQPGGGVHTRCQASNTGCVLAFNELLGFTALRNGTPDPSKFHDLLAQLPSRLRGGSKEDFVAGIAIAVTLWETCNPVIVNVAEWPLLKHDQRRFGVMHPFVPVSPCRDETMFKYVAIWANRLLARMALDSTSFPHNLRKVPRACC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WEK1</accession>
    <name>A0A6G0WEK1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_015832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000233">
        <property type="protein sequence ID" value="KAF0725745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WEK1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015342"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF317">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="494"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0725745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="602" mass="66762" checksum="FE7A67A46F5B7318" modified="2020-08-12" version="1">MAEIKFPIYSILCMSCIWSYWRLAVPTKPAEEIEAEKWLFLVKKRHGQFSTLRSIRFNRWYLVAMAFLNLFFVGSMVSIDFLDGALNGFFLGMEEEYAITVQVLGMAVMGLSAALAGPFIERRGPRLSMAISTALVVLGWIFAELGVVFQVYPLLFIGIGVFVAVGYGITMIVSVATVQKWFPDLRGVSGITVAGMGGGSLVWINIYGALMHRKSDNIFMQVSQDLDNDGLHYVFLLHGGLALVFMLLATMVFRTPPPNYAVNGSDIHCIPLNKAPATAHVQNNYLDVGMTLVNFDAVGQNQPITTDCVYFSHVKALSLIQCIFSSDFFFLYLAFAASASPIVLFSAESPSYVFMILRATIDQTNDFVLHNNIACALGNTLGPILADAIIRIFYANPAFVRKMVFMVFLLSHSVAIAILKNNIDNINTFQWPLYIASGSSGVGFGLIPSLLSDLFGVYNAGTMFGLILTSWSIGTLVLRVLLRESSNMALELPSHLNALLIVSIVGCVIMGLVRSSSMDRFYRGYQLTICGKIIIQRPSRHLMMEQNNAKPSQESKSGLLPEWMVRHQMTDRERDCSSPIILVHPDCHHLFQTQERPNEPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WF62</accession>
    <name>A0A6G0WF62_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Smr domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_015679</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000229">
        <property type="protein sequence ID" value="KAF0726015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WF62"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009512"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013899">
        <property type="entry name" value="DUF1771"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053242">
        <property type="entry name" value="PAM2-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46651">
        <property type="entry name" value="POLYADENYLATE-BINDING PROTEIN-INTERACTING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46651:SF1">
        <property type="entry name" value="SMALL MUTS RELATED FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08590">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01162">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="219"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Smr" evidence="7">
        <location>
            <begin position="420"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="219"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="304"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0726015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="496" mass="55481" checksum="7DC77FB3B5B95A9E" modified="2020-08-12" version="1">MIAVEAWTAKQLAVLGVDSVFAPYVLGMLNMNGPASEDEEDEKRQEVLDLLMGWLDESHQVQAENFVDELLLYVKDPHQLALLHDSIPSMQNDTTEGTVDDQPQLKATASAFVPSSLEKPLQDDVPPPHSDEFEFDVEDEEAFYWSVAYELVEQLLVIFPSMDPERLLDLLKEVDLNVQRAQATMQGIVDSEQTKGNAQVCRHYLQGDCRRADCWFLHDTHLIPCRYWIRGGCLQGDECAFAHSFAVAVSQYSAQPVEEEDEGNVEDQIEWNFPSLQEGNGMAKVAPSVEESLSLDFKRAVSTSAPRPPPTFSSSFAYQAPTKKQPGKSTTMSITQWVETGDHVAAQYQKARATARDLALARNQCFMNATRAFRANNKALAKSLSRQGQQLNADMKQAHFEAATLIFEARNPQYEVDGIVDLHGLHVAEAVELLAWLLPSIKTRDSICVVTGSGHHSHHQRLRPAVERFLTAEGYTFTSVPDRKGYVGMLNVSLRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WF77</accession>
    <name>A0A6G0WF77_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_016424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000253">
        <property type="protein sequence ID" value="KAF0725026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WF77"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000031"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="57"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="165"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0725026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="349" mass="40169" checksum="C53D134AF51D51EE" modified="2020-08-12" version="1">MLLQHLDECVVQMRACAEKLRSSKVVLSSALLDMKTRDVPQISVKSRLVFDVEEKEQELLEKNKRKFEALAKQAEDQIEKLMAEKKQLEHELRRQSQQFREVLEERDADVQIEYNKMLSELNDHLEDAKQQLDSAIQLRDSKLDLVKDIPSTSHSLATEADLHEYQKLQRKVIARTNEVNELQAEFQALEEELARPLKRKADVLESIPDARERDAEECAKLQEEIKLLVQTEVNLKDQVNQRRLLDIQRAENEKMQREIQELEQEATNVQATLGQLSTRLQAQFRVLAPTSTAGALLTRLHSLVSNSSAPIPLSEFLHMSPNHEEGMRAVELLAEIGILKLENLHLVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WFT7</accession>
    <name>A0A6G0WFT7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_016216</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000244">
        <property type="protein sequence ID" value="KAF0725319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WFT7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017414"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="125"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0725319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="176" mass="20103" checksum="9F6F0656CC412F6C" modified="2020-08-12" version="1">MKEPATHDPHDIVPESESQSALDSEDDFPNNQQGDPELYGNILNGHGFSRKRLSFGTFESYLSYHTDNETPDRSINLLHGENLPNDSEDEDETMLLESDEEDPRDTFEQSLETNIVQQVTTNEMLSQMNTEIVRAFSEVEQMQCELESALMRFNEHKLKVIHTLQSLQGIAQSLTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WGH8</accession>
    <name>A0A6G0WGH8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_015452</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000220">
        <property type="protein sequence ID" value="KAF0726233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WGH8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012427"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039672">
        <property type="entry name" value="MFS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11328">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11328:SF28">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13347">
        <property type="entry name" value="MFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="440"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0726233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="501" mass="54241" checksum="77C08079E13A0298" modified="2020-08-12" version="1">MHPTAEWPLVKILAYAVGHVLNDMCASSWFSYLLVFLNAVAGLSPVDSALVMFSGQIADGLATPLVGVLSDNSEGFPSIGFGRRKTWLTGGSVLVLVCFYLVFGASLPNLMEASPSRLTMVVYYCVGASLFNVGWAAVQVSHMAMVPELTPDDNVRCVLNSTRYAFTILSNVLVFLVFLFLLHDVEPLEVPDAKKFTLLTTVSLVVGGICTLWFLIGTTEKTKKSIVLVANPSPSNADAQTRGPTAFPVEADMPPLVSWNDTPAAARQWSDWFRVGMFYEVGMVYMCTRLTVNVTQVYIPFLLTVTLDMSATSIAIVPMLVYVSGFLATFPMRWMNASLGREGTFVCGAVLIVLSLGLSWFLTQETASWIYLLSVLLGFGNSIIMVTSVCLEGDLVGDNCESGAFVYGAMSFTDKISNGIAVLLIQNQRESITAAEDGELVRLVVCILPTVSIVVGAMTLFWMKHGSKTLVNKVSRSPEDVVPGEVSPLLSGQDRLYGSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WH90</accession>
    <name>A0A6G0WH90_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_015180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000213">
        <property type="protein sequence ID" value="KAF0726555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WH90"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020929"/>
    <dbReference type="OrthoDB" id="2155538at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0726555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="109" mass="12399" checksum="48957698A4152E63" modified="2020-08-12" version="1">MTGRTTKPLEEVLTAEFFDSIVASAPTGADQRDREYLIQTLLPCLVPALKSLLRAEEDVQQRKNKGAMALSIKPLDYLAKYLYRHNPRHAEPTEETLMLQRLAHHLTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WHM2</accession>
    <name>A0A6G0WHM2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_015097</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000210">
        <property type="protein sequence ID" value="KAF0726698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WHM2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012019"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01831">
        <property type="entry name" value="Endoglucanase_E_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040794">
        <property type="entry name" value="CE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037461">
        <property type="entry name" value="CtCE2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052762">
        <property type="entry name" value="PCW_deacetylase/CE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37834:SF2">
        <property type="entry name" value="ESTERASE, SGNH HYDROLASE-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37834">
        <property type="entry name" value="GDSL-LIKE LIPASE/ACYLHYDROLASE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G00620)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17996">
        <property type="entry name" value="CE2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbohydrate esterase 2 N-terminal" evidence="2">
        <location>
            <begin position="74"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="1">
        <location>
            <begin position="186"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0726698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="435" mass="48470" checksum="CCF849C1E39C27EE" modified="2020-08-12" version="1">MTHPMEVVDLASGSDSISSQGQQDDGAQLEVYNFDLSKYKDGSYKLITAVDPMVHLSGRFLKHFENATRKTKVNSVQFDWPHSGFSIHVKHTRSVGIRLKGEGNYFNVFVDGQFTCILRAAIKASCYDVAQFDDDAEHTITISKRTEPQMRGAVSTFKVCTFYGFIVDKAAIVLPYVSPYTHRIEFIGDSDTCGFGNEGAGSSSKGIFGMKGRVENVYNGYACITARMFNAEAHVLAWSGKGVKSNLGEWGPNMSSMWKHAIASRDFPWDMDAWQPEAVVINLGAQDLFPPASSEAEIVEAYTALLEDVRLHRPEAHIFCVVCDENCMSGEEDHVNRSRISLQLQEITRVAMSKVKKMDLRMHYAFIKIPGGLEPRDFANMRHYSVSGHVKFAEALAKEIAFRTEWPVAAPPTTMPYPQAKNQILAPSDKHCVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WIS4</accession>
    <name>A0A6G0WIS4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_014840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000202">
        <property type="protein sequence ID" value="KAF0727103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WIS4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004251"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0727103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="178" mass="19308" checksum="0E68AF97620245E3" modified="2020-08-12" version="1">MSTTGDRCVFPECTQAGAAVATKLAIAVVSAKQAIGSIPASSIPGGLLSSLLGLGKWYEGLSRSRMCERFVTSFQMRVEDEYMFGGNLVGTYDEQSGGNACGPQFVKYYELAQSKGMFPQDWSKQDETSLMANAGKNIHFAVEKSDVTEKFGNTEPMLVRMIAEEILGPIGKWVDDEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJQ1</accession>
    <name>A0A6G0WJQ1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_014542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000197">
        <property type="protein sequence ID" value="KAF0727430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJQ1"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0727430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="98" mass="11002" checksum="ABA97E52065A135F" modified="2020-08-12" version="1">MTYHFSRRLSSDADQKTPKQALSNAESILRGLEAVGTGLQSLDGSLQNNVFYNMADVAEQIERALNPQTNAIERLMQQQADQMAQIMNMLQARESKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WK28</accession>
    <name>A0A6G0WK28_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Proline dehydrogenase</fullName>
            <ecNumber evidence="2 5">1.5.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_014412</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Converts proline to delta-1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the proline oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="2 5"/>
    <dbReference type="EMBL" id="VJMJ01000193">
        <property type="protein sequence ID" value="KAF0727585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WK28"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009750"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914:SF0">
        <property type="entry name" value="PROLINE DEHYDROGENASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PROLINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="251"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0727585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="544" mass="60882" checksum="61736C0D2041700E" modified="2020-08-12" version="1">MLRVSSSSLARRVRNARPLSTATTASVTATPIDKSTRAQPAALSFTETERIFAKKSTAELLRAFAVFQTCQFPFLVRNSQTMIDLSYKIVGSKITDWALKKSFFGHFCAGENAQDIQPAIEKLRQAGIGAILDFAAEADVEAEKKTELDGVSSNELQARTYDYEDEAMCDANMRIALQAIQDAPAGGFTAVKCTAMGKPELLQRMSSILVATQILFHSLDGPVSRAKQSYVDRLVDYPTFKIGIKKAGATFTEEELDTLFRALDVQHDGMIDYVDWVSYLNPMDLTMGPLTRFLKVDPLSAEEIQQMSQMMSRLETLAAAASAANVKLMIDAEQTYMQPAIDHVVLNLQRRYNTNNRDTIYNTFQCYLRDSSDRVLIDLERAEREKFRFACKLVRGAYMIQERKRAADMGYPDPIHPTLEATHANYDSLVELLLVHNNRTSFMVASHNEESVQKTVAKMDALSIPRTNGGVYFGQLLGMCDHVSYTLGAEEYQVFKYVPYGPVDEVLPYLIRRAQENSGMMKGGAAKELALLSKELKRRFKLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WK79</accession>
    <name>A0A6G0WK79_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MIF4G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_014299</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4G family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000191">
        <property type="protein sequence ID" value="KAF0727672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WK79"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009149"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253:SF9">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G" evidence="5">
        <location>
            <begin position="198"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="21"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0727672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="422" mass="45945" checksum="6253BD17CBB70529" modified="2020-08-12" version="1">MSKLNPNAGAFVPSFVVSIDPPAAPSTSPSPGAKKPKANGNAVAMNSVSSTPKSARISPSSAMKPPAVESPSPALSSESKALPAVTSLAQFTQVQTGRVINGRQHYSIAELLQFRPFCSDVPPHFDAAAVHAICGGAVKEKTKSKRDKQRAVAAPHQPPLHYDPNAYAYFASASEADSKTKPRHKPTDNPEQEAKDAVDKVNALLDQLSRPDESVEATINRFHDIPVTCTPSLQAVVGVLFDRAICAPNLCNFYAPFCSGLSESMPDFKDGARTINFRRILLTKCYEALIAEAEQEIWRRQSMLGNVGLIGELFRRQLLTENIMHVCVGMMLDTDMETLPPPPVLQAACQLLQLVGDLLDGSSPASRRTMDEYFDALHRLACHDQIQPRLRTLIHETIEARSSGWIRKRVDVVDVLSTTQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WL71</accession>
    <name>A0A6G0WL71_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_014115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000184">
        <property type="protein sequence ID" value="KAF0728009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WL71"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008926"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF410">
        <property type="entry name" value="LYSINE-SPECIFIC HISTONE DEMETHYLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026150111" description="Amine oxidase domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="2">
        <location>
            <begin position="69"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0728009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="547" mass="60110" checksum="4708A7367D74952D" modified="2020-08-12" version="1">MVSFRLIVAGAVFAQTLLGVSARALDANDTTTNATNSTAATETITFPTTASSIQIQANASIAIIGAGPAGVHYASLLAQKGFSNITILEYSNEIGGKSKTVVDDAGYPHELGTCYTHALYDPIIDLINKYDPTNVLVPFDPMVSGNTLIMSDNTPLYDYPTYAFLLSRNLTGITSITGLQSALQQAFVKYIGLHQSFFGRYSYGLPPQPKDWTQLAGTAAQFIQNNQLQVIQPWFEMLFERQGYGSLASTPAFYLLWWGHPDLVRRYLVASSQGKPWVFMLSNGYQSLWESIAKAHANDFSIQFRTAVTSISQRDTQPQVTVRQWPIGGNPKTDGVVSTLSFDHIVMAVDLSISSPDLSTEKGSPIQITDLDETEKWLFNGYTSAAFVTTKFTSPPLPFEAVVEWWPERGQGAFQGRVQLARNTHMALWNSTAALSAPLNATAAQSRVVYQHYDPASATTSRQTYQATLTSDLASMFPGYDANPTTTFFASYAPRTSTDKLTQNQPWAIWNNQGAHHTTWIGSSVTFESVLDVVTYNQNLIDRVQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WMP0</accession>
    <name>A0A6G0WMP0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_013546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000175">
        <property type="protein sequence ID" value="KAF0728583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WMP0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010936"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05271">
        <property type="entry name" value="NDUFA9_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051207">
        <property type="entry name" value="ComplexI_NDUFA9_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126:SF11">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="27"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0728583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="342" mass="37591" checksum="8D84432069B42AE3" modified="2020-08-12" version="1">MSALSAVARATVKNPPGRVSGSPICATVFGATGFVGRYVCAQLGHTGCTVVTPYRGDDMDARHLKVNGDLGSVAQLPFSVRDRESIRAAVKGSNVVINLIGKHYETKHALPWWINYTYDDVHVQAAKDIAEVCAEENVPRLIHFSSILAKPNSPSIWAASKYRGEVAVRKAFPNANIVRSGSIYGPEDRFLNWYARLGSMIPLIENGSARTQPVNVTDVAQALYALCVDTTINGETFELVGDEEYTNKEIVDYVLDITQHDAQLLNLPLPVAELIGSAIQNLPNPAFTKDWAVRLSLDEVKTSNLPGLRDLQVEPTKMEKEAFSFLFKYNKGGHFQKVDGYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WNG3</accession>
    <name>A0A6G0WNG3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_013474</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000172">
        <property type="protein sequence ID" value="KAF0728906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WNG3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014793"/>
    <dbReference type="OrthoDB" id="2257100at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14686">
        <property type="entry name" value="bZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050946">
        <property type="entry name" value="AP-1_TF_bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11462">
        <property type="entry name" value="JUN TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11462:SF35">
        <property type="entry name" value="TRANSCRIPTION FACTOR JRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="5">
        <location>
            <begin position="89"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="50"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0728906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="304" mass="34489" checksum="90F3260B52DD2874" modified="2020-08-12" version="1">MSHQSEDIQCSVSSCGNPVEAFGVCALHLPRVQPREHKVHAFVDSNHLRIMSNRSPTRNSNNSQCGTPTSAHSGSDNSDEHGGQETVLRRERNRIAARKSRQRKLDKIQHLENEKGRLEGHRNRLVNEIRMLESRMEGSLGSAKKVLSDAEYEALQRNRMRVIEDVHAMYNARNIEESTKYFREDSIVSGPQNSVHLRGKDAIVLDFICTDTLFENFQLNHTKIDCGGPRSQHFRVYWLFTGTIKTTGTCMNQEFQDLFSKVQGKTLTIDGVSNYSFSGDKIVYIHRTADQAKLLSTLVKLSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WS34</accession>
    <name>A0A6G0WS34_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_012292</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000155">
        <property type="protein sequence ID" value="KAF0730291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WS34"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021870"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013211">
        <property type="entry name" value="LVIVD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08309">
        <property type="entry name" value="LVIVD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101908">
        <property type="entry name" value="Putative isomerase YbhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0730291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="297" mass="32339" checksum="8D677B0C545F34F1" modified="2020-08-12" version="1">MYGMVVLDVTTPECPSVLAELIEGQGGMALKHFFINKRIVYTACGKSGLRIFTNIDTNIDEIGALMHSRYGAKCVAVQGDIALVTFGLAGVRVLDVANPSSPVELGGFKDDTHEARFVLLRDGWGFVSFGHSGIRILDVTNGSLPCEISSFSHGSFDARHMALAGPFLFVAFSYGGLKVLDVTNPFTPEEIGAVSFPSYAANCVQVLEDIVYVALGNGGLRILRFHAPRRQFEPLGSYVDAEADITSVHVTDDRLAFACLRQGELKILDVRNPINVREIGAYRPDVRRLLCQHCAVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WT18</accession>
    <name>A0A6G0WT18_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Intraflagellar transport protein 20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_012006</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000153">
        <property type="protein sequence ID" value="KAF0730586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WT18"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002364"/>
    <dbReference type="OrthoDB" id="10254896at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097546">
        <property type="term" value="C:ciliary base"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030990">
        <property type="term" value="C:intraciliary transport particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097730">
        <property type="term" value="C:non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028172">
        <property type="entry name" value="FT20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31978">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31978:SF1">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14931">
        <property type="entry name" value="IFT20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0730586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="15910" checksum="904D1FE16FA528D8" modified="2020-08-12" version="1">MPPPEQQLPRICFDDEYRVRVLEMEKFIHTQELEGECNQFVTKMEEFHNTVKGVLEIMEAQAKRIEIEKLKAIGQRNRVDNEVENRNRQKLMLEVLIKEKQTELERYCQQYASLTKIEDEQQQLIDKLSNNEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WTZ3</accession>
    <name>A0A6G0WTZ3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_011799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000149">
        <property type="protein sequence ID" value="KAF0730917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WTZ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005926"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0730917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="335" mass="38535" checksum="D0BF08CD56BE770D" modified="2020-08-12" version="1">MSAFFESVFHNKTSSESSDDVITLFDASSNTFAMRYIVDIPYSIPLDQVQDYLLLLPGITSFGTGMELYLTTFLTSNTSSRAATKPWHICEHEIEQVDSFDESSPRYNVWAVIYSLETPQLCWFKFIFRWLVAIYVLHVLWTRYYTHCRVLLSNLRCVGLGPEIVHYRVIFGDPAYVILTDPIVSVAIFVDIWYSMPYTIAAGVRVSQFSDLWSYALGCMYLFRTVWFAYLGMRGLSSFIKWRRWESSFAPVDPTFLALISYISGGPMTSFITKTPAAWAFRRTLTVLLTESEKEEAVEGILDVLIYTVMMSTGPIIYSRVAVLWRNYRHGQKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WUQ7</accession>
    <name>A0A6G0WUQ7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Hexose transporter 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ae201684_011528</name>
        <name evidence="16" type="ORF">Ae201684_011531</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-fructose(out) = D-fructose(in)</text>
            <dbReference type="Rhea" id="RHEA:60372"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:60373"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>D-galactose(in) = D-galactose(out)</text>
            <dbReference type="Rhea" id="RHEA:34915"/>
            <dbReference type="ChEBI" id="CHEBI:4139"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="7">
            <dbReference type="Rhea" id="RHEA:34917"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-glucosamine(out) = D-glucosamine(in)</text>
            <dbReference type="Rhea" id="RHEA:78423"/>
            <dbReference type="ChEBI" id="CHEBI:58723"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:78424"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-glucose(out) = D-glucose(in)</text>
            <dbReference type="Rhea" id="RHEA:60376"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:60377"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-mannose(out) = D-mannose(in)</text>
            <dbReference type="Rhea" id="RHEA:78391"/>
            <dbReference type="ChEBI" id="CHEBI:4208"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:78392"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-xylose(out) = D-xylose(in)</text>
            <dbReference type="Rhea" id="RHEA:78427"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:78428"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000147">
        <property type="protein sequence ID" value="KAF0730979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VJMJ01000146">
        <property type="protein sequence ID" value="KAF0731268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WUQ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015074"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="389"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="15">
        <location>
            <begin position="42"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF0730979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF0731268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="517" mass="56726" checksum="FF75AD09B3860981" modified="2020-08-12" version="1">MVIPPTKSAAQTPTTEINEETFPSATKDADNALVASSTMRKSIAAAIIGAVQFGWMMGEMGYLPFNNVKFCAMPRIPAGQCILFPGHSNAEWTMQSTAWAVGGGIGALLSAYPADKFGRKLTLGGNGLLMIAGGFVQMFAGDIYTFAIGRGINGLASGIAINVLNNYLREISPVQWRMFYVTMVQLALSTGALIVTSLMYAISKLPNEWEYKYLFGGPILLGVLQLAFMGFIIESPAWLIQTHQVERSLEVMNQLYQPGDVESHWKAQVESISRQNQEVQSSSKLGLLLSPKYSKQFSIAVVLAMMQQLCGMNALVVYGPQLFQAIGIHELRLSNTLVNFSRFDNMFIAARFGDRFSRRSLMLVGSMGMVLGAVGFTLCQIYHDDTSKWFQVVCMAVFVGSFCFSIGSLGWLMSTELVPETLGATSGAIATFFTWTAQFFLGVYFQQISNVAHWGNHAFFIFAGVNFVFFIFVVAFVPDTNNKTSDQVTALFYTEADKDDDFIVAATPKGFQDADMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WVJ5</accession>
    <name>A0A6G0WVJ5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TRAPPC10/Trs130 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_011133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000141">
        <property type="protein sequence ID" value="KAF0731507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WVJ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001718"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034498">
        <property type="term" value="P:early endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045126">
        <property type="entry name" value="TRAPPC10/Trs130"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056913">
        <property type="entry name" value="TRAPPC10/Trs130_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13251">
        <property type="entry name" value="EPILEPSY HOLOPROSENCEPHALY CANDIDATE 1/TMEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13251:SF3">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23036">
        <property type="entry name" value="TRAPPC10_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRAPPC10/Trs130 N-terminal" evidence="1">
        <location>
            <begin position="42"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0731507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1127" mass="126408" checksum="EE400605AC16D726" modified="2020-08-12" version="1">MTDDGKSRLYERIPLLPQLKNYGYNPSTVAENPYTSERINGVCVNYEDHGGVWQFLYPSLSQRLPLRGIAWKNHLQTTKTIDRLHVNFQQILPAGQQTMDNSTGLVYLFVVKCEDMDTYKMKIKPALSAWVDRMTLHKNEWLVLYVPLGTQASTSSTSRGLGAFSQTFRDSSKIYRKIFERMKIDIADKGEKTKMDRICKIDVLEGSSVQGAVPGQQQQHESQWSEVLIKLKTCIMDAFDSRCLEYEEQLRLLDGKRTMDGWDFSSFLQVKESLALLYIQATLFDDAIRHYDELEAIYTSLDSAPDDQTKRLVNDDPIFMSSPFDLDMTSVRMNIAVNSASPVYIRLYLFCRQVAISYLMDAHVDVCTRALAFIPQMRAMLQQQHPLDVALPLQWAVGAALALCVSCEHECGEAPSPALAKYFGDLLYLARQNCKKLLSLPRQKSSQMSWYHTFQSNEVLDELTSLASLQYAKAGRVRFAAFLGGQCAAHARTHGNRDTPVAQLLLAQMQQYEKDQWWELMHATLLELLSTELAAGHVQEVIDLALHWMHLDAAKHTSSKVLSIWLDALKIAAVQNEVVHVIWTHLFESSIQATEVSSTSVQLQLTVKNTLAVDIPVEYIGIEFDKTLAKSSSFDECLSLDSVLAAEGKKLLRSSTSETMDAIDDFTTYLSEDHEMTKSAPPLERSTTLTTTLASCVFRGRCTSTFTLAIDAVDKESLLPTGPYICRRIVCRLGAFEFSLPLEEPATFVVAPPCLSSLDLEVECPPLILPGTSEPLVFVLDPRRDTFLGGQMLIKCHGAGVKLTCPPNIDCKRTDDDESFTVQLAPASKLFRQVFTIVSTTIQGSIDIDVAVAYAFTDGKHPSQRATKRLAVSCVVAPLVQVATTTKQVVPTLCSIQLDVRCNDRMGIVIHPASYELWVVDKEGMNLLDSEKHHPNLKVVANPNKQLTPMRILPSGTIHAAFLVNVDSAYDRDTTDLKWRFSYSSLDDETTLVFHDVMFPFTLSAVPPQDQFQLVVELDLPATSKVHQRDWVHITVNTTCPAKPVDSTPYWICLDDRSQQHWLCAALATQVLCPKVRFKLLPRHIGRLPHPSFAIRTIQSGSKQQMEALDRSLVRQTPQDAFVLVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WW72</accession>
    <name>A0A6G0WW72_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_011096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000140">
        <property type="protein sequence ID" value="KAF0731795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WW72"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001029"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052289">
        <property type="entry name" value="Calcyclin-binding_UBL-bridge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13164">
        <property type="entry name" value="CALICYLIN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13164:SF6">
        <property type="entry name" value="CS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026107328" description="CS domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0731795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="23449" checksum="6849ACDA90165C3F" modified="2020-08-12" version="1">MRRVFLCLMLSFEVSRSELIRIMQGIVRPQPFYLPRPVEKKHQSEMSNTDGDQPVSALHANIQSKGTNAYYYAHKKRPGADDHQWDGQCEPRLISTGESVIQVSKDRPITAYAWADGKKSVSVYIDIPSIGAHSDDKIVLDWNPRSLEVRIRELDPSGADMVFKIKYLYEEIMGATLKKKDDKIVLRLTKSKELTWYTLKKDHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WX59</accession>
    <name>A0A6G0WX59_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_010799</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000137">
        <property type="protein sequence ID" value="KAF0732149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WX59"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001091"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002259">
        <property type="entry name" value="Eqnu_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332:SF10">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01733">
        <property type="entry name" value="Nucleoside_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01130">
        <property type="entry name" value="DERENTRNSPRT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="312"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="390"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="421"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0732149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="454" mass="50018" checksum="9E10210415A52919" modified="2020-08-12" version="1">MTVEYVAVATPVVNKEIALIADEPVDIEKDEIPQSVIDELKANYNYIYYSFYFLDGAVMWAYYSCLSAQDYYAGKYPTVQFSFLTTMFLTWPLSLGYLLQMWSGLDHALGHRLRMRIGFTAIAAAAVIIIIHGWFGLSETAGAYLCLALFAVCGASHSLSEPVLYIIAGLFPDEKFTNAVQIGDAMAGVVNVVAATVIRLIVGGIKSENGSKANDISFFLFMGLTIIICFLAIYIHEKLSAIPAVKYLLDRAERDHKQKFETMSLPALWSNYFRIAKVIVVPLVAQYLMFFCTLALFPGIGCSASAHVIKDYSVAWYCSPGIVGSFNFGDLFGRMLCSNKAIWNYFSSKTVLILAVLRWVWLPLILMSLFSSPLYSFADAQTFGLIWPVILYFFLGISGGMLATISIGTAPLMVSQADRQAAAALMVMALYLGLSTGSTFGWGIGHNHLFNVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WZ03</accession>
    <name>A0A6G0WZ03_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_010259</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000129">
        <property type="protein sequence ID" value="KAF0732728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WZ03"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003701"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070736">
        <property type="term" value="F:protein-glycine ligase activity, initiating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051437">
        <property type="entry name" value="TTLL_monoglycylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45870">
        <property type="entry name" value="TUBULIN MONOGLYCYLASE TTLL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45870:SF2">
        <property type="entry name" value="TUBULIN MONOGLYCYLASE TTLL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="197"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="919"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="44"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="130"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0732728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="959" mass="109650" checksum="7EE9B1DD89AF7A6D" modified="2020-08-12" version="1">MASVTAPQSEPGALLSPTKKSFVSKIPRRRSFEGSLPPPSSDNNQHDEPTPPKAKMDKHQQYIKELEEKKRKEKEEEQAKADKQCRLRVKLRQSILQRAAAIRSESDEQTKDEEPTQDPEMTEDEKKAKAAAQKKLLQKQQALLETMKAKRQKEAEEAEAERLKARKKKDVTRKAALGNQEVPSRMQDALEKFNQVAAGSAVSAVRVKKEEKSEPVAALTPEEKERRSQQQEAIKRKQVEYLQKLAEDRKLKQQEEDAQQQLLQQKRAKVREEAMLKAEAAKHNKAPAPPPQNEEENKPVEKPKVNVEAMVSRLSKLKASEVQLVPEAKDFASWKKRNGVAQDTKVFCLTGWYPVIKETLEKRGWFHNPDRNSPYFDLKWALKSDDLKNVKLNEDQLVNHFLQNTAITTKVGLLHNLRNITWFLSEDIDSFFPRAYDLNEPSDMQATKQHFRYIHAEGMLKRLGVQCQAFLDQDIPVLANAGVIDVLLAVCLKRQEILPDDALDNSDSCGVEPLVTDLQWEVLTRCNLNGPSAIRAAFVYTKPPPPETSEQPLSPSEQKEEAKLARTQDKLMEAAFAKEKARLNSLLAQVAPLSIESAQEILAILKVLEAHCPQFHLNGADSKNVWIVKPAGMSRGRGIRVFNQLHELLAYADVENHKECQWIVQKYIENPLLVCNRKFDIRQWVFVTSWNPLTVWFYLDCYLRFSSEEYQVDDLSDQFVHLTNNSIQKNGENFYKAYSTEDGSMTVEGNMWHSDDLNEYLNRKFGLDAETGESIFKSKIQPRMKEIVVWSLSCVQDSIQHRKNSCELYGYDFMLDDTFKPWLIEVNSSPACDYSTAVTKRYIETGLEDILKVMLDVREYDMKRKSNQPAKMPDTGRWENIHKGEFIAKPLASFGGSDFEIKGKKMTKKNQRQTLYRRVSDVATIDEDTPMQLNASVDEQEPEAAEPGPVLPPDVDELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X0S0</accession>
    <name>A0A6G0X0S0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-alpha-acetyltransferase 40</fullName>
            <ecNumber evidence="4">2.3.1.257</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_009617</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-seryl-[histone H2A] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[histone H2A] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50600"/>
            <dbReference type="Rhea" id="RHEA-COMP:12742"/>
            <dbReference type="Rhea" id="RHEA-COMP:12744"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64738"/>
            <dbReference type="ChEBI" id="CHEBI:83690"/>
            <dbReference type="EC" id="2.3.1.257"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N-terminal L-seryl-[histone H4] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[histone H4] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50596"/>
            <dbReference type="Rhea" id="RHEA-COMP:12740"/>
            <dbReference type="Rhea" id="RHEA-COMP:12743"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64738"/>
            <dbReference type="ChEBI" id="CHEBI:83690"/>
            <dbReference type="EC" id="2.3.1.257"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. NAA40 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.257" evidence="4"/>
    <dbReference type="EMBL" id="VJMJ01000122">
        <property type="protein sequence ID" value="KAF0733368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X0S0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009101"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043998">
        <property type="term" value="F:histone H2A acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010485">
        <property type="term" value="F:histone H4 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039949">
        <property type="entry name" value="NAA40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20531">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20531:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="12">
        <location>
            <begin position="55"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0733368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="212" mass="24771" checksum="B99DC02006D685E8" modified="2020-08-12" version="1">MPPKTKRLTKKEQQALLRRQLLSNANQVVDFLVEFKAFSAYQMKNSEETMHLRSLHASALTLEEREQIERLFCANMQTLYENSSWGFDMEKKRIELFEPEARYIVVEHPRGQIEAFVHFRFVDDDGDPVVYIYEIQVSSNVQRQGVGKRLMQVVELVARKYKMKFIVLTVFKSNDQAMQFYMTKMGFEIDETSPSAQGDDSESYEILSKALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X1F8</accession>
    <name>A0A6G0X1F8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_009490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000120">
        <property type="protein sequence ID" value="KAF0733645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X1F8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019481"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0733645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="604" mass="68600" checksum="786AF06DBAB80025" modified="2020-08-12" version="1">MVSLKSSSVVKTRPRQPWSPDACMIKVHDIRTIYRCVMTVQDFRFDDSIMVHPEYAIATEIIFACRQFPHEAFISSWITWRTFEEFRVLDHQLRQVPTPPVKALSDSTEPVPRYSWWGRPAADSSAHPMDTIEAPRLHRRRKWLFQHKTKAFMLRRQGELDSYLISVCATPLRLLHFLDVRAPPYLRYFCNFDVAFGAHVARTVWNPSLGVVEHDKLDMLEANLADDARRGIIVCSTYGCQCQFLSLGESEARMAAALAVKQLEVVPWGVAEDHVLAQTAYMCIVQELYSMEDMELELESMGLLSDKPTIVTSSPAVAAADKVRRYMANYGLLHAEAIADLVGLHVVDVKKSFHVCKKAKQVRVGALALQTLATMLNVTITLVTNDHRHTVRHVMPWESLPSLVTGPPRHLVWNYLLPTAQYIHGHYRLLRSIAAPAATLPLMRQDWLAVDEAFVHRMTQVIEANEITVMDSDGTTAEELQQGILDAVWHACDQNPKRFQSFQWTSKQYGTSRMPGAVFFAFLEKLFRPTGAAYITDFLVHVLPLPNKRQSLLRARWSRFHSELMVTRASILHLTSRRSLTLSRSSSFVDSSTASTLSTSPTEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X2N8</accession>
    <name>A0A6G0X2N8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CBS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_009218</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase gamma subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000118">
        <property type="protein sequence ID" value="KAF0734046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X2N8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009574"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04618">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050511">
        <property type="entry name" value="AMPK_gamma/SDS23_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780:SF35">
        <property type="entry name" value="LD22662P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0129">CBS domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="153"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="236"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="312"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0734046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="439" mass="48719" checksum="9587F84683D0A1C1" modified="2020-08-12" version="1">MADQGGGGPRRPSPSVGSNREASRPNVQRRMSDHVYPHHAVGRMSGDEGSSSMDVDMGYGSDGSSGHRSGPVNLQRHVGRVPFSLAAPPPPSSLDRRRSGSSDSVQNFRLDPVANGNLHLNLSMNMDMYARNVVEEGQRVVRAFLHNCKCYDVIKNSGKVVVFDVKIPVNLAFFALVEHNIKSVPLWDADQGCFVGMFTATDFVNILRHFYNRGSLAAVAEYSIAAWKQLSVQLQMAPTDAQMIYISPEESLLEACQVLQHHRVHRIAIFDAEQNSVLSILTHADILEYLVSTFREQRRLFDQSIVELGIGTFTNLVTIPEDTPLIHVLHTMMERRISAVPITDAQGVVVYIYSISDVTELVKDRALSQLDAPVGEILRVQLAEGFVSDNLHFCSKQDTLHMMFEKFAAAKAHHLVCADESNRCVGIVALSDLFNYFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X369</accession>
    <name>A0A6G0X369_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tubulin gamma chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_008989</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers. Gamma-tubulin is a key component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation. The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000116">
        <property type="protein sequence ID" value="KAF0734308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X369"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001536"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02188">
        <property type="entry name" value="gamma_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000004">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000003">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000010">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002454">
        <property type="entry name" value="Gamma_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01164">
        <property type="entry name" value="GAMMATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="10">
        <location>
            <begin position="48"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="11">
        <location>
            <begin position="250"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0734308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="449" mass="50295" checksum="0528CE52262E67E9" modified="2020-08-12" version="1">MPREIITLQVGQCGNQIGSEFWKQLCVEHGISPDGIVQDFATQGNDRKDVFFYQADDEHYIPRALLLDLEPRVINSIMNSSYRNLYNPENQFVAKDGGGAGNNWASGYNQGEQHHDLLMEMIDREADGSDSLEGFVLCHSIAGGTGSGMGSYLLENLNDHFPKKLIQTYSVFPNQDDFQSDVVVQPYNSLLTLKRLVLNSDCVVVLDNTALNRIAVDRLRIDNPTVSQLNSLVSTVMAASTTTLRYPGYMNNDLIGLVASLIPTPRCHFLMTGYTPLTIDAQVSAVRKTTVLDVMRRLLQPKNIMVSTSTKTGCYVSILNIIQGDVDPTQVHKSLQRIRERKLVKFIPWGPASIQVALSRKSPYVESAHKVSGLMLANHTSIGNLFHRSVVHYDRLRKHNAFIDQYKKQPMFADSLEEFDNAREVVTSMIEEYKASERADYATWGQSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X3Q9</accession>
    <name>A0A6G0X3Q9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_008827</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000112">
        <property type="protein sequence ID" value="KAF0734478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X3Q9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000523"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05123">
        <property type="entry name" value="STKc_AGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000008">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045270">
        <property type="entry name" value="STKc_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="65"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="11">
        <location>
            <begin position="328"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="399"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0734478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="447" mass="50370" checksum="6747002249053E28" modified="2020-08-12" version="1">MAETLKLGKESQLMRRESIAFEESTVAILNEQQTQRTSKDADALNQASEDKKGLASATTHKPTDFELLVVVGQGAFGKVIQVRHKPTGEICAMKIVSKEYLVKKNYIANMQTERDIMTKVDHPFLVKLKYAFQSPANVYLVMPYIPGGELFHTLHKEGLLLEHTACFYAAEIVLALEYLHGRGIIHRDLKPENILLDADGHVCLTDFGLSKELPEDDEAKTVCGTNEYMAPEMIRNKPYTHAVDWWALGALIYEMVTGYPPFRHNNRKKLLEKICTEKLSLPKFLNADTHSILKQLLERNVDKRLGSGKSTMFKVKGVAAIKQHPFFKNIDWGLLAQKKLTPPVKPKLNDAQLDTSCFAESFTKMQVSVDDTTDGEHGALFHRFSYTAADFHGRRSSIQVPTEQIDEEETVQSGDDESNPLEDEPSQVVENQANPEEPLESPRNRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X3S0</accession>
    <name>A0A6G0X3S0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_008836</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000112">
        <property type="protein sequence ID" value="KAF0734488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X3S0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000514"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF103">
        <property type="entry name" value="PHOSPHOLIPID PHOSPHATASE HOMOLOG 1.2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="110"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0734488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="274" mass="30273" checksum="AF14A8A94094BAEF" modified="2020-08-12" version="1">MSEEGRSGEKILKQKPLWIEVQWISPLISIIVWASIAGWALSIAPNSRYLDTYNPKISEATSHPFHHDTISYGLLLGLAAAVGVIVPFVVECFVERHPMSKRQFYITLVNLWLGCLEAVLLTIATTEAIKFNVGFLRPNFASVCQPRLVNGSTYECTTNPSEYHKSMVSFPSGHASTGTAVGWYTSLYLLWNLYHRHEGIPSQARAICQQALFLPALAPFLLALAVSVSRVTDFKHHTIDITMGTVLGLVFASVVFVRAVKTLPGRVVVATEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X3Y4</accession>
    <name>A0A6G0X3Y4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_008768</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000111">
        <property type="protein sequence ID" value="KAF0734524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X3Y4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010671"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0734524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="293" mass="32567" checksum="CBD5548375483CB1" modified="2020-08-12" version="1">MALRILRNVARRPWNAKKGEFIGLRTKNYNTRTTSSPPHIKNDLFLVGALLAAGATVLGASQYAWKSNPREAPLVQSKPKIEQDVVAESPKPTAMTPESLVKVLDEIRDLYEAQLNRVKEDAMEKIDDDADAIVDTFVDKLVILEEKIYAKHSTSRSAIEVAIETHQSLPNVAAALARCSASLAPKGKNLLSFEKTLDIIERGFIAFAEASDAVNPESNDLEPAKFEALLGRKVDEAFVSQFQGDTAVNDKSLQLAIQVHSLNPEFRRKLQALYSRYMSRLGHVGEVRRQEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X425</accession>
    <name>A0A6G0X425_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C3HC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_008739</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000109">
        <property type="protein sequence ID" value="KAF0734671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X425"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006603"/>
    <dbReference type="OrthoDB" id="614844at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013909">
        <property type="entry name" value="NuBaID_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012935">
        <property type="entry name" value="NuBaID_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15835">
        <property type="entry name" value="NUCLEAR-INTERACTING PARTNER OF ALK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15835:SF6">
        <property type="entry name" value="ZINC FINGER C3HC-TYPE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08600">
        <property type="entry name" value="NuBaID_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07967">
        <property type="entry name" value="zf-C3HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3HC-type" evidence="7">
        <location>
            <begin position="54"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="NuBaID C-terminal" evidence="8">
        <location>
            <begin position="233"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0734671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="361" mass="39799" checksum="B1DE1C2F04250D9E" modified="2020-08-12" version="1">MNAGGSSTATLLTRVDEVLAGWKNVTAPVKKKTTDVLPPHMPPPKDVSTQCHPNNRKDFQARVATFTTMHWFAKPVELNLLTCARFGWINSGPDELTCKCCDQTLDCRIDPRLGSEGAQKVAEGLNAYLTSYHLDTCPWKHNPSPKSFTQVHFWTQEAALEAVLGSISNSYAKWASPSSSVALDTTFLDKLCEQWQVSKDDLKQISRQVAQKAVIDTSIDVVETKVDISALVSLAICGWQIIDGELGTFGCSSCNRVLRVISNNAQEPFQDEESTEPSTKRQKPSGQELCPLQEHRFCPWQRTTDDEMEYPGWVQCAKAIKHGILASLVPEDTQPSHSSPTAASYEPSSALAKVQALLDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X4C3</accession>
    <name>A0A6G0X4C3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_008606</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000106">
        <property type="protein sequence ID" value="KAF0734755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X4C3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018451"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.10.10:FF:000007">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF29">
        <property type="entry name" value="PEPTIDASE A2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="9">
        <location>
            <begin position="162"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0734755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="389" mass="43869" checksum="5854832AB9526C96" modified="2020-08-12" version="1">MPLPDVYADGTDDPVPPKPPDPNPVDSDNMPRNGDTVLTQQVYPGVIASVTDERLSSSRHGKDTRDEIPINWDGSSLDPLQRETIRKLLLEFDIFVTTSKAPGRTDRIKCTINTGNAAPIKSAPYRVSQREGELMEAEIRQYEDLGLIRPSTSPWASPVLMIRKPDGSIRFCIDYRKLNDVTIKDRYPMPRVDDLLDVLGKSMDVASGYWNVRMEEESIPKTAFVCKFGLYEWLVMPFGLCNAVPQFARLMEDVLRDQLWMSCLVYLDDVIVFSPDFATHISRLRDVLTCLQSAGFKLKMSKCHWGKTSVAFLGHIVTPAGILPNPEKVKSVLRVRPLRNVAEVRAFLGLAGYFRRFIQGFAAISRPLEKLKTTEVFNGHPNARMHSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X4F0</accession>
    <name>A0A6G0X4F0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Anoctamin transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_008734</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000109">
        <property type="protein sequence ID" value="KAF0734664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010107"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF73">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="555"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="947"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="994"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1064"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1091"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1146"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1190"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1244"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1298"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1333"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="6">
        <location>
            <begin position="936"/>
            <end position="1367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0734664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1556" mass="177732" checksum="D9B48E4257C58264" modified="2020-08-12" version="1">MEILTKIKLKQPCLVKGHTFAKWFQQEITMQRSAQKPWQYYFVMVFPNSAKIMHDELKSMVETTHKIQEREINYLIGIAAKHPRNNIPKPVNPFIAVFMTFLRRTNALSLLLLLALVGAVVYVKTASGYSIFLNAPVLIVFSLLVIIVGITPYLGWKGAKNKNWAYLRYYDSAIICFLALLALNVCGLEYFQANVGNALDLQQNHLFKIYGNPLLFSNQTTGQSRPVTSFLQAEVFKSFVNFLQARFEELFPKNELAGSTHRRLSSDIGAWFSQTFNVTAVFYPPPITETPEWMKTFVSTTCTDQPVVNGTFLTGNVEVIMEPTFQRCLRPILETCVYAASYTESVLVILAALLIIQYLSLLVLKYIDPAAAEPRKKSLRKTSSIMHFFDAVLFTLGVISIASGGYGIYNAVTRGEGKVLDTEMRVVEISSIVVAIVYGHLLCLSALLGCSQKLIPMQTYVLTGVLILQFALAVLMYNVKVDVEELASKSFQDQTWDESLVLLGINHVFTRIESATSEFVVDFVNHECQINVRSTKLTEQCRATLAIRITELLRWVINAAGVVMAMQCILLVRNLITTVVMPCLRRLWKKKKTKRGQGIPTVQISNEPTTKEATLPFHAAMDKYWESFPRGFANDKNLAQARQQFTLEWLKVTGATRVHEKDQLLAVSQFESIVRVLVLKRLVNKCGLEVSVNISRDGKHLYFKLAAPRKVIADEAEARKYHLQCRKAVDPCPKFWTAREVAIENTVYDTQTAKQKLCALYGRQLLTVVENQFFPNESMAQVSRRINVHNREAMYRDEETAKKKKLPTPSRYAPYFQYFRKPSMQYLYQRHSTQLDLPTTDVAPSVFQVTGCLKLLHLVIHDEFDTARMISNGILDGFSCLHSASRFEWTNITSLSTSWLTYWRPRHLPDEPDPDKHYFINFFYRIYPFRQPLIAVRSYFGEQIALYFHWLGFYAQCLMFPVVCSIVYVIDGGSYHSYNVQITDGHVECELKDMFLGLAVLIWAFVYAKCWQRKNYMCAIAWGMHGIEENEKDRVDFYGKEQLNPITNEVERTFPDYLRLELQLTSLASMAAIAVASYFVMVMLFPLEKPLVQALGPFWGVTAMSIILVLHIQVNSLNVTRVAHWLNERENYQTQSQYERFMIMKLFALQSMNHFSALFFIAFFKRSSFGCYDTVSLEATSNCLPEMENLLLVIFGWRLVFNAFRIVVPLAQMVWSSAAPQRYDIEYELSLEPYENTYEDYAEIVVQFGLMTLFIFPCPIGPIFAFFESAINLRMDAYKLCYCSRRPLPQNAEDIGAWFIYLLFLSRFCIATNLGFLFFTASNFASYSAQERWTFYLLSTAAGLLIYEALWFVIPTTPDKAATILERHEFLRQKYLFAHDKSSSTAPPTSQKKPSCAAMLETLETYNADALETLNARLDLLNKFNELFVTKPTAPGDSDMIEMTVPATLEPTTLTGMDAIREAVRRSAGLFGSDDENDDDESGKIPQFLSKLDDRNALEWYFTPQPIPEAPPLSHVPTNTSTLHVTRGFVEDVEVEEALDDDYIIQDDDEDLADLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X4H2</accession>
    <name>A0A6G0X4H2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RWD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_008505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000103">
        <property type="protein sequence ID" value="KAF0734841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X4H2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010382"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd24163">
        <property type="entry name" value="RWDD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017359">
        <property type="entry name" value="Phi-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010541">
        <property type="entry name" value="Prp3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059181">
        <property type="entry name" value="RWDD2A-B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15955">
        <property type="entry name" value="RWD DOMAIN CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15955:SF8">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06544">
        <property type="entry name" value="Prp3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RWD" evidence="1">
        <location>
            <begin position="19"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0734841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="276" mass="31322" checksum="1E3E443F5EE3FE26" modified="2020-08-12" version="1">MEDAPTYSMDIAHVQQVHDELECLQSMFPSEQELQVDPYVKILFESVALNTTDESVDLPLVHLTLFFQTCPIDNCTPELKISFPKDYPDEQLDVELVCPTLPRSNRQMILDALQQVAVGCVGEVCVLQIYQEALNLLEEVQNLQTPEAESTPSLPISIVPSVVGRRAIYFHHIIAPGKRQVVKDWAKELQLGGFSKIGWPGVIIAEGIEAYVHEYVKRLQHLRWKQMVVRGEQTDTTRRLPSTFFELTDMSELAARCNEAGLSELFLTTMKIYRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X4P5</accession>
    <name>A0A6G0X4P5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_008418</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000102">
        <property type="protein sequence ID" value="KAF0734941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X4P5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000150"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0734941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="124" mass="13587" checksum="82CF404F83590219" modified="2020-08-12" version="1">MDSTCFFKDCPNPVAAPGKLKCTFHAKKGICGAPDCHNQVYARGHCIRHGGRRPCRFEGCSGNARSRGYCTRHSSSANAEDDALALPDFDFDIDMNLVFDDVELEQNIIDALLVDSDFQAVTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X4S0</accession>
    <name>A0A6G0X4S0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_008534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000103">
        <property type="protein sequence ID" value="KAF0734872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X4S0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003404"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051707">
        <property type="entry name" value="PI-Interact_SigTrans_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336:SF8">
        <property type="entry name" value="PROTEIN OPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336">
        <property type="entry name" value="TANDEM PH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="4"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0734872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="143" mass="16402" checksum="C6402B3DA039C9FA" modified="2020-08-12" version="1">MTAPIHKRGLLFKKGSGQGLLNRQNWKLRVFELTRTELNYYDTNKSSTLKGSLDLTTCRVADLEIMPADCTKTGSSDSSEWRIAIQTPSRRFVFATATEDEMHEWATALRAIFAANERYLIHDDGDYDQSNTFINRYLERLAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X4V6</accession>
    <name>A0A6G0X4V6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_008540</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000103">
        <property type="protein sequence ID" value="KAF0734878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X4V6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003411"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF214">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="268"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="646"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0734878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="912" mass="103736" checksum="5653FF25CF87EA0A" modified="2020-08-12" version="1">MASVTSTQEAIESLEDVIKWGVRHIPAANPAHQSTLRIACAVMELCLKFRINKEDILTIGEMVARITRSIVFQRARQDEAFQLDNLATALANTHAYLDETLEATKGWNLLIDKTAREKMAKSITTHIAQYQEDIRRAASFLLVDFNIEIVGSVDDLMQDMQAMMDKLGKMDYYISLAQSNVTPNRQVDNLLEMAIQLQRGLDHYYHNINLRNVQANHTFEASVLASFDKVVHAAKDSWRASKLTQDLPLDEMIQEWTLASDDVVYDPNNESTFLGQGASAAVYLGQYKGRNVAVKHINTIKVADSAEFEASIRKEIKVWRDVANKPHILTLIGVCTKVASPIVVCEYCPDTITRYIRYRPEKLVEMVAIGLLSLHSAGIIHRDIKGSNVLVREDGTVAIADFGLSRSTESLLTQYSNARFVGTLNWMSPEQRFSPRKVTVQSDVWSFGMTVWQLMTGDLPYRDYCQEEIEEAIRSQDDRPGRPEDLRKDYEALWNLITWCWKLNPSNRPKAKDVVDFLENHYRQHLKLPSKSNSMVERKVAETIEWENNVEHKDLFELRSNIQTNKLLEYRSHDTTEISVDRQSIPTAAAIHDKATNASIRGSIPGVSEPILWQTSEEVSFDEFSSQSDEVSVIDLATIRINAQEIDLVRVVDHGLISEMWSGMYRGTHVTIKKLRQNNATPSKLKTFIQHIQLMATFDSPFIVQLVGAAWNHPRDLMCIMEWLDGGNLREYLNATTDEVFSWQAKYEIIHHLVEGLLYLHSMNVIHSDVKSRNVLLDSLKPAKLANVNTMEMSVEDTMIAQLATFRWMAPEVILDESYSSASDIYSFGVVLAELDTHRVPYRDIIHPESGERLTDTMIIEQVATGSLQPTFNSYCPEWILFMALQCLSYNPEDRPTALQLAEIVRANLMDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X693</accession>
    <name>A0A6G0X693_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_008001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000095">
        <property type="protein sequence ID" value="KAF0735521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X693"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002200"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="368"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0735521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="561" mass="64587" checksum="EC8C1C13A372F251" modified="2020-08-12" version="1">MVMSPWNNPTTLTRTWCVFEVYASVVENARFEIALGRSQKACFLQDFQNEGAFKQMLSTIQSEKSSTTVPSDRDNIFKLIRDEVGFAKLDRMVFEVIEKWMARTVHQQIDQAPCLEKKAAWLLVKADFLQEHGEFAASMETCQAAVNIYRQDLQDQSSDTWKAQTLLAALKFDEGHPREEWEPLLQESLVKQIRLLSKDHADTLATMHHLGHCYGSICEYDLGLSFLMECFERQRRVLGEENLQTRNTMSQIAVFLSEKGKLEEALEWNLRCFAIQRRILGDDHPETSRIRNNVGVAYTKLGDFASGAEHITACCEVYRRTLGPEHPKTLTIQANEGDSYRLLGDYTTAEKLLLDCLKHDHHFEHMKAHCLRYLGLVYLGMKDYNRAMSVYQEALDRLAAVHGRSHAYYTRALPAMFVIKMNSGCFELLEEIDTFETELDHASWTKDIWKDVSCHGCRSEIHGLLYHCSECPPQSLRFCQDCIALNKPATFCKHGADAIAFLKPPSRYLQEKRLDILAKKSDWQKYETHFVAYVNYCDENQIAKDERLTNQIPTEESSPDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X699</accession>
    <name>A0A6G0X699_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_008067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000096">
        <property type="protein sequence ID" value="KAF0735500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X699"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011259"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0735500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="587" mass="68406" checksum="15735FE965C34538" modified="2020-08-12" version="1">MARPHFFRVNCSHSELFRDSYIRCYQNNGLKIIRLQLDRKERLTSLFMARCFPHCCPHMEYRGCGASLSLQIDVIKSTEFGKLHAFGRFEVVAEPAIAEGELVDWTIFSSDLRSKKNAFGMWLQGHRQVDEPRAAVFHFNKSRTDGWHYKWHSGSSKQKRNELHRFHVYVVRRESDTECSIVLSAYSTPFSLSSYRRAPGNKFGHDTMPSEKTQRKLSKPQQNPHDRGLAEAEKIVRLFDICSKMLIDDVPPQQWAVLEETLHCRCVSWSGLNIQPTAMQIIPDRLRNYLQKPWTVANEIALKLLWIWFDKTTFEFCQQIFKEHSECENHRAAYVDSVEVFYDTFVVKNFKNNMDALEKILKNRRSQKSTSQADNKCYEAFVCAFRESAMDLINFEPHRAALGCNGLWHLQHVSMRNLDVRPSVYNFFRSFTMFFALNLRMKNNLLFVQSKLLMFPAPWSKFHLDGKAATFHNFPNGESCGLDQAAMVGDYKAWVEFGTIQLWIYRWPKANQEKCYLLRVWIAPCALDPNILRISWMVEEAATTISNFNALQAEDRMKVWDDMEHTLVLQADTVYSRVDSTNLAVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X6C7</accession>
    <name>A0A6G0X6C7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Reverse transcriptase RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_008019</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000095">
        <property type="protein sequence ID" value="KAF0735539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X6C7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021218"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase RNase H-like" evidence="8">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="150"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="150"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0735539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="213" mass="24790" checksum="BCAE93DFA450E6A4" modified="2020-08-12" version="1">MCLFTDASDTGWSIIVTQVLKFDKNVPIQDQQHEMLVCQSGMFTGAQLNWSVIEKEANPIARACDKLNYLLMRPDGFRMYCHHENLIQVFAPHSEWKTYQRQKLTRWAAIIGGYRYVIEHIKGTSNLWADLMSRWGQARPPARTMTIPHVRRGHGWTKKRKEKNKATSPPSQHRLRPLDDPEFVWPSSMTLRVHKRHISSPSRRKRTPTKACG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X782</accession>
    <name>A0A6G0X782_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Signal recognition particle subunit SRP72</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_007881</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SRP72 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000093">
        <property type="protein sequence ID" value="KAF0735879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X782"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003778"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026270">
        <property type="entry name" value="SRP72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031545">
        <property type="entry name" value="SRP72_TPR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094:SF9">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17004">
        <property type="entry name" value="SRP_TPR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038922">
        <property type="entry name" value="SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="597"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR038922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0735879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="623" mass="67677" checksum="B89F8EC12CCE1120" modified="2020-08-12" version="1">MATEVQALFTELHAALEQENYQKAVDLSNKIRAKAPNDADAIRVKCQSLLRLGKFDKALEVAAKVPELKVEQAYCLYKLQRVQDALNVISTFPEPKTKSVLHLEAQAHYRLNNYDACISIYEGLLSSAAATDDTTELKTNLLAVYVAAGRGSEIVRRSLDAEGSYEVAFNKSLAALQAKDNVGATEQLAQAEQLCRETLASEGYSPEEIEQEAKIIHVQEAYVAQLSGDNERALETYRQVAKSESDLGLVAVALNNIACVQKDSFDSLKRLRAISKEKCTPSQHQAILANTALLLSHMNKPDEARAVVASLAASAPHSPFLPPLLLHLESDLAALVETLKENKSPEGYLHLAHVYSVLGHPSKAADAIRQISAIQHTPGTVATLVALYNAAQDTKSAEQVTSAALQHASSSAVLLEGDGVAKLSKGQYADAAAAFTRLLDGGSDLEPESRVRCLAYLVIALSFVDPTQAVERAVTLPDVTPSDQPLQDLVKRAPRPKAAVVAALTPKEKKKRAENRERVLRKRAKRKALFIASLKAKPDYNPLIGLVNPDPERWIPRKQRSRRGRKNRNKFVGAQGAGMATQKDALKLDVAARAAAKKAAPATEKGVLVTDGPSMNRKARKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X796</accession>
    <name>A0A6G0X796_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ADP/ATP translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ADP,ATP carrier protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Ae201684_007769</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Catalyzes the exchange of ADP and ATP across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ADP(in) + ATP(out) = ADP(out) + ATP(in)</text>
            <dbReference type="Rhea" id="RHEA:34999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:35000"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 16">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000093">
        <property type="protein sequence ID" value="KAF0735764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X796"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014490"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140021">
        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000002">
        <property type="entry name" value="Putative ADP/ATP translocase 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635:SF14">
        <property type="entry name" value="ADP_ATP TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00927">
        <property type="entry name" value="ADPTRNSLCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="11 14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="26"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="128"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="229"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF0735764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="315" mass="35094" checksum="D0313168DC6D124C" modified="2020-08-12" version="1">MFARYSRLEPITTAPKNDKPKNDPVMSFMADLAAGGVAGTISKTVVAPIERVKLLLQVQAASTQIKDPYAGIINCFRRVAKEQGVASFWRGNLTNVIRYFPTQALNFAFKDIYKKLFLDGVKMEDFWRFFLGNLASGGAAGATSQFFVYPLDFARTRLSADVGVGKERQYEGLIHCMKSIAKTDGIPGLYRGFVVSVGGIIVYRAAYFGGYDTARDIIIADPKNAPLWQKWFVAQVVTTFAGLVSYPFDTVRRRIMMQAGRKDILYKSSLHFWQKIFEDEGPRAFFKGAGSNIIRGTGSAIVLVLYDEFKAIMGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X7D9</accession>
    <name>A0A6G0X7D9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Orc1-like AAA ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_007818</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000093">
        <property type="protein sequence ID" value="KAF0735813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002072"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052752">
        <property type="entry name" value="NACHT-WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19871">
        <property type="entry name" value="BETA TRANSDUCIN-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19871:SF14">
        <property type="entry name" value="DUF4062 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="3">
        <location>
            <begin position="39"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="351"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="437"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="548"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="855"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1436"/>
            <end position="1545"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1120"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1285"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="352"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="467"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="562"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1456"/>
            <end position="1466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1488"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1534"/>
            <end position="1545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0735813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1545" mass="173315" checksum="8603F9A5E3BF1733" modified="2020-08-12" version="1">MAKGRPPVDEIDSISEFESEFHHAFVKGRLAHDDFVFQASLLRELDEFCDVDSMHVPKGPLIVFGEPGSGKSAFLANWMNRRKKKFHNWNNGFPEFIFYHAVGCTRQGAFVSRLLERILTEMKEFFELAKDVPTLEERLSWQFPRYLDAASRKGRTILIVDGVHRLRTTDGDSILKWLPLSFPPNVRLILAATSPSSRHATVASDSDMLSTMERIKVEASRRNWTTVCIDPFTVEEARTVVHKFLARQINGTPTLQLFDLQQKAIASVPRATNAMFLKTLLIGLEWMAGRGYNIHAILRDWLVVSSISSLYEAILRSMEAGYTTSVSDTQDSMLFLQEHSLDATFAWMPQMTTRPSSSSSTSTLPTHRTSTPDRRSPPLDTEPYNSDDEMRTPRVMEETDANIPLLFRELAADATPLGQDSLESGPRPIVLSVFTSSKPPALGQEDDSADTLGGALSFQKKSPEGASSPPSLSDSPPRPSVVRPVERTKTMRTSSFPIYVTGGQNVLGLDGLLGKALCVLYVARHGLLLHELRTLMQAMTVDETRKKDMTAPEMDDDDDDNSSLNAILSDNGPSSRARAPAFSEETWTTLLSALRALGCLFLQDIVLLPHCNDALRELIWWRYIGSLKAEETYHHWLVRFFISHSATFRRVEELPWHLASCKRWLALKDILVNLPMFQLFFTATYKTELFSYWKMLTEGVYVSGSATPPPPPSSQCFTETQDNGGIVEPPAITTFDLVREYNKSIEEWYHTARPATKQLLPMLQTMTKFIFEYSVFSQSELPRFNHPALDLKALASSGFRFVDQLPHAIAQQALDPSLHWLYHRWVWVQFPWLALGHEIEDPKLAVSLISSSSSTSTQDVKATDQDPVEPGSPQPALTPGNSTPPPPNPANASLPSCQSMPNLTRKPPGPTISPYKLKGITNASLPTIAVANAPNTLDIIGPNSPTHVLMRRKTNFVGYKNAPTACFPAQIKSPPRLDDASLNSGVGKLLSQGSSASVPSSEGFGLPAHMQEYSKTEADIKRSCNQQILLKLQQSHNFLRREAYAKSARLEKLRQKIRERKAKQTSSLQYIQEAEEALGEMTKRMDQVDATLKLVGKQEKTYSKLLTACDDYPAIDSHHLNRVKKELQFLTLKLRDLQKERAALAFEQHHLATTEFPQLRAACDENKRLHDAVLDRLERTKQRMAHDQANIEELYKVRQAIIDRVKSTAFDLKTNDTIELDKLMSVQATAETIAANKSQVAKTALEQCQSMCRRIIHATGLANMAAIHEKFSNREALNRSLDEQAALYEARLKQIKMSHSELESQMRALENVPKDTQDPRQLEDLARDAEASLSRVQQTYATQLHALNEVLVGISNVARLVGITDVRCPKRGLVPAAELWPPYQDKESRAMTLSHFETVSANTLIDVIRVCEERMVVIIDNNEHGRGDPDALYAQSRRISRRDSSVGLSSSPRIGTGKRRPKKDKRRNNLEPISPREREDLNVDMDSAYSTPSSTTSQLDSPREDDTSAVVLTRENIKVSSKHKVSVKKKELTSRPNYEDSINSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X8S9</accession>
    <name>A0A6G0X8S9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_007406</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X8S9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021253"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026069027" description="EGF-like domain-containing protein" evidence="2">
        <location>
            <begin position="16"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0736387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="241" mass="24969" checksum="EFB84406D5F234C8" modified="2020-08-12" version="1">MKLASVLVATTALAAQTTNKPNATAKPNVTAETCKLQFLSPCKSDSQCGTLNGFNLTCIKSGSNMQCSCKGGAKKCQVGSTSDDVAYAFDACTESRRCVDGGGYKYLDDVALASGKPVCEEKLYCVQEQNNNTEGIVLTSQCLTCSSCRQMNTKSNSENGYARFDCDKICPTPPPTPAPTTTEAPETDAPTTRPSKLTTTASPTSTVSSGGTVPSGVAKSTAAASFMVGVVSVMAFALSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XA52</accession>
    <name>A0A6G0XA52_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_006813</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000085">
        <property type="protein sequence ID" value="KAF0737002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XA52"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019675"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0737002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="81" mass="9092" checksum="C31D79B652D8622F" modified="2020-08-12" version="1">MCRSQSTETVRFDHISSEDAIGFTFFKSKTKQEGETIKDPKHCYANPFKPSVCLFVALGVYLACNSQIPSENLFPGSRQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XAB4</accession>
    <name>A0A6G0XAB4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_006837</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000085">
        <property type="protein sequence ID" value="KAF0737027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XAB4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015975"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0737027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="188" mass="21115" checksum="BA42FDFB44FBA00E" modified="2020-08-12" version="1">MTSTNAWGTIAMPPSVTLRSIMDETLSLKQSESQDQGRAVLHSMEERASDTSPDVSADFAFALALQLSEQMSAHTIDYAKLASTYDQTLQVMQPVRRVTERKTPSAVRPKLCALEVEEYVPSQRQPQRRKKPKKTSPEAKRSSYVYVPRIDEDEEDVLEVGIASLFFSPTEFFADVCSELPFCDSEIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XAE3</accession>
    <name>A0A6G0XAE3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_006771</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000085">
        <property type="protein sequence ID" value="KAF0736959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XAE3"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0736959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="91" mass="10163" checksum="A82B90C763BD882F" modified="2020-08-12" version="1">MFLLRSVHGDLVIMKHTSRLDDSTGCTQLLSCKDCRGQRDETFARTRKTTNVTLTSRDTLIAQAKAVIALLSWRGWRSVGSTASTLDRTFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XB29</accession>
    <name>A0A6G0XB29_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_006516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XB29"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000973"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36970:SF1">
        <property type="entry name" value="BESTROPHIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36970">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0737347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="385" mass="42995" checksum="570C129E99599799" modified="2020-08-12" version="1">MAPSRHDKLLEEEEEALDHSDWTRDPLLAEAYVGFNELVIPSTQATFPDASAGLLRGGGWNALMTHCYASLLDIAVAMYVFWFHLLTLETVLVVIMAAASPSAYYFIGFHASGSYFGANLSWTLVTFAIVSPMIMQIRQAFTRREAALDAIAEMKAITANVLMANAIWDWGKNERSKLPADHVIKTKSYLVGVLNDLEELLTLPTFTRGRHQFTTAGISSAKGHVHRFHYLGRRIAYTITLLHRQVEVMKFLGLPANEASRINQYHWFIQARIEKLCNIKLYRTPQATRSFTRLCILALPLFYGPYYVYIAAAGTNGVHTNFAFALTLSIATSLIMIGIFNVEMALEDPFTEQGLDGVKVHRAIARILDTLDVILPNTATTTSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XDA2</accession>
    <name>A0A6G0XDA2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_006101</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0738114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XDA2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003345"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="161"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="119"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0738114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="337" mass="38206" checksum="77991787DAEE2227" modified="2020-08-12" version="1">MLQLLEKNPSSQPALEKLTQLAEDRKEARVVEKLEQESKEVVRRCEESYRAGFMKCVATELARIGAPSMITWQRLVHDKDCNYQAIRILLTKIKSSQKKRSMTLPVIELKPREALPLQRSPSQDSTLEQQTLPRRSISADNRPAWNNDFIEDPSSFVESSSFSRLKRLPPTPQTQVFKPEEPSQAPTTTKNNDAKLKAITKENASLKKELQELQAMHDAFVREETEASGREGFARRSRFLQAQNLQLQRQVDMLLEAVALRHQTADDLDAVVASLQKIVEKGRAEAKDAGAVQDQNIAWMMAIPTSLLAELNQVSSRLKQIKYRCSMEAPLRQKDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XDR3</accession>
    <name>A0A6G0XDR3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_005806</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000076">
        <property type="protein sequence ID" value="KAF0738370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XDR3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009289"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827:SF1">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0738370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="203" mass="21999" checksum="74682AA91163CC90" modified="2020-08-12" version="1">MIDFLFDDIAFLDHEMLDLTDVPEIQLDDILDDIQSDLLLNHEELAFLQGLFRTDAMTLTTTIAPTTSMIAPANTPRRSRKACSIPGCFSFARCRGLCTQHGGRHLCSEENCSRVAQYGGKCTAHGGIRPCTVAGCIRSVQSHGKCKTHGGGTRCKVAGCTKGSISNGRCRGHGGGKRCQAAPCTKWAQTDGYCTRHHRDLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XGK3</accession>
    <name>A0A6G0XGK3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_004961</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000064">
        <property type="protein sequence ID" value="KAF0739392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XGK3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016170"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF8">
        <property type="entry name" value="BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="58"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="91"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="124"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="157"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="190"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0739392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="240" mass="25392" checksum="07F224981FCB6727" modified="2020-08-12" version="1">MSKNKAAALTKHEMPEVDTNPFKLAAVGNLQILKTLVEPSKEGGNQGKTIDINAKDIYGCTPMIWAARNGYYEVFEYLITQGADIETTSFGGFTALHHAVNHCRLNVVSKLIELGASIDVKDDSGNTPLHIGAGRGILNPVLSLLAAGANINETNAQGVTPLHKAVSAGHFPCVEKLLENRADPNIANSEGNTSLHLAAKGGFDNIVHVLLGTKANVGLKNKAGKTAKDVALTPEIAKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XH67</accession>
    <name>A0A6G0XH67_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_004726</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000063">
        <property type="protein sequence ID" value="KAF0739544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XH67"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001964"/>
    <dbReference type="OrthoDB" id="203613at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="149"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="35"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="161"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0739544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="227" mass="26652" checksum="AF43AB56D13C3CF7" modified="2020-08-12" version="1">MSMLATDKSAKWQSHEMESNVPLFERERRQDSQFVLRLQNELAETKRLLEVQTRQQNEMVRINEDLERRLENEACERINLDALKADDEKKWAMERARFEEEMKAWEKKLDDEVKRRAIVEERLRRAEKELYRMHQKKYDIEKAVRREESEKRKHEVYIKDSLTNRSSMSSSRPASSIGPSSLPSYLSIPPPNTANAGPASLLNPRDSKPATVRQRQALSSAMDFFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XHJ9</accession>
    <name>A0A6G0XHJ9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_004686</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="8"/>
    <dbReference type="EMBL" id="VJMJ01000062">
        <property type="protein sequence ID" value="KAF0739800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XHJ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005128"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013235">
        <property type="entry name" value="PPP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051134">
        <property type="entry name" value="PPP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08321">
        <property type="entry name" value="PPP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="604"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="640"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="746"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="773"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="834"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="874"/>
            <end position="909"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0739800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="912" mass="102550" checksum="789F4C0EAF6C403B" modified="2020-08-12" version="1">MSVDDEHGEVAVGLPVLVFGKHAGVVKYVPETRSALIGVELNRPMGDCDGISDDGQQHFKCRPLHGIYVREENLKPYTAEDAAAVIIQSVWRRRKTVIAFTTVVLSTMWNMLDNNQEQLNMKRAEKTKSASQALTLLAKQSSKDSGFKISHSVSSVTDDYSGPRLEFPLRLHNVLDMLEQFKKGTILHSKYVMEVLTEAKKVFAPLPTLQEISVGENEKLTVVGDIHGQLKDLFTIFTTNGLPSTKNKYLFNGDFVDRGAYGVEVMMTLLCFKLLYPEGVYLNRGNHESRNQNSWMGFEEEVWAKYDGTLEGDPCRASVVYDSFQAFFDSLPLCALVLKKIFVVHGGLFSCDNVTLAHIKAINRKREPPLHQSGFEDKIFEDMLWSDPRTIAGRQPSERGAGTEFGHEVTNNFCAVNRVALVIRSHECVPEGYDVLHGGRLITLFSASRYCGTQMNKGAFLTLGSDLQPEIQQFYGNPLNESEWEAPEDEQAKLQENLEGDALRMIAERICDHKADLFWYFTQHENESKGTVPRLVWAEALKSILGMDLPFLLYQTKLADIEPDNSINYSKFLSRYRIENPAVDTSGWQESIISTICKKLYRAMGAGSIEQAFKVFDTDDSGTIEYDEFMNILQKMDTGLSDQQMFELMRTADTNDDGRLDFKEFVSRFEVIFTDVRQANSQSFLSAPPAPVQSLSAPSKLVRKTSERAASLTPAPKQDLDEETMAALVAIGKAFFALDGSLLDNFHRFDTNRDGVLQKEEFFEALTGLGLNYSPELLEKIMGAVDLDGGNTIDYKEFLAAFTVKDANEQAALEKGDMTWQQSVLQQVSNMFYQHRIHIRAAFRIFDSDNSGQISMEEFRAGISTFNAIMDNPLTEDQIDALLAHLDSDGDGKISYKEFLEGFQVVDVRLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XHL1</accession>
    <name>A0A6G0XHL1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Knr4/Smi1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_004852</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000063">
        <property type="protein sequence ID" value="KAF0739684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XHL1"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039231">
        <property type="entry name" value="TPGS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31854">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31854:SF2">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0739684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="22288" checksum="19D4DF7825AFBA0B" modified="2020-08-12" version="1">MDELNALSLRVFEYLGSLPTVSNVDYKPSPGIQGHNVALWEQRHKPKILPHDLVEFLTMSNGLSVKWYTMLKGKQHLVGHFSLNSLQQLKDMNAVFPDGTHLALALHSSITIEQPEIWLHDTMSNWVFLASTFTDYYRMMIVHLGLIGWQNLYTSVGLDPLTKQWFYLFVPGRVRQLPLNSKAAETPKIAILPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XHV3</accession>
    <name>A0A6G0XHV3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein transport protein Sec61 subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_004620</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Necessary for protein translocation in the endoplasmic reticulum.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SEC61-beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000060">
        <property type="protein sequence ID" value="KAF0739846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XHV3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010297"/>
    <dbReference type="OrthoDB" id="5401193at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005784">
        <property type="term" value="C:Sec61 translocon complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030671">
        <property type="entry name" value="Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016482">
        <property type="entry name" value="SecG/Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13509">
        <property type="entry name" value="SEC61 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03911">
        <property type="entry name" value="Sec61_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006398">
        <property type="entry name" value="Sec61_beta_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0739846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="89" mass="8956" checksum="0363B2C3AB3F5606" modified="2020-08-12" version="1">MARTAGDASPSQGAAAPPSGGAAALRNRRPAAGKSANNGRGMGGSSAGVLRFYTDDAPGLKIGPTTVLVLCLMFVGFVVLLHVWGKFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XI07</accession>
    <name>A0A6G0XI07_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_004888</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000063">
        <property type="protein sequence ID" value="KAF0739721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XI07"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018183"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030429">
        <property type="term" value="F:kynureninase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010111">
        <property type="entry name" value="Kynureninase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084">
        <property type="entry name" value="KYNURENINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084:SF0">
        <property type="entry name" value="KYNURENINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22580">
        <property type="entry name" value="KYNU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0739721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="298" mass="32255" checksum="B7D1A923C14159A0" modified="2020-08-12" version="1">MVVLDINNFPSDLYIAQSVLAAHGLTLQLISADNIPSHLNDSVAAMLFTPVDYRTGRLLDMAKLTAAAHDHNILTIWDLAHSAGAHEIDVHAIDADFVLGCGYKFLNGGPGAPSFVWVHPRLVNRAAQPLAGWFSHANPFSFTGEYVPAEGIQRYACGTPSILAMAALECGVDTVLASAPFGGMQALRAKSIELSQLFIDCVDQYCDGFDLELVTPREAALRGSQVSLRHPTHGYAIVQALIARGIIGDFRAPDIIRLGFTPLYTRFVDVYDAAIALAEVLTSGEYKDPKFEVRNTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XL00</accession>
    <name>A0A6G0XL00_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_003584</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000041">
        <property type="protein sequence ID" value="KAF0741012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XL00"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018535"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF18">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="25"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0741012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="343" mass="36387" checksum="8D35BE9AA51778D9" modified="2020-08-12" version="1">MATAVPTKMRALFLVKKVASFTQEDINSCFEVREVDVPQLKEGEALVKVECSPINPSNLSIITGSYNSAAQSPLPTTLGTEGSGTVVATNGPAVKVGQRVGIFLQKGIWAEYVVVNGAECVPLPDDVSFEGGSSIFVNPLTVVSFVEIALERGVKTIVHTAGASALGKMLVQHAKDRGVQVIAVVRRPEQVQALQAVGAEHIIDTSDAEWKGKFKELAKSLEATLAFDAVAGSLVGELLANMPNGSEVQVYGGLSGQAVSGVSPLGFIFEDKKVSGFWLVKYLGKKDPAGKFAMIKQVVAGLNTSFKTTINKSYPLEQAVAAFHDYIANMSDNKIAFKPSQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XL18</accession>
    <name>A0A6G0XL18_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase class V domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_003686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000041">
        <property type="protein sequence ID" value="KAF0741121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XL18"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007237"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43686:SF1">
        <property type="entry name" value="AMINOTRAN_5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43686">
        <property type="entry name" value="SULFURTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="1">
        <location>
            <begin position="76"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0741121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="657" mass="72659" checksum="EBEFDA8B144B567B" modified="2020-08-12" version="1">MPLTFECLVPKLAAAGHEHSTQISQDKTCKGNVNYVPAPTTTMNDDSGKALLQYLRSNIIGKNMTFTTPFGSRPLVYVDYTASGRSLQCIEDYIQTQVMPFYGNTHTTTSITGLQSTAFREEARGLIAEAVKAAKHKDAVIFTGSGSTGAVHKLVHILGLHLPHPKMSKRPVVFVGPFEHHSNLLPWRESHCDVVQIHESDQGLVDMAHLTQMLKKYAGRPLKIGSFSAASNVTGIVSDVNAIASLLHTHGALAFFDYASCAPYVDMDMNAGSLSYKDAIFFSGHKFLGGPGSPGVLVVKKKLFMTDVPTTPGGGTVLYVTQNDHYYVNHIEEREEGGTPDIIGSIRLGMAFQIKQRTGTTTIMQCERANLSKVMKALDGIPQVVVLGRCQNVDKLPIISFLIRSGDRFLHYNFVGALLNDLFGIQSRGGCACAGPYGHRLLGISKAHTAKLNAALLENFHVLKPGFTRVSFPYILSDAEVEYVVEAIKFVARHGWKFLWQYEFRRETGEWFHTSLHLNKVETPQLRGFFTTSLSLPNAVEACKSTYKLYLDKAHALARVALCHFFCLPNPLPSSKDQLRWFLYPWDIVSFIQRDGNHVYLACHAIVGPVNPSLYCQLPSQSRTIGQNLWGRLALHVFSSVRSPARGSHNSHQLGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XLC3</accession>
    <name>A0A6G0XLC3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_003730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000041">
        <property type="protein sequence ID" value="KAF0741169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XLC3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008461"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0741169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="596" mass="66589" checksum="85D0E5572D3B386A" modified="2020-08-12" version="1">MHMDVGFFINQIDEDRALRAVLHDHRNEGIDEGLADLVQLTANTNSRQLIWGLASLSAIPILENKPFKIPVKDGTQTFTMHATSAMDGFFLDILGFDAHREAKSHLWEVLHAAVRRLSPAYTRTRCRSPPMFKSNCRLIVEIILLGKCYRVYGKDWYNHRKQTQRLDLDILAREKKIPIPGSKPAQTSNNTRQTQDGKRQRVEPEPDLPWELVRKGAKQGTTDDPLPWVSPNMYQSLDERVIVSTKQVANAAGTDITILPVIFERPDAPTSTPQDAFVSGTKPHRNKAVRTKTSLNTTLDELAALDTAVAEAQASFENACVIAASKTKMKLAQYIQAGEADWIQRDLEDHPIVFRRQLRDLAVSSPHLLLPVVQLRLINRWLRASQGATLPFPKLYTETFGHSFSLENLQTDFTLLDDASQLDASSTPPNESSGDTTPIEVEIILAMAELILGSTAPMVYSSDTALYSLTAQPVFAIPSRFQSRYLASASIRHALWGTTMLGSTVWDELRKILTVAVEALNPDKAPADPALSLELAKMRSIFTRWLDVMQVMELAEEIDALNIEPTNQVMVDATSRRLVHGDLTELWFDFTPTSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XLM9</accession>
    <name>A0A6G0XLM9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Choline transporter-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_003540</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Choline transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000038">
        <property type="protein sequence ID" value="KAF0741251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XLM9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015718"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF14">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="429"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="482"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="519"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="580"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="614"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0741251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="682" mass="74335" checksum="9918BBA0B47A73ED" modified="2020-08-12" version="1">MFTRSNRSSSSSMPGWMNSPTGETPPSSKNGGKTAGRGHSSSFGDPSQPSWLVDSTPRHAPSSSVSWKGSGEADPLLPRKDTYVDIGLTRRQFKGPMGKRFGSDMLFLIFFAVYLVGMLALGIVAFVQDGLSDKVIYLTEGVDFQGHGCGATGAVYFPVYQTNPDFGLCVAECPVGGETITATVPLAPSGNASVDANVTTQIVPFTAYNTTKRGFVCAPIDSIDAVSADTTQLNDVLGLYIGAIRLNWEPILYSCGIGMGLATVYLILLRFGGCFVLSLSVIAIQVGLIAGAVYLWILSTKEDIHPDRATQNFFLISAVFVVCGAMAYFLAVVMMVQRLLLAGKFISFGTKVFAQMNKMLLIPVFYTVLLILALAWGLAVTVCIFTAGKSVQSEETIHVPNGDDLNILVHTFDRDVTMRWFFLYHVFGMYWLVSVLLALVDMSVAMSVAAWYFTPTDRQTKKKTFEVSDPVQYSMQSILQHHVGTAAFSALVVAPVRYIRNLFMYIDDNKDAEATGNLFAQMFSTLCCCCIWCFNQFIVFICKESYFITAIEGTSFYSAAKVAHALITSHLLRVGAINRIGNASVLLGKVIVCASTTAISWYLMDDSSSLSKVLVPIIIIVLISYAIAHTFMTLYETTINVLLLSFALDESLNGGRGHGEFADADLTKAVNDNLRPKWQTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XM66</accession>
    <name>A0A6G0XM66_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha 1,4-glycosyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_003169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000036">
        <property type="protein sequence ID" value="KAF0741484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XM66"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013009"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF1">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0741484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="36464" checksum="623D3F79B90DDBF6" modified="2020-08-12" version="1">MATSIDVIFSYRFLVVFVAVLFLAAGYFDVANIHSAVHQHMALVQDKVSYFATGSQHNYHRQESAFDEVCRVQFVFAGAKYNYNQFPTLQSWIRFADPTCPIEFLRTNHPFLGLLNIAEARMFHELAFLPILQADMLKLLAVYYLGGVVVDLDVEARKRFPQDWTGVDTPLASCDVVLGMEASCDTDECLKMFVRKGQIQNWAMYSRRPQSQFFGEMFDFIVAKYESMAPLNKGVSVQEVAGSGPITDFVQQYGNFSRPHYLVEISRNGGSLQSDTTNIMRIRKQHEEICIVGRSYTGGGCAKQPQCLLFHHFEGSWRRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XM77</accession>
    <name>A0A6G0XM77_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_003168</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAUS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000036">
        <property type="protein sequence ID" value="KAF0741483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XM77"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004506"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070652">
        <property type="term" value="C:HAUS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026243">
        <property type="entry name" value="HAUS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31570">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31570:SF1">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25762">
        <property type="entry name" value="HAUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="32"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="134"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0741483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="193" mass="22424" checksum="71F57A035B6B45CD" modified="2020-08-12" version="1">MELGRRYLDILTQSALVLNLDQVDTTAFIAAIEDLNERREVVDHDVAALRRELEAIQQQNDRARHELDHITHVHHSMRLMAEEREITENSLMFQHWARDYDEKEMLYRDEIAKCNAVLASRRFPLDESLEHHTLVNLAQQCAKLEAENKLLQDQLDETISLPSDVQEARLALEQAEMELQQLEELLSSATSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XMH7</accession>
    <name>A0A6G0XMH7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine protease</fullName>
            <ecNumber evidence="7">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_003264</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="7"/>
    <dbReference type="EMBL" id="VJMJ01000036">
        <property type="protein sequence ID" value="KAF0741583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XMH7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003285"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008256">
        <property type="entry name" value="Peptidase_S1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36234">
        <property type="entry name" value="LYSYL ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36234:SF5">
        <property type="entry name" value="LYSYL ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13365">
        <property type="entry name" value="Trypsin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00839">
        <property type="entry name" value="V8PROTEASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026376859" description="Serine protease" evidence="7">
        <location>
            <begin position="17"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0741583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="635" mass="67564" checksum="0D88A3B0E90202D2" modified="2020-08-12" version="1">MRLLFLAAAVFGLSSGLHVVPLNASQYSYVLPSYHDRCNPLDLADFTKPVWQSPPVFQTDAVYISLSISTLHLPLGAYVVARTLTNETTNISTLLPSGGTPYSAASAPRVYANFILVELHATPTTVFCANHTLRLDAFSYTTAADLAAMTQTLGRREQICGADDSVHAVCRYDPSNIGTSMFTFSRPVVRITVGPNNPDGSELCTGWLFGSDGDVLTNNHCIATQAQAASAQFEFIADSTACNGALTTTCPGVVEAITSKLIMTNAALDYSLVRLNASLVAKYGYLQASRTPTFVGQPVYVPQHPRGGCKLVSYITDAATKKPVVITRLDAPPGCGKGGVSYNADTDGGSSGSPVISATDNTVVALHYCGAVGCNNSGIPILSIVADLNLRGLLPSNAVASTSGAPAMPSYSDPRVVASSQQPVFGPRIVFDGIIRRTSNSTKLFPTSVDQYEFTLDAPGLVMVDILSYEIDEVASVYVDLNRDCRFNFFDSNIYIFSRDPNVPTYKPYFNDDVDRVLHATDGKADGSVSTKDSYLLATLPKGSHVVAIGITNLAIADAMKGQNNYKYASLESCVGDNTAKGAEGTYRLTLSSTVGINVTKWPTPIPTTPICTTPIAILQAKCAAELQAAWGSFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XN83</accession>
    <name>A0A6G0XN83_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Myb-like DNA-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_003341</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000036">
        <property type="protein sequence ID" value="KAF0741668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XN83"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017659"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000010">
        <property type="entry name" value="Transcriptional activator Myb isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050560">
        <property type="entry name" value="MYB_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614">
        <property type="entry name" value="MYB PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614:SF232">
        <property type="entry name" value="TRANSCRIPTION FACTOR MYB3R-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Myb-like" evidence="4">
        <location>
            <begin position="229"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="5">
        <location>
            <begin position="234"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="4">
        <location>
            <begin position="281"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="5">
        <location>
            <begin position="285"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="212"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="335"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="414"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="351"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="445"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="467"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0741668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="540" mass="61577" checksum="C5F4CF78F83562D3" modified="2020-08-12" version="1">MYTQNQLSPRENQRQSQSQSYNTGQQMDRQMHDQYHGQDHSKGQPAASEPQNAMSGQPGHAMLGHVSNNQTQAQDRAPDHGQGQMQGLMHDIQNQFQMQSQMHNQMQGHSHGDIQRQMHEQMQEQMQRQMQSQMPPSMHGQMQGQSPYHAMVHPHIPGQIPGQMALQLKNQRRHHMGGHDKALDNMRLPMATHDMGMMEADDLEMEQRLHSGLDYDDDDDDDEGKKGKNDANSKKPWTREENEKLMQLVKQYGAKRWSLIAMHLPGRVGKQCRERWHNHLNPAVRKDAWTAEEDYVIFECHKNVGNQWAEISKMLPGRTDNAIKNRYYSTMRRMQRQSLRKKGCSRDSKPRSQSMVTSPTSGDNRHMFQRGKQFQKLVLSSHGDKLDSTFLSDYDQVQRQHGMEFGAPSFNAGGFPGDYQSAPGGFSYDGPLRRHSSPADGSHLNLYSHQMQLSPTATGMGMTPYDNQRDNSDGDEKHALHDSHEPLDDNQSSKPRQSVNSRLFAIALPIQVNPGTSGVTTEQRDIKAFDPISETHEVYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XQ61</accession>
    <name>A0A6G0XQ61_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enoyl-CoA hydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_002630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000027">
        <property type="protein sequence ID" value="KAF0742539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XQ61"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001254"/>
    <dbReference type="OrthoDB" id="2139957at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF173">
        <property type="entry name" value="3-HYDROXYBUTYRYL-COA DEHYDRATASE-LIKE PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0742539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="413" mass="45593" checksum="FC055A4588CDABDE" modified="2020-08-12" version="1">MAREGTTPTRPKTPSQEARLVWKPDYEVKFGLVPLEGDFHNHIITKASCGFCDRYGREGKSVGSLHESESASGMFSESKRRRVGCKIWEAFRTDHIKRHLETEHPQKWAEYQNLSTDAKTHFFSQNPINATSDSESIDLQRLPFQRIPCVTLEKMGDIAILKLNDPTRLNALTSEVGIRLEELVREITDRVDEFVAVVLTGEGRVFSAGGDVAFLQARAEDTATRNSAIMRAYYERFLSLRKLPIPLVAALNGAALGEGMCISLFADARVIARDAKVGFTFVNLGLHPGMAVTHFLPKLIGFEKASHLLLSGKVISGEEALQFGLATKIVDKEDVLKAALALAEELTAGSSVATRTLLRTLRMHQDQGVELALAREVDCQATSFASADYQEGVAAVAEKRKPSFLASEHYNET</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XQM9</accession>
    <name>A0A6G0XQM9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Hexose transporter 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ae201684_002427</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-fructose(out) = D-fructose(in)</text>
            <dbReference type="Rhea" id="RHEA:60372"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:60373"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>D-galactose(in) = D-galactose(out)</text>
            <dbReference type="Rhea" id="RHEA:34915"/>
            <dbReference type="ChEBI" id="CHEBI:4139"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="7">
            <dbReference type="Rhea" id="RHEA:34917"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-glucosamine(out) = D-glucosamine(in)</text>
            <dbReference type="Rhea" id="RHEA:78423"/>
            <dbReference type="ChEBI" id="CHEBI:58723"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:78424"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-glucose(out) = D-glucose(in)</text>
            <dbReference type="Rhea" id="RHEA:60376"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:60377"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-mannose(out) = D-mannose(in)</text>
            <dbReference type="Rhea" id="RHEA:78391"/>
            <dbReference type="ChEBI" id="CHEBI:4208"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:78392"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-xylose(out) = D-xylose(in)</text>
            <dbReference type="Rhea" id="RHEA:78427"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:78428"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000025">
        <property type="protein sequence ID" value="KAF0742727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XQM9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002275"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000129">
        <property type="entry name" value="Major Facilitator Superfamily (MFS)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="382"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="419"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="16">
        <location>
            <begin position="23"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF0742727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="501" mass="54436" checksum="6AC801BCD08BC9E8" modified="2020-08-12" version="1">MDQAAAAASVSLQQGSKWYAVFVCVFASLGGLYFGYDLGASGGVLVMSSFLTHFCVGYGGNRYEACAASTLPQNWVDFTTTYMVVYYVGCMVGAYLGGVIADKRGRRAAIFSAALLYCIGNVILLVTGKGNHAMALLARVIQGLGVGNSSFSMPLFGAEMAPKELRGMLSGFMSMSVTTGTLTAGLIGYGLQDWANGWRTTVSVATIFPVVLMLGIFTLPESPRWLYQYKGRQAAEASLARLRRTDDVGDELKTIGDVIDQVGTEEASWKDVFDPSVRRRVLIAMALQALQQMTGVTIIFAYGAQIFNDVLGNGIIALLIFQATGFLTTIPTMYWVDKVGRRKLLLYGGFGMILSHLMTGILSSIGCHTDSDGLRCSKGAGWAMIIATAFFVFCFSISWGPITWIYPAEIFPLKVRARAVSLSSFSNWAMVAVMIVAPKLIPYLHVNGTFFLFAGLCIGGNTFVYFFCPETKNLALEDIERLFSAHRSLDVDIQTPAEDRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XSH7</accession>
    <name>A0A6G0XSH7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tetratricopeptide repeat protein 29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_001710</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000013">
        <property type="protein sequence ID" value="KAF0743562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XSH7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012667"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051476">
        <property type="entry name" value="Bac_ResReg_Asp_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46630">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46630:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="164"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0743562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="289" mass="32804" checksum="6916611CD076AE50" modified="2020-08-12" version="1">MVQTTRNYRAIWDFSDVAATEQRFSALLTPDTPLVDALCIQTQIARTYGLRDRFDEALSLLDKIDEQTATLPNPTDVDAIEVKVRSRMERGRALRSSKRAQEAKPHFLEATTLAEKAHMDELAIDAMHMVALVMEDPKESLSWSEKALQLALASEDPEARKWDASLANNIGWTYHDAGDFTQAMHYFKTALAARERLGAPKQIHIAKWMIARTHRSLKEYAQALEILHALENGSTEEDGYVSEELAENYEALNEHDKAKPYFLQAYTQLKDDKSLEPARLERLLTLSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XST7</accession>
    <name>A0A6G0XST7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_001354</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XST7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020887"/>
    <dbReference type="OrthoDB" id="59118at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF288">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="103"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="405"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0743695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="481" mass="53611" checksum="D1D9DE21F9A7242E" modified="2020-08-12" version="1">MEKLTSPNKLMSPTATWKRQKKFTPTRPLIASPSPMKTRRRRQCEVSLVLSPARDTVAKKLRLDSTTPTTEHEDNDGEDVVVGFTSSSKIEDVGLFNCDRDVQFTGGLYGEGTDGKVSACIIQGQKIALKRSKPHDGFTVDQAKRKSAVELHYLRRVRHKPGFIQCLGMCDGIEHTCIALEVMDCKLSDYQRKRMGAKQPFPAPLAHRIIKQIAGAMMILHEEVDAAHGDLACRNILVRMPPRGLEDTIDPEIKLSDFGRIKTRDQEPPILRSTFSFHKNADVGSFGRDVLYRLLVGDVLPAQSLESRSLHRLLQDSVVKSIPDGAAELLGPYHTLFQKCTAWGVRPTFRMIYDNLESLDFFETFENGLFPLKPNLTHLSTPTPQASGGSNTFSTPDIKRSLKLQLNSSSRSVSRRHEPVTSPPKPPIDPATAATTVESKVNWLKPRPVASTAPVKQTNPGASRRSLKILSEISKQRYLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XT62</accession>
    <name>A0A6G0XT62_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RxLR effector protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_001757</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000013">
        <property type="protein sequence ID" value="KAF0743616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XT62"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019346"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026081857" description="RxLR effector protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0743616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="105" mass="11893" checksum="5DAD4AF12F7E10FB" modified="2020-08-12" version="1">MRIALFLAVLVAIFATAEANPRRRWQEMASAALAQKAKQTPTWLRAAREFRNNLGQGEAEDRLERKVPPVRQGSLPRQRSYSAHQKPAPQTAIQKMASQRRNGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XTQ0</accession>
    <name>A0A6G0XTQ0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_001450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XTQ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002689"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="93"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0743802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="356" mass="41213" checksum="7EB424CF60B83F78" modified="2020-08-12" version="1">MGQNLSADATEIVHFRKMVKHTYYNNVAKLEKHTLEASLGFQISRASFLELCNRTEGRIAAIADTRQREAKMAKHVDEKMEFFAAVEEGKIVLGDTLLHLAARLDHVDVIEFLLEKGLHENVPNFHGHFAHQVCLHPSIQMLMDDVVLVHDVLGFDYDDEAKAHRIVRNLRRLWPLWMFDSSEAAHLVKVVGDVRSSHPFLNIYIKIANAMADRYRFRVTMTCLPIAIELLQQNEIKAYEAKRAFQAWPTPDKLQLVWDVLTTHFPKWTHVHDVEKDVAYLQFIQDAMAAWITVADDFRLYYKDEAAKNMPTPDTLQNYERQIWKSRLGPSQDEVEDLCAHIDGVQRYTRLSHLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XTW6</accession>
    <name>A0A6G0XTW6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_001529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XTW6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012887"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0743886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="408" mass="46095" checksum="C14B213FFA7FD5F8" modified="2020-08-12" version="1">MTLETPVPDNFFNPPPLSPGKIEELRAIGHRAKRDVLEYSKLTGGPVEWTLRNNDAKTQIYSAREGNVPLFLGVTELETTLDEARAIFTAVTTSDARRVNAAYLPDIQDEVRLYTLSTPTKDRPHHFCFVSWIHHRSPLQGRIVRHRDLRTVQHLEDIEMDGKKAWLGAYKSVVLPACPDFQKKYGVIRAEFIHFGFLYMETDRPGILREWRHDTWYAMNAMQNNIYAHRLSRVSYVASASYVNKYSRSNATCASKSVVHFLGGPIVDGAVRWFAKVCSAKYKVMMSNVLIDIRVCSHCIPGPNEADNKTRLSALNKTQQDGVSVLSGSSNPSFVKKSQLLENLSRWTEPVTLSSYSGDDMDRSMVLLDLDGYNYPIEPNPRGNQALTYGEFSNGSSARRRGDMVLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XTY2</accession>
    <name>A0A6G0XTY2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_001620</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XTY2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000797"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047134">
        <property type="term" value="F:protein-disulfide reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045108">
        <property type="entry name" value="TXNDC17-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010357">
        <property type="entry name" value="TXNDC17_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12452">
        <property type="entry name" value="42-9-9 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12452:SF0">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06110">
        <property type="entry name" value="TXD17-like_Trx"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="80"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="214"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0743980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="337" mass="38003" checksum="F5A6FB29CA477B78" modified="2020-08-12" version="1">MTKEGGTSSATASSGMSTFRVFQITMALLLFSTVAYIAKFTTVWTSPVFKPTADDVQFEHMVHLQEVLETRGKNRFFVPDFEAAEAFLRQVDLKEGPMFVLLMSSEVNGSYWCSDCARAKQPFDDALARAPPNTRVLEVSVGAPRDWNDDYNPFRTKSTFHIRKIPALLKYEGNLKTSHLVSEQFVTKPKLLDFVFGTKIPTPRPPKIIRSADEMLAFVKAYKGDYPLFLSFTSGANPHTGRLWCPFCDIADLPIQHYFETAAPENAQLVRVVVADSYGAWKDSNNPFRRQFVVRVAAIPTLVRVSKAQPTDEPSVREYLPLFEDTKALQTFFQAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XU72</accession>
    <name>A0A6G0XU72_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_001327</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000010">
        <property type="protein sequence ID" value="KAF0744189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XU72"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016874"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052116">
        <property type="entry name" value="Centro_Cilium_Assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23170:SF3">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23170">
        <property type="entry name" value="NY-REN-58 ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="230"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="311"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0744189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="661" mass="75685" checksum="449AA7F798C2A179" modified="2020-08-12" version="1">MPNGHAQLGHGFHRSREDKIRDKADTDGPILDLSNAYLGDDGCADIVRILRQYPRKTVLDLRGNRIQADGACILAAMLKTNVTLVHVNLEWNCIGVLDHGMEALASALALNTALTCLDLRNNSIGPDGAILLAQTLRRNRTLEELDLRWNDIGSSGGSALLDMLEDNSTLRRLHLLGNNVSIAITDAIYTAIKRNEQSKHHHAGKEYENNDEDISSLAPVVEQDDSPHILLEYMADKERLAAEITALKKQMELMESQVESRDSSISQLERELQLACDERDRWQQRDAQGRQQIVDTTARLEQCEAKRKQDLDEQDKHNKAMNETLLQLKQDKFELERTLARVQDDLEQAQKQSAQEIRLLEVESVKMRAQWQTSQDEVARLREQVADERKEANRRETHWQSEIEAVKQATARRAEMAIELLEQQLRHATSQVQDLQTELQAQRERAESLQSQLLELKVAHEAQLGDVTAKMEKECQERMERTVASVEAQLEAMRRQRVQLENDLDKHRLQLDQMRDDKARRTKLHEEEMEQRTATIQQLKAELAAAEEKLANVEMELVRQTRKTENVADRVNELENELDSATSMHEQRVAELEEAIGREKKAQEESAAAAREKQRRLNERIASLEATREAAKSEHDLELQAFATSVHEHVQTWMSQRPSKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XUM0</accession>
    <name>A0A6G0XUM0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1</fullName>
            <ecNumber evidence="1">2.1.1.57</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Cap1 2'O-ribose methyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_001337</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent methyltransferase that mediates RNA cap1 2'-O-ribose methylation to the 5'-cap structure of RNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA to produce m(7)GpppNmp (cap1).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside) in mRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67020"/>
            <dbReference type="Rhea" id="RHEA-COMP:17167"/>
            <dbReference type="Rhea" id="RHEA-COMP:17168"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:167609"/>
            <dbReference type="EC" id="2.1.1.57"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.57" evidence="1"/>
    <dbReference type="EMBL" id="VJMJ01000011">
        <property type="protein sequence ID" value="KAF0744074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XUM0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002769"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004483">
        <property type="term" value="F:methyltransferase cap1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016556">
        <property type="term" value="P:mRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050851">
        <property type="entry name" value="mRNA_Cap_2O-Ribose_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025816">
        <property type="entry name" value="RrmJ-type_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16121:SF0">
        <property type="entry name" value="CAP-SPECIFIC MRNA (NUCLEOSIDE-2'-O-)-METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16121">
        <property type="entry name" value="CAP-SPECIFIC MRNA (NUCLEOSIDE-2'-O-)-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51613">
        <property type="entry name" value="SAM_MT_RRMJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="1" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RrmJ-type SAM-dependent 2'-O-MTase" evidence="2">
        <location>
            <begin position="114"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU368012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0744074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="411" mass="46375" checksum="7D56513BD51F9D8F" modified="2020-08-12" version="1">MDDESLKDLLGFSSFGKRKHATKQTKKKNKVTKIDYTLPTIEFYRPATRMELNDLEGFLDMDPPSVVQGLPRLQKSLETVLDMKNKLHALQLRDDVYRDCRSLANPFELVGKWRFVNRSAMKLAEIDACVQLMPSPEQTQSVSFVDLCGAPGGFSEYLVFRADRNHQSIRGHGISIKVPTSTHLDWHVSKQVLEKLQISYGADNTGDLYKQTNMDHFACQVLQAHSEGVDLVVADGGFQDARNQSNQEILMHRLGLCEILVMARVLRKGGHFVCKSFELSSAFSLGLLYVLHHLFSEIAIVKPMLVKTSRPASSERYIVCRGWRHFQPSGVIAHFTALNKTFDAASPSTNVINGNMVDRGFLQFVEKSGHRSESSRGYRSNNIICYMLHKYPSTSRVTHSAGGMEIDSMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XUM2</accession>
    <name>A0A6G0XUM2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_001299</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000010">
        <property type="protein sequence ID" value="KAF0744158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XUM2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021435"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF246">
        <property type="entry name" value="TRANSMEMBRANE PROLYL 4-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="133"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0744158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="253" mass="28459" checksum="7050F9917EBBD041" modified="2020-08-12" version="1">MWRNSTAQASHFNVVSKMAEPTLAEKPILPSNAHRYGCAREECMFEVLDSVLTEAECRALINRMSPALKSVSRALSKLHPQGDQRASKTEYCLSVMENQQFANIIWQRILNSEAFASIYKYSEREGCGMPLGLAPRLRLLRYEGDDRFEPHYDRIVPDEATGSESLITVLIYLNNGGGVDFNGGETLYLDPDNPTRDAGVAVVPKTGRVVLFEHCLYHAGAPLDHSDVTIANKKYVMRTDILFRIQAKNKDKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XUQ7</accession>
    <name>A0A6G0XUQ7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="8">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_000884</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="8">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="8"/>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XUQ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012052"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07834">
        <property type="entry name" value="STKc_MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000789">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000046">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="42"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0744403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="393" mass="44833" checksum="D9AD343332078891" modified="2020-08-12" version="1">MASTSAPAEEVAAVGGGGKEIIRPGTHSFVVSGTTFQVDTKYKFIKPIGHGAYGVVISSQNTETGDKVAIKKVSKAFEDLVDAKRILREIKLLQHFDHENIITIVDLLPPPSISHFEDVYIISDLMETDLHRIIYSRQPLSDDHIQYFLYQILRALKYIHSANVLHRDLKPSNLLLNSNCDLKVCDFGLARGVEPDEDNMELTEYVVTRWYRAPEIMLSTKEYTKAIDIWSTGCIFAELLGRKPMFPGDDYIHQLQIICDKLGTPTEEELHFVTSEKARRFMKSQPNKPKIPLDKLFPNVKSNALDLLDKMLVFDPTKRISVEEALEHPYLESLHNSEDEPKSTTPFSFEFEKENLTKGRLQELIFEEVCHFHPECRQPSKKEVIGLSKDTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XUS8</accession>
    <name>A0A6G0XUS8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Ae201684_000891</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XUS8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012059"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09901">
        <property type="entry name" value="H3TH_FEN1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09857">
        <property type="entry name" value="PIN_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000011">
        <property type="entry name" value="exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000002">
        <property type="entry name" value="Exonuclease 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044752">
        <property type="entry name" value="PIN-like_EXO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF65">
        <property type="entry name" value="DNA DAMAGE-INDUCIBLE PROTEIN DIN7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="15">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="96"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="14">
        <location>
            <begin position="138"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="333"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="388"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="483"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="395"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="420"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="438"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="488"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF0744410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="544" mass="60932" checksum="1244FB97C5DC1FF7" modified="2020-08-12" version="1">MGISNLLPQLKSITEETTLHKFKGKTIAVDGYVWLHRGVYSCSQELCLGQDSDRYVNYFMERVDFLLNCGIHPYIVFDGGPLPMKKATEDERRASREKHRTAGLEFLKNKNYDMARQSFVKAVDVSPYMAYRVIQRLKMKQVKYVVAPYEADAQMAYMVRSGLVDAVISEDSDCLPFGCKNVLFKMDHYGGVEAIDMANLAKNKQLSFVGFSEDMFLDMCILSGCDYVASIPGMGIKKSHALVLRYGNSQKVIRALRLEGKLKIAKSYETQVAQARLTFRHQRVYDPITKTLVHVTPLAPSMLDQEMDFLGPLIPNELAKDIAEGIVDPMSHAPFSSHAPKSPVMPPSNATSTVKASATPMKTPEPTSTFQTPEVEKENAFTRLLQAGSLMPRSSSKRKPPTVHHKGTTKRPALQPVPASLSNPPVNTQRSRFFGKATVSSTQSKTDESYQPSKAFENLQQFKSKANDDLRLSKENNCLKLETDNDTLKQGASNQVMPQSRKEEKLQPSKINENLPQLEPIKSPVASKPTTDTFPLFQRFRFNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XVA6</accession>
    <name>A0A6G0XVA6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ELMO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_000872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XVA6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012040"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001158">
        <property type="entry name" value="DIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006816">
        <property type="entry name" value="ELMO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050868">
        <property type="entry name" value="ELMO_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771:SF56">
        <property type="entry name" value="CED-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771">
        <property type="entry name" value="ENGULFMENT AND CELL MOTILITY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00778">
        <property type="entry name" value="DIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04727">
        <property type="entry name" value="ELMO_CED12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51335">
        <property type="entry name" value="ELMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELMO" evidence="1">
        <location>
            <begin position="198"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0744388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="371" mass="41948" checksum="F22A00487FCBF6E2" modified="2020-08-12" version="1">MVVLCRFVFCGAEEDETFSVLLPSEPPPTLQLVRSYFPFEGLYHFRLQESTTNGSYVWRDLIHDSTVIPTTTSGDILLKVLQLSSTPQEKQKIYSSQVDNANEFEQFQAWFRAASADVPVDHERIPKSSSKQNLNTLWKSTKHQINKTTAKVWETVEFTAGRYFGSQTGADKPSAAALQQLAGASALSRTPFNESNREHLDYLRRMWVGIFGEARPFACPSSSWVEIGFPVDDPVGTLKSASCGMLGLHALVFFGEVHRNASQEMVSQHQYNYATVGFSVMAILADILDLDSGRFLERDEVYWKLFEDPIGIFELFSVSFHAYDSFFQHAKATRAFHTPLEMTGQFVYRVLMQGPKSIEELVNIAHELRVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XVR8</accession>
    <name>A0A6G0XVR8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="3">PPIase</shortName>
            <ecNumber evidence="3">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_001082</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XVR8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002514"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044665">
        <property type="entry name" value="E_coli_cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43246">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE CYP38, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="4">
        <location>
            <begin position="25"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0744616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="189" mass="21053" checksum="46C2B92D57FA0373" modified="2020-08-12" version="1">MKTSAMLVAATAAAVNAGTFNVLYETEAGNVTFEIHEEWAPLGAARFKQLIQDKFYDNAAFFRYVPNFVVQWGISADPKNNNYTEIKDDKWGVVSNLQGTLVYATGGNDTRTTQLFVNFKNNSRLDALGFTPFGIVTSGYDVLVNKTYSGYGESPDQDKIYEEGDAYLKREFPLITHIKKASFITHDGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XVZ9</accession>
    <name>A0A6G0XVZ9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_000710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000005">
        <property type="protein sequence ID" value="KAF0744877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XVZ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013679"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0744877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="265" mass="30037" checksum="27B9126141B649EA" modified="2020-08-12" version="1">MKTPSKKELIEKVKQYERMYQSPRQQDISFAATPEVVEQAPASVNYTHTMVVALLELRYNTYRTPFLQNRSSQLLGVLWENLCVKFNIACSLPYKVGVLSLKNKLQSLKKEYLAILSASKKTGNNTSDAINFPSYWDELVVAFGDKRGLADTEFGSEDPTDVNEDFEPNESNDDTELKRKLNDQADVDRKRNNRKRSKLDKSSVAEGLATLGSTLAQGLVNAASIQRDQGTSETEMLEFMREVKASMDQNRVIQEQLLKLLQDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XW26</accession>
    <name>A0A6G0XW26_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">deoxyhypusine synthase</fullName>
            <ecNumber evidence="5">2.5.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_001154</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[eIF5A protein]-L-lysine + spermidine = [eIF5A protein]-deoxyhypusine + propane-1,3-diamine</text>
            <dbReference type="Rhea" id="RHEA:33299"/>
            <dbReference type="Rhea" id="RHEA-COMP:10143"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57484"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="EC" id="2.5.1.46"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the deoxyhypusine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.46" evidence="5"/>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XW26"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007135"/>
    <dbReference type="OrthoDB" id="294378at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034038">
        <property type="term" value="F:deoxyhypusine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.910.10:FF:000001">
        <property type="entry name" value="Probable deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.910.10">
        <property type="entry name" value="Deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002773">
        <property type="entry name" value="Deoxyhypusine_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036982">
        <property type="entry name" value="Deoxyhypusine_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00321">
        <property type="entry name" value="dhys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703:SF0">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01916">
        <property type="entry name" value="DS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0744697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="368" mass="41108" checksum="F0CE8B208F410575" modified="2020-08-12" version="1">MSSEGGEAPATAQAAVLVKSERLDNGDYSQVKGYDFNKGVNYEELFKSYRYMGFQSTNFGKAVEEINRMRAWRLSDEPIDENDDDELQDPAVRAATKCKIFLGYTSNLISSGLRETLRFLAQHKMVDVIVATAGGVEEDFIKCLAPTYVGDFALKGSDLRRRGINRIGNLLVPNDNYCKFEDWLNPILDSMLEEQKTKGTIWSPSTMIHRLGKEINNEESVYYWCYKNNIPVFCPALTDGSIGDMIYFHSYRKEGLILDIVSDIRRMNDHAIRAKKTGAIILGGGVVKHHILNANLMRNGADFAVFVNTGQEFDGSDAGARPDEAVSWGKLRLNATPAKVYADATLVFPLLVAETFAKDFVPSTNENH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XWG3</accession>
    <name>A0A6G0XWG3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_001241</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XWG3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021810"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04371">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF289">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE VIK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="323"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="DEP" evidence="7">
        <location>
            <begin position="615"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0744788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="767" mass="85856" checksum="14D220F956AEE83F" modified="2020-08-12" version="1">MENATDVPNATAASLLGNMTTKAPKTLSPAAIEGLRLQQFVNNQYQILQIVYSISYATMFLLSVFLVVYLRRNRWTAYQGDSDATRKAILPTFESLLWVLCGTTGLYTVYFIVAAIFSYTDPITWRWFAELLPAGRQFILFLILSFLLQRSVSVQSLRRAMLISFILAAIPVVGVHILDQTKQTTLIQSIVPNIYRLLLCLGFVWLYFRPIGRANARTQRELAAFAMVYYVIVFVYSGFFLAKDSSTGFMLVFCAVIWASFAPVVVWRLLKADTEHWRGLGDRACELQQLFREKQGIEEIVSAQGLHVLLEMHHRDLIDFAHLELERKIGVGASADVYRGKLRSTTQVAVKVYSPSEISEGTILAFSQEAALCRALKHPNIVYFHGMCICPPMICLVSELCRGSLEDALMQPRQGLTEPMWPKLCFMLDAARAVAYLHSFSPPFLHRDIKPANFLLGANNRVKLTDFGESRSMASGKSADSQMTMRGTVDYMAPEVIEGKAGKANYTQTADIYSLAITLWDVLHPNQEKFPAGGNHLNVYKMVVEGQRPPIDPEIHPTLHELLENAWHADATFRPAAKVIVATLEDLHEELCSEIMPRLAQAMMCLSLPIKSKPTFSGHDLVTCLIDHEYAIEVEEAVRLGNALMDVGCLHHVKHALPFEDSTVATYCFDEHQLDLNDPLDEDEAHVTIAGDDSSYGALSILGDASGTCACRRLGQGHVKMKPPKKKIFRRQLLSDQKVLTVNLLRDVVDEFEDEGSYAMTNQTTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XXL0</accession>
    <name>A0A6G0XXL0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Replication factor A protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_000270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XXL0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019652"/>
    <dbReference type="OrthoDB" id="188186at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04479">
        <property type="entry name" value="RPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013970">
        <property type="entry name" value="Rfa2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15114:SF1">
        <property type="entry name" value="REPLICATION PROTEIN A 14 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15114">
        <property type="entry name" value="REPLICATION PROTEIN A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08661">
        <property type="entry name" value="Rep_fac-A_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0745238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="107" mass="11454" checksum="0F4AEC075FB62409" modified="2020-08-12" version="1">MSDAATAPRVNKAIMAQFVGRTVALVGSLESWTGSMAVVKTSDGGLVTVHPQPGADYSSKFVEVIGLVQPDGSLKEYKCTSFGDDFDLKNYDKLVHLIHGKFSSLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XY36</accession>
    <name>A0A6G0XY36_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_000113</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000001">
        <property type="protein sequence ID" value="KAF0745661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XY36"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013763"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13999">
        <property type="entry name" value="STKc_MAP3K-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF214">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="409"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0745661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="692" mass="75165" checksum="267250DB93A5FFF7" modified="2020-08-12" version="1">MTTVSGDAIKTSFTVDTLTAYCHYNAPQNYPGCFARANEPWANWIDLGSGKKMSTVEDTDVNSSNPNYAKPPANYTFELLDSLTYNATIIDMSGHGIKRLGNNMYNFSMSLGAPRALSVTFLNLSSNQITMLTRATNFADSLRNLSFANNKIATFSGINSPRLQNLNLRNNQITSIKSNDTSFFPNTLQTLDLSGNPLTEIAQVTLPTSLIELDLDQISSLTIRQVDLTSLSILSLQDTTVQNWFVSQDQYAKLVNLVNSKLLTIRVTDKTSIKTSSCDNVQTLPTSPSPLSICVDAPGGSSNTTVYAVVGAVVAVVLIVVGFLFYRKYSQRRAAQKRAATPGVSFSVFVNQTRRNTNLYNGMSDAKGGVVGSGGRPRDPTQLATSSVDKYDVRFDPAMQQFRVEFKSVAMQNVIASGGFGIVYKAVYKGETVAVKQLLPSIDGNSEAVTDFMEEIRLSSMLDHPHIVRFVGVMWTTLKDVGALIEYMPNGDLATLVRATDANVKLVWPNEEMSLGNGIYSKIQVLIDVASGLEYLHNFHVIHRDLKAKNVLLDANYSAKLSDFGTSRSTIGDATMTAEVGTIAWIAPEVLKGKNYAESADMYSFGVLLSEVDTGISPYSHLVTNGGSQLPKPVIAMKVMDGDLRPTFTPSCPPEILAIANQCLLHDPSARPTAGQVGRMLAALLPSQTHAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W2P6</accession>
    <name>A0A6G0W2P6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_019221</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000509">
        <property type="protein sequence ID" value="KAF0721138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W2P6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005623"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014575"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF288">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="296"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0721138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="757" mass="86569" checksum="7444D17D1759FB22" modified="2020-08-12" version="1" fragment="single">MYYGQAVAVKRFDQIVSADSAELEKVIKKEIKAWKDVSHEPNILTLVGVCTKTQPPILVSELCETNIRRYVRDWPEALLPMIYQFACGLAFLHSKNIIHRDLKGDNVLITFQKTVAIADFGLSRSTESLKNTRTGSKASGTLNWMSPEQFFRPRSLTTKSDIWSFGMTIWEILCNDTPYRECSEYEFQDILKSEDDRPEKPKDLNPCFEPLWSLVTKCWQLEPNARPSAKDIVEFLVRTYNAQDMLHQQESFDECINVSDTSEMEDIDDTVTSLNQLIELIVTEPSREWPLLNNYVLRPRILGTANQGIFRAYNERQPWKHLAVKLSDNSHEMDFYKSVVDIEKAKDYFVECFESGAWYVRGYKCFAVILQRGGRNCENYCQYLLKDSIAKYRFIEQILAATQFLHSQGWIHGDIKLENVAYFEAEARFKLMNMDHAQNIDAAITKHCVSEYCPPEMAMYIRGHKKILVASEKFDTWCVAVLVLKLFLKDGVLKEFSGLDEKAIIQLIASPDFNLDHSLNASDLKPPQKQIFALCLHPDPEKRGTLDDILAILPERTSLWIKLSRSIPFAWRLDGVIEPLPRGKALREMSLRLTSLCEMRESSSRCEHFYQDASIQVQADSTFVRDALPFLKTSSLVIKAIGLISCYDIQFGSDYNVDVSDGIDVEKTVLALQNFHGVVSSTAPPRLVEIVNHLENGDLEEEEVKTVAKEIKRIIEDNWKNNTEVMATALRNLGLRLDGDVIGGLTKRTIKSQSPFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W3G5</accession>
    <name>A0A6G0W3G5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_019079</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000386">
        <property type="protein sequence ID" value="KAF0721561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W3G5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003657"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052050">
        <property type="entry name" value="SecEffector_AnkRepeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586:SF3">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0721561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="189" mass="20929" checksum="E76D4A3186C4D19F" modified="2020-08-12" version="1">MDWAAATGNLKLVQWLHAHRSEGCTQSGLDEAANNGHLDVIEWLVTNRDEISLSASAFANAAQSGHLHILQWFVSRGFPLEIAGYNPFDLAAGNNHMAVVEWLHRQNCLASSYAMEFSAESGHLAMIQWLHTHRDEGTTEETFHMAAHCGHLDVVQWLSLNRNDVCTTEAVDSAAGNGQLDVLKWLLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W3X6</accession>
    <name>A0A6G0W3X6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_018990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000370">
        <property type="protein sequence ID" value="KAF0721710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W3X6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020499"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0721710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="114" mass="13427" checksum="622EFC677D743398" modified="2020-08-12" version="1">MEDEVPIIKTRRHYSLETKRNVLRALSDHTQQRVADLSGIPLRTVQNFVREKEKIWASLHAKRRFHIGEPGRPEILPGGDDLLDYMVAMREKHFPLTTYHVVQQVKANNQEWIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W402</accession>
    <name>A0A6G0W402_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WRKY19-like zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_018915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000365">
        <property type="protein sequence ID" value="KAF0721772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W402"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019145"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056866">
        <property type="entry name" value="Znf_WRKY19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827:SF1">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24906">
        <property type="entry name" value="Zf_WRKY19"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WRKY19-like zinc finger" evidence="1">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="WRKY19-like zinc finger" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0721772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="190" mass="20531" checksum="27034834A1041B3E" modified="2020-08-12" version="1">MDLLATVFHNEFLQGASSATEAAPATATPTIESIVASSKRRCNVAGCANVLVSKGRCIRHGGGGRCRIDGCDTSSKRGGLCWKHGGSQACQHEGCPNLTKSRGLCWSHGGGKPCASEGCDRPCLRGGYCWSHGGGKRCKVTECLRPAYKRNQNYCDQHWAEQSSNNHTSASYLRCLVVFIFSFTILSKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W479</accession>
    <name>A0A6G0W479_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_018884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000363">
        <property type="protein sequence ID" value="KAF0721818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W479"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020468"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0721818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="466" mass="51172" checksum="0DD3552BE62B1262" modified="2020-08-12" version="1">MSDSDSQQSSQSPDNVPGNRSREQQRGRPLRRQVPSPFRSPPRRNPPPVDQRVVFGGYVYQPPATAAPTPAAAPNVSPSNSTPGTAQNTPLPADTADDVDMGDDDGSTFVYNAPALPQPPTFNGSTKAERRTFIRQYNKYLDQINALQCKGTRPFVMPVSACMDVSTKKRLVMWTFGNRDYRTIDESEWEAWFGKAFDEEPQDLEVLKKGLTSAIRFNTIILGADSRIEKMLEDLMKALERDDQTWVLEQEGKIVVDIMVKAMKPTTLQKSVICQLAMNRNKPLKSDVFRFVEWLRVHTAGYQLYAPVDEEKPPSPPKNAKIEKNNGSGGGANRGTPANEQRGAMPVRPKPKCLKCGKDDLKVSACPKCAHGEADKLLKEQLEKWEEARKKVAKLNQPVHQSLGRGAKIEDIVSVSTTLLDTGSDVTLVTAGVITSLEGAGVDVTNVSAEAIAIQPYGQAAALKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W4E0</accession>
    <name>A0A6G0W4E0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_018837</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000361">
        <property type="protein sequence ID" value="KAF0721850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W4E0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021526"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0721850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="145" mass="16888" checksum="33525BB1EBDFD5CF" modified="2020-08-12" version="1">MSSTNEMQCKYAYKECSNVRTYKRDGQLHRLCEEHRKKANALQKVYATRRRREMRTLKRQILEDKLLNVQVDPVPFANIELGMDDNDVVDVADFDGLFDEDWDPMQRTSEIEGLTDAEYAFLREAIKKAKPCTLECTSFVAVCLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W4E9</accession>
    <name>A0A6G0W4E9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_019056</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000382">
        <property type="protein sequence ID" value="KAF0721589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W4E9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004085"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0721589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="268" mass="30519" checksum="5FEF19BB0EDFAA25" modified="2020-08-12" version="1">MAKKTIVGKRKFEFRTPQKHASPFVFKRKRHQVENDDNDKNERIKHMQVHDNELRQKYFKSHEATNNPHAEIFDALCAIVERTIDHTASSTTSSGETNKQLLHVLDAAAVIIKTEFASAATSNTDDESGSNSPHHDSVHTLIRSLEEKLEGLDRCENEWKSFHDMLPSVLSDQPLESSVVVQDDRPFPCVEIPAKLAHDQKELTKRVQTVGTKMHFLESSLYEVERMVHVSDALRSALFDAFHASEFQGYQHMQSPKDAIKALMALFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W4V6</accession>
    <name>A0A6G0W4V6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_018681</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 5"/>
    <dbReference type="EMBL" id="VJMJ01000347">
        <property type="protein sequence ID" value="KAF0722118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W4V6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002147"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811:SF19">
        <property type="entry name" value="39 KDA FK506-BINDING NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811">
        <property type="entry name" value="FKBP-TYPE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="7">
        <location>
            <begin position="264"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="88"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="356"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="117"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="132"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="370"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0722118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="399" mass="44234" checksum="CD4FA50377DB2B7D" modified="2020-08-12" version="1">MVVVKGKDKRRGNESDNLEVISHTKGMRTMGGPTSGRFAADMRVRVGGYGRPDQTWGVDHPWHKTQDVDLHQMISARDRLEEGLLVEEKTQGQGLSRAALKRKKKQQKKGIVPAAQTAATPENETKPPTQHSTEEKPAKEKKKLALFDDSDDDNDESEKPAPEEPAKKAKAEQPKKQQKTEQPKKQQKAKSKRELQKQQRDKEEAEKDLHLLVEEKPQLVVLPLPEREALAAEYDASLGTEIETPSGLLIRDVHLGQGQLPAPGQTLTVRYKGSLGKGGSVFGKGMLTVKFGQGAIIAGWEEGLSTMRPSGKRLLTIPPALAYGSEGKGEKIPPNSTLYFEVELVRIGTRQRDAIGEDDMPLPKAFVRQRIKESKGKKKANEDETSNAAPAKKKKRIRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W5C2</accession>
    <name>A0A6G0W5C2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_018604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000343">
        <property type="protein sequence ID" value="KAF0722222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W5C2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013641"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF317">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="382"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="506"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0722222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="589" mass="64479" checksum="519EF0EBC4008021" modified="2020-08-12" version="1">MQSRPRDTRGEEPSPWLHSEVHPTMLRPELGWAPLNSQKRRSCYCFHRLLSYWRINIPPKTAAELEAESSLFVVGFPSGRYAATRRVSFHRLALALMAILTQACIGSVFAFNTLAPWLDNYFKETASFRIFLTSILSFGVVAAVSGPWLERCGPRLGLGVGCAMFGLGLILSQVAVAVQSIDLLYVGYGGLVGAGQGILLLSSISTVQKWFPDWRGIVTAICIGANSMGSVAWAWWYELLFRHSTALNYVFLLTGGISIVILAISALVFRTPPPTFSVNGLDIHCLPVSSASRNAQAVDQYLGQGMTLVNYAALEPTQVETDKDYFEQVKGLTLAQCIFSTDFFWLYVACAANMMPGILFLPQAIQAFTNIANQSTQQAATFVWNISLSNCSGVIVAPLASDLLIRLFYVNPAFGRKLVFTVMLLTQAVMLPLVSANLTQPVPWYALTFACGGGFGLMPCLVSDLFGVYNSGTMYGLTLSSRAIGAAIVGFLLPSLQPTKSALDNQFQAMLILAIVGVVAMLFVRTNSVDRFYHGYRLTVCGMTVFQVPFRRKAPATEASNTQRMESTNAFFLVNSSSMMQRSPIEESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W5J4</accession>
    <name>A0A6G0W5J4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_018449</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000336">
        <property type="protein sequence ID" value="KAF0722380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W5J4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015357"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="313"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="324"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="340"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0722380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="381" mass="42421" checksum="700CA1D1C8C683B4" modified="2020-08-12" version="1">MPFQFADHWTEGHQTTLAALRTALGEDDLAAQLGPMEEQQRLHLVEVIARYGDAVLAASLPSLQAQVVALQTEVATLIESNNQGQHALQESQANALQLQQQLGQAVAAHPQDAAPATSGEPKKVRIDFPPFKKSDNENLLRWISHVLWLRLSPAFSADPLNQLSLKSNWFPDLDTFFAALMAFLAPPDSDFRNRTLFHKSVQGKLSIRDYANRLRYIYTLMIDRDSLNEATRVSVFMDGLVESPSRSELFRRIPKTFEEAVEIALKEEFSQASAQGKSAGSDQWDMDVSSMEQFPQREAYRVPASAPPSQRPCFECNQLGHFARDCPRRGGTPRQQQAKARYPAPAPQGQAQSPRRFGRSPGVKGGPNRRVNFRQGNGGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W6R0</accession>
    <name>A0A6G0W6R0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CW-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_018000</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000319">
        <property type="protein sequence ID" value="KAF0722923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W6R0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013983"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.100">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011124">
        <property type="entry name" value="Znf_CW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46245">
        <property type="entry name" value="B3 DOMAIN-CONTAINING PROTEIN OS07G0563300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46245:SF2">
        <property type="entry name" value="B3 DOMAIN-CONTAINING TRANSCRIPTION REPRESSOR VAL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07496">
        <property type="entry name" value="zf-CW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51050">
        <property type="entry name" value="ZF_CW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CW-type" evidence="5">
        <location>
            <begin position="137"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="CW-type" evidence="5">
        <location>
            <begin position="265"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="CW-type" evidence="5">
        <location>
            <begin position="390"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="191"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="434"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="507"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="210"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="224"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="249"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="448"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="518"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="528"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0722923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="676" mass="75671" checksum="261EFC280DEACEC7" modified="2020-08-12" version="1">MADSDGDTKHESKKKDKKKKKKKDKKKDKKQKKEKKSGGKSKDDSSDDETSEPPLPAETKVEPSEESVASSIPLAATAHSPDSPPHKLDLNIVIPNKDRDSDDSKTAESVRNKKKSKKKKRARASETTSTSGNDVEEADEAKWVQCDRCKKWRTVPEDVDLDKISQTAWYCTMNSWDSKYASCDVAEEVVEPKAKKTKVEPPPDDPAPPQVSASSPRSSSATVDIRKREAEKKDKLKLGKKPKDKLKTQVKSAAKQTGASPRDDEPTEEKWVQCENKSCGKWRVVPPHIDIASLPLKWYCSLNTWAPSLATCSAENPVEVESLWNKKAVKPTLPKSSAKTTGGKSSPRAQLTLPAIPTVLDVVSTSGDVDSPMSKGKKVADVAKKVKSPEKTVLEWAMCDKCKKWRKLPAHVKSATLPEHWFCSMNHWNPAVASCSAPEESDQDPTPARVPMPLPRPAPRRGKLSYIELLYAGNGHMRKAYTEESSTLSFEFEGKLYHRDDQYRKSSMYATPTPSTPVDDDVQDENEPVPTEEPTAPTLSKAELDKIRYLLQSLIKENEGKSILDMVALLHSEKTGVNINEYYSYAAVYQTVQAMVRDGDMEAYRDERMVTVTVPTQISTYAQAYYVAGENNTENRTWVERRTSPHLLYQRKIQYKLPLKVAKPWKQKGFTGWTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W7A4</accession>
    <name>A0A6G0W7A4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycine zipper domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_017991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000318">
        <property type="protein sequence ID" value="KAF0723027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W7A4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004534"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0723027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="25194" checksum="70AE032CB33E97E0" modified="2020-08-12" version="1">MLIVEDENLNPTAPDAIVESRSWNARSTHRRLLVRRDDKKSWVSVAVGLLIVEITPQGAMRFWTLLAAACTAVVAFDQRRNDVQVMHSIASTTDVVHLKNRVLTAPGKANQVNNPWDKWERWGFKNGGRAGAFLGATGGAIGGTLAGGFAGASAGPVGSAVGAAAGVTGGLYTGSILGRNGGAMAGAAGGRVVDKHLAKKKAKISSQCSTTGRSDEVIWPKQRDGPVSLQAPRLLYPTNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W7E8</accession>
    <name>A0A6G0W7E8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_017796</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000313">
        <property type="protein sequence ID" value="KAF0723175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W7E8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015280"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0723175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="189" mass="22296" checksum="1BFC1C4161966DB9" modified="2020-08-12" version="1">MFTIFANFENVAKTWWFDLLESTPLVRSTIVESFDRRVLYVRQEYPQLKYNRMCVAGVFLDEEKDRITITQTGIALGDRFPFQEGESRTTGFHWVVFHHVTDHVTLVRWSVLNLCPVNAQGSLSLREVAQNLRCTLTPNDSDEAIYLKIQNAAQRALDNFRDLFRQRCDRFKLEPFHIRSRNFSFEEHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W8F3</accession>
    <name>A0A6G0W8F3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VPS9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_017540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000301">
        <property type="protein sequence ID" value="KAF0723573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W8F3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013258"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="2">
        <location>
            <begin position="341"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="494"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0723573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="504" mass="54787" checksum="0465593D07DE57FA" modified="2020-08-12" version="1">MSTLQTSMWLCHPIHLHSFYCAVEIESKSILKPSPQCVVCAKVADGAQLPVATCVSCGAIVHRTCLSAIHEQNTAKEYREHRLVMPVCTTTRRYSSPPPPTPLSPRLSSVELHLLEELSLDPTLPPQSPLHDKNKSLALVYVQRYAPYVAGGILLGGAALFGMPAVALTGLGVGLSGHTYEGISKIVSGRPRSSSSDIAAQDAEWARRICWDLKQSSDIADATYKQDAALLRRIHNNLEASPTAEEVYRMLFNLFASPDELIGRVNTALCAAFRRRAKATTTSLQSLVRDAQVYVGHVLAVTLNTYPALSTTEEGVVMTTEAVEKIVYSDIYPVVFAAFCREYSRHDATLQAHIRNVQAARRRRLSTDPDASLDALASVHYPLGKLQVITEAFRAICTAAEVRLATAPSADTLLPLVVDWIVAGGGHVRHLVAHLAFVSTLTQGGGRGMEGYALTTFHAALRALGATDTAEDETTEEDEEDEEFFDAVEDSPRLKSSSLPLRPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W8J6</accession>
    <name>A0A6G0W8J6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_017622</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000305">
        <property type="protein sequence ID" value="KAF0723467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W8J6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013103"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0723467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="110" mass="11967" checksum="D663B519C66A2BDC" modified="2020-08-12" version="1">MDNVSLSYRDVNINSTNVLEVTVGVVVGSAVAMNATDLRFQDMMFGNVTNNTPTKALVANNVLFDETQLSFDEIKSNVYVVNNDPFVSNEVPPLVPSLVGMVILVMAAWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W988</accession>
    <name>A0A6G0W988_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_018146</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000323">
        <property type="protein sequence ID" value="KAF0722794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W988"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013032"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="369"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="6">
        <location>
            <begin position="28"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0722794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="479" mass="53079" checksum="EF4D8BE39928AD51" modified="2020-08-12" version="1">MHIWALGILCVIGGHYYGWNTAYATGFIPFFCSQAMMGTMFIAYVACISEVGGKVPGGSYGLARAVLGFYPGFMLGCLELLEYVSFGSVSILYVADFMTEYFEWPRHYEPIVWLILYAVFIAILESKGKYMWRFILVFAIVCLLPGVLYIVSSPPYLNLKQHGYLSSAFFAILPTTTVGYAGIESLTVVTGFAKDPAYSIPKGTVADVWALFVSSLWIILTIASLPPGLDVTSADEYFLNRGLSLGFGFSASLSKWLMIIPQLGMAMSFFIPYARLTQAMADSNLLPAFIRVKGQKTTLRAMIVSSIFGYLLCIVSFFSDEFQATLQNISIVAAAICYASQTYGFVLLRTSYKIETSGYKSPYGLLGAYYVWLVSFLLFLSIAGGFQDDEGIAILSTIGFIAVMSIYYRFGCQASQSVSQEEYASIFKFSVMKFNKLRQKKRRPSSGGGGTSLWTKLSFWTGSKRSSITAKDCFVRRYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WA75</accession>
    <name>A0A6G0WA75_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="6">3.2.1.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_017903</name>
        <name evidence="9" type="ORF">Ae201684_017904</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="6"/>
    <dbReference type="EMBL" id="VJMJ01000316">
        <property type="protein sequence ID" value="KAF0723100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VJMJ01000315">
        <property type="protein sequence ID" value="KAF0723112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WA75"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020167"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF34">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036384610" description="glucan 1,3-beta-glucosidase" evidence="7">
        <location>
            <begin position="17"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="8">
        <location>
            <begin position="405"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0723100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0723112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="489" mass="54773" checksum="6564003A4C9860EE" modified="2020-08-12" version="1">MGLAIALSALAAIASAAHIQHDIRAGNTRPNGVNIGGWLLAEHWMTTDSVIWQGVPNATADQGEYPTMAYLGTQEGTSRFRKHWASFITEKDIQQIALANLNMVRVPVGYWIQGCDHLTDAVLKDHCNRYAKGGLEYLDKLIRDWAWKHNLAVLISLHGAPGSQNGHDHSGSDDGKVYWSQYPSNVKATKDFAVFLAQRYKNDDAFLGIGLMNEPIEPVDTKVLLQYYRDTYKEIRAVSDCVLSLMPLLSHRKPGHGEYMDDFAPEMTNVWHEWHPYVNWGYEKMTEDQLINQGVAGRVSDINNWKGKPLFLGEWSFASPKNDSTTRRALRGWAFWTWKNSSDTGDNIDRWSLRSALNLANSLTPTATEKATAIYDSTGKSLTLRNDPWRLVNEKTWINAVGPAREWWYDSNAKTLHSNLNGQCLDGYPTQNGQYAVHGYACAAGNQNQVWTLSNGSVVHNLSKYCLTSSLTLVACDASKANQKFTITN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WB60</accession>
    <name>A0A6G0WB60_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_016798</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000269">
        <property type="protein sequence ID" value="KAF0724504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WB60"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001158"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051625">
        <property type="entry name" value="Signaling_Regulatory_Domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872">
        <property type="entry name" value="BTK-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="414"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="466"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="148"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="164"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0724504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="608" mass="67472" checksum="BE8EE32828E0A706" modified="2020-08-12" version="1">MARVQGATADETQLREIGDLFDVIARKDNGMVTKEELQLVLPYTAGAAKADVLALMDEMQSKQLVLNKKQFVRFVAKRAYNSWNAHIEKLENTSLAHVIVSMKRRKHLVQFSTFYSSKGVAGAELIVPVETDTHKPVLDKRRAIEIKHKKYHQEPEAPSHTTHSTKEHLHDHSSQKQRKDLIHQFRTLKAGQQHVYAIVFNMSTRALERHVIYTTKASVRIYCARYFCIVLTPSRDIQLVASSAYLGHLYHDRVHACHGPPPDLLMANNFFPSSCLKAEEPMWKNVLHLPQEAKINHLSCAYGNLTFSMAGRLYEWGVGEVFSAPPESKCFFPSLDDLQSLDTSSYHIVPRQFHKAVHEYSMHLSRHLKDSCCEVWNNAKICMGPHELFRGFIPSDMLAMVCSSQSYVSLSRGGDVYVWGRGKLGQLGRGSGVDYIGAPEKLRGFKNPVKVISCGATHVICTDSRGAVLAWGGNMHGQVGTGLTDDVTEPQVLAFLEDKVVIDAAAGDDHSLVLTNAGDVLSFGSNWYGQLGQANSALLYSPVPALITFSDEIADPIYMIRTVGATAAAVSVTGKNESFSFLNDSRVCLSLGTMCRGVVRSCESLWAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WBF3</accession>
    <name>A0A6G0WBF3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_017052</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000276">
        <property type="protein sequence ID" value="KAF0724239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WBF3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010679"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173">
        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173:SF74">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13606">
        <property type="entry name" value="Ank_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="4"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="37"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="70"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="104"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="137"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="170"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="203"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0724239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="238" mass="26141" checksum="6C9ACE0C13B0F466" modified="2020-08-12" version="1">MVRLTSTPLHVASQEGHLVVVKHLVLNGASVDTAYKDRQSPLHLASQSGHLDVVKHLLDKRAFVNAVDRMDRTPLHLASNAGHLEVVKHLVDNGANVDAIERSFGRTPLHLALQEGHLDVVKHLLDKGADINPANVVGRKLLLLASQKGQFNVVKHLLDKGADINTTDKEHRTPLHLASKEGHSDVVELLLDKGAGVNIADKFRWTSLHFAAYSRHKDIVMLLMDAGADMNIETIVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WC78</accession>
    <name>A0A6G0WC78_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_016540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000257">
        <property type="protein sequence ID" value="KAF0724889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WC78"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002784"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0724889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1051" mass="117544" checksum="BC4A453C1B380645" modified="2020-08-12" version="1">MTTPTFEALQVKLNSTAEYAQSDASSEVFDLWFELATQFAQGQMNVLEIQRHTLHALEIMLTTYSIQRIRDPSTDLYAVRELFRHAQAIFEILRTKPKFAPLLEPNSEQVLGPWLRSTGVRSLEAVAYAETLHGGVRVDAFSTMQALLELWEFLSDNGTNPWAHVYATTWNLHFELNHVAHTTASVSTDAIVRDAALQTIQQMARFDKTYAPVIALSRVARDILALSPLWSMGVLASSVAMDQLLVKMVATSTDHAATKSLFCTGVMESLYEALMNNRSSREWAFDAKAYEYNLCHLFRACYQTYKMHPNEGNRVVLPDSYLHAIESVLLHYPDCVSLVQFALDADEYCMFVLISRISHAFQEGVWTDQILPFARAQLALLPLQGVSGLQRDQELVNMIREACRLYYLNIDRVPSANLGRHVFLTVTQAIRHGYIETERFTEILALILHRHYSMGHVQVYQWIPTLFLPEVSHNHKTSRALGESLLIALGLQNSSFGLENAIMSAETSKAISEAFSVILAKFRSGPADMFWQEVCLNFGPFIQEHRTALSALLHSITMELETCQTRGSIAVDRLDSLTELLHGISMRIDSADASTVFRLSLQVISLGAGASTAAMFEDTLVNAIEHMSEKDSLDLITTELALSICGPRTRTALAKLVPHMCLEDIDPHVRQAALRCIVSHPDLIRTNSVVVIRSLYWIHNPMMKAQDTSDKMCVDQLALATDACPVLVVLASVAPIYVKECIVKLLSAANLNAVNDALNEANIIAPHLDTLVATVPRNALLSFVLTTSGMLLLPILTHLSSKWQQLAQEVIQSGFLIERDDYAVFTGQFPSLERLARNKHAYKRTEEGKNTLKQILGADDMTLVQSVPSRNQLHQLIVNELDHGAYMKAIRLANTMRAWYPDDYIQMGTHELVTKTLLPLVADHDFPRIYLGSYTSATLDAFPTYYRTMHEVKLLFPTESEEVLHLSKHLEAFCLAKLQEILMHSGPDQAKEWMDFYGFHVPIVSSMAPTKNVVATVPLSPSAPPWAETMLHVLDGELPAVALDSIAVDNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WCW4</accession>
    <name>A0A6G0WCW4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_016358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000250">
        <property type="protein sequence ID" value="KAF0725127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WCW4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014901"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0725127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="253" mass="29184" checksum="75E60BB2E69BA88C" modified="2020-08-12" version="1">MKQFFGGTWIGDSFAAEDKTLWLILWHQDGSMYETTRNASDKPRALTCSGDEYLAVIHDTFHLGHSLVTLSNPVVENDQLVVELREERDGMNLRYDSWTMRLASPKDQRTVREKWCGAFADEEQQRRDLVRRVADLETLLKQKESLLHDAIQAKVDTEKQLVLQCVELINTKKQHIERLQNSLPKANKRKQPERGEEEDEEEEDEGSAAEEEDDDEVVEAASQAYSHVPSQSTHISAKRLLKQEEDDDFLNML</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WDL0</accession>
    <name>A0A6G0WDL0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_016152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000243">
        <property type="protein sequence ID" value="KAF0725381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WDL0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009930"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0725381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="139" mass="15408" checksum="EA816B885CFC1EAD" modified="2020-08-12" version="1">MQEARRHLDALFVVHAGISIVIGAACLLLPHSLAMSALKTTEYSHLVHEMVRLYGALTLAQGWLVWKTRLVGDGLIRKTFCQAYCLCFSLQAIAMLRAQISSPESHSVLNWINILVLAGLGGAYGYFLFFKTIKAFELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WDV4</accession>
    <name>A0A6G0WDV4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_016319</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000249">
        <property type="protein sequence ID" value="KAF0725167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WDV4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007335"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018270"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="630"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="647"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="556"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0725167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="667" mass="74205" checksum="C43621C0863E8EAD" modified="2020-08-12" version="1">MDPRRQEDLNLGPDHPDAFIAGSERAPSQTNTMTESAIVTYTESPLTTLRKRDLEYRLLHHANSPEQRDPEKRSRQLPAEYSDEDMGSDTKSDLAPSPALHASKAGPSDHSGSELSFEPRSSLRELPSWESYDDSSFPAQDLIHYNGDPVSTINVPFDDAFTLEDGACVSDLTRENSQLTKQVLFLKEQLNRHQQELQELRTQTPETQQATEPTSVPTSSDSNEVPALVRDLNERIASLATGLTSNMNDLKESIIVMDQDKKLGQATKFTIVPSSDHQDDCAFFIRQLLETADRCQLSDNDRRSLLGLKLCSDKTPSSLRKWWISFAKTKQGETWSDVLAEFQDQFCLRTSRQKVTDLLNDSYEDETVRSYATRLQSIIDEVGFPADQGVNLFKLGVRHLKTESCLENTDRELKTIADCVKLLRAREVPLDDAPMPASRPKSRAGSASDTASTYTSQSEASSDRTPPRSPRHNRRGSRVSFDEPSTVERLLATLLDQEKEFVAHIERSDRHHQSLMDALMRPTGPHFVAPIQPSTAPQYGQSYGYPYTPFAPQSAVPPAPLMAPQPSGSSDPPQITPNASQNAGLPQTGRITPVIISDKPDMETTTGIKICGRCKQAGYGRDNCYRKNLRCSVCREVGHYAGEHARTCNICKKVGHVSSRCPEKTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WED4</accession>
    <name>A0A6G0WED4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA/rRNA methyltransferase SpoU type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_015859</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000234">
        <property type="protein sequence ID" value="KAF0725706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WED4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016899"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051259">
        <property type="entry name" value="rRNA_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43191:SF7">
        <property type="entry name" value="OBP33PEP LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43191">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="tRNA/rRNA methyltransferase SpoU type" evidence="3">
        <location>
            <begin position="6"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0725706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="218" mass="24243" checksum="2867B345C54A47A2" modified="2020-08-12" version="1">MEGHEFYLVVSNVTGRKNLGTFLRTGTAFGVKQVLVVGSDRFGTHGGHNAHKYVDVTTFHTCADALAYLKTRGCRVLGLQPSADGSTCVESSPFEGPTAFVLGNEGTGLSEDQRRICDGFIHVSHYTPQQTTPSTVFQLDLTVQLGILLHGFTKWSGRYQERRIEDTSTRGKFELAERKSRVKVDKPDVTMERQKVKESVDAVMNDDLDLQLWSIDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WES2</accession>
    <name>A0A6G0WES2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_015825</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000232">
        <property type="protein sequence ID" value="KAF0725863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004385"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000289">
        <property type="entry name" value="ABC transporter G family member 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000528">
        <property type="entry name" value="ABC transporter G family member 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="510"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="542"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="579"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="665"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1081"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1113"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1153"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1192"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1222"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1322"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="39"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="744"/>
            <end position="985"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0725863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1349" mass="150565" checksum="255BC9DE8A6EF6F6" modified="2020-08-12" version="1">MSAVISADDFLANGSDKLHDMLATHLEAAMGKAMPQVEIRFKDLSIAADVVVATKDGANELPTLANEAKKFCMSLAQSKNTFHKDILHPVSGVFKPATMTLLLGQPGSGKSSLMKMLAGRFPADRNVTINGSVTYNGVKSSEVKKKIPQLVSYISQRDYHFPQLTVRETMEFAHECCGGVVPQRVLDALASGTPEESARAKEIIEALYQVYPDIIVRQMGLTNCKDTIVGDAMTRGVSGGERKRVTIGEMEFGMKQVSLMDEISTGLDSAATFDIVKSQQSMAKSLKKTTVIALLQPSPEVFELFDNVMVMNEGYVMYHGPRAEVLEYFESFGFNCPPNRDVADFLLDLGTPQQHQYVATGNSSVPRYPSDFAALFEESSIYRNMMDHVDGPAHPLLLQDANKHMKETPQFQNDFKTSTMQLVRRQTKLLLRNTALVKTRAIMVVFMGLLYSTTFFQANPNVAQVRYGMIFQSILFLALGQVALLPSYFDAREIFYKQRSANFYRTLSFVLAQTISQIPFSAAEAVVFGSIIYWISGFVANAGAFFVYELILLMTNILFATWFFFIAVISPNLHVAKPLCLLSDFMFVLFAGFIIQINDIPDYLVWILWINPFSWALKALAVNQYLRPEFNVCSYDGVEYCATNGGKTMDIVQLELFRMPTSKAWIWYCVLYLIFLYFVIVAMALGTLEYIRYDNNHGNALSDEQRKDTEENYGVYVKMPPTPVASQGSDSVIVPVESFVPVTLAFKDLHYFVPNPIKGEPDLELLKGVSGYALPGTVTALMGSSGAGKTTLMDVIAGRKTGGKIVGDILLNGYKATDLAIRRCTGYCEQMDIHCESATFREALVFSSMLRQSSDIPTATKLAHAEECIRVLEMQNIADSIIRGSSVEQMKRLTIGVELAAAPSVLFLDEPTSGLDARSAKIIMTGIRKIASTGRTVVCTIHQPSKEVFEMFDSLLLLKRGGETVFFGDLGVNSSLLMDYFMRIPGTPEMAPGYNPATWMLEVIGAGVETKVTNTTDYVEVFQHSEEYKQLQAGLAIHTLPRADIPEMNYTSKRASSNYVQFTYLLQQFIRMYWRTPSYNYTRVLLSTFLAILLGITYLSVDYTTYSGVNGGVGMIFMTTFFVGFIAFNSILPLAAEEQASYYRERASQTYNALWYFVGSTLVEIPYAFASTFIFTIIFYPFVGFEGNVGDFFIYGTELTLFVLMNVYFGMLIVYATPRLDVAASMGVLFYSVFFLFMGFNPPLSQIPRGYRWLSTIMPPKYSLSVLVAQVFSKCENGHGMGCKPISNLPPSILADLGKTNVTVKEFTEFLFNMKYDNTANYTVVVIGLIVLFRLLGLLCLRYINHQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WEX3</accession>
    <name>A0A6G0WEX3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_015692</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000230">
        <property type="protein sequence ID" value="KAF0725922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WEX3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001668"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01100">
        <property type="entry name" value="APPLE_Factor_XI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000177">
        <property type="entry name" value="Apple"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14295">
        <property type="entry name" value="PAN_4"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026239376" description="Apple domain-containing protein" evidence="3">
        <location>
            <begin position="16"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="4">
        <location>
            <begin position="42"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="4">
        <location>
            <begin position="100"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="4">
        <location>
            <begin position="314"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0725922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="662" mass="72620" checksum="94C60F69D7EF0B42" modified="2020-08-12" version="1">MRFTHLASFLAVAAAANWGPIKEDVDFLLNNIIDPWTTPPQASNAEGCKPLCEADQRCSGFTWYQGSCWLKYGNPQLVAKAGARSAGMRPAECLPFEKNVDYWGNDIECIGGVTTPDACCNACTANPNCKLYVVSYQQCCLKTAVADRRPDQDPSLGIYAAFVRTSVIGGGPGVSISDGSYSPDVRVPNVKFSTAEGSQWLPGIQYEKAGAKPEFATIVEKVNTTVAAHQHGQPPNAKAILGTDGATIRGFWSVNSVGECAALISLHGASLFTYSPRDEMCLSHVYPTSSTTTYFLTSTGSFTGIKQTLPSTYQISTSTANSKSACQTTCTSNSYCTAYVLNGKQCTLYAPAQGKTGDDADDSVAGWINTAFSTKINSKLPTYGNNPSTVRFYTTAHQDDHELFMSNSYHEAITDSNTKVVFIYTSAGDAGIGQSWRLARQQGTVAATTAWVDHAGLFSSKKITDTVTVAGHHITRIKVGNVFHYFLCIREEPGNDESGVYQLGLLNLLYNGQAVPPMDLPNEIYYTRDDFADVLRGIYHLESDGVANVEIHSQDEQNGSGDHPLHLATGNLVQEVVDSDIWSTCADQVYYFDYDVFYWDVNLDEPVYSLQRYAWMWQSKAILDAYGEENWSVHAWNLGRTYPNHQYGKVEDCPTNKKKLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WFZ4</accession>
    <name>A0A6G0WFZ4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">endo-polygalacturonase</fullName>
            <ecNumber evidence="2">3.2.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ae201684_015535</name>
        <name evidence="15" type="ORF">Ae201684_015536</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(1,4-alpha-D-galacturonosyl)n+m + H2O = (1,4-alpha-D-galacturonosyl)n + (1,4-alpha-D-galacturonosyl)m.</text>
            <dbReference type="EC" id="3.2.1.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.15" evidence="2"/>
    <dbReference type="EMBL" id="VJMJ01000224">
        <property type="protein sequence ID" value="KAF0726132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VJMJ01000224">
        <property type="protein sequence ID" value="KAF0726133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WFZ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006993"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014188"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000002">
        <property type="entry name" value="Endopolygalacturonase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050434">
        <property type="entry name" value="Glycosyl_hydrlase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884:SF1">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033536824" description="endo-polygalacturonase" evidence="12">
        <location>
            <begin position="20"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="13">
        <location>
            <begin position="21"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="63"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="63"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF0726132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF0726133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="430" mass="44476" checksum="6A6F293AF951BFAF" modified="2020-08-12" version="1">MKVAIALAFAASSIATVVAQTPVAAYGQCGGSGYTGSTTCVQGYVCQVSSQWYSQCVPSGGTTAPTAKPTTKQPTPSTATPTTAPTKQPTPSTSVPTPAGCTLSGTYVSGTDVSSCSSVVISSLQVPVGVTLDLTKLKDGATVTFTGTTTFGTKLWDGPLILLTGTNLKVTGPGTLNGQGEWYWPQGQSVSRPVFFRLTHVDQSTLSGFTIHNSPYRTFSVLNSVNTLITGLTLDSKAGDSQAKNTDGFDLSRNTGVNITHNIIFNQDDCLAMQSSTNTLFAYNSCTGGHGISIGSIGGPAVDSSDTVNGLTVNNNKIIDNTNGLRIKTIIDLKGLVTNVKYIDNTLTNVKNAIVMHSDYSKAKGGYVGTPTSQVTISDITISGLTGTATNLYDVVANPSVVSNWNWSGINVQATSKGSCKGQPSGVTCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WH78</accession>
    <name>A0A6G0WH78_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Carbonic anhydrase</fullName>
            <ecNumber evidence="4 9">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_015264</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="4 9"/>
    <dbReference type="EMBL" id="VJMJ01000214">
        <property type="protein sequence ID" value="KAF0726496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WH78"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004934"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03124">
        <property type="entry name" value="alpha_CA_prokaryotic_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041891">
        <property type="entry name" value="Alpha_CA_prokaryot-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018338">
        <property type="entry name" value="Carbonic_anhydrase_a-class_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF265">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00162">
        <property type="entry name" value="ALPHA_CA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026376132" description="Carbonic anhydrase" evidence="9">
        <location>
            <begin position="20"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0726496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="231" mass="25440" checksum="563A9987A0573EBB" modified="2020-08-12" version="1">MRFFHAALFALVSLAAAKSKSTGKRQSPIDLPAPELTPAGDETVELTLSKSSAYLSHLGKTVQAAWDGGKKGKLVLNGEKYKALQLHFHMGSEHLVDGEQYALEMHIVHQNVDDPDQLAVIGVLFEESDEANPFLDQIFPALEDDEFVNGTQVDLGVIHGKSLDLTPGTVFYRYPGSLTTPPYSENVEWLVSAVIQPISTKQLEAYSTQFPKPTARDIQRLHGREVTLVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WHX0</accession>
    <name>A0A6G0WHX0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CBS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_015049</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000207">
        <property type="protein sequence ID" value="KAF0726793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WHX0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010309"/>
    <dbReference type="OrthoDB" id="418595at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051257">
        <property type="entry name" value="Diverse_CBS-Domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43080:SF2">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43080">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN CBSX3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="39"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="110"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0726793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="187" mass="20999" checksum="4B8ED84DF8A65C00" modified="2020-08-12" version="1">MRAFRQVLPSKLPRTAASLFVRPMSRQYHYEKGTAKDMMQKSCYFGVNFVISQDATVFEAITRMAGINLGCLAVSDDNNQFVGVVSERDYLKKVELQGLTAKETFVSQIMTQKARLVVAKANETPEQLMTKMLNSDVRHLPVVDNNNDIIGMLSIKDIVREVNREHQADLDTLANFSLGKGGHFVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WHX6</accession>
    <name>A0A6G0WHX6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WRKY19-like zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_015045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000207">
        <property type="protein sequence ID" value="KAF0726789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WHX6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003307"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056866">
        <property type="entry name" value="Znf_WRKY19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827:SF1">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24906">
        <property type="entry name" value="Zf_WRKY19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WRKY19-like zinc finger" evidence="2">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0726789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="247" mass="26762" checksum="CC6803D53199B716" modified="2020-08-12" version="1">MHGMLECADWKCIQEDGDFDIKIIDDALDFLHTSLPSFQAYMTLNASPTSVEEMLFTELLVMEPLQIKGRKVKELTLKVEPSTEGASYSCAIQGCQVKMNHPRGCCKKHGGKKLCGMDKCGNGAQKGGLCIRHGGGHRCRVDGCIKAAQTLGKCKSHGGGVRCSVPGCNKTSQGHKKCRVHGGGKRCCVVGCVKGVQKGGFCAAHSPEKHAVCPIHPHRVRSDDEASHSVSRTCPLHETTRRHRSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WI55</accession>
    <name>A0A6G0WI55_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_015009</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000205">
        <property type="protein sequence ID" value="KAF0726867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WI55"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019176"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0726867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="39573" checksum="E7BA2BBDB0C9BB94" modified="2020-08-12" version="1">MTRLMQVTQTYADRRRQAAREENLEMALGYLQAHPEDQRKKINPFAYVRSVLKRRSDALNVQLIDRERWINWLCGWNIPSTRPYFMDVTLREDDQSRQSGCVYVTHRTYNMSQRAYPYKPFGNQVDDLIDVEMHVREDDHGVCIQAFECHLQFTIFANYENVAKTWHFDFTESTPAFAVKAIEEMDDGILCVIHEHNEMKLKRIAVSGVFRGQDGQDRITITHTGIAVDDRFPFAPGEVRSNGFQWVVFEHVTDLITLVRWSLLNFRPVNADGPLPLRDIARSLHCPVSKNDSDELIVERIRRASHVGLEKLRDQFCQRCDRFKLEPFTMGSRDELFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WIS8</accession>
    <name>A0A6G0WIS8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_014765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000201">
        <property type="protein sequence ID" value="KAF0727128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WIS8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006384"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052050">
        <property type="entry name" value="SecEffector_AnkRepeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586:SF3">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140860">
        <property type="entry name" value="Pseudo ankyrin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0727128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="239" mass="26809" checksum="C9F1298803E04D43" modified="2020-08-12" version="1">MSPAASRDVVLSELLLPMICSYQKGIPIVMVPLRDACNVVKMVLEPIRNRPALRTDAPLDAIVAANESLANWYATHGLDHLDQLYTDMPGSHHVVLLHAALYGFVPVVQHEHKRIRGGLHNCPWYLIDVSAAGGQYHVLQYLDSIDYTGCTTAAMDHAAINNYPAIVEWLHKNRREGCSHRVLRGVVAARNPVMLQWLVHNRPEVIKGIDDAIMKAVQTQQEDVLDWLAHISRNRQLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJ17</accession>
    <name>A0A6G0WJ17_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PARG catalytic Macro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_014750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000200">
        <property type="protein sequence ID" value="KAF0727222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJ17"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000135"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004649">
        <property type="term" value="F:poly(ADP-ribose) glycohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990966">
        <property type="term" value="P:ATP generation from poly-ADP-D-ribose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009225">
        <property type="term" value="P:nucleotide-sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006282">
        <property type="term" value="P:regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046372">
        <property type="entry name" value="PARG_cat_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007724">
        <property type="entry name" value="Poly_GlycHdrlase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12837">
        <property type="entry name" value="POLY ADP-RIBOSE GLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12837:SF0">
        <property type="entry name" value="POLY(ADP-RIBOSE) GLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05028">
        <property type="entry name" value="PARG_cat_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PARG catalytic Macro" evidence="2">
        <location>
            <begin position="199"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR607724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0727222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="434" mass="48884" checksum="4CFA6CC573A79030" modified="2020-08-12" version="1">MAIIHESSAMSALQCAALQRTPSYPIGSFDDFAAYLDPKHKPEANGRRNFPALERAIQEFNTHFGYDFFTTLLPAIIEWAINVPESYPAESGLKFGAESEVSSSGEFIVWTCQYTSEVARFILANIFLLNTPTTVESAGSVDMFRVLQSNTMSIHGDVGSARVLSLLAYFHMQLRELDNPGRMITIERREWTGEIDPKDDWRTSKASLVPVELSVSSMESSSAKRFVNFANQNLHIHRIIPSATQEEVLFTCAPEAYIAIGLCARMQPNQVILIRNVQRYISYTGYLDTFRFADVLTPLPPPFDILSMDATVANHFTENIVHRDILKASLAFVDARPSAVSTGHWGCGVFGGNKTHKFIQQWIAASIRKGVTRLDYSVFGDTRLIGAWNQIIEAIRQRKWTIADVSKNLLLNYAKLNRSRREPYEQFVARVLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WKV9</accession>
    <name>A0A6G0WKV9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_014153</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000186">
        <property type="protein sequence ID" value="KAF0727889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WKV9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015181"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="5">
        <location>
            <begin position="273"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0727889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="329" mass="37523" checksum="38B2C5AA8D866435" modified="2020-08-12" version="1">MAELRFPISDEFFQLPTIQPAEIERYRAFGRQVAQELVDMAKLTNGHINWTKQSKTSTATLFESRVENLPAFLAESEILATVDKVIAVFQTTTMPTTRNLQRRFQPAVLDIVRLYNLTMPTADNSYLYQSLNWLIRDPPLLGAFLRRRDVSFIEHQEVIEIDGRRAYVLAKASIEIPGVHNLERDYNVVRSEYLHEGFIFAETDRPGVLKLLSVHHLRPNGSGNSAFGKFVMSHNVRFPIQSIEDVERLIRSHQLSQLTFVDQFSLPTVHTQSKCQVCSKAFGNGQKGHCRHCSRIVCVRPCSAEWDLVKGGLSFTVRICVLCSRQSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WMR3</accession>
    <name>A0A6G0WMR3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_013577</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000175">
        <property type="protein sequence ID" value="KAF0728618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WMR3"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0728618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="108" mass="11976" checksum="6F16FC5B4DDE2926" modified="2020-08-12" version="1">MEIHAPSFMDDLTTAQDEQMMDTIGECFVDVSLESADVQFVHGETTDLWSWPQIRKDESTYLCLSTISLSSQKSHIEKAGCQRFLRATAQAPGCESLDPTQLTASSDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WMY9</accession>
    <name>A0A6G0WMY9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_013667</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000175">
        <property type="protein sequence ID" value="KAF0728709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WMY9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013421"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053218">
        <property type="entry name" value="Pathogen-related_defense"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31723:SF10">
        <property type="entry name" value="PATHOGEN-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31723">
        <property type="entry name" value="PATHOGENESIS-RELATED FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="48"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0728709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="476" mass="53274" checksum="60807A7DF25AEF5C" modified="2020-08-12" version="1">MGRKTFSSTSLGQEPMRTSAHRSRSLKSPMGAGGSGANGSDAFERSKLVRHHGYLLKKALFRGLKAHYYSINYFSAKLQCFIDYNDFSLWNRQGQPPVGDKSPYRTYHVVAVDEDSMDQRKLILTIRKKADSSKVEKMVLSAESTEEFIDWINAFHDVLPRRNASFRENNNTFSCDDSGSGRLTVTRPDGTRYYPTTPPPRSAYDSPAPQGSPPSSRSRPGSRSGRASVYDGFKTVSTPDEHVIPRNLVLIGAANGSTVHVSDAKLAQAKYELSQLLQEPGTVRPFRGLSENDEQTDIEWLHGRPDFTLTDLAYLTGRSRWHDGQSLAARVETALRIFVMEVGHKPRVDQWNSIVTHTFTYQVNDLAPIAYYDMARLRHASLGLVAVPAERLHEVSDVFTSGFPLEVTTVFTTSPSIYFAWRQWGAFTGTYNGRKGNGQTIEVSGFGHMILDLDLVKMHSLHVFCDPHVLFDVLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WNA1</accession>
    <name>A0A6G0WNA1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA replication licensing factor MCM6</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ae201684_013389</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="VJMJ01000172">
        <property type="protein sequence ID" value="KAF0728819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WNA1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000465"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990518">
        <property type="term" value="F:single-stranded 3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902969">
        <property type="term" value="P:mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17757">
        <property type="entry name" value="MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000115">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008049">
        <property type="entry name" value="MCM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041024">
        <property type="entry name" value="Mcm6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF43">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18263">
        <property type="entry name" value="WHD_MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01662">
        <property type="entry name" value="MCMPROTEIN6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="14">
        <location>
            <begin position="339"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF0728819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="798" mass="89884" checksum="A8134F06B92BE6D3" modified="2020-08-12" version="1">MAGRRQQVGGAPEPQAPRIPLVIDEKAEVVKTRFLNHLRSEVSYEQQAELMRQTETSSLFVDYSRLFAADVDLAQALAVAYLRWEIPLRQAAAEFCATGRETFVCFYNFTMVRKIRQLRMQEIGKMNSFSGTATRTSEVRPELLFGAFTCVDCGGIVEGVEQQFRYMEPKKCANPFCGNTSQWELHPEKSVFVDWQKVRVQENSDEIPAGSMPRSIDVILRHENVEQAKAGDRVVFTGALIVVPDVSRFGKNGGDNVVSSRRGGENSSHGMEGEGVRGLKATGVKELTYKTAFLACSVQTMAQRFDRVSIRSEMGEETENDFTEDELEMIRLMKADSDRYIKMAKSLCPSVYGHDEIRKGILLMLFGGVHKTTTEGIKLRGDINICIVGDPSTAKSQFLKYIVQFLPRAIYTSGKVSSAAGLTASVSRDPDTGEYCVEAGALMLSDNGICCIDEFDKMDPMDQVAIHEAMEQQTISITKAGIQATLNARTSILAAANPQNGRYDKTKTLKYNVNISAPIMSRFDLFFVILDECNEVADEKIASHIVNLHKPLELQARDEFEQAYPEEALQKYIKFARTLNPVISPDAKRMMVACYRKLRENDVSSNGQSNIAYRITVRQLESMIRLSEALARIDLEETVQVSHVQEAYRLLNKSIIHVDTQNIDLDMPELPVEEKKNEDEQPQRQVDIESGSISFERFAVIQKALALFIREREDEMEAYKQTQADDVDMVTSGVLQGEVVTWYLSSQDITSESQLAVERKMIHSVIDKLLKDGFLQIVEDHENPQERFLTVHPNYAFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WNN1</accession>
    <name>A0A6G0WNN1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_013270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000170">
        <property type="protein sequence ID" value="KAF0728969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WNN1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004673"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0728969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="16355" checksum="D25653BC37DEC703" modified="2020-08-12" version="1">MESVLIQNGTIAQSDLTSGGAYSVFRRIFGPFGSVDLKRVQVPKSVLDFSLQFQDTLAQLRVGSYDFSNGILNLPTITTFAYFPPPWVNNPNITSTVGGNLLCNEVPAYGMTSGQLLLSGFTSSCGSILGDFITYSATSSLLATVALNMFTAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WP83</accession>
    <name>A0A6G0WP83_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_013157</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000167">
        <property type="protein sequence ID" value="KAF0729180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WP83"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013539"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="32"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0729180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="442" mass="49747" checksum="EEE6EA6AF84EF181" modified="2020-08-12" version="1">MMRRTLRGSQPPSILIKVQEESYYFKPCPEGISIGSDPTSDLRFVHDNKVERHHATLEHTPVCGVWVYVDHSVQGTFVNHRHHLQNEGIVVRDGDRFDIGNTVFFVQFQVPKVVPTAANAGPSTPRLTKKPSLAMMKPEYTNSPVPKHKRHVSAPTFNFDSIQENSEEVLAPSPRRIEKSPPPPPPPPSSTPPRVQTKAPISTRDDLRILVSKKMAHLVPKALPPGLTAMPMSPVPQAELRQQKELLQIQLAKKYKEDEWLHQQQREFLNRGSNTASRRSFTLDIQPPLSPTTHEIEEVLSSVGSSAPTEIAFYRQSLDSLDSDDDDGDVEDIAVISPSSYRSLDVSHLRHSFDALLSRQPKQQSPSQPLQLQPSRWQPNPPPNHVDDDRINNVRLKRHAHLAKTTPLLLHPLHSPYKAAKHRAFLDSPVGKASPTHFDYTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WPX2</accession>
    <name>A0A6G0WPX2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_012933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000164">
        <property type="protein sequence ID" value="KAF0729432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WPX2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008910"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF5">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="44"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0729432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="308" mass="33518" checksum="9A42FAE3A6C84927" modified="2020-08-12" version="1">MSSFLPSIVSSVGQHFVVTHHAALSTGIQVEYTLHGNPLAPHKLILVCGLAMPKEAFHPIVHAITTKAFDHVQILAFDNRGVGGSDAPWTGYSTHLLALDALALMDHLKWQTAHVFGTSLGGMIAMEMAHAAPSRVLSLSVAVTTAGYLQGTTSVMENLRCLAGVVAQMLMPKSGEERIRSLLRQLYPDSCLQDHSDLFFQYHAKRGGNAVAPLQGFIGHQLAVLCHNMSLDRLHAIRDAGFPILVVGAAQDVMMHPSHSHWLARAFEAPHTRFIQFQDAGHGVYTQCADALTNQLLMQFQLLPARSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WQ33</accession>
    <name>A0A6G0WQ33_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_012973</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000164">
        <property type="protein sequence ID" value="KAF0729475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WQ33"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010012"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052050">
        <property type="entry name" value="SecEffector_AnkRepeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586:SF3">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0729475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="385" mass="41836" checksum="19DD3AFF666A82A4" modified="2020-08-12" version="1">MTAVLHTSELLAATFAYQHGFAFSHLRLVKALRVCRRHQVALGYVSHDTWIATTPAYLREWLGQTSLTAFERLHGCDPDLFMIDDAARAGRLELVQFLHNHGAPCTVASMDCAAAQGYVEIVEFLTIHRPEGCTTEALDGAACRGHVDVVRYLHVHRNEGCTTRALDRAARNGHFQVVQYLSDHLAPSCCFSTALDIAAACGHFDIVQWLHPRTPRCSKAAVDGALVHGHVDIAKFLLMHRREGGSGDALVAAATANRCDILELLVHTAALDTTTALAAAAGRGHLEAVKLLISKAAFKSTAIRAAIQSGHVDVVKHLVQNDPMLGVDALVAAASTNKKDLLHVLVGLGGDDWLEPAWRLAKRHQVHTAIARLAPLRRETACRMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WRG0</accession>
    <name>A0A6G0WRG0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_012452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000157">
        <property type="protein sequence ID" value="KAF0730054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WRG0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004790"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026050050" evidence="1">
        <location>
            <begin position="20"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0730054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="153" mass="17953" checksum="6D37DABDE0A6D2D9" modified="2020-08-12" version="1">MKRHAIVMMVLVTIAICFAKTIDYDRLERQWEAGDHEDELLSDDELEYKRRGTLDKSEMVFVSLNEAVLRKRKPTDPAISVVSELCATWKQMLLQGGLTVNFYELEAYKVLAGMQHGSRVKELRDFFLEQDEVIEVTWDQNTLKKKRKRKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WRQ2</accession>
    <name>A0A6G0WRQ2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_012419</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000156">
        <property type="protein sequence ID" value="KAF0730125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WRQ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015311"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF124">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CHANNEL PYREXIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="42"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="75"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="108"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="141"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="174"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="207"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="240"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="273"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="307"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="341"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="374"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="407"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0730125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="465" mass="48979" checksum="4441B3954400F54B" modified="2020-08-12" version="1">MEFEQDLIGVDLYNAAGLGHFSTVKKLLNEGAPVNWRYEVEEGATPLILAAQNGFADVVKELLAHGADINQTMKAGATALNMASERGHLDVVKELLAHGAAVDKATLSGATPLFMAAKDGFEDVVDELLAHGAQVEARHERGATPLLVAAQNGHVGVIEKLIAYGASIESPHNGTTTPLIMASSGGHLDVVKLLLEHGADINATTESGTTSLFAASQLGLLEIVQELLKHGADVNLSMTSGSTPLIIAVEYNHMEVVKEILSHGTDIDATMDTGATALLIAAERGHLDVLKELFKSGASIDCVDEESGASPLHVAAQNGHLEVVQELLAHSAPINKVSSKSGSTALFIASQQGHADVVRELLNHGADVDLAIPGDISPLFMTSGYGHLEVIKLLVEFGANVDKPMESGATPLMFAAHSGNVQVLQVLLHAGANLSATANDGKSAWDYVQRDFHPEVITLFQQWQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WS60</accession>
    <name>A0A6G0WS60_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_012316</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000155">
        <property type="protein sequence ID" value="KAF0730318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WS60"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018375"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0730318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="244" mass="24658" checksum="E9A4E40D3CDB7A27" modified="2020-08-12" version="1">MKAYAGFPTADAPTDVPSPTATDALDDDTSVAPSEAPIDATTDAPTDASTSAETTNAPTDAPSPSATDALEDEASTDAPVASGLFEVSVVGDATYFVNETPCGGSGGSCPFAGNTTWKDCHDALPSYQSMGVCVAPWDAVCQVIGISGSGEQVRGCVWNKPAIAEQSVQTSQAAPVSSVNGSSNIVVYGLSGLALAVAIAAVVVATKKSPQPHAKKDQAVVKAAIDEEDNVVHVHSHSEVVLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WSR7</accession>
    <name>A0A6G0WSR7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyl transferase family 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_011961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000153">
        <property type="protein sequence ID" value="KAF0730538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WSR7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004764"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13692">
        <property type="entry name" value="Glyco_trans_1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0730538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="463" mass="53125" checksum="BED7A098B574EBF7" modified="2020-08-12" version="1">MKGKRQGAWMSLRNLIIGCVVVIVVFQAYVVFTTFNRGSTRTHLRSGNSHWWPDLLHLNRLNELCLTKGDTVISWKPQQQTEILTQDMDPEVLLAELRLCPEVDIFLPVGIRSHGYCEDAMAYVKFLKTRALPMWVFNMEFKDHNGKVYTYFDLCPSSAVMFMNHYWDGLDKKSTFPPQKKIVLMPNVEMYELGAQHYQRADYVIAKTKDGYRRITNWYKIKGNNMRNTQVIYAQHTTSDPTTTAAVKAQEDPKFGPIAPKNFETLSVFHANGRSTQKNTPKILDCWHDRPDMPMLHVYSNDEPSNTTYWNHFKKMTPLNLKYHNGEFIEPAQFGKLMAEASVILCPSITEGFGHYINQARAAGALVVTTDAVPMNEFIDVNSGVLVKNAVARPTHSKVLMGNDDTEFDVTPNDICAAMDEILAMTPQERAQKAREGQQRYFDQLQFFSDRMEDFRSTLRSNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WSY0</accession>
    <name>A0A6G0WSY0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TBC1 domain family member 31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ae201684_011960</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Molecular adapter which is involved in cilium biogenesis. Part of a functional complex including OFD1 a centriolar protein involved in cilium assembly. Could regulate the cAMP-dependent phosphorylation of OFD1, and its subsequent ubiquitination by PJA2 which ultimately leads to its proteasomal degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
            <location evidence="2">Centriolar satellite</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000153">
        <property type="protein sequence ID" value="KAF0730537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004765"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051570">
        <property type="entry name" value="TBC1_cilium_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853:SF1">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN 3 WDR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="14">
        <location>
            <begin position="395"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="849"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="893"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1146"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="668"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="1260"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="934"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1047"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1071"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1098"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1124"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1193"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1203"/>
            <end position="1217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF0730537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1329" mass="151680" checksum="43E34022907F54C6" modified="2020-08-12" version="1">MFGYARFRCVAFSAGDIFAAVDEKGRVFAFFPLRNRYALVCHLGTPALECAFSPQQRTELLVTCEDLTVRCVDVHSKTLVSTLRGHRQIPTCVAFQRPGQLALTASADAVIMWDSANWSRFRTLNAGPGVEAAQFVGNGELVAVCFKDDSILMWELSTLALHYRFTLPEYEHAPGLKRFCVSENCQVIVASGETPFIYVWEFESQTLIRIIELPATVQRIVEHIFVPLTSNIVGVLGDDGQLNFLNVTSKQPKVSLQIAHKIKAMTAFALDLHGKYLAACTSDGCLVLYDLDIARETAYKIQDIRQRADVDDLAFLPHRSALPNQSSQLMDSLFGAPFQKTNDEVLADPPQPQAAQPSVPMAAIHKTKKSRPYLNPQEYAVQHNRLQQLLGSYGRFPEKYRLLAWKYLLRLPENNATFEHLLAKGDHPAMLRLHETYPIQNQRLFRRLKRILSALAFWCPIYGEVQSVPALVFPFVKVCANNDLVAFEVVLSVLLHWGRDFVLQYPHPPRHQLLRLDQTLQERDPQLHAHFSSHQISPEDYGWSLVSTAFSEVLTRDDWLCLWDNLFAFWDKPSLLWAAVLAFLHQVRSTLLHASSSTAIQATFRQQQPIQTKHFIANLHSIEMTTLAKVVGDDDATKYFPLSLGQYPVFKRYPSFVVDYQIQERNRIASEEAAIEAKRNLLAQIESRTRELEQAHKKWMNDKAQVLEAEHRRRIESMQAEKTRLMEMNILHEQTKERRLKQIALMEQKAREALEESSKVLRAEHDRWMDELHMHMEKEKWRNQQQVDEEELVRLELDAERRVTELTKDREREERLQSMRIEFFAQLREQEIRDQMVFDAWKEEDRRAVAEQQSKRQQMESKQQEREEAKLRREWQAKFEEQRLQKERQMQLLAQDRSMRPNPTANNLDDAESEDYTNATNEYPPDRPSPPTPTSLTSQGDETPPLQAPSQQAPPHQPQQRTPPLQAPSPQAPPHLRQKRPGNTSQIEPTHAPPPQAREAHPHPAQVQSRTPAQISPPSPSVHVTPGVNSEPIDDVSARPQPPKTVSSEHRYYEGTRDIGDEVPPLVQDLPSPTTSYLSRQSLPQVPPMQARPHEAARQQSSFQQAPYQPIPQSLPNLSAPLQKDSKESSRISYKWSDRELLQHALGELSSDEDEGPVVRPRALPPSQQMSQLEQDLRAEFSDLSGSDGAESLEQRPLSELERDLEDLIGDDSDDDERSTSPRSSVDLKSLFAHVNQPPVQVSVPAPPPAPTTLPDRDRLTETTRKLLQLRSKLSDLETMAKQTVPVEVEEKLDAGASGDKAEHTKLLERAKELLQQHAARLRRETDHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WTS2</accession>
    <name>A0A6G0WTS2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Dolichol-phosphate mannosyltransferase subunit 1</fullName>
            <ecNumber evidence="16">2.4.1.83</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">Ae201684_011760</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15 16">Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a di-trans,poly-cis-dolichyl phosphate + GDP-alpha-D-mannose = a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + GDP</text>
            <dbReference type="Rhea" id="RHEA:21184"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 16">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 16">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.83" evidence="16"/>
    <dbReference type="EMBL" id="VJMJ01000149">
        <property type="protein sequence ID" value="KAF0730878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WTS2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012835"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000119">
        <property type="entry name" value="Dolichol-phosphate mannosyltransferase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398:SF1">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 16" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="18">
        <location>
            <begin position="16"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00053724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU365083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF0730878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="268" mass="29473" checksum="9B184D7A94474DA4" modified="2020-08-12" version="1">MADLRSRGAEGAVKASIVVPTYKECANLKELVTRVFKALGDSAKATEIIVVDDNSNDGSEDVIKSLAATGLNVRIIVRKTERGLSSAVLRGFEESKGSLLLCMDADLQHPPESVPQLIDAIDPEKGNAEFVIGTRYGSEGFSVDKDWPVYRQVISKGARLLARPLSGLSDPMTGFFGLPKAVAHRARKSEVNPVGFKIALELYVKCRVKKHAEVPIHFGVRVHGESKLSSKVIVSYLQHLVDLYNFAYPSLLWCIFIILFTIFLILFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WUR1</accession>
    <name>A0A6G0WUR1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="9">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ae201684_011504</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16 9">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="9"/>
    <dbReference type="EMBL" id="VJMJ01000146">
        <property type="protein sequence ID" value="KAF0731244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WUR1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011595"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051134">
        <property type="entry name" value="PPP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="11">
        <location>
            <begin position="29"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="12">
        <location>
            <begin position="184"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="799"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="858"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF0731244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="894" mass="102016" checksum="D5CA31CF56EAF2FA" modified="2020-08-12" version="1">MPTGDDSKVMSLLQCLLWPCFGDNMFASSVLAEGPLIKKGDYAHFRYFVLDTTGMLKYYEISLRQTINASGDVVFHIPSTKLTLTNQLSNRNLRGTMMLHPSFCARDLESPQGTSSTTRDFRSASSASNTPGSDMRCFRRSKEIHVTGFSPTGAIISWKLQASSIEHYDKWTRAFRIAMRPTWLPNSPFCQICRTNFQFFSPSRHCRKCGTCVCQSCSHMIDKLPLLAYTTPVPICIDCDPVPDSFDPQTKVLVYGMFPAIIVASVPPSSLTVEYLGRQSSAPTTVSVKYVERYSEMVLAANRIKCCLRAHVAYRLFRTQLHFHTWSLLETLQEQQTVKIVKIIRNTISVNELASLAPSYEERNDAAIDLDESLKQYRGVHLNFPLTENQVLKLSDSFRGGIALHGHYVTQLLDEVLARPPRGTMTHIQIPKGIELLIVGDLHGQYEDLMTIFDRKGVPSKTLWYLFNGDFVDRGLHGVEVICTLLAYSLLYPQFVFLNRGNHEASVLNRVFGFNEELKKKYPDFPNLFDKFEAVFNRLPLCTLIQDSVLVVHGGLPCEPNVTLKDIQAIDHLREIPTNRLESREDQIFSELMWNDPQPMDGKTASKRGCGFEFGPDITRHFCALNNLRLVIRSHESHEEGFEVMHDGLILSVFSASSYCGFQTNKGAYVVLTDELKPYVVQFHSQALQKFTSTRNWRTQANRFEERTLWSLRELIGKKHSELGAYFHTKPPQVSRLELKQGLVKVLGIPLYFLLYFHQLLPKNQRLVDTTKFLKANQLVLPTDHRWVDSTMQRIWSAMQETNVTKAFDYFDRSRKGRISFEDLKATLRVLGLMKPELPPSSPPLAPVLSQEDMAAFVNDQMAFELMHRWDTNQDGIVDMQEFQLAFSKQLNNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WUZ9</accession>
    <name>A0A6G0WUZ9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_011406</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000144">
        <property type="protein sequence ID" value="KAF0731343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WUZ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013709"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="5"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="38"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="100"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="133"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="166"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="263"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="296"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="329"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="362"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="395"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0731343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="449" mass="49817" checksum="1328B2A8CF8CCF81" modified="2020-08-12" version="1">MMDEYSNTPLHEASRRGHLSVVKKLLIKRSHIDMTDKFGRTPLQEASENGNLEVVKKLILAGANLEIADMVRILSLCTFFTYVVMELLDGGAKLEILDKSGRSPLHEASDNGHLDVLKSLLDRGARLDTTGRIGRSPLHEAAANGHLDVVKELLDRGAGHDMTGQNLSTPLHIASRNGHLEVVKVLLSRGASDFAQDKRGRTPLHETSGNGHLNVVRVLRERSVFLPTDMRGRSPLHEACANGHRNVVKDMLIVEKIDTADKFERTLLHEATRNGHVAIVKELLNRGALHHLQDKRGRAPLHEASSKGYLEVVNILLDRDATIDMPDKYGQTPLHHAADNGQSEIVKALLDRDAAIDLPDKYGRTPLHHASRNGYRDVVKKLVERGAAVDTRDDGGRTSLHFALESEHEEIVQILLDRGADMSLQTKVRYQVGNQYKNILGGQKSIRHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WV19</accession>
    <name>A0A6G0WV19_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucine-rich repeat-containing N-terminal plant-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_011382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000144">
        <property type="protein sequence ID" value="KAF0731319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WV19"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013686"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026296901" description="Leucine-rich repeat-containing N-terminal plant-type domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0731319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="34782" checksum="9567D1300CB9A842" modified="2020-08-12" version="1">MNFANVLLLALVAIAQASITLTTCTTSKGVSVPCLNDTATGNLTNLEPSSNQTYDFRNLNISAIQNLPADAQWVDLSNNQITQVLRGIPSKLTFLNLSHNALKTSWINVSIPVVTLDVSYNQGGLAWTPSNTWENFFPKVVRLLHRGNQLKSVSWNQDEWPIFHSVFRALDLSENPGMVVKAYETVTIFINTSVTLTADANSYEDTLKACGNKADRVVQYNITPVVSYSVQGDAVYGKPSPNQTFSVCKVTLGDLMGNSDPTTAAPSSAWCRQPKCSWGAHRIRIICSPGLWTLISFTPQRSSQAPPPLVSFRRSSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WV57</accession>
    <name>A0A6G0WV57_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_011422</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000144">
        <property type="protein sequence ID" value="KAF0731359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WV57"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008917"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0731359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="36558" checksum="F484C794EC41CF0A" modified="2020-08-12" version="1">MAMLPVDLMAKIVFFIPDSEDVFALLDILRPHIAFGPLGDLYQLGLTHDHSSLWPRLTLDCSMNDTLSIALYESIAKYYSHVLVNVSWYSIDWLKKHLNPTTTIEWMAQEFPVTLENIHDWADLPITRLYLFLESDTPQMWKKALPRMHHLKSLIIENSWGNIEDIYKIVAESAQITELEVNPNGFEVDNAELQHLIEWFHRQPVRVYADSFTNWKLLDYDLRQELCDVMFNCPTLDRLALTDCDLDDMDFSKFSFSMNTLQLYEFCLWKDDLKLLASRLKDSKLTHLELDGYLVGDDFYGMDSVDFWDYTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WVQ3</accession>
    <name>A0A6G0WVQ3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_011240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000141">
        <property type="protein sequence ID" value="KAF0731621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WVQ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014850"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0731621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="473" mass="55002" checksum="56C645F3C7DA676C" modified="2020-08-12" version="1">MDHCTERRVLVKRQRRHAETFNKLSSHTIAFMETLLNLPQCECQEAELVDSDAVSDSTDDTSSTYESLHLDSPYRHDDDLHLDSPIQQDDEETQVQVSSNSIFPQLSCRQMWMSWYHEDPQSGAQPHCALQVSDLDNDDARRQWWISKQFISKLTEVALQNDFISSKKALKKLSRRGLGSVFDRAFDVFTAESGENHCRLTPDSSCVEALKWMTQTRMNLEPPQEAARVLKDCEFPLLPCREMWWLWFIGKDLPHVVMYDSRRVMKLLYELAIKEKLVPSTDALNFMPEETLLDIFDVIFPIFVRSFKPEVQSAIRPDTLCRTVSNYIMRSKPRENQEPFVYAQVAGDFPSGTARELWRLWFHGDETSHGMPYRRTMWSRRHNYRTLTKHIMAKLEECAMDAGLVHSIAELEEMPKSALMDIFDKIFDDFVARNCPACPDSAYKMCTTLYNYMLSHRKAHHDLDVQESSIISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WWW0</accession>
    <name>A0A6G0WWW0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_010702</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000137">
        <property type="protein sequence ID" value="KAF0732049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WWW0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015190"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0732049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="376" mass="43585" checksum="E28908A81AE914C7" modified="2020-08-12" version="1">MDKLLQDHLDEVKKRHIQHGVPQTESQNLLEKEAAAKRLYCDPSFGHVEVVSIVSAYDECTIALQEKGKADFLEPLGWDFLPTNEVLATVRCVLWMFGLDSARATPTALWTKVWATWIVMNIDTHVSGWEWAASNEPVGLFTKPYDLSVTYLDNVMALLPSTYGVDDSDHTWQRMPAYLCLRNWVAATSAYLHMVTHCIPSFPIHGYMAMMTQPPKRTPKENLWYKGITDEGVPYYYHRHLKTIALDKPEDFDGENVVVPRTIEAQMIEHLVADPILRAEVEIRRVQIEVEKDEDNEWVECHDATTGERFYYSFQRYKLAFTRPASKNIIPAEKSAAYRCVLRLQAAYRMRLAKRVVHQKRQKTRKLPRFSSRNFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WX43</accession>
    <name>A0A6G0WX43_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Homoserine dehydrogenase</fullName>
            <ecNumber evidence="4 11">1.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ae201684_010796</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-homoserine + NADP(+) = L-aspartate 4-semialdehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the homoserine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.3" evidence="4 11"/>
    <dbReference type="EMBL" id="VJMJ01000137">
        <property type="protein sequence ID" value="KAF0732146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WX43"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001088"/>
    <dbReference type="OrthoDB" id="67851at2759"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00063"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004412">
        <property type="term" value="F:homoserine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000005">
        <property type="entry name" value="Homoserine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005106">
        <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016204">
        <property type="entry name" value="HDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001342">
        <property type="entry name" value="HDH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019811">
        <property type="entry name" value="HDH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004976">
        <property type="entry name" value="PRK06349.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43331">
        <property type="entry name" value="HOMOSERINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43331:SF1">
        <property type="entry name" value="HOMOSERINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03447">
        <property type="entry name" value="NAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000098">
        <property type="entry name" value="Homoser_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01042">
        <property type="entry name" value="HOMOSER_DHGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0521">NADP</keyword>
    <keyword evidence="9 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="13">
        <location>
            <begin position="352"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF0732146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="429" mass="45528" checksum="21BB9FE1798CC71A" modified="2020-08-12" version="1">MTIPLRIGLFGCGTVGGGVFQILNSRASFLKTIGVQASIEAICVRSPSKPELVELVKGHNTKITTKYDDILEDNSINCIIELMGGVTDAKDVVFKAIAKNKHVITANKALVASFMPELTDLLQAHPSVRFGYEASVCGGIPIIHTLQSSYSGDVIKEVAGIMNGTTNYMLSKMEKEGASYEAVLKEAQDLGFAEANPSADVDGFDVQAKIAILAKLGFGCVIKPSDIPTTGITRIKAVDFAYAQMMQSTIKLLGVAKRSNPASPNEISVFVSPIVVPVSNVIGTCGGAGNIVSIVSENCVNGAYVGQGAGRFPTANSVVNDIVRLGQELIPSSPFAATQAVTIQNDFSGKFYVRIRISDGLGIIRQVGEEAEKAGISIDSILQLPIQDRSNVDFVVTTDVTQLSKVQIMAKGIESLPFVLEAPLFMPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WZ69</accession>
    <name>A0A6G0WZ69_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_010186</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000128">
        <property type="protein sequence ID" value="KAF0732861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WZ69"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019617"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF214">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026359480" description="Protein kinase domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="286"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0732861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="559" mass="60238" checksum="6E543B0B44588D51" modified="2020-08-12" version="1">MKRRSVLHLAAVAAVVAGQVSCPKDTPCYDLTSKKCRRGNSSADNGDGLVYCDPQIGFCYDTAVCYGQGSGCVCTGKTPCLPLGGSCVAFTDACAPINAFMKWCPDSPPPPPLPSKPSPSSYSPSTDSSSNNPLAPLVTSPSPASPGSSDGSSSASPLDNSKPGNGKEGQGVGVIIGAAIYGAVVAIAIAVFFVHRSKLSRQDNDEPHHEDAIPTLGAPHELHKYSKDELKFSPRVPNVNTFTGSTRSGMTTASRSNASSGPSMASFGGQLDMYELEMYRIAPHDIAIVKMLAAGAYGEVLLAHFNGETVAAKRLLPGKKSNMRELIKFIDEIKLHSRIQCNFIVGFVGVSWIKPADVMMLTEYMDMGDLRGLLHESTPETFDWPHKIQCAYDIVQALVYLHTLDPSVIHRDLKSRNVLVNSEMVCKVTDFGVSREFEDMETMTAGIGTYRWTAPEVLQDGHYAASADIFSFGVVLSELDTHLLPYENMTNERGNAYTDTAIIAKVMAGQILPSFTPGCPKWFSDLGQKCMALSPQDRPTAMEVAYALQVELRKLMPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WZ99</accession>
    <name>A0A6G0WZ99_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Beta-glucosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_010214</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000128">
        <property type="protein sequence ID" value="KAF0732891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WZ99"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001922"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000099">
        <property type="entry name" value="Lactase-phlorizin hydrolase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="GH_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF36">
        <property type="entry name" value="LP05116P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026209494" description="Beta-glucosidase" evidence="5">
        <location>
            <begin position="26"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0732891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="562" mass="63208" checksum="CAC253A8FB947D77" modified="2020-08-12" version="1">MVMRRIVGWTALVVGGAASVASVAAKEGCFPNNFLFGTATAAYQVEGGWNLTDRTPSIWDDFCRQNDHVQCANVADDFIHRYPRDIAIMKDMGLSSFRFSISWSRVMHWNNASERMEPTRAGIAFYHALIDTLLAAKIVPIVTLYHWDLPSALHTHINGWLNASIVAHFNAYATLMFDEYGAKVPYWTTFNEPTSFILGGYGDGDNPPGISNSYTAAYMAAHHVLLSHATAVKTFRAKHIDGKIGIVLVSSMAFPLDPLRREDRDAAERKLQFNIGWYLNPIVHGDYPDIMKNRAGKHLPSFTHDESALLRGSYDLFMLNHYSSTLFTDCTSPRSKTPCYSLSRGWERDLGVDGSDPPGARPSSTNVHGEPICSWFNGYPRGYLTLIRWVHAFNRSAPILLTENGWCGNATIDNPDQLWYFQEYLKQVWQGIQEGIPIVGYTAWSFLDNYEWGSYGPRFGLFHVEYPPQIGSKDGFDPQPADLKRTPRPAALWFGQLAKTKCFPNAPKVINESTKFNQEKVDSKLTGILIFLMLLGFIAYKSNWRRNEGGVNEQTSLVARAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X0S3</accession>
    <name>A0A6G0X0S3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_009648</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000122">
        <property type="protein sequence ID" value="KAF0733401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X0S3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003753"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13999">
        <property type="entry name" value="STKc_MAP3K-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF214">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026211704" description="Protein kinase domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="245"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0733401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="528" mass="58370" checksum="0F96EEA53B96A151" modified="2020-08-12" version="1">MPSMKLVPWLIALAVGPIAASVSQGTCLSLTTASTPYWVITVNLLDSQSTVLTKACRATGDKTDCDTFPDEKSCNLALIKPAITVNITLDCDQLRALGSTTTSGLCPTVENDATSTKSTGKDTTSTKSSSVAYVGVAVGAFIVGCLVVFFIFRNRRDRGRRRLETEIVFGEHKPEVEPVHTRRSYVAQSTRTPRNEYTAHPPTLAASRTPRRSAFGQPTNEVDQVVGFQLDMGDLELWRIDEKDLTSHELIAKGANGEVWVGDYRGMIVAIKKSLPAGKSAKDVQKFIDEIKLFTKLDHPHVTKFIGVSWVRPREIELVMEFMENGDLRKYLETSKGVQGPGAFVWPEKVSIMCDVVEGLTYLHSVDIIHRDLKSRNVLLSADLAAKLSDFGISKELTNETMTQGVGTFRWTAPELIAGERYTVAADIYSFGVLISELDTHDVPYADYRNEKNQPLNDFQIMTLVRKGSIQPHFTHGCPDWIYDLALRCISLDPDLRPTGPEISHILRQQLKALSPEGNSNSISGMFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X341</accession>
    <name>A0A6G0X341_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_009074</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000117">
        <property type="protein sequence ID" value="KAF0734209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X341"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0734209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="99" mass="11153" checksum="3FECE6735A3D2A37" modified="2020-08-12" version="1">MLSYEVLIYQQPSHGGHPSIAQLLCKSPGQEGHERGLVSAEKHFLTILGEAEQVGRLVFQVMLLFREPKELFDLVLGRCRRDGDARGRCLGHLVVDERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X3F8</accession>
    <name>A0A6G0X3F8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_008869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000114">
        <property type="protein sequence ID" value="KAF0734409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X3F8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015018"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="186"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0734409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="281" mass="31697" checksum="F42E2925DA0CD7FF" modified="2020-08-12" version="1">MGSEQDAKFEDELLFEVEDQILMQRDEAKAIVSLARRAELELKEAEDMPNTDYRQGKNIDGQLTVKRKPTSREEVLLAIAPQRRLALTRARANSAPTELTLMANQAPDEIAPTEKRIISNLYQAVSTQAKVNARVQADVGTIGTQLVETATEIQTQIASTAFTQKQLEERLAIEFDIHKHHLEGMRSNTEAQIARLSDQLKTNEAKMSVDLDRLAINIDATLKKNQTLTRESISATSDNLYLEQKKQGDKIDEFMGRQEQQNQILLALIQQTAETQRQIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X4E3</accession>
    <name>A0A6G0X4E3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_008624</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000106">
        <property type="protein sequence ID" value="KAF0734775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X4E3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019550"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0734775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="267" mass="29571" checksum="62A35301CE8FCEC5" modified="2020-08-12" version="1">MSDDNAMAAMMKQYTESMQAQFGSMMDKFRTSMQQSVGMAQMMNNMMEQLVLQNLHVTCLVQPATPVTLHLELRNTGTIAIPVVSCTVTIHRRSPPTTQAEEEIAPLRTIPADLDVNGRSSHVIPLELPKVDQYNGQVVVSCVSPGTGLRLQKAYEFSVYLLQQGTIQAVTGAAPSFGGTFHTTTILDLQRLREVLRIAPADGVMRSSVGHYIARFPTLGIQFAMTIDFDENSKYGCYLHVHGAPNERFTPEDIAFEFETLARLQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X568</accession>
    <name>A0A6G0X568_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_008274</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000101">
        <property type="protein sequence ID" value="KAF0735059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003193"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007009">
        <property type="term" value="P:plasma membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd04037">
        <property type="entry name" value="C2E_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037724">
        <property type="entry name" value="C2E_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012968">
        <property type="entry name" value="FerIin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037721">
        <property type="entry name" value="Ferlin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12546">
        <property type="entry name" value="FER-1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12546:SF33">
        <property type="entry name" value="SPERM VESICLE FUSION PROTEIN FER-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM01202">
        <property type="entry name" value="FerI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="C2" evidence="7">
        <location>
            <begin position="20"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="7">
        <location>
            <begin position="220"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="7">
        <location>
            <begin position="387"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="7">
        <location>
            <begin position="747"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="7">
        <location>
            <begin position="1257"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="7">
        <location>
            <begin position="1417"/>
            <end position="1540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1041"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1543"/>
            <end position="1596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1062"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1558"/>
            <end position="1575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1576"/>
            <end position="1596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0735059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1769" mass="199726" checksum="0F6C89A6BFD31F83" modified="2020-08-12" version="1">MSQGAPVRPSAAPLPASEAPSIRLYESDDIPEATKPPNTLKITVVRARGVPTAALRSTTSLYCKLSCAGVEHKTKVKAKTLDPVWNETFMFRSPDLLTTCTIAVADKVNIKKRFVGQVRIVASDIAQEPIMRCTKFFSLLDKSWEAREKGLGELELKVSLVYERCHDAVVLGRATTTTEVSTEESEAAVVWDTGDGDGVAVQQDETEEEAALRKAELELQEKRRQEIIMSNVPKGDYQIQAHIIEARDLKGEYFDGTSDPICYVEILDKKQKTHAKSKTLACVFDEIMFFHFHNIGRDELEQASVNVTMYDRNVLRPNAVIGTYQFDLMSIYCRPRRELYRQWVALVDYKNKKDKGIQGFLMLSLAIVGPGESFPIHDNTTADPSSLAESPNMLLLPPTVEQSVHFLVVTVYVAEDLPPMDIHSIVSSIGIDAFVRVDFGGIKKCKTSIVTVKGARTLTAPFHEELWIPVMMPTMSRRITISVRDRDFGRSSEVVGTHSYDFRAVPQVNQDMNDPSNHVYLREVPLRYINLYGPPLKNVDAKAGEVLKKYPDHASTYRGRVLLSLAHITHPSKDCGDKFFLQEVEDEDWESLKPPTTRYVLRVALFAGQDLPHVRAKTGLAARLFVVVSIGPFEMRFEAQPNKQGFIAWNMTQEVKNIVLASDLTQLPDVIVTLCKEAAETDEPVGISFARLRGGEVVSRGMEPPVGWLNLHEEMARKGVIPAGQNPGSLLLRLAFGREEVAARQPWKNEPSVLSTTIPALVRVHIFQCKGLVYDTAKSKSALPDPQVHVHLNGVVKKTKARSRTLDPLYYESIQFETTIPLQVEYAGEVWIQAMDKSSSNKFIGEYRVALSKCTKASTVPYPTWVSLTKADLVEETVVAGKLLISVQYIEHPSLEDRSAPLPSIVPECREAYVDIVAMGVRNLKNSNLLHIQNPFVEFELSGLNASGESIVRRTKASHEPNSKNANFLERIVIPTRLPVDIMFAPQLALKVYDSTLAGLHQPLIASCVIDLTQKLPWSPTYEPPQQQEFDYHIDVAKQRNADKRRKKAKQAEAAADEADEANQRRDSEINDDAKSVKQDDGDDDDQPAHGREDSDNDEDIKIDEVSPPETHEDDGTGIGVLPLPQISFEATDESKEDPAVLSQVQQEENRRLYASMEDAKKKGRIFIASDPSGSLAAKTGEKDRSFDSPAYFHGRDWWIKLQGEELEDYLKTAPFESYSLFRAHTMIPSFFRKKKTKVQVQTGVFKGLVTVTLKPQKQNPLIDCVSLSDPQPYEVRVYVLKALNLQPKDRNGFSDPYLRLSLGKTKLNDRVNYKKKTLNPDFYKCYVFDTTIPGPSQLAIQVWDYDRIGTDDFIGETVIDLEDRWYHKAWQDIGFKHPKLDGSGCLKPIEHRHLWTGKESTSQGSLQLWVDILTPAQAALYEQVNIEPPPPQKFEVRLVIWRSEGITDRDMNRMNDLFVKAWMEGLKPLKTDTHWRCATGKGSWNYRLKFVVQMPMKPEFARLTIQMWDKDLTKWNDIIGEAQLDLYKWLYKAYMEKRTVRPFNEQSSERGGTSHDDESDEEEEEEDDGIDLEANEQKKPLLPGEADKSKTRKEGKLMRKLDQVLRKVKIKKPELTLEERKRRKEEKDNSEKDEAYQSILDMVGMGRLSDDSEWLEMRYTNREAGISESMGKLGVCLHIVPEAEYIATPVGSGREEPNINPYLPPPVGRIRFSTNPFTMLKELLGPEMCGKLACFVCCIGCTSFLALFGASIMSTLTFYEQLQSQKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X8A5</accession>
    <name>A0A6G0X8A5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_007205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X8A5"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0736182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="161" mass="17681" checksum="2F038704649C8A18" modified="2020-08-12" version="1">MQWTLQLSSDGTLGSRRVRDALAFEKCPLKCVDDLSSPAGGEWSAKEAAPDIELVRTERMPPHRSFDTDLDGCGLPARIVHSSSSWSPALSALEIASASSQSSMFQGFIQAMAEEEVETAAVAVFDFSPRQARWIPCVEDLTRRESFFSSAHALQLCWLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X8K9</accession>
    <name>A0A6G0X8K9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_007337</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C69 family. Secernin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X8K9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020388"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070004">
        <property type="term" value="F:cysteine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005322">
        <property type="entry name" value="Peptidase_C69"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12994:SF17">
        <property type="entry name" value="LD30995P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12994">
        <property type="entry name" value="SECERNIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03577">
        <property type="entry name" value="Peptidase_C69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="607"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0736317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="639" mass="70003" checksum="28CB45D5BF0E1251" modified="2020-08-12" version="1">MGAKDAFLHHFLMCAVHRIVSTAVLLASSSVACTIIAVGKMASATGSPMVVHSADCGNCDFRLGKVPAKTFSPGAKRDVVQFRLEYPRYVGDDRGDVFTLANTDTSIFNWTNTPSIGQISQVNDTFAYIGAHYGIMNEHQVSMAESTCGGRLVSKPVSDGGKALFDVSELTHIAMERATTARQAIEIMGDLAEKHGYYGATWSGPGAAMSSGEALAVADTNEVWLFHIHPDDTGASAVWVAQRVPDNDIAAIANQFVIHHINLTDRDNFMGSANLVDVAVRAKLYSPQPNEAFDFTKAYAHPIQPDQYYATRRVWRILTLGNPSLKLSPITDIFASDYPISTPVAAPISPTTLLSFLRDHFEGTAFDMTNGLDAGPFGDPDRFDIHANGNMTKETATKGHFERAISIFRSSYSFVTVANGAHPDVGYILFGQYGPHAATYVPIYAKIDKIPMRYSRGSLHRFDPNSNFWTFAIVGNWAARFYTHTRPVVAAVQAQLEASIMEKQATIVAEAQHVIKSQGDQGLRMFLTTTSEAFAETAHESFTELFAHLVTTFHDGYHMQNLSGSTLSAQSLFYPEWWLKNVGYFDKDKVDDTTATFITSNEEASTMLYVGMALLGAFVCVGVGFGVGMYRRQGYHEIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X9M2</accession>
    <name>A0A6G0X9M2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_007121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000088">
        <property type="protein sequence ID" value="KAF0736671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X9M2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004066"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070652">
        <property type="term" value="C:HAUS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029327">
        <property type="entry name" value="HAUS4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16219">
        <property type="entry name" value="AUGMIN SUBUNIT 4 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16219:SF1">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14735">
        <property type="entry name" value="HAUS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="219"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0736671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="290" mass="32890" checksum="819458F64A4DD381" modified="2020-08-12" version="1">MEAHMRAKLLLHELKHVVAIETTEQGTSNFKAMAKTLLAVNQTQHSVSNMAPGTTRFGLTPDSVRETWGVDDTEKLGMMKEAMRVLLPPDIESRLEAKCRLICNFVYPQNDANGACLAFSHVHQLPKELSELRDNVAEMAAERYTIEAACDQGQIEYIRLLTEISKHLVAIIKVHKIDMYTQYTRPKVEFLQACVSALQRKIELMTKQLLVETYSVKKLQALSSLRQLLEERHRQATATRAELLAALRARDSTDDLLDIRQDYARTQHGILKARTALAKTRDESMSSRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XA95</accession>
    <name>A0A6G0XA95_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_006788</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000085">
        <property type="protein sequence ID" value="KAF0736976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XA95"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010829"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0736976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="95" mass="10777" checksum="7D0E23A26206E7D7" modified="2020-08-12" version="1">MASQIRRALDPDTDESVDVVAEGQPTLAQRALLGKKKAKKMRIEHERGMSSTAQLARIADATEKKNGFTKEHIMMEVFKIDPDSEESKRFFSLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XAK8</accession>
    <name>A0A6G0XAK8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_006821</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000085">
        <property type="protein sequence ID" value="KAF0737010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XAK8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005165"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF18">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="18"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0737010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="360" mass="38553" checksum="98613D04A0A6C13D" modified="2020-08-12" version="1">MTAIPTKMRALVQVKRIKTLDRAELETCFELQTVDVPVPKAGQVLVKVESAAVNPANLSALQGLYATSAAASLPTLIGTEGSGTVVAVGSGWWPWWLNGKRVATLASGMWAEYVVAEAQKCVVLPDDVSFEAGTSCFVNPLTSMSFVQIAQANNAKTIVHTAAASALGTSVVAGIVIFMDSVGKMLVRYAAQFNIQVIGVVRSQEQVEALHGIGAKYVVNTSTEGWQDELTNLCNELNASIGFDCVGGELPGQVQACMPAKSELFVYGNLTGQPWANFSPGDIRFNNKKITGFFLFNYLSQQGSLGMFTMLGNVTKGIKTTFATTVNASYPLDDADDAIVAYTSHMTNNKIVFKPQEKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XBA4</accession>
    <name>A0A6G0XBA4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_006538</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XBA4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021739"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000285">
        <property type="term" value="F:1-phosphatidylinositol-3-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046488">
        <property type="term" value="P:phosphatidylinositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17300">
        <property type="entry name" value="PIPKc_PIKfyve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044769">
        <property type="entry name" value="PIKfyve_PIPKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="193"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="PIPK" evidence="6">
        <location>
            <begin position="548"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="447"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="495"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0737370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="908" mass="103506" checksum="1B69EFD79CA79A28" modified="2020-08-12" version="1">MSNDHAVKKTLTNNADICVVVPPAVEEEVFEIQVLHPYKLPLGWRPASHPWRNRAGDEPDTAFCKFPPSFDPTSASDSMVDGMKDVWRWSTPWTVDTTYTLCDEEGWTYGISIASLNNHIAEGTSKTKPRPFDFLRRRRWIRTRIKVQPAEYDDETASRSYSVLRLDSALAHVVYGRTTPLRQMLNLKFNPKDIAMEGWLGKFGHFSHNWRLRYFLLRRDTNTLIYLKDTSSMLQLGQVPITTHTTIEAVAPLTNKTRLQFAFELVNGNHRCRLNAPSEAVKQQWINAIHDIMFKRQPPFALKVSTSQRLRPNYRAECVLPHLTALQDLFTTASAFILSVFDDLFNHGADLSESNAKIQSILKPLSTSPSSAVSTFRAEVVASLDAISAQHIQPLRNLALLSFLKILQAKEAVYDECMSLLDSIWSYQPPESKAVVKLRRTSSDRRRQALPEMWLQQEDRPQRPSITDNSSEPCSEEATTSDRSLTDVAVLGPKGGRKSSKQSLRRVFGRPEHLERGVDGIIIWANDKDIGSLIAYTLTSKMYVERLEDRCKAINVLMELEDKMIARSRNIYKEIRSKAIHHLKCHVVLNSRTDENDSRESEVDEDEADCTTVTVYFAPQFHCLRHVLQPGNLGYLDSIAQSASWETTGGKSGAFFLLTHDRQFVLKGVTATEFNMFVDLAPSYFDYMASVAENKKPSCLAKILGAYKIKLHGHSKAMYVFAMECSTFGFTTTQMYDLKGVKRNRDVEQPSARRAVLPDENFIDRVPVQVRENDWRRFSMALENDVKFLASCGVIDYSLLLAFNDETLEIRAALIDYVHQFDFLKRVESGAKKMYQLPTVIPPEPYMERFLKAMEKYFLSRQVDEDDDEEAVVTRCLSDTVLQSPSKRIRPRMLSDGSSRRLLKAIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XC72</accession>
    <name>A0A6G0XC72_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_006243</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000081">
        <property type="protein sequence ID" value="KAF0737749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XC72"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012798"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0737749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="618" mass="70737" checksum="DEDDD8E7093F9E7B" modified="2020-08-12" version="1">MSRELSFARTTCECKEPLFSYKYLRCFPHCCPIHSYGNFCSASIDLVASNVDHAMHDVYAFARFQGAQEHVFQPDEIVPATMFLSSLRTPGDLKGEWLPSSSSAYNQSKKEMIFRLNENNSLGWHYGWVGSSTQAHRACLHYLVGYVVRHVSPNDTSKFQIVMSTASPPFIIMSYRRACYYCQKHRANAITNAKTECECEGEFNYKRSLTNYSSMNLNLAQSNENSTNPLTMERHLTILYAFLSMPSVHFFASQLQTLENRILKSLLQPMGASMTFNAYQRRSMPFPTSIVRPGVVLFGPVNTDLESLKAFCVDMAMSALTFGSLQQIAKFFSDNTVHLFERDSLYEAYIDWVRQTHRSMSTRLLPLSMTMGQLVSHLIVAATQISELKPVQGFLQHLDDSTDEHSLGFNYFVAQLREVFMAEETKPIAPLSLSERWMYDKTISTMYEESVPPSLDFSLATMFRCLTMAYSFQMYTDSHILWLKSDLNAFNTVWSEFYLDYEPRVFRVFPNGESSMVHLSGLYHGDYVGHLNLHDNSLVLELFSWPTSPSLRYALRVTILFQRVKEHVMELSITVARSEVGGTIDFSLLSATERYAEYNRDKEVVLASFAISYNRIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XCT8</accession>
    <name>A0A6G0XCT8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein WDR12 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_006015</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat WDR12/YTM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0738023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XCT8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009899"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03029">
        <property type="entry name" value="WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012972">
        <property type="entry name" value="NLE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028599">
        <property type="entry name" value="WDR12/Ytm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855:SF11">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855">
        <property type="entry name" value="WD40 REPEAT PROTEIN 12, 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08154">
        <property type="entry name" value="NLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NLE" evidence="9">
        <location>
            <begin position="7"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="135"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="178"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="239"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="327"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0738023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="406" mass="44057" checksum="C949E77B8ADA738E" modified="2020-08-12" version="1">MSDGAQIRVKFVTKNPAIRVTETPFAVPIKLARAGLSQVVNHLLNTTTPKPFDFLIDNQFLRTTLEKYIVNNSLTDEAVLTLEYVEAEVEPQENQTQNHPDWISAVASSREVVVTSCYDGILRVFSKSGEPLSQVKAHDSVIKSIAIYDDIIVTGAKDQSAKVWKIDEDHSVHPVSACIGHLNSVDAVAVSGDQVLTGSWDNTVRVWTTGASETDTKRKKTSESSKQSTMTEQEAKIVLPGHTAAVLAVAFDSTQSHIAYSASMDRSIKLWDLTTQQCTQTMVGSSTLSDISVSSAGTVLSAHPDNAIRLWDPRAAKSGTSLVQATFQSHKQWVSAVEWSPSQAHQFVSCGYDGAVKLWDSRSSIPLFTLAAHTGKALDVAWLSNAKPAFASGGEDCQLKFYATGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XDC0</accession>
    <name>A0A6G0XDC0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">COMM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_006048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0738057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XDC0"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017920">
        <property type="entry name" value="COMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037361">
        <property type="entry name" value="COMMD10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12333">
        <property type="entry name" value="COMM DOMAIN CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12333:SF0">
        <property type="entry name" value="COMM DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07258">
        <property type="entry name" value="COMM_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21672">
        <property type="entry name" value="COMM_HN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51269">
        <property type="entry name" value="COMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COMM" evidence="1">
        <location>
            <begin position="128"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0738057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="193" mass="21562" checksum="5B181D332BED2B6D" modified="2020-08-12" version="1">MSSTSLVDNANAVPLINAFPQDKLSHLVRRILQAPHQTNGGFNSEEQQQLMEMGHMSPAQMQSFIDTLEHTFARAGSDDWDDRQVLDSLTSTGISDKVANIIASAWTQERASYRAMLLEQSTTNQLPNVTESHWRMHVTIADSQSTGQAIPTALFNLRTNDNSECHMEMNHSELLQFLIQLDAIQARLDTLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XF21</accession>
    <name>A0A6G0XF21_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyrroline-5-carboxylate reductase catalytic N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_005466</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000070">
        <property type="protein sequence ID" value="KAF0738856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XF21"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004310"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645:SF58">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="2">
        <location>
            <begin position="158"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0738856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="374" mass="41072" checksum="67BCA37CD5C0DE99" modified="2020-08-12" version="1">MGPKLWPCLKDIKSSPQRNLKADDHSVIMQQFTANIPSYEKCHQAQSAVKGKVQQRAKCILEPWIMSIERRTMTVSSRNYSRRSHSDDSMALNNASIDYDNEINKLDPNLFGPERLSNRMRPLYYGRAIVLRVIADQCLYFALLVHKLRQAAGHSTTKIGILGGGSVGVEIAQTFLRACWPPNDLVISTRQPNDTRWMSRVDSAVPRYYDNVKLADESDVVILAMPPAQLTSVGIQVKPTLSSKRTVVVSVLAGVGCDRVRKVCGSSYTLQTRMANQVDDCALEQFAHDNSSGLHALCLVFEAYASALGLSPARQVAVDLVLGTHENQQPLDAPGEKVTAIAGAAAAAPSVWQDALVQAQRTFSRAINQLDVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XGA8</accession>
    <name>A0A6G0XGA8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_005046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000065">
        <property type="protein sequence ID" value="KAF0739269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XGA8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003734"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0739269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="271" mass="30220" checksum="3FC0423BBEEE3F6E" modified="2020-08-12" version="1">MKARPEERVQDEDLPCECKATGRLKKPHQLKRSVALMVESEIPVVSADEQHEETPCGVASRSSTKDREPQDGFNTGRIVEESPTTRVQDEEMARKQNDSPDPPKFMAPSCFLRRSMDIQHKASSSPHLLKRRDIISFVKTASPDNAGQDQAQINIQSNGKCMERPHQLNRSENFVAANPRDGPCQDESELQVQTNKMKIIPAGGSTLADDSAKSALTFSSPGSIKPQIKRSNARVEQLPVHQMNDCARSSHLALYRAKWESRIKHKAILSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XGU1</accession>
    <name>A0A6G0XGU1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_005001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="VJMJ01000064">
        <property type="protein sequence ID" value="KAF0739435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XGU1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017055"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000594">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF83">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE DHX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="288"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="474"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0739435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="921" mass="105830" checksum="9184BAB65C5E1876" modified="2020-08-12" version="1">MKPEKRKQRRTHEEDDESEYEVGAALSAYRKQKEQKQEEEEVDEDQVAKQAFEDRLRAKDEDYRNRRKKQRQETLDADEIRELATRGTVSDKQRDERLEAIKLASRRKYLEMREEKLKKLVEGSIKDERLLFGDENLTEKERKRLELNETILKIQKDREKGDKVLGYQIPDASDQNDENGERLVKKDELYDNDEVEETKTEQERWEETQLKIATRQGLYGAKDRAPEETFEYEFDDQIEFISQRIMAGENVSPQDIKDAKKLAEEHKHLDMQESRKRLPIYAYRDVLLEAVRDHQVIIMVGETGSGKTTQVPQYLHEVGYSELGKIGCTQPRRVAAMSVSARVAQEMGVKLGNEVGYSIRFEDCTSDKTVIKYMTDGMLLREFLTEPDLKSYSVMIIDEAHERTLQTDILFGLIKDIARYREDLKIIIASATLDAEKFSTYFDDAPIVKIPGRMFPVDILYTRAPEADYLDAAIVTALQIHITQPLGDILIFLTGQEEIETAEEMLLYRTRGLGSRIRELLIRPIYATLPSERQAQVFEPTPPNARKVVIGTNIAETSLTIPGICYVIDAGFCKQTNYNPHTGMESLLVMPISQAMANQRAGRAGRTQPGKCFRLYTAWSYQNELDETTVPEIQRTNLTTTVLLMKSLGINDLLHFDFMDPPPEKSLIRALEQLYALSALNDRGELTKLGRRMAEFPLDPMMSKALLASEKYGVVEQVLTVCAMLSVNNTIFYRPKDKAVHADNARLNFARGGGGDHIALMNVYNQWVETQYSTQWTYENYIIGRALKTARDIREQLAALCDRVEIEKSSNEQNTEAVRKSICAGYFYNTAKLDSSGSYKTIKQTHTVAIHPSSVLVKLEEMPRWVVYHELAFTTKEYMRSVIPIKPEWLIEIAPHYYKAREVEDSTNKKMPKLVGRAQAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XI56</accession>
    <name>A0A6G0XI56_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_004469</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000055">
        <property type="protein sequence ID" value="KAF0740025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XI56"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020212"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01100">
        <property type="entry name" value="APPLE_Factor_XI_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000177">
        <property type="entry name" value="Apple"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33946">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33946:SF4">
        <property type="entry name" value="COAGULATION FACTOR XI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14295">
        <property type="entry name" value="PAN_4"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00223">
        <property type="entry name" value="APPLE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Apple" evidence="4">
        <location>
            <begin position="115"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="282"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="295"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0740025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="513" mass="54859" checksum="EACB91256F968188" modified="2020-08-12" version="1">MLSPHTPPPRGAYKQIPLSAKQCVLAASEAGGCCCCELDILSISMRASRHVRYNCSCSSSVKASAEDCCGHCTADANCKAFSHYLGVCYLKSAKGNPISKTGVRSAAIALPVSQCSAIEDDVDYSGPDLRSVDATAAEDCCAVCAQDSQCKAFSHYLGVCYLKAAKGDPIHKRGVRSAAVAESPSDSQCSSIQNDIDFSGGDLVTIPSALAEDCCAICKDTSGCKLLSHADGKCYLKNEIGRRISKAGVRSALVLTAVTTVAPTPAPALPTVAPTPVATTIAPSPAPTSSPTPVVPTTTATPRPTSACNEKRQRRSWSSLSTDDKELYLSAIEDAMRLGHYKEFISAHMDKNSNSHGYGSCGYFFWHRKFLLAFENMLRSLDPKYACLTLSYWDFTEDYAKSEQGKCKTITECCPVTLDMGGSTPGTLMSDNEVWVTTRPIKAFKDGGSGIARGKWHEMTMPKWSLKTVRAALFGSSSIANVSHLIETTIDSSVRKTLRGTFEVNLAAPKEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJ91</accession>
    <name>A0A6G0XJ91_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_004253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000053">
        <property type="protein sequence ID" value="KAF0740249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJ91"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016757"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="9"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0740249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="299" mass="32818" checksum="22E8201B6F77C765" modified="2020-08-12" version="1">MIHPVVARVSSRLLREGPPTSSGPQSTSTAPPIDVEIMPVTDKHGRQLISANDLYAHANERTDDIACREKIDALATRRESFRGSTIGLRTPPTEPLPRPRPIKHIPPLAMVEPHVDQPNEPRAQSPEPLALPDITEDALAQLTAQTEMEIQISPPRQDLKALDTYDRDKTLLHHDPLPSSCLSGSLLQSPTMSFKWDATPVTSSTDCARSTSPPKADVPSQRRYSQTARSDDCVRHDGVLETHDGGLVVYLPLLAAPQPLSTRRRLVLHCPLQSLPGQEVRRKAFSNDNPVNESLHGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJH4</accession>
    <name>A0A6G0XJH4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_004272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000053">
        <property type="protein sequence ID" value="KAF0740271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJH4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006824"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0740271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="168" mass="18519" checksum="757D2B39CC1C7BBA" modified="2020-08-12" version="1">MPSPPVFQPAMTISPSTKVLSALTLIEKVSSRDILSQSKLPQVTTATTDDGLLLKKTFKTQVPLTGARPFDNLTVDVEVVQDDVSGTYYCLTKWHGKSGVGHYQLEGPCSLKEAHEVFTGMNPSNEKFNTFWSTSIRVAVEGSRRFIRGYFMGKEEGEPIVFPTQVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJT2</accession>
    <name>A0A6G0XJT2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PIPK domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_004000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000048">
        <property type="protein sequence ID" value="KAF0740625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJT2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009202"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00139">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF8">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 5-PHOSPHATE 4-KINASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="PIPK" evidence="4">
        <location>
            <begin position="288"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="638"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="638"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0740625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="707" mass="79873" checksum="BF771FE7DA9148FC" modified="2020-08-12" version="1">MVDADVVWQVLLLTTSTAILSTTLVFFVRFPKTRAHPGPVLISLIVSSCLGTLFRAAMFLTAPDELSWVCVGQAPDHHTNTTLVLFWLSLYFLSASTFWYLMLAMDLISSLSNPFLPFQSNSLIHHSLAWPLAGAWCLFYDLTLYNQHRVPTVHLRILAVLPLYAVLLYVVAALRAAWAKSRQLDTNAHETTRRMAKLISPYLVVFGATGVILLVVYLAEVGRNAPTVYSLYVDQLTGIIAVIALFVLFYFDSGVGLCRARSQTLPTLASPQPAYTMQNDRVASSDFDVDIAADLRKMIMVLTRMGIVSAAARDPTDLVTGRLPRPEDFSVIERKRITFFGTTPNSMADDLVFEDVAPAVFHSLREFCGIDHKMYLNAFNPDENLKEICSEGRSGNIFYFTANKQFMVKSVPKEEFDVLRSILPAYYNYMLDHRRSFLCRYFGCHSITLPVGTRRMYFVVMANLFHEGPVDQRYDLKGNTDRRQAIATTEVELIMRQTVQRRAVDKLMLDIDFSRIHQCILLADADATATKDQLKRDINFLVDQHIMDYSILVGVRHLHEGAPRQSAAVISRDGTNLYNMGIIDMLQRYNWRWTVQRWFLGSVLCKDTSQVSAVPPVQYGQRLINFIRQDMFNQTRRQSRSSAFSSSTQPSGQYTTTSEGGFPLTHRPSGFEPFAGNEATSEATEMWLATNLSDEISDIDCAILQEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XLX5</accession>
    <name>A0A6G0XLX5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_003475</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Putative oxidoreductase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000037">
        <property type="protein sequence ID" value="KAF0741365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XLX5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010593"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44196">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44196:SF1">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0741365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="27106" checksum="F0193FA292AAD313" modified="2020-08-12" version="1">MDSMSGHTVVFTGGASGIGLALAIRFLQSGNKVILVGRRANKLNEAKAAHPDFHTVVGDMTTPESREALFLLLTTQHPDIDVFVHNAGIQRAVDLKEGLVSDWKTVSSEIDINYAGVIHMTMLWIPHFLKKPFAAFITVTSGLSFAPLANVPVYSSTKAALHSFTWSLRYQLADTPIKVIEILPPAVDTDLQAPGLHTFGVNVDEFADAVYGRLSAGEDEIGYGLAETGRVAFRNAFGDSFVAMSDHFMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XLY6</accession>
    <name>A0A6G0XLY6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_003157</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000036">
        <property type="protein sequence ID" value="KAF0741472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XLY6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004517"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008506">
        <property type="term" value="F:sucrose:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432:SF26">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13347">
        <property type="entry name" value="MFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="453"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0741472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="482" mass="52283" checksum="D95D31682C338F04" modified="2020-08-12" version="1">MASHIQDAAAPVTPNDVDYVEKDADGLDVVDKSQQEGMSIPMMFLVCCPKMAMNMAWAAQWAAFGPLLQVLLSYSSVQGVQIVGPVSGLLVAPFIGVLSDSTTSKYGRRKPWLFWGAITSIMCWAVMMNARDIGDALGDTGDDNRPWTTVFVVFCYVWMDITCNLTQVPVVLLIADLAGNRQVTAASIGQGWSIAGSLVVSGYISFFGPAHKSIKPFMGMLMVIMFVCCMSVCWFVKEEQYIPAVKPDTKQQLKDAFSALYVGLRKLPKVLALYALIFLLLQYGYTAYNGAKGQFFGIRVKDGLATGADTCGTGSNPACTDRQNAFNDGVRLAGGVTDTIFNLFGWAYLACMPFLVRKIGAKWVIVMACVPQVLLIVMAFCKVVVIDVIIVILTSIPQQTIFALQLPLIVYQIGLAPDNNLGMYAGAFNSANCAGQFLNFALATQLVKTSMTFALPVLVGGILSTVALIIAIFFFKLDMKTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XMW2</accession>
    <name>A0A6G0XMW2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_003230</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000036">
        <property type="protein sequence ID" value="KAF0741548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XMW2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021885"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF600">
        <property type="entry name" value="PDGF- AND VEGF-RECEPTOR RELATED, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="451"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="171"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="171"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0741548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="713" mass="79576" checksum="66EBBB68A3B96C5B" modified="2020-08-12" version="1">MHLGGYTETQLHDRAYALLNALHQLHSKSIAHGNLTFDSIYIHRGQLVLHVPPKPDHHIEFPATAANKANDIFAFGILLYMLATGRHPFATTESTSSSQVLCNMDHPSFQVDIVALQHLAPSAQSVILDCLARPESRRPTTEELLKRDWFRVRLTMTSTFANPLNRTTAETTESYVSIPGRSSSRGVRKRLSGSTTFVPAATGATPSSPDEDSMSDPVYHQFSNYSAPPPPPYASFNYPSNESFSKDLAASLLVAPSPATMSLLPSERTHKSRSVFRHVKSEPDLPSMSNRPVVFSAYGPPTIPADNKCRVFIWAYLAHQIDEIRELAAAQNTIETGRLSKSLYVSIGKVITISLEPPKGWRLVGEQAKSFHWIEDIERVFFDVAVDENASEWSFLCRARIVVGTHVALLHFALPAIDHNNAKLEKDQVEYSSTYERLAPVESPMIAREDLTILEPVGSGFFGTAYRAIHRPTNKEVVVKTLRQDIDISMDEFEHEVKALTMIGNHPHVVDFIGACDDGNSLSLVMEYVPNGSLQSLLYQSNNYETYMRTIFARDAAHGILNIHQGHFLHRDIAARNCLVDADYHVKVCDFGLSRPVDRVMGHLLDPISAGPLKWMAPESLELPHVFSTASDTYMFGVLLFEIMMGKEPFPSLPPHEAAALVLEGHRLTLKEWNECPPTHQELLDQCFKLDPHDRPTMAHVAATLDDWLTQHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XN03</accession>
    <name>A0A6G0XN03_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_003004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000034">
        <property type="protein sequence ID" value="KAF0741812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XN03"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012479"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0741812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="403" mass="44227" checksum="134A17557D78C491" modified="2020-08-12" version="1">MPQRASMMELDVRVEESPLQSPSPPSLRLKTPSQSVKKPKSPPLRSPTVKILDEKSRLMLQVIQDYGPYSPRREYSCRSLPKPRDQDFILRHNAQNIHDFKSEYSKRFGTLNRRPAMFQAALSPSSSSLRSPSAGRARESLWRESKDTVWILTDHGKQTLLANNSNLSPLPRLPTTLPAIHTNPTRPFQHQAAVGSRVDLSQQTSLASLVRLELYSPRNKPKVEQRPDAACRPSTSDGFSHAASSSPLSSWTPRYRPHSSDDKESSSHLALSPPLPPHSPSPLSITTPSVITIEPSIVNFHVVQIGRTYAFPVQVHNVGAKTDRFRVRSLKVKSGGVDCSRADAHYDKNKAKLAPGLRATVTLFVVFAAAGSIQGILEVETPAGKGGVAIIGAVEAPSSKRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XND0</accession>
    <name>A0A6G0XND0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_003091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000034">
        <property type="protein sequence ID" value="KAF0741905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XND0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011346"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0741905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="108" mass="11396" checksum="81E6010CCF44EBAA" modified="2020-08-12" version="1">MEGLSLATLPWQVVVGIVIANVVIDAIAGDILRDPATGRIKLYIALLSALNAAIAGMVASYLPEEHEDYQMYTLIVMGIFSGPAINYIVEIVSSAIDPAGSKPKPVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XNF6</accession>
    <name>A0A6G0XNF6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tail specific protease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_003113</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000034">
        <property type="protein sequence ID" value="KAF0741927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XNF6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000912"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.44">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11261">
        <property type="entry name" value="INTERPHOTORECEPTOR RETINOID-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11261:SF3">
        <property type="entry name" value="RETINOL-BINDING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00245">
        <property type="entry name" value="TSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Tail specific protease" evidence="2">
        <location>
            <begin position="223"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0741927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="433" mass="48252" checksum="6BB0AA6A4884633F" modified="2020-08-12" version="1">MLRPAERFAEVEEAAARVMDDFVRNVVVLLVPPFQTTRRGWLHACFLYPLQCVEAMLIRPVSQLRRHMPLVGGVCVICLTLWSLCLRSVWRHFYQMLTTLTSTHHARFNFDAFWGAIDRYYVLTDATSCNWSLVHSIYGDKIEASTSQEDLWTAIHDSMALLGDPSVRLLHPTASGVAPAIPDAPSLQARIAALEDLFPNPPLQVVANRLVWGLLNPSIGYLNLSALAGFVELSFPLDYFASPSSPQQVPEMYDLETMRWALHALLHHSRTLGLQGLILDLRWNCGGGSHLSVLTAAACFQPPKTPAFSIEEEMKSWGQVRRRTFTIPSSSERYDGPLVVLQGPETAGTAELLLLALQSRRRTVFVGTPTAGKLSDVMQVQLPNGWVVEMPYQQCIATDGERYQGRGIPPQTLVVNQSDDAVLSMALQCFEHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XPY8</accession>
    <name>A0A6G0XPY8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Myosin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_002592</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000027">
        <property type="protein sequence ID" value="KAF0742497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XPY8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012299"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF706">
        <property type="entry name" value="DILUTE CLASS UNCONVENTIONAL MYOSIN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0518">Myosin</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="10">
        <location>
            <begin position="82"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="9">
        <location>
            <begin position="1154"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="6">
        <location>
            <begin position="633"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="903"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="936"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="176"/>
            <end position="183"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0742497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1211" mass="136403" checksum="370FD941DB004D52" modified="2020-08-12" version="1">MGVEMMPGTLCYVPDEAEAWLPAQVISHNPSKKQVDVKVFVTPQKTETRTVDFGDKKTLALMSGKGQSDASIDTLPVQNETTNVEDMITLNYLHEAAILYNVKTRFLALQPYTYTGDICIAVNPYQWLGSLYSDEQHLKYQRSKKDELPPHVYATSVSAYRSMSNENRNQSVLVSGESGAGKTETTKILMNHLATIAGGLNDATIAKIIMVNPLLESFGNAMTMRNDNSSRFGKFTQLQFDAKGTLVGAQCKTYLLEKTRVITHEGPERNYHIFYQVLASGLSELHLDPNFEYAYLGKLHTTSIEGHTDAQHFEKTKAALERIGLSSTGQTVLFRTLAGILHLGEVEFAAVSDEASQLKPTCNHSHHVCDLLGVDRPALEAALCSRTMQARNEKYNVPLAKADAEQCRDALSKGLYANIFDWLVALINTSLSNATKMVNHIGVLDIFGFEHFKHNSFEQFCINYANEKLQQKFTFDVFKTVQVEYEEEGIQWNHIAYADNADVLQVIESKLGLISLLDEELMRPKGNEEAFVAKAALLMKDDPVIEFPRMSRTQFLIHHYAAPVTYDVVGFLEKHKDSLLPDLAQLMRSSSTPFVAKMFAEAPVASDASLAKRRSTGRSLALQTVGMQFKNNLSELMASIQATNVHYIRCIKPNSIKSSTAFDHSMVIAQLRCAGVIEAIRIARSAYPIRQSQTEFLGTFGMCYPDIMAKKNIKSSTDLCLEIIAQVPQWTSPVHFQVGRSKIYFQLGVIDDLESRKRQYLYDKVVLMQRILLGCTKRRQYQRKRVAIVKIQSVVRCVLAVVRYQTIYRGALALQSRWRGIVARRHYYVLQRQHKAHIVYAFVKGSHERLRFLKMKHSAVAIQSVFRMKFNRAKFARRLADARSQESMQRQLRTLQERLQVEQSKNNYDDATASESFRRRRKSSAQMVMADAGGMIDLIEKDNVRLRRELEELKAAYSLLKDETEKLKQEKEITTAAQHVKVRQQEDHVREKDKTIAALQKEIEKLRASGANGPGSNNGGPAPLLQYASQRSRASFRTISTRKEPRRVDHPDTSEALAGVGEALAVANKSMETKTFLKDSAQKLGASLDVDPTATRMALTNGLVGANSLRASPSVSSLKDRVAQMKNKYSQRDNEEYARPSLSDSVYRGSMAIPPLPPGWQVRMSRSKGRPYFLNEAMRLTLWDPPTEENIARAIAKRDRYADRQKPLTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XQ99</accession>
    <name>A0A6G0XQ99_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Brix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_002568</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000027">
        <property type="protein sequence ID" value="KAF0742471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XQ99"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009372"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045112">
        <property type="entry name" value="PPAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12661">
        <property type="entry name" value="PETER PAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12661:SF5">
        <property type="entry name" value="SUPPRESSOR OF SWI4 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="27"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0742471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="441" mass="49604" checksum="7585E105F519EAAB" modified="2020-08-12" version="1">MPRKGGKRKKTRTHVSSAANNADDKTPKSFVFKMGKAPSCVISLVQDMRQVMLPFTADRLREKKKNTIQDFVHVAAPLGVSHFLAFSHTTAGTNMKLVRLPRGPTLSFKVESYSLMKHIHSVQKRPVDSSLAFKTSPLVVLNNFTGDEDHAKLLNVTFQNMFPAIDVQTIQLSECRRVVLFHYDKETGLVEFRQFVIRAMPLGLSKSVKTLVKSKVPNLGNMEDISEFVFGGANTGMTSDSEVDDESAHVVLPDKFRGRGNQKSEKSAVRLAEVGPRMTLKLTKVERDVCDGDVLYHAYVQKTPEEAAKLKAKKDMANALKRKRREEQEANVAKKNEEKEAKKQAKANKKSDVENKRRQLMQYANTEDVSDLEDAEYYRQEVGEEPDAYMFSDRKTDKKKSKDDKTPAPKKSGAKATFNKFKGGNKGQKTAKGGNDKKRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XRG7</accession>
    <name>A0A6G0XRG7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_002198</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000022">
        <property type="protein sequence ID" value="KAF0743143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XRG7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015841"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051053">
        <property type="entry name" value="ECH/Chromodomain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684:SF12">
        <property type="entry name" value="ENOYL-COA ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0743143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="272" mass="29980" checksum="FC5FC9573E8892A6" modified="2020-08-12" version="1">MASPTPVIPSATHVESWYASKTVGVIKINRPRVKNSINQQTYSELNDALLFFQDDANVLVVVLTGEGDEYFSSGTDVNEAKPGMVASRTVTRTLMTTIVNFPKILIGAINGHAIGIGVTMLVYCDFVFSVPYATFRTPFLELGIVPEFGSSLTFPALFGKVAANDLLLRCKTLDANRALAVGLVTEIVPSLGFRETVLKLTEDITTQLHAKHSLLTFKEQMGRLGPLTKQQIFATIDTEFVEIDRRYRTGEIFELGKAYVAQLKQRKNASKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XRP0</accession>
    <name>A0A6G0XRP0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_002095</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the histone H2B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000022">
        <property type="protein sequence ID" value="KAF0743035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XRP0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000585"/>
    <dbReference type="OrthoDB" id="7686794at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000016">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="12">
        <location>
            <begin position="16"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0743035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="120" mass="13456" checksum="882C3A9E84F36BB5" modified="2020-08-12" version="1">MAKQAPNKKTAKAPKKSGNEKKSRKTRRVESYSTYIYKVLKQVHPETGISKRGMSIMNSFINDIFERIGAEASKLSRYNKKMTLSSREIQTAVRLMLPGELAKHAVSEGTKAVTKYTSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XRY2</accession>
    <name>A0A6G0XRY2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_002168</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000022">
        <property type="protein sequence ID" value="KAF0743111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XRY2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009965"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031251">
        <property type="term" value="C:PAN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06143">
        <property type="entry name" value="PAN2_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000175">
        <property type="entry name" value="RNA exonuclease 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050785">
        <property type="entry name" value="PAN2-PAN3_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048841">
        <property type="entry name" value="PAN2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028881">
        <property type="entry name" value="PAN2_UCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15728">
        <property type="entry name" value="DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15728:SF0">
        <property type="entry name" value="PAN2-PAN3 DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20770">
        <property type="entry name" value="PAN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13423">
        <property type="entry name" value="UCH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="2">
        <location>
            <begin position="837"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="488"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0743111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1042" mass="114951" checksum="3181897194615790" modified="2020-08-12" version="1">MHSSFSQGSQQQHNGYDYFDSSDVYAGGEEWVEWVRVPAPLSADEVACTALAFDQCHQMLWIGYSNGRLTSHLLPTMDKYTSIVSNSTAVKQIVPTYEGVVAISDQMAVFRSRGCVHNNAVLVESPQSITCARLARPDTPKASDHLLVGLTSGNLAAYDLQGHHPLQPIWSMDFYNATTALASSDDSSFACAGTSIGQLDLFDVNLRSRRIEASIPNAHSGSVVSMDMIDNYVLTCGVSSRSINPYDKNAPIKIYPDPLIKLFDLRTLSLVSSIPFPSSLGLPPSFVKFHSIHHAFYATDSEGELYSFDMADPMQYSQVCQLPSSVAAWDVSLTGEIMAAGSATDGSVALFDSGTSAAPHALLEPSELPLDFPPTRPPRPPLTLSPLEPAPASRYVFRPSVNAYGEEITPLSAWLPSIPDKTFKQAMTLVVAPKPTKVLHPDFDKKIQQKDTIGYTSHRGFDARNSFVYGQGRATTLATVDPRFADASTKTRQASASRASSTRSFDEADPTHQVPSSYKYVEIKLSKHGMDGFVFDFSKYNRTTHVGLENALPFAYMNAALQLMYFAPGVRSLVLGHLCEEPHCVACELGFLYHMMDQTKAKAPPKARSCQATNFLSALHQIADVAVFGLFDKTLSILARVERMLAFLTTSLPLATPWHRVKLSYDALTPESTLEAVLELSKPSKADLICVECASVDWLTNSDVKNLWNSRQWLSSKTIHVGGEAFHLIGVVSAVVRNPHKSHIVSGPNAHLVTHVWTSEEWLLCNDFSVTTSTEDDALDFSPQWKFPCVLLFSRGSSDYESTVETSIQIPDSIFQAAPLNPGAAAVEMPRLPQRGDRVAIDTEFVIVEMEEAVLQTDGTRIVTKESRQSLARVSLLHGETDNVIVDDYVLPNEPVVDYLTRFSGLVAGDLDPTQSRHNVVSLKTAYMKLRYLVDAGCVFVGHGLRKDFRIVNIFVPPEQVIDTVELYQQPSMRKIALRFLSAYLLKAEIQLETHDSIEDARAALKLHNKYLELVERGEFDKTLVEIYAAGRLCRWKIADLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XS24</accession>
    <name>A0A6G0XS24_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Intradiol ring-cleavage dioxygenases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_001951</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000019">
        <property type="protein sequence ID" value="KAF0743261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XS24"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019784"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03457">
        <property type="entry name" value="intradiol_dioxygenase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315:SF1">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026191210" description="Intradiol ring-cleavage dioxygenases domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="3">
        <location>
            <begin position="128"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0743261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="378" mass="40663" checksum="5152D2DF0407CFAB" modified="2020-08-12" version="1">MVHLKLTLVTAILAFFPSVDAHPNHQQQHLVNDQDTQAIKQQALRSLKACEHSTQARRLQQRTAERRELQLRQLREVVLNRRRLSADEVAAKSHKSNLTGITSFDTADNTLLFGTSPKCVLEPEVTQGPYYVKGELIRNDVRESQPGIDLFADIQVIDINTCEPVSALYLDFWHCNSTGVYAGVVANGNGDSSDLTNINATFLRGLAPTDEDGIVHFTTKFPGYYTSRATHIHVLGNHGGQVAANNTYIGSTVSNVGQLFFDQDLITQVSATGTYATSKQQLTLNANDGIFREEAATGFDPVMEYVFVGEEIDDGIFAWISVGINASESKYVSPAVLWTAGGGVPASGGGGGPPGGPGNNGTFPPGGPPGNGPPRPRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XSM6</accession>
    <name>A0A6G0XSM6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_001882</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000017">
        <property type="protein sequence ID" value="KAF0743409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XSM6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011693"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14008">
        <property type="entry name" value="STKc_LKB1_CaMKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003032">
        <property type="entry name" value="Ryanodine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF72">
        <property type="entry name" value="SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02026">
        <property type="entry name" value="RyR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="11"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="128"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0743409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="675" mass="75693" checksum="9136CFF4FB61C4B5" modified="2020-08-12" version="1">MPRSSSHRLVDVVHEGSLGFTNKHGKLRTQWFALDGAQHTLTRYATSERSKLRGEAIYLLGARIERLPDLKFLVHLHHPYHGLKQLEYVAATPEDKETWMKALINCVNGVASSMSKRMRHRGVLNGQYILVRELGRGASGVVYLYTYHGKPCAVKKVSSKSTKLAQNDVKREIALLKKATNLPHVVSLYDVIQDHDNDCVYMVMEFLGGGPIATYDKAEKRFTTKQHFVEADIKRLMRCTTIGLKYLHGHNLVHRDIKPDNILLTGDMSECKLADLGVAHWFDSVAASVDDTQSMDALRDTKGTYEFMSPEAISGDAYSGFAADIWALGVTLYALVVGKLPFQADSILALFDLIAQVPVVFPASLSPDLRDLLERMLTKDPKARISLEDVLRHPWLSAGATKTFFKHATCRFTQIELDDTDIHGAVSPLQLKFDMMRRASPVEQVALLSAESVQPTFNAPYNPQPIEINSETELPAALQADASLIAHQVHFQWCFDKCIAGWKHSEERNDDLKLHPLLKPFRELDSAAQARNLSSVATSIKCILALGYTITKTKAPHRPTRPVSIPMSLTRITLSGELIVLGDLLAENDHEVWAREYMQKEWTFGSTYDQAAKHHPALVPYPELPESHRETTRLGALNILKSLVGLHYVIEHPHAKYHETIVPTQRRRLSSSKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XTS9</accession>
    <name>A0A6G0XTS9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_001588</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XTS9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012265"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.270">
        <property type="entry name" value="Methyltransferase, alpha-helical capping domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005299">
        <property type="entry name" value="MeTrfase_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042086">
        <property type="entry name" value="MeTrfase_capping"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31009">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE:CARBOXYL METHYLTRANSFERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03492">
        <property type="entry name" value="Methyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0743948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="39111" checksum="6C47BAD1BC2D76EE" modified="2020-08-12" version="1">MQGNGAYNKAAVCQMSLVDYTTDLLKQAMARFAKHSTSKSSYNIVDLGASQGRNSLELLHHLIKHLDASLPENASPDILVLHEDQPANDFASLLDTLNSPQSYIHTRRNVYTGAISKSFYGQVVPSASVDIVVSYIAAHWLSKTPAPLPGFIVMINDPQAESILSPNVLATWKEAAHEDLVTFLRLRAAELVDNGSLCMTFISDDETPLVYEYSRRLRLGLEDMVNAGVLSSDSLDRAAIPAFMRTKQAFLAAVADVPELELHEHQFVPIPVKFSSGAEAARFLSSVAMPSLEAGMTEEERKDPRMHEMFTTCMANRLSEPLAGASAPFFEQFTIIYFYCHLTRRERIKTRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XV02</accession>
    <name>A0A6G0XV02_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sphingomyelin synthase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_000966</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XV02"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010433"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025749">
        <property type="entry name" value="Sphingomyelin_synth-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14360">
        <property type="entry name" value="PAP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Sphingomyelin synthase-like" evidence="2">
        <location>
            <begin position="188"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0744490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="266" mass="30441" checksum="546ED5282D265305" modified="2020-08-12" version="1">MSPLNYIEKLCLLTDVAAPSKHVKEQRQPRVDPVDLAFVPTKHQEYEQGSMVHAWQTKWNRSLASKVDIIGSVCALVWSLQIYQNFLRWNETRTDIHGFALLHDPVLRQLTPHDFSLPLFFLVYGAVILALVYGRNKPDFVMEFLQAKTCVVWMRMVALFLVPLEVPADTIPLIDPIAGGDGVVLMRDLFFSGHTATTFLAFLTCRRQDWSWKLFFLCMALTTAAMVTLQKTHYAIDVFAAPFFVYTCHGVVYELRSQYNALYMAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XVK6</accession>
    <name>A0A6G0XVK6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_001061</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XVK6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009471"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF98">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="134"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="276"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0744594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="541" mass="60083" checksum="2AD422A74F94D52B" modified="2020-08-12" version="1">MQRTVQQSGKSIVEEDTPFDPWNSRRSNSIKLHSYESPVKQYVEVKIGGHTLDHKHVADPKASVAHAPMKVTPKTISGHNQASVFQVHHKERMQYVEVKIGGHRYDHKRCVATDETLVGFNNQLSVIKSGSIGCALCFGIDVGPLVHLYCRHAVCIPCFDSFTQNGTRVLCQVCFKKVPFLHPHMMLASQQTAKSDASMDFDKMTLAVSCVGLGYAGPKVVTRISHALRGISIGETAVPKLTTTLAHVNEIIDTDGAQSWRNRVQLVMEPSKLLRYEYVDTLGQGNFSQVLLMKKSYSICRIVDHIRRSGGALCVLKESDKLQEAMNEISVLSKLHSPHVVRLNQYFIEQVGHLHYAYLELEYCDRGNMAEYIASQGKMDHDMFARVMLQLCSGLAEIHRHNVVHRDLKPANILLTSDGVVKISDFGVSTCLESALVTRHAAGTMSFMAPEVRRYFLGESVEYDWAADIWSLGAVAVALLTGMAEPKVATRPVDDIVDSLTRQNVPANFVRAVQGALEPEPSARASLEQLQAWIASTYSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XW23</accession>
    <name>A0A6G0XW23_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_001110</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XW23"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015258"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
        <property type="entry name" value="FYVE_like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43102:SF2">
        <property type="entry name" value="GAF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43102">
        <property type="entry name" value="SLR1143 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="5">
        <location>
            <begin position="29"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0744648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="404" mass="45476" checksum="6B8EDAF12F154607" modified="2020-08-12" version="1">MLRPGSASDEGPRSIRLEDILSPARWACKKERLTCGDCRLKFSNLFRRRHHCRLCGELFCKQCVLLRELQVPAQGKQFVKVCKTCFLDDARTANSSSSCESPKRPHSVKSMWGIFSNDIAAISTPTFDYERRSVLDMTTRTPPSVDRNSEKRRLDVLRAYHIDYTAPDDTLQSICMKAARALKCPIAYVAFMEEDTLWIKSSVGFNLHSIPRDQSITAHVVQTREPLIVTDTFIDGRFHDTSLVIDHAIRFYAGVPIANKNGWVLGALVVLDYEQHVEKIDVRQLTTLAEATMDNLRKPRSISRQRTISHDSSKPRASVLLLDADFVVDATDRNSEVGLRLTSSDRSGLSESTLMDLLAQSTNTQRSLAQHNTHLATTLGTHSEKLDQLTQAISRMESKLRDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XWN3</accession>
    <name>A0A6G0XWN3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_000707</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="VJMJ01000005">
        <property type="protein sequence ID" value="KAF0744874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XWN3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012085"/>
    <dbReference type="OrthoDB" id="10252009at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033550">
        <property type="term" value="F:MAP kinase tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017017">
        <property type="term" value="F:MAP kinase tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008330">
        <property type="term" value="F:protein tyrosine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF511">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01908">
        <property type="entry name" value="ADSPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="59"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="7">
        <location>
            <begin position="122"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0744874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="203" mass="22594" checksum="9031D7771627DD02" modified="2020-08-12" version="1">MEEGTDPAWTTQDSPPDANASATPKADLQNIDQKKQAKDSFRKFWHGMLTQKYLEQDNQPAQVLPNLFVGSVGAASNWESLCSLDITHILVAGETLALTFEESGRFEYLRISVSDTPSTRICDHFEKSNAFIDRGVEKGRVLVHCFAGKSRSVSLVIAYLIATNGHTYESALAFLRNVRPHARPNNGFAMQLKAYAKQFGRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XWZ2</accession>
    <name>A0A6G0XWZ2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_000587</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NFYB/HAP3 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000003">
        <property type="protein sequence ID" value="KAF0745006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XWZ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014749"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027113">
        <property type="entry name" value="Transc_fact_NFYB/HAP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064">
        <property type="entry name" value="CCAAT-BINDING TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064:SF9">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="6">
        <location>
            <begin position="408"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="309"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="502"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="524"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="538"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0745006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="570" mass="62352" checksum="B5638C45FAFB1C71" modified="2020-08-12" version="1">MESTNMTVKPVSPIRAKSPASLPIRNNGLQNSAVPKQQEGPSRQVAAAALYRNTNGKNRPNESSAGQLPHNQAAKNANQPLQNGPVLSTSRQGPHALTVHVPTQSQVQNACVSNGGGMVSSNRTGELDETVGAAAKSPSLGTITFNGSFEDECKSMLLKLLFSFHQASTPDEVVHALNSLFAWIKTQTYNPSPTSKPESLPSPPKSLISLPLLRHAKNEFIQCAQIKQRRQPSVWTTAVSQTYATILQHLLLSIQSQTQLQNQAQRLQQQQVQLQKQQHATPGPALQHQLQRELIQQQIQQRMQQNISQAHAQFSRLQQHRQPSSPMKSSPPALQKNATMPIDVKSRQVAKPITASPRPKDCLLSPSGGALPVPSPVLSLALPSQDFYVDMTLRTAKTVPSGDDDQLYLPQRNISKVMRTALPNDSKIKIDDDAKELMQECVTEFILYLVSESRDQSVVHTRNKASLTGQDAIKAMYNLGFTTYGDLLTIYNEKITAVQREVSKSKSEKRMAKKGLMQPPITPQTPSQPQTPVAIQPQPTPQAPIPSPALPLLQPAPPAALVMPHPPETM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XX11</accession>
    <name>A0A6G0XX11_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_000301</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XX11"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001619"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038039">
        <property type="term" value="C:G protein-coupled receptor heterodimeric complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004965">
        <property type="term" value="F:G protein-coupled GABA receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002455">
        <property type="entry name" value="GPCR3_GABA-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519:SF20">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 156-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519">
        <property type="entry name" value="GABA-B RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="640"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="677"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="710"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="752"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="799"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="833"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="10">
        <location>
            <begin position="645"/>
            <end position="882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0745270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="885" mass="98042" checksum="D9DB1B6322A37C19" modified="2020-08-12" version="1">MPLRTGMTCVVPAGSVAEVNEKKLETNYRRRAQNAKPKTAPPKADAHEFSKGVVASRAVMATTYPGPYESTRRKCLDATWVADTAAAYQLDPNARDSQNRLVNPYLRPALKYPRETTTKGKPRIHGIGERIYANGSVASAGEVQGTLTLEMSDRPSHQLATAVMSILLQEVVGYDVTIFDAKDDLNTAERMASTGLGLCTPTHLDVEVWTMGKLTTHMKYSGLVRARSIGYTGIAGIYTLHSNIVTALAGNQTPFTRSYSADFWREYVLSDDLVKFYSIQKTLNLTRIARPEVCPDGILGCKNGCGKNDACTTAEANGRTCVVVAMMNPFYNIGFMESMISNNRIPAYFCYSTYSSVNQYVLDTMKANGTVLFYHFEPDAFQEDYKGLLNRIAFPTTDPEVVWAATNVYGELGYGKATSNPVQVDFPEASLMMYLSDFLATDEPLLYSFITNFQITASRMANLLHNYSAYKKDTSVADPVFAAACNWIRKTSKVWKAWIPHLPLCTLVDHMYYSIAGCDDTMRTLSFTWITPDPDNASLPYQCDGGLYRLPDPIPTSKSCDWINNNYETWQTWLTTLPKCDATHYNYTIGPCDSDANRAVTFYWLLPRPGLNGSIECTGGLSLPHDTSVLCDYLPTSSPAYHSIMTLSCIILAFFAFCFAIVVTFRERPIIKRAQWPLLLFIIVGGMVMCIDIILASGEPTDWLCASQPVFDSLAFSMVFVAITVKSLRVYLLFNNKSLKKVTVTLWQMLKLYFVVVGIDVGIVLVGLVVDFPNPSIVVTASTAFEGSVDRIKCRSSSIIFSSISVFWKCIILCTGLYLAIKIRHADSDFQETMWIVASLAVLVIGGIIMVPVVFLIEMAPPMSFTIRSSTLLIGTVSNLACDQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XXB2</accession>
    <name>A0A6G0XXB2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_000383</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XXB2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011964"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="2">
        <location>
            <begin position="30"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0745361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="463" mass="53556" checksum="3D07DDAC84F00405" modified="2020-08-12" version="1">MLLTDVSPIQNALADTAMMAQSDTKLLSSCQICFDEVDGLNIATEICGSMCRASICSTCLKDYIRVQTESVPMGVLAKLKCPICLRPANLLRWKERCVQATEMIDSFAERVRASCDILCPSCHRPSNVLPSPSEQDPIEPVEMDASLLEQLPALQDMCNQFCQHKVSLDALCQFARERFPGHYAALTHRLVPLIKDTERRRHLLYMQDQGPPPRQTLRIDVGHQRRPRSLSKVQLTLVKGDGCDSVTCFCGSSFSWSRRVTLFRWSLVPRRHVDALSGIFRPFVNFRRLRKRVLPELIFVSKVRKFKDPFKVVCDYLRSKVHRRRVRRLVLPDVKARVVLMLISKHKKPLVVVREHLLLRVWRQRFSTAVLQSKRFTEAIIQRRAKHCVNMVEQQPWIKARMLAATATLFRHLIQRRKRTALDKLMQLLQKDLTWIEMTDDERAVAELEQQDFFTSMFDTGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XXL5</accession>
    <name>A0A6G0XXL5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_000487</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XXL5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018126"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015227">
        <property type="term" value="F:O-acyl-L-carnitine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902603">
        <property type="term" value="P:carnitine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006839">
        <property type="term" value="P:mitochondrial transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF4">
        <property type="entry name" value="CONGESTED-LIKE TRACHEA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="12"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="116"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="208"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0745473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="309" mass="34177" checksum="4DE8A7209B3C0337" modified="2020-08-12" version="1">MLVSPSTMDKVETVLTSFVGGTVAGVTGAIVGYPFDTIKSRIQTQMHLPSSSLSSTATPLQAFVHSIRQEGFLSLYRGASTQVARSAIGCSILFGLMAQFKWLFSSPPLSSQNVHPDTVLVASAACTGMVEASIYCPFEITMIRMQTQATNSQTTWQCATNIYARYGLRQGLYRGFIPTCCREMVGNTVYFLTYERLKDSLKAKTDRTDMEIFGISGAVAGLVYWCVSFPLDTIKSVVQADALEPKERKYRGFGDCAKQLYAEGQAKRFFRGLSPCLIRAMPVNAVQFMSYEKSMEVLMPLWPKRSQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XZ04</accession>
    <name>A0A6G0XZ04_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_000205</name>
        <name evidence="2" type="ORF">Ae201684_000206</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000001">
        <property type="protein sequence ID" value="KAF0745757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VJMJ01000001">
        <property type="protein sequence ID" value="KAF0745758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XZ04"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015349"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0745757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0745758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="188" mass="20804" checksum="CBC62F7364684494" modified="2020-08-12" version="1">MTSLSNEIATCCKTLCAQEAWVFGKKHALKAVEGLFRETTRDSKDAVSVDVLLPLAAPMAEHLLPSGHTDTIKTTCALLVVFVKTLGVAFCPFADQVVVPLLNVGRKMRRRTTEERLANPSLPQSKLVDQMLWESAETCLDVMSSKSRYNLVPMLDHYDECRSVSVQCLVLKQVGIVLGSWTKPELEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W3Q9</accession>
    <name>A0A6G0W3Q9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Terpene cyclase/mutase family member</fullName>
            <ecNumber evidence="4">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_019059</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the terpene cyclase/mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="4"/>
    <dbReference type="EMBL" id="VJMJ01000382">
        <property type="protein sequence ID" value="KAF0721592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W3Q9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004088"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031559">
        <property type="term" value="F:oxidosqualene cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016104">
        <property type="term" value="P:triterpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02892">
        <property type="entry name" value="SQCY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000002">
        <property type="entry name" value="Terpene cyclase/mutase family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032696">
        <property type="entry name" value="SQ_cyclase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032697">
        <property type="entry name" value="SQ_cyclase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018333">
        <property type="entry name" value="Squalene_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01787">
        <property type="entry name" value="squalene_cyclas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764:SF20">
        <property type="entry name" value="LANOSTEROL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764">
        <property type="entry name" value="TERPENE CYCLASE/MUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13243">
        <property type="entry name" value="SQHop_cyclase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13249">
        <property type="entry name" value="SQHop_cyclase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01016">
        <property type="entry name" value="Prenyltransferase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Squalene cyclase N-terminal" evidence="6">
        <location>
            <begin position="154"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Squalene cyclase C-terminal" evidence="5">
        <location>
            <begin position="460"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0721592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="805" mass="91166" checksum="F9969F70FAA9FE04" modified="2020-08-12" version="1">MSGRGSAALDELEWDSSEFMSGIALKFLEVFFDTRVFTTLLVGILLIKLLPTTDPILGMGQIKKPRFAPRSHVYSTDLKVVVGSDTGPDGRTRVRGNVCGRQVWRPQGKVVELPPFSAAENMNAGDKLFRHLVLEGKALPPPRNKEGDVEEALKQAVEFYKLLQSEDGSWHGDYGGPMFLLPGLVITCYITGYNLGKSIKEGMVVYLRNHQQYDGGWGIHIEEGSTMFGTAMNYVALRLLGVPADDKACVEARTFIKHHGGATLIPSWGKFWLAVLNVYDWRGVDSLPPEMWFLPRWFPFHIGKSWVHCRMVYLPMCYLYGRRFQAKETTLIQAIRSEIYTVPYAHVNWSNARGAYCKLDEYHTPSPIIRGINYLLSWYECLPTLTPLRKNAIDYVLEFIHADDLETNYCSIGPVNKVINMLCVWVNDPNCQEYQEHIQRIEDYLWVAEDGVKMQGYIGSQTWDTSFAIQAMIESGLADYAPLQATYKKAYHFLTEAQNLKEAKDAHKWWRHAQKGGWGFGTASNGYPVTDCTAEALKTMLKLEEHTTCSGFPESRFQDAADFILALQNPDGGFPPYERCRGGDWFEYFNPAVVFGAIMIDYSYVECSSASLSALQLFHKRFPNYRADDIRRATARADEFIRSLQYKDGSFFGKWGVCYTYGTMFAIEGMRNAGASDTDEDVQDGVQFLCSKQRPDGGWSESFFACATRRYLEEESSQVVPTAWALLGIMKGIQGPSSALYTTEWAVVKKGIEFLMRKQLPTGDWDQERISGVFNRTCGITYTSYRNVFPIWALGLYKTLSPKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W4T1</accession>
    <name>A0A6G0W4T1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta-lactamase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_018648</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000345">
        <property type="protein sequence ID" value="KAF0722168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W4T1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015697"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050491">
        <property type="entry name" value="AmpC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825:SF9">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825">
        <property type="entry name" value="D-ALANYL-D-ALANINE-CARBOXYPEPTIDASE/ENDOPEPTIDASE AMPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026006728" description="Beta-lactamase-related domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-related" evidence="2">
        <location>
            <begin position="80"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0722168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="572" mass="63131" checksum="6AB16B1DC2F137C6" modified="2020-08-12" version="1">MFRVLIGLVALGSYVSSNMLSSIEDLPLKNGVVWGYDALVIPRDERIATTPSAKSTTHGLSRTPGSSLSIDDKKDVAVAFVKKQMELSGIPGMAVSVVVGNETILSKGFGTQELGNSKRLVSPDTLFQVGALSEILIALALGKLGETHQIEWSDTVKLYLPWFTLQDKYAEEHTTIEDLLLKNTVFGIMDGNIPGRYGVFPTNVLLVQALGHLKTKREFRSGSDGSVHNYAILSQVIEAVTKTTWFEYVKAAVLKPLGMVNTFGSPFDVVNKEKVSSGHFYCNGTIIGPYSIFNSSMVETFPSNYYAAVVTSIDDMTKLSHALLHHGKPLFRSSKTLNDMLVGHNIHSFLAEIAKALGYTEISESTQLNTGIGFDLVANIMENQLYFDKNGGGNSFSSAGGWLPIEQVGVILLGNSQGSLGKVVDMYRVYAMRSYLVQLFKGIPVEKLDREFDDWVEWINQRMPELPCDVHYFNGVPWEIPGVIIPESTKQALVGKYCAMDSFSGNLTIARRGEDLTLQYGVYTRPLIATKQENLLIWALERGAMTSPIFVSNLDQLPRIKLLYSIDFTRCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W609</accession>
    <name>A0A6G0W609_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Piwi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_018813</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000358">
        <property type="protein sequence ID" value="KAF0721910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W609"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016389"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04657">
        <property type="entry name" value="Piwi_ago-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032472">
        <property type="entry name" value="ArgoL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032473">
        <property type="entry name" value="Argonaute_Mid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032474">
        <property type="entry name" value="Argonaute_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045246">
        <property type="entry name" value="Piwi_ago-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16488">
        <property type="entry name" value="ArgoL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16487">
        <property type="entry name" value="ArgoMid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16486">
        <property type="entry name" value="ArgoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01163">
        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="1">
        <location>
            <begin position="213"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="2">
        <location>
            <begin position="495"/>
            <end position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0721910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="827" mass="93134" checksum="5E74662FBD6CF04C" modified="2020-08-12" version="1">MLYPCRPSFGESGKPVVLWVNHFGVTVRADQGDVYHYDAAIADEGKKPGHEPPPKSLCTPVLHALIANLKVEYPDIAVVADGRRNIYTNVRFPFESRLFKVAQTKDDKVKMFDVHVKASDPLAIRMTQINQLFEGTLNYTPYDAIQALDIAMRYSASTRFVSIGRNLFNNFSQQSLGEGGELWFGYHQSLRPTQSHLTLNVDMASSMFIESMPALVYMCEACGFREVPATLNKMQKGVATKVFRGIKVRVTHRGQMKRGYRVNGLTKSSANDTFIEIDGNRISVASYFATNYLPLQYPNLQMLHVGSPTSTNYLPIEVCHTVEGQRFLRKATESQLATMVRVTCTPPEERRQKIEARVQEGHFSDENCLDAFGIELNPTMLTVEGRQLPEPALLYGGSHAETPRDGLWNMKNKSFFQTVELKSFAIVSLCDTRRCPTQSIVKLFRHLLKGMNQVDMKGPATVPPVVVQQNGQTIEQLLSVAIGAATTEFGARPQLVFCINPQPNAQNYGDLKRASDILYGIPSQMMLSRHFVKPSVSYISTLLLKVNTKLGGRNTVCKDALPRISTEPTIIFGADVSHPSPMDTTRPSIAAVVASMDRWGVRHAATMRKQAHRMELIEDMEGMATELLKRFYQATNRKPVNILFYRDGVSEGQFESVLIHEVAALRSACEKLEKDYRPRITYVVVQKRHNTRFFPTDLADADRSANVKAGTVIDSGVCHPTEYDFYLMSHSGIQGTSRPAHYHVLLDEIGFTPDELHNLTFRLCYTFARCTRSVSVVPSVYYSHLVAFRARFFMQYDHDSESTVDESQLDYPLPLVHKNLHNAMYYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W777</accession>
    <name>A0A6G0W777_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_018035</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000319">
        <property type="protein sequence ID" value="KAF0722960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W777"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010201"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017346"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
        <property type="entry name" value="FYVE_like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="entry name" value="tt1808, chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="498"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0722960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="642" mass="71972" checksum="3BAE1B18D6B97389" modified="2020-08-12" version="1">MDAVRGDDSVPSAQGLKRSSATVEEGNPKRSRTDNSATPTDSKQPRIEEKPSWNTMIVPASTAAIPEPSQGELMAIHSINQKIKSLDWKLVEKELEKGMVYLGDASLSDWEAFVTSEDQQLKSKNMEWIDGKIFIVELPSREHARYVGELFATIRDATHTRSDFVMTSLDEYQTNIRRLEPDLCLIPRQVLEQPPYNVQLPPGLDDWGNFHTVKCEVAWSQSWANLDWKANQWAMVDTVVYIICIKLDRHNSSYKVDHVVQHGVQLPEMIPLPIAPPNTVIQLDSRLVLQLPATSPLPPNFPPQLDIDLYAPLTFVGLGYEIPLVAITPVFLDKVRLLNISMPTLENPHYYQSLNWTILKTPLGGVIMKHRDLIYVEHQEEVIINGKRAWLRALTHVDIPGCPSWEDRYGIVRGEFLHTGSVYMETDVPGVLENIAIHHNRPNGKLTGAVCDFLMSKVTNSHYRAIKEAEQVVRAHQLSRLEMIAKHHLPPVPRTAKCDVCLKKLGILNDKDYCRRCAKIVCTKSCSKVWKFLKSGIQVRARVCRMCSNAAKQTKLGDTSYGSFHTQSEGYSFTSSDESVATSEAFSCYTGSSYAPSIVVESPTAISLDETYARVESAANAIQLELSSDTSRPKEAPFGTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W7S8</accession>
    <name>A0A6G0W7S8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_017753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000310">
        <property type="protein sequence ID" value="KAF0723314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W7S8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002862"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="885"/>
            <end position="905"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0723314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="924" mass="103231" checksum="76D7E083EE532866" modified="2020-08-12" version="1">MHRFLLPGLVTVSASVEWISATDQLSTEGSRIELADGAYDIAPSPPPAPTVRPDVYSSCVWAGPGQTRNQYDYAIKVLNTPNETDCSNCFPNFFAPGQPLAYPYPRSSYHYDLENAHVVPLKSDDVITVPNIEFDVTIDTSPDAGEPVSKTFFYDFKNFETYGPTILYNSIPHSVGVYNFNLVANDFDDIDSKVCQTCLSVTDMYRPNGKRGSCAESSYNHFTNSNICALQPQVTDLVKYRQTANNNPCSDARCDLVTLASMSFSGAQSTQDFSTTIVSDALDTWKTCLSQPLTDDEWTLLKTSVFGKSCEPTFFTCTRSCAYNIQLKEFYTPYSCAPTYNVESNRRTCDGDKNESCAFKQSITATPDDLISTFNVHLKSNPTKVPIAKPVNVFPGTSYKDPSDTSRELHFDIQCDSNDLDFGSFCQKKFQVNVTDLFELQATLNNDAAIQTLLKNRATNAKDIVFWRVKNTESGDWIEISSFTGNTKSPLTFPRFQSNLIFDAYTACGPLGSIKWTIYIHRTELIRIDDWWYSMWSCGAGKCNVQHTDFRLCNFHFDPKCDTFLSMINPTDAQNTIPVDEKGNAYNICEYKDNNGKKQTCSNGCWWWYSKCDQTVDCDSCNERVLQEGNRFAYCGPNGTYTLPQSGDSTDLLAANFLQNAPPAAPAPAPVPAPVVEVRIKWQFHGFQCKWQYTNAIETKTYWLDTTKDAANQKEINRDIALKMQNVDVTQVTAKCNFFFKSLNADPNSAPIVRNRTKTVLIQNCDHPRWNVKHPEDGGRYIKDTCNQVAWYTDLTKRQPAPFEACKGAMVFPDKPDCTTNNAVTTIYAEATNALTCCNSPTSCFTCQNLPGRESIGVCSDSKTKGVYYEGVQSSAVLLDLSQPYSTQVMVVVGMMAFAVAVIAVKRTTRSEEDVEDVYSLVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W913</accession>
    <name>A0A6G0W913_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_017451</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="VJMJ01000297">
        <property type="protein sequence ID" value="KAF0723676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W913"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018005"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13975">
        <property type="entry name" value="gag-asp_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="9">
        <location>
            <begin position="581"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="453"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="992"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="453"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="468"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="994"/>
            <end position="1003"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0723676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1012" mass="113773" checksum="08D1296FD70283E5" modified="2020-08-12" version="1">MDSTCDFPDDEYTKEIEDRLYPIPKSDIRKQLDQIRKRYINPSHEELLRTLDLSAADSHLLLAPADIEDESVWTKWFADTLEKCDEARRASRDFKTHPLARISWTQGNPYSVLDMDESHGDDMPTDAVDSDDTFEDDDFSKFELPLYVTGPSGYACANAQTRQSAITHYWTELPLTDHLSDSASAKTIAQFKARQQRCLHRRSARVDPTYCSDLLHGNPPSTRLLSRMSRVCHTRGRSETDPFIQAYVENFKATTLIDTGASCSFISAALWQKLGCPSLSQPKFAFVSADNSNLEMLGRIKLSIKLVGRTVQFPFWVMSTALTDCIVGIDLLRYLGAVINLNDNTLSIDGCDELISLTRLDPASSMNHLGGNVTVVAQTIIQPRSFQWVSCHTHKSLPISTSVLVEPHRSQSALLHVASALYRTTSSRTVMVEVANPSDSPIYLDQHTSLGTWMSVPDESSTSTTPPDDAKQDAPTDEPGRVLTQMGGPGVVCPVQSQANTTKEIPIDWTDSSLSTDQRELLRKTLMKFADIFVDSSKAPGRTHLVEFSIDTGDSPPIRSVPYRTSKAEGDIMEAELNQYLDLGLIRPSKSPWSSPVLMIRKPDGSIRFCIDYRKLNSVTVKDSYPMPRIDDLLDVLGRAKLFSTMDIASGYWNVPMAKDSIEKTAFTCKYGLYEWLVMPFGLCNAVPCFERLMENILIDYKWRTCLVYLDDCIVYSEDFGSHLVRLSQVLTKFREAGFKLKMSKCKWGRSSVPFLGHIVTPAGILPNPEKIKSVLRIKTLKDASEVRAFLGLAGYFRRFVRDFSKIAAPLTLLLTEEKFTWTPACDESLEKLKRNLVSPPILAHPDFDLPFAIWVDTSHNAVGAVLMQKQNGKNRVIAYASQSLSKAQQKWISKEMGISEIECWGVVLATRKFRPYIDRRHFDIYTDHEALTWLFNTVSRSGNHKLARWAMEIQGLDYTVIHKPGELNGAADGLSRLAVCPIQTRSMRRLNSTTTGLTTPPTMNVRNDKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W959</accession>
    <name>A0A6G0W959_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_017936</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="VJMJ01000317">
        <property type="protein sequence ID" value="KAF0723065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019209"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021341"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021670"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054465">
        <property type="entry name" value="Integrase_p58-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13975">
        <property type="entry name" value="gag-asp_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22938">
        <property type="entry name" value="Integrase_p58_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="9">
        <location>
            <begin position="581"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="10">
        <location>
            <begin position="1190"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="453"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="993"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="453"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="468"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="994"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1011"/>
            <end position="1021"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0723065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1656" mass="187919" checksum="0A027E1EB579425F" modified="2020-08-12" version="1">MDSTCDFPDDEYTKEIEDRLYPIPKSDIRKQLDQIRKRYINPSHEELLRTLDLSAADSHLLLAPADIEDESVWTKWFADTLEKCDEARRASRDFKTHPLARISWTQGNPYSVLDMDESHGDDMPTDAVDSDDTFEDDDFSKFELPLYVTGPSGYACANAQTRQSAITHYWTELPLTDHLSDSASAKTIAQFKARQQRCLHRRSARVDPTYCSDLLHGNPPSTRLLSRMSRVCHTRGRSETDPFIQAYVENFKATTLIDTGASCSFISAALWQKLGCPSLSQPKFAFVSADNSNLEMLGRIKLSIKLVGRTVQFPFWVMSTALTDCIVGIDLLRYLGAVINLNDNTLSIDGCDELISLTRLDPASSMNHLGGNVTVVAQTIIQPRSFQWVSCHTHKSLPISTSVLVEPHRSQSALLHVASALYRTTSSRTVMVEVANPSDSPIYLDQHTSLGTWMSVPDESSTSTTPPDDAKQDAPTDEPGRVLTQMGGPGVVCPVQSQANTTKEIPIDWTDSSLSTDQRELLRKTLMKFADIFVDSSKAPGRTHLVEFSIDTGDSPPIRSVPYRTSKAEGDIMEAELNQYLDLGLIRPSKSPWSSPVLMIRKPDGSIRFCIDYRKLNSVTVKDSYPMPRIDDLLDVLGRAKLFSTMDIASGYWNVPMAKDSIEKTAFTCKYGLYEWLVMPFGLCNAVPCFERLMEHILIDYKWRTCLVYLDDCIVYSEDFGSHLVRLSQVLTKFREAGFKLKMSKCKWGRSSVPFLGHIVTPAGILPNPEKIKSVLRIKTLKDASEVRAFLGLAGYFRRFVRDFSKIAAPLTLLLTEEKFTWTPACNESLEKLKRSLVSPPILAHPDFDLPFAIWVDASHIAVGAVLMQKQNGKNRVIAYASQSLSKAQQKWISKEMGISEIECWGVVWATRKFRPYIDRRHFDIYTDHEALTWLFNTGSRSGNHKLARWAMEIQGLDYTVIHKPGELNGAADGLSRLAVCPIQTRSMRRLNSTTTGLTTPPTMNVRNDDESPGLDQDNENDNQLNRKPPVQGTPIELFDRRGRPTPRLYNEQANDPWIVALRAFLEEGAIPLDPHLQNLVVRNSHQYVMQRGIVCRYVTIKTPLRNPELVVVPVIPHTLVEEVLYASHASSLAGHLGLMKTRERIRRTAYWLNWQSDCKEYVSKCPDCNRAKGGRPWKQGPMQRMPIYSLRGPFGLVVVDALGPLPTTNRGHKYILVFADYFTRWVEAFPVPDLKTSTFARVFIDEVLCRFGIPDKLLTDRGSNFVSELATTMYTTLGIHKLASAPYHPQGQGLVERFNHTIVQMLKIFVNDHQTDWDTYLPRLLFAYRTAHHETLGDSPYFCLFGRDPTLPLDLAFLNSDPAWKSDDLPQYKRRLASSWKQTRKLVEEQLIQGQNKSAIAKSEQRPVSFDEQSAVWVYKYFSKSSDPDDHRTPKLATHWHGPYRVERKMGPNTYKIAIPTHPDNVVTVNVDRLEPFRGYYSRPYNEETPEDESPLEELTVDFLPRSSFIDRVDFGDGDVAYTSVDSPIHKIVDKRRLPNSREPDYLVQHVDGYQYLMKASNSQTIGLTLMYLKMNNESRKDYLRYEGPDAFLRWMLNLSHQPSITKSSTYTAYSCGYKATYPPDLPYTPLETSYILHEILYNGYTVPQQPVTTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W9B4</accession>
    <name>A0A6G0W9B4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_017286</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000292">
        <property type="protein sequence ID" value="KAF0723906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W9B4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016069"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028011">
        <property type="entry name" value="DUF4476"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052394">
        <property type="entry name" value="LRR-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14771">
        <property type="entry name" value="DUF4476"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="585"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="646"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="682"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0723906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1178" mass="132019" checksum="3554903CBFFC6C21" modified="2020-08-12" version="1">MKWRGRVSWEPDILESVSPANSPSKWHPSPLRNVHNMSTSNGEKSMLRNDSKSQHASPEPSQDEIDALLTKFKIAAEARTGIRDTLLAQYTATPNSYTFVPSPSTEPATDMYERPLSPSVPERKFKNVQRALEGGSSDEEDDDTEAQEMKELYFGLTARGKFFEKYAGLHAKPHCFMPATSKSSAQFKNIQDLNGSEVRMSPRTRFLSACLSDAGEPPLPLLIRKHGTTTFDFSHQSLGDTFIMEFARALRDVPYVEAINVCDNRLSDRALNELLIALETKPNLTRLDISRNEIGARSAKTLKAYIGSSGCTLQHLSVCKADIDDIECAAFMVAFEANKSVVELRMSRNRIGEAENLNVVQPNFTTGGEALGNMLNVNLTLTTLDVSWNLLRLASGITLANSLKLNYNLYELTLAYNALGDAGAMAFGQALVINKTLRVLDLSFNNISTKGASVLASTVLRSHSLTTLTLDGNNIGHQGGKVLMYSMVNNRSPSGCTVSMKGCNLNERNRGQSLFDPLEPGGDYMLDCSDPYDNMVASELLRLATFRKGCAFGRIELKPTRDAPKKSAQPIKLVRREPTRKKSSGTKTLMDLSFHDMDVNKTGSITLTDLHHVLLELGFHPSLAQTEVLFKKIDADNSGTIDEAELSGDLFHAVFQLIDANGSGTIDMEELRQAFVLMGAKATERDVEAAMCAYDVDGSGTIEEDEFVELMRNQVIQRVDQHQAANSAEALALRDESTGAIWTIPSSGFLDIGFIYERELMNERESFACYGLSDRGLKKIVQSVERGKETMQQQDLLNAAVMDTEIRMTAAQAMTLMESCGDMQEQKRVGAVARLLPQLTASKEAQALVKRVLTLRERYMLRLRLGPIYFPLLGIPTNHYVLDLSRPQERLALVKLAEIAQAEKQFSKARSGRGDTSQHGNWENFRNEMVDGKPAILTSSFFQTMPLKGKLEFDYVSTTRPPRGTKPMSDRRFQQLLSQIGRDDLNLIANDSPPRNVHERWNLIRETVRGRKIKQWILDMKKAFHVTNHSKEHIGVKLFQIETAVCDRWITVAQAGEIVRCMPTQNHGKTETCRILFPRIIDIENFMQIFDTLTFPEKAECAYFLGWLNILNPQFPDRYYEFDLSVREEREAVKIFVRLATTEPGENWIHETFGWVRGEPPIPGWELPKSWANVRMLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WBH5</accession>
    <name>A0A6G0WBH5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_016819</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000269">
        <property type="protein sequence ID" value="KAF0724525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WBH5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020045"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0724525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="227" mass="25062" checksum="108A8A9FFEA37F9C" modified="2020-08-12" version="1">MSSVGLGTFVPTHYNAEVWAASKLQVLNVYENESIGSNNGYYGQAGWFTLTSNVNEALLGPNSTRGIFQRSYSADFWHDYVRSNDLVNYYSVDKINISAFISIDYCADGIMGCENGCSKSYACTVADNQGQSCMMVLMMDPDYDPGFLQAAIANNDIPAYVCFGGGDEAENIVVSTMETNEPITFYHNEPDLFHMKYEGKITRIALPRTDGVVSAHSGELEVRPNNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WBX2</accession>
    <name>A0A6G0WBX2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CBM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_017391</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000295">
        <property type="protein sequence ID" value="KAF0723817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WBX2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018250"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026131708" description="CBM1 domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="4">
        <location>
            <begin position="174"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="116"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0723817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="216" mass="22246" checksum="C745B7D5FBD58CFF" modified="2020-08-12" version="1">MFMRWDRAVVLGCVAAMALSSHVHVRDHSKAFDASCTQVSVVGDATYCIAGAICGGKMGACPKKGDVAAADCHSTLKSYVPGANGDECIAPVDAECKPIPSGVLGCVFPANTPRQTASSATPLPTTSAPTTTPASTSLPTTAPATTSKKTAEPTTTPTKPHSIVPSTTNATNSTCSADWSQCGGQSREKAFPNCCASKSFACRAFNVYYSQCLPKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WCQ5</accession>
    <name>A0A6G0WCQ5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tyrosinase copper-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_017183</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000285">
        <property type="protein sequence ID" value="KAF0724075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WCQ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020880"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF126">
        <property type="entry name" value="TYROSINASE-LIKE PROTEIN TYR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="4">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="341"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="345"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0724075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="371" mass="41578" checksum="7952B235A966DEA6" modified="2020-08-12" version="1">MTIAQEYTFQHKCIQADPVGHFCENPRDSRACTRCVPRGAWRSTTFNPDLGIANIKAQIFKSNNIADVTSNLENSPHNTMHGTLDGAMANIFVSPADPVFYSHHATIDALHAIYYKCRVKGLGLSNQERQTNQLSFQGCRTPVGRVTAKSQLTMNVVINGKAIPDDDEPSVKAFFKDIPSEYYALTDTTQLGESSYAYELTELLGDLYAKCEKSGTATQVDQEDEAQRNDGQLSNIVVPVSTKGPSQRFLAWRREIQAAGEALNMTDNQIDDQVVRIRTLFYKNCLGGVTDFSQVFKTMWNVRKSWAKTILDKLRSRKAAIRIKSFPELNEKYFGCRGDELKTSSKSRRARKHAKAKAKTKAKKSKARKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WD08</accession>
    <name>A0A6G0WD08_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase C39 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_017048</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000276">
        <property type="protein sequence ID" value="KAF0724235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WD08"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001302"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018616">
        <property type="entry name" value="GUCD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31400">
        <property type="entry name" value="GUANYLYL CYCLASE DOMAIN CONTAINING PROTEIN 1 GUCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31400:SF1">
        <property type="entry name" value="PROTEIN GUCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09778">
        <property type="entry name" value="Guanylate_cyc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0724235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="24575" checksum="C806203305BE0FF6" modified="2020-08-12" version="1">MEHVRQLADWDCGLACVEMVMRWIYRHLQEPLPRDIRKRIQSVIQSESIWTVDLATYLVDEFDTTSSVDVWFASNVMHVNPVHQAHPFYHAEFAADVARVGPKYTAWQARGAVPRHVPCSELMQRMKDRPSALIVLVDASRLTCCVWGQRARQTGFQGHFIVVVDIVQEDGNVVVHYVDSASDQHTRCRMDGHTFDVARCSPDTDEDLILVSVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WDT9</accession>
    <name>A0A6G0WDT9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_016583</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000261">
        <property type="protein sequence ID" value="KAF0724834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WDT9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016409"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0724834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="126" mass="14331" checksum="1FC8B8D2D74BCDDB" modified="2020-08-12" version="1">MSATHPKAVKPRPRPNIAQKLEIVEQVKEYGLSAVVANYGYSQSAVDKWFSEETKLNDFPGSKTRRRNVGNSGAKAIIPDAHELAIFVLDLRRQELAVTSGHMIKFLRINHKEWLEDYMTTRTSAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WF87</accession>
    <name>A0A6G0WF87_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_016434</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000253">
        <property type="protein sequence ID" value="KAF0725036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WF87"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000021"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF105">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="2">
        <location>
            <begin position="287"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0725036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="675" mass="76265" checksum="158A26C9FC9F47BB" modified="2020-08-12" version="1">MMELEDTTTKALDIDEEDDTSQEFSFHVGEQAYTSTRKELEARKFSSHEEYVEFIGTTFPQAALRSMSRRMRSSPVWKYVYKLDIPQLTKRKKMCEYVCIACLEERVPWEDCLLALFGNRPSNGMTHLLSKHKGLIDECKSPEASSPSTPVVKRKTPTKTTTNKKPKTVINDVISVHHNVKNCPALDETELLKTLVYPMEVEDFMATHYQKKALVVHPSTGVKRYEQLISSGMEDLNVEELMTSTSSEELQAWVRTRDSDGGKIESVKVESVKEASVLYAAGHSLYFQSSPELSGTLIPALANDLGMGFTSTSIQGDVQGEIEIFCARAGHITNWHFDFMENFTVQLQGSKTWKLKKSSITYPVRGCTPHYKTQEVVEQQLKIHRLVDPAFEYNPGDPDEYEEITLTPGSMLYFPAGMWHRVECTEDSITMNLSMFPTPHADIVVDALRHLLLQSDKWRRGVCYYSPEEAQTNMAELLVDLKNQIDSLTAADIIPERLLIHGRSTGDESDDDEEHEEEEEDGEDESEGKAAHSHVLDLSNPEVLSDSSIEFDVDTLVRFNPLANVMHHTNIPAIHQSTGFEPDDEVFILNVGFGHSSYASALRLEFKVNPLQAAIVRAILARRVEKNHDPFSLKSLVESTPSIKNKTKKSDQREIQVALHFLCHAGFLTVVDRQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WGH1</accession>
    <name>A0A6G0WGH1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_015494</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000222">
        <property type="protein sequence ID" value="KAF0726218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WGH1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008219"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440:SF0">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0726218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="216" mass="23828" checksum="58DE9A2CB8A6CC8C" modified="2020-08-12" version="1">MDECERATVKAAQMKLIQSLPYSYSRASPKDVDGVSNYYLTVQKPGSKNALRLYFADTGAWGTFTANQSTYFKSIAKKFRGDNAPAIMFFHIPTVHYANFTGGNGTQGTQGESVTSGIDNAALFDTMVAMGDVKASFVGHDHYNDFCFLEKPIHLCYGGGGGYGAAYGSPKHSRRARVIEWSLTAKKETIETYICRQTEANDFAKYTIYDQSFSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WHQ1</accession>
    <name>A0A6G0WHQ1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_015108</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000210">
        <property type="protein sequence ID" value="KAF0726709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WHQ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012029"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="41"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="186"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0726709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="227" mass="26704" checksum="EC807D53C3CEBE2E" modified="2020-08-12" version="1">MQRPEVSEDIDIFEHSLGLRVRGFKKACTKKDAAMKLDEKRSAFNTTLNTPSDFVPSKPVVDNNRKKTRPQSASSTRRPQFASCARKYETTRPEELPIDFVYDLETRKKLRAAIDSERHELLELNQEREQDLRDADLWLVDKRRPRKEKVCWSTPRRNVPTPTRRDCSLEKTSPLHQALDEIVWARPKKQRPKSAVNRRNSVAENVHFSEWQTSPYHTEAPSRRRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WHW9</accession>
    <name>A0A6G0WHW9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_015044</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000207">
        <property type="protein sequence ID" value="KAF0726788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WHW9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003308"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076:SF97">
        <property type="entry name" value="ATP-DEPENDENT ZINC METALLOPROTEASE YME1L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076">
        <property type="entry name" value="METALLOPROTEASE M41 FTSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="206"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0726788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="429" mass="46832" checksum="234431E3F1044D56" modified="2020-08-12" version="1">MANLVDGLRALWESGVRRVNWKTYALLCILASVGFFRRMAVGRPRPTLLFSTFLKHVAENNVAQVQLAAEFFQVSLKQALQNGVISYRILVPPQTDQTYILDILRQSNVEFGTMQPSVVKRSLPVLLTAVPIIYLALTYRMLQGMVGGGNDGVAKDGHTRGKLKTPNQTRISFADIAGIDAAKQELEEIVDFLKRPQRYEAIGAKIPKGVLLCGPSGTGKTMLARAVAAEAGVPFLFCSASDFVEMLVGRGASRVRDLFTQASQHAKCIIFIDEIDALAKARGGLNSNDEREQTLNQLLTEMDGFEGHTEGVLVIAATNRPHVLDPALLRPGRFDRHVFVGLPDATGREAILRVHVKRIRLHSRVSIKELAVNRQLEGASGAQLACLVNEAALMAVRTGDTSVQMDHFLMAMARSGDSQQATTAYGSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WI73</accession>
    <name>A0A6G0WI73_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_014902</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000204">
        <property type="protein sequence ID" value="KAF0726908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WI73"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021075"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000068">
        <property type="entry name" value="Chaperone protein dnaJ 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000041">
        <property type="entry name" value="Chaperone protein DNAj, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000003">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="27"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="8">
        <location>
            <begin position="139"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="5">
        <location>
            <begin position="139"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="382"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0726908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="413" mass="45037" checksum="305BD0FABB9753F0" modified="2020-08-12" version="1">MFGGGFESFFGGDPRGGGPSGPVDNDAYYETLGVPKTASAADIKKAYRKLALKNHPDKGGDPELFKNFTVAYEVLSDPDKRELYDKYGEEGLQQGGGGGHPGADIFSQMFGGGMRNRGPARGEDLTHPLKVSLEDLYNGKTVKLAVNRDVLCGGCNGRGGPEGAETTCNTCNGRGMRIQMRQIAPGMVQQVQSVCSDCRGQGKTIRESDKCKVCKGNKVTKERKVLEVHIEKGMRNGQRITFKGEADQAPGLIAGDIVFVVQEKEHSVFQRKGGNLIMEKKITLVEALCGFETIVEHLDGRHLHIKSIAGEVIKPNQFKAVHGEGMPQHGNPFVKGQLVILFKVEFPQTVTPDQSRLLKSLFPGPKPLQRLTDAEEAYLSDFDAEAAKQQAQQEAYDSDDDRGQPRGVQCQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WIJ1</accession>
    <name>A0A6G0WIJ1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_014884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000203">
        <property type="protein sequence ID" value="KAF0727019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WIJ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003587"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0727019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="103" mass="12293" checksum="A433F2D5DF94BF34" modified="2020-08-12" version="1">METQIFTPVPLDDGKIDRPTYYERNRDQVRENQRMYRESNREKIRAIHKAYYLKNRAKITAYKRERWHQKKTASKDNNHDGALQPKSPPLPRSLAKLLNPADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJ07</accession>
    <name>A0A6G0WJ07_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA N(3)-methylcytidine methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_014741</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent methyltransferase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the methyltransferase superfamily. METL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="VJMJ01000200">
        <property type="protein sequence ID" value="KAF0727212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJ07"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000126"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026113">
        <property type="entry name" value="METTL2/6/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809:SF5">
        <property type="entry name" value="TRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE METTL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037755">
        <property type="entry name" value="Mettl2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 12" evidence="5">
        <location>
            <begin position="80"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR037755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0727212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="267" mass="30372" checksum="7C58AE109FC4BBAD" modified="2020-08-12" version="1">MKPASSFHAHDFDWNDLAAKCRAQLEEKDQMVVNVSEDELGTLAQSNWDIFHTKNNGKVYKPRNYLSKEFPELRSSNTVLEVGCGYGSAIFPLLAECPSMFAHVCDFSPHAIDILKANPLYDATRCNAYVCDLVLDDTVGVPENSVDVVLMVFVLSAIPPTSFSHVIEKIYRALKPGGLVCFRDYGLYDLAMMRSTKKVSSTADAYDSLYYRSGDNTLAYYFSTEDLAKLFERFDIIDNSYCTVRLRNRRTQTDMDRVWIHGKFVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJ41</accession>
    <name>A0A6G0WJ41_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YncI copper-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_014748</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000200">
        <property type="protein sequence ID" value="KAF0727220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJ41"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000133"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2230">
        <property type="entry name" value="Uncharacterised protein YcnI-like PF07987, DUF1775"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012533">
        <property type="entry name" value="YcnI-copper_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038507">
        <property type="entry name" value="YcnI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07987">
        <property type="entry name" value="DUF1775"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026218909" description="YncI copper-binding domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="YncI copper-binding" evidence="2">
        <location>
            <begin position="21"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0727220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="165" mass="17567" checksum="7DC62A5C4631ED69" modified="2020-08-12" version="1">MQISSVVASAVAFLATLTSAHVEFVTPTAPSNSYSVNTIRIPHSYAGAKTINVTVDLPDGIVSVKPQQVYEWKVDFAYKNVQGTNVVSQVTWYGGNLPNELYQDFGIELQLSDLAVGKILYFPVTQITVPNGTLAWNSTPDAAGKLADAAHPAPKLTVVAASSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJ93</accession>
    <name>A0A6G0WJ93_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SUI1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_014571</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SUI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000198">
        <property type="protein sequence ID" value="KAF0727310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJ93"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010198"/>
    <dbReference type="OrthoDB" id="10248435at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11566">
        <property type="entry name" value="eIF1_SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005874">
        <property type="entry name" value="SUI1_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10388">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004499">
        <property type="entry name" value="SUI1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUI1" evidence="3">
        <location>
            <begin position="27"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0727310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="109" mass="12011" checksum="202B487E596627CC" modified="2020-08-12" version="1">MATIPNFQNFNAFEDAADNSGIGGGKVHVRVQQRNGRKCISTVQGLADDLDIKRILKAFKKNFSCNGAIVKDDELGEIIQLSGDQRTNVKSFLVDQEICTEAQIQLHGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WL16</accession>
    <name>A0A6G0WL16_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_014094</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000184">
        <property type="protein sequence ID" value="KAF0727987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WL16"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009691"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24188">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24188:SF29">
        <property type="entry name" value="GH09064P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="14"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="47"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="80"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="113"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="146"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="179"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="213"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="246"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="279"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0727987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="350" mass="37730" checksum="B1105C1ECA7FF441" modified="2020-08-12" version="1">MHNTLKQVFGFGNPNEEQLVVAAKRGDLKRVRGLVARGANVNFKDKDDATPLIYASKYGHLSIVKELLAHGADVMLADKTNCTPLHIASYKGHLIIVQVLLAHGASVDATDENGKTPLNWASSWGHIAIVKELLAHGAPINSADKQGNTPLHCASTNRHLDIVNELQAQGAAIEAANANGYTPLRHAAFCGYLDVFKKLITCGADIHAKNKKDADTPLHVATWNGHFHIVEELMTHGITLDAPNEFGNTPLHRASRNGQAEMVERLLAHGAKVDVANTHGSTPLHHAACKGHVDVVKVLLVHGAPIDARNSNGDTALHWASMKGKVYFDQELDTTATNKSRKSTMSSCNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WL18</accession>
    <name>A0A6G0WL18_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase C51 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_014080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000184">
        <property type="protein sequence ID" value="KAF0727971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WL18"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000484"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.10">
        <property type="entry name" value="endopeptidase domain like (from Nostoc punctiforme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007921">
        <property type="entry name" value="CHAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051705">
        <property type="entry name" value="Gsp_Synthetase/Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30094">
        <property type="entry name" value="BIFUNCTIONAL GLUTATHIONYLSPERMIDINE SYNTHETASE/AMIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30094:SF0">
        <property type="entry name" value="BIFUNCTIONAL GLUTATHIONYLSPERMIDINE SYNTHETASE_AMIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05257">
        <property type="entry name" value="CHAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50911">
        <property type="entry name" value="CHAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026295308" description="Peptidase C51 domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C51" evidence="3">
        <location>
            <begin position="44"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0727971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="257" mass="28803" checksum="1AA3BCD61FCB1034" modified="2020-08-12" version="1">MQRITTALLLALSVALCVVASSWTPFGTLLGVTDGNVEVFSCHLEPEEEALDQDANYVDDIYTGVEWQCVELARRYLLVNKRVVFGNVDYAFQIFNLTSVRDVDHDGVHYALNAYANGGAVRPEVGSLLIWSPYGEMEITGHVAVVVAVTDTHVDIVEQNVEDSIWPEGQKYSRRLQVKQNATSFFIDKWYEKEVLIGWVTADLKTQVDAPSVQLATEVESVGDVALVGFLASIGIFFVAFRHFKDRRPRHDYDLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WL62</accession>
    <name>A0A6G0WL62_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_014109</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000184">
        <property type="protein sequence ID" value="KAF0728003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WL62"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005594"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169:SF2">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0728003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="25728" checksum="65A8F06C55F81813" modified="2020-08-12" version="1">MMFLTAVARPRYDYTLRKLWNGKIGMWPFVSVVPAQRKSKNRERGTPVTTPITVTKKVYRQYLLEHVIPTIKKVWPGRRSQAIYIQQDNARPHDEVDGPAVLMAGSSEGWTIQLASQPAMSPDFNVLDLGFFNSIQALQHREVVTGIDDLVAAVHRAFDDLDWRVLDKTLSTLQGVMGESLKMGGDNVFKLPHLQKDKKARLGPVPPVVCDPDVVKVIEAMNPGRTSNVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WLE1</accession>
    <name>A0A6G0WLE1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CKK domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_013966</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000181">
        <property type="protein sequence ID" value="KAF0728140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WLE1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018804"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.360">
        <property type="entry name" value="CKK domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032940">
        <property type="entry name" value="CAMSAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014797">
        <property type="entry name" value="CKK_CAMSAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038209">
        <property type="entry name" value="CKK_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21595">
        <property type="entry name" value="PATRONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21595:SF0">
        <property type="entry name" value="PATRONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08683">
        <property type="entry name" value="CAMSAP_CKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01051">
        <property type="entry name" value="CAMSAP_CKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="PRC-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51508">
        <property type="entry name" value="CKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CKK" evidence="2">
        <location>
            <begin position="26"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0728140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="161" mass="18179" checksum="AAB3A373405A949A" modified="2020-08-12" version="1">MELREKKLRQLQERKDKPKAESGAAGTTKKGELKPLSNRQLIHNAIETNLLAGTACEPERIRVLQALFDHPGDNFLVTFKGSVQDMKMTFKGLYALDKDSVYKVYGQGPADLDVTMVKQFFRYNSGKKAFVPVSTRSFTIKTDGAALNDDCFKRKKVQDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WLW1</accession>
    <name>A0A6G0WLW1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elicitin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_013855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000179">
        <property type="protein sequence ID" value="KAF0728304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WLW1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020136"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026079751" description="Elicitin-like protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0728304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="15369" checksum="D282AA72C48734CE" modified="2020-08-12" version="1">MKSIVYLIALALPLVFAAECTDSDFLPLATSILACATASGTTFNASTFNATSAAALCQYADCKTLYTSIGALTCTESGESLAAAAALCSLTTTTAPSSGNSSTPTTTATASGSSSGSTPTTTASSGSSSGTTTTTVAPTSAAGVALLSGAVAMTVATAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WM06</accession>
    <name>A0A6G0WM06_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Myosin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_013868</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000179">
        <property type="protein sequence ID" value="KAF0728317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003380"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF845">
        <property type="entry name" value="MYOSIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0518">Myosin</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="9">
        <location>
            <begin position="58"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="569"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="6">
        <location>
            <begin position="689"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="932"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1003"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1034"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1122"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="581"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="932"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="942"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="156"/>
            <end position="163"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0728317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1350" mass="151069" checksum="7D1F3EED58EC1732" modified="2020-08-12" version="1">METGARVWIHDTEEIWQAGIIEECNESDTNVRVRVEDGSIVSSLAGNVYLRNDHDDFTDVPNLISLQYLHEPELLHAVCNRYEHDLIYTYVGEILLALNPFQRLNIYSSNHVQQYAAAADASEIDMSLPPHVFAIAANAYKSLCEDKKDQSILVSGESGAGKTENTKFLMQYLTQVGALDAETAAAAASPPKPNKRSKSKATASTAQIQTQILQTNPILEAFGNARTVRNDNSSRFGKFIELQFGSHHKIVGAKLSVYLLEKIRVSHQSQDERNFHIFYELCAGADDDLATELSLSDAEDFDLLYESGCFTRRDGVDDADQFQLTSQAFTDMGIPEDEQRSIYGIVAALLHLGNVSFCAKMCQATNMDQACVEDEKPLDLAASLLGVSSAELTRALMTRHVATTKDKIEVKLTAAQASEAKQSLTQSLYGGLFKWIVNRLSMIIRHDSASVNTVGILDIFGFENLTTNGFEQLCINYANERLQAQFNELVFAKEQRMYESEGIEWKYIEYPDNAPCLQLLEDRPHGMWCLLDEEGMLPKGSNEGWISKLYSVFLDDDSVSSLDFKQTRLRRQSEPVPKTHTPPQLTTQSSKPFRPFYATNGQRVEFQFVIGHFAGRVMYENDSFLQKNQDALPPEAIDLCGSSSNPIVQALLQAAPVNNKAKKASAKPLVRQPSNLRSSSVSAQFKSQLDDLIQVIGRTQARYIRCIKSNEKGQPRLLNKPRVVQQLRSGGVLEAVRIARAGYAVRVDHLSFMDAFGFFNHRKSSVKKDTKGQCEQTVAAVMLQFYAHDATIVAIATQVLKAPKYDRVAFQEACGHAGFQIGNSKIFFRKDVYNDMRRFRRQTLARHATTIHRHLRGFVARVIFARKKAAVTALQAWMRACLAYRAMRRRAATTIQAWGRRLVAQIKLQKARRATQQLQRWLRDRSWKRKLSKKVALRKPKLPPTPPPSPPASLLPVKSKSSPEKRQVQPVQVVVVAEPVAEPVVAPPPSPPPTVVTPVVQLGKAPKSSTPPPSAHTSTPPVDPAALRQVDSLVVSLSVENAQLKQRLEALQKEKKLASEAPALPETNPSLEFAHHQLRTLSTQLAQLQMQCAMLEDVDQEATSVDLDIPQPTSLVEAQKQLHSLLHKVKLAKQHLEELEVQQLHLAKARAEEAQALALLEAITPVVTTVRNVASYVPVVSYVVARVEAKTHVTPQTWCMLLQTSQSVVKSMASMASQMLTRKSPAALPPPVDEMERSPMVVKLKQKVDALMELHVDQAIEIKELKAQLQESTIRHQSMQMKFLEDKLTHLMHDMRTHDDDKMKRMEEELAYTTACVNQLANAIVRGPLKDKHHLDSFDLHEPIVYHHPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WM93</accession>
    <name>A0A6G0WM93_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_013822</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000178">
        <property type="protein sequence ID" value="KAF0728460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WM93"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011919"/>
    <dbReference type="OrthoDB" id="62491at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0728460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="141" mass="16215" checksum="2B684A1D238629B2" modified="2020-08-12" version="1">MNRTGMQLAAIERRLNRMERDAPENDQALLAIVADCRRKLRDFQNQYQLLLTSELKIQSPPTTDFQTRLAEWLNDDTILRNNDEEDPEFSTLDGFLLVEDVDMLAQFVHDVAQTKTRRSSTSFIKTPSATNVCLDQPTLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WNI8</accession>
    <name>A0A6G0WNI8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_013356</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000171">
        <property type="protein sequence ID" value="KAF0728924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WNI8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016436"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0728924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="167" mass="16995" checksum="24927388D8BD887B" modified="2020-08-12" version="1">MKTTSVLVAASANSKPTYRRLPRDRVALRRRLAKVLAEPVCTKWWDGVVSDVKGISPPCDITGPDGTTFNTASFPWTIKTLFQFAKQNAANITTTVAPSAASNTTAASGAATTKAPTSGGAVTAVPASAVTAVPAVTATVAPVVTPKSDAFTAGVATTAIVVMAMMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WNJ7</accession>
    <name>A0A6G0WNJ7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Poly(A) polymerase</fullName>
            <ecNumber evidence="11">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Ae201684_013462</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Polymerase that creates the 3'-poly(A) tail of mRNA's.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 2 magnesium ions. Also active with manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the poly(A) polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="11"/>
    <dbReference type="EMBL" id="VJMJ01000172">
        <property type="protein sequence ID" value="KAF0728893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WNJ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014803"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000019">
        <property type="entry name" value="Nuclear poly(A) polymerase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000027">
        <property type="entry name" value="Poly(A) polymerase PAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.590">
        <property type="entry name" value="Poly(A) polymerase predicted RNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011068">
        <property type="entry name" value="NuclTrfase_I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007012">
        <property type="entry name" value="PolA_pol_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048840">
        <property type="entry name" value="PolA_pol_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007010">
        <property type="entry name" value="PolA_pol_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014492">
        <property type="entry name" value="PolyA_polymerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682">
        <property type="entry name" value="POLY A POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682:SF10">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04928">
        <property type="entry name" value="PAP_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20750">
        <property type="entry name" value="PAP_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04926">
        <property type="entry name" value="PAP_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018425">
        <property type="entry name" value="PolyA_polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55003">
        <property type="entry name" value="PAP/Archaeal CCA-adding enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) polymerase nucleotidyltransferase" evidence="17">
        <location>
            <begin position="18"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase central" evidence="16">
        <location>
            <begin position="214"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase RNA-binding" evidence="15">
        <location>
            <begin position="361"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="530"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="533"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="544"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="107"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="240"/>
            <end position="241"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR018425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR018425-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR018425-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF20750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF0728893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="626" mass="70515" checksum="28107F1CD75870C2" modified="2020-08-12" version="1">MQENVTTAPGTVLEQAYKPIRTTPPEPIDLEMSAKLQAYMDKNFPTETEKNIQRRTIILGDLRRIFRAWVKDVCIQRGVLEEIANEAGGIILVSGSYRLGVNEPGADIDTICVAPKFVTREDFFSSLKDILLKHSKVTNLVAIEGAVVPILTFDYEEINIDLQIAILDRSSIPDDLRILDDNILDGVDTATEKSLNGPRVTELMIKLTPNRESFIAVLRIVRRWAKRRGLYSNKLGYLGGVNWCILVCFINQLYPTAAPSTLLLRFFMVLSQWKWPSAIQLCKTYDAKLGLEVWNANFGANRFQVMPILTPAYPSMNSSYNVSIHSLNVMKEEFTRGLDVVKSIINNGGADWSPLFEPSEYFVDHQHYLAVEIYTIDPNDQQAWCGYAESRLRKFIESLAYHNPQLCRLRVYPKKFPLSFVNEPGKEEKHGATYFVAFDVDKQKIRGKEVRLDSAVEDFKINSLYRWPKRVEGMDVKITPLGWKALPEHVFDDMGGLKAAKEMRQKYLKRKKEEQAKLDAELAAATPTPPLAPAVALHHPQPLSSDDSMSQEDGSKSMSQPELNESASQSTPSSTPAPSPTMAPSPLVEKRAREDPPPMELPPAVLAMQNDSPPKRRKMKISFGAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WP49</accession>
    <name>A0A6G0WP49_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_013242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000169">
        <property type="protein sequence ID" value="KAF0729106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WP49"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012139"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025533">
        <property type="entry name" value="DUF4419"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31252">
        <property type="entry name" value="DUF4419 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31252:SF11">
        <property type="entry name" value="DUF4419 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14388">
        <property type="entry name" value="DUF4419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026337299" evidence="1">
        <location>
            <begin position="19"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0729106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="416" mass="46890" checksum="1EB99B732AE506E3" modified="2020-08-12" version="1">MRLWLLVSILLSFSAVYADITFAVSPVQLYKVQERTTNEMKTILIGLTEFKEQDCKTILQVHPHQYKTVPSTSGFVLGAIQAYSYHHNLVIRPDDIWLAIMVQFGFYVHGNAETLRGSLVKHQGRKEIIVNGLDTLHSADYGGMAKEMIGKMEEHLVDPSMKEWILPAFSTTTDHDRIAGSVVMMATMKTYFSYTFNLLCGIPNVTLLGTVQDWEGVQSRVENLRQFGGHMDEWVDVLLVVLDQFVMTAKGQVDVDLPKNLLRKRSYILSYRQLQIVATLSANIDKCIPKHLQRLSSIYPNRSSILESLGTSPFFNTIAQLKVGMIVFLSSTWYDMWPANMSDLCSAPLSSIKTSTVKYPAGMSFVLMIGNSDSVTRPQFVTDFVDPCQCPSSSKTQKTLIQPLIYAAKSRHPRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WPA0</accession>
    <name>A0A6G0WPA0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein unc-45 homolog B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_013140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000167">
        <property type="protein sequence ID" value="KAF0729162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WPA0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011577"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45994">
        <property type="entry name" value="FI21225P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45994:SF1">
        <property type="entry name" value="FI21225P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0729162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="909" mass="98896" checksum="B68F299F95598F98" modified="2020-08-12" version="1">MEQRKEEGTAFFKQGKWTEALASYQAALAFPDAPLEMQSVLLSNIAACQLKLKDFAGAVESCNRAIDMPKLPQGLMEKLLFRRAQGNMEIDQLTAAARDVKAVLQLNQGNKAAVQLLHTLQEKARADASGVGKALKSLKEAPTLDALRFLEHAPDSSVYRDVLAQQGEAVLWKCVYRYEDRAIGAGALRVLHKIATTISAAPILAAIDIPILTTFVQLPNTTPEMKKDDFALETAVTGLCGALSAYLLTQPESSQQALRALVDAVLNGLRSPEIPLQVAALDSLLSDIKDFAKLKTLLDELGIFPLLRSRADIFEEKTVSRIALVFSQVLAAFESQDSLVERIVQDNCILPIMVASTMAAASPGAILLCSVFLVNAKLGSLAIQRQTQFFPHLSSLLLAHTTKLAYQELVMDLVAFVAGSETGVACIPLELRVELGKIMQCDMDAVHLKLQATAVAALVKMSIVEKSFEADTPTGRAMIDIVLELMGRLDESHSRPSLVGSTAQERAVEALSYLITYTTVKDELVKQSGALNPLFSISATMPSNLLYGISYILHHLLTSESELKKQKMATSELTPDQYEQLQKALKQKSELDDGDSPAQVQARLSAVLAHPTSIKTLVQLLKTKSPAILDMAIQSALHATECVPVRGKLVQGGLLAALFPRAVSSEAAQQAIAKILITTNPNLIPSAQLLSAVQPLRTLCQNKNDAALLHFEALMALTNIASVSMETKARVLADQGLNAIQYLQFSDHALVRRAATECLTNLLPHDDVIEKVFCQPDKLRLWLAFASIEEAEEDFETARAASGALAMVSQYPEVCKVLLEQNPLTTFQAVLAESTSPELIHRHAFAVQNCLEYVASLKDNAEEGNMKATYEAQYLLLKPTVAALVKRTKEAEIRPIAQACLDMIDKFDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WPE3</accession>
    <name>A0A6G0WPE3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">vesicle-fusing ATPase</fullName>
            <ecNumber evidence="1">3.6.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_013001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.6"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.6" evidence="1"/>
    <dbReference type="EMBL" id="VJMJ01000166">
        <property type="protein sequence ID" value="KAF0729250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WPE3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015003"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.80:FF:000004">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04212">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00745">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MIT" evidence="7">
        <location>
            <begin position="19"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0729250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="96" mass="11337" checksum="89E1F723DB76B1D3" modified="2020-08-12" version="1">MEDEPVPQQPTPQQPPPQQYKPLNQAIDLVRQAVEEDRNLNLEAAFRLYRQSVEHFMVACRYERNPSSKQLIMDKTNEYMTRAEQIKTFLESQGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WPY7</accession>
    <name>A0A6G0WPY7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_012924</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000164">
        <property type="protein sequence ID" value="KAF0729423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WPY7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005972"/>
    <dbReference type="OrthoDB" id="10281206at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0729423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="374" mass="43101" checksum="B09AF80C80609FA3" modified="2020-08-12" version="1">MPRARATVEQKRLSQSNRDRRYRAKKKQEFQELDAVLRQLQEQHDNLKLVTLVDDIATAEIEANQLYKALAENQKLRSDAIRMHAICQALNDWVLSQVPSRELTPKASWMHSTLVANPIARVYGYKWFSDKIYHAAQRYFPQEPFGNTVDDAMRHVLHTDVDEDGLSNVGAMELHLQTTFFTNFKTAADLFWSFVITNNFITSSFTSSSWIEDSVDARLVYHCVLNPHTGTYNRRILRMYEEPNRVIITFASIADDERFPWRENELRTYGFAWATFERVSDKITISRFTTLHTAPVTARGPASLEQIGRLYGRSAHGIEHREAYIEQLRSIAERVYLNGFMHLQKSFTAVVEQAMQASCEDDDAALDLDIANLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WQ37</accession>
    <name>A0A6G0WQ37_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_012972</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000164">
        <property type="protein sequence ID" value="KAF0729474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WQ37"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010013"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF52">
        <property type="entry name" value="ADIPONECTIN RECEPTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0729474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="298" mass="33924" checksum="A6E7D0776900ABB7" modified="2020-08-12" version="1">MIYPSETVYGSLLHDPVKRRKDLATFDELDTLGFAFLSKNHFTRSGYRVHYSAKDCLLSLFQLHNETWNVWIHVIGSLAFAHLALQTPWTPLDAAADAIPTWPIVACLVCIALCFTLSAIYHLMYVQSPYWAKVFLQFDFAGILLLMMGTAVPMLYYTFYCDVFVRNLYVGMAFFFGATGFCVSFTAAFRTVTSLRIAVFMSIVMACVVVPLTHLLLTDGWHHPRVYMMLGPLLSSLPFNLPGVVFYASRFPERISPGRFDIWGSSHQWWHLCVVVAGILYYQQTLELHAWRSANPCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WQC6</accession>
    <name>A0A6G0WQC6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_012846</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000163">
        <property type="protein sequence ID" value="KAF0729578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WQC6"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071986">
        <property type="term" value="C:Ragulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024135">
        <property type="entry name" value="LAMTOR5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16672">
        <property type="entry name" value="LAMTOR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0729578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="99" mass="10358" checksum="61F7DDD2A43DFCBD" modified="2020-08-12" version="1">MTLTSALESIVGQDGVTGVVWNDAQGLLLGSQGDFQGVRSGFGALNVLISRAQALGPDDSTPILRLETTKRRVVVQKQSDGTVLAVSTSKDVDAIDSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WQZ3</accession>
    <name>A0A6G0WQZ3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_012510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000159">
        <property type="protein sequence ID" value="KAF0729866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WQZ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005409"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0729866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="149" mass="16710" checksum="6DD3D193E88D4C1F" modified="2020-08-12" version="1">MQPSASQTTMNTKRRPCTCQWTPPPARVVPGRSIPKKVIQAMVAAGAHKEHVPGGGMCVLRIDSVDSPAWQVYIDWVSIPGKGHPLAMALYYPWQFDLRPSKDKTLSVMDESKRIVNQFATLELDEFGQPSEYPFEYGTSARAREHSQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WRJ6</accession>
    <name>A0A6G0WRJ6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_012389</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000156">
        <property type="protein sequence ID" value="KAF0730093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WRJ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017258"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34894:SF5">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34894">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE RSMI, CONSERVED SITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="765"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="365"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0730093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="933" mass="104227" checksum="D9E667E1862F6ED3" modified="2020-08-12" version="1">MLISPRKKLSTVRDPDRASIAPPSTAYNLYPFQGLQSPPKLSNPSKSSPKRLQRLAQPVLAKNIEKETWVPLSRPFTPLSSVAPSAVASHLADEQHPHIKPDDLAQIEAWLDSFDQEAQSFTSYFLFCELKFQQSAVLATGRNVPNRLRTAVAFYCLQQASSIFGRFQSLLDTICTNLGSAIYSSFSALRRGPRHVTALECYQAGTTYFEQVDALQKENAALIASRQAFKDEVSRLQHEICRLETQSAALKDATASPLAAIAAFTKMALDGNEFNPVSNLAEREKMGYILKTFKSLGPIERIQVFLSMIELLDANPDVIFAMINTMPAPQREEVIERLIQDQMADMQQYVGPLAPSLSVFMTSQAQEVLRHVEAVQEDAEEARQELAKFQERIQDVLAGTSLSDLDIPHQEKGVMEALAAVVEALAREKEKVRRYEARVFTITAVHSKNKAQSETLWMDKCHDLEAKLEMIESEKQRLAEQLQSFLPADDAESTAAGEKIDQETQVSLEELQKSLLEHGNSQERRVTTQQPGGFVAKTHKSFVGLYTMIQEANYSVASVKRIVAKKRPLGLLELHQTIAGFYQSKMSQDIADDNMHRPRQGFAQMLLDSYTVFYGLRELAVSQLITLDASIRKFSPKSARVRIFGLLVGSLEPGSYASSVPATDFFLSVVGVLFNVGNYRLNEDKAQTNAKQLKTWLGDGMPGSSSCTNIPLDKLIPTIQIIFATSSVTVAFLDDLCSAPNDANEVDLDTAMEKILYFWLQLYEQQVATMHGVFRLGDKDTNGVLDFQEFSTIVHHFDPGMSRRDCLDLYNRVAGADNVIDKDEFVMGMINHLRDLELKTYFSTNYTLSTSSSSKTRAKGDVLGQPQMPFNPVRQLGVLLAKFKAAHEHMSHQVERSDPIVNWEEGIDPILERYTRTSSAMAPRPPTRLDPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WSU0</accession>
    <name>A0A6G0WSU0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha N-terminal protein methyltransferase 1</fullName>
            <ecNumber evidence="5">2.1.1.244</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">X-Pro-Lys N-terminal protein methyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_011930</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54712"/>
            <dbReference type="Rhea" id="RHEA-COMP:13785"/>
            <dbReference type="Rhea" id="RHEA-COMP:13971"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138057"/>
            <dbReference type="ChEBI" id="CHEBI:138315"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-methionine = N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54736"/>
            <dbReference type="Rhea" id="RHEA-COMP:13787"/>
            <dbReference type="Rhea" id="RHEA-COMP:13974"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138059"/>
            <dbReference type="ChEBI" id="CHEBI:138318"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54724"/>
            <dbReference type="Rhea" id="RHEA-COMP:13789"/>
            <dbReference type="Rhea" id="RHEA-COMP:13973"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138061"/>
            <dbReference type="ChEBI" id="CHEBI:138317"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. NTM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.244" evidence="5"/>
    <dbReference type="EMBL" id="VJMJ01000153">
        <property type="protein sequence ID" value="KAF0730506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WSU0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015874"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071885">
        <property type="term" value="F:N-terminal protein N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000025">
        <property type="entry name" value="N-terminal Xaa-Pro-Lys N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008576">
        <property type="entry name" value="MeTrfase_NTM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753">
        <property type="entry name" value="AD-003 - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753:SF0">
        <property type="entry name" value="ALPHA N-TERMINAL PROTEIN METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05891">
        <property type="entry name" value="Methyltransf_PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016958">
        <property type="entry name" value="DUF858_MeTrfase_lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="164"/>
            <end position="165"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR016958-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0730506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="270" mass="30549" checksum="1A247ACB7FDF13BC" modified="2020-08-12" version="1">MRVDWDELRRISEIVQRDLDAHGLDEHDDYESVFDMWESELADVQESKDDKPAVWYTSGAEYWENEENCPPNDQGVLGGYGHISPVDVEGSSAFLDHIQTLRPAMQRNLAIDCGCGVGRVVNNLLLPRYTAVDCLEQSQRLLQTIPSYVGPEKARIRNLYCMGMQDFDPKPGSYDLIWCQWVLGHLTDVDFVAFLKRCQAALAPGGVICIKENAINEGVPYYVDKDDSSLGRSSVYYKSIFRQAGLTLLAETKQEGFPDELYPVITYALY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WTC0</accession>
    <name>A0A6G0WTC0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_011825</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000151">
        <property type="protein sequence ID" value="KAF0730710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WTC0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000882"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
        <property type="entry name" value="FYVE_like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="START" evidence="6">
        <location>
            <begin position="55"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="5">
        <location>
            <begin position="272"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0730710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="446" mass="50907" checksum="F87A7FB6046CE674" modified="2020-08-12" version="1">MAPPKRRHVKFPLPQEYFPPPNFNETQKEILIQTGLEALTKLVRDTRLRGGPIDWILDYDEQGVQIYWGSDIGHAKETVFMSVTELQATLDEADEIHESDDDFSYREFSDRFNDDVCDCRIIETLAPKTPTHPHNYVGVKWLCFEPPPPVRNRDFVFVECRDDFNLNGVKGWARVIHSVDLPQCVPDFRRSLGLVRAKFVASGTVFKEIPSRPGYLQVLQLFNLDLGGKVPMWMQRIGMKKRTSSLVKFDKHFRAKRMSSLPLVDEEDLVRKSARKLCFLCQTRFSPFVTRHHCRLCGEVVCRHCSRRWELTDPRHVTRSVRACVKCSTETASSSTARTVRSEPADARGFRAVSMPKSCPVSPPPILEATCGNRRRRVVSAVAQRGLPNDDIVIPSSNLKVMETARDWTETLTNSATPEQLRALFQQMKKLKLEERFGSDTLAAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WUB6</accession>
    <name>A0A6G0WUB6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Medium-chain specific acyl-CoA dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="5">1.3.8.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Ae201684_011644</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; mitochondrial fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.7" evidence="5"/>
    <dbReference type="EMBL" id="VJMJ01000147">
        <property type="protein sequence ID" value="KAF0731099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WUB6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000616"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070991">
        <property type="term" value="F:medium-chain fatty acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051793">
        <property type="term" value="P:medium-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000010">
        <property type="entry name" value="Medium-chain specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000011">
        <property type="entry name" value="Medium-chain specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000007">
        <property type="entry name" value="Medium-chain specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF2">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0274">FAD</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7 14" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="17">
        <location>
            <begin position="40"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="16">
        <location>
            <begin position="155"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="15">
        <location>
            <begin position="264"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF0731099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="419" mass="45635" checksum="2792C937E73CDB9E" modified="2020-08-12" version="1">MSSLLRVTHRVSKTVPLARTFAAHATIDESKLNGLSFKLTETQREFQLLARKFAREEMIPKEKHYDQTMEYPKEIFDKAWELGLVNGHIPEKYGGLGLGALDGCIIGEELAYGCTGMMTAIEANHLALAPVFVAGNDAQCAKYFGRLLEAPRQAAYCVTEPGAGSDVAGAKTTAVKKGNSWVINGSKMWITNGGVADWYFVLAKTDPGASAGSAFTGFIVDANTPGITRGRKEINMGQRCSDTRGITFEDVVVPEENVLGSPGYGFKIAMQAFDHTRPPVAIGAVGLARRAMEEAKKYALERKTMGQPIATHQAIMFMLADMATGIEAARLLTYKAAYEIDCGRKNTMYASMAKRFAGDLANEVATNAVQIFGGAGFNTEYPVEKLMRDAKIYQIYEGTSQIQRLIVGKEVLTRPNLDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WUD2</accession>
    <name>A0A6G0WUD2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fatty acid desaturase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_011621</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000147">
        <property type="protein sequence ID" value="KAF0731073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WUD2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019603"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03507">
        <property type="entry name" value="Delta12-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32100">
        <property type="entry name" value="OMEGA-6 FATTY ACID DESATURASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="2">
        <location>
            <begin position="70"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0731073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="351" mass="40035" checksum="195B58C17DB41C07" modified="2020-08-12" version="1">MEDKKTVVFPTLTEIKHSLPNSCFESDVATSLYYVARSAALTAIFMTALTYGRRLVADYIILDAALCATYIYLQGVVFWGLFTIGHDCGHSSFSRYHSLNFIVGCITHSAILAPFESWRISHRHHHKNTGNVDKDEVFYPQREKDAYLPTRRIVYSLGFSWFVYLKVGYVPRTMNHFNPWDPLLIRRAGAVIISLCSWVAAVVGLAYLTYTLGVATMVLYYFAPLFVFATFLVVTTFLHHNDEDTPWYGDSEWTYVKGNLSSVDRSYGWLVDELSHNIGTHQIHHLFPIIPHYKLNEATAHFRRAFPQFVRQSSEPIIPAFFKTLNLFVRHGVVPDDAQVFTLGGSAKKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WUI8</accession>
    <name>A0A6G0WUI8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_011658</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000147">
        <property type="protein sequence ID" value="KAF0731115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WUI8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000601"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43948">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43948:SF10">
        <property type="entry name" value="MRJ, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="3"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0731115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="252" mass="28599" checksum="073590E9268B9CD4" modified="2020-08-12" version="1">MASYYEVLEVNEKATESEIKQAYRKLAVRWHPDKNKDPQAEEMFKKIGEAYAVLSDKVKREEYDYSRKYGYGSIPRPRSRGRGDPFEDNFHPFTFFDAQDLFHHFFGADDPFMQMPRRSSEKGRRSSRDPFGHFGGGFSMMMDDMFDDHMSGGFGGFGGFGNIMMSSSSFGNGVTYSSSLSSSSVRDRNGRLVTKTTSTIQHPDGRVETKTEEFVNGKLTNSTSNITPASNRLVGAGRMQLEADRPRRRSNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WUI9</accession>
    <name>A0A6G0WUI9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_011429</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000146">
        <property type="protein sequence ID" value="KAF0731163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WUI9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019797"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000997">
        <property type="entry name" value="Multidrug resistance-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000074">
        <property type="entry name" value="Multidrug resistance-associated protein 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="326"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="689"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="733"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="815"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="921"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="108"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="414"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="698"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1015"/>
            <end position="1246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0731163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1255" mass="138442" checksum="F9468779ED9EFA05" modified="2020-08-12" version="1">MASKDFSAFRSPDDRSRIIDDVDHQRHPIETANWVTKVLLLWVDPLILKGAKTPLTPRDTWKLRHQDTAACLHERFQTEWTIETHDQPTSPSFARALGRTLLKPTLNVTLGYAVYATLMLVQPSVIKTLVNYLQGKDNRADTGWAYGMAATLAVLAFISVTLMDYSHSLTVILGCNAKSIVMDAVFLKAISIPTVKSSGQVVTLVTIDSERLFAAYFTLPWIIVAPLTLLAIFVLIGTELGVLPSLVGGSAILGMLYLASRVAAEVGRIRGEIASVQANRVKLTNELLQGVRVVKMYGWEQCLEDEIERMRSKELALLKRFQIRRLLNDAMLAMAPVIALALCLAVYVAQDNVLTPAVAFTTLAYINVSRLPCTVFGGAVTSMSEAFTSCTRIGTFLQEAQVSTRPRVAHPSCLHDQVLARGSYRWQQDEPATLHDIDLVVEPRTLVMVVGPVGSGKSSLVRAILGEMHNEDGHEKGLQFAYASQDPWIQQDSVKANILFSRHLHEERYDCVLSACQLQADLATFPQADETEIGERGLNLSGGQKARVGLARALYDSSADIYLLDDPLSALDSKVATAVFRDGIQRLLGEKTVVLVLNSHYHLLRFAQRILVMEDGHIVGDGSFESLRDRFPHLFEHSTVVDPPPDDMLGTPSPLVNKPQDGALVAAEERKQGHVTFATYLKYFGSTGWNGYFVLSTVVASFVLAQLGLVLTDWYMGRWSARSSSSSTAATHVLIYLGLAFLSMGLLWSRSIYLLFLSTNCSKQLHRRVFHSVLHAPVHTFFDVTPVGRILNRFSSDLDQVDSMLPYAGVFFLNFMIQTVAVLIVCSVSAPFILVLYVPLVVVFYKIQAYFNRTAVELKRMDSVARSPVVNLVSEALAGLATIRAFNKTATFVSRNRDAIDHAQNLMMLHRTIYRWLEMRLDWLCTVVVAGVAFVLVASKDSLGITAAGLGLTYASQMSICLSRLVIGASLTDNLITCVERLDEYAALDHEGENDRLPSESSLEKMKPWPVDGNVSFESYSMRYRDHLDLVLRDVSFVVNGGEKVGICGRTGSGKSSLMVALFRMVEASSGCIKIDGVDISQVNLQTLRCRLTIIPQDPILFSGSLRFNIDPSQQASDADLWAVLKKVHLADRLEGGLDFQVAEKGSNLSVGQRQLLCIARALLRQSRVVVLDEATANIDLESDRLIQQTIKDCFRDVTMLIIAHRLDTIINSDRILVMDHGSAIEYDSPEVLLAKDGGAFAELAKHAQVAGSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WUP9</accession>
    <name>A0A6G0WUP9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Oxidation resistance protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_011484</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000146">
        <property type="protein sequence ID" value="KAF0731223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WUP9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009800"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354:SF62">
        <property type="entry name" value="MUSTARD, ISOFORM V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354">
        <property type="entry name" value="NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="6">
        <location>
            <begin position="135"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="37"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0731223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="298" mass="33353" checksum="8E2245A9431C6A5E" modified="2020-08-12" version="1">MVLISDITPGPSYFLMMHTPWSDYDPTSVERNLVLARRSTAPKRTARTKSPTKQTRSQSLQPTASVSSMEPEDEPKVHPLPAENAAMSADVKKKPHVLHRSMSEMPVSLCNKMAYEEPSLPQLIGGGPNDILSDPKVSKYLVPKLEACLPYRYRHKNWKLSYSLAQHGASLHTLYRRVRSHDASLVIIETDDGDIFGGFSMGTWTPSGLYHGNGESFVFTCVDKFEFFPWSRKNSLIMFADGETIAMGGGGGFAWALNHDMSQGTSSPTMTFDNRSLARRCNFGVINCEVWEFVFKFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WVV8</accession>
    <name>A0A6G0WVV8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_011234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000141">
        <property type="protein sequence ID" value="KAF0731614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WVV8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014856"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0731614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="398" mass="45561" checksum="2909DED0C2A3DE9D" modified="2020-08-12" version="1">MAESQTSAPNSNESVLVPEDWKYHPSNCVGTWGAWFQGNKTDPPLRHIEINAIQHKISQNKLRTTAKVVQKLIAATGFTEDMLENLDKEAFADTFHMAFEKLYPSKDPKMNIITLADEEPDSTSHITCFELWMKWFGAKPKPWRVLSVKQMPSELQQEHIGNSKFIAKLTEVALNLGLVETKSAVAKLSDAPRKALFSLAVQAFVAQCGPNCCLTPESLCTKAKPFLHVTLDPTFRLGDKPIFPFLPLRAMWRRWFFGHDNPTHTIPYRKIYEWHEDSADWVDKTRRGIDTFIQVALDNRIVQSIKALEAIQLEDELMKVFDKTFPLFRDQFVGKELSAIHPRMFSYSLVHRPSRSFWKLHPEFDGESKKAKKPRKKVSTLPPAAFRDTEKSTTCGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WW45</accession>
    <name>A0A6G0WW45_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Band 7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_011010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000140">
        <property type="protein sequence ID" value="KAF0731706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WW45"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002047"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08829">
        <property type="entry name" value="SPFH_paraslipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000004">
        <property type="entry name" value="Putative membrane protease family, stomatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050710">
        <property type="entry name" value="Band7/mec-2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327:SF18">
        <property type="entry name" value="BAND 7 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327">
        <property type="entry name" value="STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Band 7" evidence="3">
        <location>
            <begin position="28"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0731706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="334" mass="37549" checksum="DA517D5B4148117C" modified="2020-08-12" version="1">MAVSTGVVIAVGVVLAVLWIIVLFLFATSIRIVNHAEVMILERWGRYKKTLLPGIHVIVPIVEQVRPIAWRHRSRTIQNGDAPVISATTERVDMREHVIEFSRQHVITKDTVMIDIDALVYFRIVDPRLAVYKAQNIPDSVELVTQATLRNIIASMTLDDTFSSRDEINYELLSKVKHDVERWGVTITRVEIFDIIPPTDIKLAMEQQIKAERWRRSEVLEADGQRESMIVNSRGDAARMVLRAEGDRASTLLKAAGEAEAKMLSSKAEAQSMESIRAAITEPGVRAVDYLTAIQYLNVIRNLNKTTSDMRLVLLPMDTVNGVNELVKLNTAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WWM8</accession>
    <name>A0A6G0WWM8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA (guanine(10)-N(2))-methyltransferase</fullName>
            <ecNumber evidence="9">2.1.1.214</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_010885</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM11 methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.214" evidence="9"/>
    <dbReference type="EMBL" id="VJMJ01000138">
        <property type="protein sequence ID" value="KAF0731933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WWM8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018457"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160102">
        <property type="term" value="F:tRNA (guanine(10)-N2)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RlmKL-like_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016691">
        <property type="entry name" value="TRMT11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059073">
        <property type="entry name" value="TRMT11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370">
        <property type="entry name" value="RNA METHYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370:SF3">
        <property type="entry name" value="TRNA (GUANINE(10)-N2)-METHYLTRANSFERASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25904">
        <property type="entry name" value="Tmrp11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017259">
        <property type="entry name" value="tRNA_mtfrase_TRM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00507">
        <property type="entry name" value="N12N6MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51627">
        <property type="entry name" value="SAM_MT_TRM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 10" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3 10" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA (guanine(10)-N(2))-methyltransferase TRMT11 N-terminal" evidence="12">
        <location>
            <begin position="2"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA large subunit methyltransferase K/L-like methyltransferase" evidence="11">
        <location>
            <begin position="193"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00066937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF25904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0731933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="435" mass="49205" checksum="709ACFDF89B7B9D7" modified="2020-08-12" version="1">MKEYVVFFVHRHLDFRFPELDALLTMQSLRPEDCYTREQNPLSSPLVRVRLPSEAHAKFLSQRGILVKGVYEMWGQGKTYEELVRAVDEYEGKQVFLTDPSMSWKIQVDAFGLKLSMDEQKARREKFRDILPFAGPVMMKDPKLTFLILEEIGLDTTKTDPERIFFLRALAGGEKNRGRGGARDLVDMQTLKRRAYIGPTSMDAEMALIMCNMALIQSGDLVIDPFVGTGSVLVPCTTFGGICMGTDIDSRVLHGKNDKTIESNFHQYNLRVPDLVRADNSRSPLRCPNYFDAVVCDPPYGIRAGARKSGRRECGTDQEQAFTSTNKPKFGPRTIPDEYIDSHIPATQPYAAEDVMNDLLTFAATNLRIGGRVVYLLPTTYDYTDADLPTHPQLRVVANSEEKLTTKYARRLITMEKVAADDSLCQIARKDHRVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WWP7</accession>
    <name>A0A6G0WWP7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cyclin-dependent kinase 2 homolog</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cell division control protein 2 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">cdc2-related kinase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ae201684_010904</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">May form a complex composed of at least the catalytic subunit CRK2 and a cyclin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="VJMJ01000138">
        <property type="protein sequence ID" value="KAF0731953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WWP7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002641"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07833">
        <property type="entry name" value="STKc_CDKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000049">
        <property type="entry name" value="cyclin-dependent kinase-like 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF400">
        <property type="entry name" value="KINASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="4"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="305"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="470"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF0731953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="506" mass="57704" checksum="ACD66D80FCF931A9" modified="2020-08-12" version="1">MENYENLGTIGEGTYGVVLKCRHKETGQIVAIKKFKESDEDEQVKKTAMREIRILKQLKHENIVNLIEVFRRKGKLYLVFEYVEKTILEEIEKNPEGLEPSAIRSLMWQLVRAIQYCHQNNIIHRDIKPENLLVSKNGVLKLCDFGFARTLASAGAKYTDYVSTRWYRAPELLVGDVSYGKAVDVWAVGCMFAEITTGMPLFPGDSDIDQLYHIIKCLGRITSRQQELFRKNSLYVGVKLPEVTEVETLEERFPQLDKVAIDFLKQTVQDEPLDRWTCSELLKHPLISENAEFYEQQLRENIAKDVMDNMVKPRRPKKVPRPLKPPQTPNSLYGPISPPPSTPKGGIVSHLKPKSKSTKIEPPQYPISEPKRAEPRNHVNTKNEPFTSRFLPNLSIASPTSLFYTDVPNNEVLPLEVYSSQRLSKLKESVDPAMCISDENAQLIDHHMATRLSMTSHGSRITTPLKLRKCPMPSPKRAPEVPVSKINMPAPRTSHAHSRRDCRQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WX08</accession>
    <name>A0A6G0WX08_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_010725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000137">
        <property type="protein sequence ID" value="KAF0732072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WX08"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001050"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09083">
        <property type="entry name" value="EEP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF36">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="78"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0732072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="356" mass="41049" checksum="11170B5BA9F3DBBC" modified="2020-08-12" version="1">MDPFQSRLQQRAMRNPYKPHNDHTPFRAKMVLGLMVFVGLVMYLNGSSSTRSSQPKLRKDMGSPVALVTKTPTPMSVMTFNLRFAGANDGWNGWDYRKDHLIELINRYKPTVMGTQEGLKDQLAEIHSKLLGNYERFGVEREPNGEFEQIFYDADKVTKLDGGNYWLSDNPEVPNQKAWDAPCVRMVTWCRFQIKATKQEFVFINTQFDHMSERSRIKSSELIWKRIQEEWSLDMPIFLVGDFNTYRYTSVYKYLTTEEGPNLAEAWKTADKTIGDVSYTYHGWAGVDNDGEKAPNVVRAANHIDWILYRPRNMKVLSTEVITESRGGRYPSDHYPIHAELLFPTTDVIPASSSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WX16</accession>
    <name>A0A6G0WX16_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Queuine tRNA-ribosyltransferase accessory subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Queuine tRNA-ribosyltransferase domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_010678</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of a catalytic subunit and an accessory subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000137">
        <property type="protein sequence ID" value="KAF0732025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WX16"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006337"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008479">
        <property type="term" value="F:tRNA-guanosine(34) queuine transglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="entry name" value="Queuine tRNA-ribosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03043">
        <property type="entry name" value="QTRT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028592">
        <property type="entry name" value="QTRTD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050852">
        <property type="entry name" value="Queuine_tRNA-ribosyltrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46064">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE ACCESSORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46064:SF1">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE ACCESSORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="tRNA-guanine transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-guanine(15) transglycosylase-like" evidence="6">
        <location>
            <begin position="10"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0732025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="362" mass="40226" checksum="B678CCF2D24B3EAF" modified="2020-08-12" version="1">MERTMEILGISTPCYIPATIAGNMPHLTKDNCEKLSELKLVGVNFAELYASLAALEQTGMTFREFLNLPNDSQIIMSVTDVLSMPIARNTATHRSVESTNGRKKISPKEYMDAVNAYKPSVFIAIADEVDGTFGAKRQQTAMENSLLWLDECISLRGDASSRIFGVLCGGEVPRLRETSAVETCKRNIDGVVISGLGGCESLDFRHSTLQSYNKLVPTALPRLLINIGNPLEVLSAIACGVDAFMSSYPFIVSKSAYALVFWLDEGEAKLEESTETKINLRDKKYDRDLRPLLPGCPCFACTHHSRAYINHLLNVHEMLASILLYMHNLHHYYGFFGAMRRHIASGTFPAYHTAFEAHYNAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WXV7</accession>
    <name>A0A6G0WXV7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor SLU7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_010627</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SLU7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000135">
        <property type="protein sequence ID" value="KAF0732341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WXV7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001137"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030628">
        <property type="term" value="F:pre-mRNA 3'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021715">
        <property type="entry name" value="Slu7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039974">
        <property type="entry name" value="Splicing_factor_SLU7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12942:SF2">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SLU7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12942">
        <property type="entry name" value="STEP II SPLICING FACTOR SLU7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11708">
        <property type="entry name" value="Slu7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor SLU7" evidence="9">
        <location>
            <begin position="146"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="182"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="467"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="200"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="484"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="518"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="529"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="545"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0732341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="555" mass="62330" checksum="6F05BB665F19CA60" modified="2020-08-12" version="1">MNQAGDRMTSSDFRKKKEIDEARKNGTLPPEKDADGNLINPHNPDYISKRPWYLGESNASLKHQINPKKDQVLSMTDADALNIRAFKQTTQRKKFQKGACKNCGAMSHKTNECVERPRKIGAWKTNKDLAPDEVIVDVRSGQYGKLTFDAKRDAWLGYDAEEHQATIERFEKMEQVRKTKRIQEMNDTNKESGRAGGSDSDSDAGEDGGSDEDEFMDKEGGRVIAKRVSRQGGVGGAEMMITARNLRIREDTAKYLRNLNPNSAFYDPKTRSMRDNPNPDLKPDEATFMGDNFVRHTGDAVKLAQTQLFAWEAAEKGVIPDGALHPQATPSAAEFMRQQYEEKKLKLQQEKRAAMLAKYGEQTPAPPKELLLAASETYVEYARDGRVVKGMEKAVAKSKYLEDVLENNHTQIWGSWFDRRSGQWGFACCHSKIRKSYCTGEAGKAAASAIHEPVVHLEEAKTREALPLASGEQPALPQRSALYGERKDAPALDPAKMKQAEKKLKKLEASGKRKYNSMEDDGVDEETMEVYRMRKSQREDPMANLLSSDTLLPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WYG1</accession>
    <name>A0A6G0WYG1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CBM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_010328</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000130">
        <property type="protein sequence ID" value="KAF0732620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WYG1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013713"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026138231" description="CBM1 domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="4">
        <location>
            <begin position="272"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="4">
        <location>
            <begin position="315"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="188"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="221"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="271"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0732620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="353" mass="37878" checksum="6BDB7015132DA3AD" modified="2020-08-12" version="1">MVASIPTILLALTSTALGHGYLNNPMPTFFSQYPDITAFCGTMDGPSVLPGDQYNTSPEDNTKAFTSHFKASSYKTLKDLVVAHDGGCGQCGHTDASGKPQELPADGNVYWHHGQEGFTPSHQGPCEVWCDNTRVYQDDNCARNNPNGTMPIDLATCKKSALLTVYWLALHSPSWQIYINCARIAGGAAPSPPSPSKTSTPSSAPTSVPSMSPFTPTPSEDPYTPTPSEDPYTPYPSESPYTPTPSDDPYTSYPSASPYTPPPATPSPSSNGQAQGYSQCGGQNFNGPTQCVSGFHCNKWSEWYSQCVPSESQDRGVPTWGQCGGNGYNGSTNCKSSDVCTRRNDWYSQCVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WYH4</accession>
    <name>A0A6G0WYH4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_010287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000130">
        <property type="protein sequence ID" value="KAF0732579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WYH4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014699"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0732579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="209" mass="24956" checksum="6B8BDCEB06E61596" modified="2020-08-12" version="1">MVLNKWTDDETNNFLAYWNDHMDDYMKQKMSFYQAAARTLGTKEWISVKNRCEHLDRKYMKIKQKMSASGFGVRETDPQSLRATIKKEFKWYYDMDDLLCESTHANPLVVIDACRGSDEVEENYHARDITIPMAQNTVEETEMMPHQQKITGKRKKRDEAKEPSIMDVLLELGQQSMDLERSKLELMQKQFEFEMATRREEMEQRQRQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X0W8</accession>
    <name>A0A6G0X0W8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_009724</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000122">
        <property type="protein sequence ID" value="KAF0733484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X0W8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004741"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00302">
        <property type="entry name" value="cytochrome_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0733484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="23293" checksum="D307061C71B80C0C" modified="2020-08-12" version="1">MLAGHDTTSNTLGFVIGALASYPDVMAGIRAEHGKVVSKYGSLNSWEAVTELEYTLAVVQETLRLNTVAFAPLFRIADADDTVPMADGTPLFVPKGTTVQINFAAMHRNPKYWTEPESFIPDRFVQGTAAWKADLVLRGGKSHAFYYMPFSGGSKVCIGQKFALAQVQTVVAILVSKYDFIPTSKMDMRQAYGGITVAPVHAEMTVRRVVPPCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X1I9</accession>
    <name>A0A6G0X1I9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_009508</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000120">
        <property type="protein sequence ID" value="KAF0733663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X1I9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008753"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0733663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="154" mass="17945" checksum="D4DE722A270CB9FD" modified="2020-08-12" version="1">MIQHAVSHERASRNTKYHCLYGHYFLGLSISKLSTLYSKSPTTIASWIARYQRDGSVENSLPAAQIQRKFTLGMRQWLLDLYEKGPVLYLDEARARFTKRFNISISAFTIWTILNQSGLTWKVLERRAIQISYCDIIRYAEELLSIPWLLVNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X2R1</accession>
    <name>A0A6G0X2R1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ZZ-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_008995</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000117">
        <property type="protein sequence ID" value="KAF0734126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X2R1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008485"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="4">
        <location>
            <begin position="512"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0734126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="548" mass="61833" checksum="D4E8B584AD4C0F21" modified="2020-08-12" version="1">MSQKNDENTGSGTSLPGELVTLAMGFLDGPSLVACTSVNRLWNIQTHQSHLWEGVCLAKWPSLRSRGLPQIVSADDYDLVRLYGGSWKTCFLRNHQLNHTAVLTMKVPHSDLTTRSHRIPSEIILLDDYSFVIDVYAFDSAGSEVDGDREIAIFLRIVGDGGEKISCCAFTIVVDHPTDPSKSKLGHSWLQKLQHTRFDDMHGQMGWNNFSNLSDLKSNGFFDGHDDLSVSASIRLVPLSLHIYTDESFIQPEGFGLGSPSAMVDVPMCSTVKQIRDAVANNFPQLESPEEVDLWWFTLEDTVRQRSLIPQDDPDLALSVCGIPRFDSFYLDTYSMAHLYLDPSCEGSFVFIKVLDRQSGKLHCVGRLSLRHYSTPAAIFDHLSGLHPGVSRWLAVKENLPMLSAGNLVAVEGDLAQSDILICAEWHVNELEEDWRRDVARHLRRHLEQRWDQATVLLNQPLRHLTLSDLLTVGRSLDFHSHQILHAFNQCKKDARLTLAYMMEGRHLWQYCDMCGAVDFQGMRYRCTVCVEFDICDACHGKSLSRQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X4P4</accession>
    <name>A0A6G0X4P4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase C51 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_008425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000102">
        <property type="protein sequence ID" value="KAF0734948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X4P4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000158"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.10">
        <property type="entry name" value="endopeptidase domain like (from Nostoc punctiforme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007921">
        <property type="entry name" value="CHAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051705">
        <property type="entry name" value="Gsp_Synthetase/Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30094">
        <property type="entry name" value="BIFUNCTIONAL GLUTATHIONYLSPERMIDINE SYNTHETASE/AMIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30094:SF0">
        <property type="entry name" value="BIFUNCTIONAL GLUTATHIONYLSPERMIDINE SYNTHETASE_AMIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05257">
        <property type="entry name" value="CHAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50911">
        <property type="entry name" value="CHAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026030412" description="Peptidase C51 domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C51" evidence="2">
        <location>
            <begin position="54"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0734948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="236" mass="26226" checksum="9D5DC68ED08C9EAA" modified="2020-08-12" version="1">MARLDVSKLGVLLRLVLCVTVAVVTTNETTPAPWGTVIGVTSGVKVFSNDNPPPTDSYNFYPDDTDETNGTFTGLRWQCVELARRYLLVTQGVVFESVDDAVGIFSLREVINVTTDKRLPLDIYPQGSPVPPKVGSLVIWDRPGYYTPYDHVAVVINIQDTFIDVAEENLEKTSTGNHRLTIPAVFEFRVLRQLFMLSHATTSPTSLRSFLAGLPLLLARPVNERLCLLSIYLVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X5F7</accession>
    <name>A0A6G0X5F7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tafazzin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ae201684_008305</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a cardiolipin + a 1-acyl-sn-glycero-3-phosphocholine</text>
            <dbReference type="Rhea" id="RHEA:33731"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="ChEBI" id="CHEBI:62237"/>
            <dbReference type="ChEBI" id="CHEBI:64743"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:33732"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:33733"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion outer membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the taffazin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000101">
        <property type="protein sequence ID" value="KAF0735092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X5F7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017018"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000872">
        <property type="entry name" value="Tafazzin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497:SF0">
        <property type="entry name" value="TAFAZZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497">
        <property type="entry name" value="TAZ PROTEIN TAFAZZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00979">
        <property type="entry name" value="TAFAZZIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="13">
        <location>
            <begin position="102"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF0735092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="328" mass="36656" checksum="878079E661159475" modified="2020-08-12" version="1">MAARRWIRAAGASATVAVGVSAGALYLDSPIADLDDEEFRNFRASHSGDRFPEFVYSAGRSMLFFPATLVAKVYLGKLNHFTSRNEETLEKWVLSRPDHRALITVTNHSSTVDDPAVLAAMLPWSCVRPHVCRWSLCSQEYCYQKGPLLSTIFYGAKTLPVKRGAGVDHPFLRDLFEKVQQGDWVHIFPEGKIVQGGALGGREGPTAKTIGRLKWGVGKLIARADITPVVVPIYHLGMDQVMPQTEHHKLKSIIPCIGKRVHVRVGDPIYFDDLFIKYKKDRRQGESGDGYTWESEEAEKALYSAITLRIEHALLALERKCHADLAQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X7F5</accession>
    <name>A0A6G0X7F5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_007704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000092">
        <property type="protein sequence ID" value="KAF0735920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X7F5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012693"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0735920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="450" mass="52070" checksum="D54ED831E86C5C48" modified="2020-08-12" version="1">MADEEWDVMRDLHFLFASDEQLHDELVYMCDLLSDSTSDELPDDILAELKVNDAKPNIAGDKKKRRVRVKLTPENTSIGRQKREIYELRHQVDLLKERMVEVSQEVAQHKNTSEWEKIARDEFFEKNKSMRENEKLRAAVHEHATFIDEMKHILRKKPRLMLTTDLSSDAWQSCKLAAHASLRSAAIHAIADRQYARMQSKFIQAGVLNATDDILRANWFPQPDGNVLVEYTYHVPLAAPFHLIGEAIWKHFSSEKTYTEETSDTVEAIDALDDFTLYRTFRRVRVEDGWTVHSNIVYKYHVEEERKVVVWRSVLEDELLPHMARGNVHDESGWIQVTPLTPTTSRITLLLHVTADTVHDSKPSTVDELVETSRIIFDNFSFVQQPDEPGTFPGAPVKTAFKPNEMSFAKRTFVTRAKQMELNLNRVINEVVRKYKVGRISIETKEPNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X8J9</accession>
    <name>A0A6G0X8J9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutathionylspermidine synthase pre-ATP-grasp-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_007327</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X8J9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015215"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005494">
        <property type="entry name" value="GSPS_pre-ATP-grasp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03738">
        <property type="entry name" value="GSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutathionylspermidine synthase pre-ATP-grasp-like" evidence="6">
        <location>
            <begin position="57"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0736307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="429" mass="47537" checksum="F770ECA09765AB15" modified="2020-08-12" version="1">MSKSILPKFLNAVKKDLVLHTLNVSKQVGCSHYLDASLPYVRAFEAKYGPEICSSEHTTYYTITESGQAGIEAATNNLHKLFLEATDHVLNHTTSCAKHFRIPQSLWPKIESSWKNHKNDTISGRLDFALTDDGIKVYEYNADSASCLMECGYTQDAWSKGAGLGSLGRSNSSTLFDQLVTAWKAKHVEGHLHFMCDDDAEERYHSLYMKAAAEAAGIECHLVVGVKDLSFGADGITILDSQQRRIRNVWKTWAWPTVIGQYEASQAKPSTTRSRVEVMDVMLHSSIRVFEPLWTVLPSSKAILPILSQIAPSNPYLLRSTFDVNDIASFKGGYVAKPVMGRTGANVSLYNDAGELISATAGKWENDTIVYQEMALLPKYEDDCYVQVNAWAIDGKYGGTVLRVDESKIIGLKSSIYAMRVVGSNDHQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XA27</accession>
    <name>A0A6G0XA27_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_007044</name>
        <name evidence="3" type="ORF">Ae201684_007047</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000087">
        <property type="protein sequence ID" value="KAF0736890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VJMJ01000087">
        <property type="protein sequence ID" value="KAF0736893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XA27"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007536"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010640">
        <property type="entry name" value="Low_temperature_requirement_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36840">
        <property type="entry name" value="BLL5714 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36840:SF1">
        <property type="entry name" value="BLL5714 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06772">
        <property type="entry name" value="LtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0736890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0736893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="433" mass="49216" checksum="9227BC10EEA0FA20" modified="2020-08-12" version="1">MMRTLMSHPSLSADRSGEYEEKSAEWFELFLDLIMVAACSSISEKLRDDLSFHGFLYFSLLATLFTMTWMLYTSFHARFNEKSLLHYLFLYIWLVGLGGMVLAGKPGPTFTFGLLLVRIAQLCMRATMYIMLPRTRHKICVHILVGLVSVATLYLSLYLPPSWTITCYLIAIAVEAVGPLAIPPWVRWYRAIYFERIPMNIDHYKERMGSLVMLTLGEAILSAIIGFKDPSLLTVRYFIMMELALLVLFSMAMFYFAMQPSREFHALRRSLALGTAFTYLHIVLFPALLAMGVSLKFITNSVLKNESLDSTHVAWLFGSISASMFIMLLIRLTHFGGRRPAPSDPEHMKRITNANVWWTLVGFAPLVPIVCAWLLHKYSRDSINPITALVLAAGFNLVFTIIETLVMNVLVDSEPRVSENENARLLDETPDYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XAQ3</accession>
    <name>A0A6G0XAQ3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_006918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000085">
        <property type="protein sequence ID" value="KAF0737114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XAQ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004321"/>
    <dbReference type="OrthoDB" id="64460at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028118">
        <property type="entry name" value="Chibby_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14645">
        <property type="entry name" value="Chibby"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="50"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0737114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="151" mass="17047" checksum="412FC782940B0C70" modified="2020-08-12" version="1">MTSRAVKPGQLITSQGEDAIDETKEIAIRLNLPGAKLDFTNDWVVDTTELEQAKAMQATLMARIQALEQENQYLREKCDRIHDESNLDKFKSQLLVEMLAVSSLDEEKSKAEYIKEKLKVESLKQDMKALLEAAAKHNIDIKQFAVALKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XAY2</accession>
    <name>A0A6G0XAY2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_006405</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XAY2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010125"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04818">
        <property type="entry name" value="PA_subtilisin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22702">
        <property type="entry name" value="PROTEASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22702:SF1">
        <property type="entry name" value="PROTEASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="4">
        <location>
            <begin position="65"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0737228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="227" mass="25029" checksum="9817F718CDD6907C" modified="2020-08-12" version="1">MTCHFSLCEIEQWATNNAVYSMLQLHLLSQALVIESPCCHVAGHTFALFGPNMTDENAFKYVRREIVAAEPFDACEGDLQPDLTDKIALIARGMCNFSRKVLQAQRAHEIAVVIMDNQPRAPDEPWVIQMVADNSSNDVNILSIFVSYETGKSILGNISSCHPVLVTLNSTGSLINPRKDRSIGDNLLYGVVSIIIAMLKNVILHLHVSIDSPSGFNVVMNNHHETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XBD3</accession>
    <name>A0A6G0XBD3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_006627</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XBD3"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="42"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0737466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="180" mass="19948" checksum="BE9E05BA856C43C4" modified="2020-08-12" version="1">MEEREPVTSGHLTETGFFVEDADFEWDASFDKETDTSKGSMLHEINMNCSDKTLHAVVGAVGSGKSTLISAILGDARCTKGKLHRFGSIAYVGQQPFIRNATLRDNITFGRIFDHRRYQNAIRVSCLTDDLKILLGGDMTEIGEKGINLSGGQRTRVAIARVVYQDADIYLLDDPLNSWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XBT7</accession>
    <name>A0A6G0XBT7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_006737</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XBT7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016473"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0737582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="167" mass="17747" checksum="2FE479BB880754A9" modified="2020-08-12" version="1">MKSTRPRVDLRIVVDESDGEAKPTATSVAAHTDDAWWLAGYRLPPPGHLGAHSVPVVLNSSDKASSAGSQPTDDLFRTPTQAADSGLRRLLAPIQDEDDACSQAAVRATLHDVTIPSLRRDQRRGAVLPSIASLISISPPTAKRSATSDAPTDGLDAIRAVKHFKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XDG9</accession>
    <name>A0A6G0XDG9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">PIPK domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_005826</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000077">
        <property type="protein sequence ID" value="KAF0738266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XDG9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009269"/>
    <dbReference type="OrthoDB" id="70770at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00139">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF8">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 5-PHOSPHATE 4-KINASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="348"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="8">
        <location>
            <begin position="192"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="PIPK" evidence="9">
        <location>
            <begin position="418"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0738266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="856" mass="97453" checksum="3488125DF7397418" modified="2020-08-12" version="1">MDNRYRAPPSPYESQMHKDPRFHKRPVSSDDSDDDSDEEVPKNHRRRQPVPQTQGADVTTTPQVNNASRPPKSRRSLYLQIVMAIAAIGCFLLGVLLKYENLSPGIIWGSILTLLSVIAVLVSYASDPLSRQHPNPLVFWRTIADGFFVVRLLSEQFVRCLQYECSPLCKTFNCGCAVTQTIVPLPAGADTCVFFSGFFQFSLLASECWFLCMTLNLFLSLTNPFTDFKRNTRLFHMFSWGLPLLTAILLMSVDDFAGYSDFDTCWTNALRHTTVPNLTKECVSKGKDFILEDKFGSLQINYISWGFFYIPMVLFITVGLVVWFWTYNRLREGLPETYGVRKQSIDRARFLVMAVSVYWALVFAVYAAYLSMHDNQSKRRWKEVVNFLMAAKGYVDLVIWFHLNDFRVPRLSGLCSKSDKTIDIDLNPQVNAALRREVLFYTTSGIIQAVQQAETLAEDVKVQHLALRPQGVAETSDRKFTKTFHDYVPHAFRKIRQRFGVDNIRYLKSLSSTAKERLSEGASGAFMFFSGDGSLIVKSTSPEECHFLRSIAEDYAAYVVANPETLLTRFYGCHCLELYGQKFSFVVMANLFDTKQVIHSRYDIKGSWVNRKGGLPKRGKKVTCRHCNRKYVFESTAKEDFNCDVRLGGHEPNIVLKDSDLTQKLKLETSVAVTLYRQLEADSNLLCQYGIMDYSLLMGIHDVEFSVEVMDYGSRRHLLPSQTMPPRSGRRDANTVVGPAYYHLGIIDILQTWTFEKRMERFLKIHLRRVDGDGLSAIEPEKYKKRFQAKMADILGVSHLIAGTDTSPHDIYTAIQNSQMDIEASDGAEDNHPRSMPYLTHTGSLSDYASSGHIHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XDV2</accession>
    <name>A0A6G0XDV2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dimethylglycine dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_005763</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GcvT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000075">
        <property type="protein sequence ID" value="KAF0738411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XDV2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010969"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.110">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1400">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032503">
        <property type="entry name" value="FAO_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GcvT/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GcvT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCVT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757:SF2">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16350">
        <property type="entry name" value="FAO_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="2">
        <location>
            <begin position="44"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase central" evidence="5">
        <location>
            <begin position="412"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="GCVT N-terminal" evidence="3">
        <location>
            <begin position="469"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="domain" description="Aminomethyltransferase C-terminal" evidence="4">
        <location>
            <begin position="777"/>
            <end position="847"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0738411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="863" mass="94384" checksum="8629AC72C2CDA96D" modified="2020-08-12" version="1">MWSINIAKIRHAAARQQASSVIKGLPRYVSSIPTPANQAPDKSDVVIIGGGVVGTSIAYHLAKYGAKNVVLLEKTEMTAGSTWHAAGLVTYFNPGINLKKFHNYSLNLYKTLEDETGQSVGLHTPGSIRICTTPARMDEAKYQQARQNWHEAFQAIITPEEIAEKHPLLNMDGILGGVYTTGDGHIDPYSVTMALAQGARQHGAFICQYLPALKLNEKADGTWDVTTSKGTIHAKTIVNCTGFWGRELLQSVGVDLPLVSIEHQYVITNSIPEVKSLSQELPVIRDLEHSYYLRQERTGMLVGPYEAANLMKVRLDWQADGVPAGFGKELFPPDVDRILPHLEAAMERMPVLAEAGIQNVTCGPIAYAPDAYPLVGPLPHRKLRSVFIANGMSYGIAHGGGCGDYIARWVLDGEPPYDLTEIDPARYGKWTTPEYTAAKARESYGDNNLITHPIVDKKAARPTYRITPIHEKLAKDGAQFGHHSGWEVPHWFAKAPAEIGHEPSFYRSNSFEPVRRECQIIMEKVGITDLSSFATYEVSGASARDFLEYVGSNTIPATGKISICHLCTPKGKVMGELTITAIDENQFYVVTGAGSELHDLRWLDEHSVGFPDVKIENTSDETGVLGLAGPHAAQVLGAVTNGDSFPFMKYKTATINGIDVRVLGLSFTGEAGFELHLPLKDLDKVYHDVWAAGKPFGIENVGSFAVNSLRLEKGFRVWGREMNMDTTPLQAGFHRFVKANKPVPFIGQAALQAELANGSTKTLVFLHVHTDQPAPGHKPLDAWGNEAVWHNGSVVGYTTSGDYGHIVKKSIAFAYVPPSLAKEGETVQVELIGHKYDATVHLQPFMDTQPTRVRKAAKKAAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XDW6</accession>
    <name>A0A6G0XDW6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_005770</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000075">
        <property type="protein sequence ID" value="KAF0738418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XDW6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017738"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF98">
        <property type="entry name" value="FI18310P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Peptidase S1" evidence="7">
        <location>
            <begin position="168"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0738418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="405" mass="43673" checksum="3C1339DC4CCC74E3" modified="2020-08-12" version="1">MDGNDNDNKSKCSDDKPSNERSDKSSHEYSHHHRVCRSTTTTTIPRSNNGDTVTNNDYIAPSTSNFVASSVNQSSPHNNHASTSRLSPRASIIVVRFYHVGLRFWLCIKPVTINDTASLLRCNQSQSPPSLAEHLNSFHLYSFHVGRIFLVVLFGLATTVAATIHVDIVGGEVVPASMFPEYIALLVDAPHHAVTCTGSLIAPSYILTAAHCVAQMSWAYLGSNSANGDDAIELVQLVNRIVHPKFDLGYTAYDVALHELATPSNRTPAAISWDDDRFNAPGVKAWIRGYGKMSDKGPIPKTLLQAQVVIQPYTTCVAQLGYVNAETMICAGGGKANDTCAGDSGAPLTVFKDGKEQIVGITSSGAPSCVTDIPSVYMRMSSVKSFIDSVIPPPKSTCFERPTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XDZ7</accession>
    <name>A0A6G0XDZ7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like HEAT repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_005786</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphatase 2A regulatory subunit A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000076">
        <property type="protein sequence ID" value="KAF0738349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XDZ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015380"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054573">
        <property type="entry name" value="PP2A/SF3B1-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051023">
        <property type="entry name" value="PP2A_Regulatory_Subunit_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22646">
        <property type="entry name" value="PPP2R1A-like_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="115"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like HEAT repeat" evidence="4">
        <location>
            <begin position="226"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="233"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="355"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0738349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="625" mass="69304" checksum="0520F37B4B0E8BCA" modified="2020-08-12" version="1">MAFREDLSNHPMGSGGATFEDLAIDDTLTDLERVVRYVHSNIALQRVIHVRMLEETAIAAGFEKTCEAILPVLEPLVSDVEFVVRQHVAGQFPGLCKHLIETGGNAGYKIVLDKMMPMVNILLTDVQAEVRHIASESLVTIAELIKPEDQGQHVLTLVLPLAHEDEDEQMRITALILLNKLAVFLGNDLCCQFCVPEFISLAEDPVFRVRKAMALNCFHVCSTAGPQVTQERLLPAYQRLAKDDIWGVRKACAESLSDFSTTLPSSARLESLEPLFSAFVVDASKWVRIAAYQQLGPFIATLPRVSDVLSTAYANTATQPSTLLLGGAESDIKFHCAFNFPAVAMTLGRENWSKLAAGFDALSRDGFWKVRRTLAYSLHEMAQILGPEFTEEHLVPAFSYFLDDIDDVKMGSIQHFAEFLTHVEPSTRSRFLPELAKFGLLQDSPKFKLKWRHRALVADQLSVFCTVFSPDATFDVVAPLVFQLAQDDVACVRESSLAAMPSLYAAFTSSPERSKAIVDRMVALKESTSYQTRQIFLRISRAFLLAQSGPLEALLPAALELASDLVLNVRLLLARILLEVAEASKWTVPKTYAAVAAINRLKEDANPDMQEVVCQLKVHLEQVGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XEA7</accession>
    <name>A0A6G0XEA7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_005757</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000075">
        <property type="protein sequence ID" value="KAF0738405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XEA7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010962"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005216">
        <property type="term" value="F:monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46726">
        <property type="entry name" value="TWO PORE CHANNEL 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46726:SF1">
        <property type="entry name" value="TWO-PORE CALCIUM CHANNEL 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="476"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="524"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="554"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="616"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="703"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="7">
        <location>
            <begin position="140"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="7">
        <location>
            <begin position="490"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="817"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0738405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="843" mass="96399" checksum="364AAAA75F401DF1" modified="2020-08-12" version="1">MDKRDEETSPPLSESTPLLSGNVQIEVSNSLKENQDKWKSLMQIDETGNTAQEMADDITDALEALKFFDDGDFPRTRADIARSISLSNVVYSPMNHVVHQTVDVDKYLVAASFIQDGIHGRKIGYRIDAQALRMVQWFHSLWYRYLFTAISVGCCALAFVEDVHGSNSYLWLEIIFLTAFSLDVYIRYAMSSDKTKAQFRKREPWATLRFGLLVLTFLDIGLNLCGVPFAQMRYSRIFRPFMVIARRRNIRVVFASCIRALKDVMVILALLLCVVMFFGLMGFLLFADSSVMLNVPYFATLGNSMYNMLLIQSCLPVLMTVMEPYYIQSQWSSIYFVIFVLFTNFFLVKLTIAVSYRTYKKNTEKMLFKRLQKRKIALSKAFELLSDDAAMADPLAIPTVSIESWLKVCQHLKPEWSAEEAEVVFFSSDIHQTRSVDFTQFIQLASIFVNAHVSQRRRRSTFVQGMRVWQHRARNVLLAQTTIYGCPVIYMEVFVGFLICLSVVQATQVNNYALTKSLNHTWRMVGIVLLSLFTVEIAAKLFAFGREEFFNRPFCKFDIVVAGVGWLFYVLTSVNPTFPIVFYDLALAVRSLRVLKLLNLIPPFHNILWTLNRIMPLIWQLTLVILAVVYAFAIVAQGLYGNLLVNFPIARKAQAAAWYLHKEEFQLDTFEHCLVTLFEEATLAGWNSIMDAVYLLTQRSTTLVFFFTYRIAISNILLPIFVGFLVESFSSNQKPATDEEKMDQHTTTVVPSVVSAAPVKPVKYRMTFNRRTSDVQSAMFDFSDKKIQADQYERKIKALVATLDERNEEINQLRAQLNASSVSTEDSATTRSTLSPMPSSEMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XEQ9</accession>
    <name>A0A6G0XEQ9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ethanolamine kinase</fullName>
            <ecNumber evidence="3">2.7.1.82</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_005336</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.82" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000070">
        <property type="protein sequence ID" value="KAF0738714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XEQ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001979"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05157">
        <property type="entry name" value="ETNK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF66">
        <property type="entry name" value="ETHANOLAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0738714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="432" mass="49457" checksum="B9083896DC604CA0" modified="2020-08-12" version="1">MPTGLEPFFDKIRPVHFGIVIALSTCVCIIATYQLLRPKEKKQTTSRGIKMSSQVTYLNNSKAILDYEVGGRGEDFEFDDCKHVACIIYPPFKNANHDDIKIKIICGGITNRLYRLSWQDHSVLIRLYGEHTEDYIDRDIDNATFAELSRRGFAPTYHGRFSNGRVEGWVDGAPLEPAQMGQSDILELIAKEVGKLHSMDMDFPKSPRLWQKIHVFEDLASKVSFDDPIKQDNLEKLNLNQIKQRVQWLQSILPSPKNDHGKKLLESLRGSPMAKLAAEFVQESVFSHNDILSGNILYNPSWNKVQIIDYEYGSYNYRGFDFGNHFCEHCGFDMNLNDFPPKEKQFLFYKAYLSTASPALLQSLTRDGNLDEFLVALYDAGNLYALASHLFWGLWAVVQAGSSSIEFDFLDYARMRFDALEMHLDLFCPKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XG55</accession>
    <name>A0A6G0XG55_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Dynein heavy chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">Ae201684_005219</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000067">
        <property type="protein sequence ID" value="KAF0739036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013379"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein 1 heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000006">
        <property type="entry name" value="Cytoplasmic dynein 2 heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001810">
        <property type="entry name" value="Cytoplasmic dynein 2 heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000003">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000598">
        <property type="entry name" value="Dynein cytoplasmic 2 heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001685">
        <property type="entry name" value="Dynein heavy chain, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054354">
        <property type="entry name" value="DYNC2H1-like_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703:SF22">
        <property type="entry name" value="DYNEIN CYTOPLASMIC 2 HEAVY CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22597">
        <property type="entry name" value="DYN_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="8 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein 2 heavy chain 1 cytoplasmic ATPase lid" evidence="20">
        <location>
            <begin position="176"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA module D4" evidence="16">
        <location>
            <begin position="331"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain coiled coil stalk" evidence="15">
        <location>
            <begin position="590"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain ATP-binding dynein motor region" evidence="17">
        <location>
            <begin position="947"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain region D6 P-loop" evidence="14">
        <location>
            <begin position="1411"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA lid" evidence="18">
        <location>
            <begin position="1551"/>
            <end position="1683"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain C-terminal" evidence="19">
        <location>
            <begin position="1693"/>
            <end position="1989"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="630"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1118"/>
            <end position="1145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF12777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF12780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF12781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF18198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF18199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF22597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAF0739036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="23">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1991" mass="223905" checksum="AF81E9AB0054C964" modified="2020-08-12" version="1">MQRGMHIVAPWVDKMMPFIVVGPEGAGKNMLIRQAFSSIKGVSFSVLHCNAQTTADHVIAKIAQSCSLFSTNKGRVYRPRDGDRLVLYLKDINLPKPDQYDTCMLIAFLQQLITFEGFYDPNLEFLGIERVQIVASMNAATTVGRHVLSTRFTAIVRVAYMDYPSGDELVAIYSTFLEAVSALQDNSNRDKLAKSMVELYESIRSKFSVDDHRHYLFTPRDLTRWTFGLLRYDLSGEEVLDVLAYEARRLFRDRLVDADSKSKFDSALNTILKTQWRHHAKLQDSYFTSLGQKRPEDELAIVPLRRMATEDFSQVIAQGMVLYEREEKELHMLLFEEILDHVAIVERILTEAGGSMLLIGQSGVGRRTATTLISHMLGYKLFTPNLTRNYNVVSFKVDLKAILISAGVEGQHSVLYLEDHHFVEDAILELTNSLLSAGEVPGLYTHEELESLLGPLKEKMMESTIAYRTVYEFFVARVQMFLHVVLGMDARHSQFVRQCESNPALYTRCTIVWMGEWSANSLKKVPEMLLASSELLQDEVQKVHLLNMVHIIYDSVQTFGATPREYISFLQTWNELYTEKSKQLVTEVKHLKSGLSKLEEASATVDELSKSAVVKKKELGAAQVSADEAMDEIKRALDRASGNRREVEDLKKQLAKAEEATNGRKREIEDELSEITPVLESAKQAVGNIKSDNINEIRSLKMPPEPIHDVLSAVLMLLGIQDTSWNSMKKFLGNRGVKEDIQNYDSRRITPEISKAVTKLLKAKASSFEHENIYRVSVAAAPLAAWVKANMKYSIVLAKIEPLEADLAEAKLSLEASQARLLSCESELKAIDVKVDEMKSLFGEKTKEAEILRVGLERAESTLQKAQGLLGKLGGEQTRWSAQVKELENRVVELPMKLLMASGFTTFLGKCSETQRHSIAKGWDASTDSSTTFEYRKLMSTESELLTWKSMGLPADNLSMENGLVVHYTKERTPFIIDPANAATGWLQAHLAKDASRPLSVVQSQEPRFVSLVEQAVRFGKTLVILEVDFVEAYLYPLIRRDLNHQGPRFIMRLGDKDIDYNDNFRMVLVTRNPDPELPPDAQAIVNVVNFTVTKSGLEGQLLGVTIQNEQPELEAQKSELLRSEEEFKVQLASLEKQLLEALATSEGDILDNTTLIESLTRTKATSADIESALQKSATKSQELDEQRAIYAPFAADGARLFFLVKALHSVNHMYRFSLASFIGLFKATLTAKMDVATVKERIQRLSPMLETKVLMYVGRSLFKEHRPMFGLHLIHGMHPDAFEEKEWEYFVGDLLSDIKKEAPLPEWAAADRRDAFTLFVETFPKLTAQLKFDSPDLWLRWSKAVDCEVAFHQKIEKALSPFQRVLVVQALRPDRLQSAIQNFICTLLKVKSLTPPALDLKDLCTSEASSTTPVLLITTAGADPSKELEEVATEVVGREHYFEVAMGGGQQEKALTLLRSTAENGEWLCLQNLHLVVAWLVVLEKELNSLTPHHKFRLWCTTESHDAFPLILLEQSLKVTFESPPGLKKNLQRTYASFSVDSPSPVQRMQLLFLLAFFHAMLQERRTYIPQGWTKFYEFSFGDLRAGLNVMENLSQAKEIDWQTIHGLMENAIYGGRIDNPYDLRVLRCYLQIYFGTDVVTGKANLTKGLKMPSSDSRDDFVALIDHLPDADPPRTFGLPDNIERSVQRTASSAVIAQLRTLTSSEQASSKFDREKWRVLLGPLIENWTKLTASFNFEAASAHGSKDNKVVTPVEAFVAMENAAATDLAIHVNNGLQSLKKVIYGTGLLTPAIQMIAAALLVGQVPAEWSNRWEASEVVQVWLRSLALRKRALNEWKEDCAKGTLLSRPLDLSDVLQPGTFLNALRQQAARTLKCSMDGMKLLSCWEKDKTTSGSFEWYAIGGLLLQGASFEGGSLQESTSDAQELISVPTCYIAYTREDEREPYAKDTYIKVPLYYSTSRERMLVEISLPISGDPSKWIVGGVALFLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XH10</accession>
    <name>A0A6G0XH10_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Clu domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_004699</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000063">
        <property type="protein sequence ID" value="KAF0739516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XH10"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018959"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15466">
        <property type="entry name" value="CLU-central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033646">
        <property type="entry name" value="CLU-central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025697">
        <property type="entry name" value="CLU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027523">
        <property type="entry name" value="CLU_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT EIF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13236">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12807">
        <property type="entry name" value="eIF3_p135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51823">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clu" evidence="2">
        <location>
            <begin position="35"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0739516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="876" mass="97449" checksum="7A57CD0DF6D4A738" modified="2020-08-12" version="1">MGWQGSSEEFAVIQQALDPQLIGKIPRVLFLSWARAHFSAPEPPPPAPTPAPVQATPLATDWNGLYWELLHNQSSGVSQGLSVAHLMKEFHLAATSLARSVIEEVLLHPASSSAVDPPSPQHINLGYMDCPMFPSNGLCAFIYLPATNLVTKTLGHDVRSARVFQVAVDAVGTDAITVPLQCLIDYLGVRVLVVADLASTEPFEMNRNGAVSSAIRQVLEYLHTCISDDSLDVTLPPETHVVKSNDRIIVTKLRHLCAPDVLQEHDDEAALCAWKLRPEYIRKYHTPLYSNAYRGNYGKSHDNVVACASHYLQKSIIPACVQRLESNPHLFDSGALTALMHREGINMRYIGRMYEMTNVKYVRRFLLTEMIARAAKVLFRAMIREGPAHSRAIAVDFFNVLCGASKESIEFYANEIEPTVDLKFGAHIKDCRQELHIPQLFVALQYHTGVYFVHSILYALGQIAHPFRASHIQSLEPSVTMLCSTTPKCQLTIDSIDSDDNEDLESKLQNAKLALAIEQACPTNVRHVHLCNLLVQAAELSLRLNNKGDAETFATLALEEGPSTHAVLARAHVVLMNLHHEHQDLQSLLESFEKAVEVVSWHLSATHPCMLDAYTTMADIWIQRSEWEKALDNLDLSTAVVKESYGRFTARFASIRCKQGGILKRMGDLEQALSMYEDALLVYENIPSTLKDRANCCSAMTDVLVEMKSFHTAYNMAMQAHELRKECSSEDLEGLLSSWMTLGRCSRLLDDDFRALECYKSALALAKAKQTSIQNVTEKIQEISRLVLALVFQTLFPEAKQCVEKIKLKGLDVTSELIAFVVAQINALDVTPYVEMIFSDLLGDDSSPSPPIFEHYSSELQLNGVLHLAAVPPDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XIM6</accession>
    <name>A0A6G0XIM6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_004370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000054">
        <property type="protein sequence ID" value="KAF0740132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XIM6"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0740132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="73" mass="8568" checksum="C17BE101952C0526" modified="2020-08-12" version="1">MKYRFVEGNDLKFFRLGLGWRCLYRALNVADLVSSRMPDSYVASWTWYSSDFNCVGLLHTQQNVEYIINAYAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJA9</accession>
    <name>A0A6G0XJA9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_004180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000052">
        <property type="protein sequence ID" value="KAF0740445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJA9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005296"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF105">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08007">
        <property type="entry name" value="JmjC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="1">
        <location>
            <begin position="228"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0740445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="571" mass="64270" checksum="83C94F5CE407C252" modified="2020-08-12" version="1">MAASKRKRDENDSAFSGSRFSFNFSGAIEDTSDAASVAPVVAESHPESASIKLQCAVGDSVLTPGTLISIDWARSSWLKLYVRVKDTPEAIEGWVHPQYVSLPRHRPWTFNADDETWCFDYVFDPTFAGCRLPLHFSTAPLIIEPNLQSLVWPLHLSTFQREVFSKKAIVVHGSTHRLESLREELYDFDVNELIQNASRTIAWLKQAAPPHKMQYLDVSSPEIAAACYASGHSLYFNPSPEIQERYISALCSDLGLNFTSTLDGSYGGDIEIFAVQSKHHTPWHFDAQHTFTIQLKGTKQWSFAKAPLTDPMTNLHISSSNTTSVLEDTLTHAMCGAAQLTPPTTDFDTVTLRPGSVLYIPPGYWHNVTSFEEGSLSMNFSIDGSRWMDLLWNRLMPVLAGKPEWRERPNFIQGAENARQQWKARLHTLAETIQKMADSADLVFPDAIFQEAELESNLSLDRSDIEVRVKAHDKFKRTPVHVAQLVTLKPLEYTIAMGGYRKYADGCKAECQKTLVIPDGLKPAIEELRVNDNIWTLESLQAQVDDAALHPKLYRLVEYLFQCGYLQTIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJF9</accession>
    <name>A0A6G0XJF9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_004163</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000052">
        <property type="protein sequence ID" value="KAF0740428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJF9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015906"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052050">
        <property type="entry name" value="SecEffector_AnkRepeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586:SF3">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0740428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="316" mass="35606" checksum="A749FCCB93740250" modified="2020-08-12" version="1">MQLAAAVLVHHGLFRHIVGFQEGIPKEFIVFSKLRYPIHSWLLADLATIDRRVSTFRSVFSWWFCLYGISGVRRLCDLWPAMQTMASVYAAVGGDLELMCVLNPDPYNKRTISICLADLAARHGHIQILRHLLDKGHMCSCRALDWAATNGHIEVVHFLHELYPQEGGASTDAMDGAATNGHLDIVHFLHDNRQEGCTVAALNLAARHGHFQVVEFLHFHRQEGGTTAAMDSAAKYGHLDIVKFLHAHRNEGCTTKAMDGAIINGHTQVVQFLHEYRTEGCTRDALDRLVRDNLFYYLHLPVVQFLLAHGYNLKHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJS1</accession>
    <name>A0A6G0XJS1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_004118</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000052">
        <property type="protein sequence ID" value="KAF0740381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJS1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004360"/>
    <dbReference type="OrthoDB" id="6130531at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007157">
        <property type="term" value="P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013111">
        <property type="entry name" value="EGF_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051216">
        <property type="entry name" value="Teneurin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11219">
        <property type="entry name" value="TENEURIN AND N-ACETYLGLUCOSAMINE-1-PHOSPHODIESTER ALPHA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11219:SF69">
        <property type="entry name" value="TENEURIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07974">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026081510" description="EGF-like domain-containing protein" evidence="5">
        <location>
            <begin position="22"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="79"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0740381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="221" mass="23494" checksum="A95CA75A6A5A640F" modified="2020-08-12" version="1">MKLLTSVAAALVVLFFDPTAAYCPNGCNAQGTCGANDKCTCYLRNDDFTVAQEPMFQGADCSLRTCPRGTAFVDVPTANNVAHAMTECSNRGLCDHSTGLCQCFPGYEGMACERTSCPNQCSRRGICLTLSTIIAQNPNSPTSYVNAWDAQKQLGCVCDLGYRGPDCSIKECPSGPDVLLGHGSSNGRDCGGRGKCDKQTGTCVCFPGYYGTYCSFQSTVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJU8</accession>
    <name>A0A6G0XJU8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Translin-associated factor X-interacting protein 1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_004022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000048">
        <property type="protein sequence ID" value="KAF0740648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJU8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009223"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="313"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="442"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0740648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="858" mass="97642" checksum="F34324611727A0AC" modified="2020-08-12" version="1">MEVPLFKVHAELNVDLDEATLRLPPILSEPSKLFLPSTKSVVRLKPTATSGAMTARERPKPDLTMRRTKREVFMPVATQSLNHAQHEQLEHILHAFETDAAHHCLRPPDRLFWYFELLDQVAKTASPVQHALQEIQRVLCDVVYDCAKLDVPRATRGLEFAHLVKQIHHEAIDKELARLEAAMKEQVDHAPWHDLQASMEQTKIQTSRAMELASLEAVLAKAKESQAKLLAEVAAHAESVRRDEELYEHLLGDEVALDRKSSFHRLQLLEAAKMRGQVAEKAHALRDDFGKTMFFLHEKEAQAKEHDAIASTIDDLKREKAHLAAKSEKLTSDIQALEAQLAADQRLVATKREELRLAELDLEEVNESSTDLQRSHTPRPKWDAVFKTLPEVAYVDPVNQAASRDGKVRRRWAKQGRTQTFVKEMCHWLQRIQGDCVMSLQLARLTNESEAARLELSKLQAQVESLARRQRRQVQALPTRGTGLGSLSAVAKTLTAAKKLLGATAGFSNSTEPYTGPVKDYITALGTTPEVPQFLRHTGRVRNRHMTKTELEKIIRTTWSGKRAKEAHMGIKIPLVGRHFDRSVAHAPMQDDYLYEVLKTKFTIQTVIAEWGYNILHSLKAFSWDSEVELFFLCLTGAVSETIYDDQELMLDECRNVLLRLNESYFDAELKHDPKRVYLNDAMLTLHNFFPMKTPLQLKSIERELLREAKSKETSVHGSAGEILIAIDELLPVKHRSSTRGYFLKVLRTQHFKEIQDYLALLDRKIREADVHNIGRVEIQSIKEAMQAIDVAVTDTWLADCILRGIPKRLVGHMGMTTVVEYKTFFKKMNLKLMKHSLNFFPKAQIVSLHSTPRTCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XKE1</accession>
    <name>A0A6G0XKE1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">No apical meristem-associated C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_003847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000043">
        <property type="protein sequence ID" value="KAF0740806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XKE1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019870"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0740806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="12726" checksum="1D6A4B049294FB78" modified="2020-08-12" version="1">MDSTPKADKPKVVKRSSSDQEVNLSNESEQNTPQRPTGMKRVKSEKTQEFLLVRQVRATEAMVDSAKATIQVTQEQNDIQVFSMRFDPSDEQAAEFLKLKRENILQRLRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XLG8</accession>
    <name>A0A6G0XLG8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_003638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000041">
        <property type="protein sequence ID" value="KAF0741066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XLG8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005640"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="329"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0741066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="439" mass="49017" checksum="B6875F4E1316E727" modified="2020-08-12" version="1">MDNPDAVRAAPAVQFSHDLDETKAESAAELPEAIEETPTLSWETIRQWPKRPTPTQTLAVRRLVAKYKQRVPSSDEYEHLCRSETSNGTFEGEHSARTCGVTTTAAGKSIAMQSVDQFYFGVVQDGIDFIYEGQLDVNVPHGYGVGSFANGERFIGVWADGTPAGLGRRMAKDCQHGWFYGMTAVYLHQERPVVVALPPPPRSKEQPHLGLYLVGERLETARLKRFRQVFDRWLAVVCSEAEATAIECRTVAFSAWANGCKAQLASVRHEGMRLQRNDQNQKLVAKVRAFVAQEAAATEKNELRQARLRHATLVNTTTVACLGIERRSAELLQQDLAAIESELTTAKAAERRCLALQREYSEIRRRIHEGKVELNALRQARRAPNAVRKPSIMPRRQRRSSAKIYVQEADEDAISNVCGIDGCNCHIAKDIFHPNGDPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XMB4</accession>
    <name>A0A6G0XMB4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_003451</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000037">
        <property type="protein sequence ID" value="KAF0741340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XMB4"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0741340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="66" mass="7168" checksum="6F2473EA77AB4F99" modified="2020-08-12" version="1">MKTDISKSAICPIADSDSVWNCKTISKSKSTLPRDVATRQRTSTILILGRDGDEECDTQKFGSFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XN55</accession>
    <name>A0A6G0XN55_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-deoxy-7-phosphoheptulonate synthase</fullName>
            <ecNumber evidence="4">2.5.1.54</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">3-deoxy-D-arabino-heptulosonate 7-phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">DAHP synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Phospho-2-keto-3-deoxyheptonate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ae201684_003087</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-I DAHP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="4"/>
    <dbReference type="EMBL" id="VJMJ01000034">
        <property type="protein sequence ID" value="KAF0741901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XN55"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011342"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000005">
        <property type="entry name" value="Phospho-2-dehydro-3-deoxyheptonate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006219">
        <property type="entry name" value="DAHP_synth_1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00034">
        <property type="entry name" value="aroFGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009395">
        <property type="entry name" value="PRK12755.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE DAHP SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225:SF12">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE, TYROSINE-INHIBITED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="DAHP synthetase I/KDSA" evidence="13">
        <location>
            <begin position="114"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF0741901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="427" mass="45920" checksum="3C9F0E7CEE6DD3C8" modified="2020-08-12" version="1">MASSNQQSVALGVALAAVTVAWTGTMGLLIGLYMSRNNVADAISIEQNRKSKSRSREVSVTNASDAKIMDKQALVDVRIGGIRALIPPVCLLEEIPRTIQIARTVNKGRQEVNNVLRRVDDRLVVVVGPCSIHDPVAAIEYAKKLRALRDTLEKDLVIVMRVYFEKPRTTVGWKGLINDPDIDGTFNINKGLRIARELLSQINELGLPAGCEFLDTISPQFFCDLVAWGAIGARTTECQLHRELTSGLSMPIGFKNGTGGSLQLAVDAVVSAAHPHSFLGVSSHGLSAIVTTNGNDSCHVILRGGSTGPNYEKEHVEKCAELLKKAHQPENIMIDCSHGNSKKNHRNQPLVAADVGAQVASGDDRIIGLMIESNLVEGAQKLTPGVPLEYGKSITDACISWDDTVAVLEGLAKSVRDRRAAKGAVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XN66</accession>
    <name>A0A6G0XN66_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">oligopeptidase A</fullName>
            <ecNumber evidence="8">3.4.24.70</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_003114</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Hydrolysis of oligopeptides, with broad specificity. Gly or Ala commonly occur as P1 or P1' residues, but more distant residues are also important, as is shown by the fact that Z-Gly-Pro-Gly-|-Gly-Pro-Ala is cleaved, but not Z-(Gly)(5).</text>
            <dbReference type="EC" id="3.4.24.70"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the peptidase M3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.70" evidence="8"/>
    <dbReference type="EMBL" id="VJMJ01000035">
        <property type="protein sequence ID" value="KAF0741742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XN66"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000913"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06456">
        <property type="entry name" value="M3A_DCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034005">
        <property type="entry name" value="M3A_DCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045666">
        <property type="entry name" value="OpdA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF83">
        <property type="entry name" value="LD37516P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19310">
        <property type="entry name" value="TOP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Oligopeptidase A N-terminal" evidence="11">
        <location>
            <begin position="32"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="10">
        <location>
            <begin position="236"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF19310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0741742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="699" mass="79646" checksum="7FF6CFCEBC97172C" modified="2020-08-12" version="1">MDNSVTTILWEDSLPPFQRLDAANISAAVRAAIDDMVLEMNSMEDDLSTPNAELSWELVMDRQEMLADSVDRMWVVLTKLTEVVSTPELQKAKADLESDVAKVLTRRVQSVEICRAMEILRAGPEWSYSSVEQKRILNRAILQARLNGVGLLDDEKMRFNEIQLRLRQLENQFQSNILQAADADALIVHDKSELEGIPSNLLAVMARSAVAAGHTEATAEGGPWKVSADASLYRAVMQNCTNRKFRQRFHKVYVTKCSSGPLDNRPIMQEILDLRHERAQILGFNSYAELSLATRMAPSVLSVTEMINDLRDAAYPVAEAELHQLQEYALAHGQTEPMEPYDVDYWRVELSKETMVLDHEVIKEYFPRAKVLEGMFELASQLFGIRVEPGDESVETWHPDVQFYQIRSMERPGEPVIAYFYMDPFARPGQKRIGSWTQLLVARSKVFGTPEMPIRLPVFSIVCNQIPPADDESPNLMPFDSILQLFRNFGHGLRVALNQAEYSFASNFDGVELEALEMTAVLWQYFCFDRGVIQMISSHYKTGAPLPDNLLESLVAARKYMAATDLLRQMRFAATDTALHHYYDPDSSESIRQIQLQIDERFCVLLPIPGDQQVCSFPHAFDGKAMVAGYYVYKWAEMVTVDAFAMFDESKHEDWKVIGRKFRDTMLANLGIYHPMEAFQMFRGRPPRHEALLHIYGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XN67</accession>
    <name>A0A6G0XN67_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_003100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000034">
        <property type="protein sequence ID" value="KAF0741914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XN67"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018598"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43102:SF2">
        <property type="entry name" value="GAF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43102">
        <property type="entry name" value="SLR1143 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="268"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="124"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0741914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="397" mass="44365" checksum="1DA3411837F62DED" modified="2020-08-12" version="1">MLLKLPIPVPIDFFQCPPMSALDIKKYRGIGVQAAQDLIDFTRLTNGPIDWVLHTHSKAVQMYTARHENIPIFCLLSEIEASLDDIIAIFLKTTTADLRQTNSAFFPNLLDKVRLANVTLPSDDRPNHCLGSSSRRPSEVSSSSTATSTTLSTKTNASLTANELGSKPYDLWILRDAQILTTLTASFVPSLNTQDSSLWRRRRREVIELQHNRPNGQLEGPIADILMTKQALMQYKGMGSTQRVVRSYQLSKLSFLSEDSLVPAHMRSKCTICLKTFGTFQRKTHCRRCGEVLLWLSRCDVWGLLISGIQVRVRICNPCASIHKTTSCLANTSSRVTSSSASRSTSDDRRVDYVAAIPYEGPWPNHAYPPPAVDYDESGIVRVDIRRRGGQAIQSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XNC4</accession>
    <name>A0A6G0XNC4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">THH1/TOM1/TOM3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_002919</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000032">
        <property type="protein sequence ID" value="KAF0741978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XNC4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017408"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="262"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0741978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="39147" checksum="D7D984BE8DEC9E10" modified="2020-08-12" version="1">MANATVVPPVIHLEFRYKEIDTILAVGYAIASVVSLWTLISHMNSTTKDIATAGFYMLLCLASLVRAVWFSTPYSVHVSGYVPQRLHIFDEGWIMMCLSEVAEMLGTLLLYAIFILMVVFWADLLHRAFDPHGYSTPRPMQVFLSLLFFLVIFMSTGFALFAFDRIDSLLLLMYNDFAVALLSGITCLFVAIYSCRIRTVLIAFLEVSQIETTDRIQTVTRTGVLCGFFLLVNGCLETYMGLQMYHLVEADDSSSFLPQDSVSWWLLIMAKHLVEIFILYGLLYILWGSTGGSEATDSKSQSDLRRHYESIPDVTSSPSDAIARRSSSTRRFLEAPHHGSNHHHNHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XPL0</accession>
    <name>A0A6G0XPL0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_002677</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000029">
        <property type="protein sequence ID" value="KAF0742273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XPL0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009401"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050672">
        <property type="entry name" value="FBXO45-Fsn/SPSB_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245">
        <property type="entry name" value="SPRY DOMAIN CONTAINING SOCS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245:SF5">
        <property type="entry name" value="SPRY DOMAIN-CONTAINING SOCS BOX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="2">
        <location>
            <begin position="245"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0742273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="427" mass="48291" checksum="6C6B9FC2667B9991" modified="2020-08-12" version="1">MIVSPDIDPEADDRSDETHDPELDDENAVVQELDSLLYRASTEASPAKSFTSSSSSTHDEVPLDEFQTTEPYKESLTTAEPAPTAEAQEEPQRIALLSWRRPVLDDNDENVERVWHRVDMTHKSDTSPSDTEGFRDGTIDDVETIVYELQNECERSQHQVRTLYTRLHNGLPLDAADFLKDQLYALAQQSERLEHHSRSLRRILTLQENSKAEEHTVIPKKRGRPKSEPNRAPKRGKAPPLEEKPLEEVLAEISGEVVEPPIQQRLFWDPERVGQYASVSNNGMTMKTRGPAWNVAMGNITVDCFAVKIGFPKTKYRNAIAIGFIKEPSFWEVQHESSAVFVFNYSGWYMNVRKGSLCSLQGHDDAPFVHPLKHGDILTVILDKTSKTISFLQNDTHLGVAFKDIEDEALFPAIISYDANVEMTFVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XQ95</accession>
    <name>A0A6G0XQ95_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aminopeptidase</fullName>
            <ecNumber evidence="11">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ae201684_002476</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9 11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="11"/>
    <dbReference type="EMBL" id="VJMJ01000026">
        <property type="protein sequence ID" value="KAF0742574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XQ95"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012220"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000001">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000002">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF174">
        <property type="entry name" value="PUROMYCIN-SENSITIVE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 11" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="14">
        <location>
            <begin position="14"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="12">
        <location>
            <begin position="238"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="13">
        <location>
            <begin position="548"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF0742574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="883" mass="99427" checksum="2B6E54DE7EE12212" modified="2020-08-12" version="1">MPHEFARLPTSVKPLKYKVNYDVIDLVRFRFEGREEIAIAVQSATNMITCHAIELWVYNVKVVLEDGSIVASLETRFIEEDQTVTFVLERELPQGSNAMLHLTFKGLLNNDLRGFYRSEYEYEGQKRFMAASQFQACDARRAFVCWDEPAIKATFEISMTTPANLTAISNMHVLSTSVVAGSALLPAEKVWHFAESPVMSTYLVALVVGEFDCVSDYTDEGVLVNIYCPLGKADQGKFALSVATKSLSFFTKAFGLQYPLKKLDNLAIPDFAAGAMENWGCILYREAALLIEPGQTSKAKKTQVALTVAHELAHQWFGNLVTMEWWTGLWLNEGFAHFMEYDAVDHIFPEWKMWENFVQEVTLDSALREDALLSSHMIEVEVNHPDEADEIFDAISYCKGSSVIRMICEYLGKDVFYKGIQIYLKRFSYGNAVTVDLWNALEEASSLPLTTMMNTWTKQTGFPVVTLSHLVNGQFALSQTRFLSDPTIKDPDNSMWGIALTGIIAHGSTPTSAHLGIWSARDQPSRNAAFEIHAPPSVVSQLPSSAQWIKLNASQQGFFIDNYDSEGWRRLQAPCKDLILSDVDRLCLVDNSFVLTRAGKLTLTDALDFSRAFAADPTYIIWQSLSTHLGFYSELFSRESFLPKLQSYIRGFFGPQLQRLTWFAQDSDIETTPYFRRELIRMLGGAKDPAVVAEAITQFQSIVTNPSASKIASDLRAAVFRIAGTQLQEQAYDSLRSLHETTNLPEVKNDCLVGLGAVKSKWNETLEWAIAGNVRSQDIRYAFAGVVNASLDGADFAWNFIQTHWDVLNEKYIPTLVGTLVCSAVNKFYTEVKANEVAVFFQDKKTSAFKRRLDNALENVRTRSICFQRDVKHMETWLNDHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XR48</accession>
    <name>A0A6G0XR48_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_002338</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000024">
        <property type="protein sequence ID" value="KAF0742795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XR48"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006983"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF50">
        <property type="entry name" value="BIFUNCTIONAL ALBAFLAVENONE MONOOXYGENASE_TERPENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0742795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="520" mass="57566" checksum="81B73A6C36B5D4D7" modified="2020-08-12" version="1">MNWMLSFDEVAFVHLQRGASIPSMAISYEMAATSVGVIAVCALYKWLQVKPFISTLKISRHLHQPLLGILSYFSTIEGLGVVMFDEADDDGMVQFFLAGMPCVSVLKAQHIRQILLASSFRARNPLFDSANEAFLGKNALPLLMGRPWKIHRQLIAKAFGWQNLVAMVPAIHSIAILFADRLIKESTADIVPLVKLATLDAIGACAFGQSFDALDDPSNPIVDAFTFLLDDLNRRTHEDVLNPANMFHWLPTDNNKKFHAKTKILREAIDALVASRLSKTSASHHDLLQFMIDAATEEESGVTPQSFSDNLLTFLFAGFDTTSITLAYAFYLLAIHPDVQDKALAEVRQVVGSNDITYEMVQNLPFCTAIIMESLRLFPPAFLTVRTLESNMTIGRHDVPAGTTVMLPIYWIHRYAPNWGPDAEAFRPERHLEDDDGVNLGAKEKGFRMLAFSGGPRNCVGMRFAMLEAVIVLATLLSKCEFKRPDDAPPVRVALAGIVQKPKDGIWLNVTPRGKTAHAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XSQ4</accession>
    <name>A0A6G0XSQ4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_001910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000017">
        <property type="protein sequence ID" value="KAF0743439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XSQ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012242"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0743439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="416" mass="46921" checksum="1BD493C612FB173F" modified="2020-08-12" version="1">MPPPRVFGQSTSRALSDDVLHKIALFIEHPDDCFSFLEAVRAAGTLPGHLEHLWQLGHVKNHSDLWPALRLSADDEHLSEASHQVLKAVAKYYTVVHVHGFPISMIDTLQFDSFDSEAEWHVEMTAEMADSAWNEWLNVRITSLTMDMLHWKGRTIQTALNSLARFHHLTTLNGSALLTALELECFSPDLTPSIARNLTLWFERQPVRVFKFPGWRTGRIDMALQRVVDQVVFNCPTIDKLTCSGLYLQSVDLTSLAFPMPSFELISFLVRTEELSTAFASHLVGSGVRHLAIVIKHRITSVEISGCLLDHSAWRALTKCLPQYRQLKTLKLVQVYMTSERAAWIAAAMHENHSIQHLDVRDNVMNVASLNNLIQACTHPTRSVRMLSLEFQGCGVSSDEYVPLRAFADDEIASPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XT12</accession>
    <name>A0A6G0XT12_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_001717</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000013">
        <property type="protein sequence ID" value="KAF0743571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XT12"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012660"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0743571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="379" mass="43685" checksum="AEF31B4060D341B5" modified="2020-08-12" version="1">MRRNNKNIHADLALREVHGRPRNVKMKRRITWNFQDVAQVEDQAVLMGFSNNGRYLLFYRPWGQRAQVYWRGFNPCGKSLVSRDKVMQINVGPTRTTLSQHEYELDDDMELCIWESHDEKLVIATLSTRGQTSCHITIAPGPLLCQKAEQSTALLFSLSLTTPVHQSWFIVPATNQLVFHVGSSLLLMSMTLNGATEVFRPLTTAWYHPSEFPVEIVQESSQPHVLNKLICECKHQTTFDIETFLRSLLDTYAAFRPFHLHDYDLRYLCVSESSWIYMCGALDLERIDVPTWRRVGVFFAWNALDGAFKVIRLLTRPHNVTLTSAIEELVRHCRGVLSRHVSIQPQPFTMWSNHGVLRGASLNRIDNPIFPYSIVRSQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XT48</accession>
    <name>A0A6G0XT48_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Clp ATPase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_001435</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ClpX chaperone family. HslU subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XT48"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002675"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009376">
        <property type="term" value="C:HslUV protease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050052">
        <property type="entry name" value="ATP-dep_Clp_protease_ClpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004491">
        <property type="entry name" value="HslU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00390">
        <property type="entry name" value="hslU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003544">
        <property type="entry name" value="PRK05201.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102:SF3">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE ATPASE SUBUNIT HSLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="86"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Clp ATPase C-terminal" evidence="6">
        <location>
            <begin position="373"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0743784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="481" mass="53801" checksum="4D030F23F24E46A6" modified="2020-08-12" version="1">MLSLCRLRSSRRLFPAVARRCFSDFTIVESPVVPFEGSLELTPEQVVYQLDQHIIGQTDAKKAVAIALRNRWRRRQIEGPMRAEISPMNILMSGPTGSGKTEIARRLAKMTASPFVKVEATKFTEIGVFGANAESMVKDLVEVAIEMEREAAQKKNAAAARERAIDRLVTALTQRSDSVSEALRRRLREEIETGAADDRLVTVTIKPVVAKPSRSRLNEDMAMEIPPELEQMMKQVSQVLGMRQDKKDKAKGQTMTVKEALPKLEAEEAAKFVDEEDIVRLAIENVQNNGIIFLDEIDKLANDDRHRSFRKGEGVQKELLALTEGCAVNTRHGIVYTDHILFIASGAFHKSSPSDLMPELQGRLPIRVNLSPLTEKDFVRILTETQFNLLDQVRALMQTEGVQVVFTADAVEEIASVSAKVNSQTDNIGARRLATVVSKITEHVSFHAPSMKNSSVTIDKEYVQQHLKDILKQTDLTKYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XT87</accession>
    <name>A0A6G0XT87_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_001412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XT87"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0743758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="120" mass="13719" checksum="52632206036FB1A4" modified="2020-08-12" version="1">MLQQRKSSFEVRLPKIETHHGRWNTGRLDTLKAMEGLFSRQRRSPMSTLSRSIAASDRREGIPAGRPSFGQDVKDALNEHVDLASAVNGDSTELTWNALQTARKNYMHEEERAEESIRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XTG8</accession>
    <name>A0A6G0XTG8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BAH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_001391</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XTG8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005932"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000949">
        <property type="entry name" value="ELM2_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82061">
        <property type="entry name" value="BAH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51156">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAH" evidence="3">
        <location>
            <begin position="21"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="ELM2" evidence="4">
        <location>
            <begin position="166"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="321"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="330"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="350"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0743736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="363" mass="40483" checksum="AF1AEA6C55EEB412" modified="2020-08-12" version="1">MPRYITIPPRAEREPPLPGQVPYAVGDFVEVAGRLGNEIVLYVVEIISLWTTPYVGFTGQYYYKPRDLGEKIMAQFPSSVNPNEITSPEAAEALKCEDNEIFQSTYSGDNHVAAIVRKCNVVTASQFHHQLVHNPDDVSTYLCRYAFHAWKFPSPFSKLETEEDRVSVRVGDDCQAVVPPFVEPMTTVKEEKTAASPTKELAIRRWQSSKNEEGDAVETFLQVVKCLQIAVGNIVYAWHEKAREQILSVLEEHKGNHSFRVVYLDGSGSIVVDASFVRGLVSQDEALMLLHEADYNYRIATEQVTRLISTRSAAAVKFARDTHSDDGNASDSSVASTSSSSPRTFKRQCKQQAQSSGKATRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XUF2</accession>
    <name>A0A6G0XUF2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_001666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0744033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XUF2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021667"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="1">
        <location>
            <begin position="147"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0744033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="215" mass="24594" checksum="5D65EB63A115EC6C" modified="2020-08-12" version="1">MSVFVHPTTKEVYVIDWLDDVRQRHMAELAVALNELHRDVLAKSDKLRKQARKRRDEKASVKLTNFSVGDFVLVGAVVKQSTKLSLVWRGPEQVTRVVTDYVMETQQLVPPYGVSLHHACRMKMYPEAGREVTEDLLEHIAFGDGGFHVERLDGVRVQDGRYEVLVKWLGLEDEESSWEPAQNLLDDISVVFVKWCESHRHDEAVSDIMDSLGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XW59</accession>
    <name>A0A6G0XW59_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_001091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XW59"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001601"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="378"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="414"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0744625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="441" mass="49723" checksum="4300F2F344C83069" modified="2020-08-12" version="1">MVQVVPEGDERRLACTTPTPLASDTILARRTSKQIFWNRLSAFYDVCCWCLTLNLVATQVINAFMDESMMDTTLVYGSRPFESTIEYIPGNNDDPYIDRAMACVLVGRVYKAVTLAQALNGVAVIKQLANITYDSYTVMVRSDPQTTMKDTYAYYNPICSTIALTINGIRHACTDQGYLPVKDSLRINVGTDATHTTELTNALPVLIIPYWDNPAAARYGIPGEDGVFCTVMLYNQYIRPGGIYQVVAINRSDFDSKTRLWLNEPHGTWRNGWYTFPDGLTRYYSHMQNDLRSKDQPKGLGVEAVVYDGLTESIVDCTSNPTFCQSQQLMIWESVVLHKATALWAECVCIQDKDRNGLMWYSVQNQDTITFRGGLRAVVANLSIFGLLLRWSIALLAAWRGYLYYTSDWHRCGIGILACSDTFVWLPLLLGSNIKLIFLCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XXB1</accession>
    <name>A0A6G0XXB1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_000231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XXB1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004973"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052061">
        <property type="entry name" value="PTE-AB_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260:SF1">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="1">
        <location>
            <begin position="148"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0745197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="236" mass="26020" checksum="0220B420CB02131B" modified="2020-08-12" version="1">MIARRTLSKLLRPVAQTRSFGHAFTARQNKPMSFALSGLLGVGILGCTILQDDSSLASNDTLNAHLKTASLAKVNIPSKIAALAKDPKFVNVGEEFFDTVPISDVEKNYVHSLHREGKIEAFQVYGDVDRTKTTTLIHFGEELCGHKGIVHGGCIATVFDELFGWTMYWTSDKVGFTANLSVNYRKPLLAKTSGIVHVEIDKLEGRKLYLKARLEDNDGVHYADATALFILPRDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XXB6</accession>
    <name>A0A6G0XXB6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_000268</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XXB6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019650"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021910">
        <property type="entry name" value="NGX6/PGAP6/MYMK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36561">
        <property type="entry name" value="HAEMOLYSIN-III RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36561:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12036">
        <property type="entry name" value="DUF3522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0745236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="218" mass="24534" checksum="E4D8F1F894BF137A" modified="2020-08-12" version="1">MWPSISVVQLCLTALADLSMLPAISIMVQNRRHFELFVASLHIIVSLIHNISQSFDVSVFLTIDEWHNMSDVLWIAYFLLLCIHLLGHKDVQVTMILRYIAFALAWMAKTKDTWSSNTYSTILVATAMTFVAVGRQIFKKELLPIQLPTLGYAGGAGAMAMLLFAAPRFIHMSETTFFVLVVPSFHMALGTMFYFGWKSVAPATPSKIWDDSLTVHFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XY39</accession>
    <name>A0A6G0XY39_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Calcium uniporter protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ae201684_000496</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCU (TC 1.A.77) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XY39"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002340"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990246">
        <property type="term" value="C:uniplex complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015292">
        <property type="term" value="F:uniporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036444">
        <property type="term" value="P:calcium import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051560">
        <property type="term" value="P:mitochondrial calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006769">
        <property type="entry name" value="MCU_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039055">
        <property type="entry name" value="MCU_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13462">
        <property type="entry name" value="CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13462:SF10">
        <property type="entry name" value="CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04678">
        <property type="entry name" value="MCU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="340"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium uniporter protein C-terminal" evidence="16">
        <location>
            <begin position="216"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF0745482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="427" mass="47610" checksum="9A28E88F40943C16" modified="2020-08-12" version="1">MIAAKLLRRVAVCPSAPDLKVVGMAQRMKWMHVAPFTSSLPRLAVGTTSSFGAGSGSAGKPLELKYLEANGSLALALPLTGDPQSEIGLGMKLFSLLPTTSVASFVAQVQLEDSTAKDVQIRTQKGVPVAPETTFSTLMADDFQIVLNDKVLRVAAPVFTGDAYTSLPQDGGLDIRAIAHKAAIIKLRETIANHPKWKIDIAEFKKLAADHGIPSKQANQVLHAFHQVGLVFHFSHAADEELRTAVFLKPRNILDGYFDSLGLVPPSTQRYLEKRQQLEADLAAIMPEHDALLNLQKQLDDTAHKRTRIFTYLSSTGLIGMGSLYAWLTFIEYSWDIMEPVTYFTGFGVSIMAYFWWTMTSSEYEYENVYDFIFQRYRQKLHTKWHFDPAKLEKLQAKVADIHRDIASISTKITKPTCLQAEFLKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W3U6</accession>
    <name>A0A6G0W3U6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_018992</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000371">
        <property type="protein sequence ID" value="KAF0721677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W3U6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018671"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="325"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="335"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0721677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="379" mass="42328" checksum="24D49E94D4557DA9" modified="2020-08-12" version="1">MDAPPSTSTIDVSHFSPEQQATLTELLRLIPENIVRGLFSGVNPQDQIIVIESFRLHGEATAQSATHAAAQRTQEEEALLYEADLLKATAKITGLEESNRNLASHTRRSESPSSGIDDIFIDSRVSRDRPLKLEVSKYGGAANEHLFRWVSEVKLALGAQLVTNEMLRVAFALSNLQGRARDWAYNLHMLDDEAFPSFDSLVDQLKEQYVHSNVETRFRAKFYQAKQGKGTTQEFVNDLRSILGSFENSYKIDEIGRVTVFMHGLNQGPARDELFRLQSQGFNEAINIALNTEHSRGLARVSAKSSDVSSDMEISRMEAASGEERRCFNCGQSGHFARKCPQPPQARKNPNYFSHRSPGGAYRGRGRGYGHHQGKDKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W4V0</accession>
    <name>A0A6G0W4V0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RxLR effector protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_018705</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000349">
        <property type="protein sequence ID" value="KAF0722068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W4V0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018223"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026351996" description="RxLR effector protein" evidence="3">
        <location>
            <begin position="17"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0722068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="176" mass="17667" checksum="7CF946190B7BFFAC" modified="2020-08-12" version="1">MKIAVFAAAGAALAAAAHHTNHTSTTNATNATNATALHSVVFPALNATKNATNSTNSTNSTKDAINFAKVHDRAPTQSTFLNLDKGDIVTIGAGFVGSMLVVAGAAVAINKRGKAAAANADKDASVLAEDAVEEIEAAENAGEAAKEDEAAPPASPADKEEDIQDVSTDSPSVVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W629</accession>
    <name>A0A6G0W629_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_018795</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000356">
        <property type="protein sequence ID" value="KAF0721935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W629"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021695"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05483">
        <property type="entry name" value="retropepsin_like_bacteria"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034122">
        <property type="entry name" value="Retropepsin-like_bacterial"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13975">
        <property type="entry name" value="gag-asp_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0721935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="635" mass="70280" checksum="BC6FE51072F1417C" modified="2020-08-12" version="1">MALGGYEERLRASVRFLASKLASAATPPVISEESDTNSLSTPTPVIWNISSPSPTIAPQVFFANEDSATMPQQLNLLAGERLGFWRTSEVDHEAHCQAFLDAKILNEPAVVLADTGANMSVLHTRFAERLCLRVDTSTTTGIDGFGNGSATTAGTVPIKLTIGDGLTYLFTIALCDFGPVGFHAILGMDFLEKAGMIIDTVKREIQLPDDNWIPLVLQPIKYRRGRVDTVKTPRQIQLQPGDSVCIKLPSPRPGLTNAPEFWVQRGARWVTTAIVDDSGTPRSYRVTNVGNSLLVLPPHSVVGAISAPGDRPNDHTMVRTNSLRYKEWKAAAYEGSYSTRYQRMRDQVMAGDCLETPYTDRPPRAPPEALLTQSGIRRLAQIGADTRPGDVDTRKDFTGRDGHEAVLVDDTTKQESNFSYFVTEHHQELPPPSIFTLQAPSPDLDQKTLPLEVVIREEVDLTSEEMESQLALIPEIPPQVPFDMDQLDYGEVGQPEEERQQMRKVLDKYKAYFIRSGNGLPPPARGTVCDIDVGSAKPIAHRPRRVRPEHLQKLFELLRGLLSYGLITFSNSQWASPIVIVPWTPCYQASTRCSGSYPLTMPVDSGWCVPPNERDSSALSFARWDTLSGRVWVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W636</accession>
    <name>A0A6G0W636_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_018319</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000330">
        <property type="protein sequence ID" value="KAF0722586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W636"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002172"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000059">
        <property type="entry name" value="N-ethylmaleimide reductase, FMN-linked"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="5">
        <location>
            <begin position="4"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="114"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0722586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="381" mass="41784" checksum="DC63B961C12641D7" modified="2020-08-12" version="1">MTTLFEPLQVGAITLRHRVVMAPLTRTRAVANENGVESVPTPIMAMYYGQRASEGGLIVSEATPVCPEGRPSAHVPCIYDPLHVERWRAVTDAVHAKDGFIFMQLWHVGASSHSLFDPKRRPPPSSASYKLDAPEINTPEGPKPREVTRMLTTEEIPELIQQFVDGAKRAIEAGFDGVEIHGANGYILDQFINDNINNQRTDQYGGSVENRVRLPVEVATAVAAAIGADRTGIRFSPFGSFQGMKDSDPVNTWSTLLKQLNPLKLAYVHLVEPRIAGGWDSSNAPDPEQINLKPFRDAYDGVLIVAGGHTAESAAAVVKEGRGDAVAFGRYFISNPDLPARVKHGHPFTPYNRSTFYTATEVGYTDYKSWEEQQQEGEATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W6N2</accession>
    <name>A0A6G0W6N2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ALA-interacting subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_018894</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CDC50/LEM3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000364">
        <property type="protein sequence ID" value="KAF0721786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W6N2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021240"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005045">
        <property type="entry name" value="CDC50/LEM3_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926:SF0">
        <property type="entry name" value="CDC50, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03381">
        <property type="entry name" value="CDC50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015840">
        <property type="entry name" value="DUF284_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0721786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="397" mass="44928" checksum="B6CB0F253F612EAB" modified="2020-08-12" version="1">MPSESPPASRKPEDTPFKQQRVPSWQPIFSPMWVISAFFFIGIVFLPIGIGLYAESRKPIDYRVQYDGIDWVGSNQNSDNTKLTQLPGASCYLENKTYGHTFNLSQHGCVVSFTLDQDVKGPILVFYEIGNFSQNYKHYAKSRSSDQLRGKDNPDISDCQATFTDVDEAVKFNSSAAPSSYQLNPCGLMANTLFNDIFWMHSIVSPDGKYYNQTDLYDGVDVLNLMDQSDLSWNSDKNKFKNYANLDSSQMYLWENPKYGWIIPSRVGQQPIINRTAWTKPTTTYGVESDRFKIWMREAGLPYFRKLYGRINMDFPKGTTISFLISSNFPIADIHGRKSIAIATKTWLGGQNPGLAIGYIAIGGICLILSFLFFGKHKLSPRRLGDANYLVWQGKNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W6P3</accession>
    <name>A0A6G0W6P3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_018189</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000326">
        <property type="protein sequence ID" value="KAF0722709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W6P3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015685"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="3">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0722709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="29189" checksum="C01A1FD7FAFF78AA" modified="2020-08-12" version="1">MLYQTVDDVIAAKLKAPRDVNRPVDIVDLMLDENAHAEHKVTAEEARTHVMTFMLAGHETTSTTLSWVFTLFAQHPHIEAMAREEARAATANGGTIGWKMLGELKYITACIQEALRLYPTISRLASRVADKDDYLPTTEGKPVFVPKGTVIAITPAAMHRNPKYWNHPEVYLPERFIEGTDAFLADKALRNGQGNTYYYMPFSAGAKNCIGMRFAMAELQVVVATLLLRYSFRLTEQANVNPTLVGVSIKPVHLDMTVHSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W6Q0</accession>
    <name>A0A6G0W6Q0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_018402</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000333">
        <property type="protein sequence ID" value="KAF0722459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W6Q0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016435"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0722459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="607" mass="67645" checksum="9C2DC72C82BC7EC9" modified="2020-08-12" version="1">MSGPRHATAGLVLRRTRSQEFEYASGVTLPLAAPSVAPPFAAYPPDITSVQQLGQQVQQAVEAQSTRLDSVQQVVGAQQEYTYEQLMALHQKQQEQYAQQMQMNDRLVAQLADQRNHQQTLVEQLMAQNKVTEAHEQGLHMAAEFSVKHAQQLEEMRRRTSARWHAFSAAPPEVPKAPTFNGSTKVQMRRFMDQYEAYSREISLANAQRPGGAQIHQVPLSACIDPLAVERIAFWEMGKPSRELTEDDWRMYFLSAKDCGPVDMTKLDSAMTKLKMDVSIQSAESRVSKLVSDFEAVLVRLSMEGFAEAEPKLTVEYLVAVIQPPIVRGRVKELLKLHENRGLKKDARVFKTWLSEYMLRYGEFEPLFSAQKPAGEKSQNAKPAKGDKKAKMVAVVNVDKIPVSNFLQDKRICFKCLSPEYHVFKCPRVVEGEAKLLMDRARAVWKEMAAKAPNNEAPKAKAVTVVERQSPVEGNVTSAVACAARVVCLASDVVALDASFDSGADQSVVPPTTLKKLTKHGREVPVVKLRTPVSVKGFNGPTYSVIEEAVLDLIFNTEAGPLLLRNVKCWVSGYDLPAGVGEILLSRAIMYKLGYDPRSMLREIRYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W720</accession>
    <name>A0A6G0W720_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NadR/Ttd14 AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_018866</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000361">
        <property type="protein sequence ID" value="KAF0721879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W720"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015415"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070300">
        <property type="term" value="F:phosphatidic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038727">
        <property type="entry name" value="NadR/Ttd14_AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053227">
        <property type="entry name" value="TRPL-trafficking_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34932">
        <property type="entry name" value="TRPL TRANSLOCATION DEFECT PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34932:SF1">
        <property type="entry name" value="TRPL TRANSLOCATION DEFECT PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13521">
        <property type="entry name" value="AAA_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NadR/Ttd14 AAA" evidence="2">
        <location>
            <begin position="57"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0721879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="394" mass="44426" checksum="FB626EF247CB67DB" modified="2020-08-12" version="1">MEIGPRAFPPVELTNRPSTTNMSDNESAPTRPRAGTNSVPLMHSLKPGADSAIPIYKFVLTGGPCAGKTTSLDRLSSYFRERGFRVYMVPEASTLLQTGGAYVMDLKASDVLNFQWQILSTQIALEDAFTSLAKDTGCPCVILCDRGAMDGSAYVTAEQWEELKSIHDLDTVTLRDTRYNAVFHLVTAAKGAEAYYSLENNGARSESIEQAIEADDRLCRAWVGHPKFFVFDNSTGFESKMQRLISTAANLTGLPSTVKTAKKYLLRSFPTSWPIHVEEFEVEKVYLSVLPTTDEGTKDYDFVRCRTQYGLPSYGMTTVRYLEDSDEPVHLKRVLSAREYAYAVRHRKDHTRKVIKQRRICFLWHNQSFNIHWDCPRPGVRLGHGRLDPVVPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W7D7</accession>
    <name>A0A6G0W7D7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycine zipper domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_017980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000318">
        <property type="protein sequence ID" value="KAF0723016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W7D7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006777"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026296900" description="Glycine zipper domain-containing protein" evidence="2">
        <location>
            <begin position="16"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0723016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="261" mass="26582" checksum="207DF5DAC503A460" modified="2020-08-12" version="1">MRILLFVAMVASVLGSSHPAVVGRQSAEVRQVNRVLPGRFQKAGLHFGGKTGEIVGGAAGNALGTGASAVIGTVTGGNMGTKAGRSGMGAGLRITGEYVGSVCLAKLCGSVGRVADKFTKSGRQAQAAEKNRKKEQAEALKKPVLYNGGRYQQAKLSRTGSSPALLHKTATWQRKETTNPGGASTSGTKPAINKGKAPKNPGGASTSGTKPAINKGKAPMNAGGASTSGTKPARKGGEAPTHIVKSMRIGQTSPTLRKRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W8X8</accession>
    <name>A0A6G0W8X8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ae201684_018056</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000319">
        <property type="protein sequence ID" value="KAF0722981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W8X8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010223"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010224"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF254">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="476"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="608"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="666"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="699"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="766"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="797"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="14">
        <location>
            <begin position="65"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="14">
        <location>
            <begin position="602"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF0722981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="989" mass="110301" checksum="AE7278C2472AB7FB" modified="2020-08-12" version="1">MASKNAPPTSVQDEESQAKASNDVTTTLPKPPTEASERTEMARTATIRTRLGAFMDNPEKSLPGRIYHNFFLVLIVLNLIGLMLETLDGPNHGSSAPEYAMLPYSKSFVVAEMIFTAIVSLDLIVKFAVSKSVKKHFVSAVTIMDILAAAPLYILVLQSGLVALDNSQVQKKSDDYIKLLRLFRITRVVNMLKHKTGMRVLYITAKDCLAPLSITLFFLVTFVMLFGAILFYAQPCYNVSTCTFTDIFNAGYFVMVTVATVGYGDQMPDISNVIVLVVAIIVMIFGALYLAMPLAIVGIKYELTWAQFAAAEKTKVLAKPPSDPNVILTSELLAPTASRINVYYMELCQAASQLWSASVHFDAVMNSDAVEPRDRTDAATKLITTMCDVLRVHKTLLRSIKGFIPQDVLHPEALRDQRTNSSPSRHASSLKNSIVLRARQALSNSSQPDVDPDDVKSFRHRLYLLMERPHSSRQAVYVNRFFLAMVILSMLLFYAETTPEFQVYGVSSQLCHRAVEAYCSMLGRSVQSDPGCFVHSSPNTTTTTRLAFHCDEAPDLADFSQCFGFAWNYGSNTSTIECRQSFVDVDKVCSLRQCQSGHEPIVDMTNKWIYVEVYFAIVFTAELLVRFFAARHRGVFMRSFGTWIDILAITPFYAETITGLVRGLRPFFTIVPTFPTFLTILPIAKTLRILKLAPLQRLMIPLLFLFLGSVCAGAIFYEVQRGTQCQAHLPCLWWDRDIMKPSLAKPFPVGKRIQIQVDKLTLLTDMLRSTWMSIVTFTTVGYGDMKPRTPFGKILDILAMIFGSCYTAMPLSLIGGQFYACYAQFLKDSRATSPQTTAPVMDAMLHQQKRRRRRYPRAKISTADTPLLSQFVAMRHLLNEAILNTYRLKAMPAKVTPSATASVRSMDSMARSLGMQNPRLSATVKSPDAVLANVLTACSLVQTIVLHFSIVSIQDDAAADDDDMALQDVDDSRTRTDLLELQLPIKPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W946</accession>
    <name>A0A6G0W946_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_017330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000294">
        <property type="protein sequence ID" value="KAF0723835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W946"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0723835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="91" mass="10510" checksum="C17615972E369893" modified="2020-08-12" version="1">MDPREIVRRFQNDMHEENHNIAELSQAFHTNPDQIDDAPDTLAPIIDCHFDQSGNRLSPCWCQHGKPDVEEIQCLIEERTIHDDGCVQSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WAI8</accession>
    <name>A0A6G0WAI8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_017028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000275">
        <property type="protein sequence ID" value="KAF0724248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WAI8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019969"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0724248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="109" mass="11917" checksum="80EF0210368E9C74" modified="2020-08-12" version="1">MRVYMQCMDMSENKFDDAPSVALASYSSTPSCGLTTLVLTHCDIADNEIPGFAKPLCANKAYHILDLIRNLIGAKEVLTIVQPDLTTEGSVVTSKNHDEPETELELFAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WAK3</accession>
    <name>A0A6G0WAK3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_016941</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000273">
        <property type="protein sequence ID" value="KAF0724276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WAK3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021522"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0724276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="116" mass="13559" checksum="58911B09F2D2628B" modified="2020-08-12" version="1">MMADATMQCKYAYKQCMNSRTYKRDGELHRLCDYHRRKANSLQKIYATKRRHERKLERERTVHEQVVDPLPFCIPADGDFSVKDLGIDLSDLICLFDDASTAFDTITIVSMHKVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WAV1</accession>
    <name>A0A6G0WAV1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_017216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000287">
        <property type="protein sequence ID" value="KAF0724016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WAV1"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0724016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="109" mass="11287" checksum="509A5745ACD125AD" modified="2020-08-12" version="1">MEYRQSSADLVGLYFNTAGTNCPSVVRLLGFSCLTAPVALNTASSMLKSNRARRGWRAGATTWSGGTCRLGGDGELGLGAVVGSVGAVVAGVVVGAARQVRREVRLVWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WCN3</accession>
    <name>A0A6G0WCN3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_016435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000253">
        <property type="protein sequence ID" value="KAF0725037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WCN3"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0725037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="220" mass="25258" checksum="AB5ACC6D0C590AA2" modified="2020-08-12" version="1">MDQMGCTGCNRYIHLKSIFQRNNKDKKKNIRCFPHCCPARGGHKNTGFCGSSVFVTTDIPCDAAICRYESDTIDESRAIALGDVYDRSFIDSAGDYPAQRMVTEDGVIRFVVNPDVNKKGWSYPYDTRIEKNRKHRLSVYFMRHTHGNQTTCVSSVHSAWFTMRSTRMPKRMAELRAIETKHGASPVLWKSHLRRRLPISPSGRAATDKWAVFNPTWHIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WCY0</accession>
    <name>A0A6G0WCY0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_017101</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000278">
        <property type="protein sequence ID" value="KAF0724203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WCY0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017066"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37558">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37558:SF1">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0724203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="106" mass="12098" checksum="B3058A97F2DD06C4" modified="2020-08-12" version="1">MDVALLREVVRVAPYDGEYVTLTIRWKSIASKLSSYFETDIPHRSARDHYETLLESFKATDKAQRLWGTESNEEVAELVDLLQDLADRSEAAAEAKRVKKEKAKTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WE16</accession>
    <name>A0A6G0WE16_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_015911</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000237">
        <property type="protein sequence ID" value="KAF0725578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WE16"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021168"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004348">
        <property type="term" value="F:glucosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006680">
        <property type="term" value="P:glucosylceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000126">
        <property type="entry name" value="Glucosylceramidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033452">
        <property type="entry name" value="GH30_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001139">
        <property type="entry name" value="Glyco_hydro_30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033453">
        <property type="entry name" value="Glyco_hydro_30_TIM-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069">
        <property type="entry name" value="GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069:SF23">
        <property type="entry name" value="LYSOSOMAL ACID GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02055">
        <property type="entry name" value="Glyco_hydro_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17189">
        <property type="entry name" value="Glyco_hydro_30C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00843">
        <property type="entry name" value="GLHYDRLASE30"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="5">
        <location>
            <begin position="524"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0725578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="676" mass="74777" checksum="7228D69C47E02862" modified="2020-08-12" version="1">MDGALKNSRVAMGAQYGSVEAPRHQHDVKEETPASRLTNSKLLLAVGATTMIVAGFVATSTTQAPTVQLEKSDISNVAINAPTTVHVVESSYLKGKSSLFHKSSTIKVSKSKKKPSSVIYVDDKQVFQEVLGFGGAFTEASALNLLKLPLDKQEEILHLYFDKKTGAGYTIGRVPMGSSDYSPKSYSFDEVVGDVKLEKFDTNVTHDTETMIPLIRRALKLRPDIRLFLSPWSPPAWMKLPNSHGEYSMTGSAWPNGLNSKYQEAWALYFSKFITAYKNHGVNFWGLTPQNEPMFAAPWDACLYTADFEASFVGDYLGPVIQRDHPGVKILVFDHNRDYVDKWAQAAYTKASKYVDGVAFHWYNNDGRELDGALYYNHLNDTHHLDTSKLLLATEACNCPGVATGNDAWFRAQRYGHDIISDFNNYANGWVDWNLVLDHTGGPNHLNNKCDAPVILNPEGTDYTLQPLYYFIKHFSAFVPPGSRRIATDVQVKYTKPGQHNLFTKYPAAAHFCDGSARQVISRTSDNKLQVHDSDYCIDVVHETFGDKIELVKCIYTSNTYDFTADGQIKLGGKCLSVAHGSLANGATITLDACNGASYQQWTVSASVVTNHANDFCLTAGYAFAQAVAFKTPSNRTVVVVQNENTEDAKFTLNTGDGVVDTVVPQGAIRTFYWDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WE18</accession>
    <name>A0A6G0WE18_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_016703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000266">
        <property type="protein sequence ID" value="KAF0724637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WE18"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004658"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0724637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="119" mass="13439" checksum="B7DB6E90E4E6F471" modified="2020-08-12" version="1">MSRRLSSQGNPNTRTMSQGVAMLANLEEQRVQRRARYATVLRDEPDDDPDSSSPVYDGFLETQGPEAIHSMTNFSPAEFSILWAELRTFLARNWNTSSGRKSAVTARDMLFMTLATLKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WEH8</accession>
    <name>A0A6G0WEH8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_016179</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000243">
        <property type="protein sequence ID" value="KAF0725408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WEH8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016588"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0725408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="240" mass="27689" checksum="B4AAA94D023F41B6" modified="2020-08-12" version="1">MGLNGVEWYVPLPARPYLPPAVFLPPLVDSKPSIRFVIALRCIDDGIFTYFVECVHINNDGGGGGVFSFARYLHLTAKLARHLLDSLRASPEHHELAHLHIPHPYQVWLVGRKRAAVLVLELLRYAFDTPRILADPILHDCLDLKLMERQTLLELAFQMHVSRQRLAQVRHKAMRQMRTVVHAMHIHDWEYASMAARLMELRHMYDCSQPLRLPLVIFDHDMASLARIPHLAAAKEPRNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WEN5</accession>
    <name>A0A6G0WEN5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histone deacetylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_015811</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000232">
        <property type="protein sequence ID" value="KAF0725849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WEN5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019412"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004407">
        <property type="term" value="F:histone deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11599">
        <property type="entry name" value="HDAC_classII_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF26">
        <property type="entry name" value="HISTONE DEACETYLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="2">
        <location>
            <begin position="331"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="717"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0725849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="763" mass="85176" checksum="2A08DA99C923D59E" modified="2020-08-12" version="1">MVNAAADELEANPVESNDQDNNADHDDEASNASSFHEFWLHDLIELGHIDALKAGLEEDEDVFQSCLTETDDMGCTPLHTALLYPNEEILSFLWSFGPQALALDTYCNGTPLLHLVLRMTTFSVHRDVCLTFLERLLATETFMESALQSKDDVGNSIFHIAAMANVTTLFAKLDPSRDMLEGRNRMGDRPLHVAVKFRSVDVIRTLVHDHHVDILAPTSFGLSALHLAAASIDAETLLPLLDADWKQCTMKNGLDQTPLDVYTASQGQSMDGKNGTCFLYHPDAMEHLPMAMHVRGKDEPPADNLERMRSLVTPGLGVLRTLEFEQLQVRWEHEIPRADIGDVLRVHEMSYFSKLQTLCGRIPDDMSADDLAMYCLDPDTALSKNSLDAAMRAAGNVCAAVDKVVRGDARNAFCIVRPPGHHAGPVGKVTCEHDRIGSHGFCLLNNVAIGAAYARSHYKAQGINRIAILDFDVHHGNGTEDCLRHLVPRVEEIRFETPYTSGTQVIHKYKPWRNDHDADDVYFCSVHGYGMKDPKGEHPPGMYAGAWFYPGSGETNIPLTKEQENDAEDGDKSPTSKIINIGLPYQRGQLARQEWRRVFRNIVLPQVMAFKPDLIFLSAGFDGHKNESVNWGYIGLMEHDYEWLTQSVVQVANSCCNGRVISVLEGGYNFHGRVASCFSRSVAAHARGLVHGARFRHEWSDAAMAYETQCEESMIQDAAQKKAKRQSMEESDGLEKRESKRQRKVVDYVALAAELQKENTEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WET8</accession>
    <name>A0A6G0WET8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_016547</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Integrator subunit 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000258">
        <property type="protein sequence ID" value="KAF0724871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WET8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006752"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034472">
        <property type="term" value="P:snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026236">
        <property type="entry name" value="Int2_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029321">
        <property type="entry name" value="INTS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28608">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28608:SF1">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14750">
        <property type="entry name" value="INTS2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02105">
        <property type="entry name" value="INTSUBUNIT2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0724871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1054" mass="116657" checksum="F1E85571115322D5" modified="2020-08-12" version="1">MATATVASSLHELLTSQTRQERAEGQNSKSISPYIPTLTRLLHAYPTGTSRTAVVEIQDLLFDQPDATLGKEYAMAFRQVSLDDIMQKGDLYDPSVFPDTGNLVTRIEWVVETLHAAISTQRETGKLPQVQWGANSSHVMELQCIICHALARDWLPVAALVPVLLETSMAATLLVTIVQNDPSASSTVVESVLAYAKKSDMDQFDKTHDVLFALGGISLSTAHLIRSYCIDQSSDSSFAAAAAIALTLEYINDLPLFFNRIMQGSKHAALWSVISESHQDPTNSFRVRCNALVERVRSHFQSLLEQPLPSQSSKVSLVVLLRAYCGLMGRGSVVLTDKETQLVFQAISNACRSSAQSSHGVERFVHVSVAAIVLICLGKLDAKAQPVVAQEARRLLQQLFEMDPTRSGVVLLMLSLLLYTKPTMVADLLRSLVDSMLVVAVDRLPLFGEHVVKLDFPEPVLVHRLLAMTPPQDINATSSSLTHEFTLRVAYSLLCERSYVRHKVNPTEWVLSLVFHATLPVHPILPNLMVELVENHVAAYDMSMQKSAMPALRPTLVHDTIAAVMTKKDANTWTRAVLLLVYVLHFNRRHVKDKSSRKYDVFDLPVATLFRTVTQSSHVGAAYEFVFPVLSRLVMDECPLVLEPSVESPLDKWAIPSTNHPLRHQTAVTPADMPTITTLLCDLEREVSMVHIVPWLEWMVTIALPIAMGPLDVSTPSIFSTPAASDKLARPTTRLAFPPVCGLIALLCHRALSSHATPDALRLRLVNVLCPDSQFAYQDILEEPFSILRCDPRIWRYGPLLGLVLDLLGRFREVSALHLRQLHGDDAIHATPTSTMGAMDMSQYILVQDSIAVHALLNVAERLNAEDAQVQRRRIFTWLDYVFRQTPTLLLAVHSQGYAKSLVHLAVRELPSLYELMPSMPDLLSTNDLAKLVFRCHLASALFKKYPDAVAPSVLKGVVAKVKLVYDTDRSQTSDKLLSPDVVDFLTAVLPALGAMAVSFCDIAEECVQLLMKLRVQVNHQRSDTLNASSAVDQLELAVHSVFAQIVRSSEDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WFH5</accession>
    <name>A0A6G0WFH5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_015770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000232">
        <property type="protein sequence ID" value="KAF0725805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WFH5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001875"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0725805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="124" mass="13622" checksum="BD617F787EB479E3" modified="2020-08-12" version="1">MLVRGNRTSASHVANLIESPDGAIFVAEADNQIIASIHLEKPDKMYAVTVHKDWQNKDIGTCLLQTAAAYAKHTLGMTKLQGPILTSRTDLFEFYERLGCVRTGILVDHPDGGGLKGEMIMRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WHD3</accession>
    <name>A0A6G0WHD3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Adenylate kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_015208</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000213">
        <property type="protein sequence ID" value="KAF0726584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WHD3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020956"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019205">
        <property type="term" value="F:nucleobase-containing compound kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22967">
        <property type="entry name" value="DD_AK7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047499">
        <property type="entry name" value="DD_AK7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007858">
        <property type="entry name" value="Dpy-30_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05186">
        <property type="entry name" value="Dpy-30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="450"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="586"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0726584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="695" mass="77037" checksum="7ADE363A297C879C" modified="2020-08-12" version="1">MRVFVGNLSSVLGMEMAKQISQTCQVVGAVETLKQTQVVKKRLAEFKPPERQDDDKPVETPVVVYSDKHNVHTLLKRSDVAIYSILDDPDGVVDALQAFEDGGAGESGGEKLFVAISSVLTWAKTPNPTPLPKEWRGHKEEMFKQRKPARKYAEYKAIETQVLSARREGLKTLVVAAGLIYGGAQSHFHAILRDAWMYPNKDLIVPSVGGLKGANVLPMISVYDLAKIAANVALASPASSGTNYMLAVDQSQSTLRDVCLAISQALGNGNLRDVEAAEADELAVKDKSLTPLQLDLRFDLTGAALETIEIDWHFQQGMVANMAVLTQDYLQSMDLRPLRVVVLGPPRVGKTYLASSLAKTYYLPHLTAASMADEFLATPKLDDALVEVRDQVKACRLNLNELSDAVLTQLVRWKLASPVCRNQGYVLDGLPITIDQAKAFFFVEPKVAAPTEGQDGEGKADDNTEEKEGDENNAAAKKASAPPNLFVPNRVIVLNATKALLEARAQQLSQEEADKTGNNAVEFARRYDLFRKNDGLVNHFEKENDLEVLELELEGEEMYASKKDYLDPIAKYMEQGGKPFNFHPTKEELLEQQKELEKQLAEEAKAEEKRQADALEKEAAEKQKRVLSEKSRLEVIQREEMDILEARSKPLRAYLMETVIPALTEGMLEVVKVQPEDPIDYLADFLFKKGQDLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WHX8</accession>
    <name>A0A6G0WHX8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Band 7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_015052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000207">
        <property type="protein sequence ID" value="KAF0726796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WHX8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010311"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050710">
        <property type="entry name" value="Band7/mec-2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327:SF9">
        <property type="entry name" value="BAND 7 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327">
        <property type="entry name" value="STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="1">
        <location>
            <begin position="60"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0726796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="497" mass="55923" checksum="FE4A30C1A2C0DB12" modified="2020-08-12" version="1">MAPTTAAPTGTAAATASQTHLLFDHIWRVDKANEKFGACKNGSTIVILQPGRNPVMPYIRIPDGMYAIVQHHGKDLDYHYPDGRTSPVWPAGFHFASIFTKVEYLVTKQFVVFDTPVKGCKTADDVTVHIDMNIVFRITGDKAKGEDPNMLRDAQEEAVRALARSVEHTEVYSLRDGTLKERFKNDLQLRPPVPMAPLDEEESADETPLLDQHALKRFETVDEVWEEPPPAKVVYCVTEDIKQNLNKQFNPYGVQIVSVAITNVLLPRNFEVQMEEKTTYNSAIKEQTMKQQSDMQLLQYKEEIDTTKLSKYMRRMEETETGKQKCAEIQKEIDMIRADTKKLQTQISQDMQVRCSKIVADTDLAMAKVKAETEMIQAEINAACDAEITKINAEVEALKLKMEAEIANIRTVGEAKAKEIVSKAEGLAALKLEKQREFLLKMQRLDVKQAMANNEHVVITGNGSNNLMADVFVAQQKSNLLINLNGQDALLQGRRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WHY4</accession>
    <name>A0A6G0WHY4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Trichohyalin-plectin-homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_015037</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000207">
        <property type="protein sequence ID" value="KAF0726781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WHY4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003315"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0726781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="183" mass="21241" checksum="A4F70DA80841FA5D" modified="2020-08-12" version="1">MQRVPRSIVRQFSTEPAYSFVQARRAYLAEVSELRKVYMKQEAARREKLARDQAAERERVLKAKAARLEIKRQMQAVRAKEVEAEKAAHAEFVAKRFEEKKIVREQKAAEIEAKRLAVLEQLKEQSKTWISAESVEDQLAEAAFVTKRKETSDNKVGNLGALSWLERLKTMKPIENVDEKERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WIA3</accession>
    <name>A0A6G0WIA3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_014929</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000204">
        <property type="protein sequence ID" value="KAF0726938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WIA3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003227"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052050">
        <property type="entry name" value="SecEffector_AnkRepeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586:SF3">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140860">
        <property type="entry name" value="Pseudo ankyrin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0726938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="459" mass="52671" checksum="53EE3136D457B8AA" modified="2020-08-12" version="1">MEVLCVPGLMDVVTQFQPGLSLDMAPFAALAKKLSHQSFFVDSTATAISNLFTPWLDRFGTGRLSRLFQELPFTLRWATYYAAWNGRLDILEFIHAEYDQVRQAPDLLLSAAAQGHFHIIQFLLSIQYRQEKGHQSNPKKWSNGTAKEFFLPTPYRPLDPWEVTTFRVVERGDLATFQILLPNMEPWYAQLALGKALIFEHAQLVDVLLEHLKDLPMDPRSAIEAFASVQGRENLEILFKLWQPYMSEEYLIAARSVALKAAVKNQAVEVVAWLSLELKAMRQDELLLYLAIWTWTERPKLAPDILAIVKPDLTLTGDMIERLVSAATQWKELVPLLGTAQTISEAERNCLAKVLQKREMENLVLIFKHRNLQACDIKQVFEQDDRRKHPAKARADRLPITVYLTRYFVQQGHLDLVRKFVSYNIVTAQVAVKFLKEAKIDVKTWMIDDDSDSESDEDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WIP8</accession>
    <name>A0A6G0WIP8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_014846</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000202">
        <property type="protein sequence ID" value="KAF0727110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WIP8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011526"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031251">
        <property type="term" value="C:PAN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3700:FF:000001">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex subunit PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030844">
        <property type="entry name" value="PAN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041332">
        <property type="entry name" value="Pan3_CK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12272">
        <property type="entry name" value="DEADENYLATION COMPLEX SUBUNIT PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12272:SF11">
        <property type="entry name" value="PAN2-PAN3 DEADENYLATION COMPLEX SUBUNIT PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18101">
        <property type="entry name" value="Pan3_CK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="185"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="21"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="557"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="563"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0727110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="581" mass="64376" checksum="C5191A9385080406" modified="2020-08-12" version="1">MASSSNANRYGYGNTSGFANSLFQPPSGSQERTYTSPVKSSGATPRTMWTPPRHSGATRSTTSAGVSSPISSELTSSAPPFIPQQQLVSEPLVQVTRGGCIFYVPESEVATGSLHVEVPLATTPSSTSSPIVATRRSLASLALAPSIRRQLDAQHEEMVRQIDPSDERYKEIPSQFTCMWPLDHDTVHHRNVAGSFGYPSHSYKVLSETDGRTYALRRIENVRTTPAIVQQAVETWKRIVHSSLVPLHRAFVSHGALFFLCEFYPGAVSLHQKYIAASAAPSEAFLWTLLTQLSGALRVVHAAQLACKAIHARRILVTAHDRIRITGLGVLDVLEYDSLKSKPRVESLQREDVWNVGKVLYAVASRREWHASNQLQGLTDMRSIYSSTLCQIVENLLDQTISNVQELSQPLHDHLFDELDTQARLADECEHQLASEYQNGRMLLLLMKLGLVNERPELYQDPSWAETGDRYLLQLFRDYVFHQVDEMNRPVVDFGHVVDCLNKLDSASPEKILLSSRDGQSILVASYAEVHRCVQQTFSDLLTAAQRRPVHVTPVAKSIPMRGRGGGRASRGGGRGRSGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WIZ7</accession>
    <name>A0A6G0WIZ7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_014731</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000200">
        <property type="protein sequence ID" value="KAF0727202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WIZ7"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0727202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="88" mass="9836" checksum="AF3E7AF8B19F75C9" modified="2020-08-12" version="1">MVPTNRQPRGTRAELDGVSTRESVQLASICAWLDVDAGIGSVTTPTKREHTRFGRTHNARTQADTFMNSLMRFVDNRRVEGLCTSLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJ37</accession>
    <name>A0A6G0WJ37_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_014737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000200">
        <property type="protein sequence ID" value="KAF0727208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJ37"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000122"/>
    <dbReference type="OrthoDB" id="76760at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026131712" evidence="1">
        <location>
            <begin position="24"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0727208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="105" mass="11911" checksum="9F96540BC595769E" modified="2020-08-12" version="1">MKFITCTRFVTIMAAALTTVVEGDNRTTFAADEPSFQFNLDQVGGFPTDDQLVIMDKWTSTDFSSHTDFFLYSPRSPRNQAAISRFSFRQRSFSGNFSEVDIVMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJZ1</accession>
    <name>A0A6G0WJZ1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_014396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000193">
        <property type="protein sequence ID" value="KAF0727568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJZ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009735"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0727568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="33676" checksum="1618B9319F17676F" modified="2020-08-12" version="1">MLARRVRQQAMRWRRPGSSRRFATDGKEKTAETAENVAAAATPAPPRPGFFSRHPEIIFLGGLLGIGGYIYRSSVNNSKFNELQNDIAEKTPISPYEAYELRSQNTISPELFETIKKQAKRYFPSNEATVAEFDLCLGSVLKGTAMKNTHHLERVLLSLPKNANGKVNLDLLLVAFSLAVKGGVDERLQCLFQLPLTGTAVTDATLTKAQIQGILGHILETYQIPSEKRVVALEDKAYPYQEYAVATPEQIFTAAVGALVKAKTLEQDIEAYNLEQFNLLMKSKAVCIWGECYNSSSKKRMNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WKA1</accession>
    <name>A0A6G0WKA1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_014320</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="VJMJ01000191">
        <property type="protein sequence ID" value="KAF0727695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WKA1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009169"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000035">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000578">
        <property type="entry name" value="probable ATP-dependent RNA helicase DHX35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF136">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX35-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="47"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="241"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="707"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0727695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="736" mass="82070" checksum="1A7B9654E890E695" modified="2020-08-12" version="1">MSFRQPTSGMWIPGVKKAQMSDRGEEQLPPVVSVTSLPIESRAKEILYAVETSSVVILAGETGSGKTTQTPQYLYRAKFGKIAVTQPRRIAAITVAERVAAEMGVRLGGEVGYAVRFEEKWDAERTGIKFLTDGMLVRETMLDPLLTHYNVIMLDEAHERNLETDILLGLIKKILKQRPDLRIIVASATLHIESFVKFFSSVSHEKSDVKQPVVAISVQGRQFPVDIMYLKEPAANFEQKAIDTVIEIHEREKPGDILVFMPGQDEIEYVVQRLVTMGSPTLLPLAFYGSLPANIQQAVFEPTPPHIRKVIVATTIAETSVTIPGVVYVVDTCLVKLPFFNPLTGIEALITTTESKAAAKQRAGRAGRMRPGKCFRLVTEETYRTKFHKHTIPSIQRTNLAPIVLHLLSMGIQDIVHFDFLSPPTPEALIRALEVLYSLGAISQECRLIEPLGAHMAEFPVDPFLSKMLLSSFDFGCTEEALTIASMVSVDDIFINPRASKERQAKLKECVAEFAHQQGDHITYLHIYNEFIENDASRSWCDEHCLNHRILLRATEIRKQLHRYVKRFASATDKTIQSCGDNVKPVLQCLVAGFFANAAKLHGSSTYRTIKDGRIVHVHPTSVLNTFIRSPEWILYHQSVLTDKEYIREISSIDPRWLVEAAPEYYLCKEVSSVVSGSSGDIGLPKAAPAKPTQQQAATDANGRILFRRPTSQPPSKKPKLPVHIGKSKGGLRSQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WKH6</accession>
    <name>A0A6G0WKH6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphodiesterase</fullName>
            <ecNumber evidence="7">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_014275</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="7">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the cyclic nucleotide phosphodiesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="7"/>
    <dbReference type="EMBL" id="VJMJ01000189">
        <property type="protein sequence ID" value="KAF0727761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WKH6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020631"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0140">cGMP</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="10">
        <location>
            <begin position="680"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1013"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1024"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="767"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="767"/>
            <end position="771"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="771"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="806"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="807"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="807"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="807"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="915"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="915"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="968"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0727761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1036" mass="115782" checksum="023E2485BD5080B8" modified="2020-08-12" version="1">MTEGLHLMVPKHILENVVEGTKTLLSEKRVLNQKLDEANVRIFALERQLADQQLRAEVAMHSMAKSPPKPATHRFKNLTLQVMKTKMPDEKASDDLATVGKKDLEINKLLGKTNELETLLAATRAITHQTAHREVVSSTLNAARNLVAARKYTLAITSEGKSTINLYSMGAVSLMEEKPANKYGGFTDEGTVSVDNTTTFGHVMMMGTVFDAMQATTTGMFASQMEDLDFTPHSVLCVPIRNAHGTILGALQVVTQRQHSDEYMHNQVFTSLDKERLEHLCVVAGSAVWNLRLSKERQMAQSRIEILLRLNRSIAVEVNSAALLEKIMDVSYELLRCECANLYLKIQGERDLFVAHGSDHVRGQYVSIDKGIAGLVARTGQVVTTNNAIEHPCFDKELDERNGQTTRKVLCVPVKDPEGNILAVVEATNKLDSSDFSVEDTLFLNYIAEAAGISLHKAMLLSEVIIAKRLTDIRLKLNDYVLHHSDIHSLTDLIMVHGKAIMECDRFGFLLVDHLKNELWITSNNGNLGDQVTVRQPIYKGISGLVATTGETVCTRDAYTHSLFDPTHDNLTGYRTTSVLCMPVFEEHVPSKPKVVAVAMCINKLQGSQVIAFNDQDKTTMSRLCTEIQFALGQMSLEVCYFKVVSDRNLSGNSEVTEAGIISSLLQKYSRNHASGIMTSKTADELAVHGSIPPAADVFGRDIKLTQRPELDQWDLDILSFSFTEVIQSVQTLFRAYGFVDAFAISNDKLAAFVASVAQHYRANSYHNFYHAFQVLHSAHIQIKAHMRKLLTGVDIFAVLIAALCHDVDHPGNNNDFEVKCMSAIALTHNDDAVLERHHCRVTFLILNTPSTNILEKVAPDAFRAIRRTIIRCIMATDMASHFSQCKTIENLTRHQFQDPSNRMLVMELIVHASDLSAQALPYKLALKWGERALDEFQSQAREEADMHLTVAPFMENLENKGTRLKVQSNFICYVLQPLWMSYGQLVPSLRFYTDSLNANLDHYRADLAEFNRTQQQQQPPPQLSQQQLPSSVPHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WKL2</accession>
    <name>A0A6G0WKL2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_014225</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000188">
        <property type="protein sequence ID" value="KAF0727788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WKL2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019134"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00106">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF15">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="12"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="362"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="515"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="108"/>
            <end position="115"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0727788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="646" mass="71116" checksum="8E5B9F399F27CF34" modified="2020-08-12" version="1">MKPNDGAMTTERVRVYCRLRPFVRQESTEPEDDGTFVTGATAESRRVSIKPISKTSVKLQDNELQSKEFAFDGCFPEESTQQVVYNTVAKDLVESVLTGYNATIMAYGQTGSGKTHTIMGKQSEEDLGILPRVLRDLFQASSQGVKFRVNYVQVYCERVLDLLGMSTSPSTLQIRESDERGVFVDGVTLAPVASVNECMALMERGNANRAVAATNMNAHSSRSHAIWTIHVERTVSNDGASEQIVSQLHVVDLAGSERVKKSLVRGTHATELRAINLSLSALGNCISALAKGQSHVPYRDSKLTRILQDSLGGNAKTVLVLTVSPDATDVNESIATLQFGQRAMDVPVHAKVNVIPDYKRLVDILQAKLDSQSDRVNELDMELQAARQAQAHLVDKLEEAKLETSQALFELQAAKASKEISIQPGADEKSDDASAWEAQIAALVHAHKTELAQLKTRYDQQIETHKQVANRANQEWHNIEHELSAERTAHLATIQDVREAKEKLWAFEQDTTTRISELCQETKDLETQITKQTQQIQSLQANNQALAAKIATLETNKSSMEASIESHFVSRAQVNEMETLYADAIAKLQNRVESLESSKSQRNLVAALLPIKKGPTPPSLGPPKPDALMPRKAVAKIGRVVPAGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WKX3</accession>
    <name>A0A6G0WKX3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_014065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000184">
        <property type="protein sequence ID" value="KAF0727954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WKX3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018640"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0727954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="123" mass="14680" checksum="B58041496D754439" modified="2020-08-12" version="1">MKLYDRVFIHGRPNFPWTLANFKKNVEFWWSEWNIDPDFETSWIAQISERVAVLFSPNELGNEANMLLDQFPRFTNLRSLELITDETWNLEDLFDFLADESQITELELHYRGTADFVDIEVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WLF6</accession>
    <name>A0A6G0WLF6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_013953</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000181">
        <property type="protein sequence ID" value="KAF0728127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WLF6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018790"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052582">
        <property type="entry name" value="tRNA-DUS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45936">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45936:SF1">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0728127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="394" mass="43317" checksum="20D75FAC4C5840CF" modified="2020-08-12" version="1">MDSKLYENAVCLAPMVRAGTLPLRLLSLRYGADLVYGEEIIDKKIAATTRIENKALNTIDFVSRESVVFRTCEEEKAKVVFQIGTASAVHALQAAETIAKDVAAVDINMGCPKHFSVQGGMGVALMSKPEVASDIIKTLKRNLNIPVSCKIRIKDTPEATIDFAKGMELAGAAAIGVHARQAHERPVDDAHWDALKPLPSALSVPVLANGDIWTQEDIARVRAETGCQSVLIARGALSNASCFSAAGIVPYDENIKTYLKIAADTDNVFQNTKYNISRMLPIQETTTVSVANIADTKSNADLYGLFNLREYYEAKQAEFEPFRQQVFNVPDRAYDDAHVRNQELYCNVCGIQLLSEQDVALHEKGKRHKKKMRTLASQSVLTTPAAKRGKFDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WLT3</accession>
    <name>A0A6G0WLT3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb/SANT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_013897</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000180">
        <property type="protein sequence ID" value="KAF0728246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WLT3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019533"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024752">
        <property type="entry name" value="Myb/SANT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47072">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47072:SF4">
        <property type="entry name" value="MYB_SANT-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12776">
        <property type="entry name" value="Myb_DNA-bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like" evidence="2">
        <location>
            <begin position="2"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0728246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="211" mass="23932" checksum="9CB0280ADAED62BE" modified="2020-08-12" version="1">MSKIKSRLDCLKKDYKDVKFLRDNSGFGWNDDLGLPTAPNEVWTAIINSNSNCKKFRTTPFPLFDSLTVLFDGSYADGRFCLTPPNTSNSFIGEGTISRPRVSIQRKPQRVAASDIDDSSDLDSDDLTPPPKKMKQQIQKEIVGVQEVLLEMQFRSLWKSKQVNYNSMTPTTGCQRPSIAFWRTTAIWMAPSLPTLLESWEKASMLQSLWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WM87</accession>
    <name>A0A6G0WM87_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Vacuolar protein sorting-associated protein 52 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_013779</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS52 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000178">
        <property type="protein sequence ID" value="KAF0728416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WM87"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011048"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007258">
        <property type="entry name" value="Vps52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048361">
        <property type="entry name" value="Vps52_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048319">
        <property type="entry name" value="Vps52_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14190">
        <property type="entry name" value="SUPPRESSOR OF ACTIN MUTATIONS 2/VACUOLAR PROTEIN SORTING 52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14190:SF7">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20655">
        <property type="entry name" value="Vps52_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04129">
        <property type="entry name" value="Vps52_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vps52 coiled-coil" evidence="6">
        <location>
            <begin position="61"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Vps52 C-terminal" evidence="7">
        <location>
            <begin position="258"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0728416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="686" mass="79024" checksum="8C15CFF045EAF537" modified="2020-08-12" version="1">MMKTEDVLEDIDFDELDDHLEQFQQDDFIKEALAKGVDLRQYAQQIDRELRDVEMESITQYVAKSADIVDLYNQVQACDDILARMQEMLLGFQADLGGISDEIRNLQNESIEMNVKLRNRREAEEKLRIFLDQVYIPPTLIEGIDDGDVNEAYVSYLMILNSKLAYAKLNEAAPTSLGVVPAQAKAVQQVDSDLDKLKLRACSQIREWLLGRINDLKKPKTNVQIVQQSTLLKMKYLVEFLNDQAPSLANEFRDTYADTMSRILVGVFKAYHTGLMKFVEESATRTDVIAVEEASLKSLFSSRVNAKQTNAFAMGDRDKILEEALQPPILVHMAQAENLKCSYEVLVRSTQIHLINAATSEYLFLLDFFKATESNNPVRIRELFLRVFAKTLSLSLEQLENYLCTCYDAIGLLLMIRLTQSHRQVMEQRRIPVLDTYLDRILLLLWPRFHTVVDLNVQSVKQAKPKKLGSVELHPHYVTRRYAEFVASLLGLIPEGGDGEAVYVSMAALREALVELLEKLSENHKSSKEKCVFLINNYDLVVSVVQERKIASDETSKFEELLVAQRERFVEEELLAWYGTLIVFVQQTESKKPETLESSKVEKIVKEFNAHWKAGIEKMNNNIMKYFSNFRNGMEILKQVLTQLLLYYTRFIELVKKSWTRPPSFSNDIVTTQEILYEIKKYSRSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WPM2</accession>
    <name>A0A6G0WPM2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PLAC8 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_013050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000166">
        <property type="protein sequence ID" value="KAF0729304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WPM2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018380"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006461">
        <property type="entry name" value="PLAC_motif_containing"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01571">
        <property type="entry name" value="A_thal_Cys_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15907">
        <property type="entry name" value="DUF614 FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04749">
        <property type="entry name" value="PLAC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0729304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="194" mass="21338" checksum="47E0F6BC7BB7F0A8" modified="2020-08-12" version="1">MQFKLGQVVETPVLERTERSATFMPGHVPFMPIVDNNGILVGEWQSSVYSAACDDKMYCCLTCFCPCVSLGQTMARVGSCGEGYVVMVSMFYLILIIFFAMWLAHLQDNVVLNVFFYLMVFIAVLTFLTTGAVVGFARAKIRSLFKIPGSEISDVISATFCSCCVLAQMAGHVQANTPGQCTLRFIDTLPGYDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WPS9</accession>
    <name>A0A6G0WPS9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_012902</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000164">
        <property type="protein sequence ID" value="KAF0729401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WPS9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014445"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014446"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0729401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="512" mass="58430" checksum="B1DECECC7B23A472" modified="2020-08-12" version="1">MQLGEDGVSSPENAKRLFETDRKRKYRANKLNELIELEAQSRRLGAYLAQLQAKNRARQLARSKGENKTLRFQVNQSQCLMQMLSLWAQINERPQRALSHQTTWIETTLLTHPITRRQGIEWLSERVYHQACRVLPLNYPNRGRVDDDIGLDVLRSDDLDEDGVTISALKTHYRFSTCANYKSAAQVHWSDLIGAVSAFTNELIDRVDDRFLYYYHTNHRLGTSTLTIAGLFQDKDKVVVTNCFVAKDELFPLSENGLRPHGFNWTVYEAITPDLTLVHNLAVQYTPITAKGKLIPLEKIGQLFGRSAEGVQYRETYIEQIRNAAEASFVSLNKPMIKRLSDLDDLDEDGSTIAALETRYRHSTSTDYYSAASSHWETLLGVNSRISKELIERVGDRFMYYHHKYHFIGTNMLCIAGDELFQHPQNVLRPHGFSWTVFEEIAPGFTRIHNFAIQYTPITANGNVISLDTIGRLFGRPLLGSQNRNAYIEQIRSAAEAAFVGSHKAIAQESRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WPZ6</accession>
    <name>A0A6G0WPZ6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_012939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000164">
        <property type="protein sequence ID" value="KAF0729438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WPZ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015303"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0729438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="526" mass="60108" checksum="666908B1D5FCBAAC" modified="2020-08-12" version="1">MGHKCKPRSKAPLDDSYYIDIVGMGYSPDYIELYTKFVEKGLNPIHITPKDVDASSSVCNEDIRIYFASKDIPEQLQMGPDKRPIQQLIFNLHKYPVKGRNDNTQRVGRFRDASDYCLDLDSDNTSDEDNSEASQHSETSQGEAPVEKSTESQHSLQESTPKEKLTEDISNAGSEYIVVGRKRKANKSPTLATDQASTSTTWHSPNLFELLEDMQPSVIINPPDNTTDTTLTRCPLLNMSYKKVSVDRSDAKITQRLKKATTLDGRPAKIGVNQDDWSIQDIVQTMVSTADQNNSTKHPESTITAKQTYLKLASKLQSLAEWEKCLEHIREQPLGGYLALDHIRRTNRGEYETLVSRHFHQRLQSATFHTDVMNTKHRFQMLFKRKHTTRDNSIEAFSQLPQQLTPTQLQTELFLAEWDLLLQCIAPKLYNCDAWVLYFTKHKVNWLPTQHMRLLSTDSLHRMLQSSVGVAIHKWLHSQEWNDSFLTAMTAVQDTNVTPAELTLVITGDTENQKLEYQPLHYPLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WQ97</accession>
    <name>A0A6G0WQ97_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_012819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000163">
        <property type="protein sequence ID" value="KAF0729551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013294"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013295"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="564"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1366"/>
            <end position="1415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1499"/>
            <end position="1565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0729551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1565" mass="172355" checksum="6CAF99ACA99498B0" modified="2020-08-12" version="1">MDDSSDRATKLAEAYEVDVALTAANILERVQTKGRVSVVDLISQAVEKPMAWLYDVVCTVESSGRVVRDVVNDVEGWVAAVEEMKPSPAAQIPQIGPLLASILATTKEVSSRQDLTTLVDIFVSEDPAIQSWCDENYKESLVDRVEDNLLAMKILHESSTPESYQWRSAETTNYWTQELDEVFPREDELVEHLAQDPVYLFRARTAESFSSLLQAFRLSLPPSSKFRHWWISSLEAPVNVILRQFGRRNILLSDPNSTVLQWNAVALIEQAFNCRKITPPPTTQFAWRLDVVRTLVEVAKDTFFNREIKFIIADKDIPLTSMTTIAEAPPGTASKQAFVSQIVEKMKQRTLVDWARHETNQLNINVAQCSIESSTHAPSSFAEEQPMDSTHTDTNSSSGVIPQPVGFDQNLESSVAIVAIVLDRHGYFPVSNFMAWIKTLGKKKLGGKTHDEFFDVVVSAVSLFATVTSDAPQMFLKKRKISSQMKHGANSAAKEWADRYITKTEKEIEKARLKLFQACLEKNPEGITNAINFIRSEPLHLKLAKDIQVAERILDSIAEKKPQAIDQSTKKATESSSSPVTTIKKDNHIGMESASDELQIAIEAAVEKFTTIALKWLATNSKYHVADIVGQTKTSPVQGVTNEEFADKIVDRMKQDKRLEFAVDPKGRPVFMLSVQNSEEEATKSSKELELAIQAEVEKFAIYALNTLGNNKYFYVANIEGQVKTSPVKELSRDDFVARLVDRMKIDKRLKFAVCPNGKDVFVLPGSQPTTTQPSAALENAVQAAADKFTASAIKALAKIKYYHVAEIPGQVKASPVKGISKDDFIAHIVDRVKQDKRLKFATDPCGNPVFMPNPQSSKVASPENVKIAVQAAADKFAASAVKALATNPHFRETEIKGQVKTSPVNGVSSEDFIARVLERTKQDSRLKHAIHPDGGLVFTLKAQSSDNTPTKSPAEIAIQAAVSKFTTYVLSTLASIKFFHLANIQGQVKSSPVKGLSKDGFVNLIVDRMKQDKRLKYDKDPKGNPIFTLTAPSKEPATPKPAKDLNAAIKAEVEKFTTSALNTLANNEYYYQAEIVGQVKASPINGVSREDFVAHIVNWMKQDKRLKHDNSPNGKPVFVLRAPKSAAVTSSMELTQAIQTAAEKYTASVLRYLANAEMFYVAHIQGQINASPVKGISRDDFIACVIDRTKQDKRLIYAVGPNGKPIFKLASSKSTIYQLKAKETTDEKKANSTEPKATTAILSKKVEESEENEKLPAGTTGMASYFQQVQEEETLLKDALDAIQAESMKSLELGNSILLEDIFNAIEIRLPVGTTLDILAIKLNDSLNSTLRVDLDAHGQATIVKVAEKDRRSVPLHQMTTSVVASGADGPAFPPAFDDASQMWGSQQNGPFSDEDADDSSDSSIDSGESDISSDDELDVEMHLAEDIPEDFLGIQNSHQLTHQADEITGVSYPAEENIHEARLASEGNVVPRNPVTQADQVHVHLSKDDINEDCPGIHNGHQLTEIPRDSSSAEENKETSLGDEGDTVSRSQTIPQDAIDIPSVPAVLTEPIKKSPEENCVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WQP8</accession>
    <name>A0A6G0WQP8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_012666</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000161">
        <property type="protein sequence ID" value="KAF0729775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WQP8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016330"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0729775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="500" mass="56007" checksum="3A4C47FA66197A9E" modified="2020-08-12" version="1">MDAQLILAATTASAILGAFLIRYLLQPHPLDKLPGPKARSFLFGHALDSIGSVADWRNNDTYPEPYLKWAREYGGAYHIRELGMHVLQLTDPKAIQHVLITNAPNYSRDTLFDSYFSDIMFGNGLLSTNGAAHDGMRKILTPLFTTSRIKTFLPIFVNQTKRFCDQLPCDKAINMAEAFQKLTLGVIALAAFGFDFDAHPEAFEAFQASQLEFTPFTLIGIFLIPNFLRWPLPQLLRRRKAHNVLKKVMQDVINQKLTAPTKEATDLLDLILPSATENEALVHTMTFMTAGHETTSTALQWIFPVLSSQPKAVARIRDEYAHVMAQHGSLESWEAVGDLKYTLAVIQEVMRLHAVAYALIQRIAQGDDQVPLSDGTSVFLPKDTAIELNIATINRNPKYWTNAGDFIPERFIEGTDAWNADLALRDGKSHTFYYFPFSLGSMSCMGQKFALIELQIIVSTVASTFDFNLTPNANLRHQFTGIAMRTVNPEMKFNRISPCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WR91</accession>
    <name>A0A6G0WR91_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_012560</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000159">
        <property type="protein sequence ID" value="KAF0729921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WR91"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002609"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03213">
        <property type="entry name" value="ABCG_EPDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001480">
        <property type="entry name" value="ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF139">
        <property type="entry name" value="PROTEIN SCARLET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="776"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="862"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="888"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="922"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1006"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="47"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="453"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0729921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1032" mass="115414" checksum="80AE2ACC61B6BF15" modified="2020-08-12" version="1">MGHCLSSEVMPDLSTVSTTPRRSHRATNQSKFHMDEPQDLAIDWSQFQALVPLRQAFFIPPQSIQHVQELPSNMHAACRVYIDGEAITLKAALQDSSDEQEMLQALVREIKHMSRIHHPNIVDFRGFTVVKPFGLCAAFETMQSKSLWDLLCHSTMAARLSWPKQKIQYAIEVCRALEYMHSLRPKLIHRNVKASKVCLNHGYRIAKLSGFDMARNQTFERTMAKAGSSDIQWSAPELLIDGDYSELVDIYAFGVLLVELDTCQVPLQDVARGMSELQLRTVLRTGRLRPAPSAKCPPEVANVIKHCLQFDPRNRPSSSRLLKMLLTAQASLNNLSSTMFHGVSCQVSMDPVESLRRKSSFPVLQCDDFIHIHHAAISSTVFVVFEIVEKSRTIVVNLPAFHTTDVDLVIVNFEFYKVIMDTKSINSTPAAYDCFVTVETPRPSVYAAPKMLLEWQNICLTVKAKSPEAVKTILREVHGSAAPGQLVVIMGPSGAGKTSLLNVISGRNTSFTGSVLVNGHPWTKQMNKFASYVLQDDIFYHSLTVREHLMFQAQFRMGRDFTPEQRTNRVDYVIDELGLTKCRDTIIGNARVRGISGGERKRLSFATEILTNPSLLFVDEPTSGLDSCMAESVVQQLQKLAHDDGRTVVATIHQPSSELFTLFDQLYLLSDGQTIYNGPATEAVAYFSSQGMECPLYMNPTDYFMKQIIVLNPQAAERVATLADAWRNHVPAVSTTVENHETALLLTDRRTTYLSSPAQFVVLCQRNVIRLLRDTMAFQARAFASLFIAIIVGLIYLQLDLSQTSVQSYTGVIFFVIVNQFFSAVNPEFLSVPFELPILTREYRGGLYHIWVWYAAKNISELAFQLFFPMLFLVPLYFMVGFANDATLFFSFYLFVVLIGSSAVGLGYLVSSFARTPELAPIFGIVIILPFMIFGGLFINTDNTPSYLTWLEAISPMKYGFRGMSRAYWSTIDSIPCNAGESCAFSNGTQVLSSLGLDHGSPAADMGYLLAINIGFRLGGLAFVLYNTRRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WSH7</accession>
    <name>A0A6G0WSH7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_012370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000155">
        <property type="protein sequence ID" value="KAF0730377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WSH7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012500"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="521"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0730377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="579" mass="61544" checksum="A72C8D6B9E8CF568" modified="2020-08-12" version="1">MSTKSENTTPEPEEEVSPFFKACRAGDVEAVKEFLRDLDIDVNKPDENGVTGLIAASETSLDVVDLLLRDDRIKINAVNNEGISGFMVACGSGNVAIVSRYLEEPTLNMNHMNSRGMSGFVVACMVGRTEIVELLKNKPQIDQLHLSMGVYFACTSGSVEALDILLALDNVDVNIADPAHGNTPLIVASQFGHTKAVERLLKVENISVNHQNKHGGTAFRSACSKGHAEIVDLLLKYPGINTDEVSEGLVDAIGNGHSGLVKTLLAHPQVDINHAVNPSGSSLHVTALALAAASGQTSLIEELLQIPLIQVNPVDNTHMSALVQASFTGQLDVVSVLLKHPGIDINQTNEFGNNALFAAVAHGHVETALRLLEFSALDAHNVNQVGQNAFMIASCLDQVEVVNKIIARPGLDINAADADGKTALLLACSKNAVQALPLLLAHPDIDVNKTDNNGSSALLIACATGNKEILRLLLAHDKIDVNQKNKDGTTVFFGATLNGALEILPILLADARVDVNAKDGRGNTPLMAACMTRQINVVKLLLTHPAVDATATNNEGKTVQDIATSNYYLDISDVLVALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WSW0</accession>
    <name>A0A6G0WSW0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_011940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000153">
        <property type="protein sequence ID" value="KAF0730517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WSW0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015884"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010828">
        <property type="term" value="P:positive regulation of D-glucose transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090314">
        <property type="term" value="P:positive regulation of protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031340">
        <property type="term" value="P:positive regulation of vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038983">
        <property type="entry name" value="C2CD5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057815">
        <property type="entry name" value="C2CD5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056430">
        <property type="entry name" value="C2CD5_YbjQ-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056431">
        <property type="entry name" value="C2CD5_YbjQ-rel_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37412">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37412:SF2">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23025">
        <property type="entry name" value="YbjQ_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23028">
        <property type="entry name" value="YbjQ_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23128">
        <property type="entry name" value="YbjQ_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="435"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="658"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="851"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="615"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="442"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="855"/>
            <end position="870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0730517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1046" mass="116188" checksum="175D3590799F8619" modified="2020-08-12" version="1">MPCTIKIRLVEARGLPVVDRASKVADAYVDITFASFEARSSVSRKSLTPCWDEEFRFDVVDDAVLQSQPIMFKVMDHDVYTTDATIGIVYVDLNCILMKEGCSVQGWYPIYDTLLGVRGELNLVIRLHYFGDINPFRESSAGVQFFSLSTLDPAIFTTHKMLGFVEELVVHADPEYSWSDSFRTSRKSNEYRQLLLYKLSSQVSTLVGKKALDLGGNAVLGYRQFFDVEGDSGMVARACGTAVFITPTDKSDPTPPTTLMMESSSVSSMPSESDIENLLSGLYVKRSIGDEPVASDPEQGSPRIASLSLRKLAFKRRKDNFELDAHDEIQLLTVRAFHPDTRIRLGGIVSARSVKYLGRMATKLADQETRDSWWQELREEVRSHAQSLQCSFVIGYNESCTIHDDVCVLSASGTAAVVKYAKKVRRPTLLIPASSADGPQVEENSPNMRPVSISSTHRRQGKSTNVFNESPCIMCHVPYSRSMAPFSNMRMVRCGVCGRKWVPEMLLSSTEPLCAMAITGSGTFIQARVCRQRRRGTGDTNATIVSEALPFLEYEMHRQLTAKMRVLGVNALFGFESQVQISGGFVVGIITGTGMYLPALPMPQGLRIARNIDVKDEEDRRLVQLQAQIETISNRNRALMKQDTMCVIPAEYNAERMRMDSEDKAKRTALRKLKKRDGSSQVDSRKQSMCDDPSSAGAVADEEKLDSSSDSSSDSDDDVNADLNQDNKNPFVLEIDDETDEDLMSVLLEQPLPEGISICNTDSLPGTTQCGANIHLFLSVKRVEWDEEHTRDTRVNVLFSHVFKMLFTSLIFKLRAFAPCVVCGLRTRVALAGDNMIEVVLMGMAMLAGPGGEPSLEDDSPNAPDNESDDASPSLRLQILNNNANFITPASPTKDLSVPSAFTHSREWIELTPLSYVPGAKILRYLGRITLHFIKESWTVREIGGLGAFFHLFLSEAIAVVRAHVRALGGNAMLSFRLVPIESSQLYRNQVYNMISVTGDAVLLEREQNPLPVGWHTSPISRDSSHVDYFSNNDTPVPTYRRDSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WTV9</accession>
    <name>A0A6G0WTV9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_011704</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000148">
        <property type="protein sequence ID" value="KAF0730941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WTV9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009294"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05353">
        <property type="entry name" value="hydroxyacyl-CoA-like_DH_SDR_c-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051687">
        <property type="entry name" value="Peroxisomal_Beta-Oxidation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45024">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45024:SF2">
        <property type="entry name" value="SCP2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="6"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0730941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="301" mass="32187" checksum="19A92EE3CD900D1B" modified="2020-08-12" version="1">MNLANRVAIVTGAGNGLGKAYAMYLAKLGANVVVNDTGGNRHGVGTQTGAADAVVNEIRSLYGKNAAVPNYTTVEHGDEIVKTALNSYGKIDIVVNNAGILRDVTLKNMTEDDWNLVIRVHLNGTMSVTKAAWPHMREQKYGRIVNVSSASGLYGNIGQSNYAAAKMGIAGFTFTTAKEGSRSNIKVNVVAPLAMSRMTQTIESASPKVIKRLQPSFVAPFVGYLCHEDCAVSGNVYEVGAGWVSRVRWQRSKGVVFPPEGMTLETVAANLDGIHNFEDDATYPESLLDSIDACENALKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WUN9</accession>
    <name>A0A6G0WUN9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_011474</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000146">
        <property type="protein sequence ID" value="KAF0731213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WUN9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009810"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0731213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="359" mass="37038" checksum="86235638B98FD4DC" modified="2020-08-12" version="1">MPAETPHAGATPGQQSQAVVAYDELRSTNLAMMDEKEDMSTLQTLLAKKRKLLIGCGVLLVVAIAGVVALVAGGKTSDATTGAALEPTTTPNTTTAAPTTTIAPDTYADVIVGNSVDAAYTPSPEPTTGSALESATIKPNTTNTTDAPITTPAPTPNATTTPEPTPEPTTMTPAPTTTTPAPTTTTPAPTTTTLPPTTLAPTTTAPKFNDNGSGLWGGSIKIVNNIQQNCIYTTKTVTYFPPGYSSHDLTVGASDTIGPFSGKYTLGVQENVFAKCTYAGTCAWEAKSVDNYCYNFNVYKDCTISYNDCPYPAGNPSPAPDGRKRYSISGSVDASGLCVLSVNPTTSGCTGECFCAAKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WVJ9</accession>
    <name>A0A6G0WVJ9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Kinetochore protein Spc24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_011138</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPC24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000141">
        <property type="protein sequence ID" value="KAF0731512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WVJ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007384"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.570">
        <property type="entry name" value="Ncd80 complex, Spc24 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013252">
        <property type="entry name" value="Ndc80_Spc24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08286">
        <property type="entry name" value="Spc24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0137">Centromere</keyword>
    <keyword evidence="1" id="KW-0158">Chromosome</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="1" id="KW-0498">Mitosis</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="71"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU368011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0731512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="213" mass="24844" checksum="BD7A60E8C85599FF" modified="2020-08-12" version="1">MDHDMEESTSAPTAAELSWEEAKGLCEEISAVFDKGLKDGQRLFQIKSKYEGLRTALNDQQKSARQTVTDMMAEIQRIQQYEDERDNSEEMLRRIQDLDRLKHELQHKLHELKEEQLVSEANIENLIAQYDLAQQRYTEECAAREKDIPRLKQTIALYASITGIKWDFASEHIAGNIHVPERKHVESFELKEPHNAFDVANELWRLIDDVHKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WVV3</accession>
    <name>A0A6G0WVV3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_011263</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000141">
        <property type="protein sequence ID" value="KAF0731645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WVV3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002409"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0731645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="347" mass="37910" checksum="7A0B83EC9E8CCD9D" modified="2020-08-12" version="1">MAGSPAPGSESNVILSLSSVKFPAHTDTFRIRISAKRDDVPISIWMSSKQSNLQWETEVTCFDDHKPLTAGYSLPSPMQNALTSCTKRQNSDENNPSEHFQISVKTGPNNQLSLQLALMAFVGFRAEYTFDMVPKTTGPIDALCSQVYAIRESVDEIKARTDEIKRSQEGSTAQALHLSTVQATKSYNDFEWAKKKLPPPRFATLNGDSTEIKIKQSGLYNIQVAGQCNSSSGIVVLKINNLIVAQMGAVQQDNEQSGKYQVHLSHTALLVSGSKLKVSASAVNPCDHPKCAAGRCKKVKISEKATLSLHSVKTTTTTRKVKVINFPIKFSAQSRYLLSSLGEISSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WWD2</accession>
    <name>A0A6G0WWD2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_011097</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000140">
        <property type="protein sequence ID" value="KAF0731796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WWD2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001028"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009316">
        <property type="entry name" value="COG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024603">
        <property type="entry name" value="COG_complex_COG2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024602">
        <property type="entry name" value="COG_su2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12022">
        <property type="entry name" value="COG2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06148">
        <property type="entry name" value="COG2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 2 N-terminal" evidence="10">
        <location>
            <begin position="3"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="COG complex component COG2 C-terminal" evidence="11">
        <location>
            <begin position="385"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="90"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0731796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="716" mass="80539" checksum="4F9CEA74052A0CEA" modified="2020-08-12" version="1">MYCFDASAFDAAEFNATLFLEECQGRNPIAQVHRDLELFMQSLENQMVAIIDKDYAEFLQLSIKLKGVNSSVLSLRTPLSQILERVQAVKESAYILVSKAENQVAELERIQRQKEELQMSISISERLHLVEGLLGLSHEEAEDKSENDTLDEHEGSLLASILAPTEQSILLERAARIVLELQYRIAQAADIPHILAEEPRMALIERTLRERLEAEFATEIVPDNFYAREHVMNATNVDHLLRAYLLLQHPSIPEEMIARLVVQPFLDETMTRGRLDGGHRGSCEGLSSIYSSILSFVERTLGAVLRLSVCQSSISVDILGQSIWKPIHDTMRSKLAEVFTPANPDRFYHTYTTSMSFISSLEQFCTTKASLARFRATVKPFHDGWNVAIYFQLRQNELNQAITTSLGKRPTEDILVRDVAGFAFPVSTQTLNMAVKCWADGTYIASLLPQFARFLLHLLSTYCEYWHDPLGRALLAAKAMTKTSFEDVNHPCLTSCDDVYCLGSDLHRFIHEVNGQVMPAVTARVSVALPDEDAATFVSQLLEDHIKALEAMELQCWDAAIFLVAEECKKVLPALRSIKGQYQMTNKPLPTTASMYVPTIARPLHEFLDKWGACLGSFATTLSTQVLLSNVDMYASLAFELLKSATELEESLRSRKTQRAMVSSALDDTVSDTDKMRRQLWLDMQELARISSTLTVDIAAFPSFQRLHAEVSPKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WXQ6</accession>
    <name>A0A6G0WXQ6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_010603</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000135">
        <property type="protein sequence ID" value="KAF0732314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WXQ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014548"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45942">
        <property type="entry name" value="PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="129"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="168"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="295"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0732314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="330" mass="38182" checksum="F915FFDE2B22C90E" modified="2020-08-12" version="1">MTPAAETPVGDDKSTKAKGDNVQEGEEHEDDLMHPLGIFGPQFQQRETEDLCFSMGMTMKEVQQLIDIFNDIDANCTGLINLREFYFLLDTPQNAYTSAILRFAAHQSDPVKLDIDDFVRIICSFVLLSQTDVIRFCFETFDEDDSGSLSKDEFIHMCESIQIRGEGFFKGNFKKAMEAFDTNHDGLLDLNEFMAINHQFPLVFWPLFHFQQTMQAKTLGSKLWTAIHHRQLKIDAWRRYMQKYLGRAPPLSWQERWCGCILADQRLRLIAAQLYDQDMLRLKLQASRAAAENLPQYKRTEADRKKLNKMAQSSSKNLQTTQRNVQKSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X000</accession>
    <name>A0A6G0X000_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_009922</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000126">
        <property type="protein sequence ID" value="KAF0733100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011234"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009543">
        <property type="entry name" value="VPS13_VAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF93">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25036">
        <property type="entry name" value="VPS13_VAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="881"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="923"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="1319"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="1362"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2744"/>
            <end position="2773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="2762"/>
            <end position="2771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0733100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="2807" mass="312038" checksum="3A43B51E326FF89D" modified="2020-08-12" version="1">MLESLDELTWWCLSWIGSITWYSALIGIVLFVVLGAIGDMVLTTVAQIYLKTYVGSSFRIRWSLLHGTLNVENLSLSPALLDASIAAFFPATVEKADLASFAITIPLLSILYCTVTSDLDAIPTWGILIGGLDFVLNVDPASKWRWRADENKDRFAAAVAEALQARLQLVEAHTMLIKSKLDTLATPPKPAAPGLLGRMTEIIMEKLQVTSLLGRVIDASAQKVDVSLTNVSVVLRPPNAKTSKIHFKWRAVRLCTSQLAHEFEEERAIQLLGIGLAIAPEDTSKGTASSSTYVLNPFDLRIKATYAPIMRGLMKTHKNIGITVDWPHLHLAIEPPQLAVINMILAPMADQSMWIAQAKLADEQQCIEIPDVEQYRKDYGVFTALEQRGMASKVFAVASQKIKESLSWVAWNAGGKKNKWTLPVNEEVLCTTRVEEIERRSLVMDLLGLRRDALKWKIPSYGQELPHVSEKMKAAADLIKFLDTPIEHYYSPSKQSDAPLFDSLVIDFALHHVTIECWSATETQLIEFYVDEVSMRIQMATGVSSMMDVDIVVHSFGLNDLRHSKTNVFPHILGRNPDCTDMIHIDYRVDGKADTTVQCEVANFSFLLITSPLVETMNAFTIEEDEETLIWKEDPLPLPPSPPVIYMAQVESTHNPSMLGGMSLDATVLLKGCEVCLLADPSSYTSHILALTCDMDIKAQSNKMFESLTLTLSDVALQPCKVQMTPDGIDLELPGLRTLLELEGDGVDVEVHYELRTHIPVEAPKRLTASASTATATEGTKRAWGVLRKAVKEGNVPEADEPKTPVASGAGTAISGVFGERKFRLKVSDFALNLSKEDIGLFGAIQMRLGEQLEVSEEHAAAAAAKEARVAEARKLRLEQEQLTRLHHQFDSLDTDGGGSLDHGELMKLVESLVAEMGLTAEETQKCHEKLVKQVDTDHSGDVSFGEFQAALNPVEMPYSLLHQGTVQLTAQEYANPRLKRSIVPRVHALTGQPVHLNDSAALAVFWKKYESQVGVSRTSLHQQAPRVVQEKMIRVFRSYEFAQEAWNRLVNPNLKPTEQSPWVVLPHEIAGQGVALFEKKLTSGGTLDSAVAKATSINTGFTGIDMTQFVQTPVVLKTELHTEFGGFYFRMVDKMLPARTPALEFAVEDVQLHGMLTTKENNVKQTMVEGVLTFNSAIYCKYYNTSARQLEPFIEYYPLQMVVKKEADWDMECLLVSDHHLQMNVTATFVRAVTTTSAAFYDAPINSDEVEREHIKVLKGLCWMYNEVGVPFTYYVQSRHATTVELVSDKVEVDPLKYGICKLLNEEEDLKGAMAENLKEKEMRAAFRAADNDNSGELDADEVREVLRSVMKSYDSLTLAEIDEHVRDFMALADTDNSGLVSWKEFQSALAKTRTVAMRTLSIEVANYEPIHGITLDGLGEEVIVELIPTITEPWIEGDIESMYTTGVAYLNQEVVSVDDLNRGVHLLHLVADIDPRYKWTQSYLATHEPDFCPRLLAIHITVDNTHGMTVTVKTAEYVRNETAKLTEVLLLDENGEPSVLNPRQDNQENERFVSLAPYSNFSVPLPLLEHGFYSIRQVGESAWSNNLPLSVWSGRKTRQDVTLYESIDDQPTTIERLKQGGWALVIGPQLIIVNALPCVVEYVIVQKADVNLNRGSNLSTLATVDDNWFGSVNEVNCRHMTIESGASMQVSGLRLDEPAYMKVRLMAEKDRPVGGWSQPFEVAVNAAMEQYGASSTVSLPAGPSIEFKHSWNKQVPRTMEIYVPYWIQNRSGLDLNFKIPHGQYCTWQQHEKYFGKGFHEIPLLVNAPATKATISVQPYQATPFDYDFQSSLGSEVRKYLPDFKSLKHSQPVDMTVVWTNGEISCGVSECVLGYEVIAAPSQFQLSKIVVLLPRYVVVNQVERPLQFTPLTIAKTLPVDVAKINVVLKPQHTLIVYRFMGKDKQVPALRCRDALLNDMWQEPGPWCPVVPLNLKQATCMWLRGPLGHAPYVEMEVQPSGAKTFVMVKDRTLSPSIRIENRSTQFAIRYVQSGVKHAEEMVLPPMTWHSYAWDNPFHPDLLLKVFVDTSRVPEPVNLMHMTKLNNLTPDGGNVKLHGEVYIDGNTRVLAVGDEPVFHENRRQAEEDIFRDMALDIGLHGVGITIVDAAPREVMNITLDGIRVLSPAHSNSMTYDLHHLQIDDMTPRSMFPVVICPTETGYNSNKKEGWLIEDGETPFFHMVIDSYNDAGMVILDQLFVALGSLDIKLNLDYILYILDVFWAILYPPQTQEEIERAGMTEVNAILTKRLSVPDVASLGQLMYFKKCSIQPYNLNVILNSTPGDSDSGLSKMLGSTAGSIIGGIAHVAPEFSIKGISREDKFLFYDDFLWNTVIYDALVGSCINQWYKVVGSIEVLGDPVGLLHEVTDGLALALRQTKRDFTGKSRHKGEGAVTLVQAVIGAPSNAIGKVSNGVGDLLKKATNFESQEMEREPRHVPEGVFQGGLVLGLSIAHGVSGLVTKPIDGMKEKGFGGFAKGIGQGAAGLVASPFIGAIGALEKLSQSVHNTTHLLDEKHFEGTRRIARKGALKAIEDSPLLADTEVRIEAVSGVPIKSNVKVYVSLYELSPDSPNRLGKLVDTFKTKTKRHVMGEAVLDQSRIVDVTSIDMALVFEVVHKRKPLPKKLLGKLQLTMEQVYELFPAMPKRSKVNSTIKEHLKSRKVHNGSIFDKSLDDKNRRSVPAETGWEAAYHRAASIIDGERESLGSQRSLSSLRSRESLRQSSMSNVSAGSNESEGKIPHIVRTFPLEDADEGSPMLHLSIRYFKTLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X1V7</accession>
    <name>A0A6G0X1V7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_009396</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000119">
        <property type="protein sequence ID" value="KAF0733832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X1V7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009537"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0733832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="177" mass="19477" checksum="29C1AFE78F61522F" modified="2020-08-12" version="1">MWSAAATGGPIRSRRLAAAFPMHPWKNHIEEPCRCGVALALHEFKQDALGRPHCVISTSMNSSKIRPIPQSLMVRPTLHMCLVCGDGPFCGDHIGLHFDLCFEAHCPVSSNAAASTRPLRMKFPSRCHHPHGFKLDNEESNPAATVAAAWDEEHDCAYVNEPSLHYLNPAMNAIGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X1Y5</accession>
    <name>A0A6G0X1Y5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_009420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000119">
        <property type="protein sequence ID" value="KAF0733862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X1Y5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009559"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="54"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0733862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="211" mass="24248" checksum="4695F35332EA7702" modified="2020-08-12" version="1">MQDQQTMNTETLLSMLQQSQEELKIVRATTNEQSEDIAILSSFTDHDGQHKTKMKETEMSVAQLRDQVAAVTSDLRAVKWQLTEKTMTTNQHQRQVAALASELDIAKSRLMKKEEETTQLEDCRWSTTTLDLLNLSRFFIFLHQLQLVQLAGQCCHLTLVLIRGHGFLRQLPLDRPQVARHSSHLVAKLTDSHLGFFHLSLAPWEKLILFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X243</accession>
    <name>A0A6G0X243_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_009448</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000119">
        <property type="protein sequence ID" value="KAF0733891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001451"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033646">
        <property type="entry name" value="CLU-central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF466">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12807">
        <property type="entry name" value="eIF3_p135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="5"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="1066"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="1118"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="1167"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="1219"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="1268"/>
            <end position="1321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0733891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1381" mass="155290" checksum="ED751C913303E97E" modified="2020-08-12" version="1">MSIVATISGYKKNQGLLRPWRSRQFTLLSDGWFLWDKEQAGTRGKCWDLVETVIGPVVTKINPYFTFTVTFEDETTILGFSTETEAQEWNEMMQEIADENAAGRREWTAGFKDALKAEDVLTRRELVLKIKPRDWNKEWQFCLRSQIGDGFSEQVRRMKRMYGLWLQFNQYSLMLVDAILNPEDPEEYELISQPGVVNWWNDPSEPNMSIYSYGPVIFKVAMKHWACYKELKEEMKYLGSFKELYDQFRTIASATIKGENAEKYREVQQLKFPLVSTLEIRDMRVAVFAQPIGDPHPMGLRNANIHSILTNLRFTRPAQVLSALAYNELPIFSSIYRSTVSEDIYLMQIQSPYRNVLRMSLRPLAIAGCFVHEDPTQPIQMLSEDELLSMKEQLEHSKKGLVHYLNMKGIKNKFEILPYFDLLYFSTDIVSTSINSRATSFVGSKVYGDVVFTFNPDNSHLPLHLKEAFVLGSIDAKHYVSMLREPDIASSSVERYETHLMQSLSTKIQEVASCLVTLGDTILEDATLTIQNTEASLESRDIIYVSDCSNLRATLREHGINMCFLPAVLGRLTPAQNGTQTLVMSEIVSRFAKHLLRYRLIRQKEKTRTQIAVEVFNEALRGLTESSSDLSHFWGVDLTIWLTLGPYSSSISIFDNSVLDASAYHKILRENPAPLYMSLFRQLRLTVTGRVIKRLLAYGNTLKLSALKVEDVVSFQKSKLTSEWSNMQHKDLTSFTQQLLQLEKLYQTSLMPTQQSLMRKTTAKKSKGESYLELLRSVDERVSGATEGVSENVEEYGIERSLTANLRKALTSARTSDIHAVRAILIDTHRLIDSMPSHTLIPVGVLITMLFLDILLIENETPRDSNSLIDAYVHAWRWLRLLYRPGNTAQLLIEASSHMMSLVVIVKLRKVLKAHAVQSVPVQKFHAMLLLLIKTMPPWQDLSKLMEPNYWFKKVEQHFLGLQSLYLPKPLMHELQAIPTFDVNEPYWITNGLAFLEGDVMGMSLDVEQRSIAQNQNRDPTLHAFTQNSTLRSIQLSLLRFPLPMTTSIQYVSCGYRHAALITTRGELFTFGYGECGRLGHGDEETVRHPERVRFFDDIPVVHVSCGREHTMVVAEDKRLFGFGWGEAGRLGTGESGKCLEPQVVNLPPVIKVACGREHTLALCESGQLMAFGAGYGGRCGVGTEDDVELPTLVEVDPSIRFVAVDAGECHSAAIDDDGNVYTWGFGGSGALGRGNLENDLVPTVVPLLKAQSIGCGAYHTVAIMLNGSVYGWGDALAGQLGDIAVTLGEMRTTPHKITVSQVSAARVSCGSFTTAILSTAGEVYHWGSPEAGNGAPLNKRDACPMKVEMPNGIEMGTFSCGAYQMIVATQLAKFSFIDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X3D6</accession>
    <name>A0A6G0X3D6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_008870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000114">
        <property type="protein sequence ID" value="KAF0734410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X3D6"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026245819" description="Secreted protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0734410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="71" mass="7790" checksum="06F166DCFB7058C9" modified="2020-08-12" version="1">MLRICLARWLAKSAVVCFGYSSCEDSRARSSVGLITYKKSPWRMASDRTKGTARRSPSGGAGPTSWRSTTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X5Z4</accession>
    <name>A0A6G0X5Z4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_008207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000100">
        <property type="protein sequence ID" value="KAF0735292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X5Z4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005302"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="55"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0735292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="195" mass="21700" checksum="5327C5C2A3801221" modified="2020-08-12" version="1">MVALDAIARTLAQAFLHYPCMKYAFDGMTEAERLEKLTILERTVAVAALNFGGIVETKDGNGALLWLAGKNFPLSLEQSEQSGITELPALLGMTVIQRFASHTREGNNYVVQHAGKTMGWIWVLGVAPESQGKGHGRYLVEKAVADMRAQGMTEFWLVTESEVNVIIYKKLGFQVMHEHVLFSSGIRKWTMKRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X621</accession>
    <name>A0A6G0X621_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_008126</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000098">
        <property type="protein sequence ID" value="KAF0735440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X621"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005914"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF32">
        <property type="entry name" value="AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="4">
        <location>
            <begin position="42"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0735440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="657" mass="71544" checksum="43FD9B505A5A06CD" modified="2020-08-12" version="1">MASTDADTPKPLFAWQVDQEVSLRVTKEGNGALPPQTVIEIFRKRVKASADHVAYYSKKKDGSKTYHGTTFAEYYADCRNFGKSLLSLGFNAFDTVNIIGFNSLEWVTANMGTILAGGVAAGVYTTNNPEACLYISDHSEAKVVVCDGVHQLEKYISIASKLPSLKALVLYNEDAVPQEIACPVPVYTFQDFLTLGKDVDDALLDARMDAQKAGNCCTLIYTSGTTGNPKAVMLSHDNLTWTVEATARQYEAHGIILNQNSNTVSYLPLSHVAAQLFDIYVPLCRGIAIHFAQPDALKGGLGHTLKDARPTFLFAVPRVWEKMMEKMIEVGRDATGVKKTLVDWAKSVGTAKSKLGQYGQSGGTPCGYAIAHALVFSKVRQALGFDRCQAMLSAAAPISMETVNFFAALDIPLFEIFGMSESTGPTSFCTPGAWKMGTVGQPMDGSYMQIVPDSQEVICQGRNTMMGYLKAEDETKQAIDNDGWLHTGDCGKIDADNFCSITGRIKELIITAGGENIPPVLIEDAIKEEIQLLSNVMVIGDRRKFLSAIFTLKVVVDGEGNPSDQLDSSALAIMKQIDSPATTVAQARDCEKVKAYIEKSLKKANARAASRAQQIQKYIILDKDFSIAGDELTATLKLKRRIVLAKYEAEIEAIYAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X694</accession>
    <name>A0A6G0X694_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_008080</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000098">
        <property type="protein sequence ID" value="KAF0735388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X694"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014119"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="75"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="370"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="383"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0735388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="406" mass="45347" checksum="ECA8D3B457A5B014" modified="2020-08-12" version="1">MGTTTSSSQPNGVGETTKPTRRKTPTSLPALLDPFELEVNAMILNDDSALPIPAPVEDDALSRGHQRGRVEDYYKVEATPLGRGHYATVWRGECRQTHQPVAIKKIKRALTDETRVRAEISALRRIQRHPHIVTLLDVFETPREVVLVMELCTGGELFERLASRGPYSEMDCVRHVRHLAEAVAFMHANNIVHRDLKPENILLSTPDDAVATIKIADFGLAKLNTTTMKTKCGTWGYSAPEMMSGGSTAAFGYDAKVDSWSLGTILYILLCGFHPFDPQGNRSDNDMMAAIKQCKYDFEDNAWQGLSAQSKDLIRHLLVLDPTERYSMSDLLRHPWITGQAGVEIPIGPLSPTIHTDLARFHLRSKERMLSYEEDETEERSKQGTSRSSPDFTRSSKDSSENVPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X753</accession>
    <name>A0A6G0X753_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WRKY19-like zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_007853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000093">
        <property type="protein sequence ID" value="KAF0735849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X753"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014390"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056866">
        <property type="entry name" value="Znf_WRKY19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827:SF1">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24906">
        <property type="entry name" value="Zf_WRKY19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WRKY19-like zinc finger" evidence="1">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0735849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="210" mass="23395" checksum="5A1D359EE9E29731" modified="2020-08-12" version="1">MMRCTFKDCANQVHGGLDKCKFHKARKQCCMDGCLNIVYARNLCVRHGGKKKCTAPGCKSNAYGGEFCGQHGGIVSKRFCKFQGCSKQAHARGLCVRHGGGRICTIHDCSHHARENGLCQKHIRRGHHDNDDRLSEASEVSVVLAEQIKVLDVVQPIGFGEIASQPLTSLDQMEFLHFLDEYFDVLPKAYVTVPSAWNTTATENQPRYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X878</accession>
    <name>A0A6G0X878_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Ae201684_007232</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X878"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005852"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0229">DNA integration</keyword>
    <keyword evidence="15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="13" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="14" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="17">
        <location>
            <begin position="380"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF0736209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="468" mass="51927" checksum="B516518CB5B8857C" modified="2020-08-12" version="1">MKSAPSYDELEANIRTEAARRGSEIVAKHREDKRALEGNLADAAETQATQSHLELQRRIEVIEANLARTDSHHARRPQGPRSSNPHANEVCGYCNRRVHKTEKCFLKRKHNAEVEQDKSRTKVPEANMRHGDDADVHLSSEDGPSQAIDHWNWCGAATLEPKVANQVDQGQVDRKLAETEWILDTGATHHMCFVKGMFNDLQPVDSSLANFVGLPDGGKITIEGIGTVKLRVKCSATGNQATIQLNQVLYIARFNRNVLSVPKAYAAGLRFNLDAKPGQVVFSYGDQSIVSADTGGTPLYILRHIPPSPQPVQAEANALMAQPTFDLRHRRLGHLNAHDMKRLLDKDIVRGFKVTRSDLNGWICDACELGKKSKRVKLPSATTPADKCNAKVHSDLTGPIETPAIDGARYVCLFVDRHSGYISCYFLTKKNEFNDLLVQHRALVENKHNLPLVELHSDNGGEFQAPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X8P9</accession>
    <name>A0A6G0X8P9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Thiamine pyrimidine synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_007377</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Responsible for the formation of the pyrimidine heterocycle in the thiamine biosynthesis pathway. Catalyzes the formation of hydroxymethylpyrimidine phosphate (HMP-P) from histidine and pyridoxal phosphate (PLP). The protein uses PLP and the active site histidine to form HMP-P, generating an inactive enzyme. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N(6)-(pyridoxal phosphate)-L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + L-histidyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + 2 Fe(3+) + 4 H2O = L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + (2S)-2-amino-5-hydroxy-4-oxopentanoyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 3-oxopropanoate + 2 Fe(2+) + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:65756"/>
            <dbReference type="Rhea" id="RHEA-COMP:16892"/>
            <dbReference type="Rhea" id="RHEA-COMP:16893"/>
            <dbReference type="Rhea" id="RHEA-COMP:16894"/>
            <dbReference type="Rhea" id="RHEA-COMP:16895"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:33190"/>
            <dbReference type="ChEBI" id="CHEBI:58354"/>
            <dbReference type="ChEBI" id="CHEBI:143915"/>
            <dbReference type="ChEBI" id="CHEBI:157692"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:65757"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NMT1/THI5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X8P9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018556"/>
    <dbReference type="OrthoDB" id="434407at2759"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027939">
        <property type="entry name" value="NMT1/THI5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31528">
        <property type="entry name" value="4-AMINO-5-HYDROXYMETHYL-2-METHYLPYRIMIDINE PHOSPHATE SYNTHASE THI11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31528:SF1">
        <property type="entry name" value="4-AMINO-5-HYDROXYMETHYL-2-METHYLPYRIMIDINE PHOSPHATE SYNTHASE THI11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SsuA/THI5-like" evidence="12">
        <location>
            <begin position="32"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0736357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="354" mass="39123" checksum="599F0F7DE3F15380" modified="2020-08-12" version="1">MLIVSVTRATDTQAIMAPATKKTTFLLNWYANPYHTPIFVAKKRGFYEEEGIDLAIMETTNPSDVTEIVGSGAVNMGLKAMIHILAAKDRGINLTSMGSLLDEPPTGLIFKASQKITKFTDIVGKRVGYIGHFGKVMIDDLAKQAGLAPDSYTTVRVGMNVTDAILRGDIDTGIGFTNFQRLELEELSGEPAGMLRIDECNGLGCCCFCSVMFVASDAFYNANKELIAGFLRATRRAMDITIEYPEQAWEDMCIMNPRLRSTKRTVQVEVDGKQVSVTTGSDVYEKIFQRTLPYFSRTLLNVERDWDKVGNFCKYLHVLENEVDQHSVYSNELVPAMGKPSVDPITPGGVLNLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X9H2</accession>
    <name>A0A6G0X9H2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_007071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000088">
        <property type="protein sequence ID" value="KAF0736621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X9H2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018294"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0736621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="229" mass="25694" checksum="17AA83A9075D537D" modified="2020-08-12" version="1">MDSDAEAEEIASDDEIQAADEDQAYSVDFEEDIQPSPAKPSAKPAPAAFPAKQTPPPPVKQAPPPPQPVNQPTKQPVEDEPEYDDDFENEDDGGYGDASFENESRSSSPRHHVNLSVPTRPPSPPRTYDKKPEPPPSPRPLARIEEEPIDNAKARETNRYIRQLEVQLVDENDQLKFQHAQLLRANSDLKNELRKNEQTNDASSTSFCSRRQNKLSLTSRQSTLRWTQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XAK0</accession>
    <name>A0A6G0XAK0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_006911</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000085">
        <property type="protein sequence ID" value="KAF0737107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XAK0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021113"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF458">
        <property type="entry name" value="SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="407"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="9">
        <location>
            <begin position="46"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0737107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="479" mass="52555" checksum="A817ACB901E80C49" modified="2020-08-12" version="1">MSGKKSPNLSASFKSPGIKSPNLFQYEAEKHSYEFFFPSPHSKARQTTVKSAVMNLVTTLIGGGVLLLPFTVAKSGIVLGCIMMLFCGVASSFTSYILVSCSRRSGAQSYEEIAKNAFGKRMQIATMVLLILLIFLAFVGYLILLRDISGSLASQFILRRPLSVADENLVAVVLVAIVSPLLFLRSMHSLRHTSIIGLSTVGLFAFGIVFRGVEKVLDNRFDSSKLVLVADSLDGPMYALPIIISSFLCHFNVLPVYGELQKPTRRRLKKIVTITVFSTAIFYMILGTFGYIYAFDRPGGVQGDILNNFGQADVLMNVGRAGILLTICMSLPLLILPTRKTIYRLCLLVYEKFAKVEATMQETQPLLESSELSDQTEKPMPLTPHVVITLIILGLAFYLAFSLPGVAVVWNIMGSTVGILISYVLPCVCYLRIRSEKPGSDWRKIGAWVLLAISGTICVVCSIQAFEKLGGMLYTVFVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XBN1</accession>
    <name>A0A6G0XBN1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RCC1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_006702</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XBN1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011109"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="141"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="RCC1-like" evidence="5">
        <location>
            <begin position="143"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="197"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="249"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="300"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="353"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="405"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="457"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="553"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="656"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="585"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="682"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="707"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0737547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="728" mass="79530" checksum="39C685FED7BF04FB" modified="2020-08-12" version="1">MHRRVNRAAGRPVRPRTAKIAVPHGVEGSSSSPLTLKPSVKNLRLRRGGDTTYTLCVGHSPLITQKVVVTIAIPDKVTGITLSPTEARRSWTKSSSSVDRFRSRADTAELFRFTIVHTAHTVDSMTCMMSVNVQIVAKQPRFVFCFGSGENGRLGIAHRSDKRDANAFTPTPLGSKWLVPAQVACGKAHTAIIDANAHLYCCGRGSEGQLGQIHQESVKVATVVPKLMNMQVTHVSCGANHTLCIVNQTWGYAWGDNSAGQLGLNLKAKHQLTPSRIHGLSHLRTFVCGGNHSFAITTMGDVLVAGCNIAGQLGLDDTTRRPAFTLNPHLHHVESLASGVYHAIAHTTSPHGGGVFVWGCGDNGRLGLGHHESASTPQPLGEFDGVHVRQIAAGGSHTALVTETGGLWMWGANAYGQLGDGLHTDRLAPHRLRMFHGKVVQTITLGEWHSVALTDDGSIYAWGFGEEGQLGLGDDRNTSFPLEVTALSGTSPISVSCGATHTVIITAQEVSSRAKPEQCQNNEKKALGMEQRRLLLRKSMRWKQMSSMSVVTEETSYPKESFEPKPPPAAATPRKLPKRPQTARPHREEPSARGCDHVVPWRERPLTSRTSVRTALRQEFHALSLLKRQISTASRPLVCEALAKKEETLKAQARVDPFEALVSPPTTTQTPRRLEPRRRPQTAPTSRNQQPEMALFPREESWSNLLADDDDDEPFDSVLEEEMNLGWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XBQ4</accession>
    <name>A0A6G0XBQ4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <ecNumber evidence="7">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_006677</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="7"/>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XBQ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015562"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019796">
        <property type="entry name" value="G6P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00871">
        <property type="entry name" value="zwf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429:SF0">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000110">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00069">
        <property type="entry name" value="G6P_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 7" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="4 7" id="KW-0521">NADP</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase NAD-binding" evidence="8">
        <location>
            <begin position="19"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase C-terminal" evidence="9">
        <location>
            <begin position="197"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0737520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="503" mass="56572" checksum="C1EF5E6D82F876D9" modified="2020-08-12" version="1">MATSKAHTEYMKQSLTILVVGASGDLAKKKTYPSLLELFVHNFLPKHTIICGYARSHKTDDEFRAFLSPFLKTKDERKKLQFLQMCTYRQGGYDSVADVGKVSTELRALEKSTGLSVHNRLFYFAIPPNVFVPAGSAIKGAALSTTGWNRLIVEKPFGHDLESCVDLCQAMGALYSEDEIYRIDHYLGKEMVQNLLLLRFSNSTLEPMWNRNHISSVTITFKEDIGTMGRGGYFDSYGIIRDVMQNHLLQVLSLVAMEPPVRCVGDNHANFVRDEKVKVLRCIEPVQLDDVVLGQYISNGKEPGYLDDKTVPKGSKAPTFCSLVLRVNNSRWEGVPFIMKAGKALDERKAEVRIQFKEAPGAAQMFPNANIPRNALVLRLQPNEAVYLKTNVKSPGLRTVPMASELDLSYAARYADTHMPDAYTRLLLDVLRGYQSMFVRDDELIAAWSIFTPLLQEIDAKQIKPLPYVFGSRGPAESDALTAKHGFIYHQGDYKWQPTKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XC91</accession>
    <name>A0A6G0XC91_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helicase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_006263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000081">
        <property type="protein sequence ID" value="KAF0737769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XC91"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002369"/>
    <dbReference type="OrthoDB" id="62632at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005114">
        <property type="entry name" value="Helicase_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37066">
        <property type="entry name" value="HELICASE-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37066:SF1">
        <property type="entry name" value="LNS2_PITP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03457">
        <property type="entry name" value="HA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase-associated" evidence="1">
        <location>
            <begin position="52"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="1">
        <location>
            <begin position="126"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0737769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="197" mass="23326" checksum="4EC5B7F993FC09A0" modified="2020-08-12" version="1">MPQYIQRQNRRRDNRLCISFLLNQSTTWATEKEATFIDNHDEVSASQRIKSSWFDKFIALETFKEIHGHLLVPRTFKVPSNDPQWPAPTWKMHLGVLVNNLRTRNQPKDRRKQLDRMGFVWDTMEFHWQINLLALRTYKEKFGHLRVPQSFKVPKEEGGWPEETHGIKLGWVATTLRRNRGSMAALRETALDRLGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XDM5</accession>
    <name>A0A6G0XDM5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_006187</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endomembrane system</location>
            <topology evidence="10">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MNN1/MNT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0738212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XDM5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003216"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046354">
        <property type="term" value="P:mannan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646:SF1">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="487"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0738212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="523" mass="58885" checksum="5DFC373EC1290023" modified="2020-08-12" version="1">MRWSSQCSVLPAAVIIALVLVWSLWPPPRVLPPLELPHDRVPGVWTDETFECVGWQAVQGCNGSASAPRDPQKDQACDFPIKAGMAGYCLVRNRTSGQTFRVMRSGCKSVRPIAEYTCNQARQFTDFAHKAATYEPSEQLQLKQDGSRGIVQSVYEPAIPGVYAIIKLLRQQGCVLPIELFYMKHEMNLDNPVLKHLLATDTSITLREIPLWLDKFATKPYAIFHSAFDQLLFLDCDNFPTRDPTYLFDHPAFVSTGAIFWPDYWTPANSMFGMNHQSLLWELFDMPPFGFFEQESGQLLIDRTKSIDALTKLAYYNDRIDVWGPLRVLHGDKDLWRLAWHNTSTPYHFVETPPAIGGMYDFGVFCGVAMLQHTPLNASDVAFVHANTMKIHGDPAQVPVWTHVQSFAADDPRWYVVSNEGEWFFGTPSCWGLNFLAKSTVKSIAKTNIGGSLELDVLKLARDAGRMMNRPPNPSRVPSMREFLDEWFSLVALVAAIFIVVAVATVLQQRVLTDGACSIFKQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XEH9</accession>
    <name>A0A6G0XEH9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_005521</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000071">
        <property type="protein sequence ID" value="KAF0738593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XEH9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004694"/>
    <dbReference type="OrthoDB" id="44467at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071913">
        <property type="term" value="F:citrate secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF4">
        <property type="entry name" value="TRICARBOXYLATE TRANSPORT PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="91"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="191"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0738593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="30273" checksum="CA11A375900A36BC" modified="2020-08-12" version="1">MSKEVAPTGSLSSGEHLAIGALSGIFELLCQQPLLYIKNCIQQNHPISFRPSVLYRGVGIMSASMAPVTGVQFAVDGTLSSYLYKTNNVTPSDATRIGTAAFAGACSSFLSSPAELVMTLQQRTGHSLVQTTSDVIQKHGFTRLFVGIPLTMTREIVWCASFLALGTVLSEKLHDGLPGTFGDRNTASISQRTATSLIGSVGAGLVAVFATQPVDTVKTIVQGKGLEATPASAVAEFRTLFNGGGIKALYKGTIPRGVRLVGAVFILSETKKFLEDQAYKLKGLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XEX0</accession>
    <name>A0A6G0XEX0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_005552</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000071">
        <property type="protein sequence ID" value="KAF0738624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XEX0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014467"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0738624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="241" mass="27740" checksum="5F22481FA1D8B9C2" modified="2020-08-12" version="1">MKRTQRAWLNLYMATHDTDKAYNNLMQLIQRFCERHGFTKQKPHKMKRNQEELEELRDQFAEVFHRRYAAYGSKDVYNVDETAVYFEMPPRTIWSIRGSNLALSAGEKHSMQMTAVLTVRGDGVKLPVLFIMRGVPGGLIENREFSTIPSDHYYVVQKNAWMDSAVWSFYLRHVLMEEIDTPSASLSIISTVTSPLSLDVLLSGSLGQRFVPFHPTRLLISNPLMLGSWRLSRVVCVTCGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XF26</accession>
    <name>A0A6G0XF26_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_005399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000070">
        <property type="protein sequence ID" value="KAF0738787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XF26"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017552"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0738787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="193" mass="21331" checksum="A77212A048DAC9C5" modified="2020-08-12" version="1">MIALPAIKEASIEAKPVNGLADDTTSPKSVTLGDVSHALAKLVTDQTLRIAKYRTRPATAAPGNVDRALTKLGVTEETLRIEKLMKKLGVCDNDLQAYDDLQRHSAVVDLSREKMTKEELLCGYSKKQMQRVKAIKSLGTTEEEIEDDHSQRVSQLGIQIEPPKESFSSLPRRPSPRRSSIIGLLPSKWTTPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XF72</accession>
    <name>A0A6G0XF72_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_005468</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000070">
        <property type="protein sequence ID" value="KAF0738858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XF72"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003281"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.90.10">
        <property type="entry name" value="Tubby Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000007">
        <property type="entry name" value="Tubby_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01167">
        <property type="entry name" value="Tub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01573">
        <property type="entry name" value="SUPERTUBBY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="Tubby C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="217"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="17"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0738858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="604" mass="67674" checksum="D2AD5FFF8693CFE1" modified="2020-08-12" version="1">MAAKQSDDLVFDLEDLSDSSDSDWVDVASSPINRQSKRPKTSTSASDKQSNTTDLNSPSVSDEEYVESSIVRDLYGPSVKKLSKEFTDKVTLVDDAQTQKSNELFEASGECFEGISNAIDKQTSPAIKTEPLDDLYSDLDILAIRNKLESSLEMNLSQEFTWKVSLDQPIKPSIEDKGSMISVSERDNAQPKIHNDVKMMNDYTEKKMDVASLKEECSLCEDLVDILTRLPACDHGFCLTCMFRWVFSIKDCPICLANAPVKISYTCCYECSSFVDSDMTSTHFQFCGSNPATKKSPEKIFLDQLIASSSLTCRGFLMEFIMAPLPLEVRTIRCSIESRGRGFRLMLGKTFLCAAVQYPEIDRRVCHSFYRGDLDECKVARMKRNAIGSEYTIQNVQDNTSLGAVQYTVSYQGTGRQIVMALPSVTKFGDSGWTIDTRRDTMLDVLDEYGAPDSIHLLNKPRPPRQEFSYDDYGNPIFSDDGIKTPPVTADFNYETHDEELQRDLALVAAMISASQDTPPTCATSNESVSKSSCFEMVTVENMDTSVLEFGRGQLHHEDYMSEYYLEFSHPLSPLQAFAIALSSMDSSLGEDDVHYFVVKIFHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XFM0</accession>
    <name>A0A6G0XFM0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_005322</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000068">
        <property type="protein sequence ID" value="KAF0738953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XFM0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003505"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000104">
        <property type="entry name" value="Transcriptional repressor protein YY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF139">
        <property type="entry name" value="PAIR-RULE PROTEIN ODD-PAIRED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="94"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="124"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="154"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="173"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0738953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="319" mass="35512" checksum="D9FD7A54DA00F491" modified="2020-08-12" version="1">MPAFYGANLRLHHVPLHAAPALDTTHACTEPGCNHYFDDAQSLKDHMTQHTWGPHTIQTAPDGTKTFVCLNCGKGVSDRKVLRKHLLTHQEKRFLCSFDGCDKRFYERAKLKRHMLVHTGEKSFMCTFEGCGKQFAYKANLKTHLRTHTGLKPFACLVPGCNRTFAQASNRNSHMQTHNRSMPLPPSPVAKAKPQHAHRGSGWPEAKEMMSLMDHVDSVIGHSIMPMTAYKVPVMALPIQELLDGGAASHQQQHQQQQPPQQQQYIATPILSKKVRSKGLDGTIPPLDLSTDGLKSSDLYSMLPTPGSFIDNAVFSFEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XFQ7</accession>
    <name>A0A6G0XFQ7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_005300</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000068">
        <property type="protein sequence ID" value="KAF0738929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XFQ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006807"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF214">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="333"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="404"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="432"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0738929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="677" mass="75900" checksum="A7B203B6AB281A4A" modified="2020-08-12" version="1">MTLALLAAAQVNAASCPYTNLPASVTNVLVADKSLCPAPNATCIVTKACRYVGWQNVTDWAGVEKQPANATWQAIGDLRGWQPSTRNEWLTLNGQGRTIDMSLFQLNDIVTSLYFNNMPWVLPSNFTWPSTATQLWFSYIPLGTLPPLPDKLQRLFAFQSKLKTLDDLRKLPPTLTWLQLAGNSYTEWTNLDFSALTHLEPWSNKNLTRIENVTFSSRLMMLDVHDMNISSWIMTTDTFNALNRLQPYYFGLDKEKDDGWGYIGYTYANLTIDSNATECASKRGTIQELWGTNKTARRKPYDQSVFRVCVLSSLSDNPPTSQTTTTTTESSTLSSGVIVGIAAGGAALFGILVFMVMRRRQVRAEKVLKHVQEMYHSTEELPSNDVTGLDMKQLTMCRLDESRLTLHRKLGSGAFADVWLGTYQGESVAVKKIHANRVTLCQLQSFVEEITLMATFDSPYIVKLIGAAWTRPSDVKGVMELMDGGDLKDCLDHNTPVDFPWNDKYMHIHSIVHGLVYLHSLNIIHRDLKSRNVLLDSKKSTKLTDFGVSKEDMQATMTVGVGTFRWMAPEVIQDKSYTTSADIYSFGVILSEFDTHRIPYEDLTNPSTGLPIGDSAILVSVVQGEIKPTFTRDCPPWIYDMAMQCLAHNPDDRPTAMQLAHIIRTKLKEMSTGLFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XH42</accession>
    <name>A0A6G0XH42_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Cysteine dioxygenase</fullName>
            <ecNumber evidence="2 9">1.13.11.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_004757</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-cysteine + O2 = 3-sulfino-L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:61085"/>
            <dbReference type="EC" id="1.13.11.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="9">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the cysteine dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.20" evidence="2 9"/>
    <dbReference type="EMBL" id="VJMJ01000063">
        <property type="protein sequence ID" value="KAF0739577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XH42"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017006"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017172">
        <property type="term" value="F:cysteine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019448">
        <property type="term" value="P:L-cysteine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10548">
        <property type="entry name" value="cupin_CDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010300">
        <property type="entry name" value="CDO_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12918">
        <property type="entry name" value="CYSTEINE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12918:SF1">
        <property type="entry name" value="CYSTEINE DIOXYGENASE TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05995">
        <property type="entry name" value="CDO_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="3 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0883">Thioether bond</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="cross-link" description="3'-(S-cysteinyl)-tyrosine (Cys-Tyr)" evidence="7">
        <location>
            <begin position="185"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR610300-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR610300-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0739577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="277" mass="30790" checksum="E9D7DD8C1B899BE4" modified="2020-08-12" version="1">MHEPLAVSSTVPGSPVLPEKADVKYRVSKSRLPRGKLSAATLARQNLLHPSAELPSSHPANRIKAHRRRVQVKVPRACQDAIAKTSSKSEPAKKQLSLQKLVRVLEDDIQLHVGPMTEQKKKAIEEALAAFDANPTALEPFIRFNPDKNYTRNLVATDDKSYSLIVLCWNKGKYSPIHDHPSDGCWIRHIQGAVNEVRYWNDGDKLVETANMLITEGVTYMNDSLGLHKVGNPSDDVDAVTLHLYAPPISQCRLWHDPSNAARSTSTVCSYDTQFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XHX1</accession>
    <name>A0A6G0XHX1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_004587</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000058">
        <property type="protein sequence ID" value="KAF0739886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XHX1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011401"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021150">
        <property type="entry name" value="Ubiq_cyt_c_chap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007129">
        <property type="entry name" value="Ubiqinol_cyt_c_chaperone_CPB3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12184">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX ASSEMBLY FACTOR 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12184:SF1">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME-C REDUCTASE COMPLEX ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03981">
        <property type="entry name" value="Ubiq_cyt_C_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="276"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0739886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="306" mass="35037" checksum="7D2CF60541BF81C5" modified="2020-08-12" version="1">MLAVTRRSLRRYAPAVQLTAVMAFSTKVPTQIPPPGPSSGIFNTNFDVTQPEHKQRIERWKWLLDLLGYYNEDARISSKSTLLYHSCVNQAAHPSFYRALDLPTDFRAQQALLMVHVWIVHRRLISSKSSGKNDPGKILQEALFDRLWEDTVFRIRHQNVSELTVNKHLGEVQQRCFSQCVAFDQHFTAGGSKTVLNDAISRHVLNVEPNVKPKQAALMASYVLRELKNVQKARFEDLEAGDISWGAPLESPTSTLPSESKDDYDFDLVGQKYGNWRSALDVRGKRYFWNLTTRISAWEKPPKEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XHZ1</accession>
    <name>A0A6G0XHZ1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Calpain catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_004630</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000061">
        <property type="protein sequence ID" value="KAF0739822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010287"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.380">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022682">
        <property type="entry name" value="Calpain_domain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022683">
        <property type="entry name" value="Calpain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036213">
        <property type="entry name" value="Calpain_III_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051297">
        <property type="entry name" value="PalB/RIM13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46143">
        <property type="entry name" value="CALPAIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46143:SF1">
        <property type="entry name" value="CALPAIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01067">
        <property type="entry name" value="Calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00720">
        <property type="entry name" value="calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49758">
        <property type="entry name" value="Calpain large subunit, middle domain (domain III)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="6">
        <location>
            <begin position="259"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <feature type="active site" evidence="4 5">
        <location>
            <position position="486"/>
        </location>
    </feature>
    <feature type="active site" evidence="4 5">
        <location>
            <position position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0739822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1029" mass="116574" checksum="B548EA6EAABBA8E2" modified="2020-08-12" version="1">MNRVNDLYEEAFQAAEAGIAAEEKNEVDVAIQSFEIAVRIFSRLAIVESLSKRTLLEEQIADFRQRIAKLQERDAPTVDASETNVPPIAQSRSVEPGGDTRVQAAERLEQEAQALVDQGFTMKSFVVEKYMLAADEYMKILKDASLTDDFRQRIRSKVEDIIEKVMFLKEEQERENELDQLMEEELYDESEKIILRERETICQPVQRQSTVRENPNRMNKLPDQDDSVVGKYTTEELDVLRNSSVINGRLFQPWLSSDIHERFDSTEQYVXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVVTDCSFVASLCITAAYEMRFHKQLITKIIYPQDANGRPIVNPGGKYVVKLWANGVPRKVVVDDFLPLGYSGSLLCSCTTTPNELWVSIIEKAYLKVNGGYDFPGSNSGIDLFALTGWIPESISFMEQDTTNGDIIWQRLISAHNFGDCLITVATGDMTKEEAKRVGLVPSHAYAVLNVVETSNHLRLLQVKNPWNRKRWRGPYGIDDTERWTPALREELGFDLDYARQAKDDGLFWIDFPSIQRHFSALFLNWNPELFRYRFTLHKHWPLEVGPQNDTYNLGYNPQFKLTFPNAQRRNKACSVWILLSRHVTSVESPETTQQFLTLHVYKQDQRVYYPNDAFSRGTYSNNPHTLTCLDIALQENESPSFILVASQYEKFSSLDYTLSVFSTDEPFELTNAPDPPPHRINLVDEWSASTAGGCPRYSTFLTNPQYQLVVQEQISVILLTLEAPISFPINLRLMRDGQRVDSVSKKRLIALSGQYRPGFCYIECKDLPVGEYTIIPSTFEPDCVGKFSLQLAASSASYQVYALPPEGYGMIESKCSGKWNSSSGTAVGCSNYGQYLLNPQYLLHVPTKCRTFFRLRPFGYSGSAPSVNISLYRCTPTGQITDPNVNPTTAFITSSKGFYTNGACGVRTPLAHIPPGDYVATWQSHRQGCDENKTPLLCSLIVAEQRDLLVKLKIDGTTASMSTLKCFAPLWHDHLADIVIKIRLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XIR1</accession>
    <name>A0A6G0XIR1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_004378</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000054">
        <property type="protein sequence ID" value="KAF0740140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XIR1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003171"/>
    <dbReference type="OrthoDB" id="58663at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0740140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="130" mass="15089" checksum="CDA0B28C12AE00DF" modified="2020-08-12" version="1">MEIAQDVRELLVGSPTEQQLLEDMQNYHLQYCNFQQNLATQVAELDMGPESRIFYYQLQQSMYKDWTAAITDCAFKSSTCNTKTLEEKLATYEKVVACTLGEDGDASSLIKDPTMEQWIHKYEDHRKKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJD6</accession>
    <name>A0A6G0XJD6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_004271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000053">
        <property type="protein sequence ID" value="KAF0740270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJD6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019938"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0740270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="251" mass="27459" checksum="C3FA740F48C720AA" modified="2020-08-12" version="1">MMNNQRATRSKRKTRIVSHNATTLIWKIDGCQLHPKRPRSPVNTTKLASPTESSTPPTESSTPRNGSTRNPSASLLFGSLTALPLALQPAVAIYSSTKVSTPLTWTEKVSSRDILSQSKLPQVTTATTDDGLLLKKTFKTQVPLTGARPFGNLTVDVEVVQDDASDTYYCLTKWYGQSGVGHYELDGPCSLTEAHDVFTGMSPFNEKFNTFWSPSKRMAAMPVEGSLRFVRGYFIGKEKGAPTVIPTQVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJX8</accession>
    <name>A0A6G0XJX8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CBM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_003966</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000048">
        <property type="protein sequence ID" value="KAF0740589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJX8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010244"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026072153" description="CBM1 domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0740589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="24662" checksum="C08D1A894433B3F1" modified="2020-08-12" version="1">MKVAVLLAVLAAAVVARNEPTCAEAFDTCAGNQPCCNGLKCHVFRDGVAQCLEHDPKPKAKDAEESCTNVSVLGDATFCVRGVACGDNGDVCPKKGDVAVGDCVSTLKSYVEKAKCVAPSDAVCQKTPQGPRSCMFGAVQATNSTTNSTLNSTGTISFPNGTSKCSTNWSQCNGQNWPLGVCCEDPKFTCNKKNDYLSLCEPKDFKRENSGDGPENEAGDCDEGRGEAHTDPSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XK10</accession>
    <name>A0A6G0XK10_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="8">3.4.21.92</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_004069</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the peptidase S14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="8"/>
    <dbReference type="EMBL" id="VJMJ01000051">
        <property type="protein sequence ID" value="KAF0740523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XK10"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013614"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013615"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009368">
        <property type="term" value="C:endopeptidase Clp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000001">
        <property type="entry name" value="ATP-dependent Clp protease proteolytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018215">
        <property type="entry name" value="ClpP_Ser_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001368">
        <property type="entry name" value="PRK00277.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009205">
        <property type="entry name" value="PRK12553.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381:SF11">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00381">
        <property type="entry name" value="CLP_PROTEASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 8" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="235"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0740523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="606" mass="67815" checksum="7065928E16520D42" modified="2020-08-12" version="1">MLRSALARGFHGSSFMGVVPMVLEQSPRGERVYDIYSRLLKERIIFLNGPVNDHMASLTTAQLLFLESEHPEKDIYMYINSPGGAVTAGLAIYDTMQYVQPRVRTLCIGQAASMGALLLAGGEAGCRSALPNARIMIHQPSGGAQGMASDIAIQAEEILQLRNRLNRLFAQHTSKDLSLIEQAMDRDKFMDPEGAIEFGLIDSILRQRPKTAPPASTCHFQTCPRAKSMPGDESLTVFVRDFPSHTTDGDFKRFFADCGRIGKIDIKADPGRARYAFVDFDDLSSSRRAVAKDRTMFLNSRVTVNYSKKKPYMHSTPRVTPPPMVSPPPLTPPRAMTPLPPTIVRTPATSTPLSDSDPTSQWLFSSTQSEFTTPSYREGISADLERQLRHTTSWYITDLQKDLKLPLIAAVSAQMYMNRFFMLHSFSAHDRFLVASACLFLSAKVNECTVKLTELTERSLMLVDHSTSAPSPNDIEHVKKMIRQYEVVLLNTLSYYVVVPQPFLALGNLVDQALTQVDFDREQIMLIAHWFLTDAVSGTLALQLTMEELAAGALYLSCRAHHLDSWVESSTFFSHVRIDFVIAQFLNMYATHKSRFPPQLQALFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XKS1</accession>
    <name>A0A6G0XKS1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chorismate mutase</fullName>
            <ecNumber evidence="3">5.4.99.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_003820</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; prephenate biosynthesis; prephenate from chorismate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.5" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000042">
        <property type="protein sequence ID" value="KAF0740935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XKS1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011569"/>
    <dbReference type="UniPathway" id="UPA00120">
        <property type="reaction ID" value="UER00203"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04905">
        <property type="entry name" value="ACT_CM-PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.590.10">
        <property type="entry name" value="Chorismate mutase, AroQ class superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008238">
        <property type="entry name" value="Chorismate_mutase_AroQ_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037039">
        <property type="entry name" value="CM_AroQ_sf_eucaryotic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002701">
        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01802">
        <property type="entry name" value="CM_pl-yst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21145">
        <property type="entry name" value="CHORISMATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21145:SF12">
        <property type="entry name" value="CHORISMATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="Chorismate mutase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51169">
        <property type="entry name" value="CHORISMATE_MUT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51171">
        <property type="entry name" value="PREPHENATE_DEHYDR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate dehydratase" evidence="8">
        <location>
            <begin position="262"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0740935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="543" mass="59368" checksum="9C447B2E322D8781" modified="2020-08-12" version="1">MATKVLLDDFRNDLIRQEETIIFALIERAQFVHNRAIYRKREEASDALLSFKGKYHSFQGSFLDFMLTETERLHALNRRYTSPDEHAFFPAFLPDPILPPLDYPPVLIPNKININDQVMNVYLEKLLPNITVDDDDHTTYGSTANADIAALQALSKRIHFGKFIAEAKFQAETERYTELIRNNDADGIMDALTNLAVEDKVAMRVRLKASTYGQDVEGSASSNTGHCKIDPQVISDLYRDFVMPLTKQVQVAYLLQRLHHPSVSFVGPVGSFAHAAAIAHFGAETQRNMEPVASLSDVFASVVARQTAYGIVAFEDAQTGIAKEAQHLLISSGLQICAETVLERHLLFAGSPSSTGGEIETIYVPVSADTAFGLIIDRVWSSAKVVQVASIDEAARCASHQPKSIALTTSDVAHAVGLVVVEPSVPLSTISRPPPALSVRFIVVGRSSSAATGKDKTCLCLNVKHEVGSLLSALQVFKDHGVNLTALESLQRNAVGGEFGFYVELDGHRNDTNVQAALEALRPTTQEVRFLGSFPVHGPPHVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XKS9</accession>
    <name>A0A6G0XKS9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_003811</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000042">
        <property type="protein sequence ID" value="KAF0740924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XKS9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011560"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08204">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045258">
        <property type="entry name" value="ACAP1/2/3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180:SF160">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN EFFECTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180">
        <property type="entry name" value="CENTAURIN/ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16746">
        <property type="entry name" value="BAR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="386"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Arf-GAP" evidence="8">
        <location>
            <begin position="495"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="653"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0740924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="712" mass="78994" checksum="C3FA1D70FD76BD66" modified="2020-08-12" version="1">MQPKRANQRLDRMADSKKEAAPTHEGCQCPRVAQLEEEVQALQSQLFRYRRKYGNLDVLEQRNSLKPVVTTKADPTPRLSLDDGSSTLISSTVGKHVVLDYVADSPMFRKSLEGLEESTSGLRGFLKELIVRTKDFVAAGKAMGAKEITLAEIYSTKYSRTLFTSCYEELGDLSTILNDFHDTLAQIQSSRESMLLSIDALLHKPLEAFVEEELKMASDLRKDVTKFGDEYEAVLGKSLSKQPSFRISDADVQATAGEEALPDVDKAVTAARCKFELARFDCVRYFNALDAKKKFVLVEALNSTLYSYLGHFHACHDLVHGIEPALRARQAALQTAREQFTRDEAMYAAQRDLLESRLSAYPTHVALPVEVISATTAQSRESALFPAEKQGYLIVRSGLFKSWKRVWFQIHAGKLYEMRKDMELSLVCDLMISKVRPCPRNLPYSFEVLDHNQTKQVLQATSESDMQSWIDAAQASTERLLGQQSHPTAVHPDMADAVQKLQAANPTCADCGLSPAEWVSINLGAFLCIECSGIHRSLGVHVSKVRSLVLDSWDMTLLELLQTWLGNDSVNAVWEATIAPGWTKPDGATATRAEKEKYIRAKYAFRGFSEHTTLSQDALFAEFYKAAARGSVRDLAYGLAHGVEINQQTDDAKRETALHAAAARGHMLACEFLLQNGASLSTGDAAGQLPSDAAKLGGFESLKLHLLTRLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XKU8</accession>
    <name>A0A6G0XKU8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Polycystin cation channel PKD1/PKD2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_003623</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000041">
        <property type="protein sequence ID" value="KAF0741051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XKU8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005655"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013122">
        <property type="entry name" value="PKD1_2_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051223">
        <property type="entry name" value="Polycystin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877:SF183">
        <property type="entry name" value="AT14535P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877">
        <property type="entry name" value="POLYCYSTIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08016">
        <property type="entry name" value="PKD_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="416"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="477"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Polycystin cation channel PKD1/PKD2" evidence="6">
        <location>
            <begin position="279"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0741051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="622" mass="69432" checksum="BC72CAF45CAF8198" modified="2020-08-12" version="1">MASNPSTVTTPSINEILQEMKHMNDDDIKLSFPEAVHALKARAELRLHFVYLPIPMAFFILFAWTALVHVPIQHMFPAELGLETTLVSMGTDAITPNTTMKFKNIQTQADVFAWLLDTFVPSVFVTTDYNGNNFTDAILLRRIDGFNKILGAVEFKTTRASPMRCDADKHLATLFPTCHDFLHPVDMEPVYIDATVDAATASLILQAKQISGTWINTSTTSLIVNVATFNGELNVLCITSLKILFQNGGAIDTQFTMSAVPSDPYHGHWSGGPIALDAFVGLLFVLTLAKEFYLIYRSIRDKTLISVVWDAWRIIEWASLGFVALFYILWAFLCVNIYDKDIVTHLKALDGGTNHDITTLETLMTKLTYMGRVMVSIRLSAMTALFLLVARIMGAVRFHPHLNLVTATLTASLHSLGSFSLIFFTCLAAFVTSGVVLFGERLVQFSTIGRATVTVINMLFGQFDLSAILEVDYHIGVVWYWCAMIILFLMLFNMLLAIVLAAFDDVRSRSRADRNVFEEFFIIAKEVLHVTTVSDKFKTGVSDGTLHRLDPRAVAEFLRIKESHAREFLREMKILSRAGADLSGEAINVDQGRIDNQLAVEDRLSKIEDLLAKVASKLDNCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XLD6</accession>
    <name>A0A6G0XLD6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_003536</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000038">
        <property type="protein sequence ID" value="KAF0741247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XLD6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015722"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="108"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="141"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0741247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="302" mass="33268" checksum="53E522E58F9E1BC5" modified="2020-08-12" version="1">MGAAFSDYFTSPVDVSDGYYEDADPYVIIHHACAKGKHHVASMYFKKGGDPNERCFEDDDVYERDDTPMICAARGYPSEGIRGDQKKHILTLQIILLYGGDVNLYNKLHQTALYIAVTRGYVNIALWLLENGANPNICDSVGVSPLLCAARAGRVDLVALLLEYKADVQPPTRASTCLHFPTLASELKSFDPSIQSLLIEAGIPHDFLPNTKSRRSVASVAMMDALQGQLRALPPRSATPVVVAQPIDPFSREFKSSVVETKVVKPKSDTPSRSSVVDLNKCRSGGKWVKKREVSGRVHKYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XM53</accession>
    <name>A0A6G0XM53_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_003225</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000036">
        <property type="protein sequence ID" value="KAF0741542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XM53"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016552"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="59"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0741542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="247" mass="28126" checksum="C2F793E16AA33E46" modified="2020-08-12" version="1">MMGLVKSVLVSQLVTQVHMKNQRESGLSFANHPEVLYATDVNDTSLGSNINGYKPEGSVAMPGRYIDVSDHHPGSVSDVTIFMTRINKHRLMLSKTEDDKKMIDIREGSSAFPKLWATLQDKGYQGVGDAICSIRPAKKTKNVIATRQEIERNNRVSSDRVLVENMFGRTCSLWKIAYATFTWSEETYDLVLRLVWALTNFHTALHPLRAQDKEFYSSVMARWLKSVLKRRNANAKQVETVVRFVWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XN22</accession>
    <name>A0A6G0XN22_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Polycystin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_002988</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polycystin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000034">
        <property type="protein sequence ID" value="KAF0741795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XN22"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012496"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051223">
        <property type="entry name" value="Polycystin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046791">
        <property type="entry name" value="Polycystin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877:SF183">
        <property type="entry name" value="AT14535P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877">
        <property type="entry name" value="POLYCYSTIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20519">
        <property type="entry name" value="Polycystin_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="568"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="602"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="629"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="661"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="697"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="748"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="Polycystin" evidence="8">
        <location>
            <begin position="484"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0741795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="929" mass="103927" checksum="F05E1959B25B828D" modified="2020-08-12" version="1">MLRPNKRAKATEDSTPLVQEAADEEASSSHYELEEVELQLVHVLKSNGVAEICKTIKAEIDTSWAVQTAFKTLASVGHFYFSCGDQVLAVSPADGFYDSDGLLLALFALKKFPHHRDVLFPALDTISIYAKLDVERALTFCAVDDAIDILMNCVRNHYDKPEIICITQEALGSLVLNDDIRLHIVSSALIKELTELLRRFKSHIEVSRALLYPLSHLVVLKNMASEFVQLNGIPDTLSILKSYKDDQQVAWYALALLNALTTDVYHTTIIASLSEQRSVHTIARAIAKHVDIEEITLEGFQLLESIASLPDFFQVINQNHILELAYHALSLYKGAQYTHTRLEIKKRVLTFQTCAIQDGRAYALQERRTKGDCVLYTCFLLLTAIAAALSPYNQHTSNETKTLIHALHLPKTFRDTGAVWSYLNGPFSHAVFPTVPTGSMATPNMLGGSNILLGSVQLVQTRLNPSGIAAEQAAFGPWDSAERGYVTLLPNSTLAPACSSNVSCALLNLQSDGWLDNLTSSVKVQWNVYNAALDVHVAMEMFLNFPVGGFIQAAVDATPAYFNIYQGLFLISLLFYVDVAMLCFTIYSVWLAVGKLQRYRQYYFHIAAHLVDFSMVVLWLSVWCTRVQFLVTASFSLITQLAGPSYVSLRDVTLLAQQERVLFAFVSLIMWFNWPRYLSLHNLRYLLCVLEATNGYIVAYIALVLVVLVGVAHCLTLAVSESPSSWIDWVVYGLNAMCRGTLLSSSTYFFFVFNLALSLVVVYLLVPLLRMGFALCPREPPRRMLKPVSSPRKGHRRANMKAAFRTAKTVLKRMLEERQQTVRKLSFSPWEMSEANDAAITAVDRGIPSMLQELHRGIARLAMLDHDLDDVTSNLLKRLQQLHLLLRGNFSRSIKTPPTLGSTKAEFNTSYAQRRIYSTTASDDNTTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XNE8</accession>
    <name>A0A6G0XNE8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_003102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000034">
        <property type="protein sequence ID" value="KAF0741916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XNE8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018596"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005352">
        <property type="entry name" value="Erg28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03694">
        <property type="entry name" value="Erg28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0741916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="230" mass="25512" checksum="2EFBB2AF52CD7203" modified="2020-08-12" version="1">MLFQLVRIYLAGGFLVELHAFVRLTWTSTPLGDLNPSLNDTLLDTVPIFRRLFGYYCLTLGILRLAAAYDMQNAALFAALAVTHVLEAVFTIVEVLVYQGIPVDALLQEKNVPNAAFLALLVFQASMMGAAFDVNDVCHLLLNRKEDDMDQQEEYGHNLREKTTSAMHFFAESWENDVMCPAPSTAQNARTGSYLDANVAPWWNGTTRSRVPWTMTTGTGMSPSISLVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XNS3</accession>
    <name>A0A6G0XNS3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AMP-binding enzyme C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_003095</name>
        <name evidence="5" type="ORF">Ae201684_003096</name>
        <name evidence="3" type="ORF">Ae201684_014523</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000196">
        <property type="protein sequence ID" value="KAF0727435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VJMJ01000034">
        <property type="protein sequence ID" value="KAF0741909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VJMJ01000034">
        <property type="protein sequence ID" value="KAF0741910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XNS3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007225"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF33">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0727435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0741909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0741910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="14485" checksum="561ABA94965B7F00" modified="2020-08-12" version="1">MSPYVSQPFVYGDSLHSVLVAIIVPEEVHLMALAKSLNVPGTFDDVCRDSRVVQAVLKELVTISKQNKLFGYETVKAIQLHPEPFTVENGLMTPTFKLKRHDAKTIFRHEIAALYEQCGDLVAGHNVHQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XPE1</accession>
    <name>A0A6G0XPE1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ankyrin repeat-containing domain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_002671</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000029">
        <property type="protein sequence ID" value="KAF0742267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XPE1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009395"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052050">
        <property type="entry name" value="SecEffector_AnkRepeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586:SF3">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0742267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="432" mass="49275" checksum="71BF89A812922FFE" modified="2020-08-12" version="1">MIKTLKMEPSSKSTSLSVLVDPSLFMYICLFQDGIFDDLRPKYAAWRQESRKAKIQFERIYFLDSIEDHSYVLHEAIATHDLELVKRIVRCNRLGGRHTMDFAANHGTLEIVKHLHFNHADGCTKLAMDYAAHSGKLDILQFLHQHRNEGFSRGILDFGAQNGFLDVVRFLNEDVGVPCSTKAMDWAARNGHLDVVKYLHENRSEGCTVDAIDHAAKNGHFHVVQYLHKQNKPCTFLAMDYAAIHGHFQLVQFLHTHRQEGCTAQAMDNAARYNFMDIVRFLHENRQEGCSPMAMDYAAANGHFEMVCFLHSHRQEGCTTDAADYAAINRHLDVLRFLLEERSEGCTEKAALAAARDGYLDVLEILHTYQSQLVETEAVLDKAIRNNQVEVIQYWCDIAKKAGRRLASHWITLASRQTAIKLSTLDMLRTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XPX6</accession>
    <name>A0A6G0XPX6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_002730</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000029">
        <property type="protein sequence ID" value="KAF0742328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XPX6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005277"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034663">
        <property type="term" value="C:endoplasmic reticulum chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10230">
        <property type="entry name" value="ASKHA_NBD_HSP70_HYOU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000004">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF3">
        <property type="entry name" value="HYPOXIA UP-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026169959" evidence="6">
        <location>
            <begin position="26"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="565"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="825"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="571"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="830"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="871"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="881"/>
            <end position="903"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0742328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="903" mass="100445" checksum="ACA2226CE80422CF" modified="2020-08-12" version="1">MKFPVVSVFMALMAVFHHIPTVVEASVAGVDFGGEFFKIALVKPGRPFEIVTNIHSKRKTETIVSFNGEERLFGADAMNIEVRRPQMAYSQIRRLLGTTVTHPHVESLVKQEYFPYTLIQNLTRGSVGLKHSDDHTFHAEELVAMVFTHAKQITNDFADAPVKDWVVTVPSYFAEAQRQAIIDAAEIAGVRVLSLIDENTAAALHHAISLELPEANKPERVLFYNMGSTSLQVSLVEYTSRIVPDGFKKNKTVIDFEVLAKAWDETLGGSQFDLRLADKFADEFNTKLKGEDIRKIPRAMAKLRAAARKTKIVLSANEEIPVVVPSLHGDLDFKGHAKRSEFEALCADLFARVLAPVEAVMKKSGLAKSDLKDIEIIGGGVRVPKIQALLKSYFDRDLGQHLNGDEAMALGAAFRGANLSSSFKVRNIGMTDIASYPIGVRLVDLHSTHEETESTGDEKHWVKRAALFGESQRLNVKKSVSFSHSTDVSCTFRYDQPSGLPAGTSALISRYNITGVEQFATKFADKNLGEPKVTLSFMLDGSGLATIVKAEATLEEEVEVVEKKKIKKAKKEGEDDKKSDDEKKTDDEAKKEEEEEYEEVKTKQKKTHRASLTIVRADDVHRPEAGMAIVPMDIRTKKESIVLLSEMDKADNIRKTNAEAKNRLESFVYESREYLSRNEEELDVVSTAEQREKLSNEVDATEEWLYDEGENLDAKAYNERFSGMGAQLDAMIFRVSELTALPEAISKAEQYVISTKDLLEQWVAEKPQVTDAERADIVAKLDELSTWLVEEKAKQDAIAKYEPPVFTSAQVVKKVSSIKKAVTALSKKPKPVEKKTEDKKDKKSNDTKKESKKASDDKAEADDKAEKSDEAEASDNAEAEDAAKDSETKADDAEVDAEPKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XQ49</accession>
    <name>A0A6G0XQ49_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Anaphase-promoting complex subunit 4 WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_002346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000025">
        <property type="protein sequence ID" value="KAF0742643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XQ49"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002924"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990811">
        <property type="term" value="C:MWP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052778">
        <property type="entry name" value="Centrosome-WD_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16220">
        <property type="entry name" value="WD REPEAT PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16220:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN WRAP73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0742643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="432" mass="47900" checksum="5A627583F366658B" modified="2020-08-12" version="1">MSSSMSVSPPPAPAASSNKNVSQLLAHSSGLISWSGCGRYLAVAKDTRLTVRDIELNMAVVQIFTCVDMISAIQWAPSDATNEPNMQLIFCAMYKRAIVQVFSVVDPSWTCKIAEGICGLISALWTPDTCHVITVSDFRIHATVWSLADATKYVIRNPKLGADGFSFSPDGTYLAVAERIDCKSSKDAIGIYSVESWELIRHFDVASYDVVEISWSLDGRAIVLRDTFLEYRLVFYSVDGALLHQYEPYQHALGVKTMTWSPTGHFLAVGSFDEKVRVISHMHWKPIAELDHPTLITSNTTMDIYKEEKGQWSQVALPCTVPSVSPDPTKEMPKVGVGVVAWSHDAAYMATKNDSMPHHIWIWRTDSMELCASLASSSPIKTFRWSPTRASLAFGCGTPRVCFWSPDGISWYDIPQGIIVIPGRIYIMPCVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XRL1</accession>
    <name>A0A6G0XRL1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed RNA polymerase RpoA/D/Rpb3-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_002137</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000022">
        <property type="protein sequence ID" value="KAF0743079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XRL1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009997"/>
    <dbReference type="OrthoDB" id="270173at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.120.12:FF:000009">
        <property type="entry name" value="DNA-directed RNA polymerase II 36 kDa polypeptide A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001514">
        <property type="entry name" value="DNA-dir_RNA_pol_30-40kDasu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001988">
        <property type="entry name" value="PRK00783.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF2">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00446">
        <property type="entry name" value="RNA_POL_D_30KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="4">
        <location>
            <begin position="18"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0743079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="321" mass="35968" checksum="9CD537256CF02A0F" modified="2020-08-12" version="1">MANTRFPKIDIQEIRDDFIKFELSETDTSVANAIRRVMIAEVPTLAIDLVSIEINTSVITDEFLAHRLGMIPLRLEGGLEAFKKRFVYSADCDCDEHCPNCSVEFELDVRAESGTQTVTSDSLRSLDPYIKPVHFSSEEEANNTQDTGVIIAKLGPGQRLKLNAIAKLGIGKEHAKWSPVAVATYMFEPIITLNQSVLNTYKSEQRVELYKSCPTRVFEIDDTYDTIQVEDHMRCMYCDECVKLANSYRDNPEDDSAVTVSATPDKFIFSVETTGQLKPEEVVIWALDIIKDKLAALKHQCLELSQDEGISGQSVPITPFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XSN0</accession>
    <name>A0A6G0XSN0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_001847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000017">
        <property type="protein sequence ID" value="KAF0743372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XSN0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000698"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0743372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="416" mass="45151" checksum="0A3BBDB3D49D6A2F" modified="2020-08-12" version="1">MDNAIHVFDEDAYVRRSDRAPKKPVQKYENILEDEEIKKAIVNIEKASAAVAARAANGEQIEELPMKISSKSSKKRSRDDNGSGSNVVSLKIPKTVATVLSSYRPCFVCKEQISADCLSHCTLCVNFFHKLCLKDTTVDLECAACEKTRNAVNASKLLNNVARLGEFNHTTQKNVLSYRLTLLHRYMYPSKHPSRAKKAAPVPVKSTPSPKKSSKKAKKSPPKKKAKRDIESDMTPAQTAPLSPLATTSPMPTKQKAKAGKDDSSKKASPTSAKKTLVPTREIEVVEIDDGDDVKVEATIAAPEASPAIFVAPTQDVRPEVDEMPEVPDVGELEVDVASTPPPLQVGGSSSETSLIPNFGEDSTPNLGNEVDDEEPSPAVETESYESAWPTGMFGGNEVSYVLDDIVDKVVDISSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XT66</accession>
    <name>A0A6G0XT66_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar protein sorting-associated protein 28 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_001723</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the VPS28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000013">
        <property type="protein sequence ID" value="KAF0743578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XT66"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012654"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1130:FF:000001">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 28 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007143">
        <property type="entry name" value="Vps28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017899">
        <property type="entry name" value="VPS28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037206">
        <property type="entry name" value="VPS28_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017898">
        <property type="entry name" value="VPS28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038358">
        <property type="entry name" value="VPS28_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12937">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 28, ISOFORM 2 VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12937:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 28 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03997">
        <property type="entry name" value="VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017535">
        <property type="entry name" value="VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140427">
        <property type="entry name" value="VPS28 C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51310">
        <property type="entry name" value="VPS28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51313">
        <property type="entry name" value="VPS28_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0967">Endosome</keyword>
    <keyword evidence="4 5 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS28 N-terminal" evidence="8">
        <location>
            <begin position="40"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="VPS28 C-terminal" evidence="7">
        <location>
            <begin position="156"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0743578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="255" mass="28470" checksum="631BC1E6F6E71B79" modified="2020-08-12" version="1">MNPMYSSTPPPPPPAYAYTSTVQTTTVLQSSTTFAVTRSTSANSISKPTEIKLFESAKDRRMYEDLSDLYAIIKTTEHLETAYVRDAISPDEYTEACTKLISQYKTAETALRNAGHLVSIEAFLTHYRLDCPRAVERLVRLGVPATVVHNTTSTSADAVNVAQTVQHCITLMDSLKLNVRAVDEIQPLLSECMGSLTKVKGLPPTFEGRLKLEQWLRVLNAMRASDELDDDQTRQMSFDLERAYTGFMSFLNKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XT75</accession>
    <name>A0A6G0XT75_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_001460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XT75"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002698"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013887">
        <property type="entry name" value="UPF0592"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35397:SF1">
        <property type="entry name" value="ARMADILLO-LIKE HELICAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35397">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08578">
        <property type="entry name" value="DUF1765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0743814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="793" mass="90270" checksum="384B1A1DF0DEDF8E" modified="2020-08-12" version="1">MSVMTSMWSLAQATRAEERTHNLFTPHVESDIKNIVKKNMVHQSRDLSGWDFDKKIAVLTELQDMIEAPSFRYADWGEPVPAKFKSVPVLPLLLGQEALLDLWDYIMEFCDVVPVRTGARSLFLRLAGCICRRLEFTHDAELNGAPIKIDVTIEQRFNGLLESSMRYCALKFSKSRILTQDHAYFASHIFTAAFYRYPSVAAPLILDAVQDVTTQLCHKSKPGIETKRTHIHEHETMWLFVPDAASTCSDDGGTSSDENPASNGLEGSSSPKSPKSPQLPKRHENSQEPSQTPLAERRAQVLDKFRAYKASRLVETSEVIPITPLLPVQSSSDETLELVFQASLQLSQEDDEAKFISACPQLYDEPRYLQATVVEISLVPFLDRLRTPSRDANLVAIFVSTFHEDSSSWAKALNHGAMLWHCIPGYFVLVRAFVAIFAKVCMRRKKRETLNKEADIVVDPWFPYWESHELEPIYDGLTDVLSHGPLLNVFVQMILESTNMYDPQSVDYSFNILQNVFECAAEVNGPNHPRENSVRGHLPLSFDVAYYLEALRKALTSSHFQIILKVLAFLYATADLLESKRRQKLLSGVVLHEYFFELFLHWNEEVRRMFCHLLVYKLFCSSRLDLPLVSDRVLLATSPFFRPYNAPQPHVLQGLATYFAPPKRPSALSSLDHSTALERLIVWDTTAVLKQSNQKQKQERLFRDSLSDDELMLDLSMTSKLDAVLKMIADQIKSHDCTTYYPRHLQVYAQRAIAQYIGLLYGYYQAAFDHPSTPPPAPILEFNVQNFFGNAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XUV1</accession>
    <name>A0A6G0XUV1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Vacuolar protein sorting-associated protein 16 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_000929</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the VPS16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XUV1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006478"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.780">
        <property type="entry name" value="Vps16, C-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016534">
        <property type="entry name" value="VPS16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006925">
        <property type="entry name" value="Vps16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038132">
        <property type="entry name" value="Vps16_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006926">
        <property type="entry name" value="Vps16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04840">
        <property type="entry name" value="Vps16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04841">
        <property type="entry name" value="Vps16_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007949">
        <property type="entry name" value="VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps16 N-terminal" evidence="4">
        <location>
            <begin position="4"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Vps16 C-terminal" evidence="3">
        <location>
            <begin position="554"/>
            <end position="866"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR007949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0744451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="883" mass="98257" checksum="D3103315C40236E1" modified="2020-08-12" version="1">MDPSEWHALGDVPYQKHQLFEMAPEWKEEVSALGDLREFLVVPAQFGGPIAMIRDPSRLVKMDSKGSLSRTLFIFNACGAKLAAIDFSSFDTKKKTLFGMFWTDEMRLLCVFDDGDCISYSIMGDVENQFTLFPADSKFKVISFEAWGGGLVALLDNFMIAQALDIDSVKPRVYCIAETGVSPANPPTCMAVLDPRFVKSGLPEIFLGTSTNSLVVVSKGTSSSEPNKVMDMKLQSSIKAPISKIAIAPNGMFMAIFTQDGTLTVLNTGFDKKILAFDTQSKTSPAAMLWCGEDSVLLYWQSVGLIMVGPKGSWLKFPCDDGPVSLCQEVDCCRIYSSRTHEVLMRVPRAIETIKRIGSTAPAAMLLDALDAFDSGDAKADENIRAIQTQHTLEQAIMDCITAAGNEFDYTAQSTLLRAASYGKCFFDNSNPAAPGGTTDNPSSNYDSELFVDMCRKLRVLNALRKPSIGLPLTLTQFDRLSCEVVVSRLVALHHHFIALKICEYMKITSDRVLVHWACEKVKSSFETDPSGIPMTDEAIVSMVRKKLKDATLVSYSEIASCAERAGRHRLATMLLDLEENSSDQVPLLLSMGEYELALRKSLESSNTDLIYLTLFHMERTMPPDHFRRVLHSEPQYAEAIHLLSSFYIATKAESTKLENIWHEVSSANYDVLTSFVEPNTDEKLKKLKEAMAKYNSAKLPINAKLTEEQIDLLVEQRKLDEKASAGPYTYVGMSLSDTIRHLCMDAKREPKSLQVAAAIVKKFKVPEKRFYRVKIKALAETHQWDTLHKFSNEKKTPPCGFKAFAIACLQEGEKGQAESYASRITQPDEKFDTLIHLQMWTAALDMAVKLKDPDKLSSVRNNCPLPDIHAQIDQAAQQLGFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XV33</accession>
    <name>A0A6G0XV33_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_000895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XV33"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021035"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0744414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="186" mass="21364" checksum="B968A1759F39C404" modified="2020-08-12" version="1">MMKHEMRAPEASNSNQEYRGPSPDDVQGAPPPVLLPRFHHSVHQPQYATTTPPSPTERTPTPVGFHHPQVDPTSPTSVYNSRIYGDASTSRSFLEYDMRNRLAHEIRTHNRTWREECTNQERESNRRRIENALRTHAPSYDELLLIVSAIDEELLHISSHSKFQYFDSAMDFQRTLESGCTTSYGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XW40</accession>
    <name>A0A6G0XW40_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_001072</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAP domain-containing ribonucleoprotein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XW40"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009482"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052240">
        <property type="entry name" value="SAP_domain_ribonucleoprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040746">
        <property type="entry name" value="THO1_MOS11_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46551">
        <property type="entry name" value="SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46551:SF1">
        <property type="entry name" value="SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18592">
        <property type="entry name" value="Tho1_MOS11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="4">
        <location>
            <begin position="6"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="66"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00046328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0744605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="254" mass="28232" checksum="B29083E2E4D1D66E" modified="2020-08-12" version="1">MAILNPKKMKVNEIKDELAKRGLSQAGLKAELIQRLELALDEEEFGGMDGPDSPVTKVDVTPVAVETKSPVHKKVDSIRSLLNDDTPPSAPEKPVVTQPAVKPVVKPEVKETPAPKPTPLDTTPKAAAALVPQTTTVQPPAKVLTEEEKKRLRAEKFGIPLSEEQKILERAKRFQLPNAKLDETKKLERAQRFGLPIEESAEKLEEKKKARADRFGINAEADKKLKRAMRFNLETPETVEAKKKKRSERFGLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XXM6</accession>
    <name>A0A6G0XXM6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Aconitate hydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_000248</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XXM6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001065"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0170034">
        <property type="term" value="P:L-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0170038">
        <property type="term" value="P:proteinogenic amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01577">
        <property type="entry name" value="IPMI_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050067">
        <property type="entry name" value="IPM_dehydratase_rel_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033940">
        <property type="entry name" value="IPMI_Swivel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011827">
        <property type="entry name" value="LeuD_type2/HacB/DmdB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02087">
        <property type="entry name" value="LEUD_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822:SF2">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="6">
        <location>
            <begin position="76"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="6">
        <location>
            <begin position="305"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="7">
        <location>
            <begin position="532"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="457"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="663"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="474"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="665"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0745215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="684" mass="74273" checksum="9C1DA35618F760EC" modified="2020-08-12" version="1">MSKSTESSTRPMTLPEKILTHSAVGLKHPYVEPGQMICVKTQWTLACEITWKSMDKTYSDMGRPRIWRNDRFWLAIDHTVDPRVNHLPRQQMMIKASTDFAEEAALTNFQKPNTTILHTEFYRQRAQPGQVVVGADSHSCSTGGLGAFAIGLGAADVVMPLVTGETWIQVPETVKIEFVNAPPFGLGGKDIMLYTLGQLKCNTVAIGRCVEWTGNIAPLSCDARFAIANMTAEFGGIAGIFPADERTQAYIANRPSHNQDALYFRADPDAKYAETFQIDLAELTPQVALFPSPDNVQPVSAVLNTPLDGCFIGACTTAEEDLILGALVLEQCLKQGLKPVSNGQRRVTPGSQIIIDHLRATGLLDFYEQAGFTVGAPGCSFCLGIAADVAQDGHVWLTSQNRNYRNRMGKGSIGHLASAVTIAASSFSMTITDPTPYLALIDPKRLESYMPPVPDLPPLEVATPAPEQPLPAGEKSEKGSDEKNTIPEVLEGRAQVFGDNIDTDAILPGEFLCENDVEALGKVAFLHTNPDFRDKVKEGQSIVVAGHGFGCGSSREQAVTCLKGAGVKAVIAKSFGYIFSRNVQMFALVGIRITDERFYELAQPNVPIRVEMRGRTVHVGGEVFRFQMSLFEEKLLAGGGIIPLYKKFGNRLFRVAVEDAEDESSCGTSSGDCGSTTKAVDVAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W3A0</accession>
    <name>A0A6G0W3A0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_019139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000414">
        <property type="protein sequence ID" value="KAF0721433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W3A0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008387"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0721433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="223" mass="23939" checksum="71EC1D7762F4CE88" modified="2020-08-12" version="1">MTMPRSRNNSFFACCDQRTTVFISLGLFILQFALDEHLTMRVFIPLALAASTVAALNQRHQDSPLVMLEHPPQDSINFAVHSRRVLKVQNGRKLAQKTNRLRLAELSSQEESDASDPHLRQLGVFKVAGGACGAVVGAVCGAVEGTATGVAKGLKSLAHGYVGPAVIKTVAGPFVGSGLRAFQGGREGAKLGEKIDKKIGRQAGRIKDKFQGKKSRPKPARQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W3K0</accession>
    <name>A0A6G0W3K0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_019082</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000386">
        <property type="protein sequence ID" value="KAF0721564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W3K0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003654"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05123">
        <property type="entry name" value="STKc_AGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045270">
        <property type="entry name" value="STKc_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RGS" evidence="10">
        <location>
            <begin position="60"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="199"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="11">
        <location>
            <begin position="556"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="358"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="358"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="396"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0721564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="657" mass="74879" checksum="0A94B3DAFEE151ED" modified="2020-08-12" version="1">MGSGASSFQRAGSVRNMAKTSTKMTGRGVPAPLVAANTQWKMVPQTISRDKSMRSIDESELTSMLNDPVGQKHIGNFAKKILTSESFYCWIEILEFRDAPSSGYQRSVAKHIYRKYIRDGASMALGGLTREIVSLYDEKLALIDSDPGVINQDFFSPIQKLCFDDMCRNTYHRFKTSPEFDLYKLELKDTYNKVTVDDFDYLELLGSGGFGRVVHARKKSTGKHYAMKIQLKNGLLHEHQDQLDQITSEKDILQICNHPYILDMHYSFQTSAHAVIVTELVRGGDLNELMKTSKKGYLPEGRVRLYAAEIALALNHLHELGLIYRDLKPCNVLLGEDGHIVLADMGLATGLEEIRAKKRERERTAEKSRDDDDALAVKDNDAASDVGDTKNDDKTSPTGGSQRQNNIPKSFARPPDAKYTRRKTTVGTKGYMAPELISGKLMRREERPGYNYTIDYWSLGVTVYELVCGYQPFNLYNVLGDGFLAEIAQEVEVAKLSPRSQYRAELERMAAGVDYPEYVSEDAKDFINRLLDVNSSQRMGCTGRGFLDIMEHPFFKDLDWEKLMVKHVQPEFTPTLKPLTDRKTYSNFWNMMAHFDARDKHFIRHDWYQDPPPEKQKAFEHWDYISPHTLKAELGIAAEMDESNRPYKILQLTGETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W3W4</accession>
    <name>A0A6G0W3W4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_018878</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000363">
        <property type="protein sequence ID" value="KAF0721812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W3W4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004189"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004706">
        <property type="term" value="F:JUN kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041243">
        <property type="entry name" value="STI1/HOP_DP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF291">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17830">
        <property type="entry name" value="STI1-HOP_DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="40"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="73"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="106"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="503"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="530"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0721812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="774" mass="86820" checksum="F1243B47BCB26342" modified="2020-08-12" version="1">MFDWAKDKDKQLYEAASKGKLSRVLAQLARGAYVNWQSPNGQTPLHAAASQGYLDIVKELISHHADVDKSDKDGDTPLHLSAMHGHLAVVQALLDHGASINAPDNNGRTPLFKAAEGNHEKVVRALLDVGADVTMKTTTPDKKQARDVSNKTIKALLDERQDLINTVVQSFGNEMVPNLAKNPNTVTFLADPELFVKLQNIQQEPLTFIQHKDDPQIQTALAELDRMTRPQAVSENPTDGSTEEPSGMNVQSIQSAVDYIKNALDEYKGKDGASDIVRVGTTILSLALKFQTHRESVLTTALMVDRIMRHENENAIPSQDATTQISLLNETQTNFESALETTEGWKLLVDDITREAKVQEITTDIIRLQDHLSEAAAAINVDAKVQVVGKVEDLAVNIGNMLEMMDRLTQHLESVENTRQLQPQKNKLEELAIQLHRGLEFYERQVKLGNFPQNAAFEKQVETCREKIEEKANVLGQEKKIPYGIHNIECWMLASEDVKFDPNNLNTALGRGGFATVFKGMYQGEPVAVKRFDRMIQSDSQDLENLIAKEIKAWKDISKADYILTLVGVCTKIPTPILVSELCETNIRRYVRDRPETLLPLVYQFACGLRTLHQANIIHRDLKCDNVLVTYKKTVAIADFGLSRTAMSLELTKSRQGWEGTMNWMSPEQFLKPRSVTTKSDVWSFGITLWEILSNDVPFKDWSEEDIVEAIKTDEERPEKPQVEPHLEPLWAIITKCWQSNPADRPVADDIVEYLETHYSSEIHGLPGTAPQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W4L0</accession>
    <name>A0A6G0W4L0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_019011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000374">
        <property type="protein sequence ID" value="KAF0721655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W4L0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002210"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015023"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016696"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="260"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0721655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1095" mass="127759" checksum="6D25775DFF8FDCCB" modified="2020-08-12" version="1">MSYYDWLLLIFQRVDHVQNFEDPEVVETTVAEAKQLLPVLRQANNPGVVWAGWKKRAKKFFQEYHVEHLLANTRVSDLAKRELLRAQEAFNAGRLPTQALEQAQAKYDETMSEWKSYQNDINFDFHATKNETSTAHFFRPPKNVLYNVPILEVQDADGAVSTCPQVIHDVFHAKWSAVMCENDFQAPNRTSRRRFLRLLQKRLTDEQRDSLDSPITTYELAQAIKTMVPHKSPGMDGFPAAFYQLEADLFAEILCLVFKYQLSRGELLGIQRRSAVSLLFKGGDRSNPGNYRPIALIPVEVKILTRALAYRLRDLLPALIHPIQTGFVAGRRIHDHIIFLKDLQHKCTLDDIEGYAMFLDFEKAYDRVNWDFMYDVLEAFNFGPVFISWIKLMYHSPIIHLVINGELSQAIYPTRGVKQGDPLSALLFVLSVEPLSQLLRNHEEYSLPFSEELFAMAMFFADDTTLVSSSLEDLERQLELVQEFCTQSGAKLNVGKCKVLTLNGNQDVPRHPRLSMVTSGTPTKYLGILFGHRLSDQVQINALSDSFYQSFITWGCRARTLRGRRLLANTMMLSKLWHYTAVIHIPEDTVAKWQSMVYKFILTRKRHKEDKHMSLINSGVAYHPSLGLRIPHIASRIRAQRVQRLQFLFQTDNEEPSLWSVLPKQLFRRCMEPFARHSSWDCLMYHPNHNTNHMRLEVLPLLWRKIWDNWHRIPLTRKCPETPTQSQLLTMSIWLQIHPLFLVPGSNGPTSLAVALKHHRPFYKFIAQEGLHCLDDFVTAQRVWPSYEEFKLQMESHVWRFPGDDFPRVFRHLYSLLSLIATNVWQVLGISLEEVVPPNREVQFPVGQVWKNVFVPFQQWPRKYIRSICFCAPLLTKQHPLSSDSRNSDLAIKKYINTTVKPLMRYPTPLQADVWWRILFRMLPVNSRFFFLQDTNPSIIECSYPGCSAVETMQHILFDCKFVKPVWNWHQAAWRPFGIPFTWNTIINLDEFAVSEEWVPQFSVIRRLWVLLVSTLLRDFWIHRNRTKFEGKPVPYIQAVKEVSLVSWTANIRRMLRDPTIDSDEAMQVSEIVDKLKSHTNYTWFWQKNLRATLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W5P8</accession>
    <name>A0A6G0W5P8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_018897</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000364">
        <property type="protein sequence ID" value="KAF0721789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W5P8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005350"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052050">
        <property type="entry name" value="SecEffector_AnkRepeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586:SF3">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0721789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="220" mass="24680" checksum="D6C3DBD76BF2AFB0" modified="2020-08-12" version="1">MQCMPSCLTYLVRYAVWSAKFELLKWLDSRASVYDVEGLLDLAASRGHLEVLAWLHNHHFTGCTRRAMNAAAERGDIAMVEFLHQHRLEGCSRSAMNGAMMNGHLEVVKFLHFHRNEGCTPYGMDMTAKNGHLAVIEFLHNHRFEGCTADAMTWAAAEGHLDVVRFLHGMRNEGYAPWAIEAAASAGHADIVAYLEAHPKDEEAYVSDPNVVFSGRDFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W6L1</accession>
    <name>A0A6G0W6L1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_018984</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000370">
        <property type="protein sequence ID" value="KAF0721704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W6L1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007468"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0721704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="273" mass="31401" checksum="DFBD3FE2F81876C3" modified="2020-08-12" version="1">MKLKHFLQVWLDSQCPQKHRPSPMETILLSDENDRRNGSFYMTNRSAYTMSKMECPPESLRKLGQDSLQVTLHLDQDDDGTCIHATECHIQFPIDASKEYAYLSINQGVNIQLTTFLDCREQEHTKLKFKWLCVAGVFLDDENNRITITQTAIALDDRFPLVEVESRSNGFQWIVFQRITDRLTVVRWSISNFCPVNADGPISLREYAEKLRCNVNPKDSEEALCAKIQSGLEQALGNLRDQFRSRFKLEPTTMGSRDFAMESRAHGNDDQDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W7B9</accession>
    <name>A0A6G0W7B9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_018070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000319">
        <property type="protein sequence ID" value="KAF0722995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W7B9"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0722995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="79" mass="8486" checksum="572464BCC256E649" modified="2020-08-12" version="1">MTTRVASLLTKKWITGSAIPNFAIASGVAVGAGSAARQVAVWEDEASTTNSTASAFNTIHGPKHHDLEQFEAFMMMMMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W7I2</accession>
    <name>A0A6G0W7I2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_017964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000317">
        <property type="protein sequence ID" value="KAF0723093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W7I2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021550"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="247"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0723093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="361" mass="42073" checksum="EA34060021E8FEC4" modified="2020-08-12" version="1">MNQQLLDDLARLELQHKDGETEHRELQQHLADQEAAYLELEDELRIVKTQHEQDFGQAYEDYQKQLQSTKESGSGRQQEILVAEINRLSDLVNSHENQAHEQAAKIEHLEMSTQTKSRLIYELEASLKRRVSPRGQPGLPCQICPTIQRELLEARSRIRTMTDRHAVEISTQVADLESRWKSAEAGWLQEKSDLNEKLQQQSTLVLEANRIARSQEATMIRAKQETDLLNSDLRRVQLEALTRTTELEDCKKDQDRLRKEQVSLQRQLEEKSANYDRVSRQADQLMRTLQEQSARRNEALRSYDARPARPTIDNAWVDFLAPLRRRYSPCPGYKQPAWGPPKTEDKRWSRLLIRLPKPGPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W8B4</accession>
    <name>A0A6G0W8B4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial import inner membrane translocase subunit TIM23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_018230</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000326">
        <property type="protein sequence ID" value="KAF0722753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W8B4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000661"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045238">
        <property type="entry name" value="Tim23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371:SF0">
        <property type="entry name" value="SD19278P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371">
        <property type="entry name" value="TIM23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0722753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="20988" checksum="D06D7FFD7F46DC7F" modified="2020-08-12" version="1">MSNGGWNDSEFKNDESFDPYAHSGPLTLPDFGGNSQIDLGAIAPVFGIASNNAASAADYLEFDTRGRGFHERATHTIGMAYFGGILAGGAYGVVEGVRNAPSNKLKVRLNSLFNAAGHRGSRAGNALGILALMYSSVQELADTVELDRFVLLDKAVPVLAAGATGMLYKSTAGTRPMLMAGAIGAVLMGTVQFGSSVVGLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W8C8</accession>
    <name>A0A6G0W8C8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_017660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000307">
        <property type="protein sequence ID" value="KAF0723430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W8C8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013541"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0723430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="301" mass="32463" checksum="2AA63DC07726F305" modified="2020-08-12" version="1">MMPKRLLYGLAALAIIPVLMAWTSMSLFLGRSKPVAAIVSILAIVGVAVVCVLQDNLVGYDIPAVATATILLLTLIPRKLLVVHVSLVVGFLSYAITRRRYSTLGPSSALDNLVLLSSIAIVWTFISAQSLWIRANSDALVQAEGVLYKTAIQPIHHLLVVAGMGTVHVPYAGKDTSKKPLTVVLIHGYAAGNGFWALTLNHLAEHFNVVSPIDLEMSSFTLSWHLNPTMRPTRSSLRVWNDGVKSSSSTRWSCVAIPPESMVIGVDQFGEGLVGKHHSEFEEFVGPTVDVSNAGPTFRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W8W2</accession>
    <name>A0A6G0W8W2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kazal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_017525</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000300">
        <property type="protein sequence ID" value="KAF0723622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W8W2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012339"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050653">
        <property type="entry name" value="Prot_Inhib_GrowthFact_Antg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10913:SF45">
        <property type="entry name" value="FOLLISTATIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10913">
        <property type="entry name" value="FOLLISTATIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026245026" description="Kazal-like domain-containing protein" evidence="6">
        <location>
            <begin position="23"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="465"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="7">
        <location>
            <begin position="221"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="124"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="179"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="291"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="497"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0723622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="533" mass="56281" checksum="B347D3853854899D" modified="2020-08-12" version="1">MVAWPKVIALLSLILAVGTVEGAIEGKKQCKRDYHVCKDGSKVYRNKQNDCDFDLCPEDVDSADGGEENEDDKDVVNAKAVVFVTTAPLPVVASTTAPPQANATNASAPVAVATTAPTTTISIVATPSGAGQPTPPAVASTTTSPANHPSEVPKAPATTIPSIANQTNAANATTHIDNSTIQSPASTAPVKTPAKTPVKTPAPSKTHKPRTTSSHEYSSKTKPVTRCQTGCIEIFKPVCGSDGTTYGNACELKNAACDHASLHVAHEGSCNNEAHDKGSVGSVESAVIVSPHTTSLPSKKPSTNASSTTSPSATSANGWTELEAAPSLVWAATYKAFSLYSNPDVCSLMKAEPGFTERLNNTYHVVAHVDCRLHGTSVVVGQFSLTFEPEEDSDGLQLTSCAFHDRWGMLQNWLIVDLETETAVCETPAQKSHFDAQPLQYAANRTTVSMAQDYVHEIVQDKTKLVGVAAAVGAFCTLAIVGMVALICRRRKNRDRYGKDEAPAQANNDEAEQEKVPLSSKSPAPDVEEGKFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W8X0</accession>
    <name>A0A6G0W8X0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_017785</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000312">
        <property type="protein sequence ID" value="KAF0723266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W8X0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018098"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
        <property type="entry name" value="FYVE_like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="START" evidence="6">
        <location>
            <begin position="144"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="5">
        <location>
            <begin position="271"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0723266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="377" mass="42940" checksum="AF75456F776047EB" modified="2020-08-12" version="1">MPLTVPLPSDYFKCPPLSQREMDHFIQLGTQSAHALVQKANLTGGTYDWKLLKDESELKIYKAYNAADDSHLHCGVMQVVGDLDENMALHRDDTTEQAREYIRRFGRLYADVVNLYTVVPRHPDRPNDARQIKWFLAKSPLDGVVTRRDFVMLETEFEFQANGKRAWVRSYSSIELAAVPDMRKELGCIRASMYDTGFVVVESDRPGYLDMTYLADLDVKGHAPAWVIDQTLKFWLRSMLDIDRFMRENRLSRSRFLSRDQLSPLYSRVRCALCRRKFGPLRKKSNCQKCGDVLCTSCNRLWNVVVNGVDAQVRVCLTCSLGTPQHALLTSTAKWSVDPVFQTPPLDGNDALSEDGLPSYCSSEIESLAHPITLYTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W9A6</accession>
    <name>A0A6G0W9A6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_018233</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000326">
        <property type="protein sequence ID" value="KAF0722756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W9A6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000664"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0722756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="620" mass="69816" checksum="D7654AEA5024FF3C" modified="2020-08-12" version="1">MGAPSSSPSIADAKRSLSLNTCGHIELAGPKCFPHCCPNHVYSSVCGTSIVVRVHGPLVMLENTLTYLRFDASYEPPLAVGDTMDENAVLSNLRHQTHLAGEWIASKFEVVDEKMQSRVYEFSPKSQSTLGWHYRWVGGSARQQRRAVHYLRAYVFVKESRRLRVVAMAQSSPFIVMSYRRACKACQRQSPDDKQLDLQCQCGGIYRLSANALLEESSNQQMRKLREMATTIHPFPVQEYDPGYDNRMETALATIHYFVSTFPISILAAYLDPFDQMLRVHPTRRTHSIRDEIRAHLQAPLDRLAEWSPTLQAIGAVVSSSTDLTPFIKSFSAAHAASLLSKQALEKSYAAFVEHVFNYFRQILAPFNLTPHALSDDILALCAVLHAEFPIPATTCVEKCRAFRLSVAFETFVAHMREIYMSFNMPPDALPAPTSRPLEGHWRYKALAIKHMSSHLCPSVVTLMRACYMGVSFQIVDTAKSFFIQSQHAFTNKTWAEFRLDGMPHVHRVFPDGESTMASLGGLIHGDYVAAVVHASSVALTLFSWPASRVSRLCYAVHFHLVRVDENGLKVDVRVAAAPEMAPVDDYWCMTVHERIALYDERCESPVVSFQIDYERHSME</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W9R2</accession>
    <name>A0A6G0W9R2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_017313</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000292">
        <property type="protein sequence ID" value="KAF0723933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W9R2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016093"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24342:SF14">
        <property type="entry name" value="DEATH-ASSOCIATED PROTEIN KINASE DAPK-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24342">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="353"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="113"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="244"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="265"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0723933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="629" mass="71045" checksum="7FE0AF914DAE4A82" modified="2020-08-12" version="1">MSLKTVYVEMAVRDNRGTKRLTVVKSSEPARVHFTDTSPPVAASTVIEQYHHKKLNSTFMPFISRGKLLARVQESGRKHYRPVLDLQNVKHNDTLIYHPCAEMQALLEKNKCLTPAPPRKSQEMTHTPTKTLKRKDRSLSEDRLRAFMQLSSSSGSYMDPTESSRGSADDLSDEDVLDAHGKIMKPKLSKSSSKIRDVHKPTTPTNAPQQVDMLSKNFAQLDVVSDDDEAVNVDIPDIFMSYHPRRNPVAQSEEEKDDDMGDVFLTSSAGRPSIGSPSILSLDSTRGSSPSLVRKSRPSLESMRTSRQSSDVSMSDLTMLDSFDENTCYYTGFSYRDSLRESITVRSDFDAVYQLGKQLGKGNFSVVYEAARRDRPTKKVAVKIIDKLEVHEPRFLFREIEILSSLYDDGVVHLLELYENADHLYLVLELCGRELFDYIDEHGPLTEVQANGLIRKLLRTVSYLHQQAIVHRDIKPENILLVNRDSLDEVKLSDFGIARRLHDGGNRTPHTIAEDQPLRTSMSDLGGQPRERYARAHTQCGTRDYIAPEVMTGKGYGVEADMWSVGVVLYVILSGFAPSFSPDLELVFGEECWQNVSEGAKDMMRRLLVRNPETRMTAAQALQHPWFQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W9T4</accession>
    <name>A0A6G0W9T4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_017246</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000290">
        <property type="protein sequence ID" value="KAF0723973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W9T4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018035"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01869">
        <property type="entry name" value="Rab1_Ypt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057289">
        <property type="entry name" value="Rab1/Ypt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0723973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="202" mass="22379" checksum="9E11C4A392F5ED81" modified="2020-08-12" version="1">MARDYDHLFKLVLIGDSGVGKSCLLLRFADDAFTESYITTIGVDFRFRTVKIDKKTVKLQIWDTAGQERFRTITSAYYRGADGIIMVYDVTSQESFDHVNDWLNEVNRYASEGTCKLLVGNKSDMSSKKVVSFDTAKAFADSLAIPFLETSAKNAQNVEEAFLTMASELITIREMVGGSQKPHGTTLTSESTKSSSSNSCCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WBA6</accession>
    <name>A0A6G0WBA6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_016856</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000270">
        <property type="protein sequence ID" value="KAF0724449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WBA6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000364"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0724449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="133" mass="15033" checksum="B000D8DC8D31C69C" modified="2020-08-12" version="1">MALSTAVSGQSKLYVCSASVPAMIGTYEIDDELISDDAPVYTRVDPDDYNYDADPANDFRLFRHRGFWSFADFASWPPEVHFRCDPHLNDQDQACRRNQAAPPLEGYSPRLGTELHSPVVQLQPCLPELTHEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WBG6</accession>
    <name>A0A6G0WBG6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_017314</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="VJMJ01000292">
        <property type="protein sequence ID" value="KAF0723934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WBG6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016094"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000019">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0697">Rotamase</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="8">
        <location>
            <begin position="87"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="260"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0723934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="332" mass="35890" checksum="F09D539F04361B71" modified="2020-08-12" version="1">MYYSRVVDQCRLINMRRTIFAGQRAFSKLPTPLDEPKSSFGLGTAILVGGLFATGYFVGTSIGLVPTDQIFPRKRSDVKLDVRSKVFFDIGIHGKDAGRVVIGLYDDVQPKTVANFIALCTGEKSSPAQGRLHYENSPFHRIIPNFMIQGGDITNGDGTGGMSIYGRRFPDEDLSIPHGGPGTLSMANAGPNTNGSQFFICTAETPWLDGKHTVFGKVLDGMDVVEKISSYGSSPSGRPSADVRIKRCGRLSDDAATAEADNSSTSGNDAPTAITSRLDDKVELQERLDSLREVEAQFKAKKDAIDATLYAQMLADIAAEKKRVKSILKKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WD64</accession>
    <name>A0A6G0WD64_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_017032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000275">
        <property type="protein sequence ID" value="KAF0724252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WD64"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018344"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0724252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="316" mass="34967" checksum="FD7474E4009DFE28" modified="2020-08-12" version="1">MGIQDLVPANTTKAKSTAIKAFTRFVTEENVTMEYIQSQFALDTTGVLMERVLDKFGSYLAFLDTKNGKQLARNTAMSYYRHVKLWLIELYQPSPIIVAKLLKMGTTLDRYCMKRDKGGFVKKAVACTKDHLRTLMVHQYSTAKNATDYQDAALLCLLWYLFGRASDLSSLRKTNLTVSAGGVLFVRLMRMKTSEEQGLSLYYDENYLACPITSIAAALVMQTTPDVALLSHLPDSQDQIQLDSVPSMPLMDLLNGSLGADSSSAPKADVEVKKSVTQLTALPGVHSHINRLLNRISKPAGIETELTSHSFRRGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WDF9</accession>
    <name>A0A6G0WDF9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cellulose 1,4-beta-cellobiosidase (non-reducing end)</fullName>
            <ecNumber evidence="3">3.2.1.91</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ae201684_016104</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains.</text>
            <dbReference type="EC" id="3.2.1.91"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 7 (cellulase C) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.91" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000243">
        <property type="protein sequence ID" value="KAF0725331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WDF9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008017"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016162">
        <property type="term" value="F:cellulose 1,4-beta-cellobiosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07999">
        <property type="entry name" value="GH7_CBH_EG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.100.10:FF:000001">
        <property type="entry name" value="Glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.100.10">
        <property type="entry name" value="Glycoside hydrolase, family 7, domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001722">
        <property type="entry name" value="Glyco_hydro_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037019">
        <property type="entry name" value="Glyco_hydro_7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753">
        <property type="entry name" value="1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753:SF2">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00840">
        <property type="entry name" value="Glyco_hydro_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00734">
        <property type="entry name" value="GLHYDRLASE7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026133709" description="cellulose 1,4-beta-cellobiosidase (non-reducing end)" evidence="13">
        <location>
            <begin position="21"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="14">
        <location>
            <begin position="505"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="460"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="460"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF0725331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="543" mass="57617" checksum="92F20A069A8ECAAD" modified="2020-08-12" version="1">MKIAATIAYLATALVAFSDAQNVGTNMPEVHPSLPSQTCTSAGCTTENTKIVLDANWRWTHNVGGSTNCYTGNTWNSNYCPDPVTCSTNCAIDGADYAGTYGVTTSNGQVNLRFVTRGPYSTNVGSRLYLLEDDSNYKIFNLLNQEFSFDVDVSQLPCGINGALYFVQMDKDGGKSKYPLNKAGAAYGTGYCDAQCPHDVKFINGEANVNNWVPSKSDPNSGTGQYGTCCAEMDIWESNSISQAYTTHPCTVTGQTRCTSATQCGDDATGNRFDGVCDKDGCDFNPWRYNNHTFYGPGSNFAVDTTKPITVVTQFITDDGTANGNLVDIKRFYVQNGKKIDNAPISWSGIDSLNYLNDNVCNEAKTLFGDTNDHAKKGGLKGLGDALKRGMVLTMSFWTDHAAQCLWLDSTYPATKDPSVPGVNRGSCPTSSGVPADVQNQYPSATVKYGNIRVGDLGTTTGSITPVPSSPTTAPTTAPSSPVTTKATSAPATSSSAPATTASSGGVGAYGQCGGTNYKGATTCLSGYTCHFYSEWCSQCIPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WED9</accession>
    <name>A0A6G0WED9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_015897</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000235">
        <property type="protein sequence ID" value="KAF0725679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WED9"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="52"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="54"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0725679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="19913" checksum="FE59ABCFC3985BDC" modified="2020-08-12" version="1">MGVQVATSESMHPVLTERSKVDSLWCMYAWFLASKSARDQARGLPVDVVARSQCHYCSKPFHALRRKTHCLTCGQVFCSDCIGQWRHARRETEKVCLACILEHIKAAHTRQSRRPPVDKYMPCVIIEESDEDEDKPPQPMLVLNPRQLSEIEAKWALIRQADEPSPLRTVGLANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WEL9</accession>
    <name>A0A6G0WEL9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine protease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_015643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000229">
        <property type="protein sequence ID" value="KAF0725978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WEL9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013892"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36234">
        <property type="entry name" value="LYSYL ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36234:SF5">
        <property type="entry name" value="LYSYL ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13365">
        <property type="entry name" value="Trypsin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0843">Virulence</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0725978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="404" mass="43157" checksum="7324A383C1344015" modified="2020-08-12" version="1">MVSKSLLCFTFESAMWSFAKACLVLSIGLVGLVASQDTTAMVPLDLGLGCARGTYPTSPTVVSFVVDQPQADLLLVHFGLFDLPPSDFIAVRSVVNHTVGGVVHTIRSGALRAPFFSLPVYASMAILELHIQQQVVNERNAPRCYGFHVDGVRTSIADGNKNVAADESLCGVDDSKSAECYINTSMYRASKAVVRLVTNRPTGSAFCTAFLLGNRGHLLTNNHCIKDETDAENTMVEFMAEGTSCDDTCDAQGACAQNQFIRGVRFIVTSIDLDYSLVQLQDEIPSDAGFLQLRASGPVLNEKIYIPQHPMGWGKHLAVVDGNKPGTITTLSLSGCATDQAGYMLDTQPGSSGAPVLSMKDNTVVALHHCGGCPNAGIQSQKLIADMRRRGVLPVAAVANHESM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WEQ2</accession>
    <name>A0A6G0WEQ2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Multidrug resistance-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_015773</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000232">
        <property type="protein sequence ID" value="KAF0725808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007077"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007341"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000006">
        <property type="entry name" value="ATP-binding cassette, sub-family C (CFTR/MRP), member 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000063">
        <property type="entry name" value="Multidrug resistance protein ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000610">
        <property type="entry name" value="Multidrug resistance-associated ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000997">
        <property type="entry name" value="Multidrug resistance-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="709"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="763"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="838"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="864"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="948"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="94"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="406"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="720"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1041"/>
            <end position="1275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0725808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1287" mass="144841" checksum="EB5283C74A9EF854" modified="2020-08-12" version="1">MRKSKYGAINVEKARESAKHPLDTAGLISRLFYTWATDLIALGNERQLDSLDLWPLQQENTCKVVYRAFEPKYEESKSIFRAALTLFGPRALYVVFLRLVVMLASLYGPVVLQQVVEAVESNTVDFWTLSTPIFTLFAVKVVQVVVQAQSDFYNQRIYIQFTSALQSLVYKKMMRLSAKSRKLKSMGEVSNLFTSDRKQLLAVSFTKNDIWITPLQIIVLMYMLWQILGWTMVSGICVMLIALLLNRYLALAMGKTWDALMKTKDIRMKIVNEAFGSIQILKFYTWEERYYEKIQELRDDELRRLWTASIIQASLTVTNFATPVALTAVSFAAHVLIMGQVLTASKVFTALSLFGLINAPMMQLPQIIATWMQAFVSYKRFTEFLGLEERDPNAVTSTVSAHDIDVEILNGSFGWDVQNPFFQNSNLTIKRGEFVVLHGSVGEGKSSLCNVILGELEKYEGSVGVNGRIAYFSQQPWIQNMTIRENILFGLPYDRVKYNKVIEACALAKDLTLFAAGDRTEIGTKGVNVSGGQKARISLARACYSDADIYILDSPLSAVDAIVQNEIFTKCLLGLLRYKTILLVTHNPEIISSPYVDRKIELNNGKLVETECKSKKFDSTILISPFKARRTFMEDHDICAEFEGHAFHSNGCVISTSTLSQSGELDEYLFTPVDKYQGKIFSEADTSGQLVFAEEREFGRVSSNVFSSYFHAVGGWPIVVMLLAFQFLWQSFQVSSDLWLSAWTSTSSSESSDEFYARSRFNILVYVSLAWVSSIMVALQSITISWAGLRASKILFDDLCKSLLGAPVRFFDTNPMGRILNRLSGDMNQVDGEIPGSVSYFLTTLFVLLFSWGMTIIIVKWMGFILLPLLWIYFNLGSFFILPARELERLTKTTRSPLISHIYESIDGFAVLRAFGSSHVQRFERIHQARVDMDIEANFSLDLAEQWFSLRIGLVSAGLILVTTLSLIVMRQYLTAGLIGLVFNYALQMTSQLEDLVWIWSSLETAMIAPERVAEYTNVEQEAARIIPGSTPNLWPQDGSIQSDNVSFRYKPNDPLVLKYLNFQVRSGEKIGVVGRTGAGKSSLIMALFRINEIASGTITISGVNTATIGIKTLRENMAIIPQNPVLFKGTLRSFLDPFEQCTDAQLWDALSKVRLTSRISSVSDKLLSVVEENGDNYSVGERQMLCMARALLRQCRIVVLDEATAAIDHELDQNLQRVIREEFASSTVLTIAHRLDTVFDNDRIFVFDQGEIVQCDTPSKLIQAGSGVLFDLCHESGFLDKLINSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WEQ7</accession>
    <name>A0A6G0WEQ7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_016058</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000241">
        <property type="protein sequence ID" value="KAF0725495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WEQ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009058"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="8">
        <location>
            <begin position="312"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="558"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="593"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="614"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0725495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="741" mass="82811" checksum="2799658B6C439B0A" modified="2020-08-12" version="1">MQVDDDGRNRPVSFQSRQLRAAERNYPVHDLELLAIKYALVKFRIYLLGSKPFVVYTDHASLRYAVKTPHISERMARWFSFFAEYTMTVEYKPGRENVLADALSRRPANLGPETTELSVVYHVHSDLYDRIRCGYRNDPALKAIMAQLSETTSRSGPTSTLERYSIRDGLLLHQPTRTTTPRVAVPCDADLRSELVKEFHDTPSGGHLGRDKTHVTLARSFWWPRMFKSVARYIAACDVCQRVKSPPSVRAPLQHLQIPDDLWASVSMDYIFGLPRDNRGNTGIWTCVDRASKYLVALPVKASITAEQSANDRDPRFTSTFWTALFSLVGSRLNMSTSEQLESDGQTERANRVIEDVLRSYAQSRQKTWSSLLPQVEFAYNSSTNASTGFTPFYANYLRHPRLASSMDNSVSSGGRFSWQTSMHSPDWEPSAGEEELPARTIASVKHFAKVRESILLQVQDNIAEAQSRQSRAANKQGRRRNAFALGDQVLLHYSLVPKAILGNAETRLQWFGPFPITKVISRTAYRLALPADWQTHDTVYFGKMKAYIPQVAPAPELSTAQPHEHSAVQPHAQPNLVDQSLVERDDPRRTTRLPSLQGSSVSRARGQDQKLGSSSPRSSARAAQREGHREAALSQPQALLVWTAPLGLKADSPGRLDVAKPNDAAAGVAQTAPANDYAPMTTRASAARGHANTTDIVSTRESAIATPMRISCVPINRCERLRHDLQGWLHEVSRDSSPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WEU0</accession>
    <name>A0A6G0WEU0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AP-2 complex subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_016494</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <location evidence="1">Coated pit</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000254">
        <property type="protein sequence ID" value="KAF0724934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WEU0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003159"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030122">
        <property type="term" value="C:AP-2 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017104">
        <property type="entry name" value="AP2_complex_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003164">
        <property type="entry name" value="Clathrin_a-adaptin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02296">
        <property type="entry name" value="Alpha_adaptin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037091">
        <property type="entry name" value="AP2_complex_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0168">Coated pit</keyword>
    <keyword evidence="3 7" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin adaptor alpha/beta/gamma-adaptin appendage Ig-like subdomain" evidence="10">
        <location>
            <begin position="678"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="608"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="620"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="7"/>
            <end position="8"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="53"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037091-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0724934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="914" mass="100930" checksum="280EBBE7CCAA07F0" modified="2020-08-12" version="1">MALFSARGLSNFISEIRSCTNAEDEQKRIDKELNKLRQKFTQAGQLNSYDKKKYAWKLIYIYMLGYDIDFGHMQVINLVSGAKYSEKCLGYLGVSILLKSSDELMTLVVNSILNDLCSPDASFQCLALCCVANLGGMELCETLAPHIVKLLMSSSSICHVRKKAALCVRRIIPAIPDVVTPEELEPRLQTLMEDRHLGVVTSSASLLQMALTQNPNGYKSLIEVCIDRLSQLVHNKGCPRDYMYYSTPCPWLQIKLLRILQQYGVPEDVRLSEKLNDTLRKILGRPSPGKGAKNNAIYAVLFETVNLVISQGKRADPKLHEQSIQLLARFISVSEPNIRYIGLDSMNRLVRQEGASEAIRQHKATVIFSLKDADNSVRRRALDLLFAMCDHSNALEIVGELVTYLAVADTIIREEIVLKAAILAERYAKDLRWYVDTVLQLITIAGADVPDDVWHRVVQIVTNNEELQKYTAQVMFRALEPKHVDETTAKFGAYVIGEFGFLNVDEPDMSSERQFEVLYQHYTTSSIATKCLILTAFIKMDNLYEDIRPRVLEVFKKGTSHVDLETQQRACEYFTLHHSGDDTMKTVLEPMPVFPDTRESALVVRLRAQQQAAEGEDTPSSASSSQSYSTSGNDKSNHASNEPDLLGISSPSGGGAATNDIFSTSAAVDPAKLAGWFNKIVATNQGVLFENDVIQVGVKQEFRGSQGRLTFFYGNKSSQTLTNVGATVKQVPFFRTQIDEVAKELAPKQQLKQQLMVECMQPFVAPATLVVAYTIAGAATPTSIEMSLPCVATSFFEPVKLSLDDFNKRWGALEGQGREQQDVFAAKADIQASAKVLVDVMKFGLAEGGESVASGMISLAGSFRTGTAAPSGDKISVGCLLKLESQGNSHRITVRAVHPDVSLAVKNNVKLALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WGS3</accession>
    <name>A0A6G0WGS3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutathionylspermidine synthase pre-ATP-grasp-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_015372</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000218">
        <property type="protein sequence ID" value="KAF0726350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WGS3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005748"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005494">
        <property type="entry name" value="GSPS_pre-ATP-grasp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03738">
        <property type="entry name" value="GSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutathionylspermidine synthase pre-ATP-grasp-like" evidence="6">
        <location>
            <begin position="108"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0726350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="494" mass="55195" checksum="47A1E2C742F7ACCD" modified="2020-08-12" version="1">MTTTSTMMMPMDDSMPKISASVDESIRKTASPFKCFHCSHGCSSPTSIDTCPFRDTELPNAVSDDLAVHKIDIPRDVADAPWLDARLPYVQVFQEQMGTTKLASGPTSSYYTISASGQEGLEYATNQLHHMFLHATQYVLDHEDELAPLFHLPQSLWPRLQESWTRNRNDIVSARFDFALTPSGIKTYEYNADSASCLFECGHSQDAWAAAARLPGHSNSSTLFAQLVAAWRAKGVEGMLHLLCDDDLEERYHSLYMKSAAEAAGIPSILIVGVDSITYDLEGNVFRDSEGNAIRNVWKTWSWDTVLNQYKANEAQHRERRRGGDEDTPQCRKIKGSTKVQARVQVMDILLHETIRVFEPLWTLLTASKAILPVVSMLHPNHPFLLRSTFDHADVASFTTGYCAKPVMGRTGANVSIFDENHNLISATGGKWDKDNILFQELALLPKYNGKYVQVNCWAIDGAYGGTILRVDESNIIDGNSSMYTMRVVDDHEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WHN4</accession>
    <name>A0A6G0WHN4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cytosolic endo-beta-N-acetylglucosaminidase TIM barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_015096</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000210">
        <property type="protein sequence ID" value="KAF0726697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WHN4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012018"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033925">
        <property type="term" value="F:mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032979">
        <property type="entry name" value="ENGase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005201">
        <property type="entry name" value="TIM_ENGase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13246:SF1">
        <property type="entry name" value="CYTOSOLIC ENDO-BETA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13246">
        <property type="entry name" value="ENDO BETA N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03644">
        <property type="entry name" value="Glyco_hydro_85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Cytosolic endo-beta-N-acetylglucosaminidase TIM barrel" evidence="2">
        <location>
            <begin position="244"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0726697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="742" mass="80850" checksum="0883B9CE9CC57161" modified="2020-08-12" version="1">MDQVPPQQDELVQVQAFSRSHVAISGAVCILAGVLTLVYYAKSRPRLSSPAESPTKPAVSPMAKYETFISSILAQEPLVLIALTNEDDTPLVKLCRRNQVQVHNVSFAKIAGRAMLTSTLLERFPGIASTAVEALFFHGELVGDTESVLEMARTGVLSERLGLSVALEEEEQLKVLQWTPPTNDIVASAPASRLPDSLSALLAWTPHDSAAVPLAVRPRATNTCRSQLLVYISCETPSLPVLPWAIIDTIVFHAADLLSLPQAGWIDAAHRNGVRVLASLTWSSIESSTAADWQQLAKQLHRIQGSVGFDGWHVDCPLRDASILAPLMHKESFVLFATDCVDEKEALGSLLQHFHGLVVKTPLERGTINLLARAAGANHWQLYFRPSGDDDDAPTSARLFRFTEVSVWISHTALEDPFWARNWRDLTPVHDSFGGVDTLYTSFNIGSGSTSSCGGQVVRSEPWVDATQVDMLPLLGSVNSTIRASFDTSFAFHGGSSLRLEGMLGPKERATLELFKVQMQFEPLKPIRVAYTCRSDHDPTTFGVVLTLATKQELVLRAATAGSTTPLSSTHLSPLVGRAKNGHVYGATAQVDHGHGWVTRVYHLGGAVWDGKVIRAIGVFGINLQAQESTPWSMHLGQLVVCRLADLPPHPPSLKDIRLEESCSRLAWTVNSSRSVVQYTHVFQEQTDGSKTWLGRTNTTTWPLLAPEEATPSTKIFVLAPVDWSGAVGDIHRVRVVVADGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WHV7</accession>
    <name>A0A6G0WHV7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_015053</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000207">
        <property type="protein sequence ID" value="KAF0726797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WHV7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010312"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0726797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="470" mass="51974" checksum="5BB261E0C43195DA" modified="2020-08-12" version="1">MAEWHAVATTPELVQSIAHFAGDTATFFSYLVALQPSNALGDLELFLHLWRVGNKSKRLLRCQLWPELHLHWIDDDVAPLIRRVAPLVGTVHTHEVYDLAALARCVPANQPIAIHDCPHKSDISTSLAEWYATLRPFNLVHVGATRGWSHHGAQGIEWLRPFSCLRSLILHELDDASMERVVGFVTSSSITHLSLGACFRAHITNVIARALTRWLTCGNSVSLRLHQWVFCGDKINMHALYHAMFTAPLEELHLIASELYHVSSFRLNSSIQPASVCIECCGLNNTALATIFSGLKGASTTSFSLNGPMCTPSSIEYLGDALRHSRLHKLYLSTPMVASACSAMLAKALSNGTSLRELYLTGMNICDVHPLTLVIPSILSLQILDLSDNPIDLEGASQLIETTKNCCPGIEMLKLHHINIHKHDVDTLQRLIDNRTNSISSNGFLDMLERLRADLLIDIKHEAISESACS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WHZ7</accession>
    <name>A0A6G0WHZ7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_014968</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000205">
        <property type="protein sequence ID" value="KAF0726825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WHZ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013587"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0726825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="182" mass="21070" checksum="C5C74B645FB76F03" modified="2020-08-12" version="1">MELRTQYTVMGNTRAVADVIWNPNVRSSPQHAVQAIDMVHDHLLYISMDYGPLKYKFLQLAAMFELDGRIVITNSTIAFDERFPMVDGESRVHGYAWTVLDPLEDGRTLCRKSIWQYTPVNKHGPLTLEEIGILVQDELRSQEPRENIITKFQDVIEDGNIMQREVQIRAKFPPRRSIFVIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WID7</accession>
    <name>A0A6G0WID7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">serine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Seryl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_014959</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="1"/>
    <dbReference type="EMBL" id="VJMJ01000204">
        <property type="protein sequence ID" value="KAF0726969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WID7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015103"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="entry name" value="Serine-tRNA synthetase, tRNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="11">
        <location>
            <begin position="143"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="265"/>
            <end position="267"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="352"/>
            <end position="355"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for serine binding" evidence="8">
        <location>
            <position position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0726969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="426" mass="47187" checksum="3E8283D5ABF88CA8" modified="2020-08-12" version="1">MVILATWCRRSFSTIKSRLDFKALSANVDDMIHNVAIRKSGGDPARVASLYAEYGSATNQVYRLRQERNALAKQGGNIERGRAIKSELAALEASLEALNDELEREALLIPNRTHPNSPVGPEENSVVLKTIGTKPTFDFEPKDHFDIATDLGILDMNTKIAGARFATLKNEGALLELALVHWSMAKLRAKGFTIHLPPDVAHSSNVEGCGFQPRGDATQVYSIANSDLCLVGTAEIPLAAMYGDSMLHTTKDLPKKVAAFGHCFRTEVGHGGKETKGLYRIHQFSKVEMFAYCTMEQAEEMMNELLAVQVELVTELGLHCQVVDMATEDLGAPAYRKWDILAWMPGRASYNEISSLSNCTDYQARRLNIRHKIEDKPQFVATLNGTAIAVPRILISILETYQEADGSVRVPAVLRPYLMQDCIRKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WIW9</accession>
    <name>A0A6G0WIW9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_014715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000200">
        <property type="protein sequence ID" value="KAF0727185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WIW9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000101"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009836">
        <property type="entry name" value="GRDP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07173">
        <property type="entry name" value="GRDP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0727185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="605" mass="67070" checksum="BDAD5C2F7BC8FFD4" modified="2020-08-12" version="1">MDTPTPTSAAPQHVVTAVPVVVDADKDLAKGDKFPTVEAVLIDDLPRLEVDFRVKKARAIGSDDWVWRQIVLHGQKLDVIHKNAIVETFSTVSCELNEAMSATRVYQIVSGGEPRLTFCCPSETLYNKFATVFRASRTTEFWTFPPVDLFEDLVSVAKMIVETEAGLQASPVKAPVVPASGVTVAQVQTHLANLKAIYDAFPHFDRQEELYEHVLAIEADFVKALEAKTAADHSPPLVQQILKLYPEIVWEDGAMSAALTLQLDLTKCPTCAKPFSVLSQIKFHVGGKTLVCGQCAQEAHYETFKIAQLRKEVPTFEFQSGLFKTARSMPLPDIPRDGKAKSYTDRLWRAVFEYETTKHGVPSKAKAALEKRIMACLNRLDLVQLIYRQLLFMAQIVAHFDYWNHPTVIQAAIHRYDKFRVVANAPKAQDLAATLDILLVGQTHQLTSSTAVLPVDKGSDFLLARLGNAAFVWGQAFNEPYSSCALESNEPLPATSGGGVVQDRFPRDKWAKFTRLPSRGNRFVGVHEVFAVESLGYNAEFAHEGVATAVSVIGALQVDARISRGKFRHLLPQDATRVYMYRYTTELPSLAEKIIGRLVFGVAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJ12</accession>
    <name>A0A6G0WJ12_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_014719</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000200">
        <property type="protein sequence ID" value="KAF0727189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJ12"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000104"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052050">
        <property type="entry name" value="SecEffector_AnkRepeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586:SF3">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0727189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="231" mass="25623" checksum="4881E9B2E2AD32DF" modified="2020-08-12" version="1">MDSLLQPWYAAHSTARLPLLFAAIRYMVNICVLHAVYFGHVDVLDQVHKFTKLHWFGYPLMDMAATAGHVECLQFLHGKVRRRCSRRAMFHAVRQGNLPLVHYLLETQEELQHAALDLAAQCGNLALVRMLHKMRVTATTQAVDFAAANGHVDVVEFLLEHRPEGGTDAALIQAARNGHLKVVKFLLDRHGTAFARAIHDAMDTAAGACHEPIVRFLRGVVAPSMIAPPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJA4</accession>
    <name>A0A6G0WJA4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Uncharacterized bromodomain-containing protein 10 helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_014572</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000198">
        <property type="protein sequence ID" value="KAF0727311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJA4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010199"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056522">
        <property type="entry name" value="KIAA2026_hel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23450">
        <property type="entry name" value="KIAA2026_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uncharacterized bromodomain-containing protein 10 helical" evidence="3">
        <location>
            <begin position="113"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="22"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="357"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0727311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="506" mass="60062" checksum="3AD7F27599C26ECF" modified="2020-08-12" version="1">MSDPDPSLMLWEKRKRVKPVIFQVETSVKKPKTRSNPPRKAVPKPSRNENKDKKSDGEVKSKKNRGTKQDESINSEDVAKFLNKSFYEEDGSEWHATDIHFDDLAQLRSMWQLPAACHILWLLQQPLKLKVFTTLREYEAALLNPATSPVLEDVFTKLLLGKKERERLNCGLGLSYEWWSKRLEEHYDERYNKWNLLKQKASQSSSDDDDENDIDLTDEELSTLNAMTLSLAPLGNQNPLKKCEFKRMEPRLRCLLLLNLCENVLQHPANMDYIREMQEDDLRVQPIGHDRVGNQYFFYPQFYRERRIYRMSRDGSTDSWQLWAKGLDAMQAMRDSLALILKKGRRYEGEHSLMDHLDAMLELMKQERIEEQKMEDKALRRAILEAMPRKRSVRIQVKTLEKLEDDKLKEEKAQAEESARAEQKRLEVLAAMEKEKELERKRMAELREQRLTLKIDRETRRQKRLEQEELQLEREAMEREFLLSQQLQREHRALQRQQMTSNDDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJQ4</accession>
    <name>A0A6G0WJQ4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">H/ACA ribonucleoprotein complex non-core subunit NAF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_014502</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000194">
        <property type="protein sequence ID" value="KAF0727481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJQ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021665"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000493">
        <property type="term" value="P:box H/ACA snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="entry name" value="Probable tRNA pseudouridine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040309">
        <property type="entry name" value="Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31633">
        <property type="entry name" value="H/ACA RIBONUCLEOPROTEIN COMPLEX NON-CORE SUBUNIT NAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31633:SF1">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX NON-CORE SUBUNIT NAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="236"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="308"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="371"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="390"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0727481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="417" mass="46851" checksum="27EA9167497FFAB1" modified="2020-08-12" version="1">MSDQHMDDVLVAAAYAGVEPIVDTIPITHHPASTQAPFGAVLATSSAAEEEGEVKDEVTVGQVDVTKEIVDQNMEGEESSSDEESEPDSDDEDQKKLRIEIEGALKKEEQAAAGPLVTAHEVKQLPIKKPNVELTPECPIAKMGRILNVNRAENAITIQSVPNQLPLDEGSVLCLTNRQVLGCVDEVFGPVSLPLYLIRFETAEDIPEAATLHADVFYATEHATYVQPEKCRVKGSDASNLYDEEPGDDEMEFSDDEAEQSAKRSKRKHPGNKQQSTEPRPPRQQYREPHHHQPRHFQAGYHHDHPPPPRPHQPYQAPPPYPPQYHQPYPMAPPPPPPHNAYYPDQYQYHPGQYQQHPEQQHHHHPGGPGGYPPPYPPPQEQYPPQQWQQPPPRPYNPNAPYPPYQPPQPPRSNYPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJQ5</accession>
    <name>A0A6G0WJQ5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_014479</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000194">
        <property type="protein sequence ID" value="KAF0727457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJQ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021642"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045814">
        <property type="term" value="P:negative regulation of gene expression, epigenetic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15504">
        <property type="entry name" value="PHD_PRHA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045876">
        <property type="entry name" value="PRHA-like_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12628:SF10">
        <property type="entry name" value="HOMEOBOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12628">
        <property type="entry name" value="POLYCOMB-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00929">
        <property type="entry name" value="ATHOOK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="12">
        <location>
            <begin position="335"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="415"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="478"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="206"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="415"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="495"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="505"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0727457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="518" mass="57758" checksum="52178AE7B8E46C81" modified="2020-08-12" version="1">MASALHHLLSPVEEPLPAPPPLPPLNKRARGKPRKNENNLLDAKTSSLQQLNGDVPKIAVNSGYNDGSSSNLPSSSFVQGSPGTNNAQESVPSCSMQAQKSKVDFLLSTPTPTVKSRGRGRPRKNFTHRTPSQMPLQDGSLEERETPQPQSVGGQPIKQGRGRPRKIRLDHPHAAQAPQAAKVVQSTKPPVHKKSRASARIMLRAQEGRGRGARERRAADHYSPNNLESKKRRRRQQRQSEPKTLGNPHVTRIVNRVRNRLSNMRVQLAFLDAYELEGWRNGAVDKLKPTAELLKVRNQLAHGKRMILRDLKDFDTVFANDKPLPKDVSELDDDEIVCSKCGSTTTTDTNDIVLCDCGPCHRAYHQDCLEPILAELPHEDEEWYCPRCDGVFKCLVMINSTFDEKWETMDEIFPDVDANTVDEEEQDSASEKGDEDDDEGDDEDPAEDEEESEEDVASLIIHGKRRRAVVDYRKLHGEMFPAGHDDDDDNEYEPAAATKAASASDESDGDANHEDEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJS2</accession>
    <name>A0A6G0WJS2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_014516</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000194">
        <property type="protein sequence ID" value="KAF0727495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJS2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001690"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0727495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="358" mass="41699" checksum="06BA4248E5CA9FE9" modified="2020-08-12" version="1">MLKGLTEEKEERQRQLEGKKVANRDFARSVIKLAHMDTSYVSDISLLSEKTKRQLECEELRKGLQRIDDEFRLTRNSIASEQDKKLKHQLLCDAKARRDEKSSPITTRLSELESMHPDISREMTLPHIHHTKQYKTTMDQIKSLWNAKKSMPDPLMADLEIGKLLMSLGDEDKAVAYMTNAIRPFENTRNSMVEPTEEEMKVIKKSEDSRIYEAHYLLFHYFLKKKAWSRCEVHMSAYLAKSEGRKRIDALTYLEKILKKYCDIVEVGRTTPQRINDVVLGSKSLGILQDLRVKVLQELNTLYPNDPYYLESLGQQYVNLHEYDKAKSLLDEFVKLPGISNLPTFAQVLEYKPQPRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WKR2</accession>
    <name>A0A6G0WKR2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_014183</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000187">
        <property type="protein sequence ID" value="KAF0727841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WKR2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005830"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF37">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0727841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="515" mass="58662" checksum="41B6C5997B7746A5" modified="2020-08-12" version="1">MQGHVDSALYVQATSEKCYASLLLKHLLVWIDDILVYAKDPEEYIQVLREFFGLVDRYGFKLSPSKTVLFTSEVKWCGCILSGEGVRQDPARIEQLCAIPYPTNAGDLQQFICAVNWIRESITEYAMTVEPLQQALNKALEGKAKKKRIASGIKIELTQEEKAAFDAVKSKMRTAVDLSHPRADATLCLFTDASDQGWSIIVTQVDKFDDELPIQEQSHEMLVCQSGMFTGAQKSWSVIEKEAYPIARACEKLNYLLMRPEGFRMYCDHKNLIHIFAPGKEWPEHTRGKLMRWAAIIGGYRYTIEHINGIHNLWADMMSRWGRPATGMATHKVLAARWTKKRKQPRHTPKRNTLRPLDEENFIWPCINDIVKAQAAHANTRPKEAKRTSDDQPWIVDGRLWIPAAAEDLIQRIMVVAHCGSMGHRGQAALVNHVKRLFWIERLNEQAGNFIAGCLLCPHVQGGRVVHRPYAPTWHAKRRNEGLHFDYLFMGEALGGSKYVLVLKDDLTHFCELVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WLE3</accession>
    <name>A0A6G0WLE3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RanBP2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_013959</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000181">
        <property type="protein sequence ID" value="KAF0728133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WLE3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018796"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052920">
        <property type="entry name" value="DNA-binding_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43358">
        <property type="entry name" value="ALPHA/BETA-HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43358:SF4">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="5">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0728133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="476" mass="52472" checksum="56F799CA8CA59E17" modified="2020-08-12" version="1">MGNSSQKPKRNADGPSRARSMSEGNLPSLENASVPSRTSSIPPPSAPQRNSLAAPPSGGIERGQEAVEETSQQLSYWYMVRHGYDQMVNLIIRPPRAEYSIEDLGPTSFLFSGQEFERVDFAIPVRREGIKNDLLIRCSQWQRAVSDRPKAADGNPVPLPCVIYLHGNSSCRLEALSILRCVLSTGASVVSLDCIGCGLSDGDYITLGYYERDDVQAVIEYLRSQGTVSSIALWGRSMGAVTALLHADRDPSIAGIVVDSAFANLDQLVHEVVEHGRREGYTIPTFAVKIVMRFIRSSVWKRAHFDLKELSPIDHVDKSFIPALFVAAHKDSFIRPHHSEALFAKYAGDKNLIKVSGDHNSPRPQYLLDSVGIFLQSVMCIDESLALHDPFAGAMLPWAHDSVLLARLFEASFDRAMNAVGEEGESELPQLPQTSWACRLCTFINPPGCTHCMVCEALHDPQEPRSEVENEVSQLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WLF8</accession>
    <name>A0A6G0WLF8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_013944</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000181">
        <property type="protein sequence ID" value="KAF0728116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WLF8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017180"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0728116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="486" mass="54718" checksum="30474524E178511E" modified="2020-08-12" version="1">MLMEHFHEQLVASAPRLLTVSDLPHILLQVQDSFPHQDDPLEAFEEAQRLLQSWWSSSSQSIIALMIAAVAVKKTGDSQGRAKFFHELQQPERLDTTVRTAAIGFLVNEPSLQEYMECDTSFIFQTSYFYAVIIHALVTETHVPSTDQIGRIAASLERSSPRLQLLWLDHVKQQTRAVVQALYMSYDAVLQHMPSDSLLPLLENSRSSDSERPHFVATVTTLSTTTAQLLDRVAAPSPSFLVGAIDILAWVTFLVQPENDLVNKAVRTIPPAQIPSVLAPLHESLKADQGRPLHLDVLRGNRVRFYLTYLSRNATQNLDTLFDLALVGAAHTLRPLHDLSHRILRVLARSGTSEMAVVYVRQMIQQYPDITTLGVIATGIGYILSRPDHDSALVRFYLAELYSTWDNNREANGDLARLIFELLKVVRMDDLGIALLFVEKMVWKDSTLLEQVYETISVACDAPRRIPLLEWFLRLQAQLAPLPSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WLH4</accession>
    <name>A0A6G0WLH4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline transporter-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_013994</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Choline transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000181">
        <property type="protein sequence ID" value="KAF0728168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WLH4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016680"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF4">
        <property type="entry name" value="PROTEIN PNS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0728168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="488" mass="52803" checksum="F5C578D73504EDF6" modified="2020-08-12" version="1">MDVYKAMDADVEEAFLPGNNHVSFESKDKIPAAIFLANVGAVAYMAIVWGGPNVSKFDFTDHKADETTRSQAMTLLIVSLGIGLVGAVLSALWLQVLQLYASRMISMTLQVTAASLALASMAGFMEGGFAGRAIGFLNIILSGVVVMYYFNARHRIPFAAANLAVAAKIMRRFPQVVIVAYGAIAAQVAWMLLWTVALVGVWTKAYDIHASSMELLSTATLNLSVFFMLLSLFWGLQVLRNIVHCTAAGAIGEWWFSPDTTHAVQRALQRATTTSFGSICFGSLIVATLSALQFVLLSAKRRKGRSTVNACLECLVTALETHLRAWNKYAYCQVALYGKDFQTAGTDTLQLFREKGWSGVVNDSLVSSVLSMGCLVVGTATGIVGVTWFYVATACSEAEMALHPAQCETFNVIMMTFVSCGAMGYAMCAVVSSILDSIVATIFVCFAEDPVALHITNSDEYIAIIDAWRQFHPELLTHSTFSASVSYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WLW2</accession>
    <name>A0A6G0WLW2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_013827</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000179">
        <property type="protein sequence ID" value="KAF0728276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WLW2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017240"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011666">
        <property type="entry name" value="DUF1604"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384:SF19">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07713">
        <property type="entry name" value="DUF1604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0728276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="592" mass="66008" checksum="04BF490DB9AEA5E8" modified="2020-08-12" version="1">MSNLQKKREDKRFHGAFTGGFSAGYFNTVGSKEGWTPSTFQSSRGQDVSRKQRIEDFMDEEDDPLLGKRLELSSKYDSSAQDAQSKKFQTQQAAENVPIPGFVVDDFIQPSKSTIGTTLLGKMGWKPGQGVGPKVRKRKFSRFDDPDDNTVLIAPKHNINIADFFPAQKNDKYGVGFDPFVNAPEFGFLKRQQEAASKQSNSRAIMTFADAIRGSGGNTMGHGLSALEEADDLDIYAMDTKESFDRVLSKAPSTASRAMLTAPHDDEDRPAPTQFCSDGTPVLTGFKLSSTRHKPPPVVLAAINVPPNWTPTLKHLRLAPPRKQRPMTAAQRGEALGEVSKQPAPPAPERQLLHSQFRAGMLAAISNRFQKASSSTDESTAAAPIARAIEPLVRQTRPFMPDKLLCKRFRLAVPDAPAEAPTKSSVNVRFENDILAHVPAGAASNEPVADASKEQLPELPPLERPPIDLFQSVFENDDEEEEDDSSSSSSSSEDEEETKTDKPQGAPKEPSPNQKDNKKEEKQDDRERRQSSPDRYRDDRKRSHRDDRDDSGDRDDRSRDKSKKSKKEKKEKKEKKEKKSKKHHKHHKSSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WLZ6</accession>
    <name>A0A6G0WLZ6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Acetolactate synthase</fullName>
            <ecNumber evidence="4 11">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ae201684_013858</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2 pyruvate + H(+) = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="11">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="4 11"/>
    <dbReference type="EMBL" id="VJMJ01000179">
        <property type="protein sequence ID" value="KAF0728307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WLZ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015669"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02015">
        <property type="entry name" value="TPP_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000008">
        <property type="entry name" value="Acetolactate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000007">
        <property type="entry name" value="Acetolactate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012846">
        <property type="entry name" value="Acetolactate_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039368">
        <property type="entry name" value="AHAS_TPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00118">
        <property type="entry name" value="acolac_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF13">
        <property type="entry name" value="ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="14">
        <location>
            <begin position="34"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="12">
        <location>
            <begin position="229"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="13">
        <location>
            <begin position="429"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF0728307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="611" mass="66723" checksum="3F62C827888F5737" modified="2020-08-12" version="1">MMRRFKSNLSPVAAAAATAAPTYVKTEEYIGDSGAKIFHKMMQHMGVDTIFGYPGGAILPVFDEIFESPHFKFILCRHEQCAGHMAQGYARATGKPGVVLVTSGPGATNTVTPLQDALMDGTPIIVFSGQVASHVLGTDAFQEADILGITRPCTKWNVQVRHVNDLARNINEAFHIATTGRPGPVLVDLPKDITAGICQSSVSTTPQLIGYYGEDKVLGNRRDQSANLHEAARLINASKKPIIYAGQGTQHCSEQLRELAIKMKLPVTTSFQGMGAFDETHPLSLHMLGMHGSAYANYAIQEADCVIAIGARFDDRVTGRVRDFAPEARRAGRLGHGGIIHFDISGKQIGKIVPTNVGVVGDAAYNLAQLLPQLESKPRTEWHDQLQTWKKQYPFRYRNQPNGGLKPQRVIEELYTQTKNNDKVIVSTGVGQHQMWAAQFYRWRRPRSLISSGGLGTMGYGLPAAIGAKVAKPDHIVVDIDGDASFSMTLMELATAAEFNIGVKVLLLNNHAQGMVKQWQDLFYEERYSATIMKNPNFVKLAEAMNCKAVRCSSQEDLAEKMAEFLAAEGPVVGEFIVDGDEHCYPMVGAGKALDEMIIGDFDDCPPTTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WMF0</accession>
    <name>A0A6G0WMF0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dynein axonemal light chain 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_013672</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the dynein light chain LC1-type family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000176">
        <property type="protein sequence ID" value="KAF0728485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WMF0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003920"/>
    <dbReference type="OrthoDB" id="266138at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000049">
        <property type="entry name" value="Dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454:SF73">
        <property type="entry name" value="DYNEIN AXONEMAL LIGHT CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0243">Dynein</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0728485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="188" mass="21081" checksum="6BDA916BD9F8FB69" modified="2020-08-12" version="1">MTTCSQAIKAWEAKENASSEEASVVKLYCQIPPIAKLDNSLNTLKNCEHLSLSTNCIDRLIPLSGMKKLRILSLGRNQIKKIEKLDDVSDTLEELWLSYNAITSLDGLSGLSNLTTLYLSNNQIKNWDELDKLSNLPKLRDVLFTGNPIYDGLSKEDARLNVLKRIRNVMKIDGDMVKQTERDAVAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WP82</accession>
    <name>A0A6G0WP82_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_013135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000167">
        <property type="protein sequence ID" value="KAF0729157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WP82"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011572"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0729157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="17081" checksum="C756CCAEB986A0C5" modified="2020-08-12" version="1">MPPRPCQGHLVLRLAQCVLCGVGFLLSSTMTHAVAGCFALVMLFLLTFASGVYSVYIVRRQTWKPSQSIKWLFEIVFLILLVTCFAVLSATSSLFTCSEATCTWAYIVCIVVALSSLLQVLFIYDLYKTPKPVLAKQQSHTELETPQYPLEHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WP92</accession>
    <name>A0A6G0WP92_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SUI1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_013144</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DENR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000167">
        <property type="protein sequence ID" value="KAF0729167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WP92"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011582"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11607">
        <property type="entry name" value="DENR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050318">
        <property type="entry name" value="DENR/SUI1_TIF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046447">
        <property type="entry name" value="DENR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048517">
        <property type="entry name" value="DENR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789:SF0">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21023">
        <property type="entry name" value="DENR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUI1" evidence="3">
        <location>
            <begin position="226"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="101"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0729167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="317" mass="36119" checksum="54DC2AF7A21B34F1" modified="2020-08-12" version="1">MTTRARLERFYSKYNPDKKGEIESVMEKYKGRETALFEALVRKYGPEPDANEEITFVDAMTLRLQAFYEKYNPDKVAEVPAVLSKYAGKEKQLFEALVKKYGPEPGDEDEEDDDDDDDDDDEDEEEEEKAPANPLQREILYCPIDNLPPEYCEYGPMFNECKPWLVEHVPNLFIQKYNRTISELVEVEAQIAAGVEGVTLEAEGSKSVKKKKAKASESDGKSGGNVYVERFQRQKKKFVTVVAGLDDYKGIDIKDVAKRMGKKFACSASVNKLDNGKAQIQLQGDVQQELPHWLVEEFQIPEENLFLLEKGKSEPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WQE3</accession>
    <name>A0A6G0WQE3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">Ae201684_012864</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000163">
        <property type="protein sequence ID" value="KAF0729597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WQE3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008968"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017171"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0229">DNA integration</keyword>
    <keyword evidence="15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="13" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="14" id="KW-0917">Virion maturation</keyword>
    <keyword evidence="16" id="KW-0862">Zinc</keyword>
    <keyword evidence="16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="18">
        <location>
            <begin position="212"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="19">
        <location>
            <begin position="517"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="241"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="247"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF0729597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="22">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="607" mass="68260" checksum="02B71361A5B47589" modified="2020-08-12" version="1">MADKYTIDSTTRLKPDGSNYGEWCVKTRAKINQQKLGKYLKKVQMENGQYPIGFNEEDDLAALSYIQLSIHTDHLKFVKDTATTYEAWESLKAIYESASEIYLVTLQIQMGKLESNDCIGLDTFADQFQELMRKRTAAGDTTPDKAHLNRFLCLLPPRFANTVIYITRERRTSTAILAELKLDDERQKLHDPNLAMRANQMDDALTVGPNDCRYCGKTGHYQVECRKKTADIQKGIYRRTIKDHPNRGGRGRGRGRGRGRGRGGHWQNQAEGYNVDGEKDRDADLFMVQKFQNGSESCGQEWELLDRELANYATRPSHDECNTTTSPTSIDVIVDIGATCHMTGDESILHEVSSCTRGVRLADGHSINVTRMGDVKMKSWDTGRTAIFRNVLLVPTLTKTLISIGRIADNEGKTSILFKHDFCNIKAGSNLSIMGKQNTARLYVLRGDIIKPKTRLDKAHAADIMLWHARLGHVPLKSMIEISNATKDGPTDLSKQRSILCEDCIRGKATLSSAPKQGDRPRHNLGTCVHADLLGPAKVQTPIGAQYFVAFTEDATNYVWVKFLRSKNETFEAMKEFIPWMERQTGTKLKTLRSDNGGGFTSDEFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WQJ2</accession>
    <name>A0A6G0WQJ2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_012744</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000162">
        <property type="protein sequence ID" value="KAF0729683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WQJ2"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0729683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="129" mass="15181" checksum="B6B0A0AF3FA3A9E0" modified="2020-08-12" version="1">MFKARLVMAERKCRSHTETLLAAACCQSPPEKIVHDQICYRYVAKPSLKRQSSIVGGRRVPYFRHQLEQIRQKRKYLDGLNTIDETPFECEQCHSNVISHQVPTVTLTHWKSHIKVHQRWTQNRTRGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WQK0</accession>
    <name>A0A6G0WQK0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_012745</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Folate-biopterin transporter (TC 2.A.71) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000162">
        <property type="protein sequence ID" value="KAF0729684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WQK0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003394"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039309">
        <property type="entry name" value="BT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585">
        <property type="entry name" value="FOLATE-BIOPTERIN TRANSPORTER 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585:SF5">
        <property type="entry name" value="RNA-BINDING S4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03092">
        <property type="entry name" value="BT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0729684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="40198" checksum="CBE85F43F7218914" modified="2020-08-12" version="1">MNPNDKMDLEERLSYATSTKGKDGEYTELKTPGELEDAFGLYSQYFAIGIIYGLIPALNYPIFNFYLQMEGYQTASYSVLVNLGWSYKVLFGMFSDCFPIFGYRRKSWMLIGWSVAMVCLAVMTFSSLGDPYCNWMTEYKDYCNYCKLPLEKVPKEIQAKNYDFDAPNRGSKFIILSMLVSFGYVTAACASDAMVVECAQREPIAIRGRAQTAIYVWRYIGSIIAVAVPAFGLNGANYNGSFSFSMAPNVPYGICLIPCVMVVLTTIFVVVEKKSPGIPLKTWVSQFWGLLQQRAMWQICAFRFINNVFFGIATTASSPIEAWWAKVEPLNSSLANMLGKGFFAISLAVVGKYGLHWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WQY8</accession>
    <name>A0A6G0WQY8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_012616</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000160">
        <property type="protein sequence ID" value="KAF0729833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WQY8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019934"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
        <property type="entry name" value="FYVE_like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="5">
        <location>
            <begin position="279"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0729833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="355" mass="40037" checksum="02FCF086D5AA44F2" modified="2020-08-12" version="1">MLSANKAKKSPLPSGFFQCPPLSPDDVQQLKADAIQSAMEVVMKSQLDNPRIKWTLRSDEVDLTIYRADDPSPGTYLYLSQMDVVGTLDEVGQLFLAQTTQQAKAVALRFGKEIFDAATLYSLVKPTLQDPLEFVGVTWKAYKSPLPFVAKRDACLIECCHSFLLDGRRGWVICTKSVEIDGCPEIENFGFTRMMNYGSGHVFLESDRPNHLEMRYVAHLNFRGVSYDEFSDGMLKRRDIVGDIAMTKRCRNLTAIDQFLREDRLARGHVLRPEEVVPQDLRPRCFLCDVRFGWTRQKSNCLKCGQVVCSSCNRVWRLVVNGRQVRLRACARCALSPAKSNASQMSTVLSDASSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WR67</accession>
    <name>A0A6G0WR67_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16">Phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="6 16">2.7.7.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Ae201684_012533</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 16">Belongs to the CDS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="6 16"/>
    <dbReference type="EMBL" id="VJMJ01000159">
        <property type="protein sequence ID" value="KAF0729892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WR67"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005000"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016720">
        <property type="entry name" value="PC_Trfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773:SF8">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, PHOTORECEPTOR-SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01148">
        <property type="entry name" value="CTP_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018269">
        <property type="entry name" value="PC_trans_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 16" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14 16" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15 16" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR018269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF0729892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="423" mass="48381" checksum="7E34AD3EF56378E0" modified="2020-08-12" version="1">MKRRSVNTSSEDGPTPAPKEVGTPPASPASTMKHGVPLGEDVTKPSMSIIKRVVAGFSMIGLFCLIMYGGHLYVTLLVVVLQTLIFRELVNVRYRVNAEKNIPWFRSIQWCWFAVALLFNYGDSFQAFLRSNRNQLDFPWLRMYMQYHTWVSFSLYALLFVFSVLSLKKGYYKYQMGQLTWTIVILALIVFQMRYVLDNIFRGLFYMFFPASLVICNDCFAYFCGKLFGKKFIKTTFLKLSPNKTWEGFIGAFLCTLVYAFFSSAVLAQYSWMICPLETIQLVPRDLSCKPHPVFTKTWYSLPPSIATFLDIPKVQLYPIQLHAIVFACFTSVISPFGGFYASAIKRAYKLKDFDSVIPGHGGFMDRMDCQFITALFTTAYCATFIWSYDTTVQAIIQSVLQLPLDQQLQVLEQLQATIAPHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WSQ4</accession>
    <name>A0A6G0WSQ4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_012166</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000154">
        <property type="protein sequence ID" value="KAF0730466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WSQ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015925"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="119"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0730466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="232" mass="26326" checksum="14734DD0BFA7BE04" modified="2020-08-12" version="1">MTEQRQPKRQSSHQDDDFNLSDEDEESESCDTDDEEFVAPDTGVKRTSRSESFEALTEKRRSKRTTMPPQAWWQVAQFTHFAASVGDHLPKTYKAAMESGNAGKWSEACKAEIKSLLENKTWDVVELPEGRKAIGCKWVFKIKERADGSIDKFKARLVAKGYSQEYGIDYEETFEPVAKFTAIRVLLSTAAKYNIDLQQMDVNTAFLNSDLDEDIYMQVPDGLDVKATQGQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WTI0</accession>
    <name>A0A6G0WTI0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_011879</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000151">
        <property type="protein sequence ID" value="KAF0730770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WTI0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010359"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010736">
        <property type="entry name" value="SHIPPO-rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF408">
        <property type="entry name" value="OS09G0560450 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07004">
        <property type="entry name" value="SHIPPO-rpt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="155"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="207"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="293"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="351"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="407"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="610"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="729"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="822"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="634"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="729"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="756"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="773"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="822"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="840"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0730770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="869" mass="93241" checksum="B8E3B0B149735EB9" modified="2020-08-12" version="1">MTRRRRSVNQHDDDETSSNGSDSFRSLEPSNSSRRLLCLSSSPSKSVLEAMSLSTSPSKLMSRQRSTSLMRSQMSSQALLVPPSVEIAPKTQPSASLMNLKLYLFGNAPFLVGAMATTRAQANLPSHDITELFPAGQPLAKLSAGYEWGAALVHNHVHTWGNNTSGQLGHGHTDAVAHPTVISSLLHIQIVKISCGSAHGGFVSDEGELFMVGDATYGRLGLGSAVSTVVSTPQKVSWSFADCRKKTLELGMWPFGYDEKADDPSTTATFFSDVSCGDRHTLVLVKQMHTLRQVLLSFGDGSNGRLGVGTDIDHWTPCLMSHFHTAAGHAFPPIREMTAGVQHNACITHTGEIFTWGYGAHGELGHKTQDSVWTPKRVEFFFEHGNFIVAKQAACGAFHTVAVDTAGRIFAWGRGDAGQLGVTLSTAAIAPSPLEISFPKRTPPITARAVAAGRQHTLVIDSLDNVHVWGSNRVGQLGIKEMEGGGGGAAEGVPPTQWTPASMHFPANCPPIHVYVKQIVAAEDYSMVVLRAANAFESSREMDRARKAAAKIKMLQGKKAQNAPSPRKAAAAAAAATWSFSVTEPTDELDIPSQVDRFVAIMAATKLAKRPPSAVKSGVHHAPESSPTASAVSKPEHAVVRAEKRRLATPNKGDQTPIRGLLQWRAARFNKTPSKRTTTFGYKSRFPIHPLVESSSHPQESAAAIPTERQKKRSVWRNAFGVGARFASLPSSTSKVSTTPGPGAYDIPKSSPRKLTPSSASFGSKSVPQHPLPVAAPSNNPESAASVHLDRANPWIYPTPPSVKFGSSDDFSKVIHKRLAAAGARAMPGPGTYDLDQPWTKPTKSWKSYQTPSKSSKSPPKSPSRHEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WUJ2</accession>
    <name>A0A6G0WUJ2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_011673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000147">
        <property type="protein sequence ID" value="KAF0731130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WUJ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009608"/>
    <dbReference type="OrthoDB" id="70757at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0731130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="251" mass="28701" checksum="D3FA1E66C2CC5756" modified="2020-08-12" version="1">MMKGLPSFDFDVHQEWIDLSLADEHEDSEEERRNWEWFQVSHAGHASPRKAPHPKHTIAAKSKPVKGKEEEFVKRMLMEHNAKLKNARLSERSSHGHHMSSHKANSARKSEERKSSLECAWHAVPQGSVTRKQSRETLGNIPEQSDVHADENDKTATSGRRKNFISPGLAASNSHQSPDPTRAQLLSKSPREDLQDMLDELKSKQPTSQALRVASSDTKQSVKRKLPREQLELQLLVQQHNDKHKRRHSNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WV56</accession>
    <name>A0A6G0WV56_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_011316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000143">
        <property type="protein sequence ID" value="KAF0731413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WV56"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007452"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0731413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="420" mass="48810" checksum="F8FE2660C2A16598" modified="2020-08-12" version="1">MSSHRRILHFRSLLTVIIVKVAFFLPNWTAVTKYIKALRPADLLVPLEHLWQLHLLGWGDDALWPCLNITGMNEDSRVHVEAIASYYSRLGVDPKTDVDWFRCYADPAAKVWMKATSRTGFDMTIVSKWKQTRIFWFELTVLKPDQFLEALSYLQHLEMIYWPHCTPELTMALCQYAASSSSLVDLIMETESHGNGHCTITTSMTDALLKWIEARPINLFSLENFSWENQKLRCAVVEAALKQEMLKHFTLQETNETNYRFRADYDTEKHQLTLDFFNAILDLLVNFNNLSCLTNIFRILIQANVQKFCLTNLQEVDFEPIWMIVGPLLENSKVEVLEFNHKVYSYYDAIHIAQTMNFCITFQEFLLRDKPASLAENLTVVNRIILQMRRTCIVPLLEELKVLETLVKKDVDYSCALLGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WVJ1</accession>
    <name>A0A6G0WVJ1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_011160</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000141">
        <property type="protein sequence ID" value="KAF0731535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WVJ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011671"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="NUDIX_CoAse_Nudt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992:SF11">
        <property type="entry name" value="MITOCHONDRIAL COENZYME A DIPHOSPHATASE NUDT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="7">
        <location>
            <begin position="118"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0731535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="295" mass="32745" checksum="8D8AF9B22995E9F2" modified="2020-08-12" version="1">MSRARRLWTTAVHRSLSNKALKLPEYPFDPSELVSQYTAPALAAAFSDREQTLRRCAQLLEEGDIQQLSEILTPFRAQSAAKDAPTTTALDEAFTVRHLDRIKKRLNRLPRQIAKVSQKRAAVVIPLCTMAGDKSPHVIFTLRSSQMRHHRGEVCFPGGMVDASDTCIENTCLREMEEEVGLPASHVNVLGILRCDWSNVASITGVAVTPVVGHIDSFDESTLQLNENEVECLFTVPLSLLVQDNYWIRPKNATPVFTAGPHLIWGLTAYVLDICIREVLLVEASPPEDPEAHVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WWJ4</accession>
    <name>A0A6G0WWJ4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_010946</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000139">
        <property type="protein sequence ID" value="KAF0731845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WWJ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013185"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0229">DNA integration</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="12">
        <location>
            <begin position="68"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0731845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="544" mass="60867" checksum="71AAE9638F79855C" modified="2020-08-12" version="1">MVYQPQRTLQEWHVALGHLNKPAIIKMVSDSLPEHMIVTRREHDLKEPCLECAIGKQTRSKQPTQDTSDSSPTEEIGGVIASDVAGKITPTDRYGHKYFVNYVGHASGFVMTYPMKKKSEQASKAMEFLAEFETSFGTKVKIFRSDRGGEYLSEKFTTYLATKGIRHQLTERNSSASNGKAERMHRALLNATRTMLFACDLPAKFWSHALAYATYLRNRSPSKANAEMQSPLAILTGKPPSLSHAIPFGATCPVRIESTSKGIKRRAEIGRVLGVNAQSKAYDIWVTRIGKVITSKDIQNVGRPRNRTITTEDEQLLTEMSKQTDEEAPTKTADALKRSQTKLKKLEAIAKDHERKSPEPRRLDRIHKMQLAYGGHVALVMTIADPKTPEEALSGPNANMWRDAMIAEIENLIENGTWQLVDRPTDTNIVSNKWAFKVKYDSNGDVEKFKARLVARGFSQQYGVDYTETFSPVIKLQSVRLILAIGTYFNEELEHLDVPQAYVKAGLDTDVYMEIPALVPGDPATQALKLIKSLYGSKQSGMQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WWV5</accession>
    <name>A0A6G0WWV5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative auto-transporter adhesin head GIN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_010709</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000137">
        <property type="protein sequence ID" value="KAF0732056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WWV5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015184"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021255">
        <property type="entry name" value="DUF2807"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39200:SF1">
        <property type="entry name" value="AUTO-TRANSPORTER ADHESIN HEAD GIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39200">
        <property type="entry name" value="HYPOTHETICAL EXPORTED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10988">
        <property type="entry name" value="DUF2807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Putative auto-transporter adhesin head GIN" evidence="2">
        <location>
            <begin position="172"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0732056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="398" mass="43007" checksum="52A16CBEF5AACE1A" modified="2020-08-12" version="1">MGLQSKVWTAIEPVKGLSFDLSGRVFVHRSPSHPVAMTITLMSDSQALLDVIQPELSSDWKGRLIVTTAIRLPPNSNVQIDANLLAHVVVREPLSYVSSEAELVLHDGALASTSDESVTLKANDRGCVLYNTSASMELHSLSLDANDDATIQILTPQLSITDDITLKANDGGSVGIQSRDLAAHSLTSSADDGGSIFVASDIRVALLDTDIKDDGQVNLYPRGTCDDSSVKVSDSGNANLGSIACGSVDAKISDDGRIIVQALNTLETHVSDNGVIKFYNTTPLSFSSASGQSKRRNAQFTSSNPFNLLELKALPLDVPTHVQILSLHGDGPLTTITRSDTPEHAFQTDRPLPIARHRDMFDGLWLVVLFIVLFMGYTWCKPPKKTTEAQPLMLVRYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WX45</accession>
    <name>A0A6G0WX45_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_010717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000137">
        <property type="protein sequence ID" value="KAF0732064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WX45"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005722"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0732064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="359" mass="41144" checksum="64243206FAD40957" modified="2020-08-12" version="1">MSMPDAVVVAMKRPLEDPEGQQPVKKRRSLSKAGLTEEHQLELFLGKIRRQIQEKFGIDAAQMCHEDRNVTISCWQCGKQIKIATGHIHLRSMNSHLERCKGSAAMMPKPGEEEQKKSQRRSSKKALSEENLGILFLENARRQLKEKFKVDNVTMVHKGRNVCISCWQCGKAVKIAGGRLNLSNLKAHLDRCKPCKKPKRVLPAQPAAVNQFLCAGLTSDEIRNYCSNAMRMFGGCQRREEILKKLFNIRSFKNLTEEQLEEFQKYEFSTRKWNIVGTTVFSVECTKVSAIGKTCHECLSLYRNKNFVNTLCKYRARAQKLADGVINENYVKYIPRMYVQHPGAKLAQSFENQRFKTII</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WXV1</accession>
    <name>A0A6G0WXV1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_010522</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000134">
        <property type="protein sequence ID" value="KAF0732413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WXV1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010750"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF214">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="73"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0732413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="344" mass="37983" checksum="4FD68A514EC77EE1" modified="2020-08-12" version="1">MTNRVALIAAVVTAVVVLLGLTTLLIVRRRRRDAKDNYNQPAPTKTLTVDEMSSALATNAASYPELLQLRLDANGLQIWFEFQRSNVWRAEYNSRAVAVRRMRRGDLHFAGEILAMSRLDSPHLVGLVGATWTAPGDLAAVMEFVDGPLRDLLSDSTVAMTWAPTKVAIALDIARGLAYLHSRRPKVFLRELTSRHVLVSHDRTVVKLNVFQLLSTRERELTARMADMAWMAPEVLADDKEPTEAADVYSLGVLLTELDTRKRPLDEIKAAHAKASGIVAGTLRPALSPSCPPAIQRIVEACLNHEPRLRPSSTKAMTMLEEASKDIVEPKNAQTAPPSKSDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WZ61</accession>
    <name>A0A6G0WZ61_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_010143</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000128">
        <property type="protein sequence ID" value="KAF0732813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WZ61"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013123"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052993">
        <property type="entry name" value="CFA-57"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32215">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32215:SF0">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="322"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1035"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="511"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="565"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="727"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="921"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1001"/>
            <end position="1028"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0732813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1060" mass="121792" checksum="53885ED84A135922" modified="2020-08-12" version="1">MWTWEKSKVITTFKAAAQYGSSIGQVDFNPQDSTTICASGNGTIKFFKFADGQLRQQAISLKREPGNFLCHCWLPDERLIAATLSGELWLFENMEFRAALASSPTEGQYCSSLLAYSKGGVVRIYEKSDDSREHYKRTKTFTIDGNPQCILNLALSPSEDTLICSLENNQLYMLTLSSTDILKEDAMNFELVSTPFHRPGANGTQITGLDTCIRKPLIVTCGVDKSVRVWNYNDKSTDILKFFKEEALAVALHPSGLHIVVAFTDKLRMLNILMDDIRPYREYGVKACREVRFSHGGQYFAVANNNTIQVYGTYSGELMAVLRGHTNQVNGLLWKNDDRKLVSCGSDGSIFQWDLRSAVKVGEGHTHPRCNYSDLCSSTDANLVFATGTDGTLKEIDIVAGTLRLEHNSGVVLGPLALTTSQQYLFVGTVEPRHPGCVRAYKLPLEAESSYSEVQCHDLAVTRLRLSHDNQYLFSVGEDGSLCIFETKELTSSKLKGRSERENAMAFAEEILVTKSDLEEKNRTMQELKAKVDELTLHNEYQLRLKDMNYKEKIQEVSDKFTSELTQDKQRCADLQEDKREMEAEYDSKLSDLETAHSRELEEIRETYEAKIKAEVERYEALIQERDEENARWEEENQLLVESHTQFLAEMTSEYDRKVEGEQLKQTRLGSEKEEILHEFEVGKKHIEEDADLEVEEVKAKYDAKFLEEREATLRLKGENGIMKKKFTALQKDIEDQKEEIRSLQEKGKELYENIKGLEKDIQGHKKEIREREETIQDKEKRIYDLKKKNQELEKFKFVLDYKIKELKRQIEPRENEIADMKLQIEEMDQELEHYHKSNAALDLMIGELTLKMDGMQKDINHQTLEIKTMRQFIKQFQGDLHESAQLLEKKKALKLSIIALYKKYENGKIVAEVESDVDAQQEYNRQREYLEKEVESMKNKLVKGMKINHSEMMRLKRENAILTIQVNDLRREFHAVKASQNEVNDLKNKQRDKRTVDEGDMQLRRESELQKAQIQQLKNQHAALQKALGGSNIAAQPRRSLGNSNNSKLAPMKGVHIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WZM7</accession>
    <name>A0A6G0WZM7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U2A'/phosphoprotein 32 family A C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_009885</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000126">
        <property type="protein sequence ID" value="KAF0733063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011007"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050836">
        <property type="entry name" value="SDS22/Internalin_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003603">
        <property type="entry name" value="U2A'_phosphoprotein32A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652:SF3">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00446">
        <property type="entry name" value="LRRcap"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="U2A'/phosphoprotein 32 family A C-terminal" evidence="5">
        <location>
            <begin position="880"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="domain" description="U2A'/phosphoprotein 32 family A C-terminal" evidence="5">
        <location>
            <begin position="1377"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1415"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1453"/>
            <end position="1515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1530"/>
            <end position="1575"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="314"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1424"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1453"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1482"/>
            <end position="1495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0733063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1575" mass="178776" checksum="CA17D84514982A70" modified="2020-08-12" version="1">MSNTVNEQLPEKEIVEQPTNDPVDLSPELDIEEDDSNERLEWYNSNPDLEEFCTANGLTRKQFLRRCDRITSLEMFLGFWPTMQSVRFFGLLQHLSIVKHPTIATIEGINACPFLETLHITECSLMRIQNLDNCTKLTQLNLSSNHLEKIEGLSFLSALEVLWLNDNQISIVEGLSSCVHLKQLWLAKNAIETLDTSLDHNQELQDINLAANRLNSFQTLGSLHKLPLLRSLSLGDPHFGDNPVCRLCNYQTYLLCRFPTLSYLDTIELSSSNKQVADTTLTKKRMYYNMRIKTIKRHASDCIRSARTCYSDHINYANFNLNALMRELSDLEKELHADKTSPFPQYAPGALATKRDRIHAHIQQKMRTVHAMTTSFEALVSRVALLSEKTIQRLMLELHTGGNIRLEDGKPSDVWYVSCVDLVKSRSFVHDMQLFGVAELKVNRVTRINHRYLRNRFQERMEEIVDGPEEQVKDNVSKRGITVKDTQEDRSNIVAREDIAFENGLEYLFYMQPPILDHMSAAQSEQDFAIQAGLRPLHEYVGVADSGIKLTNSLAALDLPRLATSLHVKGQDRIDPVEITKLDQFGWDKPPELSLAMRSSFRKLLAGDWRLPNGHVLIAKVFLGRVRQVDSVPCAKDHMDGIQCIQVAKPSDPKQRCYYLLDEALILPEYLVEYEYILEGAIKQPVTVSPRRTNNSSDEALADMAEAFAITEGFQAKYKLTFAEPLLDQHLLEETTKALIQMEPTTPRRQTMGMSQAITPAFILDSSRQKELSNICELNLTSCGLKSLQGFENCNLTHLETLILSFNELRRIECLDGLKSLKFLDFGYNILRSLDNVSNLVQLKTLLLNNNLLYRFEDVRSLSHLQVHTLDMRNNAICDAKRYRLHVIQKLPQLTTLDMGAVTQVEAQAARELCLELTPLKIWACSRGKHLYNHSSALEIYQTQYLKRKPREMVEEGISFDEDGSWWKDVDELHVNHELLTKLTHLDKLRNLRIASFSDNDITYIDGLSQCAHLEELIMENNQIMSIENLESLVNLKVLDLSKNKLTSMKNLDALVNLKQLSVEDNEITSLQGLSHLVRLMELYVGNNRISYLKEIQHLKTLPKLIIVDFAGNGFCSEPEYQLYTIYHLRRIKVLDGSSITAELQNEAKQAYSGKLTTDFLVEKIGHAFNRIQEMELSSCRIREIGSLHGDVFVNLRDLNLENNLISDISGLEKLPKLRVLNLSSNKIDRLTSAGPGTGILACPKLEVLQLARNLIADMVNLSLQHVPELKILNLEANDITSIVGLAALRELKELYLSKNKIRQFDPQPGANMSNLVLLKLDDNSLRTLMNFLPLQRLQVLDLSNNRLADMEEVERLHHLLPILQEMSLLNNPLCKRHLARSTIIFRFPTLKTLDGRDITLEERERVDVLFMHDRSLPNPTLPPSIQASPMANSNKASVKLTAMSFDALAANQSRKSQNNNGVTLFPQVPQQQMPPQGPGSTRDEKDKSKDDAKEVRRKNPALPDTLLSNHPMNSGLSNMLTTSFASFSQTKGMSRPGDAMYSSNSIVPPKPTYLAQPTGHVLTNRSSRNHGPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WZN5</accession>
    <name>A0A6G0WZN5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_010072</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000127">
        <property type="protein sequence ID" value="KAF0732966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WZN5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021714"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17671">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006816">
        <property type="entry name" value="ELMO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050868">
        <property type="entry name" value="ELMO_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004012">
        <property type="entry name" value="Run_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037213">
        <property type="entry name" value="Run_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771:SF56">
        <property type="entry name" value="CED-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771">
        <property type="entry name" value="ENGULFMENT AND CELL MOTILITY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04727">
        <property type="entry name" value="ELMO_CED12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02759">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00593">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140741">
        <property type="entry name" value="RUN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51335">
        <property type="entry name" value="ELMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50826">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RUN" evidence="3">
        <location>
            <begin position="89"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="391"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="ELMO" evidence="4">
        <location>
            <begin position="658"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="585"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0732966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="966" mass="108242" checksum="542195345F6E64F2" modified="2020-08-12" version="1">MDLWRQLSSYLGSPAEVEETPEQKLNRERRQAKLRLLSRSQRGVILDDLKASVAEVLQLVLDHQKQASSIVSATMESTDDTHNKVLILNDDLPPVSKLCANLDRCFSHGLRRVENDDQQSVKFFGLLKWTCTRLGAIHQQRMACGIDGAGSANFSKTAVQLATSSLEPELPRNVRGFLACVRTANDLSNVNLDEGKVRAFIRQALNTHILLDCMRVTLSEANSDLLVSYFTEHALFRQQDEVEIFLTLLDGLETLSFGFLVNDPRLDLSPDIQPFATPLPKPVPQVAGPPPADLIDPEDMVQGRVRLSGEDYECNLLAAKLMSHRQLKAEFDKSTNGNPLADVLLKAKTSHALDDATSAVLRFLEIGLPEYDVFGAPLLEVVCNPFLCGLARFDTSLGLPDVVEACVCYLHRKLTTPGLFQVHLASEHVLDLRDAIEELGGFHKSMAIDPHEVISVLLQYLWELPEPLLTEDRIEAFLAAAKSPDDKQAVRNLRLLVNDLPWFVKPLLERLLHLLSRALEHSAKNGLTLQSISLLLAPILLRPTRPYRFSELDEPSTRRFPLAGHVPIKHRFPANVYNEYPSEVAERLAHEAQALRKLKQQAEEGATVVEMLILHQAAVLNDVREEMSQRRAKLQIKVQAMEAVRGRLETRIDVTNAHHAALLKRLWDGLLPLDESAADYTANLALESASGDSVDVTALLSSSRWLQSGFHTKDPLGGFRGGGLLSVECLAYFVHEYKDKAQNMMARNALSGGNRYPFPVAAINVMRMMLKLAMLDQVPATSSSLILHCETGVDTVLEMQVSERVSRTPFWKIFDDPLAFEKLFSMAFMVLDLHWLRSGATQMGFNPVLDSTRRQMGWLLEQAPRTIDEMWTTWMQVREKTVKRVVTDTIPQESPLLKEQELDAGDRVLAQLDEQDKLRMDNQAKYLEEKMNSLKHSFPEFSMADDTLAKLSAVDIGDVDLAMDSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X0P0</accession>
    <name>A0A6G0X0P0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S1 motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_009661</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000122">
        <property type="protein sequence ID" value="KAF0733415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X0P0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001286"/>
    <dbReference type="OrthoDB" id="1685042at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04452">
        <property type="entry name" value="S1_IF2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000795">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1130:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1130">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.190">
        <property type="entry name" value="Translation initiation factor 2, subunit 1, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044126">
        <property type="entry name" value="S1_IF2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024055">
        <property type="entry name" value="TIF2_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024054">
        <property type="entry name" value="TIF2_asu_middle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011488">
        <property type="entry name" value="TIF_2_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07541">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110993">
        <property type="entry name" value="eIF-2-alpha, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116742">
        <property type="entry name" value="eIF2alpha middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="4">
        <location>
            <begin position="40"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0733415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="339" mass="38301" checksum="663C0071D0CD03BC" modified="2020-08-12" version="1">MSAPPKADEAAQATLDGVETGNELMQLQCRFYENRFPEIDELVMVNVRSIAEMGAYVSLLEYNNIEGMILLSELSRRRIRSINKLVRVGKNEVVMVLRVDKEKGYIDLSKRRVSPEDIIKCEERYNKAKTVHGVLRQVAQDTGAELEELYQKVGWPLYKKFKMEQPLGGDDEKKIEYLHCYDVFKMGITDPSVFDGLNLEPATIASLRTHIGRRLAAQPIKIRADIEVTCFAYEGIEAIREALNAAQLKSTNEVPVKVKLIAPPMYVMTTNTLDKVKGIATLQEAIETVRTVITSKGGALSVKMEPKVVSVNEEREFLQMIEKLESENRQVDGDDDEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X144</accession>
    <name>A0A6G0X144_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CBS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_009543</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000121">
        <property type="protein sequence ID" value="KAF0733610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X144"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019573"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17781">
        <property type="entry name" value="CBS_pair_MUG70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17782">
        <property type="entry name" value="CBS_pair_MUG70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051462">
        <property type="entry name" value="CBS_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48108">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN CBSX2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48108:SF26">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN DDB_G0289609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="601"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="115"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="182"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="283"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="349"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="459"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0733610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="629" mass="68649" checksum="C9C62856242F91E5" modified="2020-08-12" version="1">MLGTNLRREKVEVVFSTKTKVTAAPAPSPKEDTPLTYDLNTSTGSLKSRHDVTEHQPSGESEKTQSYRSSNSTDTDSHEYKLSHSGEVPMRKRGRRSSRKGSDAKPSFSASVRRLRPSKALLQQESVSIADCVKAMVDARTEASLVTDSKGSLTGILTDKDIALRVVARGLDPILTRVGDVMTPNPSCVSPRASAIEALEQMVSGQFRHLPVAENGNVVGILDIAKCLYDAISKIEQAYMASSSQFAETFQKLEANMGETETSLFEKMRETLFLPTLSSMIDGTREVPEIADTATAQEASLLMLQTNSSAVMVFGTSGIMEGILTTKDLMRRVLAVGHDPSTCLVRDVMTSNPECVYLSTTILDALHTMHDGKFLHLPVLNDEGVVVGLADVLQVTCGVVNQIGSFQQQHTANVSPVWNQFWSSMFNPPEAPKPSINYSQPDSHRMDTEHAVAVPSTAPITSTPSEITPSVAPVEPLSRKPASPATFAYKLTDHVQNIHRFTASAMNLGELLQEVRNRTGQDDEELNLYYVDDEGDTVLLYADKDLEDAVALAISHEAAYLRLKTQPAARIDSTDEDLSELLDRLPNHERKVRYHSMSESMIATIAHSGIYAAAGFMVAGAAMLYAKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X164</accession>
    <name>A0A6G0X164_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_009561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000121">
        <property type="protein sequence ID" value="KAF0733630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X164"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0733630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="282" mass="29522" checksum="3397CFDEE18EF56D" modified="2020-08-12" version="1">MATRPPGTVATGEPFPTDAIISPATSLLEDPEVNVKAPDAPPVDELLFTRIAPELPAVDKPLEIAIGPPFTPFPLFRVNDPPVPVEAAPTDTRIFPPAPPVPAPLARVKEPDDAPSTVLKLMLPLSPDEAPTPDCKLMPPPFVDVPAPPVIVTSPPEIPLPPKMELLPPVATELEPAVKLIAPPLPEAPEPTIAIILPPVPPDDAPDSNETAPEFPPVAVFELIVIAPEFPADEAPLVKSIAPPITDEPAVNEILPPAPKEPVPTAALIPPLRPPVAGPDTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X286</accession>
    <name>A0A6G0X286_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_009149</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000118">
        <property type="protein sequence ID" value="KAF0733972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X286"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005078"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33946">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33946:SF4">
        <property type="entry name" value="COAGULATION FACTOR XI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026241229" description="Secreted protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="384"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0733972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="418" mass="44661" checksum="F5112DE2DBF1435A" modified="2020-08-12" version="1">MRIGATFVVTFAAGLGFVSAQTSWNMTAIRTIQARVQSVSPVWDATNNAWVAEFKTGTNTFTEKYVASMDTVNTASVEGALMYVQSEGIDQAIVPGCARKSNMSYVWFYDITIVQPTYAVAEYTSNTAIYPEYCPFVAMDNGMCTPVSGTTLPTECLRYFGGNGQPNLGPCVGGENRQDNPKAPYDNNVWFSFPNSCFTKAFGAKTDSCRASLKGGLCPFGATPDGVSCTFSYTLLGYISIDDLVGITNMTSSAGTLYPDRYAFCQDGGIEYNSQTGQSLSFWANPTDRASNAARSQKMIDFYAAQLLDPVKGANMKPFPSLTDLSTQNPPCYANSPICSSAKNGCRRKLLAQLCEVCSSEASDCVKRPPGAPAFPTLKKAPRSISTGNSSNSTVNGAPPPSPLPGCLLAILLLCLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X2F9</accession>
    <name>A0A6G0X2F9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RanBP2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_009194</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000118">
        <property type="protein sequence ID" value="KAF0734021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X2F9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013935"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 6" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="TRNA-binding" evidence="9">
        <location>
            <begin position="32"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0734021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="16385" checksum="569B35B272E5994E" modified="2020-08-12" version="1">MTKEWICEECEQENTEDDVECVACEAPRPAAASRFAGFKIARVVSVEAIPKTKLRAVKVQPNPEGDDSTELTIVTNARVDDGEQRYVVIATVGSTVEIDGEAVEVKKATIGGRKSEGMLCDSPMLGWKGDAAGAAVFLPNTYTIGDEPPATRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X2K0</accession>
    <name>A0A6G0X2K0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_009198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000118">
        <property type="protein sequence ID" value="KAF0734025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X2K0"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0734025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="72" mass="7863" checksum="2D0BC82C0F648F8D" modified="2020-08-12" version="1">MFFSARHCVSLVYAVSSRVLNCGAALKVAQVILSNRFNLDRKLLPHRSSSMNSTEPPMENLCATPIQSPEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X3E0</accession>
    <name>A0A6G0X3E0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_008963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000115">
        <property type="protein sequence ID" value="KAF0734362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X3E0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001557"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00257">
        <property type="entry name" value="beta-trefoil_FSCN-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008999">
        <property type="entry name" value="Actin-crosslinking"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50405">
        <property type="entry name" value="Actin-crosslinking proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026321021" description="Ricin B lectin domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0734362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="182" mass="19828" checksum="F446A1DF9F2EC2D0" modified="2020-08-12" version="1">MVSIQTILLGAFALAQTVSATTCNFREGEVIALKADTGYYATRCRNCVGGTELDSVSFQGPINSGTPYSYWTIVDAGDGKIALKGDLGYYLSRCNNCVYGASYPDQAFVHVSDWKSAPWAQWSCEQADNGKIALKADTGKYLARCNNCIKGGPADVAFVHAAYWKESPWAQFDVEYLNNSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X3G3</accession>
    <name>A0A6G0X3G3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_008848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000114">
        <property type="protein sequence ID" value="KAF0734388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X3G3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005387"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0734388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="137" mass="16334" checksum="4F91ABB56AEFFEC2" modified="2020-08-12" version="1">MQQLHKEIVEQNHAKQDKARERTSQYPACNADRGDYVLWSRVDEAHHPKLLVTWVGPYRVVEVNEFSARIEHLITKEQRDAQMSRLKMYAESSFEVTDETLEHVADQRTLLMVARIKSHKFDKIRDCYYMLVHWEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X4E1</accession>
    <name>A0A6G0X4E1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Roadblock/LAMTOR2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_008726</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GAMAD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000109">
        <property type="protein sequence ID" value="KAF0734654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X4E1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005140"/>
    <dbReference type="OrthoDB" id="9985637at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10779">
        <property type="entry name" value="DYNEIN LIGHT CHAIN ROADBLOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103196">
        <property type="entry name" value="Roadblock/LC7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Roadblock/LAMTOR2" evidence="2">
        <location>
            <begin position="9"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0734654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="125" mass="14358" checksum="158333163F88DAC7" modified="2020-08-12" version="1">MANNAPNEVEETIKALKLKPGFFSYIIMNNDGIVIKYENMEYKMAVMHAYHILSLYARSKKHLSKLFDASECDIECLRLRTKMHEMIIAQYTRFTLVVLQTSEAEVVKVDVKVEEVVKEEATAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X4N8</accession>
    <name>A0A6G0X4N8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_008547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000103">
        <property type="protein sequence ID" value="KAF0734885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X4N8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020341"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0734885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="238" mass="27207" checksum="4BCF222BE6C8DF0A" modified="2020-08-12" version="1">MSKRKGMSSKGRGSGFLSSEVGALLDELEDSLPLCTVEWEAVLRLHSQRYPVFQLVSPTSANRDPMIPPDVKRAKLIRIEMPKRADIGTATEEGNLLSSNESASENDAESDYEAQDGTQAQMDSTAGAYNDLERIGHRESLSTSSVLTPRPLVSKRQKTSEVATSSSTLRVLEMQLILEDKRREADREWREEERRVREAERKEKQEELRRREEERREDRKELYSLLAFMFGIRKNSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X7D3</accession>
    <name>A0A6G0X7D3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_007761</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000093">
        <property type="protein sequence ID" value="KAF0735755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X7D3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014482"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051242">
        <property type="entry name" value="WD-EF-hand_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44324">
        <property type="entry name" value="WD40 REPEAT DOMAIN 95"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44324:SF4">
        <property type="entry name" value="WD40 REPEAT DOMAIN 95"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="58"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="280"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="322"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="364"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="451"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="635"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1066"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1071"/>
            <end position="1088"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0735755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1116" mass="124852" checksum="50CDC35E2AB303C7" modified="2020-08-12" version="1">MANNVPTLSVAARAANLSESMFKLSELMKLHDVFEQRGALTEKQFVTHFHSILESDSWTPSQISQLFMKIDANSDGSVDWDEFTNFMFVHSQSASEAAAQLARVAFVPLDDYDETATPSGSQRPRDVIVAFFGLSKGNHFVGCTAHGLVTLRSSTFQLQTSFQALISVDRTNAVTSVVHLSASNKLAITSVSTGVVLIDLVLAEKSSQTHLPSTVLAHAAPLCLCSTIDDDTKQDVLYIGDDVGCITKIRFHDHGPWHFCSGDQSCHNKATVVGATITRATRHQNHITKLVFVPELNSLVSASRDGTIQIIDVHREVVKREFDLHRGAVYDVAWCREPKFFASCGVERDVLLWNPFSETLLGRLQGHTCSIRSVVWNSEGLNLISLGLVDGVIRVWDVRQMKCLQVIHDASHEKSHTKLIYFDEMSKNLLTFSTTMNLWPMRQAAGIAETRQPHDETITHLLFNPSFDQLVSIGTDGHIVLWNALDGSVISHFFMAHTTITAAALDDTGRRLITGSNDGTKVTLWNFSNGSRLATLLKRRPTPVDDVRGKFQNGLGQRGILFPRMNTQPVQARKSISKANEVTAVAVVTSAMPQSNGRGFVQSKYILSVGWDRRVYVWLDNADQDYLLRMPEDLSIGHSDDILSMAFCPPKLVATGGMDGYVMLWGLNSGDLMAKFSCRSSVESLFYPRKLGLLIATTSSASIMFFNARFSLHHATFELGHVVDSEIRVIKSDTDGTLIVAALACGSVCVFGIGDPQLVPMQLHQFHRWKAHDGDIHSMEFIEVTHLLDSFVVTASQTNMKLWTLGGTLVGQYGRDKWLLHDRFVRSLRVPFEPDRVDIQATEGEGHPQSIEMYSKEVARIASRGPPVINDVWSRHDIHGTVIDVLTLTSTSRSKGAIEGLNNQGQLVDLELHLLYDIQDDYATWRREDFLTTLVGHVLQEYPWSVPFKVLRLQFDSAGWHLVDTSGQVHALPAEAECREMKFRPYRSLALHIMNPQRLPPFPSASCDENPHELIKSMGSQTSQDQFFVASKYKDGMHQRKTRPPTLRVARNSPTKLSLECHTLRLPQMPKEPRREEQPLSPRHAIDERKIYTLQEAKCPPSPRKQWDYYLPLVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X811</accession>
    <name>A0A6G0X811_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_007238</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X811"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017256"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005942">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016303">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035005">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 3-kinase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00864">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002420">
        <property type="entry name" value="PI3K-type_C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000341">
        <property type="entry name" value="PI3K_Ras-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF14">
        <property type="entry name" value="LD28067P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00794">
        <property type="entry name" value="PI3K_rbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51547">
        <property type="entry name" value="C2_PI3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51546">
        <property type="entry name" value="PI3K_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="88"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K-RBD" evidence="9">
        <location>
            <begin position="190"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="C2 PI3K-type" evidence="10">
        <location>
            <begin position="334"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="535"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="PIK helical" evidence="8">
        <location>
            <begin position="630"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="7">
        <location>
            <begin position="884"/>
            <end position="1143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0736215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1143" mass="129419" checksum="4E9143237286835C" modified="2020-08-12" version="1">METPSIYVNDIMPSNETLAWEQTAQSIRNEILDQATTTFMPLTARSCVPEYETELEVPSESYSTIKSLVRLPSSLLVDISPSDLETKSPSHEGFLMVGSKQGKMKDKYCKLQNKVLFIFNQQPRSNQDLQTPEVCVALDDVLLVRPFDDNTLQLNIELILAESRYLLKAMEESQNVEWVDALCHAIRYDSVSITYRRMLQLGIGDLLPPNAKWVFLLPSCTVQENVEHCFECFCSSPGSPLLHPYDPGDYVLKVNGLTEYMTEPDKLLSSYSHARECLVTKQTLYLTLVPKSDIELTFCREPEQKIQTAPSSSTLEPSDVKERMEEHFIPSSQCTSPLRVSLHQVGKIPKQYLDDVSRTPLRFQNCIVVAELVYAGRVVESIGKSEFAPLSADGDSHVVAVWKTPIALETRLPVRYFPQEARIVLTVYIAKQDGMTTRHTRILSTAWNVFDIDGWLASGNHIIECSNSAQEWTYGPLAKTSTLANEARFPYVEITLSVPVAETDLPSGRILFDWNVTEAPPQMEIPKNYSQRSSDLGRAGWLSLKKIMSIQERRLWVVLDPQSRSLTLKDSPTSPAIDVIQLENARIEVSHDAEKRFTIHTMINPAELSMSTETPEERHDWIQALTIVAKTDLVSWTNVPLGSLREAILANPLRPFTPLENEILWRNRAAFMDCFEALPRVLNSVNWFDPHEVNEIANILHKWAPAKQPANYLALLSKEIVHPAVRGFATDKLSTLSAASFSLYLPQMVQALKYEVYHTSPLAKLLFRRALEYPHQIGFDFFWRVHVETYNGRYRERFGVLLNSFLDSCPAHVREMLEIQHKLFSQDGELDRLCRQLKSLGNGGMKVEELTKTLRERLATINTDLLRIQIPLPINAQLAVSDFVVGKCRLTPELNLWLEFKTFNDNDLQNPIVAIFKSRVDGRSESFALQLIRWMEGVWRMEDLDLPVDPVRCIPIGPLTSMVQVKEYAVTIDSIRSNGQSFFRNLIGSGKAEMKTTKKLYCQSTAGCCVAAYILGLGNQREDNMTISIQGRLRLTEFEQIIHQTKAQEKTNSRGKSQVKPFVLTEAMVKVFESTSTTQKFLELVGQAASAVRGNLHLLVSLCLLMVPADMPQLKDARSIDHIVAAFSPSLLQDWRTNLLSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X8Y0</accession>
    <name>A0A6G0X8Y0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PI3K/PI4K catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_007454</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X8Y0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000926"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005942">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016303">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035005">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF14">
        <property type="entry name" value="LD28067P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="424"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="PIK helical" evidence="5">
        <location>
            <begin position="559"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="4">
        <location>
            <begin position="806"/>
            <end position="1080"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0736437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1096" mass="124567" checksum="10C790408D634A8A" modified="2020-08-12" version="1">MWHYGAIVEQIAALHRDCTFPEMDQSEYTSEAKPLQVFTSVHVHLQALAPKTNNPIVWLSYVLLDVQTQRKHKFKLKRRYLEIRGKVLWVGKHPMMMQMWVHIDNLTAVEPSCLEPNSLLLVTPNMYILIALEDEVECARWRGLLRHGRPLGYNTKLLLKTHDHDIAPCIESMLQLDWSIAKCMDHLGLDPDEYAIHVNGTNLFWSNPSATLDEYAIPGNELQLTAIPRISPQSTASITESTNSLNVRLNQVCHIFEEILELRDGQRIVADRVQTSCLVRMELAEGSRVHCSVDSDPFLLRPSSSQQLEDVWYTLWNIPDVLTDSWRLVCTIFALDGQQPQDDDPVDESQWIKLGTTGTTLLTVNGNLLPGSLYLEILDSTADPYRGPLPLGVTHGSPYIHLECLWKDLYSSRRTSQLLHNSPTILKQGTLYEWTSIGLWSKWTARWCAVTSQGQLIMDKSHPISLENARLAIADKYTSTSRRASASGSKSTQKEYTTYAFTIEVDKQTSLILGSLTRHAREDWLHTLRMAIPTTSARMSTRKSVEMTWSFRGTTLSDDVELMEDPSVTLQWLLARMEVDPLFSLSSFQRTILWQYRHTLPKHFSILPRLLTCREWTNSTHADELKVILAGWQRPKHATEYLILLGSSLSHLSTVRSFAIDRLESLDDTTLAKVLPQLVQCIKWEPFATSRLLTWLIQRAVENLRDLGVPLFWALHVETFVPHCTQRFEIAKQAYLAASGRPMRRMLRSQLELCQELNRLTRDMQSIASSSSLDVLLRQRIAALNVQFAGRMSLPVHGRCKMVQFVTGECRVLKSPKRPIWLTIETTSHKKVSVIFKAGDDVRQDMLSLQLFGLMEQLWTSAKLPIQMQTYGCVATSPTSGVVEVVADAVTTAAIHKEGGVLGPLQEERFTRWLRTQNPAADDFSRALETFRQSCAGACVATHVLGIGDRHNDNIMMTQRGLYFHIDFGHFLGHCKYHMNFKRDKTPFVFTKEMAFTLGGVGSVVYTSFVELCGQAYNELRQHLHLLTTLLVLMLPANMAELRDMHDIYHVVDALALDLTPTQASQDFAAKIEACLGHPYKRIDNTIHNLVHLLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X9E0</accession>
    <name>A0A6G0X9E0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_007128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000088">
        <property type="protein sequence ID" value="KAF0736680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X9E0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016930"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0736680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="466" mass="51873" checksum="22352A5CD32A5262" modified="2020-08-12" version="1">MQATHDRAAIVHDVLCNAALQRERFVRVYECLLASRAKLDIADAVIVHQGELRRWYYTSKHGEVREKPSHELSLLEIKKVFVKKTLQRASNVARKLGVLFHESGKATILTDVQFNTIVCNANAPAWSKTYVVQPFICGKFGPNPATYSAVFGGHHGRIQCYKPPSFLLHTIATGVDGMQWSVCHPPWHESTKETHSSYDEILQRHVHTIVHSVEAYTRFKVSHLSADFILTAEDRLVLVRVANVVFEADQKDLPASMRSTRRRPATAHPTTRPVDPSRRIKSCRGHFCVLSTRRTPPAFDIALTEPSSTRISNKSIIVAETENAFLAGKGHFGSNAKLATNLCHAVASSRALADLSNVDGVIAARNKLLHELQWFKQQAQTVAEASKQVARFYDTTRVCSLCYLMYQRLDAARTAFTADSTQSTARSTLKSRLPPTKVAFGAIAPPRKQPTKGIHAVRSTTSLHPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X9Q8</accession>
    <name>A0A6G0X9Q8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfurtransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_006930</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000087">
        <property type="protein sequence ID" value="KAF0736770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X9Q8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003633"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01448">
        <property type="entry name" value="TST_Repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01449">
        <property type="entry name" value="TST_Repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001307">
        <property type="entry name" value="Thiosulphate_STrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045078">
        <property type="entry name" value="TST/MPST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364:SF27">
        <property type="entry name" value="SULFURTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364">
        <property type="entry name" value="THIOSULFATE SULFERTANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00683">
        <property type="entry name" value="RHODANESE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="5">
        <location>
            <begin position="42"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="5">
        <location>
            <begin position="189"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0736770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="312" mass="34170" checksum="4437C6F66690485D" modified="2020-08-12" version="1">MLRAGRVQPLLKKSGLSFSVRAMSTQLGPLVTGSEIHALESSGRAVHFVDASWYLDKTRNGRAEFEQERLPGAVFFDIEAIKDKHSQLPHMLPPADEFSAAVKSLGISNNSTVVVYGGFNCFSPARCWWTFKYFGHEHVHVLNGGITRWKSEGREVETGPPRDPTPSASYTATAHPNLVLNAQQVLGLLNTKDQIIDARGPSRFYGKDPEPRPGMRGGHMPSALNVPFTKVLSSDDFSIWRDADEIRQNFEASGVRLADKTLVATTCGSGVTACVLTLGLHSLKVPLERAPVYDGSWSEWGANPDLPVVKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X9U2</accession>
    <name>A0A6G0X9U2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bms1-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_007031</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. TSR1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000087">
        <property type="protein sequence ID" value="KAF0736876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X9U2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017814"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012948">
        <property type="entry name" value="AARP2CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030387">
        <property type="entry name" value="G_Bms1/Tsr1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF1">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08142">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22298">
        <property type="entry name" value="Tsr1_G-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00785">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51714">
        <property type="entry name" value="G_BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Bms1-type G" evidence="6">
        <location>
            <begin position="85"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="367"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="369"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="409"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0736876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="748" mass="83451" checksum="312CC1C5F819312F" modified="2020-08-12" version="1">MSSDGHRHRAGPLKQKNKKHKAGRHDTKTFLTKKSGGKIERAPIKSSKITVAGTKQQRLQKAKQWKQMKREEVWQRNRHGGLSGAPKIVALVPLGPSADLDAVRNVILESATNVEYSEDAHMLGRHTSAFFAQHKQKLSILESGHELLGILDLAKVADVIVFVLPMFNGPDAAVSADGDAILSAIRAQGLCATVGVIQGLEVHPPKLETDCRKYGTRFFTTEFGDAIKIAQGNNNIQVVRAVMTAQPKVLHWREIRSYMHATSVRFNPESEMAGTLQVTGYVRGRPLSVNQLVHVTDIGTFQMSHILQGDQIVATADPSKREDLQFEADVDTFAADQTWPTEEELKEAASKRTEADVIGMSSYQAAWNVDDDDFDGDQDMEKDEEDDDEEDLPDQTFCKVGADAKTDAGDDDDDMSLGDDDQDEATRAKERAALQAEHQAFPDEVDVPADSLGKDRFARYRGMKSFRTSPWDPKESLPMDYARLFQFDSFTATQKHILDESKAVADEVDTLNTPIHNGEFIVPGTLVTLVLINVPVAVVQERMTVNRPLVLSSLLRHENRASVLNFSIQRHAPSAEIPVKSKDQMWFHCGFRRFQGCPIFSDQNLKADKHKFQRFLPTGGWSVASVYGPATYQPASVLLVHNNALIASGTLLNVDPDRIVLKRVVITGTPVRVKRRKAVVRYMFHSPEDVRWFKPVELTTKHGMTGHIKESLGTHGDFKAIFNKPIKNHDTVCLNLYKRVYPKRVVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XAU5</accession>
    <name>A0A6G0XAU5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_006452</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 81 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XAU5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015808"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052861">
        <property type="term" value="F:endo-1,3(4)-beta-glucanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005200">
        <property type="entry name" value="Endo-beta-glucanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040720">
        <property type="entry name" value="GH81_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040451">
        <property type="entry name" value="GH81_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31983">
        <property type="entry name" value="ENDO-1,3(4)-BETA-GLUCANASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31983:SF0">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-D-GLUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17652">
        <property type="entry name" value="Glyco_hydro81C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03639">
        <property type="entry name" value="Glyco_hydro_81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52008">
        <property type="entry name" value="GH81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 81 N-terminal" evidence="9">
        <location>
            <begin position="123"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 81 C-terminal" evidence="10">
        <location>
            <begin position="443"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0737279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="790" mass="87520" checksum="09DCCB6E713BBAEE" modified="2020-08-12" version="1">MTKVDLRQQSLPLYHPQQQSLQETSGHGTFVTLAVPKRPSTSSSSSRFPMVVSIALRSAMAMACLALGSLVLPLPHIFNPTTPAIQDAAACSSDVMSSPLCLFQASKAQSWFAPPRNLHASIPADKPIPTNRWWGNLISAARDDTVPEKRVWTNPYAIVLLTQGIAISFPFDTRYFQGKSGNTNGAKSYSHAYTKDITLGGGNSKAPFLVTGWDDLGVTARQDQGDNKWIETTLVSGMAFTTASYSNVAPRVTTTHNIMSINHVQRTAGRTTKGETIRGVKFLVGLDNGQTWVVYASRPVTFKVDGRTLESPDTFTGDIRVALVRKPDDITSLDNYRGCVVRGGNLTHDRFHYRFDWATSGDCAPGLLHFGLPHHADTLDATTAAPLAGMTQLGSATRGFMIPIATMSKALRWKFTENLVPVELYPRQRPTPERLKTTRLLDHLAADIDATWNMPNDGSYYFNGKKAQKYASLCLMASDRAVVGTDLTLLKRCQPKLAAVLAPFIKNSFAHRLVYDTVYKGIVTSQGFDDADTYADFGNTIYNDHHYHFGYWVAAAAIANVVHPQMPGLATLNQRITFLIRDVANADAHDPSFPAFRMFDWFKGHSYSHGVTAASDGKDLESTSEDVNFYYAMALFGEATGDVPLAHLGRLMLSVNVHSVQTYFLMDSANKVHPPSIVVNHVPGIYFDNKVSYTTWFSDARQSIHMIQMLPVTPVTEFVRTKRFVQEEWTDILTHLPIVKNDNWNDPALSLLYLNYAAVDPDLAMKKLQYMALDDGLSRSWALYMAASRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XBK0</accession>
    <name>A0A6G0XBK0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ae201684_006651</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLT11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XBK0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011415"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000006">
        <property type="entry name" value="Putative pre-mrna-splicing factor rbm22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048995">
        <property type="entry name" value="STL11/RBM22-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032297">
        <property type="entry name" value="Torus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF6">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21369">
        <property type="entry name" value="STL11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16131">
        <property type="entry name" value="Torus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="13">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="11">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="190"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="190"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF0737491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="267" mass="30177" checksum="74FE1B4CBAB0809C" modified="2020-08-12" version="1">MTERGMGIKTDTFKHAWEGGDKDSFPQLCEACLGEDPYVRMIKEVHGKACKICDRPFTVFRWKPGKKARYKKTEICQTCAKLKNVCQTCVLDLQYHLPVQVRDAFLAVSERQDVPESEANREWFAQQHNAMLEDQGVVSAYGKSAAPSQALLRMARLDPYYKRNRPHLCSFFARGECKRGETCPYLHEMPKDKADPLSKQDIKDRFHGRNDPVADKLLAKHGGGSELKINRRRRGIPPPPPPPITEQKNQSVVPAHIPPPPPGPPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XD16</accession>
    <name>A0A6G0XD16_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">BEACH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_006046</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0738055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012892"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1540.10:FF:000001">
        <property type="entry name" value="neurobeachin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051944">
        <property type="entry name" value="BEACH_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108">
        <property type="entry name" value="BLUE CHEESE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108:SF4">
        <property type="entry name" value="BLUE CHEESE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="6">
        <location>
            <begin position="2401"/>
            <end position="2524"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="5">
        <location>
            <begin position="2542"/>
            <end position="2836"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="3000"/>
            <end position="3041"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2338"/>
            <end position="2358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="2344"/>
            <end position="2355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0738055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3199" mass="362439" checksum="8EBFA7E1ACA39448" modified="2020-08-12" version="1">MKKQLTKLFSRKKTVDESNTAKEILPVKASPPTPNVVPPFDARYARITSHMKDINAVCKNFTWNMKKVQNDAGCHVDKLVSSINAIGLKIQSAMGDTSVHWGQIYCSGEFGITLCEQTTLPALLVETLDLLRLHFVIEHAKRLGSTSEDLKADQNFERCVYELGYALAGIVANAAVMERYRCEIVNLLRMAADLYAPNSVIIREIVAMTITATINSTLNAGIVWYLHDAQAIASVVKTIYFMMNAPFVTTQNASIAAGTFHTESIGGNEEIEVHLAVSKALGLHKEVNSIEPVDEVRPAETTYSFSSHDPNIGATVLLNFLQASCHYSFILVQDFAQVGGYDVIWSLVRQDAPSGMEIFIGLLPLGEGVDKLMDWTLKKCGAWNDSAFIALRDYLLKHIENEPCDGEDSLIPYFNILAQVYTRDVENFKRLEPKTHILTSVVTRLPQLRSSSRNMVLACVEHIGVEVPKIEFTRDILNKICVHLTETKEKDYEFARLLCETLTKMLQLVTTSDHPLRDILLEFGLLDKGILPYFESFTHEKDVRVQIQCLSNLTRELLHNHVASCTQFRQLHVHSTLYRVVKERVEDVETFSLLFQVFIELAAVTKSTQLLQGIESDVQTLLSFVHHCRQMHESLKVTLKLILQYLNNNMAVQRIWRENSGLENLLSVMSSLNNYDIHAPHVKLIFDIFKLLLENIETQVYAKEHHVYHTIAECLVATGWMATSHYTFLLQNIFLLIFQPIEAKKVNVRNPDAAEMLFDIWPNLDGDQRTYLLDELLASLNQLTKPHEQKAALISAGIFRWIYPHMEESPRLEQLLYSLSTNEIPMPNLRDYFRVLNKTSDHGLNFLDTVSKAQGVPHSNLQHHSYIQVMSEALWPPASGYSFSCWFNFPPDIAEANHTVSVPMNEGYLHLDHGLGAKYVVLVGSTLSIYVSKEDAMQGAKEIGTLEIQEYMEEGIDGFRVCCNDDWFSIRVVDVGHAPAWKKALHEFAKPYVMLMSLYAVDHPQCFTRVYFDPGTTCLRIEISQKHIVFKDVKVGLFAENTWHHLLFTHRKSVMGSSLVTLYIDGGEVGSKKLAFPASTAPSPIRCFLGSDPHLFPSTCIRSVSLGPSWLISDVLPTQAAKCLFMLGPSYMNSFPGNVTSLGAIGEWTESVITSFLHWIIHRKVEIAQAAARLQLHSLKLATKREWQEEMVVSMVDEEDKEIWPIIWFRYFLDRYCSLKLLGEEWLSQITSFTCPEEVVMWSLHTKVPNTQAHMQFVETEPSIPLDLPRMLPTLGSLGAVLLPLADTLETSKQLHCFLRILNRSLKSNPVTMAWFLEQNGFRWITGFLLDRVGMIDVNILTALVKLAISGTLKVEKYSLSECKVAACVVVSIHAVSQILFQISLLSQLSFELQHNLVMLLSLTIQSNNPNAVFNARQFRQAQFMQWWLAYTAQLCRSNNDINALLINELLLMLKMFLAVEPHVDDFILFSDMFLSALNDVKSTLRHKLLHFLLQQVEEFPILSRTLVESIFYRIHRDRKRVHIANPQWCTKPVTFSPDGLEHTLLEIICRSTSSDLIPFDALAATRLILSLAQLQPAFAMHFLVNTQLHIRMKQVLSIHSSHVSTFIPLLAFVGSIPINHITVENENISKAFPSRYTPIAIDRDCIDSVWIVLGHLLRQNQNNNSNDTTTLQILEWLNSQLKRDSLFFQAVCRSSSAFLGVIISCIEPKSPEQSSNSIAEVAEQCLRTFLMLSFLERDDWADNMMFCLQLWRSDQRQWLVLVKAIVEKTEILGDKGSIAGMKNLCSLFLSLLRLIISRRKRDDRLKRTDTNPKLLTFIWNVELNEAVVDFLCQAIKNCGEKSVLSALGDEAQQYFYCVLVFCAQGFILQSLYPIRGVTYWHLEVLERVVQSKNLLLQQTNITSVILYSGSSTGGSDNFAQATGFRMHMRQLSIHGNQKEFVLGQESDKFFVLCLATSLFRILLENQTCFSTTTLWKFLLQQRMGLVKELLIVEPKASLLNSMSNSKKESIDVLHNGFDQVLSIDSVNHVQYPIFFEWIQSHATLLHNVLSTRTDPIYQSLVETIEGSTALRHPKQTDWTVRVGFELPGGQSSFEWTAVDAKIEPILQHASEIASQKFEEFMSDQREGVKEAKLNWTRIRQSSKHSRTLWADPIKMRVNASQTAYQSAWEMTTLDPTEGPGRKRTRLKWSETQQVQQVDRITVEKRSSMRISKIQNCLEFHEMVEVYRQCMFKQELNLDQCKFPQTRDRLQNLPLSPKTIADVIHHDFMENDKYLKLGISSVVAQEVCKALALAKEESVNSSNTEFVVLLPSTLFDVADSEAMQKALIKPSAIKVVEEGNEGHESDEEFSDEEEDLNNRISIDGRLSETILEEKGAVPEENENNLHTSDHTYGGILRFLHRNDQPPQRATNAMLISGMRKANGLFLMGAESIYFIEGFILTDDSQTAKSLIDLRDNPNASIKPQPNNSKSRLQWRLKYYDIKQFYRIKFQLRPVGLEIVDTSGWTHFCTFESSRGREDVFKTLFQMPIHNSIYWAHVLRPGPLQSVKRLRQSLTKKWLRGALSNFDYLIELNALAGRTFNDVTQYPVFPWVLADYTSQTLDLSTDSTYRDLSKPMGALGEKRASQFQERYQAMASDGFDGSPAFHYGTHYSCSGYVTYYLLRLEPFSSMAKELQGGEFDKADRLFRSIGASWASASAENLQDVRELIPEFFFLPEFLINANRFDLGITQNGEVVNDVILPPWAQGDPREFIRLHRRALESKFVSENLHLWIDLIFGYKQRGQEAIDALNMFMHMTYEGTVDIDSITDPLLREATLAQIENFGQTPSKLFNSPHPQRKVPQLHSQTLSTLLTHAQDLSLNAQSSIEAYAKWHTPLAPPLVSIGKDYVFLKKFHSSHVMEEAIGDVKFVSDRYVCKGKSCALIPPRLKKYVDWGLGNGSIALRVLKSKSLMVIENLHTSEIRCGAFSEDGLIFVSGGDDTVVNILEYTKIRGERQFTHKGKLTGHDDAVTCICINKSFNLIVSGSKDQTAIVWDLRTRSYLRELKGHDAPLRHVGINGANGNLLTIAGAQVRIWSINGDLLAAALLPSVGLSSVTSALCTNCDTWQNGVAVVTGHTNGTIACWGIQYPSDIPPSVERDAVMISSKDKTIPSCRLIIMKLLLEHRVAVTALTLSSDQRQLISGDQDGWCIRWVDDSLTNSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XD73</accession>
    <name>A0A6G0XD73_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_006114</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0738131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XD73"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018078"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
        <property type="entry name" value="FYVE_like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="START" evidence="7">
        <location>
            <begin position="146"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="345"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="407"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="551"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="694"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="884"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="438"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="459"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="488"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="514"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="571"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="698"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="713"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="892"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="908"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="933"/>
            <end position="956"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0738131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1013" mass="110139" checksum="99723793AF1A6E62" modified="2020-08-12" version="1">MAASSGEMLHLTDEDVNRMKSLGREVCTHVAYSARRTETGRSGVRWNAIGFENQVELFVGEDAHPETDRTLSYMCGVTQVASTINEVADLFNSTSDAHDEFYAHFHQDLAGIDMLASIRGRTRQYPRHMISLKTVTMLSPSATANSRDFVFLESQEDVMDAKRNKRGWVCAMHSIDLPNVPPRQDVVRGSLYRSGFVFTESETPGMLEAIYLLQIDFKGPVPIHVRQAMMKQRIMCLQVLADHFGSDAQSPAPQQAPTSAAPRLGYADDARFSRAHDNSPHQQAGGGNRYGQDSRPVYQSAFSMSDLQNTTPGALVQQSAAPGRSLSGSAASGLQLLGDIHLKPKQNATQCACCVSSFSFLKKKHNCRVCGEVVCSSCCTQQKPTHPIEGIKKFHICTLCTMDNRRSTSRTASSHGGGSKSRGDGRSVLSAGGHKSPKSSLSGTASRFNKQPSGPAAQPAQSRSRVDQNSFEDRHDPELRQFGYGNSKPVQPQAAQTHPAQRNVVMAPPPLPNASMSAPNNFQQSPNGYNGHPAPKQSAHHGYHLEAQAAPRVQPRYNRSTYQDPHHDHLPNNSSYQQSMVSTTSYQIPRYNGTNRPDDPRVSLRDERDSFLNMYDEVGTSVSRAQPVQQTPQYRQSSNHRHLAQPQEVYIPPDAPTTTAVNLGDLKNAPDVLAALNNARSAGGSSGLRLEIIPSGPPQQQVPQQPYPARGRNPHETIGEHDSYSYDDPTPPAATAFLPAPPLPPVPAQQQFAEPNAHEAMRYLPPSISNPQAPPAVESSQMVAQGNAPLGTYVGSRYRIKETRYYAPSPDASPDDYLTQERDSILVDMPSQPQLPAGGANVVANAVTTTAVTTTTPATGNTSPTALTVSKFLDQDIDMFLQPMDKNKKPKQPTPPPPHPLPLDNTPFQQENGNGGNQVSMDDLLMRLHAHQEPPPPTRSPSPPPVAPRPTSPPAPVHQQQPVPAPQPPHSEVGEAADVAMLTRLLVERLQVASDSEREAIRGALTAVQGQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XD82</accession>
    <name>A0A6G0XD82_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_006083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0738094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XD82"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004073"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="508"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0738094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="567" mass="63058" checksum="D115A8C7443ED094" modified="2020-08-12" version="1">MSVKSPLMYVDDSIKPSLGSPIPLLEKQPKKESRTIANLKNSLRSIGNKAVTLFDESPGYHSRDNSSRSTQSASSRSSSNVSQGVSPKVPTSSLAIVINTRRLQENNDDSDTENELASSDPNRVVFVRDFMPDPRKLLQGRGSSAFVRSLIRANVIDCASCKWSPAYFSYVSYGARRKQLTTLEANSLRWLICQYIIIEAARRNAVQQALREQLGRKLTDFRIAVQCVSGMTVLKYGRKGKPHTTQLQVEHADSIRWTPKLGHHLTSMLQQQKQKSIALSTVIAIESGIKSEVFRKAVKDSKSQLDPTCCLSLITPTRTLDVVTSSRQQCDWLRRGVELMVAQAHENEKKASAHVETTIMKKLGSMTVFKHGRRGKPHKTQLNVDKYGEITWKGKSGGAVLLPEVIEIRLGHGTAVFQRLPQKSNPKHCVSLVTVSRTLDLELVSESERDYVVIAFRYLLNKMRDRAREAKRMKAERGVRKLQEAYEYHARNMQLQNQTFDLERYPGAAPVASPSSSLSSSAPSSPVALERYPSQPRDSPDRLPSSSTSSTGSSQASSPATSSTMPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XDR1</accession>
    <name>A0A6G0XDR1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_006164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0738188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XDR1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011749"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="75"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0738188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="322" mass="36447" checksum="90CD678A0A4F51AE" modified="2020-08-12" version="1">MASRPAWLQATNVLATTLRDYIALQKKHQDELRLFADKACKVLEETAASGSNQSELLNQVSALFAHAASAPDEMCVNLPIDIQELQEELNRQEEAMDLMRRETEKCREMYDSSKNTYVTSLTTFHDSFEKASRSLSTALDKGIDPAIFKVVDSDNTNQPVSTIKPSKDSKLVGHVMDAISRAKRHKDQCLKEYKDFRKVAGEYATSLDSMSATHQAVERDSIVYITSIVKKFIVSYFSVVKNIEYDLNQVHASVEEEQAKIQVPARRVGHAATIHQEMQMHPPPLGETLELSYFLEQYFPTTHVRPLLVRHQPRAQLHLVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XFB6</accession>
    <name>A0A6G0XFB6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_005303</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000068">
        <property type="protein sequence ID" value="KAF0738932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XFB6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006941"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0738932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="136" mass="14896" checksum="3B2E2E119045D005" modified="2020-08-12" version="1">MGHIAYADDGLLESAGSSSQDDVDGDSEDQTVPSNGKHSHKRIIQDEIERQRKMRKPNTNKRNDISSGLVALGESLSKGIVEAANLKSSRPSSDNLENAISKTNKQLEEMSSLLKQHIDQSSAVHTALLKLLQEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XFL8</accession>
    <name>A0A6G0XFL8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_005490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000070">
        <property type="protein sequence ID" value="KAF0738881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XFL8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003236"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47691:SF3">
        <property type="entry name" value="HTH-TYPE TRANSCRIPTIONAL REGULATOR RV0890C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47691">
        <property type="entry name" value="REGULATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHAT" evidence="2">
        <location>
            <begin position="27"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="NACHT" evidence="1">
        <location>
            <begin position="268"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0738881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="829" mass="91321" checksum="04D2F46F10B33CAF" modified="2020-08-12" version="1">MFVHLHSSPLVVRQTASSASKGLNAPRAFGISTDVQPIEILDVKEERRLLLQCLQECGKQVKWRSEVADVHTFRKVVSHGCRALHFSGHGVPGKVIFESATCEAHFLSQQELKTLLLAGDQTSPENAMRLVFVSACHSESVAEAFVSAGVPHVVVVPKEDKVLDQKAMEFSKAFYTALLAGHSVLKSFEIGQVQADIVTVADAHHSKFKLLGNGDHATSFLFSDVPLGRYDDLTPPLPTNECDAVAEVFIGRSLEVHAVYTALAEGARMICITGEPGMGKTEIALQSCQYATDRYLFQHIFFLRILPHETHLTRYLLSRLAKCFGITSTTDDLDGLCERIREKLDAVKAEKRLSFLLVLDGCNHLFSKHNERNELPLFQSILSQLLRRVRSLSLLLTSTSRIGGGAGLDVGVGERIIHVERLPAWDAALLFTVRAPRRLQVHEMGGGLEPFSRSKIMEAVGGHPKTICAVAQLLERRDLDRDMHEFLQYLIPAVIAGLDPTSKKHFANDYCPLLPYKMAAKQSSMEITKSNSSLDLHIPQQLGKVNLGSSASALSNAYNSQTIGLIDHETKRIIPPPSQPPSLVSSMSLATGIGQTNSTSTSVSSGGSGGSTGMSTEQLQLFAIKRRVESVFSSADGGMIWAHAVVEFDKTTKSPHERSQTFDPREIRQVASIAAVPFEYVAQQISRYFATKVRQAAVKRPLSTRCMAFLRSSNRIWGPQGNSPETYNGRVDLEMFAAFWAWFEPLLGVIKVSQLWEFKHPRLLHGFISKDACLNMLSACVAGTFVLRFSETKQSCVVVAYVTAVGHSSKSISKTAATWWRFQLSRGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJL1</accession>
    <name>A0A6G0XJL1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Charged multivesicular body protein 1b</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_004053</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000051">
        <property type="protein sequence ID" value="KAF0740507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJL1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003427"/>
    <dbReference type="OrthoDB" id="10266568at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0740507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="22530" checksum="212E9A71EC847F6C" modified="2020-08-12" version="1">MFDFLKRPTLEDELFKMRFTAKSLVRNAKKCEKNQVAQKAKLKQAIEKGNMEGAKIYAQNVIREKNQALSYLQLSSRIDAVAARVQTAISMGNLKSNMSGVVKGMSVVMDSMNVEKISKTMDQFEKQFEDLDVRAAYMEGAMNSTTAGATPADQVDDLIQMVADENGLQIAGQLDSAGAVGTHIPVPAPAPQATDDLSARLAALRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XKI9</accession>
    <name>A0A6G0XKI9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ae201684_003745</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="VJMJ01000042">
        <property type="protein sequence ID" value="KAF0740855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XKI9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000257"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05581">
        <property type="entry name" value="STKc_PDK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000191">
        <property type="entry name" value="3-phosphoinositide-dependent protein kinase 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000024">
        <property type="entry name" value="Probable serine/threonine-protein kinase cot-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033931">
        <property type="entry name" value="PDK1-typ_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039046">
        <property type="entry name" value="PDPK1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF163">
        <property type="entry name" value="3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14593">
        <property type="entry name" value="PH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="32"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF0740855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="469" mass="52154" checksum="A3B1D9A491651B06" modified="2020-08-12" version="1">MVSTTSSPTSSTTSTSSAQSTQPRPTMTPADFVFGSVLGQGSFAKVYHAQFKKTKANFAVKVMDQEFIKRHRKVPFVVMERQVMSKLSHPNIVKFYCSFKDDESLYMVMELCRGGELLSLICKERDAKKEQGILEAACDEDVVSFYLAQLIVALEYIHSNDIIHRDLKPDNILLSDNGHLKVTDFGTATFGAGSSEASNDFCGTAEYLSPEVLNDQPACVGSDLWAVGCILYQMFVGRPPFRGENDYLTFQQILTHDPASMEFPDHVPEAARNLCRRLLVRDLGARLTDYDLIQSHEFFEGIDWASISKATPPVSLELTDLPTPTMDGAAPNWSISNVLSDVFSASPIESSDLPILMGENCHSRRPSNATSPYASLLENNEAIVFHSDVKLHGSLFTKKPRELLFTSQGRLIVADAKANSKQAYEWSAMQIVPKNNTTFDIRTSSVTFRITDAVHGAQKWCQLLNNYKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XLE8</accession>
    <name>A0A6G0XLE8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_003618</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000041">
        <property type="protein sequence ID" value="KAF0741046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XLE8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005660"/>
    <dbReference type="OrthoDB" id="162638at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.60:FF:000001">
        <property type="entry name" value="50S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00514">
        <property type="entry name" value="Ribosomal_bL35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001706">
        <property type="entry name" value="Ribosomal_bL35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021137">
        <property type="entry name" value="Ribosomal_bL35-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018265">
        <property type="entry name" value="Ribosomal_bL35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037229">
        <property type="entry name" value="Ribosomal_bL35_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00001">
        <property type="entry name" value="rpmI_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33343">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN BL35M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33343:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL35M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01632">
        <property type="entry name" value="Ribosomal_L35p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00064">
        <property type="entry name" value="RIBOSOMALL35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143034">
        <property type="entry name" value="L35p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00936">
        <property type="entry name" value="RIBOSOMAL_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0741046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="107" mass="11735" checksum="3D170B648AE65B4F" modified="2020-08-12" version="1">MSFLRAAFACTTGLLSRGALTPSSLAFGSARPPAMMSMQVRDMGYKLKTKSAVKKRFFVNANGNIKRGQAGKRHLATDKNRQRIRRLGQAATVTGQIKKNILAMLHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XML9</accession>
    <name>A0A6G0XML9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_003375</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000036">
        <property type="protein sequence ID" value="KAF0741709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XML9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020871"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22710">
        <property type="entry name" value="X-RAY RADIATION RESISTANCE ASSOCIATED PROTEIN 1 XRRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22710:SF2">
        <property type="entry name" value="X-RAY RADIATION RESISTANCE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="378"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="379"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="417"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0741709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="549" mass="61439" checksum="3B5A3157E843C83C" modified="2020-08-12" version="1">MPRVAPQVDDADGVGQIETLDDRLSETERIASLSSIGVVDPEQFDLPLETKTTLDGFLLLDTCKAEFPEDVSRADVNGLGLRSIVAEDLLFFTGLSFLDMSDNQVDIPLHDDAHDLLQAPLGPLGVLPALKELDFQCNALSKLENLTGFDALEWLNLSFNCLVASDVEELAKIPRLRELYLANNWVIHLPPIMDHFTRLETLSLERNNINGSDIFAALAVAPRLKNLNMSHNKITHFPQITLTQREGSGFPALSYLNLAHNKIAKECDILALVWLRVLEQLVLYGNPLAHAAVQTQDKTKLIYNPVPNMTDPNVETEREVQLNIVIAYPDTKRRKPTYKNVAIARVAQAALPTSQEFKARGQRMLKTDPAATIFPPLQRRHDDDAKVQEDEPRDGPDATFLTGVGLEDTTSPMEIASRPDKFPHVKDQKHTEPAMPSYFLTRSLAPTTEVQQHKLKTAMSSLRYQLNHPLTSHNDSDHPDMPLASRSTALHNIRQRPRRHHGPEIKSGVLATIDRAIDDVNAKLHQRSVDRSAALEKLLRKANRLIQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XNK0</accession>
    <name>A0A6G0XNK0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">eRF1/Pelota-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_002923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000032">
        <property type="protein sequence ID" value="KAF0741982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XNK0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021615"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.960.10">
        <property type="entry name" value="eRF1 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024049">
        <property type="entry name" value="eRF1_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004403">
        <property type="entry name" value="Peptide_chain-rel_eRF1/aRF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10113">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03463">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55481">
        <property type="entry name" value="N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="1">
        <location>
            <begin position="5"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0741982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="106" mass="11541" checksum="7159A32175121D81" modified="2020-08-12" version="1">MNRNAEDVRVERFKLKKLIDRLDAVRGSGTSLMSIIIPANGQISRTSQMLTEEYGTAANIKSQTTKSAVLGAITSAQQRLKLYNKCPPNGLVLFCGKCIGPDGNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XPA9</accession>
    <name>A0A6G0XPA9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Choline/carnitine acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ae201684_002830</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000030">
        <property type="protein sequence ID" value="KAF0742161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XPA9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002293"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004095">
        <property type="term" value="F:carnitine O-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000002">
        <property type="entry name" value="carnitine O-palmitoyltransferase 1, liver isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF31">
        <property type="entry name" value="CARNITINE O-PALMITOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="13">
        <location>
            <begin position="189"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF0742161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="786" mass="88127" checksum="1FD52017EAB03EC1" modified="2020-08-12" version="1">MAEARAAVQVYEGNRRGVKLLVSKEGAIDVTLHIPSPSELRSMAMRNVHYTKNLVQNVIYPVPPAIAGAIVVLFIGLVASSPDDSFWRQSSISWLIWHVGNFLTPFSSYIPRGLYVAYLTAWGSFCGLIVLMSIHRLILRALLGYRGWLYLAPKQTSHVVTIWAALIKVLGGRNPLTYAFQSALPRMSVPPLKDTLQRYLKSIHPLVSDEEYKRIEGIVADFQANAGPKLQRYLVLKSWYADNYISDWWEQYVYLKGRSSIMIGSNYYALPAKIIPSARQLARAAGIVRQFMEFKQRLDREQLQPIMLRGLVPLCMQQYSRIFSTNRIPGRDEDVLKKYSHSKHLAVNCRGRWFKVPLFRKGTHGELLSAYEIEQQLIAVSNACAPEDIVQEQHLAALTTANRTTWAEHRDTFFGEGVNRQSLRVIESAVFVLILDDSAPSNDDVLGKSLIHGNGSNRWFDKSFTVVAYANGKVGINVEHSWADAPVMAHTWEEVSFREVLNEVYDADGHCKKPATLTDATPLPPVEKLLWNWTPELNDAVHACLSTAQDAIATFDLRVVTHSAYGKTEITRTCKMSPDAFVQLALQFAYFKNTNGTFTQTYEASMTRLYKHGRTETVRPVTDQSKAFVLAMADPKVSNEERRKLCWAAGEAHQDLYRNAMSGLGVDRHLFTLYCVSVGLGIDAPFLKDAMSRPWRLSTSQQPQNQTDLFGKIKSRKLVADMSECICPGGGFGPVALDGYGVSYMIAGDSNLFFHISTDKTAGNTSSESFARDLNAALTEIRAIWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XQ92</accession>
    <name>A0A6G0XQ92_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Oxidation resistance protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_002384</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000025">
        <property type="protein sequence ID" value="KAF0742683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XQ92"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003836"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17671">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006816">
        <property type="entry name" value="ELMO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004012">
        <property type="entry name" value="Run_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037213">
        <property type="entry name" value="Run_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354:SF62">
        <property type="entry name" value="MUSTARD, ISOFORM V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354">
        <property type="entry name" value="NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04727">
        <property type="entry name" value="ELMO_CED12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02759">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140741">
        <property type="entry name" value="RUN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50826">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RUN" evidence="6">
        <location>
            <begin position="57"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="5">
        <location>
            <begin position="255"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="7">
        <location>
            <begin position="706"/>
            <end position="867"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0742683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="870" mass="98774" checksum="E8969C8D2A80D178" modified="2020-08-12" version="1">MLSRIAAWLVPSAAPGDDENSKKRYELLAQLKKAVMDVCNWYEEKNKLDFQGKRPLEEEDIGMHDLLLCIQSCLQHGLRDDATSFWIVLNFIQTTLTDPTEPICLAIKEASEGSQTDNGKCRYWVRTALNRFLVEPTITAAISPTNESFIRATYDDHALLRCSEAATIMVQLLSYLRELSFNLQLSDREFSRRRTSLPKVVSNVLHAHGVDLLFEKVEALVDDVASQAEEYMSTRARALSDRQKGIKPWQHVFNVELSFLVRNPYHTRYAFINPYLAVPNFLIECLDYLQLNASTPRLFRTTVSQVYVTPVKDYIETHGNLPKQLDPHVASTILIEFLRHIPEPLITSERYDAFISSSRMTDPADRVRNLTCLVADLPVEYKVTMELVFGALAKFLTHSEENGLNIGTLSIALAPAIVRKRETRENKTQMQSQEVRMAAIGAHVVELLVEHHETIFQPVREMIVKAKEEFTKKQEFLNTFAIMVKQPVEADDPTLVAIWSCMTKYQHAVANTSNNNGEPLDKIELWHSFGFREAHIVDNFQSGGQLMARCVAYFLENDETACQLMVQRLNEYNMPVAFAALVMVLLNVLKLAPTPQQPVLDFTILSMEPFWEIFDEKDFFLRLFGLSVRVFDHNWTVGSRADFGRILEETEAQMAWLLQRSPSSFDDIVDDWVLYRKQATTKAATMIEESIAIQNQFTAKLIGTSSILSGANLSELNEVLPITCQLCKWKLLFSNEVHGSSLNSLLMLCKGQSPTLLVLKEDNRTIFGGFASDVWHTSANYYGNGESFIFRFTPLGKLEKYSWSRKNNYFQLCNEESLVMGGGNSFGLYLDADLVHGTTGKCDTYSSEPLVPGENFACTHVEVWGYTMEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XQS7</accession>
    <name>A0A6G0XQS7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Choloylglycine hydrolase/NAAA C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_002280</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C59 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000023">
        <property type="protein sequence ID" value="KAF0742884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XQS7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020181"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.60.10">
        <property type="entry name" value="Penicillin V Acylase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029132">
        <property type="entry name" value="CBAH/NAAA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052193">
        <property type="entry name" value="Peptidase_C59"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35527">
        <property type="entry name" value="CHOLOYLGLYCINE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35527:SF2">
        <property type="entry name" value="HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02275">
        <property type="entry name" value="CBAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026180579" description="Choloylglycine hydrolase/NAAA C-terminal domain-containing protein" evidence="4">
        <location>
            <begin position="18"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="382"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Choloylglycine hydrolase/NAAA C-terminal" evidence="5">
        <location>
            <begin position="27"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0742884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="416" mass="45012" checksum="68667CC2E08BC1EA" modified="2020-08-12" version="1">MALFRWILTTMAAVVLGDSDILLQYRDEIISARTMDFALDLTTAVEIVPRGTFIQEPAVQRAPDTPDYSWTTTYGFVGFNLMGANIAADGLNEAGLSAAWLYLAGSEYPPVNTTDSRPVVASLVTYILGNFATIDQVRAGLDQIQVAAIDPRLITVLTGVADVPASFPLHVAVHDARNQSLVIEFIDGTMKVHDNPGGVLTNEPSFPEHLASVETLDKQSDLPAGYSSAARFVRLTALNREASFAYFANTSYSVTSTPGQAGIAAALHVINTVAIPTGYIGEGAATQYTVVRDHVRRHVYFLSTQNQVPRRLDLTAIDFSKSTNRKFLPVTFGSWYVDVTADELASTRQTSDLPGRAKDQVRLRGIPEPHTIAEAHLARDTWAALAIAGACLAGVAYIALEMRRISRGGYVALAHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XRL9</accession>
    <name>A0A6G0XRL9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_002054</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000022">
        <property type="protein sequence ID" value="KAF0742990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XRL9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008400"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="2">
        <location>
            <begin position="171"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0742990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="215" mass="23713" checksum="DFCF6151752ABFD2" modified="2020-08-12" version="1">MQPPFYSDGLFKAMTFAVTAASIPHRGSAPTLYTVVVGNKASGATITLTKTTDDFNKFGVNLCAALDLGHVCEATCPWFFAHIKASTRPKHNWCLPDAVAVERNLQTFDDLFRAVRSFLQSSANTTCHRATTRIPNVLFDFLFDHMDYIDPAVFAEPPPTKRRLSFQDFRCSLCSVPHSSDVTTLTCGHAFHDECILNELNKHMTCPSCAMAAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XTQ7</accession>
    <name>A0A6G0XTQ7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_001472</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XTQ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002710"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002711"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.680">
        <property type="entry name" value="GOLD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051064">
        <property type="entry name" value="SEC14/CRAL-TRIO_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23324">
        <property type="entry name" value="SEC14 RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23324:SF83">
        <property type="entry name" value="SEC14-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="572"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="2">
        <location>
            <begin position="760"/>
            <end position="865"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0743826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="884" mass="101673" checksum="D52CA407BDE908F1" modified="2020-08-12" version="1">METQRGEFVHDIRLASHAPGVPYPVPEEVQQIESNKKIAKAAAEQERQRRMSEESFAHVQSELLREKAKQEASILVENERARRMSQEHLAQVHSDLLRESSKKLVVEEIETERSRRVSQENIAQVHSELIRSSSRKQVAEAVEDERSRRINGEQIAQVHSELVRKNSLKQINDDVEAERKSRMSQDKIAEVHAHLLRRNSVDEAVQLAESERQRRILEESRRQEMIRAPQFFYTATEYAKGLPYPVPEEAEHIQSNKAIVEKAAEEERERRLEEMHSHECESAIVREINIEYAIACMETERIRRVSQHNMAEVHNELLRDHSKKQVVELMEEERGRRVSQENLALVHDELHRERSKQRVVVEIENERHRRMSESSIAEVHSHLLRRNSIDKVVQLAEEERERRIQEHQDQTTNDQKTRLEQQLHAVGAMETERARRLSTSQHLEKVASLSSVFGERGSTVSDLDAAVLEPLPDSDDMDYPELPVASSNPQQEQKALYDLQMALKDVLKPSKNETTDALRNLQLLRFLRGHKGNVEIAAERYRTMLELREKHHLDAIRESIVLGNMTAVDFPYYEKIKRYVPAAMAFDVEDDDHNVFTFEKLGAFDLYGLVVNVSDDEWLAYCLHELESRAWMLDQRSLEHKTLVRCTTLRDLDGFSLTRVTRPVLHRVQSIISLASACYPESVHKVVFLNTPWIFHTAWRGIQLWLDESQRQKICMLKRGDKIDAICPLSKLPVLMGGTNDHVVLPPTGLLGKDSYALLRENGATEAEIRARDVLTVPFRVNANDTLCWEFCVLKYDVDFAIKFRTQGDGGAVELDVQGWEKSRFVHGQVEAASWTAPAAGVAVLCWDNSFSWTRAKTICYKASVAKTLEPDTSFIDISGHGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XU21</accession>
    <name>A0A6G0XU21_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_001268</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000010">
        <property type="protein sequence ID" value="KAF0744126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XU21"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012628"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169:SF2">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0744126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="310" mass="35074" checksum="427F33509A3FCAE2" modified="2020-08-12" version="1">MDGVSAYTFRPLDNVVHVDEKWFHLAKLNQNIYIIPDEIVHKRSTANKNFIPKIMFLAAVAESRLDSLTGKYFDGKIGIWPLIQEVPAKRASKNRPRGTPIKAPITVSRNVYRDIVVNSVIPMIKEKWPEGSSKTISIQHDNASAHDIRHHPDVIAAGCSDGWYISIVNQPPKSPDLNALDLGYFNSIQSLQYQKQAQNIDDLVSAVEASFEELTSDKLENTFMTLISVMKAIIEHKGDNDFKIPHASKAKKRRQGFFGEPEVVTISSVEEATEVLANMYERLHDEGSIDERCDLFNDVGIPEEIEYYEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XV23</accession>
    <name>A0A6G0XV23_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">serine C-palmitoyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ae201684_000885</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.50" evidence="5"/>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XV23"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012053"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004758">
        <property type="term" value="F:serine C-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF2">
        <property type="entry name" value="SERINE PALMITOYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="13">
        <location>
            <begin position="141"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="519"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="520"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF0744404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="538" mass="59103" checksum="2856EF0A9FDEFF90" modified="2020-08-12" version="1">MSQYNASWWGEWWTANAQPIVEAYASRDVGQLWRVLERIPWTYFNYIKTIYERSPEHVIIETFLIVFICYIAFVKRSPSRPKGDTGEKLTEAEVQALVDEWAPEPIVPSNFVPQPDFPTCIGVVEETPGSHIKLQGVKEPLINMATLDFLGLASRPEIKSVARSALTKYGCGSCGPRGFYGTIDTHEILEKDVAGFIGTTDTITFSDLEATCSSVIPAYAKRGDLVVVDDGVTESILIGVDLARCTTLFYKHNDMEDLERVLKSIRDADKKARRPSDAQRRYLITEGLFRNTGVIVDLPRIVKLCETYSFRLFLDETFSFGVLGATGRGLTEHSNVSVDDVDILCGALGTSLAGVGGFSTGSQLVVDYQRINSAGYVFSASAPPYTSAVASESIRIIRREPELLKKLRELSSQAHGLLSAIPGLQVLSDPVSPVIHVRVAQSLAGNESKEWMSKVCRAAVEEAKTRGLAVVSPYVKPNRLTETPLATVRMTINANHSPALITSAVKILVDALQAAVDSHSTSKRDLRKADSTPKKTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XXL3</accession>
    <name>A0A6G0XXL3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">No apical meristem-associated C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_000290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XXL3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010829"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45125">
        <property type="entry name" value="F21J9.4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45125:SF3">
        <property type="entry name" value="NO-APICAL-MERISTEM-ASSOCIATED CARBOXY-TERMINAL DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0745259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="26485" checksum="6B0886EC94116098" modified="2020-08-12" version="1">MSHNNPCDARALMSAKGRQCGQSNFKPEEDEQLALAYVKVSTDAAVGTDQTADKFWAKVHNKFNYQRLAGTERSQNSLLNRFNNVLQKEVSKFVGHLAQSLREYHSGWHMQDYVEDAKRKYKDTKKSVQDESVDVVAEGQPTLAQRPLVGKKKAKKLRIEHERGMSSIAQLARIADATEKKNGFIKEHIMMEVFKIDPDSEESKRFFSLKRKQYMNEIEQEMNRDNEDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XXV7</accession>
    <name>A0A6G0XXV7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_000445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XXV7"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0745426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="122" mass="13684" checksum="C076C2A194F6F6BC" modified="2020-08-12" version="1">MRIEAYGIEKSPRNALKGGPLEVQSRPPLKLGGSTSYESALLSTLRYKLQVWTSPRTQRRPNLTATRKRMHSKKYRSNKLKWLPDGELCPEFTKGEVGDVAFSQRQGSAVSSSIEGEMVSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XYS4</accession>
    <name>A0A6G0XYS4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_000192</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000001">
        <property type="protein sequence ID" value="KAF0745744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XYS4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019198"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22702">
        <property type="entry name" value="PROTEASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22702:SF1">
        <property type="entry name" value="PROTEASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026135322" description="PA domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="4">
        <location>
            <begin position="57"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="4">
        <location>
            <begin position="212"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0745744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="388" mass="42577" checksum="3468D3F3AD27ABA3" modified="2020-08-12" version="1">MRTSFIGVLVFTFASLAVGTDESPFWGRIYLRHGIAPIQYFRDSYGGNIPLEECEFVTPANNFGCSKFSEDDLALVTNSSLVVLDRGVCSFEEKSKNVQAAGAAGLIIVSDTEEVVRPVAHIDKGEIDIPTVMVRKSGGDQIRVAANREAVFGKLIPMICPKSICRPFVPRDSEYMSSSVRGGFIYSPDTKTSEWEFLASTFGSPLLTQHLPVVQANPQHACSELTNDVANHIVIIFGHNANCSFLTQISNAQVAGAASVLFVQGENEALIRPSVAEQWAAYNITIPSGMVSKKTAREILRNDIHVVLQEDANVANAWEAIAQLSDVGSWPKRKNRRNAFLVDLLKRHGHTLARKLAIRSHFINVVGGSKVAWDAIEDQVKVSRHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W2L4</accession>
    <name>A0A6G0W2L4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_019244</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000551">
        <property type="protein sequence ID" value="KAF0721015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W2L4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018781"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000074">
        <property type="entry name" value="Multidrug resistance-associated protein 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="176"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0721015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="411" mass="45465" checksum="A32D98FC1E36DB56" modified="2020-08-12" version="1" fragment="single">VPLVWLFQKIQVFYNRTSAELKRLESISRTPVINIISETINGITTIRAFGMTRTFATKSREVLDHNQSYFMIYRASSRWLQMRLDWVSTVVLAGVSFISVASKSSIGVTAAGLGLTYASQMSSFLSRVTMNLCTIENIMTCVERLEHYNSLDTEGDTCEEMEATPAEWPAQGTISFESYSVRYRDHLDLVLRDVSFVANGGEKIGICGRTGSGKSSLMAALFRTVEAASGCIKIDGVDISQVNIHALRSRLTIIPQDPVLFSGSLRFNIDPSKQVADADLWAVLKKVHLAGCLEGGLDFQVAEKGSNLSVGQRQLFCIARALLRQSRVVVLDEATANIDLESDRLIQKTIKECFRDVTMLIIAHRLDTIIDSDRILVMDRGSVIEYDSPQVLLAKEGSVFAELAKQACVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W3T2</accession>
    <name>A0A6G0W3T2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_018976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000370">
        <property type="protein sequence ID" value="KAF0721696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W3T2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017884"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0721696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="47047" checksum="A805249A5DC8EB7F" modified="2020-08-12" version="1">MMSYADRRREAARKGMAKLREARKKEIKALTSQVQNLQVALDHLKAHPEEQHQSIQPFAYARRVLDQHHDDALREQVVIRNRLIQSERIAKKKRIDNHKAVVLAAQAHILRTEGINMELLTRLTGQQQLKDFLEDWLMSQSPQKGRPLLMETILLPDDNGRRNGCYFMTNRAYNLSKQKYPPRKTYEEEVEDFLEVKIHLDEDDRETCIYAIESHVPFTVDANFENVAKTWWFDLVESNPLVEASVLERFEDHIMYLKHEYSSYKYRRLCVAGVFLDHDEDRITITQTGIAIDEHFPFVQGESRANGNQWIVFQHVTDRLTIVRWTVVNFCPMNANGPLSLLEIALTSHCGAKPEDSEEVLLAVEKYLVGLRDQFLRRCSRFKLEPTTIPARDLPIGSLSHTKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W3W2</accession>
    <name>A0A6G0W3W2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Bardet-Biedl syndrome 2 protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_018969</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000370">
        <property type="protein sequence ID" value="KAF0721689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W3W2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006363"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034464">
        <property type="term" value="C:BBSome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016616">
        <property type="entry name" value="Bardet-Biedl_syndrome_2_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055381">
        <property type="entry name" value="BBS2_CtH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029333">
        <property type="entry name" value="BBS2_GAE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055380">
        <property type="entry name" value="BBS2_hp_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029429">
        <property type="entry name" value="BBS2_Mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029430">
        <property type="entry name" value="BBS2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055379">
        <property type="entry name" value="BBS2_pf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32465">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32465:SF0">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23351">
        <property type="entry name" value="BBS2_CtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14782">
        <property type="entry name" value="BBS2_GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23353">
        <property type="entry name" value="BBS2_hp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14783">
        <property type="entry name" value="BBS2_Mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14781">
        <property type="entry name" value="BBS2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23350">
        <property type="entry name" value="BBS2_pf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF013684">
        <property type="entry name" value="BBS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ciliary BBSome complex subunit 2 N-terminal" evidence="7">
        <location>
            <begin position="20"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Ciliary BBSome complex subunit 2 middle region" evidence="9">
        <location>
            <begin position="155"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="BBS2 GAE" evidence="8">
        <location>
            <begin position="380"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="BBS2 platform" evidence="10">
        <location>
            <begin position="473"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="BBS2 hairpin" evidence="12">
        <location>
            <begin position="575"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="BBS2 C-terminal helix bundle" evidence="11">
        <location>
            <begin position="677"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0721689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="710" mass="78208" checksum="CBA5428661DF82A8" modified="2020-08-12" version="1">MLPSFKLHMHHAILDRLAKVGKYDGKHPSLTCATSSGKVFLHNPHEKNDDEADQAVRFLNINREVSAIAVGKFRDQDAGDTLIVGTHANILGYNVEKNSDTFYKDVPDGVNTMLFGSLPNIPSKMVMVGGNCSIQGFDREGNEMFWTVTGDNVTALTLCDVTGGGKDELVVGSDDFEIRAFQAEDVVCECSETSRILDLTTIQKQLFGYALDNGTVGVYKNNHRVWRVKSKNVPTSITSFDINGDGELEIVIGWNNGKLEARSIANGAAVYRDHFSSPIAAVLAADYRLRGTSEIICCATDGEIRGYAYDGADGRKETATILMDDITAEEKEVQALIKSKAHLMNQLKAFENASAKTTKGSSVRVATSTKISIVPSTTISHSNVELTVSTDNDSIIKMLVIFDYDAGIFDGESLVIRPATPGSKIQVALPPLKKSIAVTLYFRVGNRGNGNMFHVFEETFALPKFAMYVPLKSLSGERPTGCVKFKKPLRMPQFGAWIKSAFLPSDETTFNELDTTSGNVDFIVKHVVDNSIVAITTTTTDMEIRVNDMTVAAELIQDLCHHLQIDELESIADFPAQFAAFRDLLVRVDDYNSIRLKLTGDMADDSNQIKHLVIRAEDARIINDMKGMRSFYSELFTLNNQLLGEYTKRATNHQALLDALKDVNSMIQLAARLRNGQAKAAVIVACRKAIKANNIHALFYIVKTGREESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W591</accession>
    <name>A0A6G0W591_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helicase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_018642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000345">
        <property type="protein sequence ID" value="KAF0722162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W591"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015695"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005114">
        <property type="entry name" value="Helicase_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37066">
        <property type="entry name" value="HELICASE-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37066:SF1">
        <property type="entry name" value="LNS2_PITP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03457">
        <property type="entry name" value="HA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase-associated" evidence="1">
        <location>
            <begin position="160"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0722162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="314" mass="36166" checksum="DC69343587769E98" modified="2020-08-12" version="1">MGFIWDTVQDILEKNLLVIETYKAIHEDLLVKTTFVEPDQDPAWPKDTWNMKLGYLVASCRKTKASLPPKILDALNTMGFVCKVRDQGTGPGRPPRISMKKQNQILELFKLIPSSSKWSQHLHGCSMNTTYFRRAYRLGLLEASIVAKLDEIGFVWDVSQHQWSLLMEALEIFKKIYGHVDVYQVFEVPEDDPEWPNYLWGMKLGSRVSSIRSGRTKLTLEKRQELEKMNFIWDADELHRNLILLALKTYKEIYDNLYVPQKFVVPCDDPAWPSGTANMNLGVVVNNLRKNRANLSNALKMGLDALEFEWSGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W635</accession>
    <name>A0A6G0W635_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_019114</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000397">
        <property type="protein sequence ID" value="KAF0721494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W635"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002662"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015385"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="251"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="486"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="125"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="511"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0721494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="543" mass="59710" checksum="7C047C777B119ED0" modified="2020-08-12" version="1" fragment="single">MDVEMQQGEEPTTSRELISLQARRAAQHSSSTKERESTSLLEIDTSEVVDDARTKRRASPLPPTAMVAFATSPQTSTVTMIEDDRVSIPSEGTTTPHTSPWRQHDNNRIQEIVRTQLALQSTELFRQLAVSNANAERAIEVAEARAAAAEEEKERQAAVLAKRLHDADVVSQAQQQVLAGATRQYQEMAAQLAQAKVERENALYVATLSTSEVNRLNSEENEANNRHAMESARQAQHVDFVTASATDAIQRQAEAAAAESDTSEWKGNDNPPAGNGVEARGSGDGDGGHGGVHQVNSNSRAPKMKTFKCTPFSGEEVYPGLGHDFESWHVTFQRAVTRDEVFEGSTWEEKHLFHALISCMSKDAERFVTQSETAWLNEAGNRYGYNFVVHKLRQKYASHLSNGELISKMMAPKRWAMSWDEHIVYLRHLQRMLASSDAMVLDMFCKYSCPQYTPSLIACVDLQNKGDPNEMEKALKTLIELTGTGVNFGKNRPNPSQAKPNYQGRANMAHGGRGGGRGGGRGGRNGGRGGGNTGRDMTNVTCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W6H5</accession>
    <name>A0A6G0W6H5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial import inner membrane translocase subunit TIM17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_018216</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000326">
        <property type="protein sequence ID" value="KAF0722738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W6H5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000646"/>
    <dbReference type="OrthoDB" id="2261329at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485:SF0">
        <property type="entry name" value="AT05822P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0722738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="16569" checksum="E01EEA31C14204F9" modified="2020-08-12" version="1">MEREPCPWRILEDMGGAFGMGAIGGGIFHSIKGARNSPPGERFRGAVFAVKARSPMLAGQFAIWGCLFSSYDCSLAAVRQKEDPWNSILAGAATGGTLAMRSGPRAALTQAFIGGTLLALIEGLGILLGKMITPPPMEYTDEHGVDTSEQQLAPPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W6R3</accession>
    <name>A0A6G0W6R3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycine zipper domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_018175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000324">
        <property type="protein sequence ID" value="KAF0722784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W6R3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005548"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026305373" description="Glycine zipper domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0722784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="19538" checksum="3554C6149DF30CE1" modified="2020-08-12" version="1">MRFFTPLALAASTVVAFHQTYQDSPAMLAYPQRGSIDSTVNVQRALQGNGFQKRTYGRRLVSKNRKLAEGKYEKKYRGRAEACGAICGGAAGAAIGAGIGSATFGAIPGIGHVGGAVTGGIGGAMTGATIGKVAAGNWGAKKGRAKDERLAASGGQSSSSGGSQRQSPSQIARSTNVQITPQRSARRGPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W7J6</accession>
    <name>A0A6G0W7J6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_017950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000317">
        <property type="protein sequence ID" value="KAF0723079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W7J6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010350"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0723079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="287" mass="31881" checksum="CA073A48B6FE6AAC" modified="2020-08-12" version="1">MTKRARADSEMPKDVVLNLAKVCFASHEDPFRVKMALTEGDLPMRLWLEDKKSKLQWECNVKDFQDRKPKDANYEVPAKAVIEGLEGALSALASSNGKTDKYTVELKSSKHGHLELVAKFRFFPSLEAVYSFDLAPVHIEKIDILEAKLRDLEEVGQSPKKIIGLQARTIVGTPGGNFVHWELVSLNKSHQVMDLDGDTTVVLYTPGLYEIQVTGTRIWSGGYCLTIVVDDKQVASTPIQENSYCNSLSHLLVTTGEMTKFKVLCHGVGHPLSPGATMTVLYIGKFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W8T2</accession>
    <name>A0A6G0W8T2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_017596</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000304">
        <property type="protein sequence ID" value="KAF0723516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W8T2"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0723516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="276" mass="31313" checksum="6EED79E47C7FDD8F" modified="2020-08-12" version="1">MKIRRHEWTSRNVTPTRTKQLSLGCLITRPWLEQLDHPWNDTWRVEEHSASEELGIHLFGQSACHLVELGELTVVATCDGEPLKVQQDGHPNKTAYRSRELVAEEKDPLSNEHVISSNGSASMRAFELDNPMRTMKSGSPYFVNLCSPATYCHVSLPTLAKIKGSYLKLCYLVMKRWHLSRMDSVEEILPSVAPFNRVAAWFNGILDVSIGKNEAEKPNIIILWLKHILKVSTQGLYSKKAKLKCPRDKSAKMQKEVVHRCLVLASSIRLIDSSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W8W5</accession>
    <name>A0A6G0W8W5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_017517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000300">
        <property type="protein sequence ID" value="KAF0723613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W8W5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004742"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0723613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="262" mass="30794" checksum="CB4EF0D3ADACF0B2" modified="2020-08-12" version="1">MDHDDWKTPGNIRKFCSRFAERYFPTATEQQAEEHVDRLADQQNDQLSDQQADQQDDRLADQQAAQQIDQLADQRADQQNDQLIDHQADRHVNQLADQEADEQNNQLTDQQADRQDDQLADQEVNQQVNELADQEANHHVNELTDQQATQHINQLIDQQPEQHIVQLTDEPLIDRQTERPVNQLTFGDLFDEDLQNSDGLDETKRKRPQLHNDSESADEDNYRKAYTHIDQSLPLRGRTNKARHFWTSKVFQWLQVQQWNSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W9A2</accession>
    <name>A0A6G0W9A2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="6">3.2.1.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_017911</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="6"/>
    <dbReference type="EMBL" id="VJMJ01000316">
        <property type="protein sequence ID" value="KAF0723107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W9A2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020167"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF34">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026141491" description="glucan 1,3-beta-glucosidase" evidence="7">
        <location>
            <begin position="18"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0723107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="118" mass="13097" checksum="9C93B7683FD996D7" modified="2020-08-12" version="1">MRHSIAALSSVAAIASAAHIQHDIRAGRVKSRGVNLGGWLVAENWMTTGAVIWQGVPRPAIAQGEYTTMSYWGAQQGTSRFQQHWSTFISEHDIRQISLAKLNTVRVPVGFWIQDCDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W9Z2</accession>
    <name>A0A6G0W9Z2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_017193</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000286">
        <property type="protein sequence ID" value="KAF0724027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W9Z2"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0724027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="72" mass="7862" checksum="F43C41DBBF4B7C01" modified="2020-08-12" version="1">MKPNGLQSLDDILEFTPNMPKANAVREIATAVVLALTAGAAWKSYAVADLKSFDDYYKSLKTQEKAPANDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WBD7</accession>
    <name>A0A6G0WBD7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="4">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Isoleucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Ae201684_016777</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>tRNA(Ile) + L-isoleucine + ATP = L-isoleucyl-tRNA(Ile) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Part of a multisubunit complex that groups tRNA ligases for Arg (RARS1), Asp (DARS1), Gln (QARS1), Ile (IARS1), Leu (LARS1), Lys (KARS1), Met (MARS1) the bifunctional ligase for Glu and Pro (EPRS1) and the auxiliary subunits AIMP1/p43, AIMP2/p38 and EEF1E1/p18.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="4"/>
    <dbReference type="EMBL" id="VJMJ01000267">
        <property type="protein sequence ID" value="KAF0724569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WBD7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015770"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07961">
        <property type="entry name" value="Anticodon_Ia_Ile_ABEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00818">
        <property type="entry name" value="IleRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000044">
        <property type="entry name" value="Isoleucine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000414">
        <property type="entry name" value="Isoleucine--tRNA ligase, cytoplasmic-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000004">
        <property type="entry name" value="Isoleucyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000050">
        <property type="entry name" value="Isoleucyl-tRNA synthetase,cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02003">
        <property type="entry name" value="Ile_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033709">
        <property type="entry name" value="Anticodon_Ile_ABEc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19302">
        <property type="entry name" value="DUF5915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="16">
        <location>
            <begin position="27"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="17">
        <location>
            <begin position="704"/>
            <end position="870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00063494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF0724569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1172" mass="133063" checksum="37C71C41B51BE24E" modified="2020-08-12" version="1">MAKPTSSAHAHVRLPERLSFPDEEVKTLELWQEIDAFHTSLRLSKDRKPFTFYDGPPFATGLPHHGHILAGTIKDIVTRFAHQTGHYVERRFGWDCHGLPVEFEINKKLNIHTKDEVLAMGIDKYNNECRSIVQRYTKEWETTVARLGRWIDCKNDYKTMEPWYMESVWNVFATMFKKDLIYRGFKILPYSTACNTSLSNFEANQDYRDTPDPSVVVNFPLVDDPNTLLLAWTTTPWTLPSNLALCVNADLDYVKVKDLKSEKFYILAEARLVQVYPKMEKKGYVPEFERVETFKGATLVGKKYVPLFDTFASWPNAFRVLSDGYVSSDGGTGIVHQAPTYGDDDYRVCLKHGVVTKTELPDPLDDNGKFTKEVPLVAGLHVKEADDVLCKDLKSRDRLVSKSTFVHSYPFCYRSGTPLIYRAVPGWFVNVEKIKDKIIANNQKTYWVPAFVKEKRFHNWLVDGKDWNISRGRFWGTPLPLWVSDDFEEIVCVGSIEELKQLSGVTSITDLHREFIDEITIPSKTGRGVLRRVPEVFDCWFESGSMPYAQQHYPFENKEKFLKGFPADFIAEGLDQTRGWFYTLMVIGTALFDQPPFKNLIVNGLVLAEDGRKMSKSLKNYPDPADIFAKYGADALRLYLINSPVVRAEPLKFQEAGVLGIIRDLFLPWYNSARFFVQNVARLEEDTNATFVPSTGIEYTNVMDAWIIAALNSLIKFVRAEMAAYRLYTVVPRLVDFIDQLTKWYVRLNRNRLKGSEGAEAAQVALSALFEVLYTLCKLMAPFTPFLTEYMYQFLKLYHPKSQEITSPNTPEDSEGTAKSIHFLMIPDFDSGRLNAEAEARMVNLQSVIEMGRVVRERRNISLKNPVKRVIVVSSDAKVLSDLKELSSYIHDELNMRDLEFAADEKSWCTLKVEVNNKVLGKRLGKALSSVKKQVEGLSHEQALAYQTNQTITLEGDIVLSGEDLFVKREFKGDKTIYEADVSADGRLMVVIDVREDNDLKSQGYAREFVNRVQKMRKKAGLVVGDKIHVYFQERAGKDSPITEAVKQFVSTVAGTLGTTPAPLSLKPKDSVTIISEVCEFAGSSVDILVTRPAVLFTDDDVSTDVAVQNARIFVATMDYSKFRDTLTSDGSVTVTIQEEVVQLVNNKDVFVDPKDKVANTAALKSSFAWML</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WBK9</accession>
    <name>A0A6G0WBK9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_016700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000266">
        <property type="protein sequence ID" value="KAF0724634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WBK9"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0724634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="329" mass="35794" checksum="E0F94ABF007D5EC6" modified="2020-08-12" version="1">MPLDILPPCIHWLCRPLAPTVDLTDEVKASVDLEQGVWAVVVPEFDTAEDSRVMGKHAVVSPGKLMKGTIVIQRQTGAFEDTLASLSQSFVALEGALSKTGKSKWTCGVCLGSIGPRFTVMKCAGRRIWTSPLSHDCDSVSSLYNMEEKSSFARPSMARSRANRAGTRLLTDHVFLDQILQEMVAKANVFGSTMRGGSWRVHRSLTRSSVNQTMDFAASAAAMYSTSVTTAAPANMMTNPDMDLLSFKSFAKSASQYAVGGPVLEHAFGHAPVRLSPGVAVADDVDAKDEAQFALVRHLERALDGLSDFIEFMRVFSRQCDIVDIDCEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WCE2</accession>
    <name>A0A6G0WCE2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_016972</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000273">
        <property type="protein sequence ID" value="KAF0724308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WCE2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021494"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="447"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="284"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="455"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0724308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="981" mass="110707" checksum="9D5ECEE4CF0B07E4" modified="2020-08-12" version="1">MEYHSLSPRNRSQYTTQRIQQLDCVEKPHWRLEENKDDNTHAISLTILSTYTITSLQTAKYHHGFHKAVLCVEVFKQLLYNLDREALSPLFIFCEDMAKFIDGVSKTQALTTNSSQSEADSIGKVVVPPKRHQTVVAPVPRAPKRFIELPKQERHVLRVAHYLKEFMSKLVSGGSPRAGGKLQSRRVPLIVESHDDDVPPIKLHTIKTKLRNHKFFSELPTVLLADSGGAINTHQAFASYFLCLHEVVRSTSYHSAELAAGAFDLLGEILRAIQANVIEVMGHRKKLRADIRELRIQRQTLRSEVAGMDAEAQAIVAEAVKLSTVLSYIEFESSALVEECNWHDVCKDLLLNTIKKLREAVNQPPLWYVTPDGSTKALEFGTSILRAHNAQHIQTLVHLLVLSRSYHHVRMSAHGIVMEAFPERKLAKLNHKDRAKTLRMHLMNQRPIEDGNSQTSVAVAPPATPSTPASASLHQVSEAELVALASIQESLRAVEIFMRDQSFREMTFITSGVQTQISEPSKPATQKSDPTRLSLPNEVAKLPLSWQTSFSLLEDEEPVVPLTKDEMHAIVSAMYGHYENVVSTGTTLSFRDFVVVYFFVHDKTGDQTTQEGYSAQRACARFLVSIQYHVENVVALDWLGCFAAFVGISKNLTLPIPRAMDAFLSARRSLLASAVIRQRVPSANRALWVMANDINHSSGYTLHDSVKTVLSSFTRSSEAYTNVLLDKSTAVELLLELDDGGRDIQRAQVLHIEAALVILMQAWIREHHHTRSTLERIFSATLSNNDDRKTLAYDEFVVTMGFLDATFTPARLTTIYVQATDGDSANDVGEASVDRLIDILYESDLFSESKKPWLTLSPMQLVTQRNWEESIDGLNAMWRHNRERILDRLGELKTNQVNLTRVQTCFDRHDKFVRLLEAASDTNEVSTAVDMALYAFHFLQQDITATMTFAKQPKQTKVVRVVCFRTNILWKKYFASRRPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WFP7</accession>
    <name>A0A6G0WFP7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_016251</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000247">
        <property type="protein sequence ID" value="KAF0725234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WFP7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005785"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052050">
        <property type="entry name" value="SecEffector_AnkRepeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586:SF3">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0725234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="309" mass="34732" checksum="B389EDF6C3CB28E9" modified="2020-08-12" version="1">MAHVLHSRDLLARIFSFQWGLHEDMLVFQSLLSSPTALQDPAHVHTLVSKWLILQRNIEQSLHLLVEVMPSMRVILAQDAIYAGNVGYLSRLHALFDLRSLQTPLMDVAARFNRLEILQALHAVPQHDYGCTSRAVFDACSHGHVQVVEFLFRELRSLWSLKAAACAAKRGHLHIIEWIFERRAPMCMVQALKGAASHGHLEVVKYLIARDTTGGSGLDALVYAAKGGHFHVVEFIYETILIHESADSGFPFFAAALCYAINGGHDAIVAYLTSKSEPEFMDDMDLFMQHEVYQPQEAKRLRLSTHLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WFV7</accession>
    <name>A0A6G0WFV7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_015860</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000234">
        <property type="protein sequence ID" value="KAF0725707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WFV7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016898"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="378"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="70"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0725707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="473" mass="51152" checksum="A24DE31FC910DDEC" modified="2020-08-12" version="1">MASSGSSSVSQQAERIFTFPAMKTYNAEPAIRQTSHDGVVIAMPKPAVFTYTPLLQREDSSSSPSQVNQRVLVSSVANFSTAYNLAIIGSVLPLIEEKHPSTDMRIVPLISACCLVGAIVGQLIFGYIGDVMGRKKGMILTLALSILGATASAFVPKNESIYLSLAICRFILGIGVGGVYPLSAASAAEGGGSDAVLNNKRVAAVFSFQGWGQLASFLLSYMLLNTSLRHVWVWRILLGFGALPGLFVLNAAIQSEETGAFLKSQHDPNKMSLGESIRVYAKEFIGTSLGWFLFDITFYGNVIFTPVILDQLYQGEATTIVDIAQFSVFTSLIALPGYYMSYFMVGRLDFKQIQMQGFFVMALLFLIMGLFYDTLESLKMLLFIMYGLTFFFSNFGPNVSTFSLPAELFPSAHRVQLSGMSAAAGKLGAAVGAYWYGWIEATSSVAMVLVISGLVSALGLAVTSFFIPSKRYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WFY3</accession>
    <name>A0A6G0WFY3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ankyrin repeat-containing domain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_016025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000240">
        <property type="protein sequence ID" value="KAF0725512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WFY3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019252"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052050">
        <property type="entry name" value="SecEffector_AnkRepeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586:SF3">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0725512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="364" mass="39886" checksum="F1DE0644FCE02D34" modified="2020-08-12" version="1">MIRSTLLSMDILTSIVQWQHGLNHDMLPIARFPISSKPLTILDFTIVESCLKPWLATYGTSRLGLLFESLPHSQRLVVFYFVCSGQMQSLRSLKVKFNEVPEDLQAAAAAFGQLDLLIYLQETMGNMSSSSMLAAATQGQLHIIQYLHDNGPRYYSISVLDTAAASGQLAIVHYLHKVQIYECTTAAMDGAATSGHLEIVKFLHANRTEGCTRAAINGAATMGHLEVVQWLHEHRTEGWGSEAVAGAAQNGHLDVLEFLHMTKPRVGSWMLAMDVAAINGHLKVVQFLHANRAEGCTSKAVDGARANGHADVLAYLTHHDDELIRRQCCVCGLIKPRNHACSAMESFSKSRQGQIVASSSSYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WG21</accession>
    <name>A0A6G0WG21_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_016016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000239">
        <property type="protein sequence ID" value="KAF0725540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WG21"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007805"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0725540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="426" mass="48199" checksum="FBC4206AD4BC5F51" modified="2020-08-12" version="1">MTLPFEVPRTDAIDYIVRMPGATFFGTGLRAFTIDFLAANETSRDQMQPWQKCQLDLILGSNVGDMCIWLRKTKENVYAVWNAADILDTPATSWAKFVDRGLLTCYVLYVLWTRYYRHYRTLLSNLQQIGLSPNDPFVSVAMVVDMLSSVSYIGIALVQVTQFQDLLLYTSGCIYLSRGVWYAYLMMRILSFVVKKRGWEASFPPVDPGFLAVSAYMYCGPVVSILGTTSLIWALYFMWSIFLPQALQDQAIECITATAVLLIMISSLPIVFSRLTTKWRQRIRIRPSNVRCQSMSDYTFNDIKAYILLVLTSTNKPCILQEALCTNYIKRILDTGKFRSSAIDRAADCFVLCYTAEGHLGQRARLSLLSWLDTRDNDPQNMIVNCKADHSTAVGVINNEACALFGPISKNVKCVHLGSSNCQWIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WGS8</accession>
    <name>A0A6G0WGS8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_015367</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000218">
        <property type="protein sequence ID" value="KAF0726345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WGS8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012957"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000205">
        <property type="entry name" value="ABC transporter B family member 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000018">
        <property type="entry name" value="ATP-binding cassette subfamily B member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF27">
        <property type="entry name" value="ATP-DEPENDENT TRANSLOCASE ABCB1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="48"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="277"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="690"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="735"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="816"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="841"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="918"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="958"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="52"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="387"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="696"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1021"/>
            <end position="1257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0726345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1261" mass="136794" checksum="E0E3AB3684D29813" modified="2020-08-12" version="1">MAAPHDTYVAVETPKEPREEILHKEAPAPQRMVNFLQLLQFADKTDMILMTIGSLGAIVMGASQPIQVVFFGNIINAFNPQGGGQFEKDSFQHSINRVVYQFLVLATVMLIVGFFQIVGWSIAASRQAKRMRHAYASAILRQEIGWFDVNEPMQLATRVADTTLLVQEGMGRKVGDGINFLSMGITSLVLAFYYGWELTLVLFAFTPLLGLAAFCSSKAIAAAVQGDVESYAEAGGIAEESLSNIKTVHMFNAMSARAEKYMAALIRTEQSGVKKGFAVGFGTGMTYFIAMCTYAVGMYYGAVRVTNDQLSDNPCTGSRCYDGGRVITIFFSIVMGSMALGQAGPSMQAIMTARSAAYDIFELINRQSKIDASSDEGKTLDHVEGHIALESIRFAYPSRPNVEVAAGYSLSIPAGQKIALVGSSGCGKSTIVSLLERFYDPLEGRVTLDGHDLKDFNVKWLRDQIGLVGQEPCLFSDTIAENIRHGKPDATDEEVYEAAKQANAYDFVMGFSHGFDTAVGDRGAQLSGGQKQRIAIARAIIKNPAVLLLDEATSALDTESEHVVQASLDRLLAARQRTTIIIAHRLSTIRDADRIVVLSHGNVIEDGNHESLLKIENGHYKALVGAQMRSSDDDKDAPAKVAIARKISCAIASEEELIEESKVSTEVSADEGGSKNVPTSRIWRLSSPEWWHLVCGSIGTLFHGAMFPLWGVLLTKCTVVFFSLESGSHAMRHEALKWSMGFVIMGVVVLVAVTAQNHQFAVVCERLTARIRGLCFRSMLHQDIAWFDDHKNSAGALTTRLASDSAAVRTMTAETLNAILLNIATLGVALGIAFYNSWRMTLAFLGALPFIAAAQMLQLQMATAQTNKSVNDGDIKAGARLSEAINAIRTVASFNLEKTTNDVYLSNLQASSVTDRKIGFVGGVAYSVAQSSMIYAIAPVFYYGGWLMLHKLVDFQSMFMVLNPLLFCSFGVGLAAQGLGDVAKAKKAIKSIFSIIDRQPPIDCTSDAGIQLEHVKGELELRGLDFVYPSRPDSKIYSNYNLKIKSGQTVALVGGSGSGKSTAINLIERFYDPTAGAIFLDGQDLRSLNVQSLRNHISIVSQEPVLFVGTIGENIATGKPGATQEEIEDAAKKANAHDFIMQFPDGYNTSVGDRGVQVSGGQKQRIAIARAIIRDPEILLLDEATSALDTESERIVQASLDTLLQLKRRTTIIVAHRLSTIRNADVIAVTDGGRIAELGTHDELIAIPNGIYANLVARQMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WI68</accession>
    <name>A0A6G0WI68_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_015021</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000205">
        <property type="protein sequence ID" value="KAF0726879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WI68"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0726879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="78" mass="8667" checksum="8C0B6AAB41EF2295" modified="2020-08-12" version="1">MGLVIMPATCEVSGFVLCSARVLRCKGSKFHPKAMFLHIKKPSILCSRVHAERHTQVIHVIQWQVVSTEAYHGILALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WIZ9</accession>
    <name>A0A6G0WIZ9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_014735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000200">
        <property type="protein sequence ID" value="KAF0727206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WIZ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000119"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0727206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="264" mass="28289" checksum="05F751D30F7185F5" modified="2020-08-12" version="1">MFTAPSREIQRHIRPWTPGTFDSVNESFLSVGWCRPRTCRWILRGFVLFSNFPSTATMQITRAALVALAATAATVQGNNATDACWNKVTAVIDPAFSSDAIKNCAKDIQTAAPSWWAVIAENTKQVFNSTVSFFSSGDWNAPTLKAFNDSKVCQQWYTGVSSAIQQINPPCSFAVSNETQILTSKWNYTLTEFLDLYKKWNVSDLSLVDNATKAPGANNSTNPSSSPSAAPTTTAAPTTTAAKSSASVVAVGLTTVVALAVAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJ27</accession>
    <name>A0A6G0WJ27_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helicase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_014760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000200">
        <property type="protein sequence ID" value="KAF0727232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJ27"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000144"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005114">
        <property type="entry name" value="Helicase_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37066">
        <property type="entry name" value="HELICASE-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37066:SF1">
        <property type="entry name" value="LNS2_PITP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03457">
        <property type="entry name" value="HA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="97"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="173"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="253"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="2">
        <location>
            <begin position="331"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0727232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="558" mass="64066" checksum="7EB8863DEF4BB43A" modified="2020-08-12" version="1">MPTKRKQGDSMASILNGKLHKCTDFVEAATIFSTLHKSSVTNLPKHFVVPIDAAYPARLHGMHLNTAQVRAYYKHGNLHPDAIAALQAIHFVFDVNEHKWQVKLAAFQTYKALYGDMKIQQDFVVPTDDPQWPLETWGMRLGLVVRSLRQKTHMPASRMRELEELGFVWNILEQSWEIKLQALQTYKAICGNLLVPYSFKTPPESDGVWPEATCNLKLGHAVHNLRQNVGDMPAARRDLLNSIGFVWDCMELGWDTKVKALTTYKSLYGDIAVPYGFRIPRNDPLWPPETWDLRLGPAVHNIRQSGPEALAVDRRNQLDRLGFVWNVVEPSWDIKYAALQTFHRLFGHLDVPATFEIPKMDDQWPSHLWGMKLGAVVVALRHQRRQLDEECHARLDRLGFLWHASAESSPIVHSSNSPIENQDQWSLLLTALNVFRYLYGPSAVLHPDFVVPTMDPEWPAQTWDLQLGLWVDNSQSGRDKVPHDIQRQLEWLGFGVDEYNNKKRQVHPDGWPARQDRRTYSPDSTSSTSSTQDARRHIGGLPRLPELDRHAYQDRYDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJR7</accession>
    <name>A0A6G0WJR7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_014492</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000194">
        <property type="protein sequence ID" value="KAF0727470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJR7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021654"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043205">
        <property type="entry name" value="CYB561/CYBRD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10106">
        <property type="entry name" value="CYTOCHROME B561-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10106:SF0">
        <property type="entry name" value="LD36721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="12">
        <location>
            <begin position="1"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0727470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="236" mass="25628" checksum="68F5B07AEF396FA6" modified="2020-08-12" version="1">MGSLMTAYTVEADGTIIGRSMAGFSWSNKNDLVFNWHPTLMVFGFIFCSSQAILVFVSKPFEHYSNKLVHVACHSLSILSVAVGTIAIFRYHNEHGFSNLHSVHSWVGLTTLIVFALQYVFGFVVYFKPGAAILFRKASMPYHIGFGLGILALIAMTCVSGILEQLSFNASCDLTGTLNGQRVESFMALDCVVGSVVALLIALLSIALVVVVWVSKHRVDDVAAPDAKVHLLKANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WKC8</accession>
    <name>A0A6G0WKC8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_014313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000191">
        <property type="protein sequence ID" value="KAF0727688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WKC8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009163"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0727688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="193" mass="21921" checksum="BC9E922BE43CE2CC" modified="2020-08-12" version="1">MIGRRTIATASNYVKRLVEDANKHPTDSVRQLRVLQMLGKIHPSLVAQRVEEMPFAMSQEAHKEYMKALVRTGRIDAIDLKIMLARMQSTGMPTMTPQLYRARRASPLVDESGYRAWAAFATMAWGSIVGLSLYTFWNEEGWKEEHPMTAGFMRGLELQIDRANVAKPDKSKKKKASDKHVTPYENVSDIPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WKI3</accession>
    <name>A0A6G0WKI3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_014269</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000189">
        <property type="protein sequence ID" value="KAF0727753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WKI3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019822"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000251">
        <property type="entry name" value="ABC transporter B family member 19"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000018">
        <property type="entry name" value="ATP-binding cassette subfamily B member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF27">
        <property type="entry name" value="ATP-DEPENDENT TRANSLOCASE ABCB1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="276"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="689"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="741"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="816"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="839"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="916"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="951"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="40"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="385"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="693"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1015"/>
            <end position="1253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0727753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1258" mass="134917" checksum="94CD150B0FF39741" modified="2020-08-12" version="1">MTSSGKQKVYPEGSQQPQKRLVPLAKLFTYADATDRMLMVVGAVCAAGAGLSQPLQILLFGDVLNAFNPPTISTSVQVTPEMQQMMKDQMSDNISSVSLKFVYVGLGVIVCGFGQVACWSITASRQGKRIKQEYIRAILRQEIGWFDVNNPMQLATKVADTTLIIQDGLGRKIGDGINFISMGLGGITIGLVKGWKLALALLGFTPLIALAAFIMIRSLTVAVQASVASYGAAGGVAEESLSNIRTVQTFNSMAAFVSKYKAALVATEKAGIKKGLAVGMGTGAMFGMVIMTYAFGMWYGAVLVSDDQLTTPKCTSSCYDGGKVLTVFSTIIMSAMAMGQAGPPLQAVFSARAAAVIVFDLIERASQVDATSTQGKTLESVQGEITLEHIGFHYPARPDVQVCKGYSLHIKAGEKVALVGPSGSGKSTIVSFLERYYDPLEGVVRLDGHDLKTLNVKWLRAQIGLVGQEPSLFSCSIADNIRYGKPGATLAEVHEAARQANAYDFIMAFPHGFDTDVGERGAQLSGGQKQRIAIARAIIKNPAVLLLDEATSALDTESERIVQESLDDLLATRKRTTIIIAHRLSTIRDADRIVVLSQGRVVEEGSHDELMAQVDSHYKKLVEAQNRPAPASPTKVQTFGDASSKALQTSKSLALIPAAASPSGNDENAAHVVKPVPMSRLWKMSAPEAGYMVVGSLGAMVNGAVFPVWGVLLTNVTVLFFRTDLDADGMKSEAIKWSGGFIGLSLAFAVAVSVQNYGFAVASERLTRRLRELGYSAMVHQDIGWFDLQSSGALTTMLATDTAIIQSMTSETLNRGFVNLSTLGVAFGIGFYYSWRMTLAMLGVFPFIGAASAIQVKMMMGQGKLLNDGDVKAGALLSEAINSIRTVASFTLETLLHQQYEGHLSLSASKDVMTGLAGGAGFGVSQGALFFTIAFLFWFGGWLITHDYVDFKNMFMVLMSIMFSSFGVGLAAQNISESGKTKQAAARLFDTIDRQPPIDCSTTDGATLPQVRGDIEFCQLKFAYPNRPHALIYNGYSLKIPSGATCALVGASGCGKSTAIGLLERFYDPREGHVLLDGVDIRTLNLQWLRQHISLVGQEPVLFAGTIADNIAGGKVGATLDEVEEAAKKANAHDFILQFPGSYNTQVGDRGIQVSGGQKQRIAIARAILRDPEVLLLDEATSALDNESERIVQASLDALLALKRRTTIIVAHRLSTICNADIIAVTADGKIVEQGTHDNLMEIPNGRYVNLVQRQVNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WLT6</accession>
    <name>A0A6G0WLT6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_013893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000180">
        <property type="protein sequence ID" value="KAF0728242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WLT6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021176"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0728242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="237" mass="26699" checksum="6DA181A31718CAA0" modified="2020-08-12" version="1">MPKLTISLHVVISCLYIVAFASALRSYKRRHVRVVAVHPTTAAAAAARSSESRWNDVFIAGMNLLQIGSQSYQAFVMFNGLTRLGAILSYALLVVVYCFLSPVTLFIHNPRVKTTLVNVEDAVFRVGRWTHCQYILLDPSMANDNAWATEALLTTRMLVPTSIFDLMAKLTMYITTMASLRRATLDLCDGCRVDPSKFASKPPRRQLLKINAFLCGAWGVVLSVYREWLLLLRYEFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WMA6</accession>
    <name>A0A6G0WMA6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_013712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000177">
        <property type="protein sequence ID" value="KAF0728472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WMA6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014788"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0728472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="118" mass="13355" checksum="26892900A5E3349C" modified="2020-08-12" version="1">MTRSLVFAYQECDFRATLPPPSIFLLDKPPENLDQRKLAAEVVLREGIDLTTEEMEQQLAIIPDVPREVEPFDPEQLDVGETGLADDEKEKMKRVLRKFKQYFIKSGNGLPPPAKGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WMC1</accession>
    <name>A0A6G0WMC1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_013807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000178">
        <property type="protein sequence ID" value="KAF0728444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WMC1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014885"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027968">
        <property type="entry name" value="JHY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15261">
        <property type="entry name" value="JHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0728444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="251" mass="29020" checksum="9743F15846CAB7E2" modified="2020-08-12" version="1">MHGTLRRADGTEEVRSGPLRKKPQPTPLIHDNNRDNNHDFRQEELTPKREPVVVHESPRKPPHVSPQKTKPVKASTIDSPPVNRNELKAATEGDQLAFSKKARPVHYEPCTLTEYRQEKQDKYYELGKLKPDLNATELVEKRANQERIKEFSKNLRQINQTLPKKQKETVVEKEKAPSNREKALAFAKKKVPKPKVVTRKAVSPTKENARTSKRDQPEEPRDQELEVQSELHQLQLKHRAARAQLEALMRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WN51</accession>
    <name>A0A6G0WN51_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_013508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000173">
        <property type="protein sequence ID" value="KAF0728765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WN51"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021015"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0728765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="402" mass="44712" checksum="A5C999EA34E2F186" modified="2020-08-12" version="1">MFRTLATPTAALSYGAIVALYCFLSPLIVFVRNARTKATLVNLTNAAMSFALSYGHPLMTVALPVFQYIFVDGNLVNDYVWSAKVLLLARQLVPSNMLDFLCKAGVQIGAFVSLRVAALGLDRASDSPNEFIFTRQRRLLRLNLITNLTRGAVLIVLMHRSVWYRAACPHYCFLETRPLLDLSCQCAYADINCVNMSMANPESALNSSAIGTHLLYLAIRRCDMPQGIDPLALAPFENLGRIMIFFTNMKAWEPPLPPSTFYVLVRFSQLRTVPNALRKQLPLSLSTILLEPCPLEDIPDGVIQAWANIQTLTLVNVSLNEVPRGLSNLTSLEHLNLRMNNITVLPSWLSRPSSCLPLIFVRLAWNRITEIPWDLARRGAEVDMSGNPFAVAAGLKIPQPQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WNF5</accession>
    <name>A0A6G0WNF5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_013421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000172">
        <property type="protein sequence ID" value="KAF0728852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WNF5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001248"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051266">
        <property type="entry name" value="CLCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579">
        <property type="entry name" value="CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579:SF43">
        <property type="entry name" value="ZINC FINGER (C3HC4-TYPE RING FINGER) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00453">
        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="38"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0728852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="480" mass="52068" checksum="CAC6F96B476748EE" modified="2020-08-12" version="1">MSSAAERYEIAAKEAISTFVNCNLIAPSVQEGERKPIDLVVVLDRSGSMAGPKLALCKKTMDFLAQQLTPNDRVGLVSYDTHVRTDLSLTNMTDDGKQQLSQSVKAISAGSMTNLSGGLLAGLDAVQQPQCMDNGEPNTVKSVLLLTDGQANEGVTKAHDLVHLVKCMLDSQVSIHTFGYGSDHDAALLGQIADIGRGSYYFVQNVDGIALAFANCLGGLLSVVAQNIKLECIASPGVLIQSVKTKRSVTTVTNLAHYEVDMGDMFADESRDLLLEIQLTPQHPQIIMELVEFRLRYANIVTSSMDKASSTATVNRPVVVTNNELNEHVVVQKQRVLAAEAIETAQAHASRGNFAEGRNVLTSIKSRLETDMENMPSTTSTVSTLISGLSECTTSIASETEYRSHGHGRMQQRMQQAWTQRNNDTQVDRESLDKLVDAIRSAPPRDPNSAHPEPAPVQSRVGNAIQARMMQRAFNLSSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WPJ8</accession>
    <name>A0A6G0WPJ8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4833 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_013056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000166">
        <property type="protein sequence ID" value="KAF0729310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WPJ8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018385"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032269">
        <property type="entry name" value="DUF4833"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16117">
        <property type="entry name" value="DUF4833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4833" evidence="1">
        <location>
            <begin position="25"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0729310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="165" mass="18077" checksum="7762430DDA24F413" modified="2020-08-12" version="1">MADYAKVENDPVEHVRSSHEPNVVFCIHRNKNKNVVSYSAKIVDGALDSKDPLNVEWIMFENNPIGREGLNMIERNTAYGTNVTPWEGKAGSYKVVLASLPDKTIELHLVDGKPVATAEINGVAGCTLTRVFVTSTTSWGMPKVQHIEMFGTDPSGAPVVEKKIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WPW1</accession>
    <name>A0A6G0WPW1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_012932</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000164">
        <property type="protein sequence ID" value="KAF0729431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WPW1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008911"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF5">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="47"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0729431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="262" mass="29487" checksum="8CED8F70774DC7E4" modified="2020-08-12" version="1">MEVPEKHHDLDDALESQPYSSISTTTLPNGLRVEYALHGNDGAPEKVVLIMGLAGEKEVWTAFIATFFRQKDALTRFQILTFDNRGVGGTGAPSGRYKTSEMAQDTLMLLDHLGWTKVHLAGVSMGGMISQEIAFVAPERVQSLALIVTSPGFLEGPWPSWVQITGYLKTLSNFLATTLHERTMNMLDVLYPPDYMEDSEVSSALYKIHFERLKLSRTRRNGLMGQYGAVLTHRMDTERQRFQFSLWVEGKIVYSLCPIRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WQ01</accession>
    <name>A0A6G0WQ01_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_012960</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TMEM104 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000164">
        <property type="protein sequence ID" value="KAF0729462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WQ01"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002141"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16189:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16189">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 104-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="390"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="414"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="459"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="12"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="136"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0729462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="490" mass="53106" checksum="82C79A67D5D95344" modified="2020-08-12" version="1">MAGESNHIGSYTPTTGFVFLFNLIVGTGALTIPHAFAQVGILYGTAALFLLSVVSYISGTYVIEAIAGVNALHSLSKTSAVTNKRAEGMTENITSVEEGSSEAVPFLVHTEDTEQADEEYVSGLHFDLSKKLEMAAIAHELFSARGLMAFYACVIAYLYGDLAIYAVAIPKSLREVICPRPSSLLAESVWDCPGVHMNSAVLYRVLVALFGCMLGPFAMGHMQKTAFIQIATTVMRQLSFALMIILACVGIAQGQGRSVSDVVAHENISFLPNFFGICIYSFMCHHSLPGIIAPVSKKRSVGFIFAAAFIAVFVLYNVLSSSATFRYQPGEIQDVYTLNFVKYPNAFIAYFLSLFPVFTLSTSFPIIAITLRENLRTLFHANTSRNVSDLTLFGLLAIAPPLVVALCTEDVGMLVGITGAYAGLGIQWIIPACFVYCLRQRLVVVQGQLKLQGTPRNPYASSFSGFGWLAFLAVLSGASLILITYTRVFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WQ76</accession>
    <name>A0A6G0WQ76_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex component Sec8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_012795</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SEC8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000163">
        <property type="protein sequence ID" value="KAF0729527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WQ76"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016184"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090522">
        <property type="term" value="P:vesicle tethering involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039682">
        <property type="entry name" value="Sec8/EXOC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019515">
        <property type="entry name" value="VPS54_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14146">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14146:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10475">
        <property type="entry name" value="Vps54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="2 4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 54 N-terminal" evidence="5">
        <location>
            <begin position="5"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0729527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="880" mass="99382" checksum="CB7C2DE388F406FD" modified="2020-08-12" version="1">MKATEEIDRIFFDKKFSAAKYMLRFIVGATEDVRKEQLETISKYRALADKEIAGVVDANYTNFNASLKKFNTISNQLQDARAGLVEVSKRSMEGKAILTGKTKNLNDLLLLKYESKKVVQVVDDIDFIDKAPSKIRSALEQKNCSLAVDIYLRAFELVLSEKLAVFQAISSMRNSLMECKQIIEDHLVRNLESILFLKDVFGSFSKGLTQTVSTFQALLEADDVYNTDVHITSFSAENPLQEIVQAVKRLSREVDVAGTLKNTRAVQLKTVLGQIASLCKGKAFYEESTFGHHAASTNFQTYVQLLLQVMKKILQRHYVMVQYFNHTSCTMPDVVQKTFRLIHTDLNEFFGETKASESPSINNPTSEVGAGLFRFAQLHKDSSLQFNRNITDDDQVCPPSPFHLPIVHNDITTFSKSVEKICSASFANDIFNVYLTRQWIPRLKAEAENFLARPAALLKRRFELPMPLDTNFNTPDVHVLLHIVDVLFAIMQLIPAYGNDVASVVEFVVLRYVEECSAIVRKICEGTLNQLETGVAATELMRSFQDYSVYVAAKGNVPYQPLAKVLPSETVDAGPDSQSASSPPAHTYGFSYSLPTPIITTSTTAPEQPILNSQKEQLQLKEWDFETKFKDPAFWASPHVSKGLLFDQGKLAMLAYLNMACDAVSLHVEECMRSLLNIFGGSLEASNFTVALVIFVGLADECLFFLRRELRLHAFYYLTQVAQSPLDLPPDQTTFAPHDCIVAWNAHLMQLKLHLNATKMAFLLDGLDRLEATILMHILQHVSKISVGGVKQMHMNVCALQQNLTALFYGFPSIPRDFYRFERTKRYYHLLTLSETELELYLMENRRAFPTECLRAIWRVDVPTRALSKSSVNKLDSLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WR69</accession>
    <name>A0A6G0WR69_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_012585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000159">
        <property type="protein sequence ID" value="KAF0729946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WR69"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009826"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0729946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="130" mass="14307" checksum="36A0B309B56D112D" modified="2020-08-12" version="1">MIQVVAHIEISIRSATVDDMVVDIAVEYALSHPFLILSALFFAAFISSGAVRRALFVGTTYVTLSLWYQYRQLTKPKRPPSSSSSSTTTPPTSSRKSSEDTSERSVTTDDGSSSEAAFKPKRTKPRNWAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WSG5</accession>
    <name>A0A6G0WSG5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_012360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000155">
        <property type="protein sequence ID" value="KAF0730367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012510"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050723">
        <property type="entry name" value="CFA/CMAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010775">
        <property type="entry name" value="DUF1365"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43667">
        <property type="entry name" value="CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43667:SF2">
        <property type="entry name" value="FATTY ACID C-METHYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02353">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07103">
        <property type="entry name" value="DUF1365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="659"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="696"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="723"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="863"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="2">
        <location>
            <begin position="21"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0730367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1290" mass="143726" checksum="2EA8867F4393C4C2" modified="2020-08-12" version="1">MVDPSDVPPSKHVVIVGSGVTGLVAARTLSKYSDCRVTLVEAGDHVGGHAYTIDGPADERIDIGFMVMNNLTYPNLIALFREIGAEVEPSDMSFSVVDPSFSWSFQGSWAWTIANVFRPRLWAFIKAHGEFARRGLEFLQDETPRATTTREFAKGLSPLFVDKWLVPFVSAVWSTSHDGALDFPVQPLLKFMHHHMFLTLETVAWKTPANRSETYVKKLLDMCPKLVVRTSIKAERIDTARKRLILQGGEELQYDALILACSAPQAAALQPPASTLPWIKQFSTQASRIVCHTDSDQMPRLKEDWSSWNVAGTPSEGPQVTYWISHLQNLAQRNVFLTLNPTTEPKNVFFETNLAHPVMNASAYKGQLEESQFQGHDDVYFVGAWLRNGFHEDGAVSGLIAARRTLGREDIPVEFPTLKGLLATPVVGSSHHARYLPKERAYSIDYDMHLFHFDTRSPPPNFNRLDHFGDPKIPLDTCVRRELCTRLGYWPLGKIEAVANLRSFGLSFNPMTPYFAHDEAGVLQALLVEVHNTPWNERTLYAMRVRPGDVLEPAIQPKAMHVSPFNAPPSERIDEYEFQLRGKSSLLVTLRERDTKATIMTASWKVDYTKTHNVQTGSWRTVAQIYVQAMRIFASGLAMYAYNAQPTRTWTSPLLVFPILWFAGVAALLATNLSVASACAFATLGPLLALHHRYHGVNLPITFVAAISAIVCSLILVSSTDNVTWHAGATALLAFVASIFTSKEQFTSTRLVSYANIAVAATGSHLPLWAHEGASYLSLLHLWTSRQSTSNSTGFYASLLQAIVFARLSWLSLASGDLLATCHALLATHVVHGLLEPTSNCEFYAHASIVGIAAFLHPWEPVLFSWTVLTALILLQALLSVVWAFLSRSSAFLAWRDRALTQFMQAAMSAATDGRVLVVQPADADEVVKGRPAILVIRQPMEFFEALVANGELGLGESFVRNEWTLGPDTTLVRLLETLAAANLQDNWLILALPYLSPSFYFRRAAFMFRFGALDRTQSANSIAEHYDDGNALFKAFLGDDMVYTSASWDGIPPETPLRDAQRHKVQRILDLTQARPGDKMLDIGSGWGYLVHAAHKAGIDATGLCNCRSMVAAARSRYGDKLFSLQDYRDIPATHDHAAVTAVEMIEAVPAAHYGDFAAACSRALKPGGRVVMQVIHAYAFNNPVARSRTPVPLGTFVTTHIFPGQQVPNLEFLHEAFMEHKFKRVFTETRSHDYADTLKLWAENLDAYRHALPPTVYRKYKYYLNWCEVGFRIEKIHLSRVVFEKQTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WSM7</accession>
    <name>A0A6G0WSM7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Complex 1 LYR protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_011922</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000153">
        <property type="protein sequence ID" value="KAF0730498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WSM7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015866"/>
    <dbReference type="OrthoDB" id="529194at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20267">
        <property type="entry name" value="Complex1_LYR_LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045298">
        <property type="entry name" value="Complex1_LYR_LYRM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050435">
        <property type="entry name" value="MZM1/LYRM7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46749">
        <property type="entry name" value="COMPLEX III ASSEMBLY FACTOR LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46749:SF1">
        <property type="entry name" value="COMPLEX III ASSEMBLY FACTOR LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="5">
        <location>
            <begin position="9"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="91"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0730498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="126" mass="13733" checksum="CBB8E02268C0EA05" modified="2020-08-12" version="1">MASNSVRAQVLGGYRRLIRASRQTFGADKRAVVEAHKAVRAAFLENRDVKDVSALQGLIKGIDEAESMLLYNIVQGQANEQGTYQVTLTDPQKSHMRKDEELTEITPDTGKTPVVTKSCPDGGCPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WT90</accession>
    <name>A0A6G0WT90_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_012093</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="VJMJ01000153">
        <property type="protein sequence ID" value="KAF0730674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WT90"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003269"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF147">
        <property type="entry name" value="PALMITOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="8">
        <location>
            <begin position="72"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0730674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="231" mass="26591" checksum="3A3CF58CF77992F5" modified="2020-08-12" version="1">MVNICVWIASGLMALKLICVLTIVNIPPLHLVVYFLLTTFMLVSYAGTAFILPSFPVSVLEDEGDNNNNDEQEARYCEKCDRIKPDAYHHCSVCSRCVSHMDHHCPWTGNCVGLRTKKLFLLFLFYTSLSCLWFAYCVTFQQLGPTGNFLWFTVVLATLIGWLLFGYFWFHIYLLAVGRTTLDFMAHRPGNSDGFRRNLETYFGLNWWAYWIPVVPASLWQERMPLVDSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WV88</accession>
    <name>A0A6G0WV88_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_011328</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000143">
        <property type="protein sequence ID" value="KAF0731427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WV88"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003015"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0731427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="27586" checksum="CD7BD52557C1F7D2" modified="2020-08-12" version="1">MQAIRNDQRTPKLHDIILSNIAEFIADPKVFFAFLQAVVPANLHEPYKSIWELQELEINHSDLWPLLRITDKLSFSQLEKLQDCISHYPVVRVEGMGNVEWQQQHLPPTTEVHWTLPAKLPPSQWNELNSFQTSRVRMKLSRYDNDDVLVAVLSDFPHLKALDIRLFEFEGIESILSFAADNTQLTELELSSRFEYDDYLACLTETMVENIIKWFRRQPVRVFRVHHWGIDADDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WWK9</accession>
    <name>A0A6G0WWK9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_010891</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000138">
        <property type="protein sequence ID" value="KAF0731939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018452"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF73">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="420"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="542"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="650"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="699"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1048"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1101"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="7">
        <location>
            <begin position="130"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="6">
        <location>
            <begin position="1240"/>
            <end position="1361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0731939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1454" mass="166246" checksum="98A407041453B120" modified="2020-08-12" version="1">MSTGLVTPIPEDLVTATDIPPSASIDKKSLTSLLPGLQSQTVEPSLKTVRDHKHDEMRAKIRAHVGQSLRALGEQKRRNSRRICGLTRADIFQWIRAMLFCSDADSLDDAADDSDSKISSTKKFLRGVEDLSNLTGGELSQLARLAEMRSFRRDDVIVANEEQADGLYIVMSGKAARAFMVQGQVDETLPIESIEYQEAFGMNIPALIRDDSRIESSVTAVSEHVECIWLPHLVVRMLNLEPRMEYEFVLILKNPSNGKDSDLKQQESILTNILQAGIHVTVMANTRNTCDKIILLLNAPLWLLAREDKLMKMERIVEYHSEEDAKCLGDEYSSNADSMTAADRISAFASILTRPTTDHPPGVGLRGIENNQDAMVHDIFPLHDPNVNDFITSSWFKEALSTSTRRLFLLRTKDHFGLQIAFYMAFVRLYCSALSTPCVVGILLWIIWRQAHYWSYMQALGIFGLLVAFVWAPSVLKRWKRYQHALLVEWDLIQAKEVEYPNHQFKNYVVETINVASEGDTPDYVDIKTYDRRRRYPKYISFGIFAVICCLLLFVFVGLYCQWYIIAVMTPMCDDPRCPKFLDANNCITQCELLIQQGKTYNFLREIRSSVRGCTGYCDLSTFDPSYYSCDTALVGCFATERGIVGTARWTYVLVQGIALGLTLDIIFLAIFEQIASVFNKWENYATTQENERRFVEKIFVFNWVGYFYWFFLLCFLYTPYGENVQAYIRENIDTKPWLTANGKLKFSRYWVSGLVAMDSAFVTPLIVTQALNLLINTFVPYLLRRAVIRARDAYLVKKDELSLKLKNGLNKPAQNVVDLNQNASKESAIRLGELQLQTSSKTEKDAKEMKLHLVATSGQNDFDLTELEKEELALHLAEKRPIRAADLESTAVYLFGNLSRHHNQMSRICSNIRREELDEYQVTSYDWIDRVTQDIAHNKKHENIWEDSLHKTKNQPSFRLRLIKDWHCRKYIYNADRIIEESSMSVYSPQGDLLHMAIQFSYVTMFSVIWPFCALCAYCNNAVATRFDTIKMVIDCKRAVPRRVVGIGPWFGAFMLETLVATMVVPAIFVYVTGQMDAFSSTCTISETNYGPVTNCYSPIYRLIAFCLLENIGIGICFFVYLRKKDISRETSIKMQEHSRRVKYSVRKSVRTIGEHILVDVNEGEWRQGTVAWVQNGRVKVNFHTNEGFGEVSHSIEHEAWLDKERYVLEAPIPVRIFDMGMPVLLASAKKGIWLEGNIVGLDLVNRSGKELAYSPNEMHLSILEGRNLKSYMLRNVLDPYCVVTCGTFKHMTTIKRHTLNPLWNEYLVFTMTKKDMNASNGKLRLSVYNHDALSLGECIGEAEIDMSDHINGQRTKLLVPLLLKKNGLNVELLGNAVHKLALGDDCFEPQLLIEIQWIDSRFPAQVQVKVKQDGEEVMPRVLTRKQCETRLCYGFHSHEIKEGRIYDSNIAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WXB5</accession>
    <name>A0A6G0WXB5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Kazal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_010785</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000137">
        <property type="protein sequence ID" value="KAF0732134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WXB5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021220"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050653">
        <property type="entry name" value="Prot_Inhib_GrowthFact_Antg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10913:SF45">
        <property type="entry name" value="FOLLISTATIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10913">
        <property type="entry name" value="FOLLISTATIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00050">
        <property type="entry name" value="Kazal_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026261770" description="Kazal-like domain-containing protein" evidence="4">
        <location>
            <begin position="19"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="5">
        <location>
            <begin position="20"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="5">
        <location>
            <begin position="72"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0732134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="131" mass="13992" checksum="B8691DBEF94B32BB" modified="2020-08-12" version="1">MKAVAVMTMGVATLLALADTTDKDFCAPNVACSRVYSPICGSDGTTYNNECLFKIAQCTESTLAKVDDAPCPRVEEVCVASCPDIFKPVCGSDGLTYENECTLKRDACVKKTGVTLDHIGDCDGEWPPKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WXF5</accession>
    <name>A0A6G0WXF5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_010829</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000137">
        <property type="protein sequence ID" value="KAF0732180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002025"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050576">
        <property type="entry name" value="Cilia_flagella_integrity"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973:SF9">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="9">
        <location>
            <begin position="1425"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="460"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="901"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1016"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1364"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1442"/>
            <end position="1488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1503"/>
            <end position="1533"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="106"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="474"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="487"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="511"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="540"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="570"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="934"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1020"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1377"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1460"/>
            <end position="1488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1516"/>
            <end position="1533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0732180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1533" mass="169454" checksum="2FCDBAB637D24285" modified="2020-08-12" version="1">MAHWQGLKPQSEVVQRGIAAQIRQRDDNSGKTLLRREDRRFLNQVIHDSALEHDPQFDERLKYIAEYSGSNVHSTHGERDGLSDALSTGLMVFGALATLGAGAYSAYQERQRRNEMERQRKEMERLRKEREFHRQMQQLMFVAAAIFALIVFGLCWLDCNRFVGFKLHFFEGHPAAPHAGVHAMDISRISKLGKIFRKKKGLDLRPQSVYDLQKFRDLFLAASARHNCRVPPCIDKMIYKAISAQKNITSMDFHQEGIEDDAVLALMETLLEMPLVSTLDLRENAITDRGVRAILELMRHQLVLARGSAHATTKPLPEFTRFLTCVHLKGNNVSDSAMQQVRQYSSMLRVEDKRLEIQAVLNQIDYNDAGGVDEGEIRVALKLCSGGSEPAKKDVDYFADHLSSVTWHVTGDADASKILSNTRSSVETLLLAKYAKSPSKKDTAGMPPLDSLAHIRHAELVNPLAKPEQPPYRLGDEIMRDDEQSPRRNSSSPEKEPSSFSASSRDLRLPRTSNASMHESEASPTSRTQDADVSMIHPMPVEDPRPCFPLDDHLEENNHRGGEGVHRDDEPDAGDDEEQVDDAPDEHEDEEALEITTEHVIEEEEAAAVESLNASPIEMEEHFHADEQEIVDGDDASEVVAVEPPVDETIREFCLMDQVQLQQQSRTVVKLQHGRIRAGDALDRLFDSVYFDNVVALVLSNNQLQSMEPLRALRVLDLSRNQLTKLNATELVKVRHVEVLDLSYNGFTSICGIENLTKLRALSYEGNSIRCAKNLECLERLEILNLAHNAIHVPQSLRLLSMNKLLSHLNIDENPIVQAGTGRKVSAHIINIIPTLRSLGCIHLASLVVKEKTKKSTLPPPPEEPVRSSIFEFLDAAPPRPWVDQACEMLCIVCDHPEVSASPEAPKISRTLQKTKDEQRSKALPHHIARKTPPATPPPPPLPQPISKPTISFSDQQRKAVALSTPRVFKPPPKAPQMCHPPRISKPPPSSSASGSAKPTVAVVLTNKGFLQPTKASLHAHAEHKKERDKAKKKKKPANILYKRLKRREEQLRHVMATSPVKLAAAPAPAPSSDPPVLALPTWTPPSRETSPIKLGSLAITSTDTFLAQIRLNDFVTLVTEDHATASTALDVLVAMCEQPSDDGAKFTAYKANLESLHILDDVAVTCATQEALDMAQAQSNEPLPVLARLDELKRIKQTLKLVVDHVESTSAPLGSSSLLNVCLQVRNGPLGHLLSPCEERQETQQGTPTPVETTSSLDLLSPVNATTTTHLFDSTTDDPFGLTDTEPAAATSIDTAAVHLTTQSTDPPADAAPLDLALDAAFELEASLDNAEPASSPLGLDETPEAVHELVDPILTENEEVNETVDAPSPVLSNEDFPDDEHEEAEEMEEVHAEEPEQVELVDEVEEEAAEEEGSDAPLTWGDWEQGYDPSTNHHYWFNNATDESSWTPPEGWPHALDDGAEEEAEEQDEEEEDDAVEEDATEQVQELDVELSLEDRIALALGGGSAAPPPACSMDDDGDAVMFDDDAFPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WYP4</accession>
    <name>A0A6G0WYP4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CBM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_010324</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000130">
        <property type="protein sequence ID" value="KAF0732616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WYP4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003875"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026356252" description="CBM1 domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="4">
        <location>
            <begin position="298"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="187"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="187"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0732616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="336" mass="35333" checksum="6FEEE64E1CB7F6DB" modified="2020-08-12" version="1">MVASIPTILFALTSTALGHGYLNVPLPTFLPGAGDITAYCGTMDGPKVLPGDQYNTSPDANTAAFTKQFKASSYKTLKDFITANPGGCAACGNTDPNGTPMELPSDGNIYWHHGQEGFTPSHEGPCEVWCDNTRVYQNEDCARNIPNGTIPIDLPTCQKSNLLAVYWMALHSPTWQTYINCARIKGSAAPSPTSATPTVAPTTKPSSNPTTAPTTKPSSNPTTAPTTKPSSNPTTAPTTKPSSNPTTAPTTKPSSNPTSAPSKSPSPSTPTKRPVTPRPSSSSPYTPPPATPSPPSNGQVQGYYQCGGRNYNGPTQCASGFNCKNWSEWYSQCVPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WZB3</accession>
    <name>A0A6G0WZB3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_010188</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000128">
        <property type="protein sequence ID" value="KAF0732863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WZB3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019869"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="141"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0732863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="304" mass="34787" checksum="BC56ADC53609D945" modified="2020-08-12" version="1">MSKASFVQIVSIIEEHHVFTDQSTISQAPVYQQFLVFLTKLGRFGNGVSVGIIAHYFGLSEGLVSVYCNRIVIALLDIESRVVFWPDGHERRLIASRIEMEHVFEGCAGFVDGTLFPVYSRPSVHGEDYFCRKGFLWYGWNGLPGAVHDMRVWSNSVMRTHASKYFDRFEFLLVDSGYAMSDVILPSFKRLRGCRFVNENCIGLLKGRFQSLRGMRMDISNPKAAKLMVMFFRCAAVLHNLLLDMSDSEDEWDTELRACDESNATSDLDAVDSNQIEIGYNNPCERREYHADKFWMETLNANYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WZP7</accession>
    <name>A0A6G0WZP7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_009897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000126">
        <property type="protein sequence ID" value="KAF0733075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WZP7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011813"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008701">
        <property type="entry name" value="NPP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05630">
        <property type="entry name" value="NPP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0733075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="107" mass="11939" checksum="1F95EA3128DF197F" modified="2020-08-12" version="1">MHGSYSKHGGMVTAPENEIPNQDGHLKFVYHKDGANTRCFRFAKTDEVAENPVGTFVLPTVASWYSMKGDGLDNANLRNKLNTYDYGLASLPTKDRAFLSNLNKFKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X029</accession>
    <name>A0A6G0X029_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RanBP2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_009994</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000126">
        <property type="protein sequence ID" value="KAF0733177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X029"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012824"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="4">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0733177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="128" mass="14781" checksum="AA87065C5EE402A3" modified="2020-08-12" version="1">MESWYRKGLNLELLGQPYVTIGTTNLSWRNSATWRPPTTRRAPWSFSNSPPTNKMIQNMSLLTQKLRAFFTKNQPEAAATTSDATTKEWFADQWRCAECFQVNTSRGGECTKCNTHYDAYTYRCSLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X083</accession>
    <name>A0A6G0X083_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COP9 signalosome complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_010011</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000126">
        <property type="protein sequence ID" value="KAF0733194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X083"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012808"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055089">
        <property type="entry name" value="COP9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050756">
        <property type="entry name" value="CSN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758:SF1">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22788">
        <property type="entry name" value="COP9_hel_rpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="8">
        <location>
            <begin position="225"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0733194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="450" mass="49538" checksum="D67B78775ED5459C" modified="2020-08-12" version="1">MATSIAEFILQHCKNQSTSLENADLSKALASTSLEELDNTLECLNVDEYAAAIAYLLCAKGKRLPKLHIQDDDDDMDMRVDHLDAPDQSQHVAFLLQVSAFLSNLRLLPFENREATKLRDLVKIAVHVGIACNQTIHLVYPLREVILRWQASKFEAPSITHANKYALTSLHGYFALACLHAKCYHAALAILDQPVFEVATPSAVRSIHVLEYFYYGGMIYTGLKQFRDAAAFFSMALTTPAHVLSAVVVESYKKYILVSLLADGEVSPLPKSTPLVVSRNIESHVAPYLAFATAFKNLDLHQALDAANDIPSDVGLVKQCVEALKKKRVQQLTLTYTNVSLAKIAQEMGGSSVQAESCVLDMIEGGVVSAAIDKEKDMVSFTFASMDDSAHDDALLQATIEATIMYTTRLQEIDVALTKNPKYISRVKEKRGGKYVDTDESTWLAAQTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X0L7</accession>
    <name>A0A6G0X0L7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine/threonine protein phosphatase 2A regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_009666</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphatase 2A regulatory subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000122">
        <property type="protein sequence ID" value="KAF0733420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X0L7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001291"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000421">
        <property type="entry name" value="Serine/threonine protein phosphatase 2A regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002554">
        <property type="entry name" value="PP2A_B56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01603">
        <property type="entry name" value="B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028043">
        <property type="entry name" value="PP2A_B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR028043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0733420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="494" mass="56691" checksum="EC66A947714A0630" modified="2020-08-12" version="1">MSMNKMLQTVKRRLSNSSEGDSAAGTSTNSVGISSQASSREDGIENVARSDVSLPRRERRRSSLVRNQKVAALKDLPHLKDTNMQKREALFQQKLELCSVLFNFDDATSDKKGKDLKRQTLLELVDYVNNAGGQKIFTEALMPDIMAMVSANICRALPPQTEDFDPEEDEPVLEPSWPHLQVVYEFFLRFIVSGEVNAKVAKKYVDQKFCLNVIELFDSEDPRERDYLKTILHRIYGKFMSHRSFIRKAISNVFYRFVYETERHNGIGELLEILGSIINGFAMPLKREHLQFLVKALVPLHKPKCVSLYHQQLSYCITQYVEKDPETAIPIISGIVRFWPWACSSKQVLFLNELEEILELMGPDQLQQVHKDLFRVLSKCLGSQHFQVSERALFLWNNEHLVNNGCLSRQHASLILPVIYGPLYKNSLGHWNTTVEGLAQNVLKLYMDYDMALFDKCAKEYLAKEERLSDKVTAQADKWKKIELLAKARETAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X1Q2</accession>
    <name>A0A6G0X1Q2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_009392</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000119">
        <property type="protein sequence ID" value="KAF0733827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X1Q2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010145"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052981">
        <property type="entry name" value="Ingression_C2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47052">
        <property type="entry name" value="CONSERVED SERINE PROLINE-RICH PROTEIN (AFU_ORTHOLOGUE AFUA_2G01790)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47052:SF3">
        <property type="entry name" value="INGRESSION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="126"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="188"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="146"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0733827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="384" mass="41248" checksum="7E2D0DD2D1470DCD" modified="2020-08-12" version="1">MPELHLRAVSGRNLYDAQTFGKQDPFCIIQVGNQVQKTKVHDNGGRFPSWNQKFVFNVRDPQVDQITITIEDENVFDNGYIGTVRIPVNTFLHGQIVDQWFPVMRNKDHRGEINLRVQLMNVPGQTAGAPAGYQPAPQPGYPVAPPGQQQSYPSAAPAQTYSASPATAAPAYSTVSPAYSGASPAYPGSQSNQQLQQQQAQLQAQQAQLRQQQEKQNDLVRQQQQAQQAAIQQQQAQAQQQMAASQQQIQQQQHQLEQQRAQLAQQQASLNASRPVYVQPSPPVYAPPPPVVVQPHPTVVVAPPPPVYVGGPVVYERPVVYEPAVVYSHPDGGGVAMGAAAGLGVGVVGGALIGAALSDDGGDRGYYVSDDGGYDGGGDFAGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X3H9</accession>
    <name>A0A6G0X3H9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_008856</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000114">
        <property type="protein sequence ID" value="KAF0734396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X3H9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020267"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF444">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08284">
        <property type="entry name" value="RVP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrotransposon gag" evidence="3">
        <location>
            <begin position="53"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="613"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0734396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="718" mass="79792" checksum="501EC3D7593AD733" modified="2020-08-12" version="1">MNNEDTNVREGRVKLDVPKYSGAAAEILLVWEAGVKMAIEALDLQSGTKQVAFAISCLSGKAHTWVVSAYMRDPAAMNTMANFITLMKATYLPKDAQLRHLHQLMKATQGKLSISEFAQKMEYHWLSLPDKSLISEAAIANSFMHGLHQGPSRLELFRRVPKTMTEALAIALGEHYSQAAASHAGHVDTDASTSTGKLLDPVGAGLPTGRTDQHDPNTASSGSVDLAPGTLCRLGEHHQMLSYLLPVPGFSDPLRVLIDSGASENYARRATIARASDVPTSKARPNDTLRIRLADGRIVSDPRQTVVLDISIDDFSSKEEFFLMDLDDRWDLILGMEWLERHQHLIDWHLKTMVPPHPRSHVSNPAQSNELAVVSIDPPSTRTCDGTVDHPRDEQAIQACDTPSNEPEGLPAIAEEISDVHEEESIDEYYFRECAASRNKQDNPDKLSVDEFIRSACDLEELPTRADEIVALPEMSFRSFSRLLRAQERLSIAVICVEEDGTLHTTSTMDKDVLDDADKQARTTWESLKTSPYYDILMEYKDVFPDEVPAALPSDKGIHHEIDLVPGTKYCVTRQWPLPRDQVDFIDSFFAARKKAGHVRESNSPHSSPTFCVKKPNGGWRIVHAFNTLNQATIPAQTPIPRKDVIIDSMAGSTLFSTIDLRDGFYQILMRIQDIPKTAVSTPSGMLWEWLVMPQGRHIQPHGYGETSPVACVCTVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X5E3</accession>
    <name>A0A6G0X5E3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_008381</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000101">
        <property type="protein sequence ID" value="KAF0735171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X5E3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008559"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15959">
        <property type="entry name" value="SYNTAXIN-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15959:SF0">
        <property type="entry name" value="SYNTAXIN-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="213"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="165"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0735171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="303" mass="34656" checksum="E5B598A57EDAA1B6" modified="2020-08-12" version="1">MTAMDITNEFVKLAAGSSQRRKSRTTAVSDFMQSAIEILQSVQKITSIRNDKRKQYLDPLHFLPSKASSFTDLDREELEESLLDSYKVCDERLSELHELHDTKHPQLSKLQAEIILYLNERIKRGVASTKEDQQKRISRPFFLSKKLLPDGVDLDRVTLVVPQSKPSTKPIVSHQSTPSESVRVAEESRRNDDSIGLTDAESRQFMAENLQLHRHFHEEIDAARKVEQQVNAIQGMMSQFAQEIGQQTEKMENITKEATMARDNVGHGNQSLKKAADYGEGFGFMIFCFYFGASCLLLFFHYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X5L2</accession>
    <name>A0A6G0X5L2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_008167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000100">
        <property type="protein sequence ID" value="KAF0735251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X5L2"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0735251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="76" mass="8399" checksum="5594043509545E95" modified="2020-08-12" version="1">MVTKRQCGVTSMNRESTTGQHIDAKSGNPATKPNSIMLMSVTIDDILSKNVLRTNHGRPKHEQKQCPSIIAARDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X5Z5</accession>
    <name>A0A6G0X5Z5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_008078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000098">
        <property type="protein sequence ID" value="KAF0735386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X5Z5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014121"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="240"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="328"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="328"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="346"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0735386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="356" mass="39712" checksum="ADDDB713B7D7EE4C" modified="2020-08-12" version="1">MPELRDLLRPSVEALVAEDTSRPHEAAKEKPYLSSFAGVALEPKRTLNEAATSTLIAILRRHAMDLVLRGTFSATDNDVLVQSIGFHSGAYSGKSLDVSMVHALRLPLSTHDPLPVDKAQVECSILLGQSHIDVALSIYAGAPLPSTFWDSIQTWTPGCTFGGFTFPTAPLSRFAPRPGPSSINFLLQQDRSTTNIYAVDGMLFTYNAPSVTSYIVAAKLHQDEALSYRTLSKQQMQQWAVEKRKQGVALRRQGKREEALEAYTTAIDMDSTDPDTFVARAVLHLDMKRKDLAKDDIDTALRLDPAHSGALEVSNKLRPDPDRLRALLEADDRKVRKEKKKLEKKEKKKHKKRRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X637</accession>
    <name>A0A6G0X637_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acyl-coenzyme A oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ae201684_008199</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2,3-saturated acyl-CoA + O2 = a (2E)-enoyl-CoA + H2O2</text>
            <dbReference type="Rhea" id="RHEA:38959"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="ChEBI" id="CHEBI:65111"/>
            <dbReference type="EC" id="1.3.3.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the acyl-CoA oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000100">
        <property type="protein sequence ID" value="KAF0735284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X637"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003210"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003997">
        <property type="term" value="F:acyl-CoA oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033540">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA oxidase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000015">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000003">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055060">
        <property type="entry name" value="ACOX_C_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029320">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002655">
        <property type="entry name" value="Acyl-CoA_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="ELECTRON TRANSPORT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909:SF250">
        <property type="entry name" value="PEROXISOMAL ACYL-COENZYME A OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01756">
        <property type="entry name" value="ACOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22924">
        <property type="entry name" value="ACOX_C_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14749">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000168">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 13" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-coenzyme A oxidase N-terminal" evidence="15">
        <location>
            <begin position="24"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-alpha1" evidence="16">
        <location>
            <begin position="282"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-terminal" evidence="14">
        <location>
            <begin position="484"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="432"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF14749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF22924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF0735284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="659" mass="73648" checksum="7315059218C4C798" modified="2020-08-12" version="1">MSTTILDVERRKSPAGLSTELAETFYHGSRAKREQFRRLRALLEAHVLYDDGQKLLSEPIEEQRKRALRMSCLSEKLILTHKLNEEEADLLRNISYEFSGFESPILLHNAMFTKNIKSIFTPEQQASWGSSIESFKWLGCYAQTELGHGSNLRSLETTAMFLPDQDKFELHSPTLTSYKYWPGALASTANMAVVYARLLVHGKDYGVHSFLLQLRDFETHQTLPGITVGHIGRKIAFNNVDNGYLKLDRVLIPRTNMAMKFSTLSRDGVYSSVEGVKREISYFTMLQMRYNMMFMSGKCLSKAALIAVRYSAVRLQGLSATEPNKELQILDYQTQQHRLLPRVAESYAIMTTSHKYTAFCADATAMVDNGTEVDSIVLTMAHASSCALKIVASELCTNGIEVCRRACGGHGYLQSSGLPELLGYAAQFVTAEGENYVISQQTSRTLVKLLQGYRKGMALSTPDLQVLGAIDAPLPKWSASNIDYVAIFQRRFLALLKEFEATAKRYKSMDHAIQDNLIESHHLALSYGKYVLVHEFAAAVNALPASGVAKPHARNLFELFCVTQLQHDFGDFVSLAGLPSSTRSVLHKRLVDLLATLRPHAVALAEGFDHTDATLNSTLGRADGRVYEALMKSSLLYASDDIPAFTEYLQPLRQLHARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X7P1</accession>
    <name>A0A6G0X7P1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_007616</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000090">
        <property type="protein sequence ID" value="KAF0736028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X7P1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020108"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="33"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0736028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="451" mass="51293" checksum="C1CCAFE705757CD9" modified="2020-08-12" version="1">MDDAWDIATDLPFLIARDEELKAELASVFDLLAGEEDATDNTDSTDSTSTESTDESDGKSSPPPAASASRPAKRKPKVSNAPPGARNPYQFRQKQEILLLQSQVETLKQQLEEARQSSVKKDNMPKWERAARMELQAKLRALADNEQMKADIEQQNSFIAEMERFFRKKPRLTMETDIESEEWCAYKLAAKASLRFTAIHAIADRQYHRMETAFINADLVDVIGNLLRLRPVRLPNNKLLIELVNHVTLAAPYRNVAKSVWQTHRTPYVSETSQTTVEVLDPYIVYEQCTETKYKTTCHSNTISKYYQEDKRDVILWRTVLEDELSPHMLKGAVDDQWGWLELTPLPNRNHCRLTLLMQIMADTSESAPPQLKVDATVDSITATLQMMSCSVVPKHALPHSAPFGTVQRDEITDGLPPALLTFMERGRRMETLLRSAVDRAIADFNNFKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X987</accession>
    <name>A0A6G0X987_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipoyl-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_007069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000088">
        <property type="protein sequence ID" value="KAF0736619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X987"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018292"/>
    <dbReference type="OrthoDB" id="537444at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151:SF90">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="1">
        <location>
            <begin position="44"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0736619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="218" mass="24467" checksum="B667E8B2F9FFF3F0" modified="2020-08-12" version="1">MLLLRRTSLNLPAIARRWCHANSSKLPEHIKIRMIDVDFTQTVEGSKLNRWFAEEGKKIGPGTPFCEIETPELLFSLESEDEGYLAKIFVPEQADHIRPNQVLAALVPNEEDIAPFLAALAENPNEIEEYKPSSQAAATTPAEPTDGADLLRVLSQLNKEGAFPSEAVYKTLKSLARKNDEELLRVYKGSFQEDNTTSAFDKEFFVENCLDLVDEKTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XAB7</accession>
    <name>A0A6G0XAB7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription initiation factor TFIID subunit 9B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_007011</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000087">
        <property type="protein sequence ID" value="KAF0736855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XAB7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017801"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07979">
        <property type="entry name" value="HFD_TAF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003162">
        <property type="entry name" value="TFIID-31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051431">
        <property type="entry name" value="TFIID_subunit_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068">
        <property type="entry name" value="TAF9 RNA POLYMERASE II, TATA BOX-BINDING PROTEIN (TBP)-ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068:SF4">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02291">
        <property type="entry name" value="TFIID-31kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0736855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="24717" checksum="218AE967024710D5" modified="2020-08-12" version="1">MSEPKENAKEKTPKKQKVAGRSALNVTPGSLTDEDSVDDPAFSKEQQEPEDVVVLKAILDSMGVEKYEPRVIPQLLEFVHRYKTDVLVDAQEYSTYANKPAVDADDIRLAAMSRLNHTYAQMPSRELMMELAEKRNAIPLPPIPSEYGVRLPLMEHQLTTESIRLFPNHPNQFPNPAMMQQNVAAHPVDYIPSPNMPRGTRNIKVSASPIQIKLGQNMFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XB49</accession>
    <name>A0A6G0XB49_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_006551</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XB49"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021752"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051707">
        <property type="entry name" value="PI-Interact_SigTrans_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336:SF8">
        <property type="entry name" value="PROTEIN OPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336">
        <property type="entry name" value="TANDEM PH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="167"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="321"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0737386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="646" mass="72243" checksum="000DF32A74BE4A3C" modified="2020-08-12" version="1">MRGVRRASEPLELVLEEENGDNGDSMHSSTVASSGYENSIPPIAPFPDAEAMTESSSEPDEYDHEDSDSQYMSLGQQFGARSKQRRQEQRMRELLEQQKAQMQALVQSHNGRGRAPSAGEPMRHTISHDPGMPGNLNAIMNSARPSLVMGSVLQSMPRLDIGGGVRRVTFEGWMLKKGQHVRNWKRRFFNLTGQELKYSESPGGKSKGFGLVLGVTRHLSLPRGLSISLAPNRTLEVQAESTDDQEAWLLHLNQACGKASMDATVTPIPLAPASSPHPSTVIDEVTPPQPVSGSGLQTRRHSSHSNQSSTNYDDSYVVDTQTVCEGWLYKQGQMVRTWKKRWFSLVNEVLSYREMQSSVQVKGYGRVMSVQRSMTTHAFGLVIELDNNRKLNVYAEDADTQKRWHRALAQVLQPKESSAPSLPTSAQTLFKQSKTHGSFIKNFSGWMNIPSGPLNMSWKRCFFTLHGVELAQSDDTPSPVTRVDTVAKVTPWSGKSGGLEFAMTSGRVWKVMCPSIRAANAWIAAVEDCQGRTRYTVDRFLKSCDTKQMQTIVCGWLTRTISKKSVMRQYFVLRHLTLSIASDVDETPEEYDVITGMTPAEKDCALEFQFVSSPKMVVECDTVDALRHWHRIVRTCLNETQRGTYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XBZ7</accession>
    <name>A0A6G0XBZ7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_006362</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000083">
        <property type="protein sequence ID" value="KAF0737698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XBZ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021027"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013111">
        <property type="entry name" value="EGF_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052108">
        <property type="entry name" value="MEGF/SIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24035">
        <property type="entry name" value="MULTIPLE EPIDERMAL GROWTH FACTOR-LIKE DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07974">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026032518" description="EGF-like domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="72"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="342"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="395"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="419"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0737698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="674" mass="69158" checksum="45BD2E007C03A479" modified="2020-08-12" version="1">MRSLPYLGLLVTLLASTVAGGCCNNDCSGKGKCTVGGNGCICQCFTGFTGADCSRRSCPAGRSWSGSAYGVDVAHAVVECSDRGTCDETSGLCQCDPGFTGAACDRLACPLACSNLGECRSIKSMAARKDKGLPPPVVYNQNWDSDMVYGCICHKGFTGADCSQRVCPSGDDPLTGAAGDAIFGQQFNEKQSITCSSTGGTFTLSFRGQTTVPINFNDLVDVMTAKLNALSTITQVLVLYSSTATFACPPGGNVIVVEFVQNFGPQPLLVGDPSNLVYINVGGSVALSVSRLQIGTKENAPCSNRGTCDLTSGICTCYDGYTTSDGKGGLGIRGDCGGLIGSITSCPGLVTCSGHGYCSGSPQYACMCFAGWTSGDCSVRTCPQDLAWFDMAGGNNAAHGLAVCSNAGVCDPATGQCNCAQGFEGAACQRMKCPGAGDPPCSGHGQCLSQARLALLSSLNGDPTPFLYGSIPNNPSTWDSNKVQGCYCDPGFGGHDCSLRLCPAGDNPRTTGQVNEIQTITCTAVSASTFQLSFRSATTVPLATSSTASQITTALQSLPTISQVQVTFSTGSTFCTTGSPTNVVSVLFLSEMGNLPAMRVSGVDATKITSFVINKGGAGGSVQGTTENIECSGSGLCNRAKGQCTCFTEYSSSGGGAVPGLREDCGSIRRFPVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XCA6</accession>
    <name>A0A6G0XCA6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_006257</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000081">
        <property type="protein sequence ID" value="KAF0737763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XCA6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019745"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0737763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="247" mass="28737" checksum="1384F98420EF7F71" modified="2020-08-12" version="1">MTELQTCRYSHGKCKLPRATKKNGTMHTLCEYHRTKACAHQKKLDAKRRTEKLRLLESKKAMQHHAKAMPPIHGDLHLWKEEENRMPQLNADLKYKPVWESHDAMYNQSYTHGGLRNDFYDQVPHSTSLYDDRYSKFPSVGRSSSPTLPSTNLRKDDAPFRLQYAREPSYPAPSYPSPTSYSTSPYVDSNVSVHYDHKPLTPRQSHVVPHHMTTGPEFDGRYHEYYEEPASYGRSFGQYPPQPVFHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XCB7</accession>
    <name>A0A6G0XCB7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_006236</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000081">
        <property type="protein sequence ID" value="KAF0737742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XCB7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010703"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0737742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="308" mass="35019" checksum="79E1577A533EDDF8" modified="2020-08-12" version="1">MHGWIRSWNPSIFHTAMDQANEISYLIGTGRVGGLEDEIGIESSDSDNDSGGQDDSRVQTEATANAYIETYLESFQNISCCKRSCMHKALQSPHKTKAIKSLLSQLNPKASNNSPADTSRFRNMFLSIAIPIGMDADVMASAKRQTGKFYLPFLGEVCSTMFCSVIGIHRNKKPTRYRQHVNDTMLLIPPKHKLQDLPGNKRLKRDVSEAVVNYIDKVSKEHGEDGAVTLRKRKISEGMTTVTASSHKCVWLPAYYTRNNMYWLFVKEYCKSHMDQYELTIRDIMIHRQNHVSQIPLSYNSFVSLWRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XCP1</accession>
    <name>A0A6G0XCP1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cellulase</fullName>
            <ecNumber evidence="3">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ae201684_006279</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 7 (cellulase C) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000081">
        <property type="protein sequence ID" value="KAF0737786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XCP1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013484"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014837"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07999">
        <property type="entry name" value="GH7_CBH_EG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.100.10">
        <property type="entry name" value="Glycoside hydrolase, family 7, domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001722">
        <property type="entry name" value="Glyco_hydro_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037019">
        <property type="entry name" value="Glyco_hydro_7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753">
        <property type="entry name" value="1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753:SF1">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE CELB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00840">
        <property type="entry name" value="Glyco_hydro_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00734">
        <property type="entry name" value="GLHYDRLASE7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026343372" description="cellulase" evidence="13">
        <location>
            <begin position="19"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="14">
        <location>
            <begin position="429"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="14">
        <location>
            <begin position="466"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="14">
        <location>
            <begin position="503"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="380"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="398"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="410"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF0737786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="541" mass="57270" checksum="9713D175A247AD24" modified="2020-08-12" version="1">MNVRAILAALALAAVSNGQQIGTNTPEVHPVLTTQTCTTGGGCTPETSKVVIDANWRWIHQVGSSTNCRNGGSWDGGLCPDPTTCAKNCALDGVDYGAAGVVTSGGNLNVQLNNRMYLLQDDSNYKIYKVLNKEFTFEVDVSKVPCGGNSALYFVPMDQDGGKSKYPNNKAGAAYGTGYCDAQCPGGNAFVNGQANMNNNMGQCCMEMDIWEANSVSNALTPHTCTVDGVYTCVGGDCGVCDKGGCGANPWAMGNHNLYGPGSSFSLDTTKPFTVVTQFITDDNSPNGNLAQINRFYLQNGKKIDNPSSLTDSYCSWASDFESKGGMKAMGRALKSGMVLAISVWTGEMGWLDSGNAGSCPSNPPAVTSAPVSITNIRVGDIGSTTGTTPPPSPPTPSSTTTPGSSPPVTTSPPSPPSPPSTSAPSPGGTVGEWGQCGGTWYNGPTQCQSGLKCQHWKDEYWQCIPAVEIWGQCGGRWYNGPTVCQDGLKCQYWKDEYSQCIPAVEIWGQCGGRWYNGPTVCQDGLKCQYWKDDYSQCIPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XDK1</accession>
    <name>A0A6G0XDK1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_006189</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0738214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XDK1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005863"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.10">
        <property type="entry name" value="endopeptidase domain like (from Nostoc punctiforme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0738214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="328" mass="37014" checksum="9DF37967044F26C8" modified="2020-08-12" version="1">MTSDHIRDLIALFAPDSLSVNRNELDHATDEERQAARFARDQTKPGDIILVTTGGFVYSTGRYFCQQPWDHALLVVDDTKALHVGYPRVCYVSLERVLLPKRQPAIYRVPSISQSPQAQALLQRYAELLQDAPYDIPRALVLIRNLSVEHLFNIKPSSNLSPPRKAWVCTDAIISLLAACSPEFQKQVKQHSKRLHLSRIGTASLKDFLTLHHHSVIDRVPLPPIDYNVQPKPTFDSAYVLNQIAALPNPMDAWEQLNRILRRFAHRMAHQHPAVLEKQIKAMAYVVLLLILFKKHSLVLSVLHRAVQLVRLVLAQATGSPIATVADI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XDT3</accession>
    <name>A0A6G0XDT3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PUM-HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_005794</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000076">
        <property type="protein sequence ID" value="KAF0738358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XDT3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015371"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000004">
        <property type="entry name" value="Pumilio homolog 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF12">
        <property type="entry name" value="MATERNAL PROTEIN PUMILIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUM-HD" evidence="6">
        <location>
            <begin position="382"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="400"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="474"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="556"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="600"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="628"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="664"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0738358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="736" mass="84549" checksum="94ECC5BDB88B8064" modified="2020-08-12" version="1">MMKPEMYDMCLDLDAREQDDTSKNFAIGTRIQRSMSAPPMAEHVGRLPPPMYALTEYDDPQMDPHMHPEYYYYYAPKSHNPRLPMSYHNWEARQQQFQHRNSSLHRVQLAERRRGEKAIDNVSLNLTTTSSKEDFEAAVAAAGGHAIKKIHGEHYCLSPTESSDSNSSSSIRPVTKTLIDRIQEDFPRTPSPVFGYGMQIASHEDPHLSRLADQVALHGEHYSEIPAEIVQSMKRLQMSGDAGKGRINMVHSHHYPSTPPPPPGMHYGSNHTSQVLYDRYHRAMHQTSFYTPDRLYHDTYEPVAMQDMRLLSTPKAYYEHEPTYNRHFVPVHHHPAAGLRSSLPWKPDAARDYSYAHPMEEMQQDKTFREKAKPSQPSTPLHQSILLDDFRATVKTKQWELIDARGHIVEFAKDQHGSRFIQQKLETAKTDIKDIVFSEVFPVALALMTDVFGNYVVQKFFDHGNPDHVLQLMHIINGRMIDLALQMYGCRVIQKALESDYHAEKLELICELEGQVLRCVKDQNANHVVQKCIEVLPWKDPSASRYIERASFLLAAFEGNVYSMATHPYGCRVIQRVLEHCSDVQMATILVEIQDACSLLVEDQYGNYVIQHVLQHGQPAERSALINKIYPDIVRFSYHKFASNVIEKCLMYASVEQLHVIMRHVMDASDGECPLQVMMKDQYANYVVQKLIDVADASERDKMVAIIKTQATLLKRFTFGKHILNRLEKLTGYKMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XEH5</accession>
    <name>A0A6G0XEH5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_005520</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000071">
        <property type="protein sequence ID" value="KAF0738592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XEH5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012945"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004798">
        <property type="entry name" value="CAX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00846">
        <property type="entry name" value="caca2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00378">
        <property type="entry name" value="cax"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF22">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0050">Antiport</keyword>
    <keyword evidence="5 9" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 9" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="316"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="377"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="70"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="252"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0738592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="399" mass="42489" checksum="8999CA80A5883879" modified="2020-08-12" version="1">MVNQAKNEALKAVKQESLEEKLPLNGGSAEEAHATNDFQAFKDIVTGSAINWLLLVAPFAVWAYLGKWGAVWVFTLNFLAMMPFANILGEATEALAEHTGDTIGGLVNASFGNAVEIIIAIFALKSGEIELVQSSLIGSMLSNLLLVLGMCFISGHLGGAKESEFNGVGASINMSLLFVASFAMLIPSYYAQSRSGVASDQVIEIAVLSLSRLSAIFLVLMYAQLMFFQLVTHKATELGGEGHRPSISMLGATIVLLVATVAVAFLSEYLVSSVDELTSTSGIPKAFIGIVVLPIVGNAVEHITALKVAYKNNMELAMGVAVGSATQISLFVVPVCVIAGWLMNVNMTLAFNTFEALTYIFSTLIVYVIVADGKSNWLEGSMLLMLYVLVGLALLEITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XER9</accession>
    <name>A0A6G0XER9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tripeptidyl-peptidase 2</fullName>
            <ecNumber evidence="3">3.4.14.10</ecNumber>
            <ecNumber evidence="10">3.4.21.62</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Ae201684_005344</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>Hydrolysis of proteins with broad specificity for peptide bonds, and a preference for a large uncharged residue in P1. Hydrolyzes peptide amides.</text>
            <dbReference type="EC" id="3.4.21.62"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.10" evidence="3"/>
    <dbReference type="EC" id="3.4.21.62" evidence="10"/>
    <dbReference type="EMBL" id="VJMJ01000070">
        <property type="protein sequence ID" value="KAF0738724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XER9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000305"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007901"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04857">
        <property type="entry name" value="Peptidases_S8_Tripeptidyl_Aminopeptidase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000003">
        <property type="entry name" value="Tripeptidyl peptidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034051">
        <property type="entry name" value="TPP_II_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046939">
        <property type="entry name" value="TPPII_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048384">
        <property type="entry name" value="TPPII_GBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048383">
        <property type="entry name" value="TPPII_Ig-like-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022229">
        <property type="entry name" value="TPPII_Ig-like-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046940">
        <property type="entry name" value="TPPII_Ig-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF14">
        <property type="entry name" value="TRIPEPTIDYL-PEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12580">
        <property type="entry name" value="TPPII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21316">
        <property type="entry name" value="TPPII_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21223">
        <property type="entry name" value="TPPII_Ig-like-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 11" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S8/S53" evidence="12">
        <location>
            <begin position="33"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Tripeptidyl-peptidase II first Ig-like" evidence="14">
        <location>
            <begin position="527"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="Tripeptidyl-peptidase II galactose-binding" evidence="15">
        <location>
            <begin position="664"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="domain" description="Tripeptidyl peptidase II second Ig-like" evidence="13">
        <location>
            <begin position="789"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="11">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="11">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="11">
        <location>
            <position position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF21223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF21316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF0738724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1250" mass="137749" checksum="40E37A495E3B867D" modified="2020-08-12" version="1">MTSAVKFSPSTEIVPKHETLASQLLQLYPEYDGRNTIVAIFDTGVDPGAPGLQITSDGKRKIIDVVDATGSSDVDMSTILKPTNDGKLVLPSGKVLTLNPEWKATEFRVGSKRAYELYPDQLADRISRERKEKWDIQQREAINAVQKELADWTAANKDSPSQAAIDTRKDIQARLAILEANAKSFQDPGPIYDCVAFFDGTHWRAAVDTTETGDFSTTPAFTNYRVAQEYGKFSDASQLNYALNLYDNGSVLSIVCDAGAHGTHVAGIVAAYDKTGPINNGVAPGAQIVSVKIGDSRMGSMETGVGVTRGVRAVLENKCDIVNMSYGEFASKHDAGRVIDVIRDLVEKHGVTFVSSAGNSGPALGTVGAPGGSSSSILGVGAYVSPAMMQAEYSMRDTPASAVGLYTWSSRGPTYDGDIGVNVCAPGCAITSVPNWTLNKKMLMNGTSMSSPNCAGNVALLISGLKARNIEYNLFSIRRALENTAVSVPTADAFSQGRGLIQVLPALEHIFQYKNAFDGTKEFPLYYDVRVPAHDNSRGIYLREYSQLVENDFVVNVQPIFHKDARNDHRIQYEMQFRLVPTKPWISCAEHVTLMHQGRNFKVAVDSSSLPAGHAHYGEVIAYDAKNAARGPVFRIPVTVIKPEVIPENQEHKALQLVKELSSGNISRNFYKVPAGATWVNISVSRHGAAPQEPERAIYALHLMQHELHERQSSTSLQRTFNLGSTEQVTHSFSVKGSATLELCLAQNWNAMGTSKVHVEVDFRGIIPDERTVHLTGGAGSVKVNLFAQLRNESIEPSAVLNKWTQRLRPDSAVVSPLGSRDVFDDNRHVYQLVLTYSFEKVEEGKITPTLPLLNGRLYESPFESQLILIFDTNKKYIGCSDAYPRSTNLKKGKYVLRAQVRHEDPSILEGLKSMVAFVAHDIKDIAVTVYDSPNGPSVQGKALAAMSLKKGVYKPVYVGEPAFDKLPKGVTAGDTLSGKITYGRKSTDVKGSTQKPNGYPLTYTVPAKPATEKEPEVKPVEDVRDEDVLAEEAVRDLLVKRLVSLQGKDTFTAQWTKLIPKYGTHLPFLQTRLHHFDNDSSKRRESLKEIVEAATSIVGAIDTQALAAHYGVKLVPGDAEQAKIRKQRDDEKAVLVDALTRQARALGDLKEDAKFVQVFQKLQQWVDIDGNQYIYAALHNDLRQGHKGSALKRLQKVSELSVEELEKIIPLKEVQDLRVQLYSELSWTQWVEYEKKWKILNYPSSYMPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XFW5</accession>
    <name>A0A6G0XFW5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_005310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000068">
        <property type="protein sequence ID" value="KAF0738940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XFW5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016049"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0738940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="325" mass="36268" checksum="EECEEA368C12861F" modified="2020-08-12" version="1">MKSPQRIDPQKWAAECADIFMRSLEADLYPPKEIERMFGVVKSTEPEAVGKLVFNVWIGLWKTDYFQGREDLTRVLLTGDLPKWFEAKVLKQIKDVKQAGGYLGYYLLNLIDRGFAAIPWDYELLDLAKIQSVMGLVVDGSTVTPKQVVLDASFQPCPIAAAAGIPLVVKKLQGKGTKSNVYIISRMMSEPLIGLARREWSYGGMHGVAPQVLAARRDNVAFEPSDWYALDDFEMEMLDDGPRRVTRDDFVRWAKSYFKPDSRIVMEAKFPEGQAVRVHGLVSNQDLNGRNGSATGQYASGRVGVNLEGRNAPVAIRPNNLSVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XG15</accession>
    <name>A0A6G0XG15_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_005185</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the activator 1 small subunits family. CTF18 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000067">
        <property type="protein sequence ID" value="KAF0738996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XG15"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000498"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053016">
        <property type="entry name" value="CTF18-RFC_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46765">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46765:SF1">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="10">
        <location>
            <begin position="227"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="31"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0738996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="745" mass="83926" checksum="AE013F4E530D87F0" modified="2020-08-12" version="1">MEDENIDEWELMYGNDMEAANELVVTQQEIASMPAPAVSHPSPQSSDPLQVQNSEINDYDMDTSEPPPNQQEEEEYILRRPSLVNPTIACVLASGERVFIKKKDEEPRFMRSKATNQNVQWKLASSVKTLLEEIHNRAVEAVVEEDRQKEEAEYVADVVNPVTENNLWLDKYRPRHFVDLLSDERTNREVLLWLKSWDATVFPQKVKTNTPKSKLPEQNKAGDMRPEQKIILICGPPGAGKTTLAGIAARHAGYNPIEINASDDRTAGVLKEKIISAMEMQSIFGDQRPNCIILDEIDGALSGQEGKGAISALQALVTAPYAPRSKKGKKAANAGGHPLIRPIICICNDQFAPVLRPLRKLAKIFIMHTPEPRQLMQRLKYICKQEKVQASNSLLSTLCLRADNDVRFCLNALQFASAKTSTLTLSMIDNMMGRKDVSKGAYDVWETVFYESKEQQKNDSDSFSRVFEATDRFGSQDLILSGLHENLLPLAFNDPTLSKIHNALEWMGFADLCETRVRAHQQFALTPYTSVAAVSVYRACCTSSRRRIEYPKASYDCRKKIESSQSIIEALVEPGVNLRLGSRVLTLDVIPWIVSMLNPAINSAPNHNSKEPMDRLVALMSSLHVSYKQVQMPGGVVEYSLEPSLDMLVKYYGLEPRMRLPLGIRQTMAREVELENLRRADKGNKIPVEAPAEVSTYDMSNPFGLKKRKREDQTTSNAKRWPIRFKFNEGYTCGIKRPVLVQDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XHT3</accession>
    <name>A0A6G0XHT3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_004632</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000061">
        <property type="protein sequence ID" value="KAF0739825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XHT3"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0739825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="80" mass="8593" checksum="C6D5929DD3E8B7CE" modified="2020-08-12" version="1">MLQRQQFPVDSWASCGSPFLESVAPSSTSVHSTSIFYNNLLGLPSYHSFQAVATSALGKTKLSGAIVNLSCLLIQMSEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XIG7</accession>
    <name>A0A6G0XIG7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_004377</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000054">
        <property type="protein sequence ID" value="KAF0740139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XIG7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003172"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14210">
        <property type="entry name" value="PKc_DYRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF22">
        <property type="entry name" value="DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="185"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="58"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="489"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="506"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0740139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="546" mass="61119" checksum="DA57ABB1F23CF1FA" modified="2020-08-12" version="1">MELPLLRQLPGHRKHRISQVPKPIDGRPALPPPVADPVVVNDKTKAMVVADAIKHQAHHSEKQIAMPRGPEFVAPVKEPPPLRGFDHHASSTRLRSSSSRNSSRRRSSSTATSIQAARTPQEVLACKDSACELTPFEVSEIVAFPLVYCIATADVKLRNGVSNQGFDDDKGDYIVNVHDHIAYRYDVVGHLGRGSFGHVIKCYDMATRQMVAVKIVRNKQKFQEQSIVEAELLKHLNTAEGHASSNVVAMLETFTFRNHLVLVFELLSINLYEYLKLEQFRGLPIPLLKKIATDILQCLVFLGTHGVVHCDLKPENILLRKPRSSQICIVDFGSSCMHNKTFFTYIQSRFYRAPEVILGLPYGSPIDMWSFGCIVGELFTGYPVFPGENEAEQLACIMEVFNVPPKHMIDTCKRRKHFFDELGTPIATTNTRGRRRRPASRELKALIKCQDAKLVDLLFKCFRWDPATRLTPREAMEHDWLAAEKNKPMAAAPVVPSKPPTEKTAPGSSSIRSSLTTFLRKPMLPPAQENDDGGRVELSAILPKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJ13</accession>
    <name>A0A6G0XJ13_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_004258</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000053">
        <property type="protein sequence ID" value="KAF0740256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJ13"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016752"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="448"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0740256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="565" mass="63172" checksum="9B536A71FCE60806" modified="2020-08-12" version="1">MPPAALSPLSHSPRRQFHPSPLAIQTPKYHSPFSQYQPSATDRPSLKREGIATLESTRQRMSFVSGNSVILLQNSHPDVPNVPFHDEDDDEKALTLGRAAWIVFSSIVIGAVFLSVMILFKGNGIIFLTSYLLPIINYEMSWYSHAIIQTLLRPFQIYYDMDAVATATAEDKSKTTVAQTWGGRVGASDKAMGLVISTLVMFLCAGVTAVLQLYGNLGLSSMALYMVLPYVATTTFVAVGCAMFTPSPMDGCILLLQQIAFSVAAFNSFFSYKEAVHGGVRQITLVDGGYSIAIVLVPIVIFRIVRSTEVVRTGLVLLLDLFCVQYVTSTLMLLATIVDNFLAQDQVLVDFPQHRMLALVSCFLTLWVTDLVTQLLIRRPKWAIVACGIIASIIATVVLKYAIAPPKVELCQWYHIVFIVLGSCLCHVGKSFVAFFRLLAGNARLSRWLVRLQYLLLLGVFVMLYERVAWVETFSTTVDDSIRMVTQMWVRIDNTSYQAFDQNQSEYQFLYQVRTLMEMVHASYTPAKMDAMFVRNTHHFLFDVGTCVVQSIQENVTGMQCFSMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJA7</accession>
    <name>A0A6G0XJA7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Regulator of telomere elongation helicase 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">Ae201684_004426</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000054">
        <property type="protein sequence ID" value="KAF0740195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJA7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016417"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070182">
        <property type="term" value="F:DNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045910">
        <property type="term" value="P:negative regulation of DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904430">
        <property type="term" value="P:negative regulation of t-circle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010569">
        <property type="term" value="P:regulation of double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090657">
        <property type="term" value="P:telomeric loop disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17970">
        <property type="entry name" value="DEAHc_FancJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16449">
        <property type="entry name" value="RING-HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000431">
        <property type="entry name" value="Regulator of telomere elongation helicase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057498">
        <property type="entry name" value="Rtel1_ARCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF34">
        <property type="entry name" value="REGULATOR OF TELOMERE ELONGATION HELICASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23109">
        <property type="entry name" value="ARCH_RTEL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00491">
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        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0862">Zinc</keyword>
    <keyword evidence="17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="20">
        <location>
            <begin position="7"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="19">
        <location>
            <begin position="884"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="724"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="724"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00073810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAF0740195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="941" mass="104782" checksum="A8B0F2C60FEE828B" modified="2020-08-12" version="1">MPTLNICGVPVSFPFEPYESQLVYMEKVVRALESKQNAMLESPTGTGKTLCLLCATLGWRVHRKKQLKSQSSKKKLQYEDAATEDNEEANEETNKLPKIIYASRTHSQLKQVVKELKQTAYSPKIAILGSREHLCVHPEVSKMRGTQQNHTCRLAVRAQKCTYKLGYDQYVKSKKNIANLPIMDIEELVTTMERRETCPFYLSRDMLTSADIVFMPYNYLVEPFVRNSLGVTLENAVLVFDEAHNVESVATEAASYSLSSVDIQGCIREVDECHNLIVSGRVHPGEDTYLSSQSATTLKNLLVEILAGLNTFPLNDKGGCTKPGSFIFDFFKQFNISFDTAPMVTTITEQVIEAMSDYAQSNPRNSKLDHLLTFLRTIFRDKENHQAMAKQYRVHIQEENAPRTRQTSNRPVNSTMRMFHYWCFHPGVAMNELVENNVHNIILTSGTLSPLDTTIKELGIPFPITLENSHVIDPSQVWVGVVGVGVTGKKLNASYESRNSPDYVLELGNTLVNITRVVPNGLLVFFPSYSILDMCISQWQAQGSNIWERLQGLKSIFVEPKNRVEFADVVQSYHACIAANPNGAIFFAVCRGKVSEGIDFSNENGRAVVITGLPFPPTKDPKIVLKKTFLDNLVTPPGEMKLSGNQWYVQQASRAVNQAVGRVIRHRHDFGAIILLDERFAFHQQKGSLSKWLQPFVQIIPSYGAAHGALTRFFKHNKEQATAAAQSAKSATKPTKSIDTKGFVPPKKITNLPAPPVEKPADVIASQVAIGDGQTFVPPTELSGPAKKSSTDAPVSLELLVHQARTLLSSQDMTAFVTYMRDPKNHLDEIEAILAPHPTLQQRIAPLLPPRNVAQAMYQLQRLKKRKHPGAALATTTAVANPQCSICFDIVQTTSAPPCGHLCCVRCWKKLELPDHTIQCPVCKGSFHVGQFTPIVAKRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJC3</accession>
    <name>A0A6G0XJC3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Gamma-secretase subunit PEN-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_004149</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PEN-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000052">
        <property type="protein sequence ID" value="KAF0740413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJC3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005188"/>
    <dbReference type="OrthoDB" id="524898at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070765">
        <property type="term" value="C:gamma-secretase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019379">
        <property type="entry name" value="Gamma_Secretase_Asp_P_PEN2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16318">
        <property type="entry name" value="GAMMA-SECRETASE SUBUNIT PEN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16318:SF0">
        <property type="entry name" value="GAMMA-SECRETASE SUBUNIT PEN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10251">
        <property type="entry name" value="PEN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0740413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="14500" checksum="044F30736582DA53" modified="2020-08-12" version="1">MARDDSNVPVLESTREERANNNRGNFTRNLDKEDDSSVARKIFFGGLCLLPWLWAVNVFHYRAQFLDATIDPKTTLWVRRSFLGFIIVTLIFIAWVVTFQLSWKAHGWEKLLLFVPPEDLDQGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJT4</accession>
    <name>A0A6G0XJT4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_003947</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000048">
        <property type="protein sequence ID" value="KAF0740570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJT4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010262"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="103"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="187"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="467"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="248"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="112"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="188"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="467"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0740570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="491" mass="55759" checksum="F1FF86216FFDB503" modified="2020-08-12" version="1">MENTKIKLKLGAKMRSSIAIAEQPRRRNSVQNHRDVSRYLFSTFSVRSMQRSLSRANSHHRISVTSNAGQGLATYSKLSVSMTYRNRQSTVYDESNNSFLRESNLEDKSRMTNESTASVASTYCSSRDSSPSYVQPRTLERQASTVNSPINTIREDSDVSDVEIAAMQAKRALRRMCLSLVTLNQQSDEIDDDDEDDDEDEGVSSVGLKFPLESSDEDDEDESFVAPVKTRAKPRLDSDLITISRADLRQFQSRLKMLEDKLAAQADAQADLEENIEREVRARTKKIEEQYEEKIEELTMARDLEVDQEIQRRLSEFSASSSSVDSKAKTPGHKKGLFRGKSSVTDLFRGSNVSDLDQFKEFLMNNSKRMSDRLSRSTQMDIFNLREEGDGHGSSELVDTVQRLRHVVHDQDEQLEQAKYLISVAVVKMNVTEEVVNDAFEEMGKMDARLERQAQEIAELRRQSSTYSSVSFNSSVSLQQPPVQRASGRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJU0</accession>
    <name>A0A6G0XJU0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL49</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_004137</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL49 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000052">
        <property type="protein sequence ID" value="KAF0740401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJU0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005178"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007740">
        <property type="entry name" value="Ribosomal_mL49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13477:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13477">
        <property type="entry name" value="MITOCHONDRIAL 39S RIBOSOMAL PROTEIN L49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05046">
        <property type="entry name" value="Img2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0740401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="158" mass="17781" checksum="999457E7F4E1B0B0" modified="2020-08-12" version="1">MFPRSIIVGVSAPLRVASNRQINRKLKHPATLRKIARKEAENPVEHVLPPLKYQPTYVPEKVSFNGWSPARAEGPLDGIPFHVKRTATGLQLPVYRDYRNGRTRVITIVRRFHGDEAELQQELSTVCKGKPVVSRPGRLEVVGDYAAEIKQYLTGLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XKN2</accession>
    <name>A0A6G0XKN2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Calcium-activated potassium channel BK alpha subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Ae201684_003882</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000045">
        <property type="protein sequence ID" value="KAF0740750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XKN2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012783"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005267">
        <property type="term" value="F:potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003929">
        <property type="entry name" value="K_chnl_BK_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047871">
        <property type="entry name" value="K_chnl_Slo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027:SF10">
        <property type="entry name" value="SLOWPOKE 2, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03493">
        <property type="entry name" value="BK_channel_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22614">
        <property type="entry name" value="Slo-like_RCK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="319"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="13">
        <location>
            <begin position="139"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="15">
        <location>
            <begin position="359"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium-activated potassium channel BK alpha subunit" evidence="14">
        <location>
            <begin position="499"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="15">
        <location>
            <begin position="706"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF22614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF0740750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1064" mass="118163" checksum="E1A3EC8102E2BA40" modified="2020-08-12" version="1">MSHQLRQRRQSETSAVDIELALLEADLQSPPKQYEAAHTPPRHPSDTMRYGSEYDDVSSNGLATPVVGEASHSFHRFEISSESTDRLELKISSPEIVRLVNAPHARKQTSRPPRDMMVYVPTSRDTIRACLRSSVGVYLEVTNTFLSVLCCVTYLIELYCPDVYSSWHFRQVELAATVYFALHYALHLYSEEDTCAFMLSFNGLIDLTIPPSIVMYFVSDPSAREVTIFRVLRVFRALRVLRLHSLTRSRKHGYNYEWGVFIFSIAAVTFVAAGIFHALEDYPDRDRPLQFHDSLYYILVTLSTIGYGDIVPTRVLSEFFVMGLIICVVTTVPAQISRLHALHVANHPYDGNYVSRPGRGHVIVCGHVAHDAFADFLAEFYHPTRGVISFDVVVLCDAPPSPAMSRLLSNINFANKTKYLRGSLVNDVDRQRTKLDSAEAVFVLADKDTAMSEAQDAATLLQALSIRNFADSAGCPIRVYLQMVSDAHNELSHIIGANQTINSNRIKADLVCRGVVCPGSCALILNLMQSVDQAKMRKLVPNPSPWMLEYIAGMSYQVYAILLSDAFDGHLYEDVARRFYNGFEVVLLAVYRRDSADDRPSVRLTPFGKPLRDGDIGFILATNAAVVPTIQANYSALVENEVLPPSPRSSTRAVPFISKSNLLQRLTPRNVRRVTPSPMACSPSTSDNNTIDAQLSRTIQKDLAAIRGHVVICGATRHVLPLVLLLRQMYDQIDGTNTPALVFLVDELPTAASFDQDAVLPDEIFFVRGVSTKCADLARVAVQHAKAVLLFPLASHNQDHVEDLIDYDVVTSLLCLETACDPSHAAFGKQTAAARDEVAFYAQQHDRVPLTAVQSRMRSHFPKLDPTLFQEASIQTLSHRLSFARLSMPPASSSRMKLQHGLCDLPSVAVLQRGSNMKFCRPRDGPFGGDAIPYLSPAYAAGRVFVDSRLDLVLCQAFYNPYITEILHALTGSPLEMADDDDGAPPSPLLVQADIPSDFVESAFGDLFVAMLRQNKVVLALYRYPHASLGNVIPYVLTSPAASLQIHPRDKMFLLADVVHHRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XLW6</accession>
    <name>A0A6G0XLW6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter Family</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_003138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000036">
        <property type="protein sequence ID" value="KAF0741452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XLW6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004567"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0741452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="337" mass="36665" checksum="876455A22E7BCC99" modified="2020-08-12" version="1">MDDCACGALLRVDGHHVQLDPSANWFVDCRLAGNRQVTAASIGQGYSIAGSLVVSGYISFFGPVHQSIKPFMGMLMTIMFVTCMHSVCYFVKDEQYIPAVKPDTKQQLKDAFSALYVGLRKLPYVLAIYCTIFLLLQYGYTAYNGAKGQFFGIRVKDGIATDADTCGKEGNPACTDRQKAYNDGVQLAGGVTDTVFNLMGWAYLACMPFLVRKIGAKWVIVIACIPQVLLIVMSFCKVVAIDMIIVILTSVSQQTIFVLQLPMIVVQIGLAADNNLGMYAGAFNSAQCAGQFLNFALATQLVKTSMTFALPVLIGGILSTMGLIIAIFFLKFDMKTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XM19</accession>
    <name>A0A6G0XM19_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_003146</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000036">
        <property type="protein sequence ID" value="KAF0741460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XM19"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019916"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008506">
        <property type="term" value="F:sucrose:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432:SF26">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13347">
        <property type="entry name" value="MFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="452"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0741460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="481" mass="52418" checksum="6E956F998DB2810C" modified="2020-08-12" version="1">MASKIEDAAVPVTPNDVDYVQKDAEGLDVVDKSQQEGMSIPMMFLVCCPKMAMNMAWAAQWAALGPLLQVLLSYSSVQGVQIVGPTSGLLVAPFIGVLSDATISKYGRRKPWLFWGAVTSIICWAVMMNATDIGNSLGDTPDDRTWTTVFVVFCYVWMDITCNLTQVPVVLLIADLAGNRQVTAASIGQAWSIAGSLVVSGCISFFGPAHQSIKSFMGMLMVIMFVCCMSVCWFVKEEQYIPTVKVDTKQQLKDAFSALYVGLRKLPKVLALYCVIFLLLQYGYTAYNGAKGQFFGIRVKNGLAPGADTCGTKDYPACTDRQKAYNDGVQLAGGVTDTIFNIFGWIYLLCMPFLVRKIGAKWVIVLCCVPQVLLIIMAFCKVVIVDQIIVVLVSISQQTIFALQLPMIVFQIGLTADNNLGMYAGAFNSANCAGQFLNFALATQLVKTSMTFALPVLVGGILSTVALFVAIFFLKFDMKTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XMS2</accession>
    <name>A0A6G0XMS2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_003385</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000036">
        <property type="protein sequence ID" value="KAF0741720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XMS2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020860"/>
    <dbReference type="OrthoDB" id="59311at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000158">
        <property type="entry name" value="Polyubiquitin 5"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="77"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="153"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="229"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0741720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="305" mass="34368" checksum="7219EA927113E786" modified="2020-08-12" version="1">MQIFVKTLTGKTITLDVEPSDSIDNVKQKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLDVEPSDSIDNVKQKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLDVEPSDSIDNVKQKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLDVEPSDSIDNVKQKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XN57</accession>
    <name>A0A6G0XN57_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Beta-lactamase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_003090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the hcp beta-lactamase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000034">
        <property type="protein sequence ID" value="KAF0741904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XN57"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011345"/>
    <dbReference type="OrthoDB" id="272077at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040239">
        <property type="entry name" value="HcpB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13891">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13891:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0741904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="227" mass="24710" checksum="8B6AE03DCA8B48BA" modified="2020-08-12" version="1">MSEKSAEETKRLNEELQKRHYEFVSNCDDGNGDASACHSYGEWLAVVDKKYDEAAAVYKKNCDKKNYPASCFNYGRFLLAGKGVDLNDEEGRKMMVKSCNAGHTHGCHHLGIMYLNGIGGEKNVEKGIAAIEKACNNGEGSSCYRLGSMFLTTQSKYGIARNVVKAKKYLESACDANFAPACHNLAVMYKTGDGEVKKDPALYEAYSLKTKKLAEQSGAVGGGVRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XNM6</accession>
    <name>A0A6G0XNM6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_002934</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000032">
        <property type="protein sequence ID" value="KAF0741994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XNM6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014024"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0741994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="781" mass="85801" checksum="D07D8782F1F7B796" modified="2020-08-12" version="1">MAETARSRLNSVYALVDEMSLRRGEESATKEQASSLWDELQARGLNETDAWLCGALVKRLALAACSPMCKASDHIVVIGKLSEAKQTNEADRVYIASAQCSALRHLHAVKPAVVRPHVNTTQFVPVVRQSANMMDERKQREEVLKICRDVLLSADSYDEAENMCVEFIDNEGSLSEIAIDGLLSLAAKGRILPFSLIATTQALVSTAKGQSNQLAALRLFRVVATQHAKRPGVIGDALNLLCTHSMHRSPVIRREVAHAFRFFPPPTSATLSQLLLKTPLEDGASHLPTEVLQTGVLLSLLEDQDVDVRCEASRSMVTLCRPVLHQETNRVEPSVAALEKAITAHADLVHAGSIDAKLQITRSLVMLLQQHRRRGHGGFAFTPEQMEYLVAGAPASLEHAVSLLAVVSACELRHIHHASQAMDFTTTVESLSNLPTTRAALKKHMQVQVAEIRRRAFALLELDATLHAKYCSLRRKVEETLSNASTSSRVFLLAAATPASPVRGSLVSILPQSADLKLKERQIQAARAAFSGSTTEQRYGHQVVDILEATTKVTDPNILVDKARQLLVQFPSTPRDAVHEVIKSAQAILFAADDMRWTHQDEALALLRTHFPTVSTRDELQADAQSRLGKWWPAQVLEHVPQTSIYANVDTTSVDMVVGWTSDVPVHAIVYGLDDPTVLTIQVGSKDEGFYYDVLPRDIEWLDRHVWRIRCAVPVTFNTEFHPSLDLTFCVKTTLPSLFAQDEAVVVSISPRVPVSLTLSRSVRAATISVAPAASPTHCHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XP80</accession>
    <name>A0A6G0XP80_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ae201684_002861</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 12">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000030">
        <property type="protein sequence ID" value="KAF0742195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XP80"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000764"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10509">
        <property type="entry name" value="Zn-ribbon_RPC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019761">
        <property type="entry name" value="DNA-dir_RNA_pol-M_15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034014">
        <property type="entry name" value="Zn_ribbon_RPC11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF12">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01030">
        <property type="entry name" value="RNA_POL_M_15KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 9 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="13">
        <location>
            <begin position="79"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="10">
        <location>
            <begin position="4"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="4"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF0742195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="121" mass="13998" checksum="D6F5D0636E8C24B5" modified="2020-08-12" version="1">MHFCPTCGNLLMVEPDTDGMRFCCQTCPYIYKIESKVQKKVPLQRKQVDDVLGGDQAWENVDQTESLTSFVALYLMFSSVARCPFCQHDKAYFMQIQIRSADEPSTTFYKCVACKKQWNDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XPM2</accession>
    <name>A0A6G0XPM2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_002864</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000030">
        <property type="protein sequence ID" value="KAF0742198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XPM2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000761"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="367"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="156"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="406"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0742198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="606" mass="68502" checksum="5188FEE38DB2A1EF" modified="2020-08-12" version="1">MLKCASVRSPRPSGNQDVFQLPPGPKTQLWEKEFSVLFDERKPIGLGFIPVKDATYACSVDNVVSNKIRDNHAFDHNEHCYMSCDTSRVIVPGLRIRAINDLDVEQLSFDAVVAKIKTAKRPVLLTFADVSSLCLATTPKIALPEAPTTESLAAEVVRLRELLQEATLAKEDAERQLENFKKWNQSLLTTNDEMGDQQLHVMEQIRQDRQALEDKQAQITQLQTERDHAQQALASALIENRGIQERLEHLHSRLEETQAAKRAVDDKLAALERKRGDELYLVDKLHREILVEDNNTNELDKLLHAADDKPDVNQQDKHEETMAKLRMQRADHAAQKAALEAALANANAQAQADRQLIEQLQVEKERLQNAAQPSIEPSSSSASMTTTTAPSKEELDALRTRFDTAKLKWNAQKEQWKAEKAALQARVHALEHHGHELERSLTTSQLATSEQQQNALEKEQLDEMILRDFVQRMSTKGWRVHKHGRRGDSHERYLYMDPAGHWLSWTSVEDARHEDAFRHPNKKIVVDVKDIVDVLVGKETQILSKKAAAPPTRCFSLVCAKPCRTIDIQADTPEQCQRLVQGFRLLHAKLSKRALSSSSSSAINVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XPR6</accession>
    <name>A0A6G0XPR6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">Ae201684_002672</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HRD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="VJMJ01000029">
        <property type="protein sequence ID" value="KAF0742268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XPR6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009396"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16479">
        <property type="entry name" value="RING-H2_synoviolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050731">
        <property type="entry name" value="HRD1_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057992">
        <property type="entry name" value="TPR_SYVN1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058051">
        <property type="entry name" value="Znf_RING_synoviolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763:SF184">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SYNOVIOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763">
        <property type="entry name" value="RING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25563">
        <property type="entry name" value="TPR_SYVN1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="290"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="340"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="546"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="360"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="419"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="550"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="578"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="616"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="641"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF0742268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="666" mass="73963" checksum="8836F800627BB9F9" modified="2020-08-12" version="1">MRFAIYAVASLLVGAALIGYTFHTRKQFYPTVIYLVTSKVSVMILCNVALVLVILCGRMFKRIFLGTLRDAELEMLYDHARFTIAETCFTLSVFREEMSLRVLGLFTLLLFIKTFHWLCQWRGEHIEQSEVVSRITHIRLVLLMALLSAVDMTFVVVSGLQVAERGPSVLVLFGFEFLILFVTLVSIFMRYVLHLIDARVEGTWTNKFTYVFYLELFTEVVKLIVYLVFFMIIFTYYGMPLHLLRDLWMSIKSLQRRIVTYFRYRRITANMNERFPNPTEEEMNETDRICIICREEMTLDASKKLPCTHIFHLNCLRMWLQRQQTCPTCRSNIPIDAVRRPDIIPGQNPPPRDGVAPDLPRQQNQPQAAQQPAVVPPAADPLRRDIPARNLPGFNQPVVPPQGGPAPATHTPPVLPRTQAAQPSVTQPPTAPTQDPNRHATGLPSGAPTSTGLPTELPSAVPSGVPGGFAAGIPSFGTMPFNPLTPETSAHYIQSLHYGLQLDPRFLQYQLDMLQAQLHVLRATSLALQSQTGLNMSMPFVGVPPPATATPPTTTSVPAAGPASTNPEIPRANPPSAPVVTASATATTTNLPVNSVNNPSSPTPVTPIASTQGSIAPVPAEAPSEAQAPEPQPAVELTPEEQERERRREELRRIYSKRYASSSDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XQ62</accession>
    <name>A0A6G0XQ62_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_002533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000027">
        <property type="protein sequence ID" value="KAF0742431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XQ62"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002394"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="486"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="545"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="491"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="641"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="671"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="716"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="750"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="788"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="802"/>
            <end position="854"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0742431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="854" mass="97087" checksum="2C32EDCED86D59C9" modified="2020-08-12" version="1">MHAVWLYSLERELMLAKQDELVRPHTSFSESRPRRHKSKLSASATTLSPLPSRQNQNRDEDAQAKKKKQEENHACWLAWCEQKADKLRQEKQQAASTKKNEMDKTKQSKAPAFSMEACFAEWKRTKRRQQKEQEQAALKQQAYERSLVEKYMAEKRKQIQERQGALARLKAQTPKKKKKRHVVVPPPAAFHKLIPIEYVSPKFQAEMERKLERQLDLHEDEVTHRSNFRDAKRAKETKRFQAQMHSSHAHRADSLDQLRHWATPTREIYVLASLLYKLVALESQSTTRLVDVWRWLPWTLVRTIFQDDLVETLQSMPIVCLAPITLTILYFHCAQPHFSTEEIEARSSVGAAIRLWVNNVAAVHELVDPTTQHVRAIDSLKSAGVSCRDIGTLVLLLHVYPHVNFKLKDQTHYSDKQLRERQVDCDLLRELYAAAAPQPPPPLPPSLDQVEPSQLLGLLDLPTFAPSKTRSKLAARLAARLQERHNDFDESPSSPSHSPRASTPHKSLQDDTVVVYKLSIPSKQQDHELNPLNYIQQKRRDSSLRIQTISTNRRSSLVTANQKIPLATSNNRPTDSRRSEPRPPMLSTTSPSAQTLPVHPELPAASISTPQTSPREEQESSTLLLPKTRECRIDTTSLEGDNTKEVERHHEHGPAVEEEESSKPPLPGFPRAEKAPKDEHEEERQLDNGYAAEEQELSSLLLPETPGAPQVAVNEVGHDGKGDKMYLKDGPNAVVDEGANGDNVEEDVERNDKDGPAVDDGHDTSVDLSHDAFQDMHQDKTPQPSAETESREHEAPEKPNDEDVDDQYAEEEDEDLGHDEEFQDVYDPRSEDEDTHGDGDDGETPLYEDEFDNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XQM4</accession>
    <name>A0A6G0XQM4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_002357</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000025">
        <property type="protein sequence ID" value="KAF0742655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005690"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1035"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1099"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1127"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1166"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1192"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1233"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1299"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="145"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="178"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="220"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="779"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="812"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="447"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1400"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1593"/>
            <end position="1637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0742655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1639" mass="185495" checksum="30C26709A27FFDDC" modified="2020-08-12" version="1">MSEFKETAQSETKYGSFAEGNPTFVGDDDDDVDDGDDGGVEDFKKSLIQLFQESKFSVITSRLQAGILTEDDYSSAYGYSIMSYAALLGKEDILQLILKRVNYKKIYDYAYDPIYQAAKKNRRGIVRILLDNIKDIDLTSTLNTEEWTVLHVAAANGFNEILEMLIEAGAPVDIVDGSGLTPLHYAAWEGHRRAAEILLENGANIDKQVGMEGQDLEEYDGWTPIHFALASDIDDVEYMRVMVNFLLRANASLDIQSKDDQSVTDVAHNEELAELVSAEDAFRTDYPIHRLARDGKLAEIEAWIAEKKGVDGDEGEGGTSSQLEWKGQYQQGGEWHDTSFKTKVLKVNGVYRFIGQDKDSAGGFSIKGTWSDNHIELEKEYEDGYCVSYEGDFDESTSQWKGYWSVSGLRDEFHFDVPVFDCPSCGRKASGVEGEECLECGGPDAGIDVTEEELDEMRAELVDGKAAVSNALNEKDSKGLTVFMHATMQCHLAVLKALLPFLSENDLAERDEEGRTALDIALGVQLVCAKNTERRSNNDLIEMIELLSAESKVKVEPWTIPQNEHMDVPSGDGDDNTCCGDCQLTDKKKGIELAKMAEGKQWEDLKLLLAQQLSADILNHADESGSMALHRVCEHGNAEVLELLLKQRHIDRYPQNSDGEYPLLVAKNNQRVKCVRVLLKDGAPPMKLRDEKTDEENNFNPVTLINTKFKADRLILERFHLQEKYPLFYEAKVENIQQAESCVDAKQTPLFAAVLGKQAINVVRLLVECNIDVDLQDIHGRTALMIAAKNGDVEIVNLLLQQEPLVDLIDENGESALFYAAKAGHVDVVESLLKALADLDLKNKDGRTPLDCVNVENKAAHAREDSVVTGHEKIRDMLLKEGETRESSLDYRKKLAKSLVGMEAQVAFEQNGFNKAVNCSPKLARSFLDDCVDMKRHDVGFDLKSLVSVYGKKGKDSVLYAMLNLKDSSGDEMQTEAKEECLDHVLMHRVLSIKWELFAQRKYSEQLFMNILLLVMMTVSSIIHGDEVAKKTPTVFDLTTIIGTFTFVFAIVGFATVQLLYPRTLWRLARFMHEGSLKFDPYYFVPHLKLHKQRAKRRLAFIALVLTVVLTAVALFLTWLFKLESSYRFFVSIVLGVTAVYFLWQEAKEMWTDEEYFESMFNIGQLFIYVTIFFVIVPVNVGIYSAPEEIRSGIGAFVTITLWILSVQYLEVVPSASFMLPMMANMMNDVKNFFIFFGVFQIGLTVSFYQLFRKSGDGAFISLPQSFITTYFVAFGNLPTDSLDSLVPEGEKMNSYQEFLYTVAVVMMMFQAAVVVIMLLNVLMAMMNNAVDGGLESAKTEALAKYAECILRLELALNLSEKQVKDSIYFVLPGEDPTEPMGKLNPLFYERCFKSELNMNEEQENKIQQHMDRKQAWADLMEKLETQTNAQLKKFEDKLNHVKHFTEMDVDHVFANEFAQIKDTRSQVSTIFERSRKAKGQDRDHVLDRLQNSLNKQFNKLEQDILRVWIANKDEAHKKCVLLFHLAFQRDMETETNTLKNTIKSELEESLKQAAKTMVDEPKLSELKRSVDDSQLAMTDKIQESSHQVTALVQEVKADVESNKYEMEQLQTKLDELMEMIRELKGGKEEEEEEEEQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XQX2</accession>
    <name>A0A6G0XQX2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_002221</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000023">
        <property type="protein sequence ID" value="KAF0742819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XQX2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010064"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013714">
        <property type="entry name" value="Golgi_TVP15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38894">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38894:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08507">
        <property type="entry name" value="COPI_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0742819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="23769" checksum="338D3A8B021DCC3D" modified="2020-08-12" version="1">MMPMETTIAPTSTKAATTNAVASAAEYGKLPPLNPDDLKLPPPPPSAASMARKDNDSMSLSEVWAEIKTKFHESVVGTSVSGILNVIRVCNFIMAGGMIAIAILEMINTKSFGSAISSIMAVVYTILFGLILIGYETRTKAGDDFLRANYGFLYNPWGRCLFLCMISIFPFGMFSPYGWMFSIFGFANAYFNYFVITKHPSFTSGVPDYEPPTVSTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XR29</accession>
    <name>A0A6G0XR29_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_002318</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000024">
        <property type="protein sequence ID" value="KAF0742775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XR29"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015389"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09279">
        <property type="entry name" value="RNase_HI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13456">
        <property type="entry name" value="RVT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="7"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="346"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="735"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="741"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0742775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="763" mass="86915" checksum="8E90789CE04104FB" modified="2020-08-12" version="1">MPTFTDQDEGYVAAFDGAIKVKERFGSWGAIIWKLPEWSIVWAGAGCCSDATVNVAEYEGAKAALRAAIQKNIKSIHVFGDSKLVIHQALEWMQCKQEHLQAQLRDLRALEQQLSSVEYHHILRQWNGSADHLASMGLTMRREVTELSATDLDDIREKNLLAELLQPLPDTKDLLDNEQPAKSILAYTHPKPTSRVVGLNSQIRLRRVSEAQDQERKWSNIKRFLREVDNLTPEECSKASKEAGMYEIGEEGALFRLNWSTKRCNLPIFIWTLVIPTELVQAILHHCHDSAEGGHFKFHNTYERLRKPFYWGGMYTDAKNYVTACETCASGGPPPTTQVRSPGNLIPQGPLELVNFDIATDLPRSFGGNTQLVVFVDNFTGFVMCKPTPDRSAHTLAKAFEETVFVRFGACREVRHDREPSFMGEVFTHFMKMIGQSPMPTFAYRPQANGTVERAIQTLVRSVKLYVTDPRQRDWDEYAVRLTFAINTTPSATRGDTPFYLMHGWDPFTTITASLPATKSGDHEANRWRSQLHQQHVFCKAMAHDLLCQAVKRRAEAHNAQLPPAVDERIKVGDLVWVYIDQVKSGVNKKLAHLWHGPFRVLDKKHDYASVLEIQGRLALRNHRFHAEVHDSRLKPRRVFQLRPTERMDSQPPVDFDEGLYLPPDSFEPDPDEPQVFGIRAVRYIDHIKEYEVQLEPDGAWTWVAAISLPASTLVYEFEHDRLHLDRLDMMVQTDFVPPNNDDDEEETKSEAGGGEEDDLPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XRE8</accession>
    <name>A0A6G0XRE8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein ARV</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_002180</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Regulates also the sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ARV1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000022">
        <property type="protein sequence ID" value="KAF0743123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XRE8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009963"/>
    <dbReference type="OrthoDB" id="2192830at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097036">
        <property type="term" value="P:regulation of plasma membrane sterol distribution"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007290">
        <property type="entry name" value="Arv1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14467">
        <property type="entry name" value="ARV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14467:SF0">
        <property type="entry name" value="PROTEIN ARV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04161">
        <property type="entry name" value="Arv1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0743123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="256" mass="29493" checksum="0A70DCD68238D0C3" modified="2020-08-12" version="1">MMTNDPSSKRLSCCCVECGTVVSSTYRDYGKGNIRLKICRNCNRTVDKYVEFEAILIMIDLMLGKQQAYRHLLHNRRPLLQTQQVLKMFAVMVMLDWNTKAYLAERDVGVYFRTNSIYKTTATFSIFQISQLGLHYFVLAVVENFVYMLTLWLCVRLHPRWRQGTTSKDVQFIGALCLSSFGKLFAWLTVIWEYHWTVVHVIGGIVVCSNYLVLKIYVNDDTFDVLMAVGVAVGIRALTQLLLFALGNPMIFFTFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XUX5</accession>
    <name>A0A6G0XUX5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Alpha-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_000949</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XUX5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010421"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031037">
        <property type="term" value="P:myosin II filament disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903013">
        <property type="term" value="P:response to differentiation-inducing factor 1"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16968">
        <property type="entry name" value="Alpha_kinase_MHCK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.200.10:FF:000002">
        <property type="entry name" value="Eukaryotic elongation factor 2 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.200.10">
        <property type="entry name" value="MHCK/EF2 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004166">
        <property type="entry name" value="a-kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051852">
        <property type="entry name" value="Alpha-type_PK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018649">
        <property type="entry name" value="SHOCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45992:SF2">
        <property type="entry name" value="EUKARYOTIC ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45992">
        <property type="entry name" value="EUKARYOTIC ELONGATION FACTOR 2 KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02816">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09851">
        <property type="entry name" value="SHOCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00811">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51158">
        <property type="entry name" value="ALPHA_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Alpha-type protein kinase" evidence="7">
        <location>
            <begin position="176"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0744473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="449" mass="50440" checksum="F00F8E15CBDEBF58" modified="2020-08-12" version="1">MDGNRVRSSSAHLHSVSGQHTAETHKAKMNTVPSDGPTTDGQDPGDIQAAPTPLSVHTPAAASLVESSNRSLDDTMVWSTCTPTEVAQSATIVESTEQNILSRISTLSVLRDQGFIDEEEFQRRKKAIIDELTFPSSNGNSTRRHNAFQMTNGLPLIIPHAPNFDGLDVEQAIRHTFNYETRRWETSQVCVILDETPFAKGSLRVVYHMREASQPNDETYVAKLAIDPDEDPQTYFRDIELQAHCAHYARLYNEYKPPKRIEFIQAWVLELTKRNGALCAVERYIPGDYRKHNNNFGSVSDEERNTPQAFSHFTYEASHHELLAVDIQGVGDLYTDPQIHTLNGHDFGKGNLGVLGFKKFLASHRCNSICTYLKLPPVNPKANSADQGTVPVQRLMNSDKIQAARFESKHYYEHAPMLKKYIAQCRDDEQTTKQTTNERSCAMCGCSIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XV06</accession>
    <name>A0A6G0XV06_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_000776</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XV06"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008973"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05123">
        <property type="entry name" value="STKc_AGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000048">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045270">
        <property type="entry name" value="STKc_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="54"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="8">
        <location>
            <begin position="310"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0744288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="376" mass="42593" checksum="E2DC5B7203D2D83A" modified="2020-08-12" version="1">MAQVSYNQLFEHLPPMPCPDGNASPMSDTDDMCRRRKGSLKRPLQSCDVEPADLEMLKVIGRGTFAQQVALAKDRQTSNVYAVKSCDKQNLVKRKQVVHTWTEKRILEKLRGHPFIVTLFSTFSTPDEVHFVLEYCPGGELFYHLHQQDRFDDVSVQFYAAEVLTALHSLHTANIVYRDLKPENVLLDAAGHIRLADFGFCKDIGDAERTFSFCGSPEYLSPEMIKRRGHTVATDMWSFGCFCYELAVGHPPFQMQNDALPALFESIQRGFVYFPPSLNPCFVAFVKGCLDVNPATRFTTAQAMDHPFFKDIAWSDVLARHLKPPFIPPVDGIESTQNFDDDFTSESPRSPTLLDMKHKRLAQDAPSPEVDVFVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XV10</accession>
    <name>A0A6G0XV10_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RING-type E3 ubiquitin transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_000810</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XV10"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018834"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16521">
        <property type="entry name" value="RING-HC_MKRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045072">
        <property type="entry name" value="MKRN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041367">
        <property type="entry name" value="Znf-CCCH_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11224:SF10">
        <property type="entry name" value="IP09428P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11224">
        <property type="entry name" value="MAKORIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18044">
        <property type="entry name" value="zf-CCCH_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14634">
        <property type="entry name" value="zf-RING_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="9">
        <location>
            <begin position="3"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="9">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="9">
        <location>
            <begin position="239"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="287"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="9">
        <location>
            <begin position="361"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="3"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="239"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="361"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="64"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="106"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0744322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="400" mass="45228" checksum="CB932F0E2641EDB5" modified="2020-08-12" version="1">MSFETKKICTFFLQNQCTKGTACRFEHTIVATTPRRPPCKFFLENKCTLGSNCRFEHKVRTNSYSDEGSFPQMSSSSNPSLLSSSQTPGNVRPAKLPVDQRTATHSDNSQPKSNSSQPKSDPNRIVKGEINGLTFQVEIVDPSSIFALAPRRDIDEETDYSYVEPEPMITAMASPDSPRTDSEITIKGKKSDAITSKYTQQLDELEMRVKELQVDDLDGHEEQFGNTSDYSEYSDVQPAHPPKICKFYQQGNCRYGKACIYSHSIPIDPNEERLMQQELLDSQAVECNICMDLVLRQGERFGLLSDCDHAFCLKCVRNKVNKETIRNCPVCQADIAFVVPSNRYVQDPKRRAQVIAEYKRNVAQIPCRHFALGRGTCPFGTACFYEHRYADGSLQERDCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XVE1</accession>
    <name>A0A6G0XVE1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_001097</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XVE1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001607"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033562">
        <property type="entry name" value="PLPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12406">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2 IPLA2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12406:SF7">
        <property type="entry name" value="PATATIN-LIKE PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="3">
        <location>
            <begin position="3"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="36"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="158"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0744633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="240" mass="26808" checksum="0E8E05ADC0F6FC9C" modified="2020-08-12" version="1">MNLSFSGSGFLLAFHIGVANYFRRQGYISAKSRFAGASGGSLVAASLAYDVPMANVLDETKNTARSIHEDLKKKKMFNLSSYVNKHIGALFPEDLPIHDFPRLVIATTQVWPRVRTVHWTDFPNKDFLADRMLLSCHVPWYFDGTPARRIDGKEWHADGGLLCFVPEVEDHVKVSIIPMPWDRKTISPALIPNFPISSARLLQWALLPPSNEMLDKIVSLGEEAAEIWDVSRSQGDSVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XVI2</accession>
    <name>A0A6G0XVI2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_000945</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC43A transporter (TC 2.A.1.44) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XVI2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010417"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052599">
        <property type="entry name" value="SLC43A_AATransporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772">
        <property type="entry name" value="PROTEIN FMP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772:SF2">
        <property type="entry name" value="PROTEIN FMP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="411"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0744468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="511" mass="56409" checksum="CE07D0D4E20FDFA4" modified="2020-08-12" version="1">MKGQPVRPLAVALVVVVLVTDILYAGLIFGWAPMLLLLQEENQYGELCLIPDERCADQDSRLNMIYTIASVAVNISSLPVGCILDYFGPKYSIILAAMLEISGLFLMGAADSMTFDVFLPAYTLCAVGGCITMMASYPSSFLIMSHQTAILAAISCLFDSSSVMLLVMYGAHASFGFTRQDLFFGFGFISIGVYALLVVLWHFNENFLPDQVDSTASTDMTFNSPLLQPRARRNSMRESVEQYGSLSEEALLDHRDTTAVVELYKTGQADNELATFSLGKQVRTFEFAFLLVYSSIHVLRANLYIGTNNKLLENYGDASRDYLYTKIFSFILPLGFLFVPFIDFFVEKKGLAVSLHIATGLGVLFNVLAMVPILSLQSVVFILFTGFRAFLYAAISAFAAKIFGLANLGKIVGLTFSCGSIVSLLQIPAVVYSNAVGSLDLVYTISILLCLALVPLTEWYRRRAERRIRHHSKVWKALGESSSSMKGLQYRRSPCLPSPAAARRSFVEHQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XVP4</accession>
    <name>A0A6G0XVP4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_001034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XVP4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004395"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0744562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="145" mass="15984" checksum="EF321BC120795C3F" modified="2020-08-12" version="1">MQSNDQEEDPAFAKKSKKDTSISPADSDTDCSSEISDWDFWGDESAFSNVDQVVHVRSDMGLVVSDYLCPCGECPLYPIIEERVMKCCVPPSSKGALCQILQAFSTYNEVVGFQPSMIPKAQRCLSQHKGDIDAAFQSFIALVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XVQ3</accession>
    <name>A0A6G0XVQ3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methyltransferase</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_001208</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4 5 6">Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XVQ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002220"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003838">
        <property type="term" value="F:sterol 24-C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050447">
        <property type="entry name" value="Erg6_SMT_methyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030384">
        <property type="entry name" value="MeTrfase_SMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013705">
        <property type="entry name" value="Sterol_MeTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068:SF1">
        <property type="entry name" value="HYPOTHETICAL LOC100005854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068">
        <property type="entry name" value="ZGC:194242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08498">
        <property type="entry name" value="Sterol_MT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51685">
        <property type="entry name" value="SAM_MT_ERG6_SMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="SAM-dependent methyltransferase Erg6/SMT-type" evidence="8">
        <location>
            <begin position="236"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0744753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="531" mass="58485" checksum="53307435DBD3F85C" modified="2020-08-12" version="1">MLDGLKLFLEQNKEGVAPAAGSAVGLFAVALLLHSKAALNMFVPSSSFPIGQVFNWASAAVYLLTTARVSALHRQPPAVYDVNVLLVWFASLSLLLVSFSVSAIRAETKAIFYSVAASATTLVAASVYVVQIENSTVTKGAIAAALVIFASAVFQTAKIVGNSKVSRDGSDFTTTLLGSTRLLSNPDSVLSRDAVNSRFEDYDKLFKGAREKTGAISSEESIKLRQSEYQLMVDSFYDLVTDFYEYGWGQSFHFANRFRDETFRESIRRVEYFLASKLGLNKSHYALDMGCGIGGPMRNIARFSGAKIKGLTINEYQVRVANKNNEKMGLDKQCHVQQGNFMEMPFEANTFDAIYAIESVCHAPDKKGCFAEACRVLKPGGTFVGLDWAVLNDYDPNNLRHVELKEGIEVGNGLPTLETPAQIAKALQDAGLEVVEHFSLQDNYRDPNEIPWYDTLSGRYTLSGFRMTWFGRQCTHLLVTTLEALKIAPKGTVKVSLMLNKTANDIVEAGKSNIFTPSYFFMARKPIKAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XW48</accession>
    <name>A0A6G0XW48_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_000528</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000003">
        <property type="protein sequence ID" value="KAF0744941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XW48"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017618"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016929">
        <property type="term" value="F:deSUMOylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080090">
        <property type="term" value="P:regulation of primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.395.10:FF:000001">
        <property type="entry name" value="Sentrin-specific protease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606">
        <property type="entry name" value="SENTRIN/SUMO-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606:SF1">
        <property type="entry name" value="UBIQUITIN-LIKE-SPECIFIC PROTEASE 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="6">
        <location>
            <begin position="238"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0744941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="442" mass="52433" checksum="CFB0139F1A003782" modified="2020-08-12" version="1">MEISRKDAEKWRLERRIEQAIRSSEEVMKNLDLVSTKPLWTKSTMSRREYRKQLHSALPSEYKSEQSRVKRLKGIDQTPDDPFGVQSVKRNNAELLKKLAAQMNQLSNRKKGPWKRSKSSEKPESRTYHQFLDSELENYHDKWNESSSRIQNIEDELEKYRVIRESRDIQRQHAAWVANRQWELLANDLVREELDDIIEELLDEEDEGPELPPEDESVVDHALHGGAMGEVLLQKFNVDVTRNLLQSLQPTTWLNDEIVNFWFQMLAERDASLKRPLKSHFFNSFFFSKVSEGGYNYINVRRWTRKIDLFSMDKIFVPVNVRNVHWCLAVIFMKEKRIQYFDSMNGAGTQCLEVLFKYLHDEMQNKKNTQFDETDWELVSSTEDTPQQNNAHDCGVFTCMFADYLSRDLALTFSQRDMKFFRKRMILRMVEGEIPVEEDFDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XWK5</accession>
    <name>A0A6G0XWK5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RxLR effector protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_000745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000008">
        <property type="protein sequence ID" value="KAF0744839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XWK5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004497"/>
    <dbReference type="OrthoDB" id="10314479at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026125716" description="RxLR effector protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0744839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="99" mass="11143" checksum="E62D9DD4F0DAFE12" modified="2020-08-12" version="1">MTTTCLAVIATTFLLAMGDDSILPNTVRAESPHEAIKSQDIAEMIGAKEYDPTERYYSPSRQTQPYSDYGGIADDHDEYYDGPHGYEGNGNFGRYRNYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XWV9</accession>
    <name>A0A6G0XWV9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4833 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_000256</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XWV9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001072"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032269">
        <property type="entry name" value="DUF4833"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16117">
        <property type="entry name" value="DUF4833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4833" evidence="3">
        <location>
            <begin position="164"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="25"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0745223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="309" mass="34530" checksum="E2D6465EB6C99321" modified="2020-08-12" version="1">MSWIWGNDVTVEQANMVVMSLQGELDERQATIEALVKALQKEKKDYRDALVEEVHELRERKQALQKELDQIDALIAIKTEQINSGEKVKAKKTVAAPASTPTPAESTSTTESAPADEKKEKKKKKSRKSEESQTQEPDPEGALTTLPSNSELVKVRSVDANTAFIIQRSNNANTVVYKGNILSNNTLDSNSPLHVYWIMYALPGPPFPTEELNVIERNTAYGATATARPGTSNEYDVVLASLKDRSIVLFVDDRHNVRARTTINSRANVYLERVYVQSTTSWGLPKVEFIEIFGVDPATHEEVYEKKIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W452</accession>
    <name>A0A6G0W452_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_018815</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000358">
        <property type="protein sequence ID" value="KAF0721912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W452"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016391"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15745">
        <property type="entry name" value="FYVE_RUFY4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43102:SF2">
        <property type="entry name" value="GAF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43102">
        <property type="entry name" value="SLR1143 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="5">
        <location>
            <begin position="318"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0721912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="580" mass="64415" checksum="EFCB1A24D647D912" modified="2020-08-12" version="1">MMNSAHMVNNQRFNMRTAQTAAPVKWPWAYTEENVLKLLDDTLCQRATGFAEFMDSSIVDLNEEQYLQRLETGKVDTSRTKVDSKAHVHTVHASTLVPATLTEVLTLFDDANGPSDQLTARTFRSLLISNLELRRIVSSFQPFAARQSRHTFARCNSDDAKSTVSSNVSTGSPSHRTILSFALKKAVFQESRGPFSKSPQRELFYLDIFEQLSPSTICRTIKSVDLLSESPTFTKGELPLERHQHVLMSYHIEAVGPTRVRMSFAGHYCYQHGMVEETKRMVAKFAEAVEVLPRLVFQTRLAAVLFSESKMNNKQKHTATGNACRLCARTFSAFMKQRLCRLCGQDICSSCSTVEQVPTTNDLTIDARICHTCVETLKEGDFNPRQESSLTVLLSNTMQKALASPAASIGVRKLEAPALPTTSARRKNKAAASATRQTIVDDKRHDTLYDVTCMTAARRMGCDTACVTLVDETGNLVIKTKHGKGVDTVLVRETIHKKAACIVKDAAKDGRFSDPQRPSARFFYGLPLVLEDGLSVGVVSVSDGTPRAEVDEFHDTIMHDFHQTILRLVETARKPPTSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W691</accession>
    <name>A0A6G0W691_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADH:ubiquinone oxidoreductase intermediate-associated protein 30 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_018333</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CIA30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000330">
        <property type="protein sequence ID" value="KAF0722600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W691"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017151"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013857">
        <property type="entry name" value="NADH-UbQ_OxRdtase-assoc_prot30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039131">
        <property type="entry name" value="NDUFAF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194">
        <property type="entry name" value="COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194:SF18">
        <property type="entry name" value="COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08547">
        <property type="entry name" value="CIA30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase intermediate-associated protein 30" evidence="6">
        <location>
            <begin position="39"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0722600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="263" mass="29315" checksum="057A8190E5809AA0" modified="2020-08-12" version="1">MAKRVSFLRKVAASAESAIISTKQMFGMKIEIPKEAAIFQFNDPTSTEGWLVSSDRAIGGQSTCSFKHEPAQNSDDPEGGSAVFSGTLSLSLQPTEQFVVRSGYCAIRGKVPRHIMLHGYEGLAMRIKTDGRVYRINAQADGWNPHDLYMGFLKAPPNEWVESELKFSDFILTSRGYAQVDDPNKLNPAKLATIGIALADEKEGDFHFAIDWIKAVEKVETTNLYPKPTVTIKEDTEVHEDEVKEVEETKPVPKRPRNPDLMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W6Q3</accession>
    <name>A0A6G0W6Q3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_018198</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000326">
        <property type="protein sequence ID" value="KAF0722719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W6Q3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005900"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="3">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0722719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="517" mass="58003" checksum="CF18E6F3543468ED" modified="2020-08-12" version="1">MDLIQFLGAFPVATAAAVLVMAGATTMLYYFVHEPATNPLNALPGPKSSHWFFGSLKEIMDVKWRDGHFPEPMLSWVKKYGGAVHYRATLAHRVLLTDPEAIKHVFVANSNNYPRASEARDFSRILLGGDGLLSTEGEPHQHQRKMLMPHFGFAKVREFIGIFARHARQLSMHYHQVADQGVAVDMHDFFTKMTLDVIGVAAFGYNFGSLENANDRVLDAYKMSSQLPDLFYALGSLYIPGFDKWPLPRLVKQREAKRILLEKVESVIAAKLQAPRDVSRPVDLVDLMLDVEAESEHKVTPEDARTHVMMFTTSSTLCWVFAMFATHPAMETIARKECQAIAAASEGGEIGWKSLAELKYTTAFIQETIRMYPTATNIAHRVCAADDHVPMSDGKPFFMPKGSTVILRLGALHRNPKYWSQPDEFLPERFLEGTAVYEADKELRNGHGNTFTYMPFGTGPKTCIGMRFAMAELQTVVSNMLLQFSFRLTDKANINPLMSVTIRPVDLSMTIHSIAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W713</accession>
    <name>A0A6G0W713_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleotide-diphospho-sugar transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_018567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000340">
        <property type="protein sequence ID" value="KAF0722275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W713"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001581"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044845">
        <property type="entry name" value="HPAT/SRGT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31485">
        <property type="entry name" value="PEPTIDYL SERINE ALPHA-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31485:SF7">
        <property type="entry name" value="PEPTIDYL SERINE ALPHA-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026346714" description="Nucleotide-diphospho-sugar transferase domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0722275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="484" mass="54311" checksum="E2E22CD18A4D00AC" modified="2020-08-12" version="1">MQQSGPAWIISALLCLVLLGYAAFNVEMKMVSHLTPSIASIEPSHALRTSKQQNEKPTLNYAVDPKHNVHLVSTDSCEQDLRQLMSAALQLSLVRVGHKGPLTEIITGCTTAQKEAIAKLPTFYADYRVHFTPDFAWQTLDNGVRQHYYPYNKPFGLAHFLQHGQPKDDLAVALIDIDYFLLQPLEVNRGANWTRFYQVSSQSLRDPSTITDTVSKGIAIAQNMKAFLGGVWWNDRNSTVKDIVCKDKPCALVSNDEAMEYFEPSGTPYILTRSDMERVVVDYAEFTRKGRTLEDKWMVEMSAWGAAVANQNVKQTLVTHLGGATCAYKDTEYWDFLPNDIANPCEDDETMVLPRDGPVGIHYAMYYGGDQDPVKSGFAFYKYRIPKDITDCNSMLLAVPPPSEWTKATEKAARHGVWLECTAIKLLNHALLAIKRRTCLQGFNSFRGLMLRADINYMTGFPTEGNMDLFHNVQRSMTSAAPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W739</accession>
    <name>A0A6G0W739_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_017928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000317">
        <property type="protein sequence ID" value="KAF0723057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W739"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0723057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="226" mass="25449" checksum="95CB697F0E51BC0E" modified="2020-08-12" version="1">MDGGDAEAGDNMQRCRCIEAVIDLDIVRGVSQSPLHWRIGGIRLADNIAGDFPRLAQIGSIDLRISLSPRRYGMESVWNKEARHEGHYHARVPSLQHGHTVFSVDLFKLTARLLQRLGAFFSQAATEFSGYAFVSFQLMPTKSQSHQTMPFESQIQICQANSSRSMGLTPSKEIKRTRSSYRRRPARAPSRQPSHFMLAQFNFNVSRQPSTANRSASSRRIRSNPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W834</accession>
    <name>A0A6G0W834_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA polymerase II subunit A C-terminal domain phosphatase SSU72</fullName>
            <shortName evidence="9">CTD phosphatase SSU72</shortName>
            <ecNumber evidence="9">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_018268</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SSU72 phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="9"/>
    <dbReference type="EMBL" id="VJMJ01000327">
        <property type="protein sequence ID" value="KAF0722669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W834"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018199"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006811">
        <property type="entry name" value="RNA_pol_II_suA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20383">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04722">
        <property type="entry name" value="Ssu72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 9" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU369031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0722669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="158" mass="18564" checksum="DE561ECF7EAE213D" modified="2020-08-12" version="1">MVRFPGPNPYEPRIFPFFTPYEVMYRELKSENETLFRRNGVLAMLERDIITKKAPQKWQDNTIDDLYKLDVVLCFEDRIFDIVMEDLQLRKPKDLRPLHVLCLDIKDTPKDAKIGGSLALDLCQLINQLPDLENGVPQAIETFETQKQIKLLYALFYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W9B5</accession>
    <name>A0A6G0W9B5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycine zipper domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_018179</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000325">
        <property type="protein sequence ID" value="KAF0722766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W9B5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006045"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026161971" description="Glycine zipper domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0722766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="18192" checksum="B7D50E6C1CCCD3EC" modified="2020-08-12" version="1">MRLLVTLSFATCAVVAVNGPRQDSPVALAHPQASAAYNLRALKVDSFDTPSRQLAGKEGGRHMGRSEIKGRKIGGRVGGVAGAVGGGALGGAGGVVAGAALGSTGLPIGTVAGGVAGGMAGAYFGGSVGMLTGKKAGESLGGKIGRQFDKRRDKKNLKNFEAANPQNPARLTRRHSGKFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WDK0</accession>
    <name>A0A6G0WDK0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nucleolar pre-ribosomal-associated protein 1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_016142</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000243">
        <property type="protein sequence ID" value="KAF0725371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016118"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039844">
        <property type="entry name" value="URB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032436">
        <property type="entry name" value="URB1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021714">
        <property type="entry name" value="URB1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13500:SF0">
        <property type="entry name" value="NUCLEOLAR PRE-RIBOSOMAL-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13500">
        <property type="entry name" value="NUCLEOLAR PRERIBOSOMAL-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16201">
        <property type="entry name" value="NopRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11707">
        <property type="entry name" value="Npa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="URB1 N-terminal" evidence="2">
        <location>
            <begin position="108"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="URB1 C-terminal" evidence="3">
        <location>
            <begin position="1457"/>
            <end position="1650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0725371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1830" mass="204752" checksum="60B02DEFBC58625D" modified="2020-08-12" version="1">MVKKRHGMNETDKAAKRPKSDASPAPAQPQSQPQAQAPPVASNAVLRNLLLNVQKGQLDPVVTTLREFLTAVSPETTSCSLLRAYLEISPQSEPLIDLWGSTLWTEDKSRQIIPITMELLQRVMEYLSHHTPSVAETVAMNLLKTKMEHIAKQLSWSDKPYIVYSTLALCTTMLRIHARVAREFVRLFDFTAKSFEALCARRSRDFDVPETTRQINVRQAFITFALALTTSPDPHVRRFAVKADGIATGLFKCIEDDTFDNASLILSTLTSSILTSDGIRTKHNVFSTTAISHLIKLLDSSDEKSVQLAQDFFDTLFFSPTSLYFLSQEATITEPSASNESHDAAFKVVSKIVSSFDLMSTMTHPAREALLFRFLRAFPALILVVFQSFHAVMDPRPSYKWFSAASFVLKALHVSLTPLKDMRWTSQHHDLLVKLVLPLGLQKKELSKAVQHTNLLVVHTSLNLVSVVLRRFAFLKLCVDDNNGDAVGLEKDVRTLLPPPELILTLCTKLRPAAGGGDSKQAMIYAKALSVLQLYFEHLPAVMSEVKFDISKLIGVETNVLLQGSLLGLLEHVDSSRLGWIVSGDATKFRILLGYCTSSQSAIAVLGHRVVRRVLACLHIFGLTKPDAQAPHEIDAWLLHLKSGEAATFFDQLVRGVTANPFAFVYDSSMSPMTRALVAYFESTSDNNSFPFSISVNEPTVVQAFGVRVLSSLVSILPSLKLSDTSKLPNELIFANFLKTTSSLSSKKQVTSTSKPTKVSSVKDCVKHIVRLEAADFTLSSELLAAVYKTSQSFDPLYVYFDTYKTKSIFESKVIRQAIEHPDKAEPIVRQFVQMAPLHVVLTSLFSPFVWLSHSSGPSIQPKHLLAYLSKIKLNIQSVQLTCLSLTFGLRIYQTRRQQGFVPDAKYTEAMVHSVKALHFLLTWALGKSSDAFWSMIWQHHAELLANLYENDDVLTQWLVLPYALSSFLPKSSLDVLQVKSNSPLQVVMARHASSSQVHGALSSMLTTKFVCSPLVVHLLSYCIEEPMDDPELFNAVFQFWKHHPHESNAKQWLASAIQKYSMASPTIAQELFQLIWETNSTDPLDILVLQQLIRRSSICREDFASGQRKTHSLSSVMQLSAAYLTSLPLEPTCVSWIETMVVPSCIEEMISTEEASDSMATLVQVVDCLYSQEGKVLPCSDWIPELLQQKRGVHAAKLQLLLLAAHRSDLSRFASKCVGFILSILSHHDGFSSDSSTLDALAFVLLDVLQRYNPKKIPTSAVESLVKHLNSHSDWTHRSSMLDVVSTLADTFSSVDFSSLLQQVLDNFDTLVDVGSFLKTLGVLLEKETSVDIDVDFQKQVLGQYGATLSAKDLHLKAILEVLETRGLSLDQVGYCFGKANQTATTDMVQHWLLEEIDNHTMRRSIELFPHTRPFTGTFPPEENVVYDPAFFMPLIAHAVSSSHIPDRQLLQSGILGYAICGLSTEDEKIRAYAYGIVAVAHEAMSATARTFEFNERRQVHLLLETLKNGITEPHERVPFLITVFANDAISALMKPGHFMYPLVNAFLLSRSALDVNDVPMFYALFNSSASTFRAERSWLLHLVKRGVKLDCDVELLQRRHVYSILLGFFDSPLADTQSQELVLDILSSSIATASGMFLLVHKMGLLAWLEFVAIKYKTQYLRQILAMSITALQNYHLPEKQNDRYLPNTLTQLRQLGQTLVSITTDEHTDLLRSLFIEYFEFCSTKPHVAISMWFSLDLLETTVKLVALLEDNKTLLSHTVSFLARIATASRDLQFNKATYDRWAAIAAWAVEQVPLTNYLELKLALPQTIQHLTKEVPAFRECLKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WDP8</accession>
    <name>A0A6G0WDP8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycerol-3-phosphate dehydrogenase [NAD(+)]</fullName>
            <ecNumber evidence="9">1.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_016079</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 9">
            <text>sn-glycerol 3-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.8" evidence="9"/>
    <dbReference type="EMBL" id="VJMJ01000242">
        <property type="protein sequence ID" value="KAF0725438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WDP8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002427"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141152">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000019">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(P)+]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00394">
        <property type="entry name" value="NAD_Glyc3P_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000940">
        <property type="entry name" value="PRK00094.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000942">
        <property type="entry name" value="PRK00094.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728:SF1">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE [NAD(+)] 2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000114">
        <property type="entry name" value="Glycerol-3-P_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0520">NAD</keyword>
    <keyword evidence="2 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal" evidence="10">
        <location>
            <begin position="22"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal" evidence="11">
        <location>
            <begin position="198"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="27"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="273"/>
            <end position="274"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0725438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="349" mass="37267" checksum="0C9F6968CF94D9A7" modified="2020-08-12" version="1">MVGTIASSANADLPSTNVEQVKVGVIGAGNFGTAMAQIAARQGHQVVLYARNQSHVDTINLTHHNPQIFSDFELLPNIHATTSVKEACAGATLLIMAIPAQTTPTFLEEHRDVIPEDAILVVTSKGLYLKTKQLLSVPILAALGRDQPLSFLSGPSFALELMKNQPSAVVVAARELYHAVRVQRLLSTVDFRIYSSQDIIGVQLGGALKNPLAIGAGMIEGSGLGINSLAAYVTRSSLELQKLCTAMGGHPQTISGLSGIGDLMLTAFGSLSRNRTCGVRLVKGEKLQDIMKDATVEGVPTAEVAVYFADKCGLELPIFRVVNDYIQGRVTSSEEIHNILMNRPLKAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WE93</accession>
    <name>A0A6G0WE93_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_015892</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000235">
        <property type="protein sequence ID" value="KAF0725673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WE93"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005367"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="5">
        <location>
            <begin position="277"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0725673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="443" mass="50604" checksum="7230384EA7B61F65" modified="2020-08-12" version="1">MALVPPPRKSSMLSEASRVIRPEDRAFYPLPESAFHLPPLSALEIDSFVATASRSFDVLFNRCVSTELLWPPTSQAHSVHLVYGNSITARSASVFACAKIYATLADIVALKDRTESIQHVAEDVLDSKILYEVVDTPRESIYVRWEALAFNLPLLHRDVCVVEAQREFDYVNGRRGWGFAQHSVNLDGCRELQEPPYNLVRGTMYHSGMLALESGVHGLLDVYCQLEIDLKGLVPIWLTKMQVAKRAKRHLKALSTCIHEKRLTERIQFQFVVLVPKEERTHCSRCTKAFNAWRRKCYCRVCGEVFCWSCTQFWRVEQRPRRVCLLCAGVYQAPAGQYYHDPLLNSNLQALISNGDVAVVPRRQRASTSVTTRSASLFGRRKLGMTYFEEKRSTEMLSDMDHFETVPSTEAIFGDDNRPPMLEALDSNRQTRGRRAKSEFYVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WET5</accession>
    <name>A0A6G0WET5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine-threonine/tyrosine-protein kinase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_015737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000231">
        <property type="protein sequence ID" value="KAF0725886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WET5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005891"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0725886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="87" mass="9880" checksum="1FE711A0EDFE4FF9" modified="2020-08-12" version="1">MSELDTHSIPYHDIRNPTNSEPISDHALIGKVLAGEVTPTFTDNCPRWFLDMAKQCLRHNPLERPTAMQISHIVRGYSNQFEEGGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WEZ2</accession>
    <name>A0A6G0WEZ2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytoplasmic dynein 2 light intermediate chain 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Ae201684_015923</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Cilium axoneme</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dynein light intermediate chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000237">
        <property type="protein sequence ID" value="KAF0725590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WEZ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005629"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035735">
        <property type="term" value="P:intraciliary transport involved in cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040045">
        <property type="entry name" value="DYNC2LI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022780">
        <property type="entry name" value="Dynein_light_int_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13236:SF0">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 2 LIGHT INTERMEDIATE CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13236">
        <property type="entry name" value="DYNEIN 2 LIGHT INTERMEDIATE CHAIN, ISOFORM 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05783">
        <property type="entry name" value="DLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0966">Cell projection</keyword>
    <keyword evidence="11" id="KW-0969">Cilium</keyword>
    <keyword evidence="9" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="10" id="KW-0243">Dynein</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-0505">Motor protein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="10"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="291"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="302"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF0725590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="341" mass="37894" checksum="E1DFE2BA1E887224" modified="2020-08-12" version="1">MESKDIFARLAAAEDKSSQQGETGDKDDSFLVVVGPKNSGKTSLVMYFLNPNKLDEPKPTAALDYVYARRAVPGSNRKAVAHIWELASSKKVLDLLKVPLSPERLPKSALMLVLDLSAPGEVVPSLVYWVNLIRKLLADTPSGFTTEQALAKYGSTHPDRREVSPIPLPLLIVGSKYDTFRDEDSVKRKGLVQAVRYIAHSIGATVVFTSVKDKALATQFRATLSAAVYSTEAKTTKEVEKGLFIPAGTDTFEEIGLPKGARPADLEDANWDKRMRLWTKAAAELYASNVKETADEEEKDEAEDKFPEPTIDALRKQKREELRRYKEKKTEKKPAKKEAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WF65</accession>
    <name>A0A6G0WF65_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cellulose 1,4-beta-cellobiosidase (non-reducing end)</fullName>
            <ecNumber evidence="3">3.2.1.91</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_015528</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains.</text>
            <dbReference type="EC" id="3.2.1.91"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 7 (cellulase C) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.91" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000223">
        <property type="protein sequence ID" value="KAF0726196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WF65"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006949"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016162">
        <property type="term" value="F:cellulose 1,4-beta-cellobiosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.100.10">
        <property type="entry name" value="Glycoside hydrolase, family 7, domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001722">
        <property type="entry name" value="Glyco_hydro_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037019">
        <property type="entry name" value="Glyco_hydro_7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753">
        <property type="entry name" value="1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753:SF2">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00840">
        <property type="entry name" value="Glyco_hydro_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00734">
        <property type="entry name" value="GLHYDRLASE7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="78"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="87"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0726196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="164" mass="16094" checksum="627AD913E5F61951" modified="2020-08-12" version="1">MGAEGCGVVQKGVVLTMSLWVDYAANCLWLDSTYPVNKSPSVPGAGRGTWATTSGVPADVLAQSGSATVMYGNIKVGDLGTTTGGVKPPSSGTTKAPSAAPTKVPSVAPTTKTPSAPSTKTPTSAPTKVPTKAPTTAPTTHPPTAPTKAPVTSAPSSGGSVAAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WF75</accession>
    <name>A0A6G0WF75_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_015895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000235">
        <property type="protein sequence ID" value="KAF0725676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WF75"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005364"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0725676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="305" mass="34640" checksum="D7DD43E82D0ED709" modified="2020-08-12" version="1">MGGEGQINAALGRVCSLTFPQATGITRVLLDANYVCAVGMKLFPQLFATLLPAKTTEYVLCRLVDDAVVWVEDDEALLEIFHDEGNQCETLHAVISNKVQGMQAVVRSHMSPEFSPELDYLPMQTPDETKAEAETQIHTEEERDEDNANLNGMLSLSHFEEPQQQNEAKAEPINLFDSIRLFFDQPKKKESDKKKESGKNWWSASTQFLMKPFTEKAKKEEEIAPTPIPDMTYRHSEPVRPLSASYQVLYPRMSYVHDEEAETAPRHNFHISSSWHQQADRMSASLRVSAKEKEKNSTMGSFVWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WH37</accession>
    <name>A0A6G0WH37_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_015340</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000216">
        <property type="protein sequence ID" value="KAF0726452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WH37"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020259"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="3">
        <location>
            <begin position="19"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="3">
        <location>
            <begin position="132"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0726452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="340" mass="37885" checksum="58E0C0680CAE935C" modified="2020-08-12" version="1">MGIDRRPSNIQSGDEFWIDVQKKAFTRWANSHLKELPITDLYQDLSDGLRLIALLDELSEHRFTAKYNKEPRYRIHKLENLNLVFGFLAKEHVLVTNIGSSDILDGNSKLILGLMWTIIKRYQVADIAVDGVSGKDGLLLWCNQILEPYELHVSNFTTHWSNGLAFCYLLHAYNATLVNLQDLSPDHGPDNLALAFSLLETHLAIPSLLSPEDLQGKVDEKSVLTYVSMVFQAITKPEKKSTEVPAAKPVEATADEETTAIEDATQLAPIQEESSLWTSIQTYEKAEERSPPLIQSLVSTPAATTTSLPPTKETPVSFAALSPVLTLLYPVRAFKLGKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WHF4</accession>
    <name>A0A6G0WHF4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAC3/GANP/THP3 conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_015218</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000213">
        <property type="protein sequence ID" value="KAF0726596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004101"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070390">
        <property type="term" value="C:transcription export complex 2"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045107">
        <property type="entry name" value="SAC3/GANP/THP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005062">
        <property type="entry name" value="SAC3/GANP/THP3_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436">
        <property type="entry name" value="80 KDA MCM3-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436:SF3">
        <property type="entry name" value="GERMINAL-CENTER ASSOCIATED NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03399">
        <property type="entry name" value="SAC3_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC3/GANP/THP3 conserved" evidence="2">
        <location>
            <begin position="506"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="874"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="962"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1537"/>
            <end position="1572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="353"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="461"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="874"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="923"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="962"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1010"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1547"/>
            <end position="1565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0726596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1609" mass="174475" checksum="6B06CEDB6270D1A7" modified="2020-08-12" version="1">MNAAGSGGAAPPFGGGFSSSFGSTSIPSSSGFGMSSSAPFGQSTGGLGSTTFGSSSTTPAFGKSTTFGSGPSTSFGGGSLGSTSTSTTFGATNPAPFGATSTTFGSTSTPAFGAASFGGSTMPPAPPPSFGSSSSNTAPFGATTSTFGATTAFGASTQPSSTPFSSAPTTFGSSSLIPSAPSTTFGSTVSSSSTSTFGSAAVPSNTTFGSSAPSTTFGSSAPSTTFGASTSTTFGLGSSTASTTFGSSAPSTTFGGSGSSTTFGASGSTPAFGSSAPPTTFGSSAASTTFGSSAPTTTFGSSAPTTTFGSSAPTTSFGSSVPLATLGDKAGKPPVFGASTLNTSAPTTTFGPSGAAPSTTFGSSGTTFGKSSTAASGKTVFGSSSSAPASGDSVTSFGSAATTFGSSNNASFGKARATSEKSQSSGPPEKTSFGGKGSQSEGTGSKLERKQPPRRLPPKPLQESSMPMSSPEPSPTSQGSSLLQESELEKADLSNAVNIDGLCIDMCSPKEREEQIRFDDLSTFEKGKPEEAFIIKRFQRAAASHKLDIPSEIRPLGVLRKTQLHLEQNIVDLDKKGIDNRFNPPRVPDFLDLYQFFWNRARMIRNDFTLQNYRGGGRHHAIAMDVHERIARFFILCEHELIENPNFVEQQNMEQLGKTMKSLQDFYDDARLRGDETSPFEPEFAGYFILLHLDKDKAADVLKYSKRLPPDVMAHHFVQFAMDAFVARHTNDYVTFFRLVQQATFLQSCLLHRYFPTVRSDALECMNRVYRQPYPLDLLTDLLCFEDVDQAAQICQHHNLPVDGHAVVFGSDAFETDVELRMANQRIPVMCSYRYVFAKQQDWLRRDVCRGATEYEEEDYPLLSRQILLEETRERERLYPDRPPYEDPFSNFESADGSANKRAPKPVFQQPKVIKPLEKVPRSPAQVPAASSSSPLKILSDIELQQQKIAQAKAELLKQIAEKEKLKSTKPAEKPVDTESPGKDIKVEDEQEKAAAESAKRAAELAAQEAARKKAEEEAAKKRLQEQNERLEAEKKKKEEEERERKQRLEEIERKKKEAIERQKRDELERKRKLEEEARVEAQKKRDEELKKQEIVKFGATWIRINFEEHENVNARKEAFDSAERAKEKAEQAYAIKKLRFALWRRYVLRQQQPRQPANAEFVAEGASHHTNHSTKPMLPSALCSVARIIPQWTVLDAEVTLRAQSTWVELQDHLFSPLDLSIAAKGLCARYPTTSVLTYSIGLVSLAQDRASDWLLAKCGIENDFSTHRVAMGLQTVVFDFYKDQFTKVHCLWCPLIARHVQEIDAFVAQLAAKLASVDHRIDLHFICLTTNVTDQQIRSSTKAFPDNVHIASIQTCDWDKAANAIDALLAIMSRHAVLFPVSLVNLREIIDDVVHLTLYQCSNEASTLADVAMHVQEALETLEHLVRATDSSAVPLLQSLNQQIPLPLKECGQSSVAWLNQLSLDTARRELCLRVVEDAWQSESSPFKSIVAAVYGVVLDSLNLDSAIVALPATWIAELHQLLRSIAPTELTSIPNAPSQHKPTLESASSLSLPSSAPSSSEELATREGLQAKWKKQARVKRIKNQLEQERIKRTKFVAMLEDMLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WI43</accession>
    <name>A0A6G0WI43_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Succinate dehydrogenase cytochrome b560 subunit, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_015014</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000205">
        <property type="protein sequence ID" value="KAF0726872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WI43"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008886"/>
    <dbReference type="OrthoDB" id="588261at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03499">
        <property type="entry name" value="SQR_TypeC_SdhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014314">
        <property type="entry name" value="Succ_DH_cytb556"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02970">
        <property type="entry name" value="succ_dehyd_cytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978:SF5">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0726872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="16501" checksum="554510DFB89F25AB" modified="2020-08-12" version="1">MMQRTSQTLAKAIKTQAPAQIRLVSYTERQARLGRPVSPHVEIYAFPVTALASITNRVTGVALSGGFAAAAALAAVGADVPALIHTAQEVIPFFTPVSKIVVAFPITYHFLNGARHAFWEQSPDVLEVSKIAPSSYAVFGGAAALSLGAAAISLKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WI87</accession>
    <name>A0A6G0WI87_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_014911</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000204">
        <property type="protein sequence ID" value="KAF0726919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WI87"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021081"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11709">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="3">
        <location>
            <begin position="91"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0726919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="301" mass="34089" checksum="76CAC6CF81E2C1ED" modified="2020-08-12" version="1">MSMTTSPTAASLESNPVAKELVLKMKETCAASQKQLEKKRQQLLDLQAAQKAVYQSIVQQIATADAQIDEQLRTTREDMIRYDHQAKHFERLLAEQTAAEKNRQHQAKRQKTETPRPPPPHVEIAALGNRPFVASPRWDLERCGQFGCIINLGRTVRTTGEGWNVVIAKEPADHFTVRLTLPPTLRHPFAIGFTREPNFWKIPVINPPRIFAYHKTGWFLNAQKGSLCSRDGHEDEPFVDPLQSDDVLTVAYDYDLQTIGFKLNGKPLGDGPSFQQVKDLQLYPAIVSYDEDVEVEFVVDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJ36</accession>
    <name>A0A6G0WJ36_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_014658</name>
        <name evidence="4" type="ORF">Ae201684_014661</name>
        <name evidence="2" type="ORF">Ae201684_019229</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000525">
        <property type="protein sequence ID" value="KAF0721084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VJMJ01000199">
        <property type="protein sequence ID" value="KAF0727241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VJMJ01000199">
        <property type="protein sequence ID" value="KAF0727244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJ36"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011992"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052649">
        <property type="entry name" value="NCE102-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28165">
        <property type="entry name" value="NON-CLASSICAL EXPORT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28165:SF1">
        <property type="entry name" value="NON-CLASSICAL EXPORT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0721084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0727241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0727244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="366" mass="39078" checksum="0C505298BA9137FA" modified="2020-08-12" version="1">MVAISNAHTAVRALQGVSAIGAMIFISLGYIEYTTGQLSSGAAIFSTVANYTALLSSVYYVGALRMLSWSSSAPRTSYQGLTDGAIAVALTLAGIFHMTSDAKEDCKSQNILFSTYHGRDLFRCGQMTFGIILTFVTAGLFFLTAASSFCVKSSSDASLVSEEAPSAAQEYADVQTPVDAKGLETSTAPVNRPALRALRLGGRAVQFACSAAAFVFTIAGFKHYYTGQYLSPKATYAILATYTCAGYSLWHLVAVEHFKLTRRPALKVERIMDALLAFAMLVAGVVVATSSQITNCDEANAKFEANHKTTLFRCGSMNSGVVFTLISVGMYLVTIVASFMSGAVEENGRLEPTPLNRSRNTISEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJK9</accession>
    <name>A0A6G0WJK9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_014537</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="VJMJ01000197">
        <property type="protein sequence ID" value="KAF0727424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJK9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010497"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05123">
        <property type="entry name" value="STKc_AGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000008">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000048">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053858">
        <property type="entry name" value="Arb2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045270">
        <property type="entry name" value="STKc_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22749">
        <property type="entry name" value="Arb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="381"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="12">
        <location>
            <begin position="638"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0727424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="711" mass="80576" checksum="8D7B15EE0AB016DB" modified="2020-08-12" version="1">MAEPELSQSQFIASHIGFKAKGKGMIACDLDTVAEKFPAKYAMKSLDDFDEEDPEVDFPDPEYVINRVSGFLCDRVTGARIMKTEILNSEVMLSNVISYVHSRMRLELGFLEHSIPYAGAPAMCQFFASKNFNAAKKLLVFVCSSRGATSGIWSRSLLLRSGVNVGSMLPYFQKAIDKGYGVVVLNPNANTVLQPDNTKMPIPGSSTPEEHVHHVWENYIYPSAAHQIHFLAYGYGGVLVTNLLFNPRIMANLQPRLGNLGFLECQASDKCPPELQPFLGPRWVRWEPSDEVGFGKEIPQTTANHLGLIMSAGPKAPTHHSSVTQTVLDSVFRFFEAPNAYEFQRTEARWNRVNVVDKFLNRAAMTQDVPVKKSSMTVDDFDLLKVLGKGAFGKVMLVRRKKSGDIFAMKVLKKEHVVAKAQVEHTRTERKLLQAIDHPFIVRLRYAFQNSGNLYLVMDYYAGGSLFQVLRQQRRFKEHQARLYGAQLVLAFTHLHSCDIVFRDLKLENILMDEDGFIALADFGLSKEHVKMEHDAVTFCGTPEYLAPELLRRKPYGKAVDWWSFGIIMYEMLSGSTPFYNSNRQKNFYNILHEPLDLSSKYFSEDARSLLRGLLTRKPNQRLGFHGGKEVMAHPFFADVPWDKVYKRQIQPSFVPNVPSARPSESSVDMTVSVRGADYVMPEAHADAFNNFTYRCTEQIDNHRPSDIHHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJM1</accession>
    <name>A0A6G0WJM1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Urease accessory protein UreF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_014478</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the UreF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000194">
        <property type="protein sequence ID" value="KAF0727456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJM1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021641"/>
    <dbReference type="OrthoDB" id="2550922at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4190.10">
        <property type="entry name" value="Urease accessory protein UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01385">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002639">
        <property type="entry name" value="UreF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038277">
        <property type="entry name" value="UreF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33620">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33620:SF1">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01730">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009467">
        <property type="entry name" value="Ureas_acces_UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0727456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="23904" checksum="1C063DBAB0962799" modified="2020-08-12" version="1">MDWYTWQLVDSLYPTGGFAHSLGLESAVQEKIVTNSSTLRQFVVASLHQTANLLLPILYEAHANPTAANFLRLDALTHAMLTNHVAARASIAQGTAMLRVASTTAAASSVLQDIKRNKVHGHHVVVFGIMCGSLGIDALATQRLLLFFTLRDTLSAATRLNVIGPLESAKLQTQLAPLAEKILQEKKDRPVEDAYQSAPFLDLVQARHDMLYTRIFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WKJ1</accession>
    <name>A0A6G0WKJ1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_014282</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="VJMJ01000189">
        <property type="protein sequence ID" value="KAF0727768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WKJ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020625"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18037">
        <property type="entry name" value="DEXSc_Pif1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF7">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="163"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="111"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="138"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0727768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="569" mass="62583" checksum="1352DDF960782FA7" modified="2020-08-12" version="1">MTQDVRCDVEIQVALASTGQNISTKRFPNAVLSKRNGGLQVFGERSKTAIRTRGVELYFSQVHRGKLTFIWRDGTKFTQYNCSNGSPTEMQALRDFALRQGAIAKTMQVASTVQATPRPPLRDHTNTVSNLAEDSPPSKKRRLSPPKARQLHQQKPVIEAVQRNENVFFTGRAGTGKSFLLRRLQRLLSPVGLYCTATTGIAAFHIHGITLHHFAGLRPNDNLHSVSSMLTAIRRHKDALFRWQNARTLVVDEISMLGTYGRMFEALEAIARALRQSERFFGGIQLILTGDFYQLPPVAEDRQPSSFCFQVDAWKRYSPLAFGSVANICSGITTSISLDQVFRQRDAEFIAILNSIRIGAYSDAMLAKLNARVAAAPPPDAIHIFTHNDDVIEMNKARLDALQGKAHEYAAIDTGNMELLRGSPVPSLIQLKKGAKVMLTKTLSVAAGLVNGARGVVLGFAPETQLPHVRFDHGHSQVISLEVFAVSANQTVMASRQQLPLTLAYAISIHKSQGLTFSTAAVHLAKVFEYGQAYVALSRLSSLAGLTLTAPLTRQAIRVHPQLSHLSSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WKQ3</accession>
    <name>A0A6G0WKQ3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_014169</name>
        <name evidence="6" type="ORF">Ae201684_014171</name>
        <name evidence="7" type="ORF">Ae201684_014173</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000187">
        <property type="protein sequence ID" value="KAF0727827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VJMJ01000187">
        <property type="protein sequence ID" value="KAF0727829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VJMJ01000187">
        <property type="protein sequence ID" value="KAF0727831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WKQ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007866"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019060"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF37">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="143"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A2" evidence="4">
        <location>
            <begin position="204"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="85"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="316"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="339"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0727827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0727829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0727831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="618" mass="67828" checksum="42628159B61C75BF" modified="2020-08-12" version="1">MLDELMRALEQDHQEWVLTQEGKVVDDVMAKAIKPDALRIVVQKQLQLQKNKALKSDVFCFVNWLRQYAAGFQMYVGLDETPTPAVAPKGEAQRAGRGGGGSRGDGRAKPDASAKGDGKGGAVAKPAAEKSKEDAKPKKKLGCLKCGDASHRVADCPKAAPGEAQKLLDAQLKKWRDAVQVLGDMPERRRTDRGAMVEALVRVDNVLLDTGADVNVVSRGVMDALAAKGASVAVATHDKPRQIYPYGVDAVSLEMRRSVKFTSVTLETACGPLTLRGLQAWVDDTSSLIELIMICSSEHDSRMPSGIIQRLMADGRESDEPRLDESDGMECATPAVERPTGDGRDEERRKKKEEAARGLTAEEAARLESLLSRHVDVFREDLGNDPPVKVEPLKVRVKPDSKPVKCGMRRYPPAHLEYMREHVAALEANGMVYKNNRATWAAAPRIFPKRDAGALRMTIDSRPINACTEPMAWPMPNLDSAMACLVGMKAYFTLHWTKGYWQLPLHADSQEFFSFMTPFGVYTPTRVLMGQTDAVAYCQSVVHQMFGELLFRGLHAWLDDLLGSAKSVASLFDLLDQVLATSAECGLKVSPNKCHFYLAEAEWCGKIISAAGVTHSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WKY1</accession>
    <name>A0A6G0WKY1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_014135</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Folate-biopterin transporter (TC 2.A.71) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000185">
        <property type="protein sequence ID" value="KAF0727907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WKY1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010891"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039309">
        <property type="entry name" value="BT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585">
        <property type="entry name" value="FOLATE-BIOPTERIN TRANSPORTER 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585:SF5">
        <property type="entry name" value="RNA-BINDING S4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03092">
        <property type="entry name" value="BT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="499"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="541"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0727907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="580" mass="64733" checksum="E59A16DD51E29099" modified="2020-08-12" version="1">MASKQPERPKIWLLPEHDADLIEKRILSETTSTTYDYSCFILETDRNFHSPMSKESDECEIEFGALRPGGALDLLSLEAFGLLSQYAAVGILLGVFNALQYPLFQNYLHMEGYQTASYSVLITLGWTSKIFFGILSDCLPIFGYKRRPYMVIGWAICGVCCLVMAISPFPAPYYGKPGLKGLDNLTAEQETFINHKAPTSASFFIVMSMAASLGYVMADVAADAMVVHYAQREPAAIRGRVQTAIYFTRDSFTMIPMLVVGFCMNDYKYGGQFTWSISPTLVYACLTIPCVIAAYGALIHVVEEKADHPGIGQYMQNVRDLLKQRVVWQVCAFMFFNGLFFGYDSTLFDPISSIWVQVMPLVSTSFSIVSQLFRVVAMFVIGKYALNWDWRAGIAVSSVVLVVFDTTIKGMAIWNVYRNQYFQCMLLTLEAIPNAFIFLFSSYLIVEIVQVGNEGLVYALLTTCSNMATPLSIVMAKLVDSFWNATLDDIQIDDTSVRWQVTYSYICAASFKLFSLVFLALMPRQKAYVHVLRRTGSSSTLAGTVVLVIFALGYVYNIVNNILSIFQSTSCLRIAGGKGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WLB4</accession>
    <name>A0A6G0WLB4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_013922</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000181">
        <property type="protein sequence ID" value="KAF0728092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WLB4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016561"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08252">
        <property type="entry name" value="AL_MDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014182">
        <property type="entry name" value="ADH_Zn_typ-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052585">
        <property type="entry name" value="Lipid_raft_assoc_Zn_ADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43482">
        <property type="entry name" value="PROTEIN AST1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43482:SF1">
        <property type="entry name" value="PROTEIN AST1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="3"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0728092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="241" mass="25986" checksum="C324D1691417BAD1" modified="2020-08-12" version="1">MAGQGSNAEYQAVDERIVGRKPTSLSFTDAAALPLTSITAYEAIFDRLGIARKDSSANNPVKKSVLILNGAGGVGSMAIQLLKALTDLTVIASASRPQSTAWVTELGADHVVNHAQDIPTQLKALGIPQVDYILAFTDLPQHFDAIVDRDYSHHGQPPFQKLFAKSVTFVWENMGTRPIFTTDDIAEHHRLLNHVSDLVDAKRIRTTLGENLGTINAANLRKAHAALEAGRVVGKLVLSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WLQ4</accession>
    <name>A0A6G0WLQ4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tyrosine specific protein phosphatases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_014030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000181">
        <property type="protein sequence ID" value="KAF0728205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WLQ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000992"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17663">
        <property type="entry name" value="PFA-DSP_Oca6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000084">
        <property type="entry name" value="Tyrosine phospatase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004861">
        <property type="entry name" value="Siw14-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF14">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE OCA6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03162">
        <property type="entry name" value="Y_phosphatase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0728205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="32228" checksum="42F95BC395E48089" modified="2020-08-12" version="1">MAAIVPPFRFTTVEDRLYRGAYPTLPNFRFLRRLKLKTLISVIPEEPTKDLHDFCVHEGIAHHTFHAEKYSSDSVTVSPTTVVAIIQLMLNKDNLPIYMHCLDGANVIGIVVMVLRKLQNWTKLATLQEFCRFTRDHSVEKDESEYLSSFSAEITLPPNANVPRWLWNGLRIQKHPTMIINTQAGLQLSTQTPHVSTHDNDLGAANATNPAVPVAPGERTNLDTVTTMIGLSMESEKPDLLKRPFDERRDDRGETSLDDDFDSLYYNEDGVAVSIPRSLSALDLAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WM47</accession>
    <name>A0A6G0WM47_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ELMO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_013746</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000178">
        <property type="protein sequence ID" value="KAF0728381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WM47"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008874"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006816">
        <property type="entry name" value="ELMO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050868">
        <property type="entry name" value="ELMO_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025527">
        <property type="entry name" value="HUWE1/Rev1_UBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771:SF56">
        <property type="entry name" value="CED-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771">
        <property type="entry name" value="ENGULFMENT AND CELL MOTILITY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04727">
        <property type="entry name" value="ELMO_CED12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14377">
        <property type="entry name" value="UBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51335">
        <property type="entry name" value="ELMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ELMO" evidence="6">
        <location>
            <begin position="211"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0728381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="434" mass="48563" checksum="3129210BFF13C733" modified="2020-08-12" version="1">MADDAAPPPPPPPIPLRVDLEAENEHHDMPASPASMDDVDPTVLSELPADIRNEIVASLRAESVAPVAPSDPMTWECPMCTFLNHADLATCEMCEFCILDAEAEHDEEGAPVFRIDTAAIRNAAESAKSKLLSAFKASHDKNEEFVQSASAALSKVHNTAAKQLKELSAKLSPRNRVTSKERSSLPSPEVCLELDALRSDLKTACVAGDQVYESLLVHLWTALTDITGPFEREGEGWMNIGFQRKNPDTDFRGGGLLALKCLVYVCNMHPEKMNFLFRDQMPETNKRWYPVCVAGINITCMLAGLLKLGDGSFASSVTPYWPLFSEPDAFFELYYLAMIKMDQIWHRSHATYMQFGEVLHSTKTLIRYVLAQGPKNMDEFVSIADQIHVDDFKLTRRQDYFEDEQDLECPDPHRQLEEDGKAEGITALKYKIHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WMK9</accession>
    <name>A0A6G0WMK9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_013521</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000175">
        <property type="protein sequence ID" value="KAF0728556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WMK9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000442"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF8">
        <property type="entry name" value="BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="57"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="90"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="280"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0728556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="337" mass="35391" checksum="C732B819D48EF88B" modified="2020-08-12" version="1">MFSYLSEKLNVKALGEMIAPTLTPEQQLHQAIEDNLSEKVRHLLDDVKVSPNARTPEGSSPVHTAAYFGRVEIFHMLLERGADISALGPRDNTPLHLACAQGHLEMAKLLVAKGANVAQRNKSNKTSYDVATGDTLRQWLLPLQFQHEDPNDRAAAIQQAQSMGISGFETGYVAPPPPPPPPAGAGNYYGAAPAPAYDPHAALYAPPTHSAIPRHLASQNRRDPSVFRPIQADGFGSTVGNPELSAKYGNHVSVAQTAPPPTLAGPQPTSYAAAAPAPVAPPVAAHQPPPQFKIFNPRAAAASPSTGFGAPPHQAPPSPTGSPADAVDFSATTSALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WNC0</accession>
    <name>A0A6G0WNC0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_013408</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000172">
        <property type="protein sequence ID" value="KAF0728839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WNC0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001235"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="5">
        <location>
            <begin position="268"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0728839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="359" mass="41032" checksum="9392D488ED09E485" modified="2020-08-12" version="1">MTSILSRRLIQVPSAESKSFGIKHTLGASEKRTCYQYIQTRQKAALEFSSPEITRDFIKTKNGVDVYESRLAWHDIRAVTRINGTVKDVMALLSADNTETFAAMQKEIMGDTFVAAKVLDSCLSDSNEDSSHFHCGLKWLALKLDGDVNQPVNFDMVFLDYTDVCKTNDSLWMGYRIVESIRVKGCPAVLGFTRASIRSEVYIVTETTTRGVVEITYAVHMDWKIVGRQRLEGFADAVIQRLCNIRQYCEQERLRKIEIMNPENWVQDAARSKCAVCDLAFQFILRKRHHCRMCGEVICGKCNTKVDVPIGRTKQLRVRVCVHCLVKCRETQTEMLERPSAQPVTRNRHLEQTFLCPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WPY3</accession>
    <name>A0A6G0WPY3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Polynucleotide kinase 3'-phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_012926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000164">
        <property type="protein sequence ID" value="KAF0729425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WPY3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005970"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046404">
        <property type="term" value="F:ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046403">
        <property type="term" value="F:polynucleotide 3'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01625">
        <property type="entry name" value="HAD_PNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000078">
        <property type="entry name" value="Bifunctional polynucleotide phosphatase/kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000737">
        <property type="entry name" value="Bifunctional polynucleotide phosphatase/kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013954">
        <property type="entry name" value="PNK3P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006551">
        <property type="entry name" value="Polynucleotide_phosphatase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01664">
        <property type="entry name" value="DNA-3'-Pase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083:SF9">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13671">
        <property type="entry name" value="AAA_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08645">
        <property type="entry name" value="PNK3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0729425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="443" mass="48926" checksum="545DB16015B5AA4B" modified="2020-08-12" version="1">MDKFVTKATKRTAPDGASSESSAKKAKGTSGAPLPALESCKWETYGSILYMRNFTAVPSTDAVKVASFDLDGTIITTKSGKTFATNANDWKFWHESVPAKLRELAADNYSIVIFSNQSGLSKGKVKETELKTKLNSIVVQLGVPVRVFLLSADDHMRKPRVGAWEFMLSHCQLQVDLAQSFYCGDAAGRPKAAGKPKKDFSCGDYKFAVNIGVPFMTPEKLFLNSTLVEPSPRPSCSPYPRLQTLHTKETSFELDFDPRTLLAETKAILPEWQLAPTSSQEVVLLIGSPGSGKSTLYKSYFSSYGRVNQDALKTPAKCKAAAVEFLKEGKSIVIDNTNRDVKTRSEWIQLAEDHKVPIRAFYLDIPKPLVFHLNEFRKLQKELHPDRSEAKPNVPDMVIHGFYKNMIVPTTEEGFASVVHLPFIPAPGLDAADKKLLASFLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WQ13</accession>
    <name>A0A6G0WQ13_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyltransferase 2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_012955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000164">
        <property type="protein sequence ID" value="KAF0729455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WQ13"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004874"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021067">
        <property type="entry name" value="Glycosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34496">
        <property type="entry name" value="GLCNAC TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34496:SF6">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11397">
        <property type="entry name" value="GlcNAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026218140" description="Glycosyltransferase 2-like domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0729455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="412" mass="47177" checksum="F32303977ED9392B" modified="2020-08-12" version="1">MLLIVCLVVISYEVLSLQGYTSTSPRLHRDNQVLDDADLAPLNLERNAVRRPSIAHSDRSATTLRKRAHTAPPSTTDAVQSRTTMIMIANFRDTARCAETLHSLFTNAVHPEFLRVSIFDQIYLHQGELQCIDAYCRNVGEVDCRRNQVVHSMIHADQATGPTRARYETEKAVADEDFCMTIDSHLVFIQGWDAELHGQWDSIGNANAIITVYPKSTELMHTDNSGLVQLMCHARIETNDPDTMIQYGSPIWIPAPAKPRLMSQFAGGFNFGNCLQAKTIRNDPYTPYLFHGEEYSRAARLWTSGYDFYAPRKDVVYHWYEPRHVMWETDWTARHAMQQASKRRVRATLGLPYVADDFDHTDLDKFQLGTKRTFAQWLAFTGIDPYAPYQGTDVKQFDNCRELELIPYDKME</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WR51</accession>
    <name>A0A6G0WR51_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Heat shock protein 70</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_012522</name>
        <name evidence="8" type="ORF">Ae201684_012523</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000159">
        <property type="protein sequence ID" value="KAF0729881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VJMJ01000159">
        <property type="protein sequence ID" value="KAF0729882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WR51"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005770"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10233">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000016">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="613"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0729881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0729882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="644" mass="70477" checksum="CFF00BADA4D595CF" modified="2020-08-12" version="1">MASVTGQSVGIDLGTTYSCVGVWQNDRVEIIANDQGNRTTPSYVAFTDSERLIGDAAKNQVAMNPANTVFDAKRLIGRKFADPVIQADIKHWPFKVVAGPADKPQIVVEFKGESKTFQPEEISSMVLIKMKEVAEAFIGSDVKNAVITVPAYFNDSQRQATKDAGAIAGLNVLRIINEPTAAAIAYGLDKKGGERNVLIFDLGGGTFDVSLLTIEEGIFEVKATAGDTHLGGEDFDNRLVDHFTAEFKRKHRKDMTQNQRALRRLRTACERAKRTLSSSAQAYIEIDSLFDGIDFNSTITRARFEDLCSDYFRKTMEPVEKVLRDSKLSKSQVHEVVLVGGSTRIPKVQQLLSEFFNGKEPCKSINPDEAVAFGATVQAAILSGNNSSEKLQDLLLLDVTPLSLGLETAGGVMTTLIARNTTVPTKKSQTFSTYADNQPGVLIQVFEGERTMTRDNNLLGKFSLDGIPPMPRGVPQVDVTFDIDANGILNVSAIEKSTGKENKITITNDKGRLSKDDIERMVQEAEKYKAEDETNKQRIEAKNGLENYAYNLRNTLNDEKVKVDESDKKVLDDKISDVISWLDRNQSAEKEEFEAKQKELESVANPIMQKMYAGAGGMPGGMPTDGPAPPSAAGGAGPKIEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WRJ5</accession>
    <name>A0A6G0WRJ5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_012446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000157">
        <property type="protein sequence ID" value="KAF0730048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WRJ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004846"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0730048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="307" mass="33609" checksum="25BD080E4E2E19AD" modified="2020-08-12" version="1">MTFTADDIPDQTGRVAIVTGGTAGLGLHSVIELARKGCHVIFTARSTARGQEALEKIKAALETESLGNVEFAIANQEDLESIAAFADAFLARNLHLHILLLNAGQGAQPYRVVQGVEALLFLNHVAHQLLATRLLPALKRSAPSRVVIVSSMAHSFTKKLDLDLPREDRYDSQGAYSLTKVANIMMGHSLIKDIGHAKVYVNSLHPGVVSTEITRSGNAITTLPWGIRGILESFFTFCMNNFGYKPEVGALTQLYVATSPDIEKNEWQGQYFTPIAQLGEASALSRDPQQIDRLWKWTNDVIARVMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WT27</accession>
    <name>A0A6G0WT27_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_012002</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000153">
        <property type="protein sequence ID" value="KAF0730580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WT27"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002956"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22936">
        <property type="entry name" value="shulin_C20orf194-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057478">
        <property type="entry name" value="DAAF9_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056498">
        <property type="entry name" value="DAAF9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040342">
        <property type="entry name" value="DNAAF9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33664:SF1">
        <property type="entry name" value="DYNEIN AXONEMAL ASSEMBLY FACTOR 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33664">
        <property type="entry name" value="RCG26366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25204">
        <property type="entry name" value="DAAF9_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23281">
        <property type="entry name" value="DAAF9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAAF9 N-terminal" evidence="1">
        <location>
            <begin position="5"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="DAAF9" evidence="2">
        <location>
            <begin position="705"/>
            <end position="905"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0730580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1163" mass="128396" checksum="8EEE94D7356C2BDC" modified="2020-08-12" version="1">MQKCVFTGQDSFHRVKQLQELCKDNECDAILLVGGADGLYSQGSQAALKYLFLGKSGQELLGEQVIPQQFENLEDIVIVLTSRAISIFYILDSDSATFLLPLISSWRNVIEYVATDDMPQDVRELKKIQAFRDMTEPHATIGIPLDTKSDPKMTAEKWPLVQAYGLDEISGRGFFTMHHNVLSCTGSLANRMKILDAYCARRLVNDAAPTLLHHFGGFLDKLENSTPADRAALSEVDAGDDLTSFYEFGTIRDEARGLVKPNHRGARLLFGTRTATPTAAASKAITPAHAGVRGFAASHFTIVAEDPLTGLRAARTYFLGTGKCGVRIVDTEALVHTSLEKLDRYDSIPNNALDTRHLIDLYLAVLEVHTDVLSEFVSMTKTNEPLKKCVENLQALASQLYAKRLDPGLRALATQLTVNAEYIDACGESTALSSAKWAQAYITVTLNSIPSIVVPGEILGSIIVGDTVLFDPNEEKNEEALILTADFARVKAWIQAGQEADFASHVDDVLQSEYMLENVLRVGREIGDSILHASILIHSDQMPSGFVLHSPSCQPLIVSFPTDAKAIRILPTPHEELLLIVIEFRDEPKNSVHKCLPCQVNSTSIALPLLAGSRMQEALLGVLEKWKHSAAALDIPLIKPSDVNDQETKIPVGFQRGCDKLLGHDDQSQVKNRFFPPWFIAKSGLNPVSTWIKPKSHADPINVPVTVFVGVPGSDVQSIACSLIEVSSSTNEWHHVIVEIPHETDSTQLIPCRLASALDGIDTHSSWERRPRILLTVVGYVDTITICAAIKSSPQGHRLKLSAVTAVVSGVALHQPKSFNPVPKLWDQLVAGFVTTIVLTCIQELSKTQLHRLRMRVDAVNPFADVLCLRSASFSDCGDLSPLLALDGFETTDRVNYRDAHFPQWQTSPSTYVVPTTDISAVRFEMQLSVDRYRFLACIQKGLFSHTNLKTTTPVYPLQLPVVELKGLRLAQALAMEKVQQSAVYSTEKEVNLPDNISALASESGCVWTLEASLSFSNDNQHSYAYLNTGSKAFLRPLPPMSAPVCSFVFTGTNLQADKLRQLLLLCCPARHFVVAAVRGPGQITPEEKREIQARHVTDPLPDGYMFDGTSYYDYFGGQYEFHPNIQEFINAYLSKKNDAARLHNIELEQDLLRCEERTKQCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WTF7</accession>
    <name>A0A6G0WTF7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_011868</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat DDB2/WDR76 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000151">
        <property type="protein sequence ID" value="KAF0730759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WTF7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010369"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000001">
        <property type="term" value="P:regulation of DNA damage checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050853">
        <property type="entry name" value="WD_repeat_DNA-damage-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14773">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14773:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="324"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="367"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="89"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="137"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0730759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="503" mass="56390" checksum="EE2BF1986965E985" modified="2020-08-12" version="1">MLRTSARLNAKGNKDDVVKTESKKAKPKKSVAVDIVKIETSESEDDNEVSAYERKRLENIVRNKKLMATIGLTSAASDIKKEEKERIKARNAAKKRRQEELENLPRRQSRRVQGQKAEFEIYHDLNDWIHEKRGTNEQEDDQDDGTDEEAESWANADGAQLLGDFCDGLGKKSQVAAQHSDAPYSLDKRDVQKVIANRVYSMAVHSNCTSSIMTAIADTEGYVALWTTPVDRKKSSNQENGLVPLKPHKQAVSTLLFQDTSLLSSSFDGRLLQYDLTKNTSTEVLNCDVSITNFQIKSQDEMLVSGDDGSLFVVDRRDSKSKKHSLHEKKINTVHIHPNATSAFVTASLDRTVKLWDSRHLKNAVASLPHEKSVNCASFSPDGAHLVTVCQDNFVYLYDINPSSGGLARENPKKIKHDNYSGRWLTKFHAAWDPKKTHDCEFVLGGNKRPRCIEIFGTTSPKPRQALLSDHFNSVHSINIFHPVLNVIVGGNSSGRVALWRQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WU95</accession>
    <name>A0A6G0WU95_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="2">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_011576</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="2"/>
    <dbReference type="EMBL" id="VJMJ01000147">
        <property type="protein sequence ID" value="KAF0731025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WU95"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018966"/>
    <dbReference type="OrthoDB" id="1158011at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23799">
        <property type="entry name" value="UBCc_UBE2J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000023">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 J2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="11">
        <location>
            <begin position="3"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0731025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="185" mass="20955" checksum="CFCA44A198832BE2" modified="2020-08-12" version="1">MDLATKRLRKEYTALKKNPVDNIEAVPLESNILEWHYVIRGVGLYEGGFYHGKLVFPRQYPMKPPSVYMITPSGRFETNVRLCLSMSDFHPETWNPLWSVGSILIGLCSFMNENTPTTGSIETSDQEKQALAKTSLAFNCQPNQIVFRKCFPHLVELHADLLKQAAAIAETSQEAVDDDKLIHNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WUT5</accession>
    <name>A0A6G0WUT5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transmembrane protein 198</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_011486</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM198 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000146">
        <property type="protein sequence ID" value="KAF0731225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WUT5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011611"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025256">
        <property type="entry name" value="TM7S3/TM198-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040236">
        <property type="entry name" value="TMEM198"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31247:SF5">
        <property type="entry name" value="DUF4203 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31247">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 198 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13886">
        <property type="entry name" value="TM7S3_TM198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="TM7S3/TM198-like" evidence="8">
        <location>
            <begin position="77"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0731225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="280" mass="30174" checksum="6ABD01D237A76FBE" modified="2020-08-12" version="1">MLWREKVSRRGILELSLLSIYLMNRTNGTNATAPQDILLAGFSFGTKAILGYLYNDCFDDHGVLLRKSFFFAFVSSLIGIGLVVAFFGYRFIKVIMFLGGIFFGAVIVYDSTIPIRTQIMLSIVTGIFCGVIALLQMKIGVFVKGFVAGFMVGHLVLTTIEPYLPISKWVKLSILGACSLVLAVVALMNERATMITGTAGLGAHLASYGGYFATMPPVHPDGQYWIAAVITGGVTIIAIVFQVTVSAKGLSSDKFSHWFSATQAAGSGGYAAVHDGHWLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WV12</accession>
    <name>A0A6G0WV12_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ryanodine receptor Ryr domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_011405</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polycystin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000144">
        <property type="protein sequence ID" value="KAF0731342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WV12"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013708"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005219">
        <property type="term" value="F:ryanodine-sensitive calcium-release channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000086">
        <property type="entry name" value="Polycystic kidney disease 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013122">
        <property type="entry name" value="PKD1_2_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051223">
        <property type="entry name" value="Polycystin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046791">
        <property type="entry name" value="Polycystin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013333">
        <property type="entry name" value="Ryan_recept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003032">
        <property type="entry name" value="Ryanodine_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877:SF183">
        <property type="entry name" value="AT14535P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877">
        <property type="entry name" value="POLYCYSTIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08016">
        <property type="entry name" value="PKD_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20519">
        <property type="entry name" value="Polycystin_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02026">
        <property type="entry name" value="RyR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00795">
        <property type="entry name" value="RYANODINER"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="470"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="499"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="531"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="Polycystin" evidence="10">
        <location>
            <begin position="131"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Polycystin cation channel PKD1/PKD2" evidence="9">
        <location>
            <begin position="332"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="Ryanodine receptor Ryr" evidence="8">
        <location>
            <begin position="913"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="domain" description="Ryanodine receptor Ryr" evidence="8">
        <location>
            <begin position="1036"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1217"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1217"/>
            <end position="1240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0731342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1251" mass="142858" checksum="F6DEED8D514EF418" modified="2020-08-12" version="1">MSSPVSASTTNSPSTPRRSTLAKQAERLKNMIRGPATPATQTVQTEEMRLAQKMQHYSTMRIHMKRVQYALEEEKRNSFYRELMVYLLFLAIMMMTVCTLPIQIPFEHNDALSDLYLDQEFHNVSFKKNIYEVNSIDEMWQWFDDVLLEVYYDSPQLNSRRISSIQVRTARMKGITCTQIDPTNSLALFPEDVCYKAFEDDDEDTTPYGDTGFGVPFTYENDLSLLVRSLRFTPSIINTRMDYGRGGYTVYLPRDNATAGTALVDVLKDSLVLKSTRYVAATWALYNPSSNVFSHLQIMFELSPTDHIELTQRLMSFRILGYRTFLSFFTTENVLMLFLSVVTLWFTIREVTSALKLGVSKYTQSMWNAFDVLQLACLYLLVFYWYKYLYECHAVIPQLEQVVRHQTCTSPMSGRNCFIDLGYIGNLVQDINNVSACVSLVSVAIVFKYLRLNTRLNMLWTTLRLAAKDLIAFVVIFIFIFFGYAVMGFLLFGNHVREYRSLSGSLASCFQMLLGAFDFDALASANPVMSGMFFFSFMIFVFLIVVNMFIAILSEYYSIAQEAKRKEDETKKHLLDDRIEYDVLNQVTKYVKDLRWRVKLSQKQPLPLQGGACVLLVDYSYLMAERARLRAKFRTTVRVMRICIAFLKPLRKFFSDFDAAHVVTSSLLSRTKLTIRTKSSRHMDYHKFPVTYVPLHSKAAMPLTMIEQLKEGDQIELDDGSLTYDRICLQVMGPQEKYLEGMTPTRPFGLHHVHPDIGSGAHIKCCRVIYQGEIIVAGNETCIVTPWIWFKYFGSSIVKTLARLFTRRFWRSSRDGPKTKNHQISDDDISQLLSAQLVSHGGDSTDTRGQSCRFDELVRQFRLFLAKKMHQGAIRIPNNDLEMCVKHEAIAFVERFSKAVFPLDKRELVGHKYVPAPTDTTHVRLPNAVSRLSEFLAHNAHEVWSQSRINQGWKWGPHRDNELKLHPDLIAYDQLTEEAKQYDRDTSMEALKVIQALGYVMQPKHTSGGAISKSMTSSSMDFDIDFGQAVPEGETYEPKPIVTDDVELAPELNSLVELLAENTHDVWAKKRMEEGWVYGPKRNDAKKEHDGLVPYVYLTPDEKDMDRNTAMQTIKCILRCGFTLKHKESYDASAKPKFKMFGRSEDVNTTRLEDATTVIKNVHKAKAAFLNRRTHKTYGSVAFADATVKTPQPQRSASVDMTQSTFPLTPLAEAVAAPPLSPAATTTTTSTTTTSTTNTTEEPDVKIQIEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WV71</accession>
    <name>A0A6G0WV71_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_011279</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000143">
        <property type="protein sequence ID" value="KAF0731376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WV71"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002932"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0731376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="197" mass="22337" checksum="8B263DE742B8D0F0" modified="2020-08-12" version="1">MADFTWEDFSLRSQVASALLKTTTVDRFMIIGNDAADVYFGAGCGYDNSVLCLEFFKPRRLGLEVSVEELDLDQIAQDLSGLVRPFFESLLAPKVKKLGMRGYGIFANCVIWQMLIPYLPQSHLEELDLDCNYLRDDEVFLLVKGIRHMKSLQKINLNFNDLSYTGLMAIMSAAPATAKHVSICYTIKDLERDFFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WW68</accession>
    <name>A0A6G0WW68_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RWD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_011070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000140">
        <property type="protein sequence ID" value="KAF0731768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WW68"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003073"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051246">
        <property type="term" value="P:regulation of protein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23823">
        <property type="entry name" value="RWD_GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000050">
        <property type="entry name" value="eIF-2-alpha kinase GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040213">
        <property type="entry name" value="GIR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12292">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RWD" evidence="2">
        <location>
            <begin position="10"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0731768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="264" mass="29653" checksum="88E934D6F053B6E4" modified="2020-08-12" version="1">MTDYAEEQMMEVEALESIYMDDFTKVQDAPLVVKVHIVPNQDGGKNHGKWIYRWTQCSQIVVALSLVFKMPETYPDTAPNVDVVLEKGLSDRQEKEIRALLDQQIEENLTMVMVYTICEAVREYLLENNREGNDGSEYQEMLRRQEQRQKKDTLAAEAEQAKIDASEAGSASKSNVGTPVTVETFAAWKKAFDAEMATKEGTKGAANGEKRLTGRQLWTSGAAKEDTSTDADEIGSQRLDGDDDDEDDEDYVDGQDEDDEVDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WWS8</accession>
    <name>A0A6G0WWS8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Transcription elongation factor SPT5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ae201684_010892</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Plastid</location>
            <location evidence="2">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the SPT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000138">
        <property type="protein sequence ID" value="KAF0731940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WWS8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002458"/>
    <dbReference type="OrthoDB" id="28901at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06081">
        <property type="entry name" value="KOW_Spt5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06082">
        <property type="entry name" value="KOW_Spt5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06083">
        <property type="entry name" value="KOW_Spt5_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06084">
        <property type="entry name" value="KOW_Spt5_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06085">
        <property type="entry name" value="KOW_Spt5_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06086">
        <property type="entry name" value="KOW_Spt5_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09888">
        <property type="entry name" value="NGN_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.940:FF:000005">
        <property type="entry name" value="Transcription elongation factor SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="entry name" value="NusG, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041973">
        <property type="entry name" value="KOW_Spt5_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041975">
        <property type="entry name" value="KOW_Spt5_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041976">
        <property type="entry name" value="KOW_Spt5_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041977">
        <property type="entry name" value="KOW_Spt5_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041978">
        <property type="entry name" value="KOW_Spt5_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057934">
        <property type="entry name" value="KOW_Spt5_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057936">
        <property type="entry name" value="KOWx_Spt5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005100">
        <property type="entry name" value="NGN-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039385">
        <property type="entry name" value="NGN_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039659">
        <property type="entry name" value="SPT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022581">
        <property type="entry name" value="Spt5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017071">
        <property type="entry name" value="TF_Spt5_eukaryote"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125">
        <property type="entry name" value="SUPPRESSOR OF TY 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125:SF7">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23042">
        <property type="entry name" value="KOW1_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23284">
        <property type="entry name" value="KOW2_Spt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23291">
        <property type="entry name" value="KOW4_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23290">
        <property type="entry name" value="KOW5_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23287">
        <property type="entry name" value="KOW7_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23037">
        <property type="entry name" value="KOWx_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03439">
        <property type="entry name" value="Spt5-NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11942">
        <property type="entry name" value="Spt5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036945">
        <property type="entry name" value="Spt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="13 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0934">Plastid</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="12 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="KOW" evidence="16">
        <location>
            <begin position="262"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="16">
        <location>
            <begin position="406"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="16">
        <location>
            <begin position="461"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="16">
        <location>
            <begin position="587"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="16">
        <location>
            <begin position="673"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="16">
        <location>
            <begin position="1038"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="646"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="730"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="766"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="56"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="736"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR036945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF0731940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1089" mass="119497" checksum="6719394D0DD7A922" modified="2020-08-12" version="1">MSSEDEDMRSDDDEQENIDDYSDEDEEEEVSSKKRKGTAGKKKKPKKPKVMSFIDDMADEASEDESDEDDYPGGGFLDDEGDEAEREKEGLDQRPPRYDRPNRPAYDDDDTEEYIRRLQERAKKQTHRGNDDEDEDNLESVQSAVAQQSLLPSIQDPRLWVFKCKPGREQHLVLALMNKFLEMSKRGQPLHIKSVVASSSKGFIYVESEREPYAKDAINGIRDIFQWSMKLVPIHEMTSVLTIQSKKTPVTAGCWARFKRAGVYKGDLCKVIEVVDNGLRAVVKHIPRLDQAVLNGGEQPKYKKGQRPPLKLFIPNPAHGSAEVTRKRHPLTNEMMDFFDNEWFKDGFLYKELNIATMLQLDEVNPTLDEINKFSHTATEVDSDNEPTSITKLDLGDADAWKNKVDLTKGDTVKVIEGDLINLLGVVVGTNSNNDTVRVMPLHEEIKDTILDFQLKQLIKIVKVGAHIKVVSGRYSGETGTVVSIDESLGAPVAIVLVDTQAKEIQVRVRDIQESAEVSQGLDSLKGKELYDLVALPHGEVGVITRVGRDGFTVLVQSGQTKTIADQEIQRKMFSTRASALDKKGNPITVGEMVQVVDGPYSGESGTIKHIYRSFIFLHNNRVSMNAGIFMVRNRQLVLAGDKMKSKAPAAMGGGPNDRMDRQQRGGPRGFQSDLVGKTVKIKRGQWKGYIGMVVDESDNTVKVEIHCKSKCVEIEKKYVTVAGDRQGVHVDRTHGSSTMNSSTSQTPMVSQTPLHHGMTPMATPLHVPRTPSRSGNYPSGGRTPRDAWSAQNDDMLLEANLPHEKEISHAQSFGTPLEPVVPSEFGVASTYKTSSSSSYSDMNSVLNHPTTPGLLNPTTPGFQGSYSTPGLQPTTPFVSTPGMPRNSVQTPLQTPFQSHSSFGPTTPGINMMHHPTTPGISMNPTTPGFAAYTPMNPTTPGLFAKGTPAATTPHMGVGATPAPMTPAGGQFYESGFGSSSGNNESSWMSKGVVVEVTQSGEYYQAEGVIVTVGQDTCLLDIRGQMVNIHVDGLKHVIPEKNNNVKILVGEEAGKTGSLIGTDPPDGIVKMDSTAEIKIYPLSHLAKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WX33</accession>
    <name>A0A6G0WX33_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kazal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_010787</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000137">
        <property type="protein sequence ID" value="KAF0732136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WX33"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001078"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050653">
        <property type="entry name" value="Prot_Inhib_GrowthFact_Antg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10913:SF45">
        <property type="entry name" value="FOLLISTATIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10913">
        <property type="entry name" value="FOLLISTATIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00050">
        <property type="entry name" value="Kazal_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0722">Serine protease inhibitor</keyword>
    <feature type="domain" description="Kazal-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="4">
        <location>
            <begin position="37"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="4">
        <location>
            <begin position="91"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0732136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="155" mass="16586" checksum="5E4E50B7B7BE7169" modified="2020-08-12" version="1">MNPVCGSNNVTYNNLCLFGFAQCDNATLTMTAVGSCDAPRLECPSVCEEIFSPVCGSDGITYANKFEYRRGKCANLALEMVNPLGPCDESQPVESDCSVVACISVWDPVCGSDGKTYSNACELDIAKCKQGSTTLQIAHKGDCAVHRRRPSQEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WX56</accession>
    <name>A0A6G0WX56_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_010718</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000137">
        <property type="protein sequence ID" value="KAF0732065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WX56"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005721"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43102:SF2">
        <property type="entry name" value="GAF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43102">
        <property type="entry name" value="SLR1143 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="5">
        <location>
            <begin position="258"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0732065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="700" mass="77446" checksum="857076790171C7BE" modified="2020-08-12" version="1">MDLVDTASTYRTKKTVAFAHECAISFAKDCLQWNQRVRTMAQRESSIYCELNRETKQYFVHSTIELYAQMDDVLGVFTPTKNTKTDPFFSRVFDAPVAVSVVVEDLANERESMTSNQQLSTRTSRSLQFTSVKRLSFSEKPWKKELLCLEHIEYLSPTAVVRFYESVAGWAAIENAARHSTVNAERHENLTFGFLFESKPPNRLRLTFLGYHSTEGNTNTETCKWLEKVCGSVELIKKIIQRRRLAQETSPPQHSLMHTAARCCRICTKSFHLFRRAHACQICHATVCSKCMRAEDVETGNGLVAPAQVCYLCHHRLKDEKTHAVPRRRRHSSRLSKTIRIPARSSHSPAAANNAPLTDPEVIEFETRRQLLGAAMIPAYRPSHTPPPRPPAPKAPVLCSRCRSAPSIGQCGACSKAFCASCSVVHKVQVGDANVFDLQLCHTCLTKSMEQQPSRATTVEPILLRESYLPEAGLMHTIPLHPQPASNEPQAVPLLELEAPDSQDSLESIDAMVIDDGDNQLEEEQVAGNDEIMAEEQLQMFACLDVGATELHDALCVDAAAALEVANAYVTLIYQGTQVLKGAHGPTIPSQIPSSCALVQAILDAPTSTLLIVPDASADDRFASSLRVTGSEGIRFFCGLALTTSDGHCLGTVSVADTAPRLRMAAVHRNALKDFHDRVVALIEDRLTLALENEQDNKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WX84</accession>
    <name>A0A6G0WX84_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_010835</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCR4/nocturin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000137">
        <property type="protein sequence ID" value="KAF0732186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WX84"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002030"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF45">
        <property type="entry name" value="NOCTURNIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="3">
        <location>
            <begin position="27"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0732186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="302" mass="33962" checksum="BBCBB8F2EA17BE6D" modified="2020-08-12" version="1">MSTELLYDRKVRVVQNTEDDSEGVVFMQFNVLADGLCDLRKDKGGFILSPPESLPWTYRRSLIVAEIERFAPDVICLQELDHMDWMQTHLSDLGYAGHFVSKPHSPCLEYSNNADGCAIFLNRAKGLHMKHMCSPRYDLEDGSPSSQIALIGKIYQYDSPLFVVACTHLKATKTAEGEALRLSQVKQLHTHMLEHGDIPMIICGDFNAEPQDVDEVPALAIPEMLQCGWKSAYAVAGSEPAYTTWKIRPGVESRHVIDYIFYNDKLTLLSVVDAPTEIDDCRLPSLKYPSDHIALIAKFEIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WXA4</accession>
    <name>A0A6G0WXA4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleotide-diphospho-sugar transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_010784</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000137">
        <property type="protein sequence ID" value="KAF0732133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WXA4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021221"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02537">
        <property type="entry name" value="GT8_Glycogenin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0732133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="32764" checksum="829100FE8FD89430" modified="2020-08-12" version="1">MPACAYATLVTTDSYLRGVKVLRASLTAQRSTYPLVVMYTDKVSPEVVQEIIHLHNVILVLVENLKPRRDQTTKYAFERFEDTWTKLRVFELTQFETVVFLDADMLCTQNMDELFTKIDPSSDSLVASLACICNPMKLAHYPKWWTPDNCAYTKLENGIPVDPAAPKYFNSGMFVLHPNAATFERLTSRLYKEADLSRFFFSDQCFLNEMFPDFRVVSYGYNALKTLRSAHPRQWKDDDVKNIHYILTKPWNVDPGDPKQRDEFYDLNQLWWNAEAAAEVPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WXP4</accession>
    <name>A0A6G0WXP4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_010559</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000135">
        <property type="protein sequence ID" value="KAF0732267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000333"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005221">
        <property type="term" value="F:intracellularly cyclic nucleotide-activated monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.630">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050866">
        <property type="entry name" value="CNG_cation_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003938">
        <property type="entry name" value="K_chnl_volt-dep_EAG/ELK/ERG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638:SF11">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01463">
        <property type="entry name" value="EAGCHANLFMLY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="539"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="564"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="673"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="773"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1045"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1075"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1185"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1272"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1594"/>
            <end position="1616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1622"/>
            <end position="1653"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1737"/>
            <end position="1762"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1835"/>
            <end position="1856"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="381"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="875"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="1376"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="1938"/>
            <end position="2036"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0732267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="2069" mass="238600" checksum="66A6719C8B4FE17B" modified="2020-08-12" version="1">MLILEALQLLYVGFSIPFRLGLLYNPYRDNSMPTVVMYLIWAFDVLSDLIALLAAFETLKEMMISAPVASLGPMDLNFSSDTNDRRNSGYMSKLVKMSTTRQETMRRNSVFLAKETAMKPQFLLSSSWDKKRQIGSIHIFLDWFAMIPFDLFWFGNSNAMILGRLSKMLRMRKIGEVARLTKHALADHQLLAGFHNIGMSLLVGVILLSLVLIHWAACLFLLLAHLECGYNLNEPVDGKQCWGQEVELEGASIFRTYVYTMVVVGYGFPVPRTNAERIAVIGIQFMRFCIAGGIIGAYFFLFECQNRQANEFHDQVDGVKEYLTARRLSKDLQTKVLDFYEHFWSAQRGIDEVAIIATLPSHIRTQCYHYLRVKLLKNVPIFRNQPAHVLKRLMERMKRQCYGRLDSVVENGACKALYTVSRGRIALLNAKNSVLTHVTEGQCFGLSCIVSNSNECHAARAETFCDVYTLDRASIEEVVLLYAQLGEITWHAMIAEAQLILQKNMTNAMLVKGSTFVVKPHDNDKWTVVNSKFRKRWEICVVCVLVLFLIDVPLHIAFNSPKGWFVYSVRLVLDIFLVIDFLFRARYFAYVEMDTVITNSWFIWREYLRHGLVLDAISNIPFAMAADLLPSSTPQWLFLTLQACEWLRFLRMRSLFSTLSNVLKQYHVNNTTYIIVCIVLCVPFTCHIGGCVWYWISKITSSPSHNGHEGNHMTLKECLSWARDFDNCTWLDFDHAHFGHSSDYVRAFYWSVVSLVTVQFGSILPFTDAECVYMFLWLFLSSIANYGALGALANAVTRINWAISAKQLQVAVAHRFMLSERVSRTVRRDVNDYYKHHWTQSTEHQVMSVLKPLPDNLRQEIQTFLHEKSVKHVKIFMHVNADGLRFIYSVMKHQSYKRHEFLVRAGDACDTIYIITRGVVEALLSLDDFQVPVQLHYPGDCIGEAAFIQKRPHDLSFRVVGGSLDVSVLDRHEFMTGAMHFTHLGPEIDAIAAELFQSETKFVEQIERNLRRAHIYRTLNQSPTLYIEPKLDDYLIRPGSMYYRLWELLISAVVTYNLIQISFRIAMLLTPSHDLLLSIWIIDIICDIIFLVDMYIKYNHLIHMDKNGDEVVSVSLIRANYLQGAFKLEALSSLPLYYFGDFRIMTACRLPRLLRCYQLPSLLHTFHMFVQEQTSSAIISEGLEFLKLFIGLVLASHLAATGLYFISYQQYTSMHTSSSNDHGVGVWYEHDFVIEEDPHSLSMVYLRAFYWGLGVLSSFDYMDMEVAMVGETLWFCAVALSGVLFIGVVIGQVTTAIFNANKEIREVEMQVDNFAFYAKMKNLPPYLIRRATLFFQFQLDCNRGMDAHVIFEDLPQSLCLELFHDLYSSMLAKIPIFSSFTKGQLNTIAEKLHTRLYLPGDNIVVEGDMGSSLYFLKQGLGEKYLRSCHLIIAPCYKGAVFGEAGFFLSMRYVYCVRAVKCCEILCLSKADWSEAWSADVRAKLEAKVMRDIQHELSILRRNIHAIKQNFGITRPIPLKLTMMLESSSSAGIPQTTADVSGRNFFEYLKHTAPSKAKVNPLATAPLREFTIWSLGPPPAAVWKPDSLFRQTWDIMMLGVVIYYAFLIPFRASFIFVPTMPPLWLIIWLIWDYFLDILCIVDTILRWQVFYVFVEGEVQTNRAILRRHYQAHGHFYADLLSLLPIEVFVLAFPHRNGWEMISLWRLNRMIRLSHFSHLLSTFQHILNRHHWFHDYKMIFQYIVAYVGPFFLVCHWVGCMWFHVSYTYRHMDSPSWLVTAGYINANETISDGIPIEFSETTQLTSLNLYLASLYYAVSSLTSQSLGDVFSRNPLETWLTIGIMIFSIAFYGLLVGILSEMVEDRLNPRATFEQRMVDISTFFNYRMLPFQFFIQTSRFFRTQWQEQLARTEDEFLGILSTTIREDIAMFVKQNFVKNLSFINHVEEVFVRALVTKLHTEDYIMSDVIFQLGDVGRVLYFINVGHITLVTSKNASKTCNVWDFFGGTSLFTDTGRQATAIANVNCTMFLLYFEDFDRVIQRFPEYYEPCRNEWNVSDAVELDNANRITQVPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WY59</accession>
    <name>A0A6G0WY59_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_010531</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000134">
        <property type="protein sequence ID" value="KAF0732422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WY59"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005506"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0732422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="210" mass="24285" checksum="1EDFD6BDA11EF373" modified="2020-08-12" version="1">MTHATLRVLTSPELNNVISSYQHGAYEDMRGLRWKLCPLYDGFYDPSYIRPHMQRVDDFLRPWLAKHGMKRLPKLLEYCSMMRLILVQYAVHFGNMDLATHLHKTVNLLLFPRWLHDLAALNNQVDMLRFLQQIGHCGTSTRGLVWAAEFGHLPTVKYLIDMHKALHNDNVSRSTAARVAAKAGHLSIVRVLLNPKQQRFPQFVLTTTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WYL4</accession>
    <name>A0A6G0WYL4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aquaporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_010294</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000130">
        <property type="protein sequence ID" value="KAF0732586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WYL4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013253"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015254">
        <property type="term" value="F:glycerol channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050363">
        <property type="entry name" value="MIP/Aquaporin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829:SF9">
        <property type="entry name" value="AQUAPORIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02019">
        <property type="entry name" value="AQUAPORIN7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0732586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="302" mass="33113" checksum="DC1EF13FCFD3855F" modified="2020-08-12" version="1">MINDYKPMDNVRENGKGEKVYPWWRIRSHFARECLAEVAGTFIMLLFIDGVVAQVVLGENKKGDYTHISIGCGLAVMLGIHASGGVSGAHLNPAISIALAVYGRFPWKKVPFYILSQMVGAFLGALFVFIVYYPAFNTFDPERTVAKSAGIFATYPMSWEYQGSAFVCEMLGTALLMFTIFSVDDPTNMPTNPIMKPITVGLIVVMIGMSFGMPTGYALNPARDLGPRIFTAIAGWGSAVFTADNHYFWIPICAPIVGAILGGGAYIAIISNHHDEEDDFRASFVPEMRVSQVPDFRSPLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WZ74</accession>
    <name>A0A6G0WZ74_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_010027</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000127">
        <property type="protein sequence ID" value="KAF0732917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WZ74"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006102"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024119">
        <property type="entry name" value="TF_DEAF-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10237">
        <property type="entry name" value="DEFORMED EPIDERMAL AUTOREGULATORY FACTOR 1 HOMOLOG SUPPRESSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10237:SF14">
        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="229"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0732917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="295" mass="33668" checksum="1E6797D20E010FDA" modified="2020-08-12" version="1">MNEEQCNHVERPAHALKMNIAQKAQYASSMVFYVHELNEETECSIIKSASLIISQQRERAIFTLACGFSDRPDLASVDALIFFLELSVDAFLNHDFPSAHSFYALHLIIDGCMKAGGHEEFFQATLTPLYENQNISPKMCTPWGTPVILHPVDRTEDMITEPIKVLFKRMIALSDEGLLLASMLFNPGIKCNCLQVEDPHHERFGQRLPSDNLFHTPKASKSRAYRMKCQGCGKTPSNQKSFKSCSRCKRARYCSQECQRAHWPEHKKLCSEKRAGWWGKAPQMSQEERRKQGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WZQ7</accession>
    <name>A0A6G0WZQ7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_009907</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Host cell</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000126">
        <property type="protein sequence ID" value="KAF0733085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WZQ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019109"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043657">
        <property type="term" value="C:host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045379">
        <property type="entry name" value="Crinkler_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20147">
        <property type="entry name" value="Crinkler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="244"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0733085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="556" mass="63193" checksum="C627E521A743D24F" modified="2020-08-12" version="1">MPKLFCLVVGHEESPFSVNIAADETVDDLKKLIKEVNMYQFPANKLQLYRAVKGLSRDEAKAVRLDADGNIPGCIKMDELLIIQNKGHFGMNFQPEEGKIYVLVVVPVGPASTLSSALVENFDKQWLRGIVQFSDDLPNVSELEKIASGSLRIRIPVGDPSGLFADIADLAIPPDELIAQVFEESTVRHCPLVMQRLKEVLFHESPVGDTESIGAKINQYSKNSTATSTYRPDYVFLLFNVCVFRGEEKTDGWTYDPAPYIFGYAVSGFYLCLYAIEPIRVKSEQKRSDKKPRVPSCQTHLLGRFMLNTYRGRLELFRSLVNISQFFKKIADLCPRPADNISWGKKRITFKQRNGVSIVKKTFPSSEASWRIEHLKLIYNEMKQHQVPNVDSLIGTGRNYVLLSPVGECISKDKKRNPKNVTELLQALVSVLEALVVLHSMGWMHRDIRWANVVKKKESSEWFLIDFDDAAKSPKQNNPSEHLTRQEHAPEIYEDGSHTTSVDIWAVGNLIFRWNHSRPEVLDNFGLRLVDENPEKRPKAGEVLKKIKAMLDKKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WZT1</accession>
    <name>A0A6G0WZT1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_009953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000126">
        <property type="protein sequence ID" value="KAF0733132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WZT1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021306"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0733132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="417" mass="47705" checksum="0C143D63D705DE34" modified="2020-08-12" version="1">MEQDRITLGQIVGLLGSISRRLDVLEKQVQCMPGRIWTDLGERVPLPVGGVDVSHSLRLAFQAFTNSILESTKQTVERTTMPPPPQNFSRRTTKPVAEQAPPVERSTPNTLEAPRQLPTEYAEFKWSDGTIHPMPEDFEMPKKVNTRIMWGLWFHGDQDRNICPFRNFQRKDFTSNISRNCLWTARRVMNALVHIALANRWVPDEEAISLLGPNAFEILFEKTFNELIKPPSDNYDIGEKPAVIPKRLAKFSYTNVYKSCLATRKPRIERDPINLPPDWEFPQTTCRAMWRLWFHGDRPRGVGPLRHLRSIDFRQSGGKVAESASRIPAARGLMEKLVEIAEEHGFIKSADELNAATDATTLDSIFEDAFDILLNYNPEGNLAGDEQGLLRSYKAGEYSYLTVINVMREQQRKRKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X134</accession>
    <name>A0A6G0X134_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="18">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">Ae201684_009534</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="18"/>
    <dbReference type="EMBL" id="VJMJ01000121">
        <property type="protein sequence ID" value="KAF0733600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X134"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003107"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02081">
        <property type="entry name" value="P-type_ATPase_Ca_PMCA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000014">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000029">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000045">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022141">
        <property type="entry name" value="ATP_Ca_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF369">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12424">
        <property type="entry name" value="ATP_Ca_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 18" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 18" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-1278">Translocase</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 18" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="361"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="797"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="830"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="874"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="916"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="955"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="988"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="19">
        <location>
            <begin position="24"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF0733600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1080" mass="118233" checksum="68BCB0FF8FB0D192" modified="2020-08-12" version="1">MHMKLSVEDLVRLIESHNDDAPGALAALGGVEGVANALCVSLDHGLDERNPDDIHERERLYGKNFIEPEPPKTIFQLMWHAFKDVTLMILTGAGVLSIILGFLPLPTSSSSTTTRKLASSLRHTWIEGVSILFAVAVVTLVSAVNEYQKEKQFRALNAVKEDEKIKVIRNGVPAEVSKFDLVVGDIVRVDLGDIIPADGLVFDETDLKLDESAMTGETILIHKDSKAAPFLLSGTKVMEGVGKMLVICVGENAQAGIISKLILSNSVKKKLWEKGSKQDTIGTEYSLMSTPREEYTDEKPIMTEPEPSSPLQGKLNRLAIFLSKLGLSVAIFVFVALVVRFSIVKFWINHESWDRQYVEDFVSHFILGVTILVLSLPEGLPLAVTIALAFSVREMLKDNNLVRHLDACETMGSATTICSDKTGTLTTNRMTVVECYLDTEEFTSASSLQLRACPTTQRLLCDSICINSTAEILPPKQVGAQPEHTGNKTECALLQFAADMGVQYAEVRKSASICHMITFSSAKKRMSVVIPLSATRCRIFTKGASEIVLGLCTSKLNLDGSVSEFGPADYALVNSSIIDKYANQAYRTLCLAYRDVDGSPEEVKSWSDDDIEKDLTCICIVGIEDPVREEVPESIRQCNQAGIVVRMVTGDNIATAKSIALKCGIISPNDGSLVMEGSAFRARVLDSNGNIKQDEFDKIWPMLRVLARSSPKDKHTLVSGLISSNVVPHGPQVVAVTGDGTNDAPALKKADVGFAMGICGTAVAKDASDIILMDDNFKSIVNAVKWGRNVYDSIAKFLQFQLTVNFVAITVAVVGAIVMEESALTAIQLLWVNLIMDTFASLALATEPPTDMLLKRKPYPRTKALLSKKMVKHIVGQGVFQLVIVLVLVFAGDWLFDIPSGRRNNQILVPGERNPPSQHFTIVFNTFVFLQLFNELNARKIHDEMNVFQGLWGNHMFLGISIFQVGAQAIICQLGGRAFGCKMLTTAQFFICVGLGALSLPVGFVLRSITSASLPGVYTASRDNEAEIRRLAASARSQELWMRGLRRVRAQVRVVNAFKSGLDPLRRRQLQSIATTTDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X2K6</accession>
    <name>A0A6G0X2K6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Polynucleotide 5'-hydroxyl-kinase NOL9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_009001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Clp1 family. NOL9/GRC3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000117">
        <property type="protein sequence ID" value="KAF0734133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X2K6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018883"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000448">
        <property type="term" value="P:cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057570">
        <property type="entry name" value="NOL9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057573">
        <property type="entry name" value="NOL9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF3">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-HYDROXYL-KINASE NOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24419">
        <property type="entry name" value="Cupin_NOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25467">
        <property type="entry name" value="NOL9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NOL9 N-terminal" evidence="11">
        <location>
            <begin position="26"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 P-loop" evidence="10">
        <location>
            <begin position="239"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="NOL9 C-terminal" evidence="12">
        <location>
            <begin position="454"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF25467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0734133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="598" mass="65724" checksum="029B2E329737AB93" modified="2020-08-12" version="1">MTDKTDQGAMQQLMAAYCATDDKIACLPSKRHFVIGMELNEKLVGAGMVHLRVFQGEVSILGYNVPRGIYFDLFSPRWSNLMAIQASDTSTAPFQAPCSNLTVKRWKLTHNDPIDPTDEAAADTLAQEIAMRFPIVLVLRAMHLTYGNLSSYFDATALSDALPGFRIIRHKEVNVEKLKSKKLKTASDAHTDALTVFSSITTIEPHPVKEILVPPSWTSSVASILESFGESNRKVLVCGAKGVGKSTFSRYLVNRLLNVHRVVAYLDTDVGQPELAAPGVLSLHFITTPLLGPGYTHLQPAFRSYFFGFSSPKADPTLYMNGVEALVAAYASHDTSIPLVINTDGWIKSMGYDLLNATLTATSPAHVVQVVALSKAKSFDVPISSEWTLHPIEMWDADPPQPTRSSKELRQFRLHAYFLGDVPVPDNVSLVNVHCTSEQTRYGRLLSTIYPQQVPYRVPFANVALRFSGASVPPSQVLHVLNGSVVGLCIHPHDVKPANDGPLVILDNPMVPCVGHGIVRSIDVERREYHIVTPVPPKILQHVNLLVRGHISLAFQLLDQSAVYGHTPYVVIDVLPAEGTGASLMESRNNLKRKKEMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X317</accession>
    <name>A0A6G0X317_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Origin recognition complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_008977</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">ORC is composed of six subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ORC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000116">
        <property type="protein sequence ID" value="KAF0734294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X317"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001548"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041083">
        <property type="entry name" value="AAA_lid_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF23">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17872">
        <property type="entry name" value="AAA_lid_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="236"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0734294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="552" mass="62676" checksum="2CB8366FCD3C0147" modified="2020-08-12" version="1">MVKRGKGRQSARAQSHKWLGGSIGSLNGDEYYGGVAMKLANSTVQVQQYSVVRLRQSKDLAMIHVFWEEQDRTMKMEVRYLKHWTSLPSVLQKKIKRSIQAGDELDEMVETTEIDELPVDRVESLVDPASEYICTKLYAHLTRTVTSISPKDDLKRRCFVHSRRLKAVLSKKRTSDIYDSEDNGDSRLNPVERFKQRLEAACDQLQLSSIPDELLGREEERHQIFQTLRSAIVDGDSSPVYISGLPGMGKTATVKEILRSLEYERDMLTIPAFTWIESTSFNPKRARDSLHALFSSQDDDRPVLVLVLDEMDFMLSGKNTVLYNFLEWQSLASSKLVIVGIANIMDLPERLAPKLRSRFGLHRIAFRSYTHEQIQAIIHHRLIRLQVFEPGAIEIYAKALAHQSGDIRKALMVCKAATERALRRLTDTNQTTQVLSSDIEAVQNSMSQSPLLLRLRQCSTFECIFLVALGREIKLNGGSGGTLEGVAHRMSNLCKTAGLTRVPSFAEVQALYYELERSDVLREKKGRLVLTFSHDEIHEAFVSHPVGRLLWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X334</accession>
    <name>A0A6G0X334_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Enoyl-CoA hydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_008926</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000115">
        <property type="protein sequence ID" value="KAF0734321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X334"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017575"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051750">
        <property type="term" value="F:delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000004">
        <property type="entry name" value="Delta3,5-delta2,4-dienoyl-CoA isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045002">
        <property type="entry name" value="Ech1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149:SF1">
        <property type="entry name" value="DELTA(3,5)-DELTA(2,4)-DIENOYL-COA ISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149">
        <property type="entry name" value="ENOYL-COA HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0734321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="319" mass="35735" checksum="92F79BC5C576DCD2" modified="2020-08-12" version="1">MLTRTLAKVSRREAPFKRQFSDKILQHWIRPEVATPLHETRFETLSITPSLADGLANSDPSVLNVRLNCPKKINAFNMQMWEDLETLFERIQETPSIRAVVVRGEGRGFSSGMELQVFAEIQEVLGKVPCESKKREGLMKVIRRFQHIISAPERCRVPVIAAIHGICWGGAVDFITACDLRVCDNAADFSVKEVDLAIVADIGTLQRLPVLIGEQRAKELSYTGRSFHGAEAEHIGLVLKHHVDAAATFEHAAQLAQTIASKSPVTVRGVKKAINYRRDHSTEDSLHQVEQWNASMLLSEDLIEAYMSMTAKKPPQFKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X3K9</accession>
    <name>A0A6G0X3K9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_008886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000114">
        <property type="protein sequence ID" value="KAF0734426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X3K9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020570"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0734426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="467" mass="53051" checksum="33F79BDB6ED63EC7" modified="2020-08-12" version="1">MQDRMQPPHMHGLPRPTHEMERFQQHQFQNQWQSQLAWIQGQLDAMPNDIVGKIDAKVENIRGDTNMNLDRIARRLEAIELQLASLSQQRQQCMTCGNALLHAQGQMAAAAAAAAAAAGPQIKMQNMNGARLGGARRATKREPKQPRQAPATRVVARPARPRTQPTSIDADSTIFMWSDGTQHYVPENWKFPQTTCLDMWDLWFHGDEAEDGSRVGPYRKIRGVDILEPYSKRGLYVARRVMKFLVDTAISKGFAASEEAIAELQEADLRNVYRQTFEHMASNAELYLSKRVDSEKWATASYMVVYDALEKGRRAEKHEFTFTWSDGSLRLTPENWRLPTANCSAMWQLWFRGDPVAGIGPFRHLKEGDVENRQDLYRARTAMNKLVELAVEQGIVTSPDDLTALTDAELETAFELAFDDFALHDLDNPKGGAVPQDMSVRQFYECLRKRKRSNEADMKVDIKTVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X4U5</accession>
    <name>A0A6G0X4U5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Receptor expression-enhancing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_008464</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000102">
        <property type="protein sequence ID" value="KAF0734991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X4U5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000083"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF161">
        <property type="entry name" value="RECEPTOR EXPRESSION-ENHANCING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0734991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="254" mass="28096" checksum="33BA31BF75059581" modified="2020-08-12" version="1">MKQAFTIENKSQIIKLYREIKKEGLTFSPFVFSRLSLSLELAAPSSTTRMEHVQAQLDKIKAELSKVQLLVEAEKQTGVDKLYLAAGGAVVLLLVVLLGFGAGLLCNLVGFVYPAYESFKAIESENSNDDTQWLTYWVVYSCFQIVEVFVDFLLYFIPFYYAFKLGFLVWLFLPSTQGATFVFNHFLKPFLKSHESTIDSAISGIKNSSGKVVGDVTGLMADVTKDVTSAVAQKLVDNQVKSQNGAPSSPKKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X4Y4</accession>
    <name>A0A6G0X4Y4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_008522</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000103">
        <property type="protein sequence ID" value="KAF0734859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X4Y4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010403"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019149">
        <property type="entry name" value="ABHD18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13617">
        <property type="entry name" value="PROTEIN ABHD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13617:SF14">
        <property type="entry name" value="PROTEIN ABHD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09752">
        <property type="entry name" value="ABHD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0734859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="384" mass="42766" checksum="CB8C4D6568C5E987" modified="2020-08-12" version="1">MSAHHKYLDYACASLSHNPLFFPQGFFGEGWGDVHIPSILEKRITDHHEKYAVRLIDSMDLEVIKSSPLKLQKKPTVTISGRFKSTLRDGDVLLPPESQQAYFELIVPESMLDRSFMSIDGRGKSLVVILPGTGEHGCIHRRRTIAEPLARSGVASLVLEGAFYGKRKPKTQKGSKLRRVSDLPILGIATIEETKSLLTWFKEHYGFDHVVVAGSSMGGLHAAMTAALCPFDVGVASWIAPPSAVPAFTQGLLSRSCNWQSLHEREDLAVIDHLLSNQVDYYTTNAEDEIAAQVKKRLAAFLSITNIENFPTPRRPDAVVFSQATEDQYIGDNAMQWENLRRRWPGAQFRRVKAGHVSGILFETQAFVQTIQDVVQVLQSSRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X5Q1</accession>
    <name>A0A6G0X5Q1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_008346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000101">
        <property type="protein sequence ID" value="KAF0735134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X5Q1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005414"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0735134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="115" mass="13510" checksum="06C5E0FC2205CBC8" modified="2020-08-12" version="1">MAIATFFRNLNPFKRSRASQTPVKQHDRGEKNKRNDATPPCTPPSSHEYKFVLAQPIVPRVAAPVEIPREYLYQRFNTVGGKKVPFTRRHVRLARRKMIVYEKIHENQAYYQATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X5S5</accession>
    <name>A0A6G0X5S5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RxLR effector protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_008223</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000100">
        <property type="protein sequence ID" value="KAF0735311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X5S5"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026307380" description="RxLR effector protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0735311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="104" mass="11701" checksum="12E400D965CA406E" modified="2020-08-12" version="1">MRLLLALALLSLTAASRTSAERRLHAPEGRSLLQAGPLIRAMANPPSKQFHPEHFPVGDSRRPVTKGNMYLNANPNYLRKEATRREAERKKKNESQSSGKRLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X5Z9</accession>
    <name>A0A6G0X5Z9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="2 9">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ae201684_008091</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:33180"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="2 9"/>
    <dbReference type="EMBL" id="VJMJ01000098">
        <property type="protein sequence ID" value="KAF0735401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X5Z9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013194"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15898">
        <property type="entry name" value="EFh_PI-PLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08558">
        <property type="entry name" value="PI-PLCc_eukaryota"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000039">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF36">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16457">
        <property type="entry name" value="PH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="172"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="209"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="PI-PLC Y-box" evidence="12">
        <location>
            <begin position="517"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="11">
        <location>
            <begin position="624"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="464"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="473"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="483"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF0735401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="777" mass="87645" checksum="78CA3B93A321E651" modified="2020-08-12" version="1">MEAPTDEKGGDEIMPAPISIKGTKGQLFKEKSKKLKCCVQYPSDEPLLKGEVLKKVSRGGQTATRKYFVTPDLFCLKWEATGKLSMLKDKIRRNPNTIDLASIVRLQSGVTTAKLHRMDSKTSLARGRCFSIILAFGKTIDFICSDDEQYGRWYNGLLSLVNRLRTARLQDPEKAFLYQIWIHGDVNHDGMLSRSEVEKVTHTLNHALKSKPELRRMFSDSDMDHDGELDFDEYCNLMIQLRHRPELDTLFDPRANGKSFLTSEAFSAFLTWNGHSSDEIQTILESFTVDDQCTRPLFRRYIASSWNSWAKPAMLALHQDMTMPISHYFIASSHNTYLEGDQLQSNSSVNMYISALLRSCRCVEIDCWDGDDGQPIVYHGRTLTTKIKFFDVIKAIQANAFVTSPYPVVISLENHCSEAQQVIMADMMVLTFGDQLHIQDPENDVLPSPESLKYKFLLKGKQGAQVDEKAGDSESDEDDEGKDNDSPSKKSEEIKRRPSQALPVKKKSSVAPELAAICYFKGVHFHDFEASKSWQCNQMSSFSESKTKKLATDQKLAFVELNRKHVSRIYPSGMRVDSSNYNPLLGWTTGSQLVALNYQTSDLPMRLNHGMFSQNGNCGYVLKPPSMLSEIGTYRRAIQSVTVQVFSGQQLPKPQGEKKGEIIDPYVMLDLVSDGNSIQKKSQTIQDNGLNPNWNFEAKFDVGLEAACHILVLTVMDYDLDRDDLIGFAALPLTCIREGYRTVPLHAGDGSRTGPYEFASLFCHFSFEELHEEEGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X662</accession>
    <name>A0A6G0X662_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_008104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000098">
        <property type="protein sequence ID" value="KAF0735414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X662"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017377"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45125">
        <property type="entry name" value="F21J9.4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45125:SF3">
        <property type="entry name" value="NO-APICAL-MERISTEM-ASSOCIATED CARBOXY-TERMINAL DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0735414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="225" mass="25940" checksum="42C927C748B57B05" modified="2020-08-12" version="1">MGSGRKWPTEEDLQLCRSVMHASQNALTGSDQKGPVYWEKVFQHFSEEFPGRTMCAIKNRWKSAIQPATNTFCGHYTTISSAPQSGCGEEDIRNAALELYESIQNSPFEHMLCWEYLRDKPKWNDIKRVPLDLEAAEANLTQLKKRPMGVDTMKDIVARDNDKKRKYDELLEATKARNALIAEQNRLFLFSIKDADIPDESRAFFAQRRALAMKEIENEMKLNDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X6U5</accession>
    <name>A0A6G0X6U5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="7">PARP</shortName>
            <ecNumber evidence="7">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_007735</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="7"/>
    <dbReference type="EMBL" id="VJMJ01000093">
        <property type="protein sequence ID" value="KAF0735727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X6U5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013556"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013557"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990404">
        <property type="term" value="F:NAD+-protein mono-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070212">
        <property type="term" value="P:protein poly-ADP-ribosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01437">
        <property type="entry name" value="parp_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.142.10">
        <property type="entry name" value="Poly(ADP-ribose) polymerase, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050800">
        <property type="entry name" value="ARTD/PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004102">
        <property type="entry name" value="Poly(ADP-ribose)pol_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036616">
        <property type="entry name" value="Poly(ADP-ribose)pol_reg_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036930">
        <property type="entry name" value="WGR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008893">
        <property type="entry name" value="WGR_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10459">
        <property type="entry name" value="DNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10459:SF66">
        <property type="entry name" value="PROTEIN MONO-ADP-RIBOSYLTRANSFERASE PARP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02877">
        <property type="entry name" value="PARP_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05406">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00773">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47587">
        <property type="entry name" value="Domain of poly(ADP-ribose) polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142921">
        <property type="entry name" value="WGR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51060">
        <property type="entry name" value="PARP_ALPHA_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51977">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="WGR" evidence="11">
        <location>
            <begin position="207"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="PARP alpha-helical" evidence="10">
        <location>
            <begin position="326"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="PARP catalytic" evidence="9">
        <location>
            <begin position="456"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0735727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="678" mass="76446" checksum="7CF13720C5C3B7DF" modified="2020-08-12" version="1">MGVATLRVIYANDTWAILQGIVYLSRFVWFAYAAIWIGNEWNLRLTSVSTSACAWSTVVVTLLLVRFVGAVKIVFAIFSFFFNIIDMDEMLDVTICTVGAYGMYIVIPLVLSISTDVVAFLHRKAAARNERHLASLDCDGHFSRVEAAHSAMAFWLWKTLGWTIISATSSKQKVGKKSKTDTPKTVEKAITPPLDGVYAKNVPKSANHAVYRDYDVMLNQVHISSYTSNNKFYRIQLIKTNPATYDVFSGWGRVGEDGDYKLWCSGADLKTAVEVFHKKFKDKTRSNWKDRRNFAQIPGFYDMVELDYAALDAAKSSPQFGDDSVPSELPPKTQKLIEMIFDKDMFKNELVRMNLDPKRMPLGALSLKQIEKGVAILNSTQATLAEANPSIFKLEDLSAKFYQFIPHAYDRSTIPPVLETPKQLEEKYHMLATLHDIAIAQDVEKALGETEPVMKHSVDLKYAELNSQLDLVTPDHPFFETIRAYIANTKRKCSCPKHGMQLVDIWEVRRSDEDKTFSKFDATPNHRLLWHGTNVAVVAAILKSGLRIMPSSGGRVGKGIYLANMLEKSRQYLWGSQFDGQNVACVFLVEAALGQMNEIHQDDTTITKPPTGFDSVVAKGKTHPNPDEDQVITLDNQQVRVNAGKWIKSGVESAFSFDEYLVYEESQQRLRFIVTFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X760</accession>
    <name>A0A6G0X760_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_007841</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000093">
        <property type="protein sequence ID" value="KAF0735837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X760"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005976"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052050">
        <property type="entry name" value="SecEffector_AnkRepeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586:SF3">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0735837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="525" mass="58782" checksum="6B48AF2D018FCD22" modified="2020-08-12" version="1">MTEPAIVHVFATQGLVALISEFQDGVYEDMRALLRVAEELEGWHDVLDQPVDDCRRMIDALSTWYGTHGTSRLEALFRIRPDMKRVVLESAAYAGAIDVLEYLHARHLQLFSFYTMDIAAAHGGLPTVKWFQSHRLEGCSRLAMDCAAKYGHLDVVLFLHTHRSEGCTTQAMDKAARNGHFDIVIFLHTARTEGCTVRAMDGAAGNGHLGVVEFLHLNRLEGGTSDAMDKAASGGHLDVVRFLHEHRNEGCTRKAMDEAASNGHMSVVEFLHSMRGEGCTTRAMDGAVMNGHLEIVNFLHINRTEGSSHKAVEHAVCKGNIQLLKLLWEERNVEIKLWDLIRAARAGHLQVIEYVYSRQPKAPWRDVMDAAGAWGHLDIFQFFQRMGLMSSTAAMDRAAFYGHLEAVQWMHFNGKQGCTTRAMDGAASKGHLEIVQFLHYNRSEGCTMKAMDEAAMNGHFHVVQFLHENRHEGCTPRAMNSAAARGYFEIVKFLQENRSEGDIPSAMNFASFRGHLDIVKLLHQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X7I3</accession>
    <name>A0A6G0X7I3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_007712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000092">
        <property type="protein sequence ID" value="KAF0735929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X7I3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017696"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0735929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="454" mass="51484" checksum="7679FB90A3CBBA50" modified="2020-08-12" version="1">MAEAVFGLSAQSTMIAAMNYVPSCMWDELCLLLATDEGLHDEMNTVCDILEGDSPDEASDTASPSKAQHGFHSTTPPATPTLRPTKPRKRPHFDVRQRQEMILLRREVDILRKHLSASQTKVKRPLEMTKWEKAAKSECMEKNRSIQENEQLKEAVHQQATLIQQMEKLCNKKMRLTDDAEAWQNYRLAAHESLRVAAIHAIADRQYRRMQNAFIQAGVFGCTKDLFRARVTQQDSKYVVMELANHVTLRAPFRVVSSAAWRIIGGPDAYMMTQGWIETTDFVDRHTVYSRAMLNQPDGTAVHSNIIRKRYVEEDREVIVSRSVLEDELVPHMSKGAVDNKCLWFEVEPLPSHPTTHCSLTCVVQMTVDPTAALNVPAIDVQAALETFMQQMSLTVDTYEPKTGTFHIATKSLEHLAVPHPIHFSLDRGRMFLTALEDEINRAVRLDNHLPLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X8S6</accession>
    <name>A0A6G0X8S6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_007428</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X8S6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014638"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014639"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005942">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016303">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035005">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002420">
        <property type="entry name" value="PI3K-type_C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000341">
        <property type="entry name" value="PI3K_Ras-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF14">
        <property type="entry name" value="LD28067P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00792">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00794">
        <property type="entry name" value="PI3K_rbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51547">
        <property type="entry name" value="C2_PI3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51546">
        <property type="entry name" value="PI3K_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="208"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K-RBD" evidence="11">
        <location>
            <begin position="318"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="C2 PI3K-type" evidence="12">
        <location>
            <begin position="454"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="PIK helical" evidence="10">
        <location>
            <begin position="687"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="9">
        <location>
            <begin position="940"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0736409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1127" mass="128290" checksum="5616BAAA175CB694" modified="2020-08-12" version="1">MWSLGMTIYEILSDGLPFRGFSPQEIEEEIQLDDGERPEDPDDLPIELHPLWEKVQECWRVDPNDRPSALEFVEFLETRYQDVLESDGASSGIGDYPVTQDEPIENPTTDDMLDIGQIAKNWRPVVGVEDSNETMALRCAIYTIYNQVRQTKIPINLDGPEFCFDNDEWLAYKTTIDAKSPVLQCVVRLPSYFHQVESQTHNRGFNRSRVITGTLIKFGEIKKRYTIRFFHLEGNLLTYYRKAPQLNGATLEENNMASLVMGVTNLFEVSALYPHESAPWTFELVTTTRTWILAAESEQDYLMWIEAICRLAPFYSINAKYRRMFQLTNPDITAAQEIRLVLLSSYTVEGALEHIFDHVSSVAKTVARNYKDYALKITGARSYLFDLQQKLCSYQHVRSCVFPKRTLRLTLVLRSELRGPELLKALSLPQRSFDDKINSPSPDIKGQIAKSCDFGIPLRFSINRVVNIPSFVMIMKESKKLLERRPLTHGHCIVKVELFNGGVLIDAPIETNPARLKPALGQTLSALWDTSRSYETKLRLNSIPKSARIVLTLYGVKVNSWGIVSSSMRERILSTGMNMFDSHGFLTQGDQYIQLTADMSKYDCGAVPHAVDENKPLIHIKFASHDAQVGFNWSSSLDITSPQENKFYALDAQLRESKQGNLIRSDSRGVNFKNFVNKFKFSKSSSSISDQSLSRSSSINFRDYFVENPLGNYTPNEKKMMWTSRHEFVDYFNALPHVLSCVNWSNPNQVNEILGMLPLWSPPSHPAAYIRLLDKEFANEGLREFALQKISTMADATFSCFLPQLVQALKHENHHVSPLAKLLMARAIKNPNQIGFDLFWAIKAEAHSPQYRERFGVLLITYTEICSPQFRSILEVQDKLFSETGELVSIARMVKHFYQTGKTKEEIHSAMRERHAKLNDILPPSLLLPLDSTIEVGKIAVQKCKITNFSHAPLWLEFDNAEEGGDPVVIIFRSDEDVRQECLVLQLIRLMDELWRDLGKDYAIEPYKCVSTGPTTGIVQVFRHSVTRAAIQRRIGGMIAWKDDRSIMSWISANNGDSHSYMTAVELFLRSCAGYCVATYVLGVGERNNANIMMTKEGRFFHVALRNFLDHPKNLVSYDASPSGLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X9B1</accession>
    <name>A0A6G0X9B1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA dimethylallyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_007058</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the IPP transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000088">
        <property type="protein sequence ID" value="KAF0736608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X9B1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018281"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00185">
        <property type="entry name" value="IPP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018022">
        <property type="entry name" value="IPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00174">
        <property type="entry name" value="miaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088:SF89">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01715">
        <property type="entry name" value="IPPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="399"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="401"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0736608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="429" mass="47871" checksum="71581F4CE52A3D9D" modified="2020-08-12" version="1">MNKVLNKILVVVGTTGAGKTKLSVELAKAFNGEIVNSDAMQMYKGLDIATAKVTQEEMQGVPHHLLSCIDPVDDCTVVEYKTMAMNAIHDILSRGKVPVVVGGTMYYTQSILWKAQLIEDASGSNGEDAPLDIPSDVDEAYQKLVEVDPEMAQRLHSKDVRRVQRSLEVFYQTGTKHSELIAKKEDDSNETLFDACMLWVDCDRPVLHQRLDSRVDKMVEDGLVPEIESLMAHIKDHLAASPIPLGLKGISQAIGFKEFQPYLAAKEDTTNPDVAKVLEECIVNLKTGTRQYAKRQITWIRNRIVPRNIPVYKLDTTNVNAWTTNASTPALAIASAFLKNEPIPFEACTAETRDTDSKKVKNICEPCGNREFVGLAQWNEHLRSKGHRYHLKRIRLLESGQRFERGPPKKPKEPKTPDNEGIDSVPAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XAB0</accession>
    <name>A0A6G0XAB0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FDX-ACB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_007045</name>
        <name evidence="3" type="ORF">Ae201684_007048</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000087">
        <property type="protein sequence ID" value="KAF0736891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VJMJ01000087">
        <property type="protein sequence ID" value="KAF0736894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XAB0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007535"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070042">
        <property type="term" value="F:rRNA (uridine-N3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="entry name" value="Ferrodoxin-fold anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019446">
        <property type="entry name" value="BMT5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF26">
        <property type="entry name" value="FERREDOXIN-FOLD ANTICODON-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10354">
        <property type="entry name" value="BMT5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00896">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="Anticodon-binding domain of PheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FDX-ACB" evidence="1">
        <location>
            <begin position="240"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0736891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0736894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="321" mass="35842" checksum="23020C898157B6AB" modified="2020-08-12" version="1">MMMVGNLTNLGLVGTTAKASVLIVGDGNFSYTCAFVRHIVAQDDTVLERIRIVATSLDTYDELVSMYPGAAVHVQELEAHNVRVLHGINATKLEMHKDALQVERFDRIVFNFPHYAEGGNKRNKINKHRQLISQFFQSATSVLAHDGQVWVTLCAGQGGTPEETIVRPVGDTWQVAQCAASAGLILMHVHAAPTDALSKLGYNSVGHRLQEKAFRTQESLTHVFCLEALGLEAYHALSWSRDISFWFDDQFTEDKLMDVLESVYGPKVTIKFDKIDEYTSDDGRHARGYRLELSSKTMALAKEYVNAKTDEVVDVLDNHAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XAV2</accession>
    <name>A0A6G0XAV2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_006442</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XAV2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011168"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="421"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="505"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="1020"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="1089"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="673"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="678"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0737267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1163" mass="129224" checksum="6A891B42BAACB453" modified="2020-08-12" version="1">MGCSPSSMRYDSAQVAILPQFIPFTKCVTMNQIELLSEKLRNSTKSALFTLDDFNEWLAVGPYLQVYLRYIFDSLKSTPTSSRVHVMDFLAAMVVCTSTCPSITEKVELLCTLFTHKYAPTLKESDIAIIMLSTINGLKKVTIGLEDTWNISGKTTQDIAKDLTTASCTYMIGCTPNMKSVILREDFVAWCLEYKPVLYVLRHFIPGDILNPTSVLAHMPFYGKVSSQAKMYETLLDEINPVGNEQIESLLQTTATIKIQSMWKRHRAQQVLEAKRHTLLSRLNFAAAKIQDYVKKKRNFLTLMQRAAMERMSLNGALLTFGSGICVGTGDLTEKLPRSADMVAELKLQSVHTRRAFMSSSCTFVDTNNGWMMWGQCLPMHIVDTKSTTFLHKFPSHIDLKVDIASVACGRGHCLLLDKDGMVHSWGWHDHGQTGHGSSKVFSVRNGGASYQTYYDERTGQMIPFLDKPLKLPYFTGDVEQDAVPIPIQQIAAGEFFSVALSTDGQVYSWGEGSDGQLGIGVDYAFDVGYVDKRLEHSAFTFTDEPKAIPTLSNVHSIAVYGNRCTALAKDHRVFEWGAWKRLLGEEVEPSFVPQEREGVKSLGFYKIATGAEHTIAEGASVWLRLPQKETNACFVMLAEHACSMDTVRQLKNPVQVVALDFNFDDFQDDQADLPRPTSLSRADQDTRMSSISSTAESVTDSDIERSIDELLDQLWVNRAQEVIPSLEKMKCMHPSMKALQWPQAIKNGSMSYDDIIDEIMIDIAGRVTCFKLCQPEGFYFELIMGDTIVFEVPVCPTSTTRRITYRGIWAPLASISSNPVDGIGLDNRIVFTRFSPDDLIIKTTLLREDNILDCISASLAQKVIALQEAGAIAVVAGFDFHGTAPFVVEIPVDQGLYIPVVLLEMPHFEAAHASIVQCPDAEARLFHRTDNTPRLIRSALQHGASGVLLQQRQGQDDVCAFDGDLSKGDPFIYPHPFDVDAPFVGMVSFSHGEIIRNATHLDLTNHMVVAAQIQVEPRGHFYAWGCAANGRLGIGAVTNTHLVDGFDARTDTPYRCAKFPVVVPALCGRDIVDFVCGSAHTLARTTSGRLFTWGRGSAGQLGHPDTLDRYVPTLVTRFAYEVIVEIAANDVCSTVVYESLPTERYDQRRKEISLLKAAKIKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XAY8</accession>
    <name>A0A6G0XAY8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">4-hydroxyphenylpyruvate dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_006496</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="10">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 3/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the 4HPPD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XAY8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010624"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003868">
        <property type="term" value="F:4-hydroxyphenylpyruvate dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07250">
        <property type="entry name" value="HPPD_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08342">
        <property type="entry name" value="HPPD_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.180.10:FF:000013">
        <property type="entry name" value="4-hydroxyphenylpyruvate dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005956">
        <property type="entry name" value="4OHPhenylPyrv_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041735">
        <property type="entry name" value="4OHPhenylPyrv_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041736">
        <property type="entry name" value="4OHPhenylPyrv_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01263">
        <property type="entry name" value="4HPPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959">
        <property type="entry name" value="4-HYDROXYPHENYLPYRUVATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959:SF1">
        <property type="entry name" value="4-HYDROXYPHENYLPYRUVATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009283">
        <property type="entry name" value="HPP_dOase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="VOC" evidence="12">
        <location>
            <begin position="77"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="12">
        <location>
            <begin position="248"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="419"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR009283-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0737326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="464" mass="51018" checksum="C07A011E21A8B8E0" modified="2020-08-12" version="1">MPGSPTKKATSPTKKVTSPTGKVTSSKQAAAAAAPTSTSKRAAQSPRRQGSPKKMKLVGYENFQRHNPKSDRFTMHKFHHVEFYCQDATNVSKRFGWAAGLKLVAKSDQSTGNHAYASYVLQSGELTLAITAPYSRKNQKEGYVPPNPAFNVDFAHEFCAKHGLAVRAMAISVDDAVQAYELSVKHGAVGVSAPQTVKCDKTHTTAVISSVQLYGDVVLRFVSGDFKGRFLPGYEDVEGPEVGIGMQRLDHAVGNVPNLMEAVEYVCGFTGWHEFAEFTAEDVGTVDSGLNSMVLANNTELILLPMNEPTIGTKRKSQIQTFLEQNEGPGLQHMALKTNDIFHTMSEMRKRSHFGGFEFMPKPSESYYKNLPKKIGDAFTAEQYKQIEQLGLLVDKDDQGILLQIFTKPLGDRPTCFFEIIERVGCMEDIGGRLEQAAGCGGFGKGNFSELFKSIEEYERTLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XBN4</accession>
    <name>A0A6G0XBN4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_006660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XBN4"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0737500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="99" mass="11356" checksum="447E6D20FFB1B06D" modified="2020-08-12" version="1">MKCVDRSLTRITSLEFAHAGRWRRRDLSRGFGDGLRRCRRSHEAPRDLKTPRVDVGGRRARRRPASGTSAGDTSTKTRSIDTEDRTVLLSRLRRIPRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XBZ1</accession>
    <name>A0A6G0XBZ1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_006333</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000083">
        <property type="protein sequence ID" value="KAF0737666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XBZ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020423"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505:SF79">
        <property type="entry name" value="PROTEIN SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="300"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="10"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0737666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="487" mass="52989" checksum="EB79A8AF17C4BC63" modified="2020-08-12" version="1">MVTITSTSGIFLLFCVINVLNYVDRGIIPGAPTQFQYFIMDTLQTSMTEQGFYLGLLASSFITSYAVFIVLFGYLSITMRPFRLIGVGLLVWCFALVLCGVAQPTKSFGLLLFGRILSGIGESSFQCISPAFIDDYAPASTRTLWMGIFFTGTSVGTAIGYGYGAYFAHSSLGWSFAFYLEALVMLPLALLCLCSIPLRYDIPGHVGTLLSPGRAHLPTEVDHLLVKNGNNTASTTSSTVMDSDGESISIINETIQVLCNPIFLLTVLGSSAFTFTISGLGVFGPLFLLGLGLFDTETEASMMFGSLVVLSAIIGTPIGGYFLDRFAANASSPRRQYYALILMTVLMAIGVVFCLLAWSFLPSRPLFLFFITISLIFLFATPSCTAVAVLLCVAPSRRNFAVGISTLLVHLLGDVPSPIFLGMLKDYFAPHCGSVEIDGEILLNPDCRRDQDGLRLTFLFPMLWLLWTIAAWTSAIILARCRLPRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XCK8</accession>
    <name>A0A6G0XCK8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_006259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000081">
        <property type="protein sequence ID" value="KAF0737765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XCK8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006058"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37558">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37558:SF1">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="150"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0737765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="199" mass="23253" checksum="305DCEB62F2DF373" modified="2020-08-12" version="1">MDPPAKKRKTQVRFDAETDLDLVKEVLAQNPYNKGFSKKRAVWDSDAASLNIDVDGRRCRQRCALLSNAYAQKQKEMHKASSVEETITEMDELLSEILELREHDTMLRTSDQDEGAAIRKEEMKTVGDRKPHNNLQATMIAYMSERDVKSREFEDRRLTLEERRLEIEERKAAHEAERFALEKQERLALIKDRDFKDIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XCS5</accession>
    <name>A0A6G0XCS5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="14">3.2.1.58</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Exo-1,3-beta-glucanase D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">Ae201684_005995</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Glucosidase involved in the degradation of cellulosic biomass. Active on lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="14"/>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0738000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XCS5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016177"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF34">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 16" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="18">
        <location>
            <begin position="118"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF0738000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="433" mass="48848" checksum="C712D3B83C1B0F34" modified="2020-08-12" version="1">MKQDVGNSKVDVRFSVVIVRRILWFCLPQAAVVGFCVLLKIAMRPDPPNYHMSYGITERHVKVQGVNLAGWLVADYEVTPSSVIYQGVPANVSALGEFAVADWYKNKNKKAEMDAKFKTHRDTWITEDDIKAIAAAKLNTVRVPVGFWITGTNYTESITNDPTNWLPLRYSMFTAGSADYLDKLIKVWAKTHNISVLVDITAALGAQNSKPSSAPVTSGRDFDLAQNKLAYNATFDLVKFIIKRYKDDDAFLGIGLLNEPERTPSPTFSQRELFGYYRIVYPWIRNLTKRAILTTQSFGDKQHKGPGPLITDNDETMMTFCVWPEDRTLAFNHWQEWHKVKTNVTAFMNESELATLKDDINGWTGNPLFIGSWNAVKNFSSSVDTATWAKKVLDVVNLAPKGWIYSNWKNDGKNTIPGWSFKDLLAQGVQLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XDA3</accession>
    <name>A0A6G0XDA3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_006139</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0738161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XDA3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001219"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0738161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="133" mass="15209" checksum="9EAB5285C87CF965" modified="2020-08-12" version="1">MADTVLCAPELLTLITSYQHGVWEGLHKELQDWKALFKQTDHKELWRSFQLAPAYGLHSLKDPRFVLHHAIATHHPVDFICRVMQQYPSRISTAFFELASRHLPLADFSLVYKEALALGVDVPGDHRAPLQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XE23</accession>
    <name>A0A6G0XE23_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_005822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000077">
        <property type="protein sequence ID" value="KAF0738262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XE23"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009273"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031139">
        <property type="entry name" value="RPGRIP1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14240">
        <property type="entry name" value="RETINITIS PIGMENTOSA GTPASE REGULATOR-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14240:SF5">
        <property type="entry name" value="RPGRIP1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="54"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="120"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="397"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0738262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="870" mass="100217" checksum="DFFF5456DB27F3FF" modified="2020-08-12" version="1">MQDWHDKYDRLRDEHMGLRRKYIELQEEIKRQATKIRSSQSFEIVDGKSQHEHIQTLYSENQALTTKCRALELRLARMNAKIDESKKGHKRRLSVHVGVQVNCTMDSLDSKTDDKVGPLIEALRHRLDELESDLSRLTAENERLTAIVSEDPHATQIESTMRESTYEMTLLENKYEDIQAQLRSAQVIHNQSVAQMEKLMADNLEMKETISRFKGFEGEVEIRDKTINNLRQEVIMLRNDSIRLHEAIDQLTSRPFNDANTSLQSFMVQIGDLECQVDILNAQLDNERQHTKVLEQSKKVLQSRVATLQAQLETSVQTKVALRLEVEQLRVHHNMASLKLRLFENPADTLLTTALDYAAKISFQPSEIAFLEDTKQSMKTAFSSTMQKMRVTTSMEMANYDRRVSILQELNDDLQDELRRLEKQFSSEIDYLKSKLNQAEQTNIGLKREMAKLFSKRKQLQYAAKPLLEGEIDITELQIVLSDLEVLPTWQNVNLIAICDYGDYVTQLSPVVCPKSAPLNFAISYICVVDDDFFASPYIGVELRSIDDYQETLLASGLLSLETLFSSSTGNADLRLEFFHPISGCQVASVAARLRLQYPVDEVYRAYSTPDTKQVTPFTSEIIVVTLLSVYWPKAPLNDWGSIKYNILGYQGVVESVQWTSSYMAIPHASRQFSLQKSARLIEFIKTYKVAIEVDKCGIAQVPLTLSSPFLASVALDRDDNIVGRLCLEIHCKKFSVSKNVEHYLAAMQVQFQAQENLVDVLRFLLYTDARFVWYRNQSLHNVPLNGPLEVGEFKCYLESLEPWAKHVCTSLLDTSKFKWHPTWLQMETETRDCFQSHVQQKSWTEAFDKLRKPTWPHVRRILHNLMKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XGR7</accession>
    <name>A0A6G0XGR7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_005003</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000064">
        <property type="protein sequence ID" value="KAF0739437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XGR7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017057"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF67">
        <property type="entry name" value="TLC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="7">
        <location>
            <begin position="91"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0739437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="338" mass="38417" checksum="CFB1A31A06E9EF94" modified="2020-08-12" version="1">MSGKGKTSSTKKVPKPNAFLDWLLVSLVAAECVVICRILPQDLLVMLGGLIVLVAIAVWITKASFRAVGGYISRNFLKHLGDPLRKEVTMKKFCDQSWQLVIHASMTVLEIIVLREENWWNDTTSLWNPNSPTCDFPEQKFLTKLLYITQLAIWIYTAFSCKFLEEVRKDYLVMMSHHVVTIALVAWSFAMGFLPVGVVVLIIHDASDVPLDLLKMANYMKVEDRKGFFITETLFVLTLSIWIYLRVYLYPVKLLNTTLFEARGTCCTPEVAYDFSVLAPNPGPPLWLPFNLLLGSLYALHLWWTYLLLKILKGVFSSNVHEHAEDEYEGASDSGKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XH19</accession>
    <name>A0A6G0XH19_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_004708</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000063">
        <property type="protein sequence ID" value="KAF0739526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XH19"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010562"/>
    <dbReference type="OrthoDB" id="78296at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1350:FF:000003">
        <property type="entry name" value="Cation diffusion facilitator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000005">
        <property type="entry name" value="Putative Cation diffusion facilitator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF52">
        <property type="entry name" value="CATION EFFLUX FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="7">
        <location>
            <begin position="58"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="8">
        <location>
            <begin position="259"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0739526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="350" mass="38330" checksum="1ED3665397A97896" modified="2020-08-12" version="1">MSALSQYGAVSLDIKRAQEQAGRPARSAVAHSLIHQQEAGEARCLPEAASQKVQLAITSSIVINIILAIAKTYAAIASGSLAVLSSLVDSILDLTSQALFWFSDRYMHTPNENYPAGRRRLEPIAVVVSATLMGMAALEVVQKSVSTLIEGFGGVLPELDMSILTVSVLCVAIVVKLMLWFICGQIAHVSPSAAALAQDHRNDVFSNGVAVITSLVAHYHSKLWYFDPVGAIAISIYITLSWVATGKEQVERLVGLQADQDFIDRVRAIADAHHPQLKSDIIRAYHFGNNFLVELEVVLPKDMSVQESHDISLALQIKVEALDEVERAFVHVDYQARDYDEHKDPTIRHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XHS5</accession>
    <name>A0A6G0XHS5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_004576</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000058">
        <property type="protein sequence ID" value="KAF0739875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XHS5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011867"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0739875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="39222" checksum="DA5CDDDA7730AFAE" modified="2020-08-12" version="1">MVHVKISKNNGFLEYKEAEIDMTDTTLSTDEIKMRWAHAIYAEEDLFTVEGPHEVKLYHMPRGDDADTTDPALLLSWVTTPGSQWVLDIFARPLITSAIGSAINIETTAVNSPRVVITRTTASPSKPTHGSKYEPYLHVGTWVPLLNSRARRASSPVATTAGGFIGSVIARTSGAHLQSEYEDLLQTTHRAQETLRKFAAIGKPVTTHSIHTTLLPLAMACPSAISRYGPHVLYQGVYNNLLESEMQRGFVQAVRIWFSFDNEHTVEVTKRNGSLGLKPVRQQDGWIVVQALPGSPCALAGMPDEEVFLTHVNGVDVSPPQCPATSDKARQSNGHVSWAGNVVPLVEKCETCVFTYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XHY9</accession>
    <name>A0A6G0XHY9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_004618</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000060">
        <property type="protein sequence ID" value="KAF0739844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XHY9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010299"/>
    <dbReference type="OrthoDB" id="64267at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0739844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="220" mass="25236" checksum="A981A08AB275B86F" modified="2020-08-12" version="1">MTKGSDAQDLVQLLNKSLAKENGRLARLGATSSEREKLRLEMRFNMERDREKRLIEMLKQEQNAMAKGPGSRNIQDINHQRGIVNGKPSIKHKVEQSCRETSNQQTHMPACRLNRTPVQEAAFLSYMTQKLHKTPHQHKSTMKTLTTANVLAHTKSEQNLLVQKCTLLKQLHAIVSQQQRLLQDDQMTVRSSVSSFHSCEPKVHRPPLSYRYVPFNTLDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XI94</accession>
    <name>A0A6G0XI94_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_004442</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000055">
        <property type="protein sequence ID" value="KAF0739997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XI94"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015608"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22696">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22696:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="819"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="59"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="107"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="615"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="659"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="140"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="626"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="643"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0739997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="873" mass="96776" checksum="DB03D73A36CD8478" modified="2020-08-12" version="1">MEKKMEKMVHNNVQLLGNRIPKAKRVETILDMARVQHEKKRRVNDEEDDVNTDQIALSRVAESSTTTVPSGSSAPSESIYQRNPSQGGLTWAVQRPTGFAFNSFANLDPQQRFNGPRNLEQMKPAPTPALTTTPLEKASQAPSISSGTERLNNSSPGVDIVAEAKRRPVSPPKSQEVVIVESTPPKAPNSARTSTSNEKSKALSAISSSFKSMCFSTEDPVTSIDVTPDGQCIIAAFSNGSVRLFDVNSTCTEERFGYLLGHLDEELNAQMSASVVRVKVTSDGCYCFVGCRGTAPKVLMAIHLDKFRHEKDNDEDNLTKYFHVDGKSRGFADVSANTSPAGAPRSYFIITGLGIAKYRLWKFQEIAGKDPTWTCLREFSSSSNTALIAAFSPLSDSSVCFAGIGSDTNLKIFRFSSQTTVDSSSETSQEMVPNTKDIIYIKGNFAYGIANAGGFYRICLSNTSHRDTFDLDASRRTSRTASFVEHIYATDDGIHVIAIGDGVVYYATTDGVAKTGMYLMHMISTAISATLVPKYGIPAAIYVPNHVPVQEPVMLLTTNAEEEKDGFLTMDPIKKLQRVMARGKPSSGLNCWVCGSHSTLHWGVKSTKTPVNLAIQDAPSKPVPKPVEKPKVVREPRPPPPQQSQQSQQSQQNHNSPANQMTKFEILDLKETVENLEKELGMAQKRVSQVKNEADRRLRAELQLRRSWKKQQREYEAQLDTANQTMETLRLQNATLQTKYKEAKAKLAHETVKHEQENGVRVQYDQLCNQVRDKISRVDDHQKILEQTTKTLLQVIQRNTQALKNDGAETVLEVAKTECVVCRDKAANTAVYPCGHLCFCEEDGEKYKNHLRHQSHCPVCQAEMISLLRIYAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XIM1</accession>
    <name>A0A6G0XIM1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_004369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000054">
        <property type="protein sequence ID" value="KAF0740131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XIM1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003369"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="1">
        <location>
            <begin position="60"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0740131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="273" mass="30245" checksum="9D50B760A1788EF8" modified="2020-08-12" version="1">MVDPPTETMDVLYAKWNAPFAAVFTETANKSVTIQAASELHRHMELDSATSVLEVASGAGIGSLDILKYLESSTAPSKSFRITDFSPAMIELAKQNVNPAKYEFPVDIELANGQDLVNVTDGSVDRYIASFVLQMAPDPEAMLQEAYRVLEVGGIAGFVIWGRPEESGWFTILHNIEPDAVTNWNNFYMGQDIPKLRETFKRIGFSSVLAWTKLCVAEKWSAARHADYVASRNPKQDKDAEAAFYAKVLQASQEWLDSGKPIGLETYLILAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJL3</accession>
    <name>A0A6G0XJL3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_004116</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000052">
        <property type="protein sequence ID" value="KAF0740379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJL3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019543"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF57">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="2">
        <location>
            <begin position="41"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0740379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="235" mass="26367" checksum="33DE22FC6B0C43F1" modified="2020-08-12" version="1">MGVEGKAKHTAWKRILRWETQRARIEATVADPATANKVTDRAKGITTTLSIEDEENITIWVAQLRADGVPISNLMLKCKALEIARDVGLSPNDFKASSTWIRGFSKRWAISMRAKTRSGQANYEDGERALAKLTSRLGKVIEEHGIEDIYNADQTGINYEYLPTHTLNATGAKSVWIKCAGRAKDRVTAMLLADNKGIKYPLFLVLKQPKSKIKEVVQENLIHRNGFGIRTWDVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJR9</accession>
    <name>A0A6G0XJR9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_003995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000048">
        <property type="protein sequence ID" value="KAF0740618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJR9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009197"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF76">
        <property type="entry name" value="CALCUTTA CUP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0740618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="259" mass="28424" checksum="22BF984971155F56" modified="2020-08-12" version="1">MVKVGRAAAVGVSAIALAAAFVYWNTRRPQRKKKWLTLKNLALNREWVSICGLVFQVDANVVGPDGIYGDIGGHDATVAFSGRLYSYAGANSAEDAIAASLDSDIDDPLTESERDQLKAWMLTFKSKYPVVGQLSDLYNEPRWDALRAELETATGATKCPLGFGTRHNVDFATKTTKMSDRWILFSGKRYDVSNSKSFDAESPFAMYVGHDITYALAIGSRDAHDLDISLTDAPPLTFAQQKTLAQYQHAFDSSLPVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJY8</accession>
    <name>A0A6G0XJY8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_003976</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000048">
        <property type="protein sequence ID" value="KAF0740599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJY8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004588"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046959">
        <property type="entry name" value="PRK1-6/SRF4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48007">
        <property type="entry name" value="LEUCINE-RICH REPEAT RECEPTOR-LIKE PROTEIN KINASE PXC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48007:SF4">
        <property type="entry name" value="LEUCINE-RICH REPEAT RECEPTOR-LIKE PROTEIN KINASE PXC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="468"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="762"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0740599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="790" mass="87695" checksum="C07E9509F2F8F692" modified="2020-08-12" version="1">MAVAKSKKNKAPKTAVPVGCSREEIVIQRCPDRNGSFACILSQDADKTCQIEPTGGTTGSFRQISGEYLTLRIYRPKRTKTLKVEYVPQGITNFEFYKVRRLEMHDIVFPEGLKYLRFKFTNLPPYPSDKFMNITLPKSMEALYFDNMVIDSLDPSEWRNVPLKTVYVHRLLLLLLLIGFSSFFKTTVQSFDRAVFPPSISTLQIRYSNVSTLETSTLPTALKAMNLEYNQFSTVESIPMDNLHDLSYLILDGNPIHTLGERSSFPSSLQNLSIADCGLSDISDKFVFPPNLVSLDFSNNHLESFPLAKLPKSLTTLDLDSNPLKEFNINDLDVLNFLKKLDAFDATTDNVQCNTSYTKTIVRGKIYACVSQNIRVNIAETKSQQLISKTKISTSTTVFIVVLACVVAAALVLMFVFRVMKRRRSRLANQSELDSFDESTKSSMATFELSKPPREIEPAAKFAKGEGEMTKPTASSGSVVSISPWHDPTFINNDATLAAFRLADDSINNLIPIMGNYYSGVYMGQRVMLVALPLQDGEAIAHLLVRTKHPKLLTFHGFVHGLADETLVVIEWMDGGSLDALLCKSLLLGFMQKIVIALDVIATLVYLHDTVGSSHCHLSTHTVWLTDAGRAKLSLVSGVQPSETIWQPETESEEKSPSTDVYSFGVLLLTLQRQSVPSSHNIEAARSLPIEDDMEILSIDWFRLSCPDKLRTLASQCLQLEASRRPSASEIHTAIRAMMDEVLEAEMASDVQSTVLQLTVLESLGPPPSSTSSDNPNNAAVGNDQVQQVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XK85</accession>
    <name>A0A6G0XK85_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Myb/SANT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_003836</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000043">
        <property type="protein sequence ID" value="KAF0740795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XK85"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019315"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47072">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47072:SF4">
        <property type="entry name" value="MYB_SANT-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0740795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="232" mass="25985" checksum="A0E17385343FE8D4" modified="2020-08-12" version="1">MPQLKSRNTSIREKFSLLWRMANASGMGWERTRSLVVCVSTTWDGFLAGKSEEMRRWKNKLFPLYELCETLYEGTLAKGNHAQSSASITITRTAPIDDVTSSTSLQDAVQDAAQANVVEPFSRRIASQETPPKRVRQSAASVLAAELKSQSESISKELEIFANVMKGDAEAGSCVVEHAIEKLQDEFEDVLEENEFLHAIDVLMDSTKAKIFMKLKGPIREAWLRRQISNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XL24</accession>
    <name>A0A6G0XL24_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_003834</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000042">
        <property type="protein sequence ID" value="KAF0740952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XL24"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002810"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF159">
        <property type="entry name" value="LD03170P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="78"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="296"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="520"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0740952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="814" mass="93363" checksum="689FEA56D569F9AA" modified="2020-08-12" version="1">MQKQKLRRSISASTERRRVADIRHSFTSMAASKSSRSSKTLGKQQTQNRPPSQLDNDNANKNQSTHEDEPVKERKVGKLDLVVEEICTTEATDVKGLITLVESYVKPMQEAKHPIMENTAAAVFFTTLHKLVTLNSTFLEELMQVTIQEEPGNDVTERVADLFNRYIPLFTKVYTEYAKFLDDFSPLVNEYRTQSKEFTAMMDQYQRQCGSNQNFESFLILPIQRIPRYSLLLQRVMEYTQKNHPDLASLEQAVESVGKATQLMNETLQQKEKMEEVLKIQAQFAGQVSLFTLDRRLIKSGVLVKLSTKRKDKVMIHLFNDLLLYSDILAMDTFHARRTVDFHSKACRVDATLPASYSKLYSTESIDCGFMWSEYDFDIKGGILRQYCGGVVTKTLNLSGAIVVRRPDKRSSYCFQISPSTPAPTTGKMSPLKVASKMMDKNRWDDQEWLLCAFSNEQLAQWTQAIEKSASKALKRMSSAVRTRSMDETLASTTGNPQINDIDLDRLDFLVYDDHKAERYRHHILKEIVRSEESYVECIGECIRVFVQPLMLREVERKRSLEHNRKLSLQRRLSQMSMKKHEQLKKTFTLIGLNKRAGMPQGLVNSIGHENYTKKSLLDADLSILFTRNSKTHVKPDVNSMGQIYTLNQQLLDHLTRHLKETESYINPVHRGAIFNAYALFQMYSSYACYHDTALATIESNRFKSMLEEIQLHMDEPTLHRLRTYLNMPMESTRTRSTGSTSRVPGPETSNKEVWSFNCPISSADITLFYVEYKVNGLEHYDNNCGMNYLVITPTSASESMKSSPPITPLQLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XLW9</accession>
    <name>A0A6G0XLW9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_003145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000036">
        <property type="protein sequence ID" value="KAF0741459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XLW9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007178"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0741459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="604" mass="67789" checksum="ED59439B5DEDDF3D" modified="2020-08-12" version="1">MITTVDFTKCFCSCAGPLFSKKYLRPHRTNGSKVLRCFPHCCPEHTESPFCASSLAVSVTGSLELIEKCRVFLRFEASYEPGVVCGGFVDALAIEQSMRSESNPRGEWIPTQPVAVENDQVIFEFRAQADGGWNYRWLGGSSTQQRRCWHYIKAYVCYPSNRPDRLRVIAVVRSPPFVVMSYRRACKSCQKKSNAEPILSATHREACECEGMYRLTDSALDDIISSGTTERIILPDLGSTIHTIQYRNPREKEYHLAALYMTLKFAAISPAVAEELSIVANKLTGTGNKEIWLPIATASSSSPYEMQCLDIFLALFRSRNSLDVLLTKNAQAILDQNRLHEVYEEWLSVAYDTIVYSALRAKDIAPESYFTALLHAHRAVNPTLFTDNQVVSVGFEAFVAQLREIYLALSYRPPEIPSPDSTLDGLWICALDACQVDLCSLSPSLLTVLRGLSMGMRFHLRLSSKSSLFIRSDIALFSTIWSEFILDGAPRVVRVFPNGESTMTACGGHMYGDYVGLNQYPGPVQICLYCWPTEHEKNRTCYILQVVFQPVKHTMLVCHVQVATSRSLIEQHAWNMSAADRIASFDQHDSTVVMKISAKYQRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XMG9</accession>
    <name>A0A6G0XMG9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_003333</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000036">
        <property type="protein sequence ID" value="KAF0741659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XMG9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017650"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="126"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="255"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0741659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="372" mass="42236" checksum="538ECD3947719B92" modified="2020-08-12" version="1">MEDDDEILFDATTDEDPVQHEQHGNDGNEERIKDLDQKPVVTVDHIAQIARLTEQIRQLQASAAEHNTIRVQAAGENALLQKQLDHQLSVVKHLKQMVKNISDKYTAVQIENRALLAESKEDQAALSQCREEVRQAHDEIARYKSRESPWQETLQRCQELEDAQARLQVECNEWKAQTETLAGVQAENAQLQQSLSDSAREQRIASKRTHHMIKELRHSLKVEQEKNQLEAAQRNDVKVITVDGGSDDMSAAGVIRDMATRLEELLAVNARLKERLQFSQENAQLLAEDLEKKRLVLQQLTLALVAPVEERDEIITTAVAKAAAIESSAVTETLLYVTIKENLHLKRQLGCHKAPFAIEWKEPDGLSFYRML</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XMN1</accession>
    <name>A0A6G0XMN1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_003387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000036">
        <property type="protein sequence ID" value="KAF0741722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XMN1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020858"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0741722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="78" mass="8881" checksum="4681D70DD23BFCA1" modified="2020-08-12" version="1">MSTSYQVRSPSRASLQDDHQERAVSQPTVEIEHQDESYMCANSYGARHISTEKKARPQKKPRTKKTVGDEVKSAVWCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XPH9</accession>
    <name>A0A6G0XPH9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_002659</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000028">
        <property type="protein sequence ID" value="KAF0742385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XPH9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016570"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000104">
        <property type="entry name" value="ATP-binding cassette sub-family F member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001438">
        <property type="entry name" value="ATP-binding cassette sub-family F member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF15">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="61"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="382"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0742385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="596" mass="67702" checksum="1E40A4B7663C573D" modified="2020-08-12" version="1">MPPKNTRGRRGVTKGGKAAKKDPTAESVPVERTLADKLADDGIIATCAHSARQVHANFKDINVLDFSITYFGKVLMESCDITLNYGRRYGLIGRNGSGKSTFMNVLGARGIPIPESIDIYHLKHEIEPTDMTALEAVISVDEERNKLQQEVDELSEKMLDESLADEESEAITNRLTDIYERLDEMDADTAEIRARTILSGLTFSDAMMQKKTREFSGGWRMRIALARALFIQPTLLLLDEPTNHLDMEAVVWLEDYLSKWKKILLLISHSQEFMNGVCTNIIDLKNKKLEYYSGNYDTYVKTKEEKEENQMKKYNWEQDQIKHMKDYIARFGHGSAKLARQAQSKEKTLAKMVREGLTEKVVKEVEGDFKFPNPERLPPPVLMFQDLAFGYPGCPLLYQGVELGLDMDSRVALVGANGSGKTTLLNLITGQLMPVHGNVRPHTKLRVARFTQHFVDVLDLSKSPLEYFRTLFPDKSVEEVRSYLGRYGISGEVQSQVMEQLSDGQKSRVVFAYIAHQNAHILLLDEPTNHLDMESIDALARALNKFEGGMLLVSHDMRLISQVAKEIWLVEDQKIRVYEGEISDFKMRVRKQLKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XPK8</accession>
    <name>A0A6G0XPK8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">eRF1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_002882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000030">
        <property type="protein sequence ID" value="KAF0742217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XPK8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021612"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000032">
        <property type="entry name" value="Eukaryotic peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004403">
        <property type="entry name" value="Peptide_chain-rel_eRF1/aRF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10113">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1" evidence="1">
        <location>
            <begin position="29"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0742217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="106" mass="12126" checksum="D8FB032AD4BF984F" modified="2020-08-12" version="1">MRNNQTGEEVHKILSPAEEKVATNFTDAETGETLEVVEKEPLVEWFANNYKQFGTTLEFVTARSQEGSQFCQGFGGIGGILRWQVDFMEMEYEGESDDDLRDYVFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XRS3</accession>
    <name>A0A6G0XRS3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutaminase</fullName>
            <ecNumber evidence="2">3.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_002194</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaminase PdxT/SNO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="2"/>
    <dbReference type="EMBL" id="VJMJ01000022">
        <property type="protein sequence ID" value="KAF0743139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XRS3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015837"/>
    <dbReference type="OrthoDB" id="2039at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903600">
        <property type="term" value="C:glutaminase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008614">
        <property type="term" value="P:pyridoxine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01749">
        <property type="entry name" value="GATase1_PB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000041">
        <property type="entry name" value="Glutamine amidotransferase subunit pdxT, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01615">
        <property type="entry name" value="PdxT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002161">
        <property type="entry name" value="PdxT/SNO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021196">
        <property type="entry name" value="PdxT/SNO_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03800">
        <property type="entry name" value="PLP_synth_Pdx2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559:SF0">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01174">
        <property type="entry name" value="SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005639">
        <property type="entry name" value="Glut_amidoT_SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01236">
        <property type="entry name" value="PDXT_SNO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51130">
        <property type="entry name" value="PDXT_SNO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="47"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="139"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR005639-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005639-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0743139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="206" mass="22301" checksum="A96C8E159025BFCB" modified="2020-08-12" version="1">MVKVGVLALQGAFEEHVDMLKKVGADAVEVRLPSQLDGLDALVFPGGESTAIAKVAERWGMIEPLKQWVHDKKPIWGTCAGMILLAHSARHAKQGGQALIGGLDVEVSRNFFGAQIRSFEKGIQGPPGYGDAPYNAVFIRAPAIVSVGEDIQVLSEIHDAQPADGSDPSNVIVAARKENILVTAFHPELTSDTRWHQYFVEQVVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XRX9</accession>
    <name>A0A6G0XRX9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">F-box protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ae201684_001998</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000020">
        <property type="protein sequence ID" value="KAF0743206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XRX9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF14">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="F-box" evidence="11">
        <location>
            <begin position="185"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="278"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="676"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="778"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="916"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="963"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="923"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="977"/>
            <end position="995"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF0743206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="995" mass="112747" checksum="3F4821A1A31A125F" modified="2020-08-12" version="1">MDIGSVQVLVERHDAAWTPPARETIYRINSSDDADTMFWPGFPLDQPLWRNLLRMLDEVDVVLALEVQDMALEDSALILEAHLLYVGQQAKKTAWIRTFDYVLQHFEAALVPRRSVTTPAMLADARAAECHVIGCRLHSPSLQAAVSSHFNLPSLFKSLESPLEAIRMNVRPDASYVDRLTAGFTLVLTDMPMNIIWEVLKYLNARDIARMSSVCSLLQHVTYDTVPGLRLTLFPHQKKALKWMLYRESQSNAQLRQLEHPYIVGQWIDPVFGRVAMNCESQDTRGGFLCDEPGLGKTITMISLLLRTQGTLACPTNIMPTESWNNYGLRSSKQSGRTVSADRLRASRASLIVVPDTLMAHWTNQFQLHTTGLNVLFDTSRTVPDADTLVLFDVVVTTFGRLAAHWIHRRPLSTLEARAPERLGRENQVTYADGVEYKALSPFLELHWVRIIVDEGHKLGGSLVTNAMQMLCGISAEKRWIMTGTPTPHVAQTDGLRHLHSLLRFLQEKPYGTDDDKPWLQAIARPFEAKCLKGYLRLERLLNRIMLRHVKADVTTIPKPTYLRTVVDPTPVEYRIYNGVVGVVRGNLVVTRWDPEFPGPLHKDSLLNPANRKDAMTAVANLRLAACGGGSMEVLLSTAHFVETVNYMNDFDMPWERRPIVQQYMRDAQENKCTACEVCRRELQFLMVTVCGHLICANCLEAYVEVHGFKVGMLVPCQVCGAMYDWEKFQELQPGFHYQWSDDERNSAQAAVAAAPHGILNPDEHVWSSSKGLYVLERIQTLLKTPAAELSRPIKCIIFSDFKEHIFRIRPDFTRAGVQHVSFVSGEVNMAKRIKQLAAFRANDNIHVLFMTEIGAIGLDLSFVTHIFLMDEIWDKSVEQQVIARAHRMGATDSVVVEQLEMRGSMEALVRELYSVPPDPTKKRTHDKARKKPAAKPKKNLFSVMNKESMSSMRIYHVLQNARMMDEPTHARQTSALDRDHDDQENAAKRTRRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XTD2</accession>
    <name>A0A6G0XTD2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_001360</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C69 family. Secernin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XTD2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020892"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070004">
        <property type="term" value="F:cysteine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005322">
        <property type="entry name" value="Peptidase_C69"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12994:SF17">
        <property type="entry name" value="LD30995P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12994">
        <property type="entry name" value="SECERNIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03577">
        <property type="entry name" value="Peptidase_C69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026043563" description="Peptidase" evidence="3">
        <location>
            <begin position="19"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="594"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0743701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="626" mass="69139" checksum="618A760724DB4BE7" modified="2020-08-12" version="1">MRLVALGLVVVAAAAAHAASSWIERDRCTAILVGAKVSTSGSPMTTHTNDCTVCDFRIAKVPQKTHPHGSMRNVVLPRGYYPRYVGTDRGAPEYFRENLELDFFNWTDSKSIGQIPQADMTFGYIDGVYPIMNEFQLAMGESTCGAVFASKPVTQGGQALFDVTELARVAMARTKTAREAIKLMGSLAEQYGYFGAAWDADQNDALGEAGETLTVTDTKEGWVFHILPDDTGASAIWVAQRVPDNHIAAIGNQFIIHQVNLTDSDNFLGSANLYDVAKKHNLWDGKSPFDFTAVYAHRRPGESYYYSTRRQWRIFTLANPNLTLSPYTDAFGTDYPFSVETASVLDARDLMRFQRDHYENTPFDLTQGPESGPYGNPDRYSVGENAFAPGTQGKSRSFERAISLYRTTYTIVTLANPVNPNTGFVWFGPHAPHATTYMPIYAKVSSVPQVISKGSLLKFSFNSSFWINALIGNYAGHFYKFAMLAVSTVQLALEEKAYDAQAEVQAKAQSILASQGEAAMVAYLTSSTNSFATAAHEAFVSLFYDLVTRFHDGTIFGNFSKESMDVQAMGYPTWWLEEVGYYDPNIDGLSETSWILIVLAVIGLSVALGFWLGRRNVQQKGYALVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XV93</accession>
    <name>A0A6G0XV93_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_000813</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XV93"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018837"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="72"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0744325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="344" mass="38806" checksum="A513FEBEA68A6164" modified="2020-08-12" version="1">MMNEEWSRETTQLKRLNTLDSDATTSSSREDDSSDNLSASDDYISDDDSDDDEDDALYEPKPRICFESVYAMSTRDKIGEGTYGVVYAATHRESNARVAVKCFDKSTMDLADTVQLLREVDVLRMIHHSHVIKFVDFFDEPQHYYLVTELVNGGDLFDRLARRKVYAEEKVRALVLTLLKTVESLHGLNIVHGDLKLENILLTSTDNDVSIKLCDFGFARHDMNDELTGHWGSTEYMAPEIFSCARYGRQADVWSVGVITYMLLSGVSPFGGQTKAELVTNIQRGHVAFPAIFWRRVSAQAKAFVSTMLVANPRNRSTIQDLLAHPWLQEPAPLAIKSKPRAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XWC6</accession>
    <name>A0A6G0XWC6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CLASP N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_000589</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000003">
        <property type="protein sequence ID" value="KAF0745008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XWC6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007037"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="300"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0745008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="373" mass="41990" checksum="CD2912084E4BD65E" modified="2020-08-12" version="1">MTTALLSTKVAACCETLSLQEAWVFAKKPELKAVRDAFGETPCESNETIVVDALLPLAAPMAENLLPSWHTDTIQTTCALLVTFVTVLGVYFRPFTDQVVVPLLNAGRKMRRRNMDERLANTNLSEWKLVDQMLWQSVETCLDMMSSKSRYDLLPILDHYDACHSVSVQCLVLRQVEIVLGSWTKVELEPYFGHIRDLLHNAMHDRHLDIRMTARGAFSNFCHTWSEHMDELAHIPSPHMLNLLVDCYTRHDISTTNGPTSAAVDMVEDIMVEEEDTQDVVEGKDVVGRVDEVLDVHLSLVMYLLVFLTAPLWSLSLLLVGCLLWPVGISTKAQIGPMPSVDLLCEDQRSRDASDPKKDTRGCGEKQRRIQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XWX1</accession>
    <name>A0A6G0XWX1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Coiled-coil domain-containing protein 61</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_000638</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CCDC61 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000003">
        <property type="protein sequence ID" value="KAF0745064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XWX1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003139"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22284">
        <property type="entry name" value="HD_CCDC61_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049733">
        <property type="entry name" value="CCDC61_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22691:SF1">
        <property type="entry name" value="CENTROSOMAL PROTEIN CCDC61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22691">
        <property type="entry name" value="YEAST SPT2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="315"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="366"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="401"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="448"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0745064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="526" mass="61208" checksum="EABCBAD748C9B759" modified="2020-08-12" version="1">MCFHGVEYSVNIWVQRDELHVQVEEQSLKLGLENDRWGAHFPSLYIEELTKKTGNFKRFHTFVNMLISALNHKSESVFIDLLTYSDLELYRKRKMGKSAPMHQAESTSSMHNNKRYLILTYAVEFDRVHYPLPLSFIENPSPDMLKKTIKRLKQALLDTKSENSPQLDKQLASMQEENDSLRLRLQQLQDMRDNQDDNASLARLKNELQSSITENKELMALYQQLRKESSKEIQSLQTEVDRLRSKPDEVFDDSRYIQRIRQLEKDFDRYKADQNRHKLALEEQLDEATKELTSAKSTIQELQLKNRELLRQLAIQRTKSTPSTHIRSTPHSTPKRRSSEPPSSDSEDGSVKKKFSQSDKTPPRFKRFDPTAYHQERQQKLRARSQSPKPPSPARKPPQSNGYSSDSSAGYRSGGSDYTRRSRAPRNSSSQRENDARLGSPRQPPQARQREAETRYRSPSRIHDEPKDTRYTPPRGRPKPSKQAMKRLSLDDSESDTPLQSFVDIDNRLNALQQFLKDAKQPKKDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XXV8</accession>
    <name>A0A6G0XXV8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UBR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_000333</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XXV8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018152"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF408">
        <property type="entry name" value="OS09G0560450 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="111"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="163"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="218"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="292"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0745305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="501" mass="54685" checksum="7D2638FF126942BA" modified="2020-08-12" version="1">MASPVSRLSLTLAVESHQLFACGDNTYLNLCKSPSPGHDPCDDFIRHATSLMEHFRSLGKSRITSIACTEYASFALVDKPTDLDDNVRQRHAEFSLKKKKANEASEPNEYNHVFSWGRGDRGVLGHGNNESIAVPRIINTLNYFRVTQIAAGRQHVLALTESNGVFAFGHGSHGQLGLGHTSDSDVPAHIDTFDGINVTFVAAGDDFSAALTDTVGSRQVFMWGSGQHGKLGNGEEVDRLKPTRVNALRGVKATMLSCGGSHTLVVAGIDCRMWVHGLNGNTEPPTKKAKSTVVYSWGHGGYGQLGHRDNWDVMVPKIIDEIAKEHINFVSGGTRHSLAISESGKVWAWGQGTHGHEPDHHKKDWTSSATLFPRRIHLPDMHVIGGVAGRGRTFVWGDRAKFHPTERSLRQEYDSLSSESQCSMASASKQLSSNCLRVLYTCGTCHYETVCVVCATKCHAGHSLLLRWTIVDCLSRHCDCGVSGQCMALSTTQEKGATRNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XY87</accession>
    <name>A0A6G0XY87_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CLU central domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_000167</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000001">
        <property type="protein sequence ID" value="KAF0745718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XY87"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015450"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641:SF19">
        <property type="entry name" value="NEPHROCYSTIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0745718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="563" mass="62390" checksum="5CE47CFE6B2503EA" modified="2020-08-12" version="1">MDAPANEASYVRQLYDDLRDGDEGIDLAGFLKPLYFQQHNGFTILDAKAIFDVVKGNFKQQLNLREYGTALTKVAKLRYSSNPKTLARLVTDLHSFRKKARVENYSEAQADAGFDNLRVKLMMVAPLSLLEAYSDTMQQSFQMYCKTAADGGMTDDAFYDFLVGYFISPDYILPDEASMITSAVTSTFATNQLSHHHGTTMGYPQFLEGICRVAQVLHGKLVDGEAGTLRKTIETSRLEHSLKVMFDHMQILPNGDTVKTSSKVPEQQIDTSLDAVLDEIHAQVGSLSLKVRKVLQHHRGATSPEKKTFVSAGSVIVIKDVLAIPDFPPEVTNKIECAVAYQNHGQYEMALSQLHEAEDDMIDLSQYRVLDTDAQLFFMLSRGSILDSRQRDLDALQTYSEALVVADGLPEAHPGRGLVLSCLGTVCFHSGNIVVALKCFDKALTIRETLYGENHVDTATTLNNVACCLHAMGQIDAAVMYFRSALSVFKSGFGISHPRVSVAMKNLATAQRRQTRLEGTADTAKNRPDLKHIIAGSKFQIMAFERPMVPVKTKKKKVSVKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W3B8</accession>
    <name>A0A6G0W3B8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_019130</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000407">
        <property type="protein sequence ID" value="KAF0721463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W3B8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006889"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03213">
        <property type="entry name" value="ABCG_EPDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001305">
        <property type="entry name" value="ABCG transporter ABC superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052215">
        <property type="entry name" value="Plant_ABCG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48042">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48042:SF11">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="423"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="483"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="23"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0721463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="506" mass="55494" checksum="18C232B8C276768C" modified="2020-08-12" version="1" fragment="single">MTVDANYLEVHVEQAAVVYPCTLNWESVNFKVKQGKEEKHILREVSGRANPGQVTAIMGPSGSGKTTLLDILADRVSSGEITGEIEVNGKPRDKNFRLMASYVAQEDSLLGSFTVLETLRYAAQLSVASTVSSKEREARVQEAIDNMGLRSCEDTIVGDIFRKGLSGGQKRRLSIAIELLSHPTILLLDEPTSGLDSASTFAVVKYIANLAKQNRTIVCTIHQPSSAVYNMFDHVMILSQGQTAYFGSPNDSLGHFASLGYPCPQFTNPGEYFLQLVNTDFEGHQDITGITDGFASCELNARLRKSIQQDRVNMASSFIPKEYTQDLRPSGFSQLAMLMHRNSLNNVRNPGVYGVRIVMYIMLSLMVGSVYVYDTKEEDLTALLFYVQAFLVFMSVAVLPFFIEQRSVFNRERANNSLSVLSYVIANFIAALPGIFLIAVISSGIVVGLAGLNSFGYFLLNLFLSLVVAESLMHVLGAVAPHYIIGIALGAGVFGMFMLVEGFMMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W4E5</accession>
    <name>A0A6G0W4E5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription elongation factor 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_018834</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ELOF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000359">
        <property type="protein sequence ID" value="KAF0721898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W4E5"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.190:FF:000001">
        <property type="entry name" value="Transcription elongation factor 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007808">
        <property type="entry name" value="Elf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038567">
        <property type="entry name" value="T_Elf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20934">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20934:SF0">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05129">
        <property type="entry name" value="Zn_ribbon_Elf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0721898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="84" mass="9798" checksum="C491AFC75C6B8BFD" modified="2020-08-12" version="1">MGRRKTSTKKIVTRKKQVVARVFKCPFCSHDDSVQCKMDRDRNVGHLSCRVCSESYQTNINYLSEPIDVYTDWIDECEALHAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W5E8</accession>
    <name>A0A6G0W5E8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_018762</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000353">
        <property type="protein sequence ID" value="KAF0721981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W5E8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014090"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF9">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="13"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="46"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="79"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="112"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="145"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="178"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="245"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="278"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0721981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="410" mass="44610" checksum="D0E37D8B9EEBF864" modified="2020-08-12" version="1">MMNKVKKLFGNTKKEEKLVVAAANGNLDSVRALLGQGANVNFKDQNGQTPLFHAARQGHCEIVQALLAHGADMDIADKMERTPLHIASHKGHLRVVNEFLAHGASVDVKNENQNTPLHAAASRRHYSVAKALLAHGASISSTNTNGDTPLHRAATKGSLNIVKELLARGAVINAKNATSCTPLYRAAHGGHLQVFQELIANGGDIHMKNKNKNTPFHSAAWSGHWNIIQELVKTHGFTVHDVNGYGSTPLHRASRNGQVEMVKQLLKHGARVDVANNDGWTPLHRAASEGHALVVKVLLDHGSPVDAVNKHGDTPLHLAAKSGKIEFDNLKNSSVSSTDKTHKLGHTISSVNGQVEVLQLLLDASAKRLLRNKNGKTARDLANDNVQAWFDNYQEMANKQLLQRISKLWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W5G6</accession>
    <name>A0A6G0W5G6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_019213</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000499">
        <property type="protein sequence ID" value="KAF0721176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W5G6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019508"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF702">
        <property type="entry name" value="AMINO ACID TRANSPORTER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="6">
        <location>
            <begin position="1"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0721176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="273" mass="30138" checksum="F1EF23BECA1577C3" modified="2020-08-12" version="1">MRKLGKLRISSILATCAVGYVVCLFLIVYIVVQTSVVPLVVDAPAVDITSNSVYTVTLLIQAFACHNTALPVYEELRNRSIQRMNRAVFGAISLAFTLYAIIGFSGYFTFGHATLDNILVNFTPEYIATYPGVKTPLLFGRLCMGVALLFCAPLSNWPFRSCLLSVYLRIKNGRQTPSSAATTFEFVAMTTFWQLLILLAAIFVPSVKIPLSIVGSVAGSLIIFIMPSLFYMLQNRPVVSWSNKGPLFMLVLGICIGVLCFGLTILKLKREYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W6B9</accession>
    <name>A0A6G0W6B9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphoribosylformylglycinamidine synthase</fullName>
            <ecNumber evidence="3">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Formylglycinamide ribonucleotide amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Formylglycinamide ribotide amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Ae201684_018273</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the FGAMS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000327">
        <property type="protein sequence ID" value="KAF0722674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018194"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01740">
        <property type="entry name" value="GATase1_FGAR_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02203">
        <property type="entry name" value="PurL_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02204">
        <property type="entry name" value="PurL_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000007">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.650.10:FF:000006">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000009">
        <property type="entry name" value="Probable phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.750:FF:000001">
        <property type="entry name" value="Putative phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.750">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase, linker domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="entry name" value="PurM-like, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00419">
        <property type="entry name" value="PurL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040707">
        <property type="entry name" value="FGAR-AT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055181">
        <property type="entry name" value="FGAR-AT_PurM_N-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010073">
        <property type="entry name" value="PurL_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041609">
        <property type="entry name" value="PurL_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036604">
        <property type="entry name" value="PurS-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01735">
        <property type="entry name" value="FGAM_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003672">
        <property type="entry name" value="PRK05297.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10099">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10099:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18072">
        <property type="entry name" value="FGAR-AT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18076">
        <property type="entry name" value="FGAR-AT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22689">
        <property type="entry name" value="FGAR-AT_PurM_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13507">
        <property type="entry name" value="GATase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01211">
        <property type="entry name" value="GATase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109736">
        <property type="entry name" value="FGAM synthase PurL, linker domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="PurM N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82697">
        <property type="entry name" value="PurS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribosylformylglycinamidine synthase N-terminal" evidence="16">
        <location>
            <begin position="54"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoribosylformylglycinamidine synthase linker" evidence="15">
        <location>
            <begin position="200"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="14">
        <location>
            <begin position="465"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="FGAR-AT PurM N-terminal-like" evidence="17">
        <location>
            <begin position="683"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="14">
        <location>
            <begin position="875"/>
            <end position="1009"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF18076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF0722674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1346" mass="148195" checksum="9A24F22487EA7E08" modified="2020-08-12" version="1">MTSMSRSPLAKKMKSTTSSTLLTYFRTPFWSDHATSTFKTTWTDVLTHVDTESCFYVELEASASPLTADEESCLTWLLSETFEPEKYGAKSFYPATKNANEWHVEIGARLSFSTPWSSNAVSICHACGLTKIKRIERSRIFRFHGKPGKLTENFKTAFLAHYMDRMTEQVYEAPLTSFGVAQQPAPVQRIPIMTEGKEALRKINESNGLGFDEWDLEYYTHLFQQKLKRDPTDVECFDMGQSNSEHSRHWFFGGKIVIDGVEMPETLFKMVKSTLTEANKKNSVIAFHDNSSVIHGAQIKTLAPSVVGQPSSLEERHLTSHVLLTAETHNFPSGVAPFPGAETGTGGRIRDVQATGRGAHVVAGVSAYSVGNLLLENYDLPWEDKEVKYPSNLAHPRDIIVQASNGASDYGNKFGEPVVSGFARSFGMVLPSGERREYIKPIMFSAGVGQLNANHTSKGDAEVNMWVVKVGGPCYRIGMGGGAASSRIQDAKTAELDFNAVQRGDAEMENKMNRVIRACVELGDRNPIVSIHDQGAGGNGNVLKEIVEPTNGHRGGARYEVRNILIGDETLSVLEIWGAEYQENNALLLRPADVELFTTICRRENCPFSLLGQVTGDGRVVLHDALDDSTPVDLELDLVLGKMPQKTFTDKTETPVVRELVFPIDITVSSALDRVLRLLSVGSKRFLTSKVDRCVTGLVAQQPCVGPLHLPLANVSVIAQSHFRSPETGTYTGCASAVGEQPVKGLVNPGAMARLTVGESLTNLVWAALSGSLFDVKCSANWMWAAKLPGEAARMYECCKAMTSFMKDIGVAVDGGKDSLSMAARVESENVKAPGTMVVTMYAACSDVEKTVTPDLKLDGGDLFYVDLGRSKYRLGGSALAQVYSQVGREVPDMEDTALFSNAFNAIQACVRNGWLSAGHDRSDGGLLVALLEMAFAGNLGLHLDIPFDSPKVMTLREQIGVLFAEELGYVLQVPKAHQQDVVALFEKHQVPLASLGRVTADKNIFIQINGRTVVEDSMTKLRDVWESTSFELEKRQRSADHVVKEQEGLKDRTCPPWQLTYEPAPPKPITNRHQHRVAVLREEGSNGDREMSSSFYLAGFEVWDITMRDLVAGTVTLDERFRGVAFVGGFSFADVLGSAKGWAGVVKYHPNVLAQFKAFRARQDTFSLGVCNGCQFMSLLGWVNPPITDELPSEGGDLNPRFIDNACEKYVCNFVTVKIQPSKAIMLRGMEGSSLGVWIAHGEGRAYFPHPQLLENVLDNNLAPVRYVNDANQPTEDYPFNPNGSPLGIAGLVSDDGRHFCMMPHPERTSLKFQWPYKTKVIQDAKVSPWLQMFQNAKTFCEQNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W7B5</accession>
    <name>A0A6G0W7B5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycine zipper 2TM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_017984</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000318">
        <property type="protein sequence ID" value="KAF0723020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W7B5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006180"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026331529" description="Glycine zipper 2TM domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0723020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="25416" checksum="53362E6D1CEC6314" modified="2020-08-12" version="1">MRVVLFLVLALSVFGWGQPVARLQVNRVLRGQLERRWRRKVGNIMEIVGGAAGNAIGTTGSITIGTVTGGNIGTRAGRSGMAAGTRIMGEYMGGHFGGKAGSFLGRQADKLTSAGRQAQAAAKNRKKDQAEALKKPVLYTGGEYQKAKLSRTGSSPALLQRNNASPGGRKPPMNPGQASTSGSKPVSNKGKAPMNPSSASTSGGQSPRHGASTSGTKPAINGGKASASVVKSPINVGGQGSALRKRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W7N9</accession>
    <name>A0A6G0W7N9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_017870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000314">
        <property type="protein sequence ID" value="KAF0723122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W7N9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001774"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026098753" evidence="2">
        <location>
            <begin position="19"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0723122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="164" mass="17261" checksum="EF05EF80C74AC67C" modified="2020-08-12" version="1">MVSRFILLSSLCIGAVFSTIAPTAAPTPASTPASTPAPTPSRPTATRPAVCIKIDVVSTLYLPVTVDSNGDIATLSDSYWVQAGCEGQDWSDVPIAYSCGCDYRRKFNTNSTGYDLDATFWCNVGIVTFNIIPPNPYCTAAPTPAPTQAPTPQPTPAACITKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W858</accession>
    <name>A0A6G0W858_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_017694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000309">
        <property type="protein sequence ID" value="KAF0723352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W858"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005688"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051707">
        <property type="entry name" value="PI-Interact_SigTrans_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336:SF8">
        <property type="entry name" value="PROTEIN OPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336">
        <property type="entry name" value="TANDEM PH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="15"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0723352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="227" mass="26390" checksum="3E16F16CD7E3B80D" modified="2020-08-12" version="1">MSNRLVNVGVDDSLLDRKSGWLNKQGHVRKNWKRRFFVLDGSVLQYFSDDIDSSVQKSKTHKLKGEVLLFHKDTTVRYVDATLSGRDFTFAIDSGEYSLQLQASSLDEREDWVFAVEDAILCRESYTEDERTNKVRSNVEVRSTACHNLTSRWLTRSKSNFVTTFKLHYTIEGAIDEPTLVGALKSFRIFVERILVKGMERYREYMIQNKQEIENTYAEARDLLLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WA74</accession>
    <name>A0A6G0WA74_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_017200</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000286">
        <property type="protein sequence ID" value="KAF0724034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WA74"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014168"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000054">
        <property type="entry name" value="Complement C1r subcomponent"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF98">
        <property type="entry name" value="FI18310P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026070582" description="Peptidase S1 domain-containing protein" evidence="10">
        <location>
            <begin position="20"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="11">
        <location>
            <begin position="46"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0724034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="244" mass="26499" checksum="69F1203EA8506592" modified="2020-08-12" version="1">MRIWLWLLIALAILEEIQADRHPYRPRSPRHPTFRSRSRSNRKKRIVGGSKVRVGDHRYLAGLKGSADEETECGSTLIAPKLLLTAAHCVLDNIKVAAIGTHFNTGHEGGELIEIAEKIPHPKYNGEPSDGYDVAVMRLAKASKITPGKLSFDPVPVGTPLTVRGWGLTTDGGNTSKEMLEVQVNALNDKQCKKSLKIKKWPHSSFCAGGVKGKDSCQGDSGGPLMVKQGKDNFVVGVVSWGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WCX1</accession>
    <name>A0A6G0WCX1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_016323</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000249">
        <property type="protein sequence ID" value="KAF0725171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WCX1"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0725171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="71" mass="7439" checksum="FD44AE59DCBB74CE" modified="2020-08-12" version="1">MCGIVGSVKSELLAARKGGAIQGDGQARLRVESPQLSTAAGERKGSVAGMDRGEGWLLGCPRATPSVDWRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WD90</accession>
    <name>A0A6G0WD90_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_016198</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000244">
        <property type="protein sequence ID" value="KAF0725301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WD90"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010354"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF73">
        <property type="entry name" value="PROTEIN PDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="2">
        <location>
            <begin position="64"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0725301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="402" mass="45640" checksum="651AB41FEF05823B" modified="2020-08-12" version="1">MTKKRMTLHEKNLLRMTWKSQHHSTYAELGVWAAHEFKLLNPPTKSAICKILKKQDVERNDVKTKKNDSSVRFPTIENELSSWVLTCEAKGVSITGDLIKQQAEAFCNVHEIPVQSRLVFTNGWLEKFQKRHGFTSKIQHGEARSACKDAVDNGRKAILDLTAGYNRRDVFNMDETAYFYALVPHRSITRNRLPGLKKSKKRVTIALTTNVTGTDMIEPLFIGKSKKPRCFRGQESQVLGIRYTSSKKAWMNSQIFNSYLDDLNKSMVMQDRKILLLVDNVSSHKLAADLTNVELKTLPPNTTANLQPLDAGVIAAFKAKIKKKQLEYALRQVNGVLSGRQDKLYDVPVIETMSWAREAWKAVSPSTISNCWNRVGIIDVDLPTLSDRILSWNVNGDRHTIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WDK4</accession>
    <name>A0A6G0WDK4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_016618</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000264">
        <property type="protein sequence ID" value="KAF0724744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WDK4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003667"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="START" evidence="7">
        <location>
            <begin position="48"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="264"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="327"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="380"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="346"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="388"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0724744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="433" mass="48740" checksum="825A3A94B67CCF8E" modified="2020-08-12" version="1">MSGLPLPLNFFRCPPLRSEEKGFLQQLARTVAVDVINNSRISNPSMHWRLSSDHGDVHLYEGIDQSAPPGVVSWGSVTHVKASLQEVADLFTCEPSTEGYRNMMHVISRHDTLDCAHLYSITNNDVERIDVRWFALKSPLPGVVLPRDLCNLDVQQPFEWEGRQGFVVGFTHIDMKCCPDFRRSLGLIRMRSHRAGYVFLETNIPGQLEVTHLYQINMGGTLPRWVIRAGMKVRLKNVRNLDRYLREKRLSQVSFLAEAELIPVNDRSKCFLCQAKFSILRGKTQCRKCGEVMCRLCTQVWTILNSGIEVPVTVCTPCSLDPSRMEEERRRGLRAGTPPTYFHPNHTPQRAPTSTESVASSPIVLYIPDSDDDFNFVEDGKLGGYDKPTSSSQKHQGHPWSSTTGMVGAGIGPGQISGEPTAYDWNFRTPPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WE40</accession>
    <name>A0A6G0WE40_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_015906</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="VJMJ01000237">
        <property type="protein sequence ID" value="KAF0725573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WE40"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021162"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd24134">
        <property type="entry name" value="ASKHA_NBD_OSGEPL1_QRI7_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Gcp-like" evidence="7">
        <location>
            <begin position="47"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0725573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="323" mass="35039" checksum="741C7C84BC58C3E1" modified="2020-08-12" version="1">MWRQISTRVHRGPWKGSHASKRGISYVLGIETSCDDTAAAVVDSDGNVLSEVVSSQWEMIQKWKGVVPALAARGHVENLPLVLDEAMRQSGLDGYKSLSAIAVTSGPGLAPCLNVGLRSAVEIAVGNDLDFISVNHLEAHALVPRIAEDLPFPFLVLLVSGGHCTLVLAKDLGDYDVLGSTVDDSVGEAFDKVARMLELGNENTAFHGGKLVEEYAKLGNDRAFAFTEPMKKKQRKDCDFSYSGLKTAMVRHISQLEKPLDEATKRDLAASFQVRNLVIAKPYVPSADRHCSSCHANQIGMRNQQGNDEYSAFGMDGSLARLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WER5</accession>
    <name>A0A6G0WER5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_015734</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000231">
        <property type="protein sequence ID" value="KAF0725883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WER5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005891"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF214">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="378"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0725883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="648" mass="71680" checksum="70F8B74405CFB6D6" modified="2020-08-12" version="1">MLRSLASSCPYATLPANISTVLVKDDTYCKSTDIQCVISRACTYLGSSTPSKNGDLTPNEPIWEAIGSFQSYADTTLEFRRTSDLINVDLMALPDRITNLGIISMTTNFASAYKWPTNLTYLKIFQNGLTSLPTSSLPPKLETLYVVRANLASSEELRNLPSSVTGLLLNSNSYTALTNIDFSALKYCNLAYNSNLKRIYNLTFSDKLFYLELSGLTLDSWTMDAKTYLTLNQMKEATSYMNTPESFGTGGHIGKPTIKFDAAECANYNGIQKELWTGSGLNVCVYGGLVIATDSNKHTTGMTIGIALGVAAFVGIIIFVMMRRRHTKTAKELENVREFYSGMDTPTISNGDDKSAGAAAVGLDLSQLTRVRIDIKHIKAQQKLGSGAFADVWRGTFHDEVVAIKKLHPNRTSLEQLKAFVDEINLMASFESPYIVKLIGAAWTRPLDIHCVMEFMDSGDLKDYLDSNHSIPWPEKIVHLLSIAEGLVYLHSMDIVHRDIKSRNVLLDSTKGTKLTDFGISKEDIQATMTVGVGTFRWMAPEVLQDKHYTIAADIYSLGVIMSELDTQCIPYHEIRNPMNGQPIADSALIGKVLAGEIQPSFTRNCPLWFLDLATQCLSHDPDERPTAMQASHIVRNFIHRSEDGGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WEZ9</accession>
    <name>A0A6G0WEZ9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Ae201684_016238</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000246">
        <property type="protein sequence ID" value="KAF0725273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WEZ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002040"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0229">DNA integration</keyword>
    <keyword evidence="15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="13" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="14" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="17">
        <location>
            <begin position="440"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="174"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="711"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="199"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="766"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="782"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF0725273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="920" mass="103142" checksum="7A75604F931A9FFB" modified="2020-08-12" version="1">MVYSTEDVVEMMQILRDRYGNKSFVGHGRLIDEVTHMRMRHNETPRSYCDRFDLAIKDATNAGIKFSDEQVVHFFLNGLDSRFNTFVQLQSHLLQRTPIDASTLSLITTELLQAYNREQSRSNSPPPTPVDEAALSLRRNHRRKPRFNGPSQSDINNETVCAYCNIPNHTEANCRRKQRDQRQQTSSRSNQRRVEFQPSSTTSLASQTAANTRRNARSTVSMLTLGPHYTLNAFESPASLSAWILDSGASDHFCNDAAWFEELQPFEGTVRAANGIDMPIAGTGSVLLEMNTPTGIIPVTLQDVLFIPNLQYNLFSLSRVTDRGFNSQFQRNACYITREEVVYAQGFKHDNLYYLDIANPLPTQSSSTPHVGLSLLTNSATPTQADLWHARLGHISVKYTAKTCQYTDGIELDDCKHAFCESCLAGKQSRLPFPKRSLSTTSEPFALVHSDICGPMRHPALRDRSWYFITFTDDYSRYGFVFFLKNKSDALQCFKEFTAYCRTQFDLPVRCLRSDNGGEYFSNLFSEFLLENGIQHDATVPHTPQQNGVSERMNRTLVECARSLLHFCKAPLRFWAEAVSHAMYLQNRTFSASTPGTTPFEKLWKSKRDLGNLCIFGCEAYAHVESHQRTKFASKTIRAMYLGNEPNVKGYRLYTSSPERIIVSRNVVFDETKSFFTEEPSADESPVSQLIDEIDDDDELSLRDEALALPAAPPASTIVTSAPNEGTPIVPRRSTRIRRGNPRYNVPPVHVPQSTLVEPLPPPTRPIESTTPTPSITEADTSESLVENTPPQPLDDSTSSRVEPAPQQTPAESPADIPLPSSPSHGPMSRTDTPAVTPEFVPVMMPPPTSTDSTSFDEDVLCEQFESLALSLFRLRPVANSDVDEHQLSKQHRLLVALALQSTGLPSNIRQAHASPEKHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WF78</accession>
    <name>A0A6G0WF78_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_015665</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000229">
        <property type="protein sequence ID" value="KAF0726000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WF78"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009526"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
        <property type="entry name" value="FYVE_like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="START" evidence="7">
        <location>
            <begin position="242"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="367"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="601"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0726000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="631" mass="71403" checksum="32546E33D0E1EEF9" modified="2020-08-12" version="1">MDTVTPSQDSLLVPSLSRNITNDPRRPLLWMPSTCSTARGNRGESPELFLTVHFGITRCDVFVALCASNWCLCSTRRKSDQVVSFNEPTKKYRPEPFDVCMTTFPLPRNFFRCPPLSPREVAHFTTEGEQDCVRAIRYANIVDGPIKWTLDSSFENTQIYVGKDPQAGPQVSVWCGVTEVQSTIEEVARRFKTETTDDYLEFCQTFAKDIADASNLYTVVRSTPANPLRAIMIKWFVLGSPMPFVVKSRDYCFLDSCHEFSIDGRRGWVQSFKSIMMPCCPDLQASLGVVRADIFAGSVFMESTRPGYIRVVRTWHSDAKGMVPRFLVSRSIKLRCVAMRDFKSNLQESSVRNAMPPLLPPSDLVSHDSRARCFLCNKGFGPFSTKKNCRVCGEVMCRYCIRWLRVKGEKLNLCVMCFMVPAKMDQVPRVNDSESEYIPSLDDSILYGSFGGESEEFDSFYPSSQIQHTITLPIGKLPGPSSVDGSLTVPSVDDSAFYRHGATEDPYFFIPEDDFYHDDGHLNYDMANHDVSTYDIINHDTIDYNNGNTIPVHNMVHPVPIPHNIPMLTPVQHNVVKMKMNATTDVNYRNDMNVLPSTIHVSKPMTEPPSQVRNDLIPLDGPWDLSKPMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WGA7</accession>
    <name>A0A6G0WGA7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_015710</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000230">
        <property type="protein sequence ID" value="KAF0725940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WGA7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009511"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15710">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PRAJA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PX" evidence="6">
        <location>
            <begin position="21"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="201"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0725940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="28671" checksum="A963D3B30F13C265" modified="2020-08-12" version="1">MAASVKVSQRLERAQQASLDAASVQSTQVCRVGKDIYSAVTFYKMDISFPRTHNKWTIRKRYSEFYKLRRALALLLKHDKKQSNQRQALPLPLKLLEESLTPAFPRRHLRADNVAIIEERREALQTFVQQLVKIMCAFSPEAKVDTSLKSLQATLKDFLAFPDEQLHMDAKRTLAILALEDVVVASSTNVIETETSTSDCCSICLGEWNEAECADMHIVKLPCAHVFHEECVMDWLAVSSECPLCRTEASNPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WGC1</accession>
    <name>A0A6G0WGC1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_015658</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000229">
        <property type="protein sequence ID" value="KAF0725993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WGC1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013877"/>
    <dbReference type="OrthoDB" id="73680at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051707">
        <property type="entry name" value="PI-Interact_SigTrans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336">
        <property type="entry name" value="TANDEM PH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="245"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="3">
        <location>
            <begin position="372"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0725993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="540" mass="61535" checksum="70EB2DAB95690D51" modified="2020-08-12" version="1">MAMMRDSDMSDISVMLESSRSLMGEHDHAARTPPDGLRAAQLQKVHEDGVTIGSLDSDVMLQMTDTDTEDDMYRSTPRKPETDKPTPFEEAKSPSRSGYVRIFFESSDFTSSKMLLVEERTTVLEVRKIMATKMGIKERKFDDHAILMVYVSGKGSSMSARTLKDDEFIFQVQEAIHSERQSLPEITNENSGPVRVKLRHRAHQTLKFVFKDVRGKPIDLEGQLGISDNSSAQDTVFLLPQKLGRGQRCGVLKKASLKDANVWRSRWFVLKDDNLFYCKSETNQREITAIPLLGTSIVKQDALVPFCFDLQTKRRVFRLCANSDDERMAWIHALHREIRLAAENAYLMQAESRIVDEAVTACERKQERTPFAVAGVLGHHVLRKMFRDFMVSESVSSTILLDTWVECDLFQRNAYARFDAHRLQLAGGGNGSFISKAQDEWDHVKRLLHQYIPAAIEAGAELNEADVELCRLSLHDNQKHRRLSIAMNQNVSNNNVADYPPPNLFLAIQQDILRTLEKGPFKRYIAGHGYTRILDRTIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WH32</accession>
    <name>A0A6G0WH32_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inorganic phosphate transporter Pho88</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_015342</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000216">
        <property type="protein sequence ID" value="KAF0726454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WH32"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020257"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012098">
        <property type="entry name" value="SND3_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28112">
        <property type="entry name" value="SRP-INDEPENDENT TARGETING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28112:SF1">
        <property type="entry name" value="SRP-INDEPENDENT TARGETING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10032">
        <property type="entry name" value="Pho88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0726454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="22914" checksum="88412B9C14805397" modified="2020-08-12" version="1">MKLPTLETIKSVPPVFISLAAVLLSRQLLDSENPVHVWVIRILYMISQLACTGVLAYLYYQSSNSKDPAMVTVKEDLGFGIEGDKVEKITVGEHDKRAALTEMQKAALGICITTFIHLNWGFTPPLVVGIYNAPYTLYQTPLVRVLFRGERAWGKLQRPWSDPMSSIGKKFEQWNDTFVNALSGESGNGPKKSKKEKKDKKKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WH53</accession>
    <name>A0A6G0WH53_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_015291</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000215">
        <property type="protein sequence ID" value="KAF0726477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WH53"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004863"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0726477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="463" mass="52764" checksum="5CF22D6B564F83C6" modified="2020-08-12" version="1">MASDDCQRVVTSTPLLRYICDFQHGVYHDVLPFLQFSVVESQNLLQYAIQAQVEIFATLQPWLKEFGLARLDRLITTLPFMKSILLLYGARVGDCVVLETITRIDGVQTAEILTNLLNVAMASNHIQVIESLYRLGYTPDNDYYIGHLFCGMGEAIAASNMAMAQFLERELSKVGQATSKAWFELDQLDQRRLETSLKQLVDANEGDLFSWLLKTWSRFASQGQLNFVRRYWRGVALELSKWTLLASMEDPERPLGMQFSEDLHLALKIPSLPAVQWLLERGCRVNFIHITNASRAWRSRNEMNVRIDIFDHLWTAWLAQGATADAMETVLFVSNQSAWQAHSVQAIDLVWSKGGKPPIQNVINAARYGSSLEAVDFTFHRLKHSMPVDKLMALEMDGLLAAIRSNKISYVEWWLGHVEIRNQDLAEAVLRVMKYNTVDLGIRVLVESKCKAWPVESHLLEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WIE0</accession>
    <name>A0A6G0WIE0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome b-c1 complex subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Complex III subunit 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_014966</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the UQCRQ/QCR8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000204">
        <property type="protein sequence ID" value="KAF0726976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WIE0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021216"/>
    <dbReference type="OrthoDB" id="57605at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.210">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004205">
        <property type="entry name" value="Cyt_bc1_su8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036642">
        <property type="entry name" value="Cyt_bc1_su8_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02939">
        <property type="entry name" value="UcrQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81508">
        <property type="entry name" value="Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0726976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="87" mass="10338" checksum="3B650A5136EEE48E" modified="2020-08-12" version="1">MAKGHHLAQGALKTWWSKYQYESGRITRHLSPNEQRPVDYLIRTAPQKALRKVQDNFFPLVPSFLLLWGTVAWAVDENDRFHRHHWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJK7</accession>
    <name>A0A6G0WJK7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_014653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000198">
        <property type="protein sequence ID" value="KAF0727396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJK7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016104"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0727396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="566" mass="62858" checksum="3474448ADB4B4CC3" modified="2020-08-12" version="1">MNASIDLSATPMTHALLVDCDYSGRHFQDTTMFKIYLVDTSMTSMMSIAIQTMIGLRETTHLATQVGATVVSLTQLSKFGLGPDEPPGAEWFYGLTYDDATAFHETYHDGVSASNEYKWRIQSTNESLLIAGLSGYYRGSTASQTNMLRFLIDMTGSPVRDFVVDMYPSLAYWKDAWAWVQGLVILTIGVRVGFTIVVALSIAFTTSKSTAAAHLPDVFPTIKRHIHVRSFLLVLAFVCDGFWSIHEWALTVGFIRYNLLPLFVLGENIRSDLLMLFLVWTDGVASALRVGIWPAITVVAYILCYTHSSAIVAALSSQQVEDATAEYFNQAYIANTIAYASFGMNEWNQYVLPPEEPPLWLVAREFVWFIAPCIGIAGLLVVYKLALVAMAKLGGERYRVHTADDAENFKVSVAEMAAMRGVPSVFLDNFIPERHGIPTKGLLTLPPPRFLFSKDAFQMPKTLLWSSGWLILDHKFVVYADDLPRIVASVLTGISFGQAYCCSIRTLDSRRTLVPQLMPVPVAELSWRSLLHVSVEALWVKNLHMMTKTCATLPPRRSSSGAPIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WKU4</accession>
    <name>A0A6G0WKU4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_014140</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Folate-biopterin transporter (TC 2.A.71) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000185">
        <property type="protein sequence ID" value="KAF0727912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WKU4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017197"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039309">
        <property type="entry name" value="BT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585">
        <property type="entry name" value="FOLATE-BIOPTERIN TRANSPORTER 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585:SF5">
        <property type="entry name" value="RNA-BINDING S4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03092">
        <property type="entry name" value="BT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="394"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="431"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="503"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="543"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0727912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="582" mass="64884" checksum="82B5C741B1D42A2E" modified="2020-08-12" version="1">MEQAKPTKVWLLDENELQMSSRTAETYSIGGETMDYCVIMDKRTSEMSAFSGTHDEDVDDVDFGALRPGGALNLLSLEAFGLLSQYAGVGILMGVFNALQYPLFQNYLHMEGYQSASYRVLISLGWSSKIFFGILSDCLPVFGYKRRPYMVLGWAMCGVCCLMMAITPFPAPYYGSKELKGIPTSNMTADQLKLINLAAPTSASFFIVMSMLGSLGYVMADVAADAMVVQYAQREPAAIRGRVQTAIYFTRDSFTMVPMLVVAFCMNDYKYGGSFSWSIGPNVVYAGLTVPCFLAAYTAFALMVEEKVDHVHITEYMQNAWLLLQKRVVWQICAFKFFNGVFFGYQSTLNDPISSIWVKVQPLVATSFSILSQLFRVVAMFAIGKYALNWDWRWAIALSTILLVVFDTAWHFLAIWDIYRNQYFHSAMNSLEAFPSATLFLFGAYILVEVVEEGNEGLVYALVATCNNLASPLSTVVAKTIDSFWDARLSDIQRDDSTVRWQITYSFIMAAAFKLGSLAFLVLLPRQKEYVQVLKRTGSLSKLAGGLVVFLFLLGYAYNLTTNLLSIYPSTSCLRIAGGKGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WLI8</accession>
    <name>A0A6G0WLI8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_013972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000181">
        <property type="protein sequence ID" value="KAF0728146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WLI8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018808"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="229"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0728146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="243" mass="26847" checksum="D1F96BE9D731476C" modified="2020-08-12" version="1">MEHLSRMKISKEMLASWRDPNRRESFDGSRSSGSSSIPSRRASLADEPSPAILQRKSLHPCDDEDDEYRPIVMDDYSPLDMLVQPKPDWFHRSLHLSKDSQITATTEGSSVPAALLDQADVLSSDNEGNGNNDDDDGSDVLDLAMQPVYIPTARMGGGPKASTKMDLVMDCLISNQVRADAAEDDQFSMDLAFQPLHISSKSRKLRHEDPTAAMRECLAANQRRTRKMSQSGSSIRSGSTDSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WNJ1</accession>
    <name>A0A6G0WNJ1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Winged helix-turn helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_013357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000171">
        <property type="protein sequence ID" value="KAF0728925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WNJ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019585"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025959">
        <property type="entry name" value="Winged_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13592">
        <property type="entry name" value="HTH_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Winged helix-turn helix" evidence="1">
        <location>
            <begin position="3"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0728925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="144" mass="16450" checksum="DC66E977352E3E93" modified="2020-08-12" version="1">MSICQDLKSNYGVDVAVRTMRRVLVRMGFKHQKGRTRFYLAETDANVAFRAKYLRKKITNRCENGCPIQPEVYLDESYCNLNHSPRKIWINETKLRKTKSGKGPRVCIVGAGILSATPNGRMAAHFVEDSLSMWPSNSQLKQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WPK7</accession>
    <name>A0A6G0WPK7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Transmembrane protein 230</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">Ae201684_013030</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Involved in trafficking and recycling of synaptic vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasmic vesicle</location>
            <location evidence="5">Autophagosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
            <location evidence="3">Secretory vesicle</location>
            <location evidence="3">Synaptic vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Early endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus</location>
            <location evidence="6">trans-Golgi network</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Late endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Recycling endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TMEM134/TMEM230 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000166">
        <property type="protein sequence ID" value="KAF0729283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WPK7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014975"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044234">
        <property type="entry name" value="TMEM230"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008590">
        <property type="entry name" value="TMEM_230/134"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15664">
        <property type="entry name" value="C20ORF30 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15664:SF6">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05915">
        <property type="entry name" value="TMEM_230_134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0770">Synapse</keyword>
    <keyword evidence="9 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00004603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00007743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF0729283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="110" mass="12226" checksum="A4ACDB06A65C6D84" modified="2020-08-12" version="1">MVRDATKESFVGVADLDPCTHAVSPISRWARAKQRFPIRTAMAAVTLFTLGSVLLYVSTRFGLDDEQRGLSFFILGLITFIPGSYATTQLYGAYKGWPGYDYSQVPSYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WPU1</accession>
    <name>A0A6G0WPU1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_012912</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000164">
        <property type="protein sequence ID" value="KAF0729411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WPU1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018339"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0729411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="184" mass="21339" checksum="FCE4F5D5DD2FA89E" modified="2020-08-12" version="1">MEIHSQFHIVFATLYDVANSLWDFIIETSYATSVLVTCEPVNFFHDRLIYSHGVNDDNGTDLLRIMGMFIEDDRIVLTLTKIAHELFPIPPGQARTHGYGWLVFERVTDTIIRVRHSDLHLAPMTSHGVETLDEMGHLFGIPRRFGETSECFLERIHTAAESTYLEKYPPWIRRFQQYVSQRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WPY6</accession>
    <name>A0A6G0WPY6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar membrane-associated protein IML1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_012929</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000164">
        <property type="protein sequence ID" value="KAF0729428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WPY6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008914"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027244">
        <property type="entry name" value="IML1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055213">
        <property type="entry name" value="IML1_double_psi_beta_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048255">
        <property type="entry name" value="IML1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179">
        <property type="entry name" value="DEP DOMAIN CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179:SF8">
        <property type="entry name" value="GATOR COMPLEX PROTEIN DEPDC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12257">
        <property type="entry name" value="IML1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23013">
        <property type="entry name" value="IML1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IML1 N-terminal double psi beta-barrel" evidence="3">
        <location>
            <begin position="41"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar membrane-associated protein Iml1 N-terminal" evidence="2">
        <location>
            <begin position="148"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0729428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1163" mass="132231" checksum="B80F871FBBC44752" modified="2020-08-12" version="1">MNRRRWTRPKNTPAPSPPPSTKDVVDDPITKTVKKSKQRAIFKLHVHGLEFHGGEELVLNPDALKQDLSFPEDDDHVMEIYTPNDPDDSRRHLLLDIPSVNELKAKKPVKGTMHLSLLKDTAAQFQLQVLQDVVVRFVEKHTVEVDFVEVTMKDQFLSRRDVWYLQHALIGKAVYVGKMVRMHGARLQVMELVHEQENVTSGVISSRTRFVFRSKSSRIFWLVQVSPELWDTGNNGDLYADELIRMVSLLVDRWQNTSHGVTIILFARNYYDNLPPPHSIYYSPAIVQDDDGRWFEDFYKVISYGKATLDMSAELISLKAEVNAFPHLCGWELGASTLTCKGGNGRPSSAKEGNVLEAINLVLNIYEKHYLDRDLNLSGQNLALFTAGNGMFRVNQRLSEMTEQRMMDNGIGFDCISLSTPPLTSVPRFFIKGYHRSKGQQAAQEDYQPMWFSVRFSQHSSSSKFTPLPVCRLFAPPVGTPSRPLAFLLTQLQLTNHQTLQVPESPPTPLTITLPPTPTPPIDLDLQLQRQKLHIFSDDYDDDVFTVRSTSISDERSPALQCGTPPLHSLGAKGRKIKSFVLSPELKPAMKSPMNPLFLPPPQSRSYQSPMGSPPTLASPANRPNNLMARHGSSSSMIAPSYIAATNSNKRRWSQVYRYEMLGYDLDFKSLCTPALLPLTTDYMPSPQDLKWNITESFYTVTLPDQSDYDASSPSLFTTHRELVLEMVAQRFSQDFQLMEESHNGDTTVYKLSMGHRIHEITYYESRQEIVVKILQQSQAKQLSRVAYPYSLWSPLTSAFMAAKQDFRYPHHGDYAWNYLDSLICGHSDEMTDNIKYKRGLYCILPPLGLSLMSESDRQHAIDEFVDRMNRLLEYIRSKAKDGGQKVDVKIAPYENKVTRRVKQGDVKIPLAAADAPLQQQWLNIHLDLEVVPIQVFHVEIQWLVCRSTLVDDFILGLQRRAKQFNLDMIAMPENCGATTMDVHPLIYPVYFPLNTSSEFALVEYKLTMEFNFCLEGIHRIPNDMLTSEYMKPFKAPSALNQRTMSGKSLVPQRTYRQFIHRSLSCFVRLTEVGVIWISSRRMHSPEMQALFCQLKIVIRMIAVMTEMKNEMKKPGIFHVLPDDNSKKTDGGPTLIVTLPRIQGDLSTPSSKADQPSNLATAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WQ93</accession>
    <name>A0A6G0WQ93_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">CSC1/OSCA1-like 7TM region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_012831</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000163">
        <property type="protein sequence ID" value="KAF0729563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WQ93"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011793"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF5">
        <property type="entry name" value="RE44586P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="462"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="613"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="670"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="694"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="10">
        <location>
            <begin position="20"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="11">
        <location>
            <begin position="193"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="11">
        <location>
            <begin position="352"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="408"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="762"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="762"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0729563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="786" mass="88707" checksum="2AC6E5E59356F449" modified="2020-08-12" version="1">MDSNGVETNVTVDIHPSDTIKTSMSIYFVIFGASWIVFLWVQRRKLSIYACRNENIETASVAPDTTTLFGWIRPTWNMNDDAIFESCGLDTLVFLRVLKLGRKLALFGIVLSAALFPIYATGTNPDEASGQRKDIDPLERITMSNLSSGEARLWASVVAMYLMTIYAMHLFRTEYRYYVMRRHQFLSRDDPQQYSILINNLPLNLRLPSTLKYYMDYLFPGDVQGVTVAIECSALEKSVAKREKTRNSLEHAMAESAQSGVRPRYRPKKDLQHEYDAIDYFTEKLAKLNRKVQDKYNDIMEKLQKLELECTASGVDKTAFAAPSTAIDARERSETTVALDEALHRHLKDGVMRRSAFVSFTSLQTAQIAQQILQTENPMEMDVTAASHPEDIVWENIGRSKEEKDYWRLISTAISTGVILFWTIPTAAVVAFSTVENLQAKYPGLKKFFDDYPWMIQVFKQISPLGLAVMTALAPIIMRFLSKREGHASNALVNGSMFAKLIYFQTFQIFFVSVIAGSLIDSLAKVWKQPGLLVQMLGTSIPAQSTMFTTYLIVKIGIDLDLELLRVMPLILGLVYNIFAPKLTARERKSPFFGLLPATIAGDLDTGGALPDYYLALLLVITFCAIAPLLNYFAWFYFVVAEMVFRRQALYVYDPSLHSTGVYWPQLHTFLVRALLLAQVTFLGMMSLKSAPGPIVAATILPFTSAIYWVYIEGVFPRSAKYLPVLSCARLDKERADHPFPDMSAAFVQPALRDVDPIKPDYNELATKDEDHPDPVVSPPMKGFHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WQB4</accession>
    <name>A0A6G0WQB4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_012875</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000163">
        <property type="protein sequence ID" value="KAF0729610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WQB4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005873"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000778">
        <property type="entry name" value="Cyt_b245_heavy_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050369">
        <property type="entry name" value="RBOH/FRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972">
        <property type="entry name" value="NADPH OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972:SF153">
        <property type="entry name" value="SUPEROXIDE-GENERATING NADPH OXIDASE HEAVY CHAIN SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00466">
        <property type="entry name" value="GP91PHOX"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01169">
        <property type="entry name" value="NADPH_oxidase_subgroup_(NOX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="312"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="355"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="68"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="11">
        <location>
            <begin position="396"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0729610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="695" mass="78331" checksum="1691B8EE3661DB55" modified="2020-08-12" version="1">MASTRSSKLTDWHNSLQHHGPGASYASSSYYLASSNDDDSSGRMLADHTSSIELKLLDVCVATTRETNADKRLRAVFDLFDVDQTGRLTPAGLQAFLASTMAKHNVTLCGVELHEIVQQAFEAANLRGMNSNQEKALTFADFKLLFQDTLDPRKSVASARGRPSQPAVIRRSKVDKFFSGFVRYQTELQFLALYTLINVAAFWLKWISFPYDVVAGYMAKLAKSCAQLVLLNSMLVLLPMCRSVVGTLRGFRVLWYIFPFDHNIVFHQIAAVVILVAGIVHTAAWIAIVVQAKHATEAEWTASILNKAKTQIVRYGAILDLVATIPIWTGVAMLLCAGFAIPFTFQRVRRWNFNYFWLTHMLFIPFLVFLCIHGAAAWVAPPQAWFWVVGPLALYFIERRFRVTTVFQSQTKLKKVHVMSSAMVLYMKKPRGFRSFTPGMYLFLKVPELSAYEWHPFTISSAPEDSMLSLHVRVAGDWTSALHARLQKPGPLPAIAIDGPVGAPSIEYSNYSTVVLIGGGIGVTPFASILKHLLHVWEEHRCPDCGSVQLPARIKLRKVHFYWVTKEQHCMVWFRDMLNQLSEIDSDGRLSIQTYLTNLSNANASAPLRLIQTFMQNHNERDIFTGLQRSKMHMGRPDWDAEFSRIARAANGEQEEIGVFLCGPPALDKDVNAKCNQYNVKHPEGVHYSYHSEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WQL1</accession>
    <name>A0A6G0WQL1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TFA2 Winged helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_012763</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000162">
        <property type="protein sequence ID" value="KAF0729703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WQL1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006212"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005673">
        <property type="term" value="C:transcription factor TFIIE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001097">
        <property type="term" value="F:TFIIH-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040501">
        <property type="entry name" value="TFA2_Winged_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016656">
        <property type="entry name" value="TFIIE-bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12716:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12716">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE, BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18121">
        <property type="entry name" value="TFA2_Winged_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TFA2 Winged helix" evidence="2">
        <location>
            <begin position="105"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0729703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="396" mass="44160" checksum="56647503EFB693BE" modified="2020-08-12" version="1">MWKNLAYNTKTVVEAKPDGFPMAPMVSEVAPKDVPETVVGRLQKILEFLNSIPGHKAVSVAQIYQKTGIDLSSPGEYEVSERVRNNTKVRTEGELFAYKAKFDIKNRDDLLRQLNRCPEGIPTRDIKDCYATVEDDLRHLTRIGTVICIRNTEDGNDVYFPRGELFLSELSGVAVVEPGSYIAATKEDITTEIRRGDAVKVGDHWFRVSAAPKAGGSSQPPIFMAGMTTSKSVSSVRDLNVDDTKKKPRYMLNFDSGHLPVDTAYPDARGNIMMHQKWDTAPKMGRGPPVKMLKHGCTNDVRQLWRDTLTGWPSDRVALERAMLHCGLMTRDMHEASMNRSKMRKVGKGNKKVPRQRKQRDIKITNTHLVGTALGEALAKGGTDGFTLGAVKFEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WQT8</accession>
    <name>A0A6G0WQT8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_012703</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000161">
        <property type="protein sequence ID" value="KAF0729815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WQT8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018850"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0729815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="103" mass="11843" checksum="26B04DEA8266BBD2" modified="2020-08-12" version="1">MNTFHAAVSALQVALYRQRRQRRTTQIMRLLRRSTTTSTDLNVLSDLSLAALAIKLERLIFLDLPDRVGLLNDEMLELRMRLVIKHILESKDPSKNNNPSEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WQT9</accession>
    <name>A0A6G0WQT9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_012643</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000161">
        <property type="protein sequence ID" value="KAF0729752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WQT9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018666"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="325"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="336"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="363"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0729752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="379" mass="42404" checksum="F9FFA1F40DC58CF4" modified="2020-08-12" version="1">MDAPPATSTIDVSHFSPEQQATLTDLLRLIPENIVRGLFSGVNPQDQIIVIESFRLHGAATAQSAAHAAAKRTQEEAALLYEADLLKATAKIAGLEEPNRNLASHARRSDSPSSGIDDIFIDSRVSRDRPLKLEVSKYGGAPDEHLFRWVSEVKLELGAQLVTNERLRVAFALSNLQGRALDWAYNLHMLYDETFPSFETLVEQLKEQYVHSNVETRFRAKFYQAKQGKGTIQEFVNELRSILGSFENSYRIDEIGRVTVFMYGPNQGPDRDELFRLQPQGFNEAINIALNTEHSRGLARLSGKSSDVSSDMEISRMEAASGDERRCFNCGQSGHFARKCPQPSLERKNPNSFPRRSLGGAYRGRRRGSGHHQGKDKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WRF5</accession>
    <name>A0A6G0WRF5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Chromate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_012501</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000158">
        <property type="protein sequence ID" value="KAF0730012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WRF5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011315"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015109">
        <property type="term" value="F:chromate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014047">
        <property type="entry name" value="Chr_Tranpt_l_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003370">
        <property type="entry name" value="Chromate_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00937">
        <property type="entry name" value="2A51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33567">
        <property type="entry name" value="CHROMATE ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33567:SF3">
        <property type="entry name" value="CHROMATE ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02417">
        <property type="entry name" value="Chromate_transp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004810">
        <property type="entry name" value="ChrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="358"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="393"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0730012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="435" mass="46200" checksum="83A72870B254EED9" modified="2020-08-12" version="1">MTEGGESSLLLNKDVHEPTEPYFKRLVSVAVELFPISLVSFGGPQAHLGLAHERFVERLHWLDDDRFLEVIALGSALPGPTSTQVVSSMGLFRAGPLGMLVAFIVWCLPGFIIMTLAGLGAQHYLGGNLPSWMVGLAPAATSLVIIAAVKLWNKACGGDQVKMAIAAVSVVVVLATQKLGTWIFPALMVAGGITTLLAPVFGYTKSFIKPNQAQNSLIPRELGIPAWIGVLIIVVWLAAFGILSYFDSIHELGRSYLGLFYAFFRMGSIIFGGGQVMVPMLLNDIVSAGWVSKEQFFIGFALIQSLPGPLFNMSTYLGAVVFGVPGAFLAVAGLFGPGVGLFFALLPLWELVRSNTKLQIFMTGVNSAAIGLVVAAIALLWQQAIHNHAQASVCFATGVLVGLFNVPAPVGIVFGGVLGYVLHALNIAQVSYCAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WS83</accession>
    <name>A0A6G0WS83_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_012304</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000155">
        <property type="protein sequence ID" value="KAF0730304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WS83"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006812"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045129">
        <property type="entry name" value="RNF123/RKP/RSPRY1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13363:SF5">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13363">
        <property type="entry name" value="RING FINGER AND SRY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="5">
        <location>
            <begin position="44"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="255"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0730304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="280" mass="30513" checksum="58711A7E4B838D0B" modified="2020-08-12" version="1">MKKWAEEDLRAQRKRDGIGERELPVEVTPSGIPGWHLNTPSSCNSSRKCAIMKPSWYSIQAGTSTVASRAGSWLLPLNGNVHVQQTTKDTNVTLEGDGTFGTATVFGCAFHAGKWYYEVELLTDGVIQLGWADASFEADDEEGDGVGDHVAFWAYDGCREVKWTNGVSATFGSKWVAGDIIGCWVDIDTIGFARNGVDMGVAFTDVRPSEKSESTYGGLFLAFSLEAKERIPINIGDHTFAFKTKNDALPWLSWPSSPARSSPSSHTSSSSNRRVEDSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WSZ3</accession>
    <name>A0A6G0WSZ3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_011972</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000153">
        <property type="protein sequence ID" value="KAF0730550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WSZ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017995"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF91">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PLK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="4"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0730550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="319" mass="35442" checksum="7E9F3391EF5C6224" modified="2020-08-12" version="1">MERYRVQRILATALYGDVLLCHDRRTGARVAIKRMNLAAAQEHKSLVEKRHVPEDVDFEAHVHYAVRAAGGHRNILHMQRDFVEDDCLHFVYDYCAGGDLLDLLRAHDRFTRDIAMNYFRDIVSAVQHLHKLGFAHRDLSLENVLLDASDVCQVIDFGVACSTSTSHSSRVGKAFYMAPEVVAGKTYDGCKADVWSLGILLFEMLTGRPLFDLAATTNPRFELFQAQGLAAIIDTNLVDENCMTLLSDMLSLDPHYRPSLATVLAHPAIVVPSKSGETMLASFMTNVVGAVASSGLAGYFNRMVYSPWTALEPTTVVQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WTG4</accession>
    <name>A0A6G0WTG4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_011902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000151">
        <property type="protein sequence ID" value="KAF0730794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WTG4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021192"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0730794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="118" mass="12967" checksum="4ECE0F7B14CF29B3" modified="2020-08-12" version="1">MESNPSAYGKFDKTDLAGHAHLTKDAIESVCKVAAEYVDEPGYDFKPDTMLPFVTVRPQSEPDKPEPNTKYFWDGVSEAGFWEVQPDVNRIGESGSEDDVASQGKEASGAESEYEENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WUY4</accession>
    <name>A0A6G0WUY4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_011517</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000146">
        <property type="protein sequence ID" value="KAF0731257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WUY4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017102"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0731257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="23934" checksum="405A03EDCF8CF545" modified="2020-08-12" version="1">MLSLGLMDSTTEMNMVRHDTTKKYSEGIRSVRFQAASFDILVAAIWMHTVQMYAKGGSDHLIERRRIDDNTFFVSKAYTIPNTETKMMSRAVIKRQQVGPRAVRMILRSVLADDANPFPPNSIIADQCAWLHVEQDSDGSTVLKCYMRGGFTILKPDEVENLVYLMGFMLVDNPLTKVAPSDWVSVSKKLFEAMFRTVQTHLLPQIPAEATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WV40</accession>
    <name>A0A6G0WV40_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_011404</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000144">
        <property type="protein sequence ID" value="KAF0731341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WV40"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013707"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090734">
        <property type="term" value="C:site of DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052639">
        <property type="entry name" value="TRAIP_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46569:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RFWD3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46569">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRAIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="6"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="72"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0731341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="300" mass="34200" checksum="99C9227A44BF38A3" modified="2020-08-12" version="1">MEEGDCVVCLDPLVQDLRAAPCGHVFHSKCISSAIEARPNCPQCRRKTRPSDLIRLFFRVPAVATTGPSPEKSKNDKKVELLKKALNQHQEELDTARNKLDEWEAYDVKVRSAYTQCESKANELKKDKERLQNEVQLMKNTVELMNKKRKSDEIDEATLTFLRSHDVEALEKELQNPAHIIIALKKANKFRQEQYTKVLKKLQERSKENTIVDVIAPKQREKKLKRALPKTLPPFDLTIRKQTVQPPAPAAPTVVIPKTLSFVERTDLKPIIDLTMSNSTASRPIKPKAFRSTSITSWLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WVQ9</accession>
    <name>A0A6G0WVQ9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_011181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000141">
        <property type="protein sequence ID" value="KAF0731559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WVQ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005513"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0731559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="122" mass="14592" checksum="C757BDFC0DBCA9E1" modified="2020-08-12" version="1">MLLPRKELQKMDLSPPKRAKASPPREPDGGLRSQKQKEFSESENEAIWRRWKAKKDAERRKACQERPMDDIPLPNMDDTKAQFLKWKKRKDEERRRQKLAQREQQAEWGTIARHLELTASRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WWR4</accession>
    <name>A0A6G0WWR4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_010879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000138">
        <property type="protein sequence ID" value="KAF0731926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WWR4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018464"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0731926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="147" mass="16318" checksum="7562F84A4FCCCEB0" modified="2020-08-12" version="1">MANTNLLAFTKPPPNPVDAIADQVKLVTVNSQLAQASAMFSPLLDRFSTTHSTIQQMTRDAHPPPKPPQETVETEAKDTRIEAKEPSTSSMKATSPAREKLQAKHPQKIAKPVPKSAHVPWALLDQLHAEKEKLKTQIAVDRFRKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WWW3</accession>
    <name>A0A6G0WWW3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_010700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sel-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000137">
        <property type="protein sequence ID" value="KAF0732047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WWW3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015192"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050767">
        <property type="entry name" value="Sel1_AlgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102">
        <property type="entry name" value="SEL-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102:SF147">
        <property type="entry name" value="SEL1L ADAPTOR SUBUNIT OF ERAD E3 UBIQUITIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0732047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="468" mass="52462" checksum="99AE0AAD9D232975" modified="2020-08-12" version="1">MMRLITVVKATLRRPVAFQRVVSSRNRCQAMTLHVPRALQVRFSHQSTSSEDNKFWQEIKDLHVRAHAHDAAAQYQLGLMYLEDENEQSDDDDWTLDAEAQRQRANATSSGPTDIKSIRKQARKMYKEYVLSRLQTPGPERNLITRTTKATLDAVYCSVVQPLLDGSRKLAPFNEQFVEPENNMELMEEGNAKAVEWLRHAADNGYRDAYVRLGNLCMAHDPPLVYAAIAWYSAIAVKCDAPHPDALYNLGMIYYEDHPNLEPPLKQDMPLAMSYFMKAAEIGDPSAQYFVGHILHVGNDVVPANPLSGRILLEQAASQGHGGALYYLALLYRTGDEDMGISPDAAKCIKLLEQAIAADDDEALVCLGDMYREGWPPHVNVDVSRAHELYERAAKLGNAEALCTLGALAYANELYEVAFQYYQAAADRHSMAAWKNLADMYYAGVGVPQNKKTAESILAMLKREMTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WYN3</accession>
    <name>A0A6G0WYN3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CBM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_010347</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000130">
        <property type="protein sequence ID" value="KAF0732639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WYN3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015133"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026081509" description="CBM1 domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="4">
        <location>
            <begin position="232"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="189"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="191"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="208"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0732639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="270" mass="28600" checksum="7407791A212ED3B2" modified="2020-08-12" version="1">MFTSITATLVAFAATAYGHGQLVDPLATFKPNVDVTAFCDTMNGPKVLPGDQYNNSPQYNSAAFTAHFKNSSYVDLKSFISANGGRVPLARVLPQAPHAKPFPSDNIVKWHHGAGEGFTPSHTGPCELWCDNTRVYQNDDCAANVPTGGMTVTSTACANAKQLTIYWLALHNPDWQIYINCVPLTSGGGAPTPSTSSSPVTQPPATSRPSSSSQPPATPRPSSQTPVTSRPTPSTMYGQCGGQGYTGPTSCQQGLVCKQYSPYYSQCVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WYT7</accession>
    <name>A0A6G0WYT7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_010381</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000130">
        <property type="protein sequence ID" value="KAF0732674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WYT7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005704"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13999">
        <property type="entry name" value="STKc_MAP3K-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF214">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="126"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0732674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="401" mass="45870" checksum="3E721A3146495E5F" modified="2020-08-12" version="1">MAQATTSGQRLRQLGDSDALNIGLGVAIGVILLLVVAFWLYQRRKNKSRLEERHARRANDRHFAEEDDQRTINFNGRPSKKCPQADNYHLEDDEYRHAKNKKAAAKQALFQMDQEMLDAKIDYNAIQYTRKLTKGAFGEVWLGQYRGKYVAIKQILEERKNDTKEIECFVAEIKLMLNLKHPNILDFLGFSWNPKDHNLCFLTMYMKNGDLFYYLQKRKSNLSWKREKIQLALDVAQGLVYLHSLTPKIIHRDLKSKNVLLDENFTAKINDFGISRVRQFEETMTAGVGTALWAAPEVFMAKKYNDRADVYSLGVVLSELDTCAIPFADQAVGKNGKLDGMAVIKLVTQKRAKPTFSPQCPKPVLELAMMCLDYEPDNRPSAAEVVRLIQESIRPALEAAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X098</accession>
    <name>A0A6G0X098_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_009841</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000124">
        <property type="protein sequence ID" value="KAF0733279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X098"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001772"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002761"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005381"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007669"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052187">
        <property type="entry name" value="MFSD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23512">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23512:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0458">Lysosome</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="567"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="866"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="966"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1117"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="568"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="590"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="615"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="628"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="686"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="702"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="715"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="780"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="800"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="813"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="839"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="880"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="899"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="966"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1009"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1127"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1162"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1186"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1210"/>
            <end position="1241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0733279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1250" mass="137325" checksum="64D9CEE2D55A4355" modified="2020-08-12" version="1">MMDTATTKRSVLVFSSLLILGSSYCNEIPMSALKSPLQEQFHRLPTSYSLYSVLSMILPLLGGVVIDRVSVPIVAVVLTGLVLTGQVISAHSSTSMDFHLILLGRVLVGLSGEVLKVTQAKFVVSVFDPSELAFAFGVTSSISTLASILNDKWCPWIGDDYDEISALWVGVGVSALSFAASLVLCRFKMPSTSATDESMSFPAVRRVSWLFWLIVVKFFAVGCMSPFTNAASGIFLERDFFQKPPLPCQRCGFGEFSTYCNRISPHCPLVPPYAWPLPLLSKNCSIVTADDQYLCSVASPFLDERDIKCSEKQWRYGPFTLQYCTAKIQAQQAAADVLSIRRTLQTLLGPLAGAFVDWFGLRPHVLFVAESAAAVAHVLIGFSRVSALIPVLLLGASSSFTGSTTSSAIPLLVPADAIGAAFGLVPVAQNLASAIASVVISESYSNAESQYLPQVQTLFIAFGVVNALLALLLIVMDAKGGYRLCHFSQKFSDDDKLPLRLKSSLLEVYEAHEPSRRERRQCQEFIYVGGGSWHAEDVSAVHIGHMHFQFEIKLSTMLSFFGLTSASPAKPAAAPQQTTQKQEQKNTQPAKPNTAQKAKNTQEVKPVTPQQAAKQEQKPAKTQDNKQKQQQQPKQQQKNATPQQQQQPKQQQQKNAPPKQSETPKENQKSKAAPVQQPTKMKPMTPAQQLEMQQILNILIDDAGKDWKPRDKTNKQPQQKPAPKQAQKTPKAQAPKPQEATPKASQKAAKSSSPVQQAPAPKTAPALTRKVSMTPAQLQEQKEILHILIDEDWTPPAKKPQTNQKPTTRPGSAKTKQNTPAKTTTTQAPSATQKKTQTHSKLSLSPAQQLEMQQILNILIDDAGKDWKPRNKTVKPHAKQPNQKTSTRPTSAKPKAPIQKTTSQTPPATKQATVKSHKATTQQKPTSDQFTKPEALSPVLQLEAKQFFNILIDDAGKDWRPRNVTTWPWSPKNGSSPKTTHKAKVSSKPVAKKNTVSKVKAPTKSSVVKPDKPLHRRRSLTDAQKREKRAIMEILLEPYEYVPAPVRPRSSTVQLHAELDHKVGNVVVVSNQPVDASEDLSGFETVKSRHTTFQEKKEFRQEIGDMMSILIDWTEPLPKKQAKQTPKKATPQKTLTKTQTPTKSAAQTPTKPQTPTKAQVASKPQTPSKPQDTPKTQNKTTKEAAKPQTPKKAQDTPKPQTPTKQKQPSAKEQPSKAQAPKTHSTTQQQKGPPATTHIQANKNRRAKLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X0G0</accession>
    <name>A0A6G0X0G0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Minichromosome maintenance 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_009585</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000122">
        <property type="protein sequence ID" value="KAF0733335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X0G0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009133"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22247">
        <property type="entry name" value="MCM8_WHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056875">
        <property type="entry name" value="MCM8/REC_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF47">
        <property type="entry name" value="DNA HELICASE MCM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25051">
        <property type="entry name" value="WHD_MCM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="11">
        <location>
            <begin position="331"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="539"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0733335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="759" mass="85150" checksum="99426FC68466438E" modified="2020-08-12" version="1">METLTREEWSVALAPLWKEYFMTEEEPDIKESDMLPPLLGFLDMLRECRKPEGFLEHYNLSDVTVVTIHCKQLFALFGDDAYECFVVGYEHYLRSLGLALCMLRHEEEVAASEYELHPRPRLEMNAVKINVRVVGLEPETSIGDLRAHVVDQFVCVTGTVTRVNAIKPLVVHCEFLCERCEGVTYRYFPDGKYDPPPSCNTCRSKAALLPNRSAAKTVDFQKIKIQEVDNGDAAAGRIPRMVEVELMEDLVDSCVPGNIVTICGAVKAVNSEVHNGRYGKQAQANSLYVLYIVANSVVNLNQTETTSKEDSVEFSTQDLDAIFKIAHMDRVFDRLIHSFCPGIYRNELVKAGLLLALFGGTNKREENAVFARSDSHVLLVGDPGLGKSQMLRAVSMITPRGIYVGGNTATTTGLTVTMVKDSSGDYALEAGALVLADQGVCCIDEFDKMACDYQALLEAMEQQSISIAKAGIVCNLNARTSVIAAANPSGGHYNRGRSVSENLKMKAALLSRFDLIFVLLDRPDASRDQMLSEHVMHNHLASRHKRQRRDSQIVPTHAQDEGAPATMKQRLIANWADFHDEPISLYHIRRYIAYARKYIHPQLSQEAKQYLQDKYLQMRSDAETSSDGIPITMRQLESLIRLAQARAKIELQEIVTVEHAHDVVEIMQECLLDTYTTEEGNLDFGRSGGMSLAKKVKAYVARLKKSAVQRNNQMFSMEELLQVANSIALQVDDFRDFIEILRNECFVLKQGPNIYKVQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X0N3</accession>
    <name>A0A6G0X0N3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_009611</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000122">
        <property type="protein sequence ID" value="KAF0733361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X0N3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009107"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051150">
        <property type="entry name" value="SWT21/TCAB1_mRNA_Telomere"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13211">
        <property type="entry name" value="TELOMERASE CAJAL BODY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13211:SF0">
        <property type="entry name" value="TELOMERASE CAJAL BODY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0733361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="382" mass="42898" checksum="3D605C1E65B266BB" modified="2020-08-12" version="1">MSTEETLEEEAQAVPEVKWYEHVQGATATLEMTISKPFGAHFTKGVKVSPDGLCVLSNSDDNVMRLFEVEPSVQEATLEMHEGGTVYDFQWYPYMNSDDPATCVFATTSHAHPIHLWDAYTGELRASYRAYDHLDELTTAYSVAFNATGDKLFCGFDRTIRFFDVSQPSRDFSTRALSKTKKSRHGQRGIISSINFNPDHSKMYAAGSYGGSTCIYDENTGEMFMGLEGHNGQGITQVQFTPDGRYLLTGARKNNVINVWDIRNTMQILHTFEREAPTNQRIAFDIHMGRRYFITGSADCRVRMYDLFSGELVSEIRALPDSVNGVSFFPYPDAARLALCTGQRAYDLPQDMADDDEMAVGSSAGRNCIQVYEFMQNPHVNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X0N4</accession>
    <name>A0A6G0X0N4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein O-GlcNAc transferase</fullName>
            <ecNumber evidence="3">2.4.1.255</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_009695</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.255" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000122">
        <property type="protein sequence ID" value="KAF0733449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X0N4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012391"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012392"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097363">
        <property type="term" value="F:protein O-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029489">
        <property type="entry name" value="OGT/SEC/SPY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44998">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44998:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13844">
        <property type="entry name" value="Glyco_transf_41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 8" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="54"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="159"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="227"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="O-GlcNAc transferase C-terminal" evidence="9">
        <location>
            <begin position="592"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0733449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="794" mass="88899" checksum="3E7F3C31C1A5E30C" modified="2020-08-12" version="1">MRWQRQISAMTSWLAMAFAGDYIARGISYQLEQRDLVQAKAMYVAALHENASNIEAWHLLGVCAYSEGDFHQAQTYFERGIEVALDDAASATTHCNLAETLRKLHQPNLGLPHALVCHNKTRASEFSLRVLSWLYIDLGMQDNAADILQQLVAINQDDIDAWHSLGSVYAYESKLPQAIHAFSRVLEIDPHDTRGFAGLGQALHLSGDLAGAMNAYNTALAINATDVPTLQGLAVLYQQLGRLPEAIAIYERILREQPSNVPVLNNLGAALKYVNRRVESVKLLEASIQLDPSNTQGYVNLASYYEEEGDLGKARAMLTKAYDISKADILRIHLAIMLPQVYTSHEHLLATRVALEAGIDDLLNDSLSIDDPVDFEVRPPFYLVYQGMNDVAIQTKLARLYMQSCPLLTFVAPHTMHGVGSLRHFDESPRRLRLGFMSKFFVHNHAHGLLLRGILAHLNRDVFEIVLLAVPDPQQSVDPLMAAAADQVKVLSMHLGHVQQDIAALELDVLVFADIMSEPINYFTAFSRLAHVQAAFWGNPTTSGIPNIDYFISADNMESSPDPAVESHYLEQVVLLSGLGIWYDEIEVPATLGNHSDYDLDPSWTVYMCPQSVYKLLPSFDAVLIEILRRDPAGHLVLLQARRLSWTQQFQARLAATMPREMHDRVHFVPRVAGNAPFLKLLSVADVVLHPFPFGGSKTSADALRLGIPLVAMKTPFLRSRMAYSFFVHMDLLDCITTSEKEYIDKAVRLGTDRLYHDEIAQRIKAKQSMLWESHQVVQEWERFLYNAVRSLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X0R2</accession>
    <name>A0A6G0X0R2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_009706</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000122">
        <property type="protein sequence ID" value="KAF0733462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X0R2"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0733462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="163" mass="18419" checksum="2AE44754F377A2AA" modified="2020-08-12" version="1">MAHRRAEGTFERLLVGLSGQALFLREATQRGTKEEERAVPRRVERHAVQNAFHRFQAVDARFRPSVAPLQQRVENVWRRADAVADVEIACAQHGAQVSMVVVLDILVVVRRVGFAARPPFMLRLKHLDEAIPLAAVAFAQTLPSLDHRLQRRQRRRLGAPLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X2Y6</accession>
    <name>A0A6G0X2Y6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_009126</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000117">
        <property type="protein sequence ID" value="KAF0734265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X2Y6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014464"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="entry name" value="Sodium:dicarboxylate symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42865">
        <property type="entry name" value="PROTON/GLUTAMATE-ASPARTATE SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42865:SF7">
        <property type="entry name" value="PROTON_GLUTAMATE-ASPARTATE SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00173">
        <property type="entry name" value="EDTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="Proton glutamate symport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0769">Symport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0734265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="444" mass="48164" checksum="7ACCF52C6F0597FC" modified="2020-08-12" version="1">MVAFHAQEDITPKEPKTLTRRILTSLTFWIIVGTALGILLGSEAPDFSKKAAPTANLFLRPVQFIVFPLVFSTLIVGIAGNNDLKSLGRVVLKSFIYFEIVTTIALILGLLSVNWVKPGGSGFATVKNPNVSTADKFTYALWINHLAPKTWGEMMGGSGSSELLQVLVAAVLFGTSTAMANDRAKKQIIDVAEAVMWVMFKFVDIVIWTAPLGVCFSVANAIASNGGLHVLSSLGKLIATLYGTLLVFIIVVFGPVFLYLRMNPLEFIRGMREPLIIAYTTATSEAALPKVFEALDAFGVSKHITAFVVPFGYSFNLDGSTLYLTLGSMFCAQAAGIHKSVGEQITMVLMLIVSSKGVAGVRSASIIVIASTLDQFDIPAWTVGLLLGADWFMDMARTFTNVFGNCLAAVVMAKMEGEFRKEGWNDPHEIADLEEELIPDKHYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X3H5</accession>
    <name>A0A6G0X3H5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_008825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000112">
        <property type="protein sequence ID" value="KAF0734476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X3H5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000525"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0734476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="251" mass="27551" checksum="D10C9F4139E4F365" modified="2020-08-12" version="1">MVGVLPDKDDADRATGTSGRRQSSIPPMRLHMMRLNVRPPLTPTVLCLVASLFTPSTALSNSTKPTPRPTTTAPVVVSTNGALSDTTALIIGLCTGILLIFTMVMVLVCYRRRLQRKAFLARLSQHLMSPSAMATVRQPSLAREGQGHLVRFNHSTRSSRIDFAPSSCSSDTDTLENYTTSSSWQVQQPDQSLPVRTIPASQVRPLRDSSFQRSFDLELITSYVEHPAVRSSTDTWFATQRHGTPPLSSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X3T0</accession>
    <name>A0A6G0X3T0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial</fullName>
            <shortName evidence="5">Glu-AdT subunit A</shortName>
            <ecNumber evidence="5">6.3.5.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_008756</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-glutamyl-tRNA(Gln) + L-glutamine + ATP + H2O = L-glutaminyl-tRNA(Gln) + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A, B and C subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the amidase family. GatA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.7" evidence="5"/>
    <dbReference type="EMBL" id="VJMJ01000111">
        <property type="protein sequence ID" value="KAF0734509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X3T0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018609"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00120">
        <property type="entry name" value="GatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004412">
        <property type="entry name" value="GatA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00132">
        <property type="entry name" value="gatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF7">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="6">
        <location>
            <begin position="40"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0734509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="529" mass="56507" checksum="A1C3D6998B978188" modified="2020-08-12" version="1">MMRFQIARRYAATRFSSSWAGRSLTEASDALANGSVTSFELTRGCIDQIQATDRFNMFVAKTFDSALDQAAQSDLRRKNGQALGPLDGIPVGVKDIFCMKNGQPTTASSKILEGFVAPYESTATQRLLDAGAIPLGKLNMDEFAMGSATKYSTFGATINPWSSDLDKNALAAGGSSGASAAAIAAGCCFAALGSDTGGSVRQPAAYCGVTGLKPNYGRISRHGMIAFASSLDTPGILTKTVRDASIVLRAIAGPDTNDSTSLPDVIEPSWCALPSSKQEDLSRLTVGIPNEYYVKELPDQILKVWDQGIEWLRQSGARVVEASLPTTKYALPTYYILACAEASSNLSRYDGVRYGFRAAPSDDEEVDNSVNQATALHDLYCRTRSQGFGEEVQRRILSGTFVLSAGAFSDYYERAVLVRQQIRDDFAATLGSGIDVLLTPTTPSGPFGLHTKADPIDMFMNDIMTIPASLAGLPSISVPAATTTDGFPLGLQLIAAPKQEDTLLRVALAMESHANFDQHIPPRVLTAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X4P6</accession>
    <name>A0A6G0X4P6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Condensation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_008610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000106">
        <property type="protein sequence ID" value="KAF0734759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X4P6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001469"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001470"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0734759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="37024" checksum="8F511786CD4DE3FB" modified="2020-08-12" version="1">MVSSSKMSVAVRLLEPEGYIVHAPPTQTITIYSTDSPGAIPRAKAYVQARLNAIVQANPWLTGRVVTDFIGTNLSLQYDPTANTLPLEESSMPKLSTAMDYQELTNLFKPLEVRQGTDLINKDEPPFRVHWITITPTRCALFMTISHGISDGYTYYRYRLYGMLSATTPIQTLDPNRFYDFEQVSNVNSAWGNDSAALMSRFPLICNILGTLLFSPKPNYALRTISKDWIAREKAKAVAHLPHVAFVSTNDVLTSWFFRECNSVVGFMTINYRGRMKGLASHLAGNYTSWLGYQPEDYASPALMRESLTSNVLRRVALATFRGCSRALHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X5X3</accession>
    <name>A0A6G0X5X3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PARP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_008212</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000100">
        <property type="protein sequence ID" value="KAF0735297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X5X3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002480"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.10">
        <property type="entry name" value="Zinc finger, PARP-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001510">
        <property type="entry name" value="Znf_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036957">
        <property type="entry name" value="Znf_PARP_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM01336">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50064">
        <property type="entry name" value="ZF_PARP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PARP-type" evidence="6">
        <location>
            <begin position="17"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0735297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="90" mass="9967" checksum="4BA4210F7E8C4025" modified="2020-08-12" version="1">MTVNPWTKCDLPILGIAKNDKSMCQACQDSIATGSIRVGIIFHHVNGTIGVDWHHLTCCETPAALPQVEGYELLGEQEKEVLHHWIQSCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X6P6</accession>
    <name>A0A6G0X6P6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">IPO4/5-like TPR repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_008034</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000095">
        <property type="protein sequence ID" value="KAF0735555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X6P6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013281"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013282"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041653">
        <property type="entry name" value="Importin_rep_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057672">
        <property type="entry name" value="TPR_IPO4/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18808">
        <property type="entry name" value="Importin_rep_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25780">
        <property type="entry name" value="TPR_IPO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="IPO4/5-like TPR repeats" evidence="9">
        <location>
            <begin position="95"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="8">
        <location>
            <begin position="119"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0735555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1111" mass="122641" checksum="9BECDFC0141E6400" modified="2020-08-12" version="1">MLHTTLIRSLLSNENDIRRQAEATYTQLKAQQPQELAVALLTLACIQSNPDDADTRLFAPVLLRRLLETDGLANDAAYRSNMKQQLLSTLVLETEPQIRRKVTHVIAQVARQDANWPDLLPSIINLTQSSDIALQVTALDVLGTLAEYTGGQFTVHHEQLGSLFSSFVASTAAPMELRVAAWKALSAFVVHLESNESLQPYTQLLPPFLQILEHLLQLRDEASARSLLTSFLTIAEVHPNLLLLHLDMFGSAMLSIAQSSVLGNDTRILALECLLSICEHASQLVRSSKVLLEAVVSCVLVLLAEIPDDDNWVNQFDDQKDDTGVRMTDAGAAAIDRVAHSIGGKVLLPLVLPWLTQYMDEKASWQQRHAALYAIGLMAEGAKEYLYNELDNWFPRIVASLHDPVFPRVRHAALFCIGHLAKDYGIVERGKNFQAKYHNDVLPPLIPMLFEHETVMRNRGLAASVVCNFCHPEHCRTQFVLPLLEPLLSALFQALQTSPRQVQEQAITAVACVAKVVGDAFVLYYNVFMPVAKQVLTQAHGKPYALLRGKAMECVALIGQAVGKQAFLEDAKVVMDILLRHETDDSGIEVQYLTQACVRIGSVLQEDFVAYLPLIVPKLLQQAATQPDIVLLDWNEQTTVHDDDDEDEHGNNGIQEIVVEIQGQGKKKLQIQTSSLQEKELGLNMLYQLAMDLQGAFVPYIEPVMQVLLPLLRFEYMDTVRMISGLTMAKLLHAAVAGSEITSQGPQQVLEACFEPLLQALLEESDMECIVGLSEAIACVLEECKEGAAKGFKLGIPLAHLPTVFDKLLAVAHASVLRQVQAFNSFNEEDEDEEDHEPESGEDEEAILQNVVDAIGWCIKQYQVEIVPTFVEAILPRISPYLEPSFPAAIRAHFICTVDDMLEYGGAETLLTALLPHLSNSLEDSHPSVIRAAAYGAGVCAQFGGPGFESHCVATLQRVWTCIQALEHDQVETEQAAARDNCVSAVGKFCMYRAHLVDVSTLLGLWLNCLPLQSDAIEARAVHQDFVSMLLSTNMDLLGENYARLPVVLKKLADIAALDEEVDEPIVETDTKAQFQTVLLQIQATIPSQIVQAAWTSLAESDQEILSALMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X7M0</accession>
    <name>A0A6G0X7M0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_007886</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000093">
        <property type="protein sequence ID" value="KAF0735884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X7M0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003773"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="335"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="363"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="465"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="568"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0735884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="670" mass="73495" checksum="F83CB764FCFF08B3" modified="2020-08-12" version="1">MRRLPSKRKFAKKLKPKLSVAYISKWCRVISNLMAGAGIFATGVIVLLLLTQGMFYSTNFYTFPQDTWVPRYQSCRLSVSGFSSCHPADIAVTGSAPWTSIGLQLASELDLHNSTVFATTCALNLPVSATQAIGKIIFLVGETSFPSCNPVGPQVILGMAVVDTVGTADFPDGAFLMSVFSDAKPIQPATVVDTQGNTIPVTTSATKTIVAVNGTRVPTTWGQRNFVTSLNCLNRFFLMQVWAINHFPDLSASLKTMEGYSVGKTTGYITTFGLDNSHKVDNYMLLFLFQIVICSVTLVLLGNDGLITLEGLSGLLKNKPVLTYDILASLERRKILLFALVGVFLFSPLYADVIRYTYTINGYHYWSLSLVMVGLIMALSWMAILTCIVQWLPVPAAWRNRPVCYSAPFFVYCNCIGFVVVEAAQRRGPSAAATFWGDAPSTLCLNMDGMAVVSGAFSMDGATPIIYTLMPDIAVVLMVSWLVSIAAHKVLTGSVVLEMTWTAQNAFVNQVALPQWVTSLDLDKKNTIAIGTKLYCRPSLMVLLGYCTVYDDNKYRLPKDEHLNFSSHMSSHTEATEAGTSSVGTSTMRGKVMVQPQPGRPSKAPSSHEDVHYMVISIYGLLAATFPWIRKVYQPQIFGEIHQNKFTPSKSITRIEKAHAYVYSRGDCCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X7V7</accession>
    <name>A0A6G0X7V7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_007686</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000091">
        <property type="protein sequence ID" value="KAF0735936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X7V7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002831"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0735936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="412" mass="47270" checksum="ECB265B9F7E7722B" modified="2020-08-12" version="1">MDGTWDVLEDLRFLLLIATDDQLQDGLAHVCSMLDDDSDDSRDASIEGRDLETIVVANTESDIKQTKAKPSRKRKKPRTTFEVRQREELQRLRVEVDTLKDNLRSLKTASPSCEEKMPFWKRMAHDEKLEKDTALHENEALRGAVDQQATFIDQMKKVLLKKPRLIHHHDVHSAEWQSYRLAATKSLRQAAIHAIADRQLRRLNHVCLRAGLFDRTDDFTKAELRLEENGSVFQAKYLPLGVTEALELIDESTVYSRIADIRDPAKTWHSNLIRKVYREPDRTIFISRTVLDDALVPQMSTDGVENKSVWNQVAPLDDSSCRITLLIQIGLNEILNDPTAVQCAVDMANRINRILPNSLTVKEGNYPIMPGMFDIDFTQVEHPSIRFFLENAMRIRDSINLALHNVIPRKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X7Y6</accession>
    <name>A0A6G0X7Y6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_007617</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000090">
        <property type="protein sequence ID" value="KAF0736029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X7Y6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020109"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111469">
        <property type="entry name" value="Geminin coiled-coil domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0736029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="412" mass="47871" checksum="D8643261305946D2" modified="2020-08-12" version="1">MEGVDDLGDILPSVGSDLLITSVESQGKEDAFMWATVCSILDTPRTNEQSTELPKAKRLRVYTNKSEVQQLEAEICELQAQLQEAKRAVESRTHSSRWERIAEQQRMEKFKAMQENRQLRTAVQERGEYIERFQKLIVKTPRWTALPGVAFDDKSHVLPEDPRLRIENIHRLADEHYSRYQNEFVKAGALDLGEDMCKGEPIHLSDQQLGFRSVNHVNLPAPFRLMAWASWKGMSNRTPAAQSLQEHDIEILELIDDHTLYHRYQNKRGGVVYHSNMIRKYYEDEQCAVIVWVPVLQDGLVPLQPIDMIDELCCWWLFTAHPDDSEISRMTVVSHWNISRLLQHQEVNVPSDQVLDALKKMFVSRKSLREVQPPSFLQPFIERSRRLRNPMRQGIEEAIRDYRHSMKSGVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X7Y7</accession>
    <name>A0A6G0X7Y7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_007672</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000090">
        <property type="protein sequence ID" value="KAF0736086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X7Y7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005961"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0736086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="20487" checksum="095B88CC9E4DE76B" modified="2020-08-12" version="1">MPRQTLEIVDAYTVYQTFKNTGNNVVVHANVIYKYYVEMDREVVVWRSVLEDELMPHMKEGSVQNKWGWLVVAPTKDATSCRLTYLHQVSPLNQNKQLGYAGLVKVKKVLKEKYGFIQPPEIPGTFPGGAVNEEVVLPIQFASRAFVERDKALEWTLKRVIDNIVFDFQQINQSPTRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X834</accession>
    <name>A0A6G0X834_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_007239</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X834"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017255"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052980">
        <property type="entry name" value="Crinkler_effector"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33129:SF1">
        <property type="entry name" value="ATP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33129">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0736216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="288" mass="32798" checksum="93FEF76007F84C6E" modified="2020-08-12" version="1">MIQAMIACMARRIAVVGNAGIGKEYIELVILLWRARRELRPDYTLDDFFNGIDVIARVERDNRTDLFFKSDQLHYGIEHTDWPNLSRLDSKTTLLLYEPCESENEIHECGITDGRVWATASPMPTRYKEFSKTDCAVKYMECATDDELVFMAAVQEQGLDVNSPLKGLYKPASVRERIQTLGPFQRVVLPTSTSALDVEKQNKNAALAIMTSEKLLKAWNISEESSNDGLSISRHLLRMSPNMDNILESYTLKPASNEVKEKLGDMLFKTDVMAMRAQLARYNDNESW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X8B3</accession>
    <name>A0A6G0X8B3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_007317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X8B3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005674"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050167">
        <property type="entry name" value="Ser_Thr_protein_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23257">
        <property type="entry name" value="SERINE-THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23257:SF958">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE WNK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="299"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0736296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="545" mass="62052" checksum="0D560B51EA355E7B" modified="2020-08-12" version="1">MSVHFEPIVEVLLEAGADIHLQNKNGKTAHDLGSADVKHLIAQHQQNEMPKSIRSAVEIILQAIDMIDGETSDLVVTAYKILSHSVNLHIQRERVLATSLMIERIVRHVMSKGPPSEAPDLVPTLKDIETYWETTLMSMQTWKIQLNDPYCLAKIQIIGDEIFRLQDRLLQVTENLHVHLKIQVVGTIDDLRYDVGNLMNKMATIAKCLESIAGIADLQQQQDSLLKLAIQFQRSPEREVALGNIPRINDFQELVEFCKDQIGVTAQVLSETREMPKSFSLEVIQTWMLSSDDVSFEPENERSILGQGGFGSVNVTDSADLEKLIAREVKAWKDISNERYMLTLIGVCTKIPKPIVVCELCQKNIRRYVRDWPETLIPLVYQFARGLLTLHNANIIHRDLKGDNVLITFQNTVAIADFGLSRTATSFENTMTDPKVAGTLNWMSPEQYFTPRSVTTKSDVWSFGMTLWEVVCCDTPYKGCSIYEFEEIFQTDDDRPEKPEEFDPILEPMWTLITMCWEREPSARSSASDIVNYLEEHYSSELPEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XA86</accession>
    <name>A0A6G0XA86_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_006778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000085">
        <property type="protein sequence ID" value="KAF0736966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XA86"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008059"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0736966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="428" mass="48669" checksum="BB8A472843E80706" modified="2020-08-12" version="1">MENDLIDALGTIPWDDALAPQFDVDEFLDEESLSTAPAALADESTSKSESTTSTSTSPRPDKLTSSSTSGPKSINQSRKRMREEIAYLRSKVDELEAHLKVLQQIKTLEVTFVDETPWQKTANDMRIAKKAALHVNSKLRHELQEQIEFGKALQTLMAKRPRLTMLPSLDGDQWQILKLVKNPQLRQQAIHEICERQYQLTQVALVEGGIFDRVGEFEAYTPRLAKTNADLVVQAAYCTTKQFDFQVMSEMAWKVFEGCLGAKNSNLTSHTLKTLDQNAVYVRKEKHWNDLLNQANCLYKRYREPHRDVIVCRTILEDEEIPFHPGALVMNKSAWLVLEKLDGGKACRLKYFQKSTLPMVQSNFGTKNLVDRAETSRYYRVGNVTNAVLLSLQNLIRDVSVTLRLLVDNYTGNIDDTFELVNRLLVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XAD9</accession>
    <name>A0A6G0XAD9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_006896</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000085">
        <property type="protein sequence ID" value="KAF0737092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XAD9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021127"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053201">
        <property type="entry name" value="Flavunoidine_N-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12350">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12350:SF19">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="4">
        <location>
            <begin position="4"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="5">
        <location>
            <begin position="129"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="5">
        <location>
            <begin position="306"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0737092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="41446" checksum="9B54FE9BCB9DBF12" modified="2020-08-12" version="1">MLPPQVKLDSFDLYGFKCHGLFAQEDLDANTVVWIWDRATEPLVTFTRKEIMDHPEREKLVNFSYMVNDDCFASTTEPEADPCWYFNHSCDPNCWFEGDDKIVTRRPVLKGEQLCYDYACTETESSLHYGMECRCGADTCRGQLKFTDWRSRGFIKKNLGHVTDYIMRKHAENGWYDTRMELRYKSKTSMGLFCREESDCKILKGDIVLMFSGKIIHKDHLLERNAMTPRDFEMSLQVHRDLWQIPAWKETGDKCETSDYINHSCDPSCGMLDSVTVVAIRDLYPGEEITIDYCMVNDGSNDQPSDNFTCMCGSVNCRTTITTLDWQIPELQTRLGQYFAPFVKRLIDDTPFSDVKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XBE7</accession>
    <name>A0A6G0XBE7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal peptidase complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_006458</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Dispensable for SPC enzymatic activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPCS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XBE7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015814"/>
    <dbReference type="OrthoDB" id="263893at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009542">
        <property type="entry name" value="Spc1/SPCS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13202">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 12 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13202:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06645">
        <property type="entry name" value="SPC12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0737285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="77" mass="9163" checksum="7A0203C396EE33B8" modified="2020-08-12" version="1">MVDYQGQKLADQLMNYIFALVCTPAWFYGWMQDDFTYPLYAWGIACVLVCLVVLPDWPFYNRNPVQWRSSLKKSKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XBI6</accession>
    <name>A0A6G0XBI6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Importin subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_006685</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the importin alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XBI6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015553"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000021">
        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.690">
        <property type="entry name" value="Importin-alpha, importin-beta-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032413">
        <property type="entry name" value="Arm_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002652">
        <property type="entry name" value="Importin-a_IBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036975">
        <property type="entry name" value="Importin-a_IBB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024931">
        <property type="entry name" value="Importin_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16186">
        <property type="entry name" value="Arm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01749">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005673">
        <property type="entry name" value="Importin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51214">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="IBB" evidence="8">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="113"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="156"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="240"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0737529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="530" mass="58941" checksum="A0F4CC2C1FC35221" modified="2020-08-12" version="1">MASQERQRNFKKGIDVDEIRRRREDTTVQIRKSKRDEQLAQKRRMAGATQMDVATPIDSADAQVQQQINNELPQLAMDLQNPEPLKQLNAVTRFRKMLSIEKNPPIEQVIQLGVVPVFVEFLKREDNPRLQFEAAWALTNIASGTSEHTRVVIQHNAVPIFCQLLLSRDDDVREQAVWALGNIAGDSPECRDVVLSAGALQPLMQQLSENSKPTMLRNATWTLSNFCRGKPAPHFDHVRPALSTLAQLIYTQDEEVLTDACWALSYLSDGNNEKIQAIIESGVCKRIIELLMHPSPSVQTPALRTVGNIVTGDDIQTQVMINLNVLPCLSALLHSPKKGIRKEACWTVSNITAGNEQQIQTIFDADIFPILIDYVQTADFDIKKEAAWAISNATSGSPEQIRYLVHLGCIPSLCALLDMHDPKLISVALEGLDNILKTGEKEGEANGSHVNPYVSVVEDCEGVGRIENLQYHEIDDIYNKSVVLIERFFHGEDIDDGGATSAQVRDGQFQFGLGGDAGNVNVFTFGEQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XCG2</accession>
    <name>A0A6G0XCG2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helicase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_006264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000081">
        <property type="protein sequence ID" value="KAF0737770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XCG2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002368"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005114">
        <property type="entry name" value="Helicase_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37066">
        <property type="entry name" value="HELICASE-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37066:SF1">
        <property type="entry name" value="LNS2_PITP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03457">
        <property type="entry name" value="HA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase-associated" evidence="1">
        <location>
            <begin position="103"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="1">
        <location>
            <begin position="184"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="1">
        <location>
            <begin position="261"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0737770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="369" mass="42354" checksum="FEB753A6F0760467" modified="2020-08-12" version="1">MPQHVRRDVRLSLAFLLHDNHKPKVDSAISRHNQELLVRVVQLSATPCLPTLHSVPSGHPFPLDIQGTTINVGVYREAHRRHKLHHDIVRQLDALGFVWDLKQHKWQVHVAALRVYKTIYGDVLVPQAFVLSSSMDWPTETWKLPLGRLVGTWRQTEATMSADKRAELDRVGFVWSLAKTKLFSWADKLLALETFRRLHGHVQVPPGFVVPESTEWPKTTWALRLSQTVHNLRFSSESLSSEKRAALDALDFPWASQRLKSSWSDKLTALETFKQIHGHLVVPRTFHVPSNDPEWPGNTWEIHLGVLVNNLRTREQPDDRRLQLDALGFVWGTMAFQWQVNLLALRTYKAKFGHVRVPQSFQVPTEGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XDL0</accession>
    <name>A0A6G0XDL0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">Ae201684_006121</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0738138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XDL0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008413"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0229">DNA integration</keyword>
    <keyword evidence="15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="13" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="14" id="KW-0917">Virion maturation</keyword>
    <keyword evidence="16" id="KW-0862">Zinc</keyword>
    <keyword evidence="16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="18">
        <location>
            <begin position="222"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="19">
        <location>
            <begin position="550"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="242"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF0738138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="22">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="706" mass="79495" checksum="54B5F19694B9C767" modified="2020-08-12" version="1">MSTMTDRTLLESINKLKADGSNYREWCVKTRAKINQQRLGKYLKPCRDATGKYLSTLSEEDDLVALFYIQLSIHNDHLKSIQHVETTYDTWEALRTIYESTSEVTLVSLQLQMSKLEWNERTGLDSFADQFQEFMRKMTAAGDATPAKSHINRFLCLLPSRFSNNVMFITRESRTSNMYNNMPAVLAELKLDGERQQLSDPKLRKHIGKTGEALNTTSNLQCHDCNKPGHIRPDCHRRQADEARGIHRRSVQEKPQSSGNNGKDNRYTNGRTGGRGRGRSQRDWRGHDQGNNADDLDNGNDDLFMVETGTPASDHPDDDTWRQTKEEPIEIDVVADELSQYVTCNNEIDECNAISSPVKREAIIDSGATAHMTGDIELLHAVTKCIRAVRLADGHPIQVTKMGDLKIKSTDTGRVATFKNVLYVPTLKKTLVSISRINRQSDDASITFKADECHLKSRNKLSITAKWNTSFLYAIQGTFILPGTDDEANAAETADAMLWHARMGHIPATSMVAVCATTTGGPSNLPKSVTCEDCIRGKITHNSVPKTGDRPNHPLGTCVHTNLWDPAKVATPNGSKYFVTITEDSTNYVWVKFVAKKSDAYDAALEFIPWLERQTGVRLKTLRSDGGGEYVSDKLEEYLKDHEIHHEVSTPRRQWENGTAERMNRTLVEMARTMMLHANATRKWWTEAVSTAAFLRNRTPNTKTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XDS8</accession>
    <name>A0A6G0XDS8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_005780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000076">
        <property type="protein sequence ID" value="KAF0738342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XDS8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021610"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0738342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="167" mass="18138" checksum="E5E7DB83F07CDFE8" modified="2020-08-12" version="1">MFGVKNTQTEMIDDEMLDTEYCKAYRDDPNFKKIVDSHDHTTGFNEAWDSISRVRFNVLRRFAEPIEALQPVEAQAPLEVEEASEAHEPLDAPQTDIGEAQPEALDIADAQPRAEDPEVGAQAPVEVAEDVDVHAQEVADAQATANVNLVAGDDDAVAPLDAAGPTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XDT9</accession>
    <name>A0A6G0XDT9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VLIG-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_005781</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000076">
        <property type="protein sequence ID" value="KAF0738343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014223"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021377"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030383">
        <property type="entry name" value="G_VLIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020864">
        <property type="entry name" value="MACPF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22796">
        <property type="entry name" value="URG4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22796:SF1">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01823">
        <property type="entry name" value="MACPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25683">
        <property type="entry name" value="URGCP_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51717">
        <property type="entry name" value="G_VLIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VLIG-type G" evidence="2">
        <location>
            <begin position="1182"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="683"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="683"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="695"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0738343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="2160" mass="242991" checksum="7CB5723FB5B063C7" modified="2020-08-12" version="1">METTQHDVDNQRTIVNKTASGTSKSEVVKSEVVKSEVEKAHSTPSDSNQLSDRDVIFNASARLALYGITIGLSSDVIGSKPPKQLLSEPNECQLVGAWLIKSTKSIELKSENALSRYRAAVESCGTTIAASLEVSGWGAHLDASDSNKDTHDSQSASQEKSTTVLHITRWLVPTKSFRIAESNVVLSSEAIEAIKMIHNKDQAKRFMLDYGSHVPCGDQHLGGIVWTTERTTSSEAAQARTSEDTHNSETSLSGGVDAGIAKASANYDKNQSTTNSAGDKLSESTNSKDAITEFAGPNAKDFDEFVDRVTNLPESWYLLDRGPAEAMVPVWSFVTVNLFGEKIATRVAPLLQRAWSEEAIRFNDFDIIKGLIDRASHEAENSVRAAIRSQLNDLSALNLDTTAERDLDESVAKLLSMIDDYEKDFGTSILADLLRDRQFPRLLSYFANQSENPRVKSALETLGKYFNPRRVQKLQLETPPITLDDHVRCKLNAASGEKQRGSIASDGWRPTPAQLDEIPSSIVAIVDSVSGVDAGREKLLTQRLGEFWAVTMAELHKRSLKNNDRVILHRIEDLASKLQWSSEEMFTRTLNAHQVRLFAHGIESILAPKTSSATVNSAKEDPVWRSTFLVNVDTSGKKSISHVQTSRVISSTSSLLDTLLHTLVHRLDVRGALYPNVVVNDDDSDYVDSSEEEVDSPREDADGHVDRTNVVPSVYDTSLDLLSSLDVAARATVMKLLLERRFLVPVVSRNGHAKEWDVDPLVLVDTFIGSGYGDVNLSSNTNLLRVVVMSMKPKTLSKAFKWVNQLFHVHSFYAMDKEEEAALPEAVSTAELGWGFFPDRTSDASGKKYIPVTLLHVIGDHHALKSFVESFADVVIVELEDEQASCDVTLAHGWIIQYAQSNADTCEVKKKTPNIRKVLCGFDCSASRIMKQLYKYQTKIEPKTGGEHAHRKLLGDVIAQSKSIPRQVDKKNQLESLPGSVDFRTVRFELRMQLKFAEYAQDRVQRLREAERDLVSRALLPIEQKRYEAYQAETLRPKSASHDLIIALVRLLSLPSADERVAGVMHLERLLRRKCKPNLDLAMAVEREARNRKNTEPSPHTIEEWKKCVNDTNMSSVGLVHLWREISHIYAANPAKPPLLANLAAQHLLDGFPLEMMDGDAGAVNVVWIQGVLEALSDVLGSATVLVLSILGIQSSGKSTLFNVMFGVRLQTGVGRCTRGVSMQLIKCEGHNEYEYILLLDTEGVRAPDFIGLEGSVWRDNRMATFAIVPADATIILTKGESTTEINEMLPIMLTAYERSDLAQEHGGILPSKLLFVFNQNNTNQSANLSHTADTLRTELNKNAQQVEKILNPEPSAPATMTSRAFSDVRVDMTNVDRSDMRVLGMLTASDSPPNDTPNAAFGSDVLRLRDYIHSRVVSDPTWTARTMGQFAKMFSLLNECIEQSDFDFSFTAAVERLAYDQLVEQIEKYMQELTAAYWVQFEAIAKKITARADGEALDESNANTDEQTEKVAREFSLSLDVNMETEISRLRGAVAAFETDKRYKKWWSSYVRPNWNTYMAEQDKHWRQRLRDCVAVKFKYNVVVEKYKREFRRQTNDLFSGGKWERFTEDQKDKEFDRIFKALVRQALRDHEPHHLKVPALVSDVFMSNQNVSQQMEKASELASKSKDGEWSIKKVFENVKESVSDYLNGGNKEDLEDTIVRRVKNEIAKAKVYSDETVKKCIKIAQDAFNTNLVKSKVRGKFYLRLRETLQEELQKKQRVWDMDNNIASRFEATRAEMRDYFDLLGSGCQGMDAFQEAISNWLRRGLQNAFVEELVKFVGDSVKDSRWVRDAKVLQALLDEDLIIKIRDNRIKNVLGHLRDPKSHTTTVLRKLLSKKIEDCAADRLEVFRKVIQEGINLAASSTSVASCDRAVEFRKRLIEQLRTGLQSGSTNRFLDSLPNLSGPAFHFDEQPNDVFVESDDNYVCKPMLDAVSEKLASLAKANERVNVYGDVPEKVLEYIKLASYGIDHGVRPRCGEPCPLCKCPCTREYGHDEKEPEVRHDTIHQPGGLTCQYLAKTTELFAPNCYAAADGYKFLYDDKWYRYTDFDDVFPGWSLPVQSEPLKLREYIFYNHQEQLVEIFNALRPAEKQVKKCSKIPKSYNHSLEDIEKAIKRLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XFJ6</accession>
    <name>A0A6G0XFJ6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Argininosuccinate synthase</fullName>
            <ecNumber evidence="3">6.3.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Citrulline--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_005423</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.5" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000070">
        <property type="protein sequence ID" value="KAF0738812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XFJ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017573"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004055">
        <property type="term" value="F:argininosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000053">
        <property type="term" value="P:argininosuccinate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000050">
        <property type="term" value="P:urea cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01999">
        <property type="entry name" value="ASS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000019">
        <property type="entry name" value="Argininosuccinate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1260.10:FF:000003">
        <property type="entry name" value="Argininosuccinate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1260.10">
        <property type="entry name" value="Argininosuccinate synthetase, chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.470">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00005">
        <property type="entry name" value="Arg_succ_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048268">
        <property type="entry name" value="Arginosuc_syn_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048267">
        <property type="entry name" value="Arginosuc_syn_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018223">
        <property type="entry name" value="Arginosuc_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023434">
        <property type="entry name" value="Arginosuc_synth_type_1_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024074">
        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00032">
        <property type="entry name" value="argG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001770">
        <property type="entry name" value="PRK00509.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587">
        <property type="entry name" value="ARGININOSUCCINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587:SF2">
        <property type="entry name" value="ARGININOSUCCINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20979">
        <property type="entry name" value="Arginosuc_syn_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00764">
        <property type="entry name" value="Arginosuc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69864">
        <property type="entry name" value="Argininosuccinate synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00564">
        <property type="entry name" value="ARGININOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00565">
        <property type="entry name" value="ARGININOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arginosuccinate synthase-like N-terminal" evidence="11">
        <location>
            <begin position="10"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Arginosuccinate synthase C-terminal" evidence="12">
        <location>
            <begin position="184"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0738812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="422" mass="46724" checksum="88F9E3111E30D401" modified="2020-08-12" version="1">MSVKANPGDKVILAYSGGLDTSIILKWLVNKGFEVICYCANVGQFGENFDKVKAKALSLGASNVYIADLRKEFVVDYIWPAVQANAVYESRYLLGTSLARPVIAKKMVEIANAEGAKYVAHGATGKGNDQVRFELCAQALNASLKTIAPWRDPEFIEKFKGRQDLIAYAQEQNIPIDATPKAPYSVDENLYHTSYESGMLEDPMTAPMKSMFKMTVDPKDAPNESETIRIHFEAGVPVKVSNLTTPGQDETDPLLLFLELNRLAGKHGIGRIDIVENRFVGIKSRGVYETPGGTLLREAHLDLEGLCMDREVMKLRDSLSVKFAEFCYNGFWFAPEMDFVRNAISYSQKNITGHVDLELYKGNVTVIGRYSDVALYSADLASMDQEGGGENIEYNPSDAQGFIRINATRLKAFHLVAKNKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XFW8</accession>
    <name>A0A6G0XFW8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_005184</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000067">
        <property type="protein sequence ID" value="KAF0738995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XFW8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000497"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37028:SF4">
        <property type="entry name" value="ALMS MOTIF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37028">
        <property type="entry name" value="UNNAMED PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="3">
        <location>
            <begin position="404"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="370"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="370"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0738995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="436" mass="51017" checksum="3C602A5B74880A90" modified="2020-08-12" version="1">MHVEKQEQSTKILKEELDAREESQATFTPTINPKSKGMERRIDHLWSWHREKQNKLQERRLEAQQHELAETMPSPPCNPKSNQLIQRYPQYKHKIKVEDRLQSYAVTYRSKQIERAREKSFAFKPSLSCHSSRIARVGSVYDRLYSLAKRPAELPTEMTSLCPDKAKRMPPTMDDHAVDVCTRLHDEASAHLEKLERIRQAEQRKLEERMKTPKINPKSLKLAQKLQGCVRTCTCSQPSPPPAKLKRVVPLHQAEALYKKQVQWKRDKQARAIRAREALDQEQFDVCTFSNPYRSSDDSVAIKANDEYFRKAMEWELQKQQRLNEKQQQHLLNKLKECTFHPRTNPCPIEMLSRQRPSLDSVLSNFREESDCLRTPPKDRQRSNVKSAGHGKSSFRISAGEDARILPYPWEEYVTDDGFLYYVNTLTATSQWDFPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XGW4</accession>
    <name>A0A6G0XGW4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_004696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000063">
        <property type="protein sequence ID" value="KAF0739513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XGW4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018956"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35213">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0739513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="225" mass="25899" checksum="E5B4B40822D58C9C" modified="2020-08-12" version="1">MLARATREKQRAGPWSDVEIALIKRLSHDFKNGLLRNVPNGTSIRPWLAIQLRCHPMRISKKFPKESDLLGIHNYTFDEELERSIPTAVKYVRDLELQELDDKFKAQVVLERAGKFRQRRRRRKAKPSTSTKIVKDEPTKTHEKPPVFAWHSHIDDVFHEFKAALALESVEHIPTTIDKEAAQCMTMDCSWTTNDDFVLAKSFPLLSIDAGDATMIEDGNFVVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XGZ5</accession>
    <name>A0A6G0XGZ5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_004710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000063">
        <property type="protein sequence ID" value="KAF0739528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XGZ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010560"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF3">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0739528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="367" mass="40101" checksum="B0F877F14FC6F359" modified="2020-08-12" version="1">MTVGQRATDQVFTWSAPSMDGLPPSARGGHTMLLAGQRLVLFGGHYFGGDGAFVYLNDTHALDLETSTWCQVKCQGKPPAPRYNHSATLVGNKMFVFGGKGGKGTLFRDMHYLDLESWHWYSVTWTTESPSERFGHADVAVGTKIVISGGWDGSSKTFKDLWVFDTESFAWIKPKVTGTPPPPRQGHKMALLDDGRILVFGGYALKASGDLSGEYFNDVYALDTETMIWSRPRTTGDFPLGTFGHTICADSFKVYVVGGWSGTERSPITMGDKVVNETAKALAREQSLRSGDNVSAKSFKAELSKSKYLHVLDCATMEWSCPRSQGLAVANRYGHTCALVGPHLFLFGGWDGNRALHQLVVAALPDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XH83</accession>
    <name>A0A6G0XH83_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_004845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000063">
        <property type="protein sequence ID" value="KAF0739675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XH83"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009050"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0739675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="136" mass="15419" checksum="246751EE55D5BBD8" modified="2020-08-12" version="1">MVELIEVIVKGLCFAYALAIYGVAQALKSQEKDRFWLYMTYVLVMTCPCIWALIRCAREWDARRKIVVVKPKVKKKPDIATKKDPRVGITQAEILAAQRAKAKEIGGIVDVKKKKEKKPPKRKGPPKKKKDAAEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XHA7</accession>
    <name>A0A6G0XHA7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_004860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000063">
        <property type="protein sequence ID" value="KAF0739692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XHA7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020279"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF57">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="1">
        <location>
            <begin position="129"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0739692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="314" mass="36215" checksum="DA6FEB68C621E7A4" modified="2020-08-12" version="1">MKDLRRDSKSVQTLHLAAYVEAEYPTWLDEYLDGKGDSGYDSFLHLLWDFAHRHGFGRRVACPSMLKQKVLEQTQLECAADFWNEFDNYEPRTIFNVDETGIYFDMTNSRTWARKGESSKTDKSQKHSDRMTAVLTIAADGSKHPILFIVKGQQDGRIEQDELATYPPGHSYAVQKNAWMDTRVWETYQRKILQNAVQEPSVVLVDNLDSHVSDKSVKFVEEKLLSTLVPLPKNSTSVCQPLDVGVMGPFKSMLRREWVLEEIHRIRQGTNSVVLTAREKRLASIKRVIRVWEAFDAEVVMKSFRKAIPKVYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XHM4</accession>
    <name>A0A6G0XHM4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_004654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000062">
        <property type="protein sequence ID" value="KAF0739763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XHM4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000689"/>
    <dbReference type="OrthoDB" id="67573at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0739763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="94" mass="10484" checksum="6C545FC418B84D93" modified="2020-08-12" version="1">MSEPKRTVVGYIQDNVGWGFNLVVSNILFWLTGFPTVRDYGYSSENYDENGGIPSGGEGSGVFVITLVLMVICYIVYFGRMVTFLTSKDSHKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XHM9</accession>
    <name>A0A6G0XHM9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS17c</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_004607</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000060">
        <property type="protein sequence ID" value="KAF0739833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XHM9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014238"/>
    <dbReference type="OrthoDB" id="274752at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00364">
        <property type="entry name" value="Ribosomal_uS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01345_B">
        <property type="entry name" value="Ribosomal_uS17_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019984">
        <property type="entry name" value="Ribosomal_uS17_bact/chlr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_uS17_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004123">
        <property type="entry name" value="PRK05610.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03635">
        <property type="entry name" value="uS17_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US17M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0739833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="80" mass="9340" checksum="71731037631AAA56" modified="2020-08-12" version="1">MKPIFGKIVSDKMQKSVLVAVTRIVKDPTYGKYYKKTKKFMAHDEENACNIGDLVRLSQTRPLSKRKRWNVEEILKKAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XHU5</accession>
    <name>A0A6G0XHU5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_004877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000063">
        <property type="protein sequence ID" value="KAF0739709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XHU5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018172"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="185"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="302"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="363"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0739709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="621" mass="72001" checksum="241AD2AADE432FD1" modified="2020-08-12" version="1">MPTNGDVDLVDLSSMPLDTVLLTPEKKSRILSLLHHIQADYQAQTQKIEWQEQLLEAKQRLIDKYEAIAQGNLKSDGKEEHQEDDNLNSSLTLDIDQSFQADLDTTKGSPTTDTAEFSSNYCACSEDTTPTRFDFRSWPSLVRKIHHELSRLSESDPLRRFTQQLCRQVVDLPASNEIFMLRSTLKNLQHQAQAHSSIIQELRRENDDRLSRARHKRQLNLCLQDEMVRLRTQVADLKAQHVRLYAKYNDNQQEYSHLQGDFSSLHREYEELRSSLETCKQDNTSQLELFQTKSEQQIALLREEHKAEREALLETHRRTIDELTRVLKSQETKWSSQINRLLELIDTQEQDIATLHTAPKAKSSDLEQRLAQAEARNLSLQSLIESQKHDLAPLLTAQKAQISHLEKTLVQQEERNLSLLRLIDVQEQDLAILRASSKAQISDLEQKITQQEERNQSLVASLTECQRDLEASKEDVKNYLLECESYKTVQVSLQEDCQRQAKQLQLLAVWKEQAETWQMACLEHEQRVGELKQCVASLRDELRFSKERFVPDISHLLQQHQDPASTINDEVVDKLKLVLDKRIEEYSQDQSKYPTNAPLQHYLSVEMVFLSALRGRLLLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XIS5</accession>
    <name>A0A6G0XIS5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_004414</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000054">
        <property type="protein sequence ID" value="KAF0740182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XIS5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018933"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14686">
        <property type="entry name" value="bZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0740182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="267" mass="29660" checksum="15F46F5DB7A97E1F" modified="2020-08-12" version="1">MNQATSPSNSPSSSSSSSEALAAERLAKRRARSMISQRKYRANQKASNDQLVHDVRALELMTVTLEARLVVLQERQGVSIMVNAIKEYLALFQHGYHPFGPDSSLTQRQEAFLHRIMSPNVEFMGNVGVVPVLESGATFTSLFSNYQVVTQHIQVLSITDDDVLIEANCTIHVQISATTIQSLFPQLIRRHDNSDILDKLIGKALQLPTRYVFVFNIASRQVIRLDIFASIAAAFVEQLQSIDAACDALQGVMKDEVLLRLQQLGYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJL4</accession>
    <name>A0A6G0XJL4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">GPI transamidase component PIG-S</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_004150</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000052">
        <property type="protein sequence ID" value="KAF0740414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJL4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005189"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019540">
        <property type="entry name" value="PtdIno-glycan_biosynth_class_S"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21072">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21072:SF13">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10510">
        <property type="entry name" value="PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0740414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="498" mass="55891" checksum="99A56F20FB557FA2" modified="2020-08-12" version="1">MLHGNKGAISKMAGTRLAILASVLVPILLIAPYAYKLLLVPRSPLPFEAIHVLDLAASTEHLRASLRATETLAILQGKHHASIEFAILPQIKKIQVSSTDISVQDGLNDDAEIDRALYKQLQDLKLADQAVLVLLCRDNADRDASTIKLGAYRHAWTFACRVSTEQQQILLNTLFPPFDASDIKPALKYRWSFSILNEVPQNASLAEAWSNVLDSAMSWVEPFAHTLSTTLADVTLESQFVHYAKLAKTYRQDAQGNQYVTPDDLQQFKSANDFSTSSVLEDREQIFHFMGAIPRSPSLHIRYKGAAAYSFLIPSYGGVTIVPTPQDVPRMMQVFVHHCRLLLGLSLPSSNPVAIIPSKQNGLASWEVDILMRRWLVRHWHATLQTLQSIATLVENMPQMIVLERIQSQVTKALKLVQSIDLNEMESPASRQTHLAILRQARLAVEDAYYDPTMVSQLYFPEDQIYAVYLPLLLPLLLPLGGGLVREIKRYRRKKKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XK76</accession>
    <name>A0A6G0XK76_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_003852</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000044">
        <property type="protein sequence ID" value="KAF0740786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XK76"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017683"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000610">
        <property type="entry name" value="Multidrug resistance-associated ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="162"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0740786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="403" mass="45091" checksum="A2DA997206251756" modified="2020-08-12" version="1">MSLRRLFLLCCLTLNKVKVRDDLLVLIDLVGCVVLRAFGVKYIELVETQIARRIDVHHSMKFASSVLDQWFDLWIQLQGSAIVMIVAVSLVVFRSVLSAGMVGRAFNYILMTDDSIVYLIKWYSSLEMDMIAPERVLSYCELENEDLNSTNKAPFKLTEGAIQFKRVQLRYKPTGELVLRDLSFSIRGGEKIGIVGRTGAGKSSLTMALFRMYPISSGSIWIDGRDVWTVSKHELRRQLCIIPQAPVLFKGTLRQYLDPFGSFDDAMLWSVVSKAGLNKLVGAMPEKLSTELAEKGSNLSVGERQMLCLARALLVQSKIVVLDEATAAVDHETDVQLQRVITTEFVDATVLTIAHRLHTVMHSDRIMVMDGGRVVEMDTPSALLAREDGAFFRFASQGSMLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XLK3</accession>
    <name>A0A6G0XLK3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_003639</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000041">
        <property type="protein sequence ID" value="KAF0741067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005639"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052981">
        <property type="entry name" value="Ingression_C2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47052">
        <property type="entry name" value="CONSERVED SERINE PROLINE-RICH PROTEIN (AFU_ORTHOLOGUE AFUA_2G01790)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47052:SF3">
        <property type="entry name" value="INGRESSION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="149"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="1243"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="1731"/>
            <end position="1864"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="1888"/>
            <end position="2017"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="2179"/>
            <end position="2304"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="2677"/>
            <end position="2712"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="4">
        <location>
            <begin position="2848"/>
            <end position="2913"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="3210"/>
            <end position="3245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="306"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="360"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2716"/>
            <end position="2772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2813"/>
            <end position="2838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="360"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="375"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="404"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="421"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="2729"/>
            <end position="2742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2743"/>
            <end position="2753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2823"/>
            <end position="2838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0741067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="3446" mass="382688" checksum="E7900ABFE6AB7C0C" modified="2020-08-12" version="1">MFESKQNPFVALIVGTEEKHLAAAKGVLAKEFTFGDDTVCEFAWPAREFQAKLHVKEKDSHKERYIGGATISLAAILAEVDAAASAAITKTIDLEFSDEKFKTKKSRGQITLSFEKIGAEIAARSSFAIESTKTVTKGDEKTDKTSVGVSEKTAESATNQVKTHVQGKLRIQALGGGNLAPKTGVDHMMDPDPDPYLIVKVGNVAKTFPQVDNVKTKEFEWGVDAVHEFDVGSDVVDVAVHCKDKDLLMDHYIGGALVNFQMREMLAKKSWDQVIELDFAAPEFKSKAKSSRGHIKLRFSLVVPENPPKEETAKSETTAINPPKEEIKTPMIEQAKSTEATELKAADEPPRADEIAKKLVRDTPPVEKSQETHESSSQQKENQAPTPQSTASGSEIDTPSANVDVEKARDDAKKSPEETRNSSNSIVTPTTTSSQNSAGLVSPARKVVKRKVKIQAVGGSNLAPKTGVGHLMDSAPDPYLTIQVESTVKNFPVLDNVKTTAFQWGKDAIYEFPVSPSAESIPVAIHCKDKDLISDRYIGGALIALNMADFGASNEILERKIPLDFEDAALTKKSAKSRGELTLSFYLIEEIEASPEANLILLKAHSKRQVDENTISKAQSSQNIVETPQVAANSTEKSMEIKPIPPIVVPTKRTLKIQALGGANLAPKTGFEHMMDADPDPYLTVQVGKIVKHFPVLDNVKTKEFTWGPDAVHDFDVVPTDSSITVAIHCKDKDLVVDHYIGGASVVLFIQDFGATNSIVNQKVHLEYVDAALKTKSTTSRGELTLSFYLIDETNVPPLNGLKSLSPRKSMLSARIYKGTLTLIAHSAKGLPPPPRQSGASDKRSDPYVVFQIGSERISCAEVKDGYTTPKWPNAKQSFQIDTTVHGFVDIAIFDKKDDRFMAGTRLRLVDYLANLTNHIQATVAVKCDCNKEMQRTSPAGELQLSLLFIPWDSNQVTWKGAAAGILKLNSVAIGNDDGLYDKDFLVEITIRRQATSVQGYLNFQTSAKASSSSESDSKRISWEDELFDIPYALFLHEKMTKEKSPVVVFALKDKHEIHQEKAIAVNFIPLLDLLGLSGLKQLTLVHPKDSTRIPLEFAVHSAVSPPNPGANFASTPGTLRIFILGAENLTSVLIWTKVKATVVGKSWGRGNCTTEEVDATSDGLIIWNSAFEAQVLPIHVKTADAYSVSLHVSVGTNALNPIELSILELLEKHHNRDFNVDIVHDRVVVCQLRLALAFVPLEIKEALVSPRTSCVDFGAGTLHLVIYKAENLMPDKDVPITEIDPEVRVAIKPRYTKQKEIRSNAKTRPLENAGANPTWNEYLKVEFVPPSDSSTAQISPMLCVSINDIQMPGEEKEMNVVGTAEIPLAAFVTNDCQLFSTKLTLLRDNQATGCVYLSGIYESKTAPDLVRKNCHAQGQKLRLSTPSLDNSFSDSSFFPGRLEILVSMAKDLNRNLLVQYRCELCLSSNVDERIDLISRKSLDASTTDIVWDNQITLFTQTAKSDFLRLDIFQEKTLIGWAKIPISTYSQEPRKTFREYHDVVLIAKETAAVKPRILLELTFFSDQSLQAFVNQSMDANEQGFLYATLEHVESRVQQLTNKKISLRLTLVHDENDENIAPCATFSFQTVTQARITWKQTLALECPANFAKQAITRGSCPLLWYELLDGSSSALGNDAISRDPLAIHSLLCTPNAVLTKRLANSTIATTPRQPVAYTKLHLVYIRGPKVDTKSKTFLDQFTEVLTPNRGTLSMRIIAGRNLTDVDIYGDQDPYIQLQVEPTTYQLAPECAIQAQTGVCLNSGRHPVWNSPVYPLSIHDSNVELVTLRVLDSGEEEQVPDTLIGSCQLSLYSLLKMGESDPKRWNEAWFHIYNDGELAGEIRLEYRFVRDNKTRICMGPQTKYINCQGGKGNLMVKVVAGSNLPCASGMFPAVRLYVDSTKVAHVTQAEKKYLLNPTWNEDAAFEIEWTSDLTTLRTIRVEVVDKAAGTTSTLPIIAHCTVNIAPFVIHPHEIHHGMYPLTAFQMRKDVEQATITLSFQFIPFDSKVSPFDEPLASPEAGQIHIKVVDGVFWSNNAFRPFVSCCFRNALHTQVKQIPSYHSELDEYSYCPWNQSLLFDFNSQDGAKTLPMLDMAIYNEEDTENSIAELNYIPLLPFVLLKGHMNIVWYPLYKQQHLVAQIKTEIQFLKTSPVPKSTLTDVLTIEVLEGRGLRSAQDGDEAQDPYVVLEFLAKRVQTSAHIDGGTSPVWHETFELPLLGLQPDKLPVLSIQVMNQDPNRHGDGFIGSCTWVVPKEVLYDGKLRDVFLTLGGTSDGVDVGKKSNGEIQIRLKRGQMPIMDFGDVDVLQNMQSGEQTRESTNLAGLLYVFGRESKQIQVALVTQNGISNENQWTTFVLSDMAVLTVPWQEEPLKRHLPHLQTTLHLKYPNKSGSVVISPDELHAIFRTPNQEFRHKHAIQGAASDKTLELSLVYVAPTQGVFKVGVAKIESFPTRAGNIYYIDMRVLRNSLWVKTPNVKPSKESKDQLSWKTPVALRELQYTNFREHVPPQLQLVLYMQEAKTDTTWIKVAYTQLNLLQYIVSPSKFDGETVPLTCVTPHSLGQSCVVLSIEFSVVPTTSAIVKPEDAVAAALKLAEGTAELKKSFLMLGGDESKPLDIATLHAATKENSACMHVLQQAADLVGGLDVLFAAMDSNKDGKISWEEYLDRMQTIHALADEAATKPSKLTQNNTEADENGELSDDDSESEGKEDKDVENTAKATAKPTGQPISFQPWKMAEPKQSYWSNVNDDDDIDSVKSPVKSTQNPAIAPMVAMPKTMENNPRDGLQSREKAEPIELPRRKGPDELTVQSWKVGDVSRWLEVDMELPQYIPDFVNASVDGCLLLSLTPEDLDKELKVFQPLHARKIITKINQLRAKNPTMKENGAVTPAEDANDLETSIKIPVETLVKKRAAKSVKTNPVDLNEKGRNEIERSKLEFKAQAKKKAQKAEKAKVDRTARTWTFEYTGEAKPKISQSAAEKVTEILQHDKAKSAYEGAMDEVLAQVMEPPTPLIQIPLITNTDEVVEIVKQAIWRHGATLFEKAKIQRQIEHDAASDFGDDDDENNDKSDSIKSPVELVFGEFCSLKNNGAQWLNENEKLSRLKLQGGLQAILGIRMSWHQFDLLFRRLAGDSEGEVTWKAFHRAFGDPVPGNAMSNDMLAVKEGLVLMIDRLEEHELTLTQAWQAFDRDNSGAISVAEFSTLIQFLTHKEGGEKLTKHQIYLMMASLDSSCDRLIQHAEFMKFLFIIWSHRLMQLQQYSGNDPEHAKLIAARKVALRKALRKNFSRPFRDAMRCMPVTVPGPFQNLLDKFHLHYASNETPLQVWQVLKGEHSASGAAPVALKEKTKSKKVASGKNSVTLTKLKRQQGPKRDHAVLRAPARVDLDSTQELIYDNKTHKMTSGNLHCIKLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XLX0</accession>
    <name>A0A6G0XLX0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_003486</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000037">
        <property type="protein sequence ID" value="KAF0741377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XLX0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010583"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0741377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="300" mass="33920" checksum="2CDD7B398899F03D" modified="2020-08-12" version="1">MQVVREIINMDLANEMDCQAMMEKMSFHVAKLLDRVCTEAGLSCPGMGELKLQRTKLLEKELDVVACVSSTPFNRPPHNQDTLQRILQHLRTLEETRDFHAKLRVCQSELKLDTSYSLETFAYGTTPFSTWIHIFSHPHMINCVAKIRECGNQEACTIFGSSTGSLVFFTSLLCGIPVRGVEILPYLFSIATSTQSLFCVDSVEFLCRDMLDIDISQTQLLVLTSQCWEDELLAAVVEKLRNELPHGAIVLDYKPSLQAVADLFRVVETLTAPVSWNPSQCFYLFEKLAPNLKMNCLNQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XMP1</accession>
    <name>A0A6G0XMP1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Multiple inositol polyphosphate phosphatase 1</fullName>
            <ecNumber evidence="4">3.1.3.62</ecNumber>
            <ecNumber evidence="3">3.1.3.80</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">2,3-bisphosphoglycerate 3-phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Ae201684_003393</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(2R)-2,3-bisphosphoglycerate + H2O = (2R)-2-phosphoglycerate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:27381"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58248"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="3.1.3.80"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:27382"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>1D-myo-inositol 1,2,4,5,6-pentakisphosphate + H2O = 1D-myo-inositol 1,2,5,6-tetrakisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77115"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57798"/>
            <dbReference type="ChEBI" id="CHEBI:195535"/>
            <dbReference type="EC" id="3.1.3.62"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:77116"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>1D-myo-inositol 1,2,5,6-tetrakisphosphate + H2O = 1D-myo-inositol 1,2,6-trisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77119"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:195535"/>
            <dbReference type="ChEBI" id="CHEBI:195537"/>
            <dbReference type="EC" id="3.1.3.62"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:77120"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>1D-myo-inositol hexakisphosphate + H2O = 1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16989"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57798"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="EC" id="3.1.3.62"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:16990"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family. MINPP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.62" evidence="4"/>
    <dbReference type="EC" id="3.1.3.80" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000036">
        <property type="protein sequence ID" value="KAF0741729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XMP1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020852"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034417">
        <property type="term" value="F:bisphosphoglycerate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052745">
        <property type="term" value="F:inositol phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016274">
        <property type="entry name" value="Histidine_acid_Pase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF8">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000894">
        <property type="entry name" value="Acid_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026319903" description="Multiple inositol polyphosphate phosphatase 1" evidence="17">
        <location>
            <begin position="21"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="46"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="238"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00043691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00043832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF0741729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="416" mass="47449" checksum="ADD6262735F55074" modified="2020-08-12" version="1">MCQEFLTTVLLAALSSSTLAYPTGLGTKTPYYPQALDFEELPPPTCVPVQVNMVLRHGSRFPTIKVIRAIEATTRKLQARMISLPTWLETWNVETYYPVDEAGQLAPSGVQEMIALGQRIRRKYARDFASHYAKPHFTFESTWKDRTRESATSFAFGFFDGHQPVHYEVAPKGADTELRFFDNCPAYDHAVELNATATLQYSLFANSEAMQRNLKLFQEYFNLSSLTIKDLDTAYDACAFDVAVYGIFHHWCSLFPDDVLHSMEYFKELKQYYRKSHGNAMAVDIAAPLIRDIVESMRNYTDGKGSVQGHFRFAHAETLLPLVSILGFHKDEPPLMASTNAYDRRFRTSELSPFSGNLAFVLYACENESKHMVQVVLNEKQVESPGLGCIYCPLTHWTCHYDPWISHWDFQAQCTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XMP4</accession>
    <name>A0A6G0XMP4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ae201684_003337</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000036">
        <property type="protein sequence ID" value="KAF0741664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XMP4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017654"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000009">
        <property type="entry name" value="Probable E3 ubiquitin-protein ligase HECTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF440">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NEDD-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026001262" description="HECT-type E3 ubiquitin transferase" evidence="12">
        <location>
            <begin position="24"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="13">
        <location>
            <begin position="84"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="14">
        <location>
            <begin position="317"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="9">
        <location>
            <position position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF0741664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="654" mass="74464" checksum="8E0DD28169D0C09F" modified="2020-08-12" version="1">MRDRLAWKFGLLVLPTMVVAGDGQNLPQWIAWTTGGVLIVIVLYYCCRKAGFDESLQQPLLGGQFNEDGQPLTRQDVQESKEEIEGQWNCEVCDFHNKMSAKTCVLCGTDKGFKLGLSTPSPRRSLSFKESTLNGVGTSGSFNRTRSFAIRRLNMLNSRQRGARNRGDWVRVVGKDGKRHWGRRDVQDAFKTKDPTSLEAGTPRSVSTAAPSLDLARQHSLAFVSQLAQTPRHPEGRMTFKEYREVDAAVASRGYEISEQDLEILEQVAALPFKDKYSWFLEQTASLIRPWEDGHLKMRVHRENILVESMEQLLGVQMEHIHMPLRIEFIGEVAIDAGGLEREWFALVTEKLFDETIGLFMCAHVESLAYVINPNSVEASADHLLYFRGAGRLLGRALLEGQLMKAHLALPVLKHLLGVPISFSDLEFVDHEVYRSMKWMKENDGVEALCLDFSVTNRRINGEIEVIDLKENGRNIEVTDANKLEYIYLRLRYIMLESFSEQLQHLMAGVFEVIPQELILVFDYQELELVLCGVPSIDLADWKNHTQTSDDMAAELLAWFWEVVESFNDEERARLLQFTTGSSRVPVQGFKALTSYDGRICHFTLKAVPYPDNAFPRAHTCFNRIDLPKYKTKKELEDIMSHVINMEVTGFTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XNT9</accession>
    <name>A0A6G0XNT9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CCR4-NOT transcription complex subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_002931</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000032">
        <property type="protein sequence ID" value="KAF0741990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XNT9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014027"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039740">
        <property type="entry name" value="CNOT10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12979">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12979:SF5">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="396"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="268"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0741990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="730" mass="80101" checksum="7CA273106DA48A7B" modified="2020-08-12" version="1">MDGGSNLSSVAQRAQANFAAGKYAEAVDLLSQLSSWEERGSEKKDDKKAKDAGKDKGGPMKTRVQHNLALSQLLAGKSKFADFENVVMHLLSEMQVSVSQMQQSQGDSGSNAMLGLGMKLRKDKDWDDEQDGFDSVKGNSVFSGMNLSFQTLAMERDASLLRYNLALVYFRQKKYAAAVSTLDVLLRAIEPMDENVAMHICFLYLDVILHCSRSSSISESAPLRHKAQAIITYLESPHGFNGVIAPSTEDQKSKSAFEANVVEFKFRLHLYKAKLALLHDNLKNAKKEVKTAMEIFQKEIKSKEKPGDTINAVAVPIGVGSIFHPPLSVQNSSALFLKANMEYLRRNFKKCIKLVASCKRQSVDEPIFLNNLGCIHNQMGHHQAAQSYFAKALEATSPRPKPGSKATEPSSSPLSTSTQAEILYNNGLQLLVLKKYALAFRCLHAASKMFFNRPKLWLRLGECCTASYAAQRESIPSEYKNSLVSSVVGHGAHRRVVLPVRSPTDEITVDTTTTSDAVPTMNLPFAVKCFRNALLLSQQMLEAKSSEPVSALSDQSAGEGANGDAPRSLSLVESLDLLRQKALVNLVYSYLSMNAPELAISTAKELLALGTCTAANRFLVRSYYAEALCMLSRSSEASVYLKPNEMVTLADEYAREAKIDASTAQAHLHVNIATAAIFQKNTSVADQSVAQAVRLAPTSRHTLELLVYVLLRKGNTKKAMQVLKEARVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XP26</accession>
    <name>A0A6G0XP26_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_002668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000029">
        <property type="protein sequence ID" value="KAF0742264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XP26"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009391"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0742264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="214" mass="23640" checksum="3E08AFB7589AB7C9" modified="2020-08-12" version="1">MMATSKENTPHVQRKLTFQGLSIKQEEAQFNANRVVSSRPDAMKNPTPISSKKTSSSKRRALGDISNNTSASLDKKAQPAFRTPLKSTDGTSQSSSKNVEASAAVELASKLSLKVHSEDDIENAYGGLPESDNMLHLEDLQKQVDLEILDWQKEVDQAMALKKDDFDSLHDGVCEFQPLVIVDELSSPDEIHDGERLEVPPLFNEGSIEFDIID</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XP70</accession>
    <name>A0A6G0XP70_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_002752</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000030">
        <property type="protein sequence ID" value="KAF0742077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XP70"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000001"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007802"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008222"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008700"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024395">
        <property type="entry name" value="CLASP_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040899">
        <property type="entry name" value="Fas_alpha_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041550">
        <property type="entry name" value="FASI_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982:SF21">
        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982">
        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12348">
        <property type="entry name" value="CLASP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18325">
        <property type="entry name" value="Fas_alpha_ACP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18314">
        <property type="entry name" value="FAS_I_H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CLASP N-terminal" evidence="3">
        <location>
            <begin position="17"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid synthase subunit alpha acyl carrier" evidence="5">
        <location>
            <begin position="312"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid synthase type I helical" evidence="4">
        <location>
            <begin position="428"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid synthase type I helical" evidence="4">
        <location>
            <begin position="561"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="680"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="688"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0742077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1192" mass="130815" checksum="2D9BF8094A44DF68" modified="2020-08-12" version="1">METLLKQITTYDVHAPWSEQLQALADIKAVVEQVLQVDSRDAVVDTLTILTEPFKTDCWIESIRADVVHRARGFLSGLATTCGFALGQFVDDMMVSLVDAARSHIEKICQAGDDCVAVLASPSRYNVNKLIHTFDTVRGDDVRLLIMSQLELILKSWSQADLDPYLEGIKNVLAKGLDDKSESVREKARDTLCLLRGHETFNISQVSLSSEFGLGAGRTDSVVMPSLLFPPVSFHINEAVAKSWLNKVVADYVKFAGVSISMGGAGQAIGGGMPMMMQSIAAAAPVENVPDMDITAAYGLKAFLAPKFAANNKPGKYLTSTFVKMLSAKLPGGFLASQLRACMAQERCFGLKHIEIAMIHSLANAPDARFATEADAKTWINLVIDEYGSVSSAMIPYASKAGGTVSAGVPMMGGGGSISSAALDALKAQMSTMMREQVNAYQAFMKFDSLATLKKTNADKVTRRELEKRIDLWVSEHGEYDEKGIQPKFDAKKIRIYSSYWNWVVQDALDLYYRTYAQGESEETGVSDRDSHLAQMSAFLNTDSTDLASMGEPETWHRPFLCNHATPELLAATEFFIARQQANGNSDFAQAIQLLNDAVEKWLERDPVHGQLLQPYQPHGTIEANGTISYKEVLRGATSVDYAEELSRGFHCRSDDFKLVSPKSGHSAVNLIRGIESADLTDDGADSGNANSVNSEPTTQRRSAVRRGARANGSKLYGLKAVLRKAKRAKSFGESFTTLPYVHVRKNDERDPTLRVLHEGLTKELLLSMPEIATGGVSFVGKNALVTGCGCDSIGSEVVKSLLEGGATVICTTSSFSSKSTKFFRSMYENHGARGSKLILFPFNQASSKDCGALVAHIYEQLNLDLVLAFGANSGPTLSAIDFKSELAHRIVLTNTYRILGKIIDYKRAKNIRTRPCLAMLPLSPTHGTVGGDGLYTEAKLGLEALMNKWHSEGWKHYLTIDGAVIGWTRGTGLMAGNNMVSACIEKLGVCTFNQVEMAFHLTSILHPRMVAAAAKSPLWVDSGGGMARLHDLKVQTDNIRAAITEESKIRRASVEDRKKDSVTDVVDAEEPVWNRANMYYADTQVKSLYEENILKHSGIRVIEPELFEGYDPKKKIILQQVDKNMRPIEVASREEGLESQKKLGEDNCDVSDGSWMLRLGQGAVLSIPRNLHLNRWPNSNWLGRQALWYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XP74</accession>
    <name>A0A6G0XP74_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_002803</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000030">
        <property type="protein sequence ID" value="KAF0742131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XP74"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000215"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042759">
        <property type="term" value="P:long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03506">
        <property type="entry name" value="Delta6-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000007">
        <property type="entry name" value="Sulfite oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353:SF19">
        <property type="entry name" value="DELTA(5) FATTY ACID DESATURASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="FATTY ACID DESATURASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015921">
        <property type="entry name" value="FA_sphinglp_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="6">
        <location>
            <begin position="23"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0742131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="471" mass="53626" checksum="2C0643E02F48C010" modified="2020-08-12" version="1">MAPQSELRQRQGAAGAGASKEDKKTFTWQEVAKNNHAGSAWMIVRNKVYDVTAWVDKHPGGREMVLLHAGRECTDTFDSYHPFSDKAEQVLAKYEIGTLTGPSEFPVYKPDSGFYKECRKRVGEYFEKNKLNPQDGFAGFWRMIVVVSVAAVAYYGMHFSNIFTVQAIAAVVFGFCQALPLLHVMHDSSHAAFTKQPFIREFAGRLFMDWFAGASMVSWLNQHVVGHHIYTNVTGADPDLPVNLEGDIRRLVTRQVLLPMYRFQHIYLPPLYGLLGLKFRIQDFTDTFGTLTNGPIRVNPPSTSQWVQLILSKSFWVFYRIYLPLDVFQMPVKTFLYVFLIAELFTGWHLAFNFQVSHVSTECTYPNGNEVKTNLDDEWAVSQVKSSLDYSHGSWFTTFMAGALNYQVTHHLFPTVSQYHYPAIAPIIMQVCKEYKINYPVLPTFTAAFSAHMNHLKEMGRQGVFVSVHMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XPX0</accession>
    <name>A0A6G0XPX0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">L-ornithine N(5)-monooxygenase [NAD(P)H]</fullName>
            <ecNumber evidence="4">1.14.13.196</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_002573</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-ornithine + NADH + O2 = N(5)-hydroxy-L-ornithine + NAD(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:41512"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78275"/>
            <dbReference type="EC" id="1.14.13.196"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-ornithine + NADPH + O2 = N(5)-hydroxy-L-ornithine + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:41508"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78275"/>
            <dbReference type="EC" id="1.14.13.196"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.196" evidence="4"/>
    <dbReference type="EMBL" id="VJMJ01000027">
        <property type="protein sequence ID" value="KAF0742477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XPX0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009377"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025700">
        <property type="entry name" value="Lys/Orn_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38663">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38663:SF1">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13434">
        <property type="entry name" value="Lys_Orn_oxgnase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0742477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="496" mass="54924" checksum="946EF47A3C017E9A" modified="2020-08-12" version="1">MATKANTSNESVIPLLVIGAGPHALALVLNLLEEDSSAEFTEPETVKMSFWRSKLRGRHLSKRDLRRSIRVLDPSGTWCSTWNCNFATFGISHLRSPVSVHLDPLRPDGLRDYAVATNQLETQVSDPPQSIHIGQRSREFTNNTSIFNETDRQFLGCPSQKLFAAFNRQLVKQYGLDTLVQKTRAKTIEHLPDRTFRVTCDDGATLLAKNVVVAIGTLNIPRIPTWATPLRATDAKANVIHSSELVHDPTFPKRVRHKSILVIGGGLTSVHLTRQMLKWGAHHVTLATRKATLIVQPYDVPLDWLSPLLRQKKLAEFYAKETPEAKLACIREARRGGSVTKAALTDMQAVTTPDNFELLPNTTVNRVEQTADGRLHVEFKSSSMQVDVIVLATGGDIDVAKEPLFDRVRDASPVIVGGLPGLDADLRWALGMNLFVMGTYAALQMGPVAGNLMGARSGANRLGEILLEELLPRNEQTRQHHLRALCGKENLYDLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XQC7</accession>
    <name>A0A6G0XQC7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transketolase-like pyrimidine-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_002596</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alpha-ketoglutarate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000027">
        <property type="protein sequence ID" value="KAF0742501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XQC7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012303"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02016">
        <property type="entry name" value="TPP_E1_OGDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000036">
        <property type="entry name" value="2-oxoglutarate dehydrogenase E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11610">
        <property type="entry name" value="Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1150">
        <property type="entry name" value="TPP helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042179">
        <property type="entry name" value="KGD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031717">
        <property type="entry name" value="ODO-1/KGD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00239">
        <property type="entry name" value="2oxo_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006914">
        <property type="entry name" value="PRK09404.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008907">
        <property type="entry name" value="PRK12270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152:SF4">
        <property type="entry name" value="2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="2-OXOGLUTARATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16870">
        <property type="entry name" value="OxoGdeHyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000157">
        <property type="entry name" value="Oxoglu_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="6">
        <location>
            <begin position="576"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0742501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="960" mass="108631" checksum="5FB70DA50F4881BE" modified="2020-08-12" version="1">MRVRYCSTDALDDSQTTSDGKNGKTVRRTSPDLLRSQEETRRVQLLIRTFKQYGHFVAHIDPLRKFEKAPELKKWNWGSRWLEKPYFDDFNLQSLAHSATLELGAHGFSESDLDREFFIGDDLSIGPVATLRDIVTQLRELFCGHIATEYQHLRNREAALWIRDSLTKYKDHEFTSQEKTNIFNDMLQAELFEKFLGRRFSGAKRFSIEGGESLIPGLKELLEAASDMGVEAVYMGMAHRGRLNVLANVLQRPLRSIMSRFQPYLPDEPEYPNNSDDVRYHLGTVSHLTMRNGNTMEVKLTANPSHLEAVNPVVLGEARAFQDELGDFDRSRVMPLLLHGDASMFQGSVREAFGFSGLEDFKTGGTVHVIINNQIGFTTLPKQADTAIYCSDVAKISRSPIFHVNGDDPEAVVKVMKMAVEFRQKYKCDVVVDLVCYRRHGHNEQDSPEITAPVMYHCINQHPTVINMYFKHLQSQGHLNVEECAAMVAKIEMDLASEHEHSKTSPSFWDNSGDHIKTIDNTIGEHGENGSTGVDRKLLEEIGAQTFRIPTGFTAHKKVEAIMNNRLRAVETGARVDWATAEALAFGSLLAEGINVRLSGQDCERGTFNQRHAVLYDQFEALSMRNVTYTPLNELSLHVLEAKVPKYEVPTNTNAKIQVCNSPLSEEGVLGFEYGYSLQCPNALTIWEAQFGDFANGAQTIIDTFIVSGEQKWNCHSGLILNLPHGYEGQGPEHSSARIERFLQQANEDSDYFTKDQVKADLDANIHVVIPTTPAQYFHALRRQVCAPYRKPLVMFTPKYLLHHRPCTSELNDFSLDTNFQRVLPAHHEDLKRMVPNDQVRRLIICCGKVYYSVLQSMRGRNIHDVATARIEQLVPFPFSQIAQIVQQYPNADLLWVQEEPKNMGAWSFCQARLATVLHTLGDTRRIGYVGRPPAASPATGQYEVHQQEMRTIVDEALAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XQY5</accession>
    <name>A0A6G0XQY5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Potassium channel tetramerisation-type BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_002255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000023">
        <property type="protein sequence ID" value="KAF0742858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XQY5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010283"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18316">
        <property type="entry name" value="BTB_POZ_KCTD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499:SF136">
        <property type="entry name" value="GH08630P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499">
        <property type="entry name" value="POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Potassium channel tetramerisation-type BTB" evidence="2">
        <location>
            <begin position="67"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0742858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="405" mass="48366" checksum="8EC83A290B49B2C4" modified="2020-08-12" version="1">MDDIKEKYRQEWEVLEREEKALDLEKKKLSAEWVLVEKYQQCYEKDRATFEAMVAEKFDFMPPDEVVQFNIGGKLFKSTVKVWTRDRFSILAQLCTTSPKLARDARGHFYFDRDWWIFKYIYAFLRDKTLPDSLDVLRDLYYEASYYRITLLRHAIEAFLKNHTTTDVARVHHSYIPSNDAPLRQYVPNVGEREWSSQKQSHNSPPQHHTAAPPQGKQRRQSISKGADIHVRPPPPRVHPFRHETTTSRLDVQSAPPSSAHPHPPLYHQRGYDPALDFIDHRRHPGSYPSHRGYGDGYTDPREYSRESKYQPDRRHGQHYDRHQDDDYRRGRDYDRYDVQPRHNPVERDDRWHYDQREASRGHYQPDQRHYHDSYASQRPLSPPLADPHGFLSRRKQYSMSDIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XRX8</accession>
    <name>A0A6G0XRX8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Lariat debranching enzyme C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ae201684_002167</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the lariat debranching enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000022">
        <property type="protein sequence ID" value="KAF0743110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XRX8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009966"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008419">
        <property type="term" value="F:RNA lariat debranching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00844">
        <property type="entry name" value="MPP_Dbr1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007708">
        <property type="entry name" value="DBR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041816">
        <property type="entry name" value="Dbr1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849:SF0">
        <property type="entry name" value="LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849">
        <property type="entry name" value="RNA LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05011">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01124">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lariat debranching enzyme C-terminal" evidence="13">
        <location>
            <begin position="234"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF0743110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="362" mass="40613" checksum="B50A0D535764905F" modified="2020-08-12" version="1">MRIAVVGCTHGELNTIYAKIEQINATEEPIQLLLCCGDFESIRNDVDLMCVETPPKYLKYGDFIDYYTGAKVPPVLTIFIGGNHEASNYLQDLYYGGYVAPNIFYLGSAGVVQVNGLRIAGFSGIYDERDYKFGQHEKFPYSKKTRRSIYHTREFQAFQLGHLKEHIDIVMSHDWPRGITTFGDATHVYRSIPTLEAQVVAGTFGSVAGERVLHTLQPAHWFAGHMHVKFAADVAHDTGKTTKFLALDKCPHRDFMDVVDIPAPQESNTVKLQMDLEWLAVLRATHHLSSAQRIRPPLPETPLPISPADMSWIESRLPSGQQTDWITSFQFLPSASIGNPQTDELLALLDLPHVVTVPFQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XSV0</accession>
    <name>A0A6G0XSV0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_001729</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000013">
        <property type="protein sequence ID" value="KAF0743585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XSV0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019740"/>
    <dbReference type="OrthoDB" id="68037at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051604">
        <property type="entry name" value="Ergot_Alk_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43162">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43162:SF1">
        <property type="entry name" value="PRESTALK A DIFFERENTIATION PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0743585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="620" mass="66796" checksum="2B8B6A681D47B10D" modified="2020-08-12" version="1">MGTITLRKLLGHRIVAVPDASTLVGRAIVLALQEQNDMSVVIQAGIPPGAPAEATKALRCLSRVSLVPLAPGDAVGLRRFLSGAHVVFIAPSWASLSATRQLLSLAHDLAVPHIVLQSWLLAEQPTTATDADSTPPNAIHQLETHLQDLRPIHSQCTIVRLPFLLDLLVLDQNSLRLAKQVVAGLTPTARVPVLGLDDAVAALSAILLHSEAHGGLTYNLTHPQSTQSMAEMVAALSTALNCSISYRQVGPATWANCWVAAGAPLWFAPYTTVLAMQPDDLDDDVICTRMRCMTTLTCDAERLLGRPPTSPGMWWHHPRDLQAAPALPTRFFVVGLNERLGALVASALVNGDNTTVRGCDNLLGTNAVPNGVAGVDWVEGQLERARDVKKMLAQTDIVVLLPSRATAVTVLPSFLRGAKQAKVAGVVLLSHEFAGSPAWDSPFQKHKHAESLLQRSDLAHCVLRIPLLMEATLDLRQVVRRHRHRLPCAKDDCVLAVVAAEDVARALALAARQFPLHEGRLYADLRGDCVRWGDLKEAIGISTVPIADPAPEIDGVLAELGDVGLAYWSAFHFVDYVHWCDTAVEGRSPGGPSIAWTLAFNEPPLSFAEWCGRHAENLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XTN6</accession>
    <name>A0A6G0XTN6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_001634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XTN6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000783"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0743995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="122" mass="13197" checksum="3B6044A8E9CB1AD9" modified="2020-08-12" version="1">MAKVASEQSIAALSMEPRDEDEEEEKIGAMAETGSVSSISVVTQGPPLDAAPPRIEGLRKQSSYKNENPWNRPRTGKKISFVDEGGSNVPLHEITYSKFTHYSRVAQTQAVPPPPGGCCVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XUP3</accession>
    <name>A0A6G0XUP3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ae201684_001314</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000010">
        <property type="protein sequence ID" value="KAF0744173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XUP3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016887"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000009">
        <property type="entry name" value="Probable E3 ubiquitin-protein ligase HECTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF440">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NEDD-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026248784" description="HECT-type E3 ubiquitin transferase" evidence="12">
        <location>
            <begin position="22"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="13">
        <location>
            <begin position="165"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="14">
        <location>
            <begin position="329"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="71"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="9">
        <location>
            <position position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF0744173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="665" mass="75456" checksum="3B0726D8C6D05862" modified="2020-08-12" version="1">MRVFQPAVGLAALALAIMAAAQRPADISPGIVGHDEAHQVPAVHSGEHGVGYQKTTRVRRTSHYRHAPYAQNHRQHRQLNERNETSTTETIKKTRKPSSTLSEAEKHAIEAKLSAEMVAFGVVILVGVALYYNQLRSYDQLRAQDDPMQFLHGLRREDMEDIALEALKWQCTVCAFHNQDQRVCCSLCDSKRDTNIAVVDMTFQQKSARARNQWRRHVDDTGTVDWVESDKPVYKGPHYIAAAKMETSENEWSLSLEPLSSANATRAVDGADMPTWWLHQLQELSAQSFSLKYAWLLTQISHSYKGYFKMKVYREKIIEESLEILMIVPPDRLCTMTRIEFLGESGIDAGGVLREWYSQLTQTIFEPSRGLFIAANKAEQSYWINPESAIDHGPNQLRHFQAIGRLLGGAIVNGQVLPFHLSLPLFKILVGTPLSFEDVQHLDLNVYNSLVFIRDTDNVDDLALDFSYTTTKHELVDLVPNGRNIPVTLANRDEYVDCMVRYLLLDQVRPQVEALVRGMNEVVPPELLLPFDHKEFELLVCGFSLIDVADWRTSTIVSTSMKKSKCIHWFWDILEHELTDSDRAKLLRFVTGSSRVPLQGFKGLTSYDGNLCPFTIQAVAYTRGAFPKAHSCFNRIDLPIYPTRELLHEALIALVNLESTEFTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XVK0</accession>
    <name>A0A6G0XVK0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_000988</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XVK0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004424"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052050">
        <property type="entry name" value="SecEffector_AnkRepeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586:SF3">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0744512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="342" mass="38433" checksum="7358C088326B093D" modified="2020-08-12" version="1">MTILDVLLSPDLLCTVCDFQNGTYHPNHPLKTIPTPRIRRGAVFENWAKEDLKRIDGAISPWLAIHGLCRLPSLLHVVQRRIVAIHAVYFGHTRTLKALLKLVTFDSICENLIDWAAFHGNLEVIQFLDAFCSNAKQTRLFWCVCSDFAMDLAATEGHLHVIQWLHQSVHRRNGCTAHAIDGAARNGHLEVVQWLFLHSKPCTAKAVDTAAAAGHLDVVKWLTHRGMPATKTAMNYAATAGHLEIVQWLDANRSEGCTTEAMDGAARHGHHEVVQWLHLHRREGCTIDAVDGAARNGHLDVVAWLLVHRREKFTKHAIRRATQNGHKDVADFLRHQRSCVIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XWA0</accession>
    <name>A0A6G0XWA0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_000731</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000008">
        <property type="protein sequence ID" value="KAF0744825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XWA0"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0744825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="157" mass="18267" checksum="BDEB6F467F5E2013" modified="2020-08-12" version="1">MSTWPPNKTDLSRLESLMLSSERPRGGSIATASELNEWRSASKANSRMVAANHSATCICRQRSFVYDEKYTRHERPRGGSIATASELNEWRSASKANSRMVAANHSATCICRQRSFVYDEKYTRQCLENVCCLRDLFVIEKRVDWWWYMRYTTLELH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XY01</accession>
    <name>A0A6G0XY01_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_000436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XY01"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017302"/>
    <dbReference type="OrthoDB" id="2100988at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34286">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34286:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0745417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="66" mass="7269" checksum="59DBF8ED2A07130F" modified="2020-08-12" version="1">MGAVTKYPYPKNVWSPAGGWWNEPKNWKNRTAILAGVMVALIVPMASFASKNATTFSHATKKSDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XYQ4</accession>
    <name>A0A6G0XYQ4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sugar fermentation stimulation protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_000076</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000001">
        <property type="protein sequence ID" value="KAF0745623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XYQ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011474"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22359">
        <property type="entry name" value="SfsA-like_bacterial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00095">
        <property type="entry name" value="SfsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005224">
        <property type="entry name" value="SfsA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040452">
        <property type="entry name" value="SfsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041465">
        <property type="entry name" value="SfsA_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00230">
        <property type="entry name" value="sfsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30545">
        <property type="entry name" value="SUGAR FERMENTATION STIMULATION PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30545:SF2">
        <property type="entry name" value="SUGAR FERMENTATION STIMULATION PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03749">
        <property type="entry name" value="SfsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17746">
        <property type="entry name" value="SfsA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SfsA N-terminal OB" evidence="3">
        <location>
            <begin position="84"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar fermentation stimulation protein C-terminal" evidence="2">
        <location>
            <begin position="156"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0745623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="36549" checksum="6E22CC67F906C52A" modified="2020-08-12" version="1">MVMATQRQLRSSAKTRALHTEDVLPLKKPRRAPASTEVDTEPTKTSSKKSKPSPKRVPSLIATTPVEGPQVLHAFPELVSGQLVQRYKRFLADVKLDDGTVVTVHCPNTGPMVGLLDQPMAPVQLSVSSNLTRKYKYTLEMISVDDVWIGVHSASANRMVETALRNGWMPDVAGPDRRYTSLQAEVKHAKGSRVDFVLESVSTVDAQDVQNIYTEVKSVTLLLPGQGNDGAAHRRAVFPDTVSTRASKHVEELIHRCAKSSTDRAAIIFLVQRGDCDSFSPSMTHDPVFAALCREASEKGVRLHAYACDLVPASRHVVLLKSLPIVHEDAGSKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W3X1</accession>
    <name>A0A6G0W3X1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_018979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000370">
        <property type="protein sequence ID" value="KAF0721699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W3X1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017886"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0721699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="507" mass="58417" checksum="1C4B22119A747341" modified="2020-08-12" version="1">MTKNEASGQANGQQNASLPRVDYIHVLIAKARQTPCSREECAYPFLYQEMANLCSDCSAFNCCDKCSKLILQLTRMSESHENLNATALSGESIEDMYDASFLDDIEGINDAYMVEDLENLNEDTALEGNQDENEDTTTQATANVSIAAQRQRLSRDTKKQLIRSFYERIEDLERHLKFVKAKYEREKQIDEYRAVILAAQAHIHKTMRINSNLKKKITGRRQLRSFLEDWAASKIPQRNRRSPMETILLPDDKGRRNGCIYMTNRALTLSREKYPRRKTVEEEVDDTIHVKLHLGEDAQGTCIDAFECQLQFTIDANFENVAKSWWFDLIESTPILRSTVVEKFGDNIMYVKQEHERLKYKRLLVAGVFLDDENDRITITQTGISLDERFPFREGETRSNGIQWIVFQHVTDRLTIVRWSILSYCPVSAHGPLSLYRMAEEMRCDVRVNDTEDTLLAKIQGTIERAVMGLKHQFITRCSRFKLEPSTMGSRDLPIESLSDFNVDLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W416</accession>
    <name>A0A6G0W416_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL29m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_018933</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000367">
        <property type="protein sequence ID" value="KAF0721755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W416"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020441"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00427">
        <property type="entry name" value="Ribosomal_L29_HIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038340">
        <property type="entry name" value="MRP-L47_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_uL29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010729">
        <property type="entry name" value="Ribosomal_uL29_mit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_uL29_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21183:SF18">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL29M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21183">
        <property type="entry name" value="RIBOSOMAL PROTEIN L47, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06984">
        <property type="entry name" value="MRP-L47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="Ribosomal protein L29 (L29p)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0721755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="149" mass="16942" checksum="BDE1DFEC0735AAEB" modified="2020-08-12" version="1">MLRRAISQVVGVSARNPICSRHISSTSSVFAADTSDKKLTGTIDQFFPTMGVVDGKNVKRTAPVVGGDWKAWMLRNKSTEDLHKLWYVLLKERNALLTEQAECHARNMVFPNPFRKTKVRKSMARIKLVLHERSRIHQHNQATKNSSDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W4M5</accession>
    <name>A0A6G0W4M5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_019173</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000445">
        <property type="protein sequence ID" value="KAF0721343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W4M5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019854"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0721343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="408" mass="47502" checksum="4AD3E3A08483D7C2" modified="2020-08-12" version="1" fragment="single">MLPVDVILKIAFLLPDFKDVFALIDIFRPQIAFEPLEDLYQLGLTHDHSSLWPRLTLDCSMNDTMSITLYESILKLYSHVLVVDSWYSVDWLKKHLNPTTTIEWMAQEFPVTLENIHDWADLPITRLHLSIERDTPQMWKKALPRMHHLKSLSIGNSSGDIEDIYKIVAESAQITELEVNPNGFEVDNAELQHLIEWFHRQPVRVYADSFTNWKLLDYDLRQELCDVMFNCPTLDRLALTDCDLDDMDFSEFSFSMNTLQLYEFCLWKDDLKLLASRLKDSKLTHLELDGYLVGDDFHGMDSMDYWDYTCGMECLFNALPSTSIKSLVITGDDVWTDNRFYLIPLLFPSNCRLEKLAANFSYSSPKSRIVEALALSIRKNHTLYEFHLLKSKISIVDMRMLIQSISDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W6A6</accession>
    <name>A0A6G0W6A6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_019013</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000375">
        <property type="protein sequence ID" value="KAF0721641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W6A6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003204"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="360"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="560"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0721641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="793" mass="90497" checksum="F09858A9834E82E5" modified="2020-08-12" version="1">MDKCCVCGEDEGPDLRQCCMCISKFHHMCIIEEGKKRGWAEAEEGREVCIHCQASDIRVPEVVPPPARKRGRPKGSKNKAKAQDTKDASTPVKRGRPSNSQLRSGDDASEATAIFTPDHKSIRSETMYRCVSFKPLREAQIHKNDKKLLDFYADCQDFMLSGVVTEVRYVVGSENDPDFDTPGKKSKATTKTMVALYKITWNHTRFQREEPWITARLFYKGVEQFATLKANQRMNAGRSYLQISSFVPDEELHEMTEWNMKFLTDSSFDEENKDDEETKNDMQPVDDGSDDEWSEYVERGWKKHGNYDTTEDIEGLEDVEWICGGHYAGPTHLYEHEDNKDDTPVDELRISDEFKDLFKDPVKGFLAFMPLEFWKTVTLRTNAKALALQAAHPKGYVGGREFKKSFELVEVMKFIGLLIMMSVVQGGEYSLYWSKPSMSFLMPPTENFGRVMAIDRFKQLRACITFNDVVEPADPLWRIRPLINLLKASFKNFVVAGREISVDEACIPCRSSYARALIVYNPKKPLGKYHFRIYTAACATTWYVFAFKIHSKAAGNFDAEADDDADDDGEPAPDDDTAKPRDEVKPSALRQHVIDITKQWEGSHRVINLDNWYSSVQLCLTLLKMGLYCRGTVRSNRAHNPRFGMFDKKQIKSVMRGSSLVSVATSLGIIAVSWLDGTVVNMLSTADATTKSFVHRRIGSQTIQQECLSLVGLYNKYMQGVDRHDQLRERFSIASGASFKQWYKKLGFALIDIAITNLYVLYTICEPVNRRDSHLHFQTKLANQMLFETDWTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W701</accession>
    <name>A0A6G0W701_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_018846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000361">
        <property type="protein sequence ID" value="KAF0721859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W701"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015435"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019152">
        <property type="entry name" value="DUF2046"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15276:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15276">
        <property type="entry name" value="H4 D10S170 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09755">
        <property type="entry name" value="DUF2046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0721859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="114" mass="13337" checksum="C69948171C67F5C8" modified="2020-08-12" version="1">MDLAAELALEREKNQRLEAEVDRLRKAVVAASLAAEKEEEYIINQFIRRQQKKLAAIQQQTMAPTPPRRDYEAEMKRLRDEKVALGVRFEQEQESMVNRLVRQFKSSKLVRPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W729</accession>
    <name>A0A6G0W729_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_017918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000317">
        <property type="protein sequence ID" value="KAF0723047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W729"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017255"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052980">
        <property type="entry name" value="Crinkler_effector"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33129:SF1">
        <property type="entry name" value="ATP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33129">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0723047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="317" mass="36654" checksum="82B9A1B63F14853D" modified="2020-08-12" version="1">MIACMPRRIVLVGNAGIGKSYLQLVILLWWARPQLRPDGSLDKFFDKIAVIARVERDNRTDLFFKRDQLHYKMNHLGRLPDLSDLDFKAALLLYEPYLSKNEIHPCGILDGRVWATVPPSPTRYHEFSKTDCAVKYMDCANEEELVFMAAVQKQGMDYNSPLKELYNSAFVRERIRTFGPFQRVVLPTSIDALAIETKNKADELDNLTLEKAFKARKIAESSSADGLTISHHILRISPTMNDEFRTYTLKPASDHVMEKLRYLVLKTDALELKRLLAIYNQSSTNVARQSIPKLLEEFFVWRDNRTDVSQCKHLEKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W859</accession>
    <name>A0A6G0W859_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_017780</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000312">
        <property type="protein sequence ID" value="KAF0723261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W859"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012370"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
        <property type="entry name" value="FYVE_like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="5">
        <location>
            <begin position="265"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0723261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="382" mass="43454" checksum="FF1ABD49CD8F9A74" modified="2020-08-12" version="1">MPGKRPLPLDFFNNPRLSRDTIKRYVDLGKQSAETLIHKAKLRGGAYDWKLHKDESELKIYKQANGGAGPPRYCGVMQVVGTLDEYIDLYRYDTTKQAREYYRRFGGSYVDVALLHTVLPRHPDRPNDSTHIKWCMFKGPLDGLVARRDFVVLETDFEFKVDGKRAWVRSCRSIELAGFPDTRKSLHCLRGSMHDMGQVVVESDRPGYLDMTHVADMELQGAVPSWAIELTFKSWLRSMAEIDRFMRENRLSRSPSLGSSQLTPLDSRSACALCRHKFGLLRKKSNCFKCGDVVCRACNRTWNVKIHGDEFQLQACLSCSLTSTDVVAPWTPHDDSPQPTKTPVEFPLILTMIPERMLLKEEDAVDDDDVVVAVDYSQGIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W932</accession>
    <name>A0A6G0W932_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BD-FAE-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_017478</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000297">
        <property type="protein sequence ID" value="KAF0723703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W932"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014585"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049492">
        <property type="entry name" value="BD-FAE-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002168">
        <property type="entry name" value="Lipase_GDXG_HIS_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF33">
        <property type="entry name" value="KYNURENINE FORMAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20434">
        <property type="entry name" value="BD-FAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01173">
        <property type="entry name" value="LIPASE_GDXG_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BD-FAE-like" evidence="3">
        <location>
            <begin position="168"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0723703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="446" mass="50148" checksum="9B69C2C5814F5959" modified="2020-08-12" version="1">MTSMTVSRSNAIYLIYLLCMLRLAQKTQRRSPVLEGMEGFFWQMLTGEYAHLFLLGNTIGLSTTVAKYLKQPSATWTQAGLTSLHLAVVGLLAQAVRSNFTSAQHLQRAMIKYGVVSPPEARKKIGARSWTDWWMLWNPIPCSLSFPGTIQTVTYGWVGERHPHPLRMDIYRHEACGAMPPILLFIHGGGWIFGSKTFIPSVFLHAMGKKGWLFCAMDYRKAPFVTFPDLLIDCKRALAYLRQAGNSRLQADTSKIVVCGESAGAHLASLVALTAHDKSFQPGFETVDCSVLACVDTYGYHDMTDRYGHFGRIDIQKKSRYYVEFVLKSRLFLDRPLFERASPLFWLLHDKATDVPPFLLIHGAYDSVIPMEDSREFYKALKAFRDRHNDRRAVPDIFVPLPDAEHAFNNIRSPRSLAYNDAVGVFLDAVLAASSKSTKGTPVAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W933</accession>
    <name>A0A6G0W933_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WASH complex subunit strumpellin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_017471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the strumpellin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000297">
        <property type="protein sequence ID" value="KAF0723696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W933"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013245"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071203">
        <property type="term" value="C:WASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140285">
        <property type="term" value="P:endosome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051125">
        <property type="term" value="P:regulation of actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019393">
        <property type="entry name" value="WASH_strumpellin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15691">
        <property type="entry name" value="WASH COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15691:SF6">
        <property type="entry name" value="WASH COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10266">
        <property type="entry name" value="Strumpellin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0723696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1153" mass="132287" checksum="61FD7BF0F560A89C" modified="2020-08-12" version="1">MELGFLAEENDCGQSLLRLVSRGSAIIAELLRLSNNIPGVFLGSAFVEDPEQKKYLDILFDFAYLKNPEEFENRVNSDTDLLDIDDEFMGNHEDILDRFYQLFDSIYKYIHDFLAFCDQLEKGFFIQHNLANILLDTDGAQLMCEALYLYGVMLLLLDQRIPGPARERMVIAFFRNKGESALENIDEVCKLCRVTGYLPGMPKPAQYPERFFKRFAPPEEVVSMVIGKLQTDDVYLQEPAFPHRDHRSTRLAPQASVLYVVLYFAPDILIHEKATMREIVDRHFNDNFIITTYMGNVADLSLEWAPYPSARTALANTLEVSNIVDIVKAKMKASSKSIETLSHFLTEGVLTEQYVLENIDKLLDCIRAANVTIRWTILHSRMQEEIPMMNNSREQRIVFDKGTDPDRLVTLLLQASQLEWKLKQMFELLLASKEERWQHCMKETSDRLSELSEYFTGEKPLTRVERNDDLVKWFADTAAKVNSLDYVDHVKAGRRIKRLIEALGHVEQFDQIDTSLQVKAFLSECRAYLTEMVRTVRVRQEVMGIIETVSDLSYAWEVINDFMSILHTRVKKDPSCVILLRALFLKLASILDVPLTRIYQCNSTDVISVAEYYSGEIVDYVRRVMEIIPQSVFRILAGIIKLQTDHMKVIPVKIEANYLKNHAQLNERYRLARATNEVSKYTEGILAMKKTLLGILEVDPRQVLEEGLRKELVYRVSRAYHDILQFPQAEATTPKECTAIFQNLASTLQAYRLSFEYIQDYVGIYGLRMWHEELSRVINYNVEAECNRYLKKKVYDRTSQYQSRAIPIPRFSPPKDDTSINFMGRLMHALFLMTDPHETVYSFQCLTWFNEEGVEVAGLSTFGVLHQSISLLGLVGVDRMLSFRIVHTLNNLIKFWGTTITPYLPLLDQLTTAVEPTWKIPENASRLYEVALKSVEKVMSKLLKAVLIIGQAALLRKAIASELAFSSKLDAHLLSCSVGTLDKSMMNDIRSHYRSSESAPHPPAPVLVELNKYLETMGSNDPYSKIFITMNEPLEKLSALFLLFVLAYMPKLQYDDQFGALKRVGKNPVDGAPLVLGLSTIFKQFHPSFTEQFVSYLGQYVRSRISESKDNQLPPEVLNVLIFLQQFARVTHMKPSILHSHVPAYVFDAMSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WA45</accession>
    <name>A0A6G0WA45_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_017939</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000317">
        <property type="protein sequence ID" value="KAF0723068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WA45"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011086"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0723068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="283" mass="31205" checksum="9517951E9312B1A8" modified="2020-08-12" version="1">MASVLKVALNLSNVKFPTVKDSFRAQISVSDDDLSTARIWLESKQSKGQWECIVKDIKEHLPKGATYVLPNSVVISSLQCGLSLLDQDKKKEVDIVGCNVGLKECRKGRMEMRLTLTAFGSLEAYYFFDLFPLSVEKVDVLEAKIRDLEEVSEGKPSTPVYLSLSSTQPMNAGGFVVWDTTEATNGLPYELTGDKTEIKIRQAGLHHVQVTAPIQSWNTSYDGFHLLVDGSRVINAQVTSNGTHYCGSISYMLICKPETKIKVQAGATYGLRSGSKVSIFLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WAD0</accession>
    <name>A0A6G0WAD0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_017099</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000278">
        <property type="protein sequence ID" value="KAF0724201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WAD0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017069"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="26"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0724201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="442" mass="51323" checksum="EDED6C046FB0271F" modified="2020-08-12" version="1">MCPDCNKAKGGRPTKQGPIQRMPVYDLKGPFDLMVVDALGPLPTTENGNKYILVFGDYFTRWIEAFPVPHLKTSTFARTLIDEVLCRFVVPNSLLSVRGSNFISELAESMYATLGIHKLSSAPYHPQSQGLVERFNHTIIQMLTIFVNDHHTDWDTYLPRLLFAYRTSHQETLGDSPYFCQFGRDPTLPLDLTFLNSGSTWKSDDLPQYKRRLASSWKQPRTLVERQLVVGQNKSAHSRTDRKPIEFEEQSSVWLYKYFSKSSDPSDNRSRKLATHWHGPYRVHRRLGPNTYQLEVPTHPDRLITVNVDRLKPFRGYYSRPYNDDVHNDDTDLDDLTLDCLPRSSFVEQILFPDKDVAYTNSGSPIYRVVDKRRAARTREADYLVEHVDGSKYWNPLSKLSEYRTYIGDYESQLRMDRGLPPLRRSPRFRDLDLEPLNDTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WAE9</accession>
    <name>A0A6G0WAE9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_017054</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000277">
        <property type="protein sequence ID" value="KAF0724205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WAE9"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0724205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="94" mass="10415" checksum="D6DF9EE5D097A5F8" modified="2020-08-12" version="1">MGRNIVHQKQDTTIFGFESAFKSMQPILEDSGRHPALLGAVILDFPMKIGSSFSDPSALAPRPNVMRLLSFLKPEFAIADMDFFGNARENSLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WAS7</accession>
    <name>A0A6G0WAS7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_016994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000273">
        <property type="protein sequence ID" value="KAF0724332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WAS7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021472"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0724332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="136" mass="15601" checksum="AEF86F4470696EE7" modified="2020-08-12" version="1">MRPKSPKSECGSYATTNSASLSQLSKDERADVESNRPPNACIDEGCMWTRYMLDVCTQHLDHTVGVCDEMLKTSKKPHDKLIALKTSTQTLRRLLDTNPFLWYDRAASSGHRYDERRQPHVCTVLSDEEEERAHFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WBN5</accession>
    <name>A0A6G0WBN5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Ae201684_017215</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000287">
        <property type="protein sequence ID" value="KAF0724015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WBN5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003605"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18965">
        <property type="entry name" value="chromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="10" id="KW-0229">DNA integration</keyword>
    <keyword evidence="14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="17">
        <location>
            <begin position="749"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="16">
        <location>
            <begin position="1064"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1114"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1114"/>
            <end position="1127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF0724015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1133" mass="130630" checksum="B9E27CE6CA9F2FC7" modified="2020-08-12" version="1">MTREVKETICFDFFTFKDTVMLEWDLKDKQFDVILGQPWFRQHSPMIDWRDQEVFALNGDPPPSQSKDSEIGWIMKICEVEPQITPRPPEIELLLDESKDVFPAQLPDGLPPERSVQFELTLKPGAKPQNRPPFRLAKVEQESLDKFVDDLKKKGWVELSTSDWVSNIFGVPKKDENGKMPSRSVWLKTATANTPIRWVLDYRHVNSQSEIPKIPLPNIEDLFNKMYGCGIFSKIDLASGYHQMLVVPQARKYTAFRTHKEILQWCVAPMGMAGMPGIWSRLMRSLFDKFPFVVVYLDDICVYSKSLLDHVSHLRVVLEVLRKEKLYARLDKCAFGVNKVGFLGHTISAEGLQVDRKKVRAIEKWPAPTNRKELLSFLGMAGYYRKFIANYAKLVFPISELAKDSVPWQCTHQQDKAFMTIKAALQQPFVITTDASGYCCGAVLSQQDDDGNDRPIAFLSKKLRETECNWPALEKELYAIKLALTKWRAYVYGSHFDVFTDNSTCQWFLKTPVLTAKLTRWLDFFSSFDFTLHHRPGKTNVVADALSRPPRSHVHVTTCTLHHCDSTCFERYQNVLKWTSNIESISHLDARLLLLMLDTSFEGEDLSIAQLDVEVPQHLVVNHTEEVSYSMVKMDDSMKQRFIRAYAKSKEFEDSAKFVMKDGLYFVKTKDQVWKLCVPNDDYLKVDIISQSHDANTAAHPGVRRTQLYVSQWYFWNGLDDDVKLYVATCETCARYKSSSSKANGRMIPIKSPEECWHTVSVDWITGLPVSNGKDAIMTCVDKTSKRPKYCATTSNVDAPQAAREFFDAVVRHHGLPSVIISDRDPKFTSQFWQSLMKVMGIKHSMTTADRAQSDGATERQNRTLEDALCCQVSYLGHDWTEHLETIEYAHQGLVQTSTGLTPFEVDTGRKLRNPVLNGLESLNEYAKNFSERRQEMIKMALENMENVQDRQKNCYDRRRSSVEFKLGDLVMLATRNIPLKHAQLADKNEKSKLVPRYIGPFEIVEVINLNAMRLKLPHNMNRLHDVFNVDRLKHHVANSSRFSGRPIPKVTPHILDDEGDELFMVEALLKKRQFNRKTEYLVKWHGLPEHEATWEREKNIKHVSHFKRLVQDLREKQGKRSTREQGENVVMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WBV0</accession>
    <name>A0A6G0WBV0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_016658</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000265">
        <property type="protein sequence ID" value="KAF0724727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WBV0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008592"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0724727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="110" mass="12236" checksum="2E6EE0DF7899E2AC" modified="2020-08-12" version="1">MVPNGPVLADPEVGDPNESCPHENVNQMAFRALPLVVVKDRALPVVKVANMVCPNLRMMIVVKAENSLAIEWRARKTNHGHRVPQDSFSTYIQDNEILFAMTADSPQFVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WC62</accession>
    <name>A0A6G0WC62_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_017291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000292">
        <property type="protein sequence ID" value="KAF0723911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WC62"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016073"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0723911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="145" mass="16307" checksum="CFB5643654C2B359" modified="2020-08-12" version="1">MHVQSARMKLHVHRDGVHRLATITSPTRRTTLVCPNRRRSTSSCKPLWAWQEQPQGLSSTPETSLQEDDLLAQDDDSDRDSIGDDGYDNEPQDAAWSSLPRIEPRKNSITLKKNPAASFKSCPDQLGSSFGLTLYKSPLNLKYKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WCV6</accession>
    <name>A0A6G0WCV6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NodB homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_016363</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000250">
        <property type="protein sequence ID" value="KAF0725132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WCV6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019625"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004099">
        <property type="term" value="F:chitin deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="CBM1" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="4">
        <location>
            <begin position="96"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="26"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0725132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="33821" checksum="2113E60AE232BB5E" modified="2020-08-12" version="1">MGYSGPTTCAAGSTCVQYSAYYSQCTPSASAPSASPSSSPSTNAPSSPPSVPSTSPSTAKPTTAPTTSSPPATTSGGPPPITNNGVSSYNWCGKRKWIALMFDDWWPSPAIDDILADLKANNMKASFFLAPGLSSPDPNICTKIKNVLAAGHSVNAHSYTHQHFTHFTAAERATEMKKTEDVVYTQCGLPAGTMKQFRPPYGDLNKEIALEVNKDGYTVISWTYDPVDWDASNNKLSTVWPKSQQLFSQLPSGSSAVILHHTWAYTSSGTKGLLANYKNYFAPLGYQFVTVDQCFDACRADGNCKLAGFGPGLYDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WCW7</accession>
    <name>A0A6G0WCW7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cellulose 1,4-beta-cellobiosidase (non-reducing end)</fullName>
            <ecNumber evidence="3">3.2.1.91</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ae201684_016373</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains.</text>
            <dbReference type="EC" id="3.2.1.91"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 7 (cellulase C) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.91" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000250">
        <property type="protein sequence ID" value="KAF0725142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WCW7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003809"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016162">
        <property type="term" value="F:cellulose 1,4-beta-cellobiosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07999">
        <property type="entry name" value="GH7_CBH_EG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.100.10:FF:000001">
        <property type="entry name" value="Glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.100.10">
        <property type="entry name" value="Glycoside hydrolase, family 7, domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001722">
        <property type="entry name" value="Glyco_hydro_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037019">
        <property type="entry name" value="Glyco_hydro_7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753">
        <property type="entry name" value="1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753:SF2">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00840">
        <property type="entry name" value="Glyco_hydro_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00734">
        <property type="entry name" value="GLHYDRLASE7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="CBM1" evidence="13">
        <location>
            <begin position="531"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="474"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="475"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="500"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="512"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF0725142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="570" mass="60682" checksum="67010E4B5F7EBA27" modified="2020-08-12" version="1">MTKSASLDQILILQFALVSPPTRHREHTMKIAATLAYLTAAILVAHGQQVGTNTPEVHPSLPSQTCTKSGGCTTENTKIVLDANWRWTHNVGGSKNCYTGNLWDSSLCPDPATCASNCALDGADYTGTYGITASGQQVSLQLVTYGQYSTNIGSRVYLLQDDNNYKIFKLLNQEFTFDVDVSSLPCGINGALYFVQMDQDGGKSKYPTNKAGAAYGTGYCDAQCPHDIKFINGEANVKNWVPSSGDPNGGSGQYGSCCSEMDIWESNTYGQAYTSHPCTVTTPTRCSSPSECGDEATNNRYDGVCDKDGCDFNPYRLNNHNFYGPGSSFAVDSTKPLTVVTQFITDDNTANGNLVQIKRFYVQNGKAIDNPNINWSGIDPSTRSRKTCATKPRLTLATTTSTKPRGVVLTMSLWVDFAAHVLWLDSTYPTNKSASVPGVGRGSCPTTSGVPADVEAQYPTATVKYGNIRVGDLGSTTAVQPTTPSSSPVTQPPVTQAPVTQPPVTQPPVTQPPATQRPATQAPVTSAPSSGGVGAYGQCGGNNYSGPTSCVSGYVCHAYSEWYSQCIPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WFL9</accession>
    <name>A0A6G0WFL9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cellulose 1,4-beta-cellobiosidase (non-reducing end)</fullName>
            <ecNumber evidence="3">3.2.1.91</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_015480</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains.</text>
            <dbReference type="EC" id="3.2.1.91"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 7 (cellulase C) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.91" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000222">
        <property type="protein sequence ID" value="KAF0726204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WFL9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012731"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016162">
        <property type="term" value="F:cellulose 1,4-beta-cellobiosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07999">
        <property type="entry name" value="GH7_CBH_EG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.100.10:FF:000001">
        <property type="entry name" value="Glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.100.10">
        <property type="entry name" value="Glycoside hydrolase, family 7, domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001722">
        <property type="entry name" value="Glyco_hydro_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037019">
        <property type="entry name" value="Glyco_hydro_7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753">
        <property type="entry name" value="1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753:SF2">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00840">
        <property type="entry name" value="Glyco_hydro_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00734">
        <property type="entry name" value="GLHYDRLASE7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026233654" description="cellulose 1,4-beta-cellobiosidase (non-reducing end)" evidence="11">
        <location>
            <begin position="21"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="450"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0726204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="523" mass="56243" checksum="7F16BFCF0411F337" modified="2020-08-12" version="1">MKVATAIAFLITALVAYSTAQLAGTVSPEVHPSLSSKTCTASGCTTENTKIVLDANWRWTHNASNYNNCFTGTWDAKLCPDPVTCAKNCALEGVDYVGTYGIMASGNQVGLRLITKGLYGDNVGSRIYLLEDDRNYKMYKLLNKEFTFDVDVSQLPCGMNAALYFVQMEKDGGVSKYPTNKAGAAYGTGYCDAQCPHDIKFINGEANVKNWTVSGGGAYGSCCPEMDIWESNSISQAYTSHPCKITGQYRCTNPVECGDTTRYSGVCDKDGCDFNPYRMNNHTFYGPGSKFTVDSTKPVTVVTQFITDDNTANGDLVEVRRFYVQNGKKIDNSVVNWKGIDPLNSLTDKVCSQAKSVFGDFDDHAKKGGLKAMGVALKAGVVLTMSLWTDHTAHCLWLDSTYPVDKNASLPGVGRGSCPITSGVPSEVESKYPNATVTYSNVRVGDLWTTTSVGTPSPTTKRPTPVPTTTKATPTTKATPVPTTKPTTTIKPTTSKPTTVAPTTTKQPTIPPTTSKTTTPFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WGW3</accession>
    <name>A0A6G0WGW3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_015362</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000217">
        <property type="protein sequence ID" value="KAF0726394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WGW3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013108"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013116"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01100">
        <property type="entry name" value="APPLE_Factor_XI_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000177">
        <property type="entry name" value="Apple"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33946">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33946:SF4">
        <property type="entry name" value="COAGULATION FACTOR XI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14295">
        <property type="entry name" value="PAN_4"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00223">
        <property type="entry name" value="APPLE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Apple" evidence="4">
        <location>
            <begin position="283"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="4">
        <location>
            <begin position="363"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="18"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="139"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0726394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="500" mass="51951" checksum="AECE92A7367642B2" modified="2020-08-12" version="1">MQHRRLPQHRPLKPHQPPLLLALPGATPGSTPQSTPSATPVSTPQATPAATPASTPLSTPSSTPGATPGATPGATPGATPGATPGATPGSTPQSTPSATPVSTPQATPAAAPASTPSSTPSSTPGATPGATPHSTVPCSSQPSTTRPVTTTFGPSTTTPRPTTTTRSPTTTPKPRTTTPSPTSTFRPTTTTPRPTTTTRSPTTTSKPTTTTRPPTTTTTPQTTTRSPTTTPCTTTSSPTTTSAPCTTTRAPTTTPKPTKTTTRVPTTTPKSTPKPCTTDSPLCGKPIHDVDYPGNDIAQTSREDPQDCCTDCSNTPGCAAYVWTAWNDGTCFLKSKAGDPVQYEGAVAAKVHNSAPVTPSIECSKTTKDLDFPGNDIDQTNRQNPDDCCADCAKTPGCTAYVWTPWNDGTCFLKSKLDNPTPYKGARASSQKLWKQPQANTDYFGHDIDNLAGSPEDCCAFCRARDDCVGYTHYEGICWLKGKLGQHREKEGATSAARYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WGX3</accession>
    <name>A0A6G0WGX3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_015363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000217">
        <property type="protein sequence ID" value="KAF0726395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WGX3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020253"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="81"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0726395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="187" mass="21680" checksum="DCB454D8EF83415F" modified="2020-08-12" version="1">MESWVEWDNQITLEEIRVKLLLEHNIQASTSTIHRMLDERIFTYKNVHHEPLQMNDPQFKQMRQEYVRRLRAMLGEGKIPIWIDEKNYNLFTACTKARSKRGTRAVNQRGSSQKGKNLHIIGATSTNNFLYCTAFCGAYNGQHANDWLRDMLRQAKAHFGALGDLLVVCDNAPCHSRLGNVLDEEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WH44</accession>
    <name>A0A6G0WH44_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_015261</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000214">
        <property type="protein sequence ID" value="KAF0726493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WH44"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004936"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF91">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PLK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="4"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0726493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="317" mass="36093" checksum="D39918547D0CCF62" modified="2020-08-12" version="1">MQQYKEIKHLANAIYGDVVLCKDNKSGHLVVIKRAIIEHCKAHKPVAQQYRHVIVSEDIYVERKLLRELSQGRGHPHVLRLVADFDTKEAHHFVVEYCSKGDLFDVLYKAPGCRFDLTQAQTYFRQIVSAVAFLHAKGYAHRDLSFENVLVNDKNECKLMDFGLAVDLYTPQTAEVGKPYYMPPEVASRCSSSPPYDPAKVDVWALGIMLFIMLTGNQLFDKAVDRYANFQIFKSSGLRGLVASNKRWAATMPTHVLDLLDKMIRMNPAERMTIDQVASHAFVNLSATTPIDRTKKGDANPMKWLEMRFPRLSFTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WHT2</accession>
    <name>A0A6G0WHT2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WRKY transcription factor 19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_015119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000210">
        <property type="protein sequence ID" value="KAF0726721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WHT2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013051"/>
    <dbReference type="OrthoDB" id="73726at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827:SF1">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0726721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="31287" checksum="9922CA59CCF2EA5B" modified="2020-08-12" version="1">MYLIVTRSISVRHMATTQSDNGGVLKDERPTKRAQLSPPVSPSRLLLELSQNMDLAYICSNNDPNGAAAAAAAAAASAAAIKSAHDSQPRPAAPPMTCFFNDCHKEVQPGSWKCVFHRNRARCLVADCQNQVYARNLCVRHGGKKQCQHEGCTGNARLGNFCSKHGTGSVKKKCTEEGCTKMAHARHKCVRHGGGRKCKMEGCQTHARNGGYCCRHNRQIANDKERRFPTSLLPADASSYAHIRPNIMLKDEVPAASTNGLEILNLTIERYKVGQVNSAERENVYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WHY7</accession>
    <name>A0A6G0WHY7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_014977</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000205">
        <property type="protein sequence ID" value="KAF0726834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WHY7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013594"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0726834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="181" mass="20302" checksum="79D08D156EE51D01" modified="2020-08-12" version="1">MERRKLHGLQAAQDEDIEPPGEYMMNQSMTNATFPEILVPRGSEIPNAVDSYIPPAQKAAMSTLNLTVCLVAIVAVLIAAVVFLALFRQRQRHPHQHYIPHLEAENTKSRYATGMLVLDTLTNRDPAALLMSMDRTREEGEPSIVLETSGHLDFTSDRLMDIWEDHADSDNSDDTESRTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WI41</accession>
    <name>A0A6G0WI41_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_014990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000205">
        <property type="protein sequence ID" value="KAF0726848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WI41"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013288"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0726848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="373" mass="43020" checksum="BF282A8E73CC9986" modified="2020-08-12" version="1">MGKRMDAISPQNLPLPSGKRTVKPPNLTKEEEAEWKREDACYRKQKQRAREKAEREYMLATVSKLEKHVQDLKRRQLIPKVLLDALPFEIKAAVLENRKLVLKGRHLKKRVEELHEVISMLSTWVNSLKAHTLHPGMVETTLLVHPECRKFSHTWLCQRALNMALSASPYPGFVGKVEDNMISWPHLGEDNFGTSLEAIQLHSQYSVMGDYKDVAAVLWETYITSSPQHTLTVIDSIHDDLVYICVEYGPLKSKVLHVGAKFHLEHRMVVTLTTVAYDERFPMGSGESRLHGFSWMILDEMGMGVTLCRQSSLQYTPVNKERPLTLEEIGDLIHYKLGENEPRENVIYKFQDMIETSFIMQRDMLVRARFPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WIF8</accession>
    <name>A0A6G0WIF8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_014860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000203">
        <property type="protein sequence ID" value="KAF0726995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WIF8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013846"/>
    <dbReference type="OrthoDB" id="72988at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0726995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="162" mass="19313" checksum="43EC23162FCF6EDF" modified="2020-08-12" version="1">MGASSTCSSDSHESNSTTSSSSHHDRTVQYRKAYYAKNKEKEIARMKLYYETNKEKFSAYGKEYYERNREKELDRFKAYRAKNLERDLERKKQWYARNREKILAYAKAYDLKNRDKRNAYQRERRRRLKEAAQGATVTKVLDAEVKSPSAMHMDFLLNPVQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WKJ9</accession>
    <name>A0A6G0WKJ9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_014238</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000188">
        <property type="protein sequence ID" value="KAF0727802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WKJ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019120"/>
    <dbReference type="OrthoDB" id="541276at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF91">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PLK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="3"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0727802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="303" mass="34188" checksum="0E2EE9268F01A192" modified="2020-08-12" version="1">MTYTQIRELANAIFGRVLLCMDHTTQQPVAIKCMNIQAYENKKSIEGNISVLEDVAMEKQVMRALSAGHGHPNVLRLLNDFQHAGHDFLVLEYCPQGELFDLVSQHGRLDLNTAQTYFRQVASAVQYMHSLGYAHCDLSLENVLIDAAGQAKLCDFGLASNLFEWKTGGVGKSFYMAPEMYVQQFYAPGVADVWSLGVMLFIMITGSPLVQKANVSDNAFQFIQQFGLRAIISAWHCEHLFSIEVMELLERMLDPNPATRMSLDEVMVHDFVFEHIPLPPLDDTFAWIDALSFRSKKNPSWSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WP68</accession>
    <name>A0A6G0WP68_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_013163</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000167">
        <property type="protein sequence ID" value="KAF0729186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WP68"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015598"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF37">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="10">
        <location>
            <begin position="626"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="258"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="258"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="290"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0729186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1064" mass="119182" checksum="345291B53E5C8848" modified="2020-08-12" version="1">MSPKRTQPPPVDAANWNPYGSFGAPKSAPTAGTPSCGAAGGAMDEDVGIEDEAMDDCGMVLNAPALPQPPSFKGSTKAERRTFMREYQKYALQVDAMRAAGQRPFLMPVSACIEYFTKRRVAVFDFEKDIQEITEEEWVKWFNEAYEETPVELDVLKKRLQAAIVFDLRITDADSRVSRMLDNLMKALEADGQEWVLHQEAKIVVGLITKAIQPVALQKAVTKQMELSRNKPLKADVVRFVKWLRQYATGYQLYGGMDNDKPAKPADEEMKRGTPRGGKARGKENASGAGEERAEGTKKPAGDAKKPAMTCLKCGSNDHLVRDHPDITETEAKQLIADWHQNRRKAVNAVKAVDKESEAVTSVKYGVTVEGVLALPTVLLDSGSDESLATLGLVKALRNLGVEPEFLSKTACDLKRYGAESKPLRVYRQVRFKTLELNTSFGPLMLRGLTAWVDEGTADCDLLIGRPAMERLGFSVDGLLVEALKQQPVSDMDDVAGPIGAMARVNRLRQLKLEQEPDGDDDETEACATPELSRVRRDDEVQEVLEQKVAEAVEQGLPPGQVDELRRILRAYQDVFRLDFGKDPPVKVAPLKVRLKEGAVPVKVGLRRYPPAHMDYLRQHVAELEAAGLIYRNNRATWAAAPRIVPKKNPGEYRMTIESRPINAWTETMPWPMPNLEAAMATLVGMEVFFTLDWLKGYWQLPLHPECQMWYSFMTPFGVYTPTKILMGQTDAVAFCQSVVNELFGDLMYQGVLGWLDDLLGYARSAEQLLVLLEKVLHICQEYRLKMHPKKCDFYLKEAKWCGKVISSEGISHDPSRVQRLCEMKAPTTAAELQQFLCATNWMRASIPLYAQRVDPLRRLLDVATKIAGSAKKTALAKADLAVARWTAEHDECFEEVKATLARMVPLAHPSEDKAICLFTDASADHWGAACTQVPKEDLELTVDKERHEPLAFLSGSFTGASSRWPVIEKEAYAVVESCKRLEYLLLRQQGFRLFTDHRNLLYIFNPRGYDSGMARYQAHKLQRWAMVMATFPYTLEHVAGEANVWGDLLSRWGAAQQRRPVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WPH4</accession>
    <name>A0A6G0WPH4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="8">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_013004</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="8"/>
    <dbReference type="EMBL" id="VJMJ01000166">
        <property type="protein sequence ID" value="KAF0729254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WPH4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015000"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016971">
        <property type="term" value="F:flavin-dependent sulfhydryl oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1960">
        <property type="entry name" value="QSOX sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042568">
        <property type="entry name" value="QSOX_FAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039798">
        <property type="entry name" value="Sulfhydryl_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22897">
        <property type="entry name" value="QUIESCIN Q6-RELATED SULFHYDRYL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22897:SF8">
        <property type="entry name" value="SULFHYDRYL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04777">
        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="FAD-dependent thiol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 8" id="KW-0274">FAD</keyword>
    <keyword evidence="2 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026245816" description="Sulfhydryl oxidase" evidence="9">
        <location>
            <begin position="17"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="7"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="10">
        <location>
            <begin position="267"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0729254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="433" mass="49158" checksum="3EED1746715BE814" modified="2020-08-12" version="1">MRAWWHVLIGITIVAATAPLFPEDHENVTYLTDDNFDSTVLQSDMSWIVNFYSPSCWHCKVFASSFEEIAAFFKPKIRVGAISCLDHVLCRKLEINGYPHLVFYNFKVHGENRRLGGNVKPSAIYAMVEELENREIPIETTTAPSTTPRPIWTASPETSTHLTRLHDAAVAIIHGFKYEMFAGSESMSPDELAALKQWLDVLAKTFPGAHNRAALKKLLEEVLPLDTLTVDAWHSFVDSWKAKGVSTPRYANETWQKQPQLFDGDGKTFQVCEGYACGLWTLIHLIAHQTNATTDCVEVYGAIRGFVEHFMTCKTCQGHFLQANPRHLQTKTSVALQLWAHRTHNAVNERVRHPQFPSPSDCLRCGTDMSALLRFLDERYGYPEVIDIQVETESHLNSVPWYFIVLGIGSAALWMKCIEKKKRHLVLDKDRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WPJ0</accession>
    <name>A0A6G0WPJ0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_013011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000166">
        <property type="protein sequence ID" value="KAF0729262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WPJ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014993"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0729262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="218" mass="23800" checksum="8544540491766FF0" modified="2020-08-12" version="1">MLLAACEQDRARTCTKSGFSMSHPSFFSVAGTGPAAAPGATPQTSATATPGASPSQNPTHEIFPRPFNGRCKYKSGRCMNERTLKENGQPHTLCEDHRVLHNKNQRKSDTKRRRLRKGMAPFAPTMAQPTEYRSAGSTYSSDPEDARSNEELSDDDSNNATHNTTYDHAMLRPPLPGDLLHYPATAPTTPSASSDTPTVEWSTEEITMLHSLLGIRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WQX5</accession>
    <name>A0A6G0WQX5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_012623</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000160">
        <property type="protein sequence ID" value="KAF0729840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WQX5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014014"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
        <property type="entry name" value="FYVE_like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="5">
        <location>
            <begin position="282"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0729840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="411" mass="47077" checksum="6FE2CAF63B8BD69C" modified="2020-08-12" version="1">MVLSLPLPPNFFKCLPLTPAQIDQYLSQAVDNTHELIDKTIIHGGRVSYKMLSDEKHLKIYKGDYPGAPPNATIHLGYMEVMASLDKVIALFDTEATRPKEFCRRFGKGLLDAVHLYTLDVPTVDAPYKKTTLTWRAYDSQMPKMIMRRDACQIECHNSFTVDGRRGWVRSHKSIRLECCPNLEAVCQLIRSKNHGSGHVFLESERPGYLDMYYVTHVDCSDGPSEWFVDKVMRCRRIVLDAIFKKRCRALLDIDVFLREDRLSRMPYVPPRPNSTALHRKCSLCCKSLPIIRKRQFCEKCGEAFCSRCVNVWDVRVHGRHERVLACYTCSIQTPETRLRTPSLLFARSKTAVSRSTIRSENETRSTSSSTDSKVNSFLVSLGLSRATLARQRLQEDEDDDDDNDSLVLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WRH2</accession>
    <name>A0A6G0WRH2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_012494</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000158">
        <property type="protein sequence ID" value="KAF0730005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WRH2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013768"/>
    <dbReference type="OrthoDB" id="337581at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097196">
        <property type="term" value="C:Shu complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28498">
        <property type="entry name" value="ZINC FINGER SWIM DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28498:SF1">
        <property type="entry name" value="ZINC FINGER SWIM DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="85"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0730005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="146" mass="15622" checksum="6275C4099400C085" modified="2020-08-12" version="1">MSNEMSAAILRQVLGQVKANGGEFTAEHGEILVSVYSNDVELSLLQSASELVEKRRITRVEATPSGRAFYRVASHHAGANGGPSFYICFAHYCSCSGFVETTVLSKTSMCKHILGALLADATGKSIVETIPDDHYADLLCPNVAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WRQ6</accession>
    <name>A0A6G0WRQ6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_012168</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000155">
        <property type="protein sequence ID" value="KAF0730161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WRQ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007674"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000630">
        <property type="entry name" value="ATP-binding cassette (ABC) transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="179"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="141"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0730161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="637" mass="70713" checksum="F116B874D9DA40D9" modified="2020-08-12" version="1">MYRENADIYLFDDPLSALDVHVAGAVFQEYIQNLLADKTVILVLNSHYHFLPKADRVLVMEDGTIVGDGSFDLIKEKFPHLNSFDAAVANDDYVVVVPLPEASSAPASKSGALVENEDRSVGTVASSVYVTYFRSTGWNGVAVIFTIVFAFSLSQATVVMTDWYMGYWAAHPGSNVHSVVFYCVLAFSSMVLLWGRSLFIIYLGILASRTLHSKLFKKVIHAPVNTFFDVTPVGRVLNRFASDLDQVDSILPYFSVLTLQFGFQIAAVLVVCATTSPYILIVYVPLVWLFQRIQAFYSSTSSELKRMETITRTPVINIISETINGLSTIRAFDMTRSFATKSREVLDHNLSFFMIYRVSSRWLQMRLDWLSAFILAGVSFLSVATKSSIGVTAAGLALTYASQMSAFLSRVTMHSATVENIMTCVERLEDYNNLDTEGNSRPESENLPPQWPAQGQIEFESYSMRYRDNLDLVLRDVNFVASGGEKIGICGRTGSGKSTLMVALFRMVESASVCIKIDGLDISKINLKTLRSRLTNIPQDPVLFSGSLRFNIDPSQQASDADLWNVLKKVHLADGLEGGLDFEVAEKGGNLSVGQRQLLCIARALLRQSRVVILDEATANIDLESDRLVQQTIKECF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WRX0</accession>
    <name>A0A6G0WRX0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">histidinol-phosphate transaminase</fullName>
            <ecNumber evidence="4">2.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Imidazole acetol-phosphate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_012231</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23744"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="2.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.9" evidence="4"/>
    <dbReference type="EMBL" id="VJMJ01000155">
        <property type="protein sequence ID" value="KAF0730228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WRX0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002421"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01023">
        <property type="entry name" value="HisC_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01141">
        <property type="entry name" value="hisC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42885:SF2">
        <property type="entry name" value="HISTIDINOL-PHOSPHATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42885">
        <property type="entry name" value="HISTIDINOL-PHOSPHATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="12">
        <location>
            <begin position="87"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0730228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="413" mass="45679" checksum="B5FEE7D1A48FBE46" modified="2020-08-12" version="1">MTKLPVELIATFGVGLGIGVLLHKYALHKSEPLTTTVNNEQDEIRRLIRPNILQLTPYRCARDDYSEGTLLDANENSLGPPLDDDHELKGQNLERYPSPYQVELKNAVATLRQRGDTKLESKHVFLGVGSDEVIDLMIRVACTPRVASILITPPTYGMYSVSADIHDVNIVKSPLVIDHNGDLPSFHIDPEHILATVTPQTKIIFLCSPGNPTANLLRVADIERILTSEFKGFVVVDEAYIDFTDSDESSLAPLVTKYRRLVVTQTLSKGFGLAGIRLGIAFADPTLIQILSNVKAPYNINKLSSKVALDALANVSRLHANVRVILDERKKVIAALQASPYVKTVYATDSNFVLFECDNAFAVYKKMAENGVVIRYRGNQLLLDNCLRATIGSPEENQRMLSMFASVSAEFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WSK3</accession>
    <name>A0A6G0WSK3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_012112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000154">
        <property type="protein sequence ID" value="KAF0730410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WSK3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005612"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF57">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="1">
        <location>
            <begin position="64"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0730410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="294" mass="33283" checksum="F190F7E1DFD5BDE8" modified="2020-08-12" version="1">MSIQQGESVLAEFSARVRKIVDDNDIEDIYNANQTAINYEYIPKKTLDGTGTKTVWIKGSGHEKDRLTAMVLSDAKGTKYPLFLVLKTSKSTVAENVSENLKFRHGFGPIFWPEIEEIQERHPSRFYGNPTGWWNGHISVEFLNYHFGHRHGTESKFVLLLWDDFSAHFTPEVITLAAELRVILEKIPPTYTCICQPADVRLEQPDRFEIVEWINTAWEDLSMSTIVNGFRKCGLIDVTYGSDENMDDNGGEEDDLFAAAGVLESLMQCGAAELIELESELCFDDDDQQQSNTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WSQ9</accession>
    <name>A0A6G0WSQ9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_012164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000154">
        <property type="protein sequence ID" value="KAF0730464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WSQ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015926"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47481">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47481:SF7">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0730464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="277" mass="31825" checksum="7BA37A4471524693" modified="2020-08-12" version="1">MNLMDAATTANDSTMKINKFDGDNFHLWKFKIMMVLGEKDLWDIVSGLENWENQGDAAAQARYTKRQKKAFAVVRLSLENSQLSMVRSCKTAAEAWKRLEDHYEKKSLANKLYLRKNFFSCEMVEGSDMLKYINEMKTLSEQLEAVGAPVGEEDLVITLLCNLPESYEVLITALESRSDALPWEFVTSRMLHEEMKRNEQGSEATKSAAFLTKQEKMMKYPCKICGEFGHCEQGANRRNVQMLRRLPRKQVHGSLWQAKMKRKKKQCGSSTPAQRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WT39</accession>
    <name>A0A6G0WT39_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_012052</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000153">
        <property type="protein sequence ID" value="KAF0730633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WT39"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009665"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026047793" evidence="2">
        <location>
            <begin position="20"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="364"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0730633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="508" mass="50203" checksum="EF429494CC25445E" modified="2020-08-12" version="1">MAVRILLFLLFVGPVAVHGTVECDALSTCGSACYDPAYEGCCGGTVYSHFQAVQDSQYVRQRCCAGVNGAPSFVAATCPQRTATPIATNLIKSKVDLSLLAEPTTTPSALAPPTTTLSALTPPTLLATTTQSPAASPPSAIIPTTTATAAALPSPPTATPAAMAPPPTTTTSSPFPPPTPPTPTTTFAAFPPPMTYTTTASPTRTEATMTTTTPGALPIGFPPTTTSLPATPSAGISPTTTSPPFTPPSLLTTAAPFPGITPVTTVAAAAPPMGVPSRPEPTTTAAALTPPIPTTTPAALTPPSGTTTTPLTPTTTALFPTTTATPLISTTTTKPPTGMSPSTTSAPTLTQLPPAMVGAPISAPTTTTTAAPTTTPVAVGATTSAPTTTTAPTTTATTTPSATTARPTTTAAPTTTPTPTTVAPTTEAPTTTAAPTTEAPTTAAPTTLEPTTEAPTTLEPTTEAPTTTLASPTTTAPLSRPTLPAAASHGQVRSFGCLVALVVVALVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WTA6</accession>
    <name>A0A6G0WTA6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Crossover junction endonuclease MUS81-like HHH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_012091</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000153">
        <property type="protein sequence ID" value="KAF0730672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WTA6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003267"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022312">
        <property type="entry name" value="DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="HHH_MUS81"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276:SF42">
        <property type="entry name" value="DNA POLYMERASE BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276">
        <property type="entry name" value="DNA POLYMERASE TYPE-X FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Crossover junction endonuclease MUS81-like HHH" evidence="3">
        <location>
            <begin position="124"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="64"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; Schiff-base intermediate with DNA; for 5'-dRP lyase activity" evidence="1">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR622312-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0730672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="205" mass="21941" checksum="5C00645849DF1D67" modified="2020-08-12" version="1">MSNKAAAKKAATELLELCKKEGVQVPTDPMNAMIQAGTMLNATRENGEYNIPAALKAMTEKFGAKKVTASPQASKKRKKAGSDEGEDKVKHEKDGDVKDEGKGEGDEEGSAQKKKKVAQATNPKNQDLAEVFADLAGFEFKRGDRFKGGSYSKVAKAIRDTGDVITSGKQATKLKGVGKASAAKIDEFLETGKVEKLEEYRAGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WU84</accession>
    <name>A0A6G0WU84_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_011567</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000147">
        <property type="protein sequence ID" value="KAF0731015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WU84"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017119"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0731015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="386" mass="45268" checksum="1A349F6517A5C639" modified="2020-08-12" version="1">MASTASTSSRTKKASTLTDKDDVDEIKMKKRLYIRKKMQFYRSEEKNEMLALKKKTFELENDVIRLTRPNQFRLRINPVAANIEPEALPWKEVAIALREDRDEKTLQTRSLKHKVDERAFVVECMRRWVDSATAMQHSLNPAAKSWRNVSLLAHPEARAMGKDWITKQLYHNTNDMFRHYGFPNGSNDDNFVMNEILFNEACFDTISARQVIVNMPFEALQKALHGRNMWILMMDNVLGATELDVDSRKPGDLIHHHAMSVIDEHANLLSREFPEEDRCVFVGQQIHEDETVPTQAIQRNRRFWVELQRVGPNQTRMRNIYLISQFFTRRGYLPLPVEARNWGCDLSTTPEHQMEDRFKRHATQLAWRQYNAGLKKLQQSVFSFMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WUK9</accession>
    <name>A0A6G0WUK9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_011449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000146">
        <property type="protein sequence ID" value="KAF0731183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WUK9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005039"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81585">
        <property type="entry name" value="PsbU/PolX domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0731183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="168" mass="18666" checksum="09A51566F88B8239" modified="2020-08-12" version="1">MKAAPELTQEVEPKVMAFALKFINSAPKEKLVVELEIAESIANKVIDQRDFGGYKNLDDIFEKKLMRKKKFTSFRDRLLAYAKDNKPSDKVEDDDTKASNKKGKKKGGASCGGKNDADALLLLQKAEKPVFKESEPLRLRFGYLLAVPQPPAPTVESEIEIAQPISVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WVN8</accession>
    <name>A0A6G0WVN8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_011239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000141">
        <property type="protein sequence ID" value="KAF0731620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WVN8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014851"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0731620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="509" mass="57974" checksum="CDF26E0FC291291B" modified="2020-08-12" version="1">MDDMMEAIHRSKRRIGDASNANNTYNSSSKRMNHCARRRLLAKRERNDVRSLHHVSSHSIAYMETLLNLPQFNNQDVGLIDSDGLSITIEAVDSTHESNVQDVPNECPDDEIEATATAPSSSNFPRLSCRQAWTLWFHGDPQSGLRPLRTLGVADFENDEARRRWWIAKHIMTELTDMALKHDIVPTKEALANLPREDLLSVFESAFAKFTAENKGENQGPFTPDSDCAEALERIFHTRASKQVPKRFVRGDVVPSLPLREMWQLWFHGEGLPHGIPYQRYRSARNKKTQHEASRVMKRLAELAVKEKLVPSIDMLETISSEALLDVFDVIFPVFHRQFEPTAQRVVHPGMLCSTVSGHVAGRAWSKSPEDGENSTQVAMVRVHGDFPSGTAREIWPLWFHGNEASKGVPYRRTVWSGRHDVRRRTRVVLMKMEECAADAVLVGSMEMLEKMPLDELMEIFDDVFDEFVAKYCPACPDSLNKMCTTLYAFMMSHRKAKQNLDVNEQALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WVQ4</accession>
    <name>A0A6G0WVQ4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">Ae201684_011188</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000141">
        <property type="protein sequence ID" value="KAF0731567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010307"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0229">DNA integration</keyword>
    <keyword evidence="16" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="14" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="15" id="KW-0917">Virion maturation</keyword>
    <keyword evidence="18" id="KW-0862">Zinc</keyword>
    <keyword evidence="18" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="21">
        <location>
            <begin position="634"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="22">
        <location>
            <begin position="900"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="287"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="125"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="246"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="318"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="363"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="20">
        <location>
            <begin position="380"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAF0731567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="25">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1615" mass="178079" checksum="4CA27C39B4B35150" modified="2020-08-12" version="1">MDVEMQQGEEPTTRRELISLQARRAAQHSSSTKERESTSLLEIDTSEVVDDARTKRRGSPLPPTAMVAFATSPQTSTVTMIEDDRVSIPSEGTTTPRTSHWRQHDNNRIQEIVRTQLALQSTELFRQLAVSNANAERAIEVAEARAAAAEEEKERQAAVLAKRLHDADVVSQAQRQVLAGATRQYQEMAAQLAQAKVERENALYVATLSTSEVKRLNSEQNEANNRHAMESARQAQHVDFVTASATDAIQRQAEAAAAEVRRLENLSMLQNQELADLRERVHRFETIQQTAGPRDARRVPQHNRGAQDADGPGRIPQRQGTSTAQQPSFVTPAQVDDFDDGENDYFGEMEDDSNDNDSQTRQNGNGNDNPPAGNGAEARGSGGDDGGHGGVHQVNSNSRAPKMKNFKCTPFSGEEVYPGLGHDFESWHVTFQRAVTRDEVFVGSTWEEKHLFHALISCMSKDAERFVTQSETAWLNEAGNRYGYNFVVHKLRQKYASHLSNGELISKMMAPKRWAMSWDEHIVYLRHLQRMSASSDAMVLDMFYKYSCPQHTPSLIACVDLQNKGDPNEMEKALKTLIALTGTGVNFGMNRPNPSQAKPNYQGRANMAHGGRGGGRGGGRGGGNTGRDMTNVTCYKCHKTGHYARSCTSTKQGGAAVAAAEPGNANLAAAPTLPESDEELETGSVWYAGQSDPNGKWLIDSGCSHHMVTSKNILHSPQPSRMDIVTANKVKVESKYKGSVMLHLMEGKKWGLGMARHVPDFDANLVSVTQLTQEGKKVTFEGTTCEISQNGKVLATAKLVGRLWEVDRVPYKWDGDERGDGRPANSTIGSANVAHKSVDTLQGWHERLGHLHKQAIVTMANQRAPSEMTITRIANDLKMPCLGCALGKHTRSEQFKEDTSQSAPSEEIGSVVCMDLKGKIKPRDRLGNQYLAVFVDHASGFTAAVPIKKKSEAERECKTFINALERAHNVVIKVLRSDRGGEFLSAKFKSYLEDKGITHQTTQGSTSASNGKAERMIRTLMDATRTMIFDCDLPPTFWSDAAKHAAYLRNRVPTRSNAGYLSPLEMLTGKAPKVNHLLRFGSDCTVHAPPAHRGIITRGELGRVLGVNPTIKGYDIWVPRLGKVLTTRDVQNVTYTRASTRLSDVPESDLSFNRVQSKTTATKETPTSTKRVHFTRSTAGANASMATMTAEEPRAPRSPVVYDGDEGSYALIATITKDPKTVREALSGPNAAKWTAAMKAEIDSLIANGTWMLVPKPPGTNIVSNKWVFKIKYDSLGAVEKFKARLVARGFSQQYGVDFSETYSPVIKQAAVRFIFIVATLYGGIVEHLDVPQAYVRTNIDTPIHMEVPAMVDGDPETQALLLLKGLYGLKQSGRLWNKDINDTILSLGYQKSKLDACLYFKTIDGKVSLLGLYVDDIFLFVQNAALREQTLGTLKAKYDIESLGRATRCLGTNVHSDEHGHFLEQTSLVDELLAKFNLTNCHGQSTPIAVDHRYDVEGGPSDFTPSQMREIVGTLTWLAANTRPDISYATNMLARHLNDPNEHHARGAKRLLRYLKKTRLYGLELRPTKGLESLEEVFADADRAFDKTTDDRLQEVWSPLAAVPSNGCQSAKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WVS5</accession>
    <name>A0A6G0WVS5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_011235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000141">
        <property type="protein sequence ID" value="KAF0731615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WVS5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014855"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0731615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="594" mass="67497" checksum="59F83A6984789424" modified="2020-08-12" version="1">MKSPKRRVRRASIRFVVSDSDDDDSLKDRRGQDIPDSKHISKGVNTRPTATSSVSIASTAAKILSELPKHRAVVPEGWIYTPCNCTGTWKKWFHGTKREPPLRFIHLDDIDDMASKQRLLKTTILMKELIAATGLPEDVIAEMDNSALLNTFNKAFEKLYPSKDPGGSIVYLSASNNDVDMTALLPSCNELWNKWFTAKPVRWSKLTTEELPFEMQPEHDRHCKFIAKLSQIAVNLGLVESEGAVERLTNVPSKALFVQVFQAFVAQCGPKCRLTPQSSCKEAHAWLDVELDPSFRQDGKPFFPFLSIRTMWCRWYLRHKFLTNGVPYCRPNLWHKDSVDFYTKTKRSIEALVQTAVDHSIVKSNSALEAIKDEDALMKVFDQTLSIFKEQFVDEVKSRVHELMFSYTIVHHLEPSVWMQHPKFGQATSKKAKKPKVLVQPADESTATKPLAPPVVLRPADESTRTKPLAPPVVVRPADESTPCRTMWWLWFRGDERSNFVPFRRTTGQLKAPKAVMKALEELILEESLAPSLDAVEAMDDKTLTRLFEEAFLLFATTFDPSVQSWIQPATMCHVVKKHMTPALWRRHPNAGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WW32</accession>
    <name>A0A6G0WW32_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_011055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000140">
        <property type="protein sequence ID" value="KAF0731753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WW32"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004560"/>
    <dbReference type="OrthoDB" id="74580at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013945">
        <property type="entry name" value="Pkr1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08636">
        <property type="entry name" value="Pkr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0731753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="108" mass="11622" checksum="6712DB165E6AFBC5" modified="2020-08-12" version="1">MIGFLVDKVTMGLLADAIKSALEPGTGDKFVLVLNGVLGTLILVISATIWSGLEDSIHMFVFLFLAVGLTLSINWFIMEARALHAEGKLNLDGGSSKNDARKETKKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WWG2</accession>
    <name>A0A6G0WWG2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_011124</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MPI phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="VJMJ01000140">
        <property type="protein sequence ID" value="KAF0731826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WWG2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010547"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110032">
        <property type="term" value="P:positive regulation of G2/MI transition of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000021">
        <property type="entry name" value="M-phase inducer phosphatase cdc-25.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000751">
        <property type="entry name" value="MPI_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF17">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00716">
        <property type="entry name" value="MPIPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="10">
        <location>
            <begin position="156"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0731826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="302" mass="34037" checksum="ABCC4313FD94A58D" modified="2020-08-12" version="1">MPTITDTSDSTACTPQVTGTGHQTPIFSRTQSDLSGLGSTQRRRFISKSSKRALFTPECVPAKTKRLADEDDSTRPRKQIHRDLMPNDLEACKENIPPPEMHANLNRSLSSPGPLAEVEVYTPLLPVIKSTKHPDLNVLAPSTVKKLINGDFDSVLKGGFHLVDCRFKHEYNGGTLQGAKSLALPQDVEKEFFNPPLKSSSHTALIFFCEFSAKRAPKMARHVRNLDRRLHAEEYPKLHYPELYVIDGGYKHCFESIQDLCEPCAYVPMTHKDHADACKKELSALRASWKRHESSSKRQRWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WXF7</accession>
    <name>A0A6G0WXF7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase C1A papain C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_010814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000137">
        <property type="protein sequence ID" value="KAF0732165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WXF7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007023"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02619">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35899">
        <property type="entry name" value="PAPAIN FAMILY CYSTEINE PROTEASE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35899:SF1">
        <property type="entry name" value="PEPTIDASE C1A PAPAIN C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0732165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="574" mass="64720" checksum="AA2CF729106D2332" modified="2020-08-12" version="1">MADVVRIPLKYGSEDNLQVSPRRRQSHWLWIAGIVFLLTNIIVLISIAIVGKTVSDSFDHVKEIQSQQARQALSVSNIPSKFAVQYVTPRQDQAQRGTCWDFATISLLEWSYRANGVRNGWLRDDEYVAFSEQAYGIEIMRVCTGAENSPQQKACRVAGDFIWNQTTEGGEDYDFYYLQNGLKNSILPTAVCPYSRVGNESLCPGLDDALKTNPVKFNVTSMSTYYDAPTAKLQLFLQNKAMSIGTPVVSVNHYYPCIGPFVNDPHCQKDKETCTLCPSDLSQTTCCVPSKGGRNPNMEGEFFAHNRMSYEGGHAMHVVGYNDAFRNHEGEVGGFILKNSWADSQTRGSHTLKWWLQDISDWEERTICPNSYNPTNWYACGGKDDISDLVSPTNDTTPVSFNNGIQDCLSDTTRLFAKTNVQTLELVCADKTHCKVDPDVTYFVRNTTDWGDRMTLMCVWESNPKVGSARDFCLLPMLEQGLAATFKPKVALPNDPDRCGFYFFSYEAASRYLAQFGQFFIDSYDIEWNPSSYLANADKFPDLDYTLLNRSTFRQNKDDFVGPHPYAKVVDSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WYJ9</accession>
    <name>A0A6G0WYJ9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_010303</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000130">
        <property type="protein sequence ID" value="KAF0732595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WYJ9"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0732595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="83" mass="9329" checksum="CBA8FBFAC70A868C" modified="2020-08-12" version="1">MTYMQRRRGEYPFVQERKMLQVPSATVCCHEFQSQVAIHRVVPGQIQAIPLPELSKAWRLSCNIPVTGLSSNDIQVVLSSVAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WZ12</accession>
    <name>A0A6G0WZ12_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_010269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000129">
        <property type="protein sequence ID" value="KAF0732738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WZ12"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016702"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020141"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0732738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="464" mass="52642" checksum="555D7C62AB9D4182" modified="2020-08-12" version="1">MPVEPSRNEEEQGAVTKVENIIVQRQTVGSRAASVAEEETKAAVEAIAATQQAHQQLTYEQLNSFWDDHQALRRDTSMDFEVQQQRQDELRQQLNDQRRLIDLQQDMLQQAAVAVNQQSEEIGELMETILSPRRRSRWGHFAESGAVDAEMEDEVDTKMPPGVMSGGIVAGGNLPTPPVYKGCTKREKREFMDRYLSFQRRLQALGEGTGRSIALIPIGACVDHNTLISICMFEVKKRADEMTEQDWKNYFLAAKVPNGADYTAIETAIKSLSMDIGTKDGESRVLKLLTDFQDKLGGQDMDTFMFDETKLCIKLSCRAIRPTTLKLSVENDLQKERCKKLRSDITQFVDWLIQRVSAFLTFESSLPKTFHANEEGNKTKNKKAHAAVARAGNSRNQCLKYGARDHGVFKCPDVKPDEAKKLWYEFKKRRQTPKYTGKSSFGRCQFQGKGRGQGGENRFFGWPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WZ46</accession>
    <name>A0A6G0WZ46_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_010129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000128">
        <property type="protein sequence ID" value="KAF0732799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WZ46"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015252"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF214">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0732799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="279" mass="31265" checksum="95228657D4A22696" modified="2020-08-12" version="1">MYKISPSDISIIKPLASGAYGEVLMAQLHGNLVAVKRLTPSKRSNMGDLVKFLDEINLNALIDCPSIVQFIGASWTTPADVVMITELMDHGDLRGFLQSSNQFMFQWPDKVQCAASIAHALIYLHSLDPKVIHRDLKSRNVLLNSSMQFKVTDFGISRQFDDVETMTAGMGTYRWMAPEVLQDGHYAESADVYSFGVILTELSTHLVPYSDLRNDRGNPYTDTAIMAKVMNGDLMPTFAVDCPSWYSKLGERCMAFDANVRPTAMEAFHIIQTELRKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WZI1</accession>
    <name>A0A6G0WZI1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_009858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000126">
        <property type="protein sequence ID" value="KAF0733032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WZI1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001757"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="1">
        <location>
            <begin position="30"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0733032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="82" mass="9054" checksum="2B0E553654BFEFF6" modified="2020-08-12" version="1">MCEIRFDFIEATLHLGSAAASSSRRSFDPSLEYDLAPENPFIGPINQALQAYEWLLRDGHRNIAVMGESAVESPSCPCCNVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X255</accession>
    <name>A0A6G0X255_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_009157</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000118">
        <property type="protein sequence ID" value="KAF0733980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X255"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0733980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="129" mass="14637" checksum="17A71B283CBC0B08" modified="2020-08-12" version="1">MRGTCVLHSQSIAWSFASRSLLHGVLISMFHNISQRQTVEQNTLSNVVSNNLFRVFSSAGSIETFSVRVQEEVLPVPVHAELYRQSLHDRGELRDAPRTRLKQAMLLDGNVTEMQSETERCDHFNALQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X2T0</accession>
    <name>A0A6G0X2T0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_009255</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000118">
        <property type="protein sequence ID" value="KAF0734086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004343"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00173">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45911">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45911:SF4">
        <property type="entry name" value="MULTIPLE C2 AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="4">
        <location>
            <begin position="1587"/>
            <end position="1770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="556"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="563"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="607"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0734086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="2143" mass="243100" checksum="9D61F0DDE43D49A3" modified="2020-08-12" version="1">MPGWRRKRHVVVSLPPVSSPPANNPVEADGHDSEMQSLNTLVHPPTSLEPLPALETHYHTLLTYPRLVHDHTTHLRVGDFVARSAARWASRYERPLDSALARQRVEHSAVIAIQTSARTWLAKRMKSCRVHAVLELQQRRAMWFGRLHAPSAAALALALESPLSSPLLLRIFPITAHLPALSSHRALAACLLQGQLLYRSAVRTARYVRQPQPLKHLIASAVIATSTLLHRLRLQIACHAAVVIQCKHRSRLAIRQRVYLAQVRRRHRAAASIQIAYRSHAAREKLRTLRNHHAALVIQCAFRCYLARQAALRQCRHCVARRHVVDCIRVALPAVAALICNHAARRIQRVQRGRAARSRFRELALQNEALRLKRSPERGFLLYARGAYYEAALLLEQSFLHGVVGDSDFWIKFGTAHFYAFEASGDRSQLEKALMAYRQLFPKADDVERDDKVWLGVALLYAKALFYAHMFRPCLDLTTAFLAWQASRGDKNNLAVAHALAANVLFGMHQLERCKEHLEAMLALGALQIYSELELRYMLAVVLTLLAKEADVDDGSRLKATTEPPPTATTPPPSPKPSDANNPPTAVADPPSSPRLSRENNPKTPTDQPPPPPSPEPRTPQPKLSRAEELQALADAEYAKCFAIVELWPGFGFYHGVMTHAAAEALLEPTPDGTFLLFRIKAASVHVYVKVKWGPNEYTSMKISRDDNSGMYSNPNSMEASDWTLLGFLAKLPKAAGIALRCGLRSGGGDPRLSPSFGVGMTSWDEWKNSNHAWLQAAHEWELHSGYVFASFLASCSPASVEFQHKMRLATKKQSKGWHLAPKTSTLNGVPPPAIQCQVEALIIQAKAARGLGKTMDSLVFIQQAASLDLAADCIRRSWAATSFASDLRKVQKLDRLWVHALGLDTYTPRTHGNPQAEVLLLECIYRQHFHKFATIDVHRRLVRAHIRAYCFCGFDLIHLELACRSTDALVAAWQRQDESVSTPIRPPVMRRLDPSVPKGRKAAKRPRRAKLDVKSWSVELLIEQTEVVYRSLQFNRAIELLQLLLRRTKTHAAAYGHIHRLSALRLAFVYAHTKQFDRAIHTMTQLVHPVEAAPATTGALPRWPVVMAFEFNPMEVRFLRGVLLDMQADSGAPTQEKAWHDFAPLHADMVSHVKKMLQDEQYVANTPDFRAEHVSGVVVTIGECHGLEIDNVMRSNVRIVVQCDGKAVSMTEPPSWETMQPNWNLQKISVPASSKHAHIHITIFNRVQLRDVPLATLQLPLSALFATGHIDGKDFHLRTTSSSGYNATTLFMSFELTTFKPARSRKLQEQRHIAFALSDFVNQAYVWQFFAARFVRMSDHFLARHFLVQALRRLAPPHDIRTIHMMLDVARCDLACRGSNQKLQASAIDWLQKAHHAALMLERRHHSVENEIVDLMQQALQSESSFERKLNMCLEHSLTSDYVVVTSEHGSYFVNKDTGDCILDQPLGFEPSIQKPPLRRTVIFSSSMKPRILAVRQQMKQDAASDPEQWVAMFDEFHGRMFYVSQVHSMQSYKRPERYVMVADEMTVYSVLVIQDVFRARRKRAWLRRLFRRTVHSIMVVNYMLAQWHIREEARAIRAAKVPLTCLKLTIESASELRAADRISSDPFVEIQLSNRTAVRRTTVRKATLEPVWNEVFHLRYAWLDHEQAILHPTPHNAKDEQEEDDEHDHLLSSVDLMRVTGQLAENLVMNEDHGIAKHDNDEGPTIALTVFDYDAPTSAKQEAIRDFLGLAIIPIDPLDHGKPISRELQLRDEDGYLSPRSRGTLSITVQWIPYVFPLQLKTVMVATRAIARLDALKRQRYVERAKLQAPPVLPKPTLSDDHKMLLELIDSKWQDALIKLADAIVMADQLQRLVLRLNEARKSHTNAEEEEHIERRLKAVIRDQFQVKRRGVQDSMRDVAKCLKSFAKVTYDEVNKYVLSGGDVVLQEKVLLWFDNLGYSSETPRVSNDRPIIQDETYDRIMDFVLVQKECFVTWETSLRSLVGECFQEGNWSFDMSKELAICRKIEDTLSDAPLQKPPSTPSDDDKIKHRQVVHAKKLDKQRKHHKANSKVAKVMGSKQKIYAHLYAPGRLRPKLRVFERMDIDTLDGEETACFAFQSCLKFQSKAEKTLRGTPTERLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X4F3</accession>
    <name>A0A6G0X4F3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_008634</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OPI10 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000106">
        <property type="protein sequence ID" value="KAF0734785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X4F3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001497"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001498"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048364">
        <property type="entry name" value="Hikeshi-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008493">
        <property type="entry name" value="Hikeshi-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031318">
        <property type="entry name" value="OPI10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12925">
        <property type="entry name" value="HIKESHI FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12925:SF0">
        <property type="entry name" value="PROTEIN HIKESHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21057">
        <property type="entry name" value="Hikeshi-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05603">
        <property type="entry name" value="Hikeshi-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026039932" description="Peptidase A1 domain-containing protein" evidence="5">
        <location>
            <begin position="19"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="441"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="6">
        <location>
            <begin position="30"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0734785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="729" mass="79518" checksum="554626C1CF072284" modified="2020-08-12" version="1">MRGLAIALPSCALAAVFTEPLYGISTGTSYTIAMRLGANASSTPFQMLLDTGSSNAAVATTTCCSRTRELVGMPMYSCAASPSCVDSAARKVSVNYIASSWSGHVVTDTVILDSLGAIPQVSFVTIDNQTQFFRGGFDGILGVAFDALAQPKGDPVTTLFQTLVNRQNVDDIFSILSCGILQPYVQGIMPAVISGTMILGGIVPSSGIALHRGPLIYSPLIQAKWYVVLVTDIGFNGTSLALDCKVYNTPRAIVDTGTTNLVLPTEVYRAVMAQIQEATLEAIPAFESAYFSDRAVCCDAICDPTNNQSPLLTLPTISISLALEGNTKQQVTVTIPPTYYWRPIVVHSSVGTSTCRMMGISEGTTLILGNVFMDGLMVVHDRKGSRVGVAVADNCPNRAISSKTVSTSQTSLSWCDCLSSGQLNDNLVTALFPGQNICFIWYWWTYVIIVAVSIIAVSCVALVWIWITRRRKKQRQATRAPPTLQESLLYVDEGPMTPKEAPPASDEGEMRPPKFLKWSRIFDIRIIEKFIRMSKFGNRKVFITSKGAATMVAQFGTVIAGRPVVTDYIEISPTQFVVDIPYPEQVTDITFFMLPQSPVPLGYAAVLYFAVPHLQNWQLIGSVFAEKPSAIFRTGWPTHPDVVGQPVVQLGVSIESADNVKNLGIEASGLEERKAFAHKIALDLFNFMSSFSTSTNANMMVIPTNLLDRWMERFEAKYRRDPNFMMKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X5K6</accession>
    <name>A0A6G0X5K6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin-like fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_008408</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000101">
        <property type="protein sequence ID" value="KAF0735199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X5K6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012180"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33875:SF2">
        <property type="entry name" value="ACR183CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33875">
        <property type="entry name" value="OS09G0542200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13462">
        <property type="entry name" value="Thioredoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026020306" description="Thioredoxin-like fold domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin-like fold" evidence="3">
        <location>
            <begin position="31"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0735199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="267" mass="29745" checksum="DBCAB5F5416DBF82" modified="2020-08-12" version="1">MFMYAVLIVLPFVAMAQVPVPPTPPGFTIGHGSASANVQLEVFVDLLCPYSKMAYPALKQLVQHESPDRFRLRVHQFPLPYHHQAFSVAQASETISFALGRETFETWMEAVFEEQDSFGNKVTENQGQKNVTAQIHALAKKTFPNLTDAQWADGMTGHGGTDRDDDTRVAWKYACSRGISGTPMFLLNAVAIDADPAWTYHDWIEFLKPFLDPPSDTNPRHASIQLDAAATFVPGISLLSGLVVVVGCVAVAMSWRFRFRRGYRRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X6B3</accession>
    <name>A0A6G0X6B3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_008021</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000095">
        <property type="protein sequence ID" value="KAF0735541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X6B3"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0735541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="84" mass="8853" checksum="0E1850591EDF260B" modified="2020-08-12" version="1">MTTCITCYKSSGLAGMRPALAVRALARIALACRGSSWLGTLAVSARAWIAGTARRRSLRRALARVAGTRVARAGHVSETVQKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X859</accession>
    <name>A0A6G0X859_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_007190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X859"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020563"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052717">
        <property type="entry name" value="Vacuolar_transposase_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46169">
        <property type="entry name" value="DNA REPLICATION-RELATED ELEMENT FACTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46169:SF15">
        <property type="entry name" value="INNER CENTROMERE PROTEIN A-LIKE ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="261"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0736167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="420" mass="47527" checksum="7E0E88D0A97F4FFE" modified="2020-08-12" version="1">MQELFCLIDQSKKLVEWFKRTNQQSQLDKTLKQENATRWNSLLRCLRSIYDMFDKVVDIKVSNIPQTLLKEFIDFLDVFQQATLALEQFKQPTLHKVIYWRHVLHCHLQPVLADILGTDGNVEKNKDSASIAAIKKILQPILVEKFVVQDLHVQGALLDPKMKNRLLGHGVEPGQVASCKAGLKELMLKYGRSLDLDLFDDSTPPPLKKARQNTSMYDAVSDDDDEEVEAPEWCGNSETQVDLEYKAYMAYKVGEKEFDEIASMHDREFRVLLWWKHKGAMLFPIMALVARSILCVPASSAMSENNFSDAGNTITKKRNPAWSTILCFCGPIETSANEKRLFIFLCAKPMGTASKPVMGMGGQSPATRSVGWAWVPAMNTMQDSASGTIAFRTSLFIVIVIRENVVRLNSNEVSLNLRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X860</accession>
    <name>A0A6G0X860_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_007676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000090">
        <property type="protein sequence ID" value="KAF0736090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X860"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008985"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0736090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="468" mass="53367" checksum="F7F76D63E1EC4388" modified="2020-08-12" version="1">MASEESWLQDLQILIATDDQLQDDLATVCDLFDSDDGFTTRVEESASTSSSSSSSSPIASPQRVADDDKIPKTTSNNTKDCPKEKVKPQRSSVRQREEIRCLRQQIDQLSKVLQTRQTIDLTTIDMPLWKRTAKMGLLEKNKALQENEHLRDAISQQATFIEQMQSVFRKKPRLGTHIDVHSEEWQAYKLAAQASLRQVAIHAIADRQYNRMQSALVKAGVFDRENYLFQVKALPQRDQSYTLEIIHHVDLDAPFRLVGAAAWQVFDGDFQLDLPFGAVQSYTRIDPFTVYATYEHQSSGTAWHSNMIRKYFVEHDREVIVSRTVLEDAAIPHMTKGAIENRCMWLTVKPLPSDANRCRFTLLQHLVWPKDELAFEDADMDIVVGEIKQLCFGFMARRRGRLPMPIWMDISQLPHPKMGAFVERGRRFLRLLQATVNDAIGKFHGEQQIDTQALSSSSDPPLVCNQCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X8I7</accession>
    <name>A0A6G0X8I7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Myosin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_007318</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X8I7"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF845">
        <property type="entry name" value="MYOSIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0518">Myosin</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="7">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="89"/>
            <end position="96"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0736297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="134" mass="15398" checksum="4CAD4233D5EEF716" modified="2020-08-12" version="1">MTSLRHLDEAALVKNLHDRWVDADRKPYTRISNILIAVNPLRYSDKPIDKTPYVHQSLDKSPPHPFHIAENAFRQMRSLKQNQSIIISGESGSGKTETSKIILDFLTERSGLVKVDDKCVRFPRLCEVQFRLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X9M6</accession>
    <name>A0A6G0X9M6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CFA20 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_007102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000088">
        <property type="protein sequence ID" value="KAF0736652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X9M6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016959"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040441">
        <property type="entry name" value="CFA20/CFAP20DC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007714">
        <property type="entry name" value="CFA20_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12458">
        <property type="entry name" value="ORF PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05018">
        <property type="entry name" value="CFA20_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CFA20" evidence="1">
        <location>
            <begin position="57"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0736652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="201" mass="22395" checksum="12F4F88A0F467B0D" modified="2020-08-12" version="1">MKPMAPAPTLTIGEAEDDKLIEPLLPSPNDGTGDLAHHPAVTLAQNECHHVGGDNVVQVVEDADVHQEVVELRGGDARLVFSTQNVMRYLVLFIKNLNAFVTIEVEILDDTKTYREFHITNSRSLARVAASSCQMPLAFGKGDSWRYVCLDLHRMCSEAFGTHHVATVQVRIHATCRLLRAYFQEIEYSDAELPPLLALFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XBS4</accession>
    <name>A0A6G0XBS4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycoside hydrolase family 5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_006696</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XBS4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015542"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901136">
        <property type="term" value="P:carbohydrate derivative catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041036">
        <property type="entry name" value="GH5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052066">
        <property type="entry name" value="Glycosphingolipid_Hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308:SF5">
        <property type="entry name" value="ERGOSTERYL-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18564">
        <property type="entry name" value="Glyco_hydro_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="5">
        <location>
            <begin position="66"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5 C-terminal" evidence="6">
        <location>
            <begin position="548"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0737540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="641" mass="72849" checksum="71E689A1E22F9B6F" modified="2020-08-12" version="1">MTAKCPDAPPLGAFHLELRDGHFYDLDGNVVLLKGVNLGGSSKIPYETKPGSISFVNRPFPLEDADEHYSRLQRWGFNCLRFIVTWEAIEHKGPGIYDQDYLRYLRQVLLIARKYGMYIYIDPHQDAWSRWTGGDGAPLWTLVDLGLNPANFAVTKAALCQDTYGGRPDDFPKMIWPTNFFKFGCATMATLFWAGNKLAPGILMHGEPVQDFLQSHYTNAMVQVANIVADMDHVMGFGTMNEPCVGYIGVQDTKKHFTDTELKLGYAPTPHQGMCLANGIDKTVEVWSSGAKQYVFGRYDHREKVRVKGKRAWQDGVQCIWEMLGLYRFCTKKKKAFALKRNYFAHVDFGVDCYVPFATKYMAAIRKVKPDAILFVEMPPLEFLTTPFPKIKIPRIVNATHWYDAATLFFRTWTAWFNVDSHSRKPVFGKNRVRACHIRALASIKAKAKTFMQNAPTLIGECGIPFNLNSGDSYVTGDFQPQIDAMNNTVSALEANMLSYTLWCYTPDNNNKWGDLWNREDFSLYSMDQAKDKSNRDAGGRGKEGYVRPAAWKINGIPSSSAFDLETCEYALEYLSTDDNKSETIIFVPRTVHYDDGFAIVPSDGEFYVEHFDGYALVHYLHDPRLVMHTIVIKRRIDASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XCE0</accession>
    <name>A0A6G0XCE0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_006348</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000083">
        <property type="protein sequence ID" value="KAF0737683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XCE0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002554"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF91">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PLK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="4"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0737683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="355" mass="39273" checksum="408A38B4E251C7E9" modified="2020-08-12" version="1">MERYTTLKVLAPALYGDVLLCKDNITGDKVAVKRMKLSAARSQTIINDTRKIMEDVVFEKHVNQVLSADGGHQHILRMRADFIENGYEHFVLDYAPNGELFDVVDASDKLSNETALRYFRQILSGVRYMHLRGFAHRDLSLENVLLDEHNNAKVCDFGLAASIPSLRTEGVGKAFYMAPEVVAQLTYDPAKADVWSLGIMLFIMLSGIPLVEMASQADSRFRILKAKGLRRLVQMWKMTSAFEPLALELLERMLDPNAETRITLDQVLAHPYVHDPAVEAATAMLASIKVSSNAKLSRTTSTASTASSTSSTTSPCKVKGLAYTVMDCLRSMSRRPSSRKIVAAPTQSLVSIATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XCM7</accession>
    <name>A0A6G0XCM7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="13">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ae201684_005959</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RAD25/XPB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="13"/>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0737963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XCM7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017944"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000112">
        <property type="term" value="C:nucleotide-excision repair factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18029">
        <property type="entry name" value="DEXHc_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18789">
        <property type="entry name" value="SF2_C_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000077">
        <property type="entry name" value="Probable DNA repair helicase RAD25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000117">
        <property type="entry name" value="Putative DNA repair helicase rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050615">
        <property type="entry name" value="ATP-dep_DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032438">
        <property type="entry name" value="ERCC3_RAD25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001161">
        <property type="entry name" value="XPB/Ssl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032830">
        <property type="entry name" value="XPB/Ssl2_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00603">
        <property type="entry name" value="rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274">
        <property type="entry name" value="RAD25/XP-B DNA REPAIR HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16203">
        <property type="entry name" value="ERCC3_RAD25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13625">
        <property type="entry name" value="Helicase_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00851">
        <property type="entry name" value="XRODRMPGMNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="335"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="553"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF0737963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="797" mass="89853" checksum="5B4679849399CF3C" modified="2020-08-12" version="1">MSTTTRVQKKRSLAEDYVGGVGEDLQAYLDDENDPIQSTDAVSASNKLSQRIQKRLTQLNQSTLESEKGDAQYFDFSSLSMKKDHASRPVWVCPNGRIFLEAFSPLYKQAYDFLVAISEPVSRPEFLHEYKLTPYSLYAAVSVSIETESIIKVLERLSKNHLPACIIQFVKECTSSYGKAKLVLHHNEYYVESLYPKVLKRLLEEEPIRLARVKEDVLNTATASTYNTQGEFLQKEVSAEDQANKQYEQLLMEDYDQTEDQQRAKAAAAATTVQTVSFRIRKTQVEQVKRACLDIDFPLMEEYDFRNDKSIPDIEMDLKPTTRIREYQEKSLSKMFGNGRARSGIIVLPCGAGKTLTGVTAASTIKKSCLCLCTSAVSVEQWTAQFKMWTTIPEKKIARFTSVAKDPIDPVSGVIVTTYTMVAFGGSRAAQSAAVMEIIQSREWGCILLDEVHVVPAKMFRKVIGSIACHCKLGLTATLVREDDLIGDLNFLIGPKLYEANWMDLTQSGFLANVSCVEVWCPMTGPFYAEYLKENVSARKRALLYVANPNKFSAAEYLIKYHEERGDKILLFSDDVFALRLYATKLQKGFIYGGTGERERMRLLQSFRSSPHVNVICISKVGDTSIDLPEANVIIQVSSHFGSRRQEAQRLGRILRPKANATGGFNAFFYTLISTDTHEMFYSNKRQQYLVDQGYTFKVVTELYDKSTFEGVFTSKEAQSELLAEVLEAQDLEKYIDDENAEISKIGGDEDLGRVYGKKKKTTSLGALSGADGSKYMEYSTGHGAKQRHNLFRDRYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XCW9</accession>
    <name>A0A6G0XCW9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_006023</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. The alpha chain contains the catalytic site.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0738031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XCW9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005050"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14132">
        <property type="entry name" value="STKc_CK2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000059">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000088">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045216">
        <property type="entry name" value="CK2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="34"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0738031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="344" mass="40108" checksum="1B766CBBDA09CEFB" modified="2020-08-12" version="1">MSRARVYADVNETRPREYWDYENLSISWGDQDSYEVCRKIGRGKYSEVFEGVNVPNGSKCVIKILKPVKKKKIKREIKILQNLSGGPNIVQLLDVVRDPQSKTPSLVTEYVNNADFRTLYPTFTDFDVRYYMYELLKALDFCHSNGIMHRDVKPHNILIDHEKRQLRLIDFGLAEFYHPNREYNVRVATRCYKGPELLVDMQEYDYSLDMWSLGCVLAAIIFKKDPFFHGQDNYDQLVKIVKVKGTEELFDYLTTYDLELDPQFDGILGTHSKKPWEKFITAENKHLVSPEALDFLDGLLKFDHQERLTAKEAMAHPFFQPIRDFHLNEDKHPDVTSSSSDASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XCZ0</accession>
    <name>A0A6G0XCZ0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4440 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_006017</name>
        <name evidence="2" type="ORF">Ae201684_006018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0738025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0738026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XCZ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009902"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009783">
        <property type="entry name" value="DUF1348"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31757">
        <property type="entry name" value="SLL0781 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31757:SF0">
        <property type="entry name" value="SLL0781 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07080">
        <property type="entry name" value="DUF1348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0738025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0738026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="179" mass="20799" checksum="7E3ABB3C5BA29DEB" modified="2020-08-12" version="1">MTRASWKSLAHLNALSKSAKSTLYTAETAKGPLQDFAANVETPRAPFPPFTRETALQKVKAAEDAWNSRDAARVSLAYTQDTVWRNRDEIFVGRDAVVEFLTRKWVGETNYKLVKNLWCYDGNRIAVRFTYEYQRVSDGQWFRCHGNELWQFDEQGYMQHRDMSGNDIPIDEKDRLYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XE22</accession>
    <name>A0A6G0XE22_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_005711</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000074">
        <property type="protein sequence ID" value="KAF0738482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XE22"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001513"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
        <property type="entry name" value="FYVE_like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="START" evidence="6">
        <location>
            <begin position="141"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="5">
        <location>
            <begin position="267"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0738482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="399" mass="44922" checksum="D3A333E00F39A5E4" modified="2020-08-12" version="1">MKPPTPHKTPPRTLSPDECDAFLALGKEACLGLIENALALAALPVHSKIQNPATASHATVHHGWDIHEPNLAAYCATSTMEASIADLCDFFQLDSLDHTNAYATTASPHLKSRQHLFTVQDCREFTGLSASIVWCAQRVMPLVASRDFCFLEYQTAVDIQDDVRGHRKGWIRCLHSVDIADCPPLPGYHRARLSRSGYLVLETETPGLVEVLSVVVPDYGARLPSWIVAMLVQRQLAHALKIEEFMAKERLVPWLEDTDTTDIVRLSEFTQSCARCDQPFSWRRRRRQCRICFKTICKACGTQWKVPSGPLHASNTMFVCTHCLCPKDSLPRASRTTMMLSCSDTQRDRLRQLAKTLDGLTPRRQLQSQEMAQLIQTTNELVHLVHDLRESIDSGYFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XFD5</accession>
    <name>A0A6G0XFD5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_005180</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000067">
        <property type="protein sequence ID" value="KAF0738990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XFD5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000493"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057494">
        <property type="entry name" value="Rossman_Mical"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25413">
        <property type="entry name" value="Rossman_Mical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="19"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="55"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="111"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="346"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="535"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="195"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="356"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0738990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1048" mass="116927" checksum="6D112450326B3A3F" modified="2020-08-12" version="1">MDWLEGCRPSHNEIFRGDMADDNLNKLFVHLDQNQDGLLCPEDLSKQVRGLGFAKAWQLIAEMDRSGDGYVPQSEFQKTMKQLVHENYDSEEDALSWIGIYKSFFNIPMKSSKSSPPPKSAPAQISTLPPPAPRSSFSGTSDRPTNMAEARARRRSAREYEPPKETSTKTKPTIFASMRQLLRPVPATELPRSLSADDAKASESKKPRVVSSTRQETPVSSRSSRHSSSRLEQFLQSVPPNQMRHSSSSTSLKDDDERSNLAGQTANEEPFESPKPPARNDHRQFPQRASSSLSDAPSLGISLDDPEMDLFGRSSLDYRISDPEEGLFGPSSTIVQAQGIATQDFTHDNMDANPPSTAPPKEFPPAPLSQANSFQTLKSDITDCLKAIQAAVVQLTAVDEENARVIYASLLDIKTKLTVRNLPPVLGAALKSFDKSSLAVVDDSEKQYNSVSIQHVEQAMKIRAFRKNVLAQVFPQVPDHPLSVLGDLFPDILPDTIEQMFDACAQDLQSCFQVLVGLSDYSALDSKLSPKQSYLRKQPDKKMSFDGFEEEDEEDLDAPLFDIKGYVKPEKNERVVSKPRDSKPHGQYFALLPFNESDNPVPTTIPPRRDDIVQWYSDFESGQNMPEIMSAWARFHLDPSLHHSQVYPQLKKLLLPYLSFRQGRIFEILDKKRQGHALYTQQVAASKRVCIVGGGPVGLRCAIEIALLGGHVIVLEKRGEFTRENILHLYPWVVHDLTALGAKIFYRQFCMSSSHLHIGTRQLQCILLKTALMLGVSVFTHTSFDAFVKAEDGYSIQTSPPLPLEFQRVSALIGAGGSRDTIGNMVGIDRKAFSPSPAVGAVVIFPNTNTKEELAIKQFSWASQYNQELFGRLRDDLGVDVENIVYYRDEVHYIVMTPKKASLVKAGVLQDGKELTSWNSDALHRYVKCVLDFFKIPFPTTGVDAQLFDFSQTLRAVKAAVVLPHPTSKLFVALVGDALLEPFWPQGLGINRGFLSVLDTAFAITRLDKADDFKILIEHDKHYRCCTSLMLQANIGKFNVDPASRYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XFL5</accession>
    <name>A0A6G0XFL5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_005443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000070">
        <property type="protein sequence ID" value="KAF0738832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XFL5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016813"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0738832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="275" mass="30834" checksum="D70CB7788FE07F52" modified="2020-08-12" version="1">MKRKRSGDEDDKEEEELRDASMLPNRIPGGGWRDIPRNTKLTDVETLTFFSEFKRAGDLTDKDVIDRCNFLMRHAPPHSYRKLKIKSKFVQLIQRLEKVDLREHCLGRDDCLQPSGVVWKTGEEIETAGRDCFPDDVMFCTIAKDLFKLWPLLSFMQGIGTLHQVDGRAIELGRKIMHLLDELGKKYPALAKLLDPPTVIFNLQAMSIKPAAVVIPAGLAPGNVPAFPGAVGIWTCPSELRAGELIGHLRATLAPVLLPGVVPQFHYFIAPMQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XFY9</accession>
    <name>A0A6G0XFY9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="13">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ae201684_005203</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56008"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56028"/>
            <dbReference type="Rhea" id="RHEA-COMP:14358"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60628"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="13"/>
    <dbReference type="EMBL" id="VJMJ01000067">
        <property type="protein sequence ID" value="KAF0739015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XFY9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006187"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF55">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MANNOSYL-OLIGOSACCHARIDE 1,2-ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="395"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="423"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="512"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="352"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF0739015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="527" mass="59460" checksum="F2E8E6CA85CB0758" modified="2020-08-12" version="1">MARSRYVWILAIGATCCFLNVLYLASKNGMLENLIPKNPLLRRIGFNKATSRAFNGTLNAMPMMPSLKNDTAMQQRVVEAMSWAWKAYRTHAFGYDSLNVEKMIKDGLAGHDMAITLVDAMDTLHVMGLYGDFNEAADWAEANLSARFPWPRQVSIFETTIRNLGGLLSSYSLSGRPGLLAVADDLGARLVRGLNKTALPFSLVNLIDGSTSDISFVAEFTTIQLEFKYLAKVTGKWEYYTAVEKLMDKVAAIVERDYPDGILPVIVDSNNGRINRGVIKLGAGGDSYYEYLLKQWLLSGKTETKYRDMYLVAVEGIMTKLVGRTKKSNWLFLGEYDPSSNHLWPKMDHLVCFIPGMLALGYANGMPESHFELAQELVHTCFQMYNQMGSKLSPEIAYFNVDDENAPDIQVHAADAFNILRPETVESLMIMYRVTGNETYREWGRLIFDAFERNARVAKGGYASVGNVDAARATQFFRPTMDSFFLAETLKYFFLLYSDEDTIPLYKYVFNTEAHPLPIQREGFKPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XFZ0</accession>
    <name>A0A6G0XFZ0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_005212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000067">
        <property type="protein sequence ID" value="KAF0739024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XFZ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013386"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="54"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0739024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="93" mass="10403" checksum="5F1D567D6094B874" modified="2020-08-12" version="1">MADQDGQVDMAKAQSTMDETWSAIDKSNQGYLGHDEAKLFIETTLHELGIPGDLTEESLTTILEELDNDGSGHFSKSQMIDFFSNFMCFFTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XG73</accession>
    <name>A0A6G0XG73_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_005073</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000065">
        <property type="protein sequence ID" value="KAF0739297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XG73"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017316"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0739297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="596" mass="66433" checksum="7231E5BE0E916923" modified="2020-08-12" version="1">MDTPIKTPALPEDVVTAVPVVVHADNEKGGKGSPVQAVLIDNLPRLEVDFLVKKAKAIGSDDWVWRQIVLHGQKLEVIHKNTVVETFSTVACELNEAMSATKVYQIVSGGKTRLTFCCPSETLYNKFATVFRASRMTEFWTFPPVDVFEDFVGVAKMIVESEAGLKASPVKAPAVPASNVTVAQVQAHLASLKAAYDAFPHFGSQEELYQHVLAVEADFVKALDAKQADNYPPIVRQILKLYPEAVGEDGSYTGLTLQLDFTKCPHCFKPFSLKTRINLHVGGKTLVCDQCDNWTHYETFKLAQLRREMPTFDFKSSILKAARSMPMPDIPRDGKIKSYTDRLSRVIYEYEATKYSVPTKAKFALEDRVMACVNRLDLVQLIYRQLLIMSQIVVHFDYWNHPTVVQAAIYRYDKFRVLATPPKALALAATLDILLVGQTHQLTSTTAVFPIDKGSDALLSRLGNAAFLWGQTFNEPYSSCALEDNEPLEASSRGGFPRDKWEKFTRLPSRGNRFVGVQEVFAVESLGYNPEFAHEGLATAVSVIGALEIDDRISRGKFRSLLPQDVSRVYMHRYIRDLPTLAEKIILGFGLGVAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XHR4</accession>
    <name>A0A6G0XHR4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_004689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000062">
        <property type="protein sequence ID" value="KAF0739803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XHR4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018951"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0739803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="599" mass="67435" checksum="4E1E591171E0F191" modified="2020-08-12" version="1">MNLPWLTCCSKLGYLYSIVSLGFSIVYVFILTEYTTNDHFWRNFNSTGGYTFLADVVNTKLRLGELGEFDIFSQAILKDYSLPKTYTDIRLSATRRALTHSVSFEMAVAAYRANTMFENANTMAPYCWVDFGHQYEMAHTAKRQLRCAKKLFDNAAAHMESLLRNTRLSDLMQSVYGIQINQTILTAVLTLPGGTTWVANLMKLMDDDWGSIPDEVAYWRSQGTTYFAIQYQNRFQTGNLNRIDIINALGITRSMTISIVPYISRSLSLWSTRYVNTGWWNDMSKCISIGANMLRNTSQSIEALGRNWDTIYTGATTTVGGDIVRAYVGPFMTWDTKVLSPPPSLLKMLANFHTQFYDLLRSDISFSSAYQNIFESDIDVVPSNWGGQDMLYYGGNPMCSLITQSKTYVQMPFSFDDACQRQDRLAILFARTATLFSMWISQPQTSSTIATSCNLSLLNAITCNRILTSTMPLISKLTTPDGVSSVVQDLQSLNLLFVQLASRNLSKILLTQPIIPNIGDPWSPFGWMTLYDWVDGTREAYAFEGDVGSLSLMSARSANLPVASNPLELPRTACVYFRYAVLILSIGSISKRWTQLFSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XIB6</accession>
    <name>A0A6G0XIB6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_004433</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000055">
        <property type="protein sequence ID" value="KAF0739986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XIB6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021232"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000007">
        <property type="entry name" value="Lysosomal beta glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051915">
        <property type="entry name" value="Cellulose_Degrad_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30620:SF16">
        <property type="entry name" value="LYSOSOMAL BETA GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30620">
        <property type="entry name" value="PERIPLASMIC BETA-GLUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="PKD" evidence="7">
        <location>
            <begin position="679"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0739986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="815" mass="89482" checksum="5625B6ED2E1090FD" modified="2020-08-12" version="1">MSGYEPIDPPTPGTAPSRRRYLPVGVGAIFLGLCALSVLDQIPAQNFQAVPQVQTQTQAQPQVQPQDPSAEKAVEAILANLTVAQKVGQMLQVDVGTILRGSRNPHIALNKPVVRRLAKLGIGSYFNSPFDRSSSHELWTASEWKHIIDEINAIYAKENAVPMIYGIDTVHGANYVRGAALFPQPLACASSFNPDLVYRMGEIEAKDSLAAGLAWIFSPIIGIAMHPKWARNYETFGEDPYLVTQLGVAAIRGIQANKRAAASMKHFIAYSNPTSGNDRTDSVVSDFELLNYFSPSFIAAVKEGQVKTAMETYTSVNGEPVLASHKLLDDLLRHDMGFNGLLVSDDDEFHRLVAEHHIAKNDKDAIDMVFNHTSLDMNMVPYKGIQDRITERLVARGELTEARLDESVRRILRLKYDLGLFNKSQTPFVPPTAVGSLEDQKEAKAMADEAIILLKNGPKTPVDAVNPKHVLPIEDPHATVFLTGPLADSKAFLCGGWTIFWQGTRNSSQIAHGISIREGLNRSFANLQYAEGVDTNGRAVEKRSEVLAKAAKSSYTIVVLGEAPYAEKTGDIDNLALPEGQLEYVRQLTAINTTNVIVIVVEGRPRLLNGITNDAAAVLLSFLPCEQGGEAFADILTGRVNPSAKLPITYPKNSGNVHLPYFHRVNTECRDEFAECEMEWTFGSGLSYTSFKYGKITLSQHNVSASGTLTVSVPVTNTGGRAGKETVLLFISQKVRHKYVPERKLLKKFQKISLQPQQTTVVNFTLTAAVWSYYEPQIGQGFKTVVDPGVFHVQIKHDTDCSKATHLCKSFRVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XIH6</accession>
    <name>A0A6G0XIH6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_004487</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000055">
        <property type="protein sequence ID" value="KAF0740046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017668"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="696"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="726"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="783"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="967"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1035"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="106"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="365"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="461"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="501"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1328"/>
            <end position="1392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0740046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1416" mass="159829" checksum="BFD9041E6C8EECFB" modified="2020-08-12" version="1">MGRQLLHWAFEELWDAVEDGLDELVPNDLQAIDSAGNTLFILACCAGEAHIVSLLLARDPQSDQVVNKPNNNGMTGFMYASMEGYTDMTALLLQHATIDVNVTDHDGMSALMLASRHGQAKIVAMLLQDARVNVNLVDKNHCSAFIHACKLGDSDIVETFLEQSNADFNLADKDGWTGFMSACSDGNKDVLTLLRKDSRVDVNAVNHVGMSGFLMVCRNGDFELIRLLLEHAKLHVSQENKDGWTAADFISCKLHCATYQDTRENDKIVDSIGKILRRGGSLKHVMMTVACKGECKGGVLNLSELAHGNKWEDIRNQLRQGYLGDINKTYKGKTLLERCCKEGKLELVALTLHHKGVDVDFLNNKRNSALDVAISRNRVECVKLLLGAGAAIEHDNKSALDKLNEGAKNPRKVLEIRQLVQDEVQKRQEFPLHCLLEYGKLDEFHKALQTVKVPLDRTDQHGKTVLMLAAEGGLVEIVRELLNHKLDIDFQQTDKDTDGFQGKTALAYAALNGHFAVVDVLLSHLTEMEITYLKDIVEYSIFDLVKEQLSSEETTSQYDSSNLTKCLDLLEKEKSYRANSSIYVDKLRSKLQAMADDAPFDEVLFRRSINADPSLGRLFLNDCLHPDRHELGFSKLEVVYGVDDVHTSALYSILHLESDNLEFMNEAKKLLEHVVMQRVLRLKWEFFAQRMFLEQLLIYVVMISSMTISVTMHGELQETESFAHEIAWWAISLVFACLGFVVAQLLRPKPLWCVSRFLHEGNFAFAPGYHIPNLSKVKTRAKWIFSTVVVITTLAVAPVVVLFVLPGVERLLQDEGWGYTLSLKAAINVVLWTTTAYFLILEWKEFRGESGVFSLLPWMAKSTSSSIAASSTSKTPTRKTSWKYFESAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXLSIFAVIQLALSCTFYQLLHDKGQVGYDTPWRAFTTTLFVLFGQYEDMWTKPDDDTLKDSAVIRPFAMMLTLFHATLVTVLLLNVLLATMNRTVDRGLDLSKTEALWSYAQCILRMEVTLTDEQREQVIFIDQSGGGQNVGQRHRTVWRLATDSSVGDDTMPLLPTKPERYNSSFRRRAEVVGILNPAFEEKVAKADMPIGDEDAQVIKGLEETIKEWDTSLEELHTTTLGELDKVRASIKHTNHFTKTPMFTDELEHLSRTKRKIMTIFADAIKKRAPEAMDKAKRIQELDKRIQREMYDLKAQFAKSPDSLSSTTFYHIVHGTKLTDALALCDKTIERRFQAVKDKFAREAMQEPTLNDLRNQLRDTNDARMKAMADKFKEHAAKLHKVEEKIHTAVHDQVAKLQHQVQAMKTEMDAQQAKLQAQMDLIVRLLHQINDYSHAPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XIN8</accession>
    <name>A0A6G0XIN8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">40S ribosomal protein S28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_004455</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000055">
        <property type="protein sequence ID" value="KAF0740010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XIN8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015621"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04457">
        <property type="entry name" value="S1_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000289">
        <property type="entry name" value="Ribosomal_eS28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01200">
        <property type="entry name" value="Ribosomal_S28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0740010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="101" mass="11319" checksum="E08F5F1E9DF75AE7" modified="2020-08-12" version="1">MDQPVKHAKVIRVLGRTGNTGNVTQVRVEFFDDFGGKEARTLIRNVKGPVREGDIFSPLEISCWQVATWSCTCVDHRVNLWTPRVADHDKTHLALASSFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJ62</accession>
    <name>A0A6G0XJ62_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Short chain dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_004224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000053">
        <property type="protein sequence ID" value="KAF0740219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJ62"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016786"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05325">
        <property type="entry name" value="carb_red_sniffer_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052184">
        <property type="entry name" value="SDR_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458:SF1">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0740219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="25076" checksum="64A1D79F4C7661B8" modified="2020-08-12" version="1">MSSPKRVLITGASRGIGLTFAKHYKSHGWNVIAAVRDPANAKELIDLQLEKIVRLDVANEESILEAAATVGPNVPIDLLINNAGILANDNLETATRASILQHFEVNALGPWLVTRAFLPSLEIAAKSASSGPTIVAQVTSQMGSIERNTTGKYYAYRSSKSALNSLTKSLSVDLKPHGITCILLHPGYVQTDMTAHNGEITTEESVAGLTTILSNATADDNGRFYHTNGTILPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XK84</accession>
    <name>A0A6G0XK84_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_004012</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000048">
        <property type="protein sequence ID" value="KAF0740637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009213"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1159"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1545"/>
            <end position="1570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="412"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="881"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0740637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1681" mass="180354" checksum="056C566E2E4D0AA9" modified="2020-08-12" version="1">MTGADAAVDDKPQSSADGDGDCRSTPPPLSKATKAAWKRTLKQLKLKDVGKKVEAIHYCATDSRFFREGGAIALLMALLTRAKQHEVLSQALVMFSRLVASESDPADSVANALFILEEGLNPATPWNGAEYFLAIVSMAVDDSMKTTAMAIFTKLVEACYALPPSHPNRSELVASVISRGEPIAQCSLAIASPNIALQYSGLNAVVVFSTGHPDPRDVVSRLECLDKIVAFVLHDDARFSHVALQLVEFVSRFGTSSMTATMLDVRAVDVGQTSSVHANAPATLTTKLQMLVAAAAPADSADIPESVFDAMELTARILTRLHVNMPSEDDNLLLAGVSHLVAALATASIKQKIRAATASVLLSCLGRLMERFERCKTHVKQLAIMTTLVHYLVMDETTNLTPRAVVAADATDNKGKAAKGGGGKPGKDKKESPAKETASVPPTPASPDVPGDLDPTLADAMAKDAALAAEKAAAIFLQVRHAAEKILHLCAIVDSSGAVDARIFGASVDGDPWMQYDVFQTIFGAADPSTILRGVRFMALAAQHSNNCGRIGIAGAQSLVGILSDQTKQQLFQDGVRRELDAAARQSYAALVAYIADALSKVSAGSQEICELCGDEALSPVTALVDFVVENSTAGTMDVVNPLNHTWGCPDATIVELAFPKLTYKPQVLAAETLAILARTVLDFAAARGDDPSTPPLTDRGRGKDKKAKEAMVLVGERVAQQIAKYSLKLLDLLATLSDLDLHAAVLLILESIPYLPNGRKTLLRQAQEQIVADRSPPHTDATAAINAMDVIPPEGLAVGEWPYRSPIPDMLQAHARLLQPVLHVFHRPDSLLRDIVIALRLLRSLFVDDKAPQDEYSLDVFANVAVCTGVVVVLTSLLDVVRLQDDLSRDVNQVEELQALVRQLLQHLARLGRLRESTVVPKLEAFIADEEDTSDSAKSIASRWIELLSAPHDFARFGYIGHSALLVAIDIGDTEVANLLMETGVSAATAVDSSGNSSLTKALSTGSQDMISCVLHGGANVEAMNLHDDSVLKFCLISTDSIRSSSVESAMTTLRHAKNAAASDVFAAALVTDSLIRETSPMELLQMCLERGSDPNVSDADGSFPLHWVLSKTHVRTHVRGCRVCLSFDSTRLGSADVVALAKLLLDHHANVNVANKLGQTPLHVAVLNGHGAAARVLLDHGAHPFMVDQYGCLPLHYLCGGSCGDATMPLIDAMLGVSTKFQLTASEHVDLRKGKTRAEKTLVDLDAILDAGLASVIAPKTLTTRPSSPLALLTHTSSSGLFPFHYACGAKEPQLDFAETNIDTAPTRLAVLQHLVKAYRVDLGQPTTHRLNALHFAAKFDRDGSNGALLGFLLEQQCPLDAVHDPKPISVPRMLPPMTRVRYHGEDGHEIASISTVSSAGSYDIITQASGQLVSDVPRSALTCVASKDDGLALAAEFAFAPVHYAVLHSDNATWQLLHAGAAVIPEGSDVPLLALSCAAQRSLDVIEYLAPRLASQANVRVELTEELSGTALHFAVSLGNIDVARILLDSAQATIKVKRPSDGYTPMHIACERGMKEMVLFLAARNAFNECSGGNDTSPLLLLVAKRHKQILEALMEVKLLSDSQMEDVAAFVHERAQIDGGNEWDEWSQWIKSVFPLQEEPQEPNQDDVHDTEERMKCREEEEALPTHAIEPEVFIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XKQ7</accession>
    <name>A0A6G0XKQ7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_003863</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. MFSD6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000045">
        <property type="protein sequence ID" value="KAF0740731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XKQ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019039"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024989">
        <property type="entry name" value="MFS_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051717">
        <property type="entry name" value="MFS_MFSD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172:SF41">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12832">
        <property type="entry name" value="MFS_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="207"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0740731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="405" mass="44668" checksum="4D881C21C90F1FC3" modified="2020-08-12" version="1">MAIDQLWPAKAMYTVSYFGFATVLSYLPVFFNAYFDKLQIGILSAIPCVCSIVAPPLWGALADILNQQRWVHIFCIVSGTLLMFLTEFSVSSFWFTCFVVFLANFQANPTFSLLDQAVMALLENVGGEYGKQRLFGAIGWGFGSFITGLVVNTYGINWTFNLHLIFCLPNLYFLNMIPAANPKDGSSPSAQNLSFFEGLALIAKKVDIMLLFFVIFLIGLMFGVVSSFLTLNLYELSDKSTTIVGTAIWVETLSELPAFYVADAVANYLGIVKVLLISIIGYGIRITYYAVMVNAWSALPFELLHGLTFSLAWSACTKYMYDATPPGTEGTMMGLLNAVLNGLGRGAGTLMGGYLYENYDARFMWYATDLGVPLALVGLFLFSRSMDKHAAQKVDSMSPVEIKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XKX3</accession>
    <name>A0A6G0XKX3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_003640</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the exocyst complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SEC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000041">
        <property type="protein sequence ID" value="KAF0741068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XKX3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005638"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029175">
        <property type="entry name" value="EXOC2/Sec5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039481">
        <property type="entry name" value="EXOC2/Sec5_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13043:SF1">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13043">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT SEC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15469">
        <property type="entry name" value="Sec5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component EXOC2/Sec5 N-terminal" evidence="5">
        <location>
            <begin position="15"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF15469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0741068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="712" mass="79549" checksum="4A2D615FBFE2A1C5" modified="2020-08-12" version="1">MDDDEFMAERLDPRLDMNSTEFNAKDYLASKHATTSYSALLQELQTLKRSTSDKTEQLKLLVASHFDEYLSCHEAIREVAEEIRVHESESELLTTAYQKLKSNTDATLSMMLKRCEEQRKIQHAMAVLNRFRSMFEVPARLRDHLKKKQYLKLVEEYLQLKTNVAKANLNALLKPVFDAAHQTTLQANAELVQQIESTTLSLATHNEAIQALELLGFVAKPALVCVRHQLSAAEKLLSQCIVSPPPDSAAAKTAKIKLKASASTVNAPVVTKTPAEIIQICASIVGTFSRGLWSLVCDTMKSATLTAAEQESVHASVHSILSETIKHFETHSLALGTTPDFVATMHPLFVQFDALQPCPDSVLNSKIQGLKQRFCIQLRLNLLLAFLVAQQQSMEHSWLVYVDNHRQEWTNALQELATQPLLTALTKKPTVLRAAATAWSDMLAAWWKDVQPRIAAAVETNTSATEEAHRSVFCAAIYDGLNVAGQVLVTAFCDGLVPLFADSSPAFGPLAGLTNALHALQTVRPWLAQWFPTKKHVDEVLHPLEAMKDQCFNQYMTPRLGQLDAALQSEETFALTVGDSSGDNDSTAADSHTDDSRHYIFAVLLLLVTWRHEIERCVDEAWRAKYVSTMLRQCVGKIVQFLESRLQAETTAPTWCLVHLQVELAFVCSHLRQWIPLESAHLKRIDGKRGDVQALLSQLELQTQMYRLCLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XL14</accession>
    <name>A0A6G0XL14_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Lysosomal Pro-X carboxypeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_003826</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000042">
        <property type="protein sequence ID" value="KAF0740942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XL14"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016201"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.980">
        <property type="entry name" value="Serine carboxypeptidase S28, SKS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042269">
        <property type="entry name" value="Ser_carbopepase_S28_SKS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF38">
        <property type="entry name" value="LYSOSOMAL PRO-X CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0740942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="516" mass="57281" checksum="EF83D33F87E4C51D" modified="2020-08-12" version="1">MLESSPLLVGRRREKTKLRISYTDKAAIIIGVVAALCVGAIYYVARTTVHDVAMINMRANTNLDFSGDLRDRCSEHYMEQPLNHFKAIPDSYRQRYFICDEFWTSPTGPIFFYFGHDDDVELYLNHTGLMWENAPEFGAMLVFAEHRFFGKSMPRNAVSHLEHLSSKQVLADHAALINHIKRSNDGTTASPVIGFGGSYGAMLGIWFHTIYLEVMAGLVAAAAPLVRFLGGDPLGNSTALVYNVSRTVIMTETCASNIQRAWNLVLEAAKSPEEMERLQSQLGLCEPLASAGDVNALVEWIQTSYNSLTSGSLPSMSLSIVSRLKALAETPLQEARAPLASPFPLTTAGNSSLLGALRESIDAIYNSTADKSCYSVATSPQDDIRDCLFCLESNPLQDLARMRSSPQLPVFQRQNCATKWKLSSPSSTSHYKSWNAVRSLTNLVLSYNPSDPWTNSEMLQGLSDSTIVIEIHDDARNLDLMFSSILDSESVKAARIEERKHMKRWIQPARPSINPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XLQ6</accession>
    <name>A0A6G0XLQ6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine aminopeptidase S33 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_003493</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000037">
        <property type="protein sequence ID" value="KAF0741384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XLQ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010576"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052920">
        <property type="entry name" value="DNA-binding_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43358">
        <property type="entry name" value="ALPHA/BETA-HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43358:SF4">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0741384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="660" mass="73182" checksum="022724EEC7FEBE8C" modified="2020-08-12" version="1">MGAGASFEVFAPGELEHEMKAVDATSPSTSWELFKAGYDSIVHTIIRPPRHDYSVDSALGPSEFELAGQAFRRRDFTVLNERGQALQCSIWDTEPGRSSCVLYLHGISGSRVESTSLLGSILQMGSAFAAFDFSGSGKSDGSYISMGYTEHHDDWVVLQALHKYRGGQFEAVNMYGRSMGANAALLVLQEGLVRNQTSTATVRVQDFGFSAQAICGGEETLVLTSTANNKIDFIPGDALIRVGDCDVRGKSSTFVLNLLSDCPAQESLTLSGLRRAANGTAPLFVQWLVLDSSFIDLETVLRDMVTTAQSDGWQIPSFVVSAGIALLRSTIKRTAGFDLQAVSPGVGLEKCNIPAVFVHATQDVFVPLRHRQVSLSQAYGGKKEIVTFKGTHDSLRSRDLTEAILTKAHKMHLASTKDEEAFRRELFPTGIEYPSLVWSNASKWKNSEDGNSSQSISPYSAFATGYRMVETADSRHVAYMIHVYAPPHLFMKQPSDAPNCFGEKDKESALRVEVSVDEREIKSFWKSFSTATKSSKWNWLRWGKHKQTSSWRNLATDMDTEVPTHQNVVEHRESIEPTFQVERRCHDFKLLLTKLSALPSGLPNDLQVIRSKLVYSTKMGVFRLEERKELLNTALQVISSTPALWSHSIVHEFLRLEKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XLX1</accession>
    <name>A0A6G0XLX1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_003545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000039">
        <property type="protein sequence ID" value="KAF0741211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XLX1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007239"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0741211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="255" mass="28571" checksum="F8DCA8C2460DB56E" modified="2020-08-12" version="1">MLSAWYQLVDGQKGAAYNGTTVAKVTISSVSNVYDFRDAVYAKNLRKLSAYYANDLLVFTNIHVNTLITLEDPIQKYGGSPENALVVRVPSRESGVQLSYLNGMNRSAPHLARTELVEHVFEKMQSSRQRFFHFVSPRASGKTSLLQLYADRYPHVNCIYISFLVPDQWAVELLLSCRIDVDGETASLDPNQDHVVMVDDAQAKYDETGFWPKLVKVASMWLPDNIRFIICATHALEGGVASPVEFQSLLHVLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XN11</accession>
    <name>A0A6G0XN11_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_003305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000036">
        <property type="protein sequence ID" value="KAF0741627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XN11"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011099"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.110.10:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 4-phosphate 5-kinase 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43215">
        <property type="entry name" value="RADIAL SPOKE HEAD 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43215:SF14">
        <property type="entry name" value="RADIAL SPOKE HEAD 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0741627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="360" mass="40898" checksum="9A22C2546BA58F45" modified="2020-08-12" version="1">MEYSGQMSDGLMHGQGMLVYPNKEKYTGEFVRGKRHGIGVMQFEDGSVYTGMWQNDVIHGAGARQYPNGNKYEGDWVNGVINGKGRLHYYDGDFYEGYWKDGKMDAHGVYQFHNGDRYEGEWKEDQRHGRGTIVYKGGDGHIHEKYEGEWCRGQMHGKGTYWYGDGSLYEGEWQHDQMHGKGTYVYHNGNKYTGEWFHDLKQGYGVMEYTNGEKYDGLWQEDLFHGMGTFRDILGHQYTGQWVAGLKQGKGQLVMKNRDVFVGEWGSDGTTAGGVLTYANGDKYEGQLVGYARQGTGTFYCKVDGKSYHGEWLNNKKHGTGSLRFPTGEVLRGEWKEGVLVPGTLVFQLAPASPWNEPTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XN54</accession>
    <name>A0A6G0XN54_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_003053</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000034">
        <property type="protein sequence ID" value="KAF0741862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XN54"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000953"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF33">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026348588" description="Thioredoxin domain-containing protein" evidence="4">
        <location>
            <begin position="19"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="15"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0741862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="857" mass="93502" checksum="4E409F7ADEB91617" modified="2020-08-12" version="1">MRVHAFAAIAGGLSVATATQAPQLDPKALESHRVVAPDEAQFKALLEEKDVVFAKFYAPWCGHCKALSPTWKELSATFSVLENVQVVHVDCDIHTTLCASQNIEGYPTLKIFHGGQFEEYEGPRSLGALTDYLVQRIDAPVHNFGTLSSPPHAINAILVVSVTFVLGLLVSIYLLCFRPTNRVNPPKFYSLPDNSTIKKGHGAVYKVGSFPKPTVSLLEKLEATVKSNGDGAFLGRRPIDSDGKAGPYVWETYAQAYTRIKNLSSGLQAEKMLEPLPDGHRILSIYMRNRPEYLIAMYAAFYAGGLFCALYDTLGASSTAFILTQTQITTVVTTSNELKTIIKAKSQSPSLKFVVLADVTVATQADIDACKAVGLKLSTTADIEAVGAKNPRAPIYPKVNDMAFLMYTSGTTGDPKGVEISHSNILACVAGAEDRLKKYKGVQVFSTKGIHLSYLPLPHILEQIVCAVMISHGARIGFYQGHTLKLAEDLVALRPTHFVTVPRLLNKIYDTIVNSAKASGGIKSWLFDLAMRTKLANLKKDYRSHPFFDWLVFSKIQARLGLDRCNFVLTGSAPLSDDVMSFFRIMLDAFISEGYGQSECTAASNLTDFDDVECGTVGAPMISAEIKLVSVPEMGYEVTDTVHGDKTPIPVNGRGEICYRGPTVFAGYYKAPDKTAEALDADGWLHSGDIGVWTLDGRLKIIDRKKNIFKLSQGEYVAPEKIENIIAASEYVAQSFVYGDSLHAVLVGIIVPEAPTLKKLAASLNITGTLDELCENPKIIEAVHKDIVAVGKSGLLSGFETVRAIHLHLEHFSVENNLLTPTFKLKRNEAKKLFAKQIDDLYVRAGDLVAGKNVKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XNH5</accession>
    <name>A0A6G0XNH5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="6 7">6.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_003054</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="6 7"/>
    <dbReference type="EMBL" id="VJMJ01000034">
        <property type="protein sequence ID" value="KAF0741863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XNH5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000954"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05927">
        <property type="entry name" value="LC-FACS_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045311">
        <property type="entry name" value="LC-FACS_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF33">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="9">
        <location>
            <begin position="73"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU369030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0741863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="711" mass="77635" checksum="19EA5C457874D809" modified="2020-08-12" version="1">MLTSFTPAVLIAAIVVLGLAVVIYVLFFKPTNYIAMPKSFSQADPSTIKPGHGAAHRVGSFPKSPVDTLYQLFERAVKKNPDGNFLGHRPLDAQGNAGPYVWETYAQVHARIQHLASGIIHENIVPPNKSGERMLCIYMKNRPEWVLVQYTMWYLGGCISSLYDSLGATSTAFILNQTESPAVICTSSEFLQVVKTKPLVSTLKHVIVVDIADKSQEELDAATSVGLKLWTLFELEAIGAKHLAPPLPARNSDTSILMYTSGTTGDPKGVKITHNNILVCIMGIEGRLNRGKSSGLFQPNATHLSYLPLPHIFEQLVHAIMISNAAGIGFFQGDTRKLMEDLKTLRPTVFSTVPRLLNRMYDKVIQGGKSKGGLSAWLFDIALKTKLANLKAGYLSHPLYDRLIFKNIQRQLGLDKCSVVISGSAPLSEDVMSFFRVILDCPVFEGYGQSECTGAVTITDVNDLTVGTVGAPLACAEIKLISVPEMGYEVTDTTHGDNPSARIPVNGRGEICYRGPSIFPGYYNAPDKTAEALDEEGWLHSGDIGVWTLDGRLKVVDRKKNIFKLSQGEYVAPEKIENVIKASEYVAQPFVYGDSLHSLLVAIIVPNEKKLLELGETLGVAGSFAELCEDAKVVDAVLKDITAAAKAGKLHGFEIPRAIFLTPEPFTIENDMLTPTFKLKRNDAKKKFQAHIDDLYVKSGDAVAGKQVKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XPF3</accession>
    <name>A0A6G0XPF3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_002866</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000030">
        <property type="protein sequence ID" value="KAF0742201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XPF3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053331">
        <property type="entry name" value="EGF-like_comC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013111">
        <property type="entry name" value="EGF_extracell"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24032">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07974">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026263977" description="EGF-like domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="356"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0742201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="374" mass="39688" checksum="6AF2347449FE89C2" modified="2020-08-12" version="1">MARLVKGLLVVACALVAVDAACPNKCSGHGTCGANDICTCEQNWINADCSGRQCPFTRAWQDTANYNNDAHYFIECGGRGVCDRTTGICQCDEAFTGSGCRRLRCPNDCSGHGECMFIEDLAVSPDKRVNGNAAFTTYTGWDREKIQGCKCDPGWEGFGCNQRVCPKGDDPLTTGQYDMYQAIKITHAAAIKFIIKYADPYGNLWTTSEIAAADPAADAATCANIQTALQRIPNMALSSRILNSNQITVTTGDINPYTRSTSTMGTAIADAAGATQCIIYFPAAPGTTGLQSLLQVDVTDYTTAGSQPYSAGGVTTAVNVYEHIPGTIAAGAYTRPLTELATCSNRGQCNGETGECKCYPGHKGLACELQEALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XQ15</accession>
    <name>A0A6G0XQ15_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VPS9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_002498</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000026">
        <property type="protein sequence ID" value="KAF0742598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XQ15"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014227"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF25">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN AND VPS9 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="2">
        <location>
            <begin position="417"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0742598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="566" mass="62899" checksum="A530F790629C4987" modified="2020-08-12" version="1">MEKQKPLGGKAWLMPNMVSSVFRRVVLHLDGHVLLQKLAFVCQAWRHALLADDELWQAVVAKEFPSTILHPAAQTSWVSVYIGEKTRRFATPSPLRLLPTMDRLAVNLHGQTFDLVLERRESIVLQGDVQWLRKRTFAKHAWHHATMVLGDTAVTLTAKHEAHSIQIHIRDLEVKQERAQVRLIRASFAAIILSVASDDVAAAWTAAVSHNRLALEAKCLAVLHSPVKPTASSLSHLRRFHAFRLTQAIAAANPVRRSSISKDVLLALHGKSPLGMGENVPRLPPDTIPRHPNAKPMRHGTIRRARGALHLVPDPSTIASAIVNDPDTFEGHACAQYINLARTKAPKTPQLCHDQLCKTRDVMANLVDYIMAYRQGDLVRSGGVDSVRGAVYAAVERKICLALAKPIVDWTRKCIPSQAQDKLRRRMQAWSSLPPSSKQFGLLPHLILSWTSVVSRLRAIDAETLPSLKLRHLLDAAKCIFQVFNQSRSDTRDSNALSADDFLPVFIHCLCLSQLKEPLATLEMLWTLCSEESLQGEAGYYLTMMEASLEYIRTAAAVVQDMPGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XQ65</accession>
    <name>A0A6G0XQ65_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Piwi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_002590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000027">
        <property type="protein sequence ID" value="KAF0742495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XQ65"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005148"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04657">
        <property type="entry name" value="Piwi_ago-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032472">
        <property type="entry name" value="ArgoL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032473">
        <property type="entry name" value="Argonaute_Mid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032474">
        <property type="entry name" value="Argonaute_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045246">
        <property type="entry name" value="Piwi_ago-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16488">
        <property type="entry name" value="ArgoL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16487">
        <property type="entry name" value="ArgoMid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16486">
        <property type="entry name" value="ArgoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01163">
        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="2">
        <location>
            <begin position="386"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="3">
        <location>
            <begin position="663"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0742495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="998" mass="109675" checksum="3FFBB39A1C79CFDC" modified="2020-08-12" version="1">MSGRPPNRSRSRSPQRRGYAPSRSPPRRQDDRGGGYDDQRGYGGGGGGRGYGGGGGDRGYGGRDDRGGYDRDDRGGGGYGRGGGGYGGRDDRGGGGGYGGRDDRGGGGGYGGRDDRGGGGGRFGGGGGGGRFGGGRDGGRGFGGRGGGGNFSIPSGPPPEPVKSQLLAPQVDTLFPCRPAFGSHGQPIVVWTNYYQVDLKPGQGDIYHYDVVFCPHGATPTQSLPVKELCLKVLGLLIAKLKEEFPTSTVVSDGRRNIYTPTQLPFDNRVYVISEVFESGKSKEWDVHVKAADPVAIPMSQVEQFFSGQLNFTPYEAIMALDIALRASANIRFTAVGRNFFSPANKASLGEGAELWYGYHQSLRPTQTRLALNIDVAATAFIEQMSLPDYIQKVMGDRINWSDPGFIKQAARILKSVKVRVTHRPIKKEFKITGLSSSAAKDTFFTKEDGSQMSISEYFALTYQALRHPEWPCAQIGKKSKPQFLPLEVCETIGGQKVTRKETPNQVANIIKYTCTKPEERRRKIEDQIANAHFEADNCLEAFGATINPKMLAVQARQLPDPELVYARNSIERPRDGTWNLRGKGFFEGKELLSFAILNLGNPRDDRPIEDFFRALVQQLDAVNMQGPRGPRPPLLTRNRQSVEELFQEAIYAAEQTFGSRPRVIFAVNGVGDSVAYMDLKRASDVTFGIPSQCMLAKHIQKKSPQYIANLLLKVNMKLGGRNSICRADLPKVSECPTIIFGCDVTHPGPGNKSQPSIASCVATMDKYASHHAACVRKQGSRVEYIEDLESMVNELLKRFYQSTHVKPERILIYRDGLSDGQFHNVLTKEVAAIRAACEKLDPDYKPPITYVVVQKRHHTRIFPTQAHECDRSGNCKAGTVVDTGICHPTEYDFFLMSHSGLQGTSRPGHYHVLLDEINFHPDELQTLTYHLCYTFARCTRAVGVVPTIYYAHLVAERARLFVVDSSDGGSTVDGTFVESTGRLMEVHRDLLNVMYYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XQU9</accession>
    <name>A0A6G0XQU9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ae201684_002392</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000025">
        <property type="protein sequence ID" value="KAF0742691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XQU9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003110"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000009">
        <property type="entry name" value="Probable E3 ubiquitin-protein ligase HECTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF440">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NEDD-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="12">
        <location>
            <begin position="59"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="13">
        <location>
            <begin position="226"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="9">
        <location>
            <position position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF0742691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="564" mass="65110" checksum="B6838D377088F917" modified="2020-08-12" version="1">MDSTTVTWVLLSACFTMLILPWFLLRIYWRQSGEALLPNEIVGHLEGLTRDILEDRSLEATKWICGICDFHNATDQSACVLCHTTKGIYLLERREFVAVEGTLRLDQLNIDQWAARNRKQWLREFQDQNWKWLASRPLEKSTTFYSVEASEPNGTMAWLPLADSTAGSTVLGDELPSWWFSLLQELRDLHFSLTYAWLLSYLSYSYNDKRHVTTTRDNIFKESLWALENLKVDQLCSRTKVTLKGEVAVDAGGVSREWYTLLTYAIFEPKRGLFIANKTDQYFFINPNSERDHGRKHLEKFHAIGRLLGRAIVDEQVLPFHFSVPLFKMILGYPISMDDIRYLDPTVHSSLEFVRDSPDVEALTLTFSVSVDATTEVDLIPNGRDVAVTNFNKAEYVERMVRYLLFDSIAPQLQSMIQGLYEVLPPEVLMVFDYKELELVLCGFSEIDVSDWRRCTTVSRSLEMIVDWFWDIVEFEMTSVERERFLQFTTGSSRVPLQGFKGLTSHDGRLCPFSLRGVPYTKGAFPKVHSCFNRIDLPVYPTRELLREGLFALVNIESMAFTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XRE7</accession>
    <name>A0A6G0XRE7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_002294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000023">
        <property type="protein sequence ID" value="KAF0742900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XRE7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006900"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0742900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="377" mass="42656" checksum="FA1AF54112075A96" modified="2020-08-12" version="1">MSFSACPSDAVRGLLSNAFAELAAREEFLEVDIWRRLADEAKVLYDTAKIKERVREHPVTVETVKTCPQLLDFIVDESQTQYDAERNCTMQGILTYTSAAAAAEPEKPIKPPSKRAKQKSQRMQLIYNYERRYAGEQFGTTASYSIHVVFDYGQRKPLVECAFRNSGRYPVSYYERQAVMASGGNDEANEENESEGGLEVKQDDENEEDHGDEADQDDETKDDEASAEDDEETQEDEDGQADEAQENSDDEDGKDEDQEGEDGESGDDEDDDADGHDDGQDDQVDGDEGDDTEAMEVHVLDDDEKNWEYVESFEFAQETFEEVHAWLDERKKVSVQDMLGYIVGMPFFEDEFGIDDRIFDIVFDEDDDGDEGGEETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XRK2</accession>
    <name>A0A6G0XRK2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_002127</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000022">
        <property type="protein sequence ID" value="KAF0743069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XRK2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013342"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006912">
        <property type="entry name" value="Harbinger_derived_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47150:SF5">
        <property type="entry name" value="OS07G0546750 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47150">
        <property type="entry name" value="OS12G0169200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04827">
        <property type="entry name" value="Plant_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0743069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="45559" checksum="28C355C41124DE79" modified="2020-08-12" version="1">MPLSNDRKRKMLYIDDDDDEIIEVLTRTSPMAVTRHFKAPNIDRDFQSDHDRIQRDYFDENVTYPPRLFERRFRMSRSLFVRIMDGVIASDTYFQRRRDATGRLGLSGLQKITCAIQILLETILSCRCRNIWKVLSSVTNFKRLRYASDPERITWLYGNAWEYRLYEMALEECPKELSGQHSDLWIWHAMFGIPGANNAINVVHKSTFVHEILKDTNAKISYTLNGTQRDQPYLLADGIYPPWSIFVKAFQSPSTAKTQHFTRAHEAARKDVERAFGVLQSRFHILAYPSNLWFVNDMSAIMYCCIILHNMIVEERSMCPGSYSYTNEEVIAVSDLRDLPDISVESELVAQNYINTLAMAWSKLEDPQRHQELRDDIVEEMWKVRGNSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XRV5</accession>
    <name>A0A6G0XRV5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Derlin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_002139</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the derlin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000022">
        <property type="protein sequence ID" value="KAF0743081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XRV5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009995"/>
    <dbReference type="OrthoDB" id="1716531at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007599">
        <property type="entry name" value="DER1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11009">
        <property type="entry name" value="DER1-LIKE PROTEIN, DERLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04511">
        <property type="entry name" value="DER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="218"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0743081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="243" mass="27359" checksum="4FA2ABDA8962AAF6" modified="2020-08-12" version="1">MSSPEAWFNNLPQITRFYITACVATTCMTQFGLLSPRTIYLDFELVFFKFNFWRLITCFCFVGKFSFHFLVCLLLLGQYGSVLEKDPFVAGGGPTADFAFMLIIGGSVLAVIGFFLGYPFLGEPMIFMILYVWSRKHPEQMVSFWGFQFKALYFPWAMVGFTLLTGGDPIPELAGVFAGHVFYFFLEILPNTKDIHLLKTPQFLVNLFPSNRPIAPPRQAAPGAAATGPSRYNWGTGRTLGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XS02</accession>
    <name>A0A6G0XS02_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_001843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000017">
        <property type="protein sequence ID" value="KAF0743368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XS02"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000694"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026341140" evidence="1">
        <location>
            <begin position="20"/>
            <end position="959"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0743368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="959" mass="105556" checksum="2145B9894755560E" modified="2020-08-12" version="1">MRWWFLGLLLSLLVCHSHAQSNATVYLVVQWNNIDLNVIEANEDNVKQVIVGYVQPILLNQDLIVGSSASVTLLEIRPLDYFDTTRTQSFQIEMAFHALAYDPSALAPALYNLNVEEFIQVITDALTVASGSIMLSIYDIPTAPRLILGSPPPTLTDFSAGLPYVLTKLHFIGQGAKAANFTGQYLTLSALTRIRYATYPLLDFRFQGFEDTYIMEVQNSTAFNITETTVLLFIRYNTMYDGHNESSIISKLLNGMVTPMGTTVYLANFMNIFGFDFSNLNMAVEAPWIAYSNEWWLPAPPTTTSLPPTTTSPPTTTTSLPYTYTPYPTWTYPPTTIAPALDGGLVWYPYINAFNIHNPWLSPTYTQQGACLAQNQFCLHLKWIVDSSDVYILSRIKAQQYFNTSITASPYGPLISQSPTIWTLYDVPRSNILFDFVRLSDQSFVTVNITANLINTKTARAIVGSQSSNKVYTTFSSIPLEAKAVLLEIHLTNATKPPRVTQTYRYEGCVYCTKLAGQCNNDLDCSTLKTCVESSTTPSDRQNLITTGLYGDSLNTTLPAAACFSNLTASPGRTLFNAYMSCMLDRVCSFATQGPSRLIYRAPTPGWIQIQTALWSQQSSSSLPFVLSYGNNTVCPVVLFNQNNSAANLTAQINACVFGDCEVVVLVNTTSVMTIDVVFNNHIGPMPSIVAMASAGAPIVGYDIVMPSFPVTIVTKLVSSSAVQLMPIYDPKTNPVVLQDPCGSCWLDFQQSCLLDTQCNNYVSCIMNKAFPSIAPLVKRGAVGASFDLNPIIRSCSDASVPMNASWRALQNASHCYGMYQCPVASPGPNIVVWNASSRVQTITYNGTLQASWFQFKYQLDTTWRVLYGGPSDFGWILPSLVGFQDVSVAGPFNRTNADNTTTITWLATFPQYAGFLPVYSISDVRGIPLGVQNDAPASALLVVQPKPWNATTWNQALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XS05</accession>
    <name>A0A6G0XS05_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_002023</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000020">
        <property type="protein sequence ID" value="KAF0743234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XS05"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019543"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF57">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="3">
        <location>
            <begin position="94"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0743234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="217" mass="24849" checksum="5C16A6FE34FAAA3B" modified="2020-08-12" version="1">MPPHRRATGRPSIKNVKRKEAQHQRLFFTNEKKLRIVDFAKQSSKRAAADHFFPGVTGKPLVTLLKRIDRWERGRSKIQALADDPATRSKKSNRQSGWATVLEKEDEEDIVAWVLALRKEGIPVGNLLLACKALETAKKRGYHEDQFKASSTWIEGFKRRWSIALRTKCRSGQANNDQGEVALEAFSKKVKETIRLNDIEDIYNADQTAVNYEYVPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XU83</accession>
    <name>A0A6G0XU83_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_001581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XU83"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012257"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07379">
        <property type="entry name" value="MPP_239FB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051693">
        <property type="entry name" value="UPF0046_metallophosphoest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905:SF0">
        <property type="entry name" value="CALCINEURIN-LIKE PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0743939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="255" mass="28455" checksum="09B72BAB13C65E93" modified="2020-08-12" version="1">MAMAQSATTGKVRFVCISDTHCKHKLLDVPDADVLIHAGDFTNIGTHSQIYRFASWLDSLPHKHKIVIAGNHDASLDAAWYNKDGRKRHKEYQDPTISKQMLTSVCTYLENEAVEIDGIRIFGSPCSPVIPNHVMAFNLMPGRHSISHWQSLPDHIDVLITHTPPLGILDKNHRSYACGDEDLLSEITTRIRPRVHVFGHIHECYGTTVEGPTTFVNASSCTISREPDNPPIVFDISKNDLTVHVHAIPTTVEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XUC0</accession>
    <name>A0A6G0XUC0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_001664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0744031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XUC0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007866"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0744031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="240" mass="26589" checksum="03170411668407A3" modified="2020-08-12" version="1">MPVSACMDPSSKRRIALFDFNKDHHEVTEDEWIAWFNAAIKEEPLDLDVLKRRLTSVVRFDTKICDAESRIGRMLDELMRALEQDHQEWVLTQEGKVVVDVMAKAIKPDALRIAVQKQLQLQKNKALKSDVFRFVNWLRQYAAGFQMYVGLDETPTPTVAPKGEAQRAGRCGGGSRGDGRDKPDAGAKGDGKGGAVAKPAAEKSKEDAKPKKKLGCLKCGDASHRVADFPRPSPARSRSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XUJ0</accession>
    <name>A0A6G0XUJ0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_000829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XUJ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009448"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0744341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="330" mass="37143" checksum="85DCFF6F08242109" modified="2020-08-12" version="1">MSALLYADTPARNTRSSQSSPQQSQENPTSSLYELTVLPMVKDTVGQRNTSSTKLVTYICGGASWSEIKTKIFEKYKAKCLGIAQRNDEGVWSVLDDQVDESSFAKIFSLRSGTHVRKLDTDPIMNDWLRSVRGTQVSLSIYKYGNEIATKEQLLDFTAACIAPGLQDRSGARSESTIQEFMGKQHAKWDDTWEAANQIWQIWASHVVRPPFLAWESRVNQGPPPHVLSRLWPKTSVHEIRMESFNRTIRTALDIVDGSLGELGHIRGAVDVVLQRLTMFEQSLVAKRDILVAMEHDSAPIPSDEVATTELQENQNILDTDHDYTLEDMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XVG8</accession>
    <name>A0A6G0XVG8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Ae201684_001028</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XVG8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004401"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
        <property type="entry name" value="FYVE_like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05123">
        <property type="entry name" value="STKc_AGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000008">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000524">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045270">
        <property type="entry name" value="STKc_AGC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="17">
        <location>
            <begin position="381"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="465"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="35"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="813"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="820"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="856"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="887"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="905"/>
            <end position="918"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF0744554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="918" mass="102352" checksum="19ED01DE12371657" modified="2020-08-12" version="1">MMPASLPDKIGAIRDAVKRKSVAFSGMKSVTSMTSSFFGRSTSTNSETSNGSPPVSARSLSNSIDFDDEDLTSPQNRLSRHGSMDRHSGSMVKIEKPMTLVGSSSYVEPPEPYLPAGGLLESATKNVQAKMIEMLDIYHDSSPCEDKSVECSVFLSRNVAQADRLVIFVGDSAGSPAGIWSSKLCVRSGSEGGGIHHGSLGSMLPYLLRARDDLFGIMVYDDIFQIPADNDTPMLQIAINRFITGWRDHIDTSQASHAFLVCYGEGGRLLVETLREHLPEMRRLLSGIAFVQSTHRVDSTDSYLLRKTLAQWAVSYVSSMEPQLARLKHKEHEAGCIVLSAGYEGSDVEVLQSVLHSVFSAFRARYAGFRTSSVSAGMEKHCYICKQAFNMRRWRRHCRTCQMPICEKCSSMETTKLEGSVRLCLTCRTLPSLVSWSRPRAVRLGEKESVYSDSTIPGKMSVNDFEMVSVIGKGACGTVLLVQKKDNLKLYAMKVLKKDWVMNKDLVTQTMAERRILQEANHPYIVQLRFAFQNNDKLYMVMDYYSGGSLRQVLRRRGRFSIKRARFYLAEILLAIAHLHASNILYRDLKLENIVLTADGNVACTDFGLSKEEVDKETGRASSFVGTCEYLAPEIILKQPYGTAVDWWAFGILMYEMIQGDSPFRHQNPAVLFEKILSDEPVFSERFTPEAKDLVTRLLDKDASTRLGSGPTGADEIKAHPFFNEVDWTGLLAQTVEVPRPPHRQEDVTPESCLSRAIAKTREAREELMPDSPVHMPNSPSAARSKHFDRFSYAGGDVAAEVKEFQKSLNTAAPNGSVIVEEEEDGPQTPQEIEEDMPEEPLTPKNEPTDARELSETPTNTSSEAPRTPVNESTPRDNGQPTHYGDFDDDEDDDDDDDDESFEEYVPKSVEKPKTIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XVW0</accession>
    <name>A0A6G0XVW0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_000730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000008">
        <property type="protein sequence ID" value="KAF0744824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XVW0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007359"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026053396" evidence="2">
        <location>
            <begin position="22"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0744824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="149" mass="15353" checksum="097FA1B56AAFD1BB" modified="2020-08-12" version="1">MFTTALKIVATTMVLLINVQADSVASSVTDPPVDTTATTFSTPQELKKDEGHSPKQDYHGQRDNYYAPNYGHDVYGPPRQESAGYGQYGQYGPNGGEYGSFGGGYGSYGGGYGGSGFGSFGRGVGGGYGNNVGGRTIGRYGGGNGGGNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XW79</accession>
    <name>A0A6G0XW79_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_001176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XW79"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011294"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF68">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4 HOMOLOG 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="43"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0744719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="346" mass="39411" checksum="7C90B3A871B8C2F4" modified="2020-08-12" version="1">MWVTLRKRSFSSSSFSMLPTLVRRAAHPSAPSTFSIAQLNILASNLASPDRFPYVQPELLEWETRKNILMRQLADLRADVICLEECSDYWTFFRPSFLALGYDSVYVKRPSTHSSTWSGDKKMDGCGIFFRQDKFELKECDSVNFRDQHDRVALLALLKEVGTKHHVLVGSTHLWWNSNKVDHQMRQLVELNDEMTQFTAALEAKYAHQLPHGTIPVVLCGDFNNSPTSPLYHYMEKDFLSPTIAMKSAYADYRAIDGTAETGEPPHTTVNYRRCWTIDYIWYSPQHLQRDAILEIASEAELRSEAGPPGWHAVANIPDDGINRNGIPNSVHGSDHVPIMATFSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XWP8</accession>
    <name>A0A6G0XWP8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_000732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000008">
        <property type="protein sequence ID" value="KAF0744826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XWP8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004500"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0744826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="150" mass="15600" checksum="462227DAB4AEFD11" modified="2020-08-12" version="1">MFLLAQGRADGVSTTVAKPPVDATTTASSYPHELKDEGHSAKQDYPGQENNYYAPKYGHDVYGPPRQESLGYGSYGQYGPSGNENGRFGGGYGNYGSGYGNYGSGYGNYGGGYGNYGGNGFNSYGRGVGGGYANYVGGRGIGRYGGGYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W618</accession>
    <name>A0A6G0W618_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_019089</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000389">
        <property type="protein sequence ID" value="KAF0721535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W618"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002834"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13650">
        <property type="entry name" value="Asp_protease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A2" evidence="3">
        <location>
            <begin position="5"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="241"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="252"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0721535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="413" mass="46824" checksum="F17EFB83BE28200E" modified="2020-08-12" version="1">MDRDTIILADTGADMSVVHLRAVESLNLPIDQRKSMRINGIGPNSIRTLGTVPVKLTIGNGIAYYLELDVCDLGNVGFNAVLGMDFLSRAHMTIDTNRREISLPGGEQVPLLHQPTRYHRGNIQYLETTKQIWIASGESVVVPIRYSLPLEHDEHEYWVHRGAKWIATLLSGVDEQPVAVRITNIGSHGISLLPRTRIGAITERGERPLDARMVRKDSNRYRVWEDDVYEGTFTSRFLKKQVAQNTEPEDSNSLKEPKEWPTTLKTHDGELPLLRKTSIASIAITEDMQTKEHHDNDIWEPPGSQIFSLQAVPDLDQSKFDPEVIVKEGIDMTTEEMEAQLAFIPEIIPDPTPIRLEDLDYGEPDRATEVKEKMRAVLRTYFCHTEFVENHTHKSNSTLKTPKTTQILPKYTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W683</accession>
    <name>A0A6G0W683_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_019077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000386">
        <property type="protein sequence ID" value="KAF0721559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W683"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003658"/>
    <dbReference type="OrthoDB" id="64823at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026317584" evidence="1">
        <location>
            <begin position="25"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0721559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="168" mass="19786" checksum="28FE529C57E0F165" modified="2020-08-12" version="1">MFIRPKVAIALFFSAPAMVLRVYSDPLQETAQATPDFLRQKFNVWWKKQSWPKVFAAQPSGDGEIPLVFLHEKYPHNGQKTLRLHDKKYLKMAEMMQQNKHPSELGYVYIFDTKDARELPTGELIQVTGIEWKDDGCFLRTTRKRSFRIKSIRRDPHQGIMYAKVEWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W6D2</accession>
    <name>A0A6G0W6D2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7769 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_019047</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000380">
        <property type="protein sequence ID" value="KAF0721612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W6D2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003947"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008720"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056671">
        <property type="entry name" value="DUF7769"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33889">
        <property type="entry name" value="OS04G0681850 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33889:SF7">
        <property type="entry name" value="OS04G0681850 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24964">
        <property type="entry name" value="DUF7769"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7769" evidence="2">
        <location>
            <begin position="24"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0721612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="345" mass="38220" checksum="6E8F4571CD5FB3E8" modified="2020-08-12" version="1">MPRTNRQSHSVPTDGKIVRRNLGDDERQKVYRLLLERSVEGKLKHGTIAIVLRIVGCHWRTVSRLWAQARASIDKGSLVADVAVKRKGNPGAKSRRSSDEVEEAKSVALDDRQTLRSTAEKSGIPKTTILRHMKTSSILRARSNHVKPILTTKNQVWRVRHAMSLLLPQLCGGHIFANMRDFVHIDEKWFNITKVKRRFYAYNNEALALRRVQSTKFITKVCAGNTTYSPLKKHGAGPGKKVGVIGIGGLGHLEREGVQGALGSAPLHPEAVKAYAQSFDILLCTSYGPTTNWDMLLSLVATLGTFVLVGLPEKPITDGSFSLVPHKLSFVGSLIRSPSQIEERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W741</accession>
    <name>A0A6G0W741_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_018786</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000355">
        <property type="protein sequence ID" value="KAF0721964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W741"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008501"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF9">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="42"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0721964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="107" mass="11308" checksum="30F88FE1F20A3BF6" modified="2020-08-12" version="1">MDNTKHPIAAGKDLLAAAQNGDLNSVRDLLTRGADANFNDERDESPLHWASGKGYLDIVKELLLHGASVDAQSQSGSAGLHFAASSGHLDVVAELLARGAMGCYSFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W7S0</accession>
    <name>A0A6G0W7S0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dynein light intermediate chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_017826</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
            <location evidence="1 11">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the dynein light intermediate chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000313">
        <property type="protein sequence ID" value="KAF0723208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W7S0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009498"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008467">
        <property type="entry name" value="Dynein1_light_intermed_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022780">
        <property type="entry name" value="Dynein_light_int_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12688">
        <property type="entry name" value="DYNEIN LIGHT INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12688:SF0">
        <property type="entry name" value="DYNEIN LIGHT INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05783">
        <property type="entry name" value="DLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8 11" id="KW-0243">Dynein</keyword>
    <keyword evidence="5 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="408"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="413"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0723208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="445" mass="49360" checksum="AA8DA153063520AD" modified="2020-08-12" version="1">MANLWQSLLRESSVRSPIPSTEILLLGGTEVGKSSILQRWQGAKPSSIERQIAVLPSDFTSFYVPTEDDPLCQFNVWSFNTDGLASELSLLSLSIDAQKLKQTVALVAVDASKPWTIKTTLEKVSTGFTQKFTRIQWLSTLHTVLQEKKASLNAAQADELDDATRKHWLHYVEPGQNAQSAASSAFLKDDDLPKTLPDGVLTHNLGIPVIVVVSKTDLTPEDTVKVDFVQYTVRQICLQYGAALCYTSSKTGTNCDVLKDYIMYRSHPQAFKFAQAAKLVDRNAIFVPSGYDSSDLIEQSLVGSQPRWQKNAAFDKLLSAPQDKTEDSALLHPEIRVDPNQVWLRKLEKAAGSGLADLQKSSVEASRRVEELAAARRLEMDTRSKEKVDVAKKETKDVNPKHLANFFNNLLSRPDKQKSGRLGAGDKAKSAKDVKELAEEELKKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W809</accession>
    <name>A0A6G0W809_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Diphthine--ammonia ligase</fullName>
            <ecNumber evidence="2">6.3.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Diphthamide synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Diphthamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_018560</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>diphthine-[translation elongation factor 2] + NH4(+) + ATP = diphthamide-[translation elongation factor 2] + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19753"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="Rhea" id="RHEA-COMP:10174"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16692"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.14"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.14" evidence="2"/>
    <dbReference type="EMBL" id="VJMJ01000340">
        <property type="protein sequence ID" value="KAF0722268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W809"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021556"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017178">
        <property type="term" value="F:diphthine-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01994">
        <property type="entry name" value="AANH_PF0828-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000145">
        <property type="entry name" value="ATP-binding domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1490.10:FF:000001">
        <property type="entry name" value="Diphthine--ammonia ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1490.10">
        <property type="entry name" value="putative n-type atp pyrophosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002761">
        <property type="entry name" value="Diphthami_syn_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030662">
        <property type="entry name" value="DPH6/MJ0570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00290">
        <property type="entry name" value="MJ0570_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196:SF2">
        <property type="entry name" value="DIPHTHINE--AMMONIA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION 71 DUF71 -CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01902">
        <property type="entry name" value="Diphthami_syn_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Diphthamide synthase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0722268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="650" mass="72556" checksum="3834C0E34D15A7B4" modified="2020-08-12" version="1">MKVVALVSGGKDSVYSMMKCVEYGHEIVCLATLQPPKSNSEVDSFMFQSIGTHVVEHIAECMELPWVAHTLQGKSISTDMGYSATEGDEVEDLCCLLQEVQKRFPEVQAVSTGAIFSNYQRTRVEHICARLNLISLAYLWRRPQDELMQEMIEADINAILVKVASMGLVPRRHLGRTIADLYPFFLDLNEKYQFHICGEGGEYETLTLDCPLFKKRIVILCTNPSAFGRHDCSNSVEDVAKTSFRAFTPVFPCRPLAKKHTISVSTKRSHVFRDQIVLSGVVSKNVSLTLAEQVHNVCQQLQDTLVGHDLSLPSVAFVHVYVKDMATFGAVNEIFAKYFPCHNPPSRSCIEVNMAEDVMMDCWAIRNSTKRKTLHVASISDWAPTCIGPYCQANVLNSSLILSAGQIPLVPATMQMAAQEHLPQCLNNVLGVLEALESNLRHVIAGILYTIEPQDSLADETQLLLNANLHHRDAYESDDDDSLDEDDINEKSISTQVQVPLLCITVAALPRQASLEVEFLALTHQAMNLFNPQSFQFQDDAFNSEWTIVPRMLCVGFCYLSSSLQLLDASSLRSHVLRVLGKANLVWKSLLHMRVHHVENSPDLTSLNVPMTFVPTHHISHKSSAVSVAIQVVAYDGELMETDLWLARKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W881</accession>
    <name>A0A6G0W881_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_017768</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000311">
        <property type="protein sequence ID" value="KAF0723285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W881"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008579"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
        <property type="entry name" value="FYVE_like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="START" evidence="6">
        <location>
            <begin position="146"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="5">
        <location>
            <begin position="267"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0723285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="411" mass="47086" checksum="D1F012EAD3594BC8" modified="2020-08-12" version="1">MPLKAPVPPEYFKCPPLSQAENSRYVDMAEQGIQTLLQKAQLVGGPYEWKLLKDDSELKIYKGHGHGTTKTSVLHCGVMQVVGELEENMEIYRYDTTDQAREYIRRFGRAYVDFVRLYTVLPRHRDRPNDAIHIKWILAKSPLDGLVARRDFVVLESDLELKVGGKRAWVRAVHSIELDAVPDMRKELGCIRGYMYNMGFVAMESDRPGYLDMTYLADMDVRGKVPSWANDFSLEAWIRSMTDIDRFMRENRLSRTPFLRDDELWPLDSSHSCSLCRQKFCPWRVKTNCFKCGEVVCRGCNRLWHVTINGQNRKVRACVTCSLSAGTAVTPAKKTSRSSRPALTPHNWTDILSQISEWTEDKVAVIAEADDVKSIDLSNYGDSGRERSTEDVVVLEIPSMRRLPDKEHPMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W9D1</accession>
    <name>A0A6G0W9D1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tetratricopeptide repeat protein 29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_017383</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000295">
        <property type="protein sequence ID" value="KAF0723808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W9D1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018258"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051476">
        <property type="entry name" value="Bac_ResReg_Asp_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46630">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46630:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0723808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="406" mass="45709" checksum="A9024CB4D14A6B94" modified="2020-08-12" version="1">MAMRVPPVGSKPVRKQPLRLASYSDDNDGNPESSNASNTCSMVDKREVCAQVLREGLVQSFVDLFYLIHRVDTIVTPEGQEKKEPVAVSPTEMTFLRDNLTSAEKARRQGDVVHVYESYERLAIHFMNLKDLRTGVFFYEKCLEIARISRNQDFELAALENLGNAYYGLKEYARAQENHELHVQLVKALRGAATTATAELTTVYQQVALQHETSGDFPLAIATHVKFIQCAQESQDIANVAVGQYRIGCCYNAMQQPTDALVYLKDYLVMCKNMNDVPGECQAYAALATTFEALGHKQQAMEYLKEYLITAEKIENIPAQAEACRRLGMLYSANREFNLATEMMERNFDLIKNSTKSDSSLLDQARISLGVIRAHEKFSAFVEFVTTDIEGFLQWKASRAIESKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WA48</accession>
    <name>A0A6G0WA48_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_017156</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000282">
        <property type="protein sequence ID" value="KAF0724105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WA48"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0724105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="114" mass="13319" checksum="3EAAA21B1CE56211" modified="2020-08-12" version="1">MARLARDEREVFNHEDNREDHIRAEIFASFPVGGICKYPPPVSYREYSAFSKRLRRLIQNRAALVGTTNVALALIKAMKAYPMSSQKWREYKEFVRREDTRANAMKAKEAARRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WCD6</accession>
    <name>A0A6G0WCD6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Hsp70-Hsp90 organising protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Stress-inducible protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ae201684_016490</name>
        <name evidence="16" type="ORF">Ae201684_016491</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as a co-chaperone and mediates the association of the chaperones HSP70 and HSP90 probably facilitating substrate transfer from HSP70 to HSP90. Stimulates HSP70 ATPase activity and, in contrast, inhibits HSP90 ATPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer. Homodimer. Forms a complex composed of HOP and chaperones HSP70 and HSP90; the interaction is stronger in the absence of ATP. Interacts (via TPR 1, 2, 3, 7, 8 and 9 repeats) with HSP70 (via C-terminus); the interaction is direct and is stronger in the absence of ATP. Interacts (via TPR 4, 5 and 6 repeats) with HSP90 (via C-terminus); the interaction is direct.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000254">
        <property type="protein sequence ID" value="KAF0724930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VJMJ01000254">
        <property type="protein sequence ID" value="KAF0724931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WCD6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013581"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000016">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000020">
        <property type="entry name" value="Stress-induced phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="11">
        <location>
            <begin position="96"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="129"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="751"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00056105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00066016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00076447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF0724930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF0724931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="786" mass="86718" checksum="0792443189300575" modified="2020-08-12" version="1">MAPQRRRAGKGTKDAHANLSAEERTKLGTEAKNRGNEAYAAGDHATAIKEFTAAIGYEPNNHIYYSNRSAAYLSAGNAALAMQDANKCIEIDPKWGKGYARLGAAYYYIKSYQKAVTAYTKGLTLDKGNKQLQTGLTQAQAALQVLEEEASGVEMDDATRKLKRMEIEEKINKARAEREERAKRAERGFSEVIGIDLGTTYSCVGVWKDGQVEIIANSEGNRTTPSWVAFNESERLIGEAAKIQAASNATNTVFDAKRIIGRSFSDPIVKKDAAHFPFKIVEGEDDKPLIEVTFKGEAKRFSPEEISSMVLTRMKETAENYLGQEIKQAVVTVPAYFNDQQRQSTKDAGAIAGLDVKRIINEPTAAALAYGLDTNAGAEGKSNILIFDLGGGTFDVSILSIENGIFEVKATGGDTHLGGEDFDSNMVDFLITEFKRKNRNLDPTSSARSMRRLRTACESAKRMLSTTTSATIEVDSLFEGVDFSSTMTRAKFESLNDECFKRCEETVLKVLSDANMKPDQISELVLVGGSTRIPKVQNMLSTLFGGKELSKSINPDEAVAYGAAVQGAILSGIRNDATNSLLLVDVTPLSLGIETVGKVMSVLIKRNTAIPVKKTRVYTTEADYQTQVNVVIYEGERVNVEHNNKLGEFTISGIERAKRGEPQVEVTFEIDANGILNVSAKDKKTHAKAETTISNNRGRLSQEDIDRMVADAEKYKKDDAEALRKIEARNNLEGFIYRALEIAREKGDSQAENAIREAREWLEDHEEATLRELEDKKRMLERLIKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WD19</accession>
    <name>A0A6G0WD19_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_016332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000249">
        <property type="protein sequence ID" value="KAF0725180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WD19"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015711"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0725180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="369" mass="42821" checksum="19498C7318E55846" modified="2020-08-12" version="1">MAILLTRIFFGIRMMEFCIWIDKSQANSAHYVVYAARVFNEPSESIWLKFIFCCFVSFYVGYGLWTNYYAHYGLLVMNLSTLGLSKDYLWYDIVVGDPAYAILSDPIVSIAMVIDIWWSMFYVTFGVMRVIQLQDFAVYINGCLYLSPYVWFAYLGMRTMSFIVKWRRWEGSFACVDPGVLAIVAYIYSGPIITLLGTTRLVGLFYFLWKIGLPAELYYQGTESVSVVSFITVLMSKLPLPFSWSISWWRRRKTNRVEPFHARKLSGHMSHYTYNDMKAFILLSLTMKRLFKRCSGGSLHELYEMSPRYRKLPLYSHRAADCFILCYKADGHLDSQVRLSLLCAWICNQTIPTGRFGHARPKCTPIVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WDP5</accession>
    <name>A0A6G0WDP5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_016116</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000243">
        <property type="protein sequence ID" value="KAF0725343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WDP5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002255"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010992">
        <property type="term" value="P:ubiquitin recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849:SF1">
        <property type="entry name" value="F-BOX_WD REPEAT-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="5">
        <location>
            <begin position="107"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="197"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="259"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="299"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="382"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="424"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="36"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0725343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="498" mass="56324" checksum="39C84EA79E5B036A" modified="2020-08-12" version="1">MDTKESLERENAYLRQELDLFRGVLSVMQEDLNVKNEQIEHIFSRLRASLENQEQQASKRELQTRVDHLECVLRATDEKYARVQKDLLRAKCQLYRQSQAPFTWCADDVTVKIFAFLDVISLHAVLLVNHSWHDMVMTDMFWETMYFRRWSQRVCLSQINETAIQPNNQDHRWVETYKERHILEHNWSSGKAVITTLSGHNGTVMCLQFEDDSLVSGSDDGSLMLWSLAPRSDDSSQPINLLAQQHHRQTRAVQKLYSFYGHGGPVWALRIHGNTLISGSYDKTVKLWSLQSAQCVGTLRAHTGWVSSLDACGSRIASGSWDSTVHIWNADNGDLVTTLNDEPANPIYCLKWEETCNVIATGCRRRGIQVWDAIQGRCIQTFLGHSRGNQVNGLQAKGNLLVSGGSDSTVKVWDRRDSTCASTLEGHTGAVMSVDLHDNSIVSGSYDRTIKLWDIRRPKSCVQSVEGHASAVFALQIDLVKIISGSADTTIKIFSFHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WFL3</accession>
    <name>A0A6G0WFL3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Leucine-rich repeat-containing N-terminal plant-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_016265</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000247">
        <property type="protein sequence ID" value="KAF0725248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WFL3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001641"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454:SF56">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026166397" description="Leucine-rich repeat-containing N-terminal plant-type domain-containing protein" evidence="4">
        <location>
            <begin position="18"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0725248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="263" mass="28306" checksum="6E3FEC7181186F31" modified="2020-08-12" version="1">MMFKLLALALVAARVNAARGATLRECQGFDGNFPLPCLQMDSTTVLLEPNYTLDLSKQSISTIDVLPSMATSLDLSFNSIQSLGSQPIPPRLKALSLPATLETLDLSYNQGGMAWFSMAQVATSNLTHLYLRGNNLSTIVLTQQTLPPSLTYLDLSDNPNVIVFADRSTYTSLARQQIVLKVNTSLATVSGFCLGSLVLPISPTAYVCIEIEGWATAPPSQAPQTTMPSSTSSTTICIYVATIVGVMWSIFLILYIVTVSETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WFT9</accession>
    <name>A0A6G0WFT9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Restriction endonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_015992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000237">
        <property type="protein sequence ID" value="KAF0725659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WFT9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013975"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0725659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="33782" checksum="58D2B23D5CD6F659" modified="2020-08-12" version="1">MKPSKPTSLAAKSSSSRHTASPLVQESDDHRVARVQQALDEIDACPVESAPFRDSDGDPSWGPVVLFESISSGEFNEWLANNEARVRRWQFEPLDDDDKGRVVIYSRPTGVLTEVSDWIYNSIIEQIVAAGNNDIRLMRSVSSSGSTTFQVGDGLCFYAQEEDNSLKPVNLRVGGQVLAGTATQDPFPTVVIEMAYKNQTFDHLLGKIRSWMHPQYTSVQVAIGIHISPVSGRRRAILHVRGQAVQVTEFGDDSAIVPLPLVFPMACIYWGVAWPNALSGHENDMISIDLIALRRFIRYCIDRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WHR4</accession>
    <name>A0A6G0WHR4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-oxoacid CoA-transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_015125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000210">
        <property type="protein sequence ID" value="KAF0726727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WHR4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013045"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008260">
        <property type="term" value="F:succinyl-CoA:3-oxo-acid CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1080.10:FF:000001">
        <property type="entry name" value="Succinyl-coa:3-ketoacid-coenzyme a transferase subunit b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.10">
        <property type="entry name" value="Glutaconate Coenzyme A-transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012791">
        <property type="entry name" value="3-oxoacid_CoA-transf_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02428">
        <property type="entry name" value="pcaJ_scoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="KETOACID-COENZYME A TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707:SF23">
        <property type="entry name" value="SUCCINYL-COA:3-KETOACID-COENZYME A TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0726727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="311" mass="33617" checksum="26ADDA47BD058810" modified="2020-08-12" version="1">MEEGITGDFALVQAWKGDKDGNLVFRGTTRNFNVDAAKAGKVTIVEVENLVEVGDLHPDEIHVPGVYVQRIFKATKNEKRIERLTVSDNAKSAKITPDRERIIKRAAKELQDGMYVNLGIGLPTLAPNYVPEGVKVVLKSENGLLGMGPYPKMGEQDPDLINAGKETVTYLPGSSTFSSSESFGMIRGGHIHLTILGALQVAQNGDLANWIIPGKMVKGMGGAMDLVGSGDRVVVTMEHNAKNGSAKILKSCKLPLTGKQVVNRIITELTVFDVTPQGLVLIEHAPDVTVDDIRSRTEADFTVSPNLTTME</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WIH9</accession>
    <name>A0A6G0WIH9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_014873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000203">
        <property type="protein sequence ID" value="KAF0727008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WIH9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018057"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37558">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37558:SF1">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0727008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="244" mass="28381" checksum="303B4BBE6F1EAA59" modified="2020-08-12" version="1">MEEGASNENKRKHAFRFKAASDVDLLKEVIHVQPFDAPFGQTKLRWDEVADQVTDIYGDVVTVMCCRKRFDDLMSAFKHDTVKALRASGTEEEYNEREQLLQDISDLITESNDRKQATKDDRINKHNKREVDGELIRSAALGQIKRAFENGTKIYDNGDPSIPEKRQRRDPEPADFMIEFAGVMKASNELKRDEITLAQRKMDLDEARFAYEKAEREARFNLEKGEREIQMKMMMELVKKLNKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJ80</accession>
    <name>A0A6G0WJ80_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase M48 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_014667</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000199">
        <property type="protein sequence ID" value="KAF0727250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJ80"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004202"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07331">
        <property type="entry name" value="M48C_Oma1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051156">
        <property type="entry name" value="Mito/Outer_Membr_Metalloprot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726:SF1">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M48" evidence="7">
        <location>
            <begin position="35"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0727250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="204" mass="22842" checksum="2A68301C75596D56" modified="2020-08-12" version="1">MLVSPETERRLGEETFRQVLAQHRNDILPASDPKSRMVKRVGQRIARVSGQNDFKWEFVVIDSPEANAFCVPGGKVCVFTGLFKTLRHEDGLASVMGHEIAHALARHSAEQMSLSALLMLGLLFLPPESIQIVRVAFSLGVDLPYSRKYELEADAIGLELMAKACYDPRASPQMFADWDKKKLGQSLKYFSTHPPNSERSTILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WKI0</accession>
    <name>A0A6G0WKI0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NodB homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_014260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000189">
        <property type="protein sequence ID" value="KAF0727744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WKI0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012954"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026253317" description="NodB homology domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0727744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="409" mass="45947" checksum="DA6407485A9E0A60" modified="2020-08-12" version="1">MYAVFLVWNIIAFILANNKDDDGNNSASAEGGLNHTGGHGNRTDEKWPSALPYTFTPMPTEDNTTDSDTITPVYRFPKFVAAAPLTPVPTTTTCDSTFRRAKSPNEVVYITIDDGPSASGRINLLNVLTQINNRTDKAGKPVTPAYVSFMESGYNFCGPETIDMTMLQCVPGAYEQARRSLVWTIKAGHTICAHSDTHFYDATSGFCNYQKMNAQTKIEAQYLNCGNTTASDFVRGALRVQTALDNETLWETDDDRAAWKKAISTLWTYARLPCTNEWILPGVRTVTGLRREDQGAEGDLRMKTGDMMFAGKLPCKNDTKPWYSIGWDAEWRLDAKTTYDNQKEKCRVVKDITNQFDRKDKWGPKPSNVVLLTHDYFFLDMAKATIFRDIIVELQLLGYTMGTIDKYPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WKL4</accession>
    <name>A0A6G0WKL4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CLASP N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_014242</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000188">
        <property type="protein sequence ID" value="KAF0727806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WKL4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016288"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024395">
        <property type="entry name" value="CLASP_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12348">
        <property type="entry name" value="CLASP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CLASP N-terminal" evidence="2">
        <location>
            <begin position="14"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0727806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="774" mass="86498" checksum="2DC61DDE5EDE29F9" modified="2020-08-12" version="1">MDELLLQIEICGEILKNPGVEWTSRVNHMKQLEAAACAMSKISHYSPARIVQQLMPLVDAFQQALADSRPAVIKQTCSLVGTLAWTCGASFGPITEALLVPMLLMATKQKQTQVIAFAARQCLHSMSKASRYSLTLLERTFHRARREANLRMMCTSLLVLVLRYWDPEDVLATENYMPLRRVILRSLQDKDTAVQAQGRMALCLLCEYGQESMAELVVSIPFDIFERVVAEYPDSLCATERRRLLFPEEPQVEEEEDGGEMSLLSAIPELEGEQEEDNLPEEEISGGDDDEDDMSHIMIMPKAYFRPSEWTEEPAWSDSSASSSPELENNDPNVEYIEPELSFDANGRNASEHEMTMDAWLDQAKSRSPGSTKSSETESRISVHDLPTDNNDDDKDDESQMNEHLIANSTEEPFEPDFIFETNEEVNLGSLETHNDAPIHTAHVVDDVKKNGHETVARPVQPMKHPMQSLSLPEEPKLIALQRILSRNTSLSDIEMPVAQDQDIRDPPSRRANLTHVAQANTRSNKLYEAPVPPTTPPPKFTHRSDRYTLDADLTKQKLPMTSLHSQVQAKPTQVELSTPLKPQPTVELTKSSPSVNVQKLESTLDSIILSMDKLSSKLTPEKLTLDRIPSIAPFVPRPSPRAIVAPPADSLPLPEPFVKPQEAPCPQPSPAPDSDRVMWDWTFAALWCISLIYAVAGITAAVNAHYSYSSPSVQFSRVHLDFQLQEAVQAASRQLSSTQTMLNAWTEDMMKVKARLEEATEEDDKPVESIGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WKL7</accession>
    <name>A0A6G0WKL7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PhoD-like phosphatase metallophosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_014227</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000188">
        <property type="protein sequence ID" value="KAF0727790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WKL7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019131"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33987">
        <property type="entry name" value="CALCINEURIN-LIKE METALLO-PHOSPHOESTERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33987:SF1">
        <property type="entry name" value="CALCINEURIN-LIKE METALLO-PHOSPHOESTERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09423">
        <property type="entry name" value="PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026153118" description="PhoD-like phosphatase metallophosphatase domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase metallophosphatase" evidence="2">
        <location>
            <begin position="134"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0727790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="494" mass="55439" checksum="C90527C6AE70D314" modified="2020-08-12" version="1">MRRALVALFGLSASLSTEACRDVQGSPVKWTWIGALTSSSFRLRVSTAFEDPLCDPSKVSLWLYSNDKSDSPVQVQGKRRIMSPTKSVHDFQAKDLLPGAVSYEVRYDNSIVLKRSNRSIHLPGIEGTPQSFKFAFSSCADEDSDPQVFKEIERHDPLFFVHMGDLHYANIEVNDVNVFRNAYESMFESPAGQAMLAMEFPMAYMWDDHDYGPDNSDGTAPGREASLVAYREYAPHYPLADSDPLGPIQQAFTISRVRFLMTDLRSQRTPNTDPDVPTKTVLGAKQMKWFQEQLLAAAAPEIGLIVWVNTMPWIDDERKWGHFTHEQRAIVEFLRTNNLNSQVPIIIISGDAHMLAVDDGSFSPGNLTTFHAAALGRPGSTKGGPYSHGMFPGSGQFGVMDVHDDGEKICLTYSGRRFGTELLAYDTCHTVVGETYYPPPKFVRVLTRTWKKLQSRVISRWNKSQAHEIVGMALLAVLAVALTRRWLKRHEKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WL04</accession>
    <name>A0A6G0WL04_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_014062</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000184">
        <property type="protein sequence ID" value="KAF0727950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WL04"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016443"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0727950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="213" mass="23881" checksum="6E6189FF2CF24B4C" modified="2020-08-12" version="1">MVKRSDLFRKRALSMVSFGIHHIAETNPGVFRASGGMELFTIDAAGNASLRDPDLCFAKIGGHKPTLIAEVEERHRSVLSLDQWWRGYFHTPGVRLVLGFKLYPAQLNGNVAALVLQYGYTSGNQVEIMDAVSFGMRDVEPQGIPHDIWSRIRFLPHPTRAQMESCLDPWTPDDHGFLTLPRAECLHGAPADVLNSSVEDFRLPLFKILVHYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WL29</accession>
    <name>A0A6G0WL29_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LCCL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_014077</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000184">
        <property type="protein sequence ID" value="KAF0727968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WL29"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000486"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.20">
        <property type="entry name" value="LCCL-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051957">
        <property type="entry name" value="CRISP-LCCL_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004043">
        <property type="entry name" value="LCCL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036609">
        <property type="entry name" value="LCCL_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331:SF1">
        <property type="entry name" value="CYSTEINE RICH SECRETORY PROTEIN LCCL DOMAIN CONTAINING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331">
        <property type="entry name" value="LCCL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G08630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03815">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00603">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69848">
        <property type="entry name" value="LCCL domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50820">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="LCCL" evidence="2">
        <location>
            <begin position="102"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="437"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0727968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="518" mass="57723" checksum="BCEE10B308C6A51E" modified="2020-08-12" version="1">MLRRQSDDSYDEDGSPKEDFLMIRPQFKKWTRWPILHFGLFVVVSLSSLIILLYYGFFAAKVEGTTPAMIGCRNFAYWTGPTCGLNGIDCQPFESDWQPIRCPARCLWDGASNLQVFGSGPYRGDSRICRAAIHAGVIGSNGGCALMKYSGSQTSFQGSAAHGVVSTSFASWFPKDFEFMAAHDVHNCTDLTWWILIVGLLANFGLAIFPIVPPIVLIHTLAIWGYLYVSLVIAPTSYDYLEIVLQLATQVFFVIVSVQCMFHWFIKHTFASFASLSLMNRLFIWGVCYVLPFHILLHLSFFSFIPWLNIDLGGYKYDKVLNTAAYAVIIVGSVMSLVAIGFLLYYLYLQHKLRSTVVGYATLALYCVIVFVFFPHSILHVHHVMIGLILIPLTRVPRPIAFVTQAIGLGLYIQGYAAWGWPSFLETLPASFLIDVASQAPKAYNVTASSANITWESLENVYGYSLMLNGVMAYRGRETWTLLNGLQPKLTYFIQVSGVGDGGNDGLLSPEGNFTTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WL57</accession>
    <name>A0A6G0WL57_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_014117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000184">
        <property type="protein sequence ID" value="KAF0728011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WL57"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0728011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="106" mass="11932" checksum="89953400B346CCA6" modified="2020-08-12" version="1">MTFPMKFFNTRPSPCLECKRFGTSYSRKDRLGRGYFCSQDCFMAYKSHHHRPSWPASDTSESDASDISVDDSKRPTDASSVDFANDKTTTSSSPYSPFVLGDGFFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WMU2</accession>
    <name>A0A6G0WMU2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_013633</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000175">
        <property type="protein sequence ID" value="KAF0728675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WMU2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002589"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0728675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="155" mass="17434" checksum="25E4F7FF7297C1AB" modified="2020-08-12" version="1">MLPRVSCQRRHRVGLSPIVSPLRFQSIQGEEITANVFFDVLLPEKALNMAKRRLSHRKQYRRAMASELSNDERKEIGLLGPHGRLALPNACRCGPPGDEQTYIPSTLRQLQTLVAKHIDACQHMADVRGELDQFLSSNLPKTGALVDYSVESLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WNN8</accession>
    <name>A0A6G0WNN8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">UNC-50 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_013257</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the unc-50 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000170">
        <property type="protein sequence ID" value="KAF0728955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WNN8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019426"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007881">
        <property type="entry name" value="UNC-50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12841">
        <property type="entry name" value="PROTEIN UNC-50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12841:SF6">
        <property type="entry name" value="PROTEIN UNC-50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05216">
        <property type="entry name" value="UNC-50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0728955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="33946" checksum="EB6BC1EF68A201D2" modified="2020-08-12" version="1">MMEPLPVTMPHGLVQQEENIGFKPKKSSWSSSRPVLPSTRQSNKLAVFRSCSALPEYFWRMVDYRQMDLEATYYQMVSLCISPNKVYKSAFYRKQTKNRWARDDPAFAVIQVLFLLVASLAWTVAFEKTSSLAFLVFCDVVVEWLLLGLFISTATWWCANNFLRLTTPGGSERGGASDTFFVEQTVEWQYAFDIHCNAFFILFLLVHVVQFFLVPLLISTSFLSLVLANTLYAVACASYFYITFLGFMALPFLHNTERFLYPIVAVGGIYLSTLVLKLLFGATFNFASMSAFYYYSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WP99</accession>
    <name>A0A6G0WP99_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_013141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000167">
        <property type="protein sequence ID" value="KAF0729163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WP99"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011579"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0729163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="194" mass="20841" checksum="EB4C6A720CBCFE8F" modified="2020-08-12" version="1">MTAEEAPARVTPVKETLSAKMKQVTPTIQMKDETVEVTVQDETLVVNVDQDKASATNEAAPVTLITTPSAKESPKRDRSPPRMKREIECPGAPKKKKRRKLRNTPQLNLDPEETHSPSITVVVRSLEDELRAAAEADGHIEHLSTSDASCTLLSLVSSSNPSTPPPTEPLSSPKSPPTAATPPLTVVPISPTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WPF2</accession>
    <name>A0A6G0WPF2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_013000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000166">
        <property type="protein sequence ID" value="KAF0729249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WPF2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015003"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04212">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIT" evidence="2">
        <location>
            <begin position="76"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0729249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="143" mass="16525" checksum="95C1338B295D53B3" modified="2020-08-12" version="1">MRCRWQHQQCWNEANSKPHSRVSFSQADNSYTLLCRTTTDLGKVKTCIHFATRLSTMKEQSAPTPGQPNSQQIKPIDQAIRLIQQAVEQDRNANFVLAFRLYMQSFEYFMVANEHEAKSIGKKIHRGQNERIHDPRGKPQGIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WPR0</accession>
    <name>A0A6G0WPR0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Deacetylase sirtuin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_013078</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000166">
        <property type="protein sequence ID" value="KAF0729332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WPR0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018403"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF10">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0729332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="293" mass="32919" checksum="673B90AB78E84081" modified="2020-08-12" version="1">MPRILELQKLQELLNKSEKIVVLTGAGISTESGIPDYRSAGVGLYARSNHKPIQHMDFMTSAATRQRYWARNYMAREAWRAVQPNINHLTLAKWQTSTKRKWTIVTQNVDRLHTKAGSTNVVELHGSSEEVICMHPGCTAPPIDRDTFQAILERLNPIYADLVHQDAASRSSQDKMRPDADMFLSPVMERAFQPAVCPYCGHAMYKPNIVFFGDAVPRAKVDHIYDELRESDAMVVLGSSLQVFSGYRFPVRAKEWKKPLAIVNIGPTRADGLADIKIESKCSDVLTALHLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WQF9</accession>
    <name>A0A6G0WQF9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_012705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000162">
        <property type="protein sequence ID" value="KAF0729644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WQF9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018852"/>
    <dbReference type="OrthoDB" id="75678at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0729644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="120" mass="13302" checksum="8CC78EED23D836FF" modified="2020-08-12" version="1">MCCPNRSTIVHKPIKQSKRTDQIMRLLKTAYEAQFKHASGKSFIALALKIERILYREFPADVNIVMSTDVLAVKLRFVIAKVLQAKGNAAHARTRTTATSTTTIATVAKPPAFSIQSMLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WR78</accession>
    <name>A0A6G0WR78_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_012568</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000159">
        <property type="protein sequence ID" value="KAF0729929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WR78"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002617"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF214">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="112"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0729929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="387" mass="42688" checksum="CF27BE35DB66CD21" modified="2020-08-12" version="1">MGCTPSQPQVAQPTASRVSSYYHNNKSADDTNTSGYYVHGGSTNGGTRTAGTSSNGVGSRTGRVTMPRSPAAYQSAAELNKTKLEDIDWSEYQEVLPILAPLHNQFYIDFEFLTVVRPIKSNYMKTEMANFNGESVLIKYAAITGAPADIAKAKRAIVTEITSMSRLAHPNVVEFKGFSISPEKGLVCVTEHMEGKTLRAALDNPKLFMRYTWAKEKINFAIDICSALAYMHQLSPKLIHRNVKASKVLLNKTRTRAKLSGFGSSRDRSFEQTMTNQVGDVEWSAPELIMEAEEYTEKVDVYSFGMLLTELDTGLIPFADVKSTMAQAAFTNKLIVGALRPKLSPDCPSAIATVIKHCLQQDAHVRPSSMEVLKMLQRAKAELSRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WRD8</accession>
    <name>A0A6G0WRD8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_012603</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000159">
        <property type="protein sequence ID" value="KAF0729965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WRD8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009844"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03213">
        <property type="entry name" value="ABCG_EPDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001480">
        <property type="entry name" value="ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF139">
        <property type="entry name" value="PROTEIN SCARLET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="378"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="485"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="519"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="603"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="49"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0729965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="629" mass="69839" checksum="25E6FBAE6BCAC45A" modified="2020-08-12" version="1">MASTEAAPAGDSHFITISTPKAGTEELASTRASSPMGQLRKVPKLSIEWKIDDVSVKIQKPKRQVETKTILKNVNGVASAGQLVVIMGPSGAGKSSMLDIIAGRNKNFTGSILVNGKPWNADTNKRACYVMQDDVFYHTLTVEEHLQYQAQLRMGGSASHEQRNTRVQFVIDELGLRKCKDTRIGNTIIRGISGGERKRLSFATEILTNPSLLFVDEPTSGLDSFMAESVVQQMQKLAQDGRTILTTIHQPSSELFALFDMLYLLSNGRTVYYGKAADSVAYFASIGYQCPNYMNPTDYFMKQIIQLDPEATKRVGAMVDQWLAKEAGRTPPKLENASDAELAQFKESRLGYFGQFAVLYKRNITRLVRDHMAFKARFFQSIFISVIVGLIYLNLEISQTGIQSFSGVLFFVTINQVFSSANSEFIAVPLELPIMSREYSGGLYGSSIWYFAKNVSELSFQIFFPMIFLIPLYFMVGFGSTNATLFFTFYLFLVLLNSTATGLGYMVSCMVRRADLAPVIGIVIILPLVLFGGLFINADNTPKYFIWLEYISPLKYAYRGVMRAFWTSVATIPCDPTRASCTSTGEAVLKNASLDKASLTVDALALVGINFGFRLLGMLFLARNVKKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WSD1</accession>
    <name>A0A6G0WSD1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U3 small nucleolar RNA-associated protein 15 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_012357</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000155">
        <property type="protein sequence ID" value="KAF0730363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WSD1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012513"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018983">
        <property type="entry name" value="U3_snoRNA-assocProt_15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19924:SF26">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19924">
        <property type="entry name" value="UTP15 U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 15 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09384">
        <property type="entry name" value="UTP15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="117"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="159"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="247"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 15 C-terminal" evidence="7">
        <location>
            <begin position="351"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0730363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="511" mass="56565" checksum="6B6DCFC8BD08CF1A" modified="2020-08-12" version="1">MEFQKLPLKQFPRATKTVTPEKAYWSKLRAPHELKQVAMISSIEANPAAPHEFAIATSTRVQLYSTTANEIVRTFSRFNDVVYAASFRADGKLITTGNANTQVSVLDVGSRTVLRIMNGHKGAVRGVKFSKDNVHIFSASDDTTCRYWDLATGTPVSVMGDHTDYVRHAVQHPSSVHVWATASYDHTVKLWDMRGSAASVSSNLSMDHGAPVEKCLILPGGNLCLSAGANVIKIWDLLSGGKLLHEFSSHQKTITSLTLDGTQTRIVSGSLDGHVKIYDLASYQVLHGFRYKEGVLSAALTPSNSHLAVGTVGGMLTVRRRITHEDEAATDELPVVRGGSYKYFLRGTRTKPSEADHVITTRRHAKCAPYEQSLRSFDYRKALDNALDTRNPTVIASMLEELRLRQGWQSALAYRNEETLEPLLSFCIRYVVDPKYSALLLRVCTFLLELYGPLLGTNQSSVVLEGLFFKLKNKLKEEQQVQNSLLQVMGMVESIMTAQSTAHTTTETEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WT91</accession>
    <name>A0A6G0WT91_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_012066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000153">
        <property type="protein sequence ID" value="KAF0730647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WT91"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018755"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="197"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0730647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="238" mass="27699" checksum="9F905DC3997FB59E" modified="2020-08-12" version="1">MPIAVQPVHKQSDDLYNDRGFASNEERVALTPADDIKKERKTRFAYKEADDVKLLQEILSDDGLFIDGTKDVLQWHGIHKSLQSGGMDVSEHGLKRRLKTIYDTFCVAERTSQRASGVEEPLDEKTQLLQEYHELLCERQATGGRAISDAALNTFDRSSSLENEKDPLKFDVNQYLRETLRTRTMEHEEETEWKRRRLELDNRLISMQENMIEMQKEATRMQHETMKIMAALIEKVQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WTG9</accession>
    <name>A0A6G0WTG9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_011895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000151">
        <property type="protein sequence ID" value="KAF0730787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WTG9"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0730787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="188" mass="20188" checksum="AE01846FE3617F0C" modified="2020-08-12" version="1">MTAARNVITSTDVIIASSLWLCWDLPLSGLEMDGQEAVFRLCGDSSSSTTTVACSGGCGRLPAGWTACYWPFDATVIACQQEEASLASGGAQSTHRETFPRRKPCSSLSSISFFVERGHDAAEHIYSSFTTIVMLILGFVSVEALRGVVVEASWLRLSSWSQLSHLAAACRVFHDVPAGTDVFSLLIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WTV7</accession>
    <name>A0A6G0WTV7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_011763</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000149">
        <property type="protein sequence ID" value="KAF0730881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WTV7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004373"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016638"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050367">
        <property type="entry name" value="APC_superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42770">
        <property type="entry name" value="AMINO ACID TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42770:SF7">
        <property type="entry name" value="MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0730881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="446" mass="48781" checksum="7445799352181828" modified="2020-08-12" version="1">MGESPVAKSSNKYVVSSKHIWAIGFTMIINGQFFFWNGGVVVGSVGFGLVILISGLAFLCLALSMAEMSSMLPFAGGVYGLSRCAIGFQAGFILGCSEVLDYLVNAAMARVDTVSTFLGNFQMWFSQLPNGIWIYTGIEGLNTLCNEVHDPKSSIPRGQVACMVTVFVTAISIYIVALGLPPGFDALPSVFAIFNGCFDQLFNISDDTATLLSLPSIWVGIPGLVLCSSNIIASMSESKLLPIDLHERHATFGTPARALVFTCSLTLVFCFIMFYSIPAWIALPAMSSLLTCLVYISQCVGYISLKRRFRTMPRSFYSPLGVPGAVFSAFDTNVECLVLASSVILLLSLYYQFYAKSRQTISDDERKLLFFVHIANNNDAKQRHSRPSFMKRLLKYGSFTSLNKSSSKAQPTSVSAKVYIANSKQSTRGSISKAMKDRNTIHRINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WVH4</accession>
    <name>A0A6G0WVH4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_011151</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000141">
        <property type="protein sequence ID" value="KAF0731526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WVH4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014043"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0731526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="68" mass="7673" checksum="7EA290223A16E8D5" modified="2020-08-12" version="1">MLSSHHSALKKVVDERTAALSVFFKELTYIQALMGETPQRPPEPLNLTSSGFDAVKEDLRVKKIEQMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WVQ0</accession>
    <name>A0A6G0WVQ0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_011184</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000141">
        <property type="protein sequence ID" value="KAF0731562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WVQ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005511"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052384">
        <property type="entry name" value="TMTC_O-mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44216">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE TMTC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44216:SF3">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE TMTC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0731562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="290" mass="32615" checksum="9A6FA5A4C2885BE5" modified="2020-08-12" version="1">MAKLQGLAARIKARKSTPLLAKYGVPIALLLLAIGVCLLPESIDLWPTTEVEPSLKTPGGWMRDVVDEKRRGDLLFDAEQFEPALEFYIRAMNLAVKHHKENSATPDESKLMRSYLSNCLAMTYVQLGKDAEATTWYKRGLEINGDHLELLYNYANLCSRTEKWVAAEGYYRKVLKLKPSFQPAMVSLAFVLQQQGALEDSRTLLLDSWDLSKDDPEVAAQLGWQYMAESDSLKALEWFDVAVKMGHEDAKKQRDDIMAAWVKTQEMMAASSQSIGNHESDTMPLADPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WWG0</accession>
    <name>A0A6G0WWG0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar protein sorting-associated protein 54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_010843</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000138">
        <property type="protein sequence ID" value="KAF0731889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WWG0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002992"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039745">
        <property type="entry name" value="Vps54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012501">
        <property type="entry name" value="Vps54_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019515">
        <property type="entry name" value="VPS54_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07928">
        <property type="entry name" value="Vps54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10475">
        <property type="entry name" value="Vps54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 54 N-terminal" evidence="10">
        <location>
            <begin position="378"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 54 C-terminal" evidence="9">
        <location>
            <begin position="880"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="702"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="18"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="99"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="122"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0731889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1127" mass="123077" checksum="C1CF156087F697CE" modified="2020-08-12" version="1">MKATTGFLSSFMPGKKATPSTPTPSERSSNPTSPTSTTTNSNPFAASCATHSTPGNPFATSSNSTVSRGSHPTSSSSANPFASSIQTTPSGESSSRTNSGHASSTGSSGSLKSVPPVAPTNPFATSNSTANARNLTIDTTALPSSAPRPPRSTDSGGSQSNSFTKPRPPLSTGSSMRGMMSSATSFASSMLPSTPSSVSKMTSVITSTSASVIMAPVKGLGVVTSAAGSAVSTAADLLMPADFPKLFAQSKVDISGFYSPDMDDNAGVAVSDEAREFLSVSGHNLHSVLTNPRSGNWGDALMDALTLPGEQTEAALTAILSLPSISRRDFDGYMKALGESSAMYMKNHERPVREQLASSNVPSVQAANEDVQLCFQAVPALYFKPDFDITNPEVFDQVMAMGSIQESQEKLSGYLDRVEVSLLRQVSSRSDRFFEASSSQGEMKKRVTQACDQVKHLRTTMDRLRNSLADKSLAILQLHRKQKRLVELHDLMVQIEEMKHTESSVEALVHGHDYTGALDVIDAALKTIHQMAGIHCVRSLGEKLQTYRSFIGVQMSNRFVSVVTAPEWAFEPGPAPTNPHALQSLQLKQKETREEMKQLMDALFRLEIVPDVMGKYRTQITEEIKIVVKTVVSETIASSSASKKEGETDVSSQLRALSSEEFLNCVQMIFEHLLLVLQRAMSVQTMLAETFDIPVVAAETKEQTEGAAPTATEWTPDDSTNDKLGEWQEKKKAAKIVKEVEDAIRKTCEFSQRSVSNLFGVRKEVQANYTMPQLRSLYDATMGFVVKLETSTGKTDYTLRGALFNQLKLFLEKYHQSQSSKLVSTLNHELWKNADISATRHAALVDLATGKGVSLVLSHDQTVVAETAAPLKQLTLPPSTSFRVVWSVLLAMEIVMNYLSLAVNFPVLATDVLQRTIEILRLYNSRTTQLVLGAGAMQVAHLKSISAKHLGLASQSLEVIIAYIPHIKFQLAALLTQRQKLLLDELDKVLQDYVEHNDKIFAKFISIVEDQIMKKFLETVETDVNYDDATLLIPSAPLKGISQNTVKLYQVLSPVLPPLQMQVIFSRVFDMLEHKMPACFKAVQPKTKAGKQRLIDDIVAFVESFHELKDVVFRGDQLVQYFKTSYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WWW2</accession>
    <name>A0A6G0WWW2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cation-transporting P-type ATPase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ae201684_010918</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000138">
        <property type="protein sequence ID" value="KAF0731967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009336"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005391">
        <property type="term" value="F:P-type sodium:potassium-exchanging transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000003">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000083">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000095">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050510">
        <property type="entry name" value="Cation_transp_ATPase_P-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294:SF21">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="320"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="827"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="853"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="900"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1224"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1256"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1288"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="13">
        <location>
            <begin position="46"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="686"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF0731967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1340" mass="147170" checksum="6C40C8BDCA2890EC" modified="2020-08-12" version="1">MSSNNRRSSAEIVAVSTEMRHRQAMRKKGKGKSGKDDDNKRELEMDEHKKSVPELCADLTTSVTLGMSSSDADARREVDGLNKLTPPKATPEIVKIFRELTGFFSLLLWAAGILCEVCYALQGSTDNLYLGIVLFAVVIITGAFSYFQNRKSSSLMESFKNMMPTMSTVIRDGKSQKIDATLLVRGDIVVIKGGDKVPADLRIVECSDDLTVDNSALTGEPEPLKRAVDCTHDSPLETKNMCFFGTFIPQGSGKGIIVRTGDRTVMGRIAKLATGTKKEKTPIAKEIDHFVHIITGVAIITGIGFLIIGFIIGTDTITNIVFMIGVIVANVPEGLLATVTVCLSLAAARMAKKSVLVKNLEGVETLGSTSCICSDKTGTLTQNIMTVANVVYDNQIWDAECSLTPTPSYKLTDASFQRLQRCATLCNNAVFDEESKFHKVVQGSGANLQIVRGAPIAFSEIVVSSDGVRCPKVLWETIGDASESAMIKFCQDKRDIIEYRQANTKIKEIPFNSRNKYQLSIHKQDNDETKPMLLAMKGAPERIIARCGKVLINGQIEDMTPEKIAEIEGLQLALSKKGMRVLGFAEKELDLATYPHGYDFNTDNCNFPLGEKDVDYDAVPKPDKKIEEPLCFIGLMALIDPPRQEVPIAVAKCKTAGIKVIMVTGDHPVTAKAIAHKVGILWGPTKDDIDEENKERGLNPGDPGYRNPDSAPAIVVPGWTISVDTPEEEWDRILDHPQCVFARTSPQQKLIIVENCQRRGEIVAVTGDGVNDSPALKKADIGIAMGIMGSEVSKEAADMILLDDNFASIVVGVEEGRKVFDNLKKSICYALAVNIPELVPFLVYILIALPCPLTTVLMLLICLGTDMIPAISMAYEDSENDIMLRAPRRPSIDRLVTKKLVFWAYVHIGMIQAFAGHVVYFTVLNDYGYPAVLTPGLGQIDSFGKQVLWCTTTGGQYCTPGGKYKDSNGALEPLGLSSAPVCGSSYDDTIPANGGIYDAKVFYKQGDEGVVDDCVFPYANYQGSTNKPSNYNRFDPTTYGDFTNGKPMITVQSMEALWNAGYRPYYPYRGRRSVFFNKNWFKWDTSNEDVDGFSSKLEDVAVLLFQPIGTFSIVDSSKTVGDSSVMTSSRPKTIQNGATATLTDASSKLTSSTIKLSNDILFSNAVAGFGIKNTNGTAVCNSPESCLLDYRSGFAYKDASSGKIYSNVMSRMIAMNALLHSQTAYFVGIVIMQWSNVLICKTRFLSIRSQGLHNQVLMFGLGFEFLICALICYSSGFQTVFKTKTIRLNHWFIAMPFAMFLFVYDEMRKYMIRSTSTVQVDPDSGKSVRTPGWVERNSYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WXF3</accession>
    <name>A0A6G0WXF3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dynein assembly factor 1, axonemal homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_010827</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000137">
        <property type="protein sequence ID" value="KAF0732178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WXF3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002023"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002024"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050836">
        <property type="entry name" value="SDS22/Internalin_LRR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652:SF3">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0732178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="432" mass="47749" checksum="062B8A9049637196" modified="2020-08-12" version="1">MLNQIDYNDAGGVDESEVRMALKLCNGGDEPAKKDVEYFVNQLGYMIWHTGNDFTTRMLHTRASLEHLLLSKFAKSPSKQDLMGIPPWSTLAQIRHAELVTLPKESADENTFGEDNLSNNDFGSPVQVMWQSLSTTSYSDDHFRSSANTKCLCTSDENGDSSLQGGDDESSTKMKATIEDLIEIVIDPASNSILSETTELPSTISEDPTTSNDKVATNEVGFTTVVEEVPLNTDAINLLVEEANGESCCIDKESVGTNAAIPCNHEPSQNPCIVAEVKVHLEQRTVVKLQHKSLQAGEALDSTFDYIQFGNVVALILSDNCLTSMECFQLINPLHVLRVLDLSKNQLTNISPAHSLGIRNLEVLDLSHNQFKEISGIEHLTKLRALSYAGNSIRTIKNLEKLEYLEILNVSSNQIMVAQSLRMLRMNKVSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WXM1</accession>
    <name>A0A6G0WXM1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_010575</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000135">
        <property type="protein sequence ID" value="KAF0732284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WXM1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000318"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="5"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="105"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="201"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0732284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="308" mass="33870" checksum="52CC9EB18131A9E1" modified="2020-08-12" version="1">MEHHDVLPVRLTASAIAASTAELATLPFDCSKVRMQTQGMAKLTHVQFNGGVIDTMSKIVRHEGMGALWNGARPAVVRQVAFYSVSVFLYAPLRDSRLVGASDSTPYVQKILAGGISGAIGIALANPLDVIKVKMQNDRSRTRLYHSIGEACQQLYRTEGMHGFLRGILPNMQRCFIVNGMEFGTYDQCKTALIDTGVVSDSFRATVGASLLAGFAGALASSPLDVIKTRLMAQRHELEVQQSGHHAPRQLYNGVLDCGRAIYQQQGIRAFYRGFTAYYLREAPWCCIFFVSYELARNAITRKALLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WXU3</accession>
    <name>A0A6G0WXU3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rubisco LSMT substrate-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_010495</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000134">
        <property type="protein sequence ID" value="KAF0732386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WXU3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014146"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10527">
        <property type="entry name" value="SET_LSMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1420.10">
        <property type="entry name" value="Rubisco LSMT, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015353">
        <property type="entry name" value="Rubisco_LSMT_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036464">
        <property type="entry name" value="Rubisco_LSMT_subst-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF137">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09273">
        <property type="entry name" value="Rubis-subs-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81822">
        <property type="entry name" value="RuBisCo LSMT C-terminal, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rubisco LSMT substrate-binding" evidence="4">
        <location>
            <begin position="278"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0732386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="429" mass="48539" checksum="ABF03FBCC0B895C4" modified="2020-08-12" version="1">MDDDLFIGYNAWASEALGISVNADLVYEAKSEGGDRGVYIADDIMPQTTVLSIPSESLLNVHSIASSPLQNFLSLPLREDDLLAWFLIYENFLNPQSKWKRHLDVLPKKYHNILYFTTKEIDLLAGCNIYHIALQLQQQVDADFAELQQTLVPDTLRLLSGEFSTEVLLTAFSIENYKWALSVIWSRFVSVALDEDNLAKSMVPVFDMFNHDPLAQMTHGFDPSTNSFVLRSHLHWSSGSQVFINYGALPNHKLLTLYGFVLASNPFDSVELWAPMGEDAPYYNRKIKLMEGHGLAEHAQAPFELHGDSVNDDLLAYLRIQRLDVADLSSVVVETPNFAFEPVHDENEKDTLTALIYALQQMLEAFPTSVEEDEEALSNAQDSDDESHELMALRLRFSDKRILHAQIEMLQEMLLPVLARLNEAGQDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WY06</accession>
    <name>A0A6G0WY06_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_010527</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000134">
        <property type="protein sequence ID" value="KAF0732418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WY06"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010754"/>
    <dbReference type="OrthoDB" id="79842at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="54"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0732418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="125" mass="14919" checksum="E1A2E23F7E97CA1D" modified="2020-08-12" version="1">MDSKTQLSFILHTNDKRTSPTHREATSHERTSPKQRSDSPLSPERKSTELKLIYNRVRQRNLRHREKIERLHLERQVKDLELQLRLLQAKHRRGKIREMLLERQNSPLRMPEVLPPLTETESSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WYT6</accession>
    <name>A0A6G0WYT6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartokinase</fullName>
            <ecNumber evidence="7">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_010107</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-aspartate + ATP = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the aspartokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="7"/>
    <dbReference type="EMBL" id="VJMJ01000128">
        <property type="protein sequence ID" value="KAF0732775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WYT6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003559"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00015"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00461"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009090">
        <property type="term" value="P:homoserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04243">
        <property type="entry name" value="AAK_AK-HSDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054352">
        <property type="entry name" value="ACT_Aspartokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005260">
        <property type="entry name" value="Asp_kin_monofn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499">
        <property type="entry name" value="ASPARTATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499:SF59">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22468">
        <property type="entry name" value="ACT_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000726">
        <property type="entry name" value="Asp_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aspartate/glutamate/uridylate kinase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Aspartokinase ACT" evidence="10">
        <location>
            <begin position="422"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0732775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="515" mass="56066" checksum="A0EDBF46FD3BB42C" modified="2020-08-12" version="1">MWVVLKFGGTSVSTAQRWQCICNRVAEILQETANTRVWVVISALSQVTNRLTQALDDAITGTNHLDRYFEIFDQHIELAREHNLITANDAMQLCTDERTAASHPPSVLEPLVQEFHNLRRVLDGIRLTEEASPRLKARILAFGELLSTHLGLEIMKQANLGSVVRVDARQLLLSDPTISSEMDRYLEANVQPSIDADGRLEDASAGASVVLTQGFIAGVSTATGIETCVLGRGGSDTSGALFAAALQASRYEIWTDVHGMYTSDPRYVPNSRLLRKLDYREAQELAAMGAKVLHPRCIGPAHWANVPVEIRNTNDPSGEKTVIGHMEDSGSPKIMAVVRRMNMTLVTITAYGMCGTSGFLSKVFLPFETLGISVDLIATSQFSVSVTLDHIPGGVNGTSFGALVQALERLGAVAVVEACATVSIVGRHLRTSLGELGHLFELLEGTEVLLLSESAEDLNLSFVVRESDADPLVQKMHAALFPGDELVLPMRRSISRDELLGSSWSSLRSPTSQFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WYV9</accession>
    <name>A0A6G0WYV9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_010235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000129">
        <property type="protein sequence ID" value="KAF0732703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WYV9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012977"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36960">
        <property type="entry name" value="SI:DKEY-32E6.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36960:SF1">
        <property type="entry name" value="SI:DKEY-32E6.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0732703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="384" mass="42974" checksum="12CC7BDAE301048E" modified="2020-08-12" version="1">MMKKLVLHFDLNRTILMSDVAGGRSMENTLNYLLAECTYGRVLENEWVCVSKEPSLAPPAPSLITYKAFVDTLYPYKSMHGATNALDEVKAFNKAQKKKRTALQSAFTSGPGRPISESYDRVLSSLYFPEGSTREAAKAAAATLPACGLKEAWSEGRYYILPSFLHLLFHIEHQRASVDLKVVFRTFGEDIVEVAKEIDFLVEGRHPLFPGKALAKAMRLEPPFATFYRDGFDASGTALALNTLTKVPFNASNTTATPNEFYATASPPVTVIRGFPSIQQEVNELLSSRPVIALRDYWEWWSTHAEHAEYGKLLLVDPALPAVFFDDHIEEHEAHIVDVRNAATGTVVPFEEAKAKYLRRVEPFYAITDASYYIRHVQAIVDCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X0L5</accession>
    <name>A0A6G0X0L5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_009576</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000122">
        <property type="protein sequence ID" value="KAF0733326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X0L5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013167"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013168"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000085">
        <property type="entry name" value="Dihydroflavonol reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="10"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0733326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="314" mass="34220" checksum="7F71026D42BE4508" modified="2020-08-12" version="1">MSASNASTVVCVTGGTGFVGSHVVKALLDRGYTVNTTVRNMNDEKKLAHLKSLPGATERLRFFQADLVEEGSFDEAIKGTTYVLHTASPFFIGNATRENILDPAVDGTLTCMAAVSFNMGTVPSTHVYTEADWSREDLLEQHSIWYPLGKTIAERTAHEFVEKETPGFSVVALNPTWIFGPLLQPTLNESSQQISRFFTGDLKKIPNAFKSGVDVRDLAIAHVAAFEKPAANGRYVLIGWQATEAEICARIKELYPSAPIATEVDGDGKTPERMLFDSSKAVKDLGLKFTQMAETIADTCQSLVQHGFVQTSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X0S5</accession>
    <name>A0A6G0X0S5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_009729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000122">
        <property type="protein sequence ID" value="KAF0733489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X0S5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017079"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="106"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0733489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="423" mass="48375" checksum="769D29A5E8131D92" modified="2020-08-12" version="1">MDKLFNVDNSKHCVEFEIYIVSRIVKAMNPGDTETSFISFWDDLIRNVLNFMLSDVGKSERNSSRSASTEPKRPDYLFIVDSVCVFRGEGKVPGDSIETPRRELVDKLVWSYGDVPYLFGYTAVGYDVRLYALTHVDNVTKAIELAVYNLAHLEGRFRLLLAILNIVRLLRCLAKMCPDSARGEYRVLKRDFGVKLLLDPLYVVKSFPKEAFEVARSHVEAVYTVLREQKVPNVDSLVRVDKKHSEFIFRPRGQARKPANLEELFHALTNVLQALVKLHTVSWMHRDIRWSNVIMNHNDNSWFLIDFMDAAPCPQSSPSGNHLSKAEHAPEIFIDGGSHKTAVDIWSVGFLIGTCEDNVCQSWYDLGGKRTQFHRELMDADPSKRPTAAAALDRLGHFYQEYVGQQVLPKETQDPRKKKQRPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X1U9</accession>
    <name>A0A6G0X1U9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_009347</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDC6/cdc18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000119">
        <property type="protein sequence ID" value="KAF0733779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009793"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049945">
        <property type="entry name" value="AAA_22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF26">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="974"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="609"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="738"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="823"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="905"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="422"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="612"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="742"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="825"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="914"/>
            <end position="929"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0733779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1313" mass="148593" checksum="CB624B68C45C9CD3" modified="2020-08-12" version="1">MTSEWASMLRMARTADGISNGAKWPVLVFQSYQAARDWLVDVTPLEKLKPVLDVEDCVLFYFGRCDRRKTKPEEVLHLAVMPEHDAEMDVYQNAQTKISDPLLALAMKQAREFAEAPSKLGAMELLVQFIIQDSSYVLELDEEENSVAHRRKTEQEEDSPELVWSKLFEALWEILVADGWSLASFGQEILYVLPDVDYFNFEVDSTVFKSKRKTLLKAIEFYAETENATASAIWENMWTMMEELKQGKTIVMKNTMFYVTPIIEKFELLKRGENLFATKKDAVVQFSRRMQIPTPQKPKAVPAIAPQLIHVPHSAQNEITIFEEELKTKSRPKVVKRKQPLQLTDRTHSHPVGLRRRLKSQYPWGLILDVLTKDFGWSYKPGRFGFEFSDAVGTKFESEENAMEFVASTDLLGKVESILKERGAPTPEQEKENGSKANRYAQESDEDYATMLIGNTKEKSKASRTIVKDSGMDADDLPIKKKKVLKPKKRLSYSSPGKSKTQSSQIKFGQIERVLKVQGWKWVSGPMGFIYCKPHVVIAQKGRRFSGKENEDYFMSKENFEVYVRSNQELMKLIRNAISGEHEDVFEMPSDEEVVIKQKKSKVKKVIKESVVEENSEEENEDSSANSGNENESIRNTNTGRIIKKKTKGEIDAISCRPVPTLEVKFANVYKVLQARGWKHRPGMFGYDYFRPGVPKEVKKVINETYYHNEADVEMHLKKTGEWQEIVRSLQRRHTAAFNGFSSPSSSEASPNPKSKSQPPSPATSPFSKKWSQLKANGWTAKMGNSNGENQLYCSPSGDIFTKQELETCEVEKLLLLNPDSPIVEVHDSSDDDEPNQHHDEYMADPVSDKEETKDEEDDSHTIAVQETPDVHVSQNSTAPPSFLSPDETTLSKTDKVVARNVQQDFTPSPSENSSKPTQKSPPQSPAKKTQMDLEIERVLQSLAPSYPLTSLLHRNKEWLELTQFVDACIHRDQRKSVFLSGTPGTGKSALVRLMEQYVENSWAKASKSSKMQFVNLNAMTLGDAASIFKAIASQVTNTDYSSSEQAISALDVAFKSNDSVTFLILDEIDILLRGKGESDLYRLFEWAHHPESSMVFIGIANSIDMTERYLPLLRQRDCKPLSVVFQPYNYDAILDILKQRICEDTLLDKPIFDFMSIAFLARKVASTSGDIRTALNLCRCCLLQKQIQSVASPVLLNDMVNAVKKGLEAPGISLLQTLPRMAQLVVYAASKVQGVRDGVYNINTVYDKYCDLVRKSMSLSQLVTLGEFNQKLDTLEAQGIVTLHAKKGVFKLFVSSAESEKYFASESFFKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X2D5</accession>
    <name>A0A6G0X2D5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_009230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000118">
        <property type="protein sequence ID" value="KAF0734060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X2D5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011225"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="2">
        <location>
            <begin position="7"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0734060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="633" mass="67908" checksum="5E2B7970BEAA918E" modified="2020-08-12" version="1">MDQDGVYKLAIVGGGPAGVGVLVRAARLGYLPQLLSPAASKGVVLIHGGPVDNLGCGNLGEYIINSNTFAKSLVSSVLEEKPDLDPPESIHGTFLEELTQHAAAKRLMDAGNASIGLPELGKFLAALGSLARLEMLKYGATSTCLVNTMAVSVARVGEHCEITIKSVGGGDERVILADRVLLATGGHQAMPPELSNYRSKAFLSDYVLRESGRSELSAVLAKAKEKKVCIVGGSHSAFSVAWVLLHKMQKENAFGPKDITMLHRGPIRCYYATKKEAEADGVVVEKTDKCGSVNTFTGLREDAKALYHAITAGREPRVRLFQLKKQPCAVQTHAYEAATAIVWCCGYGTNTIPVTANGAELPLRRNGNGGALELDLKGHLMLSTGESIPWLLGIGVGFSLRAAFDEMRSETRADGVTVYHRRGATLVLAAIFGTQIYGTDCTTFEQMVEKCERRRKEERAPIQAAFSSNKESSKGPASTTREPSIVKRLSSAKLTDEPSYPPASTPTRIRLKPPEKALASQTKPRQLSLRVKPASKECEDAAPSIVRSLVATRQDDGKAMRRRTSLDDHALHLKIEPRSATSQAIGAQSCGKPKAVAGGAKDAIQRIRLERCSRVNGRPNQEDGVTAIPVVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X3F5</accession>
    <name>A0A6G0X3F5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_008890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000114">
        <property type="protein sequence ID" value="KAF0734430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X3F5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020569"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPRY" evidence="1">
        <location>
            <begin position="221"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0734430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="364" mass="39369" checksum="9455D70DFC674590" modified="2020-08-12" version="1">MLVASPVAPPPWNPSRSSRGLKTFVLLDKTRSSMTTTTTLYASYKAVLTQTPLHFDLLARVDPLQSNGACSTNNRRRRQDGSTRQDEIAASVFEVAFAFLDVDELSACVLVSKSTKTIATRAHLWLAIYNRAWRANGQTLPRPWMQLTYHQLVVLVQSRLHLSRLELSTRGRVLELPRGLVQVANTSVMRTFANGAVESIRGKTPLPLASCGLALGVEVAYYEVAMKSSGSVGLAMLTSRDYGYAKESHVGSHAGSIGFHGFDGGLYEHLGASSGHESDGKLVNQGPTWANNCTLGCGIVHGSMSTVFFTLNGELVASTSVEHPLARQLALAVSLEAYGDECVVNLGTAPFVFDLEAYCLSCNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X3P1</accession>
    <name>A0A6G0X3P1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_008792</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000111">
        <property type="protein sequence ID" value="KAF0734550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X3P1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000548"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0734550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="387" mass="44366" checksum="45D917ED7C264F7A" modified="2020-08-12" version="1">MNYTHFIHRPATTIRIYWVSLGQAAAFRLTELTVAYTENKGVHSRSLKRLRAFLSPRASAIAWIVTTILWNTPFIILVTIQSNKLDYCPSGQGREVLICYSTEFCILFLLSIILSCHLSHDLDNFNIGGSFRTSSRVIAFLFCFTMPALYYSDTDVVQEYALDLYACLLTAHAFLWIHIVQPVWRSMDYDPAHDAQVLHGTAAVLDAYLHTPEGFDTFCEFAKLEFMYECVVAWKAIVAYRLDTEDHMTTYEIYEQHLVEHAPLSVQSALPESVWKRYQIAFASTSKYTIRPEEIHNDSTYYDVLFDAITAKLLRETLPHFQNHTLGAKWTHFVMAYRATVALNQVLDDVPSEFDSSVKRGIYIGTTKRMLPIQSEESMVEISEGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X4S2</accession>
    <name>A0A6G0X4S2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WRKY19-like zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_008501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000103">
        <property type="protein sequence ID" value="KAF0734837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X4S2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010378"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056866">
        <property type="entry name" value="Znf_WRKY19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827:SF1">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24906">
        <property type="entry name" value="Zf_WRKY19"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WRKY19-like zinc finger" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="WRKY19-like zinc finger" evidence="1">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="WRKY19-like zinc finger" evidence="1">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="WRKY19-like zinc finger" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0734837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="157" mass="17307" checksum="10332EAB1CD64720" modified="2020-08-12" version="1">MLHYAFRRLDLMTDKLTIAFLLNDDATDAVLPWTRKCKTDGCFNYAASKGLCIRHGGGKRCGVTGCPAGAKNYGLCWRHGGSKTCIAEGCTKRSKSYGRCWSHGGVKRCAFPDCTKMSLTNGRCWGHGGGKRCLVADCKKPAIARYNQRCARHRLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X535</accession>
    <name>A0A6G0X535_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_008441</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000102">
        <property type="protein sequence ID" value="KAF0734966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X535"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000176"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF8">
        <property type="entry name" value="ESTRADIOL 17-BETA-DEHYDROGENASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0734966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="255" mass="27112" checksum="E9EF7952494CF950" modified="2020-08-12" version="1">MAQQPKRAKSENDVTPVAVVTGGSKGIGEACVEKFLSKGYDVFNLDIAPSKVGNFVQCDVGRVSEVEAAIASIVAQTGRIDALVANAGVYFSASIEETSEEELDRIISINIKGAYAAVRSVLPTMKEQKKGSIVIMSSDQAFVGKKNAFAYNLSKCALASMARTTALDYASFNIRSNAVCPGTIDTPLYRREINAWAESSGTPVEQIHENMGSFQPLNRVGLPSEVANLVAFLASDEASFITGSLHSVDGGYVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X584</accession>
    <name>A0A6G0X584_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_008442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000102">
        <property type="protein sequence ID" value="KAF0734967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X584"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000177"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="54"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0734967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="388" mass="44333" checksum="DAAFBF37D2887481" modified="2020-08-12" version="1">MTDEAKIQWTPDDNDGLPMLFAVDDQLHDELTYVYNLLAEPVEQPKAPNPNTSRARQLREMDKLRQEIADLKVQLRQAKRQYVASMVPMSVWEGAARQQRLEKERAIQENEKLRSQVHEYATFIELLEASMHKKPRLSLDADLASPTWQEYKLAAHAALRVAAIHAIADREYRRLHYIMTNAGLHDYTGQDFLRVHPLIRDDGKVVIEAVYHLTVPAPFHPVGKALWDVVNGTHGPDLPGEERMDDFTVYRTLRLANTTGEVHSNFVRKYFPEDDRDIVLWRSVLNDELIPQMDQGAVNDESGWVVVRAKDAHTCYIQTVLHMVDSQGTCDRLGAAEILIDCWSSLDTNTLLPRGQEPQPMQTFMAIGRRIELAAKRAIDAVVSKYHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X587</accession>
    <name>A0A6G0X587_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_008323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000101">
        <property type="protein sequence ID" value="KAF0735111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X587"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001001"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0735111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="546" mass="61465" checksum="C14F59E1AB84AE2E" modified="2020-08-12" version="1">MESIEAKLRLARYKNFDPFYEGLLRSPPSKLAMATGRLSIGAPSFPLSKAFQSTPKAAPTELAFATDTISTLLALQQLDGRWNMDDAFLHAMHGLVPPCPPGVGSTMWATACALAALRRHPADFERLDLPCSKALTQVDAQVFEWAKQALPHIPNAANTAPKLLTALEDAAPDVVLQRKTTQVDRLSQEIQRHVESSAANALQEGYAREFKPRNLPPEPFQVGDVVECCWRQAQRANNAPCGQAEWAPARIASVDDKNKVDVVYLGGRRERLFGVDAALVRRPNAVKKAPNEVLRDLDRTWLEPLPLQDELQRVQQVVRAKTPPPWHESTNIEKQTTRTRRSRPPRRQTNAVAAATNDFFRNNDGKPLPPAHEATIAAILAYEKCLAKVSPVLKQCSRLYRSSARSFRDRIHAFDAFTPVVLELVLATVDCIERVFSFEQSLQSSTVFAPFQWHGEPFLHSVAHHADSFASCKPLQDWYGTDFHFEMNPFLLTMPLHLKQDKIQLAVVAHSWWPENRYDAALRQQIDRAEQQLLEHLARLDPCNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X842</accession>
    <name>A0A6G0X842_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_007234</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X842"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004471"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="83"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="237"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0736211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="37463" checksum="4FFFECE4DEDAFAA5" modified="2020-08-12" version="1">MERKGQLSFILNEPPPLSAYALPRLDEYTRLPPLAKKRPLDALSPSETVKSTTASIAYSPVKKQLTKRSEKCPVPLGDGLFAKRGVAPKTPLDKRRYNRERQQNLRKQENLERQTLRHQAQELEREWERLSHQKRLRMSNSPLMPQSAASMHHLLNARVAGYTAFAQSIQEWVAKILQDVDADMEWLQSLEKMSDGSSSACTNAQPLVYSALDVDLSGLPPSSRKRMYNRLRQRLYRQRELREVELLHEQVRELSEQVELWKTNPRAAAAQMGEASEKLRTALRHNDQLKARVQQYVQFAAQVHEWVRTSSSQLEDDFPLVASLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X8B7</accession>
    <name>A0A6G0X8B7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_007249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X8B7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002525"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="2"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0736227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="148" mass="16890" checksum="D9F4B40CA0B60950" modified="2020-08-12" version="1">MVWGAINFNGVGALRFCDGKMKSEDYKCLLDDELGDNAAKFGLPLDFVFQLDKAPIHKTALVSKFLDENMIETLDHPPQGPDLNPIKHVWEFISRRLRELHATSVESLKARIMTIWDQIPQDYIQKLILSMPKRMEDVILAKGGSTKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X8H2</accession>
    <name>A0A6G0X8H2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_007350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X8H2"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0736330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="145" mass="16870" checksum="985A97E0A27CBB5A" modified="2020-08-12" version="1">MAMQKRLDGWRRRIQTRISQEGMLHETAERTGGGKTSIPRRSGGPKMLAEEMFDPVSATYPNGPRPRWTILSITTSFHVKKASWRRTAAAPSSWSRLPERVVDQKCKIRGRFPRRFGIILCQFRCRRGRHGFFLTLNAKRTRRQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X8H7</accession>
    <name>A0A6G0X8H7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_007308</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X8H7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005054"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="122"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="77"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0736287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="226" mass="25822" checksum="E4374A4365947EB7" modified="2020-08-12" version="1">MHSPSASGASAFVYRGSSSDRVGQAFRGLDGQFYVKLYAAKSTGGCRHCSVTCRITRRGCSLDPAHNREGRKVYDVDEDDCDEWPPREKSPRRSPSQSSIRSFEPVAEAVSDLEQQRREVASTLMLNAVPDEVTRSELLRLFSKHFGAVYMVRLPHDFDSGVRRGFGFVEYFDEQAVLRTMRGRRRLSVAVNGRRITIQRAKYPRSTPEEMHARNAHRRQRLLRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X9K2</accession>
    <name>A0A6G0X9K2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Macro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_007101</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000088">
        <property type="protein sequence ID" value="KAF0736651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X9K2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016960"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35609">
        <property type="entry name" value="MACRO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35609:SF1">
        <property type="entry name" value="MACRO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0736651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="39006" checksum="A16FB5ED0C6A0790" modified="2020-08-12" version="1">MLPRRHGRTDWFQALFDFREREYDYADFQDLFEVVQKTTLRSKMNDKTYQVGTFECLSLEDLRDAGAATAVAGQSTLRHIAAGDVFLMHCDPDNKHALFQAASQFNCLEFVSPNRVPENGVTCYANDMTQGPACAIAAGPATVYRNYFAEVGGQIGQTRDNQINNLDTIEDLIDNETHNFFEVYNGYTDSTKGQLSPLNAMIEDEAMRAKLAKALKIGVHWDVEVPFVDRFTAADNSDQIVSQAFCSAISVGYSSAPASAWAPFAQLVLDASYEATLWAAVVNYHKTGCNKVFLTALGGGVFGNRSEWIVDAIAKAVRAVANCGLDIVLVHYRRVDPVMQDRVARALRGNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X9U9</accession>
    <name>A0A6G0X9U9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_007187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000088">
        <property type="protein sequence ID" value="KAF0736741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X9U9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006448"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.239.10">
        <property type="entry name" value="Elicitin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036470">
        <property type="entry name" value="Elicitin_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026276116" description="Secreted protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0736741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="108" mass="11300" checksum="7E351F1A3DFF5C48" modified="2020-08-12" version="1">MKTSSLILACVAANAARADDSTACLAKFTQVLQAGIVSTDVQQCVKDTGVSPTSPNLTEADLQKALAAPSCLKWWAGVVAQVKAIKPLGISPTRTESRHSTRHHSTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XAB6</accession>
    <name>A0A6G0XAB6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_006807</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000085">
        <property type="protein sequence ID" value="KAF0736996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XAB6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015645"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="6">
        <location>
            <begin position="149"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0736996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="243" mass="27677" checksum="1BDAE0934E44EA14" modified="2020-08-12" version="1">MEEIYVKYIGPLQRWLMFDMLGGPRPLPMRYLVNCQKGSTALFVLSLMIYFDNWSWGAYLYLANHGTYGIIWLLKDMTVPDPAWDVYITIPSTLSSGIGLTLYWAAGYIVVAHRVQVSPSLGALCVALNTLGSTLMIATDTQKYFTLKYKKGLITDGWLRWCRNTNYLGEMMIYLSFALLANHWIPYAWLAFIWSFVFMSNMINKDISLRKKDGGSVYVERSGFLVPNFAGWAANLLSPAPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XAC2</accession>
    <name>A0A6G0XAC2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_006860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000085">
        <property type="protein sequence ID" value="KAF0737053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XAC2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008453"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="502"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0737053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="795" mass="85843" checksum="80768A0B971FA23C" modified="2020-08-12" version="1">MLTRSASKSADSNATTAASSHGGDTMSPPVAILSSGDDPASSDDESQSRSEAVDVQSMDGMRSTEDSGDGANDDPGEDGDMGSSDPPSVSSKSTESAPPSQESIDTAAAASSRAEPAKKSSAQEGDEQTQPITSNQDQNVGQDGLSSSETANVSAGVTASTETVTNNNQAEAPQPPTFASATRGLRDRPVIRAESTLPKSELILEILEEFKKPANERRSVLDLFDNATPYPIKTAQDRVFVDSGHALNDNSVEAIMSSIYSSRQSPVVAPLLNDIVQVSKLAKGGLLLSVTTSVVAVSLGGQKLTIMGKKYPIPERVTHPLDAFVYMDVVGLRDTGVSVLPQLLLGVWWPNNEWRVYFLADQVPNQLRLNGVAANQLRLQKHFYPVYFKNVKPTPIVKGEGNKSSLCLDLDSKRAREGTSDDDDEEENQPHPPQNPANQQPPTTGKSDKKPKRAKKQKASPHTPSPPAPEDPPHPPTPAPPAPPASPATTAKPPVEVPKFVSSLQASISQSQSSDHRDPEPRAIDQEHHDPFEMEYSDAEDDGASVTRVDNVPFRPVSREDRQRCSKIQKTTTNLDTWATSNFYAPLASLEAGFGEHHWDENDATTSFLATFKRYDVSSLPPGESIHRLKVVDKVVCYDVNAMSLAQIQEFLERSAIDSAAASTPEHWALATQTEFIDIRRTTEASQADAVWAAISRSPLQANITWHKLASVDLDTLAAAARLHMWHRWVAANDCRIGRGFATTFNQLTTVNATQPHLDALLKCVSLIDAMGNVVDDPAQCCPNGLLFKRGVFDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XAM4</accession>
    <name>A0A6G0XAM4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ae201684_006888</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the RING-type zinc finger family. LOG2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000085">
        <property type="protein sequence ID" value="KAF0737084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XAM4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021135"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16789">
        <property type="entry name" value="mRING-HC-C3HC5_MGRN1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045195">
        <property type="entry name" value="LOG2-like_mRING_C3HC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045194">
        <property type="entry name" value="MGRN1/RNF157-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058981">
        <property type="entry name" value="MGRN1/RNF157-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22996">
        <property type="entry name" value="MAHOGUNIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22996:SF0">
        <property type="entry name" value="RE60872P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26192">
        <property type="entry name" value="RNF157-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0519">Myristate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="268"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF0737084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="331" mass="35835" checksum="734D310C04C5A6D4" modified="2020-08-12" version="1">MGNAGSIVSSNGAVARRSTAGNQPQLYGDPTTTATQGTQYTHAQMQALYMSRGRPDMGFIQNQLRTVLHAPPETQETTTVRNHVNLKKQSLKLHPLEKGEYQLQFSFDAAKPCTIALYFNALETIDDDGNSTFLNQKPELEFNSSAQTYPAELGQTFTSPILALTSWARSELVSAEDSTVFPLVVEIQVASSEASMKTQKQATFVAFPAGTDGKHKVQVVKQKVQVEGQTYELQEIYGMEGAACSAKAPKASAVAPDTTPDVVEGSECIICMCEPRNTTILPCRHLCICTECSEELKRPGSTCPICRGKVESMLQIRVNNAEEGGDAGSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XB80</accession>
    <name>A0A6G0XB80_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Anaphase-promoting complex subunit 4 WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_006539</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XB80"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021740"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854:SF1">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="14"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="281"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0737371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="34553" checksum="07043051830E1E2F" modified="2020-08-12" version="1">MATRNPPPTPMAVLRGHVAPINSVSFVADGERSQLLLSGSADGTLKVWDLSTRREKYSIQAHSKAGILHTATQGSSIISHGRDGMIKWWDMADGDMRESRSVACGSYTFTKTHVIDENLLLVPTEHAEMIALVDLRASDLHPSIVLNGSTLKAGMCMSLAFLPSSSTLGYPCVGFEGGPVSLFDMRSVTPLLSHSITTSSLLCMDVVSSTSTLLCGSSGPELFAAVMDPSTATATSQSIYHGKKDGFSAVSNRSDARIFATAGWDHHVRVFHRTFKPLATLKYHTESVYSVHFSPDNRLLASASKDHKIALWSIYPPSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XB83</accession>
    <name>A0A6G0XB83_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amino-acid N-acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_006583</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetyltransferase family. ArgA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.1" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XB83"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011197"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04237">
        <property type="entry name" value="AAK_NAGS-ABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01105">
        <property type="entry name" value="N_acetyl_glu_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033719">
        <property type="entry name" value="NAGS_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010167">
        <property type="entry name" value="NH2A_AcTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01890">
        <property type="entry name" value="N-Ac-Glu-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003641">
        <property type="entry name" value="PRK05279.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30602">
        <property type="entry name" value="AMINO-ACID ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30602:SF12">
        <property type="entry name" value="AMINO-ACID ACETYLTRANSFERASE NAGS1, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000423">
        <property type="entry name" value="ArgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="9">
        <location>
            <begin position="334"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0737419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="493" mass="54398" checksum="1D5D0B0DDC4D69D5" modified="2020-08-12" version="1">MKRFIRATTAIRQRSFTTMGIISDVPPECLKVAEPKDNTAPQLNSFNEMFRSMSPYINVHRGTKMVIHLCGDLIESPVFPTTMQDIALLSSFGIKIILVAGSRPQTDARLVNRDIPQIVERGYRVTDANVLSCAMEAAGSVRFRIESALGRGILNAPGDRQAINISSGNYVLAQPVGVRGGVDYKFSGEVRRVNVTKINAALNAGDIVLLSDIAYSASGEVFNIISEQIAAKCAVQMEADKLVFLHDGELLVDVRNNQTVHSLLIRQAQQYLELAALDPNVNSKFVSYLKHATKSCISGVKRSHLVSRHSDGALLQELFTRDGDGLMISKDMYEGVRMARSNDIPSIMRLIQPLLDADILVSRSQEQIESNVHTFTVVERDGAIIACCTLQPYEDNFAEMACVAVDPAYRKSGKGNALLGYVLRKASAQGVKKLFVLTTRTSHWFMERGFAPAEVADLPPTKRASINPNRQSKVYIIDISSKRVVEERELLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XB88</accession>
    <name>A0A6G0XB88_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_006572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XB88"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0737407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="111" mass="12830" checksum="7833BFA600AC4724" modified="2020-08-12" version="1">MGMRMTEQFLVEIPRNRRQRVVVVVPPIRSLGRRECKHFKGRCSSDRKTQRWFIARTFLQCFYLLGIPSRRRKSCTGGETDKESKANGERSTSHSPTDTNLDVNQEITLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XBY1</accession>
    <name>A0A6G0XBY1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_006323</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000083">
        <property type="protein sequence ID" value="KAF0737656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XBY1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005116"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0737656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="148" mass="16179" checksum="855371F1F057EC0C" modified="2020-08-12" version="1">MERSILQLSVHAKDKPPVIFVWKNVEGFVEAIQEARAKASAPEGMPLPPNPLALSGSVTIQKFKEAVLEYARVSCAAPRLGTSCLPCSLAQFGQVMCMLRTLDLNPWSQRVIAVGVPNSLPIACVYIPRPRSNTLRRATPHFVASLWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XCF3</accession>
    <name>A0A6G0XCF3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CBM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_005890</name>
        <name evidence="6" type="ORF">Ae201684_005891</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0737893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0737894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XCF3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013712"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014214"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033881781" description="CBM1 domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="4">
        <location>
            <begin position="288"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="187"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="187"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0737893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0737894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="326" mass="34840" checksum="4C693930B9EE3BE2" modified="2020-08-12" version="1">MITTTIATVFFALAATAHGHGNLVDPFPDFINPNSDISQFCGTLDGPKILPGSQYNTSPEDNTKAFTKNFKASLFKTLKDFVVGNPNKCGTCGLTKENGAKKTLNADGNVYWGHGQEGFTPSHEGPCELWCDDIQVFQNDNCARNVKNGTMPIDTSKCNGASRLTAYWLALHSPSWQIYVNCVSLAGGAAPSPSSSKPSSAPTMKPTNSPSTPTPSEDPYTPYPSESPDTPTPSEDPYTPYPSDSPGTPYPSEGPDTPTPSEDPSDDPYPSDSPNTPSPATPSPPSNGQVQGYYQCGGKNYNGPTQCASGFHCNKWNEWYSQCVPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XDK0</accession>
    <name>A0A6G0XDK0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7164 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_006113</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0738128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XDK0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018079"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055588">
        <property type="entry name" value="DUF7164"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23741">
        <property type="entry name" value="DUF7164"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7164" evidence="3">
        <location>
            <begin position="52"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7164" evidence="3">
        <location>
            <begin position="376"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7164" evidence="3">
        <location>
            <begin position="794"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="683"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="683"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="732"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0738128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1100" mass="124071" checksum="AE4A2FB72A3C1CE1" modified="2020-08-12" version="1">MSDDGGRKLRRLLLSLLAFFLVQFVVLAWYFDIKYEDIHAHIFSTKSPNNDQVFVRGVVLCFPATRFLVYMPQFRWLRRSWVEMQRYEPDKWRTDLILYMAPGTDLRPFQALGCTMTSRESPDEPNKCIVVPTYVSMSTLDFKYDFGDSINVAVVAKLDAYDYILRTDLDTFLTPAFATWRPAVMTVGQGGYEFQGYNTSAKLVRIAKSLNLTSAGLTNIGSTWYGPTKLLQTCANLTVSLMQYLHDNEFTPLEKSEEYGIQGWPNWHHGVLSLYAGHLAINHCTHGYGVEKRGDMLDVDTSSKGSTLVHAHLHAWQTMDRFSKLAFEQGAYYEENIDALDLNVIQDYAMFMALDSQRQALAPTPTPTLDASLINQTSFVRAAVVFIPRGVEGDLFLTQLRWFRRSWLHMHQSEPPLWRTDIVVVTDSTDHPVLTELDCTVENIRKTKEEPNRCVVVDTYKRLELGYRFGDSIGVVAQDIPALDIYDWLLRTDIDTFLTPAFATWKPSVMTVGKGAYSFSATNAARLTRIIGDMGFHNAGLTNLGSTWYGPASLVRACAKLTVQVMEYMREKEFTDEEKSEAYGTRGWPEWHYGVLSLYAGHVAINHCTKDSGVAKDEIMLDFPTASNDPTTKHAHLHTWQNQQRFSKFVFMSDGYKEEVKENLDLDKVSDYAMFMALDSIATPPVTTLPSTPTPTPSETIPPTTSPEPPIESMVPPSVTPDEAELSIADATSIPPSNSPPVVSTTDSSSTPPTSSVAPEVPQITPAVTEISTPPPTSITTTLAPTTSAPTPFIRAAVVFLPFEAREDYFVSQFRWFRRAWEEMTKYEPSTWRTDIVVMSNGVIKALDGLNCTTTLRKSPEEPNRCITDPTYSLLRFDDFTYQFGDSINVVAIDSPVLRPYDWVLRTDIDTFLTPAFATWRPEKMAIGGGGYQTQSNFERLTRISNDLHLHATRLRNVGSTWYGPTAQVRECANLTVSLMKYLHEHEFTAEEKSKEYGTKGWPTWHYGVLTLYAGHIAIHNCTFESGVDKNTNMLDFPTTSADDVQNHAHLHTWQDRERFSKFEFAEGKYASENISALSLNKVSDYAMFMALDSQEKASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XDR7</accession>
    <name>A0A6G0XDR7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_006173</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0738197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XDR7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011740"/>
    <dbReference type="OrthoDB" id="78934at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0738197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="141" mass="16201" checksum="C6C4C865CD02D67F" modified="2020-08-12" version="1">MGVQKQTKSPLLQINVKWLSKKQQQQLPESDAEPYAEQLKQIKEILKDHDTQNNLLPLKFHRYIKPPVHPPRRLLVSKEVVGGKPIPFTKTMVEKVRAARQAKVTNKAMKLRPIYEDDAAVELVKLQETSSNVMYRSTAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XG59</accession>
    <name>A0A6G0XG59_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CWH43-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_005265</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000067">
        <property type="protein sequence ID" value="KAF0739085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XG59"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006432"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013534"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="355"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="390"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="3">
        <location>
            <begin position="17"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0739085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="510" mass="56103" checksum="833691D4E084CD12" modified="2020-08-12" version="1">MKLLQRRQFMRGVFVPLIGLSTIAVTVSIACWLHFDCPEHLPVLSHAAEFFPEYYIFALGMNCTAYFMYDTARAHANALRRTMSGHFSFCYDAAITGTVASLCALSLFDSDKFFSMHVVSTIGFFFSSWLMLCLSHVGRLAMLRHAASAQNGVDQGKWCLIVGFLSALAFGYIYVARRWPTPTTHCVASESLSEILAVVCQLLYFATFHAHELTEEHVFLLMLRSAPTDADQESLILSIAEEDDSSDGNSSSASSEDSEDDSDDSDDELETKDSLGVVPLVLAIVVLVTCIGTVLWGCRHPRIDCKVDWPTVASAARFRPQSSLFTIGLVLSGLLSLTTLLLFHWHARITLVETSIATSATLVAGLVLVASMFAVAFWDSRSYSVSYTNGTIVLLNATLATIGGICLVRRRIVQKRASGHRLQRLQEELVIPEAFAVAATACFVAYAVANTCVNNPWMNPFGLFRPTHAAFAEYAAIVLAVSFGCTLRKELASLSDAVEQQYELMLRRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XGE7</accession>
    <name>A0A6G0XGE7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dolichyl-diphosphooligosaccharide--protein glycotransferase</fullName>
            <ecNumber evidence="6">2.4.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">Ae201684_005109</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a di-trans,poly-cis-dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] = N(4)-(oligosaccharide-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + a di-trans,poly-cis-dolichyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22980"/>
            <dbReference type="Rhea" id="RHEA-COMP:12804"/>
            <dbReference type="Rhea" id="RHEA-COMP:12805"/>
            <dbReference type="Rhea" id="RHEA-COMP:19506"/>
            <dbReference type="Rhea" id="RHEA-COMP:19509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:50347"/>
            <dbReference type="ChEBI" id="CHEBI:57497"/>
            <dbReference type="ChEBI" id="CHEBI:57570"/>
            <dbReference type="ChEBI" id="CHEBI:132529"/>
            <dbReference type="EC" id="2.4.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endomembrane system</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STT3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.18" evidence="6"/>
    <dbReference type="EMBL" id="VJMJ01000066">
        <property type="protein sequence ID" value="KAF0739184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XGE7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018825"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004579">
        <property type="term" value="F:dolichyl-diphosphooligosaccharide-protein glycotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12610:FF:000003">
        <property type="entry name" value="Oligosaccharyl transferase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003674">
        <property type="entry name" value="Oligo_trans_STT3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048999">
        <property type="entry name" value="STT3-PglB_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048307">
        <property type="entry name" value="STT3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872:SF1">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02516">
        <property type="entry name" value="STT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21436">
        <property type="entry name" value="STT3-PglB_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="267"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="304"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Oligosaccharyl transferase STT3 N-terminal" evidence="18">
        <location>
            <begin position="14"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="STT3/PglB/AglB core" evidence="19">
        <location>
            <begin position="586"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="468"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="800"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="473"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="484"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="807"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF21436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF0739184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="940" mass="104425" checksum="6ED784BA46898BDC" modified="2020-08-12" version="1">MGVIGWVIGGAVTAASLVLIGYMAAEQRMDAIRKYGMIIHEFDPWFNYRAAEYLADNGYERFFKWYDYMSWYPLGRPVGTTIYPGMQIVSVTVWQILNAVGIPMSLNDVCCYTPVWGGVFATLTLTTLTYVCTGRISSALVAGWVMSIIPAHLMRSVGGGYDNESVAISCLLLTFLCWCASLYSNDNSKASPIGILTGLAYISMAATWGGYIYVLNMIGLHAFILVLLGRFSDKLYWSYTLWYIVGTVGAMQVPVIGQAPLRSLEQLAPMLVFFGLQGLKICHHPLFLKTFFKIDAAKATRANMFFVYTVVASVGIGILAVVVQILWPTGYFGPLSSRIRGLFVQHTRTGNPLVDSVAEHQPVKNDAFWQFLHLTCYTAPVGLAIILAESVFRPFVRGTNARSDPLTFLVVYSVVTYFFSTKMNRLMLLMGGPASILTGVVGGYLVDFVLFEAYDLIEAVVGGEQKQPALAATEEKKEEDKTDKKSKKSADKKKKPADEASPSVVGKAYNSGPVKLMRKVVATVIVVVGYRYAVEFYDYTQMMKGPLSGPSITFEAQLRTGEKIIVDDYREGYLWLKKHTPEDARIMAWWDYGYQITGIGNRTTIADGNTWNHEHIALLGRCLTSPEKRAHNIIRHLADYVLIWAGGGGDDLAKSPHLARIGNSVFEDICPGDPLCSNFGFYSQGNPTPMMKKSLLYRLHQHGINPQVNVDPSRFRPVFQSKYGLLRIFKVMDVSEESKKWIADPANRICDAPGSWYCTGQYPPALDETLAKRKSFKQIEDFNKGLDEDAKKYHEEYLNRMSGKGGSSSSSPASSASSDDDDEPTPELRPTKLIGCYGTENSFDDKKYVGGQSGAFFSHALHHAVEAKTKYFAIARGEQDGHSFVFNKLKSTGKWKNSKDCDRPCLDDPAKACGCIDGACSEPKMEGEEHNRRWVVYEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XGM7</accession>
    <name>A0A6G0XGM7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_004965</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000064">
        <property type="protein sequence ID" value="KAF0739396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016174"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005246">
        <property type="term" value="F:calcium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043582">
        <property type="entry name" value="CaBP1/2/4/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45917">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45917:SF12">
        <property type="entry name" value="CALMODULIN-ALPHA-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22586">
        <property type="entry name" value="ANCHR-like_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="1073"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="1306"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="1343"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="5">
        <location>
            <begin position="1436"/>
            <end position="1475"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1046"/>
            <end position="1073"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0739396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1559" mass="185053" checksum="D86943F1EC0B4C86" modified="2020-08-12" version="1">MKKHRAAVSIQRRARGNIGRRRTNSLVHERKTKESAKVIQRTYRRFVVVQIYRREIKKKKAVEIQRMWRGRQGREMASNRRRLVFNAALSLYSANAMIALDYAGILICAAQTIQRSFRCYMTRSSIHYASRRLALRKQFFPSLRIQRSWRRFRSKILEVFLDQMLTSLVFIARRLAKRVIRRCASLAKANRTRAATVIQAHIRGVLCRVRVKTSQIQVWHEMDLKLPRCDKEYLEWDTLTTAQGMKCLFLWKKKIKCWRDGNASQIQRIFRGYSVRKVYGVRQAACGDLRQLLNQPVHKFLLGQKAARVRRRWSRYRHATWAKTFLAWKGITIAMKSIKTMRHGERLRQIARWHFEKKQKRKILLHWIVCMHLQQEHAKLVKRVMMWRDVKLKTRFVKEWKLGTKYTVICCVTRDLISLIDVFLCWAKYATLIKTSKALRAKIHTRIKNDIMGQLIQYDILCHINDHFALQKSNRAIAKAHLQALHKYNQHRKKVDYRLNGLRLKHGIQRWINWVEREQFHRDLDSKYQKFRLAHLFKRWKTLKAIIFCRDQLRQRVDRFAQKQKSIRALVQWLDFTEKSKEYSILHAKAQRLFSKTFKRKAFSGWYQLWCSTAGLRRIQSATRIQARWRGKKGCRLFANIKALHKYRIAKRIEGGVDTPEISIENIANLLRTKEWVVLYAYLPWEAPPVAIRRAFASVATSWHLRKYVSFVFCDATQIEPTTSVSLATSLGLRSRLSSLSIYWQGRGPENMPIREPSKHISRRFTKIDLQFTVAPLSFETLNPWMENLLVSAYNATACDIQAVMRRCLVRLRIYYSTQYRHRNVALLIVWWFVRFHRKWRNKNACKLQRWYRRRQEQYAAWLRANARMIELRKPIQLIQRVVRQYFRRTQLSRARAERLATPLLYPNAPLCMTCEEKVGAIKCIDCDEPYCDNCFSNIHARGALAVHRASAIDFVAMNKNMCMCGRCNVLPTQRVCEICKAGYCIICFERQHSKKSGIYNHKFIRPTKILNNKKTSKIKPIASLLHSELAEKIIVQHGWETKNRLDAASAMAAKAKQEFEDRQNKIEAIRRMLEKPVLDAFQEYDPSHEGYIGLGELRMLLTQELCIPITKREIEPIYRKIDADNDGKLVWNEILNWLAIEIVNGTFRGKVRSIRRKNLHVQKRYRKAKRRYRDIKRSYRERFRKSEKKRYVPYFDNVLQLHRLDDFQRKKQVFYRFIRVEFSMDWILEDVHDIALENQMRVFAEVFVPRWNSGDLSYEYYYDGVTFEHKFSVFEQKWDEGLKKYVFINMATSQTHLIDPRKEEVLFAQAKEAFEEVDVDGSGSVDVNELYTLLNQSLCEPISMQQVVEIMTSIDIDGNGTISFDEFYTWYGSEYSQQQVKSLKHDGLKLALRTRRNARRIAAKGYNQSMRRGKSIIKNVKARMEQRRLEKACENADPETVQLLMEGFEKHLIQKALILNRNDVAKARDWLAQKSEEMEYEAAQKREKLQRRRQEQMQVLRQAHISTKTGMKKLLSAIKVLLFGEKLNNEAEVDYILKNLRMEIEGARQIVKEEQDNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XGS4</accession>
    <name>A0A6G0XGS4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_005012</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000064">
        <property type="protein sequence ID" value="KAF0739446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XGS4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014357"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="12"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="193"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0739446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="228" mass="25684" checksum="3A9EBF93795492B6" modified="2020-08-12" version="1">MAEPTAPLLARCRLCNRDLEGQPDQCVTDCGHVFCLSCACLKLNSNKNQCSVCQTVVKVVRQMDANGNEAQREAPCNVKFCNVTYVLYVSIWSVQDPTDKLAKLFQLDHARVIHRGKILKKGDVWPGTVVQLVGTRKAGKGTDAVSTSASWWLEFVQWLLILWNAILYPFKLIYLFFHSMIWGEEYQSLPQRRYEPVDPSAPVNENSNPATFQQPGAVPLPRPTETVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XGY3</accession>
    <name>A0A6G0XGY3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_004715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000063">
        <property type="protein sequence ID" value="KAF0739533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XGY3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010556"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0739533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="126" mass="14371" checksum="B4A8D2036A3EE565" modified="2020-08-12" version="1">MGSAPTSLRVNEEFRRYFRTWDIMDVTVARMKYRQLTLRYCINMEQLAIVLGRQLPDPLVSFVFGLFAPKPIREPRSVPVVDAVEVFVGLILVCQATLAQRIAFIFDLMDSRGLGQLSESELSICK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XHF6</accession>
    <name>A0A6G0XHF6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ae201684_004703</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="VJMJ01000063">
        <property type="protein sequence ID" value="KAF0739521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018963"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05171">
        <property type="entry name" value="PIKKc_ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038980">
        <property type="entry name" value="ATM_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044107">
        <property type="entry name" value="PIKKc_ATM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079:SF4">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="12">
        <location>
            <begin position="1739"/>
            <end position="2322"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="11">
        <location>
            <begin position="2445"/>
            <end position="2753"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="13">
        <location>
            <begin position="2768"/>
            <end position="2800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF0739521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="2800" mass="317955" checksum="A0C5A39207DA50B5" modified="2020-08-12" version="1">MDMSDDFDFGLSTASSSLRTDNDIWADVKRVCRELNMSKKTRKAAIVSFSEMIASSKHKRVIHESGTWGFVLNTLLEVIEEDYSLSLKKKKSSGKITHVLEYDTVLLNVLDYAHEDVSPSSNTAVLDRDSTGKGTLKQLVSFCERLISNPNLLNSPAESSCYRLLDKVLKFEAYCRITDENCLKKILECALSTLQARNSSCVLVASRISLSLLSNLKSDLHSRLPGLMEFFHDWFQDNRVDDEDQRKQKSFGKSTTLETSGSVARNLLNSMVVIMTKYAPSIAPLLHDRAQEAVLYVQRNLREDVVVLASEPVEFLIIYYRLVFHRECPPTSTQCRELKHLYTLCILDDKILAAIVRQSANMQLTNTRTIAALNEKACLWLSMIADVLFYHDQWSEGVGQQSMKRARQMTGFDTILSHLEMNTTTSAKSSVGSQAPSTQMSTELAIPLLRWLLLLQSLLARHGRWYAEEQSDRLESLRSVLISLLGDSSLDSECKQQTLQCLLILALRAQGLHSSGWQPLWQILLSDYSFRNMTKSESGDVVLQLFSTLIIRQYIVVDTLEKDFASILELPVFANHSVLSMLILYLIKSIVDFDVCNNWSHQEIATFYFTALRKVIYTESMGFAIPLMVSAISSLFSDGPSTLDCTPYLLPALWKGFATCDITDEIEAISIMKHDTKLFDVPKSSRLSRLVMHLRSAFDENNNCDETDRVSFPKYVNKYICLDPVAHFADRLVYIGWSVGSIPTAVKDQNVIYDEIQGVLSDMMDKADSSPSDQYLVHIEALLNIGVVLAAIYDKCSFDINVLMKNLLSTVCSRIHKWQNSPPAFLLLQKLFSLLQLLGRNSSSGPDGVVKYPASCRAILGFIAVKVHELVLSQGEIDRSHQKDDDDMDLDYTTSGKISRFSLKLWCLRIYQLLQNEAKRQVKNQGNDNQDISALIRQVVGQQYIPAIEAMKLVPSLCHPLTVESFSVIIYLLENTLTSYTFETCEQIRNLAYEIKRQNFDKPEILSDIGVIFDRLLEKKKPGFKLRGCILSAYEQLFLLDADRFSNFNDFMMKHLVDIDIRVQVVSLGTLQSPYMKYFEGTEDIYNDVSNFLKNHDCSLFVSILASYVSAASADVLLSRVLALYSTWHDAHPDLLRACVDGLCLKYGFSSSLKMLEDQLWTTICHYIDLTQQLSYTSDLLDFPVCLFDQTKSKLRETPLVISIVPLLMLLDQTNNHIKLTKGLNILDTAVWIPTINVTIEWASRKAISASITQDMASFALTCMLNLNCYGGEMFPLRWSTFSSIASHPIHIVDIVLTVHTWLLEHRLHSSVQGALLFLCDAMDFFITDGSSCDVLSQRMLLHVLLSHIHHPEVAATLKKTCDFWMSEPDIFGHNLNHLVGGFVNKYSTLPVKVQEVVEAIAQSMSRIQKLGKYLSALNPFPSHISPSLSQLQRSYNVDEPLLKSLALKISQPPLLTTSLSLDALETLNNVLVSNSDHEHIPTIMYGLLSNAYQRALQENISEEQVQIATCIGHMGAIYPSENLSHDVTRLQVLYLHLFSRPSLASLSQMKDPWTELIGKTLECLMALLFASEPPIVKTALSTLKHLLTLETVRLALNQTRTFPKGVKSFLLSMPSVSSCAPKSVEGLTSWHPNAYSSFEKWICSITCCLLQQSQDAVLNACSDICVLSSRVAIFILPLAIFSVLSTIPDYLSSFEQLLAHEVMLPQQHGQIIVHTINYVRHLQTIKFERASWSLPFLQVAKLALQCKMPYSTLQYVEWHLEQTCGSIQPPQTIDPIINEILLKAYKAINAFDAIDGVRQGDSLQDQLTVYTLEGKYTKCLPLYDVISRRRKNEVDTGLLKTLYTLGLMHLLEVYTSWNENTQVSKYQFKSAWNLNQWNLKLSATTTKYDGLLYGIMKSMVTDDEKQFLHLLQQAKRNILLNQNLSFTGLETTKATHKAMLHLETLAKLEEVWNIKMEQAQPSVLGSSIHDCDTQRNHLTEKWIKRHKAYEEDFETLRQMLNVEERCLKILDWTSCLPTWYLTLAKAARKAQRSAIAFTALENLNSIVLEKSDHVLYLMEKAKLYFSIGEPSRALLIAKESHKRLTDEGREGLELAKVSSTIGKWLAHMKAERSEIIQKNYLEVATRMFDNMNINSQFGNEAANAYRTLANYMFESYNQVKTRVESNEWKRGKRVAEAQEAELKLFEATAGSQKTHSRHGILRKQVEYDKRERNLVESSVERFLSSALKNYGLSLRHAPSVDMTPVFRILSLWFRHFQNTQVNMELDEIVKSVPSFKFIPLSYQIMSRLGTTSNTNLRELVRKMTIEHPHHTIVQLLALKNGSKRGTAQYRDNVGLQKSEEAINILKLVKKENQLLLELVENMEVLCDAYITLALFDTKEFERRGVKKIALSVVPVGRDKIPFDNCLRLRKFNQTIAARPAVLTYTIKPRSDCDYSNVPRVQSFDKDFTITDSGVHKPKIIYCYGSDGIRRKQLVKGNDDTRQDLVIEQAFDIINSFLAENPNTQRRHLQIKTYKVTPLDTVAGVLEWVDNTMPMGGYLNGKPFDAHMRYHPHEWKHSQCRSHLQRAVDKYRAYMEIQSNFSPVFHHFFLEKYPDPATWYSRREAYTRSVAVTSIVGHILGIGDRHSQNILIDEASGELVHIDFGVVFDQGMTLITPETVPFRLTRDIVDGMGVNGVDGVFTRCCEETLKVLRKRGNALATIVEVFIHDPLYNWTLSPGRALQVQQEKSEDMHALLSETEDENVADLAARVLLRVKQKLQGYEDPTGEAMSVEGQVKHLIQVARDPHNLCKIYPGWGPWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XIG0</accession>
    <name>A0A6G0XIG0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase S26 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_004585</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase S26 family. IMP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000058">
        <property type="protein sequence ID" value="KAF0739884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XIG0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011875"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052064">
        <property type="entry name" value="Mito_IMP1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383:SF16">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383">
        <property type="entry name" value="PROTEASE FAMILY S26 MITOCHONDRIAL INNER MEMBRANE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S26" evidence="8">
        <location>
            <begin position="2"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S26" evidence="8">
        <location>
            <begin position="70"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="4"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0739884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="120" mass="13002" checksum="DACF7D23703ACCD9" modified="2020-08-12" version="1">MGPSMHPTLPDGVFILVDKLTLRWKPLAAGDVVVASSPVNAQGSVCKRIIAVEGQFVKCRPRFEADAERVVEVPKGHVWVEGDNATASIDSRHYGPIPVALVWGRVAYKIWPPSEFAAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJA0</accession>
    <name>A0A6G0XJA0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">IQ motif and ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_004086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000052">
        <property type="protein sequence ID" value="KAF0740346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJA0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012277"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037695">
        <property type="entry name" value="IQUB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057887">
        <property type="entry name" value="IQUB_helical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21074">
        <property type="entry name" value="IQ AND UBIQUITIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21074:SF0">
        <property type="entry name" value="IQ AND UBIQUITIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25805">
        <property type="entry name" value="IQUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IQ motif and ubiquitin-like" evidence="1">
        <location>
            <begin position="349"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0740346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="482" mass="55171" checksum="B8320CF5F1014380" modified="2020-08-12" version="1">MGNEMDESRVETEFHVVFILQPDGFRHRIAATANTTLKQIKEQVISELKLTSNTLSISELDDACAANGIHPADFTLANAGLILNSDQEIILNATVAARKIGSSEYVMPSEIDVTVTTDQGAPLKTFTVHILKFTGHKPYLGGYRHKITDQVFHHATAQTVVTKQKIRRGPARFHRETQTHKTVTKSAQTVREHGTQMTRSDLLVDERGDRQIVPNAYFDSAQLDCLRMDACLRLQCQWRAYRARCFVHAIRQKKLEAYSKDEQFAVETKAMLANKQRQEIDRRMHPKSQHDFEVLYNELDQWRLYETKKVQEQTNLDEKERTAALAAILAKETKLLQTIDRLKATATSKNRSARIEAMLDVLSRPKQWQMSDGIIKPVDTPYTVRAKELSELYHGLKLPLQSVEERLEVLLHVKWTVKEFECPLTQELMELIDREADMLNRGRPAQSVEGLRKRIANLFLQFIENPTFNPEAARLRSVIGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XK77</accession>
    <name>A0A6G0XK77_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">lipid-A-disaccharide synthase</fullName>
            <ecNumber evidence="1">2.4.1.182</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_004002</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a lipid X + a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a lipid A disaccharide + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:137748"/>
            <dbReference type="ChEBI" id="CHEBI:176338"/>
            <dbReference type="ChEBI" id="CHEBI:176343"/>
            <dbReference type="EC" id="2.4.1.182"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.182" evidence="1"/>
    <dbReference type="EMBL" id="VJMJ01000048">
        <property type="protein sequence ID" value="KAF0740627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XK77"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009204"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008915">
        <property type="term" value="F:lipid-A-disaccharide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003835">
        <property type="entry name" value="Glyco_trans_19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30372">
        <property type="entry name" value="LIPID-A-DISACCHARIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30372:SF4">
        <property type="entry name" value="LIPID-A-DISACCHARIDE SYNTHASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02684">
        <property type="entry name" value="LpxB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="454"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="465"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="495"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0740627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="504" mass="56862" checksum="982D970C201E3EB7" modified="2020-08-12" version="1">MWWRTKRLIYVVAGEASGDAIGAKLIQALEKHSQGPFAYRGVGGPQMMKTGRFESLFPMEELSVMGLIEVIPKLFVFKRRIKDVVRDVEASRPHAIVTIDSKGFCFRVLDKLKGSETRRHAAVVHYVAPSNWAYKHKHSKTAQTSASLQHLMDRMLVLLPFEERLFNKGSSFSAFVGHPAVEDFLEKHSLFRPHALKPANPKDPGFKSFPRNEWLDERLPLDVLSAQTHIFEEAMPNRQPRGDEYVICAFVGSRENEVNSTVHLVKDAITSFVNNHDKSQGNIHVVFPTVRSIAPILKDVLDGWSIPWTVEYDNDAKQKMIESSNVAVAVSGTVVIESVLAGLPTIVIYRANRVTEMIAKLLARVRFVSLPNIMMERELIPELIFSQCTSANLTTALQKMYKTASDNDGDNALLCAALSQLAVWNRFDMHIIPRRASELAADVVVEAMAIKETENQTASKSTRDNDDDDDDDDDDIIKRRPPARSYRRNDVHHEEDDDEGEEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XKY2</accession>
    <name>A0A6G0XKY2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Era-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_003601</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000041">
        <property type="protein sequence ID" value="KAF0741029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XKY2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012073"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043024">
        <property type="term" value="F:ribosomal small subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04163">
        <property type="entry name" value="Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22534">
        <property type="entry name" value="KH-II_Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00367">
        <property type="entry name" value="GTPase_Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030388">
        <property type="entry name" value="G_ERA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005662">
        <property type="entry name" value="GTPase_Era-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698">
        <property type="entry name" value="GTPASE ERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698:SF2">
        <property type="entry name" value="GTPASE ERA-LIKE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="Prokaryotic type KH domain (KH-domain type II)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="G" evidence="6">
        <location>
            <begin position="251"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="KH type-2" evidence="7">
        <location>
            <begin position="531"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="75"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="402"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="104"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="409"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0741029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="607" mass="69291" checksum="0163FE55F01F1FDB" modified="2020-08-12" version="1">MWRVSIGKVHATLMGQRTCIPATLTLSAMFSTTDEGLKKKRVSGYASAVPKWKKDRAEKFKVIAEKKKKQRDFEFNFDTDDKRQGRKSSRKAFNESTARGKGARLPDAHAFTKSDNRSKQKDNKVESKLEKQPKEEPAKSLHEIHAEQEEAWNAMRKLRVLPKEERITTPVSKKRPVPRTKSAPTVSTEDEASDAIAKRNRFLLREKAKRLANKQNRIFDGIRAPPQDVVEPINTYEEPDSPRGAKPRGLNVAVIGRPNAGKSSLMNALLGFNVSAVSAKYNTTRDRVLGVMTEGDTQIAFYDTPGLVNLKDSHTYVRSLAVTAAETMPSVDVSLLVVDAVKRIDDQALEALKNIAITSAKEDAPIMLVMNKMDLVGPAEKIHVAKRIDVLSDMIEDAFASHSPKSSEYSEDDEFDWDDDEDFDDDDMEDDDFDDEEDELDDFDMDDYDEEDFEDDFNELDLEPTAFLRDKCFKVSAFKEKDVDKLRQTLIDLAVARPWMYHSKTKSDRSDLDLVTEIIREKLFRRFNQELPYMITQENRGWTPFSDKSLRIDQDLWVPSDRHIKTLLGKNGNTLREIGTAARVDIQKLLHRKVHLYLNVRSKSGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XL28</accession>
    <name>A0A6G0XL28_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_003636</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000041">
        <property type="protein sequence ID" value="KAF0741064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XL28"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005642"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16485">
        <property type="entry name" value="mRING-H2-C3H2C2D_RBX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000010">
        <property type="entry name" value="E3 ubiquitin-protein ligase RBX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051031">
        <property type="entry name" value="RING-box_E3_Ubiquitin_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024766">
        <property type="entry name" value="Znf_RING_H2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11210">
        <property type="entry name" value="RING BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12678">
        <property type="entry name" value="zf-rbx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="63"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0741064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="118" mass="14089" checksum="794EE84153415703" modified="2020-08-12" version="1">MLVRFTSEREKEMEETKQDTNMEVAQEEQKRFEIKKWNAVALWSWDIVVDNCAICRNHIMDLCIECQANQASATSEECTVAWGVCNHAFHFHCISRWLKTRQVCPLDNREWEFQKYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XLD5</accession>
    <name>A0A6G0XLD5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Crinkler effector protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_003569</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Host cell</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000041">
        <property type="protein sequence ID" value="KAF0740997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XLD5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000831"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018013"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043657">
        <property type="term" value="C:host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052980">
        <property type="entry name" value="Crinkler_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045379">
        <property type="entry name" value="Crinkler_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33129:SF1">
        <property type="entry name" value="ATP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33129">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20147">
        <property type="entry name" value="Crinkler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Crinkler effector protein N-terminal" evidence="4">
        <location>
            <begin position="4"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0740997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="625" mass="71802" checksum="AEFC6025B6F8D694" modified="2020-08-12" version="1">MAEVTLNCAVYADVTMFRLTIAVNAYVSELQQAVFENQRHRDRFKFPASHLKLYLARKKNRRKKSVWLANDGKLKTFLRKSDVDKEYKEMNPLSPLNQYFGADFQPPEGKIHVLVELPDVQETALPNKKQRLDWQSTRWGSHDYDPNSQFFLLEQQDADKSGLLPVRMKLYCRPIFHRQFEFLRDEVLSKGHLGWILGPTGTGKSTTAMAFMSTLNRSEWMVTWIHVGKIWRCVRLIGDERKSRFFQVSDLDEVLMDDDTRHHVVLVDGKCLRWFLERKESNEEKQRRLAFVCSVGSRGKVQEDLEFVTGAKELFVWSWTLEEYLNAINDDEVFEMVSQNLDAPAVLTKKKTMTRAVMVESKYYYAGGSCRYMFQFNTETVATKLSDAVDALDDAKNDATSGQRSSLSINRLSGMFKRPNDVGAVYPVISQYAGTLIAVKCGPKAIKRFMSTRRDSSNPALNGWMLEMVFFASLRNGGLDLIDAAGNVIEKWNQSDLIIGDKIPKLPSAHPVWIKSLKWNQGGYDAIMVCKSTQHVRFVQVTSADTHSFHIEDFSEWLNLLSMSQESFEVKKLEIIFVIDQDKLDDFKFTTVTGTGLLEPFDWPKGKETDLVRRVGIRNLYNLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XLJ4</accession>
    <name>A0A6G0XLJ4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_003629</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000041">
        <property type="protein sequence ID" value="KAF0741057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XLJ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005649"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052420">
        <property type="entry name" value="Espin/Espin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24153">
        <property type="entry name" value="ESPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24153:SF8">
        <property type="entry name" value="FORKED, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0741057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="331" mass="36502" checksum="707110A14C76238D" modified="2020-08-12" version="1">MNQSQQPLPLLRLAKICDWGGLRKAMDKASQDAVEATDEYGMHVLHWAVTEANIPIGLLEYLIRVFPQGVRLFSNGGFLPIHLALMAGASVARVQRLVESFPQSTMIAIPSGHTPYLIYLEHLPMDTQALKRADGQTAHAAHNVHVWGNILVGHVLKTTNTSIPTLGAANVRSNRSKSRRHSSSSVPLYSASPAMLRSELKAEESSVVDWRELGRRMALQDPTLDDIIEDKSYLVVQATLKAPFELFEWLVHLCCNSVRIKNNAGMLPLHIAVTHHASARRLGKLIQAYPESVHALTRQGDTAWSLAQKLHADPTVLDVLHPSNRAMAQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XLW1</accession>
    <name>A0A6G0XLW1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WRKY19-like zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_003477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000037">
        <property type="protein sequence ID" value="KAF0741367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XLW1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010591"/>
    <dbReference type="OrthoDB" id="68605at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056866">
        <property type="entry name" value="Znf_WRKY19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827:SF1">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24906">
        <property type="entry name" value="Zf_WRKY19"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WRKY19-like zinc finger" evidence="1">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="WRKY19-like zinc finger" evidence="1">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0741367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="412" mass="43605" checksum="0C520A627A4D9BE0" modified="2020-08-12" version="1">MASKICRMAGCNRFAQCAGLCIGHGGGKACKIEGCSSTAQGMGLCSKHGGKALCSVKNCTNKRVYRGVCKSHGGSRICTFTGCTNKDVGKGLCVTHGGGTKCSMANCEKVERGGGYCKAHGGGKKCTIVGCTNWAHYGGLCPMHKNPPPAAIIPDPSPLCKTPGCNKVDAGSGMCKAHGGRKECIVDGCTKTQQARKRCREHGGSRLCEEEGCNKTAQYKKLCKAHGGRKQCIVEGCENVVKTRGYCIRHGGGTKCKTAGCQGIDRGGGHCKAHGGGKKCGWQGCLAWVLGGGMCPAHAHNAQVLGLGTEDPIQQPTTQSPPDQAYTTFAQTTTQPAAMQQPYHAQTPFPHYLQQHIRSQQAVAAAAAAAAAAQQQHIQQYQHPDLTQPAMMEMRRRMLPPFGYGEDYQYQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XMC0</accession>
    <name>A0A6G0XMC0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">hydroxyacid-oxoacid transhydrogenase</fullName>
            <ecNumber evidence="4">1.1.99.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_003218</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-3-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + acetoacetate</text>
            <dbReference type="Rhea" id="RHEA:23048"/>
            <dbReference type="ChEBI" id="CHEBI:11047"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="EC" id="1.1.99.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>4-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + succinate semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:24734"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16724"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="EC" id="1.1.99.24"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.24" evidence="4"/>
    <dbReference type="EMBL" id="VJMJ01000036">
        <property type="protein sequence ID" value="KAF0741535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XMC0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000383"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047988">
        <property type="term" value="F:hydroxyacid-oxoacid transhydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08190">
        <property type="entry name" value="HOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000003">
        <property type="entry name" value="Alcohol dehydrogenase, iron-containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1090.10:FF:000003">
        <property type="entry name" value="Probable hydroxyacid-oxoacid transhydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056798">
        <property type="entry name" value="ADH_Fe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042157">
        <property type="entry name" value="HOT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496:SF83">
        <property type="entry name" value="HYDROXYACID-OXOACID TRANSHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25137">
        <property type="entry name" value="ADH_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA" evidence="9">
        <location>
            <begin position="30"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-containing alcohol dehydrogenase-like C-terminal" evidence="10">
        <location>
            <begin position="253"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0741535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="455" mass="49307" checksum="3E67A54224E6300C" modified="2020-08-12" version="1">MVFVPLLRSAPRRLFSTEGRKDIACELAASSIRFGAGVTAEVGMDLKEMKAKNVVVFTDKHLRELPAVHTVLNSLADNGVRAHVYDSVRVEPNDQSLKHAIEYMQGLDFKVDAVVGVGGGSVLDTAKIANLYSMYPPEDFYDYVNPTVGKGIPVPGPILPFIAIPTTAGTGSETTGVAIFDDTRTKSKTGVAHRRLKPTLGIVDPLNTATLPANVAKFSGFDVLCHAIESYTAINYTERPYPATPNHRPAYQGSNPISDIWSLHALEQTNKYLRRAVQDPLDTEARSAMILASTAAGIGFGNAGVHLCHGMSYPIASQVKSYVPPGYEVDHPMVPHGHSVIVTAPAVFRFSGSANPERHITCAKALAFGSDRWHKYNQMSQKALHDGAGQILADEILRLMDDLEVPLGISQLGYNSNDIPSLVKGTLPQHRVTKLAPRAAGEEELTDLFQDALKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XNG7</accession>
    <name>A0A6G0XNG7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_003044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000034">
        <property type="protein sequence ID" value="KAF0741853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XNG7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000944"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0741853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="404" mass="45501" checksum="1751F4B05E9A19F3" modified="2020-08-12" version="1">MDSTPRRQTSPTSNISSPDREITHSFDEYAQIPEPYPSYSESLDSDQTVFVPASELAETSQVYRHAALHTSFLSPFVTDAYSSSPSTSFFGKQSYSASPPMLSGFTKSLEEYHSSPRRFDALHSPSTSAIPSDPYFQESNVPPVVRELYHKVNPYFATKAQPVECLQFFAETMRTLGFQYTIRQNWTILVVGLLCVEEVTFTISLKQGDDHLVVDFNLHQGSERNFLRLFDIVRNYARSLDLHPESVYSTSAEWLNVDSMPELFPGSSQVSKSVLLEYCEDYMLLAEEIGVSTRGDQARLEMAVCIKNACLSEKTRQLISQDADVGVMFSKTVYRMAHDEQIGIVRFAVFILSLFDMPTLVHLASQVQGEDNMLSVLKDIETHDPIPKMKSIAETLRSKLVATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XNP9</accession>
    <name>A0A6G0XNP9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SMP-30/Gluconolactonase/LRE-like region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_002951</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000032">
        <property type="protein sequence ID" value="KAF0742014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XNP9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011513"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051262">
        <property type="entry name" value="SMP-30/CGR1_Lactonase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47572:SF4">
        <property type="entry name" value="LACTONASE DRP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47572">
        <property type="entry name" value="LIPOPROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="2">
        <location>
            <begin position="53"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0742014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="288" mass="30385" checksum="FCE3EF5FC5AA43B3" modified="2020-08-12" version="1">MASYLQDTIRCKGAKICSPFVREMGGKRVVGYVSSATGEVFACTEGKHVLLTHTGGEPMGAAFDSHGKLHLADCAHVAILRTDLAVHNQQPGIVVKEYEEKPFKGPSSIDVATSGVLYFTDSGPFGETTLAEPRGSVFCIAPSPSGGQVLKPLALECLAHPCGIAASPHAASCIYVTEMMSNRLLRFVQRPAGVYHCSVFYQFAGGIGPSCVACDATGRVYIGSYDFAGSSDPNGKIYILSAAGILEHVLEVPGPEITGICVESSHTLIVTEASTNSLHCITLDAIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XP49</accession>
    <name>A0A6G0XP49_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Presenilin</fullName>
            <ecNumber evidence="11">3.4.23.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_002833</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Requires the other members of the gamma-secretase complex to have a protease activity.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer. Component of the gamma-secretase complex, a complex composed of a presenilin homodimer, nicastrin, aph1 and pen2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endoplasmic reticulum membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Golgi apparatus membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The PAL motif is required for normal active site conformation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the peptidase A22A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.-" evidence="11"/>
    <dbReference type="EMBL" id="VJMJ01000030">
        <property type="protein sequence ID" value="KAF0742165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XP49"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002292"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070765">
        <property type="term" value="C:gamma-secretase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044351">
        <property type="term" value="P:macropinocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.100:FF:000003">
        <property type="entry name" value="Presenilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.100">
        <property type="entry name" value="Presenilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001108">
        <property type="entry name" value="Peptidase_A22A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042524">
        <property type="entry name" value="Presenilin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10202">
        <property type="entry name" value="PRESENILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10202:SF13">
        <property type="entry name" value="PRESENILIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01080">
        <property type="entry name" value="Presenilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01072">
        <property type="entry name" value="PRESENILIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="3 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="11" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="427"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="257"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00053367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00066080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0742165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="458" mass="50568" checksum="B0FE00B8CB3BA587" modified="2020-08-12" version="1">MNATSHPLVPARSPQDREMDSHDNKRVDIEDLIQSLGSFQAVIFPVTLTMLLSSFASAVITDPDAASLMAQSYLVYKAEDGDSDSTLLGHAFVNAIVIVGFFIVATFVIVICYKFKFTNFLVGYLFLSCVCLLGLLGGRLVQVSLSNFDIAVDVWSYWFIMYNFAVVGVLAIFYQKGVTTTLTQSYLVAISVIMAWQFSKFPEWTTWALVVVLAFYDLCAVLTPCGPLKCLVNLIQQEGRPLPGLIYEAEVQTTFHSTHAGGPDTAYYQRGRPFPERTESNDTSVASSSCSFTRRRSRQESDEETGESGREPLLAESAPPTLRDRLVAFYTEFNPSAIPRVDQVLAMYEGREADLWADLAAKYGVDNAEDEDNTIKLGLGDFVFYSVLVSRAAVFDVSAMWACLVSILMGLGGTLFLLNVYKKALPALPISILLSVAIYLWLRFVLIGFIDVTQGVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XR11</accession>
    <name>A0A6G0XR11_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sof1-like protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_002256</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat DCAF13/WDSOF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000023">
        <property type="protein sequence ID" value="KAF0742859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XR11"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010282"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000132">
        <property type="entry name" value="DDB1- and CUL4-associated factor 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007287">
        <property type="entry name" value="Sof1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051733">
        <property type="entry name" value="WD_repeat_DCAF13/WDSOF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851:SF0">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA U3 SNORNA ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04158">
        <property type="entry name" value="Sof1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="62"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="105"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="278"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="321"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Sof1-like protein" evidence="9">
        <location>
            <begin position="354"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="408"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="419"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0742859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="445" mass="51075" checksum="66F7C40C3ABED500" modified="2020-08-12" version="1">MKVKTISRVESTFTQELASDRTKIHRNFDPNLHPFERPREYTRALNAVKLDKLFAKPFIGALDGHCDSVSCFATSKKSLVQFVSGACDGEIRLWDLPQRKCVWSVYGHAGFVRGLTIAPDGNTFFSCSEDKSIKQWRIQIASSTDVPEPIQTFHGKESFMGIDHHWNNSTFATCSSVVQVWDHHRSDPIHHYSWGADSITSVKFNPAEASLLASIGSDRAINLYDTRLAQSLRKVIMEMRNNALAWNPMEPYHFTVANEDHNLYTFDMRNLDRALMIHKDHVSAVMDVAYSPTGKEFVSGSYDRTIRIFNVRSAKSREVYHTKRMQRIFAVHFSADSKFVLSGSDDTNIRIWKAQASRNLGKLNPRERKKLEYQDALKKRYRHLTDVKRIANHRHVPKAIKKATAAKQEAKEREAKKMANIRKHSRPGKVPHVDIRKKSVVRQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XSP8</accession>
    <name>A0A6G0XSP8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HECT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_001760</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000013">
        <property type="protein sequence ID" value="KAF0743619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XSP8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005342"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045322">
        <property type="entry name" value="HECTD1/TRIP12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="4">
        <location>
            <begin position="710"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="1013"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0743619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1046" mass="119011" checksum="C91FBD90D0B07368" modified="2020-08-12" version="1">MDDLLLTAGDPDALLVPLFALIESQPLEKERLVELSTLVTVLDRWYYCPSVSMLMIRALNAVLDKDPAILDEEPFTPSTFETILFLGFGLDDIDATSLVLDWCLLVASHQPTSILQHGFLYLFLHEHHHAHVSLRRRLTKLAHELLHVDTQRNIAELLSCADSIAEMTLDSDGQVARKALQWTYYMMQHAIPLQPTYAILWVHHTSVLTHWFTLFSTTKDMNIQAALLNFVSQLVQHGVDSEWVEKSFDLCFTSTSSYPLKQASVRFLAAISKVGCMQHDKTSVEQLSSSWICQTCTFENPSDVGLSNCLVCDAFRDEMPRLDHLKSTWRERRAQLKPSDSTLPSTVFHTVDLSRFGPHVYKFLRYEALQDDVISSLPLFQKLVDPSNPKHLFHFADILGILATESEDIDVLSHVKDFAPHDTTLWNQLLAKHGVHSTATNTSDWKQFLEIENDVVKISEYASVNPPTWFETKKTLKYVARSPAPLLALRRDALDFLFFKEQAPSFRAWNELRNCRIHVNPTQCVDTLVHPLLCLKSLVNAVQEAADNFKSSEDKFSSTMKFETLVVKANEHPIISTFDCWTKARQKMLSSDSLCNTFDEYTDSSIMELFLYPQDMPMETTLPLPAVKHIKEPLPRLSWCVERLCQIEWRRLSKQLPSEFSSFLRAQPTLVPLNIRTKFYMGDTSTREMREVAGGRHTAQVYRTSLISSSESVLKWPSSNVLYVMFEGEKGHGVGPTAEFYSDLSREFGHCQWGLWHIVNRNDDKYVSSPSGWFPAVDATTEKHLRIFDMFGRFLARSSLDGYSINIHVSVAFLKALQGQELTWRDIESVDPNFFGSLTRLNKYSHEDLDAMELYFTMPGYGSLELCEQGSERKVNGDNLAEYVSLIQAKWEKSVQAQVEAVLQGYSQLANPAALQFFIPEELQELWEPDDSKLWTYEEIVANIECSGGYSWATSSIMSRLGDLLLTMNRTERRCFLQFVTGTPCLPVDGLGQVKMSIVRVPYTGALPTSNTCQRCLKLPEYESAEELQVKLLLAIAEGQAYFALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XT15</accession>
    <name>A0A6G0XT15_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_001696</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000013">
        <property type="protein sequence ID" value="KAF0743547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XT15"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004818"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
        <property type="entry name" value="FYVE_like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="5">
        <location>
            <begin position="253"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0743547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="449" mass="49856" checksum="69B4916B5077721C" modified="2020-08-12" version="1">MMPQSGAGDLEPTSEQYVEFSMRTQSLVNETILLTANRVGFYGQKVLDKMGLQVFAEKGVSTVCRGHLSMTLADVQYALYAATTDEVQTVAAILYGQQYEDAAVVHVAEMSSADDPFQFLGVKRVRLAKKGVFAKPTQSVYVEACGTRRDGGITRLYQVVEFVDVNYLLARTLLPVCTSISVFEPHPLDPKCVHVYSKVLYSKETPAYLMQIHHHTAYWQRHIALQSLPVARRLVSESSLTDPHVPRSTPKVCAVCDSPFKKLRPKHHCRRCCCTMCHACSIPIQLPSAMFKYCTRCVLQARTRDDGIEQAIGSRLSDHEFLSTLRPIEILPTVVAEALPPSPVIPPASPVKLPASPVKLPASPVKPPAPRIQQEAQVQALQRITSSLAEQEFLLLSMREALEVQHHANPVHVPEPLSTKRLDTTNTVLLPEPLLPTRSDAPDSRFEYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XTA0</accession>
    <name>A0A6G0XTA0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rubisco LSMT substrate-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_001508</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XTA0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004259"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10527">
        <property type="entry name" value="SET_LSMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1420.10">
        <property type="entry name" value="Rubisco LSMT, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015353">
        <property type="entry name" value="Rubisco_LSMT_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036464">
        <property type="entry name" value="Rubisco_LSMT_subst-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF148">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09273">
        <property type="entry name" value="Rubis-subs-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81822">
        <property type="entry name" value="RuBisCo LSMT C-terminal, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026116146" description="Rubisco LSMT substrate-binding domain-containing protein" evidence="4">
        <location>
            <begin position="19"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Rubisco LSMT substrate-binding" evidence="5">
        <location>
            <begin position="332"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0743865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="475" mass="52120" checksum="08EEFC6AEC451F5C" modified="2020-08-12" version="1">MLSFHKVALLFFASYALAGDGLPRYDAMKRQPGHGLILDSRAEKQERAVNVELLQDNLLGNEVQLLAEDVVHSAHTHKVEVSGLVPGRGRKYAAAVPIAKGEEIVSISIDDVMSIETAKTGRINMLVEANDHLPPAVVLALHLLEEKFKGVDSHWHDFIAYLPSKLHSTLFASDENTELMEGSHVGRLTETRRQAIADFFAALESPLTSNVVDPPFFTPAQFTLKNFQWAMVAVWAHSILIPKEGNNTSNEPFDAVLVPIVSTLSPCDDCENHITVEDGYLSLVATAPLAVGDEIQLSLGANSMALYMLNHGFVPKAPSPHDVVQIGLQVESSDPLLVFKNEILHMMNMTMDMVYAPAYGASTLAPSMLQSIRAKVLTTNELKAYKRVLEKQVVSIRNEHAVCRALVQSIKALLGQYARSPAQVDAGLADPNIASVTRDILRAVQVEQTILKTTHDLVLAHWSRLLTDDSLLPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XTL7</accession>
    <name>A0A6G0XTL7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">IC97/Casc1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_001615</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNAI7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XTL7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000802"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031826">
        <property type="entry name" value="IC97/Casc1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023247">
        <property type="entry name" value="IC97/Dnai7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20929:SF11">
        <property type="entry name" value="DYNEIN AXONEMAL INTERMEDIATE CHAIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20929">
        <property type="entry name" value="LUNG ADENOMA SUSCEPTIBILITY 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15927">
        <property type="entry name" value="Casc1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02043">
        <property type="entry name" value="CANCERSCCP1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IC97/Casc1 N-terminal" evidence="3">
        <location>
            <begin position="30"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="640"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0743975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="669" mass="76086" checksum="21C2499F2C929029" modified="2020-08-12" version="1">MPPKKKKGKKKTKEELEEERRLKEEEDLRIRLEEERRLEEERKQREEEEKKRREEEAKNRAAELVRLAEEHESTKGEHEARVARLQRELQLKKDARDWEKYLACDPKPDAAIEGDINAFLNSWILDTNVTDMASTVQFCEAAHLVALDIYFLHTRARALKLDDEVKRCDSYYAKLIQMTNEKLDATTAHLLQCADEFLDPTGKGEVKLACASGQIKVGLWMNLVPKGLRNKKIDFSELDAIIDVPKPVVMQALAVRLVHLPYDINSVDTSSQNIDHPLGGIFCIDLLKIPAPPKRARGWIMREINAEPNYRLDYPLEGTVATATLAIKVSIRLPSNVILPPNPRVGWWDPSTHSWSDEGISDVLLHEDTNQLYFNTLKLTHLAVLQRRNVNHIKHCWSIKSTVVTENTSGATCAAQLILRNDMYHKIHFEVTDIGVRLVSPSVKPLESLNATYLPPHDLLARLTIAGINLTPSLVDDARFGVVPKLPVLEEKVISELLELVAAFEVSSLSGEEGEVSPQWESWSSNPRRAVFSVKEIVWPMTGDTEATPSVIEQKIHVLAEVDPDTEAQVKFRTESISDNPYDTYVHLKHALSALSTPDAKDRMANSNLLFEFYLLKMLSLLRLFSYTEPPKHRVVEVTTRKNEKLDEKIAQDESEHRPPTVPNDEVHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XTS4</accession>
    <name>A0A6G0XTS4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Elongation factor 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Eukaryotic elongation factor 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_001487</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XTS4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002726"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18626">
        <property type="entry name" value="CD_eEF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015688">
        <property type="entry name" value="eEF3_ABC2_chromodomain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047038">
        <property type="entry name" value="eEF3_chromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF127">
        <property type="entry name" value="ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="9">
        <location>
            <begin position="271"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="528"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="765"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00050030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00050045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0743841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1148" mass="125634" checksum="CC26BB40BA13A41C" modified="2020-08-12" version="1">MGKAQKEKAAAKAAAAASMFGRPPPPPPPPLAPTSNSLKFNPNASSYVPGSSHAGPAPPTAAARSTSVQSIQSSASEDEGDDEPVRILSTDEEIAAFKESDVPSQMELVQNLLDKVSTRASRNIRQSAIDDLVKAVEILGIGSYAGIFVMDEIKRFVSEKSANMREGGLLLLIGMSKCDVIAAAVEPILVEQFVPIMERHADKEPQIRDAAGRTAAAILNTVSPLATHTILEEVFKGLGLKSWQSKVATCDFLRHWSARAAHEVSSALPDVIPRVSEVVWDTKPQVKEAALSALTAACSTITNDDVLPLVPVLVNVIANPEQTVKAIDSLLATTFVSNVDAPTLALIAPLLNKSLRDQTTNSSSLRRKASRIIDSMCRLVSRPVDIAPFVPLLLPQLETVIERIADPELAEVASDARACLKRAAGEGSAEEEPAKVRAALQQALTQGLHDALDLATHPGLTEFTLHYITDVCAELVMTNRGKEWRGFVMPYLLPHMQDEDADHVCKALRKAGGGLGDDREVSVDPNDVCDIDFSLAFGGKILLRNARLRLTRGHRYGLIGKNGVGKTTLMRNIANHTIEGLPTHLRTIYVQHEDVVPDKGSMLESLCADPIVAHNDRQTVIDTLTGVGFTHGHMDGTIAALSGGWRMKLSLCRAMLYNADVLLLDEPTNHLDVHAVAWLVGYLNSLENMTVLLVSHDTGFLDNVCTDVLHYEQKQLVLYPGSLSHFVELHPEAKHYYELSASDTQFIFPQPGRLDGITSTTRRILSMEHVNYTYPGASKPQLIDVSVKLCLASRVAVIGANGAGKSTLIKMIVQETSPDGEGEMWKHHNLRVAYVAQHSLHHVEQHLDSSPVEYIQWRFGGPGGIDRELDTRVNVAPSEEEKAKYGQKTGQVECIMSRRQVKKILEYEVKFVGMTEKHNKFYTLEQLQEMGLGKLAEMEDIRQATLAGGGDLRSTTTREVQKHLDDFNLNAEFGTHGKIRGLSGGQKVKLVIAAAMWVRPHLLVLDEPTNYLDRAALGALADAIRRFAGGVIMISHSEEFYNSLCTEKWLVESGRVRVIGEAQETEYRLGGGKKVLEEEEPDPTRSAFGSTNDKIKVTGVIINPKSLRAMSTKDIRKMQKCAKAAGRSLEEHVAQLTRDSPEWKWLPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XUJ6</accession>
    <name>A0A6G0XUJ6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_000831</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XUJ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006656"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="46"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="300"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0744343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="325" mass="36430" checksum="F54C19B720571496" modified="2020-08-12" version="1">MATTTTAPSLASSQQQQLHNLHSTIQGIPGCPLLALLTAEIPWETLVELMTTKYYSVGQFVWTQGQVPTSVGFIMQGQFALQMKPEAVGSTPKSDKICNPGACISAFPAYYQVPLGYSVMALSYKSSVLMLSTAKFKTILKQFSRSKERQILQLLETMHKDDLNWIEQSFPLQGDHMTTVMGSVSPMTRPIEYENTNGVLVIHEVVTPVSSKPRLDPICAKAKANMQRRLDQLHTPEHYNHLETHTGQRKHLSYLRRRANDVDSREKPVGRLLKPMITSHASSFVRAERSHPCEFRPLNSPSTSTPPRSQSTPSLFTLLQAMHER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XV41</accession>
    <name>A0A6G0XV41_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fungal lipase-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_001004</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XV41"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009256"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051218">
        <property type="entry name" value="Sec_MonoDiacylglyc_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856:SF24">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026230731" description="Fungal lipase-type domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="369"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="399"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="457"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="481"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="531"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="569"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="3">
        <location>
            <begin position="682"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0744530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="895" mass="99207" checksum="AC800E715F89A846" modified="2020-08-12" version="1">MTAMFMLVIVACIGFAMAADIPMDLSRSCSVGGAFGLFQSESGCGIGNCQCFPVLFKCDPALGNGLGQCRLSLIGALLLVLAAMITVIVPVYFVVQHIYNDTGKNNHDVAIIQKEISTRRIILTKQMTKELQEQLDVDSVPSTDETEMYFDMRQFRKTVPSKTIGVDRKPKIKLEAMGKAWIYVMFIFLLLSTAISLVIFMVPAAVSTEQTPLTLENIQPLNQTAFAIDATVRLAPPRGTRFLSVAGGLCELISPTEPGLTLLNASYDMSFSVDNENFFNSYIGYALIQCDCTSSSCFLSSNYATSTFPLVFAPWYFDQFRPFSAPAERDFTYHVALDLHVAPRSLDFISLSLVSHYSRVYMIVDGTKLAFMVGDVLLLIFWTWINRKVEWKHMLPERRLLFVLLICNFLGSGPVMHVLTIFFSDSVSYLFSQSWTVTMNAAWLLVFFVLIDYQRRVSLVFSYGAIPIAAAAVTLRHISFYLYPASVTSLFDVCLSVVSLWLFRADAMSVRNTLRRRPYAATRQEQLTARVLYIISYCVPYVYFFAALAADPLPVVHSYIGTTKTLTNLPTQIILRASTLVLVLAFLPPSKRDRNAAAECIYTTRDAAPSTSKHFSIETACSMYNLSCHAYYAAPGFKNEPSDSDMDVTTLGRDDIEVIAAIYDQTTDTHGVVFADDTRLILAFRGTYSTKNAYTDLAYNFVSPNDDAAWAAPDVRIHAGFWTAYQSVRDQVIAAVKEHCAGREIFCTGHSLGGALATIAAVDVAATIGRPVTMYNYGSPRVGNHAFAREFNSFVEVAFRVVNDGDIIVGGPKRAILCLYCVSSLRYKHVGKTVLLSERANGTFIVDPNLVEMAFMAQLRGNGFSHFLGAYKVRLLKGLQATATERTPLLNHTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XVX2</accession>
    <name>A0A6G0XVX2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_001009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XVX2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009251"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0744535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="543" mass="61723" checksum="BD5CF45C8EAEBBB6" modified="2020-08-12" version="1">MGREQTTAKARMSERPPLTKIYQRGASVTQIRPRNPEVRVESTANEPIEIDDDSSDEDGSAEKSPIKPAKKVKVVKPALTTKGKVKKASKSKPSLDSKPSEMPKVREQSPKREPILHGKPTETPSVKEKSQEIVQTITPSKSNDEKPRKSNVDKEKIKAMVILRTRATVAFIRYLRSKGHQTGDTNSLLSQFFLEQPKFRASQLNEERLGRYSKGILSMKNGKLSVHALKNIPFRTISLRQVHEKNISYTLGFCLRFCHFVVSNYPSGCDLAPAIEAFCDQFGIRWQDVIVLKSLLAFYCSRILQLNDKHAQTELTVCHGAEQEILRLVSLLLVVWLKQEYRQCKAPWIQALNQFRHKYHMPKMKLNHYSLMAFPWLNNFKMNKSAVVWTVEWEASKVPPSLLSLYVEHIQPQMTPNSQVPYIEANSLIFLEPIDDGGENLKQKTEEHYLHRQSTGPQSTNVLVENSTLKAPITNTALPAQESMKSIPTTITNKPAKKAERTKPEDPEKTDANKRQRVQQSPQKDAVFKYISFISLANSVQDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XXG0</accession>
    <name>A0A6G0XXG0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">E3 UFM1-protein ligase 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_000324</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XXG0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018144"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061666">
        <property type="term" value="F:UFM1 ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990592">
        <property type="term" value="P:protein K69-linked ufmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032434">
        <property type="term" value="P:regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018611">
        <property type="entry name" value="Ufl1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056761">
        <property type="entry name" value="Ufl1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056579">
        <property type="entry name" value="Ufl1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31057">
        <property type="entry name" value="E3 UFM1-PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31057:SF0">
        <property type="entry name" value="E3 UFM1-PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09743">
        <property type="entry name" value="E3_UFM1_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25041">
        <property type="entry name" value="UFL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="E3 UFM1-protein ligase 1-like N-terminal" evidence="2">
        <location>
            <begin position="3"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="E3 UFM1-protein ligase-like C-terminal" evidence="3">
        <location>
            <begin position="621"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0745294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="727" mass="80699" checksum="0BBBE000400F1D83" modified="2020-08-12" version="1">MDEIRALQRELAMVQEAKGSIRLSDRNLIDLLVKMQGLNKVELIFTTNAKTVLTPAHVIKEIHDELVAHMGRVSLQDIYTSVNVDMSYVEQYAKQVVEESASAADAHDRILLVDDELIAEWYLNSIMEDVNEILQEHGQISLGELAQQYGFAVDFMTNVVDKRLQTILKAQLKGNILYTEALVARQQAQIRGTLSAITRPTYLAEVVALTGLEERLVYDTVVELISTQQLCGTLRGREYVPTIFLDVQRESMYSFFQTNGYATHVLAAQLQITGRPSEFIKKRFQDCITLEDVVVSATLFLQLEGAIDGLKHDATWLDARSVLPSAIDDKNTSQLVSLAIQQTSTTVPGTSAVQLGGVFVVSSTFLSRCLDKFQEHAAESVSEAALSLMHAKAATAADPSKSAKKKAKSKTSKSSDGICPSKDEQSQLIMTWFDHCEDQDDFVANLVQSMAAKVQAVYDAALAKALASIHRGDSFSRREKFEDLFDELHCHLLVFQKGLVKLSILAKDQPDAVRSIEQSLLSSLAVEMSSLVLMFVNESLELNLDGFPKLFESTNANASNFTRLLTKHRTILEKKVPYAATLIKLWTLAQAQSTLSEFMTFIPTIADALSMPLRKFDRKKEKALVSAHKQQLMLQLESEDDLNHVLSITFALLFQTTTSLAIRLPQDASIQAAYPALRAAISLPPQAAEFVHELLDAAAEKPLQKRPELVVRAVTLVSLKDFTEFTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XXX1</accession>
    <name>A0A6G0XXX1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_000381</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XXX1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019684"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26200">
        <property type="entry name" value="Rcat_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="2">
        <location>
            <begin position="30"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0745358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="460" mass="53324" checksum="C5D3040D8BCE9950" modified="2020-08-12" version="1">MHLTEELPLQDAPTDVETLQPSDTKLKYACQICLEIVDLEIIITGICGPTCLASVCVDCLAEYIDVRSQSLPRGVLAKLNCPICNRPVNETRWKERRPHTADLIDVFADRVAASCTILCPSCHSQYNALPCPVDQGLNELVDLQPSYLEKLPALDEICRLYCQHEISPDALCQLVRDAFPNHHTEVNRQLLLYIQDTERRAALFLRLTREQPFIRTSCCSADICFTCKTKDHHHGVPCHARTTTNEDLAACPSCNLTLVKGDGCDQMTCFCGSSFSWRDQVQLRRWSMIPRSRLAFFAAVFRRFVWLRRFRQRVLPALRRKVNMLKFKSVYLAVCTYLRGMVHRRLVQRSVLPELVFVVAMRKFRAQFVAVCEYLRAMVRRARRNRRLFPEMKSRVFIKNLRQEKKPMLAVREYLRSRAWKKLFTKKVLQSKEFYDVVLLRKSSHCFTTVHAFLNSLRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W3Z2</accession>
    <name>A0A6G0W3Z2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aldehyde dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_018939</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000367">
        <property type="protein sequence ID" value="KAF0721761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W3Z2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020446"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07087">
        <property type="entry name" value="ALDH_F3-13-14_CALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000003">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000004">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570:SF16">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE TYPE III, ISOFORM Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036492">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="481"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="3"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR036492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR036492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0721761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="511" mass="55919" checksum="D38F252FBC0681AC" modified="2020-08-12" version="1">MTTLQPSTAASIEADVTTLRASFRQGKLKSLESRKRILRQIQKLVSENTPLFEEAIMKDLHRHPSELFLAEIAHVLSEVQEALDYLDDWAAPEKVSTNLANIPGTSRIVREPLGVCCIIDTFNYPISLALAPLIGCISAGNCGLVRLPPEGTCDNISAALASLIDKYIDADVVRYVVGGIEPNIAMLKHKFDLIFVTGGLTIGKIVARAAAEHLTPTILELGGKSPCIVDESVDLKLAAKRIAWGSFMNCGHTCVRPDYLLIHSKIADTFVRLLIDQLREFFGDDPQQSSSYGRIVNQGHTKRLVGIVESDRAFVIHGGKSDLADRYLAPTLLNFKSNFQAFEASASMQDELFGPVLPMVYYDQLDPVLDFINGRPKPLALYVFATNSRMIDTVMKGTTSGGFVANDTIVHYLNSHLPFGGVGGSGMGAYHGKHSFEAFSHKKSVLLRGSYLDLPQRYMPYTPSGFRVLKLALSPITRGQVRFALGTTIVTLAAIAFAFFQAKLKAKLTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W6S2</accession>
    <name>A0A6G0W6S2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_018892</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000363">
        <property type="protein sequence ID" value="KAF0721827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W6S2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002946"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020608"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF288">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="225"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0721827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="311" mass="34858" checksum="DD42DDD2FDFB652A" modified="2020-08-12" version="1">MTTRTTKSRCADNTLSEQDSVGCCVDVNAQSTMPLKTTDGKISSWKCSALMYASRVGHIDLVRLLLAQDHIDVNAKQEKVFTVHKSIWAFLAKQREEMKEQATTSDSQVRQLSREMLLSMRRGAILHFDLKVPDGFIISDGSQSQTLHWQGEVASVRYILQCTSSAPLDQVMFQTKIIVGSNIMILKSFLFVTSEAQTQMRNTSELQSIIELIPQQYEEIPYQDLNLRELVGQGHFGDAFRAEYKGKDVVAKTLRAQTFGESSDDIVQEFRHEAAVLSMFGHHPNIVPFVGASTDLSQPLALVTAYCRMEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W774</accession>
    <name>A0A6G0W774_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_018071</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000319">
        <property type="protein sequence ID" value="KAF0722996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W774"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0722996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="74" mass="8231" checksum="B605568AF7C775E3" modified="2020-08-12" version="1">MSARLTNFSKKWLSDPAIYPSVVVLTCAVAGLGSTVKRYKAMERATQDSSRGLPSQHPNAHHDLEQVDVLMMMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W7D4</accession>
    <name>A0A6G0W7D4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_017931</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000317">
        <property type="protein sequence ID" value="KAF0723060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W7D4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011096"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
        <property type="entry name" value="FYVE_like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="5">
        <location>
            <begin position="147"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0723060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="281" mass="31468" checksum="AE32D35E43476117" modified="2020-08-12" version="1">MYTVVDTDTDAIDIRWLSFKSPVRSVIKCRDMVPIEVQHRCVVDGRAGYVVGAASIKLGCCPNFRKSLGLIRTTVHRMGAVYLETDRPGILQVNRMVQINFGGSIPSWMVNLAQLARMRAMKHLDRFFQQQRLSAQTFLPAPHLVPKAARSRCFLCQTSFGLLSVKTQCQKCGQVMCRSCVNVWSLHISGFDTKVTVCSACTLVPRETTEISPIDTCLDAVQDYYHRLNRRPNPPSPIVLSPHGREEAPILLTSPSYDSAGSSPDDLMTSFTLYPNQLKWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W7E0</accession>
    <name>A0A6G0W7E0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_018713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000349">
        <property type="protein sequence ID" value="KAF0722076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W7E0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019730"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF132">
        <property type="entry name" value="PROTEIN-LYSINE METHYLTRANSFERASE C42C1.13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0722076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="237" mass="26714" checksum="328A21AA1849BA30" modified="2020-08-12" version="1">MFRESDDESSEGSSDDEDASPIAGESASDDSMTYESLNKSFSIILRQDRKKGIAHQLWPAATFLSHYLEQHTSEFLPQGTSVLELGAGIGLCGLVCHKLHASHVVLTDLPVAIPLLNTNIGLNCTTENVQAAVLSWGNANDLTQVVTQIPPSERLLCVAADCVYWENLFQPFFETVRALVVDHNVDVLLAHVKRWKRDERFFKLCRKHMHVDQLVEDISHDQDQRTIKRIYRITKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W802</accession>
    <name>A0A6G0W802_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Queuine tRNA-ribosyltransferase catalytic subunit 1</fullName>
            <ecNumber evidence="5">2.4.2.64</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Guanine insertion enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">tRNA-guanine transglycosylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_018551</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>guanosine(34) in tRNA + queuine = queuosine(34) in tRNA + guanine</text>
            <dbReference type="Rhea" id="RHEA:16633"/>
            <dbReference type="Rhea" id="RHEA-COMP:10341"/>
            <dbReference type="Rhea" id="RHEA-COMP:18571"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:17433"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:194431"/>
            <dbReference type="EC" id="2.4.2.64"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of a catalytic subunit and an accessory subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the queuine tRNA-ribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.64" evidence="5"/>
    <dbReference type="EMBL" id="VJMJ01000340">
        <property type="protein sequence ID" value="KAF0722258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W802"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014610"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008479">
        <property type="term" value="F:tRNA-guanosine(34) queuine transglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="entry name" value="Queuine tRNA-ribosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00168">
        <property type="entry name" value="Q_tRNA_Tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004803">
        <property type="entry name" value="TGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00430">
        <property type="entry name" value="Q_tRNA_tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43468">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43468:SF1">
        <property type="entry name" value="TRNA-GUANOSINE(34) QUEUINE TRANSGLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="tRNA-guanine transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 5" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-guanine(15) transglycosylase-like" evidence="6">
        <location>
            <begin position="35"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding; important for wobble base 34 recognition" evidence="5">
        <location>
            <begin position="316"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="114"/>
            <end position="118"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="381"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0722258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="402" mass="44800" checksum="F0DEDA9FB757DA0B" modified="2020-08-12" version="1">MAHRRVLPVPPASSFPAYSPRDFFRFEIVHESKKSKARVGRIHTPHGIIDTPGFVPVGTNAALKGVTQKQADDAGAQLMFANSYHLLLQPGPEIIREAGGLHKFMGRRRPIITDSGGFQVFSLAYGSVHEELKGKGKQNKYKTNDASAVIKIDESGVVFKSYRDGRRITLTPESSVQAQKAYGADVIIPFDELPPYHITADKLEESVLRTHRWEARSLMEHLKDVQQQAMYGVIHGGIDERLRSMSAEYITSLPFDGHAIGGSLGKNRDEMLELLNFLRPQLPDSKPIHLLGIADEPSLHACIPLGIDTFDSCYPTRAGRHGTLFSTTYGAFHIVRGKYARMDGPIDADCPCPACTEHSIGYIHHLFKAKEPTAMMLATLHNLTYMTRRMARFRSDILQDKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W8K7</accession>
    <name>A0A6G0W8K7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_017529</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000300">
        <property type="protein sequence ID" value="KAF0723626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W8K7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007729"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF349">
        <property type="entry name" value="AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="362"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="6">
        <location>
            <begin position="14"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0723626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="490" mass="53049" checksum="5A3F4FFE8350D51C" modified="2020-08-12" version="1">MGKPFLTLEDLKMCFSLFCCVYGVGTLSMPKNYASAGFVWASLALVFMAIVNIYATVCISKIMLVAPKSVRTFADLGEFSMGKTGRWLILITQMLTCIMVPIVFLVLGGSILTILFPKSYEDTTWIILMGISLLPVCLIPTLKEGAFAAAAGCLGTVLADAIALYLLVDNMEPASKGFTTPKPDVGFKQVAGVFGSLALAYGAGIVIPELQREHSEPTRMPRVIVVTMGLISVLFLTVAVTGVSFVGCQIPGNLLFSIAGSPTALGFTANRGGVILACLFMQLHVTIAFAVIMNPAFFILEGLFLGLHKHAFGTPEIEAGYDAAATPDGEKVSEALEEKEFNEHHDLDSKTYQAPGVYPKVAALRIVVVAACVAIACAWKDHLSDLLDFTGASCLSLCCMILPMIFYMKVLWNKIGALEKIWIVIAILVCLFLAVYESIQTGKVLFKSSTKQPDTWDKIKFSYCPAGSSYQRIVYTNVSYHANYTQTTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W8L0</accession>
    <name>A0A6G0W8L0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_018382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000331">
        <property type="protein sequence ID" value="KAF0722545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W8L0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019055"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051729">
        <property type="entry name" value="Opine/Lysopine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003421">
        <property type="entry name" value="Opine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38015">
        <property type="entry name" value="BLR6086 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38015:SF1">
        <property type="entry name" value="OPINE DEHYDROGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02317">
        <property type="entry name" value="Octopine_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="23"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0722545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="436" mass="48722" checksum="28711C743C81BFF9" modified="2020-08-12" version="1">MTLSVATARAQLKKNVKSSTTSPVVCICGGGNGAHVAAGYLASKGIRVHVLTRQPELWDEEVRITTKGSSWEDKGEIVGRLTMVTSNAKNAIPTADIIFVAAPANAHPPILEKIAPYLKPGAILGALFAQGGFDWAAKRALGTDGLNRLHLLFGLQNIPWICKATTYGKEAKIIGPKKSLYVAAYPVERKEIAARCMEDLFDIPCATVANFLNLTLTPSNQIIHPARYYAIFRDWDGKKTYTKKELEARRGLTLYADFDEFSAEQLSMLDNELQQVKYALLQRFPALDLSDVLPMDARVVKQYGDDVADRSSLKAIFATNLGYAGCNTPLKEVSPGAFHPAVDSRLFWEDIPFGLCILKNMAEMLGNFPTPRIDFMIRWHQQYMQVQFLNDDNQLNPRELWRTGAPNKYGIHDIFELVETSLPREMRGYKHPRSRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W8V7</accession>
    <name>A0A6G0W8V7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_017410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000296">
        <property type="protein sequence ID" value="KAF0723738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W8V7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015221"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0723738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="255" mass="28218" checksum="F4686F1810DD8E1B" modified="2020-08-12" version="1">MDPRRQEDLNLGPDHPDAFIAGSERDPSQTNTMTESAIVTYTESPLTTLRKRDLEYRRLHHANSPEQRDPEKRSRQLPAEYSDEDMGADTKSDLAPSPALDASEAGPSDHSSSELSFEPRSSLEELPSWESYDDTSFPAQDLIHYDGDPVSTINVPFDDAFTPEDGRIVPFSHSTATLTPTSSAITRTVTTVVSRTISETINARTMPQLFQLPEHDELGLVVTGHGNHANHHSTQRPALTLDTSPTSFRAHQSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WBW8</accession>
    <name>A0A6G0WBW8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_017431</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000296">
        <property type="protein sequence ID" value="KAF0723759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WBW8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021783"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF288">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="190"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0723759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="430" mass="49518" checksum="FF637EFC7D6B594E" modified="2020-08-12" version="1">MLNESTVHAPAILLVLSEIRNYWEKSLQTIQVWKMQVSSNQNQETMKEIRRNITQLQQRLIEASNGLNVLLDIQVVGDIDDIKNDIGTLMKSMLGISSSLDSISKKSEPRRQEDSFVELTIQMQRGLEYYENQVALGNIGRLVDFENHIERCRDQIDNTVRLIRNLTKIPKNFCLDKNSSWMLCSDDVEIDESNILGQGGFGTVFKGKYMGQDVAVKRFNQFHVTDSAELEKMIATEVKAWKDISKEPNILTLIGVCTKIPKPILVSELCNTNIRHYVRDWPEMLLPMVYQFAQGLASLHNADIIHRDIKGDNVLITYQKTVAIADFGLSRTVESLEITKTGKRLGTLNWMSPEQFLTPRKVTTKTDVWSFGMTLWEILCNNFPFRDCSEHEFVDEIYKKEYDRPEKPKKTKSQPLTLTRWIQSTNLYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WCH1</accession>
    <name>A0A6G0WCH1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_016406</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000253">
        <property type="protein sequence ID" value="KAF0725008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WCH1"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0725008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="148" mass="16940" checksum="E59F9E2A16D837C1" modified="2020-08-12" version="1">MARRDWALQKIVPLLRRWKQDGIEIEGVSKPLKVRNKDLGVSWENYLVAGSCITSSSRRSIDISTHINVPCLKRKSMGHPSRKWRQTSLDWKRDLTLGCFLQDHQLSVVDSGHILGNPYIQAMVSRQTSNRWSSRGGFTSIVDKHLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WCT9</accession>
    <name>A0A6G0WCT9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_016240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000246">
        <property type="protein sequence ID" value="KAF0725275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WCT9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014679"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF57">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="1">
        <location>
            <begin position="129"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0725275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="308" mass="35746" checksum="14626EE473A331EF" modified="2020-08-12" version="1">MTLKRAKERARTCTHVIKWIKKNHREWLRSHLSDKSNGYKSLLRLLQRFSHRHGFSRQRPGKLKLKQDVLVSIRDEFAADFHRQYEAYDDCSRYNVDETGIYYEMPPRIIWSIRGGDAKIFAGEKNAYRMTAVLTIRGDGKKLPLMFIIRGKPGGRIATNELPTYPPGHFYAVQEKAWMDSVVWRQYLVDVLEQDIEGPSVVMLDNFEPHVSVSSYKAINDMGCHVCALPPNSTSVYQPLDVGIMAPFKRHMRDIWLDEDDIDDDETEDLESPTATKKRLALINRSILAWGRITDDEICRSFEKVLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WDB6</accession>
    <name>A0A6G0WDB6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_016211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000244">
        <property type="protein sequence ID" value="KAF0725314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WDB6"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0725314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="95" mass="10583" checksum="C5DADC2DEC050218" modified="2020-08-12" version="1">MLALLRAVRAAPRVASLSTFEVSRSFPPTAPTLPVRNAILFQPDTALDAVLENMRLSSEPIVGMQLLGRNSRKPKKANHGKRPCSHVRRRSKRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WF04</accession>
    <name>A0A6G0WF04_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cellulose 1,4-beta-cellobiosidase (non-reducing end)</fullName>
            <ecNumber evidence="3">3.2.1.91</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_015537</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains.</text>
            <dbReference type="EC" id="3.2.1.91"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 7 (cellulase C) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.91" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000224">
        <property type="protein sequence ID" value="KAF0726134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WF04"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012169"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016162">
        <property type="term" value="F:cellulose 1,4-beta-cellobiosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.100.10">
        <property type="entry name" value="Glycoside hydrolase, family 7, domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001722">
        <property type="entry name" value="Glyco_hydro_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037019">
        <property type="entry name" value="Glyco_hydro_7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006970">
        <property type="entry name" value="PT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753">
        <property type="entry name" value="1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753:SF2">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00840">
        <property type="entry name" value="Glyco_hydro_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04886">
        <property type="entry name" value="PT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00734">
        <property type="entry name" value="GLHYDRLASE7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="225"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="357"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="311"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="376"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="410"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0726134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="428" mass="44989" checksum="814FC43BB8158103" modified="2020-08-12" version="1">MDIWQSNSISQAYTSHPCIVDGQTRCSSPTECGDDATNNRFDGVCDKDGCDFNPYRMNSHDFYGPGSNFKVDSTKPVTVVTQFITDDNTANGNLVEIKRFYVQNGKAIDNSAISWTGIDPVNLLTDKVCDQAKTVFGDTNDHSKKGGLKVMGDALKKGVVLTMSLWVDYAANCLWLDSTYPVTKNPSVPGAGRGTCATSSGVPADVLAQSGSATVKYGNIRVGDLGSTTTVTPPSPSPSTPSVTPLRSPAPIADSSETPEPTDAPSDSPTDAPSDSPTDAPSDKPTDAPSDDPTDSPSNEPTDTPSEDPTDAPSDSPTDAPSDDPTPAPSLTAPSDSIVPIYYQCEWNEWCSQCIAPESTFPSTDNPSDALFEPTDAQTDVSTDAPSDSPSDEPTNDPSNAPTEAPSDIPSDEPSDEPTDEPTDVPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WFI9</accession>
    <name>A0A6G0WFI9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_016047</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000241">
        <property type="protein sequence ID" value="KAF0725484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WFI9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002571"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000036">
        <property type="entry name" value="Trypsin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF98">
        <property type="entry name" value="FI18310P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0843">Virulence</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="11">
        <location>
            <begin position="58"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0725484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="310" mass="32857" checksum="77E7D6E31E62A3CC" modified="2020-08-12" version="1">MSIVTVVALLCLLVSLKTISFSVQFAILHHYHMDMIAVFAVLGLVLTATAAATVHIDITGGESVASDKVPSYIAMLTADLPSTGVACTGSLISPSYILTAAHCASTIQWALLGAYNASGSDAKERIRLVKRTNHPKFEPIDLYYDFALYQLATPSKLAPVAISWEEDSFNAPGVIAWIRGYGQTNSQGAQPTALQQAQVQIWSNDDCSRAENGRKVDRVSNICAGGSKQDTCNGDSGGPLTVMKNGQEQLIGVTSWGSLACAVPGIPGVYARISAAKSFINSVIPRLECIVRPSLKFSPLSYALAEGCEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WFV1</accession>
    <name>A0A6G0WFV1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_015681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000229">
        <property type="protein sequence ID" value="KAF0726017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WFV1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001678"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047574">
        <property type="entry name" value="AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039683">
        <property type="entry name" value="Lsm12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019181">
        <property type="entry name" value="LSM12_ABD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13542">
        <property type="entry name" value="LSM12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09793">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00995">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52001">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AD" evidence="1">
        <location>
            <begin position="88"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS52001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0726017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="183" mass="20066" checksum="C6F9A6621913848A" modified="2020-08-12" version="1">MADVVKVDLPVKQSEGVVTSPVALGTWVQVKTSPDGLVIEGSIFTLDPMSGFLVLEGVDKTHMIQIESIESVTVDESSRERPTAARSAVISEEELRKLEIKTREQAEKAIASIGKNVSPIGQAIFDALSKTMPCEWEDQNIRVMQVVVSPPYDSSSCTGTNQAMLDRMKKVLDGVHRNLRLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WGL4</accession>
    <name>A0A6G0WGL4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_015400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000219">
        <property type="protein sequence ID" value="KAF0726285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WGL4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021542"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0726285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="530" mass="59125" checksum="F4174A0C7800CFD3" modified="2020-08-12" version="1">MHRHGMATSQSSSSLVLKEQDENDDSFHRPYTESAILIESMSTPSYCRSDASPRSFLFPLSSDIAMATEDANVHHAVRIIERLPRHDASNSSITSGSTTSTLFPNTALSSSYSTNPWSNSYSKQSSSDFDSVSSFELPAVTDNEDDGYEESSYAQIMPPVTMASESGSKPPPFYYDEASYEEHVNIWASRVWTSGSGKEDDLETFLQAMDKARAQLSAHQEYASSQSTAMLHAIEETTEAAQTLSRGHLSSTVPLVAPSLVASSLSSGWEVGPAPPPLSLSTTSPSILSPILVAKLHSSGLRWFDQVFLLPHEPLRRALRKVRRFVTLEHMPVEAAESKKAAFFSWFDQLRLYVQTQCHIKSTVLKAIIVGVNPHMAQVLDATTHSYPAVLEIVDAVVFFQSHHAVNDDVDPLQGWASFVLQLAEYLSTLEHVLLAMLDRDEIDFGHALASTFDEESYARLVQKKIEVALPNHAKRVMVPWMLESCNTFGGSTEHWQWGWWSKWLLEHSWRKYYEANVVAPLHVLEFGHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WGZ9</accession>
    <name>A0A6G0WGZ9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_015323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000216">
        <property type="protein sequence ID" value="KAF0726435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WGZ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019072"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35213">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0726435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="198" mass="22167" checksum="74595B592599AF73" modified="2020-08-12" version="1">MKKTIEELSPVGKPAPTAQRCGPWSEAEVAFATRLSDDFKAGLIPDVPNGIPLRKWLSEKLNCTPMRLSKKFDKTSGVLGMCRYTCNVVSIASMSAEKSRRRQEQLELLEAAFRKSVEEEQQKLNEFHIHQTQKQAKKRKKTSPSSTNSTKDLLKKMKAEPPHNPTDVSVGFLLLELHKSIVPSLPPLPPPPSIKEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WHV1</accession>
    <name>A0A6G0WHV1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha-ketoglutarate-dependent dioxygenase FTO</fullName>
            <ecNumber evidence="4">1.14.11.53</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">mRNA N(6)-methyladenosine demethylase FTO</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">tRNA N1-methyl adenine demethylase FTO</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">Ae201684_015040</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>N(6)-methyladenosine in U6 snRNA + 2-oxoglutarate + O2 = adenosine in U6 snRNA + formaldehyde + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:57900"/>
            <dbReference type="Rhea" id="RHEA-COMP:13573"/>
            <dbReference type="Rhea" id="RHEA-COMP:13574"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74449"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in U6 snRNA + 2-oxoglutarate + O2 = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in U6 snRNA + formaldehyde + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:57904"/>
            <dbReference type="Rhea" id="RHEA-COMP:15030"/>
            <dbReference type="Rhea" id="RHEA-COMP:15031"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:85958"/>
            <dbReference type="ChEBI" id="CHEBI:85959"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in mRNA + 2-oxoglutarate + O2 = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + formaldehyde + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:57896"/>
            <dbReference type="Rhea" id="RHEA-COMP:11518"/>
            <dbReference type="Rhea" id="RHEA-COMP:11519"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:85958"/>
            <dbReference type="ChEBI" id="CHEBI:85959"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>an N(1)-methyladenosine in tRNA + 2-oxoglutarate + O2 = an adenosine in tRNA + formaldehyde + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:54576"/>
            <dbReference type="Rhea" id="RHEA-COMP:10242"/>
            <dbReference type="Rhea" id="RHEA-COMP:12312"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74491"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>an N(6)-methyladenosine in mRNA + 2-oxoglutarate + O2 = an adenosine in mRNA + formaldehyde + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:49520"/>
            <dbReference type="Rhea" id="RHEA-COMP:12414"/>
            <dbReference type="Rhea" id="RHEA-COMP:12417"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74449"/>
            <dbReference type="EC" id="1.14.11.53"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="17">Monomer. May also exist as homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fto family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.53" evidence="4"/>
    <dbReference type="EMBL" id="VJMJ01000207">
        <property type="protein sequence ID" value="KAF0726784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WHV1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003312"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035516">
        <property type="term" value="F:broad specificity oxidative DNA demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990931">
        <property type="term" value="F:mRNA N6-methyladenosine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040014">
        <property type="term" value="P:regulation of multicellular organism growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042245">
        <property type="term" value="P:RNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1470">
        <property type="entry name" value="FTO C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032868">
        <property type="entry name" value="FTO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024366">
        <property type="entry name" value="FTO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038413">
        <property type="entry name" value="FTO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024367">
        <property type="entry name" value="FTO_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31291">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE FTO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31291:SF2">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE FTO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12934">
        <property type="entry name" value="FTO_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12933">
        <property type="entry name" value="FTO_NTD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01223">
        <property type="entry name" value="FTO_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-ketoglutarate-dependent dioxygenase FTO catalytic" evidence="24">
        <location>
            <begin position="85"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="23">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00046452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="SMART" id="SM01223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KAF0726784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="512" mass="58484" checksum="D0ADF1796FDD5769" modified="2020-08-12" version="1">MDTKERKKLERLKKKLKAQKKKEASAPKPASTAPSVPAKPAPNSLKRPAPEHPTAPATKKQDTTTKAFPVPSPYSGPEKFLTPSHPQFNEILKRSYVGFVHEPGTTLPRDFHEGMRSAFEKLRDNEYFQYDVVMAGGKHLSRTFVRRTLVGDYGITYKYLGLRIFAHVWDKPHCAPVFKSLYQLNQRMIERTKRSMKPTPPLCDYNLTLINYMEPDNPMLGLKADPTYDMGKVSVSWHADSSLQDYSSIGVYHSLLGNKKKKAPCDWRIAMRLSPEVPGAATTPPLVLPTDGGDVYYLNGDFNHFHQHMVLAGTAVRVSSTHRVAVTDEDTLQYIQGRVARALKSSANGNSPFRDGEVDAVREEQATLTVVEMDWIRQYWIQGVKHDELHTDWQGPMRKLEASWLVLEERTKTLVDALLKTQDIEHLKVLKAVLEGLRARQAGRDQFVHRMRDKVFKRIHADFQPTERPTWKSGILPKDLTDVIAKLNAHKEELEKEKKKQWKANHKKQQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJB5</accession>
    <name>A0A6G0WJB5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_014588</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="VJMJ01000198">
        <property type="protein sequence ID" value="KAF0727328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJB5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011070"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044322">
        <property type="term" value="C:endoplasmic reticulum quality control compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904380">
        <property type="term" value="P:endoplasmic reticulum mannose trimming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044674">
        <property type="entry name" value="EDEM1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012913">
        <property type="entry name" value="OS9-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679:SF6">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07915">
        <property type="entry name" value="PRKCSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026130136" description="alpha-1,2-Mannosidase" evidence="11">
        <location>
            <begin position="20"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="12">
        <location>
            <begin position="47"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="677"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1016"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="679"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1022"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="413"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="508"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="530"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="614"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0727328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1057" mass="117809" checksum="3DF9F58A983626F6" modified="2020-08-12" version="1">MRRAVPIVAAVLSVHSTLSSTPSSNLATELDNQDAFKGLIDTSSLKDICRTHYVRGDWWHYEWCHEKHVRQFALDRVGGEETDSISLGTFSRKFQSVYEANGDERAYTSHLFLQGDMCHSGQPTSQVARNRSTEVRFTCCTFRPSETYIESVTEPRLCDYLVTVCTPDACHNPPPTSVSDFNATNQELADTVKRMFYHAYDSYMTHAFPLDNLKPMSCSGENFELGKIPMLTLIDTLDTLVVFGDHAEFHRAVELVTSHASFDLDTEVSVFETTIRVLGGLLSAHLFAIDPTLNIYANETYSGGLLKLAVDLGDRLLPAFLTKTGIPYGTVNLRRGVPTDETPIASTAGAGSLTMEFTMLSVLTKNPIYANAARTAVRGLFVRRSALGLLGKHIHAHTGEWTETLSGPGSNSDSFYEYLIKMYTLYGDTESLSMFDAVYSAVMEHNKHGDWYGDVNMWDGCSTTQSFTFDNLVAFWPGMQSLLGEFKLSSRSLNAFYQVWQKYSFLPEQFDVVRWRPKKAQLNGYPLRPELVESTYYMYRSTRDPSWLQAGAIAVESLERYSKTTCGYASIADVETKTQEDTMPSFFLSETCKYLYLLFDDKNFMHQRNYVFTTEAHPFPVLPTDQVEPILQASPALQSSVLSDERRMCPVLPSPFFLDLRFRRQFTDGFELVRPRCRPPTSSPSTKRPVAPSTSSVLHGGKELGEFKVEQLVGGFRARRLSKNSQWMKVSNLGDPKIVVEYQREGSTTSEFRVYDFPEKLTRRCRLLLADGTTISCSAALFGLTSDDSISISIENAPAIYGSPENGCSPLAEDSSHNRIIILMRGQCYFEAKAKAARKAGAVAVVVINTDTKEEMMIMGRSFDVGVDDLDIPAVMVPIAAEAKLREAVANNEPISLEYGIVTAKEFPSVEGSQDDMTVWGPDGWGLRLAAKNKGHANKAPLWTISIADAQQDNDTSEDRGDDDGINDQLLEKLKFLGFSDEQIALVNSDDGNVRMEALVDGLRALGLDSLADQIQSTNSEQDSDIEDTEFDDQENADTQEDDFIEDVLTEVLADES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WKL3</accession>
    <name>A0A6G0WKL3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cellulose 1,4-beta-cellobiosidase (non-reducing end)</fullName>
            <ecNumber evidence="3">3.2.1.91</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_014252</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains.</text>
            <dbReference type="EC" id="3.2.1.91"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 7 (cellulase C) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.91" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000188">
        <property type="protein sequence ID" value="KAF0727817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WKL3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008719"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019546"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016162">
        <property type="term" value="F:cellulose 1,4-beta-cellobiosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.100.10">
        <property type="entry name" value="Glycoside hydrolase, family 7, domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001722">
        <property type="entry name" value="Glyco_hydro_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037019">
        <property type="entry name" value="Glyco_hydro_7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753">
        <property type="entry name" value="1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753:SF2">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00840">
        <property type="entry name" value="Glyco_hydro_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00734">
        <property type="entry name" value="GLHYDRLASE7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0727817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="398" mass="43864" checksum="326CA48FC0D86271" modified="2020-08-12" version="1">MPRWTKDCDAQRALEKLIDDHTITAQTKAQTAYNLDTDIFHQFNFPSFQKHFDSTTRMRFGQSLGKRRAPAPLDDDTAVPFLQPKPAVESPMPVESVSNRIKGEGLEGLVTEYYNITTKTKCVVVVLTPPCGATTTCEIDEADPSILRVTWTWTDSICDPTSLFKSKMANPTTETILMTDGKAKNSPNKASATYGTGYCNAQCPHDIKFINSEADAKNWVPRTGGQNSGSGQHGSCCEETDIWESNSISQASTSRPKTVTGQYRCLSPTECGDDATGNRSDGVCDKDGCDFNTYRLNDHTFYVPGFNFNVDSSKLVTVVTQFITIDGNLVKIKRLHVQNSKGIDNSAFNWPLCNQAKTVFGDAKGHLKRRELKAMGDAVKKGVVSTMSLWVVYTANCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WKY7</accession>
    <name>A0A6G0WKY7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_014068</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000184">
        <property type="protein sequence ID" value="KAF0727957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WKY7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004712"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34494">
        <property type="entry name" value="PROTEIN CBG25024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34494:SF1">
        <property type="entry name" value="PROTEIN CBG25024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0727957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="203" mass="20252" checksum="149B2190C6343521" modified="2020-08-12" version="1">MGNAQAIPIVGEVVTCAEALGKTVAAGACAIAGDSKGADKLIKSAGQSFENYADLNPIVANTRVAIAAANNDDREVQRLCKRQEDAWIGIVDSTPVVGHVKGVVHLALGDNERAEACLMAATRSALVVAASIATAGAGAVACGTATMLAGTGTDAVTTGINSASKGEFVPVGMIAACDRAAKTGDVIDVFECVAIPVGDALDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WL69</accession>
    <name>A0A6G0WL69_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_014114</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000184">
        <property type="protein sequence ID" value="KAF0728008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WL69"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0728008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="148" mass="17055" checksum="5949481B51FD0705" modified="2020-08-12" version="1">MDGPDHRWTQCFRRVYDVLPTRGSVAITYNVAILSVKSQKTTASTQYIRDVSGHPSAHLRKNPQSIRTVGKLYDGFFIESKSDGVSILIHMEYLYVKHKVQIDVKTPNRSTLNPAALFPELCTIELSPLTNICYQKKRYWNEWMRYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WLA9</accession>
    <name>A0A6G0WLA9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_014037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000182">
        <property type="protein sequence ID" value="KAF0728051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WLA9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019632"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0728051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="163" mass="17784" checksum="3AF556CB3731D1BA" modified="2020-08-12" version="1">MYDYFSVLPGLSVGSLMTTDPDAPEPSEDDTASDDGENSDLELVSENEPHEPQGEQPTMSSKEAASERIELKTFSRRRVHSAAQDKLKKYTTQADSLLRGLEAVGSGLSSLGSALVSKQGNPQDDILRAINAQTAIMERQANAIERQGNQIEQLLKYLTSQND</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WLL9</accession>
    <name>A0A6G0WLL9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_013879</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000180">
        <property type="protein sequence ID" value="KAF0728227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003018"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08056">
        <property type="entry name" value="MPN_PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13838">
        <property type="entry name" value="RNase_H_like_Prp8_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.230:FF:000003">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000002">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1570.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.40">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012591">
        <property type="entry name" value="PRO8NT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012592">
        <property type="entry name" value="PROCN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012984">
        <property type="entry name" value="PROCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027652">
        <property type="entry name" value="PRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021983">
        <property type="entry name" value="PRP8_domainIV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043173">
        <property type="entry name" value="Prp8_domainIV_fingers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043172">
        <property type="entry name" value="Prp8_domainIV_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019581">
        <property type="entry name" value="Prp8_U5-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042516">
        <property type="entry name" value="Prp8_U5-snRNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019580">
        <property type="entry name" value="Prp8_U6-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019582">
        <property type="entry name" value="RRM_spliceosomal_PrP8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140:SF0">
        <property type="entry name" value="PRE-MRNA-PROCESSING-SPLICING FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08082">
        <property type="entry name" value="PRO8NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08083">
        <property type="entry name" value="PROCN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08084">
        <property type="entry name" value="PROCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12134">
        <property type="entry name" value="PRP8_domainIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10598">
        <property type="entry name" value="RRM_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10597">
        <property type="entry name" value="U5_2-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10596">
        <property type="entry name" value="U6-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="MPN" evidence="9">
        <location>
            <begin position="2128"/>
            <end position="2259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0728227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="2361" mass="275028" checksum="374C0186B05F91F0" modified="2020-08-12" version="1">MGVPPPPPLPQGSYGNAPPPPPPPPGQPVGFFPAPPPTMPPSYDEEAQQYFREIEERSRRWAKRQTKRYGDKRKFGFVESTKDDMPAEHVRKIVRDHGDMSSKKFRHDKRVYLGALKYVPHAVFKLLENMPMPWEQVRDVKVLYHITGAITFVNDIPWVVEPVFIAQWGTMWIMMRREKRDRRHFKRMRFPPFDDEEPPLDYGDNILDVEPSEAINMELDEEDDAPVIQWLYDPKPLIDTKFINGPSYRKWKLPVPIMSNLHRLAGQLLSDLIDPNYQYLFDKESFFTAKALNVAIPGGPKFEPLYRDLDQDDEDWNEFNDINKIIIRHQIRTEYRVAFPYLYNSRPRAVHMQPYHASALCYVKAEDPDLPAFYFDPIVNPISQFRVGAKKVEEVIDEEEDEFQMPMGFAPILSDAPLYTEHTASGIALYWAPRPFNLRTGKTRRAVDVPLVNKWFQEHCPPNQPVKVRVSYQKLLKCWVLNHLHSRPPKALNKKYLFKSLKSTKFFQSTELDWVEAGLQVCRQGYNMLNLLIHRKNLNYLHLDYNFNLKPIKTLTTKERKKSRFGNAFHLTREILRLTKLIVDAHVQYRLGNVDAFQLADGLQYTFAHVGQLTGMYRYKYRLMRQVRMCKDLKHLIYYRFNTGPVGKGPGCGFWAPAWRVWIFFLRGIVPLLERWLGNLLARQFEGRHSKGIAKTVTKQRVESHFDLELRAAVMHDILDMMPEGVKANKSRTILQHLSEAWRCWKANIPWKVPGLPAPIENMILRYVKSKADWWTNVAHYNRERIKRGATVDKTVCKKNLGRLTRLWLKAEQERQHNYLKDGPYVSAEEAVAVYTTTVHWLESRKFAPIPFPPLSYKHDTKLLILALERLKENYSANNRLNQSQREELGLIEQAYDNPHEALSRIKRHLLTQRAFKEMGIEFMDLYSHLIPVYEIEPLEKITDAYLDQYLWYEADKRHLFPSWIKPSDSEPPPLLVYKWCQGINNLNKVWSCDDGECVVMLESKLEKVSEKMDLTLLNRLLRLILDHNMADYMTAKNNIVIAYKDMMHTNSYGLIRGLQFGSFIFQYYGLVLDLLLLGLTRASEIAGPPQFPNEYLTFKDTETETHHPIRMYTRYIDKIYVLYKFDAEDSRDLIQRYLTEHPDPNNENIVGYNNKKCWPRDARMRLMKHDVNLGRATFWDMKNRLPRSMTTLEWDHSFVSVYSKDNPNLLFNMCGFEVRILPRIRALEDEFTHKDGVWNLQNELTKERTAQAYLRVDDDAIKAFENRVRQILMSSGSTTFTKVANKWNAALIGLMTYYRESVVQTQELLDLLVKCENKIQTRIKIGLNSKMPSRFPPVVFYTPKELGGLGMLSMGHVLIPQSDMRYSKQTDGGITHFRSGMSHEEDQLIPNLFRYLQPWESEFIDSQRVWAEYALKRQEATVQNRRLTLEDLEDSWDRGIPRINTLFQKDRHTLAYDKGWRVRTDFKKYQVLRQNPFWWTHTRHDGKLWNLNNYRTDMIQALGGVEGILEHTLFKGTYFPTWEGLFWEKASGFEESMKYKKLTNAQRSGLNQIPNRRFTLWWSPTINRANVYVGFQVQLDLTGIFMHGKIPTLKISLIQIFRAHLWQKIHESLVMDLCQVFDQELDALSIENVQKETIHPRKSYKMNSSCADILLFASYKWQMGRPTLLHDVKDNADGSTSTKYWIDVQLRWGDFDSHDIERYARAKFLDYTTDNMTIYPSPTGVLLAVDLAYNLYSGYGNWFTGCKPLMQQAMAKIMKANPAMYVLRERIRKGLQLYSSEPTEPYLSSQNYGELFSNQIIWFVDDTNVYRVTIHKTFEGNLTTKPINGAIFIFNPRTGQLFLKIIHTSVWAGQKRLGQLAKWKTAEEVAALIRSLPVEEQPKQIIVTRKGMLDPLEVHLLDFPNIVIKGSELQLPFQACLKVEKFGDLILRAIEPQMVLFNIYDDWLSTITSYTAFSRLILILRALHVSQDRTKLLLRPDALTITQDHHIWPSLTDEAWLKLEVSLKDLILNDYGKKNNVNVASLTQSEIRDIILGMEISAPSLQRQQMAEIEQQAKEQSQLTAVTTKTVNVHGDEMVITTTSQYEQHSFASKTDWRVRAISATNLHLRTNHIYVNSDDIKETGFTYVLPKNVLNKFITISDLRTQIAGLLYGVSPPDNPHVKEIRCIVMPPQLGTHQSVTLPTTAPSHEYLDTMECLGWIHTQPNEAPHMPPQDVTFHSKLLSENASWDGEKTITITCSFTPGSCSLTAYKLTPAGYEWGKTNKDTGPSPPGYLHSHFEKVQMLLSDRFLGYYMIPDEEVWNYNFMGVKHTASMKYDVKVGNPKEFYHEVHRKTHFFNFSAMDTVEEGEEESQRNLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WM38</accession>
    <name>A0A6G0WM38_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_013736</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000178">
        <property type="protein sequence ID" value="KAF0728371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WM38"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005615"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000997">
        <property type="entry name" value="Multidrug resistance-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="326"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="99"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="416"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0728371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="753" mass="83770" checksum="2435E18CAA9D598F" modified="2020-08-12" version="1">MTDFVAVKSPQELIDETIPWSQQRHPLETAGWWSYLTIGWMNALIRKGSKAPLTDEDIWPMAQGDSVDTLYCQVMRYWKTEQKPKIHAVLWRAFTYRIVVSFVLFGLYALLSLLQPIAVKSMMQFLQHDALTKSALGPTNGYVLALLLFIISLVSVCIMDFAGFYAVHLASNMKSVVSHMVYLKTLALSGKSKSRFSSGEVVTMSSVDVERINLGFSLCHWAFLSPIMLVIIYIMLGFELGVLATLIGGLAMAACMLVGFTSAAKVGHYRQSILKVQAERVKLTNEVLQGIRVVKLYAWEISLQELLNNIRLRELSCLTKYHSLRIFNGVVLMVAPVLSLAFCLMVYVARGNELTTQVAFTALAYMNITRQPCSVFSVSIIGSTEALASCRRLTEFLNADEVDEVEHADPAHKAIVEISQGEFSWDWVTPTLKNINLQVKPNTLTMVVGAVGSGKSSLLSAILGDIHATSGTRNVHAKFSYVSQESWIQHASVKQNILFDSALDDELYRQVVAACQLHRDFSMLPKGDETEIGERGLNLSGGQKARVSLARAIYHQEADVYLLDDPLSALDVHVANSVFRDCVRGLLGGKTTVLVLTSHYHLLSHADRILLMSDGSIIGDGSYDDIVAKFPHLMNMMPATKVTSVEDQEEQQEDDKKTAKSESTLVAKEDNVKGQISWTSYKSYLGASGYNAYLMAFALTMLYTISQVALSMTDWVLDPYSRLWLGLRRFVRRVDGLSLRPLYVCALDCNPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WN30</accession>
    <name>A0A6G0WN30_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_013499</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000173">
        <property type="protein sequence ID" value="KAF0728756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WN30"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005869"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05123">
        <property type="entry name" value="STKc_AGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045270">
        <property type="entry name" value="STKc_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="72"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="10">
        <location>
            <begin position="326"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0728756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="394" mass="44504" checksum="D945443ABF20A372" modified="2020-08-12" version="1">MDICIRWIQDDAKTVELPSAKTCPDAFRRWKHVKLWLRFALHSWQMKNLTAPSSKEETSESTTTPDAVREVYEPLQVLGKGAFGVVVLSRKASTNDLVAIKSIDKSKVCPEEAARLMTECEILRRTNHPFVIHLERAFESPTHYHFVLEYCPGGDLYGLLEERHHLEVPLVLFYTASIVSALLYMHQVCGICYRDLKPENILLDAKGFVRLTDFGLARQDMHADTTTFSFCGSVDYMAPEVILGCGYGQAADVWSLGCVVYEMLTGLPPFYTTQGRRVLFDRICRGHVDYPDNLPSDACSFIARCLQLDPTKRGTIEDLLDHPFLDSVDWYQLAIQQVPVPYVPSLDSMDDTHHFDNQFTSEPPPVDKLVDTVSPFGTFDWSRPSPVVTSSTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WP97</accession>
    <name>A0A6G0WP97_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_013193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000167">
        <property type="protein sequence ID" value="KAF0729216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WP97"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018778"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0729216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="126" mass="14617" checksum="09A1E93715C70EE6" modified="2020-08-12" version="1">MGKHTRQFLQNALGRPTPPITIRSTMVDQPDGTQKYSENKADVMAALQNLLDNWIPPTERTERPTHLSTLSPAELPQAPRFVREWLLHDMHQPEHITPGFLHEGQCTWDTYVYTPDTQEHCDRYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WPC9</accession>
    <name>A0A6G0WPC9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_013184</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000167">
        <property type="protein sequence ID" value="KAF0729207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WPC9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003688"/>
    <dbReference type="OrthoDB" id="165382at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF9">
        <property type="entry name" value="MAGNESIUM TRANSPORTER NIPA8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0729207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="320" mass="35147" checksum="A8AA259664FD38A4" modified="2020-08-12" version="1">MVGLVGWPLGLMLSFLASIIGVLGKIMVKLSYQPKLSPQSTEARFWWGSGMVLVVLVNPVLCITAFKFAPQSLLAPMGGMCIVWNTVFSPYVLSEHLRRQDIVGAAIIFLGCVVVGGVGSHETHDIPIDELASHFTSPLFLVYITAYITLVIGLLRQAYPALLQVWDGYTAYASTYTTTCCRVSLASLAGSISGQMYCMTALLRLMHNEPKVVFSTPLVYFVAVGALTFALSGLYMMNLALKLYDALFVIYIYEATLMLGGAVSGICFFDDMKDLGMWHWVSYGFGILTILIGIFVIAHGERQPRQPYLDDLHGVKQTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WPX4</accession>
    <name>A0A6G0WPX4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">CSC1/OSCA1-like 7TM region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_012931</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000164">
        <property type="protein sequence ID" value="KAF0729430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WPX4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008912"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF5">
        <property type="entry name" value="RE44586P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="399"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="495"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="528"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="556"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="610"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="663"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="11">
        <location>
            <begin position="22"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="12">
        <location>
            <begin position="180"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="10">
        <location>
            <begin position="402"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="301"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="267"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="313"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0729430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="707" mass="78873" checksum="224D1E5F7449EF76" modified="2020-08-12" version="1">MPTPPPITSFAPPAHGGASSVVLTGVRIYLPLLVGCLLLFELLRKAFPNVYNCKMNSVPTAFARWIPYVWRVSDDEIMEASGLDSLIFLRFLRVGKHLAAFAIILSIGLFPAYSSKKLLTEEDFLDRLSISGLPRNDNRLWATIFAAIAMAFFTMFCIARECQAYKERRHQFLAQQGTQQYSVLVDEIPLHLRSHTALKRYFNTLFPSQVQFCYIAVECGDLERLVSMRQNVRNNLEHARVVLAKTSRRPTHLEWHGGCSFERVDSIATYERALDELNDNVALSIREIEAQQKHGSFYFNSTHLPDTSDLPPQVSNETTPPNTVNESTPLLKDTPSYSIPDLTASNVTFVTFSTLQAANTVQQIVHSPQPHEMKIYEAPPSEDIVWENVGTFHYEQKQLWILIVIAATSTLILFWTVPTTLVVVLSSVDSLRRVIPHLNDLLTQFPWLESFLQQLSPLGLVVMNSLAPVLLRLFSYGEGHVALNAIEAATFAKVVAFQLVQTFFVASVAGSLSAIADKIQMIIEQPLQIIPMLGSSVPGQSTLFVSFILVQTGLSLMLQLLRVVPIFLGGIYWLFAPKLTQRERSAPWLGLTPATTSPKLDVTTPLAQHFLVFLLVLTFAPLAPIVSVVGGFFFLIADIVYRRLVLCVVQPARQSTGMLWPQLYAYMIVSLVLSQCTLIGVLLLKQAPSLPLVDPQTLSKRVGVFTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WQ23</accession>
    <name>A0A6G0WQ23_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Expansin-like EG45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_012963</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000164">
        <property type="protein sequence ID" value="KAF0729465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WQ23"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010022"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010023"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22271">
        <property type="entry name" value="DPBB_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.760">
        <property type="entry name" value="Expansin, cellulose-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007112">
        <property type="entry name" value="Expansin/allergen_DPBB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036749">
        <property type="entry name" value="Expansin_CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF21">
        <property type="entry name" value="EXPANSIN-LIKE PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50842">
        <property type="entry name" value="EXPANSIN_EG45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026226292" description="Expansin-like EG45 domain-containing protein" evidence="4">
        <location>
            <begin position="18"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="505"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Expansin-like EG45" evidence="5">
        <location>
            <begin position="22"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="218"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="225"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="259"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="367"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="465"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0729465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="563" mass="57154" checksum="D5BAB0864D101DB4" modified="2020-08-12" version="1">MLQNVLLLAAVATQVLAGTYSGDGTTYGDGDPANGNCALMKYASFAPAFHVALNNDQYNSGANCGRCVSVSCTDSRCTKTAPVIAQIVDRCPECKHGDLDMSLQLYNAVTGYTPGRVQITWDFIDCDIDGGIQVCAKSGSSIDWLYVQPGNARTGVQSMKINGAEAPIFAHSYYFMSTNLHVVPLSQTVVEMTAYTGETIKATVSLAADQCTQISHQFRAGGQSPPSPPSPPTQAPPPPPTQAPPPPPTQAPPPPPTEAPTQAPTQAPTQAPTQAPTLAPTQAPTQAPTQAPTQAPTQAPTQAPTQAPTQAPTQAPTQPPTQAPTQAPTQAPTQPPTQAPTQAPTQAPTQAPTQAPTQASSKAPSQSPTVVPTDAPTAAPTAAPTAAPSSNPTSAPSEQPTAAPTSAPSQSATSAPVEPTEAPATVAPGSSSTESPASDPSTPATTGQDAVVTQSPPGPNPATSPAPSSSSSPALRPGSSPSSAATPTANDISVKSAGASSGSSTYLIVTMCFIAVGVAAYVVVVRRARRGIVDTPKEPMVVDDSRALSELPILETPTRRAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WQ96</accession>
    <name>A0A6G0WQ96_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">A-kinase anchor protein 7-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_012816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000163">
        <property type="protein sequence ID" value="KAF0729548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WQ96"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013291"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034237">
        <property type="term" value="F:protein kinase A regulatory subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010738">
        <property type="term" value="P:regulation of protein kinase A signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019510">
        <property type="entry name" value="AKAP7-like_phosphoesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052641">
        <property type="entry name" value="AKAP7_isoform_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15934:SF2">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 7-LIKE PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15934">
        <property type="entry name" value="RNA 2',3'-CYCLIC PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10469">
        <property type="entry name" value="AKAP7_NLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="LigT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A-kinase anchor protein 7-like phosphoesterase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0729548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="181" mass="19835" checksum="D701CEC690B5D93A" modified="2020-08-12" version="1">MQACARLQETLVTRDPRLLSALIPLEKLHTTLCMVNVSSATEIATVHRVVAENQHLVNEYMTTEDHSIALNGVSTFGNRVLYAQVDSTAIRSVATMLQQRLRENGVNLVGNHEPFQAHVTLCKLSGRNHSIDASIDGDLMADCPLGSLRINTIDFCAVGSKHLDPSTPRSFSRLQSSGRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WQR2</accession>
    <name>A0A6G0WQR2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_012651</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000161">
        <property type="protein sequence ID" value="KAF0729760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WQR2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010865"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0729760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="593" mass="63324" checksum="DACD3CD1A055E21E" modified="2020-08-12" version="1">MSLSSECNTFSDCADAPCLLNSITGFDVGNICWSSACRQDMDTAAAALPSCDEAKSPLAVINGIRAVCASNKFGSTLPLCSEDINYRRIPLGPKCQALAPSNSTMLRDFLKYSLSNNSQAYCASTGAAKDCMDELLTSTIPKMPACQDLYTYWNIGDYLSVFLTAFCAESPATPSASLTNCVAQLSPFLMYPISTTCSSIFGSYSNYYKFISDLMVDNGPKAFAQLCSQTSCVLDINDAVALLPTNACRSIVASDVKVIQAYCAYNMTATATQPNCSSQLSTLEDTILKFTPDPSCTSPSSSLKYVLAPSTVRYFDKYCSQKACVDASIAMAAQMPNCQKNGLSQPALYGGVFSSICKLCWGQDATKLQNALAMKLSPECKAFSSFDDVAGLIRGFNEFAWGNICWSSACRRDLDTAAAAFPSCEDAKSPLAVVNGIRAVCASTKFGSTLPLCDKKVDYKSVSIGPICQTLAPSSTTKLLDFIRDPILNNSQTYCASTGAAKACMNDLLSSTIPNMPACQDATTFWNIGDYLSTLLTGFCAGPPATPTASLTNCVAQLEPFLTYPLSTACMSNSRIFNLFANKGPKEFAQICS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WQV9</accession>
    <name>A0A6G0WQV9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_012689</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000161">
        <property type="protein sequence ID" value="KAF0729801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WQV9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004734"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="3">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0729801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="40234" checksum="314501F913815E75" modified="2020-08-12" version="1">MINPHFSLSRVKSFVPNFEKYTTERFLPQLAKAAKSNESFDLNHALEKLTLGIIGAAAFSYDFHENPAVYDAFKLMFAPPSVATYLGLLYIPGYAYLPFPEVRRRRTGRIPLVKALMEVIETKLASKNSPKDLLDLILPNTTPEEALAHTMSFMTAGHENSSSTLGWVVVEISRRPDVVAKMRAECNKVLNKHGSIDSWNAKKELIYTNAVIQETLRLNTVVFTLLRRVALADDSIPMSDGSSIFIPKGTNIEIVSAALHRNPRYWVKPDDFNPERFIPDTPEWIADEKKRGGSSHNFHYLPFSFGSKGCIGQRFATTEMIVILALMITKFDLQVDTTRNLRPLFNGLSISPVELLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WSW7</accession>
    <name>A0A6G0WSW7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_011955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000153">
        <property type="protein sequence ID" value="KAF0730532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WSW7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015898"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0730532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="159" mass="18240" checksum="3A1271159241697F" modified="2020-08-12" version="1">MPQIACLPWHKPAPMSSLWRTFALCSPQATRPKRKQVTFTTATTYIFPLEYGGSAIPSDHGPPIGLANAHTRQECHHLDNVGPKRGRVRKFDHVERMVLLQQKASYSRKEVASFCFEAIAIRQSRLDTQYDDEEEDNDDEEPQHVVKRRKIEHSCKSNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WTG3</accession>
    <name>A0A6G0WTG3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_011835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000151">
        <property type="protein sequence ID" value="KAF0730723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WTG3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000871"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026156940" evidence="1">
        <location>
            <begin position="21"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0730723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="214" mass="24125" checksum="D390EA07C478B372" modified="2020-08-12" version="1">MGLPLSLLVGALLFLATCLAVCVHRIVQQVKHARRQQLVAFFATNKFSRSYVALSTPPSMIFENHPPATVTQTVPEKLPPLDQFQAVRARVVPWWRPLLDWYRREKRAIIPMAFDLVDDDTLGHFALFLAAVCHAGLPHRLAELQSLCCLLDVVKWRYIVKLDALNIEIYPSMSRRALAKAIFELLNDEKRFASIARGEDVLVAVLSATPRSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WTR5</accession>
    <name>A0A6G0WTR5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_011753</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000149">
        <property type="protein sequence ID" value="KAF0730869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WTR5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012842"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902495">
        <property type="term" value="C:transmembrane transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052076">
        <property type="entry name" value="TRP_cation_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47143:SF1">
        <property type="entry name" value="ION_TRANS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47143">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL PROTEIN PAINLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="390"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="481"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="510"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="563"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="594"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="625"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="702"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="37"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="72"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="105"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="171"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="204"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="922"/>
            <end position="982"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0730869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="988" mass="111492" checksum="BDB9EF5D31975696" modified="2020-08-12" version="1">MPAVDKALAELAWNEDWPEIRLRVESNHTPDLHELFFGMTVLHWACYYGNSDVVALLVQQTNIDINAPDTESGQTPLHWAVFKGSLPCIEALLDAGAIVHSRTKDGRTPLDLARTTPHTAIVQRLIQAGGDPGPSGRRLPARLSFIQRGDVVKVHEWLSMAPTSVDARAEEDRTPLMLAAGGGHFTIVELILKRSPDLDAQDSMGRTALMYAALAGHPLIVELLLGQFADIDLLDNEGLTVLGILDQTIKNMMNGPEKEKLERCASIIQKEAKYRDTSSIYRSKVRDQVLERLREGFDESVFKMAIQCDPALGRWMLNDCLIPSRHALAFHELEKVYGHKGIRKSALYTILKVSDNSFVTKKLCLNHIVIRRILQIKWELFGKRMYIEKILMYLLLLTCITVSATTSKNDLVKPTAMNSVFLFSILNFAIVCIFLVFGWLAAQMLRPKPLWCFTRYLVDGKVTSFDAGVSVTASNRSRAQWYILIGAIVLSILACIPAVWFLYIYATNEWYPRFNTVNIVLLACTTVYFLYLEIKGMANDYIAGFNPSKGGYSLRGSLYFRSVLNWCQVTVYLVILIFYVPWELGAFPVDPSHVATVHICLGTFLSLSLWAMSLQFLQVHPSAGYLLPMLSGLLGDVWNFILLYGVLQWGLSCAYMHIIKPPENGEAGYETWFRAFTFAYFVLVGEVDVEEKFGQSNHVVYAYGRFIVMVQVAISSVLLLNMLVATMNKRVLDGLQVAKIEALASYARFVLRLEGTLSPSEQSEIKYMADATGHASLHPTFYEPIVKPSEFSSPSDIEVVEGIQAQRQEWIYALEELQSMVLAEYKVLFAIYSQHEMDLQSSEQLVAAQFNFAMTKPHVNFLCVDETLTQLAAWIELHLKTLPVDEAHMYNMHTHVLPRFHQIGQVLAANARARVAPQPKSSTTIEETKQEMLAQIQAAEARGRQNALATQEYILQEMQRQNSQMQMKLLEMETRLSQLVQQQLTTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WUB2</accession>
    <name>A0A6G0WUB2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">THH1/TOM1/TOM3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_011601</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plant tobamovirus multiplication TOM1 protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000147">
        <property type="protein sequence ID" value="KAF0731053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WUB2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004591"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040226">
        <property type="entry name" value="THH1/TOM1/TOM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009457">
        <property type="entry name" value="THH1/TOM1/TOM3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31142:SF3">
        <property type="entry name" value="THH1_TOM1_TOM3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31142">
        <property type="entry name" value="TOBAMOVIRUS MULTIPLICATION PROTEIN 1-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06454">
        <property type="entry name" value="THH1_TOM1-3_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="THH1/TOM1/TOM3" evidence="8">
        <location>
            <begin position="23"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0731053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="331" mass="37845" checksum="A0E85510BB486C7D" modified="2020-08-12" version="1">MTMADFEAVLLLANGTEGDANRRAFIATGSIYAVLFVVCIVQLVRNCRSYAQWIQQKWMHFLLVLLTLTRAGFLLSVGMFNWCDVTSEGVLSPACEANGLERQLFYILDQLPNMFFFSMYLVMGLFWAEIYYNATDQLDIFLHVIKPVSKLVHVMAYFLQIGLWILYADPWRSEDHYFGRGYAAFSTSIFLLVTTAFVVYGRLAYVELRAVPVDLPIRTRKLKEVTVMTTICTTCFTARSLLILHLSQDHVQLADHLTWLMILLYYSLFELLPTVVILHFHRRFPRPQASPTLAKAAPYRFIATIDSDSDSEAPLSPEDSLRQTLIHPSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WUF6</accession>
    <name>A0A6G0WUF6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leo1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_011434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000146">
        <property type="protein sequence ID" value="KAF0731168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WUF6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019792"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990269">
        <property type="term" value="F:RNA polymerase II C-terminal domain phosphoserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007149">
        <property type="entry name" value="Leo1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23146">
        <property type="entry name" value="LEO1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23146:SF0">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN LEO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04004">
        <property type="entry name" value="Leo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0731168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="415" mass="47522" checksum="FD4A1DCD1B5414D3" modified="2020-08-12" version="1">MSSSEEEVELPKSSTSKPGEKDNSALFSDDSEISDAEAPAKQPKKEKAKDDGSDNGEEMADLFGSDYDSEEEFKASGIKEDPVREDSRGSPMDNDEPTTSSYTRVHEVDDAHHDELQIPKGPKAPRGSELFFTRPPNVLRFVPDAFTSESIKKEKEETGDEGIYRNYVRWRYKLDGNGRIMVDPKSGLPVRESNSRIVKWDDGSYTMFVGGEALTLTQQRVANSFVFVNEQSTDETVLECHGRVQSKLTIRPISTQSSSHQSLKMSMRARHNKAVVKIQEYISEVDGTLDKEQKAAIKQEQMRLENRKKQRQGYEYDRDRSSRLDSNFLEEGYDGVEYDDNNLSAIKQQYGHKPKKTQEKARHRTPVLRPGGLDEYRQQKEQRHVVDDDEDEEEEEDEMITRTNKKRRTVDEDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WV64</accession>
    <name>A0A6G0WV64_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_011418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000144">
        <property type="protein sequence ID" value="KAF0731355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WV64"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021330"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0731355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="400" mass="44887" checksum="FB124D5E161FF036" modified="2020-08-12" version="1">MISLLQHQEGTPLSDLEAIQLFKDAMPLDMQLEFRRKHGAVFFEVLVDVEAAFLAIQEDMRWIKARTQTQSKNAGTHSSDESKPKSKKPSSKPQQTKSTPQKPKGKPKCSFCDSKGYKADNHTSEECGRRDNPKNTEEEKPASKIKHVKFTKKTKEDLAAMVNEIDDLTGSSYESSDDGAAMQEHAEAVAVENGCNTWSESNGKKMVLKIRVALLIGTEQQVVSGLLDTGSTTSTVDASYVPKQLCDLFLRSRFRKIDATIGETLGLAHIPFKLIDFSTTRVLTQPLKILDFLIDQGMVFDFDKRIIVWDEIQMNMAAQDLAATSITTKQVILDANYDMPKLEAMVPDHLHPEEQLQLLQLIRRYHGVFEGRIGNIHNGTLRDPLERKRRPVCSTPLSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WVJ0</accession>
    <name>A0A6G0WVJ0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_011128</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000141">
        <property type="protein sequence ID" value="KAF0731502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WVJ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001713"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF275">
        <property type="entry name" value="LD06095P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="12"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="780"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="789"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0731502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="948" mass="105384" checksum="F981F93CF6B4A3E8" modified="2020-08-12" version="1">MLRITSLLSAIGCVYILARFFRRTSRSKDISFVLVTALAGFELVIAIAKFPALSFLNFDKVEGGYKLVQEGVGTMCYVQAFLLDVFMFQALLWNACMAYNLLRWVVYRDGDDKLRARFWVYFFASSLFSVLWGLSAALPIWPSSINKGGRVNLFGYAKFTCWMQGSKYFMYRYFPFLVLTLVFIVAVMIKIHRVIRSRAKLGVSMLPSTSNDLVTKIQHRLVLYTMGFIVLYTPITVYRMIAAVSVETAANLTALAVISQALLNLQGFFNAVIYGGFLQSSRNRSDSTLSDNLPPPSVVLEETRSGISSTVRGVVGNDVSIFASTFNMAEGAVSSEDEFEKWIPRGHDVYVIGLQECLNLQPMRQAMVSHLKKINGKVFVEYGREIGRKETKLGYHGFIAITVYVASEEVQAGHFQMHLEAISKVNRGTNLIGLGRASNKGAVGFSFSYYNTTFAVVNCHLASDTSGKSKIKKRHRDGINILTSMHLQSIDNEFDCHLMAHHTIFMGDLNYRLTAKCASPKTVVQMIASILNTTREQSAMKRGQIYSYNQILAKDALKSEADTYNVDAEDVYVIANTPSALTKPNDCADEHATTPLRRSELMESSFSNTSSVEVTWKTLMDHDELRRSMEDGVIFHDFDEARISFPPTYRRVLGKMLDTSAVNQWTPALVSELYTTVLGDSKVRVPSYTDRILFHSLPGLRGQMNCVQYTSAEFIGTSDHKPVSCVFEASVDKKTSSLMYMASARESPQSKAKTLDHFTVYLSKLSVQWGAALESFSIGEDDESDENVSKPSNASLSTESRSSIPSGMTIEGMQVRSVFPLPCEDVFAEERKLTEVADQLLLNATHGGDAKYRLKPTWKVSPWSVLSNQGLKQSAALQSRKLMHVALNFMLPWGASAGQCVIDLAEAKRRFGSHFDFSVALTIGGRRTGTLSGSVCMAVDKVNATLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WVM4</accession>
    <name>A0A6G0WVM4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_011153</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000141">
        <property type="protein sequence ID" value="KAF0731528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WVM4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014041"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF298">
        <property type="entry name" value="MIXED LINEAGE KINASE DOMAIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="4">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="210"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="130"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="176"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0731528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="512" mass="57108" checksum="29B7520144EFA0D9" modified="2020-08-12" version="1">MELHMHVFEAKGLINKGSFLGKQSPYCTIKVAGQKFKTNVNIHGGCNPVFNQEFTIENVQRDHDFQIEVKGHRTNLPKTHLGVYGAKVELALNESLGQSKWYTLKNINKPNTDAGQLLMRMEYRSMAAARNTTTREGALASLPVRTTSVPTSNRGVQPSDKGFNHFNSAPRPLRPSSDSVGSSNGSARSGTSTGPRVRPTSRITLTRPPVRPSEVSANGASSPRSDEIDWTDYEELRPYRHFYIYPSTVTIIRQVNTDYMKTQLGHFGGEHVMVKSLKVPSERQTLIKEVIALSKVDCPKILAFVGFYIDPAAGGLHCITYHALANPPTLRELLNRMGPRLKFSEKLQFAIDVAEALEYMHAQLMMHRGIRAENVMLTKRRQAVLSGFGTCRDKSYDQTLTVGVGDIQWSAPEMLLDGEYAEKVDVYSFGVLLVEIETGKIPFEEVSKRMTRTELSNAIVTGKLRPSPSAGCPPPYKRVIDLCIQFDSQLRPTMSEVLDLLLEIQQNVPLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WW77</accession>
    <name>A0A6G0WW77_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA pseudouridine(55) synthase</fullName>
            <ecNumber evidence="2">5.4.99.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_011080</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="2"/>
    <dbReference type="EMBL" id="VJMJ01000140">
        <property type="protein sequence ID" value="KAF0731778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WW77"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003065"/>
    <dbReference type="OrthoDB" id="9995526at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160148">
        <property type="term" value="F:tRNA pseudouridine(55) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02573">
        <property type="entry name" value="PseudoU_synth_EcTruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01080">
        <property type="entry name" value="TruB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014780">
        <property type="entry name" value="tRNA_psdUridine_synth_TruB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00431">
        <property type="entry name" value="TruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767:SF2">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE TRUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767">
        <property type="entry name" value="TRNA-PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase II N-terminal" evidence="5">
        <location>
            <begin position="23"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0731778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="316" mass="35085" checksum="1962D96A5B024443" modified="2020-08-12" version="1">MNGFINLTKPPGLTSHDCVARVRRMLKTKKVGHAGTLDPMATGVLPIAINRATKFIQFLDKSKAYDGTIRFGITTDSDDITGTILHQHAVPWLTQERIESELNKLVGHITQRPPVISALKKDGSRLYALAREGMATLEDVPLRKVTIHSIDIERFDPGEFPEMTIRVACSEGTYIRSIARECGERIPMPHELQAEAPTVGATLSMLHRRQSGSFHSTTSYTLEDIQDGNFTLSSIESALTHLPKWFVNSDTEARWLLGKPVSCVDSSSFMTPQVVVAVYRREEPSKFLGVTTLVRSEDDSDKSYIVTGSRIFATPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WW90</accession>
    <name>A0A6G0WW90_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_011111</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000140">
        <property type="protein sequence ID" value="KAF0731813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WW90"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011381"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052578">
        <property type="entry name" value="PI_Transfer_CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824:SF29">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="244"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0731813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="421" mass="47414" checksum="B01D14F621AC39F7" modified="2020-08-12" version="1">MASGDVRYQGMLWLACSFLVILFLDSIQEVTLLQKIVLVVWCFLGKVYLHDLHAVAVTPAKSPYPLHSPRRRANTQRPTVQTKPTVNTNTQIGAPNLPTMNKSQSLGNLLQPVSTPTLKRSQTTTTLLVGSVNPQEPSPLHAEPASPRTDSEEDDLSPTSGGFSITEDDNTRLENFKRMVNLSELDGLTYTDDYLLSVLNVPGRAVQYAADKLNRIIQWRKEYNASSLSVEEVGSQFKTCSMYWYGYDNFNRPILWLRPKKKDWAHMNNDLEVRANVFILELAINNFMPPGISCFTLVLDCKDVGYRETDISLTKSLCQVTTGNYPDRIGCVAIGPLTMLVKALTRILSPLLPPRLREKARFMDNPFESLAGVMPVDLIPTYMGGTNPHDLNPDQEEGRFEFEYMCAEMRRRMTELPTLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WWD1</accession>
    <name>A0A6G0WWD1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_011100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000140">
        <property type="protein sequence ID" value="KAF0731799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WWD1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001025"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="681"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="961"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="681"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="694"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="725"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="791"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="841"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="855"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="886"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="914"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="995"/>
            <end position="1008"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0731799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1019" mass="113440" checksum="72E157E9FABFFF15" modified="2020-08-12" version="1">MEHEANWVLEGDGLVENLFYYLWCKDEFGGGPSLLIPDTVVYKFTQPAYWYFTSKSGKVKKKSKTSLTNVMIEKEFCRKACGVDIVAYYIYMLNDVPTIEYFTVDGLKDFLYSRQKIHNGILQRFIVPKGSANSMIRAIWTPKMCLLERKTNIRRLHDLRYGLYERAVTFDGADAYSNPDPVRGSVLPGDIQYLCEQVVDHVMEVSFHKYRISRMVLHIKTDAEDKVWLLWSSSIRLAHPSRSHNSNAMNSASLGHHKPVDITSDAQVPAFVHLNCMPDSKPKANQPKVFAKCHSCAKSIDSSTTSAVPYKAILEHFRHLLHHMKQDTKPGAAVLWPPDPAIIRAAGNVGFGILNELDDDEGGGPRKPITEIDVMVPPVLRYLHPNLSLADFKRFVHDPVFLYKTTTVCDDCFLVYADYATSALDVNTLRQEAPAILRPLREIPPLKQINRVKHPDAAWMPTGSVPKSTRPPMTNMTKSQYSFKQPPTMPSRIDHTVFDDVARQLPVELRYSSSTPTLSIQEEVTASATLGRFLPDAWKQPPSMAPNPLVSNNVKATKENSFFSELSASSMTLETHHPLRHMVESASQLASSTSMPQLKTEKKARNPYTVVQTLLDDEKPKKVKLRPKKKLAFQKLAHTSEEEQVTSMQHREFLLNALHEVQRQLDNPDTLEDVLREDAPNANKSFKDARKAQVTVSNPPTKQATPPVLNETTTEALISARRKSISRESMDKGMSPREESVLDQLDDLSTPRSERQATANDALRRGTPRLAANDPSALQDTNEEGHPSIGSARTITPRNAQMQDTTSPRSSRNGMDSNRAEGPPTPRGENTPEEYATSPRTSEHSPRPDSRPTEGNKSSRPHTSSDGKPASPVVTPRGILSAPPHRTQSTTDHSSPRESTTSDNDAALPVRSASKPNSARSANDEANTNLFNDKDVAVDAMVPSPRGNSTVQEAAAILAMTELPSDDSNDVYHLSDDEDDRTQLDISQELTPDVPPRRDLNVSRESSSHDAAATDGLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WXA0</accession>
    <name>A0A6G0WXA0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_010812</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000137">
        <property type="protein sequence ID" value="KAF0732162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WXA0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006108"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032854">
        <property type="entry name" value="ALKBH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010666">
        <property type="entry name" value="Znf_GRF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212:SF4">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06839">
        <property type="entry name" value="Zn_ribbon_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51999">
        <property type="entry name" value="ZF_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CUE" evidence="6">
        <location>
            <begin position="4"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="7">
        <location>
            <begin position="231"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="GRF-type" evidence="8">
        <location>
            <begin position="350"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="402"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="403"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0732162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="432" mass="48912" checksum="F785A5B2B7E7D9E3" modified="2020-08-12" version="1">MSATFERTVAALEEMFPQASQSKIRTTVAAVNGQLDAAVEILLDPNAKRKRKLKPDIRSYFGCPSRPPQDTKKLHIDSTIPSEFLHPNKQLQIATFESWNAAKEPQRPILLTPETLTPNVPCLTIQMDFLPADQANAALREMLETSGDWIRTKWVIFEREVESPHHTQLYGATETQLRQKEDLYTNTGTAATKMKLFTPTLHAIKMPIDDVVNRALSTRERHPLEAPGPWHANLALGNLYKTPEQSVGPHSDTMTELGPRPTIASYTLGAERIFRIKRLATDTTPAQTFNLKLPHNSLLIMFPPFQEFYRHEVPAQQPWQIKAHEIAREARVNLTFRMTRPNYMAHIPRCQCNKPAVLRTANRPNKKNVGEYFYICAGSVPASCTYFCWLKDRMHLLEQTANEPKKEAQASPTEHKGDAPSTQASHVVDKHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WY33</accession>
    <name>A0A6G0WY33_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_010472</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000132">
        <property type="protein sequence ID" value="KAF0732483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WY33"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016376"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000163">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="299"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="688"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="727"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="809"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="939"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="88"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="404"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="691"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1000"/>
            <end position="1234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0732483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1239" mass="136832" checksum="60C7BB16FDB1F11E" modified="2020-08-12" version="1">MYSTFEASPPRLKQQHSYIESATFISKLTFGWATPLVALTKKRLLATDDLSYPWHVDDKIKAAFTLAFEKHASLWKAFATTHGIQFSLFAFAQVVIVACRLYGPAYVLGQLMQSVNAPAFDMVHVFWLVLSLYALLVVKAFLETHVDFAADMLGAQFDALLHSMILEKSLHRRTKTSHIERYLDKNAASSVAAFPRSVMGLWGSFLQLGVIVWFYFQLVGSSIFVGLAAIVALVVLRTYVAMVAANVRAKTTSLSVQRLASISELFATIQTIKMAALEEKFLTAVHRLRDIEVDSMWQFSCYITAWTVLMQCTPIVGLLVVILTGTTWLDETLSVVTIFTALALLDILRASIIDGATAIKLTFEALGCIHALERVLVVEKAASSLAQPDALPISNEPKNSHVAISIQNATFGWTADQPLFQDLELEIYRGEFVVLYGSDGQGKSSLCSFLLNETLKTRGTVHVAGRVAYVAQAPWIQQASIRDNILFGQPYDRLKYQRVLDACGLTQEIALFPSGDRAEVGSNGVSLTPDQITRLSLARAGYSDADIYILDSPLASIDPSKVDAIFKSYFLGLLKQKTIVLVSNDDKIVTSEDVNRTFLVQDGTLVETTYDTLTDVASTALTSTAERRTSSSASSTTPSSTTSSFFEALGFTPRALDGFNDEAVEAYTGRWSAFSATFAYGKAFGGRTVIVIVLFASAAVQGAKLYTDIWLSEWDAEAETPQSLASYSWIIFWRCFFLALHSVLVFSYGSSASQFLFRTALETLVRAPMRYFDATPVDHILARFRDDIAACDLILPAAFARLLLETSSLGLSVVVLFVFSGWLSWAIGIPLLVLYIRFVPSLFVAPTLTRMQSTTQTALSQLTREATQGSVTIRAFGSPSINHIRHSHRSLLDRSCSAKVISSGVNQFVQLRVQLMGHTMVFVFLLASMSQHESIGAGLMGLLISYALTIPTLLATLPMVWSRFNSQLHSSDRLLELTHVENEGGRGFSTYESWPTEGRIWFQNVSFRYTRHEPLALRNITFNIRGAEKIALVGARGAGKSTVAMAQFRINELASGSIKIDGINIATLGLKALRSNLAFVPQVPVLFRGTVRHYLDPLDEYKDDAIWTTLRKLQVDSLVGRMEHKLLELVEDVEGAFNASERLKLCLAGALLREAKIVVLDEITTGLDDQADQFLLRIVRDEFASSTVLTIAHRLDTVLDCDRIIVLDRGELVQIETPQVLLAQRSGVFFDLVTREASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WYI0</accession>
    <name>A0A6G0WYI0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_010321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000130">
        <property type="protein sequence ID" value="KAF0732613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WYI0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020468"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0732613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="462" mass="50906" checksum="C17FDA7F1FEF1EC3" modified="2020-08-12" version="1">MSPKRTQPPPVDEANWNPYGSFGAPKSAPTAGTSSGGAAGGTMDEDVGIEDEDMDDCGMVLNAPALPQPPNFKGSTKAERRTFMREYQKYALQVDALRAAGQQPFLMPVSACIDHFTKRRVAVFDFEKDIQEITEEEWVKWFKEAYEETPVELDVLKKRLQAAIVFDLRITDADSRVSRMLDNLMKALEADGQEWVLHQEAKLVVGLITKVIQPVALQKAVTKQMELSRNKPLKADVVRFVKWLRQYATGYQLYGGMDNDKPAKPADEEMKRGTPRGGKARGKENASGAGEERAEGAKKPAGDAKKPAMTCLKCGSNDHLVRDHPGITETEAKKLIADWHQNRRKAVKAVKAVDKESEAVTSVKYGATVEGVLALPTVLLDSGSDESLATLGLVKALRNLGVEPEFLSKTACDLKPYGAESKPLRVYRQVRFKTLELNTSFGPLMLRGLTAWVDEGQLIVIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WYN4</accession>
    <name>A0A6G0WYN4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CBM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_010314</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000130">
        <property type="protein sequence ID" value="KAF0732606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WYN4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015131"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.40">
        <property type="entry name" value="1, 4-beta cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016288">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036434">
        <property type="entry name" value="Beta_cellobiohydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34876">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34876:SF4">
        <property type="entry name" value="1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01341">
        <property type="entry name" value="Glyco_hydro_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00733">
        <property type="entry name" value="GLHYDRLASE6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51989">
        <property type="entry name" value="Glycosyl hydrolases family 6, cellulases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026278780" description="CBM1 domain-containing protein" evidence="3">
        <location>
            <begin position="28"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="4">
        <location>
            <begin position="374"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="318"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="322"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="355"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0732606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="414" mass="42936" checksum="69724EE2BA9C338E" modified="2020-08-12" version="1">MKVSIVSSALSLAALAYSASSANLCNAVEPYSYVTAATQYPELKNAIQALSANPIATWYTDRGSNQVAQILSACGNSVPTIVVYGLPNKDCGEGGFSNGGDNTNTQQYTAWIQTLVSLVGNKEVIYILEPDAVGLTSTGGCGVTNGYQNNLKVALGLLSTNPNAHIYVDVASWATQSAAVSILADLKKAGRLQGIAINTSNYRATSELTALCNTYSSATGGLHCVFDTSRNFNGASSNEWCNARFGGVGVPPTSNTGNPLVDYYLWIKPPGESDGQCTGQSADAMIGPAAGTFFYDGFKTLWNQGYYVKQLGMAPIGSGGEPPVTSSPSTTVQPTSTPTPTTSRATPAPTTSRPPSTPSVQPTPTPTTSSPSGGVAQPWAQCGGSGYTGPTTCTQGYKCSYSNAWYSQCVPSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WZU7</accession>
    <name>A0A6G0WZU7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_009954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000126">
        <property type="protein sequence ID" value="KAF0733133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WZU7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021307"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0733133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="421" mass="47289" checksum="26CE3B7F3AF8DE0F" modified="2020-08-12" version="1">MMSQAEWNMLDQRCTRIDETLQLWTQRLESLEEKVDALPLQICRLLEERQRETSSAMAVHQALQKAMQVFAEAMTPAPIRVQPDRSPATAERTPIPPPPPLHRSFSANKASLASIMTSPAQDSLPPSSPRPLPPPVVLAEDAEEAPPPPPNEPTEPLTTFIKVEPIEYSQSVNSIIQSPHEHYATESTGMPASLPVEIPAVTQIRVESSARLGTNPTTSTDDEDDSVKSPRLESHHSFLRPPRPAPSPVRNTTPSRRPISLTPENLPVFTWSDGSERHAPEAWEFPSTNCKTMWRLWFHGDATHSIGPFRHLKSRDIERFAKDKTSRKQLSRARTVMNKLLEIALENSWIETVEELDGKSEDDLDAIFDQAFDVLLHHNPEGNLAGDGKLRADRATSYTYSSVHTFMVPMSRKRKHLTPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X0S6</accession>
    <name>A0A6G0X0S6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_009635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000122">
        <property type="protein sequence ID" value="KAF0733386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X0S6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009084"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09487">
        <property type="entry name" value="SAM_superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="1">
        <location>
            <begin position="191"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0733386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="266" mass="29858" checksum="4E717D369F23F641" modified="2020-08-12" version="1">MDEATWTSMPSNDGDDNNVWNRLPSREVIQETIMNSIPSRETVWNGINAVPGAVAATPACIAGAFGNCFSRVRRMQFDQDQKRSLLSNLYHDASRINIRDAEVENATLELRRRIQKAEYEKHRRMEVEAESKLSHKKEPISVDDTETNFVDSPDVTSAANVNAADIRKMSVDELLSLDGITPSETTTASSLEGGRLRKWLSDIDGNKSIEYLSYAASFEKHGFHSTDDLALLDEEEVDRALTEVGVHKFAHRARIRKAILRLSQVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X0X3</accession>
    <name>A0A6G0X0X3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_009697</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Folate-biopterin transporter (TC 2.A.71) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000122">
        <property type="protein sequence ID" value="KAF0733451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X0X3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012394"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039309">
        <property type="entry name" value="BT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585">
        <property type="entry name" value="FOLATE-BIOPTERIN TRANSPORTER 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585:SF5">
        <property type="entry name" value="RNA-BINDING S4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03092">
        <property type="entry name" value="BT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="476"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="519"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0733451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="571" mass="64335" checksum="8C39F7A09E9DCE7B" modified="2020-08-12" version="1">MQNAHSVRASFNSWASQELDPNEENGYHDSVNGAPLRPGGVRNLYSRQNIGLLFNYICTGWVEAILPATIYPFMTNYLYMDGYQTQAAIVLITLPYILKTVFAILSDCLPIMGRRRIPYLIIGWAICLCFLISCAMVRQGESYWQHGDLRTFQDQSSRTVINPDAPNEGWVYIILMMGATAGFCMADSTGDAVMIEFAQREPEHIRGTTQTVITLAKFVSGGVAAAIVAICFNGYDYGGTFNWSLNFNQVMIVAMLAPVVGLCTSTFIPDPPIIMSDDEEMSDELTFREIFNDLWNAARKRAVWQLMAFNFLNAFFFDAVAAPSDVIKRTWARVPPIVDGVFNNIFAVFLFALAMHLTRNHFLHSDWRLVIFITTIITVAIQWTVDFLMVFDVVRSPEFYVGVPLTYQVPVAIRNVVVTFATVEIADERFEASTYALISTMNLIAGPISTSIFKQIDASFLAYKEDIAKDTHEVRWQVAYCLMICYCARLFSNVTLLLLPRQKKEAQELKLKGDTNPKLASATFIVGFFALLWGIVTNLMSIFPATSCFPIAVVENILICYETYTRFLSPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X0Y9</accession>
    <name>A0A6G0X0Y9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_009715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000122">
        <property type="protein sequence ID" value="KAF0733473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X0Y9"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0733473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="405" mass="46703" checksum="A1A39AA17CDBB28F" modified="2020-08-12" version="1">MALTDDDKLGRHAEEHATDHEICVADLLWLAHTALEPSSILRHVPRRPSGENSWTKNGKTAAVLAVSWLFSVREQPRFARERCKSRALRCRPHGACQDLESPKMTEDKMRRILDSRNEHDSSEWDDGKNASEQEHFVLGGLEDARFLMRIVQNWLERGVDLLVLAAGFPCLVRLLGSPLGKHHVVVVIRHIAPRLARDETRLALRHGLHLFHETRDRWLETAAHHSLRQDTHRTRHVEMENGSFRGRRRHAARLCRILARCVPCRYKVAVKSHPQPVKFLTAVHSLDSVSSMMHNLVALSPRVIQCGFDRESSQRWLHSLAQPMGRPMVYCVKKFRDMVDAAFFLADLEHFDGCINGRKQSHGTVTIQPMKRIVRKSIKDDKEARRRFYVMRQNRITKTTVKSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X120</accession>
    <name>A0A6G0X120_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_009779</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000122">
        <property type="protein sequence ID" value="KAF0733545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X120"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017231"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="170"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="1">
        <location>
            <begin position="482"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0733545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="556" mass="63055" checksum="DDD9B5CA765F51D7" modified="2020-08-12" version="1">MVMATFPYTLEHVAGEVNVWGDLLSRWGAAQQRRPVLRVRQLAVVVSPLQKLDFEWPMADKIAMIQRDALRDKTTDGMDVLWDEEAGMFKLHDGKIWVPDAAVDLQQRLCVVAHQGAAGHRGIDVTTKGVMDLFTWKSAKEDIEAFVKGCIHCLCVDGVVVPRPWGSALHAEKPNELIHFDWLQLPEAKNGWKYVLVVKDDMSGFCRLYPSSTADAEKTAEALMDWFTTYGNVTTWVSDGGSHFKNEVVAKIQKLIGAHHHITTPHSPWANGTVEVVNRLILRCMKTLLSEMRLRIDEWFRVLPLVQGALNHQPADRLGGIAPITAFTGLPAKPPLTGLVHPKTKKVHSIDWMDDKRKKYVAELCHALDVLHREVAETSEKRRKQARDAREQKRNVKVAKFAPGDFVLVGKIVQYPNKLALNWRGPFRVARMLADYLMEVEQLVEPFATSVHHACRLKLYCEGGLDVTEDLVEYIAFGDEGFYVEDILKVRREPDGSFMALVKWMGLAEEEASWEPALQLMEDIPVIMKRWMRSHRDEDLVAEMRRILEPKLGGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X1D2</accession>
    <name>A0A6G0X1D2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Enoyl-CoA delta isomerase 1, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">3,2-trans-enoyl-CoA isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">Ae201684_009522</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Key enzyme of fatty acid beta-oxidation. Able to isomerize both 3-cis (3Z) and 3-trans (3E) double bonds into the 2-trans (2E) form in a range of enoyl-CoA species, with a preference for (3Z)-enoyl-CoAs over (3E)-enoyl-CoAs. The catalytic efficiency of this enzyme is not affected by the fatty acyl chain length.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(2E)-tetradecenoyl-CoA = (3Z)-tetradecenoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:29847"/>
            <dbReference type="ChEBI" id="CHEBI:61405"/>
            <dbReference type="ChEBI" id="CHEBI:61968"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:29849"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(3Z)-decenoyl-CoA = (2E)-decenoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:77195"/>
            <dbReference type="ChEBI" id="CHEBI:61406"/>
            <dbReference type="ChEBI" id="CHEBI:195601"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:77196"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(3Z)-dodecenoyl-CoA = (2E)-dodecenoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:23716"/>
            <dbReference type="ChEBI" id="CHEBI:57330"/>
            <dbReference type="ChEBI" id="CHEBI:58543"/>
            <dbReference type="EC" id="5.3.3.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:23717"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(3Z)-octenoyl-CoA = (2E)-octenoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:46044"/>
            <dbReference type="ChEBI" id="CHEBI:62242"/>
            <dbReference type="ChEBI" id="CHEBI:85640"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:46045"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000121">
        <property type="protein sequence ID" value="KAF0733587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X1D2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003103"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000034">
        <property type="entry name" value="Enoyl-CoA delta isomerase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF45">
        <property type="entry name" value="ENOYL-COA DELTA ISOMERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00056147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00083575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF0733587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="293" mass="32659" checksum="3C874C7316CB3512" modified="2020-08-12" version="1">MLRNLRSFQALKRCKSTSAAPRVQVKDEKATPIVAVDSSLVTVERREGYAVVRMNRAPVNSLNLEMFKALEKTVADLEKDKAIKGLILASTNPKVFSAGLDIMEMYQPKTHRLREFWAAFQEFYLRFYTTPLATVAAIEGHAPAGGCFLAMCCDARVMATGKPVIGLNETKLGIVAPFWMKDVMQNTIGHRETEKMLGLGLQVDALTAKKIGLVDEAVEVEQVFPLAEKMLQEWLAIPGHARKATKHLMRNETAERLRRDLKGDTDHFVDFAETDRVQNALGAYIAALKKPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X1M9</accession>
    <name>A0A6G0X1M9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_009358</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000119">
        <property type="protein sequence ID" value="KAF0733790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X1M9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000557"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0733790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="17945" checksum="1EAF1786DB8ACA7E" modified="2020-08-12" version="1">MESKRPLMSLSSIPQSIIQHIAFYIPVAKDFLSFLVSFPDATSIGNLHYFFELSNILKPNDLWPKLQLQELTPSLVPRVRRITRFFTTIYVFEVFDLKLLQQCLHPHNVVELLTCPFWYDLDEWLTTPVSMLPVQHITIRRMSTGLDLKINLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X1R8</accession>
    <name>A0A6G0X1R8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_009394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000119">
        <property type="protein sequence ID" value="KAF0733830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X1R8"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56954">
        <property type="entry name" value="Outer membrane efflux proteins (OEP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0733830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="164" mass="17236" checksum="DCE5677BA9558999" modified="2020-08-12" version="1">MSTPYPTYPLAPSTQQAQLEAQQAQLRQQQEQLAQQQQQSQQAAIQHQLAMNQQLIQQQQQQLEQQRAQLAQQQANLNASRTPYAQPVYAAPPPVVMAPPPAVVIGAPPPVYVGGGPYMYGQPYGYGGGVAVGAAAGLGVGLAGGVILGSALGDGFCYDGGFFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X242</accession>
    <name>A0A6G0X242_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Myosin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_009154</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000118">
        <property type="protein sequence ID" value="KAF0733977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X242"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018001"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00124">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF706">
        <property type="entry name" value="DILUTE CLASS UNCONVENTIONAL MYOSIN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0518">Myosin</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="10">
        <location>
            <begin position="84"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="9">
        <location>
            <begin position="979"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="6">
        <location>
            <begin position="635"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1099"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="900"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1108"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1118"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="177"/>
            <end position="184"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0733977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1144" mass="129161" checksum="FFAE6AFD0ED71F27" modified="2020-08-12" version="1">MQRERATSAASTLVWVPHEKEVWKKAQMVQKLSEFEVEVRLVSDSDDYDPEEGVVKVYDVREIAKLAGEVSATAMPICNTFNKHGVADMCTLNHLHEPAVLKNLQLRHALCMPYTYTGQICIAVNPYMWLDLYRQDLYEKYLELPRADLPPHPFALSSSAYIDMQEHGIEQSILVSGESGAGKTETVKIMMNHLASVSGGGDSGSLVIEQVLKSNPLLEAFGNAKTKRNDNSSRFGKFAQLQFNNEGLLVGARCETYLLEKSRVVGQTMGERNYHIFYQVFSLPHEVKKTLLLDGSVGDYCYVRVGEGSKVDNVDDSEYLQETKDAMDTIGIDYREQQGIFEVVSSILNLGQVEFKAESSEKSSVLSVDRLESISKLLQVDSTVLASILTNRTMAARGETFTIPLNADQAADLRDAFAKGIYSQLFDWLVTRVNNAICSTRSVKHHIGLLDIFGFESFDHNGFEQLCINYANEKLQQKFNSDIFKTVQTEYIQEGIPLELVSFEDNQPILDLVEGRMGLIDLLNETGVLAKATDAAFVSKIHEAFSAHKNYEKVRVNAMQFKILHYAGEVTYNGEHFLEKNKDTLPPEILELLSSSKSSFIRDVFPEASKDKNKPGRRQGFLVGATIANSFRRQLGELMEQIAKTTTQYVRCIKPNSNKSPKEFDRQMVVDQLRCAGVIAAIRISRAAFPNRLTLAEFARRFDIICPSKLRKAAPEAMVLGLLEKLGITESSSQNAKFAIGKTKVYFSSGLLQYLEEQRTVVLRKQAILIQKNMRAFAKRKQFKAIQAATVVVQRRTRGWMARRRWMIVCRGMPKLQAAIRGYIQRGKYRVLVQASREEKRLRILAEAQANAQSAAELQQKLQQEILPPRSSLTVGSPYFNGEIPESPKRAAPPVTQKMKDDLVHKLDEAQAMAEQARQAAKEAMQLNAALQVENEQLKAKLAKNARDYADEDLRVENERLRSQLAALQSKIIRADEVALISAKVVDSRITYRDGKQFVEYKLQIETNNRGTLFVWHRYSTFRNLASTLQTKNGYARKEIPELPNKTLFGNFSDKIVQERIEKLNAFLEAATNADYLQWGIRIDADTCVYKRRIKNSTSRESMAMRDTMTTMSSSVHSPTASDSSTTPPESSFRRSFFSRSKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X281</accession>
    <name>A0A6G0X281_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_009452</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000119">
        <property type="protein sequence ID" value="KAF0733895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X281"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001448"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051625">
        <property type="entry name" value="Signaling_Regulatory_Domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872">
        <property type="entry name" value="BTK-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="75"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="178"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="230"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="280"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="330"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="380"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="5">
        <location>
            <begin position="874"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="689"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="548"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="618"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0733895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1090" mass="123218" checksum="C5C2D462ACDC2D5A" modified="2020-08-12" version="1">MKRRGSQPDSWPRNKGNAAFKFSKTEQAKRDFLRRLGCDLQRDDIPSQAFKSAYVLPKKQAGLIKTTALDFYSLLEVRSWGSGSHGQLGLGDDRHRPTPDIMLPIYKITNDPSRVQICCGDLVSAAINELGQVYVWGRLPLDASQNIRVPERVSGLDKVCIRQMDCGPGHMAFVSIDGYVFTWGKGASGRLGHGDEHNVYLPRSLTSPLAVSIRQVACGEEHTLLLTTSGTILSFGNGRAGQLGLGTYCNCSEPSLVPLDHVVVQIACGMNHSGAVSDGGEVFTWGWGEQGRLGHGSEEPQPSAKHVDGLRHVTTLSCGGAHSLALTKCQKVFAWGWGAFGQLGNGSCHDCLVPKAIKSLENVTAIACGYGHSAAVTDHGELYIWGFGEEGQTGTGDEKNHETPQRVISSDREGQILHVSLGKAHTMAVVLLNADTALRKRLSPENIRLAAITLQCFVRRTVARLKAHRLRCERQVHAKEKHNHDLKKLADEEGFEVERIAALERLDAERKLVEKAQAIEAQRRRELEIASATRIQSIVRRHLARHSVAKRLRQIRKVQAASERAEQEAQELATRLAVVEVEAEALAIDDIARLFLDDVVDAAEDMTLQVVEEQWLQLESAKQLKRREEMLLQQQKEEAQRRAALAEEREARRREAVEAAEAELKRRRDREIADAKAKRLARLQNQTSIPTPIPHVGETKHKRRGKEKKRDVEELNANRAKREKERAELAQQKRLMEEQLREKQQVAAKLESERHERLFRKSLQNSPTVRPNAAFHVRATYIAETSTSYRGELKPHYVLDPAAPSTDIGKDVQRVPTASKYRIFRELQRGAITNDRTYRVSKSSDGKRPSNQLCLPLYRDAAAMPKFSLPKIHRRYYTPEEVAMHKCAEDCWVVVFSHVLDITDLIAKNRGMLTQPLVNHAGEDISHWFDPDTMDVKTHIDPDRNLRLPYLPHGRFLHVPPPEPVTTWNTLDLKPWWTDDQYFIGFITQRVRMIEVVNTLTHQKHSLQVCTEETIEEIQYRYIDLQFNAHAASYTWKYLDGDEFVPLDMAKTLTENGIPDESLEFEKLNMDADEFMPILHLYYNDDLTIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X2A0</accession>
    <name>A0A6G0X2A0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_009461</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000119">
        <property type="protein sequence ID" value="KAF0733904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X2A0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005812"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF214">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="360"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="442"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="712"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="716"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0733904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="731" mass="78070" checksum="19F95640C1B18159" modified="2020-08-12" version="1">MSTASSTPCAVGKTTLTAGTNCPLTCQNTGSGVCVLYANASACVNANAKSGTCTTQSEILRHIGSSECQLTFTCPTMSQRTSDSNTKDPSWSFYVGGTLNGATSPAYVGANIEVLEDLTIPFSPSLAGGQVEIFQLTGNAFTQPKGTMQKITYPSTFFSTYTKLNRLFMFNLDLKDVLASSNSSFPANLQRIHMVNANLDSFPGEIAAMKTLTELNFTDNNLKTLPSLQSPVTTLSLAGNLLTDLTNVPSTVTKLDLSRNKLTSIPSVVFSLPLTELYLSGNGLQNVVLNSSQFSFLNQLAKLSADFTVSPKCPAGSGFEPSSTTLTTISGSVKVCVTNVTDTLSATPSPTVTAAEKSGLGTGAIVGIIVGAVVVIVVGLFFACRRRRSSGGDYSSGSLKHGDYYTDGTGGFTTDPSGGQSGSLGILNDPELLAVRINAAEVKEIQMISRGGFGEVWSGIYQNRPVAIKRLLPDKKTFDDAMAFAAEIKVMARLNHPKIVEFIGASWSNALSIQAISEYMNCGDLKSLLERSMKSGTDLPWLNVKLNLAVDITDALVYLHTLNPKYIHRDLKSRNILIDADNGAKLSDFGISRNRAADETMTAGVGTCRWMAPEVIRGEKYDESCDVWSFGCVLSEMDSGNVPYNDATNTNGGRLQDHGIMEQVSQGLLKPSFTGNIPKEILDVAMGCLEFNPSRRPTSMQVSFALRKFRKDVEKSSSTNGASRSGTSNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X2H7</accession>
    <name>A0A6G0X2H7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Myosin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_009161</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000118">
        <property type="protein sequence ID" value="KAF0733986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X2H7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004835"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012935"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00124">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF706">
        <property type="entry name" value="DILUTE CLASS UNCONVENTIONAL MYOSIN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0518">Myosin</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="10">
        <location>
            <begin position="84"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="9">
        <location>
            <begin position="994"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="6">
        <location>
            <begin position="640"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="884"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1108"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="848"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="915"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1115"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1128"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="177"/>
            <end position="184"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0733986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1162" mass="129924" checksum="6BDC9E0C7A20B903" modified="2020-08-12" version="1">MASDFGEKSMGALVWVPHTTEVWKKAQIVQKVSDTSVEVRFVSDGVEYDPEEGQTKTYDVREIAKLAGEVSATAMPICNTFEKLGVEDMCTLNHLHEPAVLKNLQLRHARFVPYTYTGQICIAVNPYKWLDLYRKELYPEYLNQPRNELPPHPFALSSSAYIDMNKNGIEQSILVSGESGAGKTETVKIMMNHLASISGGGDHGSLVIDQVLKSNPLLEAFGNAKTKRNDNSSRFGKFAQLQFNAEGLLVGARCETYLLEKSRVVGQAHGERNYHIFHQVFSLAEELKRELFIEGSVSDYAFVKVGAGSRVDNTDDSVFLQETKVAMDTIGIDAREQRGIFEIVSSILNLGEIVFKAETTEKCSVQSLNNVEAVAKLLQTKSEALQATLTHRTMAARGETFTIPLSADQAADLRDAFAKGIYSQLFDWLVTRINRAICSTRNVKHHIGLLDIFGFESFDHNGFEQLCINYANEKLQQKFNSDIFKTVQTEYVQEGIPLELVSFEDNQPILDLIEGRLGVIELLKETGVLAKGTDAMFVSKVVAAAADHKNFEKVRTNPMQFKIIHYAGEVTYDGDKFLEKNKDTLPVDLLELLASSESSFIRDVFPDLASPKSKNGKPSSRKGGGFLVGATIANSFKKQLGELMEQIAKTTTQYVRCIKPNANKSASEFDRQMVVDQLRCAGVIAAIRISRAAFPNRLTLVEFARRFDIICPSKLRQAEPAVMVLGLLEKLGISEKSTQNARFAIGKSKVYFSSGLLQHLEDQRSVVLRKQATLIQTHMRGYVKRKQFLAMKASAKLVQAVFRMHMRYKRFRVMKRGTIRLQSRVRGVMARRRFRVALAKERQRQLELKRAAEAKARAAAQKAAEEEKTLAAAAAAAAAMNNNSHNNQMDEEEPVETSSEGSDGDRMSAASQSILASAAARVAEAEAAAVEAQKAAMAALTHNRVIQAENEALRAKMAAYVAEHADAELLRENERLKHQVLTLQSKLVRAQEVSLISAKVVDSRLTFREGRQFVEYKLQIETNNRGTLFVWHRYSTFRNLATTLQTKNGYRRKDIPDLPNKQLFGSLSDKIIQERIQKLNEFLEAATNTDYLQWGIRVDQDTCVYKRRTRSSSGADRESMRVDMRESMVSTVASSDAPSPRESSRQSFSLRDSIFGGGRRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X2J6</accession>
    <name>A0A6G0X2J6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_008992</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000117">
        <property type="protein sequence ID" value="KAF0734123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X2J6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006191"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0734123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="198" mass="22217" checksum="82390D5AE2E38D0B" modified="2020-08-12" version="1">MSRNLVEGDPIASMRARYSDALEWAHHDQNIFNEAPNADSYAQAHFFELPPISAVSNPPSVPHSVISVKSRELRDAMCVPPSRPYNEMVMSALEMIFLLNPFVMDPRQWDDDGRAHAEKYRLAGLQPNARRSIHGLVHTSKGCCPVNPLHGEPAVEYTGAWVLRLSKKSERQVREILGSCAWTLEELVVYAATRKQGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X495</accession>
    <name>A0A6G0X495_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_008622</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000106">
        <property type="protein sequence ID" value="KAF0734773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X495"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019552"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="802"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="198"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0734773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1204" mass="132161" checksum="E2C46CAF24A0FEC1" modified="2020-08-12" version="1">MVDHRGRIRARQISIVNSRCRLHSPLYRNTRSTLSQSSRSSVDEYETRVERSRSPSRSPRTQRQIFFSEEIIENDCPTKDSMMEFPDVIKPSAEFVRTQTTTTTTTVVCEEQMLVESDVETNTSSIAMDHVWDIGRRRSTADSTPSSDMSHSPIEYKRNRHDFERPSYPTALAVSSGVTDALARMKLRKQEMEMSNIVEKVQKQMAAMEKVLKELQLEHSLKCDLLERQIEINSRLEREKSTLQDEVNELTRQLVALQSKKEDETGRNVNFMSLAMNSFITRSEHTQHLIVEQLKDLSKSGLNQGSLPAGGDLSAQLVLDHLSQYHSEILAALKSQNTTVLSDDTPAPQPIRRSNTLKMDENQVTRAPIQNTRAVESKVNCAQPNSFFNSARSALVGATLFAFGLGAGQVLLSTESRQPVAAQQQPSLDMDILLEKMKQSQLDMQPIVIEKWEKVVQAEIPAVVEPKTSEPVSHPEDVHTEAEPLEIAPEEPTSQATDYHAEPVKTEVTYSKPDVKSQIALLMQLHKNTEKKPAPSEPLSDVITEALKNKVVDSIDASAESKFEEVDKATEEVATIDEKVEETALDEIDEATSAEIPEEEEHTEEVHNEVESPVENEVVAAEAVIEPVEVSLSAESDLTFKVIAPIRNESSRPEEEFEAVTEVSQPLVGDVEPEYVENEEVFTQVTPADVDDAPVNDVTDEVYVAVNDEADVTEETEASSIAGHQDSELPASTLHSLASALKTLVDPSFTVKSSVSVEVKETPVKAPRVKFAGRHLFNRFEPKAKSAETVVVDRVENVLLSSTAEPEEPSDVNATSDVVNPPSEHELVQKKSIEDPVVDVASPENVEESAVDTPLPEIEQTLSNFVLDNVQTVEESVLESVSAEPVWLSPLMPEVEQMWSNVTEAKPVDDVWLSPLKTWEDEVYSNVTVASDIALATVVQVPVVEKVLLSFPSCDARNASSHKEGTSVNPFYVADIAIPEPTDIVEPIAEVVSALASVEVVESTTNFDMSAALVVSPEEFSNVSSVELPSFEIPEDVSADEPVDPKEDQHVAPAEPEIATVDEVVATSSDVDIIAETEHTQVEIVEEPIEVSSLETLPVALAEDAPVTEVIVDDGAAHEAEVANFLKEFGEVVAKLNGEISVEVEVEGAMEPAAPEPVHDIETSSTVEVETAVDVAVPTSLETEAVPCASLDKVEAFLTLVASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X4I5</accession>
    <name>A0A6G0X4I5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_008642</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Non-catalytic component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the proteasome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000106">
        <property type="protein sequence ID" value="KAF0734794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X4I5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001507"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03759">
        <property type="entry name" value="proteasome_beta_type_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000032">
        <property type="entry name" value="Proteasome subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033811">
        <property type="entry name" value="Proteasome_beta_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF10">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0734794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="204" mass="22515" checksum="1F7E8FCEF24EBB2D" modified="2020-08-12" version="1">MSILAYNGAAIIAMAGKNCVAIASDTRLGVQGQTVATDFQKVFRLNDKTFVGLAGLATDVQSVSQLLRFKLNMYKMREEREIKAKTLSAMISNMMYEKRFGPWFVEPLVAGLTEDNTPFLSSMDCLGCEMFTKDYVCAGTMEEALHGMCESLFRPDMEPEDLFETISQCLLAACNRDALAGWGGVVHILTPQGVTTKVLKTRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X4I7</accession>
    <name>A0A6G0X4I7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FCP1 homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_008510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000103">
        <property type="protein sequence ID" value="KAF0734846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X4I7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010387"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38899">
        <property type="entry name" value="DOMAIN OOKINETE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38899:SF2">
        <property type="entry name" value="FCP1 HOMOLOGY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0734846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="232" mass="26403" checksum="79A575C26ED0A04E" modified="2020-08-12" version="1">MRGPTTLAQPPISVPHSPRPSSMRVPSTIILLDWDDTLFPNAYLSTKGYSIDDFQQPLTTADEALMDRLTQHIQIFLLACKDAHRTVWIVTNGEDGWVERSCKRFMPCLYPLVTSLRIVSARALYEAKCPMQEWKTACFVAELKQHFSSDVGCETRHIVSIGDSQYERQAVQVVPTRLPRTKTKSVKLVDQPTIVDMVRQLKLLSTYLSHLCSHPDHLDLILSREVLRDISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X4U0</accession>
    <name>A0A6G0X4U0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_008575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000103">
        <property type="protein sequence ID" value="KAF0734914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X4U0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021236"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0734914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="179" mass="20461" checksum="3C67773FE7756A3E" modified="2020-08-12" version="1">MHAAYSPRFPQDERPPFRGYCLYKTGKCPNERALKTNGQPHNLCDVHRFKQNQNQRKMDWKLRQKRYFAPYERSETHVVQKVPRYTDTTLSVISLPPIVSADPYSLPWPTGPVPFGLDSFEPDHSSPRLYYKISNVLTQETAPFEPWLSQPVVVSSTPPRLPSLAACISRQAVAYGDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X5L9</accession>
    <name>A0A6G0X5L9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_008181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000100">
        <property type="protein sequence ID" value="KAF0735266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X5L9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015506"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052745">
        <property type="entry name" value="G3P_Oxidase/Oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42720:SF1">
        <property type="entry name" value="GLYCEROL 3-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42720">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0735266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="422" mass="45869" checksum="3306EB6541E5A08C" modified="2020-08-12" version="1">MQVFDMAVIGGGVVGAAVFRDLVLRGYSVVLLEKNSNLVHGASCGNSGIACTGYDAPEDSLERQCIRRAMLLNPKVYRELGLPSAPVGSLVVAWTQEELTALPHIIEANHNIGDKEVRLISKEELYNLEPYLAPGAHGAVLVPGETVIEPWLLPLAYVHHGIANGGSVRLEYEVNSGAFSNGVWTLNCAKHSPVQAHYVLNCAGLYGDIVERIHSPSVPFHIRPRKGQYVVFDAPDLVKSIIQPIPTDRTKGVFVFRTLYGHVLVGPTAEDQEARDTAVNTPEVLSMLRQTAVKIIPALSTRPIVGSYAGLRPATEHRDYQIDFDQARHWVTVGGIRSTGATASLAIGEYVGSLVASAAPPRPKQSVVEFRLPSLQELADHHLDISSNTMQLGELRHALTHPISRFGLVKLRDPSLKPTSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X602</accession>
    <name>A0A6G0X602_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_008239</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000100">
        <property type="protein sequence ID" value="KAF0735327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X602"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013911"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40849">
        <property type="entry name" value="C2 CALCIUM-DEPENDENT MEMBRANE TARGETING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40849:SF2">
        <property type="entry name" value="RGS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="285"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="330"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="425"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="455"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0735327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="505" mass="57420" checksum="88DCB5B9992C4DB1" modified="2020-08-12" version="1">MQRQKWVLQVAWGAAAFSASVAVFSLIMETQKEDDDDEGTPLLTNGEETQQATAPATVTIASINAALNPMHLSFVQRARVQSFWDELSSSIPNDAIPVPVAAAQIQVYAQRYPEEFPLPQMTHALSAITSGIPAVSVPRPVSRRRSTLSLVGNKLFEMAVDTKGGMQDAMHRAVRRYLERALDLFAERLKEAIKDKDMPEYLQTHIDVAVDQFLPDVKVELFRKTKDLFTTTTAPVVPANTPIDAVAPLTFIATMYMLWDQARACILYNLFPYDHSIWKSLKNPLWWAFNFVGLLPYVGQVWWCYLFLLKDKKDEHQLCQFIIGFKTTQFLTLGLGATFLGIMRYIYCTMLGDTCDVYGPLLSPWNTLFFLGQIALVWIAFFYLPYTERPATTVVSPRGAVRSSTYQDMFGNILHMDRGGYLMKLCGYETITFCITMALALAVNMAVTLTWQRQMLMFWIRTLYGLLSFPFLPFKIPVLENVLMHTCRMGYDERGRTVRVRVKMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X651</accession>
    <name>A0A6G0X651_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH myb-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_008132</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000098">
        <property type="protein sequence ID" value="KAF0735446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X651"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011973"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006447">
        <property type="entry name" value="Myb_dom_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01557">
        <property type="entry name" value="myb_SHAQKYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12802:SF155">
        <property type="entry name" value="DEUBIQUITINASE MYSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12802">
        <property type="entry name" value="SWI/SNF COMPLEX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH myb-type" evidence="5">
        <location>
            <begin position="14"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0735446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="126" mass="14745" checksum="B41A8A7E416C2051" modified="2020-08-12" version="1">MPRANKASEENASNGGRWSPQEHKRFLLGIKLFPNGPWKHVAAIVKTRTARQLRTHAQKYRAKLARHQQRIKWCAVKGDERPEKSPWDLVKKARIEPIEFENTAVQYDDCIEFLIDAFRDDLPLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X8J5</accession>
    <name>A0A6G0X8J5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_007293</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X8J5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002314"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19076">
        <property type="entry name" value="AKR_AKR13A_13D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF40">
        <property type="entry name" value="ALDO-KETO REDUCTASE YAKC [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="33"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0736272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="346" mass="38090" checksum="62001079EC102310" modified="2020-08-12" version="1">MVQVPQRPLGSQGLVCSAQGLGCMGMTSIAYGSFDRVAHEEESLRTISKALELGINMLDTAWIYQSPGLPGQPNFTNEELVGKAIKQHGRDKFVIATKFGFVPQADGSTIVSGSEETIRSQLADSLQRLDTDYIDLYYMHRMDPKTPIEETMAVLTSLVEEGKIKYIGLSECTPDELRRAHAVHPITAIQMEWSLQSRDLEEAVVPTARELGVGIVAYSPLSRGFLTDIKAFDKLDAEDRRRTLPRFNQDKLAESNAKVARFFELAKEKNVTPAQLALGWVHAQGHDVFPIPGTKSSTRIVENAAASSISLSAKEWQEVAEAAGSINAERHFPFAASINFNARLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X8V0</accession>
    <name>A0A6G0X8V0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA/RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_007508</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X8V0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020103"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005697">
        <property type="term" value="C:telomerase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018834">
        <property type="entry name" value="DNA/RNA-bd_Est1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019458">
        <property type="entry name" value="Est1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045153">
        <property type="entry name" value="Est1/Ebs1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696">
        <property type="entry name" value="SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696:SF0">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN EST1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10374">
        <property type="entry name" value="EST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10373">
        <property type="entry name" value="EST1_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Telomerase activating protein Est1-like N-terminal" evidence="3">
        <location>
            <begin position="58"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="DNA/RNA-binding" evidence="2">
        <location>
            <begin position="164"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="585"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0736498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="616" mass="68844" checksum="5476FD9EBD84A840" modified="2020-08-12" version="1">MDPPSLYRDVMASESALRELLRSQACGSPNALYLRSTLMEKAESFVSKCPGFAASKEIEQVLWKPCFYKRIEDFRRRIRKYASQSGNDRSIRDHFFKLSDEFQAFLDQSAAYYERLHEYFVAADPTHDGEALRHSMFRCLIFLGDIARYRELHSQKAKKNFIAAEGYYHRALQIMPENGNPHNQLAVLATYIEAETIAVYRYCRSLLLPQPFATAEENLSLLFERSRHRALSPTSSTSISAQSPPKEKSAFLKAFLHRLTRLHGILYAPTVDETYPLELEASICSDFQALLAAGVLGDALVLKLFVINIFCITRSSAMQANAVKLTLVLMSIVLDCVVEKRMLLGPVSVLGDFFRLHPRYLDVAPPSLEWKTSLVKVLNECCVVYAASHEEYEANKGQLKESIELRCFEPLGTIPNSTGSTGAIPEADAWPIRCANLLRFASFLVHERILYERDGQYSTTPPPPSIPTIMPPMPSIVDNGRGMEDEDDFDDEVIVFQPVESQQSASSSAFIGSPSFGSVDLSAFRNLGGGLRPMATQDVLWQPNAPSSSASVWQEPSWTHLEAVEQESSRYEHQASSLSLLFEQTSQSTKKTTKSPPPGFAPVVTRNPFVVGGHPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X8Y4</accession>
    <name>A0A6G0X8Y4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitogen-activated protein kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_007412</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X8Y4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021248"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07834">
        <property type="entry name" value="STKc_MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000439">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000046">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="723"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="8">
        <location>
            <begin position="1071"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0736393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1106" mass="123615" checksum="55B5A698749EB0B8" modified="2020-08-12" version="1">MAAAVESTKPKSGARIRTQSDCYTSGERERAWRKSLVEELGLDESFRASLNGIASTGGRLSLGASLERVDIGRLSETATEILSDAKVIKGGNEAKLYRQSLCLSDEGRVSITEDSQDVQTMLEDAKEAAEMGEIDEEPREVQPLTPELIEWEGVLSKRSEWLRRWEKHYYVMVGTTLKRFASKEAFTATLQESPVEGKPSPPSYVIQGVKDAPGRANGFVFTCHDGKTLQLTAPTAIEKVIWMRLAQEAMVSLPDLPVYPLEIEEFYAMLIVLYTAYSGNWRTSGDMAVTLPPPSEQVFSRFFRLLDKDILVSSNYPPSVPFCGSYRGASGFVQFLHAFASHTTWTNFKVEGIAMEDNVAVASGKEELENVRDRRKFVQNWVHKFNFAPDGRLIKFEINGDVVAASAVYKIPGAATTLTLPQDFHEVQTPLTGILTIRVLQGSGLKYIPHTTSSSTAAKKTPIALQDPRVVLSLSVGDPQTSLLPPPAPTTSASSYLPISVPLPSTLTRKLSSTGLLRSVSAPVKSAATPTPADVMTEAARNKGQSTDLSAPVWNAVLTIPFDQVQGGVRLLVDVVEMHPTRMKVGMAFVNVAKYLMEQETKQTSQWVTISSTKGEFCGRVQLSISCVLQSSKAVTPNVNHLMQWNMKKDDATPSLNRPGWSQMHLNTNTTTINENGQHQEKVPSPEAALASVDPLKPKICEDDPSMHVYTVCGAPFVIPQHYQLIKVCGRGAYGIVIAATNQETGGSVAIKKVIDCIWHPHQLKQILREVRLMRHLCHANILSLMDLIPPPSYQDFRDVYMTVDLMEMDLHRIIYSKEVLSDDHIRYFVFQLLSGLSHMHACGVLHRDLKPSNLLINSDCQLKICDMGLARPKDMDDLGMTEYVVTRWYRAPELLLGSAYDEGVDVWAAGCIMAEMLGRKPLFPGRSYVHQLQLIMNVLGVPEEHSFKENPQAQKFKGRQLLSRTPSRQGIDTSLLFPNANPEGLDLLWKLLVFDSTKRMTVKEALRHPYLASYYVESNEEQQVEKFQSFDFEDLGENDLKELMFREICHFHPEEMEKRAKQMAEMPREEKLPPGWVKRESRSIRGKFYYSHAKRGISTWVKPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XA42</accession>
    <name>A0A6G0XA42_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peptidase M14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_006803</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000085">
        <property type="protein sequence ID" value="KAF0736992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XA42"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015642"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000084">
        <property type="entry name" value="Carboxypeptidase B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF143">
        <property type="entry name" value="SLL0236 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026025989" description="Peptidase M14 domain-containing protein" evidence="11">
        <location>
            <begin position="25"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="12">
        <location>
            <begin position="70"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0736992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="355" mass="38826" checksum="FA7C4A6FFD1683CE" modified="2020-08-12" version="1">MGSIAWLALLLVVQSATLLALTTARQSTDPDSSQDASQQEVVDIAACHKRSQARMNQSAVVDGLHPFFDCFRSYKQVDLFLEGFVASHPTYISKVHVTTTVEGRKVFGYKLSSGAEVSRRVLYIQGGIHPREWIAISSTVYAIVKLALAHFDVVVVPLVNIDGYRFTWASPTNRLWRKNSHGVDLNRNFGPVELFQLSDDVGSETYPGPSAMSEPETQGIANYLTTLPSLSGTLDIHTNAGMVLRPLSVKREPLEGDHETKMERVGAAVAEAMNGGHGKYVSLPGYELYQGALYAGTFKDMVYLSLRQTPSLTIELKGGDGFIAPSSSIRPAGDELVEAIHAFATQMLEYDTIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XB72</accession>
    <name>A0A6G0XB72_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_006488</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XB72"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010616"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0737318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="187" mass="20769" checksum="F83595E6DD38EC1E" modified="2020-08-12" version="1">MFARRLLRVAQRPIRRGFSSQGPAPHSGANDNSSFFQLLAMGSFVGLSVYIYRDPDVLPESIRKFMPIQKPEGKSMTLEEYEAWRAKQSTPSAAPAITGEKKNVTVQVDEAPTIEIDPTEVVAPHSKAPETKESLQQALELARSNESTFLAELKASKAPLTDEDKELLQAFRNEKARIKKELKALTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XCJ3</accession>
    <name>A0A6G0XCJ3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_005916</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a long chain fatty alcohol + a fatty acyl-CoA = a long-chain alcohol wax ester + CoA</text>
            <dbReference type="Rhea" id="RHEA:38443"/>
            <dbReference type="ChEBI" id="CHEBI:17135"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:77636"/>
            <dbReference type="ChEBI" id="CHEBI:235323"/>
            <dbReference type="EC" id="2.3.1.75"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the long-chain O-acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0737920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XCJ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020010"/>
    <dbReference type="UniPathway" id="UPA00282"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047196">
        <property type="term" value="F:long-chain-alcohol O-fatty-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045034">
        <property type="entry name" value="O-acyltransferase_WSD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009721">
        <property type="entry name" value="O-acyltransferase_WSD1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004255">
        <property type="entry name" value="O-acyltransferase_WSD1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31650">
        <property type="entry name" value="O-ACYLTRANSFERASE (WSD1-LIKE) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31650:SF1">
        <property type="entry name" value="WAX ESTER SYNTHASE_DIACYLGLYCEROL ACYLTRANSFERASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06974">
        <property type="entry name" value="WS_DGAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03007">
        <property type="entry name" value="WS_DGAT_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="O-acyltransferase WSD1-like N-terminal" evidence="9">
        <location>
            <begin position="114"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="O-acyltransferase WSD1 C-terminal" evidence="10">
        <location>
            <begin position="325"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0737920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="472" mass="51905" checksum="9F152A7594317564" modified="2020-08-12" version="1">MDASLAFLDGPTPSALLASSPWTLPMTFIVALSVFWAFLLPLITLKSTLPPQKPKLKRRMTSTGLTTLLTETETNQSILFTMTILDKIITRETFVEHLRPRFDSEFFVRFRSIIVGRSFVLEESFDVDDHVHFHTLAEGETAHSYAESLNNAPLDPSKPLWAVHLVHEDGKTYALWRSHHCLGDGQSMAMFFLKLCDNGHEIEAPGAAAPEAKIPLVTRLVLIAWSIALYLYKVVRTFGIPESTQFFKRPGHTKKHLAYSLNMSVDETKAVGKKLKASINDVMLSSVASALHQLVPESERSSKMFIRAGIPISMRPSSDPFVTTSNAFSSLLIDLPIGDTDGVRRTKKVVAAMRDAKFSLEKDITLLLTKFLSLLPEAVMVPMARLMASRVSVAVTNVRGPPNEFYLAGAKIIHSLGFVPPPPSVNIGIAITSVGNTLGVTAATDKSIDASFLIRAIESEFQVLKATVMADN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XDE4</accession>
    <name>A0A6G0XDE4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_006177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0738201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XDE4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017062"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0738201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="173" mass="19015" checksum="BC793E65CFF105B1" modified="2020-08-12" version="1">MIDWGNTDTVRDRRKREQAYQERHAQEKRLRGSANEEKTSDEGSGTSADVEMAITASSGTTGGNRQDGSETAVDPFYAPRLRPFNDTQNTILPFYKTGTINLGTSDGAIAVGNFAIRLNSIWDCITVPTYTEDPNPATDTAGAIGQIETPILAEYLSLLDRRWFSLQGPLLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XE52</accession>
    <name>A0A6G0XE52_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_005850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000077">
        <property type="protein sequence ID" value="KAF0738292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XE52"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012111"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="208"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="328"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="388"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0738292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="431" mass="50913" checksum="CAEDF0AFF0E11473" modified="2020-08-12" version="1">MKWRSSPYTVGGAALLKQEKAQITELCRIEVEETKAILDKQLAREKKRYKKELEEREKKSEDFCIMLRTRYETMLADQDLLHQTQLTQIQDLIQRTYISFTDHKRILSQRENDWKSEQDKCIQHLKSDYERLLHDIVQEKEVALQKMHQNIVEPLRAKADELQKQCKYLKKQVDRSSKELLRQTNIAHDEMLRKTQMETEVREACRHIATLRSQLKKSNAVIRDLKHELQRSRQEAKEKSGALGALQLEMASAQAEIHSREICLAQEITHLKQSLEQHDKAKHEMEQEFQVLKKCLAECQILRGDAETREQLAMQRITLMQTTAESTTSNLRQQVQQANAQNKELNTANHKLHEILIYLRQKMQELQCQLSTAASSKEQQEVIWKTKHELLECQHRESMSELEALRLENTNLKQEWRVKHQVLAERKLSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XHE0</accession>
    <name>A0A6G0XHE0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_004789</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000063">
        <property type="protein sequence ID" value="KAF0739614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XHE0"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="42"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0739614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="89" mass="10959" checksum="1B890FF643B2A8E1" modified="2020-08-12" version="1">MKASSKRKKTDKEHESDTPTKKSFLLDYQREELVLEREKVAFEREKLMIETQEKERDREERKEVREEQRKHMEQLLELARSCIDRSLHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XHG9</accession>
    <name>A0A6G0XHG9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Endo-1,3-beta-glucanase btgC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Laminarinase btgC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ae201684_004769</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation. Active on laminarin and lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000063">
        <property type="protein sequence ID" value="KAF0739589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XHG9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012928"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF17">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE BTGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="400"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF0739589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="428" mass="47087" checksum="61FBDAFF29DCAA9A" modified="2020-08-12" version="1">MDKTLTLYGTGSSVWSDIHHPFGNSSFFKLPPCPSAVSQLQVMQVVRFAFAALISLYTVGAQNTPSPALGACYSPFHLAEYPLTGPGSAEAVPTGIEADFAQMAKLKFTQVRTYYSSYFGHDIAPLAAKHGLQLHLGVYMTYELWYQNQVDSAVKAVKAHPKTIKAILVGNENVAPYGRYAADDIVAKMKVIRDRIKNETGLSVPVGTVQRVAEWLLDDPKIKKLAANSDILGVNLYPFFDNSFDPTKPAAVLDSVWSVLTQRYPLSKLRITETGWPSGGSPPSFAPKNVPNLANAKLYYKTFLAWMASKGRQGDFWYNMYDSRPDEKLPADVEYHFGLLTHKRDVKGVLKLDTSVQNDATLDRQFNGPNVLLVNSTLNLTIGTNQSVAASETIVFPPSSRASDGDNTPSMNQAYDNDEILLPSSEQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XHS2</accession>
    <name>A0A6G0XHS2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_004605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000060">
        <property type="protein sequence ID" value="KAF0739831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XHS2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014240"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026277552" evidence="1">
        <location>
            <begin position="19"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0739831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="227" mass="24864" checksum="81EFD3B043B1422F" modified="2020-08-12" version="1">MIRGAVLLLLGLFNACDAGSIASAFCNDKNTTTPIVKGDQTYICVNINDSYRVVFAPVVDKYVQLRLHDSYVDSRLKTTGNSSTFMTISSMASRSVYKMYTNSKGKAYPILTAVVTVKQGEIQGISWDDGCYLCDYAECDANIYSTPYSPLLNSVLGDGSTCYHTPIQCANTTGLCDLAIYIGWTGTDANGDYLSSAGMRISQFQKYSVTSYLNDFQSKLTSLLPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XI19</accession>
    <name>A0A6G0XI19_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Long-chain-alcohol oxidase</fullName>
            <ecNumber evidence="5 12">1.1.3.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ae201684_004671</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Long-chain fatty alcohol oxidase involved in the omega-oxidation pathway of lipid degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>a long-chain primary fatty alcohol + O2 = a long-chain fatty aldehyde + H2O2</text>
            <dbReference type="Rhea" id="RHEA:22756"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17176"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="EC" id="1.1.3.20"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.20" evidence="5 12"/>
    <dbReference type="EMBL" id="VJMJ01000062">
        <property type="protein sequence ID" value="KAF0739785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XI19"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009670"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046577">
        <property type="term" value="F:long-chain-alcohol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00636">
        <property type="entry name" value="TroA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012400">
        <property type="entry name" value="Long_Oxdase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46056">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46056:SF12">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028937">
        <property type="entry name" value="Lg_Ch_AO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="15">
        <location>
            <begin position="208"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="14">
        <location>
            <begin position="258"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="16">
        <location>
            <begin position="552"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR028937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR028937-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF0739785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="766" mass="84265" checksum="85DE1BF1E3A6037B" modified="2020-08-12" version="1">MRRLTDQQNATVLAISEAICGPLPKDIAAGVVSDHLHTLRKFSNGTVPEQEESDLFNLTQVDVQEVGVLHSMEVLLHKLPEDKWKELETVFSLLNTGWGTELVTGAARMVPFHQLTLPEREDALRNLARSRMSKFRSLFLVLKDLITFCVFSKTRTIHGHPNPFWNALNYAGKPEEAERPPRSAFWEPKFEDVKAMAASGQPIEIETDVVIVGSGAGGGVIAAELAKAGHRVLVLEKASYYNPADASFHELQSFMDNFENSSVLATEDASMMLFAGSAWGGGTHINWSASLRPPLAVCEEWATKYNLPYFGTPAFQEAIDAVIARAGISADHIKHNAPNQLLLDGARKLGYPVDAVPQNTNGHEHSCGYCTLGCPYGEKQGTHVTWLKDAAEAGAKFIDDCYVDKITYSDAKEVTGIVGKVLNGSVQLIVKAKTVVSSCGSLNTPALLLRSGLQNPNIGSHLRLHPVVTLHGFFPDREIQSWKGSILTSVCNVARNIHGNGYGARIEITASLMGLIAAFLPWRSNADYHRLMMQYPRMVSMIILARDLDSVSSISIDSTGRPRIHFKLGEKDSISHVEGLIAAAKILLSQGAVEVNSSHFDLPPLQLRTPEELENPIECATTQKWFEQLRKLGVQQNRLGIVNAHQMGSCRMGDSPDTGAVNPDGESWEVKGLYVGDASLFPTASGVNPMLTTFSIAYSVAQFMKANLSDKTNASLKKFPVAKPWLRLSNSTARTAKWLVVFLSFWWRKRIWTLVQSLFSHVKTIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XIH8</accession>
    <name>A0A6G0XIH8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_004383</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000054">
        <property type="protein sequence ID" value="KAF0740146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XIH8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013407"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF214">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="135"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0740146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="405" mass="45533" checksum="AF1CD0090F9F807A" modified="2020-08-12" version="1">MASATFGLATSEQRVLSEGDGTNIAVIVGPAVGGVVLVVLLVWCCCRRRKTRAASTAAEVNEPAPSQRRRTQTNENVQVVAHNDYIQVERQVVKDLPPPKTELSLNPPNPVMEDEQDEVATEDVLHAHRLREPLILLEQVLGRGTYGEVILGHYNQQLVAVKRLRPDHNTPKNIASLLQEIQLMTRFNSPYLVHFIGATWENEAMTDLMCVVEYMEQRDLQSYLARTKDRPKSNFPWKQKLSVARHMALALVYLHDQKVIHRDLKSPNVFLNQTMDAKLGDFGIARHVVEKSMSNAVGSYRWTAPEVLKGKYYSVKADIYSFGVVLSELDTHVVPYAGMVNEKGQELGNFTIMFQVMNGAIRPAFSPTCPPWLHKLALRCIAFDAATRPTAREIVREIDEQLALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XIM7</accession>
    <name>A0A6G0XIM7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_004537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000056">
        <property type="protein sequence ID" value="KAF0739956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XIM7"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026338114" evidence="1">
        <location>
            <begin position="16"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0739956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="101" mass="11414" checksum="13F9CC472C5DAFA2" modified="2020-08-12" version="1">MFSLLITMAINPTSACDPTSLYDNPIELSNIEKALTHLPEQNWHLCSRDWIAVIAIFYVVLVHPLNLDSGASKLCLLEPTRQYKMAHYCSMYINSSRSLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJF8</accession>
    <name>A0A6G0XJF8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_004046</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000051">
        <property type="protein sequence ID" value="KAF0740499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJF8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010909"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23106">
        <property type="entry name" value="EGF_Teneurin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026001637" description="EGF-like domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="229"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0740499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="342" mass="35615" checksum="989A71709F82E6E2" modified="2020-08-12" version="1">MRWFACLLSTALALDATTSTAPTTTAMPRRPGYCTATGRECKSFGTGSDYVCVAVESNVPELFGLAQCVKQVDDRGSNICVGDQAGICPTFGSWPSTYRVAQPICAFVNVPQCNQRTTTASPSRLLQANTTKGTSLKCFTSNFQLANGSTTTIRGIYKCVDSTVYRQKSLGFDLTNKQLQACAGNGTSNFNAALCNGHGTCSPKSQFNSEYECRCNTGYDKKDNCFLPVGNVCDALGQCGALGQCDSKTGECICKPGSKGAQCSECDPAAQTSTVCSGHGTCGIDGKCVCTAGHGGAQCEVFSFRTPAPSTSPVPATPSSDSTAATVVTAASVLMAIHALSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XKA8</accession>
    <name>A0A6G0XKA8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_003903</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000045">
        <property type="protein sequence ID" value="KAF0740773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XKA8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012860"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0740773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="428" mass="47839" checksum="E7D2106CA04C3EA8" modified="2020-08-12" version="1">MNAKAQDIPLLFDLDPDTNLHVAVTHDTALRSFGMQLRQTQLAQTDWVCLGCFADPAVSTANQEAQSRLTLDLLMHHAVQPVHDAGLPAQLIMTHFISRNHLHAFEVLSREATSEIEGTFKGQVHSRTEFDPFSPSQHLVCNLVIQFNKIHSLMSWLCCNRNTELKLGCPSMSVQKATFSLKVLPWLPPPPPAKTLETSSSCDSLLEEVIDEPLPDLWDLVDTTPTAPSPTSIETVSWISKPALSMQHISFVDTCGHPLVFNSMYYRNNKKGGIRNLRCFPQCKRGRHSTNSFCGGNLRIQIAESPDDNELADVVVFARFRNNVEPIDELSPRLIVPEATIFRDVRSKENPKAMWMQTKFVKPRLYEIRPAGRSLSWHYGFPSAIMQKSNLHFVEVALFVPDAPGASKCIGVGQSPPFRVASSRSKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XNN4</accession>
    <name>A0A6G0XNN4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DAGKc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_002776</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000030">
        <property type="protein sequence ID" value="KAF0742102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XNN4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000189"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001727">
        <property type="term" value="F:lipid kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF31">
        <property type="entry name" value="ACYLGLYCEROL KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAGKc" evidence="2">
        <location>
            <begin position="338"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0742102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="692" mass="76769" checksum="0A8B3D3430C4A7A7" modified="2020-08-12" version="1">MTNDVAIQSPSDPTKGQKDADNATEVPPHAVDEAFERKDISTDDIPSVDEKMIETISPTQGRLEDRLDKTNTVKEPEEEKMIEHSKTNLSTSEDKIDASTNCANTDKMSSVSLENTHEDEKTAKETASNAHECEIARDKGPKSTPKLDESELQGEMNDVPNTGGLSFSPRNEKEVIWPTSGSSPTNYSMHALASNAILSKQLSLPGLFSSRALDCVREMHAYNLSPFPSPMRTPLTLKFPLHRMAGAAALVADGLYWGKDNQHLQLLISSNDLLGATLRPKQNEFAVHYMLPGRGIHERALYRRYKTKRFKASTAIAATEWVKAIQNAVKWLARVPLDTARRCKVIINPHSGRRKAPWTWNKWKPFFALADIACDVEETTHANHAFEIAQTFPTDGNYECIVIVGGDGTANEFLNGLMSRPESEWRTLVSTTPFAFLATGTDNALSLGIGVPTHMAAIFAIVKRKLRSLDALAIQVTPNGPTTYAYCGASLGLPADVAKDSESHRWMGTWRYAYLKVKHALGGQRYVYRLHYVESSTAPSPLKTFYELQDAAHQHTVEQRSLYGSSSHKEWLGSLERPSEVHHTTDDGTFLFVGGVNLYFDAKYSHPSDGQIDLVGIRRGASWIQTGRALWRANRGQPDPLLLYRKVEAVDIWPQGEHGKVYVNVDGEAVEATPGVVRIHVVPRLLCVLSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XP32</accession>
    <name>A0A6G0XP32_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Ribosomal RNA-processing protein 8</fullName>
            <ecNumber evidence="13">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ae201684_002885</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Probable methyltransferase required to silence rDNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
            <location evidence="1 13">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the methyltransferase superfamily. RRP8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="13"/>
    <dbReference type="EMBL" id="VJMJ01000030">
        <property type="protein sequence ID" value="KAF0742220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XP32"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014032"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2150:FF:000001">
        <property type="entry name" value="Ribosomal RNA-processing protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000068">
        <property type="entry name" value="Ribosomal RNA-processing protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2150">
        <property type="entry name" value="Ribosomal RNA-processing protein 8, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007823">
        <property type="entry name" value="RRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042036">
        <property type="entry name" value="RRP8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12787">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12787:SF0">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05148">
        <property type="entry name" value="Methyltransf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="5 13" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="8 13" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF0742220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="287" mass="31776" checksum="E9E5BCE7693C21B2" modified="2020-08-12" version="1">MTKSKNQKARRDASVRGFKANKAAKKVAKKMVQKSKAVVVPANSNAGKKPTATPGNKAGGKVAKGLSAMQEQMKKRLEGGKFRMLNEQLYTTTGEEAFEAFQAEPELFDTYHEGFREMAEKWPTNPLDKFIEYVKQHPKAVVADFGCGDARLAASVSNKVHSFDLVSRNENVVACNIANVPLADASVDIAVYCLALMGSTLVEYLLEGRRVLKPNGVLKVAEVKSRFETPSLGGIPGFIQRLHDLGFDLKHKDESNKMFVSMEFVKTKRAPKTNVSIEMKACEYKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XPI1</accession>
    <name>A0A6G0XPI1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Gamma carbonic anhydrase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_002747</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000029">
        <property type="protein sequence ID" value="KAF0742346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XPI1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016010"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04645">
        <property type="entry name" value="LbH_gamma_CA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047324">
        <property type="entry name" value="LbH_gamma_CA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050484">
        <property type="entry name" value="Transf_Hexapept/Carb_Anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13061">
        <property type="entry name" value="DYNACTIN SUBUNIT P25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13061:SF29">
        <property type="entry name" value="GAMMA CARBONIC ANHYDRASE-LIKE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0742346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="26449" checksum="DF7B43DEBFBD5F6C" modified="2020-08-12" version="1">MQALGKSLRALGQSLDKVGVSLEGALSYTERLVPSTRLVKNAGHKPVLAETAFVAPNASVIGEVSIGQGSSVWYGATVRGDVNHITIGENTNIQDQAVIHAAKIQNDFPTIIGNNVTVGPNAIIHACKISNQCIIGTGAQVLDGAVVGENSIITAGSIVTQGKTVPAGQLWSGVPARPVRDLTSEEIEFIKQCALDYVELSQAHAVEAAKSFEEIEADKERRKILDTVGELGFEQKPTERTDAGLFFKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XPK7</accession>
    <name>A0A6G0XPK7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline transporter-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_002526</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Choline transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000027">
        <property type="protein sequence ID" value="KAF0742424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XPK7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002387"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF4">
        <property type="entry name" value="PROTEIN PNS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="468"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0742424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="533" mass="59092" checksum="1B3361F6B6667C5F" modified="2020-08-12" version="1">MMQSIDVHDTSIPDEAELEDLNLNSPTGSMGDTESLIPLDAATSKKLYGNVKKHIPSLSIPLWNKDTQYVGLYALQVLITIIAVATIEHRSKAKAAAAAFSNQTQKEEIIIPGNEDMADRGVPYIGYMVIVGTCYSLAWIFVFFRLPKDFYIRVSTLSSFVGLVPLGLVLLFSGSWGGFFLGIGVSLLAFSDWIWTRKNKLGFDFVAVVFELVASVLLDLPTIIVAVVGVLIGGATWAFWCGQLLADVREDEGWSLNLLWLFFHFYWTSHLFHTLISIIVSGTVMYWYHHWDTSDVGSPVPSASVTSSSPPHRTGSNDLIDGVRSKKGRASTSMVVLHYFRMALSYALGSACLGAIFCPVAHLLWNILRMAKRDDSFRWLRVIVRPVATSIEGFIQLYHKYSLVFVAGFGQSFSTSAADAWELMQERGVEAIVDDDLTSRLLLFVANGCAGCMGTLCNLVLVGSHLRVYGTIVSFLVGYFVCQAATTMMNMTVKTLFICFAVNPARLAKLNPIIYHRFMRLSELKTFGERRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XQN8</accession>
    <name>A0A6G0XQN8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="1">PPIase</shortName>
            <ecNumber evidence="1">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_002241</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="1"/>
    <dbReference type="EMBL" id="VJMJ01000023">
        <property type="protein sequence ID" value="KAF0742844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XQN8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016344"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000050">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF553">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0697">Rotamase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="3">
        <location>
            <begin position="82"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0742844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="247" mass="27076" checksum="152FB81119FB658C" modified="2020-08-12" version="1">MNTTNRRGQHEPNYTKYIMGVLATLMVVYFIWMQRAFAPSSPLLKATVEEGKETELAAAVASTTKPSVVRSWTRKPGRRYVWIDVEIDGVAAGRVTAELYMDIVPATAENFRGLVTGDNALGYTYKGSKCHRIITGFIVQCGDYETGKGYGGKSIYGGKFDDEKAGLQLKHNKRYVLQMANAGPNTNGAQFCFMLGPAPHLNGHHVVFGEVVDGFAVVDKMESSGVKEDGIMLNHNVILKDGGEIFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XTV6</accession>
    <name>A0A6G0XTV6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_001519</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XTV6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018319"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046959">
        <property type="entry name" value="PRK1-6/SRF4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48007">
        <property type="entry name" value="LEUCINE-RICH REPEAT RECEPTOR-LIKE PROTEIN KINASE PXC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48007:SF4">
        <property type="entry name" value="LEUCINE-RICH REPEAT RECEPTOR-LIKE PROTEIN KINASE PXC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026154269" description="Protein kinase domain-containing protein" evidence="3">
        <location>
            <begin position="27"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="371"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0743876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="652" mass="71066" checksum="E42AB350E9F722BD" modified="2020-08-12" version="1">MRPSRRSPLLARWMIGMLVSMTAVHASTNCTSALMAANDTWCLGCQDYCFPVCESIQIVVNGQDPHTNTQANDVINTNVSTSLALTDSATTFPKFLSISATNGHSFTFLFDTVRNLKQLSTIVLDNVFVVSARPENFIASSQLSNITIFNCISPLALDLSSLMSLKHLTVQNCTLKAFPVFYPSLTLQTLHLISVNLSEFPKALPSFTPSASIDLSGNRFNAISAVDCNVISQLDIKIDGLGAANCPESSFTGDSAASRPYLAPPQSTSEPTEAPASSRTNPWNTISTIIIVLVLTSMVVVFVVHRRRLLNPSLRTPGAESAAYLTNSTPMIEGNDILLSKKKEELLSETLLTPFPPAYGRSYALLPPKDVKVLRRPKASTAHFVAQYQSATVTLHRLDFRDHEQWRIDYFLHQTELVATLQHPNIVRLVGATKLSGISICAVFDITSTDETLPAFLFAAAKPDSSRTLTWSQQVAMALGLAQGLAHLHTKEPLPRTLSSNDILVRDVTCRINTLEWMDVTTEDSQRVTEYGQFVMASTAPEVLRRRRLPQDATDAVIHTRAADIFALGIIMGEIATCGRPFASWIDAAGPVAADAKIEALYVDSDEEIAPFGTLEQDRAFHDLVAQCLSRDPAARPDANAVVAALEACQVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XUH6</accession>
    <name>A0A6G0XUH6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_001662</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0744029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XUH6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013017"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0744029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="164" mass="18336" checksum="E0585F0BC68ACA76" modified="2020-08-12" version="1">MRSDDDWTIMEFSLFLGISNDAQFAPENFKSFCTTYLSNRTPIQRLTRYVNATGKSCSYNSFSGYVSTVAGTTITNDGWTRQWTYQTCSEFWSGQGTATASGVFSPLKYATNKVLVDKVCKSAYGIANVDAKVAATNQRYVDSKSMSKTLSFPARRTIRGLPWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XUW7</accession>
    <name>A0A6G0XUW7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_000841</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XUW7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016839"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="324"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="622"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1049"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="245"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="347"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="402"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="492"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="527"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="544"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="583"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="622"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="656"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="679"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="751"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="788"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="844"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="896"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="955"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="974"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="999"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1079"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1113"/>
            <end position="1125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0744354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1137" mass="125064" checksum="72C1FBCE58DBFBFC" modified="2020-08-12" version="1">MSRTSGQVDIRNAYQPPSTSAASSIPDNATRPATARFDGTTAARVNGSTDTRPARPSSAHTRLLTTYGATGSSPKASDAVITKQDLRRKRGEEYLSERIRQIYGDVGRDTNRPKRNSMMFQDMSGRPYKGESESLQDTIHALKYQLQQESDKRTKLAARCRRLEQVVAMKDKKLEEALAMHAQHSSYNSYQRELANRERTYNHMLGKLREKIDQQTTTIAAYEDIVNDLKAGTKHTRVMEMEESLTQFAMELQMARAKIDTQERQLAQAQKQLEDRSEATAQKTVKRLRSIVLALNEDKKRLDKENKVLKAYIAQKDHELAAAHSAALKSHPKPKVGSPTKRFMPPTSATNSILETTYEASPTPHPPPQKASRPQSAGRARPTAPGRPSTSGFKRTVLSPARSASTPKKATQQGDTKASPAPSTPATEQQPVVAVPPATKEENTHPPQPPQAHVPDTPVETPAPQKSNAAADCPLLHTTTSEEVLDAPESQPNHDVKAHDDRLEGDEWTNDGEAVAASEDDLEETDIERILNRDDEPVRATNDHDDEDGEDDFDELMAFEPSSSVKPTSEEVELEENNMKDDAGDDDNEEAVDEDEADDIATELDEVTAACKIQKIFRMYSHRRDSMELHKETVLRASKSSESEIKLHEENSPAAVEEEEDDVYSEPAESEEGKITPGASQSSLQSSPEPQDSQPEAPSTDDETTRRQDIAASTIQKAYRRSSIAFVVSRENEEDVKVSAEDEENTPRNGLESHDNEAKYDEAASAIQNDFRHASARTSVDSNEEEMAERHDEVETSSADKEVVQDDASEVYSEVAVSEGQITPQASDASIDKQQDAAESPKGFPDDSSFKQFDEFDSQESDVVVVRDEKPSANETAVVDQADVDTGDFVASSQPADEEGTEVESEIPPTEVATTTIETPKDLEQQESLEEATKSFGELALESTSNDDFDDSRVEATSAQTNDINAAILAPTEAAHDTDNHASDDVDAKQTTSNAEVDQLERTQARSEVTKEAEAAVTNGEGAFADDQSEYDVATPRIEVAEKELTIEATMYTPVDAPASNFEDEMPTKEENPPVSPSADDRKLIESVMDHLDIAESDDEARPTPRGEAPMSYEDEFLDDEDDLGDISQDAHTLAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XV04</accession>
    <name>A0A6G0XV04_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_000868</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XV04"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012036"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0744384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="116" mass="13092" checksum="72E8AFCE97A2FF38" modified="2020-08-12" version="1">MKKCIVLVSTQSFSAENKNNTNSLNAILNAKKIKREEVDGSAEENTQRRNDLFAISGVRGTYPQVFFQSEGDDKPQFVGLFETIQEMNEIDDLPAEIIEQNNLKTFSSVFADVERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XW17</accession>
    <name>A0A6G0XW17_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_001120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XW17"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018503"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="485"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0744659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="520" mass="58589" checksum="5C2CE3E32EE0258D" modified="2020-08-12" version="1">MSVSFHDKSCRMSTGSQRHLQGPAGAGSVRRKSSLAVHTAFRHVIWHIARPSTCHRDFHPLRKSLHWPSGLHRRAAALCSFRAKVLKTQRLIEACLTDIQRVDVAAACPHASHASFHSLGTAAFTCVRCGARIDTSSRSHLLVQALDRTKFEYQVSTVRPKLIHVLDQLQMTLEDFRSYQSQWNRDVQLTAVILIQRMCFVFLLRRRAIKVEKRFEESEAAFTRRLRRRTAARGILQLQRRQRRGLTKLPTTSATSEPQSNSEELEGVMETTQQDLPNGVDVVVVVDKVAKTPVRSASSTAVPRLNSTATSTHDVAARESIQSKRSTLESQSDGVVVREPCESKRLFLESQSHDVAMRGAIKLPCLDKPQDLLIYRCFEPRCGGRRFHNKKWFDEHMRKHATAKERLAKERVFLERLERLPRIKPSTVLQPPPAPGGQQLGRSGASPQSLHDEVSTQSIAVAMQLVRLDETHDRRVVLIHKESPIVLGRSAKHCTAVVDSKAYPGIVSKRHACLSIQDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XWA5</accession>
    <name>A0A6G0XWA5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cell morphogenesis protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_000572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000003">
        <property type="protein sequence ID" value="KAF0744988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001826"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025614">
        <property type="entry name" value="Cell_morpho_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039867">
        <property type="entry name" value="Furry/Tao3/Mor2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295">
        <property type="entry name" value="FURRY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295:SF30">
        <property type="entry name" value="PROTEIN FURRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14222">
        <property type="entry name" value="MOR2-PAG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cell morphogenesis protein N-terminal" evidence="1">
        <location>
            <begin position="208"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0744988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1690" mass="189586" checksum="F418585770814156" modified="2020-08-12" version="1">MDDLVAILKRELDEFMATHASTVLAKIEDDAMDSVCLAEVRRIGSMWAVMATRNFGFTVETILQWQSARLDGSVFGRVGLWLTGNVLQTILDRPLPTTPTKAWESLVECAFKVLAEWNQVESCFTTDAPSFFTFKTVKPIKPTNDFLLQEAVHAVWKDNLGLMGRCAIDSIKQHVVDDPERASSGITKETFLNNLSAIRFRLLRPDALFDKQAQATTSFLRVLVSYTHKAQRHSLRLAALQVLGTILSRELNGLSVDGVRAYHDVIHADDWIALVQDFHTSVCKLSENKRFAVVAWQVRLCLLLLSSKEQFSQWWKDDATALMDVFNRQKGSIPFLHLVDLFLCHLVQRHLATGRRLPAATDMMEIINSIQAWCFTNSKHKVKKMRAIFAALSRISQSIATYNMDYAVENHIHHLIVDSESIFQVRQLVGLLSLQRLFQETGLLGAAAAVNLDLDSSALVAHCSTLGAVVGNVLVDCSGHFESSKRPAKTSDNNRWLGLQTFEAAIECTQVLFRHMELHFDQKLLILARCAVHNDGNLRATAAKAIKRIAIALEDTTVIRYLVEFLLRPEQSEAETALMLDELHSILLEPDLPRIQSLDGDLGPAEALALFFLCHNSHRIRQQALHLLECVRNIRKVGLKSPTINAMDVVTGIDGDLQTKFGLQPDEKESALHAGGVFHWLVLQSPPKEWLWSMSLSMLFPRVCEICPSVVDHVWSSAVDLIHQIEPDFHGTDGDDGKDSASQWRNLSILACATGIGERLEATRTLLQRQCKYLASPWLGQRISAVLAVSSTHYSVYMPLLDVLGTFQAEAFDDVSRYKGPHVASLQLALQWALSRCFRALVEHRIQMWSDSQFRQHVLRFVDKVYAALTAPRTSDGATSMMWTWWIRFEFCCIVESIVHQNNMVHLLDEDEMLVVQPSTREKWFLAALQWCSTRPQVFTAKQTTASMLLPCSRVDAQAPWQQYLLTKRAYSAMAMLLIGPPFNLSSCFSWIDACFALPNAVELQAIVASGLRLLVQSEHAAIIPQCVDRCYYHDPAASQVAKQYLDVVASVLVDLIDEFQRSSSLCELIFAALLHLHQRDNHAAIHILTALTDDSAKAAYLVETKTTPRHTQFLLCQIAPKWKERSLDVLQLMISFVAKCSTPHLQAHILSLSPSWAQQLSSMDRSLLTHLFRLTHDNLQLAALNTLWLELSRCHDYRHVRVLVEFFFSLATREKLQTATHVFKWITPSSVDVQQILGEIMRQAQAETTFATSCLAVTFLATLSFHMDDHVGAVASRWAFNILFTTLRDKSTLDEMFATIEEDCMSIIEAMIDRDALGYDSLLGMLRNYLASSSSGPDDDSTGRPTVDEYEAFLESFCLSLTPERQDAWTRTSIASILSAAHDASFCLLSYRLLRPPFDGTFCLQLTARLTAALDDPDAAPMVHEYLLTLTEMAASMPPNKLVLFPRLLWTTVSLLNDRGGSNQVTALCLLHQLVSKPTFQEPIMQDLLAAQSPSSSRDVTLEILVAVCRHLNSLESEPQVVAIVRCLLGSNVETKLHCVMYTAILLPQLVAKRMEPSKTLDARQELSYLWRLQQQHALARCFLDEMQSPWKLAPLAVGKLIMASLASPDEEKMFFDVLLGILNGQCTNLIAPTIELLHGLLQAAAPPLFWKRNAMLLATLTRILRSTDANDTSWPVLVSLLSTLMPCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XWL6</accession>
    <name>A0A6G0XWL6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_000698</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000005">
        <property type="protein sequence ID" value="KAF0744865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XWL6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012077"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058669">
        <property type="entry name" value="TPR_IPO7/11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF70">
        <property type="entry name" value="IMPORTIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25758">
        <property type="entry name" value="TPR_IPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="5">
        <location>
            <begin position="37"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0744865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="977" mass="108476" checksum="A8048523031907DC" modified="2020-08-12" version="1">MATAAALPTALGPSHAPDIVSTMEQAMNTHYETRVAGEATLQQCMKLPGFSLVCLQILDEAQYPLLPAIRLMTALSLKNAVSNSWVTRGSRQYTIAAEEKVQIRARLLAHMDESNNAVATQLAVTTARIARSDFPTEWPDLFAVLRDHIQQERLHRQMRALRVLKSVVKELASRRLMAHRVIFNDLSVAVTPFLASVWKSLITELSGGTQTVIPNLLLCTKVLHHLVLHGFKALMPLDVIPFIFTNYYETFRALTTYIKSLASDEEHLEVLNKIRISCAGLVVAVQKAHPIEFRAYLGPFLQMFHGALNDPSDSPEPLVIHMLTYITNVVGCILYQQSPSTLSTTRVFITATGDVELTDAIVDECKAQIGAFGNDVQLLSSLLELVVVRYMRLKNEDVLQWVEDPEGYSTIQESLSAEDSVRACAEILYLSLLQTHRDMLTPCVLHMIQSTSAWMATPTPVTEDILRADAVLLAAGLSSYDLHESFDFEPWFLQTLVPYLQSPISQTVSGVPVLPRRIVWLIGCWLAQLSNQVRIPLYEALLQLLSAGKSDTCVKLQAVQTLESLVNDWGFDQATFVPFMPSAISCLYAFFADANVTTTETRLKILGCVEAIVHVCGSEIAPCIVQVVNPLPSIWEAAGSSEANLLRGKILSLLTRIMEIEWSGTSDVELQNMVLSVVSYATNPNQPDSIYLMDQGLALWIRLTEVVEVYTPTLHEIFANIVQALSRDTEHIQSGLLLFENYVILGTTSFWTTYGLDVSRLLRSFIGEVKPEISHNICRLLDRILQMIPAESLGSLQESLQALWATTQEQPRQERELVVISFLTTLASSSLHAPPLFFAVIPVDQAAVYLDTLLQLFFSVAFSAVGPAKRRIWVCSMCTFLTLSNAVMERMGLILEAVADVLDEVDPLEVNDEETPTGARRSLLVAQKSKFLPPTIPYIKQYVCAQLNKCAQMVGSDAFNRCMALVEANVLSKIQAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XXH7</accession>
    <name>A0A6G0XXH7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_000440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XXH7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017298"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0745421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="21676" checksum="531CAF71009B2BC0" modified="2020-08-12" version="1">MSPLLSNKSLAAATTTYAFQVACRETKTSWTLRRRYAHFVAVQNKLCQLERASMRLPSVRSLLRPIVEMELTTLDASNPFYDQLQAFAGKLAQIRLECMALATVPQQNDRLLYMMNEIYVLLTAFLQVPPMQVEEELRCVVATASCRSDVVNQMLDLLDTSSPSLLIFELNDIFRLRSKFHHSTPSSLPVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XXX5</accession>
    <name>A0A6G0XXX5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_000441</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XXX5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017297"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051826">
        <property type="entry name" value="E3_ubiquitin-ligase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765">
        <property type="entry name" value="RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PX" evidence="3">
        <location>
            <begin position="22"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="2">
        <location>
            <begin position="179"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0745422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="26221" checksum="5D2559803643BDEA" modified="2020-08-12" version="1">MCLATARRDAVEMKDGGVQVQVSARTVVRLPRRGGSNKTRFTLYTFVIHVAETQTWWIVRKRYSEFRDFQSKLMAMSKHCRGIASLQEHHDIVACVLALPFPSRNLFADTKAVKAARCAALGNITTHLVTLRMQAQALPPVFHTKLLQRHLDTFLDVPNFHRQVELTNIISPIKPQHICTICLETQVHGTIVALHCGHGFHQDCLLDWLSDNCTCPLCRKASLYGVLAPLTQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XYC9</accession>
    <name>A0A6G0XYC9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ae201684_000199</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000001">
        <property type="protein sequence ID" value="KAF0745751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XYC9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019193"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03275">
        <property type="entry name" value="ABC_SMC1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028468">
        <property type="entry name" value="Smc1_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF12">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="13">
        <location>
            <begin position="521"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="658"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="868"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="971"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="176"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="313"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="444"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="680"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="756"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="1040"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="665"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF0745751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1241" mass="142276" checksum="8DB0C13AAA9D04D7" modified="2020-08-12" version="1">MGRILRLEVNNFKSYGGKQEIGPFARFTAVVGPNGAGKSNLMDAISFVLGVQSRQLRSNQLKDLIHRSGSAINAKGGAFVSLVYELDQDEKSRLTSKLRDPSVKHVVFTRSISEKGVGSYRINNQENTYEEYESTLKELGILVKARNFLVFQGDVESIASKSPEQLTRLFEVISSSDELKDEYERCLQEKTVAEENTIFAYQKRKGLAAERKIVKEQKEEAERFNQRRTELGKLKQQYYLWQMHHVEEEAVGHKEAIADGKEKLERLQEKNQDVLSLHKSKKKAHATQLKSCRQLDTAVTEVTCELEDITPRIIRLNEQVKHAKKRLEAAASQESILGNSARDQEREIQGLERDIEDLKQAEQELEETKDDEQLVLQGEQLKEYNRIKEAAQVETAILRNELESLKRLHQADNGRLQALFRDEKEHVDEISRLKEDQASADSRLVDMRRVVDQSTSEMHEAELELQNSEQYERTLMNKKQAIRTELDKIHLQLRNVKDDWRQNQAEQKKAEVLDTLTRLFPGVRGRLVDLCKPIQRKYNMAVTVATGKYMDALVVSDYKTGCECIQYLRDQRLESVQFIPLDKIRVQPPNERFRDLGNNIKLIVDVIDCDPEIQPAVAYAVSDTIVCDTIEDARDVCFRRNEKVKAVTLNGMLISKNGSMTGGKTQKDSARAGRWDEKESAALKQRREELQAELSVLEKESTGAVRRQTLETKIGTLSNRLRHANADIKTTESKLPKIQARLSECQKTVKQLAPEIKKIRNEINAREKSIATLEGNINSVEDEMFKGFSEQFGVTSVREYEENVVKQQQKRLERRRQLDTHMAKVKAQLQYLRSQNFELQWNEAKEKIAKHKASLKSIETEKRELQKKTTQLEEDSVRHNEAAKEGHNALKEIESELKAISKKRESFDREIAAIHKQLAHEETAIDRINDKKQEILKRATMDQVRLPLVGEVLQYSDGEQEDASDIQLSLDSSAETQTASTEESVSLTHQASRRYLDQEIDYSSLEKRRFDGDKDRQDHLSKFEQQIAAMASELERMQPNMKALEKYDEIQARIAKEEEELEKIKANATEACQKFDEVKDARYERFMEAFNHVSECIDETYKNLTKSSKHPLGGTAYLSLENSEEPYLHGMKYNAMPPMKRFREMEQLSGGEKTVAALALLFAIHSYQPSPFFVLDEVDAALDNVNVNKVSTYIQKCGFQCVVISLKDAFYEKADALIGVCKDISSQQSKTITLDLTAYDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W480</accession>
    <name>A0A6G0W480_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_018848</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000361">
        <property type="protein sequence ID" value="KAF0721861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W480"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015433"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050776">
        <property type="entry name" value="Ank_Repeat/CDKN_Inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="138"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="176"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="205"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="6">
        <location>
            <begin position="282"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="289"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0721861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="328" mass="36776" checksum="E1FDBEF8C3030976" modified="2020-08-12" version="1">MDGEGAAATDDDEAVELKSQEGSKSPSLKSPGRIASAWPQGPRIDVDHYEFTKADYAHRVEAVAAMRERFRIKSQPGYDMLPKPKRTVRTIVEQYARSNLYFLPFVKVTLTDAIWDGDLVNVARLLVKRIPPDSRDKNGRLGLSIAIQLRHVAIAKFLIDKHAKVDLQDEGTLFGPLHMSIIMGNKSMTRRLIEGGATVDLRDAEGMTPLHWAAIRGYLEIVGLLLHHGADVNGQDKTGMTALHIACFKGYMDLVEFLLHTGHADIDIEDENGFPPGLYARIEDQGEVLDRIDEYLSQLKKDAERRERRAKRRAERLAKLEAESNSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W523</accession>
    <name>A0A6G0W523_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_018634</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000345">
        <property type="protein sequence ID" value="KAF0722154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W523"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014717"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026205703" evidence="2">
        <location>
            <begin position="19"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0722154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="183" mass="19042" checksum="5F567377B28790D7" modified="2020-08-12" version="1">MPRLAVLAILLTASTCTADIAQAISWHAASRRLVDYTKVWTCVHSTSGFRVPMRIANDTNVECWSNDATDCVWDDNCDAYVASGTSPAAPLECGCMHKQVWGTVGYDDPAHWCSCGKIALGANPTNPDCTPAPSPLPTTTPAPTSAPTTTPAPTTPAPTSTLPATTVLPTTAQPTTTAPKGAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W5I7</accession>
    <name>A0A6G0W5I7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_019183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000461">
        <property type="protein sequence ID" value="KAF0721291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W5I7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007164"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0721291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="466" mass="51519" checksum="AF0FDEB8CD08EA41" modified="2020-08-12" version="1">MFKSNGRLIDEIIFLGKCYRVFGRDWFNHRKQTQRADLDILAREKKVPLPGSQASPNNPNPRTTQNGKRQRVDQDPESPRELVTKGATLGSSDTPLPWTSPNMYQALDDRVVVSTKIVANKTGSDIMVLPAILERPDAPLSVPQDAYVSGTKVHRNKAVRVKTSLNTTLDELAALDAAVAEAQAAFESNCLTAASKTKLNLAQYVEAGEADWIQQDLEDHPIIFRRQLNELALSSPQLLQPLVQLQLLNRWLRASQGASTPFPKLYTDTFGHRFSLTTLSTDFETLVASSKLEQSVCSMHEDTSQITPVEVETILAFTEMILGASAPLIYSSDTAIYSLTAQPVFSIPSRSQSRYLASATVRHILWGSSTLGTALWDALKAILTAAHTAAKPTSSPDDENPTQSLDDVRQIFNRWAVVMNTMEIAEELEALNVEFENQVMLETSTRRLVQGDLTDLWTDFTVSASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W5M9</accession>
    <name>A0A6G0W5M9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ELMO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_018533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000339">
        <property type="protein sequence ID" value="KAF0722317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W5M9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002091"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006816">
        <property type="entry name" value="ELMO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050868">
        <property type="entry name" value="ELMO_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771">
        <property type="entry name" value="ENGULFMENT AND CELL MOTILITY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04727">
        <property type="entry name" value="ELMO_CED12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51335">
        <property type="entry name" value="ELMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELMO" evidence="1">
        <location>
            <begin position="45"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0722317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="274" mass="31216" checksum="D4290D33E2964CE8" modified="2020-08-12" version="1">MGNQSSSLNAARDAAEIGRRPDDDELILLFKLQTKLHTRLVESPYHLGLLERYWNSMHGNHANNNESQAFTRTGRAWRKIGFSTDNPADDIRVTGELGLECLVFFVDNYPGESRMMNRQYGYPFVKAGVAVVRVLMEVFHVIEVDGSRGRFPVRETLYWQLLVSDTSIFQLFAFCFLMFDELYCEFVSSDKSLVHTGCDTSLVVKLADQGKAKLLATLRRAPEHLTDLTDLCMNGQVLKKNDLKLHVHDLRPKATPWKAKPAINYNLFEGLTQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W6Z9</accession>
    <name>A0A6G0W6Z9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-mannosidase B</fullName>
            <ecNumber evidence="3">3.2.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Mannanase B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_018820</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyl hydrolase 2 family. Beta-mannosidase B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.25" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000358">
        <property type="protein sequence ID" value="KAF0721917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W6Z9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016396"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004567">
        <property type="term" value="F:beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000050">
        <property type="entry name" value="Beta-mannosidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054593">
        <property type="entry name" value="Beta-mannosidase-like_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050887">
        <property type="entry name" value="Beta-mannosidase_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041447">
        <property type="entry name" value="Mannosidase_ig"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730:SF1">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22666">
        <property type="entry name" value="Glyco_hydro_2_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17786">
        <property type="entry name" value="Mannosidase_ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026298045" description="Beta-mannosidase B" evidence="9">
        <location>
            <begin position="21"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-mannosidase-like galactose-binding" evidence="12">
        <location>
            <begin position="28"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="10">
        <location>
            <begin position="219"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Mannosidase Ig/CBM-like" evidence="11">
        <location>
            <begin position="701"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0721917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="785" mass="88664" checksum="493B4B9C2BECCBCC" modified="2020-08-12" version="1">MSWRPWIVVLISLCAIVCRASTVSLESWRFYNTDTSPSDLVVDITTTIPGTSHTHLQQANIIPNPLERYNERELQWVAQSTWVYETTFDVTNVVPSRLLLESVDGPASIFVNECPVAETANSFISYSFNISSLIQKGQNSIKIKFEPVLNYTYRKAAEYPYKIHATINPNTWAEPTERAFLRKTGSDSGWDWGPAFLTTGLKGSVHVHFEDDDESCAMRIEEYSVDQIFKDNKVELALNLDIEGQCGTEAVIAQLTIDDDEVVSTPVNTLDHKVVLKHAIANPVLWWPYGYGEPHLYRIKLALIRTSDNATLHSRQGKVGVRQVRLVQTPEAGGGHTFYFEVNGVAVVAKGANHVPLDSFPLAPATGEIKRRHLLESARAANMNMVRVWGGGRYEVDEFYEACDELGLMVWQEFMFACASYPRDAAFLSSVTTEVQAQLRRLKKYSSIVVWGGNNENENMFEQFAANLPQKATFNRDTAIVDYVKLFVDTVQPLVAALDDSRPFLDTSPSNGLLTRTPYTKKWGNTSSTIEGDVHYYNVVDDCTEWQHLPRARFISEFGFQSFPSLRSLLEVSNATDWLTVDAIQEFLAFRQRSPNGTEKMLRQVARHFNIPTKAASTSVADHMAKWLHVTQLTQAVCYDAAISTWRRWGTMGILYWQLNDVWQGPSWSSIEYNGRWKPLHAIAKRAFAPVRPIAYLNNTRVLVSVVNDTPKPTATTVHITLRRLPGGDVIKNVTTVVTKETHIDDVWQKDLSALFKGTDCTRLNCFLDVRTDNGESRELKRPQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W798</accession>
    <name>A0A6G0W798_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_018792</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000355">
        <property type="protein sequence ID" value="KAF0721970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W798"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006073"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0721970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="254" mass="29182" checksum="C1F77458DF845E04" modified="2020-08-12" version="1">MFQLTDKADGKAWERIVYQATHLVVELQILIDHSDFDDDLIRFLCFPHPAWPQLFHKPMALSDIAGLVSTEAATEYLSSEYSKFWPKVPNMRPERKSRSWSYALGSTFAVVAKKKPGSSQVKALARRLFNVYDRTGEFKYDPDTDFDRVTQVLTRINEVAQEFVKNGAKFEPDRRFTLVTVRPKSDPDFPKQWFGGKEYPKTVYQWSGEDDVPFWTDPPDASKLENPPHDEEDQDQSASPSEAGSAYEEEVSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W9M0</accession>
    <name>A0A6G0W9M0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_017274</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000292">
        <property type="protein sequence ID" value="KAF0723893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W9M0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020776"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17731">
        <property type="entry name" value="BRCT_TopBP1_rpt2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059215">
        <property type="entry name" value="BRCT2_TopBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13561">
        <property type="entry name" value="DNA REPLICATION REGULATOR DPB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13561:SF20">
        <property type="entry name" value="DNA TOPOISOMERASE 2-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="67"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="187"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="315"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="442"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="531"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="548"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="570"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0723893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="664" mass="73137" checksum="F07BDA8F8378000E" modified="2020-08-12" version="1">MEEAKKLVDSLGMRWDDNLHDGVTHLVAIVVGSAKYKAAKAAKMKVVKIEWLHACFQNGAAVPTGPFELKPLEGLCICTTGLYVEDRDKVQELCESMGGIYHPDLIFGTTTHLIAEHPEGAKYNTAIAYGIPVVTVDWIVACLDAQELQDEDPYRVKEQDKEEDDAPTYLKLNDQLAQCIGMLEDDSIGCFFDGCIFWVTSGFPPDVMQKIKLLIRFGMGTRYDTYNSSVTHIVADYTGRCQHLKDTNDGVEIVSTNWLIDSALAMTCMQEDSYPPRAQPLPERPPTTTPTKTLTKALINTAQKIIPAAPPLAPQPQSLFGGHMFLLLYTDKLGSTGNAVLRAQIKEAGGRYREINTTDPRILQPNDIARMSHIILGHGCELPDGMLPSLCQAMPHAKLATELWLQCCLQDGIIYPRRKHKLFRCSADAHASSFPPLPLPCFDSMVACISMFVDVERAVLSCLLRLAGATLTLKLSKRNTHLVCRLPEGPKFEKAVEWKLAIVNAKWLITSVSAATLMELPAMVPPSKKRKLEPIDEDLPPAILSSQETKELSQEEPRPEAPPTASLSQEVKESSREEPCEAPPPVSSEEVEGGALTQLDNLLGDMGGNESCSLDYRYEPILPVAVAEAPKTAHVNSQFFADSQAVEPNSEMVHYVDMTQSKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WBD4</accession>
    <name>A0A6G0WBD4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_016765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000266">
        <property type="protein sequence ID" value="KAF0724702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WBD4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002853"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055180">
        <property type="entry name" value="HsdR_RecA-like_helicase_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040980">
        <property type="entry name" value="SWI2_SNF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42927">
        <property type="entry name" value="HELICASE SUPERFAMILY 1 AND 2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42927:SF1">
        <property type="entry name" value="HELICASE SUPERFAMILY 1 AND 2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18766">
        <property type="entry name" value="SWI2_SNF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22679">
        <property type="entry name" value="T1R_D3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="1">
        <location>
            <begin position="7"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="100"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0724702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="677" mass="75639" checksum="9EAAA2BA649E9D61" modified="2020-08-12" version="1">MKRSLEDDLPEGWVSRMSVSKKKPYYIHLATNKTQWHRPGTEKPKNEPLAEVDAALTSAVTRAYRVGGSKRSKQNGLTLFQPWPHQVRAVCKVVAAISSQDGSTKTSNFLIQHSTGSGKSYTIACLAYQLLYTKDRTGAGFHTIIILVDRIKLDEQLGDTVESFLHQNGVDTIFRADSIEHLGTVVATPVDQKVIVTTTQKLGLLVQNQVLLARLMAKPTNGNNKTHIAIIADEVHRSHTTATRDSISIILDAMTRQTFYIGFSATPSFHTLRLFGTISDGSYCPFDCHSITQAVDAGHIVNVIDNYTSLRCTYSIKTTSTAITAQLAASPWLLMELASCHEALLSAKATSMMSHFVKLKASHVFAKCMVVARNRRDVVTYHKLVSSFMKRQALPGRVYCTFSAFDAVNEKQFNKCTLEQADVIVVCDKLDTGFNEPALMAMYLDRPLISFGRVVQLLSRLNRSRENKTFAQVVDYVNHPAHIRRAFQDFARETSLSVRDDDLTELDQDLSTSSIVLWDLLPGVIFNDKQQAVEAMGDVSASDVAMKICQLDKDTYMQMKQALAVYLNAATVLRRDSPFLPRRWVEELKRLVVDDVNLKSHDETCEETCACVSARAEMKLQKIKFETAFQGSLGGDTKYDLLSRILNGEGRTKQDTNPDPKDHLDKKLNSLLSQLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WBG0</accession>
    <name>A0A6G0WBG0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_017551</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000301">
        <property type="protein sequence ID" value="KAF0723584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WBG0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003059"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="258"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="394"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0723584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="431" mass="48593" checksum="44B48A6ABCC24B78" modified="2020-08-12" version="1">MKRQASLPLPAGFFRSPSLAQHQERQLIRSGLQSLTDVIRDSRLDGAIPWTLQSQTKSLRVYSSTPNAMTATHTIFMFTAELRATLDEVYAIMRFQEHADFQRYCTTAAAKDIIDCASLYNLALPTPNHPRNYVGVKWIAAASANPLGKKRDACYVEFQDDFEVDGHRGWARALTSVEVDACPNLQLSHGLVRMDILRAGFVFTEMETSGFIHVANMYHVDFGTHMPPWMIDMTIRKRAKIIDGIELMLEQQRPQPMQSPRAACGICSRKFGMLVKRYHCRRCAISLCKNCKHTSRQDRTNICSRCFLETSTAGNYLPKQEESFVETTSTVYCYTSRRESDSMIRQDRSGSAVFDSNGRCVGGDDMPPFQMSVRGGIKLLDSPTEKLLVSRRHRPPCVASDKESHLAAPTVWDRSPPRPHATTVVSLSDRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WBS4</accession>
    <name>A0A6G0WBS4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_016659</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000265">
        <property type="protein sequence ID" value="KAF0724728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WBS4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010566"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000002">
        <property type="entry name" value="Transmembrane protease serine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF98">
        <property type="entry name" value="FI18310P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026179459" description="Peptidase S1 domain-containing protein" evidence="8">
        <location>
            <begin position="20"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="9">
        <location>
            <begin position="39"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="262"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="268"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0724728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="302" mass="33093" checksum="0C12EB89A4267973" modified="2020-08-12" version="1">MRIWLWLLIAIVILEEIQAESDPDRPRRRFRNKKGKNRIVGGVKAKVGEHRYMAGLKGSVNEETECGSTLIAPKLLLTAAHCVLDNIKVAAIGTHFNTGHEGGEHIKIAQKIPHPKYNGEPADGYDVAVMRLATASKITPGKLSFDPVPVGTPLTVRGWGLTTDGGDASKHMLEVQVHAVSDQQCQKNLERKKWPKSSFCAGGVKGKDSCQGDSGGPLVVKKGKDDFVVGVVSWGDGCGEANKPGVYVRLSDPEMRNFVQKYLKSKTDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDYAGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WE13</accession>
    <name>A0A6G0WE13_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_016033</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000241">
        <property type="protein sequence ID" value="KAF0725470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WE13"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002567"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF98">
        <property type="entry name" value="FI18310P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026356425" description="Peptidase S1 domain-containing protein" evidence="5">
        <location>
            <begin position="23"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="6">
        <location>
            <begin position="11"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0725470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="242" mass="26099" checksum="8C1EE0B81711F53F" modified="2020-08-12" version="1">MKVVLHVLLLLVAALVVVFTAAEPQAPSYLAMIQSQGIISCTGVLIAPQYVVTVVPCTTAMTPMRVALPNELLNVTRFSVHPLSNLSRTEFSLAVLQLGQSSANRPATLSFDVLAPQTRAIVRGFGSLNATTPSNATSAVQEKDGLIHANSECAAWDNTLVLDDMVCLSDVYPCGRGNRGSAVTVVQNSQEVVVALLSWSWVPCNRSYTVFERISTAKTYLEPYLPSKNACAMAFQRPQLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WE57</accession>
    <name>A0A6G0WE57_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BED-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_015977</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000237">
        <property type="protein sequence ID" value="KAF0725644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WE57"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021288"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40866">
        <property type="entry name" value="BED-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40866:SF1">
        <property type="entry name" value="BED-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0725644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="18737" checksum="FFA891DEBF7CA3E5" modified="2020-08-12" version="1">MKQLTLVPVSTPEAFTPKEIAAFFFKHGGESTIRDPKTKRIRTMVTYNCMRCVPSTVVTIKKNTGYQNLAQHVYTFHKDHLSQMRQAHGPGKVTSIGHAVSDKALNVFGCLDWIVHNNLPFSFFESARTKQYSDLDGIGATTVRKYLQLVTQQVESEVSSILPTKFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WEA3</accession>
    <name>A0A6G0WEA3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_015901</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000235">
        <property type="protein sequence ID" value="KAF0725683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WEA3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015637"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0725683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="32949" checksum="0F506D33F466A861" modified="2020-08-12" version="1">MDIFARLAEETSQERDNLCRASLVVSASVQESEEADDNSHHGHYDTPTIDNIAAQGPQAMMTMTNFSMSEFNSLWGLCEADVNASWYEGRGRRNQTSAKDAFFMLLTVLKHYNTWDKYAADFNLRVPTFERMMHRMIKITEPVLVSLLIPPVFMSAQRRRSFLFDNFPQALYATDVKFQPANRPHLSYLDAKHYYSYKHKLYGFKLEGSVAQAGRYVNVCDHSPGSVSDLTIFLKRIDILHGVIEEIRVLRRRFQIMAKALRIFLTRGWYCKTRDTKVLTKPPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WEC0</accession>
    <name>A0A6G0WEC0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_015828</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000232">
        <property type="protein sequence ID" value="KAF0725866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WEC0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006496"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000289">
        <property type="entry name" value="ABC transporter G family member 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="496"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="536"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="575"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="605"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="127"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0725866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="652" mass="72416" checksum="A5E908DD2567E11F" modified="2020-08-12" version="1">MRALATNQYSNSEFKVCNYRDVEYCATNGGKKMGTIQLEQFGMPTGREWIWYAVIYMVALYFLFVGMSIIGLERIRYDNVHGALSEEQLMDEEEEKEAYKKMPATPVGSQASDAVIVPVQEFVPVTLVFKDLHYFVPNPTKGEPELELLKGVSGYALPGTVTALMGSSGAGKTTLMDVIAGRKTGGKIVGDILLNGYKATDLAIRRCTGYCEQMDIHCESATFREALVFSSMLRQSSDIPTATKLVHAEECLRLLEMHTIADSIIRGSSVEQMKRLTIGVELAAAPSVLFLDEPTSGLDARSAKIIMTGIRKIASTGRTVVCTIHQPSKEVFEMFDNLLLLKRGGYTVYFGELGRKSAHLMEYFMRIPGTPSMALGYNPATWMLEVIGAGVETKVTNTTDYVEVFEQSEEYKQLQAGLAIHTLPRADVPEMNFSTKRAASNVVQFQYVLLRYFRMYWRTPTYNLTRVMLSVFLAVLFGLIFLSVDYTTYSGVVGGSGMVFMTTLFVGTISFNSVVPLSVEERASYYRERASQTYNALWYFLAGTIVEIPYVLVTTLIFTVIFYPFVGFSGSVGDVIIYFLLLSLYSLMNVYMGQLAAYALPSVDVAMSIGALVNSIFILFMGFNPPHVCHPQGLQVACDDHPTKVQFVRLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WF31</accession>
    <name>A0A6G0WF31_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_015735</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000231">
        <property type="protein sequence ID" value="KAF0725884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WF31"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005891"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF214">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="14"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0725884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="270" mass="31067" checksum="A7BEA267438FAE47" modified="2020-08-12" version="1">MTQLSTIRLDVKQIRFEKKLGFGAFANVWLGFCQDEMVAIKKLHSYRRSVDQLKAFVDEINLMASFNSPYIVKLIGAAWTRPVDIHCVMEFMDSGDLKNYLEIHKSIRLVYLHSMDIIHRDIKSRNVLLDSIKGTKLTDFGISKEDMQATMTVGVGTFRWMAPKVLQDKYYTVAADIYSLGVIMSELDTQRLPYHEIRNPMNGQPLSDHALIGKVIAGEVEPSFTTDCPRWFLDMARQCLHHNADERPTAMQISHILRHVLNRYKRSGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WFE6</accession>
    <name>A0A6G0WFE6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_016338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000250">
        <property type="protein sequence ID" value="KAF0725106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WFE6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020270"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0725106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="274" mass="29919" checksum="72BB616D6EEF867C" modified="2020-08-12" version="1">MFGVQAERILTTCRHAATGNSTPCVNDTIQGKTIDLPFTTGWTEGYFTYDFSHLELTSIETWPSMPTFLDFSSNNLTNLQVAASDFPHFDDYVGIIDLRGNPNIVLTVDSGVYSRLNNDKFYLAMDEPSNSTAALKACRGDQSFVRPIQTFVLHYESDGQSYGHDLDWKLVDICCLGCSTPYTLAHTFPTQMVPAITSTVAPTAAPTIASTPALAIGTKVDSGSKTTVTVVVVVASIAVVAFLVYFAKKTIDKRRRTQNATPKTTDQAAYVEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WFJ8</accession>
    <name>A0A6G0WFJ8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_016057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000241">
        <property type="protein sequence ID" value="KAF0725494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WFJ8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018491"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF444">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="244"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0725494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="380" mass="43102" checksum="20B03DB7EBE8917D" modified="2020-08-12" version="1">MLYDSVAITARNTARNQVMFQEHEGFGISRDGITKIYASHDAKRRRRRMARAAAWSQALAEETVLPARVADTAVLLTAEELILSHCDLEELPRIGEEIVKLPEMSFREFKRAIRSGDIVSIALIQPVDELELNTSSTLDTEVASGKTALSSYMKTWEALRTNPYYDHLREYEDVFPEEVPENLPKDKGVRHEIDLVPGTKWCVTRQWPLPREQVDHIDAFFEKRRKAGHVRPSTSPHSSPTFCVKKPTGGWRIVHAFNKLNSATIPAQTPIPRKDVIIDGMAGSTIFSTIDLRDGFYQTLMRVCDIPKTAVSTPSGMLWEWLVMPQGLSNAPATFNRLVTGKLRPLRDLRRHTLMTFTCTVRSRRLARISRFTVDTSKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WFV0</accession>
    <name>A0A6G0WFV0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calmodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_016122</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000243">
        <property type="protein sequence ID" value="KAF0725350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WFV0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010160"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000527">
        <property type="entry name" value="Calmodulin-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="6"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="42"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="118"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0725350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="149" mass="16998" checksum="A3A9F39AEC8837F2" modified="2020-08-12" version="1">MILSQEEIDACRESFVHFDKDGSGTIDKYELGKVLEAMGQKPSEEELFQMISEVDEDHSGEIEFPEFLRVIEQQKLRAMEYDDESDFIDAFVACGGGPDKQGHVERRVLVQLIKKDFGLPIDIDQMLDRLDTDGSGEIEYDEFKALLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WFW7</accession>
    <name>A0A6G0WFW7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_016034</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000241">
        <property type="protein sequence ID" value="KAF0725471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WFW7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002566"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF98">
        <property type="entry name" value="FI18310P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026149388" description="Peptidase S1 domain-containing protein" evidence="5">
        <location>
            <begin position="22"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="6">
        <location>
            <begin position="20"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0725471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="256" mass="27517" checksum="8488E4866917658F" modified="2020-08-12" version="1">MGMTRLTLLSVAAIAATLAVAANDDGSSSAPSYLVSLQLGNYTKLTGVLIAPRYVLTSAHGGIKANWASIGPANSRDNEQIAVKSMYFHPQFNNYTLEFDVAIMELDRPSTHTPATLSFDAVAPNTPTTVRGFGDFEGVESKSSTTKVYSTHGTVMSSVHCAAIDNIALYPDMMCIVGAHLCGSGNTGSPLTVVRDGREVVVGLASWYFQKCNREFTVYTRLITAKSFLDPYLPMLDGCATSAFVRPQLRFALPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WHA9</accession>
    <name>A0A6G0WHA9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_015199</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000213">
        <property type="protein sequence ID" value="KAF0726575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WHA9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020947"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="699"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="590"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0726575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="794" mass="89496" checksum="30FFFD429A8333B5" modified="2020-08-12" version="1">MVSSKGQPSVAATEADVKVDVDEEDAKKEIAAAEAIDDDEDESDDDNEEDTGLTENQNRLLYLISLYTKPAVLSTDKEEWIRKPALLVLLYEAIVSQAVDYDYAPASELVETKRKYFNISQEGKSDLDFLREEELVNGLKLSSKTYQPVTCYQISEKGQELITKLSKKDKTPIHDMAYAPGTRNLLHVEWDGQEYWLVDSQSGYRRISAVTETETVSYVSSAYVPQCLRRGGRPTLSNAHRAHECGLSDSTIKDELDEIITLNSVSIIVSEFIPFGANQVVQLNCNLGSTERVQGGFFTAVVDTQSTGTQIAVDPGLTSINILDYSLTNHVNFEADIHYPEAPGVVQVETFGCSLTASGACFYGMQVEAIMDRIKDNISLDHLSRLLVDVQRDSSQIVDSVLSSYQRSLLSLVFLNERSNRDKINLIIANEITPHLTAEEYMDKGEYENELKQVIGDTRAAFDISEHDTLVFGSYGLLIAGPNSRHHEPLLCSFLEYESMNLFTQNFFARMFILVDDMKTVRTMVDVAERDPNCLADIRRRLAVLSQQVILMEETLGFLRESLDEAEIPPEPPEQAGRALYERLQLGSLSAQLKRRVKDLEKKMDGARHELAVLNELSAIFSEERIFKQHEAIRYQTRSLCELQTINERSATTLQLIQIVLSGSLAFEILHQLTGDWSLMNESWAKSFLNALVLNAPGLWFFLSLLFWAIVAGVLLFLFKRFMYRAQGVVTIRMTRQVPIDIKNLATFLRSKTISDESHVYDGNVKIAKVVWNEQFKKEWGGTVPTVQVCLPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WHM1</accession>
    <name>A0A6G0WHM1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_015079</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000210">
        <property type="protein sequence ID" value="KAF0726679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012000"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007009">
        <property type="term" value="P:plasma membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd04037">
        <property type="entry name" value="C2E_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037724">
        <property type="entry name" value="C2E_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012968">
        <property type="entry name" value="FerIin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037721">
        <property type="entry name" value="Ferlin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12546">
        <property type="entry name" value="FER-1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12546:SF33">
        <property type="entry name" value="SPERM VESICLE FUSION PROTEIN FER-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM01202">
        <property type="entry name" value="FerI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1735"/>
            <end position="1755"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1775"/>
            <end position="1794"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="162"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="373"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="539"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="881"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="1040"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="1279"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="1438"/>
            <end position="1569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="338"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1577"/>
            <end position="1637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1584"/>
            <end position="1593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1611"/>
            <end position="1622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0726679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1804" mass="200888" checksum="4C0CD246120BB252" modified="2020-08-12" version="1">MPLLRVKVVAANKLLAVDSNLLGGGPSSDPYVRLTCGTETCKTKEVKKSTNPQWHEEFRFGEACLLDLTTTTLHFRVKDHNTLGPAEDLGEVTVQLDSLTHGQWNKLTLPLETHASMNKKATGDLIVEIYVDPTQGVGAVEAAPTAEATVEGDGTDGSGAADGTEPSPAPSSTSAWTFNVLAVSILEGKGLKAMDNNGGVFSSDPFVVLSIGDSGKTLKTNVIKRSLSPKWRQKFFFTIDPSTKYANTVLKLRCEDQDIFGSDVMGLLAIDVREWIQKFGGVKKDLWLSLGPDSKNPTRANLDEEEPTELGFGQLHIAIEPCTLDYTVDRLAQGETDSEVYDAGDGGESGANGTVEDTPENVKETDEERAKREAEQKKMMDELQQVDFKSGDYQIQVRIIEVRDLVPQDANGSADPVVFVECMGEMQHTSVKPNQLSCVFDHLMFFNFKHLDKDDVESASIEVTVKDADGPFGAADKIGFFRIDVPYIYYQKNHEMYRQWVALVKSAGDSEQGVQGYLLLSVAVLGPGDKIQIHDDKDIQQENEMVLMPPRLAQSLYFLVVTVHRAEGLPNMDKTMINQGGIDAYVKVQFAGEKPLTTRTVSTKGSDVEFQQELWFPVLLPCMSNLIKISVWDWDRATEDKLVSFCKPYYFNQVKDHPSLFKHIWSNLYGAPEDSRLLQFNQKSKDDMNMHPDTASTFRGRVLMSLRVESNVKNTLEIPHTRNLLSTMPVPPTQKFALRAFILTGSEIPAFASKLNFGKNSKMSVRVCCGTTTLWTTRVENNKGMCHWNQYMEVEKILPSDLSQAPDIFVYLVTGAVGPVASNICFARYKAASLVHNSGELPPIKWVSLMEDDVLNNLNDDQYTGNLLLRLALEPAESASLTEAAWKDLPNNKSPSASYALMVHLFQGRGLPAADANGMIDPYVAITCNGVGLKSSTKMKTRDPMYYETLVFDIEVPTERAHQPRIGFQVFDWDRWDKDDFVGGVSIHLQSLDIISSADYNAGYTVPKPKWYKLSYEEDRGGFDDGELLISCMLVAKDFPDQVIEPPASIKPKMQEKFLEIVCLGVRDLSPIGFMPLHMPYLQFDIGEVSSTNRPKKTAGSSKPSPNNPNFLERIIIPLQLPDDAQFAPRLNLGVYDTLLGGFHKPLLGSTSIDLSTKLQFSNGLPNPNYVAPGEMTKFTTGNPHVDGPVTPKAVGDDGKGLPLSMKNENAVPELGPEDDEIPPYLRNRNIMTVSVEEKLQTTPFEVYFVYRGQKFGGAESTYRPVGKFKGLIRVINSRDEPPLFDLQELLNPQPYVIRLYVLDAFSLQAKDQNGKSDPYLRLKLGNHTIFNDRDKYIEATLNPKFHNVYEFKANLPGASALSIECFDFDLFALSADAGDDFIGATTIDLEDRWFDDRWRTMGNLSEGTFRPVETRQLYTPASVVTQGSLRLWLDILTPTEASMSHPVDISLPPIEQFEVRIVIYKAKDVVPGDEFSEMSDLFVKCWMQSYAERAQYTDIHWRAKNGKASFNWRMKFDISLPIDPQNELDKGHLHVQLWDKDMLFDDCLSDTIVNLTEPLKQAYKTKQLVNVYAKQKPVKSKVRTPTNAQLNQPARGKNADDIDLEAGENSALLTRSTSTASQNKRKPKKDDKKESANMMIKALKSRIGMGDDPEDAQWLTCTTMDPHTKTRVEAGKLLMAIEIMPKAHAEVRAAGMGRSEPNAFPTLAEPADRLHLSALFNPFALLESLIGPKAFGACATFFYCAIIVAILVFAGPLVNVLLTLMNMLPHPFGWIVFGVLIFVFVGGFCYCSYRCRSALSSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WI35</accession>
    <name>A0A6G0WI35_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_015005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000205">
        <property type="protein sequence ID" value="KAF0726863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WI35"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019180"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="15"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0726863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="353" mass="40909" checksum="EA4DDA15CF7AF07A" modified="2020-08-12" version="1">MSELALQDRCSSDMKEHLELATKELIEAVKSLEQDLVRRKKHADPHFVALVIAKSKIAAFEEQNKELKTMLADRELLKAWLADWVDTFTPRQGEPNYMELTLLQDDEGRRKGSIYMTNQIHIMSQKAYPYKPFGNSLEDKTGVKIHSGEDEHGVCIKAYENYVHFTVEGNYENVAKTWRFDYTESTTLYTVLMVEKMDEDILYSIQEHNELKLKRISVSGVFPGYPGQDRITITHAGIAVDERFPFGDGETRVNGFQWTIFEHITDRLTLVRWSLLVFPPVNAQGQLSLHETARSLRCPVNRFDSEEAIIERIRNIGELGLNKLRDQFRERCKRFVLEAPTMGSRDQLFEEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WI59</accession>
    <name>A0A6G0WI59_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_015011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000205">
        <property type="protein sequence ID" value="KAF0726869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WI59"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018216"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47718">
        <property type="entry name" value="OS01G0519700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47718:SF3">
        <property type="entry name" value="PROTEIN FAR1-RELATED SEQUENCE 5-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MULE transposase" evidence="1">
        <location>
            <begin position="278"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0726869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="452" mass="52129" checksum="3E658B03D9ED058B" modified="2020-08-12" version="1">MNVMILLLLLQDKRGPHNLKYMQQTIPTTLPTSLPDSNTRTTPVPPFHQFPVHPEAIFDSPEEAQATINLFTRDHGYAVIRLRRVLDKNSNIRRVVLACDRHGVYKPSKSTPGTKKRNGKATKKCDCPMRMHLVREVSTSSSTCAWRIEYRGGESHHNHEPSMDPSSHTMHRRFDRTDEVIEAIVTDANTSITAAQTLVQVRQNNPQILLRKSDIYNAKRKETLKRIGCNTRTQHLLNELQKNGDYYRHRLDMESRLSHLFFAIHEVLDVFKANYDIIMMDCTYKTNKFGMPLLNFIGVSGMNTTLHLAHCFMAGESTDDYTWALTTLKECLSSHAILSPSVILVDRDLALLNALDTSFPNVPALLCLWHVVKAVETHARRTFQKVPDISRTNSNDTNLVDSPQHRKFCDTFISMIRATTEESYNQYHAQLWEMSREEAQYIDETWLFMWKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJA7</accession>
    <name>A0A6G0WJA7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_014557</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000198">
        <property type="protein sequence ID" value="KAF0727296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJA7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010185"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="6">
        <location>
            <begin position="19"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0727296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="324" mass="35476" checksum="75A640BA5E56F7CD" modified="2020-08-12" version="1">MPTTRHRSSSWSSDNPYQAVIYMVCWYTFSTSATFINKILIKEHGLSAELLTVCHLILGTCFDAAIFAVPAKSPYKMWYLHPMKSGAILNLLPLSVLAIASKLLTYWSYSKVPVALTHTCKASTPFFNVILAFLIYRTTHAMPIYLSLVPIVVGVSMASMSEVEINAFASVGLICAVSSTMFGVMQSMYAKYLLRNGLVADSINLHFYNGILCIVVNSAVFLVNRSDTVPILPEKIPYGLILVCSTCQFVSSFSSMLLLGKVSELTYSIMSTMKRVVIIVSAIVYFGNVMTFSSGLGMALALSGVGAYQYVKLQAPPATEKHVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WK51</accession>
    <name>A0A6G0WK51_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_014462</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000193">
        <property type="protein sequence ID" value="KAF0727637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WK51"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020688"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007255">
        <property type="entry name" value="COG8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21311">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21311:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04124">
        <property type="entry name" value="Dor1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0727637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="530" mass="59287" checksum="07BF92427E6EB3B7" modified="2020-08-12" version="1">MMQEDVGQPWRLERRIDDVSEKLRVLALKNYHVFVQSQQCSQVVASDLKSLGGNVQIVDTRLPELQSQCKQLDSAVHASASKNSEIQYILGHYDELMDLLEIPQLIEACIANDLLEEALESIQFAKKIFDQTDSSKGSPANTILHTLVKEVHAATDVLRQKIVEKLRGDLSLAKCLHMVAYLRRVDGLWKLLPVDYNQQLKVEFLSCRDSWLSKTMQSIPTSDPYNFLMQLIDAKRSSWFDMVTQYSAIFGHQEMDGHVDQPLCAWAIRTVSELTQILSETLPKLADFGAVANVMEQVLFFGGSLGRVGVDFRGIVFVQFQKHLVETLSTQWRDVVDEFDVALGAYSSKQSTTPIMLASFRNLTTTTDGTSHGRISSHAHRLLADTSPPHVIMAFPVLAQLTNGLLNSFNNLRLCALVSLEYRLSQLLQSAMVGVIDVLARFCQQHGITPKEADVSSDGLMKKAPIGVQIHKLAMVLQTDWIPFIHACFLKLFTRHKGLPTALDMDALVALLRAKRLVLEANETTQVDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WKG9</accession>
    <name>A0A6G0WKG9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_014281</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000189">
        <property type="protein sequence ID" value="KAF0727767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WKG9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020626"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0727767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="291" mass="33673" checksum="24B8FE4B75A54D41" modified="2020-08-12" version="1">MDETTTGYQAYKEKYNETVAAPNAPLLRVIRPPDDKETESKRTELIGTAEELLEHDMDELKEATHVHNLEIQKHFDAIMERARHFEAKLHDEEVERDASIGALRLHVTQAFDSAYECMETKAIEAFHVRLEDTIPKQETRASDFSAAFDEFVNVTVPGIIEALQGTITRRLEKSHETFDIDNSKLLKREKKMRGHIETHERRTAQAFTDEKDRRVTTFVALEEAIHTTMQLDDRHAERKQGSMIETIVALRAQYDDERLVREKEDAALLERVAETMERLHVSILESFGEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WL98</accession>
    <name>A0A6G0WL98_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_014054</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000183">
        <property type="protein sequence ID" value="KAF0728047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WL98"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018055"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0728047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="177" mass="20019" checksum="EFDEC5B37F0C0491" modified="2020-08-12" version="1">MELFTIDAAGNASLRDPDLCFAKIGGHKPTLIAEVEERHRSVLSLDQWWRGYFHTPGVRLVLGFKLYPANLNGDVAALVLQYGYTSGNQVEIMDAVSFGMRDVEPQGIPHDIWSRIRFLPHPTRAQMESCLDPWTPDDHGFLTLPRAECLYGAPDDVLNSPAEDFRLPLFRILFDYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WM69</accession>
    <name>A0A6G0WM69_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anaphase-promoting complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_013758</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000178">
        <property type="protein sequence ID" value="KAF0728394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WM69"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002379"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037679">
        <property type="entry name" value="Apc5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026000">
        <property type="entry name" value="Apc5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12830">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12830:SF9">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12862">
        <property type="entry name" value="ANAPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 5" evidence="7">
        <location>
            <begin position="195"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0728394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="709" mass="79688" checksum="0D422D0B528256A7" modified="2020-08-12" version="1">MGVLDQSNSTHLLVELSPPNVCLGFLITKYVRVYEESAGLVVETTALSTVNPLHKLSTFLMEQIPQARSSPLSYKQYTAALDTIHPEWRQDLDLTMQRMCERSVDELGECLETMCLPSPDQLLASTPFGRFIRMLSLAVRGAFFDGLCSFQQVLRTYISSTDQTTAIRSSAVDGMARDAPNFNPPSTSPSVLFERYLVLQQKREFLGALDALHTYHNYAIHVQTEDTPDMKRFGPQYASLNVAILYWSFQYREEAMLALEEAIRVAQRARGMVCVAYALSYLLQWELFDAKRAQQCLDMAGDVPILSLLATLSSVEHMHTMKSTGLPKSLELWLALKNALHVPKISGSKVSLEELRQEWQTRQTKLALATAAVWHRSGHRLLEQLYVQQATAATANPSIDDLTTATCHSAGLTIQPTELPKDNESIYATALRNMVQAAETHPKLVHQPLFQQMLLSILFEWALAKCQFRRAHAYLHQWESLLAGALMNQRIESILARVRLYMRQEDFSEAKSLLLSLNTDKIPPYTRARILFHTAQVNMHDDAPFDALPALLECLALCEETQCDAVLPEAKLHLVKLYTAMDQTQDAIALLKVEFPHVVEHASLQLQAQYGLVLAEAYVLNQAWSDAVELLQQSQAAAMAVEDLKLTLNIGHLLVRVHHLQGDLDGREREAKKCLSWAKDMQKNESIGIEDAFVLTEPSSILDLVACRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WMF1</accession>
    <name>A0A6G0WMF1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_013703</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000176">
        <property type="protein sequence ID" value="KAF0728519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WMF1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010033"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="entry name" value="Sodium:dicarboxylate symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42865">
        <property type="entry name" value="PROTON/GLUTAMATE-ASPARTATE SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42865:SF7">
        <property type="entry name" value="PROTON_GLUTAMATE-ASPARTATE SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00173">
        <property type="entry name" value="EDTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="Proton glutamate symport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0769">Symport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="479"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0728519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="568" mass="61892" checksum="3DD99329C22A1271" modified="2020-08-12" version="1">MNPSRPKIVLFSGDFATESPEQNIQTAYTELPNESKTNKKVEAYDEAREAFPQHHLQKPSFMKPKSFELYGTPRSKPGPNPLQRQQKMLVLGALLGIAIAAILANWTKLSPDNHIDQNAAKWISLIGVLYLRCVFCIVIPYVLTSIAVCIGDILSGGKGARITVRVFGYFFLTKILAVCTALAMALAFRSKFAGPVNVKPTAPPTSIVLTCGYKNSGFMSMADDGTLSCKETDPQGDDSINFIVKDRNNAFVQVVDPHPIPQVAYVQAVIQLINTGVPENIVTSLLSKNIFSVAMFAILFGAAVNKSYHQHSLGSTLMLSTLRQFNCMCEIIMRWLLHLSPIGVCFMIVGAAASGEPVVSITFVRQAFFFILAYLLSVAIYSGAMLPALFYITTKSNPYKYLMAMVPAQIFAFGCSSSAATIPITIRCIESTREVSGSLNRFVVTLGAALNKDGTAMYLPLAFVFLLSMKSDANLDAGHCVALVFLSIVASVVTLPLPNSAPLTLFSIWSTLQQPDKFPADVLVLTSINWLVNRLTTAIDVTGNAVVARIIADQVEEHYDSEHDQSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WMJ0</accession>
    <name>A0A6G0WMJ0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_013709</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000176">
        <property type="protein sequence ID" value="KAF0728525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WMJ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010026"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0229">DNA integration</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="12">
        <location>
            <begin position="57"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0728525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="582" mass="65619" checksum="1B86F317F208B3BC" modified="2020-08-12" version="1">MAVALGHLNKPVIIKLAQDSLPEEMIVTGVEHDLKTPCLECAVGKQSRSKQPKQDTSESAPTEEIGSAIVSDVAGKITPSHRYTNKYFVNYVDHASGFVMTYPMKRKSEQAAKAMQFLAEFETAFDVHVKVFRSDRGGEYLSDKFKQFLAKRGIRHQLTERATSASNGKAERMHRTLLNATRTMLFGCDLPPKFWSHALEYATYLRNRTPSKANAEMKSPLAILTDKQPSLAHAVPFGSTCTVRIEPRTKGIERRAEVGRILGVNVQTKSYNVWVARLGKVIVSTDITNIGKPRKRVLSDEENATLMEIDQGVIDGETTKRAEEAKKIRKRDQDRRLEIVQKDHERIAPEPRRSDRIHAMQLSKGGYMALVVTYVDPKTPKEALDGPNADKWREAMQLEVDNLIGNGTWELVDRPKDINIVSNKWVFNIKYDSAGEIEKFKARLVARGFLQRYGVDYTETFSPVIQQQSVRLLLMLGLHFDVDVAHVDVPQAYVKAGLDTNIYMAIPDMVPGDPETQALRLLKSLYGLKQSGRMWHADIDATLVQLGLQKSKPDPCVYYHWTEEGITLIGLYVDDIMTMSQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WMK6</accession>
    <name>A0A6G0WMK6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BED-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_013537</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000175">
        <property type="protein sequence ID" value="KAF0728574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WMK6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010945"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0728574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="601" mass="67111" checksum="7FDEC086145BC005" modified="2020-08-12" version="1">MSAAGRKTKAGRPSHAVWAHFIRGGKRNRFHHHVYCRYCSQAQAQALTSDAAGPQSIEALRGVPETMLRHLSTCVYCPANVRLEMKLMMAQHRTMQQRKSRSTTSNPPLLDDLLLLEESDKATNQDSNHSRPGIDDSAPDSLSFAQITWGANVPYSCLWDENVRMLLPFKSLPSPDTVYSLTCSQNLQEMDEMSGLWTLSVNTWTSVSTREFFIACSIIQPSSSSSQTISITSVDKKVHAVTAHLIEVLASIKVQLVGVVCDSAMSLESARAAITSLELSLTSSLCIRYMLRLIAARVFLKYKDIVRDVLFSPLATVSDKTMPSLASWSTWIACVLRSKVVHPIADVCAALQDAYAALDNSDHTPLTTFDVVLLLAKLSSLDETSEMVDTLWATCDIPWMLLSKALYISSSPPKTSQVPALQWISLASYAHTFARQWQLNETQLTNDLVAFKEQKFPFDMVAGYANNVQAFYSFVSDSTPTFHSFCARLYGYVPQTIGLEAYIPGLNMAGLNPLMARTDIPVESMLTLVRFQLQQGRHVTPKRTYFPLDDPTTVWDADEWDSITEDLEIFIKDEMEHLHAIQQAPIVSLVELRECWRTNAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WMX0</accession>
    <name>A0A6G0WMX0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_013621</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000175">
        <property type="protein sequence ID" value="KAF0728663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WMX0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003204"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="106"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0728663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="521" mass="59611" checksum="639479A2E727C61D" modified="2020-08-12" version="1">MTEWNMKFLTDSSFDEENKDDEETKNDMQPVDDGSDDEWSEYVEHGWKKHGNYDTTEDIEGLEDVEWTCGGHYAGPTHLYEREDNKDDTPVDELRISDEFKDLFKDPVKGFLAFMPLEFWKTVTLRTNAKALALQAAHPKGYVGGREFKKSFELVEVMKFIGLLIMMSVVQGGEYSLYWSKPNRFKQLRACITFNDVVEPADPLWRIRPHINLLKAPFKNFVVAGREISVDEACIPCRSSYPRALIVYNPKKPLGKYHFRIYTAACATTWYVFAFKIHSKAAGNFDAGADDDADDDGEPAPDDDTAKPRDEVKPSALRQHVIDITKQWEGSHRVINLDDWYSSVQLCLTLLKMGLYCRGTVRSNRAHNPRFGMFDKKQIKSVMHGSSLVSVATSLGIIAVSWLDGTVVNMLSTADATTKSFVHRRIGSQTIQQECFSLVGLYNKYMQGVDRHDQLRERFSIASGASFKQWYKKLGFALIDIAITNLYVLYTICEPVNRRDSHLHFQTKLANQMLFETDWTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WN87</accession>
    <name>A0A6G0WN87_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_013369</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000172">
        <property type="protein sequence ID" value="KAF0728797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WN87"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021795"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000237">
        <property type="entry name" value="Pumilio homolog 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF13">
        <property type="entry name" value="PUMILIO HOMOLOGY DOMAIN FAMILY MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22493">
        <property type="entry name" value="PUF_NOP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="232"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="PUM-HD" evidence="9">
        <location>
            <begin position="282"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="307"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="344"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="420"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="456"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="492"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="528"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="564"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="232"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="116"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="641"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0728797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="660" mass="74113" checksum="D49B0F7999AD4C7B" modified="2020-08-12" version="1">MDSKKPHRSISQQRTRTFADASTNPAANSSLFYRDLDFFDRPSYEETQPRPSHTPAHETIDPEMYSAYYDPSAKASDFDALPQRRKSSIEMFLSRSPSQHLGSDFFRMTLGEPTAFNLDGNAPSKPSRSPSLQMPPPQRFGSTNQYEDVDEATWYREPGHHPQLRKDDSALLYSRTNRIHQQQQYQQQQWQHHHQAMNAPPPLPTAAGYGMMRAPNNMPSRRFPALLSPDKPPMLKQCKFFAQGHCRMGNKCKFAHITGGGGSGPGSTASSYDEDYHPFGFRVNPELASPSGLPSESPPHTSISIDDIQGRVFAMSKDQNGCRLLQEQLEFDDRADLCDVIYAESLPHLVDMMVDPFGNYLFQKLLERVSDTQRLVIVQHVSFHLVAAALNLHGTRSVQKVVEICASSSHPLLIELIVDALKEDAVRLCIDSNGNHVIQRALQFMPSEYNQFVFDAVCAECTVVGTHRHGCCVLQRCVDAANASQKKEVIAQVEKHAMKLMQDPYGNYVVQYVLDACLPADALGVMEKCVGHVFELSIQKFSSNVIEKCLELAPDYLRQTFVKEIIASPRMYRMLQDQYANYVVQRALSVASEENCLQLVAAIRPHLASMKNTQGGRRIQARILKRFPHLDVGWDPDYGDLSSPAGPRPMNPHGSYGRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WNI5</accession>
    <name>A0A6G0WNI5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ketosynthase family 3 (KS3) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ae201684_013451</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a fatty acyl-[ACP] + malonyl-[ACP] + H(+) = a 3-oxoacyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
            <dbReference type="EC" id="2.3.1.41"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>acetyl-CoA + n malonyl-CoA + 2n NADPH + 4n H(+) = a long-chain-acyl-CoA + n CoA + n CO2 + 2n NADP(+).</text>
            <dbReference type="EC" id="2.3.1.86"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000172">
        <property type="protein sequence ID" value="KAF0728882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008808"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010758"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016437"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019171">
        <property type="term" value="F:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004318">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004321">
        <property type="term" value="F:fatty-acyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00828">
        <property type="entry name" value="elong_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08950">
        <property type="entry name" value="KR_fFAS_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.25.70:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1400">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013565">
        <property type="entry name" value="Fas1/AflB-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040899">
        <property type="entry name" value="Fas_alpha_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047224">
        <property type="entry name" value="FAS_alpha_su_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040883">
        <property type="entry name" value="FAS_meander"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041550">
        <property type="entry name" value="FASI_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003965">
        <property type="entry name" value="Fatty_acid_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004568">
        <property type="entry name" value="Ppantetheine-prot_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00556">
        <property type="entry name" value="pantethn_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982:SF21">
        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982">
        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08354">
        <property type="entry name" value="Fas1-AflB-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22235">
        <property type="entry name" value="FAS1_thioest_ins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18325">
        <property type="entry name" value="Fas_alpha_ACP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18314">
        <property type="entry name" value="FAS_I_H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17951">
        <property type="entry name" value="FAS_meander"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01483">
        <property type="entry name" value="FASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="13">
        <location>
            <begin position="3223"/>
            <end position="3750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF0728882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="4003" mass="434667" checksum="E98DF38A440DF9F8" modified="2020-08-12" version="1">MTETSTPTNAAPAVNNTVPADSGSVEVVAPTPAIFLDAATGFAVQFGGQANEYIAELTTLVEKYSSVRQFVEDAQTALVEEAKPFDITIHPFLWTQDESSRPSKDELAAAPLSYPLIFLTQFANYLALLEATHLTHEKLLPKLRAGSGHSQGVVAAVLLAAAKTHDELLFLGLKFVRYMFQHGVHAQATFGNVSKAGDITPMLVVRGLAYPALKKAVDAANAKLKLKDSRALQLSLVNQATAIVVTGLPEFLAQLKTTLEKISASHDESQARIPFSQRKPVISFVPLNVSCAFHNTVLAPAQPLIEADLKRIELSIPGSSLQYPVIGTDEAAPNLQLYGEKDVLPDLVKMQLSDVVNWPLTTRAIKNAGGVTHVLDFGPALGAAPLTLKELEGFGITTVVPTSRHKPSDTLPGLDYILSTSSGFVSKSWEALYGPKLAKSVDGKTILHNKYTARLGRQPVWVAGMTPTTSYYGVPLVAAITESGYIGELACGGLPRPVIFEDKVADLLSRLTPGNGIYLNLLYLNAKLWAFQFPMIKKMRLDGIPIEGVTVAGGIPTPEKADQVLTELLSVNIKVVSFKPSSISSIHDVLNIAKKHPAATIVLQWTGGRAGGHHSCEDFHTPLLATYAAIRRTSNVILVVGSGFGSAEQSYPYLTGDWSVAFGQPKMPCDGILVASRVMVAKEAATAEAVKDLLVQTPGIPDESTWESAYETSAGGVVTLKSELGEAIHKIENRGALCWREFDRKYFSLPMKDQEAAILADKDAIIARVNADFQKPYFGRTLAGEVVDVDAMTYLDVISRMISLMYVSSSKRWIDVTFMKRVFAFLQRTEQRFLTKATTTSKLVVQSASQLKADPFALVETFKQAYPAVATTLLSVEDVDFFYHSCKFGGKPVNFIPVIDKELITWFKKDSLWYSEDLEAVPDQDAGRVMILQGPLAVYHIKQKNEPVGDILKGISQGVVDSMVAKSFEQHTTTLSIPQVVGWASSTLDNSNVVLSKAIQEPVSADAWLEELSEVVSTGNWLADLIFSDHHVSGRQWIANNTSQIVAARPGQTVEVEFTGAGVPVALRVQDANVVKSVPVIDISKKDHTITLRLNIQRPATREWTSEVVSLDRVFDYKPASEWSTIHVKDDVSEENVKTFYAQHWIAPHIADCSIALQSSVHATHSATFTVTAEDIAEYNSSLGLTGRTTAPVDFSTVAGWKPLISSVFAKEISGDLLRLVHLSHAYTLLTSDDGSFAAGDVVVSTGFVTAMRNTVSGKLVQGVVVVAKNGVDVVRVQSEFLIRGQFKDHAHTFEKKETSRDVRLADKTATAILSDKAWFTLAADQTLAAGASYKFDLKSSYVYADGHSTLASFDVQGSVYGGANFDQLVGTVAINETGVPKDPVASYLDRVAPVAAEGAKTQCNLLATPVTIEIPAFAGDYARASRDLNPIHRCAYSAAFANLPNGQPIMHGMWTATKVRNLMMDVMRDQFQVTQLKSYHADFKGMVYNDERLFLQVTQSGVSDGLILLNVNVANIRGESVFGAKASVYMPKTAFVFTGQGSQQVGMGMDLYATSPVVRKIWDEGDQHLSNKFGFSILEIVRKNPTSLTIHFGGSLGMAIRENYMALRCQKPDSSSPTGYKTVPLFPEINSMTQSFTFSAPAGLLFATQFAQPALVLMEKALYNEAKSRGVVPNDCYFAGHSLGEYATLSSFAEILSTSSLAEVVFLRGMVMQNAVERDEHGMSAFGMVAANPSRVGSKAFDETTLFKLLDVIESQSKNLCQVVNFNVQDSQYVVAGELVNLEVLSRIMTTVREQPTTLQTVGIEALVEESLVLIRSQKEALVSKGKTFGLKRGTATIPLVGIDVPFHSRQLLGGVPAFRELMRPMLKKEILYGNKALLESHYIPNLVAKPFSTSKEYAQEIVDLTGSPVLTSILANWEATPLDELVWTLVIELLAYQFASPVQWIKTQAHLFNNGLRRFIEIGPSATLTGMASRTLQSGRFPGAKCDILFITKDRDTIYYENESENPSAVDFAHAQAALAAAEAASEEVPEEAEATPAPVAAPVEVAPVVVAAPVVAAPPAAAPAAAVTDEPVSVNHVLRVFLAHRFKKQLSEIDDNATIHGLAAGKSAAQNEVVGELEKEFGGGVDRVPELPVSILATSFKSYKQFGPVFTALTTDFVRKQLPGGFNISQVKSYLSSEFGLGAGRTDSVLMHSLLFPPASRHANEAVAKSWLDTVVADYAKFAGVSISKGGVGQAVGVGMPMMMQSFAAAAPVENVPDVDITAAYGLKAFLAHKFKKKFSEITDSTSVHEFAAGKSAVQNEVVGELEAEFGGGVDGVAETKLGDLAPKFAAYNKPGKYFTSTVAKMLSAKLPGGFSASQLRAYMAQERCLGPKRIEIALIHSLVNAPDARFATEADAKTWINSAGGAVSAGVPMMGGGGSISSAALDALKAQMSTMMREQVNAYQAFMKFDSLATLKKTNADKVTRRELEKRIDLWVSEHGEYYEKGIQAKFDSNKIRIYDSSWNWVMQDALELYFRTLSNAQGGSEGAGVFDRESHLSQMSAFLNADVSQLSKIGEPQNWFKPFLCNRATPELLAATEFFLSRQQASGNLEFAQSIQLLNEEVEKWMERDPVHVQLLQPFRPDVTVEDNGTIVYKEVPRGANSVDYVDELSRGVVYRPDDHKVISPKSGHSSVSLVRGMETAEYDEGHESDHHSVSSEPIRKRVVKRSTHVHGSKLWGLKAVTRRVKRSKSTAHNQHALPYVHIRKSDERDPTLRVLDENMTKELLLSMHEIATAGVSFVGKNALVTGCGRDSIASEVVKALLEGGATVICTTSSFSSKSTKFFRSMYENHGARGSKLILFPFNQASSKDCGALVAHIYEQLNLDLDFVIPFGAISVVGPTLSDIDSKSELAHRIMLTNTYRILGKIIDYKRAKNIRTRPCLAMLPLSPNHGTMGGDGLYAEAKLGLEALMNKWHSEGWEHYLSIGGAVIGWTRGTGLMAGNNIVSAGIEKLGVRTFSQVEMAFNLTSILHPRMVAAAAKSPLWVDLGGGMAQLHDLKVQTDNIRAAITEESKIRRASVEDRKKDSVTDVVDAEKPVLNRANMHKYYSQFPQLPAASELATLGKDYKGMINLEKTVVVVGFGEVGPWGNSRTRWEMESYGKFSLEGCIELAWILGYIKYHNGPLKSGEHYIGWVDAKTQDPVADTQVKSLYEENILKHSGIRLVEPELFDGYDPKNKMILQQVAVDKNMRPIEVASREEGLEYQKELGEDNCDVFEQDGTWMIRLRQGAVLSIPKNLHFNRWVAGQIPTGWDAKRYGIPADIAEAVDPLTLYTLVSTVEALISAGISDPYEFYQYVHVSEVGNTSGSGMGGMRSLRRIYYDRPTGMNIPSDTLQETFINTMAAWVNMLLLSSSGPIKTPVGACATAAESVDIGVETIMSGKARVVLVGGFDDFCEVGAYEFAQMKATSDSEKETSMGRDPREMCRPCTDTRGGFMEAQGAGIQILMDATLALDIGVPIYGIVGVSNTATDKNGRSVPAPGKGVSTTAREYVNGNSDMRDALLDPAFRREQFDDEVEAIEFWKARQLKSIAAGTQTRYTVEMVEEIATKKLKQAQLSWGHDYFKGNAGISPLRGALNMWGLTIDDIGVASFHGTGTNANDKNESEITQRQLEHLGRSAGNPIMVVCQKYLTGHPKAAAAAWMMNGLLQVMQTGIVPGNANNDNTAPELQKFDLLVYPNRSIQTDGVKAALLKSFGFGQAGAEVLLIHPDYLLAALTPSQYEAYVAKRAKRSNGTHKYLQNVLSGKHTFVQVKDHAPYTPENEMNVYLNPLARASYNAKEKTWTFGDVSSAKSAVKAAPSVSSSAAAPNVVELPKKILETSLQQSGSQLILSAGQGLGIDVEPVATFADFASKQVFIQRNFTASEIAYCEASASPASSFAGRWAAKEAVIKAICSANPSASITQGADAPLIDIEVGKATSGSPTVTLTGKALEAFQVSNLSSIKLSISHSGDYAVAQALVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WNX9</accession>
    <name>A0A6G0WNX9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_013330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000170">
        <property type="protein sequence ID" value="KAF0729031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WNX9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012924"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026175525" evidence="2">
        <location>
            <begin position="19"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="621"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0729031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="640" mass="68609" checksum="BB8A5C464FD45802" modified="2020-08-12" version="1">MKVINLVASLVSLTLVHAQCGGIGDIFDYSLPMFKCFDQGNASAFMANPASASAADLAQICQNDDCKTAFNAFNTQVCNRTDDSMAKYYNCGPICNTTHILPLNGALTKCAYAVNVSTAITLNPYWISPYKFNQMCQINECKNAFKTIAALSCALPNEAIRAYFTCTPPVCTANDWYIYNAALQKCAQSANSTTIASNPFGASAQTIAQLCTISDCKKTFQALWNLPCTFPNENLRTNYFCGPNVCNANQLSVLEAPLAKCGQALGSSSLSTNVIWYDGATIDQLCKYDDCRTAFKSIATLSCPLPNETIRTNFNCPPSACNDVDLAPYADAFSKCVVKTDSVSFATNPFGASADTIAKYCKIDECKSVFKSMATLPCIFPNESTRSSFNCISVCNANDLAPLTTSLAKCTQHGGSTSVTSNPFGASTAAIAQTCPIDNCKTAFKSIADLPCAFPNETLRSSFNCIRADCNANDFTSLQPTLTKCGQSITTVVDFDTNIMMASADAINKFCKYDSCRAAFKSIAALSCALYNESTRVNFNCTPVACEINDLLPVASSFSKCAVSINSMSFSSSPFSISADTIAQYCNVDVCKPVLQFMASRQCILPDESLRKNLNCTASASFVHIPGVVVLVASLLAILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WPD0</accession>
    <name>A0A6G0WPD0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_013196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000167">
        <property type="protein sequence ID" value="KAF0729219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WPD0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014557"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF44">
        <property type="entry name" value="PROTEIN AIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="36"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0729219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="244" mass="26853" checksum="CEDCBC927DA1CE38" modified="2020-08-12" version="1">MNCCPPHSLPADPTKSDLAPTKIGSTNTFFYDNPSTERLVLVFPDIFGLDSGRNKENCVNLSKLYKVALVDIAKDYLEDLSNGMEWVHAHQFERCLPKINEVVDHFKSAHGVTKVSAMEYCIGSWVVAKYSVVAGNVLSAGVSFHPSWNAEEFIYGQGSGAKIAEHITVPQLILTAVNDSEWLKPGQEVDQILASRGIPAKLREFPSAQHGWVNRGDLSDDVTAEAYGGAWDEEALPFLQKFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WPW0</accession>
    <name>A0A6G0WPW0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_012895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000164">
        <property type="protein sequence ID" value="KAF0729393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WPW0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002002"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0729393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="365" mass="41156" checksum="3553F2396ACA6064" modified="2020-08-12" version="1">MRPTEAIVPASLPSHEEKRRQAETMRKRRYRAGKRNELNQLKAEVRRLATYLSELKAPQSKSGQLENLEAENSSLQAKLKHLQNLVQALSYWASVNEAPQMGLSYQPPITTLFAHPITRRQGIQWLSERVYHEACRILPLTYPYRGRIEDAMSLDVFLSEDIDEEGATIAGIETQCQYTVCTNFENAAQCSWEHSIGTSPDSLVSRMLIDKVDDRFMYFHHTNSRLGTNALTIAGLFKEANRVVVTNCFVTNDELFPLGDGLQRPHGFSWTVYQSVAPDITLIYNHAVQYTPLSANGRPIPLERIGELFGLSSQGVQHRTAFIEQIRSAAEAAYIHSSRLIIRLLTAEMEATSTFVEPPSEETSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WT10</accession>
    <name>A0A6G0WT10_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_011989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000153">
        <property type="protein sequence ID" value="KAF0730567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WT10"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004444"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0730567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="368" mass="40693" checksum="8C76A5F84220B3B5" modified="2020-08-12" version="1">MVDRGAYDEDYALDDGDEYSSLLQDSRRQTPPHINSYFSQMERMQRERKLRRQMHRYLAMLFGVVALSGWAWTQNSHVELTTTAAARLERVDHRPSFCESRQCIDFIPRSKLDDTCVSAIDPQLFHAMAKYVFETSYTTLWPLDPTLQCTQPKLVNYSATAASTNGVPSCAHYAQVVDIEAVGLFTADGAIERAVATLTSVDATERLDPDVAAIAAHVGEKWSHSNLMGIPGLINPTHDEERGIWLVLELPVELALTELTVVVTTSVADVLLNTTFGLPADTGLVALRLDRELNQEWPAGEYTAVVSQKWKVSFTVLSNDSRAIAASIQNKFILEVTTPSANKTELASACSALTNLTQYCACQASRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WT53</accession>
    <name>A0A6G0WT53_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CBM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_012088</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000153">
        <property type="protein sequence ID" value="KAF0730669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WT53"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003264"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="CBM1" evidence="5">
        <location>
            <begin position="169"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="113"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="115"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0730669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="207" mass="21603" checksum="EB0DA80C903152FF" modified="2020-08-12" version="1">MLSIGKTVQTEGEAALVAALNKQPVSVLVEAGNEVWRNYKSGVITQCPGAQVDHAVTAVGYGTSTHDYFKIKNSWGAQWGENGYIYLQRGVGGNGMCNVVEYISYPTLTGTSVNAPSTSQPTVPPTTSAPTVKPTTAPTFSPTTKPSTTGTSQTTTAPTAKPTSNPSPGGAAAYAQCGGNNFSVPTSCVQGFACKFYSEWYSQCIPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WTI7</accession>
    <name>A0A6G0WTI7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_011897</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000151">
        <property type="protein sequence ID" value="KAF0730789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WTI7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013676"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827:SF1">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0730789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="184" mass="20410" checksum="6E0782FA2582589B" modified="2020-08-12" version="1">MSGVEGTTAVCFFKGCSNLTHPGSWKCIFHRNRRRCLVLDCRNQVYARKLCAKHGGKKKCIVDGCDQAARTANVCYAHGARHVKKTCEFEGCKSPAQWHQRCVHHGGRRKCKIDGCTAFARKDGCCCRHNTTLKATPIKVSSIRLEGFTDGEDDSGVDFDCTPFLASPGPVVWSRDVLDLIMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WTY8</accession>
    <name>A0A6G0WTY8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_011716</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000148">
        <property type="protein sequence ID" value="KAF0730954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WTY8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009306"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="218"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="3">
        <location>
            <begin position="456"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0730954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="554" mass="58419" checksum="01C6470B9B746414" modified="2020-08-12" version="1">MSHPHDLDDLVQLSLADGGPSTPVDAAAIDAIDKPSLVASFNMASYILQFTRVHGPNCSAMDCRSGEVVAHDRLVYSVGAIADGLKHRGFGVSDVMLMLATKSSLRSFLVVLAVWTLGGSVTLVGSPLIPRSSIMATWACIDDNGQIPASTALPRLHTFSLDKDVAGDLSYAELSSLPSFNPIKQAHLTHPSQLALTIHGSDMATLEPRVSSYAHDDLLVAMESAVASSMNFHGETILSLLPLHSPEALTFVWFPCLYFGSSLHLLEAPPTTATDLAKALRAAKPSVLVTTTTRLPDVCKVHDALACLNQVVCIGASVPSLPRTLRALATLSSKWKPEMKFRRGFGSTTTAGVATLSDALSFPIPPTHVRAMGSALASVLVSVRSLTTGEALGPKQVGELCLSSKIAPGSDGGGSRGDCTLLTHAMVYTDASGQVHGIGSKDGIVNLGTESTTTLELEEVLASHPLVDDAAVLIEKTDPAAPPQLVGFVQLASTAQTYLEDALRSVAIFATKQIPPSKHIHGLVAVREIPRSADGQPFRRQVAEESNRLSEIVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WUT1</accession>
    <name>A0A6G0WUT1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_011481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000146">
        <property type="protein sequence ID" value="KAF0731220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WUT1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009803"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="1">
        <location>
            <begin position="416"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0731220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="732" mass="80484" checksum="31CF4E4FF5FDE048" modified="2020-08-12" version="1">MQDDDETTYSDDGQDKEVQKVLHDVLHKRKLYRAKAAQVIERELAAQAKSAALIRIEEPTVVSVQEPQEPNKRKTLRDFELPPFTSTALHLAPASRFVALVAVSTQFQHLPPLDPAFRSAATALHQVLCNVAGFHSTRSKLLINPTLVQFQEELATFEHLDESHTTFLLVLVSHGVRVVQGAHMGTFFLFPESRVTSVEELIVTSLHDQVLAAALNRIPAAHQLLAFDVCHSQNVLPVTPPTSIPTVIQGRVNQEFGRKLLDAMLQLRKEKSKSSPQGPEALPVLILEACLPRTQVAVSQPPDCAFFLRRLADAFRGGGASPRALDNFKNWTEDDFKFPYLHARDICNFVISRVQFDAYRAASRAKEAIQAKGGILSIQFEEAAAVSAIEQTPHVVTDDLPLDFLVGKVPNVPTDAPSTPHFISASMSSLQVAWKMPPAHSDTPILGYQLEICGAGRAAFEKWSMVSTKQVYTLEDVLYNNQPPPQTMVATGLASDAGYCFRVRARNAGGWGPYSSTSPVMRTSAATSSTSYLTDSKAKNTPEEVVAWMSKYEMNGHVQRLGCKALAAFALEGKTSMNNRAASHVVQAGGFKSVLSAMKGFPQDIELQVAGAHVVGLLCLLGAIDKKTAGMPQAKILLDDMLEKYDMATYPQAHSMAQWAKEMIIAPHKRKMGMNEAAMKLQGLFRQRLARRRLRAMASQLFPALVDPTTGLVYYYNTRTGASSWTPPSLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WVF3</accession>
    <name>A0A6G0WVF3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_011132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000141">
        <property type="protein sequence ID" value="KAF0731506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WVF3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001717"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0731506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="411" mass="47019" checksum="94738102EEB8A91D" modified="2020-08-12" version="1">MEGSSGTSVLSAPLESDKLRSFASDAEKEELEALRDEIVQLEREFLRAQVKHQFIQDLQAMTSAERFERQLASIDMDASRETLLQRKKELEQACRQRDVAVQQIQDTLSQIDESREALRVAETEARKMDASNIKAREEWKRLQKLNTQKKTALEMTFNVQIPNVKACAEFLDQQAIAMQEDHEKERLLEDKLLDLTGQVKLAHDALEAHREETTRQAGDAALLEQAKKYTHLEDILHWYQEMQTLVEKLSGFRVVQVDGTLFEVAVADYSIQMQVDPETMKLHSVQVVPPTLDVDDLLEIALDENDIPFLLREVRARAANMAQLQAHLELLGHEGVRCEQQGSLINLTFGAPDEEVHVQVEISSEYGQEHEWLQLHAMEPSNDRIVDTINTSVQCRNLVDLIQQIVHQLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WVU3</accession>
    <name>A0A6G0WVU3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tyr recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_011253</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000141">
        <property type="protein sequence ID" value="KAF0731635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WVU3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021545"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026320297" description="Tyr recombinase domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0731635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="502" mass="56192" checksum="AF1E73BC3753E0E2" modified="2020-08-12" version="1">MIFARTFLVIAWNLICRASNAFAIRNSHMEWSNDSLCIYFAHMKNDQGGERPRDPRHIYANPLSPEICPILALSIYWATFQFVDSVDLLFPGGKQYDRFRKELIDFLDQPYIAEELRRRGVDPANIGSHSIRKGASTYCSSGSTSCPPSTAVHLRAGWSLGGVQNTYLRYESAGDMYVGRTVSGLPINSSNFSKLPPHFSHRTTEITDAINIVYPNRPPQLEFILEFALASLVYHYDKLCETLSPSHPLRWTPFFTCPEIITSLKPLVICGYSSATSVISATGIPPHVSIPSKLDDLKVAMCETTAALKVVSDSIVVGIEKALDDRAVMTSTVSYAGLREMIPDCMRCLPQSIDIRADATTEQPRGLASDDPIPTTRLSMHDGLFSRLPPSFKVPKGTAYQLWILWCCGNAAQDIPPLRLLRSKDLPSRDCQRRMSDLRYLMLRIEREARQTQRFGPISNHDEASRVFLACKDAIAVQNSSRGRSGQLGWRTLVNLIRKNAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WW09</accession>
    <name>A0A6G0WW09_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RxLR effector protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_010976</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000140">
        <property type="protein sequence ID" value="KAF0731670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WW09"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020093"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026233655" description="RxLR effector protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0731670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="144" mass="16238" checksum="8D3AE995C5E0BA43" modified="2020-08-12" version="1">MQKCVMRCCVAVLTFVALVLEMTTPKIRYESTPQTSFEPRWTQENVEEEDPDAETASTKTNFSEEATDISVEDEDTASLEAKIESSESVNTEETKKPIETPTRRCTARVRPMGCPKPMTKTQEQDKCSIKRKTRGGVGARGLRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WW53</accession>
    <name>A0A6G0WW53_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_011077</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000140">
        <property type="protein sequence ID" value="KAF0731775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WW53"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0731775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="67" mass="7682" checksum="14A379BAD2B0520A" modified="2020-08-12" version="1">MHYTPPHNHWTWRTHNAASRYSITGLMHAALVPLGKINLKQRDETCEQPRSRSAITILLSRSTTLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WWP3</accession>
    <name>A0A6G0WWP3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_010868</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000138">
        <property type="protein sequence ID" value="KAF0731915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WWP3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018476"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43102:SF2">
        <property type="entry name" value="GAF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43102">
        <property type="entry name" value="SLR1143 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="39"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="400"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="106"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="336"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="465"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="336"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="351"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="465"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="476"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0731915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="583" mass="63974" checksum="BA6856A0320BAF2E" modified="2020-08-12" version="1">MAMSMSIGTVFVDGSASADEAPRILRQDQLMLPHMYAPLKGATACHECTKTFSTFRRKYNCQMCGEVVCRSCTVLYVAEVSKDVIDAKVCLSCVAIVEAEYHESVASERNSRHTSHSGSYRSSGSADKYSSKSHRASSSIDTSSTALVLAHSSSSVSNLVSKSTPYDYELDFSWAHPWPKPPLVDNDAQRVQVLHSYQIADKEPAFDGVCELASKVLHCPIAAVCFVDERYQLFKASLGLAQEKIPRSVSFCAHAIVSKEPVVVLDTTTDARFQHNPMVTGAGIKFYASAPVCAPSGHVLGTVCVMDQQPHISVDINLLEVLANVVVKKLEDSERLRVPRRSSTDSRSHGRSSSSSQAQGASSSDDEFNNRLFTSSNAPPGLDLFITASDLLPRTQWVSDSKRTTCKVCVQKFSMFLRKHHCRLCGEVICKNCAMSAVLDHTPGSTKVVRIAACLTCLSTRANKRRDDSSDEKSVSSAPTPASSTSSLNQVVLKTTYVPTPPQDMYDEIQTIPVLHRNQSYDVDTNMAIYNEKLVLDYPTPPPVRDFTQQEIQSMLVRLLSQSNDIQQQLSQSVSSSDRALSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WXR8</accession>
    <name>A0A6G0WXR8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ras-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_010645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000135">
        <property type="protein sequence ID" value="KAF0732360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WXR8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013476"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04519">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="512"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="2">
        <location>
            <begin position="102"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0732360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="588" mass="65882" checksum="09D1F644E3098A7F" modified="2020-08-12" version="1">MPAIATPSPYDDIPHLKTFERVVQIELENVQGCEEQFLRSSTGLSSEMKDLGHKYGQKYFSFLLSGALCSSSRLGDLNRDQVMGLATDIIHRMVSSLDKYAPYVLRLSCAYILEKFEAAFPNSTRGPTIVVGGCIILRIVCPALIKPELMGFEPHTPRTLPNALLLAKLLQHAMRGTVFDMSSDELYYANDFIATTKDLVAGYLRAFPSTTKHVLIERLGDAPSTQQDTELRDIQALEPRRRPTTAIIIKSPKESCEDSPKRRFSLLSLFKTKSSGPTTPPATPRCLFIVLSWNQSSLTILAVWRLSHQRIGLDIDGAMGGSHEELDDLRQACSAQHDGRDGLRRKQHLSVWIDISFLSSRNEARPRKNAVLRVAGRAFSARKTLKLPSWMHQDRGSFRPATSFQGPCSTMIDRSLRTVRALFHNVNIAQRWSYELRVPLTRFQWRFWLCVSKVCRRVILASFDRLGTTMVRAVLPRRSLYRLSWAVSSVSVSNSSSSHITRRNRFKSAKRIFTNLTTLNVLVSIILIGAILISLGLFRHRSVRLESAVDANALEPLGQTCRLTSTGFSSCSVAEVATTGDVACYRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WZ70</accession>
    <name>A0A6G0WZ70_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_010142</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000128">
        <property type="protein sequence ID" value="KAF0732812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WZ70"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013124"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054179">
        <property type="entry name" value="PSD13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035298">
        <property type="entry name" value="PSMD13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22037">
        <property type="entry name" value="PSD13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="181"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0732812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="391" mass="44153" checksum="0BFEF19FCA4B0C75" modified="2020-08-12" version="1">MDFLSKEQAKYPTLAAAYARFGELFSRKLYHELTVEILAFVKDESTAHGTNWYDLYAQFISTFQDKINQLSLITICGNIAQRFADPQQAVTFLESIMTHLQTKKNKITQHTTPNPHAIASVLMCRMYMASFQIKLKQLAEVKKILAVNKDTVEGLVGADPIVHAAYYRVACEYYSVVGPADKFYKSSLMFLAYSLYEDIKPAERFALAINISIAALTGENVFNFGEVLATPILTALKGTDKEWLSDLLHAFNRGDIDQFNVIVGAHRAEYNAQPALVNREAYVKEKVALLALMVLVFHRPSHERNIPFADIAAATRLPLNQVEWLVMRALSLGLIKGSIDQVDGIVSVNWVQPRVLESQQLKELQQRLGSWSKKVNETLLYVEDQTPELFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WZG9</accession>
    <name>A0A6G0WZG9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription initiation factor IIF subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_010070</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TFIIF alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000127">
        <property type="protein sequence ID" value="KAF0732963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WZG9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021716"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001096">
        <property type="term" value="F:TFIIF-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008851">
        <property type="entry name" value="TFIIF-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011039">
        <property type="entry name" value="TFIIF_interaction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13011:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13011">
        <property type="entry name" value="TFIIF-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05793">
        <property type="entry name" value="TFIIF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50916">
        <property type="entry name" value="Rap30/74 interaction domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="86"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="222"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="305"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="361"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="375"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0732963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="475" mass="53361" checksum="3CEEBA853E8499EC" modified="2020-08-12" version="1">MIPLGRSKNEPPRRLGTGSLGRGTTSLVGRGPNGLPSSITPQTFDEEYTLRLIPSIKKYNIARFNDGEMPTLAKCVQPIKMFHEPEKIRDDEEEKKEEPQGWNPALRKKRRRRRKDTRMKNWVIQENDSKTLFTGTVEGGVTSSYMLMVKTPNKNEFQVFPVEDWFRFKKPLNYRTLTLEEAEDMNNEKKRAVERWIMKMEKKEGEVAPTTTMITGALRTVKSEDKDESSNIFAEPKAPRRRGPVAKKSAEVDATGDDGGDFTEIFSDDEGQAEVEKVKDEIASESSDGEYEDGANKKALTAEGKALEDLVKRTKEQSENPTADTGNADKDDSDEEEKSASENTVVKYDFYGNPVKETVVAAPDEANGAPAAEADIGKRKAEGEDNRTDKKARTNPPAKPPSSSKAAPKLTEALIQEELIRYGGRMKTKELLKKLKKLLVTADDKAMFKDIVRTICDVEEDPIDGRFMVLKPQFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WZW3</accession>
    <name>A0A6G0WZW3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_009875</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000126">
        <property type="protein sequence ID" value="KAF0733051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WZW3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001106"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21037">
        <property type="entry name" value="MLKL_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059179">
        <property type="entry name" value="MLKL-like_MCAfunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF288">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="264"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="6">
        <location>
            <begin position="510"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0733051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="900" mass="101721" checksum="96E9E04F5F687CD3" modified="2020-08-12" version="1">MGGSDDSTSNFIGSVVDKIRPILDRQDLHAGIRDVLEKALSILQLVNEFETNKMDILFIGLLVAQIAECVADSESSEWTDQHFVLLKTALENLLSYLEVIEEESSRWKEDKTDEKIQIARADEFSIDLSKHKEELENAALVLQLKLQARQDVKLNETNDAVLNLVENVKGVGGIMEHIEQNIESNISKLDAILECAAQVQRSFDVYQRDVSMHNRPSDANIFHSFQMLQDEVDREANKNRQSSRPVNSKEHIKKWMISSKALEFNTEESIGGNDMATVYKGFYMGKNVAVKQFHGILNTDSADLERDVDREIKQWAKVGKLPFVSNLIGVCTKTSRLLIVSEWSPKTISAFLDTRPTRLLQMIYELISGLVSIHDRGIIHGNLKSANVLVTQQNRVAITDFGLSKSVVTTMSRITSRNEPVHMINWSSPEILFAARRAGPPADMWSFGMTVYELLAKDIPFKDYKKFDIERAVRTDHERPPRPADLNPALDPLWHEIEKCWRQNPTERPTASEFQKFIEDNYSVTFEPGRPGNVAIHVHSARSLRNTQAVRRQDPFVEIHVGDRLFKTRPHENGHIAPSWDESFNLECNPAIENPSVSIRVVTKNLMGVGQNEIAHTTLALRDLLTARSVNKQPDHPEHKLGFQLHPNGRIVIDANIITHEDAQSETKPKRYYMRRICANVDDEDCADDPDDGLKSTTVVVGPFGTGKTTLINSILGENMYATSMWGGCTQDVRRIRGAAGFLTLFDTPSYPFSGDQSRLLRMFKKCRVVVIVFDRTVDEVIELVTKARAEKCVLIFVRSKRDLLPHLASPNGPDVSSILESDREDIKRCFGLKDIRNFYIDAKAVLRARLSAANPVNLDLLEDWISLLKAIRIADDKTNEVNYFTNLMESIPSVEEPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X031</accession>
    <name>A0A6G0X031_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_009966</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000126">
        <property type="protein sequence ID" value="KAF0733146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X031"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021319"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43102:SF2">
        <property type="entry name" value="GAF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43102">
        <property type="entry name" value="SLR1143 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="2">
        <location>
            <begin position="93"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="GAF" evidence="2">
        <location>
            <begin position="284"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0733146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="490" mass="53663" checksum="3CBDDDC42356ECE6" modified="2020-08-12" version="1">MGCNGVLDVAFFDKTTTVHPMSIVLQGSSPGESPVKAFFASQEFSSEDYVASDLLSTRTRDASWPYQWEPPPVLPHEDERILVLESYDILDTPPEHVLDMLCAMVVKALKAPIGGISFIDKTRQWCKSSIGLKQADIPRSVAFCAHTIASTEPLIVPDATLDNRFYLNPLVTGPANLKFYAGAPLVNPAGVVLGTVFVYGHHPLEYEAVDVAVLVKVAKMAMNHLEDRRRAASAIRGTGHSTRHHTFHQYQSSQRIPASTYPRPQPQDKALLEAQRTLDILDMPSELVFDRIAGLASTLLQCPIAGVSLLDHDKQWFKAHRGDVPLAEVATLCANVIASTRPLVVLNAQEDSRFKQHPLVKRRGIRFFAAVPIATADGHVVGTVFVMSGAARDATQVDLHSLKRLANVAMTRLHGRIQYTITPVLDYTSFLDASAPVFDIPPPPPPPRSATTGGSGFGLKSRIGNGFQRLRDRFLTAVYGQNGSMPAHYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X034</accession>
    <name>A0A6G0X034_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_010005</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000126">
        <property type="protein sequence ID" value="KAF0733188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X034"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012814"/>
    <dbReference type="OrthoDB" id="10248446at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02413">
        <property type="entry name" value="KH-II_40S_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1140.32:FF:000005">
        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.20:FF:000006">
        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="entry name" value="Ribosomal protein S3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057258">
        <property type="entry name" value="Ribosomal_uS3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_uS3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005703">
        <property type="entry name" value="Ribosomal_uS3_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003219">
        <property type="entry name" value="PRK04191.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01008">
        <property type="entry name" value="uS3_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760:SF32">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="Prokaryotic type KH domain (KH-domain type II)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="Ribosomal protein S3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="7">
        <location>
            <begin position="21"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0733188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="244" mass="26704" checksum="632EE3BB2194E023" modified="2020-08-12" version="1">MALNISKKRKFVADGVFFAELNELLQRELAEDGYAGVEVRVTPMRTEVIIRATKTQEVLGEKGQRIRELTSVVQKRFNFADGAVELYAERVANRGLCAQAQAESLKYKLLGGLAVRRAAMGVLRFVLEAGAKGAEVVVSGKLRAQRAKAMKFKEGFMVKTGDANKEYVDTAVRHVLMRQGVLGVKVSIMLPHDPTGRLGPKRNLDDVVTILEPKEEVYRPYVEPTPVEPVAAAPVAAAPAAFAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X0V2</accession>
    <name>A0A6G0X0V2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_009739</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000122">
        <property type="protein sequence ID" value="KAF0733502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X0V2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004741"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="3">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0733502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="512" mass="56525" checksum="052DC8DA081F7CA2" modified="2020-08-12" version="1">MLLGADYSAFGIAAAASAILVVTLVLRFLSKARQWSHLPQPPSTSFLFGHALETTGAISNWKTLGNYPEPFLSWVKQYGGAIHLREFLEHAVLFTDPAALRHIFVSNGPNYPRQPIAMKYFRDKNLGESLSGVEGKQHDALRKWMNPLFTITSIKSFIGIFNSQTQLYCQNVFDPACDNKAPIDLSTVLSKLMLSITGLTVLGINFDEVPAALEAYERSMIAVSPLVLIGMVTIPGFLSFPLPSLMKRRKYQATLRQIVKKIIQDKLAASSSEEPKDLLDMMFPHSTVDEAVAHTVTFIAGGYDTSSSALSFVFGTLASHPKVAEAIRSEYKNVISKHGSLSSWEAVAELTYTQAVIQETMRINAIAPGTIDRVAEADDHVPMSDGSTVFIPKGTMISTNIAAMHRNPKYWQDPESFIPNRFIEDSSEWNADLALRGGKPHAFHYMPFSFGNKNCIGQRFAMVEMQIIVATLVSKYDFIATSKTDMRQGFGGVTIRPANLEMAVRRVIPSCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X1H8</accession>
    <name>A0A6G0X1H8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_009285</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000119">
        <property type="protein sequence ID" value="KAF0733713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X1H8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016134"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046959">
        <property type="entry name" value="PRK1-6/SRF4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48007">
        <property type="entry name" value="LEUCINE-RICH REPEAT RECEPTOR-LIKE PROTEIN KINASE PXC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48007:SF4">
        <property type="entry name" value="LEUCINE-RICH REPEAT RECEPTOR-LIKE PROTEIN KINASE PXC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026057827" description="Protein kinase domain-containing protein" evidence="5">
        <location>
            <begin position="19"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="501"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="554"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="21"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0733713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="842" mass="93869" checksum="FC01C6602689DF47" modified="2020-08-12" version="1">MRVSALLSWLVLAAEIAAKHRHETTRHPKHHVRHEEEQHHEKTSHQHRHPQSRDDISRESHDEVETGPTPEYPTLLTKKEDSDLRKKTFDTEIEDDNDFMETTEQEVGFNAKGDQPYIVDYHCDPGVAVLSGCTITTNKFVACWQRQNRQGACVPELLREKDEYHALHNPHLYSYAVKRELNGTDMSDGDHSERGMVVQDFADQVVRVDYLPGDASMIDLSDLKSVIFENKTLPDGLGVLRMVNVGLTGYPEPGQFSNITLPKSVFRLNFRRNKMTHFDPKQWLDVPLLEVYLERNSLTNFGSITFPQTIRTLDIRSNLLTGFNGTKLPQAVEILQLANNKLENVRAIPFSQMPRLSILSLQHNMLVALSADDVLPDTLTVLDLSMNKIATIEDGFRFPPKLVRLELSENNLTSISHLKLPASLRNLSIYTNPIVNATFTSEEVARLRNISIIGATPDIQCPPHTSRTYISDTFFICEQLTSVGSAMLGNTPSDGKAGTSVVPIVLGCVAGMVVVTALAVFFARRTNAMRGQDTDFHFFPQGSSKSAVERASSPQTIVLYEPSANDAVQREDELITPVDVPPALKSWKAFLILPTNISDVIPVIGGGYCAVYNSERVLLTPLLDVETTLAMVSTLVHPSIVRFIGVTYDNGERSSLLLVTELQPNGSLDLALTKRLTLTLPQKLHIALNVLEALVYLHGLRQPLAHLALSSHMIFLSEDFSAKVKLPYPQLPNADASNELWTAPEVFDGHETIQADMYSFGVLLSTLDREALPSADLVEWFRLTCPVSLRDLGLECLQVDPSQRPTASDALIRLRQTIRECDANIITLDTFSEMNSDLSSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X2A6</accession>
    <name>A0A6G0X2A6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6570 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_009201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000118">
        <property type="protein sequence ID" value="KAF0734028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X2A6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020768"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046700">
        <property type="entry name" value="DUF6570"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20209">
        <property type="entry name" value="DUF6570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6570" evidence="1">
        <location>
            <begin position="2"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0734028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="196" mass="21623" checksum="6AAB8F2D7A6BECD8" modified="2020-08-12" version="1">MIRSHLILFDAVPGPPATLLPLKLNRDAMYRIVLAGPFTKDQLLKVKQLHLIRQAMVMDILHFYKSNNAFYADVSIDGEFLESLPIEDVPDGIIDEAVDMDEKGVAVDNEQAAVNGFSGDPDEGTSEHECAYVERSVLFTQTTSDMASAHEEKVLDSLGSKICNRTPGSSPSIPEFNVHTSNKISNYFEAGIVFFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X2I7</accession>
    <name>A0A6G0X2I7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_009170</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000118">
        <property type="protein sequence ID" value="KAF0733996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012937"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000170">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF75">
        <property type="entry name" value="CENTROMERE-ASSOCIATED PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="8">
        <location>
            <begin position="4"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1445"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="351"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="505"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="699"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="752"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="897"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1263"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1336"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1450"/>
            <end position="1477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1490"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="92"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0733996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1506" mass="173473" checksum="2B54BC8454AEE222" modified="2020-08-12" version="1">MEESIDVCIRVRPLNERESRNKDVSVLRTIPSMNVISVTDRNGTPLPGAGSVFQYDHIFPENVPTRTIYDEVAKRIVYSTLQGINGTIFAYGQTSSGKTYTMQGDVQSELGILPLAVEHIFQYIEQSTDRDFLIRVSYVEIYNEVIRDLLSDDKEKSQNLKIREDPKKGIYLESHEEIITDYDSIMQLLEQGEQRRTVGQTAMNERSSRSHSIFRIVIESKEKSTSLLHSSEEDVNGAVVVGVLNLVDLAGSESVRYTAAEGVRQREAGNINRSLLTLSRVINSLAQGTESIQNAPFRDSKLTRLLQSSLAGSTRTLIVCCVTPSDRHLEETKGTLQFAARAKNIQLSACVNEVLDDQAQLKRLKRELNELRKQVDNNEMLNALKAENEALAHVKTKHEAEILRLMSLIVTSSSTTPLKKPKAKRGRETWGPGDIMSSLLRRPVALDDDDFREAAQFKRKKERHSEGSAIDTQRQSECEAKVNAHSVAQDCPKICGSCGDAHQTVKDFEALLLQMEKDRTRLQEQVANLELQLQLNQEERSDLLQRLDHADKASSAFEEILEETEKSRNEAIEQMMQIETQQSELQVQLADQMKRTEAAEEMVLALDEKCKRYERTIKALEDSGSDDGEESRKLRQMYESKLQALEEPHRADFNKWSAKQTEWENTMSKLRNDMQEESISLQMANTTMEEQARLSKEAYEALQTTYDECRNDVEKLESILKSKEAEWLKSHEDLVEAKTQVEALHSDLLVKCESLEESNKSLNGKLDEFVNAEQQWANQLNDYEVQNKSLQIQIASLVSEKSRLEELNQDLSTHNEELTAKATLENTTIIAQLEEQLASSVVQRNDLEAQLNVLALAKDEHINRIEAMTIAMQSEEIMHKKLMEDVQDQLFKANVEKHQIENILENLSSEHKALQERLSRININEDSLDRQHQDAELRDLRSENIRLAARAEELEIMVSKLQEQAVEKDKLESIVQELENEMKVLKLKHDQLLQELNSKSGSDSDMELMRQEISEVQDKWKSLTDEHQKKMAENVQLQEKVHDLEGELNTILSKFNVKIQDHTKLLEGQVNGLKNERLDLEAKVEQLYAELESRASSEAKTHQAELDSVRNELQAEMNEKQLLEEKLMDMEERMRKMNEHGSADSSNLRAELLTLKNDLDAQLEEKEALYDKIDDLEKRAYQAEQNAREELHMRSHQWETERETLKDQIDAQHDRIKKLELVKMTKHHLEVFQKMKLDNKKKSEEILMLRQKMEHSSNNGVQIQLIQEQLKHEQAEVEHSRTQMAELKLELKTAQNECNIKASEVLSLQTTISQYQELTASLQRQVQTHDQSYSEINDLRSQIQNYHNRMGNQAKEMEAQKEILHEYQCQLDEQSRQLQELTSQLDEKKRLLESNHLDVDSKMQDLQMKNEELHEKYKADLAYLEKENLELHLELKQTKRMLMEKEASDTPMTRTNLQDIQNLPRTSDVSKQLSAKKSPSVFPMTPGSNKENDPEAIEQRPECNQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X301</accession>
    <name>A0A6G0X301_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Enoyl-[acyl-carrier-protein] reductase, mitochondrial</fullName>
            <ecNumber evidence="11">1.3.1.104</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">2-enoyl thioester reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Ae201684_009079</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 2,3-saturated acyl-[ACP] + NADP(+) = a (2E)-enoyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22564"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.104"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.104" evidence="11"/>
    <dbReference type="EMBL" id="VJMJ01000117">
        <property type="protein sequence ID" value="KAF0734216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X301"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020300"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141148">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08290">
        <property type="entry name" value="ETR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000112">
        <property type="entry name" value="Enoyl-[acyl-carrier-protein] reductase 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000010">
        <property type="entry name" value="Enoyl-[acyl-carrier-protein] reductase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051034">
        <property type="entry name" value="Mito_Enoyl-ACP_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981:SF2">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="15">
        <location>
            <begin position="21"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF0734216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="343" mass="36662" checksum="26295CD5C28F009A" modified="2020-08-12" version="1">MLSRTILRRNFATAVRYHAHGVPTQVLKVEDETVSTTLKAGEVALKFLAAPINPADLHMIRGGYGIKPSFPAVGGNEGVARVTAVGSGVSGVKVGDRVIPAVGGFGTWRTEAVAKEAEVLVVPNNIPVEYAATLSVNPATAYRLLADFAKLERGDVVIQNAANSSVGQAVIQLAKLRGIQTINIIRDDERYAETVEHLKGLGATIVCTDDYLGSADFKRLIADLPAPKLALNAVGGVTSLEFTKALGKNGVVVSYGGMGHEPVLASTTALIFKNVSLRGFWLSEWVKTAPVSERKAMLTELATLMAKGKLRSWVETYPLADFDKALDVAVNRLTKRKVVVLME</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X3L9</accession>
    <name>A0A6G0X3L9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_008896</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000114">
        <property type="protein sequence ID" value="KAF0734436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X3L9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020791"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05123">
        <property type="entry name" value="STKc_AGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000008">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045270">
        <property type="entry name" value="STKc_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PH" evidence="9">
        <location>
            <begin position="45"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="421"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="11">
        <location>
            <begin position="690"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0734436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="806" mass="90668" checksum="0FBB34E5F23C81F3" modified="2020-08-12" version="1">MVGTSSASRMSSSQMMNTSRGSVSEFDMGTDSISLALHPFEDIFETDWEGYVWKQGHVVRNWRNRYGILSGTCFTYYSSKEHAMADFEKFKGRVTITGAKKDENRSNGFVVTTTIDKVFHMYTKTPIETELWIRMIEKAVQIEYYRGTIGASSQLPDIILDGASALNTDRHLQASFANLSLSNNQHLSLSFNGRVSNSTPHLSSAFNTVRHSVGNYGMSRLSMSHTSLSGMSHVPSIRSSVEWKNRNMSSTSHFYNIWTTVLTNYEAKAQHPKECCDELISLFPLCSLDIVVSIHFAIPALPSAVYYGREGLVDFLFCLSQVVSFSDVVVQRVVLSSRPNVLHVTGTAKITNRSSKQSCSAEWKDEVTLSPGGRVLSLKLYVDADPTAFYSTDAEERMSRLKSHLKATSTKRVLSLSMQHFTVKKVLGQGTFGTVVLSERKTTGEIFAIKILDKSSMSSYDKIRTRTEMRILRDVYHPFIAPLRFSFQSQSRVFLGMEYYPGGSLYTHMNKFSDDGDQRIKLPIDLPRIKFYAAQLVLALCHLHACDIVYRDLKPDNIMLDKDGNIALVDFGLSKTNVRSLEGARTMAGSPAYTAPELLKPKRSREYGKAVDWWCLGILIYEMMFARRPFHHPNVSVLYRLIDKDPVKFPGRIPIAHEAKSLIVGLLEKDPNKRLGAHHASDILTHPFFKGIAWDQVLKKKITPPWKPDMSKDLTRRTNVDLNRIVMSKTPAPSSSLFSFFGWRPMETLGKPKPNPIANPDASGEFGRFSYVCDSTPSFLVDEDEMLDSAFSGRRSVQLEALAMEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X406</accession>
    <name>A0A6G0X406_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_008770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000111">
        <property type="protein sequence ID" value="KAF0734526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X406"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010669"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF17">
        <property type="entry name" value="AMINE OXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="2">
        <location>
            <begin position="10"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0734526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="470" mass="53392" checksum="5339C96D728AAF38" modified="2020-08-12" version="1">MKVVVVGSGIGGISAAYHLAKDGHEVVLLDKEEYVGGHTYAIEVDGEQVDLGFMMFGDSNPNIKAWFQQFGITNEDGTTNKRIPMSLSVDSEVPGDMQFSSRKPFGSVLELFSLKKWQVIYDIYKFTVDLLTMPIKSNISTEEWAASGRYSKAFFRHYYLPFVAILWTVPKHDVMTLPASQFLRCLKTHSNSLYIPLWQVIMGAIGRRMDRPKHLWWYIGSAYKAPFLKFFEEHKGVVKTNAKAKLVERGGKAVVLESGERIECDHVVLASHADESAALLPWSTNNKLMDYYFHKSHMYVHRDPSFLSKDKGAWSSWNVRIMEDDQYILTYWMNRIQKLKSKNDVFVTITPGDYKGRKPQNIIMDFPWDHPRRLADCLPEEEIIQEEGISLSGAWLGRGFHEDGFVAGRRAAAIVNDKKHVKTPLYEDPGNVPVPPVPPFGMPWSVSLFFTTVAGAAAFGVYKVAERYVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X4T6</accession>
    <name>A0A6G0X4T6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_008521</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000103">
        <property type="protein sequence ID" value="KAF0734858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X4T6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010402"/>
    <dbReference type="OrthoDB" id="62884at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0734858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="172" mass="20251" checksum="870E72A5A3C85FBA" modified="2020-08-12" version="1">MERAIYDELRKLERLHQKNQVVTVWYVKNQVRLLDQRTALMKPTAAEASDTAKCLLQFAPLIVKLILARRHVQMAMLKWLVNLNSVFGMQTLREVSTSIVAGVLQSSHSIRRQFVMQTLIHATRFDCQILLAEMDRRDLQNRSMRVEMHRYMTAILQEWSHHDIQYNSNFSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X5C3</accession>
    <name>A0A6G0X5C3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_008300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000101">
        <property type="protein sequence ID" value="KAF0735087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X5C3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015922"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF408">
        <property type="entry name" value="OS09G0560450 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="27"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="150"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="200"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="251"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0735087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="404" mass="43992" checksum="F63D0D96894A8319" modified="2020-08-12" version="1">MMASLRPAAIRRASFSTKGCAVEAVKKTLYSYGDGYLGTLGHGSFEQVDAPKAIEAFDGLDLVKASTGWAHSGVVDSDGKAYVFGRTHHFKNVIRGINMRRMAPWFLNFVNKLGGPRSVEAFTPTEVLLPEKVTDISCGATLSFFRTESGALYSNGGNNYGQCGVGHENVSVWEAEIVKMPPVKQVAAGYQHVLALTEEGQVYSWGKGERGQLGYGTVNLSAPQQLVALREKQVRYVDVGFNSSLAVTDKGELYVWGKLMGADAHGRKNGEDQIVPRLVRTSAPVVEAKSSHFHTLLLTEDGKMWVIGRSPAVHVPGEKAIRTNPEMHVSPVAVPDTTDGELDPKRIVRFGTGVNNTSIVTDDGRVFVWDWKDGLVLVDAARDYVVDSFETGFGTNVFLGRPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X6Z7</accession>
    <name>A0A6G0X6Z7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bulb-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_007801</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000093">
        <property type="protein sequence ID" value="KAF0735796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X6Z7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002887"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.90.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.90.10.10">
        <property type="entry name" value="Bulb-type lectin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001480">
        <property type="entry name" value="Bulb-type_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036426">
        <property type="entry name" value="Bulb-type_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00108">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51110">
        <property type="entry name" value="alpha-D-mannose-specific plant lectins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50927">
        <property type="entry name" value="BULB_LECTIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026250688" description="Bulb-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Bulb-type lectin" evidence="2">
        <location>
            <begin position="47"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Bulb-type lectin" evidence="2">
        <location>
            <begin position="248"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0735796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="368" mass="40947" checksum="D6DAC74572DC92D5" modified="2020-08-12" version="1">MLRETSVIAWLWLLSVVGDMVLPAAATSLSEYCEICTSTPALTNVLLSRTEDKVSLNFTMALVSRHQTARLRLQEDSNIVVLNDKNEQVWQAETAGRGGARLLMQDDGNLVLLTAKNVPVWATNTSLQGKAPYCLLLRDDGGIWIWDANCVPWNDPHSINLHLFGGLCCRESYHVVAEELKNSTWNATAEISELQSSHHLSIARTMRIALLKLQWVISSIGLAAAKLIPVPFDYCEICQSSNASSALLSHWTCMNDLTPLKNLESQSKKATAWFQRDSNLVVYDGNKVKWSANTRGRNAAALVMQVDGNLVMITDTLKPVWASDTSKMGQAPFCLHLQDDATLTIWDGRCVALWQNGRKFNPYDNSPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X8C6</accession>
    <name>A0A6G0X8C6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">At2g23090-like zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_007225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X8C6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002445"/>
    <dbReference type="OrthoDB" id="370932at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1050.10">
        <property type="entry name" value="At2g23090-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039713">
        <property type="entry name" value="At2g23090-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039438">
        <property type="entry name" value="At2g23090-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026939">
        <property type="entry name" value="ZNF706/At2g23090_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33788">
        <property type="entry name" value="OS07G0114300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33788:SF1">
        <property type="entry name" value="ZINC-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12907">
        <property type="entry name" value="zf-met2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118359">
        <property type="entry name" value="Expressed protein At2g23090/F21P24.15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="At2g23090-like zinc-binding" evidence="2">
        <location>
            <begin position="44"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0736202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="86" mass="9519" checksum="7BB8F571961FDA92" modified="2020-08-12" version="1">MGGGNGQKSATARERNNAKKAKEAKAKNAPEMRAKMEADRTAVKCKICMMTFMVNVGRNQLNDHWVSKHQDKGFTLEQAFPHLASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X8X3</accession>
    <name>A0A6G0X8X3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Survival motor neuron Tudor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_007516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X8X3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020096"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0736506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="30584" checksum="D23C130997014EAB" modified="2020-08-12" version="1">MAEAVDDTWDDLAILKAFDAALNKHRAPAASVADNKAKKKAQPARPSPAPHTQFKQTAPSQSPSSSTPHEATTSYTQYQQPTPSNKPTQSYPPSYPPHETSIPQAQYQQPTPRYQPMPSYPPSYPPHEMPIPHTHYQSPSTFVPPPSPSPYNPPVYHPHMFEMHRPMYPPEHFPQNLHGPPPSMSSYADAYARAYAQAMTHGVHNSGSPAPPYPYGFNNSVPPGGPSGLPNVPGLSITPMEGDDDLTKLLLSWYQSGYYAGRYKASQEMKRMAYYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X944</accession>
    <name>A0A6G0X944_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homoserine dehydrogenase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_007064</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000088">
        <property type="protein sequence ID" value="KAF0736614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X944"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018287"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004412">
        <property type="term" value="F:homoserine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009067">
        <property type="term" value="P:aspartate family amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011147">
        <property type="entry name" value="Bifunc_Aspkin/hSer_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001342">
        <property type="entry name" value="HDH_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43070:SF3">
        <property type="entry name" value="HOMOSERINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026284236" description="Homoserine dehydrogenase catalytic domain-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Homoserine dehydrogenase catalytic" evidence="4">
        <location>
            <begin position="207"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0736614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="418" mass="45701" checksum="80A0ACDA6C07C6B7" modified="2020-08-12" version="1">MWPWIWAALCVGLALLLQTALHEQHPHPGQTMCDARSVGLVVVGDGSLSQQLLSALEALNKTTRAVDFCGVSFHVAAVGSNRGFIKHTRGLSWEHIHAIKNHTIGGNVLSAWEGLDDDEDLTHKETLGEVVHEIVGHYDKCIIVDCSTDAHIEDLVVAKKYGMGLVLANIHILAGPWKQFHRLVYDEKRDRPSRLVAIDAAIGKGLPVLSTLHTLHAAGDFVTQIKSTFSDAIGHVLAEMDKGASWSDSVTTVYENGLTEDDPRDDLTGLVLARKAVVVARQLGLSVELSSVEIESLIPSKMKNGTLHEFFDHLDYLNQAYQTKWEGAKHRNEKLVYVAGIIVDRGNAVKVRIQLESINSTHALHTANYGDSIAQIRSNHFPHGLILQIGRPDATGTVSAILADIAKLSCVLFTQCDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XA99</accession>
    <name>A0A6G0XA99_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Rab3-GAP regulatory subunit N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_007038</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rab3-GAP regulatory subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000087">
        <property type="protein sequence ID" value="KAF0736884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XA99"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012649"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026059">
        <property type="entry name" value="Rab3GAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029257">
        <property type="entry name" value="RAB3GAP2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032839">
        <property type="entry name" value="RAB3GAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12472:SF0">
        <property type="entry name" value="RAB3 GTPASE-ACTIVATING PROTEIN NON-CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12472">
        <property type="entry name" value="RAB3-GAP REGULATORY DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14656">
        <property type="entry name" value="RAB3GAP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14655">
        <property type="entry name" value="RAB3GAP2_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab3-GAP regulatory subunit N-terminal" evidence="5">
        <location>
            <begin position="58"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Rab3-GAP regulatory subunit N-terminal" evidence="5">
        <location>
            <begin position="186"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Rab3GAP regulatory subunit C-terminal" evidence="6">
        <location>
            <begin position="1060"/>
            <end position="1200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0736884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1227" mass="138765" checksum="76BCC6130B87F800" modified="2020-08-12" version="1">MREVGSIECAVNEILDVAPDQWVCIREDNTNSYFVHGPKVDEKVKLQVSEETLVPIKETRAIAIATTGRFHTVPTTNNTYDIALGFSNGYVCVYNRPGEELFSLQCHRDSVARLEWNFHSAKAHARELYVLFSDKTLVIIEWEMDPTPKRYWRKYSLNGQRDIISVLPCRDTPTSLFQNQPRAGLQTLMAVGCDPVVGFYLAGHEGTSLFRIAHLASAVASRAAGAVWSLARNWGWPQEKENDTIDAVPSDLGMHVALGMPDTQRRRARDLCLSPNGKLALIPDALGRILLIDTTTMLMIRLWKGYRDAQCAWMTQDGPNKGLYMVFYSARRGLVEVWRARHGPRVLCQPIGAQAKLKLATCITKTETACVVVWEKSDGSCSSCTVELDAGSTTTIKQYFAEASHEEESFRLHQLLDGLEGCLTKPDRMPSVLEQMRGLTTIASVQTLVDELHQSKMGALNANFHRDALKTLLEVVRKSRNWADSQAEFSTLVFIFNLEWKAHLIQGYIDLQQEVTPKPFGSLFDEDKLLARMTKWRQVYTFEVKRKTQSLNCLEFIECFAAPWSDPLSSEVELSLGLMLHKKLQDNSSLVECVQHFYAILKSPVLRSPLLDDVLAGLVTIFFAPLSGSVFGIQRVREIHRKLLLDQDNERYTNLFLAWYFALPIDDVLSMTATNASSCLQRWLEPWIQGSSYPHSIDESSFTLPELHPSLQLIFEKCRDTQLLIHAFVLSHHVAHGTIQHANALQDNTLGQVSATGAGLRWEILQQCLSQCLYFSCLLKVPGKLNVKSIESLDELMKFIAIVHLNRPDQELSIPYDPKDEWIDLWQNSSKSHAVMSVLHSFRRLQHAESLVSFRALMLCSAWNNDRSRMTYLELAIQEVENSDFVRQALVVYLWERYIRAQVRSILDYWIEVSSGRSVKKGLDPTIAGEFLRLVLLLLEVLEETCISPQPAFKSPHNDEENVNLSQLLEHVVWTGTPLDVLNLYTETWPASPTSSSLMRQLTTSDSRVMENAVKTHHQLVSVLMAFTAYPSLVVPLKTLFEPSRLCVADCFQSSISADRQDERYEFVMKLLHHDIARGMAVATSFQLPLDKVKQDHAVWLYQSGKDALAEEVLDKVLIESPIVTRMGRVARTRLSLIVSRMQSRSEYAALMSQIPADMTAWICSKEAPLIPDPEVAKLDVAPSLTATNALLHQCVLRLPPGSRELTKCYGMTSVVQRLLEQLKQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XB82</accession>
    <name>A0A6G0XB82_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CLASP N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_006498</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XB82"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007037"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024395">
        <property type="entry name" value="CLASP_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12348">
        <property type="entry name" value="CLASP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="CLASP N-terminal" evidence="2">
        <location>
            <begin position="27"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0737328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="348" mass="39401" checksum="EBB2320A5EB92377" modified="2020-08-12" version="1">MTDSALSMKVAKCVEKLALCGEWIADKKFSKLQRLVRDKAKSEDKDAMLRDVMPLAAPMTKLLPSIKAHVVQATCMLITTLALTLGMSFSPFADQVLVALLHVGQETRLTPEGRVETSNMIRNAGESCLDVLSTHCSYDLDAWMDEYYAPLSGKNIRRLVVKQLGIAMKCRTKAALERYRDRIQDCIHDAIYDHDIRVRQEARAVFCTFSDIWEEDLDDLVHIPPAETRSLLVACYPRERITLALEKQSSPMEMNEPMIAEAVVLKTVVDDATHLSMLDVHILFVMGFLLFLCMSVVSFPVLVRRLQDAVVHPSRVWMHTSQWVANTWTRSQEDLTLDVATWTKTSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XCQ8</accession>
    <name>A0A6G0XCQ8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycoside hydrolase family 5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_005989</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0737993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XCQ8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020494"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35923:SF2">
        <property type="entry name" value="ENDOGLUCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35923">
        <property type="entry name" value="MAJOR EXTRACELLULAR ENDOGLUCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="5 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="9">
        <location>
            <begin position="167"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0737993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="564" mass="61599" checksum="DDC1CF21B564BD14" modified="2020-08-12" version="1">MKRQIEVDAADSIFTPQDGAYEVPDTVDCVPMDSPRQSTVRESVMVEFHAAELLYDEDKRSYSGRIRTWPGLTLLAAVIALSVVLMTHFAMEARKTKQALSLAAQQRQYVIRTIGGGNTTNGTGIDIGPILVDTDGVVGNPKVYPTPKCGLPNYVSKNNKIYSVSASGAEVPLAIKGLNWFGMETGDAIPFGLWANDKNGTTAYQVAAFLAANKFNSIRLPVSIYNIANNVKPNKNMINVAANRAFDVSSYMALLKSVISTLAYRKISVLISLHTLTPKSSGGAWFSDEISKETFLAAVDTLTTNLCNAKFWNIIGLDLKNEPYESTWGDNGPKDFQAGATTIGNRMLKGCPQWLAFVEGVVGTHQVTIGSDTYAYYDWWGGGLQKAGASPVELSIPNKVVYAPHYYTPAVYPQTYLYGKGAVSGGNGVMIGYKELSDDDLRRNIAATMNDMFGYLTKQQDAALVLGEFGGLYATDKHPLKTTKRCTDFTLEVITSSGYAGGYIWSLNPESAYQYNPADQLGNFVEGVLNTDWLTINSDYLQGLKPFDAMPDLKMFPCFLEDST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XCS2</accession>
    <name>A0A6G0XCS2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Restriction endonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_005909</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0737912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XCS2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018324"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0737912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="227" mass="25180" checksum="02CFDE7A84984222" modified="2020-08-12" version="1">MDDPISNAPTVDEYGDPSWEPVVLCPCITWKEFELWLQHNEGRFRRWAFEPLEDGTDNGQVVIYSLPTETHERTAHRVYRSIMRQICRAGNDHHLDDSLFCGSPTCKIGDLGQEADLALTPVGLSVGGPILQSSRGFAFPNVVVEIAYKNDSLPRLRAKLARWMSDETSVQVAIGIKIFPTSLNRTAILRLRGPPAQVTHVAFGAARPGPLQIVFPLVKCLLFGISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XDW5</accession>
    <name>A0A6G0XDW5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">V-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_005872</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptobrevin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000077">
        <property type="protein sequence ID" value="KAF0738315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XDW5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001165"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15867">
        <property type="entry name" value="R-SNARE_YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045848">
        <property type="entry name" value="R-SNARE_YKT6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806:SF1">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Longin" evidence="10">
        <location>
            <begin position="7"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="140"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0738315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="22623" checksum="481F5580BEE02935" modified="2020-08-12" version="1">MKIVAIEILRVDQGDAEPPILVSAFDLNSFNYFKRSTIRDMINFFSRTFIKRTAKGQRQSIQHEEYTCHVYVRQDGLAGIVVCDQEYPPRVAFALLNKYLEEYNKETHGGWASAAGSATAEWPPLNKALEDYQDPSKADKISAIQKELDETTAVLSKTIDSVLERGEKLDDLVQKSQDLSSQSKVFYKQAKKTNSCCVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XE26</accession>
    <name>A0A6G0XE26_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_005709</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000074">
        <property type="protein sequence ID" value="KAF0738479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XE26"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007021"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0738479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="211" mass="23380" checksum="0C2B7998B1CF84BA" modified="2020-08-12" version="1">MAICCPNQDPERVRVKLHGEKQPLSVRPTNLVSHGPIPTPELREAVLADVGSGEMPMRMSVRSSRSGMDPCHVDVPMFVHTCVLMCGRCVLQDNTDFMARVPPPYRRVVRLECVECVAFLVAEAGINANDNANDPGGISDFVEGRYMGSIETTSNFLLFIQGPKYQGGEIESLTPVVQFFELSSRNALALAWGWINNRDVGSPFHFLMVWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XEM5</accession>
    <name>A0A6G0XEM5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_005570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000071">
        <property type="protein sequence ID" value="KAF0738642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XEM5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016538"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0738642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="26311" checksum="943469058B6F716B" modified="2020-08-12" version="1">MPRLNSTAQGPKKKKRSTDLLRRRPRTLTNVMFLGTIPDQVFFATIASFGWLDLRDLLMLSMVSRSFYYTMDHAYWERILKAPMFEPLYQARSFAKLKPRHRAVRIMTSTCPHCRELQPNEIKRRRYEPQACPKCILLPQNQVIQYSEAVATWCLSPDQIDKIPTKNLFIKGRYRQCVKLNDIMELVEQERLERERETTDEHYFQELCRMLADSMHGNIAHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XEQ6</accession>
    <name>A0A6G0XEQ6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ankyrin repeat-containing domain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_005578</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000071">
        <property type="protein sequence ID" value="KAF0738651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XEQ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018358"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052050">
        <property type="entry name" value="SecEffector_AnkRepeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586:SF3">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0738651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="36216" checksum="A9522F09A87FCBA4" modified="2020-08-12" version="1">MKANVVVAAIAANNVALLEFLHDKYNLLSWPQKLLNVASLFGSLDVLVYLDIVEFLHSNRTEGCTTRAMDLAAESGHLHALEWLHATRKEGCTEHAMRIAAQRGHLDIVQWLHRQGYEMARNVMSWAIQTCQVAVAEWIHRQQKDYSYLIYIDPTMSFERTSKMIEWICANRPDIDPSFFLNGAVLRRNDQLVDFLVDRYNVRWSTDLGRTALRLRNMSDILWLYNKNPNVFSAIESKDLERHVTKGNLSLVQWICNEVGYEFPLELLDVAAAARQDKILNWLVETNRYDSQTVEEYNAKPTIHHSHFDYYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XEW7</accession>
    <name>A0A6G0XEW7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_005367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000070">
        <property type="protein sequence ID" value="KAF0738749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XEW7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000281"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0738749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="180" mass="20666" checksum="D93091B5EA026325" modified="2020-08-12" version="1">MSMVLGNSPASPETHDALRVQIAILQAQLDAVEREKCEQEIAFNRQILLLEREIHSLRQIKMRVTPKWFRPLSRPAKGAPKPRAIVTSEEDSSTKQRGIFHRIVSFISLVRLRGFWRPRHKTPEPVSESMEWHAMFDNGRVCFVNKNDSRAVHLDHLVESPQKSSSSRVQDQFGGDSSWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XGH9</accession>
    <name>A0A6G0XGH9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_005144</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000066">
        <property type="protein sequence ID" value="KAF0739223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XGH9"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0739223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="102" mass="11678" checksum="DBFD83167D5E07FF" modified="2020-08-12" version="1">MPKQQGNVNYPTDFIIEVIAEWDAIRAAGSTTTHSEFATLKGIKVETFRTWLEKKEEWACEQARAIVEALKTPKMNDAIEGLKSTEFFMESRITPSVVLWRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XH71</accession>
    <name>A0A6G0XH71_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_004797</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000063">
        <property type="protein sequence ID" value="KAF0739623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XH71"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004196"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0739623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="120" mass="13217" checksum="083AD06C83F97EC9" modified="2020-08-12" version="1">MEAVDIDKLLGDGSICFEGPKRTTTMTTSPSTTSSSGLYDWCDVATSVQRKTYSRKITAATSSSCKTLKKAKKQALLPTRTTFRQQHEAMQRRHGLTGCRFEPRSTAVSTAFAPQLPRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XHJ2</accession>
    <name>A0A6G0XHJ2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Matrin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_004834</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000063">
        <property type="protein sequence ID" value="KAF0739664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XHJ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001207"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030627">
        <property type="term" value="F:pre-mRNA 5'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000395">
        <property type="term" value="P:mRNA 5'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000890">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017340">
        <property type="entry name" value="U1_snRNP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31148">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31148:SF1">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037969">
        <property type="entry name" value="U1_snRNP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="9">
        <location>
            <begin position="4"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="52"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="67"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0739664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="114" mass="12629" checksum="F58C3514C373EB00" modified="2020-08-12" version="1">MPRYYCDYCDTYLTHDSQAGRKQHNRGWKHRENVKLYYEGIIQGQGVTMTPGAWLRPDAGRPGGGAPRPPMMFRPPMMIPPPMGMRPPPLVGGIPPRGPPPGMIPLGMRPPPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XHS6</accession>
    <name>A0A6G0XHS6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_004667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000062">
        <property type="protein sequence ID" value="KAF0739781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XHS6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009673"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0739781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="383" mass="43178" checksum="392F40BDE49AAF03" modified="2020-08-12" version="1">MESKTSVESTRLSTLGYLYSIFTLACSVAYVFILTEYTTNDHFWRNYNVTGANTFLADVINAKLRLGEVGDLDIFAPASLKDYSLPTTVIDVRMSMTRRAMTQPFSLEVAVMSYRANTLFENVLIMMAYCWVDFGHQFEMAHTAKRQLRCAKSYYDNAAVHLESLLRNVNHIDLAESSYGVQINQTILSAVTTIPGGSAWVNYIQNHEWGLSQEVDFWRSYGLTHYATQFQNRYQAGYLNRSAITNALGMSRSITISTVPFFSRSLSLWSTRYINIGWWTDMSKCVPIGATMIRNTNTSVKALGRNWKTIYIGSTTTVGGDIVRASIGPFMSWDTKLITPPSSLLNVIAKFHAQLYDRLRSDLLLSESFQAISESDIDVVPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJD5</accession>
    <name>A0A6G0XJD5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MATE efflux family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_004113</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000052">
        <property type="protein sequence ID" value="KAF0740376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJD5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019444"/>
    <dbReference type="OrthoDB" id="2126698at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13132">
        <property type="entry name" value="MATE_eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045069">
        <property type="entry name" value="MATE_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0740376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="483" mass="52168" checksum="A8AD02AF365F77C1" modified="2020-08-12" version="1">MSSETAPLNATREADHKTIDVKIDTEVTPSAKHELSRMFWLSLPVFMAYLLETLPGSISVGLVGHLQGNNTSLLVDAAYLSATATNVTALAIGFGLACAMDTLCSQAFGAGKLDKLGVYLQSGILVLGSSLIPIFFLLWNAESVMLAFGQDPEISLYAGRFSRVTMWGVPFLFIYELIKKLQQSQNIVLPMMYVAAIGIAVNLSTGYYFTYYTSWGYLGAALGGVCGNIALPVSITIYFYLNESSTKTWWFGFQWHEAVAHSWLFLSLGVPSMMMIAMSWWAMCTLGFMAGMLPNSVAAVSVNAVFGQINTISYVIYLGISVSSNVLLGNALGANEPKRAELLSRLALYGGVGSAFVLGSILLLFRHFIAGLLVNDPVTIENASRSILALVIVSICDGMNGICQGICKGMGRPAVAAGIMLSTYYFIGIPMAYVSGFKWDNGLPGVWYGFASGMVICLSIFIATISCTNWPYLAKLAQERVQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XKA1</accession>
    <name>A0A6G0XKA1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Lysosomal Pro-X carboxypeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_003879</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000045">
        <property type="protein sequence ID" value="KAF0740747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XKA1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008038"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.980">
        <property type="entry name" value="Serine carboxypeptidase S28, SKS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042269">
        <property type="entry name" value="Ser_carbopepase_S28_SKS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF38">
        <property type="entry name" value="LYSOSOMAL PRO-X CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0740747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="398" mass="43954" checksum="C86CDD12E0F0F1BD" modified="2020-08-12" version="1">METLPLLPPRRRQPSSCKLVGVFVGVALVSLLGVLFSQPRTPEARADVEPSFETTSLSKKTETVKESFDGDLRLRCNETFITQTLDHFTAHHATYQQRYFTCAEHWKSPDGPIFFYTGHESNAEEFLKATGLMWENAAEFGALLVFAEHRYFGKSFPKIENASYVESLRFLSSEQALADYAVLIRHLKTTLGAKESPVIAFGGSYAGMLAAWFRMTYPFVVDGSIASSVPLLAFDWDRPDFDPKAYGRITTFVGTAAAGSPGACIPNIRRAQSVIKDFGGSQDGRLALSKALRLCYPPSSQEEAIAVSDSLVDTYSSLAEANFPFPSTFFGDFPAYPYQVACSYLNESTLDDLTLLDRFRASVGVALNSSGQLACIDWNATQPIESENLWAYLQCSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XKF3</accession>
    <name>A0A6G0XKF3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Trafficking protein particle complex subunit 2-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_003773</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAPP small subunits family. Sedlin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000042">
        <property type="protein sequence ID" value="KAF0740883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XKF3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000230"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14854">
        <property type="entry name" value="TRAPPC2L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006722">
        <property type="entry name" value="Sedlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044760">
        <property type="entry name" value="TRAPPC2L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12403">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04628">
        <property type="entry name" value="Sedlin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0740883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="138" mass="15674" checksum="965006F75C6EA54B" modified="2020-08-12" version="1">MIACVAIVGANNNPLFVRSFEEEDELSFHYIAHVALDIVEERVKQSRDDMYLGFLGPVEDFRVYGYITNTAVKFLTVVPDAPVKESELRAFFAEVHKLYVNAMSNPFAQLGERITSNKFQTKVHGLVQQFNSLLEATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XKL5</accession>
    <name>A0A6G0XKL5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_003780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000042">
        <property type="protein sequence ID" value="KAF0740891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XKL5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000223"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044624">
        <property type="entry name" value="Mbb1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44917">
        <property type="entry name" value="PROTEIN HIGH CHLOROPHYLL FLUORESCENT 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44917:SF1">
        <property type="entry name" value="PROTEIN HIGH CHLOROPHYLL FLUORESCENT 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="316"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="527"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0740891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="612" mass="69714" checksum="C5EDB841CA938ACA" modified="2020-08-12" version="1">MLALQRVLHGSLKSNVARRAAGSTFHVHVADIVRPRWNHTAPIIGGYTGTFSGKTGEWEPDRTHLEEVIRKDILMGDVEPTLHGLIRHDIDEARRLFRSVLQLHYHDDMGMWNKWGTMEWKDGKYSLARKIFAKASKIRFDSMLWQSWATMESELQNYIEARRLFKVILATEPADSIQTAMAGLGLALVEEKCGHTEKARRMLKQYHKRFPDDLPVAEAYALFEGRNGNIALARYLFAKEGQRTDTTPQFFHAWAYFEYNLGFYRSALEIVTKGLTYDPYDKSLNLLLALTFAKLEDYDAAREAFQRHMSFAVADPRAFNAFAQFEEEQGNYDTAAKIYEAYLKRDPTNISNITSLAYLQIKIDGKDGVESARQVFAAGAEYTNGIAPLIFNWGVFEEGYGSLDKARQLLLEATEKSPWAADYWCSLARTESRRGDIKAARVILDKATMQCDNKLSLLVALAKLELKNRNYKQAREACVNALKIDKKKASVWNLRALVELPHNPDKAKNIIESALKIIPTQDHNSWAILLCTYGRSHTLLGAYEDAAASFRESIRLDPTNYHSHMYLAGFMATIGEYKEAKDFYMSASRLCPRHKVPMIEKEVDKMSALIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XLR7</accession>
    <name>A0A6G0XLR7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_003418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000037">
        <property type="protein sequence ID" value="KAF0741305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XLR7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002128"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0741305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="262" mass="27373" checksum="87DF77A14F192BD8" modified="2020-08-12" version="1">MSSDDDCCNALCFVCQCVEICCACCEVAAAVPPPQQTVVIAPVQPVVIAPQPVTQVAGYYTKNPAGGVEFVPITQSPQHNTQTAHPTQNHDAATSPANSKEFRSSSLPPKQLNVIFEISTKSRLPPMSDDTGAALCLACECAYICCVCCQAAESASNPPQQTVVITHVQPVVVAASPANQGGYVAGYYVKSPTGQAQFVPAAQPPASPAYAQPAPFVPYQPTQEPPSYNAAQVPPSYNAAQVPPPRIPNNVEFGGSSMGQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XM40</accession>
    <name>A0A6G0XM40_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_003413</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000037">
        <property type="protein sequence ID" value="KAF0741298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XM40"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003726"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005799">
        <property type="entry name" value="UDP-gal_transpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026060500" description="EamA domain-containing protein" evidence="7">
        <location>
            <begin position="24"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="346"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0741298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="369" mass="40204" checksum="3115C1765362D09C" modified="2020-08-12" version="1">MKLAKRVGLLCVAASLMAAGTLCINASKVDGKMPYMSATVMLLVEILKGLICAAIFVCTRSSLSVWLGWTEVLYFATPALLYTIDNNLVFVILRFVDPATLSILWNLKIFTTALLFRFVLGRSITHLQAVSLILLMLGVATTQSKHDVEPMIQHHETLNASSSSSVNVPVPKFVVGMSLVVVACVISSLAGIVTEYALKKNPGTPFVLQNIYLAFFSACFNGFAVLVQVEHMDGFFAGYNTWTWVVIFIQVAMGLTMGIIFKFLDNIACVHAHAMAMMFTTIVSILFFAFELSLEFACGFCVCVVSMYLYHLPVVVAVNGAHGCHDEEYEKVAPSPSASDEATAISIDSDDSTVSPRHKINSHSPRSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XN07</accession>
    <name>A0A6G0XN07_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_003351</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000036">
        <property type="protein sequence ID" value="KAF0741681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XN07"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001387"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0741681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="240" mass="27038" checksum="52A4525BF3B69C79" modified="2020-08-12" version="1">MCPHPVRDGFSCLDENFVDTDEYEGAPVVLKSFRSDVAAQRIEYLKVVYEAMKNANVPNVDSLVHCGKYYVLLSPVGAGGVPFCRFPTDEQTVLEAIESILEALVILHSVGWMHRDIRWPNVIKQANQSKWFLIDFDHAATSPQDNSKDERLSSEEHAPDMFGGSGVHTTAVDIWGIGHLMRSCDCELDPDLIDYCRALYHSNPSKRPTADKALHWIQEYRSHTHHDPSDQTAGLSRLKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XQ13</accession>
    <name>A0A6G0XQ13_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_002489</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000026">
        <property type="protein sequence ID" value="KAF0742589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XQ13"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014236"/>
    <dbReference type="OrthoDB" id="64880at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0742589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="31521" checksum="7FC66B137950F390" modified="2020-08-12" version="1">MSPHDPAPHELEACMPPTEPHHKLDGKNHKRRHHKRRHHHHHRHPSLQSLFYTLSVVVVGCALLLFSMLQRMTLDTTLHDLMNSFVNADFVPHPTRGIVELRIHESRMVQPIDIERELLGTLFTQVLNRQRKLMMEVVKGAHVIIENDNGRFYELFKTISSDTYSRISSHYSNDVQYGVPQGSLLDTLLTGTTSANDSWFQFEGANWDPFQRPVDSFLHCLNYIEYKIRGVQVGPLGTSSHTDRNPLRIPFRNQSMVHNSNEQLVDYHAVSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XRP2</accession>
    <name>A0A6G0XRP2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_002056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000022">
        <property type="protein sequence ID" value="KAF0742992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XRP2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003669"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="UstE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251:SF23">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE (DUF1295)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0742992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="309" mass="35349" checksum="2AC2802029B25A7E" modified="2020-08-12" version="1">MPFSSFAADAIVLNAAFQLTWMTIMYIINMACTNGSMVDFGWPSGFTVMAVWYLMMGTGAWIHRAVLSSMYIVCGARFIMRGHLTQEDHRWNHWRNYWTTQGGFFGIKSVPINFFCFYHCQSLTNIFFMAVPLHVAATNPSPVLSAWEHIGIGVWIAGFVIENIADMQLTAWKAANRSRGGVMRDGLWRYSRHPNYFGEFCLWVAYAVMTLPEATPSQAVLLLLLPGVAYFYLVYFTGAWMAEQVSLKKRGDEYAKYQAETSLFFPRQQGHHLDNFAWKWSFLGASIHEEHTHTPCLSPTPTHLFEFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XS90</accession>
    <name>A0A6G0XS90_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_002017</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000020">
        <property type="protein sequence ID" value="KAF0743228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XS90"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006675"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23810">
        <property type="entry name" value="UBCc_BIRC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116:SF39">
        <property type="entry name" value="BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="4">
        <location>
            <begin position="319"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="80"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0743228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="586" mass="65905" checksum="C3BCA349C8C1F347" modified="2020-08-12" version="1">MDEVLQTAGYKALIESKSSPHLSSESRVGIDDIQTYCHELRCRKSPEAFADYLREQFVFEMMLGQLETLLLEEQSLVALNSPPRESESASPEGTTPTKTTSARRRVPSNPGNMLWKPFYLDQSDGSRGRKCVKEPIEKTAETVLATHILQLWLSLVETCTKMNVSAVYFDDVKAHILDPRFSLIVERWLSEPTVEHIALHKELCSALVALIIYLHNHPFFDSVCFLRPVAPNTQPIQTCLTSFFHVIASLPKQHELAQHFSQWCMDIKYVRPDQPLPSPKGEYQVTMESLKFSSYNYGSSYFECVKRKHPDLSIVVLPGSMRRLNQELVSLPDNLPVHEDSMIAVRVDEDHPHNLSVLITGPRKTPYDSGCFQFRLVVPGNYPQSPPAVQFMTTGKGSVRFSPNLYECGKVCLSLLGTWQGDPWNPVTSTILQVLVSIQGAILGAEFPYYNEPGRERQWGSTQALHAERTAENGGLEPIRLGTVAYAWTDAIQNPPVGFENLVHEHFWLKRKHLLETMHLWLTEGLVSDTPMFYDTLRGRIMKCVDALTALVTSRASENELIDFTSAVANLQAKFPPAGLSSTAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XSG0</accession>
    <name>A0A6G0XSG0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Stress-associated endoplasmic reticulum protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_001930</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RAMP4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000018">
        <property type="protein sequence ID" value="KAF0743304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XSG0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007954"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010580">
        <property type="entry name" value="ER_stress-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15601:SF0">
        <property type="entry name" value="GEO09675P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15601">
        <property type="entry name" value="STRESS ASSOCIATED ENDOPLASMIC RETICULUM PROTEIN SERP1/RAMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06624">
        <property type="entry name" value="RAMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0743304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="70" mass="7564" checksum="4AB231F26C838543" modified="2020-08-12" version="1">MTNASTPAKLRLRSEKHLSNITKRGNVPTSTRVTHEEGYKVGPVLLGFLFFLVVGSAVLEVLRASQIGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XTX3</accession>
    <name>A0A6G0XTX3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Globin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_001332</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the globin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000011">
        <property type="protein sequence ID" value="KAF0744069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XTX3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002764"/>
    <dbReference type="OrthoDB" id="64065at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Globin" evidence="3">
        <location>
            <begin position="93"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="241"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0744069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="274" mass="31171" checksum="9713FF35FAAA6725" modified="2020-08-12" version="1">MGNAAVGRKKNALITLVAKEDVDFVLDDMAQFSFGLANGSEVQHYMPPQFPLIPILSRARLAMCAKSWELIQNAATDKMRQYGKPGIVLFYDEFFYRLLERDRTFAQVFTNVKQRGEVLIKALMFILSMRADNATELEELKNRCRFLGHRHRTFPKVRPHHFAAYTTTCVEVIMYWLGDEASFAVGEAWSNTAGFVLRYVLEPFLYSRTDPYESYQNTSIAAVREITESSAQFGSTRLITSGSSMTIPSERTVDRTGRSDRRTSLEKKEGSLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XVU5</accession>
    <name>A0A6G0XVU5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Inositol-3,4-bisphosphate 4-phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_001058</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009468"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016316">
        <property type="term" value="F:phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039034">
        <property type="entry name" value="INPP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12187">
        <property type="entry name" value="AGAP000124-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12187:SF11">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3,4-BISPHOSPHATE 4-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="404"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="433"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="505"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="571"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="620"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="673"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="827"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="704"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="714"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0744589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1514" mass="168249" checksum="9B25B46E83460483" modified="2020-08-12" version="1">MSIPDKYALSGLPKWLWLVGRDFDWQIGLGRISQLRREQQRKEGRRAEFLLAGYLNIRLSSPHRGILAVLSTYSFGALVNPSFSWVPSMNRICMNCPVEVQSVVDWPSQLANVGIDTSKLSSSTCTFDAVYVSIVYPSQWTNVNDSILCSVNNIAASCVADTTRSSAAFKLTKDMVSSLLKSTSNTFKLLNLNSPTVMTDKPYSSNGTLGVNVTNIKPDCMMNQNGGGNTANMTIIKVVSLQANQSFIPGSMNATITATSAKMGALSTLYINAVSSAAIPTPANFTLYSLLNKTLFLNTFSASISTISVSIMGKTFPTQFNRMADVSDLYGLSFVYKGDPLAQNVNFTITMSNVTNPSATNGSVKEVTLYVRDLNRNPLTSVENVSFVGVDTERFESAYNTYDLVSTILFGVALIIALCVVRQHGLGFTAATCWTDLVSISVVLGLACGVAAFLLWIVYPSAVFVFLYAAQYFFNTNMIVSLCFHWASVLRLQLFRKLTLKSPALYWYIFILAVLAGSLLTCLILFSSKLDCVYSNPVTGSLRMRSLNSSPPSAIGNEVLDSLAMCSMNGYYMLIALGLIIFTVFLISLGGSVMVKGRKLMLNDALPIEAQSAMRKALTIFYCIIASTVVIYVIAVVIYIASYIISKTIENDYRYSGRVAVSGVSDGSRVSTVVWYLFTIWLPQCVPPVLLLFLHYTPNQDDARGTSVADDNGTKPSQITTPGSDRVGELTAFSANVTQSHRRFLNRTATFLEDSANKLHVIVKLKVPEGSLTRRVYVTLDYCTLKAVSLVSPKHKEWKFVEGTERVQVHESEDPQFRSSTLGMVNVPFVAVLSVPVAGLAANTLLRFIVHAEDENKESEFAPILEFVTTPQAVMDAASHSQALTVRAAEESEMTLPELLEQRTHHHSYVAKMLQSSELHVTTVLMDSIGPEAPLSHHNMGNIVRYFQFEPTNGDAGLVVEDLKESRFCNLIPRQFLECLAVERADDVDQAKEDLQAFLSIKKDRVDGGFYNQILQTIQEEGDYNLTKVWLEDRLQRRKEYLSKIRKNVQFLVQRDKQKQYFKASVDKKTEELKFVPVNLHVEDMLVGPADAFVNEEKRRMSNEVRTYDFTTVGAMAAHCYKFKSGGLMSLQNKLGKMMSKHETTDVPWDEQSRHIVDLTWFIKIRKDVCFSQALTALVASFVRKVEMALQHSNPHVGDMMLLQWSELGFLFQVESLLSTHGNEIGMIEDMSVALDMLSVVAFRLVDTKDKPNSRFSFRKKPVTSSSEDGVVQKVKLQELPQASHAKPGQVKYVVTLQVQCGDFELPQRLANGGEISVFPVLFTQGINEMQTIANNTERAKTELQDTINIKNLQPVEEYSRRYISWIRLQTPQDVADGGFAREDEVDKLLSTLRSSVEEAASSLVKTKRTDILTKSSDLCREMGGGRVTICKSAKDRTAMSVTLEQGRLLMKYHGMGFDKFAPTVAAMRSKGVRIENALKNTGKKQFAFNKLQRYAMPEDYRCPENVGGSGNIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XVX3</accession>
    <name>A0A6G0XVX3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_001065</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XVX3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009475"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00173">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058056">
        <property type="entry name" value="WH_TANC1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF17">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25521">
        <property type="entry name" value="WHD_TANC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="TIR" evidence="4">
        <location>
            <begin position="47"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="3">
        <location>
            <begin position="886"/>
            <end position="993"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0744598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="998" mass="111899" checksum="5BDF9F47E95195F9" modified="2020-08-12" version="1">MTSCNRCGNSNVVYLEVRSVWLCANCENTIKEHGEPSTLAFLAYNRPKLSIFVSYGHDPYQLVAMTIKEHLQKRGHYVWVDTEQLAAGRDWESDISEGLQRAKEAKEHGRVLLLMTPYAVRRDGGYCLNEVARAVQLGLSVFPVLVVDCEQPQSIANLPFYDLRDCIPQYVDSTSTPAPLNYGGSVPITTESWDLRLHAALASARFNHKMNRLVGLLELCDTMLAYHVPLIGGEENLGRSHTALAKSESGLALTTTAATSDVESRYFLSYGESCTKLGQRLYRDLVAQGFQVHPLSQHPLTKGMTKEQEYARLDALHWTHALKTGKLVLFVTPGSVGRPHGVCLNEISLAMTLGLNFVPLMIRQCEIPLSICRIQWLDMSDVCSFNATPWDIHDARYTTRQRQLIAALNGQIGLDQEGQQARLFSLLSPFSFQSQISAVTQGYVGRDWVLDEFDIWVKSPPSDARRVFLITGVIGSGKSALAARIIQTRPEIVAFHLASHEGEQTQNGRRCVLNLVYQLTTQLPAYANVLNSQKDPLEEVVFVKSLADLVQDLLITPLETIARPPSTMVILIDGIECFTNADDNLLAMLTTSLSRWPNWIRFIFTSREDPKVQSMLQPYMVPPVALDPQCGPSKRDVRLYLETSLSQDDDDVPPHVIDTLLERTQGLFLYARHLVNAFASGQLTLDNLDNVPTTMGGFLQQTFATQFPAIDKYKNEIRPILEVVCAANEPLTLEALSSIMHLDVYATQKVKSDFGSLFLLGEGGIVMPFHLSLLDWLKDPESAGDYFVDVCHGHEVIGMWCYEEYLRNVRAGIDFTKIEFELETSGVQTTAQRMQMYIVRHASDHLEKSNSMNPECFDAATFFFTDETFLLAVRLLQVRQIGLQSFYHGEIARNVAEDKLRSRQVVGAFLIRYSGTQRSYCVSFIAEATIRGPVFQHNLIYHLPSGSYSIVPPHEVGEGTAIFSDLVSFVEAFLRQRILKEPIRHTGRLNRGISQQMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XW01</accession>
    <name>A0A6G0XW01_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_000702</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000005">
        <property type="protein sequence ID" value="KAF0744869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XW01"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012081"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF214">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026063395" description="Protein kinase domain-containing protein" evidence="3">
        <location>
            <begin position="24"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="449"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0744869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="763" mass="84664" checksum="97F2F77306D2CF3A" modified="2020-08-12" version="1">MLRRSVLQAVAALLWTAARCVHGGSSLESVVAGDLRRQARKVAESTLTTDCADVDFPDRNTTNTPELCIWTPSGLCYAATYAYYNKTYRAPNSASPKASFDGVYANITADYLESLPQETLISLTNLGIKRINPSLSVDPYGADPDMPLQVTNLSLSYNKIASIVNITFPSSLKYLDLSFNSIGNNAVQLSKVSDLATLKLTQNNVTTLANVSFPPALSYLNVSSNGLTSVAPLPSSIFYLYVAPAMTKPNSSRDLSKNKLAKLTNITWPSNLTKLYLDGNNIDEIYLRFSPAIRHICLGNNPLKRLRATRKMLDNLNAHAQFNNVSVCGPQAWNYSELACTTRNCATFGSYAITIENDAVADSALYSHGDGDSNGTTSLHVSIFILCFSAVIISVSVFLELKRRCQRQEYGSFSDITPRHRSIDDSIELHNDIRFDPLYKALFIPPERVTRERLLARGGYGVVYLAMWTSDKGLVVPVALKRMLPDRVENTAYIEYFMDEIRLCSSLNHVNIVTFHGYTWTTLASLSMLSEYMSQGDVWTLLDSDRIRRQLSWNISTDFVMQFDDKPAAFPTDPGLIDANCPFSKETIVHDVVSALVYLQSMDIIHRDLKAKNVMLSADSVAKLTDFGTSRSCGSDDETMTAEIGTVAWIAPEVLKGVRYSTKADMYSFGVLLSELDTMEVPYSKMHLRQLPNGGQEVNIAKTRLAMLVVAGELRPGLSPMCPPCIKALAERCLAYNPDDRPTAAQVLAWLEQLRLRRWRDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XWB1</accession>
    <name>A0A6G0XWB1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_001236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XWB1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021817"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070390">
        <property type="term" value="C:transcription export complex 2"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045114">
        <property type="entry name" value="Csn12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057985">
        <property type="entry name" value="TPR_PSMD3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732:SF0">
        <property type="entry name" value="PCI DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732">
        <property type="entry name" value="UNCHARACTERIZED PROTEASOME COMPONENT REGION PCI-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25573">
        <property type="entry name" value="TPR_PSMD3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="1">
        <location>
            <begin position="209"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0744782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="404" mass="46915" checksum="813C2FC18F73299B" modified="2020-08-12" version="1">MSLPSLVKEISDGLQRKQSAHVAALLAITYDNQSPKAFRENDRAVESACRNVFRGPGEPYGDIVIGLLKAKRFVYEEKYVLGYEEYIAGFIKFLEVFREESNWLAPWLHVMVYDARILALHADKEVSQKKGGGEIHDNVKNAEQHLKRAFSMTVNDRAPAELSKKPATLYIVNQLFKIYFHLNAINLCRNLIRAIELQDFNRFVKRDQVTYQYYLGRIFMYEDQYHKAEECLEYAWRHCHSKYKRNKRQILQFLVPVKLILGVMPSQALLQTYSLDEFLGISRAIQQGNIRDFNQSLDKFQDQFVLQGVYLLMEKLRPIVMRNLLKKVHFVRDKKHQLKLVDFQVAIDVVDGTEMAMDAVESLVANLIFKGYVKGYISHKLKVLVLSKSMPFPPITDVIKDRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XWE7</accession>
    <name>A0A6G0XWE7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Knr4/Smi1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_001172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XWE7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011298"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1580.10">
        <property type="entry name" value="SMI1/KNR4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018958">
        <property type="entry name" value="Knr4/Smi1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09346">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00860">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SMI1/KNR4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Knr4/Smi1-like" evidence="1">
        <location>
            <begin position="37"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0744715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="170" mass="19020" checksum="D7BA2C18FF23FDD3" modified="2020-08-12" version="1">MHPWYIIMINLNLHDICNLVDILSWFQRKKAALPKGSMDPQEVEALEKALGVDIPKALAFLLEKQNGGIFFNEYKALSCDDIIATSETSQSWDSWKRGFIPLAADPDGALLVIDTKRGNAVYECSEAAVGRELGASLTAYFENYRNELLSGNFDFVQDVGLVERSTKSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XXS8</accession>
    <name>A0A6G0XXS8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CNH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_000336</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XXS8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011493"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032914">
        <property type="entry name" value="Vam6/VPS39/TRAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019452">
        <property type="entry name" value="VPS39/TGF_beta_rcpt-assoc_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894">
        <property type="entry name" value="CNH DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894:SF27">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR-BETA RECEPTOR-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10366">
        <property type="entry name" value="Vps39_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CNH" evidence="5">
        <location>
            <begin position="26"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0745308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="883" mass="97932" checksum="F8FEF2D38528A7E3" modified="2020-08-12" version="1">MAAAANVAYEVFDVEIDKSYKGVKKVERVLSSIALDSSTPSLYIADASSSLHAFTLNSERSTKFHQQLKKIYHENIHIIDSWSSCATIVDSKLTMLSLPLSKDSGTAIIEETRGITSLSVQEHAHVLCCLVKQNLMVYDWSVQARRLQLRSSHDLTDKVHVAVCVLCLGSGVALVHFKRKIVLVDLDTGVQRAIPLSDPVLFASRVEGKHVTLDNVLMATKDYGMILRWDTESRRAVVDGRLDWLHPPKAVTAHRPYILVAFADRVDAYNAGSHQVVQSVPTKGTPHQLLTISSVATTDTPPLVLTVTAPCILTLLRMKPLEDQLKTLLLTTRYADAVGIATLCPNECHLAPNERQDLHVKYALQLFQQHQFPAAFAQFLVSGTSGRHVISLFPEELLPRGYNLPRVFQVSPLAPDSLPSALAALVAYLEGLRKSPTDVSRDDAVLFDTVLLKAYVLTHSPALTSFCSTPNAADLGEAELFLRGHSEWESLLAFYKCHAMHRKALQLLEELDMAHPGQYESAMVRYLQSLSDVALVMDFSTRLLVQNPELGLTIFTRRDVPSDLDSSVVLQHLKAIETTELRGSGGASAKDGDNDVLPLENGRALAISYLTQRIYSNDSELPSALHDELVYLLFDAIETERHKSKTSLHARVHLQRDRLGVLRKQLLAFLQSPLAMYHPERLLSRTPMDLLEERAVLLANMGRHEEVLRLYLHDLRDAALAETYCNECYAHHITDASIYTLFLQTYLRPPRTAPAPRSSLLGSIGLHFVAAFMLRHAHCIDVATALELLPPTLEAAAISAYLQRVLELKVEKRRAAQVEKQLLKIENLHVRDALNRANRESIFVDLDSTCGVCGRGLTRGPILHCPEDGALVHYACQSGSAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XY13</accession>
    <name>A0A6G0XY13_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_000418</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XY13"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001275"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0745399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="355" mass="40278" checksum="158704A292211C17" modified="2020-08-12" version="1">MSTPPTPSSSMHTKHSLVQLCLQAIAKHIWCFYTAKLLDDNKANRYHELFQVFDVALVERLRDDGEFVQAIMASLSRNRHARAYAKLLFDNKHILDAKDMAHFHLDFLQRRAEPSKEELQPMSPTEDEIDQTFSVEPRTLAFPLSLDENHKLESLVKQDVPLTNFGAHAISDLIRREDRLERLSLVSCQLGTAGMILLADAIAESKSLRVLDVSNPSWTNSKSHRNYITNSGIKALSLALQTNTSLEKARTVNQLDMIQGVDRARWESCRLQRWHCHGASDLGKMDKGSERCSTRIRRAAKALLDAFERSASLMDLDLEWCDLPPGMGMHLVRVREMKQEAATAKSHYNSRVSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XYN2</accession>
    <name>A0A6G0XYN2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_000181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000001">
        <property type="protein sequence ID" value="KAF0745732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XYN2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003032"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0745732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="490" mass="55798" checksum="50FE2DA0BB687FDF" modified="2020-08-12" version="1">MEVLHGNIARIDDAVAKVNRIRESAEKALSDMCSTTNTLLAEVATSIKQVDSNMKQSRENINAEMKADIMNEFVQFLSENVDVRNTKGLAFLAQAFVWQDTTMIQEFVEESINVVIFSKRPNTTSRPFETPEKSTVPADASSAKRTHLDVDAGDVEQKRRRLSAESNVGTPITSELELPTKATVPATPEIDPVKEEPQDVAAPPVVDVDAFTPIVEKKLGKAFANKWLRIVMRAPWTQWAASFISFLPGRTPGQVDFNRQLQQFFVNHGRALWERYFFLGSTIHSSNTEPSKRFRRLRAAMGNLIYDLYKLEGADVFLFLESHPHPFWPTIFNNPVPLDTAFPNYSRELLAYFQDQYMKRWPTYHGYWTPPVGVDVGYETFRPNAFLEWAASRTADSCLADKWTFIDHEPKFFVSLLASMEEKREGFDLPNCPYVSVVLPKSLPKQWKFPRGAQSKYKWDEKTGHVVENRDPVVKTTPSRRTSKGLCKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XYU5</accession>
    <name>A0A6G0XYU5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_000208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000001">
        <property type="protein sequence ID" value="KAF0745760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XYU5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000411"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0745760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="119" mass="13552" checksum="8D53F0A325770C38" modified="2020-08-12" version="1">MRPSRVANIQLELGLATYATTWTTLLSSLSEARPRQSVGNVGRLLFIIHLMREADLLSLDEYSALKDRIIKKVLLSEDGRASRFEGKRSSESARPSMSRPISSSREQRRRHCFDQFLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W2Y1</accession>
    <name>A0A6G0W2Y1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_019203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000486">
        <property type="protein sequence ID" value="KAF0721217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W2Y1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007814"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0721217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="159" mass="17999" checksum="900E81B6C7D6DA64" modified="2020-08-12" version="1">MEAAKPEIPAVFCYRACHFRDTLPPPSILLMDAVPDNLDQRRMAKEVVLREGIDLSTEELEQQLAIIPEVPREAEPFDPDQLDVGEDELSDDEKEKMRVVLRKCRKFFIKSGNGLPPPAKGAVCDIDVGEAKPLAERARRIRPELLKKLTSCEDCWTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W517</accession>
    <name>A0A6G0W517_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_018658</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000345">
        <property type="protein sequence ID" value="KAF0722181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W517"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005220"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="6">
        <location>
            <begin position="15"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0722181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="367" mass="40358" checksum="53966CC3F75CA82B" modified="2020-08-12" version="1">MVTITQTKLGPLVATFGGISHIGSASVNQDAFFIVSVDPDTLVLGVFDGHGPDVGQLAAHAAKAFFTAAFRDASTLSAFLDHPEQESRRLFHACHRQLFGRFRTFYENQGVSVREEHHEKGVYLVKRFGRTLPYTCVYGGTTATIAVIHHNRLIVANVGDSTALLARPHNETSPESNQDETNLPSHLSILTGHHAPDSKEEYERILSANPHSTLQFLYDHSTDRDQDPIHSTSTTSKLSARYVKNVRHEWATVVSAPPDAKHADSLAFTRSLGDFHLHAHGLSCEPDVTESTIEPGMCLVVASDGVWDVWQYEQVAAFFTGSSQDVEMALDSARICEFMRMNHAKAQALFNGQADNMTAVVCSFHSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W5S3</accession>
    <name>A0A6G0W5S3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PTHB1 C-terminal helix bundle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_018427</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000335">
        <property type="protein sequence ID" value="KAF0722424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W5S3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014916"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034464">
        <property type="term" value="C:BBSome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026511">
        <property type="entry name" value="PTHB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055364">
        <property type="entry name" value="PTHB1_CtH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20991">
        <property type="entry name" value="PARATHYROID HORMONE-RESPONSIVE B1 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20991:SF0">
        <property type="entry name" value="PROTEIN PTHB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23339">
        <property type="entry name" value="PTHB1_CtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PTHB1 C-terminal helix bundle" evidence="2">
        <location>
            <begin position="9"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0722424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="111" mass="12068" checksum="33EDCCC438712D48" modified="2020-08-12" version="1">MLIRYKFDLDDENFAALWAHLSPRVDQAWEETTEAAMTDLLKSKLAVKKESSAATAASTGLELVLPEDTKKLKKHITIVCDRLGKGGLLVGGPARTNDDENETKDGGDPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W6R4</accession>
    <name>A0A6G0W6R4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_018208</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000326">
        <property type="protein sequence ID" value="KAF0722729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W6R4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000638"/>
    <dbReference type="OrthoDB" id="275011at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0722729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="96" mass="10352" checksum="4E0886BAA376278B" modified="2020-08-12" version="1">MTESLLNVPHQVGTIVLDKEGQIVSSSGDLVGPSGEDAARVIQSLLLDCGDLHFLKSQSADDEALERLTIAFPGFQYVVAFSDDNQVYVVKQEGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W840</accession>
    <name>A0A6G0W840_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AttH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_018520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000339">
        <property type="protein sequence ID" value="KAF0722304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W840"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002065"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021243">
        <property type="entry name" value="DUF2804"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35868:SF4">
        <property type="entry name" value="DUF2804 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35868">
        <property type="entry name" value="DUF2804 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10974">
        <property type="entry name" value="DUF2804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0722304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="407" mass="45351" checksum="1B5D82BD75ACD03C" modified="2020-08-12" version="1">MASKPVKSSSSSLGGTVFLAAALSAIVAALYLAQDLEPLTQITSDFFPANKPLVAKAPAQIWHQEKQEYAFGRWKSAIKDIRFHYEGESLWHHVPARFQTKRWHYTSVNTPHYFIAIALMSMQYLGPVFVYVVDKTTLEKWETGVMSPLAWGVSFSASSVDPNSCSSYTGYNLSLCYQDDSWHMKLDSIPLTSEHSKETLPFSFDLKMASREALILSFPLANNPLRPAYVHKGAGYPVSGEFTLGTKRVVVDDGLGAIDWTKSIALHRTEWYWASSNFYSPDGKAVGINLSRRVYDVNGASQENAIWIDGTVCVLGEVKVNIPEKNPNEAKWTIESRQATDKDALYLEFVPAGSRAENVNILNVLTTEFVQPYGHFSGHVKCTAEGKTYDINVQDAFGVVEDHVSLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W8U9</accession>
    <name>A0A6G0W8U9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_018245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000327">
        <property type="protein sequence ID" value="KAF0722646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W8U9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011856"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0722646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="467" mass="54383" checksum="41BE84BC6F637836" modified="2020-08-12" version="1">MFDSNDGTSATRPNPSIKQCSVMKFAACSFEFAFMKTTCILALTSLCAAFQQESGWVLQRNALANDNGFDSSARAPTTNTFNSDLLEDTAESDERYRHHQKHPKVVALSDSESDQTDDVNTYLDDQDAGEVNGQVFLDAKYRKPRYGRHYLDSEDADEAEGEALLDEKYRKSRYGRHYLDSEDSQEAGGEALLDAKYRKPRYGRHFLDSEDATEAEGEALLDDKYRKSRYGRHFLESEDTPEAEGEALLDDKYRKSRYGRHFLESEKANQGEGEVYLDDKYRKPRYHRHYLGSEDASEAEGEAFLDDKYHRHNYLDNEDADETAGEVLLDDKYRKPKKHHYLTWALLSDNDEVVAHGQDDETIQMLLDAQQNRVDPYASKRPDRDDFNADPWHDDDDNDNRKTNGRNLMVNRYRRRRFLLPDRRYRRRRATVQTPSSLLAGVVEEDDDRKTIQFVAERPSRYRRRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W9A9</accession>
    <name>A0A6G0W9A9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_017432</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000296">
        <property type="protein sequence ID" value="KAF0723760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W9A9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021783"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF9">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="48"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="81"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0723760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="179" mass="19748" checksum="23AE29BCC9B16764" modified="2020-08-12" version="1">MSNERLSNATQQELNSMLLEIVAAADENVLMVQDLLSYGADANAKDNEGNTPLHIAAKSGYVNTTMELLGRNADVEEPNNNGWRPLHFASKNGNQEVVKLLMDEGADPLAKTKIGQTAFELGDFFVQAVFEKYYPMPTSIKTAVMVIKKVLVDTKNSTLEIITVSTSIMTQALKFQIHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WA14</accession>
    <name>A0A6G0WA14_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_017999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000318">
        <property type="protein sequence ID" value="KAF0723035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WA14"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003461"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051707">
        <property type="entry name" value="PI-Interact_SigTrans_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336">
        <property type="entry name" value="TANDEM PH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="17"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0723035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="320" mass="35706" checksum="CA821EB5850B429E" modified="2020-08-12" version="1">MSMRRNRSGKVDAGAQKIVLSGWMRKQKAHLKTWNRRFFALSGSTLSYYDSEDISGAPRGVIDVASVHPLPSEANGLLIHCKAGRDEKLICDTNVAYNAWFALLTRATNPESVFEPPPTDAQDNNALDDALDDDESTEAITYRPNPIKMGYVHVHYASTTKQTAEEAVPPPEDADTWNRYFCKVEHDLLNCYSDDTQQHLYVSGMVRNVTLYEGRKYALSVGLNKGRTVILCCDSMEEKTNWLLTLEGALKTAYKVIQARRQQYGGLSGLLRQSSHIYDLDLAPEDQMVIPPPAAAEASLVRVDEDDEDDNNSEASGVWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WAB5</accession>
    <name>A0A6G0WAB5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BED-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_017591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000304">
        <property type="protein sequence ID" value="KAF0723510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WAB5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013804"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="676"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0723510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="718" mass="79794" checksum="2139F793A9A0DFC0" modified="2020-08-12" version="1">MDKMTSTSEEKRRGRGVSAAAREIYAYFDRRDDLEKSGTYFWVECRLCRSAFEEANGGVHPLTKSSVQEPTPRKNILANLKKHIETCPFVLASKKRKQATASSGPLSTKRVRGVAARSRDLYSFFDRRVDLGKTGSYFYVECKNCRAAFQESSGGVHPITQTTVSSPTPMKNVVANLKKHIESCPFVQASLHASPPCSSSSLSQTQLSSLVVRLIAAIPLPPHWIQVPEFTALVDFLRPETSAALPAPRDLMGPLLEMEAAKAMSESIHLMQKQVASGTAVLGLAVDRHGFIWLHAGPCWFPWTPLPNATAYATNNGKETLDALEAAIDEAQALTGLQVAFVCLHGHGLCHFASSRRPSVLFAPWVNITRLVLSQMEPRLSTIMAQMLGFVDLVQKDPWLFDQCLAKMLLHDVHASSIPQQRNLPHVSSLTWSNLHVLCGALLSLRPACIAFADAIAKPEVSPVRDPMFLSGVASIQTLLEPFTTSHKTAADVLMLLGRLVSRKESSEVCIQTAEALWQQMDQPLHIAAAALDVQHASTIRRWLLSNSFGLTVAEVGASVHRLYEQHIAPDPAKAVVEQFCQWMWMDDVDNMPFRHNTPLFWKYMRDQPGFSKLAPLALLLHCVVGVPEDVRSSHANTKLEQVWIASKQDMNPDKRSLGVERRNLAEQWQELVNDSLGQHDDDATTSSIESVQERHNHHVTPIPLRYLFGPQVQRREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WAG0</accession>
    <name>A0A6G0WAG0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_017046</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000276">
        <property type="protein sequence ID" value="KAF0724233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WAG0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001304"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF32">
        <property type="entry name" value="AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="4">
        <location>
            <begin position="59"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0724233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="633" mass="70046" checksum="850762C2D53B554F" modified="2020-08-12" version="1">MHPATTPTTSRPRLPSKLAGNIWQTFQECAHVVPNAVAISVYCTEPRNNAEDSSRLLVYTWQDYATQATILAQRFQAHGLTIGDYVLFQTTRNSAACSIANMGAIGAGAVVCHWRLETHEVESIWQSDEHFKWIVTDCVDKLPFYLTLPHVSGILVLAHHEIDLSEYAGGSSSLVLFHLSTWMTETSRDVAVAGATVPLSTNCILTFQYNGQGHLEPYMLTHDNVLFTATAMATQMRIEISTSDSILAHLPLHAVTSQLIEWYLSIVVRGGPLLFVFDGAPPRSILAQCQPTLFFATPQTWQQMSVDLMALKAQTSSTWLTRWAKTRAIHNAIKLQRVVRPTKSSFGYILARRFILSRMKRKLGLLGARYCAAVLAPISLSLLQTFVAVDVPIYQWFGSAATTGLFCMSGPYMWNLGSCGKALPATQVVISDPTALLGEGHMCIEGPHLSLSVAKDAHGFWHSPFLGLLASEGFVVWNHAMDLILLSTGDWIPPAVYERLFLSKAPYLSRAIVVGEGRAFPCALFVLKLKKDKLMDEAWEKSRSLGSKATNGSEVQKCPLWAVTLDALLDVVRSSTDSSSLAIHAHPILKWRVLTEDIASDGSQLVQVDEHGQERIHRRLVEEKFARLIDAMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WB41</accession>
    <name>A0A6G0WB41_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycine zipper domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_017131</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000281">
        <property type="protein sequence ID" value="KAF0724122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WB41"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018685"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026353846" description="Glycine zipper domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0724122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="254" mass="25405" checksum="816548A4A59485FF" modified="2020-08-12" version="1">MMRFGLAVTFVASSVVVAFSHRSQDMSVLMSHRVAPLDAMAAGVVVRKLWAKKGQAPRPETGPKEIQGRKIGGRVGKVVVGGVMTAGLGAAGAVVGTAAAGPAGAAAGTVGGAVAGSYVGTRAGARAGNKVGGWIGKKLDQRDARKAAQGGDQSAKKPGIITRITNKIISRTPTAQGGGSTPGSPQRQPSGRSSSMQAGATSSSVRQRPGKQVVQSNSGPSSPKHTRNGSGPSSPTKGKLGDLLGISVSPKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WBL5</accession>
    <name>A0A6G0WBL5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_016775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000267">
        <property type="protein sequence ID" value="KAF0724567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WBL5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015772"/>
    <dbReference type="OrthoDB" id="430293at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF3">
        <property type="entry name" value="SORTING NEXIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="1">
        <location>
            <begin position="19"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0724567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="138" mass="15739" checksum="B0616716FFDB0A51" modified="2020-08-12" version="1">MSSLSTAASSEEGEGHLVLKVDVFGSQESLDHDSGKFYTEYVLRCACQGPDGRTRSWETLRRYREFCAIDILLREKYPHLASSFPSLPSKKYLGSSLSSDFVEKRQRELGYYIDALLSLYPQILQDEIVDEFLEVSCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WC13</accession>
    <name>A0A6G0WC13_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_016660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000265">
        <property type="protein sequence ID" value="KAF0724729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WC13"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0724729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="93" mass="10373" checksum="CD494C4DE943EC77" modified="2020-08-12" version="1">MSMSRGSAKNGLACRGRLREARVSMRSWLVLRTVLSAGRAAPRTTMTLLSTAGSWHDYFGRTRTVDSRTRISGDRNESKKESKSKSKNKTHGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WD38</accession>
    <name>A0A6G0WD38_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_016150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000243">
        <property type="protein sequence ID" value="KAF0725379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009928"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000641">
        <property type="term" value="P:regulation of early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044978">
        <property type="entry name" value="GRV2/DNAJC13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36983">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36983:SF2">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1288"/>
            <end position="1320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0725379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1377" mass="153768" checksum="19C67917AB67E1EB" modified="2020-08-12" version="1">MGTAGSVEQRNAIKDVIVLGDSSNAKKRNKDDIIQVLTTFCTVFPLETSTDEAHEGDENALDVKEKRLFDAVHRLLKTAVDTNAMTGDSDESDIVLLILETFKRLLQWRELHKLVPKYSIKPFLTCMMWSPQMALSVLEVILMMKTRPNGLKSSEIGDKIEVMNRRTFADDQGFQVLGSLLTQHRTAPYDNLSTQIMEECLRIFHWTYVASKSTSDAVTLDRITDALLNARLALLWLSHHPKDSLRILSVDLLLELFFVADLAQVTILQDAARDCGALLYMVYFAVVDDEPNVEGEDVESARDSSFRDKSIQLVEMFCAGNSRSKSAMYRILPVDLFVPIEDRPDLISKYSMASIKKSTNMTKTRSMDIMSFRETRFSASGSFSGTAKPVEFQRWLQDARSQGETWQQVMVAARQVHERPNLVWRRDMLVELQNALKDEIDRLNDRTDWDCDLFQVTYASFKAELVVHGYFIDWLIPKLADLNDSYEVDDLVVLAWHLSDRLGVEENPAWRRSCVRCLRLMMRRYAMTFNGQLPVAGLLHRLQTEALDPAFASECFLLFHVAISTARTRATDSLTSGAILTTVVATLERAMESATRLSSFSRASSTLSEADNDVHRLTFASLDDDVDVANEVDSNSLDGSNQGGGGGGSSGGLDAMLRAGINVLAVVMQRAKFFIPQVLEARTVLVRLFGAAFLSPRTIATLLQIIEQLLDNVQDANSFKRTLLPLVLVACSNPQNRGMCHASASFLSTHYTPDQFKTLVEAAVGHHGCGLHLVLSEPLLLAALFNSDHVRAADVIWGSAFRSRLFQYLSDQCGIDTTDGFHDAVDADETVVDVCIGHLFLRSFVEQEGTFRTKWTPKMYHDTIVDLLDKVGKSTFPSEDSSADPMEMQVLVLKALLVLIPRAGQSISIESRIFDTFLTPLKRSLLSEVDQARGGVGLKLFQHMLSPESNNVNAEACLDTLLAHGLDDMNDAIDKTLTPRYLQFVREQPPFGPALSLVTAIFDLAVTMAQLDRGLAALQAQPRFLARLFSLAMPHVVSSAPQIAQDALVCISRLCRYDALARKLLVESGGIVFLSQLCAVLDDTDGSHTTTMGYAAGILQTHGQNNQAVLIQLFTPGLVKMLSKDPSQFLQVLHNHDDLYSAQAIWTTTMQRQLKETLKDEVAKIQVALKAPRAWPVWDPDHFLAADSFRYLYPDVADEVLVSGIYIRLLAPKEMTSMEELVPFTTALLEDYGKTTAALNAMQSRGGFSQKLQDRHEQLRLAVRKIMVAHPQLEMPFEQEFSDTESVGDDISNLVDDATTKHSDDEDEQDQDEGSRLTKEESMQLDEIVVLLHRARLRSAEETERKAWRQNRINRYLCVVQGTARSPVDSCPDATAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WEM3</accession>
    <name>A0A6G0WEM3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_015778</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000232">
        <property type="protein sequence ID" value="KAF0725813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WEM3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006155"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="61"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="366"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="648"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="726"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="857"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="272"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="135"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="237"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="375"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="427"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="443"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="455"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="495"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="507"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="648"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="731"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="762"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="776"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="798"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0725813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="934" mass="103191" checksum="687849BEB6CB1CC3" modified="2020-08-12" version="1">MDLRQILKAKEKPDLGTIKAKLSASYNSVKQQKNARRVCQLDLDIASRAPKPVDEVLNLTTSAPPRAVVSNPSNSPYPPDFNRFKPNLAHLPPEFLRPRPEPVEVAPQVLPASPTRVQPSSTSTSSSKKKKKKQQSKETKTVPSNPHERHRDKQMALRARADEKRASLGLPALFPTRAPILIEASGSESDESPRKPPATSASSASPSREDIWMAALREFEAGQSRVASSSSSSSEPELDKDQEARHQERQAKLKARASVKRAQVEAESRISAVRARAEQAHAEEQARREAEEARLFEIERARIERERAMIEEGKARLAFEKHAKLAAERARLETMRKVIDEQVAALAAQRAEEAAQAARRAEELKQAALARRKKDQLELHRQAKEKETTENSSSPSKEPPLPAVEESIEPLVEPTISVAATQEEPPMDVRRSVVTIQKEKDTSSSSSSSSSSSSSDDESCDDENDNNDEANNKKQAKPPPRPAVRKKKTPVATTRKPTSQKQGSSRQRTKAKPVRAKKKTTTPTSSTPSPLPVRRRRRRQQRGASLPMWMTLGLEKTQSTTQDDWQVHTQAMMRRATRGDATRVNLRSILDANEAKFAPLVEAYKRSRQQAASVANDVELPPVQMESNAPHQDQNTQFHGETIDPETTLEKAQSDQTEIDKGQKTPSKIKHTQPSNTPLGRNGIPEGFVDPAQVSKERALLEFERVKLNAERLKVEQRLAALAAAEKRANRNSNEPTTSFLRPTPPRDKDVAVHTRALQARARMKRKKTPLRRSRAFSSTSSSSSDNMSDYAQDHSMPTRKKTKSVVRHTSRKSRVIEIVEISDESSDEASPPLPPRIIETPAQRTSWFTNLLESAAQEQDDDGDVPEGSSPPEAAGTSLEAEIPTMKVSTETTEAPGDAEATIDTSAAVDEVVVKEATSEEAPEAATDGAMIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WF18</accession>
    <name>A0A6G0WF18_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_016418</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the APC3/CDC27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000253">
        <property type="protein sequence ID" value="KAF0725020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WF18"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000038"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000018">
        <property type="entry name" value="Cell division cycle protein 27 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF13">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="348"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="382"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="416"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="450"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="518"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0725020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="571" mass="64848" checksum="B3A602531A752EB2" modified="2020-08-12" version="1">MMESSLKSAVQRFLDQKVYSSAVFLAERLVSESSSEENIGLLAEAYYRSGEGQRSISLLQNQAPVHSLSPKNKYMLALCCFEAGRLSEAESALMPSKAFGVAHSVNVSVHLDIPNGAAGLYLMGCICRRLNRVAHAIEYFSESLKEDPFMWSAYENLCELGCETPAGAFFGVSKKRDIHEENIAPIEKKNDSRRARPLTNRGKKAMSRTFTEQDGGEAIKRLSFSDDFESTPKSNIKSGDEALLRLLHSLGTAFQHLCLYKCSRALELFQALPAPHLNSSWVQHQIARAYFEKAQYPQAADVFHGIRDMEPHRLAGMSMYSTTLWHLKREVDLCYLAQQVTDFDKRSSEAWCAAGNCFSLQKEHDTALVFFQRAIQLDPTFTYAYTLAGHEYVSNEDFDKAMDCFRQAIRIDPRHYNAWYGIGMIYSRQEKFHLAEFHFRRALEINPQSSLLCCFLGVVLHALQKDDNAIDALHQALKLQPHNLTARYHKANILLSQDRCEEALAELNQVLLYAPKEYTVHLTMGKICKRLGRLDDALRYFNNAMFFNPKESNEVRAAIETLHEEQTDDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WFJ6</accession>
    <name>A0A6G0WFJ6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_015549</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000224">
        <property type="protein sequence ID" value="KAF0726146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WFJ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021671"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47103">
        <property type="entry name" value="DNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47103:SF5">
        <property type="entry name" value="DNA-BINDING PROTEIN HEXBP-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="358"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="193"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="306"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0726146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="416" mass="46400" checksum="F93733B21F3ABE31" modified="2020-08-12" version="1">MASEMPEVKESIADSTSNQAFGRAVKYTTTPTSDDQAHCEFFMKQLIDQADRCQLDDPDRKMLLGLKLSSDKVHPALNQWWVALSKTKNGDVWSEIHDNFMDRFCNRTPRELVDNLFEDSERLEGESVKAYAIRLQSILDDIDVPDHQGVVIFKRGVRHARAESCLENTDKDLCSIADCMKLLRTRQIRLDDPPVYRERMRPRSGSASTTLTSSRSNLSDRSAPSIPEQSPRPNRRNSKVGFQEDPTLAKILEAIHTTQTSQQAFVAQIQQLTEALTKPATPFFAAPVQAQMNVPYTYPSPYAPGFQQQPTPPSTNPVAVPATTQPPGPSRSRPRTDLAPVMITTKPDDMTTSGVKVCGRCDRLGHGAEDCPRKFLRCNLCHQVGHYVGEHVRTCPICKQVGHSASRCPSRPADKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WH26</accession>
    <name>A0A6G0WH26_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_015282</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000215">
        <property type="protein sequence ID" value="KAF0726468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WH26"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005318"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0726468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="334" mass="38677" checksum="82B2E6A4298E176C" modified="2020-08-12" version="1">MQPPTGLATGGFPRTPKLTVMISRCKFKAQHDFFLAKFIPLAAFDRRRIHHRNPSSMLSRRLCGWLTWLVSNDVMRSISTKRMRFGHRLQAHGSPQTRLERSISSTKWSRRCDAKMDRANEDLEDLIYCIQSTLLEPATWLVLEKNFPVQRRHVLDAAKYLQPRKPKSRAVFELILANVRDKNDRTQWITACMRQATAHVDGILDGRCHPRCILAGIDCFKLGGKIFARCGQFETVDFNFQFSVNAHNMMADITHIWNIPLVNSSVDHDKIYFDSEQFYRGFQKEYMCVANDVVLVIGIAGNPLCKLPKRSTKQEPNQRMESPRKLPRLLRELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WHB3</accession>
    <name>A0A6G0WHB3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_015167</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000213">
        <property type="protein sequence ID" value="KAF0726539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WHB3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020919"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="58"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0726539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="141" mass="15924" checksum="5C9F3FE424877F4A" modified="2020-08-12" version="1">MDSKTTPMLYRPPQATVVPVDSSKRNPFAVMQSSLTLSSNLTPTPPSFFRRLDAYIHANNLRAWDVFVAMDLNQDKRITLEDLLDGLHQINFDLSPTEKSDLVDWMHEAVASDGLSFKEFTLALKLRSTLSPIRSKQSKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJ56</accession>
    <name>A0A6G0WJ56_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_014756</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000200">
        <property type="protein sequence ID" value="KAF0727228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJ56"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000140"/>
    <dbReference type="OrthoDB" id="165382at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF9">
        <property type="entry name" value="MAGNESIUM TRANSPORTER NIPA8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0727228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="378" mass="41480" checksum="0E6AE4ED4142E3B2" modified="2020-08-12" version="1">MSTYVRRILEVAQQNANNLVANPQEDNSPEAAEFKWIGLAIVIGSAILSNLGVNVQKLSHVKEERRPIFQQRPYYVRPLWTIGMALVILGSVGDFEALAFAPQALVASVGGGCTVLANMGFAHLWLGQRLGWSDILGTLFIVVGVVLSTLANKPDAQLDLDELEGQFRHLGFVIYFSVMCVVLLSIFGEIRAINRFSKRTHEHLFRRLPYLYATASGIFGSFSVLLAKCASMLLLLTFQGDNQFVYPLTYLFVGGMVATLILQTDLLNRAIMSGDTLSVFPVFQCFWIGSSVVGGVVFYQKYDTLTLFEWISLPIALVLIIVGIYLLTQRADDELASALASGRFGSLMPLSPTPTTTPQHTPVFGSALRGEPTYGSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJJ1</accession>
    <name>A0A6G0WJJ1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_014624</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000198">
        <property type="protein sequence ID" value="KAF0727365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJJ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021850"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22702">
        <property type="entry name" value="PROTEASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22702:SF1">
        <property type="entry name" value="PROTEASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026029268" description="PA domain-containing protein" evidence="4">
        <location>
            <begin position="19"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="5">
        <location>
            <begin position="46"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0727365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="200" mass="21870" checksum="8E2A4FC30EF9DFD6" modified="2020-08-12" version="1">MCFVMRLLLLIVPAVCTALVVTSPWRSLVPHTDADFGGKPEVSESTLVLAEPSDGCSRLRNNVEGKLVLVIRGNCRFDTKALVAQEARASAVVVMDDSTKEHPWQIRMQCHACHTIHIPSVFIPHASGKELMTTLRTSNVSVVLNSTGQIPADKNRGYTLHGIDPSMVEIVSAAFSGLIHAALPYMGYVYASSFFFVLMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WK00</accession>
    <name>A0A6G0WK00_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Presenilin</fullName>
            <ecNumber evidence="8">3.4.23.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_014419</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Golgi apparatus membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The PAL motif is required for normal active site conformation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase A22A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.-" evidence="8"/>
    <dbReference type="EMBL" id="VJMJ01000193">
        <property type="protein sequence ID" value="KAF0727592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WK00"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009756"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070765">
        <property type="term" value="C:gamma-secretase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.100">
        <property type="entry name" value="Presenilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001108">
        <property type="entry name" value="Peptidase_A22A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042524">
        <property type="entry name" value="Presenilin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10202">
        <property type="entry name" value="PRESENILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10202:SF13">
        <property type="entry name" value="PRESENILIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01080">
        <property type="entry name" value="Presenilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01072">
        <property type="entry name" value="PRESENILIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0727592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="411" mass="45379" checksum="A345860D4ED7465B" modified="2020-08-12" version="1">MDLATVVTQINSFVAVVWPVALTMVLASAVAVFVEDEEAARAMSRYLYYKDIDTSMASSTTKAIEAFTNALVIIAFIAVITFAVVLLYKVNCMAGLQTYLMASSATLLGLVGSVLAEKIFCELHSWHIDVISMAFVMYNFAIVGTLSIFYQKGTSADIGRGYLIVTSVIMAWQLCQLPSWSTWAILCGLAFWDLFAVLTPCGPLRCLVNLIQSEGRPMPGLLYEADIHELHKDVRPVQFPAHAAGEPAPNLGTFENQLHEFCRDYNSPNAAHVHNVALHYLHRQHECWRQLYTKYNVTYIRSNRSYPSYAEVFDDRLGTVTESNRSTIKLGLGDFIFYSVLVARAAMTSFGAFAACFLGVILGLAMTMYLLGHFNALPALPLSILLGVCLFVGMSVVGNTFIEFLAMRGIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WKR5</accession>
    <name>A0A6G0WKR5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleotide-diphospho-sugar transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_014216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000187">
        <property type="protein sequence ID" value="KAF0727877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WKR5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010986"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044845">
        <property type="entry name" value="HPAT/SRGT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31485">
        <property type="entry name" value="PEPTIDYL SERINE ALPHA-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31485:SF7">
        <property type="entry name" value="PEPTIDYL SERINE ALPHA-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026300956" description="Nucleotide-diphospho-sugar transferase domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0727877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="439" mass="49987" checksum="EB70C704C6279CBF" modified="2020-08-12" version="1">MVAHGRAAAAVLAAAIVYGKALESNDGTDQPAYDEKTHVHLVYSTGCDQPLRQFLTASLQMSLARVGHVGPLTQLISGCNDEKRAAIEQEPTFYSDFRLHFTKDYAQYTSPNFSEHYTAYNKPFGMRDFLHNAAKKDNLAVAFIDVDYMLFKPVLINQGLQWGKYYQNTTVRRAEDINDTVKDGIALAQNMKAFLGGRWFNDVNRTILNSVCDGLPCKNVSSPDAFEYFEPAGTPYILTRNDWLRMIDNYCDFTVRGRQLQKDWMVEMYAYGAAVANHNIRHTLVKHLGPATPEFQNTEYWQFLDDSMENPCEDLYEPILPADPPVGIHYAMYYGLPGDINQGYMYYKYRIPSDILQCDSLFFKLPPATEWTSITKDFAGDDKKIYWKRHAVWLECTLIKYGNQVLHALKSKLCPHGFNTRQGIILHASQTPKTAMPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WL34</accession>
    <name>A0A6G0WL34_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_014113</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="VJMJ01000184">
        <property type="protein sequence ID" value="KAF0728007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WL34"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003292"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022099">
        <property type="entry name" value="DUF3638"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022105">
        <property type="entry name" value="DUF3645"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051346">
        <property type="entry name" value="OTU_Deubiquitinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367:SF33">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367">
        <property type="entry name" value="UBIQUITIN THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12340">
        <property type="entry name" value="DUF3638"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12359">
        <property type="entry name" value="DUF3645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DUF3638" evidence="8">
        <location>
            <begin position="213"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3645" evidence="9">
        <location>
            <begin position="550"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="991"/>
            <end position="1018"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0728007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1220" mass="137176" checksum="844003D2642F3DEE" modified="2020-08-12" version="1">MAPCPKHRQVLNCPHQNSVLELESPPVSADIVTSVEEELCRQVIVNIPRAVHEYPLSESRTSAIGLEIADGLKSSWLHHQEAHYFTLADPPGLVTVVEYLNVKVIGYKNSMEEFLRASLNIVPSDMKPMMDLLCASNRHPRVCVNDWLRLAVDDSIVRKLNPYFSQTAASKYQSATRVYLALCVLSLRLARLLNILKTSGSNESLFQELLCKRTWSWDDHPRWLVFEVEQSLQIRPEQYTIVKHLLESPTGTICQLNMGLGKTRVILPMLILHYAEQGLVPRVHVLASILQETLDMLHLRLTASTLAIKIVEQPFHRQIQLTPLQTEVLRQQIQDSCHVVTPEHRLSLEMKVKELACNQDPLANQLQMTIEELKFVDLFDEGDALFHFRYQLVYAIGSPTMLEQYELRAKTAHALLRVLNSSDPPLETWIKKNSRAESASSAAIFRAIRLGDASDITRQEFRLLILRGLIANPTPEFAWLRVWCEKHPKEIASFESILIDSSLSAASLRDMFGVSLHYNYLLALRGYLAFGLLEHSLEQRHQVDYGIDFRRKKRVAVPFRAANVPSDRSEFGHPNVSLLLTTLAFYYQGLTPQLIKEGLEVLLTLGRPAQTFIFDKVLAPLKSELSCEEFALIENVSSLDITNANQMELLCTKLCRSMEFINFWLIRCVFEADLAQHPACISVSSWDLAETGHGKGLLATNDTTFVLPLQVTSSNPFIPSILGTNGRMVDRLLNHTLICQFLPSESKELWKTLVESTINAKVDALIDTGSLLTGVSNSEIAAYIASNNGLEGKHLGIVYFDTSRRQWMVLTRQTQQTFQLNASPIKERNCFVLFDDARSRGADMRLRIDAVAAITLGPKLTKDKLMQGAGRMRQLGHNQKLVILAPNELEKVLTPFCAQTTLEWVINNTVSDLEHGLVTWSQQGLSFCKKLEATSSEVIDESWNLEDLFRDGVVKGSLAETVSSQLKKYGESKKDFLANIKSRCLDLGREIEVQMQYFKECEQELQQEEEQQHEIQAISSEKVMAKEQIWDYASALKATSVQELDISVKPLAYVAQVAAAEGLALVKWPPTVFGTINFFSTIKSPSLDNIRLADAVLVLPNGEWVLLSDKEADAILELLCENSETSVGYINFSALKSSPGYSSKGAMLSFNIDSVRDNEVVALALFNGETMFPGAMQQRIIKYMVAEQGCHQALFDLLAARGKQQNWDCSDLKQCCAFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WL90</accession>
    <name>A0A6G0WL90_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_014042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000183">
        <property type="protein sequence ID" value="KAF0728035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WL90"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021377"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0728035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="119" mass="13883" checksum="79C1B8BE9865E739" modified="2020-08-12" version="1">MSEDEKCHDTYHQPTGLTGWHDKNSRELDPGSCFSNAGANVSFQHGKDKYYPYKDFNKVFPNWSQPIKKQPLRLREYMFCNFQDNLVAMYARPKKCTVIPCEYNHSLQDIKQTISALIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WLP4</accession>
    <name>A0A6G0WLP4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_014020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000181">
        <property type="protein sequence ID" value="KAF0728195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WLP4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008956"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="49"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="219"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="401"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="895"/>
            <end position="997"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0728195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1097" mass="126270" checksum="8FDD7EEEEC4BEF09" modified="2020-08-12" version="1">MWSALFGSDEDTSGQQADQPEHDKLYGAGDEPDAMTMLLGRLTHLLERLGEAEYSKKKWEEQARKLERANQELKYQLDNSTDPQLRERIDDLVAMNEALKEVKVTLEKDLESKEGAVRQQVETIAQLEEKMASLVSESESLSINLELLKESTEQEIERLKHNSDKQAEELAHALIQCRELQAGRDIDAHKLHQLEQDHRASLEKVHHEYSVQIQNHQTHQQVELQLRQELVTYQELRKQAAEEAEAERLKVQEVVHQLKQLEDELHKKSAIESQAQWKEEAIKSLTHQVQSAQKELSRTMEMNLELTNQNAWFEEQIQQYQALQGELESANENARYYKSHFNALQAEKDTNQRMWEELLESERTLGQQRLLEIEELKTALNSAQSAGESSKAVVESIQVESENMRAQVGQLTSEIQSLDQQWTEKYDNAIAETTNAKYLLSCHEEQMKRLTLQNESYQEEIESLKYSIENSQQPTLSPEDQEIIDMHESLLEEREQLRTEVEMSRSEIEQLKHTLVITQENMSALVEENSATNEQLLALETEKDQLLDEHAIAYRHLEDAIHQKDITLDEFQTKLAMAENKLAEWEAKSADNISKIAQLEQTINDLQHQNSSLEASQDQWTQINEEKEQLENEIASIKSHFEETKQILLSEKENLTAKLTNQTEEIESLKQQIHNSEEFAQECEATALEWEEKFDQIYNELASVKHSMEQAQSEAADEKNVLLQELESLKRSSTIALENESKKVEESQFELLEYQEKAEILQSECDELRQTIQQLLSTKDETQNGKAQLEVEIQRLKDLLNHEQTQKTVEVMQLQARLEAALTESEHSRNVSVANEARAQQLEIALKAKKEESVQLRSENQHLLSTLENGKTVYEVLKGKHQQLLDEVQASTSTVDEKESQIKQLTVQINKQNEEHERERAELLKELASSKKMLENVHASSEMSSQNLEDHIRELQEQMHSNNNKFESETEELLEEIASLNGQLSELQVQNNVLSARAHRLARDLSQYVKLPADDMALVLNPNTPNLWELLANGMEQLKSDLEIASTYAANLDQMDTMDNLQDGNFSFGSSADNSQEIVFIDHQTNGASQEPVAWNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WMM8</accession>
    <name>A0A6G0WMM8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sin1 middle CRIM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_013560</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000175">
        <property type="protein sequence ID" value="KAF0728599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WMM8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010922"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031567">
        <property type="entry name" value="CRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008828">
        <property type="entry name" value="Sin1/Avo1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031313">
        <property type="entry name" value="Sin1_PH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13335">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT MAPKAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13335:SF1">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT MAPKAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16978">
        <property type="entry name" value="CRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16979">
        <property type="entry name" value="SIN1_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRIM" evidence="3">
        <location>
            <begin position="172"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="SIN1-type PH" evidence="4">
        <location>
            <begin position="429"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="69"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0728599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="788" mass="86654" checksum="D8DE5996C9BCF661" modified="2020-08-12" version="1">MQLSEVSELRSLIGLMRINTCNSPHFHDRQDSEVDRIYNSSPKVASYELRSSWLDRPSIQMAMPNQTATIASSHDGSPSPKPKPPTVKQPSTEAKDKQTNGKPKVVVFDKKKASKSDGSAGDGDEDSFVFEREPVESIRVVESSLLDLALRGGAMGGALAMGANKPPIDSPVIEFKIYLPNRDEMPVDLYEVSTVEESIHAILAAHQNEGREPKLYYGHPECYELRLHDADGYPDEDFPALDRSRKIKNFGGHEFCLCERPEACPPQEGATASFTAPVVDTNRSFHLGQSEYNTRPRVPQTSNFLKIIMPNENYSVIPIKDDTTGKDLLPQLTRKHRLPMLDEYILKVSEAEKVRLELPSEIIDLDRKLKPLGLQEVTLARRVYADAPVITSAPSSETLASSSSVDSTINKNVRPPPSTFMYNDVKAAMYKEWRVIKTNKYGKRQHRMLGLDSHKVYNSKVGERAMISRTNIKVAERPISSITWLRFLNDPCDFQIHYSQPDEETIEYTAASAYECAEIVAKIKYIQEMNKRNLQASQIVLMVKQSSTRSVSECVLLRSTKGLDLEATAVAATTSTFELAALAADVWLDVVVGVHAVQGGSVAEVAVHFTGSLAAAQQDGVLALRGTQSELIEGQHFTASLQDASAGVFSEAQGADGELRHIKETDIISDGANHNGDLVLLVLHVAGHAGNRHGRLVGAAHVQTLQHVFVELGVRAASQEAVQSDEQVQVHVFGLRASAGLAARALATSNDILSLFTRSVTFSALHNSTYHLSSLHGETENGKRFPIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WNN6</accession>
    <name>A0A6G0WNN6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_013287</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000170">
        <property type="protein sequence ID" value="KAF0728986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WNN6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012455"/>
    <dbReference type="OrthoDB" id="78222at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0728986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="143" mass="16444" checksum="216FCFF2BA8A8BEC" modified="2020-08-12" version="1">MERTCSFTHVDFQLECKSGIVSIGSFSRFMTLVGICVGSIATCYLYERLRHPSLPPTRQDSLFLSSSAKHVYTSIRWMDNDVYHLDTASAAINGLLSVRLANVFYVFDLKIWRIFVIEDPPEKRERLERHGEHHLLKAIPLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WNV0</accession>
    <name>A0A6G0WNV0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_013338</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000170">
        <property type="protein sequence ID" value="KAF0729039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WNV0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007488"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13999">
        <property type="entry name" value="STKc_MAP3K-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF214">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="223"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0729039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="496" mass="55217" checksum="CF2FB77936E6BD5C" modified="2020-08-12" version="1">MNSKLTSIPTDLPSSLTKLQLDSNPISTVPKLPPTLTFLSMANTTITNWENMDFSNLTYLDISSTPLKTINNVTFSSKLTSLNLTNLKLESWVMTQDTFNVVNRISIPIGVDVPNVTLDLNESTCQDTTRRYVLSSLCSAKFRTCNICIQQGPSKTTKAIPAIIGATAGSVVVIGILVWVVVRRRNRRRRDVESPNKSYTTLSDSRDLDMKDLAIYRIDKKDLHLEDFLGSGAFANVWRGSFQGEYVAVKALHDHRVALEQVQAFVDEIALLGKFDSPCVVRLIGAAWTRPANLKCIMEFMDCGDLRDYLVHQSSQDFPWSAKMQHIYNIIEGLVYLHSLNIIHRDIKSRNILLDSTKGTKLTDFGISKEDIQATMTVGVGTFRWMAPEVIQSQYYTTAADVYSFGVVLSEFSTHHLPYEDLTNPSNGQPLGDTTIIVKVVAGQLQPTFAGDCPEKILDLAQKCMALDPNDRPNATQVARTVLTLLERHSAPGYLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WPH6</accession>
    <name>A0A6G0WPH6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_013051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000166">
        <property type="protein sequence ID" value="KAF0729305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WPH6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018381"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0729305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="154" mass="17261" checksum="EA26462D452A164B" modified="2020-08-12" version="1">MMTAKMPTTTTATMMPLGRPYRGQCKYKGGRCPNERTIKYTGEPHTLCEAHRLHHNKIQCKSDTKMRQLKRLMAERQSKSMALLPPRPRKTKPAATAPAATTATTAATTSQPSLDFSPEEVFIFMDMMGFIQSPCEKWEDTSVVSTDVLHLLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WQ85</accession>
    <name>A0A6G0WQ85_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_012821</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000163">
        <property type="protein sequence ID" value="KAF0729553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013053"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000001">
        <property type="entry name" value="zinc finger CCCH domain-containing protein 15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045877">
        <property type="entry name" value="ZFP36-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547">
        <property type="entry name" value="CCCH ZINC FINGER/TIS11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="2155"/>
            <end position="2183"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="2155"/>
            <end position="2183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2124"/>
            <end position="2148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2357"/>
            <end position="2394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2422"/>
            <end position="2495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2508"/>
            <end position="2527"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1566"/>
            <end position="1625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2357"/>
            <end position="2367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="2384"/>
            <end position="2394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2446"/>
            <end position="2474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="2478"/>
            <end position="2495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0729553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="2527" mass="282103" checksum="12807DBA159D8805" modified="2020-08-12" version="1">MEAANRIEAYEEDVLRTAASVIECISIRGRVDLVQLIQSAQHKPIAWIDDVVCTLESSGKVARVVVDAVEGWVLAPVGEGSSREERLPELGPLYASILCQRAAIHSRQTLATHVDIYASADPALQSWWLESDKERCIEVLETNLHTLNLLLETSSPESYVWSMKSSQNQWMLGLGAVFPCEDELVEYLAQDPLRSHGATTREGFSSLLQAYRLSLSPSSSFRHWWISSLEAPASVILREFIRRGILQLGPQDGALEWNVLSLIEQAFKIQSPQAERCSKPGWTLERVNMLREIAIDAFRAQAIQYTPSHCNFQVAAAETNGNVLQERAPTSRQSILNGILDNMTQKTELILAQDSNSYSILQFAQRKEDHACNESTHQVEEAILDPPRYEVVDIDRDIHQMKTNSDSDMVIIPDNLKRYVEKAEAIVSIVLDRIGRFPLSKMTKWINKLIKKQCLAISPDSFLNLVVAAVKPFAIVVQSDPVMFVKHAEIPSRSRFLADADTKQWSEQYIKSAHKKINKARSRLRTACESASVEKITKAIKAALNNPFHSELADDIADARNVINNLNHIEHRANDSITIKGPEPWENLSTIRNEKDVSDMASISEHEIIPSSEVALVLDGLEQNIQNCVAIVAIVLNKLGLFPLSKMMKWIKKLKPDQVDGKSPESILNIVTTAVKPFAKVSAGPIPMFLKDLENTMLVIPEVDKAANEFAQHYIQTAEINIETSRLKLRDACLEENEEKIGKVMKRIFFSPHLSKLAKEIRDARKILRDLKLKNSLVQGAETSYTSQSSVKQLVASQMNDPSDSTACNDPEVSIQATVVQAPLERCTSFALQLLKTDMYCYVADIEREITTSPLEGIPRNAYVAHIIACMKQNTRLKYAMDPNGRPAFVLSGKNWKIETRARVDNSKEGSNPPIQEATVGLAHSEKNDSSVVITCGPMNLDHSIQNCVAIIAIALNGLGYLAVSKLMKWINKLTPQQRDGKSPETFLDHVVAAIKPFAKVSSDKVPLFLKKNENISLPIPNADDAAEEFAKQHILKKSEAIEKERLSLRQACLDENEKKINTVIKSLSFKPYHTKFTKEIRDARFLLNNLKLKRSQGKSVDKSILNPSFKTKLAQKILSSMKKNGPLDYNIQTCAAIVAFVVNRIGFFPVPTMLKMIKMLTPQQRGSLWPEAFLDAVVVAVKPFAKVLPGLMPLFVKQQEDDFETIPKADAASKEWAEEFIHETQKEIDKKRLKLRKACEEKNVELITKILLKIKRTPSRLVLVEEVKDAQIILKALTQDESQSNQAEVLFTPPESCCSLASPDESKDMSDIIAAIEEKNAVQAAVHKFTMRALIWLETHPHYHVADIMSQTKIRPVDGLSRDEFVARIVVHMKQDTRLKYANDPQGRPAFMLSNNEGSEYALEISPIALEDPVHPDGRPALTLSAQCSASDPEQTMDDRDHDSTPSIDELLLQNEASPLSSDATIVPDNLTPMVEICVAIVAIILDEHCYVQVSKIMKWIKQWTKMKNITVTIDEILFFVADGVKSFAALSTDKPMAFLKFAEINPAYFQNTDSAAQKYAKQCIAKMDKKIEKARLKLRQACKDEKMDAITSSLDSILQARFHAKLSDDIQHAQRILDTLEKIKSDVPDSIQPSIQNCVAVVALVLERFEFFPVPTMMKWIKSLSTKQRSGITPEAFLDAVVIAAKPYARLSSGVPQLFVKPRESSSLTIPKANADSHKWANKYILRSTMWIDKTRSKLQRACEEENEESITKMVHKIVRTPYRDILKEETAAARKILKVLKERRPNADVLSALESPNCISSLDENKVISDETYANDSDTIQTSVEKFTLIALDWLSNNHYYYLTDIERQIKTSPVEGISTEQFAARVVDQMKLDKRLNYGLDPKRMPVFTLASGATQSALEKSSVQLELEVKEKSSVQLELEVQAAVEKYTGLALMWLATNAICGVETIEAEITSSPVEGLTRKEFIAEVLSGMKLDERLIFVTSPNGNQVFLFFCPDKRTVSPNTSRSEYENAVEAAEPNNAVETAIQAQVTKFTAYALKSLGKIQYYHVANMHGQIKTSPVGGMTKEDFIACVVDRMKLDTQFNYTTDPRGNPAFTLASCGSTESSLVEISTSCQVSTSELSSEHSETISNSSYQSSNKTKERHQKVNRLYKTVICTRWRDGGTCYVGDKCQFAHGEAELRSNHEDTPRDIQSDENPNRLGVADILLDSEERIVCHSTEVPNSSVGSANMAAYFQSVMQEESIIKEAMKAFEAEAMKALETKSYVFVDDVFNAAGINLPSGMTKDAFLDKLEESLHYTLKVNWNTYEVYGQPSIVRVGKTAQQDLPLHQMTASVVAPRLGGQKRQLLFEERDEMSGSEHGDGSSDDADDNSSENGFDSGESDQSSDDELGNEMHLAEEDIPENFLGIDDSNLRSQEVHDDFHSPQDDNDTADNDAGGADTDISRDEADDDLNRAEDGNSSKSLQDDDLKVSPCQVQQGEEAHSNAQPANESITQVKVDAPSDFTDVIEPSNKEIGKQKCILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WQX2</accession>
    <name>A0A6G0WQX2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_012673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000161">
        <property type="protein sequence ID" value="KAF0729782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WQX2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014289"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF57">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="1">
        <location>
            <begin position="73"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0729782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="224" mass="25720" checksum="A315EB0FEA8093B0" modified="2020-08-12" version="1">MRCQTRCGNKSSEEGDATLKAFSDKILKLVEENEIEEIYNADQTAINYEYLGRKTVNAVGEKRVWIRTSGHEKQRATAMLLANSKGEIFFLFIVLKTTKCSVEKNVQENIDQRNGFGKVVWKEICKIQDKFTAQLYGNPTAWWNSAISCEFINYHFGNRKGKNVKPILLIWDDFAPHFCPKVIGLAASLNVMLEKVPPGFAWMCQPADVAWIKPFKTMMRKNWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WR88</accession>
    <name>A0A6G0WR88_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_012554</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000159">
        <property type="protein sequence ID" value="KAF0729915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WR88"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001662"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0729915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="293" mass="33596" checksum="816ECF719D3D0319" modified="2020-08-12" version="1">MARPKSMLWRQQFMRLLACVAAMFVMLIEFKGSQANMRFLFGEITPTKESSIYQCTYVPRLLPAMVPDSLDRELMATLFDSTSSSNMVYLDSDMEAEQLVSQNNSCSMPTANDYLYDSFYLNTILNAAFAGYGGWNASDSWIIVDCSFENRLIEDTTMIKFFLLDKAQTKITTFVLQTITVSRPRTHEKLSSGLATWTHTTLKSLKLTNEGDVTWTEAAEYFVEVGFEFPFEENDFVPVELESLVPRGETWIGRLDTMKEEFEFVATSGMFRRSPTIQAYMDVFYWDLPPNPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WRF0</accession>
    <name>A0A6G0WRF0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_012442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000157">
        <property type="protein sequence ID" value="KAF0730044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WRF0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014947"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0730044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="125" mass="14251" checksum="0B9F5F3FE9C25C10" modified="2020-08-12" version="1">MMAYGLLKRADRSKVFINSLHPGIVSSDLVKSGVKLPQLPRIIRPALEWFTGFFFRSFGYTPLKGALTHLYVASSPDIVKNEWQGQYFSPIAKLGKSSDLSRDPEQIKRLWKWTNDLIARILGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WTG8</accession>
    <name>A0A6G0WTG8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_011849</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000151">
        <property type="protein sequence ID" value="KAF0730738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WTG8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016508"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0730738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="163" mass="18441" checksum="5BAA5C4D351EF7AE" modified="2020-08-12" version="1">MTTTPTLQRLLTVRQSSFGDMECSIQGTSLRKCQKSRLGLPEVVFQVRVTIVNRRGWTFHSTLRDVARLHSRLLATVQDNEFTDQLGSLVCPTQPWFGRKNAAVIKGMCCDLDHYLSNLLRICQRFILKATRDEAIAVESTIRSFLNPSTISPMDAKSKDKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WTP7</accession>
    <name>A0A6G0WTP7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_011811</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000150">
        <property type="protein sequence ID" value="KAF0730809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WTP7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016225"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0730809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="250" mass="27164" checksum="5AACEA849EF6E6D5" modified="2020-08-12" version="1">MLRNVLVMATSGLVLFSKEFLHAIPQPRLIGSLLTAILEFSAKTTGAPVSYMEFTNVAVTIVVNESAKVFCAIFFDVADGPKFGAFLAKEILAAFVDEYAGDLGNIGHNLRDFHGFHYKISEVIRESVKPILSTLQQQRGIQKAILVTDDAVTYATVEVDQLGVLVNMQSLRTLAADTMAFVGDNAHSITILGARNSSIQVRAIENATLVVSFKQGGPYTAVCIAAINEAIFMLQRVCLLLKHLHQTAVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WUC6</accession>
    <name>A0A6G0WUC6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_011652</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the histone H2B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000147">
        <property type="protein sequence ID" value="KAF0731109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WUC6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000607"/>
    <dbReference type="OrthoDB" id="71614at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000016">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="12">
        <location>
            <begin position="14"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0731109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="118" mass="13125" checksum="4C61A387C977CCC2" modified="2020-08-12" version="1">MAKTPSKKSAKAPKKTGDKKNRKVKRTESYSTYIYKVLKQVHPETGISKRGMSIMNSFINDIFERIASEAGKLSRYNKKSTLSSREIQTAVRLMLPGELAKHAVSEGTKAVTKFTSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WUV7</accession>
    <name>A0A6G0WUV7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNI-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_011390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000144">
        <property type="protein sequence ID" value="KAF0731327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WUV7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013694"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0731327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="428" mass="49042" checksum="7B3D4800CF210CD5" modified="2020-08-12" version="1">MSIEKKKHKTVLKWAFPEHVLVNIGFCISHHADLFAFELGLTRDYNLLWPYLVLTSRIICSSQRSTYEAIAKFYRHIHVYVFMDIEWLKSFVDPKAELSWKLESLPGILIRNSNYWSEWADLRICHLYVDCDVPSGWIDVLPRLQYLKTLILKTLDDTHVDTILEFAAMSDQLTELVISTSESGILTDPMLHNIIAWSSRQPVRVFAIFSWEWRINNMELKRSFYQATFNCPTLKDLKIAMMDLSDMDLTNATLSMQTLQIRTCFVPPNFCETLAARLIDSNVVDLSLVYTSNTTLKGIESLLRVLPKTSIKSLDLVDSTVSSADICEFAPQLQATTLKTLKIRYAELHEQAVSSLANAIQNNESIAELDITGTVMTSQDCHRLIESATYTSRPIEMKWIVFQESNLDQHDLKALSAYATERGIQFDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WUW9</accession>
    <name>A0A6G0WUW9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_011520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000146">
        <property type="protein sequence ID" value="KAF0731260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WUW9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017104"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0731260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="19038" checksum="3F150D3D4802C61F" modified="2020-08-12" version="1">MQSTHTICPTLEHLYHVPIDKNTFYVRMKFGIPNSTKKTESGVILKRQQLGPRTIRMAFRSIANDEGDPFEADSFVCNQYAWAHIEETDDGSFLYKSFMRVNTKVFQPADMSSLANMAELVAVDHAWKTQAPLDTMTISTTLFEAAFRAFQANLKEQLANYQVVECE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WVN3</accession>
    <name>A0A6G0WVN3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor ISY1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_011163</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ISY1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000141">
        <property type="protein sequence ID" value="KAF0731538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WVN3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011668"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.660:FF:000001">
        <property type="entry name" value="pre-mRNA-splicing factor ISY1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009360">
        <property type="entry name" value="Isy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037200">
        <property type="entry name" value="Isy1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13021">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ISY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06246">
        <property type="entry name" value="Isy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140102">
        <property type="entry name" value="ISY1 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="141"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0731538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="23716" checksum="AC926FB411FA550A" modified="2020-08-12" version="1">MARNEEKANSMMNRWTALKQDMAKIFVGKRPLLTSECNNLADAEQYRLQVIRIISRKVSEIQNASLGEHVIRDLNDEINKRIQEKLRWEKRIIELGGITHTAGPSGDDGYEADGSALIRGNGYKYFGAAKNLPGVRELFEKQDAPPPKRSRKDMYQGIEPDYYGHRDDDDGELEREEAAMQAKRIQAAIQAWDEREAEKARAQAQTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WWA3</accession>
    <name>A0A6G0WWA3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Protoporphyrinogen oxidase</fullName>
            <ecNumber evidence="4 11">1.3.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_011071</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>protoporphyrinogen IX + 3 O2 = protoporphyrin IX + 3 H2O2</text>
            <dbReference type="Rhea" id="RHEA:25576"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:57307"/>
            <dbReference type="EC" id="1.3.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrin-IX from protoporphyrinogen-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Protoporphyrinogen oxidase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.4" evidence="4 11"/>
    <dbReference type="EMBL" id="VJMJ01000140">
        <property type="protein sequence ID" value="KAF0731769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WWA3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003072"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00324"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004729">
        <property type="term" value="F:oxygen-dependent protoporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004572">
        <property type="entry name" value="Protoporphyrinogen_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00562">
        <property type="entry name" value="proto_IX_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF3">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 11" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 11" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="12">
        <location>
            <begin position="11"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0731769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="470" mass="51406" checksum="146EA361623D5670" modified="2020-08-12" version="1">MKSIVVLGGGISGLSVVHQLRKRIPSNVRIQLLEANSLLGGWIKTNRNDFLFEGGPRGFRPSRNGAEMLHLVEELGLEKECITSAGTNRFIFTHGKIQKAPTSFLEFLQWPLAFDVAKAVLREPFVARTTASDESIYDFISRRFSPVIAERLLDPMTSGIYGGSIRYLSMRSCFGLLWDLEHAHGSILRAMLFHPSKKSTTLLDGTPHSRFVEETSKAMSVSFRDGMQTLTDALAARIETMPHTSTHVNTSVRSVAGTPSGQVVVRTNAEEEFVADHVFSALPAHHLASVLDSPAVVNHLRKIHFASLGVVTLGFDRDIVPAPGFGYLVPTCEKQPVLGVIYDSSSFPEQNPAGRSVARLSVFMGGENHPNIASLSSSAREALAIETIQRHLGVSDMPSHVESAWLSESIAQYPVGFHNLLASIEQDLARDIPAMTLIGNSFYGVGLSDTVYRSTVAALDFAARHFPSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WWL6</accession>
    <name>A0A6G0WWL6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_010909</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000138">
        <property type="protein sequence ID" value="KAF0731958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WWL6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006411"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="142"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="962"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="306"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="599"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="962"/>
            <end position="980"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0731958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1000" mass="113784" checksum="E7D24B82F4F3802E" modified="2020-08-12" version="1">MQSKINNKPKTTTLLGIQIDRKEPAARGKVHRTTLVRKTPSSPDFNDILPKTIVDFTEDPNEKKRENPSLHAIHREFNAENATTESTSATASNQDESNDIPRPHKTISFKPILKARLAKIATIRGLSESKKANNARHISWQEENTDANFSSDEPATSSEASDTSSERQSSDDVEDIFSGITLNFMDELKHEVQDSQIFRDLNREFDMAPANTLTIENSAKIDLANSIKPKVTPRRMTLQDAIKAGHVQTKQKIDQVQNAKPVRSTSIRAVEPRTKLVQERKAMAKTKLDQKCTSLATSKTKLPPLVVAKNEEIAQLKAQLAEVKADLVEAKYDLVVHAQTEKHLRELNDERLQEIDAPTQLLSQERIEFEHQREENCHLTQCVEELKEQNHNQKNYQIKYETIVVEFEEARRHWSATQTTSEERLGYYKQQLGTAQRRLGSAIHDKLECEVQIHCLQNILHQTVQENDDSPVRTACYSMEDRTPQILATARTQNAEIGHKAKLSPGLVAKDEETALPTSEPVAVQSELASTEHELCIREQNDCDLLREFNASYQKFHDLANDNRNLQTTVENLTAGYTRDGQTVNELDFIVQSGSQTQLETMQEMMQQLLQENEVLHNDKKASNNAQQALEAQLREVHSRNDILLTRCDEYESKIEGLESKLHEAQRAKQIWESKLDDDRATAMDQDIHSHGQEAMAQLKHEGATNDKHDGETQIPEAFIFVPCSSAMSQNDKEAVCEFRIPVSNAPGITSVDSIPEKESLVEQNLRLEDQVKNLTLMCKHIVERCQKNESHIADLDLQIKQIHHTTPGNIDLQFNCSQAQSKFILQNIHKIDQGRNIDKAKRLLAPDIINKVSQDRDISHPLEFETHAQPYIHDEELKCASSNVVETKSTSTDEATEDRPLTSNKVASIMDFPIPSTGLTSSQLHLRLSRMPRAPISPNEIKKIHRRVYDKLPEVIAKKQQNELRHQQQEQIQRRNESRHVRRDQHGNILPNFALKRNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WWU5</accession>
    <name>A0A6G0WWU5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proline-rich protein PRCC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_010907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000138">
        <property type="protein sequence ID" value="KAF0731956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WWU5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002638"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018800">
        <property type="entry name" value="PRCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13621">
        <property type="entry name" value="PROLINE-RICH PROTEIN PRCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13621:SF2">
        <property type="entry name" value="PROLINE-RICH PROTEIN PRCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0731956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="31792" checksum="2CE16FA64EB3BFF8" modified="2020-08-12" version="1">MSLVADYASDSDSDGPTPVTVPKTVAEPTPVIFHPPSLPSVSEKKPVAPKPPKKKKKVLHLPPEIQKLLESGRTLNSDDESDDEKAPVKRKAVTKAKNEAPADLLSFLPPPKVALKVLPATQAPPKTHTATLAEPQDISTDSEPPQTAQDNFVSNYSFDDEHAAEDYGQGKRRRNNERELERLLQQGQFDAVAGKITEVQAVAPDAWQRPIDARGYSHDKEAQVLASMAGTETEAGYVISSYRPTRLQRQRHQLNQLTFDAKVRELDLLDSRATMARSKKETAAKYAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WY64</accession>
    <name>A0A6G0WY64_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Multidrug resistance-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_010474</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000132">
        <property type="protein sequence ID" value="KAF0732485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017219"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000063">
        <property type="entry name" value="Multidrug resistance protein ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000610">
        <property type="entry name" value="Multidrug resistance-associated ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000997">
        <property type="entry name" value="Multidrug resistance-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="89"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="713"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="769"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="852"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="958"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="981"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="90"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="413"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="725"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1043"/>
            <end position="1277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0732485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1290" mass="142705" checksum="789D5DA771A329E4" modified="2020-08-12" version="1">MRDKLYNTFGPVGGGAHPLDTASIWSKIGFSWAEPLIALGNQRQLSPDDLWSLQSTNNVAKLTSTFSGAFKSHSQGVIRAFFAVYLWKYLWLGLLQLFTAVCDLYGPGFVLGQIIATLEAPTFDTEYVLKLVGSLFVVMTASALVKAHVAFLNDILGIQFTASLRSMVFTKALKLSAKSRKEKSAGDIANLFGTDVLNMMEFANYSHQLWIVPVQILIVLGLLYRLVGWASLVGLAIVGLVLWINSRSAIALGKAEMQLLKRKDDRTKLLTELFGAIQIVKFNAWEEKFGERAQGLRDLEVGALRVFYKYLILIQSLLGCTPVLVALSVFATFTLGMKQVLTVTVVFSTVALFKSLQEAIESLPVSITTFMQSLVSAKRLNAMLVMEVVDQTKVQTPANIDKSHEYAEEHVVVAIEDGSFGWDADNLLFRNINLKVHQGELVVIHGAVGQGKSSLCSILLGEMVKTNGSVFVGGQVAYFSQQPWIQNTTIRENILFGKPYDRTKYDKVIDACALAKDMASFPAGDRTEIGAKGLNLSGGQKARVSLARACYSDADVFILDSPLSAVDAIVSSEIFRKCFQGLLHHKTVLLVTHNPEIIASPEVAKAYLIQDGQITESTRSPTTLSPVAEEKSPLVSPLRQRRPYWEASYTEAPVVVRKHDSLLTPTASTPYNFKPVEMLFTPRGKDVNESHGRLVKEEVRAVGRVSKAVVFKYLECIGGWPAITVLLLVTVGMQAFKITSDLWLTKWSNDTNHMDPAVFVASVNYNMSVYGSLALGCCVFTAIGCACVFIFSVRGANKLFSAMLASLLEAPMRFFDTNPIGRLLNRFGDDVTSCDLNIPFGVMNMLFEASSALLTIGTTLVLTQWLGIFILPLMYIYIRIGAYFLEPLREVNRIQKTTRSPLISLVSEGIDGSTTIRAFGDKQRRRFQRFHDQELEVFCATRFANSSINQWFSLRIELLSDSIVAVLLLAVVVLHDTLSPGLVGLLITYGLTIPSNLAFLVNIWSRLETSMISPERILEYINVEHEGHRDGSPQQQWPTVGRVVFDNVSFRYKPNDPLVLKNVSFDVQGGEKIGIVGRTGAGKSSLMMALFRINEVASGRIQIDGMDTATIGLKTLRNSLAIIPQNPVLFKGTLRNYLDPFDEYSDEQLWSALRKVKLMDRLSTVEEKLLGPVEENGDNFSVGERQMLCMARALLRQAKIVVLDEATAAIDHATDQLLQAVIRDEFASSTVLTIAHRLDTVLDNDRVMVFDHGELVQCDKPSILVAQGSGIFFELVSEGGYMDKMTRTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WYI4</accession>
    <name>A0A6G0WYI4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Conserved oligomeric Golgi complex subunit 6</fullName>
            <shortName evidence="9">COG complex subunit 6</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Component of oligomeric Golgi complex 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_010297</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Required for normal Golgi function.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the conserved oligomeric Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Golgi apparatus membrane</location>
            <topology evidence="1 9">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the COG6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000130">
        <property type="protein sequence ID" value="KAF0732589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WYI4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021421"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010490">
        <property type="entry name" value="COG6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048369">
        <property type="entry name" value="COG6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048368">
        <property type="entry name" value="COG6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506">
        <property type="entry name" value="COMPONENT OF OLIGOMERIC GOLGI COMPLEX 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20653">
        <property type="entry name" value="COG6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06419">
        <property type="entry name" value="COG6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01087">
        <property type="entry name" value="COG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric complex COG6 N-terminal" evidence="11">
        <location>
            <begin position="44"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved Oligomeric Golgi complex subunit 6 C-terminal" evidence="12">
        <location>
            <begin position="189"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0732589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="634" mass="70635" checksum="E14B199704F7A07F" modified="2020-08-12" version="1">MSTLLQHRVKKLLARESELSHAKSLLDTIPSLVSLNSSGLSSVSSASLRLSLKSKLDHASRSVAESVLSDMESLLSALDELKMQADSMDRKCRHVLTYLESTEKTSNAFSSQAAALRAEKQAIQAELDATREFLDKYQVSSDDMTLLQGTGPLVETDSVVAFFQLVHRVQTIRTNCQTLVESNPSSSHLELLDNICLAQNLSFDKLYQWANIQCNRELDDDNTDSSGGVVEPSRLLPQAMRFLRDKPDFYNHCKETLLATHRTGLLRRFMQALSRGGANGIPRPIEIHAHDPLRYASEMLAWVHQTSISEQEYIKLFFDGDKKDDKDDDLHRILGVACAGLTRPLHIRLQQVVTSSGLLVVFGLVHVLAYYTSILSPLMPDSDLSLALIECSKMAESTFQQQWHAQLQSYQDALKVSLDFSLAVAHPTLDLTYKMGHLLESYLDSLLPNGIDRTQVAKVLDPMVDAVLAPTILKQSTLSRAETNVFLLNQLACVDATLRRFQDIAQVWLDKLQLAMTTAVDAIAASQAEAIQQKCNVIRLVESMKSPDTAQSLEADFVRGIVHDYCTQLLALQLPLLERISPPDWRHQAETRTASYLCTVYDEIHAYVAARSSVYPSGTIVHSPQEVRTILDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WYL7</accession>
    <name>A0A6G0WYL7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycoside hydrolase family 6 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_010312</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000130">
        <property type="protein sequence ID" value="KAF0732604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WYL7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004484"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.40">
        <property type="entry name" value="1, 4-beta cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016288">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036434">
        <property type="entry name" value="Beta_cellobiohydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34876">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34876:SF4">
        <property type="entry name" value="1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01341">
        <property type="entry name" value="Glyco_hydro_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001100">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00733">
        <property type="entry name" value="GLHYDRLASE6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51989">
        <property type="entry name" value="Glycosyl hydrolases family 6, cellulases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026073275" description="Glycoside hydrolase family 6 protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR001100-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001100-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0732604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="33361" checksum="3A345CB669A6A385" modified="2020-08-12" version="1">MKVSIVSSALSLAALAYTAPGANLCNAVVPKSYVNAANQFPDLRSAIQTVSANPIATWYTDLGTNQVAQTLAACTNAIPTIVVYGLPNKDCSGGFSNSGNNKNTQQYSAWVQTLVKQVGNKEVICILEPDAVGLVTNGSCGVTNGYQNNLKVALGLLSTNPNAHIYVDVASWASQSAAVHPQRLEEGWSSPRHCHQHVQHRATSQLNSLCQTYSSATGGLHCVFDTYRNFNGASSSEWCNARLAGMGVPPTSNTGNPLVDHFLWIKVPGESDGQCTGQSADAMIGPAAGSFFHDGFKTLWNQGFYVKQLSMAMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WYN7</accession>
    <name>A0A6G0WYN7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CBM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_010332</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000130">
        <property type="protein sequence ID" value="KAF0732624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WYN7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005987"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026144439" description="CBM1 domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="3">
        <location>
            <begin position="22"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="3">
        <location>
            <begin position="86"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="3">
        <location>
            <begin position="189"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="3">
        <location>
            <begin position="244"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0732624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="282" mass="29026" checksum="ACE42DB8221A7729" modified="2020-08-12" version="1">MKIPSLAAAFLVYSTAHAQDTNQVAAWAQCAGNDYVGSSECVEGYECQETDVGYSQCVEVAQASRGSLRGYSAASSSDNNSVEGVQLVAAWAQCAGTDYVGSSECVEGYECQETDVGFSQCIKVDTVVASNEYTDSTADGASTEGFQINSDAGASTKGFQINSAAGVSTEGFQINSAEGTEPASADGVQLAAAWAQCAGTDFTGPSTCVEGYECQETDVGYSQCVEVAATSDSTESSNAVEGVQLAGAWERCGGDDFVGPTSCVEGFVCKEIDIGSSHCVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WZF3</accession>
    <name>A0A6G0WZF3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Organic hydroperoxide resistance protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_010208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OsmC/Ohr family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000128">
        <property type="protein sequence ID" value="KAF0732884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WZF3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001930"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019953">
        <property type="entry name" value="OHR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03561">
        <property type="entry name" value="organ_hyd_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33797">
        <property type="entry name" value="ORGANIC HYDROPEROXIDE RESISTANCE PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33797:SF2">
        <property type="entry name" value="ORGANIC HYDROPEROXIDE RESISTANCE PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="OsmC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0732884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="158" mass="16462" checksum="0E266DEF53544AD4" modified="2020-08-12" version="1">MFQRVLPVARRATLNTTASRGMATTVLEKVVYTAHVTTTGGREGHSKSTDGGKLDLQLGAAALNPEQLFAAGYSACFIGALKHVAGKEKVTLPEGLKVDASIDLGPIPTGFGIAAKLVVHLPGLDKSAAQKLVDAADIVCPYSNAIRGNIVKELVVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WZH5</accession>
    <name>A0A6G0WZH5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_010038</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000127">
        <property type="protein sequence ID" value="KAF0732929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WZH5"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0732929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="110" mass="12501" checksum="7950C8560C23F854" modified="2020-08-12" version="1">MLHCSCVYSLSSSVVGKLPVAWELENFRGKIGLQDLLYWSSCREKFLVHVELIKPLVMTRREDNNSFGSHSVLKLDIMSASSQDHSIVGRRERERLERTAADSMFPAVTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WZL7</accession>
    <name>A0A6G0WZL7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LYC1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_009845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000126">
        <property type="protein sequence ID" value="KAF0733018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WZL7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001769"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055100">
        <property type="entry name" value="GNAT_LYC1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053013">
        <property type="entry name" value="LAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34815">
        <property type="entry name" value="LYSINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34815:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13527">
        <property type="entry name" value="Acetyltransf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22998">
        <property type="entry name" value="GNAT_LYC1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LYC1 C-terminal" evidence="1">
        <location>
            <begin position="166"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0733018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="331" mass="37379" checksum="A6322D7C70830FD2" modified="2020-08-12" version="1">MSWILVPSSPAQQLEADKHAHSTWGAPQLTLEQFLTRERELSASDFAKETLTSYVLVPESEPDTLDILCYVEIFKRPCLYGGKIVTSYSIGSVYTPAQHRKKGYASLLLQHVDKIIQAQDGSIVSNLYSDIGPTFYAAKGWTVHSSDELVFPLSLSLPPPSTDVYLRPIDSKEILAQVCRDDLAHMQALSTPSTVYFVLTPSCVEWFQVRSHFYARTLAGLPHVPKSVGIVATNDQNPLTNYMLWTHDYKYNILMILRCRVEEAAFPAFINAAVAEAKQWSLETVCIWNPAPWMAQAYAAYLEKRTDSLPSLKIHPEKEVTWLANEKYCWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X100</accession>
    <name>A0A6G0X100_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_009761</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000122">
        <property type="protein sequence ID" value="KAF0733525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X100"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021861"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0733525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="355" mass="39485" checksum="3A897312AE7AF6C6" modified="2020-08-12" version="1">MTMAGLADEIIQGRQLFHAGRLHAAEQCWRECLKEAYAQGNHAATFVLSKNLGDVTPDHVEALQFYEYALELATTCGVLRNPSLRSVVAKIAVAMQDLESNRHTCQACQTPDQRIFRQPTAPETHLCFRCYEQQVNTDETICACATCGNGFSLQELTRDTDDELYCKPCYDAYYEEQDDDVREVENEEKEEAADPGMLCAACLDADGTVRDLNELFYCQPCFDRKNQTPVDFVANVVEPDELPTTTTVEANEVTSTTTPSVISSRSSKGPKRLVYGRAALMSLRYVLTECPSPVKKSSVYAAPTPSKAKVTASTLEPQLPPPTMTKEQFSRHVVSTHASNITTMATYFQKERLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X151</accession>
    <name>A0A6G0X151_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_009736</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000122">
        <property type="protein sequence ID" value="KAF0733498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X151"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017073"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="3">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0733498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="520" mass="57935" checksum="AF740B3004605E0C" modified="2020-08-12" version="1">MLTNVASLFNRDNTPSPLAVAAATSTVLFGTLVLQCAWKSYQLSHLPQPPTSSFLFGHMFDTFGGVATWKTSGKYPEPFLSWIEKFGGAYHVREFLEHVVVVSDPVALQHILVSNGPNYPRKQIAMDYFGDVVLGYGLLSVDGKQHDIYRKLMNPLFAVSKIKTFVEIFNSQTQLYCQNYLEPACDTHAPVNLSKMFTKLMLSIIGLTVLGYDYDKSPVALEAYEQSMIEVSPLMLIGAFAIPGFLSFPIPSLIKRRKAQNTLRNILTRIIHEKLANLASEQPKDLLDMVLPHATTQEAVSHTVTFMLAGHDTSSNTLGFVFGMLTSHPQAIAAIRAEYQKIIAHYGSISSWDAIADLEYTHAVIQETLRLNAVAFAALQRTTLANDNVPMSDGASIFIPQGTYIHINMAAMHRNSKYWSNPTKFIPERFIEGTPEWNADLELRGGKPHTFHYMPFSMGSKNCIGQRFAMAEIQLIVATLVSKYDFTPTAKTDLHQEFSGITLKPVKVEMTVRRVITPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X1T9</accession>
    <name>A0A6G0X1T9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alanine--glyoxylate transaminase</fullName>
            <ecNumber evidence="3">2.6.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_009339</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.44" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000119">
        <property type="protein sequence ID" value="KAF0733769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X1T9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009786"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008453">
        <property type="term" value="F:alanine-glyoxylate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004760">
        <property type="term" value="F:L-serine-pyruvate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019265">
        <property type="term" value="P:glycine biosynthetic process, by transamination of glyoxylate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024169">
        <property type="entry name" value="SP_NH2Trfase/AEP_transaminase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21152:SF24">
        <property type="entry name" value="ALANINE--GLYOXYLATE AMINOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21152">
        <property type="entry name" value="AMINOTRANSFERASE CLASS V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000524">
        <property type="entry name" value="SPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="9">
        <location>
            <begin position="61"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000524-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000524-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0733769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="366" mass="39008" checksum="8E0709B07831B1CB" modified="2020-08-12" version="1">MSTSMLRMVPGPTTMSEQVRQVYAQDIGSPDVELEDFAADYFALEDLLKRLLSFEGSIAIGSGEGMACLWGAMKSVLAPGDVVLSVANGLYGEGFADMAKGLGATVITVASDWTTNVNPQTVIDAIKEHNPRLVTMVHCETPTGVLNSLEGIGQAVRNDTTDGLFLVDFVSSSFAAPLNVSAECIDIGLLAPQKALSGPAALAGTTVSDRAWKRILEVAYKGYDALAPFHGLNRSTPFYMPYTHNWPAIRATLQACRELESEGLDNVIRRHAEASRECHALALAAGLSLYCNPEVASPTVTAIHVPAHVSWDAFVQELKREGLICGGNYGALAGKVFRIGHMGNQAQVALVRDAMAAVARTLKTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X1W9</accession>
    <name>A0A6G0X1W9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_009336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000119">
        <property type="protein sequence ID" value="KAF0733766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X1W9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000579"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0733766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="229" mass="25811" checksum="A8D9935E85253623" modified="2020-08-12" version="1">MLAELSGPIPMADAADGKRRKKFSLKRWVKKLVAKRRRALEETQLKRKQRKDLKKKAKSSDDRSMDGLVERFNQLPISIPSKCDNNQDDDSAIEPTIAPSRKESVALRIGVPYTEAITIKNPIFEGLDDEPNQSQRKTPLLRAEAPEDTSRGGNVRFDLFSQINKLPENPMDFLREPKKNRALKPRLIHALTKPQPQFTGPIAQVLAQAALALDGDDSSDEDSSDDEWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X3Z9</accession>
    <name>A0A6G0X3Z9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_008797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000111">
        <property type="protein sequence ID" value="KAF0734555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X3Z9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000548"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0734555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="478" mass="54451" checksum="D4FFD79E7CA5B832" modified="2020-08-12" version="1">MATTEVPTTLVSGRAQPTVELNEKSELLVYIVFGLSFYAPIALVLYSWNRHKPAIRYRNPREMGFTAASMILFINAKCVTTLYGDEIPCTILTLFTGLPLQFAFIGFLLAKLRLVLTFRLTELTVAYTENKGVHSRSLKRLRAFLSPRASAIAWIVTTILWNTPFIILVTIQSNKLDYCPSGQGREVLICYSTEFCILFLLSIILSCHLSHDLDNFNIGGSFRTSSRVIAFLFCFTMPALYYSDTDVVQEYALDLYACLLTAHAFLWIHIVQPVWRSMDYDPAHDAQVLHGTAAVLDAYLHTPEGFDTFCEFAKLEFMYECVVAWKAIVAYRLDTEDHMTTYEIYEQHLVEHAPLSVQSALPESVWKRYQIAFASTSKYTIRPEEIHNDSTYYDVLFDAITAKLLRETLPHFQNHTLGAKWTHFVMAYRATVALNQVLDDVPSEFDSSVKRGIYIGTTKRMLPIQSEESMVEISEGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X4K3</accession>
    <name>A0A6G0X4K3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_008640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000106">
        <property type="protein sequence ID" value="KAF0734792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X4K3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001504"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097149">
        <property type="term" value="C:centralspindlin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051256">
        <property type="term" value="P:mitotic spindle midzone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46199">
        <property type="entry name" value="RAC GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46199:SF3">
        <property type="entry name" value="RAC GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="23"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="548"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0734792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="770" mass="86198" checksum="211F543BBC168154" modified="2020-08-12" version="1">MKKVLRKTSALLRATKRENPSYDVLDKMSVPASQLLIELLRYVDLECMDEEGLYQRNGPPLQVEELNAAFHHNLSTAAAFPDLRMYNPHAITSTIKNILQEYQPLVPYGVSKTLVELVDEVKVTPEVIAEHFVKIPATNRDTLRVLLRHLKQISEAKILRMDVSSLAQCVGILLVRPSRDKQANNIRSTLKSRQKIARKLIRGAESWPYDCATELDVESIPDAKGAQYGMKLAWNSERVQYTEAQLRSILAPYGSLVEVAMHPTDTKARASIHLKHSIVLDKFVVALQKTTELRILHLQVLSEHNVDELIGETNSSLQKFHGLSTAVPNSVPEDAIVVQDVLSGAEDEDVRPVAEQVEAPNFTAPMELPLVEKITSSQDLLVPPKTSQCSKTLPIEHEKITIATQTTTFAVSRLGEDQETQTPRLECEERTTQTADDFTIEIQLNRVIQVLKTTTSSAASSSDETVRAMHQAQLQVLRMLEAMTTKGGQPDVFDTEYSAALAAHTRAKTKLLEAEVLAAQELLRMNKAQFEKQTEAWEVDMTSLRMIAAEAEKQSMEMRQQLRQVRMRSKQKLLEAEANQSLLEKEVESNKLELIKLQDVAAKAQLRVEAMKATPVPVEEPCETEQRRKPTSSLDHLTQIKLNMSDRLQVQIEQTKAAINAMNQQDATSLHLAHQQETLETLMTTLADDQTRRIKASDKALEASRLMLKQLYDPSNPITSSPSIPPPVWINPVVNEYSAKAGPRLSKSNPDSLHAARLSLHKFHQVIGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X5E2</accession>
    <name>A0A6G0X5E2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_008407</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000101">
        <property type="protein sequence ID" value="KAF0735198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012179"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005221">
        <property type="term" value="F:intracellularly cyclic nucleotide-activated monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005267">
        <property type="term" value="F:potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.630">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050866">
        <property type="entry name" value="CNG_cation_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638:SF11">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="497"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="533"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="580"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="643"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="727"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1023"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1053"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1168"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1256"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1572"/>
            <end position="1591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1611"/>
            <end position="1631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1651"/>
            <end position="1672"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1684"/>
            <end position="1701"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1722"/>
            <end position="1747"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="318"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="1383"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="1930"/>
            <end position="2043"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1497"/>
            <end position="1522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2060"/>
            <end position="2099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1497"/>
            <end position="1511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="2066"/>
            <end position="2088"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0735198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="2099" mass="237792" checksum="95D49478411CB8EF" modified="2020-08-12" version="1">MVRVKWNGIACVLGLTAVLCNMITMPLRTLVLPTTELLDTPHPILALDYLLDAIMLAVCMVNLVCCRATYLRSSRRRWLWIEGMAFVPLDLAAHGMGFRGNFGLFRLNHILGIVPMLRYLRITEGHFWRMSVQKRRTMYILTILPMCSHWFACIWFYTAYVERFQEFSWDKQAMYPEFYNTTTAVAYLRSIYWSATMLTTVGFGDVTAVTRLETLIAIVVIYMGVFISCASIACVLKLMEHADRNQMALQERLDDVCGYLEWRGASNDLVDRAVAAVHANFVPQIEATQEALETMLPHALRARLQIELEQVLVHTVPRFQTASKTLRAAISEHAIYVSKGPGDVLIHDGQRLDGLYLLRRGEANCVRGADGTVLKPFNELEFIGDEALLRTDELALHSIVCVTACEFVFLARVHFQDMWQVELDRHPDLPVDDDNARRSTSRDGKDHILAVHRHGQPDDDDTASRTNSAQRMQRRRRGCWCCVMSSDWLPNSMFRRLWTLVCFSGLLYNIYAVPRDCAFFRTHNRFEDPDVEAVVDLALFWSLDVVFLVDFFLHCRRFYIEYDGHLITDRRKIFRRYVRSIWFAVDLLSILPLDLGAAWYSMTNLPFLRLNKIVRILHLSEYFQVAEALLLSRFHVHVFARRIVRIVSILVLSGYLVGCFWYYVAEVTVDDYPTANWVAVDQADPNFYFQAYVHNRFYLIRSMYFGYIGGSTLGFGDIVPVNPYETLVATIMLLYGAILKPALVGGVASLLLTRNKTRLTYQKTLVGFQTLVTAAKLPDAIKHSVARYLEFTFEHEYYAKERAILELLPDLRGEILAMLCRSSDESAPLDSSIHDDEWSFFRVVDEDSMRAIYAAMEPQLLLPQDAIDLPDGSLAVLHTGTLFQLNLDGMTVDSVDETLPLHERTIGVDRFLGLPSASTYRAGADFCEILRLQASDVETIVTPAVWTAIRDAMEAHAARNSREHSGKSALFDEPKAAVHTTHKSNHVVPISLADFGLSKGQSMLSMKLETKSRCHPKSRFRRALNVLVGLALLYNAFLVPFRLAFFSSRQPPSYLYGFLVDYVLDVLFIADVVVNYRYRLLRLTTGSAAASWQAHKSICRELKWDIVCAFPIELFVVDFVARHPDLLVGVLTVCRLPKVVRLSYFTKRVKALAQAAIRKWPHAADFVVVCRYLLFILFFSHVLACGWHYLAFADKGIFPWSTECNALDNTVAEATEATQEASCLFAGTWIEFQIHGMYLPPDGGTIWQRYSRCFNFAIQMLLVVSSGVIVPVNMIETFFCIGAIFSGIFFSAGKIGVIGEVALKVDAVSASIRQATDALSKYVAFHDVPQLLQDKALGFMDFLYRHRRTLRFQQDDVVAHLPPQLQDAIVVHCKLARLHQSELFASLPLDVLHAIAVHMKPRWYAPGDVLVHQLHYGRCMYFVKPGCVQFQDVAIATAHSKRLAVFGARSLLLDEPHPRTIVACTFAEAYLLHGLDAVFGQFPELKAQLEAQLEADDNGNETPLDGDDMDKDDCGGGQQHRLEKMDSDAGLLNRRSTRLTSTESEQDDDLMDNNAIQAWTLPNSRFRRVWDMLLFFTTVYVLVMLPLRAAYLVEDRVGVWHELVAWYTGDVVAVVLYEVDTALSFSCFAYVDHSKLVRDRVKIQENYRAYLWLDVTSIVAPFGLLLACVAAVSRSGDGGGGGSSSWTLVSALKFCMLPMLLRAKRFPRYLRRLTRTFQHASWSRLSGSMMHIVQCILYYLIMVHWWACIWMALHRYIETDSALTWAVRDPYMGGGKLSVYNATTHAHNICTDMVDCYIRAYYFVITFIGTVGLGDIRTGGHLEYFFENIEALCGSFFFAALTSCFASYFDYADTYGRGAVQAKLSTLASYFRVAHTTKPTSRAILANTKLWCSRTGGLVDAAVTAHLPVAVRVELATFIQRQLLETSRVLTTECDPFLRDKIVLCLHFQVVCSGGKIYDVGENLDEVAFVHDGMVKLIDENGTLLRTGSVGCHVGRGEAGPCLHTVVAVEHVELYVLDTNAKQEVLGHMASVQRMAFLQLLDQMSLHAMDETKLRRDATRRRASELIEEEEVELQDDKDGDDDQEEEQLPSWLPQALFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X722</accession>
    <name>A0A6G0X722_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_007953</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000094">
        <property type="protein sequence ID" value="KAF0735635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X722"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012725"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0735635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="775" mass="88611" checksum="8221F6EC10BFF040" modified="2020-08-12" version="1">MNSEPEHPPAVTLAYFHRFVEIHGGRDAFQDLTTEDVCDRFILPFTESTKLSLVDHVSQEPDGQQFVQPTQWFVSHAWSYHFLDVLDALDNFVDENNLDQRVAFWFCAFNNNQHDIKGQIRSFEFWLGGFQGALTSSRQIVMVLSPWTNPVTLTRTWCVYEVYMSIVLNARFEIAMGKTQKMEFLQDMKSGLDQKEIFLKTLATINTQESTTTIASDRDHIFKLISDQVGFAKLDQMVLKVMQDWMVRTVKHQAEAAIDPEEKCQWHLSLGTVYNMTDNLVEAEIAFKTAADIHQESLPRSLWLGWSARHWEAYVKSRLLKPKETWEPLFKESLPMLKELLGPEHKSTLRAIRDEGESYCHFGDYATGMPLLEECFATQERVLGRDHVETLPTLLCAGMYKSRQGQLVEATQWLERAYKLHREIYGESNGETNICRGTLAVCYCRQGKYAQAEPLLLTSYDHHWRTLGPDHSNTCAALFNLSAILRFTGKYDTAEANLRFCKASYERMGETSWVMHCDRSLALVLFAQGRLDEAKEWFENVTQAYTAAVGPKHPFTQGALFDRYFLQLELPGGFTLMPETMEAFENALKASNIFHENWNGMSCHGCYTTVQGTMCTCSKCPRFAIRYCTKCMKTFQPPCGHAISSWTRVKPPARFIQEECLKLLAKQGNWDGFKQNAKEYDENCEKFNVLERIDLENLKSNQSPKRSHAMLVGLTAGALSPDVRHTDGMDGYHVMRTGLTLLTNLGAPGFRTERGEDPQSVRLFVLAPSLEHSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X7H5</accession>
    <name>A0A6G0X7H5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_007692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000091">
        <property type="protein sequence ID" value="KAF0735942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X7H5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018891"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0735942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="457" mass="52458" checksum="B343F0358807E7D9" modified="2020-08-12" version="1">MEQQAKEPIGIRRDGVLQDHLYLVANDHQFREDLAYVYEILRDDSTSSVDEDSRASNGVLSTSFSTGPSYKHATAPATAFPPRQRTTEDPRRFEVRQRQEICLLRHQVEALKAHLEYRHKRALIPPSKWQRVAKIERIEKENILRENARLKQLVHQQATFIVQMENSFRNRPCLSLNDIQSEEWQNYRLPAQKSLRVEAIHAIADRQLRRMQSTFIKAGVFDTTKYILRINFVPQPGGSALVEFVNNIVLAAPFDIMGTIAWELQSCKAPVDLPEGVSQAVEVIDDQTVYVMHEDAPRRSCANSIRKRYVEPYRHVIVQRTVQEDALMPQMNRGAVENKSSWMEITPLPEDATKSHMAFVMHFEMEEVQQNNGPLMKLMASIFDRFTTAYRPAAPGTLPIVTSTMFDTTAVPYLHFQSFAEREKLLVLAMSKHSNIAIQNYLSKTRDTSKALETTNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X7T1</accession>
    <name>A0A6G0X7T1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_007655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000090">
        <property type="protein sequence ID" value="KAF0736068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X7T1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003534"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="57"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0736068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="421" mass="47750" checksum="0B81786B45A42DE8" modified="2020-08-12" version="1">MDAGRDLSWSEGLEDIGFVIAADDALHEELTNVCGLLDDDDYVVDMNDVNCKKRPRINYQKEELLRLRRQVEELKHELKVVSESKRQCKSIWAVAARHERREIQRAKEEQEQLQTAVNERAAFIAYMKRMLGKKARYAASPPCLQELKLVAQASLRTAAIHAIADRQRRRQVHTFIQAGVLAQEEDLFRASLIVLPDSRQGVRVINHLNLPVPYRVAAQACWRATCGDLRPSAAPNASETLERIDERTIYERFRQPCRGGVTAISNTIRKYFEDDDVDMLVWRSVLEDALEPHKFKGVVDDMAGWMVCRPHPDDETKCRLTSLFQMPLEAHGVHDPRPATSYPMDAILSMLKPMSFVSTRGSIADESKVGFMDVIQKIPIPSMGTFLERGRLFEVAIKTALNAAITSFQTKSTLDCNEVCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X8I6</accession>
    <name>A0A6G0X8I6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_007386</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X8I6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018548"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12339">
        <property type="entry name" value="RRM2_SRSF1_4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF62">
        <property type="entry name" value="SERINE_ARGININE (SR)-TYPE SHUTTLING MRNA BINDING PROTEIN NPL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="4"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="115"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="74"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="185"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="88"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="193"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="225"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="262"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0736366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="279" mass="32079" checksum="88764D7BDEAD9435" modified="2020-08-12" version="1">MGGTRVYVGNLPMNVRTRELDDLFYKYGRIRDIDIKQPSRPPAYAFIEFEDHRDAEDAIRGRDGYEFDGQRLRVERTTGGGRRSGGGGDRDRDRDRDRERDSKGFGRNLMGSGKYSVTVTGLPDSCAWQDLKDFMRKIGDVIFAKVDKKGGGFVEFTNREDMLRAISKFDDTEFKTRTEASTIRVKEANYTAKKGRSRSNSPRRGRSYSRSSSRSRSRSSRRSRSRSDSRDKKDRDEDDDDEKKEKDSKNDEGKSDDEDVMKDDNKDTDMEADEASKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X8T3</accession>
    <name>A0A6G0X8T3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pyridoxal phosphate phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_007382</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X8T3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018551"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006384">
        <property type="entry name" value="HAD_hydro_PyrdxlP_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016965">
        <property type="entry name" value="Pase_PHOSPHO-typ"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01489">
        <property type="entry name" value="DKMTPPase-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01488">
        <property type="entry name" value="HAD-SF-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20889:SF12">
        <property type="entry name" value="LP01149P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20889">
        <property type="entry name" value="PHOSPHATASE, ORPHAN 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06888">
        <property type="entry name" value="Put_Phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031051">
        <property type="entry name" value="PyrdxlP_Pase_PHOSPHO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="10"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR031051-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR031051-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR031051-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0736362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="25842" checksum="8606F4005F4F6D3D" modified="2020-08-12" version="1">MTGLVIFDYDWSLINDNSDTYVFQQLQPELYTHLRQLSSSGVQWTQAVDQTLAKLTCTKEQLIDALARIPIQDGMLEAVQFAHTKGCEIVIVSDANTVFIQSMLEHHNLTSIIKQVYTNPAVFEGNVLHVSPFHASNLPPHGCPRCPPNMCKGSIVQQIKASKTYSKIIYIGDGGGDFCPCATQLSSNDVVFAREQYELLRRLQANSGDVSATVEPWSTGLDILAGFQRHIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X9N5</accession>
    <name>A0A6G0X9N5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_007063</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000088">
        <property type="protein sequence ID" value="KAF0736613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X9N5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018286"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031464">
        <property type="term" value="C:Cul4A-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14255">
        <property type="entry name" value="CEREBLON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14255:SF3">
        <property type="entry name" value="SULFITE EXPORTER TAUE_SAFE FAMILY PROTEIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="407"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="477"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="503"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0736613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="544" mass="59102" checksum="5D22FE46A5ED073F" modified="2020-08-12" version="1">MASVALLTRFKRQSMRVGLILALSSVAMLAVLAHTTHGLPLRHLTSSIACTTDVDCEVYGSKRRPHVCLENACKPQPLFPIDGYDLIGTVSAFLCVVISSGGGLGGGGLLVPLYIIVLCLSSHDAIPLSKATIFGSVLASCLLTARKKHPLVADRQLIDYEVMVMMEPMTLAGTIIGVNLNKMCPEWIITVLLVLLLSKTSQRMISKGRSTWKQEDAKDRAIMLSVVQQWMDVVHARKYSPAVVACAKKWRAAVKAPPLKSEPPQAVIKMTSFHETDTEDTDFSDDDCLIQPGAKSFDTQRGRALANLDELKAYKQSIPWSDMLVLFVAWIGLLLYSMVRGGHGTPSIIGLTCGSVAYWGLTVLAFPFFACVTSYFGFRILHRHELMRSCGMTYLPGDIQWNRRTTILYPALCTIAGIAAGLLGIGGGMVKGPLLLEIGLHPLVASATSTAMILFTSSATTFQFIVFGMLPYDYAIWYGLVGFVGGFVGQVGVSYLIRKYRKTALVMFLIAIVVCTSGIVMGVLGLLDILNNGFRGFRSLCIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X9R1</accession>
    <name>A0A6G0X9R1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_006995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000087">
        <property type="protein sequence ID" value="KAF0736839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X9R1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017778"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0736839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="212" mass="24022" checksum="E34FE7016CF742D5" modified="2020-08-12" version="1">MGQCCSKRQDVHEIDESYEDKSIPSKVTLTVETTSSHVPFVSLDRQHLHSSSSYTRQSLETNNAVTLLNQDNNHEESSSSSSSPSKDMFASSITSSKNIYTSPPSSPSKSSQGFPEDEPQVDEVRAIEHQRDTIDTARQQDEPPVPSIYIRPEDRPIESAFIREERRRLALIQEQLRQERQAAHEQWVAELQEKKKEFLPTTSASNGFMTVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XA44</accession>
    <name>A0A6G0XA44_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-L-isoaspartate(D-aspartate) O-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.77</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_006999</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.77" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000087">
        <property type="protein sequence ID" value="KAF0736843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XA44"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017782"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000682">
        <property type="entry name" value="PCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579">
        <property type="entry name" value="PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579:SF0">
        <property type="entry name" value="PROTEIN-L-ISOASPARTATE(D-ASPARTATE) O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01135">
        <property type="entry name" value="PCMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0736843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="318" mass="34411" checksum="5853C146F26381AF" modified="2020-08-12" version="1">MWIARSCRVLRPSVGQRSMSVLGGMSDDLLISMNMGHSIGGMSQSSLVDSLIKAGVLTTPRVQEAFRSLDRGHFVLQGHAPNDIYANRPLKIGTVATISTPQQHAQVIEFLADHLQPGNEAIDVGCGSGYLAAIMAKLVGPTGRVTGVDIVPSLVDLSKANVAKAKVADVITWTVASSGHDILPTNSTFDCIHIGVAVETMEQVDKLANHLKPGGGLVVPLGYAGSEQLLLKVTKDAKSGSFHKERVLNVLCQPLLNVAPEELQVPETRDEKVKRLQAVLEEWKANFIKTHQRVPSRQDMLLDEQAAKWFAEFAATRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XBL8</accession>
    <name>A0A6G0XBL8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">H15 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_006524</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone H1/H5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XBL8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000964"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00073">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005819">
        <property type="entry name" value="H1/H5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00624">
        <property type="entry name" value="HISTONEH5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00526">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H15" evidence="4">
        <location>
            <begin position="74"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="170"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="182"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="201"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="215"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0737355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="240" mass="24690" checksum="31674828F302E76E" modified="2020-08-12" version="1">MTKAAKTAAEPTPVETPAADAATTTDNKSPASKKAKATKAKATAKPAAKKDAKKKQPAAKSSAKAAPAAAKASTGPSYYDCIKEAIQHLAERNGSSRQAISKFVQAKKTNNFQSHMLNKALKAGVDSEKLIQVKGSYKLAASEKKPAAAKKSSAKKAAAAKEVVVKKAAVKKSVSAKKAPVKKTEKKAAPAKKAEKKAAPAKKAASKKAAPAKKVAAKKKATKKVAKKPVATKKAAKKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XBU6</accession>
    <name>A0A6G0XBU6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WRKY19-like zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_006747</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XBU6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015523"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056866">
        <property type="entry name" value="Znf_WRKY19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827:SF1">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24906">
        <property type="entry name" value="Zf_WRKY19"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WRKY19-like zinc finger" evidence="2">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="WRKY19-like zinc finger" evidence="2">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="WRKY19-like zinc finger" evidence="2">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0737592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="301" mass="32427" checksum="AA9D9A1BB49DEECC" modified="2020-08-12" version="1">MEVLAPVDDMKKANAQDAASAVNTSPDNSSDIHTVALSMLILKGDTRECSNESAIPNPPTTTPIFWNPRRVLPIAPKAKRKLNRPYATSGDPKLQAENIDPANGSICPLPSAESNEDSSIGDSTNENPYDSNTPSSQQRSAYLLSEESTLDESGLAKSNRARQRQMHVFCQVPACNEAATHVSRGLCAIHFKEKLDEGPADGAERRKWASKMHKKGSDVIICTFPRCTKGARSKGLCKRHGGGKRCGIPECTRSDQGGGFCIKHGGGRRCSVDGCKNSSQAKGLCKRHGGIRIERSKKLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XCL1</accession>
    <name>A0A6G0XCL1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cation-transporting P-type ATPase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_005917</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0737921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XCL1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020011"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140358">
        <property type="term" value="F:P-type transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF8">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0737921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="15157" checksum="DAD924D0CC0E5C26" modified="2020-08-12" version="1">MTNCYTYIPPPGDGYTRVAHENAIVWLFGHWEFALVAMAINLKDPFRQAAWPNNNYFVGYVAAMILLLLGLTLSHQPTLLEWFELAPIPTTFRLQILGIVLLNVVCTIAWEYIVTRHLDKASAMYAMAEIRIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XCN0</accession>
    <name>A0A6G0XCN0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Globin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_005937</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the globin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0737941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XCN0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021101"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008941">
        <property type="term" value="F:nitric oxide dioxygenase NAD(P)H activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071500">
        <property type="term" value="P:cellular response to nitrosative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046210">
        <property type="term" value="P:nitric oxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396">
        <property type="entry name" value="FLAVOHEMOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396:SF3">
        <property type="entry name" value="FLAVOHEMOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Globin" evidence="5">
        <location>
            <begin position="41"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0737941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="247" mass="27459" checksum="6F41C6F6BEE1EEB4" modified="2020-08-12" version="1">MGLTYSVQALRVLPNGELVLHRRYNAYFANHCPEFAKVRCQITQEVRELVAANWKAITQGATPAMKAKGKIQPLVYFYDFFYNTLFVSAPETKPLFKTSIIVQGKALIAIIESVVNAPSVTTVIEGVVGLAYRHNKYGVKIDYYNTTGSILLQTLKECTGDEAWTPPLEHAWLTVYAFMLTAMAPVLLHGNVDPSDEELALAKQGRYKQRLTLRGGIKVKPVARVETALFDAVPPTQCPVKDAWAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XCU0</accession>
    <name>A0A6G0XCU0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="6">3.2.1.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_005996</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="6"/>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0738001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XCU0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016177"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF34">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0738001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="435" mass="48922" checksum="7B52627E6B5997CE" modified="2020-08-12" version="1">MKNDRALDEPVAKVSSSVVILRRLLWFCLPLGVVIGACILLSISQRPATPNYHMSYAITERHVKVQGVNLAGWLVADYLVTPSSVIYQGVPTNVSALGEFAVADWYKNSNKKAEMDTKFKSHRDTWITEDDIKAIAAAKLNTVRVPIGFWITGTNYTESITNDPTNWLPLRYSMFTAGSADYLDKLIKVWAKTHNISVLVDITAALGAQNSKPSSAPVTTGRNFDLAQNKLAYNATTDLVKFIINRYKDDDAFLGLGLLNEPERTPNPTLSQRELFAFYRSVYPWIRNLTKRAILTTQSFGDMQRKGSYSFITDNDETMMTFSIWPEAPETVVNHWQEWHKTETNVTAFMNESMFNAFKNDITGWTGNPLFIGSWNAVKNFSSSVDTATWAKKVLDVVNLAPKGWIYSNWKNDGKNTIPGWSFKDLLAQGVQLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XDB9</accession>
    <name>A0A6G0XDB9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SS18 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_006134</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SS18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0738156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XDB9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004993"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007726">
        <property type="entry name" value="SS18_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05030">
        <property type="entry name" value="SSXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SS18 N-terminal" evidence="3">
        <location>
            <begin position="8"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="63"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="101"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="222"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="283"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="305"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="325"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="343"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0738156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="380" mass="40988" checksum="1829391C37A9ABB1" modified="2020-08-12" version="1">MEPEHKYISTENIQSMLDENSAMIVEIIQLNNAVKHERGAQLAEVQDKLDKKRKKLNRNLMTLAKWADESTEPPVKARPPPVQQAPQIQAPQQSTQQINPIAQQAPNAYGNTHQQPQEDQVYAQSNPADTFQQDAPPSDAAPVETKPDDMPQDQVMESAEEPAVDTPGDASMEVSEEPAVNEAPEDESMDPAASDFDAENAAVKEDTEQVKEDEEQVEDTVEPVKAEDEVEKPLKEEEKVKDDEQVKEEEPKVEEPIKDEEMAPEEAAAPEDVKTEEPVAPDAVESTEAEVASTESAAEEVAKSEPPTEAETAPAAEETEDPVAEEANAPEAPVAEGADAPQAPEGESATTTSEEAEAPATEPTVEASNDAEASAPSSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XDG2</accession>
    <name>A0A6G0XDG2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HPP transmembrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_006086</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0738097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XDG2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004076"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007065">
        <property type="entry name" value="HPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058581">
        <property type="entry name" value="TM_HPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33741">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN DDB_G0269096-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33741:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN DDB_G0269096-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04982">
        <property type="entry name" value="TM_HPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="HPP transmembrane region" evidence="2">
        <location>
            <begin position="71"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0738097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="242" mass="26166" checksum="906C4E7E8000EFB8" modified="2020-08-12" version="1">MQFVVAETPGAATTATLNAETKPEPTKNVLGDYLRRFRGVETPPEVNPTFRPFAVEPALRSATSLDESRRRKSITVTIWSFISSFCGIAILAALQYNLHSTYASGVKVTAIIGSFGATAILTYGALQSPLAQPRNVIVGNVLSSTIGVTVFKIFRGLGDDYMWLSCALAVSLSLVVMELTDTVHPPGGASALIAVISGPDIEDLGYMYVVMPVFTGSCILVLVSVVLNNIHRQYPRYWLYKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XG08</accession>
    <name>A0A6G0XG08_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_005279</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000067">
        <property type="protein sequence ID" value="KAF0739099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XG08"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015996"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF155">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HERC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="254"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="312"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="362"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="426"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="4">
        <location>
            <begin position="827"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="4">
        <location>
            <begin position="888"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="4">
        <location>
            <begin position="969"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="4">
        <location>
            <begin position="1101"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="4">
        <location>
            <begin position="1173"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1015"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1025"/>
            <end position="1051"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0739099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1235" mass="141915" checksum="AE53AA07CA02B6D7" modified="2020-08-12" version="1">MTGKKSDKKDKKEKSLTKVDKKRLLKRGRLEWGLHMTKKQHFAATMIQRKFRAYRMHMEHREARARVRSSMQRIKQHHVFFDREYWERVNLRDLKRAELEDLAFRLELPIFQRKKEVLIQTIQRWIDLRLHVQDVAIEAAMPQGCVYVLPALPQAEPWIIRPLNGRNISTVAAGYESEALYAIDSVKGIAWLCKTSGLASQIGFCSTLTNQDVFNLPYQTTWLANPMPMQTLRVGHIEAIHVAHSHALARAKAGEVYSWGSNPHGQLGIEKAAQHHQLPLVVETIESYVTQSIGVGAQHSAAVCDQVKGRNGVLFAWGSNSHCQLGLDRGTFKPTEVTALSGLVVRKVACGTLHTVVVTDQGDVFSWGCNDGGRLAHGINCEDDNIIRQPRKVQGFSKPFDKAIEIACGPWHTAALMVERLSQQSGVICTWGNGVCGQLGQGSALHATQPQMVPLPPMKNPNDPRELVKAMACGLHHVAALTENGNLYTWGSKKEFSPLPHKLPSTKVARGRIVSIACGGTFTAFCIAAVDEQLYEPQHRHLLWHTRSNVIPKLDFSSIPPLPLTSSSHCIPRLQPEIDRCMKELEEHEARQAFESIDLNEMLYPRCRLCWRCPGFKPDMNKLAMCRICRHRREHHGKRHGPMSEYEAVRKLQSKYRQRQGVKYLHQLFLERVQRVFSIRHDMFFYYNTCNRMKSWTKPRLLPPNLDCPIRDPDDEIVRPPYTIDDAASVIQGLFRARKARKLVHTIQRYRYETCVDANGRTYYRDRRTNAVRWDNPFKYSPQPRRHRKPMTEAEATATLQRCVRGGIARKQLRKMLQKRFKALIDSATGATYYFDAKTKEVSWTKPRFFVDKVEDSKPKLPKYTDDSAASALQRIYRGRRARRRLISLLQARYQQAWDPKTQKTYFINTVTKETKWEKPALLQNVDLDKVPVHHKRHKKKAYNMSDVDAAIRLQAVLRAKIKRRRAQKEVDRAYERVWDSKANAHFYHNKTTKEVTWTRPPLWDDALYEKLTLERPVKPQAPDAKTDEKTNEKDSETQPQDKEPEAKNDAPESAGAAGANTPEKSQRTRRRQYTVTDPDEAARIIQAALSRNKCQTQSIKSLVGRFQKVYDPNTHRYFYYDQVTKESTWTAPLLLKKFQKANSPTKYKTPESAAVRIQGIFRLHKARQEALQLAQASYEKVFDETIQAYYYFNTRTGESQWTKPKCFRDADAVHVLKLDAHGKVVDTSNISSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XGX1</accession>
    <name>A0A6G0XGX1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_005030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000064">
        <property type="protein sequence ID" value="KAF0739465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XGX1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014373"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052050">
        <property type="entry name" value="SecEffector_AnkRepeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586:SF3">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0739465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="411" mass="45392" checksum="32C96B86821AF0F9" modified="2020-08-12" version="1">MADDVLLNAVLLGNITAYQVGIYHDLLPLCDLRRPNLKNRYFFPQATITKNTLLLTPWLEVYGTSRVRRSMAVFERLAFCLATHAAFVGDDALMLLLEELEGLPTDVALIDIAANYGHLSLVQLLHSRSYATTWAMDWAAANGHFDVLEFLHLHRSEGCTVYAMNGAAMNGHAEIVQWLHFHRQEGCTKNALNSAAEHGHLEIVKFLHDHRTEGGSEQAINFSASNGHMETLEWLHWNRADGATTSAIDWAATNGHFDAVKFLLAHRSEGGTSLAMDGAARNGFLDILIVLYAAGLTCTTEAMDGAATNGHLDIVEWLQAEVDATCTAEAMVGAARNGHLAILQWLFMHSKPRDDQRVLCAAAEEGHLDMVSWLLENGIHKTRLVSQALHKAMSRGHIEIVELLCERATDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XH98</accession>
    <name>A0A6G0XH98_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_004851</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000063">
        <property type="protein sequence ID" value="KAF0739682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XH98"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009056"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17724">
        <property type="entry name" value="BRCT_p53bp1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047250">
        <property type="entry name" value="BRCT_p53bp1-like_rpt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047252">
        <property type="entry name" value="TP53BP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15321:SF3">
        <property type="entry name" value="TP53-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15321">
        <property type="entry name" value="TUMOR SUPPRESSOR P53-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="421"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="570"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0739682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="696" mass="77964" checksum="23A162B55EA1287E" modified="2020-08-12" version="1">MSASDVYREMPYHAPKRPSLDAVPLVVSSMEASTGITTQTPSSAEYDDEAEINHFYHMQEAYEATQILETSSPIHNGEVSDAETQLFSVDDEQLTQMIPEDEPIPTHQQVEMHCTTGETLKIQSHRESIDHSSAVQSPSSTSDKVESRTRDYDTTVMEGKSQEELQFATTTMNLSEHAKNYVQNDASVDEKASAVTTMSSSPNGKMDSEPNCEVRDTTFQLPSNNSTSHPESSQAPSSESIPWITSKPGFTKKEESIDNETAQARSEPVPDYDSIYDETEPPQSPPLTSYLNRRVKEAALVTPDRAHGFEFDENSEPSLSQQSIASKKRSYAFLNENSQSQQETQESPPNLSRLAETTLHAAMHVHGYISSHTRLKQEDGDMKKEFDIPPKSLNFTTPSTRRVKRMKVEFSPIPPRTVYATRVKCFAGASFYLSGFEETAGEQLKGQIQSYGGSILKCVEQMKKHAEKCYVIATPEASRRPKILYAMTYGVPIVHPDWLAACFAARRCLDVTGYWIPAGFSWILRRSVVLLPKHQDLLFKNLRFGVPYDISNDKRKKIHTTIAKLMKIPLEHCGAQFVKTDIKRTAIVKGNVDIILSNEFTKLCSVAQECDIPVVRFLWVNECIIQGSLVDMKDPNLAPDIFAEDGTLHTRVVEITLADTTAQQRLCLGELVFVDLDDKPHDILYHICQSASVQKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XHU1</accession>
    <name>A0A6G0XHU1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nicastrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_004598</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nicastrin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000059">
        <property type="protein sequence ID" value="KAF0739852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XHU1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011388"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041084">
        <property type="entry name" value="Ncstrn_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008710">
        <property type="entry name" value="Nicastrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21092">
        <property type="entry name" value="NICASTRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21092:SF0">
        <property type="entry name" value="NICASTRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18266">
        <property type="entry name" value="Ncstrn_small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05450">
        <property type="entry name" value="Nicastrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026265984" description="Nicastrin" evidence="11">
        <location>
            <begin position="20"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="671"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="Nicastrin small lobe" evidence="12">
        <location>
            <begin position="37"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0739852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="703" mass="75306" checksum="2A1C19A02A34C086" modified="2020-08-12" version="1">MVKISAAAVGLALISCVNGGAVTTGAPQNPIVAGGECVRMFHSKGDVGCFSLDKDGTRARLVAITKAEDFVQSTLQEESIVVLPDSLFTKENLAQLNGEWIKGVMVYPTNSSATFNYEVTTPQGKGTVDGGLNPAFGDYVWNPKGRGIMAQSLPYPIIEVESEASVQPYLDMARKNDNTGTGNTFGVVFKGLMEYYFGPSKMDSISCLNFKNIYGDRSPKCLPVGGQSAWAVKGDLSIDKPLVVAMAPMDTTAFSQVYAPGANAGASSLVALLAAADALKSIASTSLKKHIVFAAFQAESYGFVGSRRFLADLQASCATTVKSATPFGTSFCASPITSTLAFKQISLAKIDAAIAIDQVGQTTNDKFYLHLNPKATKLSNSSILQWFTNAPSAKGNFNQSSVEAIPPGPLTSFLNDKEYGNASLVSAVLTGYDSAFMPTYHSRADTNNSIQADKVVQAAQVLAEALFTAAAAPGTAVPSTISVNATLVADLMNCITSNWRCGTMKAYSKLLVTSMNDYLDFTDSSIPSYMQPVHLYTSVYSENRMPTIRVNKTTVEAKLDQPWQDSFKLNLYPNAYETFTRAFLAVSVADPNDSPKSCSTITDCGDDSLDCIYPGVCARRSAYFHDALSPGLEREVTYGLYKVVNESMPLWTEPNWGTLGTLVYPDPGNTIGYVTLGSGVVSIGLGYILSSRFLAHFRKQKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XIN3</accession>
    <name>A0A6G0XIN3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5'-Nucleotidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_004220</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000053">
        <property type="protein sequence ID" value="KAF0740215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XIN3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010439"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF48">
        <property type="entry name" value="5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="4">
        <location>
            <begin position="49"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="5'-Nucleotidase C-terminal" evidence="5">
        <location>
            <begin position="321"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0740215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="524" mass="57126" checksum="CDB93EC8C7F7F864" modified="2020-08-12" version="1">MLMLARADNCGSVAERPPTAELQIISYNDVYEIKPYDAGQGILVGGPSHIVPLAKTLRKNYDNSLVIFAGDTMSPSLWSAYFKGLHMIDAHNAIGVDFACLGNHEFDFGIDAFLNVSAKSKFPWLNANAYEIATGQLLRGTKPNAVKVFKSPTMGSFKVGFFGVMYDMKDDSKGMRWTDPVEAAKEQVKYLRTVEKVDFVIALTHQGLEDDNRFSQAVTGVDMIFGGHDHSAMYQTQFGTPYLKSDLDFRNIWLSHLKWYAAANATNSTSATPAFTKMTHKNMPITQALPTDAALDALIAQYDAQVKELNKEVVGSLCQATDLTKLTVRYKEAPIGNFISDAFLNYYSDRVTVDMSVMNGGGIRTDRIWPAGQVNLGDVISWSPFGNVIQVVATDGASVKKFINYIMKDSCGANNLVAENGLYLHMAGVKYIFVCNGVGSGAVTEFSYLGKRAGTAVQDTDAVNVAISDYMYAAFTKAGGVTTKMIVTAAEAVRTELCVATYTKKQKDASICPSAEGRSLVKFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XIS2</accession>
    <name>A0A6G0XIS2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TATA box binding protein associated factor (TAF) histone-like fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_004482</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000055">
        <property type="protein sequence ID" value="KAF0740040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XIS2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020223"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22931">
        <property type="entry name" value="HFD_TAF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08050">
        <property type="entry name" value="TAF6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.770:FF:000001">
        <property type="entry name" value="Transcription initiation factor TFIID subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.770">
        <property type="entry name" value="TAF6, C-terminal HEAT repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037796">
        <property type="entry name" value="TAF6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011442">
        <property type="entry name" value="TAF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046344">
        <property type="entry name" value="TAF6_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004823">
        <property type="entry name" value="TAF_TATA-bd_Histone-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02969">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07571">
        <property type="entry name" value="TAF6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00803">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TATA box binding protein associated factor (TAF) histone-like fold" evidence="6">
        <location>
            <begin position="2"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0740040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="445" mass="49922" checksum="0CA74395A0DF7352" modified="2020-08-12" version="1">MSVLREESIAVIAQSIGLTSLSKGCAAELAPEIEFRLREIIQDAMKFKAHARRDRLTTRDINHALSARNMEILYGYGAGNKSVTFRNISPGLFVTDDPEVPVSEILNAPLPLCPVEPSVHMHWLAVEGVQPKIPENDVDDASTATYTTSITDPSFTGAVQRKPLVKHVLTDEMQLYYDKVTEAIKGGDFNRQQAAYVSLGKDPGLHQLLPYFSKFIYDEVKNSQRDLVLLSSILRMARSLLSNESLRIELYLEQLIPSILTCVLNRQLCENPADDHWAIRKSAAKLMAQICHRFGSSYENLQLRVSKTYHDAFLDPARPFTTQFGAIVGMYPTLNLDSSDAGCLYLGPLVMETLLFPHVTTYLTRLEPIMSPSNPNHVQRLEALHCVGMLEHAAGQYMAQQSTTRRPFMSPEFLQTMSVLDDVFGEALHPYVHASLDTTYMDLTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJS0</accession>
    <name>A0A6G0XJS0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_004066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000051">
        <property type="protein sequence ID" value="KAF0740520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJS0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013618"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0740520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="219" mass="25360" checksum="240BAE1D197CF2FA" modified="2020-08-12" version="1">MAVPTEKQIRRRLQCKINMRNYRDRRRRSTEVLEVAVRRLEQDIDHLESRKIMLYRSLSLQSDMATAVVGEYIKLLSDFQFGERQIQFLRMNFSPDFTNNGKPLDVFIDGWAKTAKFLAGPKSILGLCVIDNQRIELRVQLDVELTREVIAASFGFLLDNENEATVDALLTSNPVIQLHLTRYFYFDQAQVTHSTMVDDRYAQITALVASVRQRLSLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJZ4</accession>
    <name>A0A6G0XJZ4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine protease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_004005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000048">
        <property type="protein sequence ID" value="KAF0740630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJZ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009207"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36234">
        <property type="entry name" value="LYSYL ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36234:SF5">
        <property type="entry name" value="LYSYL ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13365">
        <property type="entry name" value="Trypsin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026122706" description="Serine protease" evidence="2">
        <location>
            <begin position="22"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0740630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="787" mass="82880" checksum="1719240E67E3BE45" modified="2020-08-12" version="1">MARNAFSTAAAVAMTLLSVLGTPTDKVLAVVSFPVHIGCSTGATPYVFPVATTPSVVFSMPVHDPAAEFISFNVTALDLPPRDYIQVRPLNASAPVYTYRGHYPDGILTTALFAQDVVFELISFGSTNSNCEYGVSVADYRFSATPPAHESTCDTTDDANSPACNRLSVYWQGSQAVVRLLINTADGARWCSGWLVGCENHVLTNHHCIASEEDAAATTFDIQAYGKCHESCIGGGSCSAGNVVVGSTLIASSATLDYALVQLASPTATSTFLQLQPTTPVGGRIYIPQYAYGAGMVVAIKTNSKYGLLETSTYSNKDCGLDGMVGYRLNTSPGSSGSPVISTTTNGVVAMHSCGGCSVVANGSLNGGIAAGWIVQDLQAKNALPKCALAPQPPSDGVVEYTSVRGTLYRHARGVTMDVHMLSLDSDGVLELDLLSYEKTSDGVFVDVDNNCDASYFDSKVYLVASDGSIIGVNDNSVHGNGRADGSVNDLDAFLTFNVDPGQYFVVVGTTDMSDTDAELAVTQQMLYSAGGLMECGLSSGSHGHYTLTIRTNIDPESISAFVPTTSAFPSACDASSAKAQAPSTCPSYHQVPALNVPYIVDGTIVQTNETVSIDQVPFELLEATHLSIEVVSFQALDDGSILPEGFDDQGFCGRTYIDAVAYVFEDTTANQLKLIDTGKLIAACDDKAPGFDTPSGLSRSSRDPFLDLFLLPGKYVLVVGQYPLKLQDAPRSSVASTPGFYPWRQGVPSSTGTYHVVFSTTRAGILSPPCNPPSFIPESCSVATGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XKN8</accession>
    <name>A0A6G0XKN8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_003563</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000041">
        <property type="protein sequence ID" value="KAF0740991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XKN8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004587"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021418"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35871:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35871">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0740991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="601" mass="68219" checksum="A16F81B5FF5C0BD7" modified="2020-08-12" version="1">MTVDVDWTALLLDKMVAADVARLHPKRKLFRDGTSSRTLRRKKMLNAKAHSACPMQQLDNWFLVSGAPTEEATPNMPDLACVKQLQEILTGKDLNKTLFVKLAVVLKFFEARMDGASRLSAATTVANCLPSVFHLGPRTVQNWAKAYARDGQLPELQQGKHQKSSSMIHDEDFLSKCGKWLRTTLPPQRTPRNFHLYLNEILLPSLTGALQRYKYGAWSKDVFLDGYERHDVVEYRADFCRKWIELSKRMVSYTGPDMETVECPENSVLEPVVWLTHDESVFYANDDGGMIWTNSAHPDLPKKSRGRSIMVSDFLCPCHGRLYMPVGERQQYVRELLHIGKTQEGYWTSDHVVALVKDKVLPAFAALYPGCLALITFDQSTNHAAFAPDALRTTSMNLNPGGKQDKMRDGWYGLNRTLQKMVFPEDHHVLDLRGKAKAIKAVLVERGAWKPSMRLTCGVAVDIPPSPAILECCARHCLASFDDFRSQKSVLEEIVTSAGHVCMFYPKYHCELNPIESYWGAAKRYARQHCDCSWNGLVRCVPASLSSVPLSSIRKFFRRCSHYIQAYNDGINFAMTKYAHKQYKSHRRIPQSIATHINIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XKZ7</accession>
    <name>A0A6G0XKZ7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_003767</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000042">
        <property type="protein sequence ID" value="KAF0740877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XKZ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000236"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000016">
        <property type="entry name" value="FACT complex subunit SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF15">
        <property type="entry name" value="HMG BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00886">
        <property type="entry name" value="HIGHMOBLTY12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="42"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="132"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="42"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="132"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="82"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="199"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="208"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0740877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="236" mass="27031" checksum="92D69EC178D3A8C4" modified="2020-08-12" version="1">MGRGPAKTKKEGGSSKRGAASAAAASSKQTRKPRKKKDPNAPKRALTPFMFFSKECRETLKTEMPHLAFLDISSEIGRRWAQVSDQDKKKYEQMAQKDKDRYQDEKDNYTPDPEYENAKTKGVRTKKDPNAPKRPLSAYFFFCQEHRAAIREKNPSKSITEIAPLLAEQWRSLPEKKRAKYNKMASDAKANYQVEVAKYKNGGSAAHDDDEEVEDEVEEEAQEDEEEEEEEEDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XL31</accession>
    <name>A0A6G0XL31_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flavin reductase like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_003692</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000041">
        <property type="protein sequence ID" value="KAF0741128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XL31"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003004"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053310">
        <property type="entry name" value="Flavoredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43241">
        <property type="entry name" value="FLAVIN REDUCTASE DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43241:SF1">
        <property type="entry name" value="FLAVIN REDUCTASE LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="2">
        <location>
            <begin position="29"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0741128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="249" mass="27078" checksum="9C0B44AFE9062D75" modified="2020-08-12" version="1">MEATDDVDSGASLPGVAQVDRNMLSRLLYSNPVCLLSVADATNGTRNVMTITWLTPINNHGKFICSVNCKRHTASFINQVGRLFVLNVPTADQEELILAIGGCSGATTDKFATLGIETCDVGWLPPRPLKRKHGLSKKDRIALEIADAAASCIAIRDVIAHILCRVEKIEVEDGHYIVTGLQLAGFVKASYWNGKNFAPTSADAAPYLTFLGSKSFGKYMKSTKETNLPRHPLEGKGARDARNVRHEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XM38</accession>
    <name>A0A6G0XM38_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zinc knuckle-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_003464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000037">
        <property type="protein sequence ID" value="KAF0741353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XM38"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016717"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039715">
        <property type="entry name" value="ZCCHC10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13491">
        <property type="entry name" value="ZCCHC10 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13491:SF0">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13917">
        <property type="entry name" value="zf-CCHC_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0741353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="150" mass="16369" checksum="F08F3A6CEA7B32F3" modified="2020-08-12" version="1">MDSRPQARSGMLYGSGRPGLGRKTTDASNATCQKCLKKGHWTFECQNKAVYVKRPSRSKQLTNPKLRQPFNTDKPPERSVLEVSGEKVKGDDKLKKRSKKKKHESDSSSSSSSSSDSSSSSSGSSSSSSSSSSSSSESESEDERPRKKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XMB9</accession>
    <name>A0A6G0XMB9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_003288</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000036">
        <property type="protein sequence ID" value="KAF0741609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XMB9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001565"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053061">
        <property type="entry name" value="AN1-type_zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46728">
        <property type="entry name" value="AN1-TYPE ZINC FINGER PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46728:SF1">
        <property type="entry name" value="AN1-TYPE ZINC FINGER PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="108"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="327"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0741609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="379" mass="42361" checksum="C2D4F9B3222B8837" modified="2020-08-12" version="1">MQVLRIDPTTNEASSVVELSLAADSLKALTVAQVKELVVAELRRTSQPSAIFKRLLLGLLSGRTKEPTTSLHYYGHPLRNQDLIEPYLPTLKTPETLPRFVLRNTTPLDIHITTLTGNTFPVVSSPLETVHLLKETIESLQGFPVQQQRLVFAGTELEDDWTLGDYQIPQDATVHLMLRLRGGVEAARLFADVEDEQLLEQHEFASTGSPWRAVDVGLNIHGICTNDACEAKGQHVVAPVKWTPFNLQRHTAKCPMCRLTIEPKTCGFYKCRWRFEGLKLEAHEHVSSPWAIADGEVYHSFNADESKQVAWESLVIIPMPLRVDSDCVFCMDKLADQTKVYGPPCGHLAHRSCVMLWGSYCKANHADVTCPTCRAAIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XMG7</accession>
    <name>A0A6G0XMG7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_003254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000036">
        <property type="protein sequence ID" value="KAF0741573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XMG7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012361"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041646">
        <property type="entry name" value="VC0807_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0741573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="209" mass="23014" checksum="D591E22FAD3F873F" modified="2020-08-12" version="1">MFISVVSPILIYNIASKQTSKANALLLSGIPPAIDSMVAMIRHRRIDVVPSLMVVSISLSALIAGLSQDPKLLLVKDSFFTCIIGTAFLASTFWEKEDIMWTHKRQHRGPEAKAEMDAMYTKPEVKAHSKRVCRVWGGGLLIEAAIRITMIYSLSVDAVAYTSPLLMVVTLTSLGIWTRWFSGAASQPNSEKSAFLEEESSLTSDYSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XMG8</accession>
    <name>A0A6G0XMG8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Ae201684_003176</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000036">
        <property type="protein sequence ID" value="KAF0741491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XMG8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008413"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0229">DNA integration</keyword>
    <keyword evidence="15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="13" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="14" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="17">
        <location>
            <begin position="545"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="238"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="275"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF0741491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="787" mass="88334" checksum="CE2CAF047E57F4FF" modified="2020-08-12" version="1">MNKLQADGSNYREWCVKTRAKINQQRLGKYLKPCRDSAGTYLSSLSEEDDLVALSYIQLSIHNDHLKYIQHVGTTYDTWEALRTIYESTSEVNLVTLQLQLSKLEWSERTGLENFTDQFQEFTRNMTAAGDATPMKSHINRFLCLLPPRFANTVMFIARESRTSSKYDNMASILAELKLDAERQHLSNPSLRKQAGRSDDALNATTNVQCQYCNKPGHIRPECRRRKTDEANGIHQRLIQEKPQASGHGWKGNQDQSRSSFFSGGRGRGQSQQSTSVQDHSNQAENSDDDDEVLFMVEEDVFGATQLDRNNTRQAASVETSNAILDEACIDELCQYVTSNDVTDECNTASMIHNHEAIIDSGATAHMTGDINLLHGITNCARGVRLADGHSIQVTTMGDLKIKSTDTGRVATFKNVLYVPSLKKTLVSISRINRQSDDTSITFKSDQCLLKVKNRISITAKWNASYLYAVQGTFILPDAHDEANIAESANAMLWHARMGHIPAASMTAVCAATTGGPNGIPKLIACDDCIRGKLKHNSVPKIGDRPSHPLGTCVHTDLWGPAKVASPNGAKYFIAFTEDATNYVWVKFLTKKSDGYDAVIEYIPWLERQTGVKLKTLRSDGGGEYVSDKLEEYFKNHGIHYEVSTPRRQWQNGTAERMNRTLVEMARTKLQHANTAKHWWAEAVNTAAFLRNRIPNSKTDDKTPHEMIRGTKPKIASLKGFGCLCWRRNTTTDKLASRANMCTFLGYSETKKAYKVYDMEEQKVSGVLHFHRDKVPSSMDGTYRRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XMT3</accession>
    <name>A0A6G0XMT3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_003290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000036">
        <property type="protein sequence ID" value="KAF0741611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XMT3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001567"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="91"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0741611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="277" mass="29867" checksum="FF1B1850D032C3F0" modified="2020-08-12" version="1">MAAVDNKMAVVWFDPTTNEAGGTIFLSGGEIHSMTTVSGLERHLTSRLNLPRRSKSSLTMYGQRLTAGGVSSYLPLLRTNIPRFVLWTRTLPLLIVPPSGKSAVVWVSPARDVAQLKLEVEAMLGIQPSYQRLVFIGRELRSKMSIASTGIQAYSAVRLKMRLRGGGGGFSKPKQSYGFADLGNNDLVKQFGLRSTTSGVADWRLVCYGLNIEGKAPMKNAMLTASRSLPSITLKHSTSRPTRLSVRFACPRSLPSLAAFTSANGALKACGMALGCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XN09</accession>
    <name>A0A6G0XN09_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Phosphatidylinositol-glycan biosynthesis class X protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_003304</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000036">
        <property type="protein sequence ID" value="KAF0741626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XN09"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011098"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013233">
        <property type="entry name" value="PIG-X/PBN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040039">
        <property type="entry name" value="PIGX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28650">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS X PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28650:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS X PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08320">
        <property type="entry name" value="PIG-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00780">
        <property type="entry name" value="PIG-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026051895" description="Phosphatidylinositol-glycan biosynthesis class X protein" evidence="12">
        <location>
            <begin position="20"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="493"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="517"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="517"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="527"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0741626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="536" mass="58725" checksum="36CF5B7BB523147A" modified="2020-08-12" version="1">MKSMWQCMALFLCASAAAAGEEATTDKGSSAVFWPQEYDDKLSIQGNLVISTGNMMIVHEKQIALDLPNVAWHPSLDAIDISFIPALTSQESNAAPIWSRYVSSTVHTLHDTAGMHIRIHHRGAPVDIKDLQSNVTRVLIDLLGPSYAASTCSVGCESNTFHFESTIVFANASCNLPAYFTRLGQASEQPSASSFCLVSSRYAPGVEVPTLFPSLSKVPSTPLQAILSSSSQIQPDAISEWHIRATHLTLTFEKRVLLNIQQVIESLRQGESVLSVTVSDDIAEAAKVVQSISSDSVSILKSLYSTEATSLTVSSEPTIRVLDIDTTVSGSGFHQLLHVNVQLSHTDNTCRLLIEQPFPTTAYADMDELRRMERFNAFQVIAFAKHIEIERPSALSSEHVVAFVLPLSSTNLTVDVPIHFRYQFPSNQTLYRPVHLVAPSLYLHCESDPTSTDLRTLGIPNNPDTYWKRVTLNRPVQGLTLQIPVGNLNDGRFVTAVTLFVSVLGCLFIFVSLLPSKSPSPAKSTSWIPQSSIKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XNE5</accession>
    <name>A0A6G0XNE5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_002938</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000032">
        <property type="protein sequence ID" value="KAF0742001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XNE5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014019"/>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15737">
        <property type="entry name" value="FYVE2_Vac1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43102:SF2">
        <property type="entry name" value="GAF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43102">
        <property type="entry name" value="SLR1143 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="280"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="346"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="405"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="454"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="413"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="462"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0742001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="735" mass="80401" checksum="3A2051307DA2107E" modified="2020-08-12" version="1">MIPAPAVPSPAVPLPSRPPLLLTEAQQTELYHQSRNHAVSFLQNSLSDLHEWEFISEKKSVQFYRKKSNDGTTYTINGITRIVADLDETMRTLYCEDSLSLGNLLSQLHDDAFSDGAVLASLPPKRDPSGICREQCSVKTLSFRPFNAMDKARQYTVVDYCTIRTGKADDANDATDNRLGIQLMYSTEVADRRPGSSAPVGDMDCVSQLLPSGFIVYPTAKKGVLEVIFSWSAHDPRGISRGYKKSILSLVASVARLENIFLALRIAAAGFIKSKNWVSDKDRSYCFICRESFGAFRRRHHCRLCGDITCSKCGTLTAVKLPVVGLCQVRICNRCLKENDSSRINVTLPTPQLPSNSRHSVTQRSSDASSQVQVMERLSHGMSNLSAVPVQHQIDSDEEDEIYGVQPSQGLTGSRSMESASMSSGNLSNPTNGSRLGNAAAIDEDDEVVLMPHPGYSEQTVAPPPQAPPAPSSSGFIPLNSNLSASSSTLSTHVKQFSYPLHYTEGQAWPLAPIPSEEAPRLRKLDDLRILDTAPEAEYHQIAQSAAEALQAPFGYISFIDAKREWIKASYGVGGAAANSSIPRDLSLGAHAIMSYEVTAVPNLPADVRFRDNPLVTDGIKLRCFVGFPLVTPDGFIVGVLAAADTRPREHVTLSQVARLKQLASNLSRLLEERATYHSVGGPMYPQAHSQTYNQPTAQSMIHNTLLDLLKKTEATGKKLQETQQSMMNAGRQNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XPI2</accession>
    <name>A0A6G0XPI2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_002528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000027">
        <property type="protein sequence ID" value="KAF0742426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XPI2"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0742426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="199" mass="22242" checksum="B4DE0485EFE59B8A" modified="2020-08-12" version="1">MRYTQAPLHNRVDSARLFFIGIFILGVVDVEVTQFVGRLVRGNHVQVVTQLLLLQVLLGQVLQVALGERGDDRNVQLGLFAGDLDNVAQDTGLAVHFDAVVQELFERGNVQNLVIDWDRAVNGELQGGLLARLLGLLVLRHCKRRFTTTGERCCCIVRRSSTRFQDALFQARAEKRTLQLAFSSTQLTAGAMIRVRQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XPW4</accession>
    <name>A0A6G0XPW4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_002626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000027">
        <property type="protein sequence ID" value="KAF0742534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XPW4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014661"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="1">
        <location>
            <begin position="59"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0742534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="138" mass="15046" checksum="D7FCA84854173ED0" modified="2020-08-12" version="1">MGCNQSSNAVAEEQPKVVAAPASAGAQQVDAEPAKHPLVTGHYIDTNGVVLYHVEFQNVVAKKRFNDFKLFHEGLKDQVPPLPAAGFSTVLNRRNDNLIEERRARFQEILAAAPEAQVITFLGIEAQSQPKEEPTEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XQC2</accession>
    <name>A0A6G0XQC2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ae201684_002351</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the centrin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000025">
        <property type="protein sequence ID" value="KAF0742648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XQC2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019833"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043226">
        <property type="term" value="C:organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000178">
        <property type="entry name" value="Calmodulin-2 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000336">
        <property type="entry name" value="HLH domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050205">
        <property type="entry name" value="CDPK_Ser/Thr_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24349">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="287"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="323"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="362"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="399"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF0742648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="435" mass="49061" checksum="ABC3ECE85E01D408" modified="2020-08-12" version="1">MKSASTADIQAEIDMLRWIGTHANIVSLRDVIYEPESIIMIMDLVRGGELFDYIVSQGSITEADASRMLRDVCLALQHLHQRGVCHRDLKPENLLLTETSCDADIKIADFGQSKRLQVGSKEVNSVPGGTIVYWAPEIIKRAPQDTAVDMWAFGVLLYISLTGIHPFDPNGNLSDAQIINLAARGAYDESNPWYSSLSDEAKDLIRHLLTVDPEKRYTASDVLAHPWMHPRLQRRLSGRLRDGLSTRLQGYRRLQQLRANIVTVLLSTQLHSPTSSLRAKQQRLGSLNLQVYEEVFNQFDKDHNGCISKEELADMLQSLGQRYTKDEIDEIMKLADIDGDGGISLAEFTTLMNSSLLQVGQWNDQDLRAAFEIFDTNHDGFISADELAYVMNVLDKSPMSTQEIQDLINSIDENGDGKIDYKEFSTLMKNWLQEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XR05</accession>
    <name>A0A6G0XR05_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_002274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000023">
        <property type="protein sequence ID" value="KAF0742878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XR05"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012747"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009740">
        <property type="term" value="P:gibberellic acid mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009937">
        <property type="term" value="P:regulation of gibberellic acid mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044184">
        <property type="entry name" value="SNE/GID2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47750">
        <property type="entry name" value="F-BOX PROTEIN SNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47750:SF1">
        <property type="entry name" value="F-BOX PROTEIN SNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="10"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0742878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="509" mass="57526" checksum="E567DF7C89AE2442" modified="2020-08-12" version="1">MTAVLNNDHLVREILSRLDIRDLGAAMCVDRLWHSIAKEQNLWSQIAERTLSSLVGPASRSLYNTVGPFRYLELVVTHKQEKTLLRTPCRELVDSSAWTRFVRDNKWTARLHIAYTLDLAIPLMENDDAAYVLVSFAECLEDSFHDLDAAQSLLLQALPLADEPVWIMHHLALLSEKQQDYDQAEQWFERAHSTDSTFVNNTCNYAVFMEERRLDYDRAEALYTEALQQNSPPTTRLDVYYALVDFYTFKRRNLDQAEALLAQAFRFLKQQSLESMAGLDVKVAIQYCEFLVYIRHNFTAARAIYGALVDRCDHEESSEPQVARFLCIGLLSYAIAIVFATGTRSMALKILAKARAMPATASDPVTQRYLLTADCVVQHLLLCRALESQRDIQSLGPLMGLLHYLDGRTANAIQLWSTCIDSLVNVNSPDYAFPGYCTGVVLHLGNNFAVAQQAITKALTVDVHFVQFQNLKFILNEVAQASSMPSTRRQRALQFLEVVSAFFLSQGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XR83</accession>
    <name>A0A6G0XR83_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_002237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000023">
        <property type="protein sequence ID" value="KAF0742840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XR83"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0742840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="183" mass="20117" checksum="44E73270C9AF4126" modified="2020-08-12" version="1">MLKPGKLENKPPLARATRIKLRSICFRLIVGAAAKHIHATAQVGFFFFFLLLLFGFLGSGGSSGVVSTRVSTSSRASGSSSTATNATTGRDEFEHLAFLGQQVGKQHWPVGFDFVARGSNDVSESIRRDFGIAIEEDQGGVRHGQFIMLFLRQSHSSLSFAVKNKLNRSMRQPSRIDWFILQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XSL4</accession>
    <name>A0A6G0XSL4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_001733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000013">
        <property type="protein sequence ID" value="KAF0743589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XSL4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019736"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026338781" evidence="1">
        <location>
            <begin position="23"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0743589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="166" mass="18359" checksum="E1776E2C1D462012" modified="2020-08-12" version="1">MKLTALLASILVAVSLAGFSDTESLSECERKCERIRGTIGISHSGYSKYCECFAQVYSYNPVWSKAVDLKATALLNAANCRFSAQGDIKKYDVKDFPGTYDDCLTKCPREGNSFVWSRGPLGDMLRPTGQDGHCYCKQVPSTFDTKTLDLDSTNSLIFCQFNKVVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XT21</accession>
    <name>A0A6G0XT21_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_001408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XT21"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0743754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="92" mass="10529" checksum="5D4E4A3E9CE7F3D3" modified="2020-08-12" version="1">MPQASPAMLRASPELTCIFRAAWPEVFHVVSGRGSSECRENGVNLCKEKFTTLKCLRLPKATRKNFANLHMMSDKISPARQHDDTKTLRWKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XVF7</accession>
    <name>A0A6G0XVF7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_001104</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057537">
        <property type="entry name" value="C2_C2CD3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21254">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21254:SF1">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25339">
        <property type="entry name" value="C2_C2CD3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="952"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="505"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1145"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1466"/>
            <end position="1536"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="206"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="506"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1155"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1510"/>
            <end position="1536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0744640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1675" mass="188755" checksum="1C1B426EF56A0907" modified="2020-08-12" version="1">MSSVGDDDWPDEEIQGQKATIISLGSLPPHIGGPVYGYVRLTVELSTPDVEMGNIGEWLVRVRWWGSMSTLGKGDLLREKQELCFPIHVPRDSFGRYLEDMADLQFDVVDKQSHRVCGQANAAINLDELESVGGTRKHIVVLKTNSTERHGTLSFHASLVWGDLSTATSPVVPQQGDVKVWKNMDFPPNLPSFNTFNVQRPVDNLRVEHNNVIEKLVQKAEALKRAMEKALDVQENRPSNDIQTILATAKSFGPVDTVDSVTQIYPRKMLETESTPQITEMPRPSPPPVYAKEAVKRIPLEMLLCVDAIKLKVSNAKSSANVYIQHKALFTTTSLMSPWKKVSEFTRKVPFTYSISQPFELNGSTLVFLKTKPMILEVWMKQSTESHLVGLAKLRLSCFAHLLHNKAISEIQAGEDPFASKVYDNVVIKNPFDGSTMGLMACSIWIGDATQIRTIQLKQFEAQRIQAWWRGCNARRKNPLPHCRKDDLKFTEEAQQVDLDTINNIEAERDSFNKPTDQDASKRNELKVDGHQKKDFRSDDDAARIVQGAFRRFKEQLDSTDWMNAQPQVLHDENIEEQLIIDQETIDILNQPVLQQSFPTDIKPGDCYYRVALEITQPCPISGGIEIRYSLHGTISNLWWDTYSPALSSRNEHVLVDTASSTLLNMEIWSPHDSFLGSAVLNMPHFAVQELSVPIKWARQDNCDVEFLPLRVHHSKEILNAKHDSTVKISKPLPATATICVEISSLDIFTDTSDWNVFLTFRIVIGNELHPLSKTAEYNTEYHQYISYKSSPHFLLESPMTSVKIEEHVVIHPALLESMQTNEMTIQVYHHVMNMDILIGIASIPLVTLLYRKRGIHGIFPLDQGALYPGRMEVHIFFLHNHDPLIENDIVLPEPTPSNERLVPNRQSDQTFSIHDYDFLLDESLDKFDHQNVGNADSIVRTENMQTSKEKYLEELTSSADLQDGDAHQSTVIRIEEARNLGMLDGKPPNVSATFFWEGKEYNTPVCFGSTCPEWSYENYFRSGFHEKDFKISIYHHDTITDSTIPIGQAMVDMSILKWTKEICGWYHILDKQNTSNGQLKISVGPTKKHDLSISNDDKVQDDSLSLHELRDLVQNLKVMDASLKQVVPFQHDSQVYSDIMESKEYDSIPNEPDLASHESDHRQPSCQNFLEAPHSRDEEVHEVEPRTAPIQSTGGQNPNQVMIVDESPNETSEPWDDEFLDMNALNIHGSPIDEPFNFLNHGNMGDEVGRRMMPGTLNNGRTDNDIDSTTSLKEHNDFHEECDETETVIGDAKNSETLKSNHSSDHLDVESTFLGVQGHLAFDDHTKLADMNVPEIVSSRFNLDNESNYGLDAASLSSLSRVSEYSVKLDIRELEVFAPQQPSQSEINASIPTTPLTSSVGKAQEVLLLQVLEAMEDMKTEIAALVKKNEEIAHQLSEIPALVADSCSASRVSTCQTDTIASGTIKLNDIPSPESPRKNDAYSPPNLSQEKENDNACVEPLQESVSKETQTMSSSTATKSTATSPSLTSSTLPSDSTVNYIEEIVESASRQDQIRSTNLPDSTPPIFRSYWSDMAHSPRSRESTSHLTIPSLVNTYSQRLEHVNGFASHSGRHWSRETPLEHLPRFFRSTNKIDAEPKPASRHLFDSETERIARIMSGNLEQWMENDSSDEECL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XY21</accession>
    <name>A0A6G0XY21_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ankyrin repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_000454</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XY21"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017286"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021832">
        <property type="entry name" value="ANKRD13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055285">
        <property type="entry name" value="ANKRD13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12447">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12447:SF25">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 13C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11904">
        <property type="entry name" value="ANKRD13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="45"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Ankyrin repeat" evidence="10">
        <location>
            <begin position="164"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="410"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="308"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF11904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0745437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="565" mass="63960" checksum="1485C42D26B21F35" modified="2020-08-12" version="1">MSTAFPLHKAIWDGNAIQVEEILQYADCDELNPREKPILLERDLRGNTPLMLALRCAHASQLPIIRILLKYGANVLTRDAMGWSCIQNATLCDNDDVLTEIFLQAEKQTYENLRARSIALYSILHDIPDFYVEIKIELTSWIPLVSRALPSDTLKIWKKGPYIRCDFTIKDFHNTSWKRGRMTHLLRTFENQPGEVLLIDHDTKSALDVSKVITAHTKADIDTSLEMLYTCKMSTYDMDIAKIDLKHKKEMIKKKTAGMPGKKYEMQHATVKLRLRGAAQPNWSPEGSQENRDNNSLAKAKKFFAHLTPTKTSKKTPQSSSPENTVLVTPDSPVEMHLQVQPGDCLHWEYTSSVAGAVHCKATLFANNTVTYVSGPPLAIQDHGLVVLTWTNTTKKKAVITHHIVHQRQVESQMDHGLSPRRGSTATDGLPTPPMPVRVPNPRMQTTAFHDYFESDPEMHHSFRGLIVPPDERSFTKELKGTVTMSESFAFQVADFLPVAQFLSSRSEQFDTLREFFEMKLPPGFPIKFQLPMMLSVRGSYTFVNAGPCTADDYHFAIPSTYTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XYY3</accession>
    <name>A0A6G0XYY3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_000213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000001">
        <property type="protein sequence ID" value="KAF0745765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XYY3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000416"/>
    <dbReference type="OrthoDB" id="10542586at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0745765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="129" mass="14477" checksum="9431AAB879CA66DB" modified="2020-08-12" version="1">MTRRRGNAPHPNGPIGGLIGQHFQTDSRKSSFSNMLARTQSSLTRLPTLTAARGAAARYISAAPRSNENDSLKTEEEPHVAKKDLWTDVFGMNHPKGVRDEEHPHVELMSTPEKNHDDVWTRVFGHRDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W2H1</accession>
    <name>A0A6G0W2H1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_019212</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000499">
        <property type="protein sequence ID" value="KAF0721175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W2H1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019507"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0721175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="261" mass="27549" checksum="5DFF28DF792FC3CC" modified="2020-08-12" version="1" fragment="single">MAVDLCSTTLTGISAKSSSFPWCSIWEGLGNRRVDIAKLKKVDCIDQTCQFVLKSIADYQATLASTGISCTVTDTSTGSLINITVLGSVCDGIAVTKTAIPSNFQNITTYTPSPISFLTPAPTFLSTAPTPAIPSTTTTPSSSGEETKSSNSTGIVIGVSVAAIALIAAILFVIWRRRRAAAAGQALPSNQPYGRLNSPQPNSQKPSSGAGTTSSSHKDGNAFELDKLDLDMHRVTWNEVHLVKMLAQGAYGEVWLGEYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W3I2</accession>
    <name>A0A6G0W3I2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_019115</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000397">
        <property type="protein sequence ID" value="KAF0721495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W3I2"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="48"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="81"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0721495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="125" mass="13711" checksum="1811DC60E427952F" modified="2020-08-12" version="1">MPSDDDYAKNRVLMRRFVLHEAVRNGDLDGMVKGLLTSNTKIDGIHERSNQPLHVACESGHLAVIKFLLDKGAAINTTGHDNRTALHFASNYGYLDVVKSLLENGAALDMKSHARPLVLMKGLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W3L4</accession>
    <name>A0A6G0W3L4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_018983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000370">
        <property type="protein sequence ID" value="KAF0721703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W3L4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017881"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0721703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="327" mass="37989" checksum="9CE04CB378970268" modified="2020-08-12" version="1">MAKLREARRREIQALTTQIQNLESVLQHLQAHPDQQQQRVNPFEYARRVQRRRKDYLTSKLLTRARLIQSLTGWTIPQQLSQGYIEIRLANAQGSRQSGVDWLTKKPYHMSLQAEPFDSEQRPVEDDIKVKVHVGDDDNGTFIHAIEYRLQRGGFHAATALKDCQEFREHIVYVVQENSHYKYRRLSVVGVFLDDEKDRITITQTGIALDDRFPFTEGESRTNGFQWVVFQHVTYHVTIVRWSNSNLCPVNANGRLALRQVAEGMRCDLNPSDSDELIVAKIESSMERALLNIRDLFRHRCGRFKLEPMKSREPMAGSRDFPLESQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W3P2</accession>
    <name>A0A6G0W3P2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_019080</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000386">
        <property type="protein sequence ID" value="KAF0721562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W3P2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003656"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19496">
        <property type="entry name" value="Elp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019519">
        <property type="entry name" value="Elp5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15641">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15641:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10483">
        <property type="entry name" value="Elong_Iki1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0721562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="319" mass="35719" checksum="9F01B86517CA7BAE" modified="2020-08-12" version="1">MTSKEGGSWESEIERYFQRKCVSSSTQSTPTSQVLLQDEETRTSVVVVEDCLATGGIGRAVLQHIVQLVPAKVIHIRLEDTSSLEKVNGHVLRYDDNIAGWFDSIDGDLLQRILRDIEATIASEKTIIAIDSLSALLQQASFRQVAAFLRRLQANPSVGAIFGRFNTSLHERHVVLALRAQATAYLIVDTPASIASYHFLSKESKRVVPPHMLGRVAFCRNLNNGKPQEVIEYMNAIKTDSESRLYLTKHESVERGAAKDLTTLDVSFNLSISDRDQQAKQKVALPYQHQGKTTDQAMFFIDQDDPDWDDDDLDDDLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W4A7</accession>
    <name>A0A6G0W4A7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_019093</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000389">
        <property type="protein sequence ID" value="KAF0721539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W4A7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019710"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015086">
        <property type="term" value="F:cadmium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034755">
        <property type="term" value="P:iron ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001046">
        <property type="entry name" value="NRAMP_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01197">
        <property type="entry name" value="nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037982">
        <property type="entry name" value="Nramp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706:SF33">
        <property type="entry name" value="NATURAL RESISTANCE-ASSOCIATED MACROPHAGE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706">
        <property type="entry name" value="SOLUTE CARRIER PROTEIN FAMILY 11 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01566">
        <property type="entry name" value="Nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00447">
        <property type="entry name" value="NATRESASSCMP"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0721539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="386" mass="42521" checksum="F1AFCEAFE72C994E" modified="2020-08-12" version="1">MELETEPILGQEVPRRPSNAAEFEFVEHVDVKEWVELENLAIARGEVDVPDEDTEHNVCGYKFKFSWRTLWAYAGPGWLMSIAFVDPGNLESDLQAGAYGGYQLIWVLLFATIMGFFLQVLSARLGVVTKKNLAEMCHLMYPRWTSYVLWFMAEVAIVGSDVQEVLGSAIALQILFKLPLWVGCLITAVDTFSFLLLHQFGIRKLEALFMTLVAVMLVCFCTNAIQGGTDSNEVLRGFVPSVPSSYATTQAVGILGAVIMPYNLFLHSGLVQSRAFDRHDDRKAAQANKYFAIEGAIALAVSFLINLAVVCVFAKCFFSLDCLPSFLQDGVNTACLPSGSTGGKAYGTCKLANSPALVRIDPSTNFIILWSRDPAKKLGCRVLALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W5Z0</accession>
    <name>A0A6G0W5Z0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ketoreductase (KR) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_018614</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000344">
        <property type="protein sequence ID" value="KAF0722187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W5Z0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007011"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43963">
        <property type="entry name" value="CARBONYL REDUCTASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43963:SF6">
        <property type="entry name" value="CHAIN DEHYDROGENASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G15350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0722187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="190" mass="20643" checksum="EA26D122849AB3C3" modified="2020-08-12" version="1">MSPQVYFVTGANKGLGYETVRILAEKFGDQAVVLLGTRSLKNGEDAIAKMKQANSSFDYANVQLVEIDVSKKESIQAAADFVKAKYGHLHVLINNAGVGGTKEGPEVCFQVNVFGVVDTWTAFQSLLVPHQSTHIVVASMAGAWTLAALSPELQTIFENFNALDIDSLRALLDDWLAYSQGKASKYSWPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W792</accession>
    <name>A0A6G0W792_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_018004</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000319">
        <property type="protein sequence ID" value="KAF0722927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W792"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003742"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016814">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01298">
        <property type="entry name" value="ATZ_TRZ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000014">
        <property type="entry name" value="5-methylthioadenosine/S-adenosylhomocysteine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050287">
        <property type="entry name" value="MTA/SAH_deaminase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006549">
        <property type="entry name" value="PRK09045.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43794:SF11">
        <property type="entry name" value="AMIDOHYDROLASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43794">
        <property type="entry name" value="AMINOHYDROLASE SSNA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="4">
        <location>
            <begin position="61"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0722927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="460" mass="49851" checksum="CC08AFD40C593DA4" modified="2020-08-12" version="1">MASQVDLVLIGGHVVPVVPEGVVLEKYAVVVDKGIIKDILPAADVASKYQAAETVDLKDHILIPGLVNAHTHSSMTLLRGLADDKPLCDWLVEDIFPAEGKFVSDEFVRDGTLHSAAEMIRSGTTCVNEMYFFPDAAASTFEAVGMRALVGQVVLEFPTSYASGPDDYFAKAREMFAKYKDSKLVKLSMAPHAPYTVSDPSFEKVLALSKEFNSRIHLHLHETEPECHDSETKTPSMMCHQCPEHCRPLKNMQRLGVLNDQLIAAHMTQLTDDEIAAVAAAGTHVTHCPTSNLKLASGICRVTDLLAKGVNVAIGTDGAASNNTLNMFAEMKLAAILAKAESKQSTSVPAATALRMATLNGAKALGMDHLIGSLEVGKSADIVAVSTDCIEMLPMYSAISHLVYAAGRENVSDVWVAGKRLLANRQLTTIDLSEVKSHCKKWHDEIRDHHAEMEAKKRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W8F4</accession>
    <name>A0A6G0W8F4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_018149</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000323">
        <property type="protein sequence ID" value="KAF0722797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W8F4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007039"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="428"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="457"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="6">
        <location>
            <begin position="75"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0722797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="544" mass="59819" checksum="118EE1AEC5401786" modified="2020-08-12" version="1">MVSSGFGRCIPSQHRKYIIQPRSTVPAAHLTLSRGGGGRIQADPEDCANVYHIWALGVVAVIGGQFYGWNESYETGFLPFFLAQLMMGVAYVVYIACISEVGGKVPGGSYGLARAVLGFYPGFLLGCLEILEYTSFSSVSILFVANYITDYFMWHSNYQPIMWFLFYAVFITLLESKGKYVWCFMLIFVVLCLLPAILYVFGSLPFVNLSSNGALMDLNTNTTIWATGNLDSAFFSLLPSTTVAYGGIESLTVVTGFVKEPAYSVPKGTVAAVWTLFVSNMALVLVAAALPPGLEATATDEYFLDRGLGLGLGFSPDLSQWLMLPAQMGMAFGFFIPYARLTQAMAESNLLPAFLHIQGQETTKRAMIVASAFGYFLCVVSFYSPKFQATLQNISIVAASICYATQTYGFVLLRTTYKIDTTGYKSPFGLLGAYYVWFVSFLLFLSIAGGFQGDDGIAIISTFVFVAVMTAYYRFGCQDRQTVSDEEYASIFKFSVMRFNKQRAQKRSRASAARSAVRSAVLSTRIPSLKRILSGHSQRIAIQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W8H4</accession>
    <name>A0A6G0W8H4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_017867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000314">
        <property type="protein sequence ID" value="KAF0723119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W8H4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001777"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="694"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="751"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="705"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="753"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0723119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1228" mass="137163" checksum="54F5B1394543A585" modified="2020-08-12" version="1">MLPPVYNFVHPTSPPSSRGQRRPRQESSSRKCLSMQDVDTIVAPILERWALRLHDDSKEGGADESDNSTRGKVTRLWQALLRYSSTNPRSTPREQPNAACTAIFMEILVELLRIVLPPTSLVGTLLVGGLVHSIYQSYDNNKTFYANALYADKVYAAPDRRCSFKQRQEEKQKQLKEVGVETNNVSIDVICQLFDQLESPPSLPLLPRRSFTTLPSAPRVQCLIQCINKLPVDAKQQLAATLRSSSACIFGSPLVEKIDEDREAASSASGGGTLQTFPKPPPTSISSLSLIKKRTSHARASFLKKPVEMPSRRRLASRMPSSSLRGRLQPQQSANLDEIDPSELIDELDEIYQLVCSRDVRMYHRGVRDFKQLLHKCHGDGGGDFFDDDPGDPRQSGSKNESNNDKDGVQAVATLVQLMEWHPDALASAIQQAPHILIDVLTTHPGILKYAMVHCPNTVEIFMQLDEAAAQAWQSVVHAAHKHTLLPLLWSSNETTLEDIVPARLVHAPSASPLQVAFQWLDSHVHDVARVLLLNHDLVKRIFLAMESSPSHNHEDSTLHRQRLDVLVQMLDDLPAFLDKTQRAQEAGMALALRHDIKGVVALLHGVLTHQGHLQELVASSVEVATALAMHNKQALRNLLQADVATWKPFFVHMVAEHPFLLVDSLITSTKHLPGGAELLAAYRCVMDGDTGHWLRDDDDDDVNGGKASSSSSGKARNHFSRAISVLRLTHGLRSSSARSNTLASVAETAMASSSSSSSSMNSPSKSSTRRHIDSRFPRPAASSAVVVGIYHTPWIWKTFLVDADRTQKQNPVAITPWTRRELKRFMLDMLIEKIKRDQLDYEEDDRDVGGATDLSVFVCDSLMTKFQNRSLVASHLDQLVRGMQAHIDDRRVSFFAAACGVQAPLRRGILHAWLGSLAHLLFGVLRIFEPKKRLQQLVDGSCVVPVSAVIAAAHSIFAKTLASDEMDTLVDAISNLHRFRPSDSADDQDLSAVDLDAAMDIFLHEWQRLDAQMDEQFVVAFHRFRRANQQVIGMDQFVKIITSVTRHRVSVRDCRLIFYDTGKDMMDLDTLLYLTQAYDLRAALVHPKVELDDADLAQVRASIGISNVLSFEDEFQQLRACWQEIKPIVDKQLTAVHQTDETKQELKERCQAVQEALAYLESGMDHSPCMATAWETFRHSIATLQAAVHAERSLSMVYVQCHVRKWVSKLQKRHKSQVKSTSRVTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W9E2</accession>
    <name>A0A6G0W9E2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sjoegren syndrome nuclear autoantigen 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_017316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000292">
        <property type="protein sequence ID" value="KAF0723936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W9E2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016096"/>
    <dbReference type="OrthoDB" id="295355at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033362">
        <property type="entry name" value="SSNA1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28661:SF1">
        <property type="entry name" value="MICROTUBULE NUCLEATION FACTOR SSNA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28661">
        <property type="entry name" value="SJOEGREN SYNDROME NUCLEAR AUTOANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="8"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0723936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="12964" checksum="15B00B64F679AB34" modified="2020-08-12" version="1">MAQQGATLQNYNNELVKCIEDLREKREEVNRAILKEEEEKAKIQKDLTVLTDRLSKINEALARKTQARNEYDRTIQETEAAYMKILESSQTLLHVLKRETVQLTKKKQTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W9E4</accession>
    <name>A0A6G0W9E4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_017399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000295">
        <property type="protein sequence ID" value="KAF0723825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W9E4"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0723825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="66" mass="7473" checksum="C95363FA98D37BDE" modified="2020-08-12" version="1">MDSPPPQHAKSFLRKQAPGASGMVMEGENEDYDMDQDYVATARADLLVHTNFYNNFSDDFDDDDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WBV3</accession>
    <name>A0A6G0WBV3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_016729</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000266">
        <property type="protein sequence ID" value="KAF0724666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WBV3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010779"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14014">
        <property type="entry name" value="STKc_PknB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974">
        <property type="entry name" value="MIXED LINEAGE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974:SF23">
        <property type="entry name" value="TOUSLED-LIKE KINASE, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="151"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0724666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="420" mass="48284" checksum="A60DF1C599F0C389" modified="2020-08-12" version="1">MEYDDDILEIWTEYGMTIQDNQVEVVDLTMTPPSPEPKSIKKLEIPREYEHLRLQYHEEFNQLQAELQSLEQELGHKRRDLDLEELYVDKVKRQPITSLEHEQTLRNLQERLVKKRSSFRAERTRHAQLQRRISIQNRSFFNDLPCLCGELQLRHVLGRGSTSEVWQAFCLPTISFVAVKLSTNLASAEQEYNNHKMIASNSSRYVVPIYSLLFTTVHDIPYAAITMEYMECDLAHFLETHRPCAPLLARHILQQIALALAYMHQNNIAHCDLKPANIMVADANGAVTLRLSDFHLSRSKTDPIIVGSMASPGYAPPEWHLLSSTHESHMAATTYEKFDVWGLGVIFFQCLFGRHPMGSFASKVELKQQMLNYTKLHDLVFPAPVADVDKAILLECLRPQWESRPTALQVLHLLSPKSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WC81</accession>
    <name>A0A6G0WC81_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RxLR effector protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_016548</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000258">
        <property type="protein sequence ID" value="KAF0724872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WC81"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026349419" description="RxLR effector protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0724872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="90" mass="9834" checksum="982C36AFF57EE0A2" modified="2020-08-12" version="1">MRVLAPLVLVASAVVAFNQPGNDAPLAMANQVPLQNSVDRALLFGRKKGTRSGYAPRPGVISRIRQKFSRGGKSKEEPMMGEAMMKYMNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WCJ4</accession>
    <name>A0A6G0WCJ4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Ae201684_016395</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="VJMJ01000253">
        <property type="protein sequence ID" value="KAF0724997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WCJ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020828"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000315">
        <property type="entry name" value="Calcium-dependent protein kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="48"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF0724997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="358" mass="40356" checksum="9A45BE8507BE0F8F" modified="2020-08-12" version="1">MGCNWSMCSKPSAPSEEKDSRSSSTDISQVPVVQPVAIDRPLHFRDKYILGGALGEGSYASVKKARNKETGTMYAVKVFKKANLSPDDEKDIHSEVEILSRLKHPNVLNLIDFYSELKHYYIVTDLCEGGELFDRIAHLTYYTEKEARDLVKTLLTAIKYCHDLGIVHRDLKPENILMTDKENNSSIKIADFGFAKEVTNGLTTTCGSPEYIAPEIIARSNSEEKYGTHADIWSIGVITYVLLAGYTPFHDDNQSVLFDNIANGLYYFYSPDWDEVSQEAKDFVSWALTLDPKQRPSADDLLKDTWITQENVSVYQLSGVMEKLPMLNKRKFKAAVQATILINKLRNKSQGEDESISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WCM6</accession>
    <name>A0A6G0WCM6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_016513</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallophosphoesterase superfamily. MPPE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000254">
        <property type="protein sequence ID" value="KAF0724953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WCM6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015355"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033308">
        <property type="entry name" value="PGAP5/Cdc1/Ted1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315">
        <property type="entry name" value="METALLO PHOSPHOESTERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315:SF0">
        <property type="entry name" value="METALLOPHOSPHOESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="11">
        <location>
            <begin position="2"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0724953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="266" mass="30415" checksum="12BC7A403A58A887" modified="2020-08-12" version="1">MGDQLDEGTAVTSDSLHKDYAHRLQRLLNPRDLPIMYLIGNHDAAFGAHMTPELIRRHETAFGPSNRLIEIKGKLYLQLNTMALDKDVQDSYVVQEAMAFLDHVERQRNQTKFPPLILLTHVPLYRQNDVKCGPLRAHETGHITYEAPDFQYSEHHHVLSKSLSDRLLRTIRPHAIFSAHTHAVCSYNHSVSYQKTPIAEYTVPTFAWSMRPDPWYAVVTGHIDICALPTESQHIVSLVMLAIFYIAGLSMWWCRHRGSGDKTKVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WDU8</accession>
    <name>A0A6G0WDU8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_016032</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000240">
        <property type="protein sequence ID" value="KAF0725520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WDU8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002568"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002569"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051333">
        <property type="entry name" value="CLIP_Serine_Protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260:SF136">
        <property type="entry name" value="GH08193P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Peptidase S1" evidence="2">
        <location>
            <begin position="8"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0725520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="229" mass="24724" checksum="E6959B01AF7D529F" modified="2020-08-12" version="1">MAVAPLWITADTIQNPASIPVVKIKHMEEVVCAGVLIAPQWVLTVASCLTLMTPMAVEVENDVVNVTGQALHPLYNVARFTFNLVLLQLSRAAAARPAMLDFDVLAPRTQVVARGYANSTSPLNASSSPARDETMNGTTISNVECVETTRNLADDVVCIVSLCGVKTIGSPAVVVKNGQEAVVALLGWTWHDCTHNYMLYERIASAKSFLEPFLPDSNACAMSFQRPHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WE98</accession>
    <name>A0A6G0WE98_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_015908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000237">
        <property type="protein sequence ID" value="KAF0725575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WE98"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021164"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="30"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0725575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="325" mass="36457" checksum="65ED5B571E0F6CC2" modified="2020-08-12" version="1">MIDFTDSTQVIAYADTTEWVQATKSTVQEATLLSGGVVNYVWRLRLGDGSSVILKHFPPSLRVNPSFAFPQERIELQHTALQAVASQFTQASWSAPSPYSYDPNNFVILEEDMKGVSLFNILKEDNTQVAAEDLTWVSSALVDFLGDIQSLIVPDLSLYANSPLTPIMNGLFSRNLQLMTDWNIPDTQDWYDRAVACDLVAQSNFLYGDFWPSSILVDMDARRISIIDWELARTGHFGLDMTQMMANLALMGQGNAFKSAWANTLLRSIVDAWKTTLKPIDTHAFDFEAAYIKRVVQLSQTPHWRLDDVQTTVLKLVAQVSTTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WER4</accession>
    <name>A0A6G0WER4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_015824</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000232">
        <property type="protein sequence ID" value="KAF0725862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004381"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000289">
        <property type="entry name" value="ABC transporter G family member 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000528">
        <property type="entry name" value="ABC transporter G family member 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="430"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="465"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="509"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="546"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="579"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="665"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1079"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1112"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1152"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1191"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1221"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1321"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="70"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="743"/>
            <end position="985"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0725862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1348" mass="150909" checksum="8550596F572B55EF" modified="2020-08-12" version="1">MSPPVSAESFLAEGSENFHDMLANNLETATGKAMPQVEIRFKDLSIAADVVMATKDGANELPTLANHAKKSLMGLAKSKRVFHKDILHPVSGVFKPATMTLLLGQPSSGKSSLMKMLAGRFPMEKNITVGGSLTYNGASKEEVKKQIPQFVSYMSQRDHHFPQLTVQETMEFAHQSCGGVVPQRVLDSLVSGTPEENAQAKEIIEALYQVYPDVIVRQLGLINCKDTIVGNAMLRGVSGGERKRVTIGEMEFGMKQVSLMDEISTGLDSAATFDIVKSQRSMAKSLKKTIVVALLQPSPEVFELFDDVMIMNEGYVMYHGPRAEALSYFESFGFKCPPNRDVADFLLDLGTPQQHQYVVPGMTNVPRYPADFVVLFQESTIYRYMMEHVEGPVHPLLLHDADHHMKEMPEFQNDFKTSTMQLVRRQTKVLLRNTVFIKTRIIMVILMGLLYSTTFYQVNANVAQVMYGVIFQAILFLALGQIALLPAFMDAREIFYKQRSANFYRTLSFVLAQTITQIPFSIAESVIFGTIIYWVSGFVSNVGAFFIYELILLMTNILFATWFFFIAVVSPNLHVAKPLSMVSVLFFILYAGFVIQKVDIPDYLIWIYWIDPITWAMRALSINQYMRGEFDVCNYKGVEYCATNNGKKMGVVQLESFGMPTGKEWIWYCLIYLVVLYLLFVAMSFATLEFIRYENGHGIALSEEQSKDEEEDMDYKKLPATPVGSQNADSFAVPVQSFVPVTLAFKDLHYFVPNPTKGEPELELLKGVSGYALPGTVTALMGSSGAGKTTLMDVIAGRKTGGKIVGDILLNGYKATDLAIRRCTGYCEQMDIHCESATFREALVFSSMLRQSSDIPTATKLAHAEECIRLLEMQNIADSIIRGSSVEQMKRLTIGVELAASPCVLFLDEPTSGLDARSAKIIMTGIRKIASTGRTVVCTIHQPSKEVFEMFDSLLLLKRGGETVFYGDLGDKSSHLMEYFMRIPGTPEMAPGYNPATWMLEVIGAGVETKSANTTDYVQVFQNSEEYKHLQAALAAHTQPRADVPEMNFSSKRAAANDVQFKYLLQRFMRMYWRTPSYNYTRVMLSVFLAILFGITYVSVEYTTYSGVNGGVGMVFMTTLFVGIISFNSILPLASEERASYYRERASQTYNALWYWVGSTIVEVPYVFVSTFVFTIIYYPFVGFSGSVVDVIIYGVELSLFVLMNVYFGMLMVYLTPRVDVAASLGVLLNSIFFLFMGFNPPTSQIPSGYKWLSTITPPKYSLSILVAQVFAKCDGDSGMGCKHMTQVPPVILTELGKTNVTVKEFTEFLFDMKYDNTGKYTVVVICIIIFFRVVGLLALRYMNHQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WFU3</accession>
    <name>A0A6G0WFU3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_015662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000229">
        <property type="protein sequence ID" value="KAF0725997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WFU3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006330"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF57">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="1">
        <location>
            <begin position="209"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0725997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="398" mass="45968" checksum="EACC6F1643FB4ABD" modified="2020-08-12" version="1">MTWRSRASYPVEVKLTALGLLLDHSDYAVSALMGIPRRTIRNWEKQRYEILAFEGNKQRKKISNVGHEIFPDPPALVSYMTRVRQQEKALTCLHVINWIKRHHYSWMVTYLADKPGRGYDSLLRLMQRFCDRHGFSRQRPGISKQPQHVLDSVHQGFADEFHREYAAYGKDCVYNIDETGMYYEMPPRVIWSVRGGDAKVSVGEKHGYRMTAALTIRSNGDKLPIMFVIRGRPGGRIETNEVPTYPQGHVYAVQENAWMDNEVWPKYLREVLKGEITRPSIILVDNFEAHVNEASYKIVNEELGSHLVAIPPNATSRCQPLDVGIMAPFKRHLRDLWLLEHLVDSDEMDEDELCPTAQLKRLAMIQRAIKAWDLITPEEIRASFEKALPLRVDENSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WGM9</accession>
    <name>A0A6G0WGM9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_015422</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000219">
        <property type="protein sequence ID" value="KAF0726307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WGM9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019262"/>
    <dbReference type="OrthoDB" id="9909311at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF73">
        <property type="entry name" value="PROTEIN PDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04218">
        <property type="entry name" value="CENP-B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="4">
        <location>
            <begin position="106"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0726307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="590" mass="66369" checksum="FAAD3696615907A0" modified="2020-08-12" version="1">MEMEDDSLLLLPSGEGASVDLLHANEASNEYNNTEHENPETKGRKRERLTLGQKRQVVDLASSNQFTHRELAEKFQVGRTTITNICKNTELIRNETDSADIVKKKRKTTKCTYDLKILDEALHKWRMEVKVSNPEVKMTGATLQNKAMQLAHSMLADPYIRLPEKVQAALSKFSASNGWLDGYRTRFGSFSTRLTSDQTVIKQVDFQTRLREIHHILDNVDPQDIWTGSEFALVSKPPSATQPETSRLTVSLFVNAAGETFDLQVIGTERGGGPPCDMEALDLREKYRIMYDVSKTGWQVAHTCMHVLKQLNALAKSRKRHFHVILDSAVPHVKAAMMLDSLGDQRTFFLYESLRILFLPPNFNLAKCHPLHLGLITTFKARFRYEELDALFSRCRNQASLMDPQLQWTLKNVLHWLSVALHSLEPSDIVSTWIQSGLLPSSTVASVMSYHRVSARPSKAVEDLQWLLTEIAAQMPPFLPWIGIPEANAQLWIDMEGKASVTDPGVDDVQIIRSVLVKHGYLEMRPGNLEESVEGIVSSSANVSEPVPNKRDVWEAIDLLKRYVRVSGQAPHIPSIVALNALKSSTANLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WHI3</accession>
    <name>A0A6G0WHI3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_015254</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000213">
        <property type="protein sequence ID" value="KAF0726634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WHI3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016698"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34494">
        <property type="entry name" value="PROTEIN CBG25024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34494:SF1">
        <property type="entry name" value="PROTEIN CBG25024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="2">
        <location>
            <begin position="162"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0726634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="209" mass="22450" checksum="A8C9F37BFB7E540D" modified="2020-08-12" version="1">MSSAKNPVPAASPVDTVPLISQAKSIFQALVGDVKGAAQTQDNFTKGCPVVSQARSLVERTILQDPDAASKTQQHFFSFSLDHCIGLSQAKSIVQAIRGDTEGALRTQDNFTKGCAVISQARSLVEGTILRNPEAAAKTQEYFFGQQPQKDEVDCPNPALECVVCLTGTKTVLLLPCKHLCLCQKCSAMVTAECPLCKTKIESKTDVYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WI22</accession>
    <name>A0A6G0WI22_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_014992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000205">
        <property type="protein sequence ID" value="KAF0726850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WI22"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019850"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044845">
        <property type="entry name" value="HPAT/SRGT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31485">
        <property type="entry name" value="PEPTIDYL SERINE ALPHA-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31485:SF7">
        <property type="entry name" value="PEPTIDYL SERINE ALPHA-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0726850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="852" mass="96197" checksum="AA60890300D9D843" modified="2020-08-12" version="1">MPPSPKAASVSKLTLQRWYLIGGIAFLFCFAAFVNVSFFVTNSASDLPHIRAEHHGSVDHFLQHVVFTATCSERDVMRANVLAFSAREQRFTGDLTYVAYNCDKTTFTALASKIPAAYNVSFFHAVDVQGSGDKELNPHALHAWISRYAPRVKPEEFVMIVEIDTIFTRTLDIVAMLKVADTMKNPTMLAQDAAWYDSDTPDYIMPPEILEKALGPSSRASKVEFWRGNAVHAPFVMQSRHLDATFAKTKTIYAKLDQKYQHLAYPLACAELGLEHGVAGNFRLSRYNSFAENWNVVDMIQYNPINESITTDSPLYGVYPFTMRTNTLELTKWVDGAKYVMRDLWAPLDFFHCDASLLEVPPPSLWHYAKHTYGWEQLSPILRTRHIMSISLALRAYNRAALDIKQRNCPHGFNANQEILLRENLASAVSSNLPLHGLPTEAPQEEPFHFVFTSTCSNSDQWQADMLVESFIRVNQPGSLTRIVVGCESKAQMDQVILRTQTNTRLHFASEKVKFQTHAIRHWLQETNLPHLPSRLVILSLDFLFLRQFSMNKTMPVITAYQKAEEDPNPELMEVIHGSRRPKEVHFYSGTQILQTIETKPGTIVAQNFNDYLKDLTQDSVINSLCPDCPKVEAPKTVAEVYNIGLPYVLATSDLQKSIGDACTVTEKYYAAHSPTKRSQADLVGFSMAAAKNGLSTIRLDNMAITRAASEDWNFALAKKEINSFTTIYVLANPCASDIVAPPTAAPFLRQYTRYQVNKWLADPALMPENIFACDMWLLKEPPASLWDDAIKVEDPEKIKNTYGLCTTIKLWNALLIQSRKQHCPNGFNSHKRLELVDPRPDAVVASLKKWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WK65</accession>
    <name>A0A6G0WK65_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_014290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000191">
        <property type="protein sequence ID" value="KAF0727662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WK65"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009140"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0727662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="196" mass="22321" checksum="7CDCD545FB2C8734" modified="2020-08-12" version="1">MMYATRRVYLYEDESKDRMRPDSLFMSRKQAQRQNAVKKPDVGSHHHHHAHHAHHHPHLRKKPPTRAGDDDAAWQPVFQAGCHFWQHSVTGECVADDSLKSSPCPFHEAIQPCEWNGDLGHDNDNGGGCAEQEDLEPYPACFHFLEESYTKSSQLQPGTRVLFATILRSPDTSGPIAPKSRTNPSIRHLVMRKSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WL09</accession>
    <name>A0A6G0WL09_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_014060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000184">
        <property type="protein sequence ID" value="KAF0727948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WL09"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018051"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="305"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="380"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="314"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0727948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="464" mass="52852" checksum="2138D7F07270DC4C" modified="2020-08-12" version="1">MGKVTSDEGKQDMKRSGAGERGQGMEEADLADKTEGKPSVPLIPVATTGPFPMIQDLTLDAHGYPQALSTCKVHESLFMLKAREMAMGDLWFAKTRQDCAEKWNPLVKTSGLLTECGTGHRMDFGDCQSVHNLLGLWDSQMDCSKICTTLRYLLLLYEKTGCRAALQAQWTNDRSNCKARNSVWPYVPMALFQNESVEEYLLLFALAFFTSKRGNNDYEDRPTPRTVAQWTNRLANYAEFRWNTLTRPIRSEGFQRLAQVCVLNAAAVTRKLPTLEAPYRLLPSTAIDKDGIPVRPDCSAFSLDEKRKRRRSHAVMERSQRPRVEVPSGVSKSMVEPAAPVELAPKLPSRPRSARRSPSPGVVTQDRSLVLAHVRLGMRVEDLEGQIREHQGQNRELQAQNQEMRDRLVTLEKHVANYPREDLLRELRRENEATAAQLEEMTRHVDSLWRWRKEWKSTDRRDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WL78</accession>
    <name>A0A6G0WL78_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calpain catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_014131</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000184">
        <property type="protein sequence ID" value="KAF0728025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WL78"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012983"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF379">
        <property type="entry name" value="CALPAIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="7">
        <location>
            <begin position="91"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0728025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="300" mass="33123" checksum="20C665739AA440C1" modified="2020-08-12" version="1">MPKTNLRFAKYAKKLASKKTVTKPSLLSTASLAEAIANCKAEVAAIVEECHANNRVFRDIEFDVGLDEFDCLSSLVELWDDTSSSPGGALRVRDIFKDPIFCDDGFDASDIQQGTTGNCWFLAAIASVCCVPDIVENVCVARDEKVGVYGFIFFKDGEWTHVIVDDQLLVTTTDFDHSIASAFIKDRTKFKEVLRSGSQALFFGKSSSECETWLPLLEKAYSKLHGDYKSVEGGITGEGIEDLTGGVTTSINVVDILDYDRFWTEELSRTNKDTLFSASIFRKYSTMEAMSSNGLVQTHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WLI2</accession>
    <name>A0A6G0WLI2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_013988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000181">
        <property type="protein sequence ID" value="KAF0728162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WLI2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016674"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0728162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="226" mass="25912" checksum="057AC2BA5A93D9EE" modified="2020-08-12" version="1">MDSVNEQVQRAARDLQEAIQSVRKMRQSSPFKPTTDWESIRPRDDASLWLQREYLESSDGDACEVLSITGSTLSEDDGNQEEDREGHVEHTSDERVESPRLKHQEVQPKVHPPPPLPIDAMVNHVMASMDELADLKATMTHSFHAMATRMDAFVCSVTGQAPSARIDLVQLEDMTAHWEHQLLSWQRQQRDQTERLLFSYQQQQTLIEAHRVKSNSTRSASFDLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WP63</accession>
    <name>A0A6G0WP63_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CDC20/Fizzy WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_013138</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000167">
        <property type="protein sequence ID" value="KAF0729160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WP63"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011575"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF8">
        <property type="entry name" value="FI02843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="9">
        <location>
            <begin position="165"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="288"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0729160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="479" mass="52679" checksum="ADD6DA354EE328B7" modified="2020-08-12" version="1">MEGTPRAAPSASSHNDTSKPKVLWSSAKKSKRSHSRLNASAEKENANVTKKSSLPDIDTIDIKEVEANLHSDFESVKVPRWLRKRMKMQEASAVPEPAPVSDAYAFTSTELLSAIPREHQILRPKFRPPRPDFQEIQLGSTVTDYIRQVSSLSRVLFQASNEPTQDDFYLNVLASHPSKPIVACATLQNVVLYQTKAIQRRIPISQLLPEDYITSLAWTSSSNIAVGTSDAKIHIYDVSTSTCIRTISSHEDRVGSLATADHILSSGSRDASIRHHDLRLSRATVGTSRGHSQEVCGLSYTRCGSTLASGANDNLVNLWDIKKGLSTPPQFQLSDHLAAVKALAWCPWESSLLATGGGTADRTIKCWNTRTGMLLHSTQTHAQVSALVWSCSHKELLSAHGFQSPAMTLWSYPSMQKVKSLSTRSGRILSLTTNGSHIISWCSEGTLRQWDIFLEPHAPPRSSMSDANDENAGVKLPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WP95</accession>
    <name>A0A6G0WP95_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="3">2.3.3.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_013185</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000167">
        <property type="protein sequence ID" value="KAF0729208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WP95"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003689"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010177">
        <property type="term" value="F:methylthioalkylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07940">
        <property type="entry name" value="DRE_TIM_IPMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.260:FF:000001">
        <property type="entry name" value="2-isopropylmalate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000010">
        <property type="entry name" value="2-isopropylmalate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01025">
        <property type="entry name" value="LeuA_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050073">
        <property type="entry name" value="2-IPM_HCS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054691">
        <property type="entry name" value="LeuA/HCS_post-cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005671">
        <property type="entry name" value="LeuA_bact_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00973">
        <property type="entry name" value="leuA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002086">
        <property type="entry name" value="PRK00915.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10277:SF9">
        <property type="entry name" value="2-ISOPROPYLMALATE SYNTHASE 1, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10277">
        <property type="entry name" value="HOMOCITRATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22617">
        <property type="entry name" value="HCS_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="9">
        <location>
            <begin position="32"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0729208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="573" mass="61742" checksum="189BDA1C1F946F51" modified="2020-08-12" version="1">MLAFKRASSRVSSISRAFSSATPAATAGKERLIIFDTTLRDGEQSPGATMSFHEKLQIAKGLHGMGVDVCEAGFPIASPGDFDAVSAIAQEIGPLTRASNPDFMTICGLARATEKDIQRCYDAVKHAPNHRIHLFFATSDIHLKYKLKLSRDECIRRAAEAVKFAASLSAQVEFSPEDAGRSDPDFLCDVLAEVIAAGATTLNIPDTVGYTVPDEYGALIAHLKKNTRGSEKVVFSTHCHNDLGLATANTLAGVLGGARQVEVTMNGIGERAGNTSLEEVVMTLRTRPHLYPVYTNIESTHIMKNSRMVSHYTGIAIQPNKAIVGANAFAHESGIHQDGVLKHQATYEIMLPESVGLTENRMVLGKHSGRHAYSKRLAELGYADLTPEQLDHFVEKFKVLADEKKTVTDADMEAIVNYDLYKPEPFWTLDSVHVTAGNLVKPTATVTVTFKDGTEVSEAAMGSGPIEAMFTAITRATSSGDLKLNEYTVESITDGTGALGEVTVRLSEFQTIAESGLNPQTGVSRRRQYVGHGANTDILVASASAYVNAVNRVLGTREQASRRAARNENSAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WPS6</accession>
    <name>A0A6G0WPS6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_013101</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000166">
        <property type="protein sequence ID" value="KAF0729357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WPS6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013836"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0729357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="173" mass="18528" checksum="9F4FDFFE1F662F92" modified="2020-08-12" version="1">MKTWLLSNAGRTAAKLQVVPPNALANETILARFGAAIRPMESSARMLYALEPIMHYPSIPDIQERATLLQEFVQQGLVHAVASNNPDSSTVYLSAAPSSTSLYSIDCADINDIKCLKKVNVTATSPQGLDNPFVLLEPTEVANFALSKLSSGTLQASVGYPNGEPVLLLQFPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WPY9</accession>
    <name>A0A6G0WPY9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_012975</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000164">
        <property type="protein sequence ID" value="KAF0729479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010008"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010009"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF288">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="433"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1284"/>
            <end position="1544"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="1311"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0729479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1549" mass="175719" checksum="597C0893750E98AA" modified="2020-08-12" version="1">MTAVLVLSTSSVDFKQLKGAAFMSSNDRPFVEIALLAGESTWVVYVLNDLLLPVTTHLSSLYAPLSSLLAFILTSAIASYKPFQMTASITRSCSFKTLLSGVVCTSVAVQLGCVVASYAITVAVNKSLTRPRVAAEMTQHVAIPAASDAFFATVKNSSHFAIYSIRSSLAKSDGEPTSPFFKFVKDVLTKTQDILDQQDLLPAIHLTLEAATGILQLVDDFQTNKADIECTTQLVAQITESITDCLSTRVWNENDVSFLALTLRELKSYLDGLHEESSTWMAKGIDPIVNASRIADDLKKWDDRMEKAALALNLKHQGRQDSLLNETNVAVMTSINILKEFEENLTRFDENMGNNVSKIDAFLEYFIQFQRTSELYHYEVTIHNRTANEEVFRSLEDIQRKLDQEANNQSPNQTFDLVKRLQRWMISTKNVHYDTEDLISMNQMANVYRGTYFGKPVAIKCFLGILNTDSFDLEKYVSREIRCWERASKLPYVSRLHGVCTKVSKILIVSEWCPHTVLTYLELHPSQLLTVIYELICGLSIIHECGMHHGDLKTSNVLVTMENHVAISDFGLTKSVLTSLSRANRINHSLDQRINWSSPEMVFQARRAGLPSDMWSFAMIVYQIISKQTPYQDSSSAEIMQAIKTDHDRPMRPVDLNPQLYPLWKQLKRCWLKDPQDRLTAREFKNFMEATYSVHCKDSAPGGLMIQVHSAKGLAKTSLFVELTFRGQTYMTPMTLRENKVPHWDTCFKIEANSDVDVNEKIRIRVISSGENQVLAFTTVTFEQLFEARRQNQDVSNLYYKVGFPLHPKGRAVVEAFIADENAYRRSRVIMKNICAIEVNEDFTLKSTVCILGPHASGKCTLINSLFGRYMCKTELWGGCTKTVQWIGDTLDLALQVTRVMTTYQVSSEHYGIAAWLLFARCWLFASIYNLSDMEKSVLKQDSEDIMQSFSITNVSNFYIDARAILEARRPGGKPINKELCRSWIDMLHAIREANGNPIHPSELEDIEITIHTDSDNSVLSDISTLGIYKSALPAGFYSIRSAIKIIQQSLEGIEVASSKLVTTSTSLLKLCLDIPIHREKVLTTGLLVECILVHAIHLGHLDDDSNLLSALEKIVSFWQSALTTVQTLKLHLEDTQTFEIERIGVGTDQLHQDLENVVKDLPINQNLRVTGDYEDIKCDLENLMENMQYLDKYLEAFKKNPKDRQQSDNFVELAIQIQRGFEHYKRNVALGNFSPNHNFEIEITLRQLKIQSTVSQLELPESFCWCNFESWILSSRDVIFDAYNESRLLGRGGFGTVYKGTYQGQSVAVKQINEIIMADSADFEAVVAKEIKHWNTISKHPYILTLYGVCTKAMKPIVVSELCQTNIRRYVRDWPEMLIPMIYQFALGLTTLHDANIIHRDIKGDNILVTFRGTVAIADFGLSRQALSLENTATGAREIGTLNWMSPEQYFSSRKVTVKSDVWSFGMTLWEILRNDIPFRGCTEEEFKNEIFPSETDRPEVPEEVDPSRLHLWELIKLCWQVDPGTRPSSSEIVEYLNTHYNTELEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WRY7</accession>
    <name>A0A6G0WRY7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_012192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000155">
        <property type="protein sequence ID" value="KAF0730185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WRY7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014515"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37558">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37558:SF1">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0730185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="259" mass="29531" checksum="9A060A843D7EE640" modified="2020-08-12" version="1">MLLTVKSGKMEPTTVHGRKMNLKFAFRFTPSADIDLLKEILNALPFDAPLGQIQASWDQVGARVASLHSDMLSSWGCRRRFKDLMCAFNQGKLKSLRASGTNEEIKEREELLQELSDKIGEAILHKMRRKEKKRREREQQVANDSSSEQKHKRTDKREELSDDDEDDDNDNLATLKRKLKRARTAGHKDKSVIARVSLRDASKRGKVTAQAQPKIDLDNVRRAYLSTQEESHLGLEKNDQAAKMTLLLELLKHSDLPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WS73</accession>
    <name>A0A6G0WS73_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5880 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_012277</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000155">
        <property type="protein sequence ID" value="KAF0730276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WS73"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009423"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043653">
        <property type="entry name" value="DUF5880"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19208">
        <property type="entry name" value="DUF5880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5880" evidence="2">
        <location>
            <begin position="48"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0730276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="347" mass="39300" checksum="43EDCF32390704C2" modified="2020-08-12" version="1">MANAKKRSNEESAADSVAKKAKGVTNDLLKGVNIQSIMNAEGPVVKCVLLKADGAIEQVTVDMTPSKQEVKALLGGACHFLGQYEDIEVFLMCNPEAQEDESVAMTTQKMQPPFHGRLGQIRGDILAFRTDANGEQKDFTVDEYKKFLELEIPEWEPEEDEDSEDDEDAQDEEGYKKAALAYFVEEFKEENGRDPTEEELEAITAKVEEEMKDDGDEDPRVRALEYVVAEFIEEHGRKPDEKEMETLKERVDEEMEKLVVSGEDVEEVEDLGELIKALHDEACQRYVNEHGKEPDEETKQAILKNVTRIALTLQGDGHEVDEDEDEEDDEEDEDEEGEDDDNDEDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WSL4</accession>
    <name>A0A6G0WSL4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_012123</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000154">
        <property type="protein sequence ID" value="KAF0730421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WSL4"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0730421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="117" mass="13507" checksum="779AFDDF7B3735E8" modified="2020-08-12" version="1">MHERIVESRRGIAWNRTLTETYERASSKILNLRELARASSTLEVRWTHDVTTRGLILRLEFDSAVKCSFEIKGSTSFYRHPQTAGNVFSEHFASHQNALVNAKVMFSHKSMPELQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WTC9</accession>
    <name>A0A6G0WTC9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_011857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000151">
        <property type="protein sequence ID" value="KAF0730747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WTC9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014054"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0730747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="242" mass="26422" checksum="262DE7E0766A7E68" modified="2020-08-12" version="1">MGTKSSKPWSNAENDATTNIEPFEAEAQSSATSQPPKQPSKDTNQERDQKNAESKAKRKTKKATSPADADDSSDDENLADALGTRELSIAILKPRLSDPLVLPATPPRVLAPLNPASTLTYERRTATATTSLEKALPPTQAHDRVLDAIDMDVPAVPSPQDEENETMKIIEQLMRDPPPSPLLPRPKIESKKEAVVRQAIAATRQKSEKGEKTTLKLDAADEDIMNEILLGDARRQGEDRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WU92</accession>
    <name>A0A6G0WU92_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LNS2/PITP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_011583</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lipin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000147">
        <property type="protein sequence ID" value="KAF0731033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WU92"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018974"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026058">
        <property type="entry name" value="LIPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007651">
        <property type="entry name" value="Lipin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013209">
        <property type="entry name" value="LNS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031315">
        <property type="entry name" value="LNS2/PITP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181">
        <property type="entry name" value="LIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181:SF12">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04571">
        <property type="entry name" value="Lipin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08235">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00775">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LNS2/PITP" evidence="3">
        <location>
            <begin position="174"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="443"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="443"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0731033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="466" mass="51614" checksum="75AB7D99F72C1C6C" modified="2020-08-12" version="1">MMNTSSDPPQSEKDAERNRSVSEPVKAESSPPTRRVSSDSPLNRIEKERRASGNAVDIILVKGKDGYYYSTPWHVMFSWSSFKTNAQAGVGDKIDVYVNDRKLCYTMTLMEYGRCLFRPEESSNFVPPASTWERFPLVLDGEPNFVRFEHVRDSRSYIRVVECNLYVWDPEDFAIIADLDGTITIDDVGGHIRTLRLGQYDYIHEGSCEFFTKLQSLGARILYLTARPINWASMSRVHLKEARQGDYKLPQGPVITNSLGLAGALFVEVVHKNPHIFKAGVLKQVEEAMHEGGRTSKHPVFVAGFGNRPTDVVAYKEAGVDVNCIFLINPTSTMTHSGDNSPEYESYTDPRALMWLLPKLKYKIPLEHFRKIDELTAQEIERADEIEVRRIMLQQQQAQQAAAIVEAKAAAANDAKAADATDAKAADATDAKAADATDAKAAAATDAKAAAATDATAETVVDDTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WUY9</accession>
    <name>A0A6G0WUY9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_011396</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000144">
        <property type="protein sequence ID" value="KAF0731333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WUY9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013698"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="184"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0731333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="384" mass="43334" checksum="F791B5C145B7CF45" modified="2020-08-12" version="1">MDEFQQEQMRRQAAAAAAAASSQSSYGASLFSNPQAQSMPFPTPPPPGVGMYPNDVFPSMEGASHAHPYFSHVPPPFDDVSNGGKRHAPAGRWRTPPTVYYPKSKKNTDPVTADAFADGTQGLVLDKAVLSKVLARDEADISDEHIRSIMVNKDLLNIYKKLQEEEIKRQKRLDNNRKTAQMRRKKKKGLVETYEAQVSELENILAKIRAHKFGQGDVDTLTEALSGEQRQSVNMTKDAKHQETSVLLKQHSRNASAVRQANEDNWMLTLAASNDPMFVEFKHILGLTEMQCMRLSQLQHHIHNESTRLAIVEKCFAALHVHEWLHFPHTETLVDLFRAPLSDLQLQKFVQWTRVNQPVIQQLEFAGGATNDDKDLEFEFPSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WV34</accession>
    <name>A0A6G0WV34_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_011379</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000144">
        <property type="protein sequence ID" value="KAF0731316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WV34"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013683"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026008525" description="Ig-like domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0731316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="310" mass="33894" checksum="6E0CA53B80164868" modified="2020-08-12" version="1">MQLANVLLALAAIVHAENTLTTCQSAQNAAVPCLKDSNASTTKLLDTASNQIYNFSHLNISTVENLPADAKYVDLSYNQIREINQGIPPSVAFLNLSHNALQTSWLQIPISATTVDISYNQRGLPWTAMENVWFKYLPSVSRVIYRGNDLAIVNLSYTNFPYHPHPLKALDWSDNPKLVINAAGIYNYLASHITVTADPTSYNNTLAVCENQKDTLVPIQSFPVEYSPQGDATYKPGNTTIYACSVGHFDPQAPSSASNGDGGHAAVYVVVGLVALGIVVFVIYRVTSKRRALKSTQSKDGHMNFQELKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WV87</accession>
    <name>A0A6G0WV87_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_011344</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000143">
        <property type="protein sequence ID" value="KAF0731443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WV87"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004011"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0731443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="240" mass="26782" checksum="D42EE8F6718BAD7D" modified="2020-08-12" version="1">MDMKTVEAYLLSLARPGADPGVFVCEASFEDWTRYVKSEQHALVSRAMAWKNDKIYIVEWPRGIHEGFSDYLKLAVISATGTGKVHLRPHGSSYVDNLEPIEPDCSFGPVPGIGATRPNGLSWLEYHTLTVEVGVSRSWRQLDARAVQWSQFPGVEYILLIRLSPDLEVHQYKLYSVSNGALVQPTMPPTTIDNPANIVLDSRRFLGLPVNAPFPANFTAPNLTFDLFPLVQDILFDVHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WVK8</accession>
    <name>A0A6G0WVK8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_011210</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000141">
        <property type="protein sequence ID" value="KAF0731590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WVK8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012463"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000046">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="27"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0731590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="182" mass="20652" checksum="3AA5ADAC470DCC5F" modified="2020-08-12" version="1">MPKHATPVKHENGFTINGCTFHVDKKYDPIDAIGQGSYGVVCSVLNTATKEKVAIKKITPMAGDEWDATHTLREIRLMRCLGEHENIISLKDLTMCVEKDELYMMMELADTDLHRLIQSSCPLTEGHIRVIMYQLLSGVKAMHDNGVLHRDLKPGNLLINKDCELKAINIFSSRFLIHWIDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WX18</accession>
    <name>A0A6G0WX18_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_010735</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000137">
        <property type="protein sequence ID" value="KAF0732082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WX18"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001041"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000017">
        <property type="entry name" value="Transmembrane prolyl 4-hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.780">
        <property type="entry name" value="von Hippel-Lindau disease tumour suppressor, beta domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037140">
        <property type="entry name" value="VHL_beta_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036208">
        <property type="entry name" value="VHL_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF226">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49468">
        <property type="entry name" value="VHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="7">
        <location>
            <begin position="254"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0732082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="498" mass="55742" checksum="F1AA64305976C442" modified="2020-08-12" version="1">MALAKPDKKESTNKVSYVVVFTLLTIAVTFGLLAGQIKSLVQQRHGVSGSFTKTVSVFDNGQSIGGVNITLTASQVASGAALAAYLSDFIQVEGIQLANLPPSKIVADRVYTGNGILVDTFSDFDEGERLYLVAPGLLFVWPFVRLGHKVHIKAKMSPTKKDIILESFSESPRIFHVHNFFDNEETDFLIDRILTIDDVNNKLKKSTVGHVSGANITSPHRTSENAFDQVSDVAISIRKRSFDLLRIAKYQDDMSDGLQLLRYQQKQAYIAHTDYFSPQTSLDWNWNPKTGGSNRFATVFMYLSNVSVGGQTVFPNAWMPEGHEHPPLSSETLTLANSLFGRDSWEYDMVKKCTSRLASYPRKTHAILFYNQKPSGELDPMSIHGGCPVLEGTKWAANLWVWNKHMHTVHQNRKDKIQVKFVNPTSFAVDLFWKETKMATIPAAHSLPYGSFHGHEWSFRRQDGQVLLVHKLSIEDGLAQTITLPDTRVPIAQRSDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WX88</accession>
    <name>A0A6G0WX88_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_010828</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000137">
        <property type="protein sequence ID" value="KAF0732179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WX88"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002024"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="218"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0732179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="271" mass="30668" checksum="A65566A93C4EE387" modified="2020-08-12" version="1">MLVRELKLIKQTLRDLIQSIEEGEAPLGSFALREVCQKIRRGKLSHLLLPVSSNTRTSKEQMFSSSLKKYHGNDGKPAESSEFGATNRTPMEQDSNERYGDSATLQPDIQTTSVPQASKQLNNSVQGFDPDDIDLFLGNATDCETLKEFGEFALEHSDENLLEIVGPNSTDKSFADVRNPKEEIYYSQPNTFVEETPAQSDDSPHEDADEEALKFGDWEQGFDPTTNHFYWFNNVTDESSWSPPDGWPYPLTVLTEDVEDNWQVDEPVETY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WXG8</accession>
    <name>A0A6G0WXG8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_010552</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000135">
        <property type="protein sequence ID" value="KAF0732260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WXG8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018618"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041646">
        <property type="entry name" value="VC0807_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0732260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="251" mass="28482" checksum="C679C7E4FACB39C4" modified="2020-08-12" version="1">MTESPTTQPPSEARQIFLGVLLILVINVVLPIVIFNILSPHMDDVYALLLSGVPPMMETLFRIIVQRRFDVINILAVISIGLSVALALATKDAKLAMVKDSFFTFLFGLAYWLSTYFGRENLTWYYYRQLRGPAAKEALDAMYAIEGVRRTLNFICRVWGSAMVVEALVRVALIYILSVHTMVYVSPALVWSTFVGLGIWNSWYVRYVRRKYATRTNEETVTTQVDEANPDPQVTMAEELETPKTEKIAMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WXT6</accession>
    <name>A0A6G0WXT6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_010587</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000135">
        <property type="protein sequence ID" value="KAF0732298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WXT6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005907"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
        <property type="entry name" value="FYVE_like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24121">
        <property type="entry name" value="NO MECHANORECEPTOR POTENTIAL C, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24121:SF23">
        <property type="entry name" value="NO MECHANORECEPTOR POTENTIAL C, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="278"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0732298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="355" mass="38684" checksum="E0B32A633DFE14FE" modified="2020-08-12" version="1">MRATREVEEVMEDVMASMPRSSFTKLNDSLVRLSINGDSIRKSLSLAAKWRSAGYNPFHHDSDGLTALHRAASKGDDSLAKALLSSYEGDVVKFACLGTTKQGHTALHLACKGGHLDVAMTLLDVAGKPILNCVDRHGNTALHFAATSCAPESFTLLQWLVAHAPRSLLSQPNNHGLSPVAAHIAIATADSAAMLRLFLERQVDPNAIVRGENTLLHVCVERHLYNMAGCLVEFGAALNLPDSRGVLVTDIVPDHHLGSLVKYSSRPQDWVNHVRKACMSCSRKFGFLNRRHHCRLCGRILCGKCTKNKRTLGLAEGVQTAVRVCHVCVSVLGEHRKSGSMTDVTMEVESPVMLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WXZ2</accession>
    <name>A0A6G0WXZ2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_010633</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000135">
        <property type="protein sequence ID" value="KAF0732348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WXZ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001143"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="75"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="556"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="170"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="301"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="377"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="556"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="584"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="602"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0732348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="695" mass="78157" checksum="770E834B46502C3C" modified="2020-08-12" version="1">MDASTRIMVESAQLQSRMTIPNAFHQDNTPHYRLVDSQAALKQREERDKIIREIEAKRASKRAAAKMPQPFEAALSVHGSKPRAKKAPHPDNAFRLSTSYQATTSKSLDDGEERANNTSTHEQAYIQQLEKELERLKMARQTKPVDNQVAQQLAEIKAVRLVTLSYLIAIQAQLRDLRVVEQLVREKEEAEKTIVKLKQELTKSPTKKRKYRRHVDTSTPVQNLNLSVEDDPAFDLSPGGDECLPDFDLGPRTASSVGEPPGFDDLESPKNTCQVAPKLDSKKWATPVSRPVVSPAASASTKRVNSSSKTNTVRSSAFFEAKERARREQLELEQIAREKLERAKRAAPPSGLLMNEAKLRERKQQHVEEILLEEEEKSQPFKARDPPKFDEPSDAELIEHLRKERVAARAAALLASSKVSSRLASAKKAKIIRQSPKKRIKAAPVPDFLMMQNEWKAALDRAKTKRTTTQIDQFSLTDPEKLARLQKKKQERIERQVEKEAAEVGPNRRAIEEERKMAYEKAMAAAASSSAQIAQTESQKLRTQAVQAKLKQRAAKEKAEAKAQQKREAKIKQLSKQVKAEVSTLERQRREEKGNFVDNPDEAAKAKAEESKRSFQEAIQRNKQRIMGAVAARPTLIERFAIDKKKEENKRQALAAVVSNVFGKNIGAFKGVLTDGEEDLVDAMDAQKSADEEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WZN2</accession>
    <name>A0A6G0WZN2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_010079</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000127">
        <property type="protein sequence ID" value="KAF0732974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WZN2"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0732974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="120" mass="13591" checksum="3DF7FC33522BBAA9" modified="2020-08-12" version="1">MKCRFTVNAVGNVWPTSNRGLSNRTWNDKDTRRHDLLVGSTTSHFAASFPRQHKHDNESDTRSSRHLLESNHVHSKAKQKQSWRSCSTSNMFVSWVVYLEIATLSGLSSSAHQAHDQASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X0H8</accession>
    <name>A0A6G0X0H8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Lysosomal dipeptide transporter MFSD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Major facilitator superfamily domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">Ae201684_009828</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27 28">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="23">Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79415"/>
            <dbReference type="ChEBI" id="CHEBI:192470"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)</text>
            <dbReference type="Rhea" id="RHEA:79367"/>
            <dbReference type="ChEBI" id="CHEBI:229968"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)</text>
            <dbReference type="Rhea" id="RHEA:79375"/>
            <dbReference type="ChEBI" id="CHEBI:229967"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79383"/>
            <dbReference type="ChEBI" id="CHEBI:229966"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79371"/>
            <dbReference type="ChEBI" id="CHEBI:84315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-arginyl-glycine(out) = L-arginyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79391"/>
            <dbReference type="ChEBI" id="CHEBI:229955"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79411"/>
            <dbReference type="ChEBI" id="CHEBI:229953"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79379"/>
            <dbReference type="ChEBI" id="CHEBI:229964"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-histidyl-glycine(out) = L-histidyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79395"/>
            <dbReference type="ChEBI" id="CHEBI:229957"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)</text>
            <dbReference type="Rhea" id="RHEA:79399"/>
            <dbReference type="ChEBI" id="CHEBI:229954"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79387"/>
            <dbReference type="ChEBI" id="CHEBI:229965"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79403"/>
            <dbReference type="ChEBI" id="CHEBI:229956"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-lysyl-glycine(out) = L-lysyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79407"/>
            <dbReference type="ChEBI" id="CHEBI:191202"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="24">Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000124">
        <property type="protein sequence ID" value="KAF0733265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X0H8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017761"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052187">
        <property type="entry name" value="MFSD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23512">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23512:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0458">Lysosome</keyword>
    <keyword evidence="6 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 25" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 25" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="364"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="446"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="481"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="26">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00044919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00044924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00044985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00045018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00045709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00046376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="KAF0733265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="534" mass="58161" checksum="BF7715FDF503A040" modified="2020-08-12" version="1">MEKSQLPMRWLVLFLSCTLMIGNYYCFDNPAALKSQLQQHFNDLPADRYEFLYNMLYTLYSIPNIVLPFFGGFLVDRLGARFTILLFASIITVGQIVFAIGCSTTQFNTMLFGRVIFGLGGESLGVAQSTLVASWFKNKELALALGINLSIARLGSVFNNELSPTIATDYNVSSALWVGVIMCGVSLIATLALIPIDKRVDAAITRTKKASSLPTKVSDQSMSFSDLRQFGPLFWLLSSSCMVVYGCVIPFNSVASSLLMERDFFKAPPPECVRCNEGAYKSTNCSAIVSPCPPVPPYAWPLPALTANCTFRTPEDQEKCLRGPPYVPESAINCDDKVWKYGNYSRDYCKHKAAAASAAATPMSVPYLMSAILSPFMGFAVDRIGCRALLALLAALLLVVVHLLLGLTQVTYWIPLVCQGLAYCVFAAALWPSIPYVVEPHMVGSAYGAITSIQNLGLAGFPLLVAMEYGVHNKYIPGVEMLFVAFGALGTIAGLALNILDARHGSVLNRSSIATSPAFDEHREALLDPNQTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X0R9</accession>
    <name>A0A6G0X0R9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">VTT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_009680</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000122">
        <property type="protein sequence ID" value="KAF0733434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X0R9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001786"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045014">
        <property type="entry name" value="TM41A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43220:SF21">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 41A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="7">
        <location>
            <begin position="88"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0733434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="257" mass="28502" checksum="59C7057A1F86F89C" modified="2020-08-12" version="1">MAQLLQVVKSLWRLLVVFAACIGVAYVLFQRLFARRPDLAKSLSWSMKFEDIRRGDVSAALRQAMAEDFELTIACFSCVFFIKQTFAIPGSALLNVIAGLLLPLHFAFPLVCVLTTFGASSCFLLSSSLGSHQGLVSLTDYFLPGKLDNLQTRIDAARQEKRLFFVLLFLRIFPFSPNWLLNMASPYLNIPLGLFAPSVFFGLMPYNFVTVKAGSMLSTLSSVSDIFDVQTLLGFLSLAGLILIPAIVKRRNNQKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X149</accession>
    <name>A0A6G0X149_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_009512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000121">
        <property type="protein sequence ID" value="KAF0733576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X149"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002969"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0733576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="589" mass="64783" checksum="9FB0A0FADEA7787F" modified="2020-08-12" version="1">MELISRTSRVRLEFSDDEDEEDTPRSKKAPSKAAKSGKGREESKSKPKPKYDDISMELSDDDDDDDGDEEEPEIPKTTKAANTKMMKDVDKSNEEKASSEDDETPKPAPVEQKSIASTKPVTSTLNDSSDDTPMQRWTPPPAASTMQTSKPQDQKEESDDDVDEVYSDVEDEISIADDTATEPPPASVQTEQKMEQQKIPAAATKSTNDEGAFNYSMDFSDDLDADNVEASREKSPPSIIQAPRQSTSPPPASTPAAPIVAATKGNDESAASYLDESFMEDEPPPAEPSTAAPLAPESSKDKDEYLEESFAESAEPCPSKPSEGLLARLDNPPLASTHTETSSSQNPTSSQVEPPRAAQPTEVETKLHDDGHLKTPTADIETSRRQHTSSLIVDATPPSEASSAPRTRRNIVIVREYQESRPDKVEMKDASTQYTGNHVQIQADLTPHQDAAIREEPPSTESPERTETQPPPPSMSHSRPSTMDQSSPLPFPNDVNFGTSMASVNTTLATSLYRHQLQQIQAQIRRKRLEADRVMREAMTYRYTSMDAAEKFVAVNRPRKLALWEALMQIDPLMSKEQAMKIEAMSKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X158</accession>
    <name>A0A6G0X158_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_009521</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000121">
        <property type="protein sequence ID" value="KAF0733586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X158"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003102"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0733586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="573" mass="65053" checksum="B55C740BB03C1C46" modified="2020-08-12" version="1">MEIQVVAQDAVMTFEKYRNCPLFVPGHGYNLAVVRLNPAYVPGEYFWPSFDIALVERTGPLEWRQVGGAATFTHQYVFADHLQSDDKQCSAWEMKFDLRDASTLYLWTWDPNTLYKLHIDPLHGITHVSTLSLPFNPVLKFNHGLNSYFSNDGSLLYLVSTCPWIHYEIDLDRFLFLRRSQDFMVSIETVRFGPLSHCFVVPGNASRSVLMVHHGYNSYDLHDVEHGRRAIVEFAKNDYCHIFPTSVNGEFGLLAVSSTHFTRLGDISTLVDLDCLSIPQACTTQNTDPATGQFENEEELPYDDSSEMVTLSIALEWSNPLPFPRAINVFALVIQNKTYMWRSTQWNRGHAFIIDPDSLDCVRVVSPRYEAILRSISASGHLSWDCPFLLDHRSLQQSLRESLPSHAGGLFPHEDTVADLLAADRPIGSCPLAWELVLSSPFLSIRDAVRVASVLPLAARKVAFRSGTSRCQELYTRFLDFAKMATEFAESEVDWIQDRAKSLMQFLISLEDDEAFVVLAESAYYATRGYDKDRVFAKRLLSRVKTLDSVVLHGKREVSTTIDIKSLRMQSMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X1X7</accession>
    <name>A0A6G0X1X7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_009447</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000119">
        <property type="protein sequence ID" value="KAF0733890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X1X7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001452"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0733890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="31836" checksum="CE78289C86CB3F2B" modified="2020-08-12" version="1">MAVAQAVSKRFLNVWNFVVLILGFGLLLITLYILIFQSDTYAIPKAGYWAAVICAGLLILLSGLGLYGLRQQRVCVTHNKRNYALGIYCLIGFACGVVLVVAGSVALTFNSVTYTSKELELIESAEIYFEEAMIDNLNDFATQEPEKWKQMQDNWFCCGYYDIPNVTECARRVTNKLDGATLCSKIDIPYIAMANTINSVHGVYCSTNCTDGQTVCPQTNTDWCRDVFLNNAQTNTIFVGWVSVTSGGAQLLGILLGMFILLCDVRMIRRFTMRASALKNAIENNQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X2Y1</accession>
    <name>A0A6G0X2Y1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_009009</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000117">
        <property type="protein sequence ID" value="KAF0734141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X2Y1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006639"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF31">
        <property type="entry name" value="STERYL ACETYL HYDROLASE MUG81-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="117"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0734141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="345" mass="37322" checksum="6FBAE624D8882DC3" modified="2020-08-12" version="1">MVDGTFSSKQSIPDQQFYPLSFFQTLCYVFYWIVTTPIKRLLGGKPPVDGWSIRTEIATKLLALVFSAEITSARKVNSNITYLGNLTLKTRLTPLKTDKFEAIWYGDAMDDASDANLLYIHGGAFVLCRADTNAEAITGMVSNVKTQYGKTLVALGLDYKLAPEAKFPSQLHEALAAYEYLTTRSSKPILLLGNSAGGNLVLSLLLALKLPENKHLRSPAAAAVVSPWCQLDFSNIAPSYTKNQKSDYLAAGTLSHHVGGYVGSASVKDPLVRTNLPQGYVYGGGKEVFQDDIEALVGVLKEQQVDVTAVKNPLAPHDTPMMPALYGDMALSGGQVIAAFLAKHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X468</accession>
    <name>A0A6G0X468_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_008687</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000107">
        <property type="protein sequence ID" value="KAF0734729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X468"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016156"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002259">
        <property type="entry name" value="Eqnu_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332:SF10">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01733">
        <property type="entry name" value="Nucleoside_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0734729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="381" mass="41462" checksum="1ECB8C50AAAEB149" modified="2020-08-12" version="1">MESPFLGAPESSSVANAIFAVLGFAYLFPYHAMIQPVDYWHHLFPDVNMDVLISLHYTIMAVTMLCLLVCVGGVLRYTRRIVSGLVAQVLVLGLIPAAALLDQSTWRYMSILSSSVAIAIATSFLDSSVFGLASLFPQGALEHVQFGIGLSGLFAAILRVVSKACFTATMVETATMIYFFAGAVVVVGVFVAYLILLRLPVTRHCMHTTKQSVFEVRLLRKIWRSEGLVMLTYATSFTVFPGAISTIPSFQSPWLIDSAWWQLILLTAFATMDLVGRYAARWRFGLAAHSVWRVSMRLLLVPLILCSVKGVWLTHDAISIMLVVLFAFSNGYCGTLTVVFVNDCVDASELSASGMLSSLSINLGLALGAAVGFGLSRLLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X4F2</accession>
    <name>A0A6G0X4F2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Condensation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_008593</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000106">
        <property type="protein sequence ID" value="KAF0734742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X4F2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003512"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0734742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="379" mass="41747" checksum="DAEB904BA7552929" modified="2020-08-12" version="1">MESTRLLDMEWTTAIAPSVSTITFYSGTSTSHADTKAYIQARVDAIVHANPWLTGRLKSGWFWSNLTLEFNPNPPKVIVEEAHLPELSPQLDYAKVLAACIPYEVVTGTALINSDHPAFRVTWINISDSLGALFFSLAHGVADGYTYYRLYGMLTAATPIEALTPTRFKDFPKGLNAAVKGGNDATPLFSSMPYPKSSVHDAHFQPRVDCPREDQAQGNFASWLRLHQRHYHIMGFSSMKCDVGFMAINFRGRIDGVDRKLAGNYESVLGYQPEDYTTPALIRESLAKNGFRRARSGVFPSMWRNTSAIATSWITLYEPAELPGWNMVEHLPAVAGSTPFTTTVAFFQRTPTSIGMILGARGELNVDNEAAVAPAAATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X6T4</accession>
    <name>A0A6G0X6T4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_007914</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000094">
        <property type="protein sequence ID" value="KAF0735594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X6T4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003045"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008033"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000007">
        <property type="entry name" value="Lysosomal beta glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051915">
        <property type="entry name" value="Cellulose_Degrad_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30620:SF16">
        <property type="entry name" value="LYSOSOMAL BETA GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30620">
        <property type="entry name" value="PERIPLASMIC BETA-GLUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026167855" description="beta-glucosidase" evidence="8">
        <location>
            <begin position="17"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 3 N-terminal" evidence="9">
        <location>
            <begin position="35"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0735594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="453" mass="49327" checksum="3032B9DFDFF146FE" modified="2020-08-12" version="1">MKLFIVAAIVAVTVIATPQDADLDAKAKALADKLTIEEILGQMSQIDLNAAGSQVEVDNWAQLKIGSFFNFLGVGRTGNRVVANTTELRAKMKQLQDAVIKTTNIPMIFGTDSVHGATYVHNSVLFPQSINTAATFNPELAVGLGTYMARDTKAAGIPWMFGPTLDVTRHKRWPRVYETFGEDPTVVSDMGKTVIKAIQSQGIAACFKHFITYSDPTSGLDRDNTVESSYEILNYFVPPFKAAIEADVWSGMGSFIALNSVPIAANALVHKSLLRGDLGFKGLMVTDFREINLLVSQHHYVPNTLEAVAASMNNTSYDISMVPNDDSFIKNGKQLVAQGRLSEARLRESAVRIMKLKLQLNLFDVPVPGADVESLVGDEARNTSKGTTTSSSSMSTALIVGIGAGAVCLCAIVAFFVYQRRYKRRMNDISIIGGKDDQFVIVNDRGSVTYRHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X6U0</accession>
    <name>A0A6G0X6U0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_007956</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000094">
        <property type="protein sequence ID" value="KAF0735638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X6U0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018763"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35383">
        <property type="entry name" value="MUCIN 12EA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35383:SF1">
        <property type="entry name" value="MUCIN 12EA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="940"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="750"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="771"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0735638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="981" mass="106697" checksum="516E3EC215DB07B4" modified="2020-08-12" version="1">MGFGDEGISNGASGTTGAPTTEPVTTPCPTSDEPTTDPPTTAPPTTAPPTTAPPTTAPPTTAPPTTAPPTTAPPTTAPPTTAPPTTAPPTTAPPTTAPPTTAPPTTAPPTTAPPTTAPPTTAPPTTAPPTTAPPTTAPPTTAPPTTAPPTTAPVTTPCPTTPDPATPIPTTPVVTTPCPSSPSPTAPPPTTPSPSSPTPTTEPPPPSTFPPPTTPPVCNDHFRPQSTHACPARGERDRNYIGWLKFIDRDLTKGLTQFIQSRTNNDDESCLSDECTCKDDLNAIATDWANCPLSVDNPLEPWTCLRAPFEDPSCVAAALTNNPFNTTRGLASPSLYLKPDNCRRTCAFSYTWRELWVEESPYKGRVLHCSSGIDKKPPRGGDTSGATPNQFHCEGKVSLAATGDDILVDVSVGPSASIVVHDLYIANPASVFHMPGYKDTHQTHLWLSSESWKIQDLFDVSSTVGAFNELDIPPADQVTFWRWKLENETSWHDWRANENVPLTCFATTIQFEAWTYCGAKLTDFSWTVYRHGHDRLNYLSTWFHSIWAYEKEPHCNIPHRDYSVIHLRPHPFHTNNDHDNDDGDESLEHPKFRVDSLTCRWRYESKETSQDFEVDLLSEDAFAIALQETDVTTIHVDCDVFYHDVSGKLSSTKQSRSFDFERCTDVPPATSSCRETCARGSLLNPERRRPLPGQACGGNLVYESDDATIFYNHAELACCSKCTYKTVKCLPTSIESISNCREHTKRDAYPGKTKEYSDYKPTGFPDDDDDYTKRDNDYDSDDRPGLPPTAIIIVPLPDKGINDGYNAPPQKSPYVARTPCPNDIPSAPPQYQTRPPDAPYPPANNYPWPSYPPVSNYPSPPPTTYAPSYPWNNYPPRPPINYPTPPSPPPADDYPFPPTTTYPPRPPVYVYPAANTAPSNPPANAAAFEPTQSSGSKVDAVVMGSAVAVVVVAIFVSVLIVLRMRRRQEKPPTDGNYRELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X6U2</accession>
    <name>A0A6G0X6U2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nucleolar protein 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_008027</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000095">
        <property type="protein sequence ID" value="KAF0735547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X6U2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019950"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019186">
        <property type="entry name" value="Nucleolar_protein_12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14577">
        <property type="entry name" value="NUCLEOLAR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14577:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09805">
        <property type="entry name" value="Nop25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="150"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="196"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0735547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="24011" checksum="382E1FA46EA005F5" modified="2020-08-12" version="1">MKGGSKNSKAKKSKLVVTFDADKRKEYLTGFHKRKQERRRFGHDMEAYKKKKAQIEARKIRKAEQKELLASLPEVADVKPVTTGKDVVNFDDKHTKEKFGNVVTVTTSLGELQSDSEDELDDEENELLLAAMAKKKENKEKQMSLFQRIQQKRKGIALPTKRSKIKAAKQNAKRNGGSKVVHKKGKATSDVDGKPDKRKGFHKTRKGSKFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X7M8</accession>
    <name>A0A6G0X7M8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_007849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000093">
        <property type="protein sequence ID" value="KAF0735845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X7M8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006195"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0735845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="513" mass="58282" checksum="6C624997A2B950DF" modified="2020-08-12" version="1">MPQYPPRDDSRIPSITRALQNGVNNEYQLMQSFKLSTCKKALADNVFVVINTRRRREQLVVKLMDDDLEMDFMNYMNRRNIRELFNHVVEWKDWGAITFPNNIGQCIGLVLEAGTATLENRLRESVMKEDEYAKYSCVAHLINGVKMLHAQNIIHGNISLDNILYFGDKGHFKFIDFAAATLINQPMQSMCTPEYCPPEMAKHLLNPTPEGIPAKAEYDIWSLAVVILKIFEACTLSTPQRDDLAKCLNLDPTLRASLQSLWSLLPRKTTMDANIRRVERQLMANQTTQVQLDKYKVPCLWTLQDMNPNPSGFMARGKPLLRKEIRIVCLCELRDAKPCELYDDDLPLVKANSDLSRRSGSGACRRWGGVIGDYFNFDLSKLTTIETTTAVISSVNGIVEGLPLEEKLSSIVEAMDNDSNKITEDEVQTMMTKVKDALVEFRDDPETYRKLLSMLESINFQSQSKTTIGGLERKVVRVDDVKGRRGEAADENCAGEVRWVCKAHAESLRDRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X8X5</accession>
    <name>A0A6G0X8X5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WRKY19-like zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_007354</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X8X5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020375"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056866">
        <property type="entry name" value="Znf_WRKY19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827:SF1">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24906">
        <property type="entry name" value="Zf_WRKY19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WRKY19-like zinc finger" evidence="2">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0736334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="246" mass="26747" checksum="61F5ECA794B013C8" modified="2020-08-12" version="1">MDLAIISCEPIHVSNTTSYDSVIQDLQDLNYWINLAEETSKMPPLNVDAFDVLVPYTPSSTDTESMSGDSDHDETRSRKGSFEKSMKNLSVGDMFASKPCQVPGCTQRTRRGKFCPHHGGTKCCRIPSCGNAVQSHGLCKAHGGGARCTVPGCDKSSQGGGLCRAHGGGKRCSHEGCNKGVQRGNKCATHAGFRVCRVQGCPRPDRGAGLCERHHRENQCSVAHCKRLSHALGLCKLHLRQQNRHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XA31</accession>
    <name>A0A6G0XA31_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_006787</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000085">
        <property type="protein sequence ID" value="KAF0736975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XA31"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007486"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006912">
        <property type="entry name" value="Harbinger_derived_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47150:SF5">
        <property type="entry name" value="OS07G0546750 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47150">
        <property type="entry name" value="OS12G0169200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04827">
        <property type="entry name" value="Plant_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0736975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="419" mass="47779" checksum="ADDF7EC6418AC87C" modified="2020-08-12" version="1">MNFFNIFIDDDAVEQAVAIYTQGHEDTLLWGGSRPGRAPSMERLRSVYDQLLFNDYWGPSPVYNAHYFKKHFKLPIELFDEIHELVKSNDEYFQQKPDAAGLMGISSLTKIACAVRQLTSGVSPNELDDKYRMAPSTGLETLKRFCSSIIAIYGDSVLRFPNEADLNNLLAGGLSSGFPGCIGSIDCMHWEWKNCPSGWKGMFQGKDKVPTVVLEAIADHQCRFWHFNFGSPGTLNDINILGRSPLFQKAVSGESPQIKFAVNGHDYNYAYWLTDGIYPDYACFVKTVSNPATRMQTHFASAQEAKRKDIERAFGILQARFHVLVTGCRLWSRESMAEVIETCVILHNLIIDRGQQNERDYEFGHYLIQHPFAMVRKHPRQSIGDRERMIQDMQDSNVHTQLQTDLMTSMWENYALSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XB74</accession>
    <name>A0A6G0XB74_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_006509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XB74"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000980"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0737340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="330" mass="37424" checksum="0D2A78C879CE4941" modified="2020-08-12" version="1">MINIAHPKLDRVPRTSFRFLSMNSIFTQCETPDDGPAASPCQPMYTCEVCKISMRSAKKLEDHVNHSPLHRAALNESDPTFKMEVSGKFSKESDRPTSPCRQRLIYDGTKLFWRVNETLELHIYEAINANLVTICGVNVQDKHKLPPLALDLSILQQAITNDTTSTSTSSKRDAIVKYILARVQAVKDSNGALSLYLQKQNGDKYDPTLPEPNLPKHVVSDSEPRRRHTYEEALLIQNEVHGHTRALKTSRQKAEKCHDMVRLSLDAFIDLEASVKSHPKNKNDHLSWLGALNRVRQRTDIEVIKTKLKHGHITSPTKKTVEEAQHPEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XB76</accession>
    <name>A0A6G0XB76_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_006447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XB76"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015804"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0737273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="271" mass="30557" checksum="A0731336BF65ADD4" modified="2020-08-12" version="1">MEESRKVDTQEEFPAKTPNTNETSDVEEVEEEEDTGEVDARGVPVWLKYDRQPGWHKMWEFMYKLDQPYRVGNKDMTHICLMCMEGIAKTGGSWKKALKLVGTTTIGMKHIERKHPQICHDIELARMQKKAAKAKLSTKRAPQVGLTATPEVDAAPKKKFKVLAKPLWSSQSADVDVNAVKTEIQQKIQSTATMTQQTKVQYILLAVIGCLFKHGLISSDVRSALKSQAINEPDGILLAAVELFLVDWDLDECVDTFMRVSHSVLHSEEFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XBR7</accession>
    <name>A0A6G0XBR7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Core-binding (CB) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_006717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XBR7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014771"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0737562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="38787" checksum="5BBFCF1EFAAF9464" modified="2020-08-12" version="1">MVPRRHNSFSTINGYRNAIKFLYKERNLIASKEVDETLSDFTKGYKKRVAQLKEEGEIAMVEGKTPMSKEGYVYLGEKAVRQDVKVEQYSGMHCFLLLSWNLMARALSVASVRYDHITWEGDAMVIKFGRMKNDQEGKLCYPKHVFANPKQPAICAVLSLGVLVFTRGSHRSDSSTLVFGAHAKEKFSAWVLRTCQQCENDIAALGISVTDVGTHSFRKGVSTALSSYPGGPQAVSVWLRAGWSLGNVQNRYIFAVPGGDQQCGRAAADMNTTEFATLPPHFNEASTRHPFVQCCPIYLLRSHIIMFGLVKHFTHPIHFFCHEFGRRGFFLGLPNWCTQVSFTIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XBU3</accession>
    <name>A0A6G0XBU3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_006644</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XBU3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014652"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052050">
        <property type="entry name" value="SecEffector_AnkRepeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586:SF3">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0737484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="333" mass="37020" checksum="428571484D462207" modified="2020-08-12" version="1">MTEMKRSKTTQSSTSGVLTSPDLLARILSFQFGVYKDMRAFPKLKLPIVTVPAIVRNTIDQAGINAIKTTLHPWLKTHGIGHLPRLFQCLPHMKSIVVFYAIVVGDCAVLEYMHNQFPKDFPHNTLDLAAWFSQIDVLELATKKNIQGATVSAMNMAALRGKLDVVKWLHRNRSEGCTTTAFDGAATNGHIHVVQWLHANRREGCTTTAMNGAAIHGHLHVVQWLHTHRTEGCTTDAMDSAAQKGNLDMVRWLHFHRAEGCTELALIGAAAGNHLAVVEFLYHQGYTTGRVEAAAMAKKMHNDAVYAYLAAHIARDYSTSVQNFTQMLNDRFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XC32</accession>
    <name>A0A6G0XC32_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_006305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000083">
        <property type="protein sequence ID" value="KAF0737637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XC32"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007857"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0737637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="163" mass="18073" checksum="8FE8E94A1973280F" modified="2020-08-12" version="1">MEKLSSLSFAYCIKLTKVIIESLSLQELDVTACSDLAQLRLQCPVLSSLDCSWCRHIHVKNVIVGTSVPKLSQLALRGWDPSGGSLDTQLGLLLRSFPLVCSLNLSHVALSDRGLFSVFVLANSLETLVLSQPQSNVWVDGTWTLDLLTMWKERRPNVHVVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XDP4</accession>
    <name>A0A6G0XDP4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_005871</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000077">
        <property type="protein sequence ID" value="KAF0738314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XDP4"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0738314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="106" mass="12177" checksum="981C7C66E0874321" modified="2020-08-12" version="1">MCALHGVLSHVIPCRASCRTRSPKTRHMHHLIKIVTKRRRVSKSTGRSTEMISTKWGDTRSKDVLMRNKTASGEKRVVAAVVDRDRGTVMKYKWRQGCIDQQESEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XDW1</accession>
    <name>A0A6G0XDW1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA/rRNA methyltransferase SpoU type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_006165</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0738189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XDW1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011748"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051259">
        <property type="entry name" value="rRNA_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43191:SF7">
        <property type="entry name" value="OBP33PEP LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43191">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="tRNA/rRNA methyltransferase SpoU type" evidence="3">
        <location>
            <begin position="19"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0738189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="176" mass="19319" checksum="621BC0C93DECFD30" modified="2020-08-12" version="1">MDTKHGHDKDVKANMPRQYLIINNIQKRKNIQDMLLSATAFGVVEVFVVGQKLLSFDQALNVEDVLPDFEFPFPITRFATLVECRDHLKAMDPPVTIVGIEILHNAKSINDADIFDGHTAIMAGNEGSGLSDPQIAICDRFAYIPQYGGGTASLNVTVATSIVLHSFATWANSQNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XEI0</accession>
    <name>A0A6G0XEI0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Carbonic anhydrase</fullName>
            <ecNumber evidence="4 9">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_005706</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="4 9"/>
    <dbReference type="EMBL" id="VJMJ01000074">
        <property type="protein sequence ID" value="KAF0738476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XEI0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007252"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03124">
        <property type="entry name" value="alpha_CA_prokaryotic_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041891">
        <property type="entry name" value="Alpha_CA_prokaryot-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018338">
        <property type="entry name" value="Carbonic_anhydrase_a-class_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF265">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00162">
        <property type="entry name" value="ALPHA_CA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026379699" description="Carbonic anhydrase" evidence="9">
        <location>
            <begin position="18"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0738476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="230" mass="25474" checksum="3A10D0B33A3332DF" modified="2020-08-12" version="1">MKFSFVISAIVAALTAAQNSQSPIDLPILKTVPNQANLSFLFEPAPAVIAHDNHTIKATWNAGANSHLTLNGKAYKSVQFHTHYPSEHTVSGKQYPFEVHFVHSDKDSNLAVVGVFFDVKENAEANPFMEQFLSGFSSLHKPGDNFTVASLDPSSLKLSVKNTNAYRYKGSLTTPPFTEGVEWTVLEEVQTMSTAQFDEYKHVMHETNAREVQPLNGRTVTFLAKDRAQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XEM6</accession>
    <name>A0A6G0XEM6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_005549</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000071">
        <property type="protein sequence ID" value="KAF0738621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XEM6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016189"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retroviral polymerase SH3-like" evidence="3">
        <location>
            <begin position="2"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="275"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0738621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="495" mass="55719" checksum="905F0F83B310B8D4" modified="2020-08-12" version="1">MYIGHEPDVKGYRLYCANPEKIIISRNVIFNESSCFFIDRPLSNVSELTEDSADATTAPESEDTTPAPQEPAPSVPAPSLRRSTRVRRPPTRFGTPVEDTETPRPATTTTSVPETPIIDDPGQLPPLPDSPPPSPSSSTRHDERVPTEDTQDNSPATPTMDTSNLHHHEYIPVYDEPTTSVLSPIDQHQDEPIPNFQFPPVSPRSSDVSRRRHRSIDISDDDDDPLYAKRQRILMAFALSSAGLPTTIRQAYASDERDAWIEATEAEYESLMEHNTWTLCEIPPDRKPIGCRWLFTKKFAADGSLSRYKARLVAQGFTQIAGIDYTDVFAPVIRSTSIRFFLALAAIQQMEVHHMDVQTAFLNGNLTETLYMRQPPGFIEPGNEHLVCRLNRSLYGLKQSSREWNIALDTFFREQAFVPLLCDPCIYALHSPQGLALVGVYVDDFIILCKHQGLLSRIKSDLSTRFKMKDLGQLQFCLGIEIQRPDSSTIILHQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XEV8</accession>
    <name>A0A6G0XEV8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_005379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000070">
        <property type="protein sequence ID" value="KAF0738764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XEV8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000269"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050508">
        <property type="entry name" value="Methyltransf_Superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42912">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42912:SF80">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="1">
        <location>
            <begin position="83"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0738764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="244" mass="27299" checksum="4DE3F564984D19A7" modified="2020-08-12" version="1">MAARKAAIAFAGLTVYATATFGTYIYMYDPNKGNAKPITGNERQARFDQNSGAYDKEIDFDETMTGIKLMRRFLLKNASGSILEVAAGTGRNVPYYPSGSNVLLTDLSSNMLAQIKQLPADFQTTVMSAEELTVGDGEYDTVVDTFALCSVDNPVTMLKEMQRVCKTDGKILLLEHGKSHYSWLTYILDKFALKHAERWGCFWNRDIEQIVADAGLEVETMHRFHFGTTYYIVARPKSKDPNAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XF09</accession>
    <name>A0A6G0XF09_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_005454</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000070">
        <property type="protein sequence ID" value="KAF0738843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XF09"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013230"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056552">
        <property type="entry name" value="Ribonucl_Kappa"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23489">
        <property type="entry name" value="V-ATPase_su_f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0738843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="153" mass="16847" checksum="D46C2706F9B29D0C" modified="2020-08-12" version="1">MMRLKAAVKEFEIPDMVYTARTRLGYAQLSHLTQESSPCSDTSFDTDELKGWEDLVSSNSSKGPTPHPCAILCAIISAFGFFFLLFLGSTVASNSIFIRVKPKEGNSKSSLAASIFLAAFLYLVTFVASIVSLLRARRAQKVYQLSLDIHAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XFB2</accession>
    <name>A0A6G0XFB2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_005476</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000070">
        <property type="protein sequence ID" value="KAF0738867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XFB2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003273"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050889">
        <property type="entry name" value="Dendritic_Spine_Reg/Scaffold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166:SF48">
        <property type="entry name" value="PROTEIN VAPYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166">
        <property type="entry name" value="ROLLING PEBBLES, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="38"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="71"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="104"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="137"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="170"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="205"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0738867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="314" mass="33531" checksum="79FEB387F1BE7C41" modified="2020-08-12" version="1">MGTSASKQLFDAATSNDIAKLKALLKEDIDINMTSGPEGITVLHAAAEKGHPRMVTFLLENGAEIDRKTTEGRSPLYVAAKRGHVEVVKALLEKGADIESNRKHGRTSIVIAAKKGNVEVVKYLAGRGANLEACRKDGCTPLYFAAKKGHIEVAQFLIDSKVNLEAASIDGTTPLIVAAQKGRVFMVQVLIERGANVEATRKACDACTALYVAAKKGHLRIVKLLLANGADPQVRDRILGITPLAVAAIEGHLEVVKYLLVATQAAFSSSSQDGSTLIVNAAAQTYSDVAEAIAELENPDKMFVLDKPKKAFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XFY6</accession>
    <name>A0A6G0XFY6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_005121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000066">
        <property type="protein sequence ID" value="KAF0739196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XFY6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019768"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF57">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="1">
        <location>
            <begin position="118"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0739196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="291" mass="33184" checksum="6D778B6F5B4CD474" modified="2020-08-12" version="1">MHMISYMKQHQTDWQSDYLSNKKIETAAYHSLLRLCQRFSARHRFSQRVPCVSKVRQGELNELRDDFARDFWSRFGEHCAGDIINVDETAVYYDMPPGKTLAKVGGSSKVDTSQKHSDRITAVMAVRSLDEKLPILFILRGQPGGIIETDEIPLYPPEHVYVVQESAWMDKRVWSHYLKELLKFIRGPSVIIADNLDCHVSPESEELVSTKLFSILEPLPKNSTSAFQPLDVGVSGPLKSKLRAKWLHERPVSHACEKRMAMIKRTIAAWNEMSTELVQNAFSKAIPKVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XFZ1</accession>
    <name>A0A6G0XFZ1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acyltransferase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_005078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000066">
        <property type="protein sequence ID" value="KAF0739151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XFZ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015068"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050879">
        <property type="entry name" value="Acyltransferase_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028:SF53">
        <property type="entry name" value="ACYL_TRANSF_3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="2">
        <location>
            <begin position="28"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0739151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="134" mass="15155" checksum="36AA3F13204EECFB" modified="2020-08-12" version="1">MSDDDAKVPTVQEQQEPPVKHVIVYRPDIDGLRMLAVVPVILFHAYPESFPSGFIGVDIFFVISGYLISSILFKETAKGTFTYANFYSRRIRRIYPTLLLMLSLTWWLGSLYLLSAKLKALATTMFAGTMPISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XGJ2</accession>
    <name>A0A6G0XGJ2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,3-beta-glucan synthase</fullName>
            <ecNumber evidence="3">2.4.1.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_005110</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[(1-&gt;3)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;3)-beta-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21476"/>
            <dbReference type="Rhea" id="RHEA-COMP:11146"/>
            <dbReference type="Rhea" id="RHEA-COMP:14303"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37671"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.34"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.34" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000066">
        <property type="protein sequence ID" value="KAF0739185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018824"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000148">
        <property type="term" value="C:1,3-beta-D-glucan synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003843">
        <property type="term" value="F:1,3-beta-D-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006075">
        <property type="term" value="P:(1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026899">
        <property type="entry name" value="FKS1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003440">
        <property type="entry name" value="Glyco_trans_48_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741:SF48">
        <property type="entry name" value="1,3-BETA-GLUCAN SYNTHASE COMPONENT FKS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741">
        <property type="entry name" value="LYST-INTERACTING PROTEIN LIP5 DOPAMINE RESPONSIVE PROTEIN DRG-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14288">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02364">
        <property type="entry name" value="Glucan_synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01205">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="565"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="602"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="660"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1490"/>
            <end position="1508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1528"/>
            <end position="1554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1566"/>
            <end position="1584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1771"/>
            <end position="1788"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1804"/>
            <end position="1823"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1843"/>
            <end position="1862"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1868"/>
            <end position="1885"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1897"/>
            <end position="1923"/>
        </location>
    </feature>
    <feature type="domain" description="1,3-beta-glucan synthase component FKS1-like" evidence="12">
        <location>
            <begin position="213"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="155"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="739"/>
            <end position="759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0739185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1974" mass="225641" checksum="FF6A35D598F3ADCF" modified="2020-08-12" version="1">MSSSPALEAQRKLHDEAMVHMNTGVAARSNGNAEEAEKEFGVAMGLLQEGLSLTFSQEDEEASYRLTKKMSRYLDMIKGQQAKATDGIARVAKFNILDMDNLPIRYSTVATLLKSSPTHGDIFDSLKKIHGFQENNAKNQREHLTMLLTNIKEQLETPPPLQDDKKKSKLPTIEPPKDAEDAANQAVTKLHTRLFDNYVKWCKYLKVQPSFSKEPLADLVLFFLMWGEAGNFRQTPELLCFMYHSLAASGKSSDAPKEPGTYLATVIRPIYDEVKKDNDKKTPLGQRAPHKEIRNYDDFNEFFWTKKCLKYDAYNIKDALGSVDKKGNPKDAPKTFVETRSWLRALWSFRRIFLLNFTLFCATVGYALNMSLLCPDSPIMYGPNLGNKTQIMGKLYFNPNATSFDPFEDSSIAEDQSSQGDPTECNMPKLATCFGVTNYEVGKSFVNAPLDFKMLLAQVPFQPCVEKLSGRCACYLEMLDSCFSQSGSGQAYDLTEGNPRLMSVVTYNQSKCAPKWRESALDVINKNGAGKLNCEVCSIPTMKLPTLLPKLITQMIDLNTRKDKGPMMFGAGAALVVLFLLGEVNNRLFSAMFMGYIGRNLPVPFTAFLRYACFWIVLFFVKLLFDYTFMVKNLVETSILIWVSDETQYQQASNFMIQSSYHNILYILFLWLPAFVVFMYDAQIFYALFSVVVGSVRGFNLRIGELRSFRILRIAFKDIPKMFNVKMVQNGIETKLLQEQKDNKKDKKKKSSEEPEPTLRVQTAAYSSTLTQSSEDETGSMSGRPYESVSGIDGEEFLRIIPFAMAWNRCLQSMRDADVLSNRELSVLSYLIEGKDSSERRLYPPAFLTAGKLDESLDIISECATVHKRLMSDKKKDAALAKVEKSMRKRLKKDSLRVEACMGTYKFTCRVVQQLLGEVHVEIDQCFAFVDECVLNNDVLKALNVSNLHALRMTSADLMKAILDVPKDAKEESIAFQRALYRVIDTIEQWLGQFKKVMSKQEALAQLLNDMPMKPNSFFIAPESSQQYASTQLRKLVQDAHSVSIVSRAYQLLTVDNFDAEPRSQEGQRRLRFFTNSLFMDMPHAQSLKRMHSLSISTPYYNEIVLYSIKELTEANDDSIKLLYYLQTIYPDEWEHFLERVDCKDEKEAISKIPEEVQLWASYRGQTLARTIRGMMYNEEAIKFLYWLELGNNEPMPDNGTKELDEMVALKFNYVVTCQIYGRQRDEEKQQAFDIEYLLKKHPTLRVAYVDGPKKMKEGPPKYFSCLVRSSNDKIVEVYRVELPGDPIIGEGKPENQNHAVIFSRGELIQCIDMNQDGYLEECLKMPNLLATVDRPQHAKSPLTIIGFREYVFTGAVSNLANFMQIQELSFVSLGQRMLAYNYVRQHYGHPDIFDKLFAMGTGGTAKASRGINLSEDIFAGFNTTLRGGNVSHEEFIQVGKGRDVGMQQLALFEAKLSSGAGECVTSRDVMRMANRLDLFRLQSWFYGNLGWYFTQTMTVFGVYFFIYGKMYFALSGLDAYYLQLGNLGISGVLNTSWALQFGFLLVVPVIGVVGVESGFRHGITFLFWNVLSLGPLFFTFQMGTRMHYFDRTLIHGGAKYRATGRGFTIKHEKFAELYRFYAFSHFYRGVELVFLLCLYAAYGTFSWCNCSWQIDVKFYNGQEPLPYEWEARCYANWYQQCILPTNQNYGIMSYSLWLIAATWLWAPFFFNPSGFDWDKVIADYRDWQHWLKTKNDSAESWYGWWMNELEFMEHSTGFSRFVTFVRKTRFLLLAFGIYLQLMYRLFYKDVHKTVAGGSKLKPLILAGAIFAVILLMACVSYVASRVTKKMTLKQRQLRKLKFNIAVVILIVVIGAMLYLSLSDLVEISMIIALVLYWFLQVSICRNKHDHIVMIKVAMFFDTVVGWIIFGPILIVAMFLPFISAFQQRIMFNSAFTAGLEVSKLLGHDVVASSKETYKSKTKTTKKKKKDVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XGU9</accession>
    <name>A0A6G0XGU9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">diacylglycerol O-acyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ae201684_004927</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the diacylglycerol acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.20" evidence="5"/>
    <dbReference type="EMBL" id="VJMJ01000064">
        <property type="protein sequence ID" value="KAF0739358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XGU9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010486"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007130">
        <property type="entry name" value="DAGAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317:SF0">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03982">
        <property type="entry name" value="DAGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF0739358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="175" mass="20363" checksum="12AD6EC33F16055F" modified="2020-08-12" version="1">MPIVSNVFGWAGCDSACKTNFEKCVKAGNNIAFVPGGFEEATLYEYGKHRIYIKKRAGFIKYGLQYGYKIYPSYHFGEEMTYHALTWFLPFRMWLNKFKISGVLAIGAWWCFYMPLRSAELITVVGKPIQLPTIANPTREDVEKYHKIYIDAMQDLFDRHKVKYAKDPNAKLEIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XHH4</accession>
    <name>A0A6G0XHH4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_004876</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the BBS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000063">
        <property type="protein sequence ID" value="KAF0739708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XHH4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018171"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44186">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44186:SF1">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="154"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="188"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="256"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="290"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="324"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0739708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="381" mass="43803" checksum="52CBCD1CC2828249" modified="2020-08-12" version="1">MTENASTRPLHRLEPPLTTKNYLLHKLYLRQEFAECLKLIEEMLKEHQGLCEYPIYVKALIMQHNGRIQESLQLFQAATCLNPDNKDNLKQVGRSLYLLGKHKAAIEVYEETTKLAGPDDWEIHHNIGLCHMYLKDYDQAIESFQRANNIHRHDTTYLQLGKVHTLREDFKAAINVYLEALEFSPENPELLTTIGLLYLRIGENFRAFDYLGNSMTHDPRNAKTILAAGSIIQDHSDMDVALVKYRVAAVQTPNSAQLWNNIGMCFFGKQRYVAAVASLKRALYLDPFEWITSYNLGLVHLNTGQYASAFHYFSAAINLKPDFPSSYMYLAITLGRLDDFENACSAYEKAIEMESDHLFHLNYALTLFNNDEIERAKHSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XID1</accession>
    <name>A0A6G0XID1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VPS9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_004480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000055">
        <property type="protein sequence ID" value="KAF0740038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XID1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020221"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF25">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN AND VPS9 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="2">
        <location>
            <begin position="239"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0740038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="510" mass="57958" checksum="0ED0643E65A3E852" modified="2020-08-12" version="1">MLSLPWSRQRSLKEERPEASASRTSATSTLSKALLSTERRDELLQLARNKRASWVEGTSTSSSRKRRDSVRKHPPSHVMEMMKCADDMLHFIDKMQLSPPHTKSTTKQKQDASISILEEIAARGEEKSEVPSLRMSQSFERAYSQLVDVLKHADAADLVHSIQGFIKSFQSSKRHGGGQGEKVHLFIAHFMHLMQLSPVVKKLERDRLVDDLRDSDLRREALEAFIMEKLHDAVFYSHTADDTRLKDRISALSFLSFEHLDITATSDEARWKRIQARLACLPRYLSPRRQMSCLLQVCEELTNLLKDYHGQYPGADDFLPALIYTLLKANPSHLHSTVAYIQTYRHPSKLVSEPGYFLTHLVSSLSFLEHLDDSALSITAEEFHRGLEDSKKSMAASNPSPPPPSSSSVRDSRSESADESTPTTSSSRRKKQQPPLSVLDVHNRRRKRLIPPVFSFDFASVLQSSSSTMQTFIDRSSDDIRIQEVPRLLAEYKMLNMLCAQHTILHPKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJ03</accession>
    <name>A0A6G0XJ03_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_004268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000053">
        <property type="protein sequence ID" value="KAF0740267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJ03"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019940"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0740267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="236" mass="26114" checksum="1A8B311A9AB1E1A1" modified="2020-08-12" version="1">MSQRVTRSKQKAEEGLEHTKATTSSRKVPLKAQPSLKKQPKKPTNPSPTTPTKISSDGSQDLAEGVDAYEIDLSLVKPGPPQAGGFPFTASDVLQSLSLPQLNVATFRDGHAANVHFEIEVKDEDGVRTKVVEVAVMRENDEDQYYFVAVKHALLHQYGEYIIDGPSSFKDAEAAYRKMIYVKTIEEKMPTKKRKKKPGRAKVKPQTTSTHLRSGYFLVKTGKFILCPGAVADLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJJ8</accession>
    <name>A0A6G0XJJ8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RxLR effector protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_004081</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000051">
        <property type="protein sequence ID" value="KAF0740536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJJ8"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026203597" description="RxLR effector protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0740536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="164" mass="18052" checksum="F229551D2906EDB9" modified="2020-08-12" version="1">MKVFALVLASALAVATARSADSPVMVQIKDTQTQVDVVRALAAEAQETVAKKDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDFAGDETTGANDYEHENISVVKKLEKKSGSEIQADADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJS5</accession>
    <name>A0A6G0XJS5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_004208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000052">
        <property type="protein sequence ID" value="KAF0740474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJS5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010450"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827:SF1">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0740474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="305" mass="33672" checksum="52F8F8520AAC2D27" modified="2020-08-12" version="1">MNEEPSAAPPSTQHITRQFKSQTPNHATPHFHIGLAMLVTSAQSSPSSSATCFFTNCDHPALPGSSKCSLHKHRTKCMVDRCANQVYARSLCVRHGGKKKCRFEDCHLNARIGEFCSKHGGKSYKAICIHEGCTKQAHKRKKCVRHGGGRKCNVEGCDVHARRGGFCARHGRQFSNGNLAPTSPATTDDTQVLEKVVRLPLPHQDDRSYHPPTHSHYTPQYHSTSIPTSFPPHMTRLPPPRGLHSSSFPQVVELPPPRLLPPVKAEGGQLPGLGSFMHRAPPPPMMMIIPPVTSYIDRLPRYATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XK59</accession>
    <name>A0A6G0XK59_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">SAM-dependent MTase RsmB/NOP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_003893</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000045">
        <property type="protein sequence ID" value="KAF0740762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XK59"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011823"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016428">
        <property type="term" value="F:tRNA (cytidine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000249">
        <property type="entry name" value="tRNA (Cytosine-5-)-methyltransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057285">
        <property type="entry name" value="Pre-PUA_NSUN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057286">
        <property type="entry name" value="PUA_NSUN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023270">
        <property type="entry name" value="RCMT_NCL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="RsmB/NOL1/NOP2-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808">
        <property type="entry name" value="NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808:SF1">
        <property type="entry name" value="RNA CYTOSINE-C(5)-METHYLTRANSFERASE NSUN2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25376">
        <property type="entry name" value="Pre-PUA_NSUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25378">
        <property type="entry name" value="PUA_NSUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02011">
        <property type="entry name" value="RCMTNCL1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="12">
        <location>
            <begin position="60"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="648"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="648"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="668"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="312"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="176"/>
            <end position="182"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0740762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="698" mass="78580" checksum="35D3400F307FEAC6" modified="2020-08-12" version="1">MGKRNFRKRKGQKGENTWNKKPKSEQDREAGYGEWVYKNEHFEKYYKDQAIVSEDEWDVFTKTLSLPLPTTFRINNSCAYESKIKERIATDFKYEDLVIDGEKVEPISKMPWYPEGKGFQWSIERRKIKKMELLSEFQKWLVNLSDSGDITRQEAVSMIPPLVLGVESHHKVLDMCAAPGSKTSQLLESLHDDESKTGELPTGLIVANDIDIKRAYMLTHQTKRVGSPALVITCHEAQKFPLLSSSDNKQGFFDRILCDAPCSGDGTMRKNPMIWQKWHVRNGLSLHPLQLSIVKHGASLLKVGGRMCYSTCSFNPVENEAVVAELLRWSNGSLRLIDVSNVLPKLKRRAGLTSWKVYDHDNNIVEAYDEATEATRGKYKSLPPTIFPPTAEEAEAFHLDWCMRCVPHDENTGGFFIVLIEKVGETPPESAQGKGQPKGKKHGEEYLPFNEYESIQSTYKLAPTFESSQLFTRSDTGKTVNFVTSSVSKELLPAMKTLDMKTVFAGIKVFERHDVGAGEIMYRLTQNGAHIALPHMQTRKLLVGDRDFQYLLGRRGDLVQFDEFSEQLTATLKSSPVGSYVCSLQRDDGVPLTIPEKLLLNVVIWRGRNTVNVMVDKADGFALTSTLKALNLFNDQLAIEIQEKFGKKEEAKKSAAPKDQDKAAADGNDGDEAEDAAAENGNEDDEEVNDDADDKDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XKH4</accession>
    <name>A0A6G0XKH4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_004018</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000048">
        <property type="protein sequence ID" value="KAF0740644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XKH4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009219"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04098">
        <property type="entry name" value="eEF2_C_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04090">
        <property type="entry name" value="EF2_II_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01683">
        <property type="entry name" value="EF2_IV_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16264">
        <property type="entry name" value="snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04167">
        <property type="entry name" value="Snu114p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000004">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000029">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000009">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1430.10:FF:000001">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000646">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1430.10">
        <property type="entry name" value="Yeast translation eEF2 (G' domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031950">
        <property type="entry name" value="EFTUD2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044121">
        <property type="entry name" value="Snu114_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035655">
        <property type="entry name" value="U5-116kDa_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF6">
        <property type="entry name" value="116 KDA U5 SMALL NUCLEAR RIBONUCLEOPROTEIN COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16004">
        <property type="entry name" value="EFTUD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="8">
        <location>
            <begin position="138"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="16"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0740644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1003" mass="111851" checksum="BD3DA6E2F34AED10" modified="2020-08-12" version="1">MSEPLYDEFGNYIGPDLDDDDSESEQQVESEKDEDSDNEDDDDDDDAQRPQETSSSTALQTYREEDHRIVLHEDKQYYPDAEEVYGDAEVLVMEEDAQAIETPLVAPVKVKAFSALEKEPVKTTYSNEFLASLMDFPALIRNVCVIGNLHAGKTLLLDLLVESTHVNKWKDQQKDTTKRAMTVELERRYTDTRADEQARKISIKSTPVSLVLPSSKGKSFVMNILDCPGHVNFSDEATAAMQVSDGVILMVDVIEGVMMHTETLVKAALLAKLPLLLVVNKVDRLIIELKLPPQDAYFKILHTIEEVNRIIEVHTPLGEQMKRLSPELGNVLFSSAQHGWCFSLESFSQLYAQKNPGVNPTELAKRLWGDLYYNPGARTFKSKIPYEGAHRSFVQFILEPIYKIYAQVLGEEVNVLSKTLRGLGLRLSREDLHLNPRPLLKLVLSQFLGRSASSFVDLVSRFIPSPLDTAEAKVKALYTENVKSKVAKAMIACDPTGPLMINIVKLYSSSDGTSFSAFGRIYSGAVSTGQRVKVLGESYSPDDDEDMVVRTVESVSISQGRYKVDLNRIVAGNWVLLDGVDGSITKSATITDASEELLQDDRVGIFQPISKRFSTSAVVKLAVEPLNPSELPKMLEGLRKISKSYPLVTTKVEESGEHVILCTGELSADCILHDLRNMYSEIEVKVADPVACFCETVVETSSVQCFAETPNQKNKLTMIAEPLDVGLGKDIETGVVNLSWPKKDVAEFFQNQYQWDVLAARSVWAFGPDSTGPNVLIDDTLSSEVDKKSLNSIKNSIVQGFQWGCREGPLCDEPIRNTKFKILHASMASEPIHRAGGQVIPTARRVVYSSFLTATPRLLEPMFALEIECPADTVSTLYQVLTKRRGHITHDAPKAGSPMYTVRGFLPVIESFGFETDLRVFTQGHAFCTQTFDHWALVPGDPLDTTIILRPLEPSPVQALAREFMVKTRRRKGLSEEVNVSKFFDDPMLQELAKHEMEVENLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XL11</accession>
    <name>A0A6G0XL11_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_003677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000041">
        <property type="protein sequence ID" value="KAF0741108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XL11"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001856"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0741108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="456" mass="52094" checksum="D1434855D79FA3FC" modified="2020-08-12" version="1">MNQKPRRRAARSQRVKAVCVPQSNNVDQVLLDTAQQPGAPEEDPADAMILQYFMDFTSDEKHPQVEQTTDVSAAPEKDDAALQKLRERQNKHRLNNIRHRQRKQSENDALRMEVVELEVKLQGMKALSESRKAVGARDEAAIRRSKEVSMAEKRKRVDAEEEHKILTNTIQSHRDLLQLYFKRITTSHCLQSDHLILENEPFLMYTLMGCDDVRHSGCDWIMTQMRRKTDVALTYLHSYVGNHIEEDTKIYLGENTVDLVRNHTWSFPVLQVAQSSWDSFTRVNVDPNALRKTSRLEDIDANTCYTRITIEDGIVSGRPLTLNMLQSRFMDGARAVIAFRTISEDTLHPLEGNGLCDLSVAGWLSFEPNPDGTTHARVFVKFRTDHSNGEVSQIEENIHDNRPNRKTQANQWIMSVISKMFTAVNGSARQALRTPPPATTSITFLKKTERLKDMSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XPJ8</accession>
    <name>A0A6G0XPJ8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">COMM domain-containing protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_002872</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the COMM domain-containing protein 5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000030">
        <property type="protein sequence ID" value="KAF0742207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XPJ8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000754"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017920">
        <property type="entry name" value="COMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037357">
        <property type="entry name" value="COMMD5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15666">
        <property type="entry name" value="COMM DOMAIN CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15666:SF1">
        <property type="entry name" value="COMM DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07258">
        <property type="entry name" value="COMM_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51269">
        <property type="entry name" value="COMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COMM" evidence="3">
        <location>
            <begin position="103"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00093452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0742207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="182" mass="20119" checksum="098A321D684D0DDD" modified="2020-08-12" version="1">MPDMTLADAVQGLCASMASHPQVDPCAILSSLVVVYNEPLNPSVDAGIQAVTTALRRVLESLRDGDASLNREVLQASPLPPRVVACLVDSAKQIVHTKSAIPHLNRLDWRVDLTVASNLLKTIRQPSIVLRLQLTDGHIHTIELSVDKFHELRYNTAKMLQEMNQLERHPIMRLTLDGHTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XPK4</accession>
    <name>A0A6G0XPK4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATPase AAA-type core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_002845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000030">
        <property type="protein sequence ID" value="KAF0742178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XPK4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002167"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097196">
        <property type="term" value="C:Shu complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28653">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28653:SF1">
        <property type="entry name" value="ATPASE SWSAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0742178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="32475" checksum="E8A9322E7E0B6C43" modified="2020-08-12" version="1">MERCFTHREDGSVACENVEKEVAKITSDISMMLWHGPPCSGKSSLAFQYAFDVVRAATRTDLSSDEPLPFVVLVCHESVKGKAGFVPIQPCDSCQTPVKSGRDVLHWERIRIKYLKNAAELCHFACSFHLLGGRCIALIVDDFDLFWDDSPPIPEVYRCLAFLKDTVEYMQHAHGEGQVVVVSSTSAFSKQERHRMRRWFPLLLELVPHAHANTFAMQEELPSPQPPASLILQDWAAYMPHFPVPYRIIYAFEPNSSMVHPHFIFTPRSPTKACLSFRHPPQDIAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XQP2</accession>
    <name>A0A6G0XQP2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thiamine phosphate synthase/TenI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_002507</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000026">
        <property type="protein sequence ID" value="KAF0742607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XQP2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002902"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004789">
        <property type="term" value="F:thiamine-phosphate diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00564">
        <property type="entry name" value="TMP_TenI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036206">
        <property type="entry name" value="ThiamineP_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022998">
        <property type="entry name" value="ThiamineP_synth_TenI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20857:SF23">
        <property type="entry name" value="THIAMINE BIOSYNTHETIC BIFUNCTIONAL ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20857">
        <property type="entry name" value="THIAMINE-PHOSPHATE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02581">
        <property type="entry name" value="TMP-TENI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51391">
        <property type="entry name" value="Thiamin phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0784">Thiamine biosynthesis</keyword>
    <feature type="domain" description="Thiamine phosphate synthase/TenI" evidence="3">
        <location>
            <begin position="13"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0742607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="227" mass="24659" checksum="B3475F3D150EF543" modified="2020-08-12" version="1">MTSTWRRPWLMLIVSPDDVLRGSVVREAMAGSALDVVQLRHNPATPFDKNTFMRALAALPGLGPIVQPPLYVANLPASSDLIHSVHGMDGVHYPERDLVHLKKQLRHGEPAMFGVSVHSTKSAVAAMAVGATYMQVGTMFPTASHPEKSKVEGPSLMSEIRHLLPNAQLVGVGGIDESNCTEVLRAGANGVAVIRTILQAEDPRQAAQRLRQALDEHQMLFNDHSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XRA1</accession>
    <name>A0A6G0XRA1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_002271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000023">
        <property type="protein sequence ID" value="KAF0742875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XRA1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012750"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0742875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1055" mass="116970" checksum="E2453784FD858794" modified="2020-08-12" version="1">MLSIINRRQSVAAFVLSSVLAWIATFVVEVAFPFAPSASLARTCESSNMDAQMTCNSGVIKLGSPDRFYLLFAIHFVCVAVAYALAGGRNLERQGFSKSVPVVIPTMAAHLFEREEANGMYFDAVSSFLSGFIPFHAFGYDYIFSVVLWLNFHLGTKSRGHVFRVPQLRLAPTQSPISGPSIAQLNSTSALPGINRVRLKLRAFAAVVFLIVSIASSASFFYLSREQLANDFLWAGFNSTGMQAFLIDVFNSKLQTRYGNFEIALNETNIAQSYSSTVASLLSSTLYAQTIQIEYMTVANTIRGLRTMDGCQAPWIATQYCWVDFNRTWEMASSIERQRRCQGRMPTNGAVYIESLVRNVPWLLFSSCWGDAFDVAIAATLRQSNRGREWLDRSIARTTTVADEVAFWNDYAIDCYVVQWQNYKTTGVKESFVVENALGRQYPLTLKATTGAFRFGRETSRKMYWGWASDLVAAYSMNASLIRTSAAFLFANTSIETLVLLNGTMSAPLDAGLSLVRHVLGPFGNVDMLHVPVPRSLLDFVAFFRQEDTAVLLNNATAQTTIVGSATFQPFPASWGTTYTYALGGSILCPAAAKLAMSAGLKAFVSRQSSCIGNFGESTVRRVSNHPKRVRQHDNANQSVFEQFAASPRMGPCVHADGFAPQLFVRGQTVAEDIRMLRVSIAQYVQKDQEAMQLVQAMLLDPSDPYFSLFSWYFLLDWVDGLREVISFQGDVGSMTVVSSYLPPMSSSPMALEIHTNFVSYCQLCIQYTTCALFLVTIFALAYACLSGGHIEGYNMLEINRVAGIVWVGRPLICIRSAVAILMLSTSTLTLETSGIFTRLATPERSAKENFSTFLAGNETCWLVIVVTDLAIFITKDHTTKYSLYSSLVTTSITAILSLVSPVQPSVSVVRACDAVQFDLQLTCQAGVVQIGSNQRVGDLVFTTLGVLLACFLWEKWRHPNFELPTHKLSLWLPAGAFYLYEKQPWIIHDTLYLDRVSAFMCGLLAVTHKASIYLLDIKTWRAYTIAIDPKFDARRLSTSSFDNARLADAIPMIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XRD8</accession>
    <name>A0A6G0XRD8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tyrosinase copper-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_002284</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000023">
        <property type="protein sequence ID" value="KAF0742890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XRD8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020177"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF126">
        <property type="entry name" value="TYROSINASE-LIKE PROTEIN TYR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="3">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0742890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="694" mass="77403" checksum="CE39307FDD0197F5" modified="2020-08-12" version="1">MRKCVFLDGSLRFLGIIQYSTLCSSPLAAPTANHRPHELPDTLTPIWQLSLTMTSASATPDVEKQQLVENTPLVVQEPATGVSKWTRYVAVTVILAVASVVLLSHSPKPTPAAQVPVVEDAAPVVEAEPVNLAASCGFRVRKNWDRYTPAEKARYLKAVQMAMTKGLYERFVQIHGETANNKEAHGSSCVFLLWHRKYLIGFENMLRSLSPEFACLTIPYYDYIQHAVNRLTSKCVTMEECSPILREMGGSRGTPSKAVVAGRTYTNCVAKYPLSSSCEDPTKSCNKCVPRGSWSTTNFPNIGYALIKKGLLYSNDYLEASKSIEMNPHNMVHNALKGVMMDAYMSPTEPVFFSHHATIDLLHAIYQKCKVTPLGLKGEDLYKHPKNFVGCTQPPKDPNGRVITYQTEVLMRSIYKGVPTPVDEDPELKQYFVGLPPNYAQFTDTKNLGDNSYVYEIPGLLGDLWTRCEGSDSSFDSLAKIMLNKLNLNRAKDEETVEAVTPPVLKNKVIPITRERNIAYLAWRHEIALLGREQNLTARQIDADLAKMIVYIYDKYLPGEVKDYSPEFKEMWRITEPSLSKQILDGINDGTHPIRIDGWRAVTEKYFGASICGTCNNCRYVNPTGSINACYADWTAEQCDSAGDGYTWCGDVKVTLNATCATCKNCYHPGSEACYDHWKPADCASLPNHNWCGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XS10</accession>
    <name>A0A6G0XS10_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_002205</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Folate-biopterin transporter (TC 2.A.71) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000022">
        <property type="protein sequence ID" value="KAF0743150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XS10"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015849"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039309">
        <property type="entry name" value="BT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585">
        <property type="entry name" value="FOLATE-BIOPTERIN TRANSPORTER 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585:SF5">
        <property type="entry name" value="RNA-BINDING S4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03092">
        <property type="entry name" value="BT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="354"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="504"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0743150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="543" mass="59886" checksum="092BB70234C497BA" modified="2020-08-12" version="1">MADKNLLERVSYIASLEKTSKDKEGYTDAQTPLEEGGALREGGELVYTSPEVLVLLFQYATVGIIYGTFNNLSLPILTYYFHMTPPSIASAKGLISLGWSLKVFYGMLSDCFPIMGYKRKPFILIGWTLTAISLIIIACKSAGSAVTADSPEDDRQKAQSNGSTLALLVTIACFCYIMADVSSDALVVEYAQREPEHIRGRLQSMIYSVRYIFQGVAAAIIGFLMNSPRYGGKFGFDISINVLFVIVAVPVVLNIFCVYFFLKDNKREPVQFGFYFRNLFKLVKTRAMWQVMIFQFLFNFFSVSILSNASYYIQVYWAKVEPINSAIASVLTNLVFSCSLAAMSRWGTNWNWRFVLVVATLGAGCIDAICQFCTIYDVVRSQWFYLGVPLTEQLPLGMQFVVGAYVIVELAEEGNEGVIYGLLTTIGNLPATFGTIVTNVYSAHLHITEDDISSDSSEARHDAMVSYVIVYCSMIVACVTTLLLPKQKQFVHDLKRTGGESALVGGFVLLACFAILVVSITGSLLSMFESTSCYLLAGGTGCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XSI4</accession>
    <name>A0A6G0XSI4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">H(+)-exporting diphosphatase</fullName>
            <ecNumber evidence="2">7.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_001718</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.3.1" evidence="2"/>
    <dbReference type="EMBL" id="VJMJ01000013">
        <property type="protein sequence ID" value="KAF0743572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XSI4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012659"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009678">
        <property type="term" value="F:diphosphate hydrolysis-driven proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01129">
        <property type="entry name" value="PPase_energized_pump"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004131">
        <property type="entry name" value="PPase-energised_H-pump"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001953">
        <property type="entry name" value="PRK00733.2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001960">
        <property type="entry name" value="PRK00733.3-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01104">
        <property type="entry name" value="V_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31998">
        <property type="entry name" value="K(+)-INSENSITIVE PYROPHOSPHATE-ENERGIZED PROTON PUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03030">
        <property type="entry name" value="H_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001265">
        <property type="entry name" value="H+-PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="188"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="460"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="490"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="555"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="594"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="663"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="695"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="761"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0743572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="786" mass="82625" checksum="C590944CEE28E01B" modified="2020-08-12" version="1">MRHHSEPHQNLMEFGLHGERNATSAYAKKVDLNMPIAVITAVGFILFLISSSFRPIVLVLTFCGYGAVFSLYLCNWVLSKDDGTPDMREVSVPIREGAEGFLRIQYTAIAQIAVGLALLIFFSYFLRPNSVHASGVEKLGNVMLGLLGAISFGLGAVCSAGAGYISMWVSAQSNIRVASAARRSYGEALLICFRGGAFSAVLDITLCVAGVSILYVLLHWAFTPLVASTEIPMLMVGYGFGASFVALFMQLGGGIYTKAADVGADLVGKVEQGIPEDDPRNPAVIADLVGDMVGDCVGSSADVFESVAAEIIGAMILGGSLAKEGHVQSAVSFVFFPVVVHAFDIIVSSIGILVVTAPGPNETDPMTTLQRGYTVTLILALLAFAFSTHWLLYTESAPGAWFNFFLCGLVGMVTAYVFVKSTQYYTDYAYAPVRSIAKASTTGHGTNIITGVAVGMKSTVVPTIMVSFSVIAAYHLGASSGIGGVYNRTGGLFGTAVATMGMLSSAVFVLAMNNYGPIADNAGGIAEMSSQPEYVRDATDKLDAAGNVTKAITKGYSIGSAALACFVLFGAFMDEFSAFAGVPFTTVDIATVEVLVGGLLGTMMVFFFTGLAVAAVGDTAGEVVIEVRRQFEMYPGIMQGTQKPDYRTCVALVTKAALKQMQLPGLLAVLMPVAVGLIFRVIGEYQNKPLLGAEVLAGYLMFGTVTGIMMALFLDNVGGAWDNAKKYVELGNFGGKGSEAHKAAVTGDTVGDPFKDTAGPALHVVIKLLSTTVLVLGPLFVTHVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XSM5</accession>
    <name>A0A6G0XSM5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_001777</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000014">
        <property type="protein sequence ID" value="KAF0743516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XSM5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012102"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF512">
        <property type="entry name" value="SOBREMESA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="7">
        <location>
            <begin position="134"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="472"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="475"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0743516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="500" mass="54977" checksum="8994DA1FF427FF88" modified="2020-08-12" version="1">MKVVGGGHNAPMTYSVTSIDIWAIGFTIIIGGQFFYWNGNLVAGTVGYGFVVFFVGLAFVALGFSMAEMSSMLPFAGGVYGLSRCTIGFQAGFILGFASIWPEWEPYQPLIWFLTIASSSLLVAIGGKLYWRFILGLAVFLFLQTLIFCLGCLQYLDYGQYAGGPEYTFVGGPELWFAVFPFGVWMFSGIEALNTLCNEVRDPKTMIPRGQVACSLTVFATACSIYIVAIGLPPGLEALMGSLVIFNNCYIEMFKITDTFSTILFFPACLSSFPGLLLSSSNILASMSESKLLPYDVHTRHPTLHSPIRALLCTSTWAFATCFITAYLPDFDYTMYSVTILFSCLAFTSQCFGYAYLKRRYKTMSREFHSPLGVPGAVYAVLIFTCCAISTLVIQETNLSCTITVVCVFGALSLYYQILFFAHIANNNNAKRRSVAPRRNFVSRLFRKFSSKSSSRPHSGRHHLVSPNKVYLSDARGSAPGASQGSGAMSSMHKSLKESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XTI8</accession>
    <name>A0A6G0XTI8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_001586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XTI8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012262"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0743945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="781" mass="86870" checksum="4700BD6AED4942CE" modified="2020-08-12" version="1">MCDESIDCDGNHLVLFAVSWSVFAGVTLFFLVASLRRREDHRQPQTDYHSIEFHASCMAKRFQERPAVRLYTVERCLVETALWLDVPAFSLLPCRILLFHRTSDSLSWLRLPPWFQMGVTLAALALVIVAGMSLICRPRRLDHIFLHVVQPLVFDTLYIVSAVLFVNLATSSVDLMALLALPCSSRCWLHALAGLICLTTLYLSALSYKSRLQGQIDGIRFGFSPRNATIFTIARTAIALLYASSISLLPSMSRPGLYKTLGGLQGAAMLLLWCYNYVVQPCYGSGALFNNLRSVALAASFYLSLVVLSLGVMDDVFQASYAPWTGALASFPCILLLAGIVNAKRAALVHLPELSIPQALSSPDMRVKTTAALTLTLIDLNEWTREAVVTSLCKLDNFETAPHDDLDGRGMAYSLLAVWKLCRHAFAVPCLSPATSEAAAPFHLWHDAPRIRKSAFELQKPQLAPPHVKTLQLAFEYAVALVELPFQNARDAIATLLCEMYTQDVAPLSLTTLAAMSCTLCGSSDIFMAITAAKTLDRASSLNASVALSLLADDDMSIACLLRLLGRRHEFPSPDALGDTATFLANLLRDALKQAFDLSDATDPSRGLPHDCAKLLDQAWTAWEKQYFVAAALEEICIYIHEAIVNYSSRVAVRRVLNQVQPLQPVEQQGGYRRTTTRWPQRCDKYVSATLWRQVRRRRQAKNKFASLVLQILDEGYDTRREVDAFTKRGRENLTRAMEMAAETPLVLLGHLYDSFDDCQVAYIRHLQLCMQLKGHVVPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XU20</accession>
    <name>A0A6G0XU20_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA topoisomerase 2</fullName>
            <ecNumber evidence="13">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Ae201684_001671</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12 13">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the type II topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="13"/>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0744038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XU20"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017728"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000819">
        <property type="term" value="P:sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16930">
        <property type="entry name" value="HATPase_TopII-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03481">
        <property type="entry name" value="TopoIIA_Trans_ScTopoIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03365">
        <property type="entry name" value="TOPRIM_TopoIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000113">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000097">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.670:FF:000001">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.199.10:FF:000002">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="entry name" value="Topoisomerase II, domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="entry name" value="Topoisomerase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050634">
        <property type="entry name" value="DNA_Topoisomerase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001154">
        <property type="entry name" value="TopoII_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031660">
        <property type="entry name" value="TOPRIM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034157">
        <property type="entry name" value="TOPRIM_TopoII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169:SF38">
        <property type="entry name" value="DNA TOPOISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169">
        <property type="entry name" value="DNA TOPOISOMERASE/GYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16898">
        <property type="entry name" value="TOPRIM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01158">
        <property type="entry name" value="TOPISMRASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00418">
        <property type="entry name" value="TPI2FAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="Type II DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52040">
        <property type="entry name" value="TOPO_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11 12 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12 13" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="14">
        <location>
            <begin position="474"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IIA-type catalytic" evidence="15">
        <location>
            <begin position="721"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="12">
        <location>
            <position position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS52040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF0744038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1178" mass="133137" checksum="D06E2B7AE33E8255" modified="2020-08-12" version="1">MLRILGRRGSRRIFHRLAPILQHEAPLLRREMITSRYFHKTTLLGRSDAIESMYQKKTPLEHVLLRPGMYIGSVESTKESLWIWSEKEQCMVQQTLEFVPALYKIFDEILVNAVDNKVRDESMSRLEVDIQPGNKKKPPRISIFNDGKGIPVQFHKAEQVYVPELVLGHLLTGSNFNDSTARLTGGRHGYGAKLTNIFSTEFIVETGDAKAKKRYKQVWKNNMRERGEPVIEAYDGPNFTHITFSPDLDKFHMSTLTSDMVAVLSKRVVDVAGCLPGVDVKLNGAPVHLSGFESYIQAFEGATTTDASPALYAKVNKRWEVGVLPSDVGFTQVSFVNGMTTTRGGTHVQAVLEQIVRRVADAVQTRHRDLNSLQVSQIKPHIALFVKCLIENPTFDSQMKECLTSKPEMYGSSCVLTDKFLRQVVTSSGIVERVIAAVKTKHRTALIKKVAKKAVQVPKLEDANWAGSGRANECTLILTEGDSAKALAVAGLSVVGRDSYGVFPLRGKFLNVRDATDAQLTKNSEFGHLCTILGLKPGIKYDTDDERATLRYGHVMIMTDQDHDGSHIKGLLLNLFHKFWPSLLETGYVSAFLTPLLKVHTGKEIIPFFSVPEYEAWKTEHPQQKHHVKYYKGLGTSTSKEGKEYFQALADHQVGFTWKSPEDGDALAMVFSKDRVAERKVWLSQSNPRDFIFERLSEMPLGQFVHSELIQFSHADNIRSIPNVIDGLKPSQRKVLFACFRRNLTKEMKVAQLAGYCAEHTAYHHGEASLHSTIINMAQDFVGSNNVPLLVPSGQFGTRLQGGKDAASPRYIFTYLQPHARLIFPAADEPLLNYVEDDGQTVEPEYYVPILPMLLVNGADGIGTGWSTNVPCHHPIELIDRLLERFENKDKSAPCEPWIKGFHGPVVKRENGFMTEGVIKVLHDKKKSWTLEISELPLGKSIEDYKSFLWGLVAAKKIQSFTEHHTDQTVCFHVVVLKEDSSLLNENVDWVKWFKLESNVNTTNMHAFDAAGKLQKYASSEEILDAFYPIRLELYERRKKFLVEKTSCEVKRLENRVRFVQVMVSTDSDLRSMWSSRPTKAQVVARLRAEGYDTIGALRDANDEVSDSPENDFDYLLKTSFLQFTEEYTTKLQGDLETKLRELTRLDATSAVEMWKEELLALKRALLATDPQYQYNHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XVQ8</accession>
    <name>A0A6G0XVQ8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GRIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_001073</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009483"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.60">
        <property type="entry name" value="GRIP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051952">
        <property type="entry name" value="Golgi-autophagy_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000237">
        <property type="entry name" value="GRIP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23157">
        <property type="entry name" value="GRIP AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23157:SF25">
        <property type="entry name" value="GRIP AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01465">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00755">
        <property type="entry name" value="Grip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50913">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRIP" evidence="8">
        <location>
            <begin position="1402"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="990"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1454"/>
            <end position="1531"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="218"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="350"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1215"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1315"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1000"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1489"/>
            <end position="1522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0744606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1531" mass="169569" checksum="AF07AC27A0646FEF" modified="2020-08-12" version="1">MKSAFGMKSVKKESLEKGLADMKEIGMGSLNKGLSFLRTASQSAMAAPNDEDKATRASSFNGSSDKPKMSYDELLNLSMKLTKQNKAYKAQLTQASDKLFQAGEIEANYAALVQFVSEDVGVDLVFAEIKVPPMTSEDGGDDATTSCPVEKLLDADAMRKTYHARDSTRELHVREMEEKYVHEIKQLQTELQRYTTGSSSSGDLINLDSPVKPGPSLADSKFEELEALQKELEEHKAREAEWQVKLEQSERSRAGIEQTLAEVQQQLADVRAQFADSQHRNDSFAKDIQAQAEAVRAKEEALASLKLEMQKQQQVMLKLQDKSKEISTLGPRIAVLEQEAVGHQKEIHRLQGVEVELKQALDDKNQLMTDLKAMLDQVAQEREADRAAMLAQIQSGQQLLEERQDEVDALQIQLGAAQAIAHEKQAQIDARAGSEEHIKLTLDAKATEIETLQRQLDQLRAALSDKDRQLEQEKASLESTIQRFSAEVAASKQAVDDLKATVTAKDANLAELQASVNTKSSELSQLHQLVESVRNELNDEKARSHELQITLQQRLDDVESLKAQLTAAQQAVAADANEKVVMLQEEVLREQQKVQTLTDTVHSKEKDIDSLMHRLETAEQDINSSRSNIATLEAKLQSDVAQAAATKTELEGEVSRLNTLREENAAELNRLQDALKKSEEIVQVLETNASAAQDARKALEYEISQLKTRVECDSSASKEEIVALQSALKAQKDELLASQSSVAQVAAEKAALEAQVARLAPLEDALSQLKASMAQIEQAKEAELIEVRQTIDALQDEKASTETELAQLRQEIATQTHRVAQLQEQLDHNVTNHEGDLEALLNKAQTSEEQLAKSKAHIEFLEAQLTSAQESAKAQAHDMQAYVEKVRETEQQLSTLQKEMAAQEALVADFQKKDSELLELSAKLQAVEAQAASHVADISRLENQVASHKTDLTNLQASAASTEAMKANLEAELKEMDALRQLLASKSDELSQVHTQIQSHHQERDTERQEWQDRLEASQRLADQRQAQLDRVQSQLASVQATADAYASDIQSQMVAIQQREETLVALKREMSNLTQRIAHADEKEKDAAALQTQLTAATKLAADQSVELAKLQSDLSAAREAADSALAAKANVDAELVETRAAAAKTLEAEVARLTAKFNEMEAAWNAQKNESARQAKEMHTLHKTWSEKNALAARLHAENVQLAEASAGNAAELAQLRQAFDEQSAQVSSLEALLVNAKASDEERLAEKSRLLSELQESHAAQRRIEDAAEIARREMEEGHAAALKLMQQKFAADIERIEADGRAKSKLARQMVLEKEELIASLTAKLAKLEEDVRSGDADHRRIFELASMQANREAAARSREQEFAELAAAFDQLKAENAQLAQDKIALEEDIAHLVRTERREGVNLEYLKNVVVQYMSFRPGSSQQLKLIPVLSMLLQFTPEDMEEVNSSFKHSTSWTSSWSDRKPVRNINPPPAITIPARKKVGSPRSQGSPRSSSRSSSPRSKSRRSMSPPKQRSPPVDVHDSIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XVR3</accession>
    <name>A0A6G0XVR3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_001218</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XVR3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021773"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="2">
        <location>
            <begin position="42"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="557"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="558"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0744763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="793" mass="90129" checksum="59927143EFE3E437" modified="2020-08-12" version="1">MDKIDIQRKYADHFRALGFDIPFDECLGNGNFVECNHETCSLSLEDIIRAVMATSIDLVPSHSATVYMYDRKSRMLVAKASTNAKRELDVKFAPAMGIVGRCFSRKVVVNLEQPGRDPLFEAKSDGKVNKQAESMLCVPFILEDKAIGLLQLVNRIGKKRDKLQELDRYSEGFDTLKFTADHEREVNENAFGANDIACLVEYLALVVPSLVNCIRRLDATNSVNKSGDNSGALDLINLLNGTLMSDDYEDNNPEPQEDTPEIVVVRKPRPPSKRRPPRLEHSFSIPKPTINMRETFVKAAVKCQSCGRGWLVRRQRILDKLRLERAAREEIRKAAACCIQRAFRDMRRRSQYNRKLWARSRICSAILQYISRHRGDLALPMLQEGSTLTRQVWDQTYKALLKEHAKRKHGRVTKIQKIYRGHKARTQVKKHYGASNPARIFRGFIKFQARFKGGLVRNLIQKHTIMHMTAQSNPTQRNYGIVQLTTDRRPAPSPRQLYPVSHTGANPYVVAHRGQIAHVGHLFDAHRSNTPVSKKTFPPIQNPEKVMELSSRRLVGVPSQPSSQQLPQLDRYSSTRRAVKTRDKSSPRPFPYHLDPVQHRSIKHAMSRSHCPPTNRHAFDIKQYPQYRTRSFYAAVGAVPPSPRLRPPPPSQAFLCLAQYTRDVRREGVRSALEELKRLSRARITQPTPTPRKSIKQIIEECRSIATTSPSSLPPVNVPLRRVSNPLNVPETIEDSLEEMDSVDSLALEYRPVTPMLEAIELIPPEPPFTELPLDLALEESSSSVTLFPQLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XWN8</accession>
    <name>A0A6G0XWN8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">rRNA-processing protein EFG1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">rRNA-processing protein efg1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_000532</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EFG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000003">
        <property type="protein sequence ID" value="KAF0744945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XWN8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017614"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019310">
        <property type="entry name" value="Efg1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050786">
        <property type="entry name" value="EFG1_rRNA-proc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33911">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EFG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33911:SF1">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EFG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10153">
        <property type="entry name" value="Efg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="178"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="183"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0744945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="230" mass="27253" checksum="D549685233CA0004" modified="2020-08-12" version="1">MARPTAGTILRMKKAAAKPKKKTLSLKNKIRNLERFLKKDSLPDDVRKAKEDELKELQQQSEDKKQEENSREITLKFKKVKFFDRRRLMRTLKKLKRQIESAEGKDKAKLEAEFEIARKDMMYVYFYPKGEPYINLFPDAKKPHSKEDLTRQEALKRSAVEKFNALENHAAFEHYCFNDTDLPDEKPEKRRADEDKKHKRKEKRRKTAATVVADTELDKAESDKDDDFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XWT2</accession>
    <name>A0A6G0XWT2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_000235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XWT2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004969"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="19"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="49"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0745201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="706" mass="80931" checksum="25528F91E565705F" modified="2020-08-12" version="1">MNSNCFLTLVLNSAFSLYSQRGSGPKASFPKEMSDEEMKAEAAAPTDEARQYRQALQAALQDVEDAREKLQKANQELENWKKKSGEKDDEYRELKQDVKDVDQWLQNADQRLQNAHERWKDVRAMIEKANQAIAFVHEVKVDAIRKRKAVDSHSEAKKSCLEPEMESAKRLMSAIRGCNMDQIFDIESSLDLPFPSLLAPQDRFRLKKGAFKYQARSDLKPLYDKIVRLWKEGRPITVNVAGTIGYGKSHMLAVLVLLLLKKPIENEFGSTPFVCYIPHCLDLLDEEAVVTIFQLNILLNMPDHTGQLFTIKDIRAVMQNKRVILVADQWNSIDENNPDCRMSKKRLGSCIGSSLCIDVRGMSMTSRTWRHALNRQTCDDNNLYYGGLKDEEFAVWLKHHPHIFTENKDELALLTGKVPLLLTAFARVYQVGDSWERVVQRLQQDTIVMKIDTLLKAFYDKIDSNLVRKVYTKSADLSSDVVDFRFFSGDSVRGFCAISEIVRRLVYRVWRTKTADDVLLKQWRDLVSNSPNQSTLRLDVEEIIKAKVCQQGIKRLYPNPVGRDIQKMFFGLLDESEALKLAIGKGKNEPEWMLLVPENFNYPGVDMILVTDTTLVGISVTMDKNHSKLTPFFDLWQPLAESHGMEIKGLFVAPDNFVHEEDNVETVFFKHVFPELWRVIKSNPGSTYKGKSKISNKGKHKKLQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XWZ7</accession>
    <name>A0A6G0XWZ7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">YqgE/AlgH family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_000539</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000003">
        <property type="protein sequence ID" value="KAF0744953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XWZ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017607"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1740.10">
        <property type="entry name" value="VC0467-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003774">
        <property type="entry name" value="AlgH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31984:SF17">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31984">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (DUF179)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02622">
        <property type="entry name" value="DUF179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143456">
        <property type="entry name" value="VC0467-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0744953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="33521" checksum="B34D641EDD67E40B" modified="2020-08-12" version="1">MTTRVVRAAYREVLRNAKLMDKYASIKAVMSPMEVSHNPACQRAVLHLLRQKIYYLPDASAVDVVRQMFRLPKGDIGDAFVALRYLGEKLHVARQYGLLTETQKPPTRQYGLLESPPSLSSVSITTRIRTGVFLIAHPLLRHPFEKTVVLITNHDKQGTTTGFIINEKGDKKHTLWPNYNLDADVQPLFGSHAVNFGGPVDPNSIHFLHTQPTLGGTAVGRNDPTRLFVGGDIRDFTKVPHPRPHEVVFFRGYAGWTNTMLQKELDIGSWIMTFGGISLLRSVPSTSSSLRFLGTWIFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XYC2</accession>
    <name>A0A6G0XYC2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nucleoside diphosphate kinase</fullName>
            <ecNumber evidence="9">2.7.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_000075</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="9"/>
    <dbReference type="EMBL" id="VJMJ01000001">
        <property type="protein sequence ID" value="KAF0745622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XYC2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011475"/>
    <dbReference type="OrthoDB" id="2162449at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04413">
        <property type="entry name" value="NDPk_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.141:FF:000002">
        <property type="entry name" value="Nucleoside diphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001908">
        <property type="entry name" value="PRK00668.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11349">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="10">
        <location>
            <begin position="71"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="7">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0745622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="221" mass="23811" checksum="81C003591B682B50" modified="2020-08-12" version="1">MFARRIARNVAQKATRAIATQARPLAQKSFSPLMVAAGVSGIAAGLAFGAPAEAKAVKKVSPYTGIPGTKNERTFIAIKPDGVERGLISEVIARFEKKGYKLIALKLLTPTEARAREHYADLAGRPFFNGLVKYFSSGPIVAMVWEGTDVILTGRKILGATNPNQAAPGTLRGDNCISTGRNLVHGSDGPESAKHEIGMWFTAEEIQDYERSIDEWIVADN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XYZ4</accession>
    <name>A0A6G0XYZ4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zinc/iron permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_000195</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000001">
        <property type="protein sequence ID" value="KAF0745747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XYZ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019196"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF212">
        <property type="entry name" value="ZINC_IRON PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0745747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="398" mass="43064" checksum="B3E7D4AC96555CF5" modified="2020-08-12" version="1">MMDIFWFNIVTCGLLLALTILFSLLPLFITQQSTQTTWNTILKEKLPFLTAGVFLSTGMIHLLPDAVKLYNSYLYMIGGPEEPFPFVYFLASLGCFFVWCVDSLNFGNSGEVMAVAAAAKPNYETSICRIQVPPITSFGIPRRSRTFSASDALHPNKNEELSFQYNFVNSSIRQGFVDYGTCSCDHTMLSTSGLIKLTKEHTEADVLLAGNKCAVNVERKDQCVSDPHVHVHVTGSVSEHIVFSGESTVLPYLLAALFSVHSLIAGFSLGINSELSSAALATALAIVTHKFVEAVSVGANFAKAKSSVAPHRSIAVLVTYSFMTPLGIVAGMCLNSTLQGASSKLAQAVALGIGAGSFIYLAFHEVSEKDEKHETPIFEKISLFLVGVSVMTILAVYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W2P4</accession>
    <name>A0A6G0W2P4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_019235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000535">
        <property type="protein sequence ID" value="KAF0721058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W2P4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018427"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="267"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="495"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="385"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="497"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="555"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0721058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="615" mass="65599" checksum="9A9A361892BA38AA" modified="2020-08-12" version="1" fragment="single">MSRSQSLPVQVDSSVQLESRSSAPVSRRSGVLGSVLSGMRPPPVVPGYSAKGDSYDRSSRQRPEKKQASATSDEVPPHLVVFPPAPPYLPSPVSSASSCDEWVYDCNDLYQPAIELTEREAELFGSPSSDTPGHEFEYRPNRIEARVFDPEVDNPSGFATSLHALRKMRESLPSAPEAAAPPLFHIKEEPVDSSAVASSAPDEPDVEEDEAEASVMAERFWRADVEASLTTATVDDVVMPRYLPRLGSASAPSTSAVTVGPGETGLLREEEDSKAEGSDSGTLDLGESDGDIRGSSKTLPTVMNAGPQPIKRGVLMASWERSLPDSDSLRPAAQEMVLAQRTLLQAASELHERVAEGFDQDVVRKKLRVLQQASVALSGSVVSFSANVSLEVEQLSGRLEASEKENVSLASRLTELEAQFSAVEASRVQHDQEILEKIDTINDLLGQIGTPASSAAAAPGEVSPTHEDRLRKLEETARARPQVVAKMNDRLGQLEQSSSVIPSSALPPAVPSATLEKEVQSEVVSGSATASPAGGGEDNLPSEPESEEDPSGSSQVESLPVQASNASEQPSALSGGDWDYYSRMLGISAEELKAAKDLDFEPSAKYPNRARCGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W7D3</accession>
    <name>A0A6G0W7D3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_017914</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000317">
        <property type="protein sequence ID" value="KAF0723043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W7D3"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0723043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="200" mass="22272" checksum="41F3ECC2825CA0E5" modified="2020-08-12" version="1">MIAQVETSVTVRFPSNSDIFRLSLTATSDALTIRLQSMLTLMIWESKVSNMNPREGSRSAMPFTEFASIVTAAMTLKPSAEERSVQWDLHKDTKGSLHLLVAIERSIDGEVDGFSFELMEKPMKKAVCSAMEILKSRLPRLETSALKLTFQADSRHYLKDGMLLWEKEEQSRDGGYAISDAGCEIALLKAGEYLATTLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W7L7</accession>
    <name>A0A6G0W7L7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_017861</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000313">
        <property type="protein sequence ID" value="KAF0723245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W7L7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021536"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051295">
        <property type="term" value="P:establishment of meiotic spindle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007051">
        <property type="term" value="P:spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051185">
        <property type="entry name" value="ASPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22706">
        <property type="entry name" value="ASSEMBLY FACTOR FOR SPINDLE MICROTUBULES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22706:SF1">
        <property type="entry name" value="ASSEMBLY FACTOR FOR SPINDLE MICROTUBULES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="512"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0723245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="538" mass="60619" checksum="5CD5143123C67B60" modified="2020-08-12" version="1">MGDEDRVGETPPCFTGLDETHLVYVSKNHLSSSDVVAITVTTSKRLLPNTSLKRLAVAQPKMHLLPPAAPQSLPIPRPRMNKILHAERDAYMKKLHDDRGDRIKLETWAAVKIQSLFRGHRVRPKAKPAFAHDGRTNMMASIRKELHDMQQVLPSHANSKRSEPWRQDVRLRAADKRQAKHRKDRLHHAATVIQACVKRFLARVEFIHLMSRHVDEMVLWSAIVVQAGYRGYVARKRIAERLAQVQEASATKIQCLVRGILSRERAALLRLERHSNLGQDMQREETAAATTIQRLVRGCKGRKSTAFLRDGQRMLHVQRIADGHLDERKSIAHGQTLLLIDKGVLVVEPRPSLKAPLNINTTHLHREETAAKLKTIDSGIETRHRKSYQGSRRYSGKAHVPLSLEASPLVADDARVRIDEVHAAEQRQLEARQSLALVLPKPERVEGVPSRSLLMAPPVVQSADSKFGMYAEQRPRSKRANGRPTSDTDTNAAIKIQAMARGRIVRQARRKSTAMHLRSSPTCKKVDSRANSMALPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W7N2</accession>
    <name>A0A6G0W7N2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ae201684_018357</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000331">
        <property type="protein sequence ID" value="KAF0722518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W7N2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013438"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051657">
        <property type="entry name" value="RNF168/RNF169_E3_ubiq-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23328">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23328:SF0">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="6"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF0722518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="168" mass="19151" checksum="D8D8BE775B40721A" modified="2020-08-12" version="1">MAPIQCAVCYETFHFPYTTRCGHAFCDDCLRQWTAGCGHRSCPICRARIDQVEDEPRLAHPNLDRYLVLEYVLSFEKSFYYLVSLAILVLFLASDSQRSIFEFVQDISVAMAALGATVYVLMQLCAAVDFTVVACCVGFIAQVVWYRTIYPLVSKVYQVKPFVWSRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W7S4</accession>
    <name>A0A6G0W7S4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_018295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000330">
        <property type="protein sequence ID" value="KAF0722561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W7S4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010854"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23315">
        <property type="entry name" value="U BOX DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23315:SF7">
        <property type="entry name" value="U-BOX DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0722561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="706" mass="76836" checksum="F552D76239FA7292" modified="2020-08-12" version="1">MGAGLLSKPTDPSKLDFAIARWALTADVAAWLESLGPEYTSYTAGATERNIDGPLLCSLGAHELPILIECLAITKLQHVRVISSFFDVFKTAQRAAEASVRASLGSKSTSPVKPKLTTRSKTSRSLSKPFKPPQRRSKTESHLNQTPTTCDYHAYFSYASGIDSDGKSVRDRVAAIHAALLAKDVVVWFDSEKSVASAKLIDHGLLNSTVAVIFLTRSYMNQVNSSGALAPCQYEFSSALHRHTLSRMIFCVLDDDMMRYDSLTGEFREIVGDAECMDFTKPSLLEDGCDELAETIHRLHLRYDPSVVLDDVASLGVTTLVRFLKQPTAPPDLCEQVLQTMVCQAMQPHLADKMAAKGVLPLLLTWLQPSMTTERVVELSLVLFKVLGRSHAVTRRKAAALAVEMDVLPRLLDLLKRGSRAAMENAAAVIRTVLAADEVVALLNTTSDAYQNCVVVLVSHVANEIGNLQYEAAAALCAIAMNRELQTLVVRANGIRVCLEQLANYRLDEGVRDNIALVLRHLSGSEAHQREIGSDGGVHAFLTLLDTGSSFQQETSAIALNWLMEIEENRCILVEDDGISILVEHALEGSQLLCQQAFSALAKLALHSHFHEHLADAGALEPCLRLLEQGTESQKTSACHIVAALASTEIVHEMGPVIPLIVKLLYRGSAAQKRVASATLSKLGRRKALKPAIADFVGQGSDSFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W8A6</accession>
    <name>A0A6G0W8A6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_017703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000309">
        <property type="protein sequence ID" value="KAF0723361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W8A6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006881"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0723361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="191" mass="20718" checksum="B72E714ED67AEFDE" modified="2020-08-12" version="1">MTPLNIQFAATLLGSFLDSVLQDDILEFKDVYMDVSDAIVDMLSSLALPIVVEPTMPAMEPRFLQESTTDACAHDDMADVPHIDLLNASFDEDWHLEDQDVALLQGIFDLDASTPAFATMQDPTVSPKQGPARRRRTTQCTTSSSTQRSKSSTQANKKYWLGAILFVGLCASLGPLRGATRSALGCLASSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W8V6</accession>
    <name>A0A6G0W8V6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_018327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000330">
        <property type="protein sequence ID" value="KAF0722594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W8V6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002180"/>
    <dbReference type="OrthoDB" id="70955at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0722594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="119" mass="14104" checksum="729B97962AE8B212" modified="2020-08-12" version="1">MSDTSSSPSPHVPGKRKKAVYGKEYVRQYEINRQRVLAEQREYFEQNRAKQVKSRKEHQREKRNAYQRERRRLKKLQETQKQGQMPLASHATTTSSTEYMTTNPPKQPLELNISFLLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W902</accession>
    <name>A0A6G0W902_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_017491</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000298">
        <property type="protein sequence ID" value="KAF0723640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W902"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006491"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017379"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0723640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="373" mass="42491" checksum="E811ED66E6CFFE41" modified="2020-08-12" version="1">MPSLWSQLPLEVVVKIAFSIQEAEDLLTILKTIQDEIDLGPLEHLFELGKANSNWKDLLSQLPHLTYLDVGEDYNSFGDVFEFVAMSNAITEFLAYTVQYKMTTSDVIRLTKWFRTQPVRRLELAFVDAGGVDKDVKKEFYEAMLKCETLETLNISNRGFTDIINISNRGFTDLEFIKWPLALKSLRLNLEGITSDVVKSLASQLEDSGVNHLAIVQYTDKNTEGMEHLLRVLPRTSIKHLELSHLLIDDTTWCKLAPLFESCPVSILTLHSEKIPTGFAQDFATALEKNQSICELDLDHSDIGHADLQQLIRSFSNSSRPVKRKRFKVKGPYSQPILDDEEESLKKLAAECGVKFMNRYLECRVSYSCISWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W982</accession>
    <name>A0A6G0W982_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_017426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000296">
        <property type="protein sequence ID" value="KAF0723754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W982"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017344"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0723754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="164" mass="18042" checksum="0D0851D1B4B47110" modified="2020-08-12" version="1">MDAVRGDDSVPSAQGLKRSSATVEEGNPKRSRTDNSATPTDSKQPGIEEKPSSNTMIVPAPTAAIPEPSQGELMAIHSINQKIKSLNWKLVEKELEKGMVYLGDASLSDWEAFVTSEDQQLKSKNMEWIDGKIFIVELPSQEHETYVGNCLLLSVMQLILEVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W9P8</accession>
    <name>A0A6G0W9P8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_017288</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000292">
        <property type="protein sequence ID" value="KAF0723908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W9P8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016071"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF15">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0723908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="31858" checksum="52ACEE53DFC2A258" modified="2020-08-12" version="1">MENDKVNEAATGLTPEEVDHFIKHGYVLLRNAFSTDTAAACREFLWARIEQDGVKQDDCSTWPEKHWISESYSDATGEPWTEVLTPRLKSAMDQLCGKDRWNESDLVCGWWVITFPGHAMLPWGPAGHWHVDGAHYIHKLDSKESGLLPIFIFSDINPGDGGTALAPGSHMHVAHILQDAIPHGGLKGGKVSASAKSWVYQHKKAWVEVQGRAGDIMLTHPFLMHARSKNCGSQVRFMCNPNVGLKDPMQFERDDPADYSPVEAAIVEALRQPVSQKKRKRGLHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W9W1</accession>
    <name>A0A6G0W9W1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_017498</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000298">
        <property type="protein sequence ID" value="KAF0723647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W9W1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019382"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0723647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="100" mass="11121" checksum="AC7B01BEFC6976CE" modified="2020-08-12" version="1">MKSVWSALPVDLVIKIAFALPNANDLFALLKVLRPHINLGPLESLYRLGLTHNHSDLWPSLCLKPCILSSQDCSLFKDVAQDYKNVQIKDFWSSGGSSPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WA96</accession>
    <name>A0A6G0WA96_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_017869</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000314">
        <property type="protein sequence ID" value="KAF0723121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WA96"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001775"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF214">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="317"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0723121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="580" mass="64704" checksum="E54C6B1DE0041500" modified="2020-08-12" version="1">METAGKFDLAWMLRMQSLRVVDIEHTPLQPSLPSTDDCIVTIESVGFLTMIYKLGDSVPGVGKFELPQDVYIQVNMTDGLQLILCSEFNFQGTCQSYSRNVSYKEELKSTFKSYKVVRTGDIASSQNSSDFVGCFPPVDPYIEWTPIFLQANDTVNELIYPWDQNIAKFTVPRGMVVAAFSEPFLKGDCFAWTTDADDLGHWNKSIRSLMATTTAAWSGCPLELKDQKNSTSNTSSYIQSIIQVVTTQRPSPSMESSSKSFNYLPLVIACGFGVFLFGLLVLRHAKRRNVMLETASTTMECSGLQWRDLDLYRLPPIALTHQIATGATSTIYLGKLKDQPVAIKKLTDATPDKIQTFIDEITYVTQLSSPYIVSVIGVAWTNAMDLQCVMEYMNLGDLRSYLENVKSFSWESKVSCALSVAEGLFYLHIQQLIHRDVKSRNILMDSVKGAKLGDFGPSKEVIFGDTMTAVVGTLRWMAPEMMLFKPYSSAVDIYSFGVVLSELSTHELPYASALDAKGRALSEEGIARCVIHDMMRPSFGNCPEWFSELGMKCMAQSPEDRPTAVQIIHQLKAELKALRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WAF4</accession>
    <name>A0A6G0WAF4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_017136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000281">
        <property type="protein sequence ID" value="KAF0724127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WAF4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018274"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0724127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="36821" checksum="857D3FA4BCE5F679" modified="2020-08-12" version="1">MSSNTINAEEPLRVVEEQPPLDEARHLTPVSPTWYTQEGEIRGPPGPPLSSYRGGPIRQPHGSGAPSEHGTASGAQTVVTQSMLESKLEANNATLIRQLMSMMRKTEDAKPSLPEDDGGPWDFEDEPAPVGVAEDRMWTLRLMPVEPLTIFDGEFSDRNTADTWLRKFEETSYACQWSDEETRRRFRLYTTKYVQEWVSQLEGPQKRTWRQLRQSFMKEYVQSAIDQEDLYYCSTKNRTRRSEPILSDLTLQLCELEWIIEKVGDIWIDISIALHGHYTTDPWVWPSAVNISNPSWTWRDLSIECANRKKSTNSWGRVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WAK8</accession>
    <name>A0A6G0WAK8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_016942</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000273">
        <property type="protein sequence ID" value="KAF0724277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WAK8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021521"/>
    <dbReference type="OrthoDB" id="10268793at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0724277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="148" mass="17113" checksum="E15D3A37A308E87A" modified="2020-08-12" version="1">MLLINVLDHLKHKILYHDDDMSDPLKEKTATKSRGWLYRTSSHSAKCHPTPIVLPVCCQKRLQVHRVKDPTAPSIEYKINNRAALRKHTMIVGSHHVPFYPIDNAYHRLYREDVAVLDPIDEDDFLLCEKCLHHKLSLIPPCVSISVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WAL0</accession>
    <name>A0A6G0WAL0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_016958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000273">
        <property type="protein sequence ID" value="KAF0724293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WAL0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021506"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0724293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="476" mass="52006" checksum="C102416C43D72A19" modified="2020-08-12" version="1">MEKDGSSQDGNNNAQEELSVFFNVAGLYQKIVVQEGWFVGDLIKFMAKISSNLHPHAEVPECNAIRNNQTRKFVALADPATRVLVQGNLYDLLFVDKASKTTTAPTLDLDEEIHVVFYNNPLGITMKPAGDGTYVVATKKKELNCYRRLTPGMQVVSVGGAKLTGMDFREFHTTMANSVFPLTIVFRATRESIEYLKNTPATTETLPEQTPTKPSLPPLPSTTSSSSENQVPNDTFSLPVPVVFHDDGTIESKVRRLDLKADDNSDPLSRPSATLEDEARLEQGLKSLNEAFYKKKRELNEIVERIREYTQQLTAVRVALGKYDGVDPFRSTNGSVISGTSTSSSVVQKRLPPSSTPSKLKLSSTASVSSLTSTCSIDRMAFKKSKLMGNKQRSEVSATSGRLTSKKPLNTTAFSSTLNLPSSFSTKGAVIPQAQTPRFLAPKSITPGVGHYDVKDLTKNVKGGEIGDSGRDLQWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WBS9</accession>
    <name>A0A6G0WBS9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar proton pump subunit B</fullName>
            <shortName evidence="5">V-ATPase subunit B</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Vacuolar proton pump subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_016643</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex attached to an integral membrane V0 proton pore complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000265">
        <property type="protein sequence ID" value="KAF0724712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WBS9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013653"/>
    <dbReference type="OrthoDB" id="1735853at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18112">
        <property type="entry name" value="ATP-synt_V_A-type_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18118">
        <property type="entry name" value="ATP-synt_V_A-type_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01135">
        <property type="entry name" value="V_A-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12240:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit B, brain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00310">
        <property type="entry name" value="ATP_synth_B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005723">
        <property type="entry name" value="ATPase_V1-cplx_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022879">
        <property type="entry name" value="V-ATPase_su_B/beta"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003235">
        <property type="entry name" value="PRK04196.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01040">
        <property type="entry name" value="V-ATPase_V1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389:SF4">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039114">
        <property type="entry name" value="V-ATPsynth_beta/V-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="7">
        <location>
            <begin position="36"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="6">
        <location>
            <begin position="159"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="8">
        <location>
            <begin position="390"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0724712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="508" mass="56707" checksum="28A7D72322B34DF3" modified="2020-08-12" version="1">MSHGGTKSIDLQMFEVNAKAVVRDYYVEPRIDYRTISGVNGPLVILENVKLPKFAEIVNLTLATGEVRQGQVLEVQGSKAVVQVFEGTDGIDNRHTHCEFTGDVLKMPISEEMLGRAFNGSGKAIDGAPPVVAEDYLDIQGQPINPSCRDYPKEMIQTGISAIDVMNSIARGQKIPLFSAAGLPHNEIAAQICRQAGLVQRKDVMDSHQDNFAIVFGAMGVNMETARFFRNDFEESGCMQNTALFMNLANDPTIERIITPRLALTTAEYLAYERDLHVLVILTDMSSYADALREVSAAREEVPGRRGYPGYMYTDLSTIYERAGRVMGRNGSITQLPILTMPNDDITHPIPDLTGYITEGQIYVDRQLYNRQIFPPINVLPSLSRLMKSAIGEGMTRDDHSAVSNQLYASYATGKDVQAMKAVVGEEALSMEDHLYLKFTDKFEGKFIAQGPYQSRDIFESLDLAWSLFRAFPKELLKKIPKKHLDTFYARRTQVREDLGHEEINAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WD42</accession>
    <name>A0A6G0WD42_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_016779</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000267">
        <property type="protein sequence ID" value="KAF0724571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WD42"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015768"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0724571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="393" mass="44717" checksum="CDBC25EA548B730F" modified="2020-08-12" version="1">MNAIMERWQYFMTMTDVRLLIRHQAANTLSVKMVMSTVAKSRNKERAKENRRLRKEELAYLRSRVTELSRQLHAETKMLPWQEVAHALQSESSTAQETNRALRRDIIRTTVLLECLLALVAGPMARSPETSPFVQASGWKNQAILGIDGEARVASFQWLLSRLFHNTDMAYAQCPNTPSVRIDVNYDNHYISGCRGAQYIVPAPMDQAVRTLDGLIKCDIFFDRDNPTYLYDQELLQTPNFGPSTFHFGPGNGPTYLRGSQVSPSRAVFARCRVNFDAARPGIDQKEQIHHAWLVVEPLSESTSRLLSLDLIAIPTTISSEECALLLVEKLETVNAWTEPERLDALVTCIYNHCVNQEQQASNVFFKWLPFFVEPNEDQWKKVLQQISPSNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WDI4</accession>
    <name>A0A6G0WDI4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RxLR effector protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_016654</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000265">
        <property type="protein sequence ID" value="KAF0724723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WDI4"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026287430" description="RxLR effector protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0724723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="143" mass="15765" checksum="5525AABCA7344AF8" modified="2020-08-12" version="1">MRVLTSLALATCAVVAFKQPRKDSPVVSAHQQASAVNDLRTLKQEVPTATHSSRARRLAATGLLTCCFKGQSRTPAIPSGRDSRSASQRRYDTQYEVPIEPQAQQRQGRTQSRPAPQRQESTSGRSSSSSSPVQQYWARLDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WDW5</accession>
    <name>A0A6G0WDW5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Reverse transcriptase/retrotransposon-derived protein RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_016051</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000241">
        <property type="protein sequence ID" value="KAF0725488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WDW5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006329"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF37">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase/retrotransposon-derived protein RNase H-like" evidence="2">
        <location>
            <begin position="238"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0725488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="344" mass="38382" checksum="C6A1A85D0DB47B5E" modified="2020-08-12" version="1">MRSPMSTLDGMLANFHAMQWFLSLDNASGFGVVRATKRAHKVSAFICSLGHFEWTRMAQGLKNAPMIYQRMITNALFGFVVMPPGVADDDADGEPVDMFTLGFKCDLSQLPPPANRTSFADDISDGADSWEGIVELTDRILARLTYFGVSISALKSKFGKIATDFLGHVVSPRGLEARPRSLDAVLAAPFPRCLRDMQSFLGSLNFYSPFIENYSILASCLYEISDEELRLGLVSPAAVRAFADLKAAYSSTPLLRHADPEREFHVLLYTTTWAISATVCQDYDGVLHPVRFCGRTLKGGEPRYEEWAKEVLALLRAVKVCYYELRNMQLVVYSRHCRNDFISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WEG7</accession>
    <name>A0A6G0WEG7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein phosphatase 1 regulatory subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_016470</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SDS22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000253">
        <property type="protein sequence ID" value="KAF0725073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WEG7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011728"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000312">
        <property type="entry name" value="Protein phosphatases pp1 regulatory subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050576">
        <property type="entry name" value="Cilia_flagella_integrity"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973:SF23">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0725073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="38707" checksum="D075EEA70BA58521" modified="2020-08-12" version="1">MEQANQSDAPSIPPPQVVVVREENHAKYDHEEGEHKHDEDESKELQLSDCIELVPGMEEIYHVGTAGLKARVLNGMDDMIQLKEVRVRSNLLYKMTGIENLVNLQHLELYDNQIKKMTSLENLVNLRVLDLSFNEIRSIPDLSHLTQLEELYVANNKLTHITGIKNLSNLKKLDLGANRIRVIEGLDHLTSLEQLWLGKNKITQIQGLSALTSLKVISVQSNRLISIEGFEANKNLEEVYLSHNGIEALANVAHLTKLIILDLGANRISHIPDMSPLSVLEDLWLGDNNVSSFDDLQHLTSNTTLETLYLERNPIASDFEYRKKIHSTLPFVKQIDATPVHSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WGP2</accession>
    <name>A0A6G0WGP2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_015416</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000219">
        <property type="protein sequence ID" value="KAF0726301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004961"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039226">
        <property type="entry name" value="Ski3/TTC37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15704">
        <property type="entry name" value="SUPERKILLER 3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15704:SF7">
        <property type="entry name" value="SUPERKILLER COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="36"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="617"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="865"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="968"/>
            <end position="1001"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0726301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1418" mass="157555" checksum="63EC8A1B2541E8CF" modified="2020-08-12" version="1">MLKHYLTDAKNKLKDEAYEAALEASTKALELDGMNFNALMLKGKSLYHLQNAKLAEETYRRAVDLQPDTPLVWKGLLELFELTQEHAKSIEPLEKLRAILIKNDKWDRCQKVTSDLAQAATLAGQIPKALETWYPLVLSDPRSPALFLGEHPNEETPSEVEIWIFVLRIAQAHRVVGPFKSLDLILDNIVRLVPSLSWSPEDNTSLHSDVVAAIDIAVDNAWRTLKTAPGNEKSQARRVLDELCARLVAECPRAKRAAEVRLIRHEDMDGELSAEDFNLSAPMVKELAPKSSLVAILTGLEQYKAGRPLEALANLSQGIIAVPEHIEARVVLARLSLEEATFDPVRCLDMIHSSQDAAQTRYDTLGTSPNCYSDTEMNLLQARALIAQSKWHDAIMVYEGVVEHEPFLAEAVIGLAEAHLHLGEVDAASLNLQFLPPQPSSAAYFAAKGWLSYCQGDLKTAQTTLEAGLNCADVAWTLKYRLARVYWDLGGDHKTNKVFCVAMLLGAAKLNPREAGIFSMLGSWYRTIASDNVRAEKCFLKALSLDPSCEVAGLTLTEMYTAHGEDARVVQLWSDNAASQVHAAWALERLAQYQLSHDDEAAIGNMHKLLRNAPGNASYWAALGHVYQVFGRIVAAQKSYMKALNLAPNTPNVLCELARIELSLGLLDEALGHLTAIESPNAAVNKLHAETLFTQAKALCAQGLYGRSLAQLHQASHVLTTCVATEHHPCLYKLLGDIHMFAFYLPPTEDWLAFLSQGSDAYAKVLTDQPDDPVALFDAGISQWILAQAKGFLHHFPVTKWSLDHNPIYPEAMKCHVDLARSHLTKSLSINPNDAKVWNAFGAVSGSVALKQFAFVRAIELENLDAAWANLGMLYLHSGLFAMAQKAFLSLQGVNPNHPAMWLGYGLLGCRKNTFADAHAAYTCAIELRLDLDILHGFAYTALISRTGSLDQALFALKKFAERDGYHAAATNSLGVALMRTGLYGQAIDAFEKALDRVQDTVTRDGILLNLAQAQVHQQQFGGAQANLKKRSTPHNLLQAQIHLGRGEHENALALIQSDEFVDNVNVLLAQQVIMYQLGQRESCRRNLEALLSRFPSEEVAKTLLALYGLDWWQSKEQTILQSLCAPLVDLYISRHDHLGVKRFCDSWTSEFPQDPEGYLARARGKLAFGDLEVDLSKVPSARLPFEAQLHRMQIESAVQLFTSWNSSDTACRKWLHLNPADPLAPLVVAIGMLKRFVKNPSDLSIVTRAKQWLARHPPQSDSPYSTWLWHILSSCIHAQVGETTEAKTHAQTALNTIDLFGLDDSATILLYQARTRVYTDPAEAINLYLAHLRASETTTRHAWVELAVLMEAQGYVKTAWRVWRQIESDEWKTLVHIKRSFLQRENPKVATKCLQALENSTSDTFISAFRSEFNLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WGU6</accession>
    <name>A0A6G0WGU6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nuclear factor related to kappa-B-binding protein second winged helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_015384</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000218">
        <property type="protein sequence ID" value="KAF0726362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WGU6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002505"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024867">
        <property type="entry name" value="NFRKB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057748">
        <property type="entry name" value="NFRKB_WH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13052">
        <property type="entry name" value="NFRKB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13052:SF3">
        <property type="entry name" value="NUCLEAR FACTOR RELATED TO KAPPA-B-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25793">
        <property type="entry name" value="WHD_2nd_NFRKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear factor related to kappa-B-binding protein second winged helix" evidence="2">
        <location>
            <begin position="367"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="335"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0726362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="504" mass="56587" checksum="C346A70FC2B7E2DD" modified="2020-08-12" version="1">MGFRGDATDPDVDLTQPFRSRVPKLVSIGSAPPSIAPLNAATADDRAINVLSCLPVDAWDGLTIEEKQSLVEELPPLEGWWGLSADDAAAENLRQLFRGLNFHFGNPLTHFRFPSAERDAKRAADKAAFDRQKRTYIKQLMESIVQHRAQYLKQVLPADELALNPEIDIPAVPTVKEAVDDIEHSFFLAIQAALQSGASTLSAIWSHVQSNAPLAIPSTTEIPKDMEREDYLHSALLFLSRPTSSSETSLTEWDVPFVVHNVETNAFTWRNLDAEEPSETTTRLLFLERLFRMPFNEEPSMGPLESTLQMARKRLRELDDAGADKKSKTMHDSTAPQRPQQAQSSSLPAFTLKAAHRPLHRDYFLTREPFQQQELQRYQHPHQPFVYFDAESGFQTVVGPCFPPIIVAPLDQPTILLPEVAPQVTVLNVVRDAVARLPKTCGTRADVLTLLRMSMFVNPNASLDDLDMTVARSLDTLAAMAHPCVFFHFNNEYGAWLWHYINRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WGZ0</accession>
    <name>A0A6G0WGZ0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_015313</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000216">
        <property type="protein sequence ID" value="KAF0726425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WGZ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014531"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052394">
        <property type="entry name" value="LRR-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="611"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="647"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1193"/>
            <end position="1223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0726425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1223" mass="135729" checksum="72A978081031A57F" modified="2020-08-12" version="1">MTVTTAAVVERDLYIRVTPRQCKKCRALSETSSAAKAAADSCSKCKRRRRQRQRSIWETASLNRSWEIPDAVKMQLPLVARDKAPESTPCETFLQWSNLQLPPPPSATTSVRSLHPAAASATASDGKKQVKRRGFERSRAFLIDAAAVDTNMLLETQRNKYFGAAGVASSRAIYAKLASQRYLQSDGTAGLVDKFKSMLASQNEPSPDAIGAFNSNEAFTARHKFLSLCLDHELPPCLRLIIRHKVSAEINVSHMSMGDALAQVFCQCLVDLPMVLALNMRNNRLTDAGIQAVVDVVVRKADLCSLDISENKVDGAASVALAAFLSTPSCGLTTLALSQCDIDDNEVLGFAKALCANKTLHNLDLSRNLIGSNEALNVVQPDLTTGGEALAEMLTANNHLTSLNLSWNFLRLNSAVELGRALALNNSLKTLNLSYNAFGNDGAQAIGCALQQNMCLETLDLSQNNIPSRAAFVIAQSLHANDSLATLLMDGNPLGRVGGQTLLQAISTAGHRNLHISLAGCNFEIDDHGSFDPLDATGTYDLDMSLPYERAIALELLRLANTQNGCKFLSFVHVMEKAAPRPIPCEKRRASHARAQLLSKRTTHDVLRGRMASDRLEALFKTLDADGSGTITAEELRQGMRTQGLHLSLQEAKHMVARYDLDGSGTIELAEFVDLMSQFYFDDKPLMEWIDTSTGLPLEIPQDGRLQLNFLDLHIPADADETVSKAGIQLLLENIATDPNQVNLIYMAKHNMHLRQTEAQLLLDALVKKIDVVDALVMLLPQVVDANHACPLIELNTDNYQRLRLQALLREMYGPIVGLATGHYALDLGDAHDRATFKKMIELNNKLMTSRREKNLKDTSQHENHSCFRNERLNHHAFVITPAFYDDLPKYGALEFDFVQLSRPIAGILPMSDNRFKQLIARLYLDDAALSLSRSDLATPATPSAAGGAAARQLNVHVYNYLLELQHGQVLVGDLHNRDIAASVPNMQDHSDHLSARRLLMELQALFCTRWLTTRQAILILSRWPPSFGSTRVDAALMLFDRILDLYNFTQIFAALDDEQCAQVIYRLGWLNLWSPLNPELYYELDLTIYEQREVTKVLVELALDEPGENWQNAIFGWDRDSPMPGWVLNMSWLTPGNFPVKGYLRLEYYSGADKGCSPVWPTRRASAQNVLAELPHQFEDFLAHREKIRRAFSRRQAQRESKSAAKTPPQEQTKPLSPPTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WHA4</accession>
    <name>A0A6G0WHA4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospholipase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_015173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000213">
        <property type="protein sequence ID" value="KAF0726547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WHA4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020924"/>
    <dbReference type="OrthoDB" id="3935740at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonate secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.90.10">
        <property type="entry name" value="Phospholipase A2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010711">
        <property type="entry name" value="PLA2G12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12824">
        <property type="entry name" value="GROUP XII SECRETORY PHOSPHOLIPASE A2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12824:SF8">
        <property type="entry name" value="GXIVSPLA2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06951">
        <property type="entry name" value="PLA2G12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="Phospholipase A2, PLA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026063075" description="Phospholipase A2 domain-containing protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0726547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="27334" checksum="89FEAF4AA03455C2" modified="2020-08-12" version="1">MLPLGWKSYVSISLLLLAKVPSTSAMFGELEICEPKAEICKGSKNVVLAPKRSFRNWANGCGTDSLGFQVVANDELDFTTCCNWHDACYGICGISKQLCERKFEKCMKDHCKTLHGENTEAAKSCESTADLYAMGPKYMGCKAFTAGQKEACDCVDASKADGKVRDRLKYVLKQYNADESADSLLDKYKGKEAVMFLRLLTKYPDALVVKKSKRESMFDAFKESLKKAPKEPKDNNDDVDEHIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WHE9</accession>
    <name>A0A6G0WHE9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Coatomer subunit zeta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ae201684_015203</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
            <orientation evidence="1 12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasmic vesicle</location>
            <location evidence="12">COPI-coated vesicle membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000213">
        <property type="protein sequence ID" value="KAF0726579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WHE9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020951"/>
    <dbReference type="OrthoDB" id="10249988at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14829">
        <property type="entry name" value="Zeta-COP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000013">
        <property type="entry name" value="Coatomer subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039652">
        <property type="entry name" value="Coatomer_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043:SF0">
        <property type="entry name" value="COATOMER SUBUNIT ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043">
        <property type="entry name" value="ZETA-COAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 12" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="13">
        <location>
            <begin position="8"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF0726579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="180" mass="20253" checksum="CA2C97C00EDD1940" modified="2020-08-12" version="1">MSGTNPSVKAIFVLDAEGNRLCAKYYDRASYPSLKEQNALEKKIWGKTKTMNARQEAEIILLDNIVSVFRSQNENSMYVVGSSHENELILLNVLDGAFDAVSHMLKGHMDRHSILDNLELVLLTFDEVLDGGVIFETDTQSVTNRVLMRGIDNEVPLTELTLGQAFLTVREQWSRSFRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WHX3</accession>
    <name>A0A6G0WHX3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_015051</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000207">
        <property type="protein sequence ID" value="KAF0726795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WHX3"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0726795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="185" mass="21008" checksum="4828E77C177C3984" modified="2020-08-12" version="1">MGVEKSLEEVTWLNENQSFQSRPSDGLALIFSIDGCQAYSAARRTRRTITALSPARQTRAQAVAMLGVVLHDVESQCFSKMSGGEGLIAFKKDKVHWDRVRFRLHSGWHRSRESRSSNRSRSWGSVPREARRCWPCFTTCQKTRAADAGMYPRRVERVWVNLGLKADNHTISRPSGDIDIRPTCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJC6</accession>
    <name>A0A6G0WJC6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_014577</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000198">
        <property type="protein sequence ID" value="KAF0727316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJC6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003987"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051568">
        <property type="entry name" value="LZTR1/Attractin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376">
        <property type="entry name" value="LEUCINE-ZIPPER-LIKE TRANSCRIPTIONAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376:SF1">
        <property type="entry name" value="LEUCINE-ZIPPER-LIKE TRANSCRIPTIONAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="410"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0727316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="565" mass="63057" checksum="6D8C6D83741D23DC" modified="2020-08-12" version="1">MSQTPRNTAGLHHIGHYSSPLTAADYSLETHNPSLNDSAMNVATYPSPAPPAPISAPSALSPGVPLYGNETRAKATNAMTPSSARSWITVPCQNPSAAPCHRSLHVCAVHKESMYVFGGYDGSNRVNDFFEYNFKRKVWSQVVAIGIPPTPRDRHVAVVYRDSFYVFAGFDGSSRVNDFIEFNFLAQKWAPVAVASGMPPSPRHSHAAVVYDKSMFVFGGYDGSYRNDFYEFNFENSVWSQVSATGRFPRPRYRASLVTHKTSCILFGGHDGSRHLNDVHVFNFVLRSWSMLLVEGPAPIPRDSHVAVIHGSSMYIFGGSTGSAMNDFHELNLETSVWQPMAFNGPPPGQRFCHVGCVYDDSFAVFGGYDGSSRLNDFKEFRFGEEVELDIPSSCLLSDLRELVNSNVMSDITFIVEGLPIYAHKILCMRCSYFKAMLTSEMLESRAREVVISDVRRSIFLAFLEYLYTDHVNVDVETAMELFVAADRYGVDRLKKICESKMLSSLCIENAASILHAADLHCATILRERCIAFMLNNFDAVTKTNAFEEMGRINVDLVFELLKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJE7</accession>
    <name>A0A6G0WJE7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein ENHANCED DISEASE RESISTANCE 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_014610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000198">
        <property type="protein sequence ID" value="KAF0727351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJE7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002778"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045096">
        <property type="entry name" value="EDR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009769">
        <property type="entry name" value="EDR2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12136">
        <property type="entry name" value="ENHANCED DISEASE RESISTANCE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12136:SF41">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY (PH) AND LIPID-BINDING START DOMAINS-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07059">
        <property type="entry name" value="EDR2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein ENHANCED DISEASE RESISTANCE 2 C-terminal" evidence="1">
        <location>
            <begin position="95"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0727351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="325" mass="36674" checksum="72B434D61230B7AD" modified="2020-08-12" version="1">MTAFIERLIQTSIVFLEGLLLPLEVLLLLLFKSKPLACTVEQTAVHHYNNVPVQPQPIVHAKSDSCLAPSRPLRRTMTWEEKYAQVFQSKTRKMWSEPRGDEILVRGPKYMTDRTKIPAGKSVGTLVHVDVWNETKTRRGRQDHIAQADSTRAKSLVQFFAENKPDDILLVLNFQVPGTPFVHVVCYWLLPGGELTSLNVWTQFIAAIDSQDVTWCNNRFKLIPVIVDGPWLVKATVPQKPALIGNKLTQRYFRGANYVEIDMDINSSTIAANIVGLCRGYSKQLVVDLHLTLQGEKNDDELPERILGSVQLSHLDFACSQAIMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJG4</accession>
    <name>A0A6G0WJG4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_014636</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000198">
        <property type="protein sequence ID" value="KAF0727378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJG4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020663"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021627">
        <property type="entry name" value="Mediator_Med27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13130">
        <property type="entry name" value="34 KDA TRANSCRIPTIONAL CO-ACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13130:SF4">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11571">
        <property type="entry name" value="Med27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="231"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="239"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0727378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="411" mass="46390" checksum="40FA2110BA260B73" modified="2020-08-12" version="1">MSDPIGIADIMAGRVGALRAAAESLILELGNMGNRTADDPEANATAIAASLKAKVDRVQNNLTILRKLSTEFEDNTKDVEKVTQAQRNLMFEYYWKLQVREMAGKGANVWLSQMSQWFPRTEYLSSHASSLFPPSAHPASDKVKAPMKVIDRFTPKPSKRARSLVFDEQGDVQPADLGQMMEYIMKRTKATKFWKQTETTRGGRKVITSIMCQLNNEIVVHMSFCPHIPEDGPHGDNGVSASPMTPSTPNSPAFGMNRGIRAKRQASLKAKKIIKKTKRDDLLAKVKMAAEEASKIEQEELRKLIIDAKESGKDQEIARAAGHQVTKFIQRVSVFPLNEEAPLGAWSESKHKLFEQITMHARQALHYLRVHYPETCFYHFFTWMSYFEKIYQTPCHACKKILYVSSLARNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJU2</accession>
    <name>A0A6G0WJU2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_014357</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000193">
        <property type="protein sequence ID" value="KAF0727527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJU2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002536"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0727527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="593" mass="67066" checksum="23F02D7D6AD1BF94" modified="2020-08-12" version="1">MDMSQDLERLSISPDSSVKVKNKCSFFMLVESPTGRGMNCIVCCCFKASSIFSMVSQTAPGTSRLQDNSLETNELEQVYDLFRFYDSSLHGDKLPSINLPRFIEILKDGHILSSTFTAQRKKCLPRLCLANCGRTWTLFPTISPGAALRKLVRRHLFSLMNEVVPVSEQLAPRKSVAGAINDNYWHPLEAQCEVRLQRRRVSQVAYDKVVRHIFPPMEQPAPLDAAITPEIREFFTEEHLALIVDRFHTFDHTDSGRIGKDECFVFFHGLADALRLESPRHLAMQVDGEDISLSQIFRVLMASTEAASPQFQSQTHVAFPDRPTTDDVVEKKDALLALSHDCPPDDWEPDDAMSTTSPVKISTAVDGGSANNTKHITITTKMTKKSKRQNTRDDAVLPRVLMIDSRQSVKKYWEGTVCLTGLAETTGLFQKGEKRVLSENMTKMNSATASISLMKLRVKYKLAEGYVVAEGKKYVADVVASDAPNTKSKQIKKLPPKKLSLDRCSTIVRSMPQLPLYSPNHHQPLYKKPEYQLPTNLKALVVDHKNLSWVHETFPRLHVDDNRRWRTEHIQAEEYMKSMAANELLPQLHQANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WMP7</accession>
    <name>A0A6G0WMP7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_013557</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000175">
        <property type="protein sequence ID" value="KAF0728596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WMP7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010924"/>
    <dbReference type="OrthoDB" id="285674at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050486">
        <property type="entry name" value="Mannose-1P_guanyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22572">
        <property type="entry name" value="SUGAR-1-PHOSPHATE GUANYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="3">
        <location>
            <begin position="268"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0728596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="370" mass="41290" checksum="9065862D2D52F7EC" modified="2020-08-12" version="1">MDQPTPLFPIAGRPMLYHHVEACSKVPNLKEILLIGAYDSGLFASFMDIVTRDIQVPIRYLQERQHLGTGGGLRTFRNDIEDGQPELFYVLHYDICCSFPLLDMLHSHIRAQAFVTVLGKRVYPDEAKTYGCMVADPDTSEVIHWAEKPSTFVSDLINCGVYLLNIDMLQDIVEMGDALVDQREKAQLRSAQYPQLFHHHMDKLRLEQDFLFPMAGTQQLFVYETGDFWCQIKTPGMAVMCSELYMQRYRYVDPTLLASTGGKFSPKIEGNVVVHPSAVVDPTAKLGPNVCIGAGVTIGRGVRVAHSIVLAGVTVRDHACILFSILGWNSIVGEWARVEGEPPNDSTKGQRDVTIFGVSVYCAPELILPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WMW6</accession>
    <name>A0A6G0WMW6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_013610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000175">
        <property type="protein sequence ID" value="KAF0728652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WMW6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002193"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="476"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0728652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="673" mass="75561" checksum="C728E515C83DA477" modified="2020-08-12" version="1">MMARIPWARRAELQVKATNWLIQLVGALGASLVIVDMCYNNWELINYMGNAQYLLTPLYNHGSLHDVALNYVFPTEASPSKLSEGGIYMLNSTISTAYNRDRDYYFLTAGSYLIEDAQNDICGTLAKSYPNVNASMTTINLGVTTNSLFYVRGSTLMNFFGLTSTTPAPAKANGTTLAALGYAPARQDCDLRLTTTVAVPPSGSVVSANVTMYRFFAKSYCSGCNSVVELGRDTCAIVYSYNATTRVLKVQSSQAFIGDYHFLGVMLERSGPSVGSLYIRGLCVFLAALGYQASKKTIRWTDATALASWYRRILHTLAPPLYRYSSKALSFSMYCLNSDLFVFGYTTAMLLDEKQSMIFNRHLTKWNTSGNAWIQIQLFAIQFRWLWLNCALVKVAKWLFNFVSLTRYTGKNLLVGWCNFSSVLYVYVGAIFLLQRTNFIQYGNNDSVTLTSTTDNLNTIRLDLFESQYVRAIPDLILVMIANLIMVLALDHILHFRWWRRMTNNSLGRQVMYNSTSIVADMQFEFFDGENYKGQAMAVHARALCTVQWFLLCHTWCFGLQEDPKRVRAMVTNGIHRIGGGDNRASAWAASDSVRQAAVAYDPMTFRGKKASVQPEIDEEGDLNLSSSSSTLDLYMLAQDPEGHVQLYDARKREIQAMSLEVKILNDAKYIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WND5</accession>
    <name>A0A6G0WND5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TOG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_013402</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000172">
        <property type="protein sequence ID" value="KAF0728832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WND5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000478"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024395">
        <property type="entry name" value="CLASP_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567">
        <property type="entry name" value="CLASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12348">
        <property type="entry name" value="CLASP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TOG" evidence="2">
        <location>
            <begin position="52"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0728832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="331" mass="36808" checksum="77B86F72C71B5270" modified="2020-08-12" version="1">MKRRNPFSGNDALHKKVHMSIDKDENGEPEVSATKDPGAPDNEDDLTKVVVLLQDQLQEPTEKYAWDPSIANASWSDQYAAIQLFRETIKFHADYIQNDFPDLEPCLSNLVVPCAVHLRSAHARQSIYCIGELVQCLGDAMSSHLSIFLPILVTRAVNEKKFIREAAHDALSHTIASCNPITVLDILMTFSTDKNPQIVAAAGESIERVISQNRVEESNQSSPWQDHLDGWIDPLAKFLVCRVVSCKSATKRSFHRLRDLVGADTLTAIASRHLAGSNLVDVLALISSTRPNSSSGMKPASRPSVSSLRARMLRQQQQQQEQQKQKTTETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WPF0</accession>
    <name>A0A6G0WPF0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_013191</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000167">
        <property type="protein sequence ID" value="KAF0729214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WPF0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003611"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF8">
        <property type="entry name" value="7ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0729214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="205" mass="21833" checksum="49EF3EC1E67E1E6A" modified="2020-08-12" version="1">MAPIELSDIGPGKCIPINEDLSTIEGCQRLATALEQRESKLHVLINNSGVIWGGGFKSHGKKGWTNVMDLNLTAPFFVTKFLLPLLGTDARVINVGSIAGITTPNAGTIAYDTSKAALHHMTKVLAAELAPRKITVNCIAPGLVPTTMSHQLVYVTGKPFDETANEQIPLKRSGVPTDMAGAALFLLPLPLHGSLAPSWRCMAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WQS8</accession>
    <name>A0A6G0WQS8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_012693</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000161">
        <property type="protein sequence ID" value="KAF0729805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WQS8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006358"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="3">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0729805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="450" mass="50881" checksum="AAEC2CE479FC64B2" modified="2020-08-12" version="1">MSYPEPFLRWIKEYGGAVYNRELFAPVVFLSDPKAIQHVLAIDGSNYPRHPSMRAYTKENLFGSTLLNSEGAGHDNQRKMFNPHFSLSHIKAFIPIFEQLTRERLLPVLNKAAKSNELLEMNCAFQKLTLAIIGAVAFSFDFDANPAVHEAFVQMFEPPSLTTFLGLIYIPGYEYFPLPELRRRRAAKRALIEAITGVIDTKLAVKNAPKDLLDMFLPNTTPAQAIAHTMQFIVAGHETSSSTLGWLVVEVFRRRKVLAAVRSEAIRVQKKLGSVASWEATQELKYTTAVVQETLRLNTVVYSIARRIANEEDRVPMTDGSTIFIPKGTGIDVFISAMHRNPRYWSQPDDFLPERFIENTPEWMADEQLRRGSNHTFFYLPFSFGSKNCIGQRFAMAEMVVIFATIVTQFDFEIDPKCNLRPKFNGLTILPAELLVKVKHVEGIQSGIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WRM5</accession>
    <name>A0A6G0WRM5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nucleoside diphosphate kinase</fullName>
            <ecNumber evidence="9">2.7.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_012380</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="9"/>
    <dbReference type="EMBL" id="VJMJ01000156">
        <property type="protein sequence ID" value="KAF0730084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WRM5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003327"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04413">
        <property type="entry name" value="NDPk_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.141:FF:000002">
        <property type="entry name" value="Nucleoside diphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001908">
        <property type="entry name" value="PRK00668.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11349">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="10">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="7">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0730084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="149" mass="16697" checksum="7D69CD86E84955A0" modified="2020-08-12" version="1">MERTYIMIKPDGVQRNLVGEIIKRFEQKGFQLVALKLVRPGKAHLEQHYADLAGKPFFNGLIEYMNSGPVVAMVWQGANVVKEGRKMLGATKPSESAPGTIRGDYAVEVGRNICHGSDSVESANKEIALWFGEEVIEWDATRNTWVYEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WSG0</accession>
    <name>A0A6G0WSG0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cyclin-dependent kinase 2 homolog</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cell division control protein 2 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">cdc2-related kinase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Ae201684_012349</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">May form a complex composed of at least the catalytic subunit CRK2 and a cyclin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="VJMJ01000155">
        <property type="protein sequence ID" value="KAF0730355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WSG0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012520"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000054">
        <property type="entry name" value="Cyclin-dependent kinase 11B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF107">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 11A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="23"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="325"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="329"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF0730355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="360" mass="41243" checksum="EEE62A22BFCF021C" modified="2020-08-12" version="1">MTSAAQPRLKFEAFGTCRDVDEFEKLNRIGEGTYGTVYRARDKKSGEIVALKRVILHNEKQDGFPITAIREIKLLKRLQQENCVQLKDVVVGRKRSGVFLVFEYCEHDLSALMNNNHRPFSQSEAKRVLIELLRAVEYLHSMNIVHRDLKLSNILYDGFGRVKLADFGLARETGFPAPFNMTPKVVTLWYRAPELLLGSESYTSAIDIWACGCIFGELILNKPLMSGSTDLEQLQLIYKLLGRPTERMWPGMSSLPNASKLYFDSSAYVYNNIPKLFETQLSEAGLDLLHCMLTYDPEKRISAADALRHPYFDERPFPKEVGMMPTFPSRHDEMRRPVSSRDDHNFGRAFGSSDKKRKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WVA1</accession>
    <name>A0A6G0WVA1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_011294</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000143">
        <property type="protein sequence ID" value="KAF0731391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WVA1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021383"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0731391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="395" mass="45999" checksum="28FFBFC8AA6F9AE5" modified="2020-08-12" version="1">MNPVLPFKLPSDTLVNIAFYIEKVDILFALLEALRPAYDLGILEHVRQLHHQLHWKKNDLWPRLSLTEAEESSLVHLEPIIKYYSEVAVNDMTQVEWFCPLIDLTTRITWTPRRRRLDPTDLVPWKSFRITRVDPWFEDCNQPLQTLLLLPHLEEIDCNNCNNQTAEAIFKFAATSSNLRSLKVRTGQRSSSPAWITSEMADDIMQWNISRPIEVFRLWKFKWDSQALRDQVVASVLGNPALEEFTLDETLDDIGNYGFCAYYNREDHSLKLTLSDANNNQASAIDQFTPAMAVFAQLLRTKITKFCLVESWIKKSHRIWSILAPLLQECPLETLSLELTTFTVDDVRIVTQKCHSKLRNYSSRQPQLQSKSCQFDPKERLDIRIKNGEFYKILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WWC8</accession>
    <name>A0A6G0WWC8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_011125</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000140">
        <property type="protein sequence ID" value="KAF0731827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WWC8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010548"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF275">
        <property type="entry name" value="LD06095P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="35"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="606"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="619"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0731827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="972" mass="107999" checksum="91B23BF5911B58D3" modified="2020-08-12" version="1">MAPPPTCLPATEMNKIERDLIDWALYITSGLSAIGCLYVIVLFFKSPRASHNVTSMFVVTLAIFELVIAIAKAPATHFVQFDMFNNTYVKTPTQPQLLATMCQVQSFFIYVFMLQAVLWTGCTAFSLLRWVVYRDTEERLLSRFWIYLFSTSAFSLLCGLLAALPVYPYNGGDAASLYGFARTFCWMRDPKLSLQLFIPFVVATLLFTAAVMIKIRSVVSARAKQHAMLGLANDDVLQIQRTLFFIVFAFFCLHSPATLYRFMQEFTQNPRDPVQAGTARTTYWCSIGATNVLSIVGQVFINSQGFVNAILYGRFIDPNDTDRRSMTLADRNAPSVYLEDAVSSVSGSVAPSSDESASIFASTFNMAEGAVPTEEDLALWIPPGHDVYVIGLQECLNLQAMRGAIGAHLRRINGKVYVEYGREIGRKETMLGYHGFIAITIYAATSDVQAGHFQVHLDSTSKVNRGVNLIGLGRASNKGAVGFAFRLYNLTFAVVSCHLASGTSKIKKRHRDGSQILSSLHLQSIDNEFDCHLMAHHTIFMGDLNYRLTMHDASPHAILKIVTAVVNSNLVNNSMKRGQVFSHEEFITPVVGQSSRLGYREEQDDGYTLTTSPAAGMPRRSEPSLEDFPNERQSAESTMSTLTAPSLIDASWKTLMEHDELKCSMEHGEIFHEFEEARIAFAPTFRRVVGKMLHLQSQWTLHQVAQVYTTVVNKGETRVPSYTDRILFHSLPGLRDRLACVQYTSAECILTSDHKPVSCIFHALVDKRSPSQTPVASPQNTEQKEPSKLRTYNVSLSSLELQWGPPLEAFSSDGEAVDSMHPRLTKDAALASLEPPSTDTLRLRSVFPLPCEDDFAEERKLAEVADHFHASGTKHQQQQRRLQPTWKLQNWAQLANGGTLRLSALLVPKRHFHVALHFITPLGTTVGQGIISLTEASTRPGRKFDFVASLTTGGRRVGEITGKVSLTNVPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WX22</accession>
    <name>A0A6G0WX22_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_010703</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000137">
        <property type="protein sequence ID" value="KAF0732050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WX22"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015189"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20532">
        <property type="entry name" value="CYCLIN_CCNL_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20533">
        <property type="entry name" value="CYCLIN_CCNL_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036580">
        <property type="entry name" value="Cyclin_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0195">Cyclin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="3">
        <location>
            <begin position="23"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="3">
        <location>
            <begin position="141"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0732050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="368" mass="41908" checksum="42CE67B8BCBA205D" modified="2020-08-12" version="1">MTPSQHEGMSAEDEKRHRFFACELIQESGILLQLPQVVLATAQSLLHRFYTNQSFFDFDAFRAAMGCIFLAAKAEEQPRRVKDVVQVFFRMRNRRMGLGLSFLTPSDVRFTHWSDWLVMVERQILIEVGFSIDAITEHPHKFLLYYVKMLDCSNECAQKAWNYVNDSFRLDLCMRYDAHVIACAAISLAARVLQHPLPLRWEKLLEVDEADVIVVAQEMLDLYSFVPIRWLEPLTEVNPFVVTKDDELLRLPSANEEAPTAQEEAPSAQEAIHSPKAIEAEPANDQAKSPSKSARRNIENAATAATVLKSEVEAVPDQVVKEVDPEIERTIDATVEVYRENECAIEVETEVVQEAVIEVDDDIETKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WY63</accession>
    <name>A0A6G0WY63_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_010410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000131">
        <property type="protein sequence ID" value="KAF0732515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WY63"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021581"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF214">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="83"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0732515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="358" mass="39966" checksum="1847E8BFA87F91A6" modified="2020-08-12" version="1">MGCIPSTARLARGRSKDDLIVSGYSPRAILESPVEDATFTKRFSLFTLLRPIQSTFLDVDEPSLPEALKPLAGQRELDVEDVMIIRSIFTSTDTGEDFLLGHYNHHPVLVKRLHENSDKDLTKEIITLAKLHHPNIVSFIGFYAIDGVGLHCVTEFVEGHSLRETLENTQVKLTWESDKLAIALNIARAIAYLHAFKPPIIHRDIQAKSVLLAMNGTAKLTNFGSARERTFDVMMSHRGVGTLEWTAPEVLYGDDYNESIDVYSFGVVLIELDTRTTPFAGHTQSLHSTELMNQLKTGKLRPQVSASCPKEIARIARACLQHDPANRPKSSQVVAHLENALATQQENMYMDAAIFDFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WY91</accession>
    <name>A0A6G0WY91_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Crinkler effector protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_010463</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Host cell</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000132">
        <property type="protein sequence ID" value="KAF0732474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WY91"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013787"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043657">
        <property type="term" value="C:host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045379">
        <property type="entry name" value="Crinkler_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20147">
        <property type="entry name" value="Crinkler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Crinkler effector protein N-terminal" evidence="4">
        <location>
            <begin position="3"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0732474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="419" mass="47693" checksum="67B3AA58FED8AAD8" modified="2020-08-12" version="1">MVFVAVVGVGICSVDIELNARVVDLKKKIKEENPNEIRCEAELLKLYLAREGDKWLNCEDHDEMALEKGEIPDRIKNLMRDEQLMFGARTLNNDAYFGKTFEQVEGDIHVLVELPEGAKRDVTAATTPLTAEQVRMAMNKVLDERDRKRSEYAISTCPLSKEMVFKRQLGLEYSSVVLREVVDDSICGYQWLALPEKHPDQRKAVMKYVEEHLGDALISEQKNFLKDVAGMHDLLDCDDRRSLPFKVKGTADLMLVDEVANQMNDEGSSKLRGTMAVLLELAVADLKSESHCAPVGLLTNLNDYWYFLWFTPERKIARTVLKCPANAFQTMKEVLKETSGPTRDGHFPMRVAFMESPRPLKRQKLRPSPTGCDNAAAAEMLERYELMADQLDPKFLQQQRIAYAFELVKQMPIHSAMDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WYS6</accession>
    <name>A0A6G0WYS6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_010097</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sel-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000128">
        <property type="protein sequence ID" value="KAF0732765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WYS6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003551"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050767">
        <property type="entry name" value="Sel1_AlgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102">
        <property type="entry name" value="SEL-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102:SF147">
        <property type="entry name" value="SEL1L ADAPTOR SUBUNIT OF ERAD E3 UBIQUITIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026076618" evidence="2">
        <location>
            <begin position="27"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0732765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="707" mass="77593" checksum="AB63BD9D0307AA34" modified="2020-08-12" version="1">MRSRGLKRCLMLSVTCFILGMTMVMAVDALKRSSKTAQVWVYDDAQNPWDGKLVEVQNADDILRRIHDFLDTATSMVRGGAVDSTVLANLETELYEHFFDLADLAQSSTASKITNQIFELNSSLQDLLDLLVAERKATSQTSSTDSSEIPLSDAFLDVYDELLENGHSTSTFTKWVDMAASENARGAAYETVGMYSLFQPNAVAFPLDLDAALAYLKKAGTTQAKVLDAILRLALYRDESHDNVLRASTSTNFLARVALAHRIYSNATASVLSDPCEEALVYYYTSAEESVADMISVGGEKDIYEPMVRLSDVWSGKVSASSDDLLVVPTHGVDALDYVRALAFGGNPEALHRLGEMHFFGDAQAGLPPNHQEAVRHFEQAAAGGVVHSLANLGLMYANGIGVQADPQRAIQYFQEAADRGSAFAVNGLGFMFWTGLGVEKNATAAVEHFEKAVAMGFADAHQYLGAAYLNGEGVARNESLAFYHFSVAVNQSNSLQAWFNLGIMYYRGLGTPRSCPQSLEAFREVTWRSAAFDDILLSQRLGFESYTRGDYQRALVHSLVWSALGLPQAGCNAGFLLEQGQADAFTTKIAPLALAKDLYSTHISDAEALRKLGHCHRDGWPQACPRNETAALEYYERAGQLADSESLYSAGWLYSAQGDWGRAHDAWTACQALNYPDNIPCMFPALLLDVWAWYRALLVHWSVFIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WZ63</accession>
    <name>A0A6G0WZ63_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_010124</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="8"/>
    <dbReference type="EMBL" id="VJMJ01000128">
        <property type="protein sequence ID" value="KAF0732794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WZ63"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015242"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013235">
        <property type="entry name" value="PPP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051134">
        <property type="entry name" value="PPP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08321">
        <property type="entry name" value="PPP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="471"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="568"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="609"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="539"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="679"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="684"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0732794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="708" mass="80443" checksum="663248095A0D5738" modified="2020-08-12" version="1">MGNKSSKQTKAPRTPGKKEETKELPASNQDSQKEEVEPTSPTPSSSAETPTSIGDDDRFSTSQWKLFNDLENREEAEMVELSSFLRALHDHMPSQEAEFGELGPPPPSGSLRMQQNISWHAAASIDITDMYQGIILNDPLTKEDAHNLVESFKRGQKLHRNFAMHILSAALEMFQNKPNVTQITIAPSPHITIVGDLHGQLDDLLLIFRENGMPSPQNPYIFNGDIVDRGTRSIECALIIFTFAVVYPDSVHVNRGNHEDKSITEVFGFMKECLQKYDAEVFHMFTVIFKWLPLATILDKRILILHGGIPREASTKLDEINALPRQLYDLSMYRTKGETRESRKMFKSMRVIKDILWSDPHTANGWKENARGAGINYGPDHVYKYMVKNRLELIIRSHECVPKGFDWPFGAKGMLVTLFSASNYCGVANNMGCFMRIPVTGKPSFFQYMATTSESDLVATNLEGLFEVIVTHRDELLRQFQAIDPNGTNFITIPQWERVMEDELHMKLNWTSIRPLITSTEADKTINYVNFLNRYQTRGTTTSSDGASEAEDSSGTEQRRDMFNNMYRYRKRLQALFQVFDRDGNGTINLDEFKAGIEILNQHLPPGMKPFTNAEELMRSLDFTHDNEININEFMECFRIHANLTVQAKWRRARTKLRALQALGMLKVVADAPVVTASDVQIDLPDDDDDDDEDANGGFRSEDEDEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X060</accession>
    <name>A0A6G0X060_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_009993</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000126">
        <property type="protein sequence ID" value="KAF0733176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X060"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012825"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827:SF1">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0733176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="259" mass="28976" checksum="7DB135B0C1372828" modified="2020-08-12" version="1">MYHFPICVGLFIDMTTCTFNDCSYEALPGSTKCSFHKNRRQCKAADCRNQVYARGLCVRHGGKKTCEFNGCTLFARGGNFCAMHGGSTVKRFCRIEGCQKQAHAKNLCVRHGGGRLCYFEGCQHHAREGGWCHKHRHCQRSRDSSFTSPIKSETVASPVKPVEILPIPVPEVSKMSSPSELYHQWLQLTREMLFGLHGDPSSIGALSTLLAPLHRLPLPETKSDRFSHKVDWDSLLLDDDVLMSDELAADFNGLFPVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X101</accession>
    <name>A0A6G0X101_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase F1 complex delta/epsilon subunit N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_009694</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000122">
        <property type="protein sequence ID" value="KAF0733448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X101"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012390"/>
    <dbReference type="OrthoDB" id="270171at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="entry name" value="F0F1 ATP synthase delta/epsilon subunit, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="ATP SYNTHASE DELTA/EPSILON CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822:SF7">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT DELTA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="Epsilon subunit of F1F0-ATP synthase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP synthase F1 complex delta/epsilon subunit N-terminal" evidence="11">
        <location>
            <begin position="31"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0733448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="164" mass="17223" checksum="CE29EEBCE79F05C1" modified="2020-08-12" version="1">MLSRVVRRSIHSTAIRAAADQAASGAATKVTLNLNTPHESFYKGAQVDLVQIPGLVGEYGITAGHTPIISQLKPGVIAVHEEREKVVKKFFTAGGFAFTHANSTTDIACVELIKIEDIDAAAAEAGVQKYKAALEQAAEGTPEKVEAQIAYETHVALVAALASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X1X4</accession>
    <name>A0A6G0X1X4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_009376</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000119">
        <property type="protein sequence ID" value="KAF0733809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X1X4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003491"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="477"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="480"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0733809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="497" mass="54287" checksum="5A91109BFBAC9A82" modified="2020-08-12" version="1">MNPERLYPPPPPPVPVPAPPVAVPLLPNTALFRAALPRPLTWQRPADVNNRIPIMQSIQALISQTSTPLLGSHNNSSTLGGLARKLETYLYIESASYAEYANLQSLPRRVQALTTAIVNRNIRKRARSASSDVQLNAVLPPLKVPANPTTIRSHLPPSTSHHSESLATLFSFTGGDVWHALVWEYVGGLDTLHCRGINRNAAHLAPTFVKVLHMSCNAARLLLATGHAALSQCIHLHELEIYSLAAGITFGRRSMFARHCSQRFVVTHDDHEQIVSLLAQQLNRRCWPRLRRLSIVCLFTNDQANGEADVLLSCLKRGVCPALTELSLPGNSFGDYGAIRVAELLQSGVCPQLTLLDLRRNFIGERGLQAVALCLTQGSCRALTELCLGGNMVTDSGLTHFLVAMESCQIPALQFLGLEMNYLTAQGIQELGTAVGKCGCPRLTQISFGENSVDDSDAKTILAQAIFIERVKQKRAATGANPQQNPQQKQRVVRVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X2A4</accession>
    <name>A0A6G0X2A4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ae201684_009167</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000118">
        <property type="protein sequence ID" value="KAF0733992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X2A4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004473"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000123">
        <property type="entry name" value="Potassium channel KAT3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.630">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003938">
        <property type="entry name" value="K_chnl_volt-dep_EAG/ELK/ERG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050818">
        <property type="entry name" value="KCNH_animal-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10217:SF435">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN EAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10217">
        <property type="entry name" value="VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01463">
        <property type="entry name" value="EAGCHANLFMLY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="111"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="346"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="682"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="719"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="843"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="892"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="919"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="14">
        <location>
            <begin position="448"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="14">
        <location>
            <begin position="1023"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF0733992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1238" mass="140970" checksum="80907F2B4722B193" modified="2020-08-12" version="1">MNGIGSTLRAVPRNNAVAPGPPATSTKKAKPAIPGMHRSASKPRAKTLNYEGEYVPRSLNSTRAETLPSPKARTARKIQKDSRLSKSYRRMLAKAHDSKTFIINPKDSNSVLWDIFMGVLIGYSGVTVPLIVCFPGFQTSSDWTWANGIIDVCFGIDIIRNFLVGYHDERDELVVNHKEIAKKYLKTWFLLDIVSTIPIESITTYFGNQSASHSFSSIQLFRILRVARIIKLTRLAKLQAFFAKAETAFGFNAGMVRLVRLVLYVLFISHLLACFFHLLGQPNDPPTREPSENPPVTWLCPPDVRMRCVRWESDSVRYLYSLYWVITTLTGVGFGDVVLVNVFERMYAILAMIIGASVFGFVIGNISTLLESMDKRAAMYQMKMMLVKDYIRNRNLPNELRHKLKRYFEHYLSRASLFDESSILGELSLSLRNEIVHETCKDIFQIPAFSLINPQFVMDMAICIKPLFLLADSVIAKEHTVGREMYFLNSGVVAMYNSSLNGKRVLLEVMSENAYFGEASLLYFALRENTFQSVTNCDMYTLLKEDFDVLVEEYPETEGILIEFYEHREQLYQETLDMTMKRYALYETMKDDDVKMSKFEDYCPHLKVCYNGKLTAIEQLPMEILRNIDFNIAPKVSLFNSSFAKKVIVDGIQNQVLYSKNWRARISVIIDPHNAMKLRWDVWLGILIFYNVISIPIQVAFQGTSSGDDPALGDVVKSYIDIVIDVFFALDILLAFRTGYYDSQGNYIESSFKIAKHYCHVWFWIDIVSTFPFGYVFNNYVGTSTSADGTTTQTSSAVPYQNLKLIRFARLIRLLKLARLLKFNKSFGSVENVINLSPAATRLLMLFLQVCMIAHLSSCAFFFVGATSNDLYDGMSWISDQGLNNATLGEKYVMSLYFAFTTMATVGYGDILPISHLEVAYVIFYMLVGASVFGYIIGSMSSLVDQMQTKSTTAKEKMNRVKDYMKERRLPKPLCNRIRRYFEFYMSQKEIADESAFLDDLSDDLRTQLVLHLNRDVVSKISFFSHQDDACISYLMGILYQECCTPGEYIFYEGEYGRHMYFLVKGTVAVVINAGTSKEIICKVLTEGSFFGELAMLLSSKRCASVRAKTFGILYVLSRNGMERIRTHYPDISNQITREIRSKLQKIKADTLAQPNAGQMAGHIPDEENFTKEMEKPIRESITMIDRALSTLMGYYGDGEKGKRRSIACVIQHLKKFEFAHRDEIGHATDSTKLQPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X2Y7</accession>
    <name>A0A6G0X2Y7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_009109</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000117">
        <property type="protein sequence ID" value="KAF0734248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X2Y7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015165"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015166"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015149">
        <property type="term" value="F:hexose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF8">
        <property type="entry name" value="FACILITATED GLUCOSE TRANSPORTER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="26"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0734248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="500" mass="54600" checksum="6A69630A1F4772B1" modified="2020-08-12" version="1">MSEEGEFTKVEVADKLLKASPILQRSVAVALLGAAQFGWMLSEMGHLPFNNASLCRQADIPEGQCLLYPGHTTAQWTMQSTAWALGGALGALASAFLADTYGRKHTLGVNGLVMILGGLVQMLAPDMETFALGRGVSGIASGVAVNVLNNYLREVAPKQWRMFYMTLFHITMGFTAVVVSALMFAIPKVPTSAWQFKPLFGGPIVIGGLQLATMRFIVESPMWLLHRHRDTEAKQAVSQLYMSGDIDIYFVELAESMRAQTEESEAASSMLGLLVSPRYRVQFVIAVVLGTMQQLAGMSALVVYGPSIFKAIGLADLRLANIFMNYGRTHNMIIAALIGDRFNRRTLLVRLSVVMALAALGFTLCQVYMNDTSKYVVLVMLIFCVTSYTLSVGSLGWLVSTELLPEALAPTSGSFATFGTWMAQLFIGVYFQQISSPTHWGTQAFAIFAVLTLLFAVLAYAYVPETRLTTTDQVTAIFTRDNQDMFDSISTPKTPQTGDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X413</accession>
    <name>A0A6G0X413_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_008717</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000109">
        <property type="protein sequence ID" value="KAF0734640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X413"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005145"/>
    <dbReference type="OrthoDB" id="1658724at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026223350" description="Fatty acid hydroxylase domain-containing protein" evidence="5">
        <location>
            <begin position="30"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="160"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0734640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="337" mass="39198" checksum="B6705BC8E5EBA9A2" modified="2020-08-12" version="1">MSRTASMVAGMAAATAVLVAASAAVNTTANKTSEEFSWEAELERINSLEFLVPYWEYMINNYSEFTINAGFTFVLHQIVYFGTWAPYIVLDFIPYFHKYKIQANKPNTWDDTWKCLKYIFFNQVFVQLPMIISSDQTLKMLGFGMQTPLPSLFTIFWKVLVSAILEDFYNYWAHRFLHWKRIYKYIHKVHHEFAAPFGITAEYAHPAETLILGVGTFLGPFLLTRHLLTLWVWMSVRIIQSIDSHCGYELPWSLTRFLPFWGGAVHHDYHHEKFDVNYASFFTVWDYIFGTDVTFREAQHAKVLAGESHWSDFFYKIGVATYVKDDAKKGNKKAKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X678</accession>
    <name>A0A6G0X678_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_008051</name>
        <name evidence="3" type="ORF">Ae201684_008052</name>
        <name evidence="4" type="ORF">Ae201684_008053</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000096">
        <property type="protein sequence ID" value="KAF0735484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VJMJ01000096">
        <property type="protein sequence ID" value="KAF0735485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VJMJ01000096">
        <property type="protein sequence ID" value="KAF0735486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X678"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008540"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0735484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0735485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0735486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="574" mass="65204" checksum="9DBA3A51FDDB3800" modified="2020-08-12" version="1">MAHPHFFRVNCAHSELFRESYIRCFQNNGLKVIRCFPHCCPHTASRGCGASLSLLVDGINAAEPDTLYAFGRFELAAEQALADGERVDWTVFSNHLRGKKNLDGMWLQGRRHVDKTHAVAFHFNKTRTDGWHYEWKSGSSKLKRDMLHRFHVYVVQRESSDDGRIVLSAYSPPFTLASYRRSVGTQMETSSSSRCTRQPRISQLAQTPRRQGLDKAETLFRLFQLASTLFVDEIPPPQWSNIQVTLSIRCVAWSGLNLQPVAMQILPNERHPDSPNVWTLASESALKVLWSWFDTTTLELFERLLDRTAGNYRATYEAGVEAIYETFVVQTFENNMDALEKLLEAHQVDDSTADKMYYDAFVCLLRESSMNSTSMRTTTDRAPSGCDGVWRLVSTQTTRLDGRPTVLSFFRWLTMLFALELRIRENVLFVQSKLRMFPAPSSMFYLDGQPGTFHTLPNGEVCGLDQRAVVGEYKAWMDFGTVQLWIYRWPKESSSDDSSSLLRVGVSPCALDASVLRISWTLEEATSSSTTAVDLAALPVEDRMNAWDDMEHQVVLQIDTAYSRVADAQVRVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X6L7</accession>
    <name>A0A6G0X6L7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_008041</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000096">
        <property type="protein sequence ID" value="KAF0735473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X6L7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006278"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF37">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13456">
        <property type="entry name" value="RVT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNase H type-1" evidence="9">
        <location>
            <begin position="517"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0735473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="659" mass="73849" checksum="0EC569A273E40614" modified="2020-08-12" version="1">MAKEVVLREGIDLSTEELEQDELSDDEKEKMRVVLRKYRMFFIKSGNGLPPPAKGAVCDIDVGETKPLAERARRIRPELLKNLFDLLRGLLDFGLITFSNSPWASPIVLVLKKGGKDIRRCIDYRSINELQELMRSPMPTLDGMLANFHAMQWFLSLDNASGFWVVRATKRARKVSAFICALGHFEWTRMAQGLKNAPMIYQRMITNALFGFVDMPPGVADEDADGEPVDMFALGFKCDLSQLPPPANRTSFADDISDGADSWDGIVELTDRILARLTYFGVSISALKSKFGKTATDFLGHVPIYRDLLDLASCLYEISDEELRLGLVSPVAVRAFADLKAAYSSTPLLCHADPEREFHVLLYTTSWAISATVCQDYDGVLHPVRFCGRTLKGGEPRYEEWAKEALALLRAFTVCYYELRNMQLVVYSRHGLLKWILADKHGKADHLPWAAILSPWTIRVEQVVELDERWALPIRLMDILHPPDASTLAEMDVYKPNKAKDIQVSQRQAALPRFGPDERATVVTFDGAIKAKEKVGSYGFVIWQLPGWSVLWAENGVFADATVNLAEYNGLIAALERVLSLSVVNPVIFGDSRLVIHQVLGWMQSKQSHLQNCLDRVRALRDQATGVEFHHVKREWNGAADLLAGLALQDRSGGQVLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X7D7</accession>
    <name>A0A6G0X7D7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_007852</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000093">
        <property type="protein sequence ID" value="KAF0735848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X7D7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014389"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052050">
        <property type="entry name" value="SecEffector_AnkRepeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586:SF3">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0735848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="386" mass="43134" checksum="EE1A8523E36D2E4E" modified="2020-08-12" version="1">MAVLLHPQLLRLVCEFQDGVFADLLPIPLRSFDEKACVYFMMDAKHHTLAFLANFHDTYAPWLRLHPTERDVGRLLRCRPHLHDVIAAHAAMYGQLYLLQSLQPLQLPFLLKLAASNGQTDAVRLLVSKGCTTCSSESLDGAARNGHLQVLEFLDETFSDTARCTTDAMDLAAMNGHLNVVKFLQTKRREGCTHWAIDMAAANGHLEVVRFLHENGAPATIDAMNRAARNGHLKVVQFLHYHRLEGGTARAMDWAAMNGHLEVVKFLHQNRLEGCTTCAMDDAACFGHLEVVKFLHEHRQEGCTTFAMNYAATNGFLDVVRYLHEHRAEGCTSLAVNQASRNGHKEVVRFLRARYPEPCGGKWTVRIEEICAGVLACSLVAWAIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X8D9</accession>
    <name>A0A6G0X8D9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_007331</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X8D9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020394"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF206">
        <property type="entry name" value="HSF-TYPE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="5">
        <location>
            <begin position="6"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0736311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="178" mass="20536" checksum="432292F0FB233C74" modified="2020-08-12" version="1">MTFDAVAPLFIRRLYSLLDEAPAKIVSWAPDGQSFVIYDVAGFATQVMPHYFGHQKLATFERQLDYFGFHKCQLPRDAMEMEYCHLDFQRGNLAGLATIRKRFKRDLDPDDRAVVDEIEESILQIKRHVEQNKESLRLLLDCLADLNQDDMPETTYSHLSPRGTHTMAPPPLYLGSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X8G2</accession>
    <name>A0A6G0X8G2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_007197</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020556"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1000.11:FF:000002">
        <property type="entry name" value="Cytohesin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF388">
        <property type="entry name" value="GOLGI-SPECIFIC BREFELDIN A-RESISTANCE GUANINE NUCLEOTIDE EXCHANGE FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="2">
        <location>
            <begin position="508"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="919"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1399"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="931"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1407"/>
            <end position="1429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0736174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1429" mass="160164" checksum="2D6DF0F28F6D1935" modified="2020-08-12" version="1">MVYGHPNGVNCLKGEIHNVLSVMRANDRWATAARFKREIPTHTQNVLIRRFKDLHVALEGVIDLSDVDTLNVLEPFVHVVESEKTSGIITGAAISSLNKFLLYGLVPPDGLRATEAINRIALCVSRCRFEETHRDIDEMVLMKLLELLEFCLRCEAGPLISGDNVWKMVHTCYSICIQPRASMHLMHMAENTLAHVILTVFDRIAEMDTSLVTNNPEDDEGLQGEELSAVVLPYGIPVLEQLLAFMSDLIKPKGNQDTIIFGLSLINLVLETAGTGLGAHPSLVSVLQGDLSKYLLQNSETTELPVLGLTLRVVFNLFNSIKDHLKVQLEIFFTSVHMRIMNHPACSHEQKELALESLLEFCREPALMLDLYINYDCDVHCTNLFEVLCTALAQTTQVVYFPELPPVFNILNLLALEGLLAVLESIARRCPLHHGSSKVDVTGSELAAFVDAPLSSSLTLPAISPMSSIQEVMHLVMSDTESDSGDASLPANDSLAWLHTARERTAEVLQQRKQNKKRCFLAAESFNSETKTWIAYAQQLGLLPNPITAEAVAAFFHQTPGLNKVLVGDYLGDGPKEDKPFHEAVRNAYVAMFDFRNAPLDGALRMCLSKFRLPGEAQKIDRLMEVFAKEYFNQIQNENHPFAHEDCAFILSFSIIMLNTDLHSDNIQKKMTIDEFVRNNRGINAGQDLPRDYLVLLYNNIKNNQIQMQADIGDIQSSTVGVYSEQWDGILKRQENVVGASFTSNASVLKLRAGRHEKEMFSLIAESTTESILNAFERTCDETTMQKALDGLSNCIKIAVYFHMIPEFNKFIAALAAYVVEFAHGILNGEKVHLPLGSPTSPDDLEDDRASRLKTTRALKALNVLFDIVVQHADALTVASWTCVVECMLLFNTLDICPASLVEMDDFVDVRGVPFPPSQLSPKALHSKSGKLRERTRRLAERQAAHRQTPMHSSSMAQPSFWDSLSYWWSEEEQEADANYPLVSAALREAVANCGQGLLEREAWLKFCRKLNSVEALLEALLNRPVDDKDKGDMVQENAMLALEWSTNVVLVNVHRFTTLWPIMHSYVASVLAENDKPLLVERVVVNVLRVCIRLFHDPEARPLLLDTLVLLKSLDSPMWQVLAERVATGMQLLLKANLMYMQTLSTQTWEILFGLLGIVAQYPAGWGATLEAIRQLQQDGSMPKELVGLWTGVCMRLINQRTGVEGESLKLLYSVANSEAAESCWIDLMRILLSYLQDERPAVAKMSWDCLYRSLMVPGVKLASPVWKDCFEEIIYTLDDRSRHGTSKDTRDMSLYSTTLLSKVFLYNIHTLAELDCFDDLWLNVLTRLATKLQTPPSVSSQQDVEVYETTLHSLHNLVVVMTAEGIFDERQKADLLLRSHEVIRSICPHVMSTFGENDGDVPIDQSAAPTQEEQQEEQQQQPQPSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X8K4</accession>
    <name>A0A6G0X8K4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_007237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X8K4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017257"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12242:SF22">
        <property type="entry name" value="OS02G0130600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12242">
        <property type="entry name" value="OS02G0130600 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0736214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="261" mass="29872" checksum="2AF6431375C4A2BC" modified="2020-08-12" version="1">MWQSYVDAVIIVIVVAAGFWSIRRFPPPTTEITTPRTSSFNFLLIFRSLIVIANLVSLIGYSGLPRAFRYYTLWNFILQTIYYVLMLSYQLRHRNESKEVPTDTEFRALNTLFDICISVSFLVCLVFWAVVHPTSPGQVITLNLVYQHGINCVLLLIELAFNGFVVRGSTFGYTLLFPALYGILSWIGHETWLNGVWPYKFLDISSPASPGWYIGVVLVHPIFLWVAIQLSKLKRRFRPQFCPRSHEEALASVITPKDSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X9D7</accession>
    <name>A0A6G0X9D7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Plastocyanin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_007119</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000088">
        <property type="protein sequence ID" value="KAF0736669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X9D7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004067"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13844">
        <property type="entry name" value="CuRO_1_BOD_CotA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48267:SF1">
        <property type="entry name" value="BILIRUBIN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48267">
        <property type="entry name" value="CUPREDOXIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026064298" description="Plastocyanin-like domain-containing protein" evidence="7">
        <location>
            <begin position="19"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="569"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="604"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="671"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="776"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="821"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="855"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="882"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="137"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="432"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0736669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="907" mass="98149" checksum="CB8457B32B6A2566" modified="2020-08-12" version="1">MRTTTGLALFAWASAVFGQDTREPTSGEKLFGQWQAFTSPLVIPDVIDMRKGGNLEMNIGETIHAWGSGSPNGTTYGYGKVGGKIQTPGPTILVKKDVPIDVKWINAISSNTHLMDQDVESTLLIRESACYPNCGVPVVTHVHGLENPAMYDGLPHYSIYRNQTYTAHYNNTQSASTKMYHDHAIGLARLNMWSGLVGFYVIQDEELEAKYKLSNLTDIPLIIQDKIIYPDGTLVYSTVATCQTPGTKWVSEAYGAVNTVNGVVMPYVEVPAAQVRFRIANMANARHYNFSFPFADQCKLIATDSGFVGQPEAVNGTEFVVFPLERMELVCDFTSVAPGTSYNLTDTPSADSSYPYDPRVVQIRVVAASANTTKVELPTNMTAFKDLQALYKSTGGKLRTITLAEMDDANECPVQLMVVQHQLVANVSTINNKLMCTLGKVEKWQFKNPTDDAHPFHWHLVNAQCGPDDNSINKNTLKDVVVIPNDPNSQKIMQVCYVACTPDQFLIEGSTVGPTDYGFSTDDPYLAHCHIMEHEENSMMAWFQLTKEDDAAPIDDGVVLTNKDKVTSAVIWCAMGMSVLGGFATCLSVLVLSIKRLNFLAGDTALAVTFALSSGVMVFIALVDLFSEAVERFNNTWAVGGTADLESIEEGLAPAGATSPVCDKTCQGHSYLAVVGCFFGGVMIIVLLEYVIHKVFDFHAKRLGAQLAAAQHNATAAAQPVEEGEFIKTPAGRAEDYDELTGEEDSLTEKQADENLGRAGVLTGIAIAIHNFPEGLALFVTSLQGLRAGIVLAVGIVLHNFPEGVAIAAPVYYATKSYRQALFWTSLSGIAQPLGALIGYATISNGVSDATIGVLYALVSGMLICIAVKELLPGAFKFGPKVFTVSFFAGFLIMAISIIVLKYVGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XB38</accession>
    <name>A0A6G0XB38_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-adaptin appendage C-terminal subdomain domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_006543</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XB38"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021744"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015151">
        <property type="entry name" value="B-adaptin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09066">
        <property type="entry name" value="B2-adapt-app_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-adaptin appendage C-terminal subdomain" evidence="3">
        <location>
            <begin position="263"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0737376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="377" mass="43176" checksum="4701AFFC1FD2E31A" modified="2020-08-12" version="1">MPREPLPRRSFQYAKPRKTVEISYEEYTHNKNEILSKIYRRLFWLACLATAFGLIALVLYIIITSKYANAVEYRRPVMGVALKSVYMIYWGACAAVAAHGFHLHLKWRHFLEDGTHLVMHCRLFEVLGLWWFFSAGWLLGGILAAFGFIDLSVISANVPNIMYAVAVVTLVLQFILCPWFLKTIHSKTTQIDDILGSEFLGKTRFRNVNVEPLTDLNDIPSGRDDGSDEDKENSNKEEESEQEEESSEEEVRGPATVMFALDPKHKIKKSDFWELWKSTSVAGSFSCNFRNKPPTLADVTKHLNAQGFHVVSSNSSNDVVEIFLYGHAVESSVPFLAEFIFVYPRQFFQTTFKCESKERAADFVKEFQLHQLMDTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XCL6</accession>
    <name>A0A6G0XCL6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_005902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0737905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XCL6"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0737905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="107" mass="11661" checksum="0AE4407208EC9E5B" modified="2020-08-12" version="1">MHVWPRSVPDGLTSCITAREKLATGPRGGQFAGSLRKPSTTIVAARSLPRRYPPNRPEPIEATLSAVRGQPDKHTTLLLMFTLIQRPVLGSSDQDSSPKQPGHVRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XD77</accession>
    <name>A0A6G0XD77_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_006103</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0738116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XD77"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004731"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026163345" description="EGF-like domain-containing protein" evidence="3">
        <location>
            <begin position="27"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0738116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="138" mass="14994" checksum="45EBA92AC35C1421" modified="2020-08-12" version="1">MARPPPPSVVVVGFLWLLSWASMASASVIACVAGDHNCSCPVAYDCSYDTVTNNCSCAFKQEITIGLVTGVFVLGMVCFIRARKLRKKKHQILRAKSIAKILEVGHDSKGPRITHINPASKWNTRAPPPVKLHSIAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XDJ6</accession>
    <name>A0A6G0XDJ6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_005854</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000077">
        <property type="protein sequence ID" value="KAF0738296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XDJ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012107"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0738296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="84" mass="9065" checksum="442810B2D039890F" modified="2020-08-12" version="1">MANSAAASVVVVAAPSQDIPIEKRKIEPEPTSQNKRVKVDTKAAGLWVQRSIQLGGQAKPVLRKSASVNNLWVKQSIAFVSRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XDZ2</accession>
    <name>A0A6G0XDZ2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_005840</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000077">
        <property type="protein sequence ID" value="KAF0738281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XDZ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012122"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
        <property type="entry name" value="FYVE_like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05123">
        <property type="entry name" value="STKc_AGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000717">
        <property type="entry name" value="AGC protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000465">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053858">
        <property type="entry name" value="Arb2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045270">
        <property type="entry name" value="STKc_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22749">
        <property type="entry name" value="Arb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="480"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="21"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="847"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0738281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="889" mass="98055" checksum="5198C11CFE9C102C" modified="2020-08-12" version="1">MHNSGVGGNLLSNSDIYHIKRMSETRQSTSRESKNSSRHGDDHQAQSPPDPPQLRATNSSGRSSTSSKGGNASDDNFSINAPMGGLKLDYAPPPKSYSGDSTAESARMQELVKRIHRDMVSELGLVEAHVPFEGDEEAFQEHPCQCKSATVFHTAHYETATRLIVIVPYREAGIWSRSICLNSFASPDEDAGNMLNYLRKAIAEGYGVLIMNPAAQACHTKIHVGTVWDHFVKPFTSDLFILAHSRGCQNVMQLLNHDNGQGGMQNRLRALCFIEPSHYVSDKDTYFARRMLSRRAVSWILSLDIPAGQKITEMEKRHGCICISAGAIPSNVQGSSGGWAIRAVLTAVFGVFAARCGQSSGVTKMTQYDKSKNGGCGLCHRKMGLLTRKTQCAWCEVKYCGVCCEDKNVPNFKLWGVCKLCQVLPCLIDPRKKASAGASAGASAGVSAPTSAMTNDADLIDRCSIFIQPDKVDDLCLSDFEIVKFIGRGACGRVKLVRKKHGADEGSFYAMKSIKKRLVVARGLVAATNAERRILDRIKHPFIATLCYAFQNEAKLYLLSNYYPGGNLLDQMRLVRNFTEERARLYAAEVTLALGHLHANDIIYRDLKLENVLCDSEGHIALTDFGMSKENVKATDRTSTFVGTYQMMAPDILTNKPYSRAIDWWALGVMVFEMIDGRTPFNAKSNQLIKEKILTFEVPFSDRFSKEAKAFVQALLQKKPENRLGCGPDGVKEIKRHPWFASIDWDQVLARKATFSPDQATLMKTYAKEYVTVDVFDTYMHANEVACDTPTSVRGTTDVKDLFQDFDYNHLTRLSTSSDEDDPNDVATVGHAADPDFDIQLLRPDVITPKDEGSDHSSSTLAASSEDEVLSPVKTSSSIVPSDCNVTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XE44</accession>
    <name>A0A6G0XE44_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_005685</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000074">
        <property type="protein sequence ID" value="KAF0738454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XE44"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021399"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004156">
        <property type="entry name" value="OATP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505:SF9">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03137">
        <property type="entry name" value="OATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="495"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="526"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="559"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="605"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="30"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0738454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="652" mass="71734" checksum="1FAAFD3B2F113545" modified="2020-08-12" version="1">MEDAPLLPPPPAPRRRGKSKAALRREASYIFKYLLFAQVTVYLETGTIPCLLDAFAAVFDMNAREQGWLGSVVYIALCAASPLSAIAYKHVDAKIVLGVSLVLNNLCVLGFAMTPTGYESSSLMLITMRALIGFTQSFLCVYTPLWVDAFSPRGSVAGWMSYLQGSVPLGVMFGYLFGSVSNWVSIDECYIQCWRWPFLLQFVLVLPLMVGVFFIPSEHLSIRHAKKHTPANDTHPVVLEEMVRGTRRSLSNLSYSFRDLDLNPAQFTAIRASYTTPRFRMDAYDIESLFLDEPDENSTMSPSTYGSIPSAHPPVSIESTYHTAFSHIDSSDGKTTSSTRGSLDLMPLSISEELSPLNEVDSALTSSYALQAAAPLSRHSHRLNELDEEEDEDDDEVEDDAHLDDLDIVQSFIVLLTRPLFTLIVLGLSAIYFVVTGVQFWSTIYLQKNFDASVVIVNGLFVVVAGTGPIWGVFFGGALIDRAGGYMGLRQRAKALGICVGLGFVAFALGVVTTFLPSLYLQATSLWLLLFFGGAILPSCTGIFISATPIQLRSLASSISVMVFNLLGYALAPALTGSFMELIHNYHEDPTSYWFGCDEACMYRVGFRCCLAWSVWSLLAMLAAYMVAKQQASKSTQEESVAEQGEIVVMMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XEF2</accession>
    <name>A0A6G0XEF2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_005516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000071">
        <property type="protein sequence ID" value="KAF0738588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XEF2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012950"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0738588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="351" mass="39762" checksum="BBCC71468F552761" modified="2020-08-12" version="1">MTSTPCTDLCLSSVTTAACNRSETACPTCVFPRLGIYVCTYNCTEIGATICPAQLNATTIFVEPTITTMAPTEQPTTQLPSTTENSSSGALIPGRLLLILLLVSGSVCVLLACCAWMYRRKVIRERENNNLTIVRHDPTKSYNPTLAHAKLDLWNDRDSSFLRKSTTQTQSTSGWLSDLFIAPSPQGLALPKQVEEQDPWLFTNPYRRSSVVDLLQPHPEEEAVEIATPLRTLDHIVIYKPLYQVTHYCHNELVGILKQRSSRTHENKLPFSWTYDRSSPSCLEILQTGGEITRKARRWLDLSFFSEDKLSIFEPQEAGNERRGVALVDLEYVIKRMIDELFFSRRRNRQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XEN1</accession>
    <name>A0A6G0XEN1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_005335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000070">
        <property type="protein sequence ID" value="KAF0738713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XEN1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001978"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="488"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="746"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0738713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="772" mass="86607" checksum="56776877AACD22BC" modified="2020-08-12" version="1">MSKTPLATKECFDEDDDSYAHRRENCWRSLCYATARKTIFLVVYVVTTLATSAVVVSWITDAIAARRSAVAPFSIDIASNVMSEYETAYSMCIETAIQESFGEAIEHWQSQQTRFLDALEASKVAMDAIMTQTKQCKDVLFQAQSSFKAVNLDCEMDDQLQLETMSNAWSLRQPASESWVMIQVRPPLHPKVADQVAAAVADAQLRVVKDLNATTHSLGQVVDMGKEQTDERFDHLKYMTGKFKKSFELPGGNGKSTSFHQALEKAKKSIADARQIWDSVVPVVGSSSFPISHDVDASLDGMMQATESWASQLRELEALVNETSTNVNQWQEAVEVHVLDTKQILDELVLQIGNESSTWPTFANWTLRSKLLQQQQHPTAPFFPNLSMANLSLSMTKGLQGGLPLAEGWNVDIEGTSIALPIDLILRIFTSIAIIFLVAYSNYTDLPQLDNQGFTAIQTIGDWCGVLCCRFHIFDIVYSLSLVNLWPFFWTVFICFLLASLTFGVVVPVNRYHSMACADGDETSRNLGLSSFIVNLASNTVIERGNYKAMEGYFQLKTIHERTCSSYEMQIKSIGMQNQANLSAMLVDYDDIFTTVQQFRKCIPEKDPRNSTASACNVEPGVLVSMTSEAAWKCPDFNLTLAALKKPCTSTVMHDFKHIDGREQACRLERVVLEYISMVWVWWIIMATLNLTRAVVLKGTNVFLWRALNGGRIPFLGFTTEDGEMLDQDRLARRCKRQLTEYKVLRFIYCSAAMFFCTLGIVLTVATLNSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XF63</accession>
    <name>A0A6G0XF63_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_005428</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000070">
        <property type="protein sequence ID" value="KAF0738817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016796"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34894:SF5">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34894">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE RSMI, CONSERVED SITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="1140"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1442"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1468"/>
            <end position="1479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0738817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1479" mass="166413" checksum="DAA3937D530497CB" modified="2020-08-12" version="1">MLPHSLLPLTKSPQKAKLPTQREPSLTTLSPRKAKQKLKSNEIRGNEFTWTDHVNILPGNFAESQSNGTGTIQDILLFDQKLRDATPQPHEHHTKVNIHDWNMDPHADGSLSILTSNKRAFEVLTSDRGQRVIASLVKQWEADKYSDNGRSLWAVVETFFTKLPYVFVKEDEMNSKALLRYVSALATLKDVIVQALFCTNPSAAMAISATLMPTHNEKIPLYWYCHQLEREIQMLKNSTSDQSWEMVHSSDIGLLQQATAQALLTFWKLPKRERIAFLAQVFSNVTEIEADLVRVLLENNTFILQQVLEELGYQEKIAINKPKMSTVGAVVAMSLQVSNQARQLNKWRNRAKGESLEPIQVRHKGIQVNNTIEGEDVLGALEPLNVQLPNRIRRSVIPGDKGFQVVLMQDYQPFTRRDQTHLLAKDMWTVSTHTESLIHHLSLFIDSSREIKSVPPDVITLATLLLEWLHFERAKANSNAKDLTLEVFDNAHFKQCIVALMDLLKGQPESHVPDNIKWLAASLQGFVLRLQNQLPNSDSTSIPRAEASTATPADLRALLKHGFPSEIVNQILSISNEKQTKERESKIIILIEQLQQYLVDKFHRTFAKEANTPVGFGEVSSTQQQPITTSPVLKTLLDQMKCLLFDGSDGQLDEEQAASLMLEFLGSFEQRKNEKDSGGDLVKMLTIESLGNLFEKKVELQLLFGPLDKTTRSHIAKLQNFINKLLPENVSCTNLPKPTLSVTLKPNLIAELCTLVDEALAKKDVFGEKIAVTLETLKAIFQKTQEKTNGKSLEKTVQSMIEALSTLGDENLPDFISSFDDMITSLRVLLRSCEDPSKFRPAKTQSDSGSSSDDLVSVDTLVGNHHANSIPLSIIKLSKDLRIASDAAQIVSQAKLSISPTRKRSLNTDAQVLDPHDESQPRGRKGAGFNLFNLLLDNSRQKKQNVLGISANELSEMFIDNKTVLNVATVQKIIYQIYRERYECNLTEQDNPNTTAFIDFVYDWYLRKYGLRKLAMQHLSKLLLSLKKQKKKSKKALLFCRFLGLFPPLFDYSALNFALGLLNVWTNGTFTVSAAMTRVSLSAMNQILEDGYDRRFGPFCSTVLVKERLTRNACVSDPTSIEQDVALEIALDEFVKMKVNVESMLEDIYKAGDVNEDDAMGFDEFATVVRNLAPCVSDREIVKMFKEALLDSSFETITKNRFVNVIIDQGVLSSRVNKFKAPTGANSATFPEYEKEQFELLEETWRAHEAEIIKTIEQIPHKETSSSLLLRVRILNMIISKRIDSETAWLSHRMIIRDMERFKDLNESAISEIKKKEAFFKEAVTRITTSKFGLFGDNSKRPQGTTAISQTSPPPINSGVVQYVEQLGEHDEDEVDTDEANETDIARIEDSLRSKMLNLADAKCDTPIETQLNLFDDAVKKVRRLSMSRASKAITKLTSAMKKMGRNSGTLLTPAPAPTQKPEHSDSADDGDEDDDVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XF93</accession>
    <name>A0A6G0XF93_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cilia-and flagella-associated protein 96</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_005458</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CFAP96 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000070">
        <property type="protein sequence ID" value="KAF0738847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XF93"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013227"/>
    <dbReference type="OrthoDB" id="283553at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029358">
        <property type="entry name" value="CFAP96"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31144">
        <property type="entry name" value="UPF0602 PROTEIN C4ORF47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31144:SF1">
        <property type="entry name" value="UPF0602 PROTEIN C4ORF47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15239">
        <property type="entry name" value="CFAP96-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="15"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0738847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="330" mass="37243" checksum="E79E94BB2BC15ECE" modified="2020-08-12" version="1">MAAMRLDGSFGEPSYISIGDPYKNPTEDKVHHIPGSKQFLTTGPKEGQTGSNWGPGPRKFVGLSGSYQEAYKLESQYRLENTKKNVKPNGFVFSCGKGDYFGAFQKPDPDEEATRATAIAQQPETRINPKERQFERRNVLTSPVKKGTLGYTGTLIGGKSIPAMAAEFDSVRNAARKDMQYHKEKLGERKAFKSMSHELDYFDTNDHVAASRVYEWDDDCVKKPPEREELMNPKERAMAHAATYKSWKPTHAGKDGEPGTFEKFPERMPDPYDERVVTRAMLPNRRNPVEVATADLPESIRERKAFKPSSFPKKKFTKSTCLLGINKHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XG05</accession>
    <name>A0A6G0XG05_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphatidylserine decarboxylase</fullName>
            <ecNumber evidence="3">4.1.1.65</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_005176</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Phospholipid metabolism; phosphatidylethanolamine biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000067">
        <property type="protein sequence ID" value="KAF0738986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XG05"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007224"/>
    <dbReference type="UniPathway" id="UPA00558"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033177">
        <property type="entry name" value="PSD-B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF6">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="400"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0738986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="412" mass="46741" checksum="FD579491D24C4904" modified="2020-08-12" version="1">MNRRILRSKFKSVRFQSTKATGRKETKPQPRSSVRSSPGEKTEEEEKLASEPQMFLLHLVSYCAISRLWGAVDEIELPNFMREPIYNAWTKAFDCKLDEMKYPLQHYKNLSEFFSRPLKDGIRPINWDPHCMSSPVDGTMATFGAVDFTVDIPVLEQIKGIRYRMDEFLGAVPDFFLAPPSPGKKLFHCVIYLAPGDYHRVHSPIDWSMGERRYFPGELWPVNKIAVTSIPSLYTWNERVARLGRWNHGFFAMTHVGATNVGSITLDVEPEFATDTALSFYFRDWGKCYTKKYESQELVTRGDQVGQFKLGSTVVLVFEAPEDFKFTAEPGDKVRYGASIGHFERAADADGSSSTFPSTSEMIRLANQGSDEKKTSYLGEISRSISQAFFGSRKASADLQTDKSEPSAEETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XG52</accession>
    <name>A0A6G0XG52_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_005148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000066">
        <property type="protein sequence ID" value="KAF0739227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XG52"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013188"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="31"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0739227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="325" mass="37837" checksum="43DBE331A6EC0F42" modified="2020-08-12" version="1">MNSCNDVESDSSDKAEGARPKYFQCKQREYRHRLKNERACLLEALALFQEESKQSKENLHRLQDLVDSNSSLIFEIMRFLRACKPRPGPIISEEQPMNYNVTLMANGAARLHAKQWLVQQLYHNTSRIFHNFPVTDASDEFTQIRAECSGPWVHIVERTQVLFPYPLEDIKRFFLHPQSQEIICLTDEIDVERDGNTVLAHGRFNDAVGWHLLQGHFFQADRFVVVHRHIYDDEAVEGSGDPDYHEMEWFDVRRISPTQSLVRNIGHRTMLIKDVKEFATEMGATVTTHDKKTTERQVEAFSRHLSTSFQTNMSKMLVYCRSSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XGD6</accession>
    <name>A0A6G0XGD6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ae201684_005157</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000066">
        <property type="protein sequence ID" value="KAF0739238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XGD6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003201"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0229">DNA integration</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="13">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="14">
        <location>
            <begin position="285"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="552"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="555"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="608"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF0739238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="644" mass="71408" checksum="A89C631A0C0A08C6" modified="2020-08-12" version="1">MFSDVNSNFEAKDVETLKRRIEDEERRLRTARVRQANRIQDHALRVDQVKCYKCHGFGHKTPDCPSADAFDIEGNVKSNNRRGGFKKKHVKQASQAQSDGANLILNVRSSVKDYRSAWFGDSGSTIHVCGPMHRHLLHDVIDLDVPPSSKLVIKTPHGTRTITDVHYFPQSGVSLLSLVVLHDRGCDYGTVGSNDLVVTKNDVEVLRFRKDGPLYELIGKLVPPDRVFLAGDIDLWHRRLGHVSQDALHKLAIAGFGMPDLTRQVLGECDLCSRSNLHRQPFNSAKKQPDLPDTVSVDLLFFSQNSRENHSCALNVVTHDHRLSYVAPLRSKSEALEEFKRFFAYYKTQLNTSIKHVKSDGGGEFAGRFHDFLLQNGVEHHVTPRETPQLNGVAERTGDTLGAMTRALLNDSKLPRGYWSDAVVCAAYLRNRLPSAALGYKTPIEVFTKRKPNMTFLRRFGQTCYAKNPDGRKLDDRGTKCILLGFGPLGYKLLEIDGRSGRRVIYRRHCVFVNDATAVVDDDDVSDAIPPLDDEQMDVDDEVPMTHDHVDVDVDNVSSDGTNVNSNGATACDNPLDSFVNPAHDYSEPDVTAEAPAQDTAAEDGPTTGHGGVNNGGDYDGGDGDDGLEPPLDVPYGRFDDPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XHG4</accession>
    <name>A0A6G0XHG4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_004866</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000063">
        <property type="protein sequence ID" value="KAF0739698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XHG4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018161"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48037">
        <property type="entry name" value="ATPASE E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48037:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="11"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="155"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="271"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="400"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="275"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="359"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="424"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="493"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="504"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0739698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="521" mass="56407" checksum="2230530E18EB5612" modified="2020-08-12" version="1">MPFKARSTDQNKLIVVGIAKTVDDAALSDMFGLYGTVAEAKVVLDDKKQSRGFGFVTYTSAAAKNKAIKHMNQTTVDGRVLTVRDVIPKADREAKKEEVAAPKTGVCWAFQKGLCDKGDACKYPHEVKDGEYGSCFEFVQSGKCKRGDQCKFSHGGTTNANGSTTEKPKSTASNEEPAAPPADKPRVCFAFQKGKCHRGKACLFVHEQLELPKGTSEGSATDSKKRKRDDQEGAESLEAQLTALIAAEEKAYEEYEAAKAKRQEVELQIAQARMTKPDKTKKAESKKTTLGDKAVKVKEEIKQEKTTIKLEKAASTTEKKPKVSSSTGGEDKKKPADKPVKKQAEPIKVEAKNVQQATGDDDSDDDDEVVPAFEAASFDDDDDGADFSLSAIIQNAVSEMKKADAASTVYDSDDTEELPRKAAKASTKPSKPAAPAKAAKKQAKPVSVTPVRVKDEVDMGAAFDDEPPKKKAKGLNGAPSPGGGERLKASDHRKLRQLKKKQKKEALARLKSKQEIQVDHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XHI2</accession>
    <name>A0A6G0XHI2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_004826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000063">
        <property type="protein sequence ID" value="KAF0739654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XHI2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001215"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026202626" evidence="1">
        <location>
            <begin position="20"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0739654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="179" mass="19734" checksum="4B155706C4F599AB" modified="2020-08-12" version="1">MRLTSLLLPLFVASRLTFAANSVQWVNVTGFWFSPAGGNSTHVNAMSENDCLTKAHSPFANYNNVTKSCYAIDSCRSFITDVSSTTAHAKYDPRVFVCYGNRELNGTVIERHQEALGFTECMAKSAAPYDDQGKRNKFNVITWHGEAKNGTSVGTCELKAMTSVSKVDRRGVISCKKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XHS8</accession>
    <name>A0A6G0XHS8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_004815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000063">
        <property type="protein sequence ID" value="KAF0739641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XHS8"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0739641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="152" mass="17726" checksum="CEFBDB344407B03F" modified="2020-08-12" version="1">MLYHLCLRGSLDLNRTASPFREKRHLELEASDILDVDDLGRIRIVQRSRRSRTECIPRRGFIVRLKIAHNVLMAEHVDTAFAALGTQNRLVKECKNVVKSQRTHISCNVLTTGKHISFRRDFFPKSGAFFRGGLWLFKKRINYCLNVFLRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJ92</accession>
    <name>A0A6G0XJ92_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_004105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000052">
        <property type="protein sequence ID" value="KAF0740367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJ92"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019452"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031930">
        <property type="term" value="P:mitochondria-nucleus signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47936:SF1">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN GUN1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47936">
        <property type="entry name" value="PPR_LONG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0740367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="744" mass="83994" checksum="DD0957D9F571D0E4" modified="2020-08-12" version="1">MKSDISKVNAKDMVRMWQSSCRHPDLLPDVWATLEKHFPREITQEVLDVTCYAFWMHGRTTDVISLAKTRNVSKLSVEMVDLIIRAHLAEKNIDQAEDVLASSYPNHMTLQSRLLIAYASQNNVAEVQSILERLVQLPAPMWTPQGCRNVMSALGQLRDVPGMFEFLRQMTDSGIMPDAFIVSSLLDACVATNKSAEVAQLLQNLPNLDLERQPALLQACINAHLHVENFNAIPALVDELKALPPHPSTERTLRHVITEAVEAKRDDIVTIVLSPTGVSEFLFTYVSQDPSLVHCILQHTEHLTILYEWNLVLAACLHIQEYRAALEIFVQCPLRPDTTMLTTIAQCASAASISKKSDPVCVQLVTKCQELVRGPSSLPMFASRRAALMELCNAIDRPDLVLELLPSAPIDWTKPMALAGMNAAAALGKQRRLQEIYSSLGHRLRDDQIEAAFLEHRSSLQSSRLPLPPRLEAVFTLVQERDYTSAQRKLRQLVKQGISPRVWDAFIELLVQEEQWSFAADVCLLLSRYTQVIDLFVARVETTPQRPWIPRSVAMLQLHEACQGVGEEDLKIVRQKLEQVLVDLFDGYEEAFQARHLLDFMRLATEIHSPDLTLRFVPEQAKKWALPMVPLVMSAAAQTNQLGEIVEKIPEQLFQEISAQRAYVLSLLQCIPVNWDAVVDAARNLARRKAHWPIQTHLLDEMATRREFARVLKLRPDISINSLAEHESWVEFLDTLAPPLEPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XK30</accession>
    <name>A0A6G0XK30_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_003864</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000045">
        <property type="protein sequence ID" value="KAF0740732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XK30"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0740732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="89" mass="9914" checksum="31072EB69D7A0A8A" modified="2020-08-12" version="1">MPLRVHSSVVAKIPMVVFASSPVPSTRCSRDVALFPLSVVSQFLLWNTIKPRMQGKKLSKIAEEQLQDIGSQRMDLKLLREVDHVGVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XKH8</accession>
    <name>A0A6G0XKH8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glycine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_003866</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="2"/>
    <dbReference type="EMBL" id="VJMJ01000045">
        <property type="protein sequence ID" value="KAF0740734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XKH8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019037"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006426">
        <property type="term" value="P:glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044281">
        <property type="term" value="P:small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00858">
        <property type="entry name" value="GlyRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000002">
        <property type="entry name" value="Glycine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00253_B">
        <property type="entry name" value="Gly_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022961">
        <property type="entry name" value="Gly_tRNA_ligase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003211">
        <property type="entry name" value="PRK04173.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745:SF8">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="GLYCYL-TRNA SYNTHETASE/DNA POLYMERASE SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="9">
        <location>
            <begin position="166"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0740734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="486" mass="55103" checksum="E16AE5F2B6F6DC59" modified="2020-08-12" version="1">MLRPKVAAAGARSALRLQLRQKSTAQSSVNLQEKVVTLCRHRGFVFPGSDIYGGLANSFDYGPLGVQMKKNIQDAWWKHFVQSRTDCVGLDSSVILSSRVWEASGHIGNFTDPMTVCKGCNSRSRADKLIENASDVTGVKDAGGLSCEEIDALIAEHKIACPTCGSPDLQKTRQFNLLFRTNMGSTDETSEWVYLRPETAQGAYINFQHVVTTMRRRLPFGVGQMGKSFRNEISPGHFLFRTREFEQLELQYFCHPTESDTWFSYWVDECFNWLIKHGVKESNLKKRIHDQAELAHYARATTDIEFLYPFGWSELWGIANRTNYDLRKHMEASGKDLNYVDPTTKESVLPHVVEPALGTGRVMLAMLLDAYDEEEVNGRPRTVLRLHPDIAPYKYAVLPLQSKGALAEKAQEIYVKLTKVASCDFDVTQSIGKRYRRQDEIGTPYCITVDFDTLEDGTVTVRDRDSMEQVRIPIDTLLSGQWQWTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XKX7</accession>
    <name>A0A6G0XKX7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_003791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000042">
        <property type="protein sequence ID" value="KAF0740902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XKX7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005279"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0740902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="39406" checksum="4BF3CBFE5BD79C6F" modified="2020-08-12" version="1">MYNRIKKREQRQREKEISAEYSILEAELARLERQLAPDLPGCISPDGMLSWQTVSSVFQRERIVSEINRQKLHRKTSGLQRQIVEMMRLIRHEGPAWSLSPPFTIFHYVTLCADPDSRTMAKEWLAQQMYHNTDRAFANIPQILLPNDEVDEICFLDPYVKFGSYSYDVFPYPLKTVVAEFRHHTNSIWQFDETSLKHETIHNTTLYQTVTKRNNYFTVLVGVFHEADRCVLVVRHIHDDETFPSAGLTQRHDMEWIDLRRLSESETIARSVSHSSQPFNSDGLFSVDQVAKMSNIELPPGLLSEQAKWDAFNKELLVRQKSSSGAAHRRVIDVMAQLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XMQ4</accession>
    <name>A0A6G0XMQ4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_003338</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000036">
        <property type="protein sequence ID" value="KAF0741665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XMQ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017655"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017657"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46763">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46763:SF1">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="106"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0741665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="427" mass="48120" checksum="C98D017D1D7CAADE" modified="2020-08-12" version="1">MATDSAADLDAILRARIRNAFEMFDKDRKGCVIQEYVDGFAEAHEGNGRREVSTIMRYLGAYPSEKDIIKKILPEMQEDEPSTFVTYDKFEKKMLEVLYSHEYEPDTDETVLAAFRVLDADKKGYIDAEVMKDLLVTKGTPFREKELEGKSLFAELSLSSIIQWKGIFQIASRRVQRAPDRTCSPDTSCMATFVGHRCILASLNEQSKHARKGESPVCSMASCRPIMSAAKPSFRDIVVRSIEPCVRPNLAFVEYAVEMANQKTGLVWTIHRRFSMFMELQNAIDALFGTTHCVHCTELNDRVQQLELPPKWWGLTRLWGPTEADLKLRARMFASYVSGLIQLGATKMYRQCPLVADGYLHLVMSFLASMSNGGEISKIEQKTAPRAPPASESSSVKPVPPKMIRRKSSGKFKALETIFEQDPAVVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XNH9</accession>
    <name>A0A6G0XNH9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Selenoprotein T</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_002904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000032">
        <property type="protein sequence ID" value="KAF0741962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XNH9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004141"/>
    <dbReference type="OrthoDB" id="60822at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019389">
        <property type="entry name" value="Selenoprotein_T"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13544">
        <property type="entry name" value="SELENOPROTEIN T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13544:SF0">
        <property type="entry name" value="THIOREDOXIN REDUCTASE-LIKE SELENOPROTEIN T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0741962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="161" mass="18684" checksum="6F6322A2BCE7A268" modified="2020-08-12" version="1">MAPKSKNDKKSDDRIVIQYDKTCFAPHLKQFQEGFKNDFPHMTVDVEKYPLTTPKQTLVTFIFVIQLAMTTVFMFGINLLEYFKIDLDAATLKWFEENKFMIVPGMLMLSPVRQLISKTNAFEVYLNGELVSSTLNTRIIPNFPLFKETLEKKKGIKPVKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XNV0</accession>
    <name>A0A6G0XNV0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Disease resistance R13L4/SHOC-2-like LRR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_002818</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000030">
        <property type="protein sequence ID" value="KAF0742149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XNV0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004613"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF54">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="5">
        <location>
            <begin position="92"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="680"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="640"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="693"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0742149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="824" mass="94408" checksum="31A836C9D8A5E816" modified="2020-08-12" version="1">MCNLVGIKETATGYSTECLWDANMDMTLKPIAFAKAERDQWIQEKLQQHRKQKEKEDARVALEAAEAKERLWSPFGRAARFTNELNIAWKRDLDIFHWSRVLPFRELVALRVTGHGLTYIPTELAEQLPSLQVLTLISNALESLPENIGLLQHLSEVDLTKNKLKTLPASFCKLTNLTYLNLSNNALESLPDDFGNLFRLEKVWVECNKLSSTPPSFGKLRCHVANLSSNNFVHWDLHRPELCNLTTLTLNLNYLTSLPEVLCTLPALTSLSASNNALTTLPDTIGTLSSLRSLRLDWNRINELPYSFRHLHNLSEIHMERNPMTMPPLDVVYQGAQTVVAYMEQRYIAWLRQERRKIVEQLEAVLAALHRELYRADASSHNNSAGFDMLLAYFTAGIERVVRGTTLTFYALVLPALFTDILPGLSHHWQFHPKHRPSERDVPTDFFELPEAIIMDAITNFDDEYTPALVANQIAQFGRCGCIDPETKMRRPCNRVPAPFQCERADAALLRAKMVTTQEFKEMQSDSYLVARRIRLANAMQAKCVAFINSQEGIAFFDKTALECAKNLLADRTNREKQRKQQAKNEKLVEKTRRKTIMMIKNLESKQSRKSLSINKTVETLQRELETIDKQMRVATPAQAKKLDGRRQELVKRLNQAKSDLSRLESNPKLKMLQEKMQRLEEGLPEPNIRNNKSRDNDRGSNDDDNDQSEDSRESDNSQESSDNSEDSSADDGSSSSDDENDPANSFMAADIHGLEPIKNWIEAATEIIEGILDSRPNPKTHVEELVHFYNEHLRDTYTKEKMTKVKNKATTEFYQMRFVLRKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XP30</accession>
    <name>A0A6G0XP30_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_002814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000030">
        <property type="protein sequence ID" value="KAF0742145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XP30"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004611"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.30">
        <property type="entry name" value="POLO box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036947">
        <property type="entry name" value="POLO_box_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0742145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="264" mass="29187" checksum="E1FE9E9E621106A9" modified="2020-08-12" version="1">MLDKIANPTQDVPNPQPDSVEPPPVETRASPPPPVSSFVVEFKGILGATENSQSLICKSTGTSLELEGPNGERIEYLLAQGVIQGDLSPSVHFDCDFSNMPLLNLQPRVVTWMRVAQWCLAQSPVRTDRLELPQHMIESLQRLEELPSCLRKEQTESKPQSVEPTMKHSTPPVATAELAGIGRAESLEDGTLSLYFLDGAVLQVDDCASSVSYLPKDADEFDVFPLNSVAHEHMPYEVSRRLKYVSLFIQEMKKNNGVRSSTVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XQT7</accession>
    <name>A0A6G0XQT7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Potassium channel tetramerisation-type BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_002288</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000023">
        <property type="protein sequence ID" value="KAF0742894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XQT7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020173"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0742894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="15623" checksum="19193CEBDF7D8D9E" modified="2020-08-12" version="1">MSDPDLNHIQERCYDFQQAVDVIPEEAAVMKQKMTGWKEIEANSTVHWKRPENYPPERRWQNLQNLLGDTTALWGYTLHDSGQWNPDTPNAAFFLDLDASLFRRILHYLRTGELSLTDYVALSMRYCNPMKNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XS94</accession>
    <name>A0A6G0XS94_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Codanin-1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_001830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000017">
        <property type="protein sequence ID" value="KAF0743353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XS94"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012765"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040031">
        <property type="entry name" value="Codanin-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28678">
        <property type="entry name" value="CODANIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28678:SF1">
        <property type="entry name" value="CODANIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0743353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1071" mass="119770" checksum="52BB447BD2A38E30" modified="2020-08-12" version="1">MVDTVLDSEAAFEAVLGEAVWKACIKGQSAQIQRWIVSRSTCYEPKDLVGTNNNRKDSAGPSDFLSLGNEFETRLEELNPDQLVYSFLSHLRVHFKSGFKEQVDLSSSIAPPTTPTPTATVRKEKISKKRVPVVAVPNPPAPPPAWTTQDFPPLGGSSGSSKKSPPANHVAVTKKPQKDRRRIRSTLLSTTSLDAPLLSAPQDVQEVLLEKGVLEKFETRLMAPSAAKNSNQLPSKPSLDNHPNELLDTSNNSSPETEEEPQSIERVLEHVDHNLTPPAALYTFVLQGKLVPSTNIELQWLFSLLQKDDKDARQFAVSVLNQVSSWLEAYGVDILKLVIDAIQKANLASPLLDRFTAYIEKYEEFRATESQQAGTQLPVEGEARASNRNFAVPFREDTDSRLHFRTPEETVVYSNREKARDSFLALLRTWQSAQSSMTNRQDTIQPGVVLDELLSSNHWWFAQLFVTELLQVGINPLGENDRDLVAKIIGDDKLKNADRLRKLHQRLTHNQTKQNSLALERKVAKDDNDIDAAPFTDNQRFFYEFLTGSNRHEFSSLVATVLHANLVQILNTLTSLSPSSLRKNFNVMVLQAKLLGKFLGWLHFSPYWTLPQWTNNNAAMEAASREAIRMRNQIPVPLDINVYLEASIADHTLMAHIPWICDYLMMVTKDPIAVETTYFQKVFNRLQQVYCSPRLNASPSENTLYLMLQLEGLLRSKRMAQVQSPLDGGLQIQCQHMDAIPFLVNSLYVQSCVKDVAIFRRFLQTLYQDDKQSTSRKVKLRPYVVQQSSLLSVDSMEQPVASKADSALTIAFYKQYPSLQPTVEFVVDTVITNVCHFANTTILQPSAAAFVEKLLSQVNSSISKEDQTLWLTAQVRQQLPAAKIQACRQAREATEPYCRHHIPLAMEVLISPTIPTSVKSVAMNIATEKAIASLESMIKTSLAMEFSKHIVSRMRKLKKEVTVAPVATAPTALEQLYVLSKQVVNSMNNSIHEFASLVQSLPPTPAVMCCLVDTLPHVPINSSTKPAIQACMKHAFERGKPDFAAALASQLVSEFVKRDASHDEIVDLTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XSC7</accession>
    <name>A0A6G0XSC7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal lipase-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_001979</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000019">
        <property type="protein sequence ID" value="KAF0743290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XSC7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005937"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="2">
        <location>
            <begin position="140"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0743290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="898" mass="100099" checksum="601BC11EEBB68A8E" modified="2020-08-12" version="1">MGTSEDTSTASPPLTDFEFNMALALCDLSYEKNKTNMTYPGFKKHVLDKYDTMMKELGIDTKTYHQLPYIAYFDNKIRVIVANHGGVAFVCIMETNSLDQHAENLAFHAHPIVPRGHDDAPTMYVNNVTELGLVPLVHAMLRLKQLDKVVLCGHSRGGSVAHVVHYNLITNPNFCFDKNKEITSVAFGSTPFLRSQQPDLKHEHRFLTYVAERDVVPALFSAAVNSKIAAYVKAKHATKIGLVRYLMDFDIAFALERATEVLQGPLGEYLYYGKWTKLSQHHPPRHPGNGISCMQYSQTAIDEPLVWFQSVDYVAALDLDNVIETHSLKNAYKPHMHQAVEVPKPSVNLTLRINRHMTVPAARYLVHPDISPTLLPMLLNKAIAAAFVTKTFGDNEILHKLLEFKASLETYRRVFHERIQDKKSVDERLRDEMDGWNKLESRLKDIKPKEIQDTTPSKQEPSQPPNGSSTTPNTFNDDNITTEMNAMTIFTANMLAENPLESKRNAMGTVARIARAIALGVVGVASFGVALSAQAEAVAGYVELMSLIPAGIAVAEASALVGFVALGAGAAHLAQKGAFAAFANLFSIASGADSATANRVRSELYQESASSYQRQLDVIARAACPSYKKEMDTLALEELLETEATTDKARRNDKKLVARYIDVIRRIVELRRVCDNLVFIVLNGKQGVGKSWFIKAIKGQHGGPRVSTDLPEFGPYTPNGVADPTRSVYLIDLPAGDSLNDKLRLYLQELYGIGTIGINLFEFDVRPQLLTDEMFAMRQMYNGCDHVLVCLNKVMSKGLELKKNHAGSRAQIEGYLNTWRVFFKENNIKRPKYDIMLTDMTGTCEVRPSDDDDDSREFHDRWAQQNIDKLVSNGGSSRDQVIEWIEGKIAAILNRLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XSE2</accession>
    <name>A0A6G0XSE2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_001927</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Substrate-binding subunit of tRNA (adenine-N1-)-methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TRM6/GCD10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000018">
        <property type="protein sequence ID" value="KAF0743301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XSE2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007957"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017423">
        <property type="entry name" value="TRM6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945:SF0">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT TRM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04189">
        <property type="entry name" value="Gcd10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038170">
        <property type="entry name" value="tRNA_m1A_mtfrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="311"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR038170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0743301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="455" mass="51294" checksum="9E8365724EE76891" modified="2020-08-12" version="1">MSAAAGDVIREGDTVVCYTSDDRVFFQEVVPKMTIRIGKANADVKSVIEYAFGTIFEEKDKVLVPCEGGLFPDPVAPEVGEFEVPVNDNRSYTDTNDSQKLSNVEIAELKAQGVRGSELIAKLVENSDTWDTKTEFSKQKYLKKKQQKYMPRIQMVRCTAMSLCDVYHVRQPTKILNLRYDTIGQILSYGNIHAGAQVLVVDTVMGLITGAIAERMLGHGHILAGYEGQQASVDTIRRFNFDQATLDTIVYFPFHYIGQLNEDEAAIVSKESTKEENLTTPEEIKARKAEVAARVAKYSEEEQRKYAEKKALRKQKQAQQRPKRSPTDIRNLMRQPSDSLVIVSHYDPLGMLQQLLPCLGLSRPFVVYCEYLEPLAAAFDVLQRVDSIINLQLNDTWTREYQILPGRTHPEMTMSAGSGYLLSGIKVEATPPPDYVADLQVLPRRTNKKKRTTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XSU9</accession>
    <name>A0A6G0XSU9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_001366</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XSU9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020898"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09279">
        <property type="entry name" value="RNase_HI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46387">
        <property type="entry name" value="POLYNUCLEOTIDYL TRANSFERASE, RIBONUCLEASE H-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46387:SF2">
        <property type="entry name" value="RIBONUCLEASE HI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13456">
        <property type="entry name" value="RVT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="38"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0743707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="180" mass="19580" checksum="C803CEAF7128D446" modified="2020-08-12" version="1">MATRICVAKWRLHGVVASRTWMACFQQRYTTASTSTDSVRSFLLYADGASRGNPGQAGCGAVLATLSGDIVATKKLYLGDGVTNNAAEYHGLLLALQLARERAAQDVALHLDSELVVKQMQGAYRVKNVGLQPLYQQAKLACEGMSVKFHAVPRKENSVADKLANEAIDDHNSQERQESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XT99</accession>
    <name>A0A6G0XT99_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_001480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XT99"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002719"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00136">
        <property type="entry name" value="PDZ_canonical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="280"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0743834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="464" mass="51385" checksum="CD24A844F43DAC9B" modified="2020-08-12" version="1">MPRGFRHTFDESIVGRVSNLLCYPFKKEIPKPFHHTRQKNDDEQLPPRRRHSLPDSFRSYSNVDRDDDNEIPLLPRVVSFRDGSRIVVPPSHTSSSSAHSRKKWTILTTKWHGKKLGLLLENIGNCTIVKQVTDDADFDTNPDLRILQSGDQLVSINEESAILMGFDASVDRILSVKKPAMLQFRRRVVHQEVPRQPMENPFISYNAANDTYLGSIGDTFLMAPSAAAVDTKWSVVSSAPLLASAVSDIDSARQRLGKSEIYPLGSTERHKVCTMIKWAGEPLGIALQKNDDGEMEIKFCTGDGLAATYDCLAPGDILVSVGGVPVQSFALSTCLDFLQAAQKPVALLFRRHVGTNAEAAEPLPVPQDASVDAIVDVVRTTWTRENAEDPWRLGLQALHDKTLVVLLVTALPTERDGDVHVGDRLVAIHDVPVAQLGVDAALQWLKRATTVQLTFAHSKHDWMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XTH7</accession>
    <name>A0A6G0XTH7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SCD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_001494</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002732"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039662">
        <property type="entry name" value="Cohesin_Scc3/SA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056396">
        <property type="entry name" value="HEAT_SCC3-SA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020839">
        <property type="entry name" value="SCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013721">
        <property type="entry name" value="STAG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11199:SF0">
        <property type="entry name" value="LD34181P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11199">
        <property type="entry name" value="STROMAL ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24571">
        <property type="entry name" value="HEAT_SCC3-SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21581">
        <property type="entry name" value="SCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08514">
        <property type="entry name" value="STAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51425">
        <property type="entry name" value="SCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCD" evidence="2">
        <location>
            <begin position="431"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1174"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1174"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1196"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1298"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1310"/>
            <end position="1322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0743848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1349" mass="152683" checksum="1FD9D6DB172718C0" modified="2020-08-12" version="1">MPRRQSKKTPEKSRDVQDDADDVEDVDLTQEDEQVKTPNSQGRRSTRSSKVHESSSSSKDNLQIEVSTTNDSEEIGSQVTASAKKSNKKSAKQENQVSESSQAVVEHDDTDDNNGAENDPSTPTKPASQRRSARAHNPVPIYTTPAIGALKQTVNLADESPSQKKRKPTGRPPRPAKRTLNVSLSSSQKKSDESAAKKDSHDSDDEDSAFELFSAIKKGTCSTQDLLREWRSRFEKNADDAARELINFIMNACGSKVICVEEHDDLDDLDMSSFVESVVQSLQASKELSYPIASHAKVHRKFKDNFAEFWRSFIDECWDSELIHATDIVEKCIDWLTSLSSSEVRAIRHTATFAAYEIGCALVDRARQLRDQLVPINRQCAAATPESNKKTTPKSKSKNPKLARLMELKDTYDEQLANTMTYISSLFNGIVFHRYRDTMPELRVLTVEILGKWIGALREDFLVDNYLKYLGWMLNDKSAKVRHAVADALQDLYEHEENAEKLELFTSRFLRRYLEMCDDVDDGVVLSIVELIAKIDRLNLLDDQSDLSVVERLVFYAGDLNIRRAAAEFVCLQYDAFGVSDQDMTEKQLVTQAVALIEFAEECMGGDIESVDLLVSAFWQNEDCQVLQDWRLLTMLLGSDTHEPALSNEQQTILIRLLTGVIKQIVTTENGAGTQQAKKRRKKDDAEPMTIFFCREIPPLMLRFQSEPEKLCLLLQLVSTLNWNATIMNQHKKHVEDLLARLKHAYLTHSDERFIQELSCCIDHMMESTNTALTREVSVLETEIFRECLDQCQTMLEQEKAAKTKDNEFALQAWLTRLHFLSGFINIKEEGSGRIDLAGLLSSFVRGRCTMDLSKVQLSSSCVRHAIQILFKDFLWSSEPMFAAMKESPQSEVPSDIVDEIVIKRENIESLLLQLLSIHLSERVTHRTPKDQVLEVPELELTNEQVEYVNVLQKTAFLVLGDLRCLCIQRFEEAIELFNILAFRPHKNLVMLSQSYYERTMENIETKDEDKENLLAALASTSMCNPENKTQGAAVLQQMTSPSFQPIIKAFGKRMCSFSVVKYLEIQMMTLQQTFEESPDLAINLAKVLNQTLGVKFPASLRGSFLKFMAEGLRYSFEAPANGSFLLAMKPYLHRLDKIGTKSLRGHFEKLRSSVDGQDFDDAVSEFEAFFNRGQQAPHQEPTDNSQRSQIGTTADEERSDFKEINEGPARRSRNLSDDEDEPSTAPGTPPPENFVRPSTSKKQGRVKRNSVLGDDDDYNSGSPSKTERRYSRSTRSTRASQESDKDDELAKPSSSEASKEHLSRLAERETDEADANDEVQNDESSPKPKSIEGSDDEVVGFRTKRRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XU59</accession>
    <name>A0A6G0XU59_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_001602</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XU59"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003566"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047134">
        <property type="term" value="F:protein-disulfide reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045108">
        <property type="entry name" value="TXNDC17-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010357">
        <property type="entry name" value="TXNDC17_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12452">
        <property type="entry name" value="42-9-9 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12452:SF0">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06110">
        <property type="entry name" value="TXD17-like_Trx"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="93"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="228"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0743962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="340" mass="38048" checksum="0A58D9FEA913A505" modified="2020-08-12" version="1">MLPRSSTASASSSASSALARCSTLQWMQWSIAFFVVSSVVFLSQISTKLRTQEAVSMIRHNHLRPAPLEEPHQLVRDTVAGFDAAKLYLAKADFKDEQPDFIVIMSGTRPNGEYWCRDCQVAKEPLNQAFTAKSRHHLLVTVGSHAEWVKSSNPFRTDPLFHIDEIPALLRNNGNLNTSVILTGGAFLSDTDMLDAILGPTQMQPAVEQVDTFDGMMSVLEQHQSSGTTSDLFLYFISGSTPSGELWCPFCAKADTPVMLYYEKFASKDAKLLRVVTAATYEDWHRDDNRFRTQTVIEISGLPMLVRVKPHQDQIAFEEFTTFFEETALLKAFFQGEAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XUW2</accession>
    <name>A0A6G0XUW2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_000814</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XUW2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018838"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0744326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="414" mass="45458" checksum="75E55BB7CBF08942" modified="2020-08-12" version="1">MSSTIVSHGKRVTKASVPSYKMRDASAPIAEVAESKPGPPAAAITLTAESVQEQIRLLLSGTPDEVKRAIGTIYSASHDQVSMELFITNSGIPPLLRQACRHQKLSESSRALRLLFQLFLNHHQIDIADKIIAVTRVKSLPLEQKNALRLLLAFVYVMPLPDIHPAKSDIVDAIKETFKQLLRHLWYGSSLDVALSLDCLSFISVTPVYLEPLMSLMDTPLPKPVGGTQLSRASTYLNVSHEPSSLSPQTSPRRSSWLNIRRQSAKLLESGLGMLKDMLAVRTPTVYNGVNGLAHIATVGTLTEREAVTMIVLEWGKHDRVDDVQSVCASFCKALVSKLGGTDVADIHKIQAISCIEQLVQRDGMRLHLLEAGLSPELYLLVQLGTEGPRHHAERVLAALLEKPDVAEFFKPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XV86</accession>
    <name>A0A6G0XV86_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_001052</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XV86"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009462"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05162">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="996"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="565"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="352"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="565"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="634"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0744583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1125" mass="124610" checksum="1FE8C1708DCBFC73" modified="2020-08-12" version="1">MTPCGSAALSQRASDVIQTSSVAWAMDVKSQVWWPVYICKTVERNERENHTEETYLVYQFGIHTFYSVPLAHVKPWCCDERYLFTHAQAILAQLPQALVVFASALSEANEKYQSVGNKHPWLKSELSEIRPICATVIIERSQKNHPVNGDIVEFVEERNTEDFPILHDTGTRLLDVRLRRAPPLSPVTMPKSLFKRGFKHRRRASLDAIDERVKQMDFLLETQKRKLPKNGFNEAKSLKKNWKLWAECGQSQGESVNISHALPTVILQSDVSGKAVFEGDQRFVSETERQFGATGNLLSHSTIDKPCGAASYLPISQNIPRSDVEHNVVKSIETANEKDARLTTLHQATGDSTSTPTNGMSTTTAPVATPQLTNQDAESVAIECTEQADAHVKNTYNVSSTMPSIVRHLHQPNNSFITPPNGSVATTSNIDDGTSGSSELKSLTDDSASKFLYEPGKDTFLPLLNLARWVCDYSHLQLLVLSMPPLLRPPVVKSLLHEFTRVVKSNTRPIFLTFRRSKPPSRAKNLQPSIVQGSVFAKPLKIVENRIKMDAIENTANTCVGKSASATKTKIGRSQSPSISDINESNMDDAQMDDLPKTKHLPTTSLRVDSRSGAELNQIDGATETEPSDDESSNHISSPQRSPSDLSTQTETGSPSDTESESEDRINSVDPVEPAEEQECLSQTIVKEAKILDDTEDSDNKGDNHAMIVYQFGRHVFHRRHVQTKVREWRGPDHVRMAHGQPRIASKRTSAIMWIFSEAIKEAEDFMSTLHEVNHASPLVNLHIPHLKRIANAKATVKDCWCRLCAAQTIDRCTAFTHSLTKLYGPLKQLAIAVVEGDESGLSVPFSGLHHAMVICAFAIVLSDALAEHSTNLMDLMHHCGHALIWAIDGVAVPDLQNDVMSACQSFVENHLIPAASHSNVVKTIAAFFTQTNYLAEKPWYPDMQRVATGLDHSLVSKLHSISPTLVEEMRLLDELRHRLEDRMAEYTVDWPGLRAVTYDVAFQAGPLGITFFEEEDSIRVKALDPQGQGQASNQVSVGDFVVAINGLSTKLIGANGVLAAAVAAPVIITFERMTCLAHPQGRKDPRLNKANVAVRDVQVSVRGRREDENESPLEPLAFCFHVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XVY3</accession>
    <name>A0A6G0XVY3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PWWP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_001019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XVY3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009240"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="304"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0744545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="455" mass="52001" checksum="957EF9F7FC1457FC" modified="2020-08-12" version="1">MEMAHSVLCLDSAIGGDNLDSMSSSNNEDGKYNRVAWGSTNRVLWWPVYLCDPATIRDELHILQKSHKNAYKSRHDPSYPIVYCLGRYIFEDKKMHIKPWHCLEHDSFVEKGLNSASDKTEREWARALREAQRIRVRGVVPYLLPPDLNKKLPAPPKSCNAPPGSIVWLYQQKNRPWVPCYIFDPMRLRHLKGNVHSSDHLATAQRNPEKYYFVYAFGEHTVSLYLKSTPAVKYWGCPEHDGLIEGLPKIPGYKSKLDKAVQEVVAFAALGHDWRMLTLPGYGFVEPNVALGLPLVSRATPVASSQTSDQSITQTPAKEKKEKKESKKRPISPPPAVEKLSKQQKKELRERLYLEKEAATQALIMTNPDYPNGVAWANRVSTMWTPVYICDLAKWLIPQGKRLEPIQVYFFGTHEIAWYTGQLKPWKCPNRLELVNSRKSFVGDEFDNSLLEAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XWA2</accession>
    <name>A0A6G0XWA2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_001226</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XWA2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002978"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000289">
        <property type="entry name" value="ABC transporter G family member 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="73"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0744772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="377" mass="41076" checksum="EF3B46544F37767A" modified="2020-08-12" version="1">MCGSYVIFSFLSYLVLEYTRHDPDSHASSANEDESAQTENEAYLEIPATLSSKDLIGKKITNEVRSAVAPVTLAFQKLSYSVPNPKKGEPELKLLTEVSGFALPGTITALMGSTGAGKTTLMDVIAGRKTAGKITGDILLNGYPATDLALQRCTGYCEQMDVHSESATFREALTFSAILRQPSEVSREAKLAFVEECLNMLELTSLRDTIVRGSSVEQMKRLTIGVELATAPSVLFLDEPTSGLDARSAKLVMSGIRKIATTGRTVVCTIHQPSAEVFEMFDSLLLLKRGGQAVYFGELGQNSSNLINYFTRIPDSPPLLEDANPATWMLECIGAGVEVKNRTTNVDFVQIFEESPEYKDLKAGLDKYAHPSQTFQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XWF6</accession>
    <name>A0A6G0XWF6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="5">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_000615</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="5"/>
    <dbReference type="EMBL" id="VJMJ01000003">
        <property type="protein sequence ID" value="KAF0745038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XWF6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001738"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07130">
        <property type="entry name" value="ALDH_F7_AASADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000018">
        <property type="entry name" value="Alpha-aminoadipic semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044638">
        <property type="entry name" value="ALDH7A1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43521">
        <property type="entry name" value="ALPHA-AMINOADIPIC SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43521:SF1">
        <property type="entry name" value="ALPHA-AMINOADIPIC SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="8">
        <location>
            <begin position="53"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0745038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="527" mass="56582" checksum="9FE9FF7073CEC477" modified="2020-08-12" version="1">MFARRTTNALRLVGCRYQSGLTFSKYPFLSELGLKETNDGVFDGSWFGNGPVFTSVNPATNEPIATIRTGTKDDYERVVKSMDAAKKEWADVPAPRRGEIVRQIGDALRAKQTALGNLIALEMGKIAVEGVGEVQEAVDICDFAVGLSRCLNGTIIPSERPGHFMMERYNPLKGHVGIITAFNFPCAVMFWNGALSLVAGNTQLWKPSDSLCLTAIACNKVISDVLTANGYNPAIASVICGSGPEVGEPMIRDKRMELISFTGSTHVGRHVNQVVAGRFGKTILELGGNNAMIIDADADLDMALRATLFSAVGTAGQRCTTLRRIYLHEGIYDSFLPKLLTAYDQIKIGDPLDPTTLCGPLHNKAAVDKYAAGIETIKSQNGKILRGGKVLPGPGNFVEPTLVEIDHDAPIVQTEIFAPITYVMKFSDLDEAIEKNNDVPQGLSSSLFTQNQAAIFKWTGPAGSDCGIVNVNIGPSGAEIGGAFGGEKETGGGRESGSDAWKQYMRRSTCTINHSKNLPLAQGINFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XWJ1</accession>
    <name>A0A6G0XWJ1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_001210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XWJ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002222"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
        <property type="entry name" value="FYVE_like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43102:SF2">
        <property type="entry name" value="GAF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43102">
        <property type="entry name" value="SLR1143 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="263"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0744755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="443" mass="49013" checksum="B73A8F7236A0CEBB" modified="2020-08-12" version="1">MECAQAAYDAIVESQGNMTDKPDSKKRRLAKACATCFRTFDAFHWKYSCHTCTRVVCRKCTVKVAWSKRVCWKCVVGVPSVMPSYMRDECPVMDKTEGSTCFLPPPESTATPTTTHFSSEYTYTDMLLPSCRSRGESSVDSFLEDGGLRVSAKLSDDDHDLSRYSTKLSSRAAESQSLDFDWVHPFPKAPRPANEASRLDCVRRLDFETHISFLQKDPFFANQVKNAMDIADATIGSIHLVAESVVFNLGSTGYSSVFEVDEVALREEATCAYGLLQTTPLVVLDTSNDVRFRAHPLAVEHNASSYIVIPILVSGVNLHKECIGTIDLAHHTPLSGPLSPLQIKALQAIANAVGIYVERRCADFNHVQESNRGRRQTAPIGTIEEENVTDSMRSSAAKKRETLNSIWERAMQTSLYMRATISGNGPTTSSRGYIPTMASSRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XXI0</accession>
    <name>A0A6G0XXI0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small-subunit processome Utp12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_000342</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat WDR3/UTP12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XXI0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011499"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000157">
        <property type="entry name" value="WD repeat domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051570">
        <property type="entry name" value="TBC1_cilium_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN 3 WDR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25173">
        <property type="entry name" value="Beta-prop_WDR3_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25172">
        <property type="entry name" value="Beta-prop_WDR3_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="101"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="143"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="185"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="376"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="459"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="563"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="605"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="6">
        <location>
            <begin position="778"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="275"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="277"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0745314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="901" mass="99483" checksum="5D5B6F838B2992DA" modified="2020-08-12" version="1">MKSYLRYTAESSFGVICSPNARCIYDLTGQLAICGALKNVLVWNIRTGAQVRVLRGESENDTAGQVTALCLSPDGAYVATGYSTGMVRIFKLSNGNVEVTLDGHKNSVESLAYGENGALLASGSRDTDVIVWDVVSQSGLFRLRGHKDAVTALSFLDNRRALVSTSKDTLMKVWDLDTQHCVQTCVGHRNEIWSLDTHAKTNRLLTGTSDNLLRVWDIQEGTSAEETLRLLGTIPRQANDRAMQVQYNPQGTLIGCQGAGKTLELFRVRSADEQKKKAQRRLKRAREKARKKDGAVPEAPEDDKDNENPIADEVEALCVVRCSAKIRSFAFSPDTARDGTTSLLISLHNNTIESYTIVPHAETPDGRYSKVHTLALPGHRSDVRAVSLSSDDQLILSVSSGDVKVWNANSRQCVRTFTDFSLALSAVFVPGNMHVLVGTKGGALHLFELASGECIWSKEDAHGGAIWSIDVRPDGKAVATGGADHLVNFWEFEMTAFQDEAGNSSSALKLGLVHTRMLKMSDDVLCVKYSHARDPKKLLVAVALLDCTVKVFYDDSLKFFLSLYGHKLPVMSMDIASDDTLLVTASADKNVKLWGLDFGDCHKSIFAHDDAIMGIAFVPRTHYFFTASKDKSIAYWDGDHFERILKIDQQHFGEVWAVAVSSDGSFVVSTSQDRSLVKYLRGDDQVFVEEEKEKEMETMFENDLVPTNVAPPTLGGTNVQPTQESATAAKRTVQTVKSGERLMEAIDVADRELKQSKESSAPSSTNFMLLGYTPLKFVLRSVREIRANEMEEALLVLPFEYVKKLLSYLLQLIAAEMEVEICCNCVLYLLRLHHHQIVGTTGLLGELDSMWGSLRNQLVASKNRIGFNLAGMKFIQRQISQHKTGYVEELGGQPASKKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XXJ5</accession>
    <name>A0A6G0XXJ5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DAGKc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_000313</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XXJ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014263"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001727">
        <property type="term" value="F:lipid kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045540">
        <property type="entry name" value="YegS/DAGK_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF31">
        <property type="entry name" value="ACYLGLYCEROL KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19279">
        <property type="entry name" value="YegS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="5">
        <location>
            <begin position="128"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0745282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="474" mass="51924" checksum="B89C14C198B83BD4" modified="2020-08-12" version="1">MEGTLTCSHFTLSHRPAVLTALLEGLKIEVPTKPNLGVLLRWEDVLGANNTRSLQVLAVEDGIPLVIHTLVKARNGKRKVGSIVLEVSQSVHQNNIDDWIKIITYFADPLRPALTELPTLDTITENQPKKRNFMVLINPASGRGQGEKLFKKVEPFFVNANIDVTKVLTQRAGHATEVATTLDRSKYDAVVTVGGDGICYEFIQGLMKRLDWANAIQTPLSVLPAGGGNGLAKSVADNAGEVLTFENSAYLAVKGRPKPLDLATVRNKTSVSYIFLSLSWAFIAEMDKDSEKYRFMGAQRFTVAAVAKIMSGKHWSGTFSYIEAREDEAVPSYWESEAASADATAPQLSLLSAAVDSPKPESWKSIQGDFSMFWALNVAWPAADANFAPTAKLDDGHFHIVYIPGKATKGEFFNVLTSMDTGSHIEKPCVRVVKTRAFELQVPETDLIMVDGEAYQGGLCQVEVHRGLMRILST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XXT2</accession>
    <name>A0A6G0XXT2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_000306</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XXT2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018443"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06786">
        <property type="entry name" value="cpPDZ1_ScNma111-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025926">
        <property type="entry name" value="PDZ-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46366:SF1">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN C1685.05"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46366">
        <property type="entry name" value="PRO-APOPTOTIC SERINE PROTEASE NMA111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12812">
        <property type="entry name" value="PDZ_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13365">
        <property type="entry name" value="Trypsin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="261"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="737"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="835"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0745275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="956" mass="105395" checksum="8B03F2EE76403EA6" modified="2020-08-12" version="1">MQDKDEEFEEENINVMTGSPTRSTSPEGGRWLASLQEAIPAIVIIRLMSVRAFDGDGASFSVATGFVVDKKRGLILTNRHVVTPGPVVADAIFVNKEEVDLVPIYRDPVHDFGFYRFDPARVKFLKLHEIPIDPSGAKVGVEIRVVGNDAGEKLSILPGILAKLDREAPNYGSSGYNDFNTFYYAAASSTSGGSSGSPVLNIEGAAIALNAGGAKKAASSYYLPLDRAVRALRLIQNGADIPRGTWQTIFRHAAYDEVRKLGLTANVESEFRSRFPEETGLLTVDQVLPNGPGFGLLEAGDVLVKIQGRYETTFLALEETLDSSVGKSIEVEIQRGGIPITVNIPVQNLHDITPSRFLEVGGCIIHSLSYQQARNASLAVGAVYLAQVGHMLMKAHIAQPCIIVSLDGTPTNTLDEFIHTIRHMPNGHRTVLRYFLTRDRHRIRSAVLSIDRQWFPMQLYERNDTDGLWHCREYEPPSVQAVPTIPSFPAAPLRVPGTGSEIDKNMLTRLLSSLVMVAFDIPYMIDGISSSSYNGVGIVIDAANGLVLVDQNTVPIALGDVLVTVAASIEVPARIRFVHPIHNFAIIQYDPKLLGETRLESIRLSNEELHVGGQADFVGLTSTWTVVAMKSLVTKIDRLVLRDFQPPRYKASNVEVLHFDRITKSVGGIFVDSHGLVTALWLSFSYQDESGRREVFRGVDVDVVREVVEAFQSGQSPRSVTVLPVQLYTYPLSKARAGLGLSPHWIRMLEQCYDDKRQVLAIKRCAAGTHAFTQLQSGDLLLSIDGVVVAKDFGVERECIGKAQVQVVVIRNREELTLTVETCELSGIGTSRVIVWCGLVIQEPHYSVVNLGYLPEEGGGVYCSRWCYGSPAHKYGLRATMWIVQVNDEPTPTLDAFIRVVEGLRNGDSVRMKTISLNTKPKVVTLKTDYHYWPTVELKRIGETGDWAYVHHPNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XXW7</accession>
    <name>A0A6G0XXW7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycosyltransferase family 28 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_000343</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XXW7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004885"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016906">
        <property type="term" value="F:sterol 3-beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000163">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000009">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="EryCIII-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF13">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="EryCIII-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase family 28 N-terminal" evidence="3">
        <location>
            <begin position="4"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Erythromycin biosynthesis protein CIII-like C-terminal" evidence="4">
        <location>
            <begin position="293"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase family 28 N-terminal" evidence="3">
        <location>
            <begin position="705"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="630"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="639"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0745315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1261" mass="140113" checksum="FD981CB485E5FE1C" modified="2020-08-12" version="1">MQVCIMIVGTHGDVAPFVGIGKRLQKDGHRVRLATHATYRSFVTKNGLEFYPLGGDPKELSAYMVKTSGHIVSFNYEILTKDTPRNLRMIDEILRSTWPAVSAPDPEGDPLLPPFRAQAIISNPVTYGHIHVAEKLGVPLHIMFPQPWVPTQEFPHPLSNLPYKGKREKRNSMSYHIVDALMWAGTEGLVNSFRQEVLGLTKIRKGDGGRSMLLDWKIPHSFMWSEHLVPCPPDWDLQLYDVIGTVTESVDTTSSYTPSDDFAAFLASGPAPIFVGFGSMVIPDPAKTTQTIIDAATEAQVRVVIQSSWSDMSNGGSIEIPDNLFILGNCPHDWLFPRMAAVVHHGGAGTTGAGLLAGKPTFIVPFFGDQPFWGWAVEHVKVGVRPCPLGDLTVKKLRQAFLQLLSPATIANAKAIQAKMQQENGIENAVQSFYRHLPKMNCAFTPEHVATKWLHDDKIQVCDGCAFVLRARTDQPIEDYHPVQYGIMGPLNALEGVSSGAGAFFHELSGAVKDIVAQPARGFKKDGLRGAGVGAIKGFGGLVVRPINGLAQFVTRVAVGAHNAADHGEDQRRVDEPTHWIKEFHVKRTAPMVDVSLSEEERAAVQAAIEDARAHKPLSVIRENTTHLSSLSSASTLRDEEDDDDDDESMPNYLHKTSYGTFMMGSPDANVQSKQRAAFARSYSSRMAVVEDDWEELTVPFSMSIAMLVVGLPSDVEAFVAIAKSLVRDGHRVRLAAARRFETFVKASGVEYVPLEGNPTTSQDRLSTLSHWEGIFHQEKPPNAPWNNDEAFGISAWRAVKSSDFRADLIVAHPDTMLHVHLAERLGVPLHLLSGIPYSPNADMPHPLVEVMAHEDQQSNWFSYLEVHRFVWNHFRHATNKFRVQELHLAPWNAKHAPAWWQWHIPISYYWSSLLLSKREDWGDEVDVVGFIQLDEDDSKYVPQPELAAFVAQHALHRVYISLPAMNQNMLISMTEVLLSSRSDIQVVIGQEDIMGGPMFLSDRLVIVDASISLKWVVEHCQVVIHQARDARLLAEILQQNKPSVAVPVTAIEKQWANHLREMDPDVHFPPVSLESLAGQPEMLADMVAKLVAAVEVDVLSFWSRHVVLETKQAIRRTVSSIYKHLPIEAMQCDIIPSKLARVYDPDLDLKLSYEAAYVANQLDADKVAKYAPVFYSLKDLPQVAVKAGRAPKRESAMDSLLMGSMPPVGPAFAYQESMTSLPIDTSLFWKTHSEEMAFRKRASDGYDKLHTTRAAATSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XYZ1</accession>
    <name>A0A6G0XYZ1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_000162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000001">
        <property type="protein sequence ID" value="KAF0745713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XYZ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015445"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0745713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="269" mass="29112" checksum="2D692F9FAC945048" modified="2020-08-12" version="1">MSHGQNIQIPSLKRNLSGGAATNGSNAPLSINTSSHMNMSAAASLSALASGNGSTERSPLQPPHRIDQHGLSSHPNSAISHSYPSLQHDRYLPGPPQHSVTSTPPTIQRAVTSSSAYNRQPITTRVSTTTVGGLHSHSIPTTGPPRMSGSSTSSSAPQQDWRMYLTIEERQAVRSKIHDAYTSTCKTYEELLHAASAIEEELLHIAAPSRLDYFKSGFEFENRVKLKREQLQGQLATMEKKANKTQTTDTRPKGSPVSGEHAAKKSRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W2A7</accession>
    <name>A0A6G0W2A7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_019259</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000594">
        <property type="protein sequence ID" value="KAF0720916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W2A7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005259"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017733"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF463">
        <property type="entry name" value="REVERSE TRANSCRIPTASE TY1_COPIA-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retroviral polymerase SH3-like" evidence="2">
        <location>
            <begin position="55"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="206"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0720916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="585" mass="66367" checksum="DE0A98EC3F641F7C" modified="2020-08-12" version="1" fragment="single">MLIEGSLPKFLWAAALDYAAWLVNILPSTPNDGQSPYFRVFNTHPPLCYIKTFGCTAFVHIQQEARSSKLDPSSLKAMFVGLPSNRKGYTLMHLLSHQLIYSRDVSFFETEFPAINSIEAAAEYRLRARNDPNFIPTLQPNAPLPPLHAALDRPNTIIIDQPTSNPACLAAHSSSMEAAFPFVRPPTNPQQFTLLHHFPNFSEVPPDYVCRLKKSLYGLKQSPHLWYWTFVEVMTSKGFTRLHKDRCVFLHTSDDGFTIVSLYVDDLLIIAPTTSLVSSMKLSLFDCFQMKDLGEARDILGWQIERNRSARTIFLHQTRYCETVVTRFDMASSHPVHTPFECTTKLSKSQCASTPDDIAFMASKPYRSLVGSLMYLAMGTRPDLAFPLQQLSQFLENPGPAHWRAAKRVLRYINGTRSRGLLLGGSDFIHKPFLSAYVDADYANCKDTRRCVSGYVLLLLGSPISWLAKKQNIVTLSTTEAEFVALVLCIQECLYIQQLASELKQSSDQPVIIYEDNQSTIHVAQNSEHHGRSKHIDVRYMFVRDLVEAKHFEFRYCNTKNQLADFFTKAHPEPAFKSFCKALRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W3A7</accession>
    <name>A0A6G0W3A7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RxLR effector protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_019072</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000384">
        <property type="protein sequence ID" value="KAF0721578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W3A7"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026228859" description="RxLR effector protein" evidence="2">
        <location>
            <begin position="31"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0721578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="33135" checksum="92F119842424D98F" modified="2020-08-12" version="1">MKGTFPNSLRRATMKVFAFLAFVAAAMVAAEEANQAAAAAAAVAEIASNEFNSVAVAPEEGERALAEEAVAKSDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDRRLEVAEDDVAEADEAAQADAAKNDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDRRLADGNDENDADESAADEGAADESNDEGNDETASDENDSDESAADENNSDESAADENDEGDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W5C7</accession>
    <name>A0A6G0W5C7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_018780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000355">
        <property type="protein sequence ID" value="KAF0721958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W5C7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015036"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF57">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="1">
        <location>
            <begin position="211"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0721958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="383" mass="43835" checksum="B916E5C5E9912D35" modified="2020-08-12" version="1">MNATKTRRARPTIAEKLRAVTMAESTSVREAARITGWNESSLREWIRDIDKLKNFKGSKARKKNTGNCGAKPIIPDSYELAVYVRDIRREEKAVTTAHLINYLRVNHNTWLQDYVTTRSSGYKSLLRLLQNFAHRHDFTRQRICRQKKTQIDLEETRRAFATEFSEKHGDLPANCLYNADETGIYFDMCPKTIWAVRGGGSYVSSGDKHSSRMTALLTVRADGLKLSIVFIIRGVDGGSIEKNEFDSYPAGHFYYMQQKAWMNGNVWKRYLRDVLADNIEDPSVLLVDNFDCHVSNESERIIGEELGSVLYPLPPNSTSHCQPLDASIMGPFKQHLQDLWIMSDVTATTAKEKRIVMIERTIRAWSMISEDEVRASFKKALKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W5D1</accession>
    <name>A0A6G0W5D1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_018556</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000340">
        <property type="protein sequence ID" value="KAF0722264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W5D1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021553"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="31"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0722264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="333" mass="37128" checksum="2F4B87E94557325C" modified="2020-08-12" version="1">MGNILCPTREDEDAKPLMTKPPPKPKFASQYHLGDKLGEGAFSVVRKGTNIASGKEYAVKCLSLRHISPQEMENIEREVAILKELKHPNVITCHGFFLEDHAGYIVTDLMQGGDLFDRIVEKTLYTEREAKDVVHAIVDAVAYCHAKHIVHRDLKPENILLSSHEDGALIKIADFGLAKDDEYLTTMCGSPAYVAPEVLSGGDDKGSYDKEVDIWSIGVITYALLCGYLPFYDENPAVMFKKIKRGVFKFDSPHWDHISTCAKSFVKMALEVNPTKRATAEQLLHHSWMETANTATIPLNVSGLRKLHKHTLKSAAKAVQAAVHAQRLSQHRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W5L2</accession>
    <name>A0A6G0W5L2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_018541</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000339">
        <property type="protein sequence ID" value="KAF0722325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W5L2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002099"/>
    <dbReference type="OrthoDB" id="76153at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37473">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37473:SF1">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="125"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="167"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="256"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0722325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="376" mass="43594" checksum="BC23F2A741DA397C" modified="2020-08-12" version="1">MPRLEPPVFVKKKKANNARFLHSNTSMPSLDAAAGNDKTKSQSGSCTQDIGQHIFHAIDASITPPGDRGVDLDMFRKDCSKLTDAKATMLLDMLSTVRATHLPREVVQNAWLRLVEEERQDLLELSTASTSPRSPRDDRGAHSTTPTSVRPSTSGATTKLSTAKSKRKQAEYDAKLLANRLALLQQEEIKAWRKIEQTREKAQQILEHREEIIKKQQDKYMLLHEKEETIRSATKKHKLAAKTSVIRKRQAAISVISKKYQEVEQVKIERRRLKQEKEKQAVDEVMRAKERRERVRKQEEEMRKKRMKEKVTAEKQIVERYRKSVQEEELQLREQQRRVAELERAEMELIQRLQSTQLLQRQAYDELEKALVGTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W670</accession>
    <name>A0A6G0W670_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_018322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000330">
        <property type="protein sequence ID" value="KAF0722589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W670"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002175"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="380"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0722589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="412" mass="46093" checksum="9B82C35B36707ADB" modified="2020-08-12" version="1">MTTTMTADKTSSRAKGLNPFKAWTVSALQRFQSGGSGSLKTTTSREKSRHVRERCMALGQTCDPQCIVDNMRLQGGVHHTQLLYVVFNGRPLHLCCYEDVVCTWFRAQPGREFQEIAGAATTDWYLPTAEDIGALLLVHVDLGSVVGCVEFGPVVEDPSVRSQVENALDASTAFYTNVRLVPSDNNEGCSCSDYIDETWSLLLDDKRIRLACESALVPPFEALYSSVVTMRLCPLRSNVLTLDFGGEDGAVDLQVDWHDRRDVVYLVFQALSRLALQSSAHVAALSTGQSPMLTCRTLPPQHDQQHEPLAPCYELPWTMRRRRRVPTYLPKEENGQSVLADEDDDDEPLVNSMLLHDVDALLVLSRQLDHHKPRPVQAPADEMQSALEAMKAERMVLERQLDQLRRERVALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W6M7</accession>
    <name>A0A6G0W6M7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Maltose/galactoside acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_018144</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000323">
        <property type="protein sequence ID" value="KAF0722792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W6M7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013994"/>
    <dbReference type="OrthoDB" id="25818at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03357">
        <property type="entry name" value="LbH_MAT_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000008">
        <property type="entry name" value="Maltose O-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051159">
        <property type="entry name" value="Hexapeptide_acetyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024688">
        <property type="entry name" value="Mac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416:SF23">
        <property type="entry name" value="ACETYLTRANSFERASE C18B11.09C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416">
        <property type="entry name" value="SIALIC ACID SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12464">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01266">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Maltose/galactoside acetyltransferase" evidence="3">
        <location>
            <begin position="5"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0722792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="187" mass="20497" checksum="08B9B3F31E157BF8" modified="2020-08-12" version="1">MDSEKAKMLRGELYSSVDPELIRERQEARKLVKKYNNLDGAETPEAQEILSQLLGAKGKDCFIEMPFRCDYGSNIRLGDNVYMNFNCVLLDVCEINIGNRVLLAPNVQLYTATHPLGPNARSSGYEFGKPITIEDDVWLGGNVTVVPGVTIGRGAVIGAGSVVTKDVPPMCVYAGNPAKFIKKIEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W708</accession>
    <name>A0A6G0W708_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DnaJ homologue subfamily C GRV2/DNAJC13 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_018107</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000320">
        <property type="protein sequence ID" value="KAF0722876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010652"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000641">
        <property type="term" value="P:regulation of early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044978">
        <property type="entry name" value="GRV2/DNAJC13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045802">
        <property type="entry name" value="GRV2/DNAJC13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36983">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36983:SF2">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19432">
        <property type="entry name" value="RME-8_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DnaJ homologue subfamily C GRV2/DNAJC13 N-terminal" evidence="2">
        <location>
            <begin position="165"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="DnaJ homologue subfamily C GRV2/DNAJC13 N-terminal" evidence="2">
        <location>
            <begin position="532"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0722876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="2191" mass="247149" checksum="FAF660839DBD8C3A" modified="2020-08-12" version="1">MASTSERVDVEHEETNGEEHVEQAPVTATSHLDSEEEYEEETDEDEDDENGHSLPPPPPDTTEDAAAVAPSTLLLRQRSHLPSEADLEENLEEYLTYGGAHPDLVKLHTGYVPWTDSVLKEYEANKDKGLIDTDVPANRLSGVIYAQRFWVTLAGWGLGFGSKPKLLVLSPSNLFALDPSNEQTTDTWAYSDISEVISTDVTSFTIVTKTNQRSTYICKDKETRNQFLSSYYQLYYRDRAEDKDHAATLFQTPTYIMKKRSKTKGTLVNPVDTPVLLEVRRASLDRLDLKTKKPISSIPLTNILKVQKLQNEPHGLVLYFQQDKSNITAQRFTTEEREAFIGVVINNLRTIVKDPLLVQEVPDASEYESLVHPSDPVSVLFEMSVLRRSKTTREKLVHLALTRTDILERDPVTHRTWARFSISDVFNVVISPEETEKFSIELKNGRTRRYTSVQAAVATRSIHVGLGLEQVNESRLKELQAAVMDPTFTPHPSFSSAGSTTLLSATASRNVWLSNLVEVFHKNKKHLNWSTEETPLGCKVGGWAADCNSEWEEMLLKKLHVTWKTTHDNQPHLDQMFRFLEQFNKNLPIGSLTSRNIVKPLACLLKVVEQMREYISLKIKDPSSNSHAAIPSPALQVALLLAIQRLLHTTAGFQEVIRRDYRKIILVMIEFLYSPVLEVGFAAAQVINCMVINYSVDKNITRLELANRKAVFHTEKRASMFVNRIFDPRAQTSNVYSIDSVPNPLMNRVLSSTLVGLDYLVLGSILSTLEVCLVSGKRSTPEKVHRDLLQSMRIDDFAHQHTLFSLNRSLSFSVTKNSSIMVKVHVLEQPSELVELIQDFARIQGALIWQLYLSLGGHDQSQRRISSQLVALLTHENPRSSNLIRNIFPHALLGDIPPEKCSYDEFGRRLPSMSSVVPLGPAPAPLSNVADLNAVRLSVDKITDKIDATAVEDVNFNEKVHAGVTSRAQVVATSKCVVLLPDFFDKLRAVIVQKDLKWDSNNLAELQQRLIDELSLFDLNRLTYYFFLLSNPTERQETALDLSMEGVRRDEDILANQFPPMLSGQEFFLPAVDPSEDEEQGNHRDSHVSDALATAETPKPFWFLSWNANEFTVEFKCLENEVRVGAYYLKALFNSQGDLIEDIADPEPFMNLLYFRVLATPHEAVRHLCLKTMTSLYNKYANDIRSLVFLNHFIRVTMDPSAFSLTLRGHVMLFVERVLSNAVNVTRFLHEPRNLDLVLALLKEVKPLENDAEATSITQTCLLVLMKLVHCQSTEQEELTKTEYFVGDEVTTTNAVGPVSYIKRALSDHLKFLVSLLDHPNRNVFRRCIHLFTLLVQNNESMVPSLHTTGLFYYLFRNTHTESDMYIVGNFLTNVHLRQRPVHLSPEELTKLLTRTTGDDSFTQRCMKSWLIKILPVSLVAQLVRHGSQKFASVYFGTSNDPETLWNDDMRNEMLSQVNEFITNHLVDGEFTLAVSEEDTSTPLITYPQEVYALQCYQYYLHNLLDETQFPNWPINDPPAFLRALVEAVRVWVYPTNHSKITTKDIVMVFNSISLLFRRFWTSLEPRLHEYLNFSLLLLALKKCNDMATPQWDVFLSALEVITTSCQSSAIINTMKDTTVVSGLRVMYDALVLAHAHRENDLTPTRFLLESFKRIVYQPLGRDGLSSSPSLSILPYLQPYLELSTPSQDLTALALQILSGMALGSTKSDELLDAMAKRGVVWYLAPIICNQNGTQSTRTLAAEALKGILQPENAPAVTARGRMQRTIDQIFTRPLIDLLLSQTNPEMFLNVVSHDVKKPHMMWTASMRQQLFTLAEEAHASTKEFELPQGFMYEAQQLELRVADIYVNFYNNDPEPGITALISSGLADERSGRGTYVTDQAEIRKRVMANLLSALSHDIAGVRARPEILESVLNERMLPVVTAVRHMLQFTPEMDIQLVDVDGIVTLFAGLDHDETKIRFSTEKAPFFQLRVMECLHIAMFSPKCIEKIAEKITHYVKSMFAAVYNHLPKRKESDEGQLGRVALQFLGNLCLVPTCIDKLVSGMDAAALAKTLPLMSAGNNHQDVELLLNIHTTALKRHTNLSIGFAKSAAMTQMVSALLNLLSAPDAIAGNTKAPIARFLSVLSIIPGNLVSTSLRDSKVWKDYNATHSYASDRAQDASADVKKWLVLPNAPALLKFKYANPQKIGMLVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W754</accession>
    <name>A0A6G0W754_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator of RNA polymerase II transcription subunit 20</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Mediator complex subunit 20</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">MED20</name>
        <name evidence="5" type="ORF">Ae201684_018051</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the Mediator complex subunit 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000319">
        <property type="protein sequence ID" value="KAF0722976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W754"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010217"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013921">
        <property type="entry name" value="Mediator_Med20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12465:SF0">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12465">
        <property type="entry name" value="UBIQUITIN SPECIFIC PROTEASE HOMOLOG 49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08612">
        <property type="entry name" value="Med20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0722976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="295" mass="32370" checksum="5D53A1A6877BEEAE" modified="2020-08-12" version="1">MKFPPISLAPNLAASHLNEGNPGTDFATRPMMVFPDNWNWTKMTGMTRVFIYTDSNIPVRYQTLMKKMEEMGARKVGRSVVHCRMLSRKVLVDGYANQRMYLLRMSQSDDLIYAVLGNERTDASLGIKLEKSLPSSENGLDGPLDECCLLECGLDGSNILQQVEIYVPKSDGKFEGMQFVFGDFIVSICTFVCRASTPTGLILEVQYAPCSVIGDSHQDKLLDEFMAILAETPPTTASSSSAAAAAAAAAAEVVSPVKKPIANILGLFHKLKLGEEYSLKHTAIQYVAAFNILRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W9R9</accession>
    <name>A0A6G0W9R9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_017569</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000301">
        <property type="protein sequence ID" value="KAF0723602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W9R9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006359"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0723602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="205" mass="22036" checksum="B45D206A52660A1E" modified="2020-08-12" version="1">MTLHSNEAAYSQDMSPDSPEQSKSQAKIAKVNRINCIALVVFLAAAVATLALVGALAFPVEEFEESPPSYSATACDACGLLNRTKTEYIPGCDGPEPCCPTTLFPTSPVLSACPHIPSCCCPNSVKRRSQLYNLKCRTTSNECKCAYVNTAGDNFNLEKLAKALVIGGVAGVVLVVSYIWCFIWQCYVGKMKREIQGPLGNQPMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WA28</accession>
    <name>A0A6G0WA28_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RxLR effector protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_017188</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000285">
        <property type="protein sequence ID" value="KAF0724080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WA28"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026119121" description="RxLR effector protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0724080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="30848" checksum="0E0292A286FCE4BB" modified="2020-08-12" version="1">MKTSFLAFFAIIAASAVASVEVASGASPVMIAEERNLEVAAFEAAEADQAAEARKSDDDDDDDDDDDDDDDDDDDDDDDDVDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDRRLAVAEAEASESEAAVEAKNDDDDDDDDDDDDDDDDDDDDDRRLAVAEAEATEAEAAVEAKNDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDRRLEESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WB57</accession>
    <name>A0A6G0WB57_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ae201684_016688</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-5/BimC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000266">
        <property type="protein sequence ID" value="KAF0724622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WB57"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010517"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00106">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000019">
        <property type="entry name" value="Kinesin-like protein KIN-5D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF15">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 10 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="14">
        <location>
            <begin position="6"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="423"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="592"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="719"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="396"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="461"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="599"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="609"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="622"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="102"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF0724622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="758" mass="83695" checksum="B5B4BCBCBAE228F5" modified="2020-08-12" version="1">MAEPECVRVVVRVRPTNERERRLQGTESNVVSIRPPPAAAAAASGDLPTRLQITSKAHEVDASYNYDAIFGSDASQHDVYRYVQSSVEQVVQGFNCTIFAYGQTGTGKTHTMMGPDSSLRHGDMSQWGIIPRAVDGLFQELKAVGSCGAGAFVHCSYMQIYNNQVYDLLQASMKDQPPLQVREMIKGHAKHIYVSGISEFRVGSAQEVLDLLHLGSKNRTIRATECNEKSSRSHALLQLSMEVESRGTERTTIIRRAKLNLVDLAGSEKWDTDVAMTTDRTRELRNINASLSALGNVIAALTDKKRTHIPYRDSKLTRLLQDSLGGNTRTIVIATISPSDAAVEETISTLQFAERAKQISLNVQVNEVVDDAVLLARAQREIQKLKLQLSVEQPNVAAMTQRIQALERQVEALTAENRQLKAQLAATPPEVPRTAPAASTLTDDSRVETPPTSRSKRLTPALQSNTNQDAGDNAIDWEQHTRPYLQQLEGIQKERRDLEAQLEQLKFAHVPEDDDVCPMCHHVIDHHTDAELDRCIELEAQVNGKRQESLLPAAPKAFASTAALPSIKPTITKSILEPQAFSVDPIGGSGGAAVAARGNLSSRGSSKSNPPPSLAPMAPPKPKPKRSQTVKLLKSKNKLHKSPYVAKKQEDKQANDAALGTGLHYDVRDIGLTLTVYTYRYDCWYPCTIVGYDSKRKMHCCLYDFGDKQWTALRDKKFQVMGRPQDTSPRERSQPPPPPSPKRKTSVSPRASNNQRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WF99</accession>
    <name>A0A6G0WF99_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VPS9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_016444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000253">
        <property type="protein sequence ID" value="KAF0725046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WF99"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000012"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF25">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN AND VPS9 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="1">
        <location>
            <begin position="247"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0725046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="413" mass="46040" checksum="98B1C49E8CA0B0C5" modified="2020-08-12" version="1">MEDESMDLTANENCYLARQSPASMGRVRAMTVPLRRQYGFRSFQMLRQEHDKQEFAKLDSNNGIRTARIDQVVASARKRRVGSSSPQKLKQSVFAALFVDLPSVEKQALAQLVDADFVQTMKARLASREALPEDRITAHFSNIFHATPIATPLVRPIKHSLGNVLLEFARVFHTLYMDFVDSNQKEDIVDRATADVREFSELMVQVVKFKYPFLPPDCSNLVEQAVEDALFVHLQPTLHGLFMAQHRGEDAELASQTTSLRQRADIMDLLEMEPLFRLNGSSSTVLPTSIKSQLTLARYAQATALMNDLPARRSPSQKIECIAQVCHCIDDSIKAFYATHPNPPPLEKLHITADALVPVLAYVVVMAGPIACHHLASHIALMDAFLPHRLSAGHGAFSLTMLHGAIVHLQSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WFK8</accession>
    <name>A0A6G0WFK8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_015496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000222">
        <property type="protein sequence ID" value="KAF0726220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WFK8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021360"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0726220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="393" mass="45022" checksum="B0A6F9897C616BFF" modified="2020-08-12" version="1">MVQVHDDTRQTKAATVRWSRLSVCYTGLFVLKLATTVRSSPLLAYLTEPLPSLIPQRSVVVYDSFDAFTNATFDFLHELYNDQTMATGRDTHFDSRTLTFVHRRPVVLPLEALSPQLFNSHLIRFPGAMFYGRGMRTFVADFLGVNAITRRQSRLLQCQRAYYFGMVWMDVCLWLEPLMPDETSSEDVYMAYYATVVWASALWGWFKLSLRCLLTLFILRVLWQRYCRHYISLLHALQDIGVEERFSRYDVIVGDPTYLILSDPRVSVAMVADIVTATAYVTWSTLRVCQFTDVTAFCLGCFYSTRFVWQGYLAMRFLSYVAKARRWELKFAPIDPGMLGLVALLYGGPVISLLGTTSLMAIFHTSWSLGLPSRLEFQAIDYASGEMKTSLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WGV5</accession>
    <name>A0A6G0WGV5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RxLR effector protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_015350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000217">
        <property type="protein sequence ID" value="KAF0726382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WGV5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017427"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026137785" description="RxLR effector protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0726382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="173" mass="18737" checksum="AB21C468513CCB8B" modified="2020-08-12" version="1">MRTLTLLALAASAVVAFYQPHRDMAVRQDSIDAPTNGLHELDGARRLQWTRSRGKQANYRGYEASPSTQLLDLNRRLQEGKYAAKLRKGCGAVGAACGAVGGAARFAAHAIMPARGDRLSYGKRLKLEAKVGAGVGRERGREIAGRWGAKVGKVKDDFTAKRAAKVQVHPSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WHP6</accession>
    <name>A0A6G0WHP6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_015105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000210">
        <property type="protein sequence ID" value="KAF0726706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WHP6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012025"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827:SF1">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0726706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="189" mass="20605" checksum="4289603E31B50DC2" modified="2020-08-12" version="1">MTATCFFNDCNNSVVPGSWKCSFHKNRSRCLVKSCQNQVYTRNLCVRHGGKRRCDAPNCSRNVRLGNFCSSHGSGIAKKLCIEAGCTNVAHKRQRCVRHGGGRQCKIHGCKTHARTGGYCCRHMRLVKAGVPSPDSVASPSMSCPGKEVAGDNVKTVDELLADFGALTCGKGLFDVPHIELDTILLMEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WIG6</accession>
    <name>A0A6G0WIG6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_014856</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4G family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000203">
        <property type="protein sequence ID" value="KAF0726991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WIG6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013843"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253:SF9">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MI" evidence="5">
        <location>
            <begin position="655"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="132"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="220"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="531"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="587"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="627"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="648"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0726991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="811" mass="89025" checksum="57E905A85F7082E4" modified="2020-08-12" version="1">MVDTTKSKLNAKAPAFVLSANAPSWQPSNVAFTKPAAPVPSLNITAKEFVPSFVVPPAPVVVQTPVVVEPVVDEKPIAPAVPTVVPAVAEPVVVVEKEVKPVEEVVEKEVKPIEKVVEKEVKPVEKVVEKPAPTTVPAPTPAVVKIEPEEESHPTSPISVASTESTPSPSESSEKQASPGRKRRITYTVAELLEMEPATCPVPTGLVLCLGVPGESKAARAAFTKPEHHSRGKKSHKKHKQPSHHKNHIDEDSLPPVKPLSINEETRWKPKIALGAKEELTTDDYLKQVQSILNKLSVEKFDRLSDQLIEVAVTNEEVLQGSIDMVVKKAQMEWHFSTMYAELCGKMARTDMPLISDTNAAKLFRTLLLTRCQKEFEVSPLTALDAEGEHISEEARQEKALVLKRATLGHIRFIGELYKQGMLSARIMHECIQRLFGNLEAPDEESLECLCKLLATVGARMEERAAAVPTEAALFKQYFDLIASLSKAKDKLCTRVRFMLQDLIDMRANKYVARLKEAKATTIAEIHAQVAREEKAKTSSGPPPSSGKPKFHKSQSMASLPPPPSDGWNTIPSKVKLTKSVSAELRNPPRSEKRNDERSKPRPRRGSVERERRHTIDRPNIPRVPVETPPAAAPAPPQKSQALPPQAPKERDEEAVKKSAKSMFKEFVYEQDIAEVQTQLHDALKYSMAVTTTVINYALEQKQAERAAVGPFLSGLVSANLLEVAGIVSAVNDLLEFLEDVEIDIPKAGLYLSEMVAPLVGENVLALDQINFAVLPEAKQSKVQHELASVLATLDVKDNEAVQAFIAAHNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WIU3</accession>
    <name>A0A6G0WIU3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GOST seven transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_014850</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000202">
        <property type="protein sequence ID" value="KAF0727114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WIU3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011521"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053937">
        <property type="entry name" value="GOST_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009637">
        <property type="entry name" value="GPR107/GPR108-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229">
        <property type="entry name" value="LUNG SEVEN TRANSMEMBRANE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229:SF2">
        <property type="entry name" value="RE59932P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06814">
        <property type="entry name" value="GOST_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026311419" description="GOST seven transmembrane domain-containing protein" evidence="8">
        <location>
            <begin position="22"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="GOST seven transmembrane" evidence="9">
        <location>
            <begin position="163"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="422"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0727114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="456" mass="51814" checksum="EE5BB3575D1ACF96" modified="2020-08-12" version="1">MRWPTTVSAFLLGWLALSASALKQSWSFKEETRRQFLIERFGFDVGGQMDVQVTIPALTSQAPRSSILFVHENDLVEDAGAYFAQPYNEDLCLLDNQQATTDRIDFADSATWHLSHAVKKAGFYYLLFAHCGDTDTILTFSMDASFMNPNDNYLSSGDASLPLIYLLTTFIFAAGLVLWLRLLCRANRGDIHHIHHMMSILLVLKIFSTFFESMRFYYMKTHGDTLTSWNTLFYIFMFLKGMMLFVVILLIGTGWSILKQHLNRMEKNVVFFVLVLQVANNIAVVVLEESSVGTQSWVHWRDAMHLLDILCCCAILFPIVWSIRQLRETANVDGKAQINLRKLTQFRAFYVAVVTYVYFTRIALYLLAASLPYSLTWLTVAVAETAALVFYAYTGHKFQPQAAHPYLALSTQVDLDEFGLDDEDPEVGPALQRKLGKAPSPRRSQINPKTPSEDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WLA0</accession>
    <name>A0A6G0WLA0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_014052</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000183">
        <property type="protein sequence ID" value="KAF0728045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WLA0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018056"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="187"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="107"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0728045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="233" mass="27178" checksum="6A4F6E583BC8E436" modified="2020-08-12" version="1">MILQPYLKTSLLKHGDLAKAVEKLRLDAKKNDYSPTSRRPVKETIVTPRFKQNDYVKVYRGQTLRKARVVHVTSSEYFVHYQGYPTSSDEYVPHYRVIEDREMKTSNTAVDDELEQLRQENRRLKEQLRESQEKLKRAEDEIAQEWMHECSVLQAKCLLVSDHCKEAVTRVYNVLEDKQRVIDSWNCVVCTTKPVDCALVSCGHLFCMSCSAQFESCPICRQAFVLRLPLFKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WMD9</accession>
    <name>A0A6G0WMD9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Branchpoint-bridging protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ae201684_013693</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the BBP/SF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000176">
        <property type="protein sequence ID" value="KAF0728507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WMD9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010040"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045131">
        <property type="term" value="F:pre-mRNA branch point binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02395">
        <property type="entry name" value="KH-I_BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000047">
        <property type="entry name" value="splicing factor-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045071">
        <property type="entry name" value="BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032570">
        <property type="entry name" value="SF1-HH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047086">
        <property type="entry name" value="SF1-HH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208">
        <property type="entry name" value="RNA-BINDING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208:SF45">
        <property type="entry name" value="SPLICING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16275">
        <property type="entry name" value="SF1-HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 12" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="12" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="14">
        <location>
            <begin position="370"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="70"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="560"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="572"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF0728507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="582" mass="64720" checksum="A188D0B326F23C5A" modified="2020-08-12" version="1">MEESNGRDSAYDKEELQEREALMRTTFQPMKKWYMENPECSEKFGPFPMFWQDLKTWDPYRDVQRLFLKATEKSNENPVNDGDETEKVKSDKGEEGTTKRRRKSRWGDATDTETSEKPARKSRWGATVENGEEEAAPPPKKKSRWAPVGAAGVDGVSSHLSAAEQQSIVLRAKLDALALKMATVAQDAAIISKDPNRSPSPPPIYDAQGVKLNTREARMRAVYENERMDIIGQLVEVNPLFKPPPEYLKARLQRKLPIPIKEYPTYNFIGLIIGPRGNTQKRMEKEFNCRIAIRGRGSVKEGSKGKKITADDHEDLHVLITGEREEDIERAAAEVAKLLEPVDDTNNSHKQKQLRELALINGTLRDDDYCHICGEKGHRQWECPSREKTFKPVDVRCSICGDTSHPTSDCTQKGDAQEKATIDKEYLSFMEQLGESKQTVISHGNGSTNGTENPTQQAWGAQPTIVYGSTPETAFPPPTAGGYGYYAQAQWDPQQVQQQWATAATAGASAYYAQYFAAGWTLHNGVWYDASGVAQGYAQEGVQQAYTYNSATAQQGAVAAPEASGASKDSDAQQFMNSLSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WML2</accession>
    <name>A0A6G0WML2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhamnogalacturonan endolyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_013516</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000175">
        <property type="protein sequence ID" value="KAF0728551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WML2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000447"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016837">
        <property type="term" value="F:carbon-oxygen lyase activity, acting on polysaccharides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10317">
        <property type="entry name" value="RGL4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1120">
        <property type="entry name" value="Carboxypeptidase-like, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029413">
        <property type="entry name" value="RG-lyase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029411">
        <property type="entry name" value="RG-lyase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016590">
        <property type="entry name" value="Rhamnogalacturonase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015364">
        <property type="entry name" value="RhgB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36574">
        <property type="entry name" value="RHAMNOGALACTURONATE LYASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36574:SF1">
        <property type="entry name" value="RHAMNOGALACTURONATE LYASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14683">
        <property type="entry name" value="CBM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14686">
        <property type="entry name" value="fn3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09284">
        <property type="entry name" value="RhgB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase B N-terminal" evidence="2">
        <location>
            <begin position="75"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonan lyase" evidence="4">
        <location>
            <begin position="343"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonan lyase" evidence="3">
        <location>
            <begin position="424"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0728551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="592" mass="64526" checksum="2CA2E8CBB849F42F" modified="2020-08-12" version="1">MGDRQWTNSDLWVGLGFDRTWIFSTEATSQRKGPKLDACTISLSTKITTMGAAVLLRAALALVAFVCVAGQSFGFTASSDGRKWAINTGNGLIVTMLRSTCDIISLMYKNQELQYSAKFTHINSGLGPVTSQIATTTVDGKNTIQITCAKTGITQYYFFRPNENAFYMGTYHTSEFEPGNLRFLARLNRATVTTGIPEATLDDTNRAIEATDVYATAANITRSKFYSAIPFIDDHIHGVYGPKAGVYLIMSDKAYETSVGGPFFQDINNQCTTANELLVCLNSDHTRTEDYRYGFHGPYALVFTDGPAPSTSIVDFSFFQKTNLQEFVPDSQRGRVQGTINDPTAVLTGFNIVVGFKNAQAQYWTRVAPGSKLSYQSPLMKPGQYTVTVFRKQLAVATGNAVVSTGTTSTSDVTVAYTHTQTPLWTIGVWDGTPDGFRNADKIHKMHPSDARMTPFRPFTFTVGKNVAGDFPLALFRGVNDPLAISFQLTSQQASQSRTFNVGITLAKNSARPTIRVNDKWNGPILASFAVSTRGDTRGVTTGNYFLYSYTIPSSALVAGTNKIALGIASGETDPPEPFLHASVVFDAVELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WMV2</accession>
    <name>A0A6G0WMV2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_013643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000175">
        <property type="protein sequence ID" value="KAF0728685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WMV2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015402"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0728685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="356" mass="39888" checksum="30CA378750EE44CF" modified="2020-08-12" version="1">MSGFGPAVTVKKRSHSDAWDDRVAASLDASSKIRRPTDVKTEHAYSSDDGDDDCIEENEQMYMPYDEKLGALHSSDEDDDERVKREMSGSDTEDETTKVEDEDQEDEEPWYSGLSEVATASQPDTKETGAEEDKNSIAEAWTVMRGICTELSHAEVHAINHDLPISGPPSCPPDTLDNAMKTYFRWPIRPCNLLRTNFAQDAECISIDLNEVDGREDNVEVAQTCLPALVAPLCNLVTKECRRYIVSTPKQDEAPILRAKLSHLVRSSTAFVDTLLETLLVENAVALQGNEKEYSSRAWSSVQNTPCANYRFVSETVQQPLLSRHLAPATIERIQARLHAIYDDSWKHEDAKECHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WNI0</accession>
    <name>A0A6G0WNI0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_013351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000171">
        <property type="protein sequence ID" value="KAF0728919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WNI0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010839"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0728919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="136" mass="15555" checksum="275FBBE3564154BE" modified="2020-08-12" version="1">MNATLVPYTYPPSYQGVNAAVNAKSKAFSRYLVLGIASFTMITFTWMLFGLTWKRPRWWFATLTRWFHISDPESTSQLMALAGSSRVRQRVPANSAMAISLEAWRIHQEEKHEPPPPIDQLEQPYYVAPATPPQEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WNT5</accession>
    <name>A0A6G0WNT5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone deacetylase</fullName>
            <ecNumber evidence="3">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_013291</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone deacetylase family. HD type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000170">
        <property type="protein sequence ID" value="KAF0728990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WNT5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001829"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF5">
        <property type="entry name" value="HISTONE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="11">
        <location>
            <begin position="197"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="69"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="106"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0728990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="586" mass="64989" checksum="BFE9599BBF94B508" modified="2020-08-12" version="1">MEDVGSSNKKPTTPSGARNTPLHETKARNSPLIPYSPFLMESYHMSANLGLSASLHGFSSPASFFSGCPSDDPHSDHDDMYSSLSHLPSASNKVTQHHGAEKEHTSDDDDDEEEQDEDDDDEDLAASLWNCLVCTRLNQNDQCVFCGQDRDRPFEPQPPRTQPRQSQAPRPVQTAIGYDDRMRFHREIEPRDKLDLHPERPDRIAAIYAQCQQDGVIERCTHIPSVLVDKADLLRCHDAEYLDEIHQLFQLPFHHITPDTYCCRDSDTAAKLSAGIVVSLVDKVLRREVRNGFAIVRPPGHHAESPHAMGFCLFNNVAVAAKTAVEKFGLRRVLILDWDIHHGNGTEHMFHDDPTVLYASLHRFDNHGAFYPGTGAPDSVGSGAGAGFNVNIGWPSGGMGDAEYLAAFDRVLMPIFRSFVPELVLVSAGFDSALGDPLGRCRITPTGYAHMTHLVSSLADGKVVMALEGGYNLKSIAASASACIQILLGDAVPPLNDMSPPMESALRAIETTRRCLEPFWPCLCVVEEENDDEDDNDDQASQQDTLAAKVELARRLDPRILADVRAKLLEKRRQRYRPYRPSHKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WP50</accession>
    <name>A0A6G0WP50_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4419 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_013241</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000169">
        <property type="protein sequence ID" value="KAF0729105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WP50"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012137"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025533">
        <property type="entry name" value="DUF4419"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31252">
        <property type="entry name" value="DUF4419 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31252:SF11">
        <property type="entry name" value="DUF4419 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14388">
        <property type="entry name" value="DUF4419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0729105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="361" mass="40610" checksum="EB1536BF17AA133D" modified="2020-08-12" version="1">MTTFAVSPVQVENYRRNLCEQNDDMLTRLKEFKKEGCKEILQATPIKGVFAPTNSAFVLGAIEAYNQHHNLVIRPDDVWLAIMIQFGFFVNGNAETLREALVKHQGQKELTVTEFGSLYTVDYGKMAAEMIGKMEEHLVDPSLGEWILPSFSTTTDHDRIVGSVVMMASMKKYFKYKFELCCGIPNVTLLGTVQDWETIRSRVDYLKRFGGHMVEWVEMLSGVIDQFVASAKGAVDVDFWQRICHNIGGGSGPRYISGWISVFCVFDEEGHWQGSTKSVTNWGRVTESEFPIINTNDIPAGYLTVDVLIDDNGAEHKSLMFAGHMSYQVEDKKTIIPTLSWAIVLKNGEVPSDSSMDERFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WQ27</accession>
    <name>A0A6G0WQ27_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Expansin-like EG45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_012961</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000164">
        <property type="protein sequence ID" value="KAF0729463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WQ27"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002142"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22271">
        <property type="entry name" value="DPBB_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.760">
        <property type="entry name" value="Expansin, cellulose-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007112">
        <property type="entry name" value="Expansin/allergen_DPBB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036749">
        <property type="entry name" value="Expansin_CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF21">
        <property type="entry name" value="EXPANSIN-LIKE PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50842">
        <property type="entry name" value="EXPANSIN_EG45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Expansin-like EG45" evidence="3">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="199"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0729463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="311" mass="32993" checksum="6B0A7D3F54146767" modified="2020-08-12" version="1">MKYLPSATAYHVALNNDQYDSGANCGRCVKLSCTDSRCKNTAPVVAQIVDRCPECKHGDLDMSLQLWNAVTGYPSDRVKITWDYVDCDVQGGIQVCAKEGSSIDWLYVQPGNTRAGVQSMKINGADAPIFASAYYFMSTILHTIPLSQTTVEMTAYTGETIKASVSLTANQCTQIPQQFQGGAALATPTVAPTVPPTVAPTTQAPTQAPTHSPTPKTANATSALSPVTTTIKSTVPPRLRRQRPALLALGSNVVAMDSPARRCASVATSVKEATNGTPSVSPSRNMPMKLVCVEADRVGACVCACVRSFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WQ46</accession>
    <name>A0A6G0WQ46_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_012979</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000164">
        <property type="protein sequence ID" value="KAF0729484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WQ46"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012441"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039121">
        <property type="entry name" value="NUDT19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12318:SF0">
        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE NUDT19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12318">
        <property type="entry name" value="TESTOSTERONE-REGULATED PROTEIN RP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="7">
        <location>
            <begin position="4"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0729484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="278" mass="31348" checksum="64BF5148283EA7DB" modified="2020-08-12" version="1">MSGKVREAACVVVFNHLEQILFVKRPKTSKAWANVMVFPGGKVDASDDNGHPSPLPHVPIRFLNAAIRELFEEVDIGLTTPSLYGHFTQEERRQWRKKIVQGETCFDEVTRSLQCTLRHEALVPFHQVTTPVGSPHRFDTWFFLTQISQAAAAQVETDGLELEELLWLTPKDALDGYAAGNFMFATPQFYLLHHLRQFDSWNHLVSTAKAQAKTPQPSVLPQRIPPSAEFPGTLTAFPGDPLYEPRIAFPFLHRVYLHPTDPAKSSVHLPPVLPSRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WQD6</accession>
    <name>A0A6G0WQD6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_012854</name>
        <name evidence="3" type="ORF">Ae201684_012855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000163">
        <property type="protein sequence ID" value="KAF0729587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VJMJ01000163">
        <property type="protein sequence ID" value="KAF0729588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WQD6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011811"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38899">
        <property type="entry name" value="DOMAIN OOKINETE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38899:SF1">
        <property type="entry name" value="PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0729587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0729588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="227" mass="24975" checksum="7A31F509C1705739" modified="2020-08-12" version="1">MFTVAQQTPSRLTKTPQRSKPIRSSPPLNVTKATVFSWHDFLCPVAWLQQQQFVMPPSPALWQHLAILDQCIVQLVLQARSLGPVFVLCEDGATSVEALCGTFFPRCAHLFSSREMQQHIQLICAATPLSSIWHGQILHMICKDRLPRSGAYSLTVFGGDGMRSGGLALAQHVKSVQAKVVRPHTSSVAQGLKGTLESLVHATKVLGSIVQHHDHVDMMLQPAPLFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WQG7</accession>
    <name>A0A6G0WQG7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_012885</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000163">
        <property type="protein sequence ID" value="KAF0729621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WQG7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005879"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
        <property type="entry name" value="FYVE_like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="7">
        <location>
            <begin position="258"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="451"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="528"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="487"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="528"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0729621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="599" mass="67301" checksum="B784846E96A27F80" modified="2020-08-12" version="1">MLPADVLSEREKEHFTNIAKHMTQALLAATNVSQAMPWKLVYDKQFSIYRTELCGLGPCNVHAVTKLVAHIEEVTEALITTTTEAYKTMMTTLSSDFVDGAVLANILTPTPETPFRYVGLKWAAFKSSTMSIRSKDKDFIILEYVDLVEDARGNKTAFRIMQSVDVPDSLDTAATQGRYTREQVPLVGFLYYTTPKKGELRMTYTCNVDTKGELPTWAANTAIQSHVEKCITRTLKYIEFQRVRSDSFELPQRVIPMSGETGSCHVCDKKFNFYRHRYSCLKCAKYVCSNCYSLRTAAVPDHGERRCRVCTACVIQVRQARRGSGDIKKEHLDTTVQLHERQSLHDLLNCVRDLVANDYKLFSSHPPHSFHHLPPSHGPPPAAALARRRVTVGPQELKPSLDMFKEGQAVRSVPAQRAAIPDKRRSTVGPTDLQSSLAKFHQVYNVALSVASHREDDETSEDGSMGMISSDSEAEDDSDPGQFVPLTEHALRKLDMWKEKSKSLEQQSEEINKLANCLARQLSDSHSALSRKSSAQSVHSRKASSSTIVLYDMDQGQPQHRRDDNEQLRAFLQSKGAKRRSSGSEVAKSYQHPSSLFMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WQN3</accession>
    <name>A0A6G0WQN3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_012637</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000161">
        <property type="protein sequence ID" value="KAF0729746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WQN3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006955"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="360"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0729746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="909" mass="104208" checksum="A6E99DE019D505BE" modified="2020-08-12" version="1">MADEVFAAVSSGDVDQVRQLLEDSPANVNAIKKINKVSYTPLMVAAEQGDVDMVEYLLSHKEINVNRPSSETKKTPTPLMRAITKGHEDIVRLLIQHPDLDVNEVMEKNESAIQKAAMHGRVTIVDLLWDKVDLPSKERCLDAALNANKFEVVALILEKGFECNLKFRGHLLLEFVARYLQQEAFVEMLLRDLPFDIQDGFIVVRTNHLFSWTTFLKPTLIVGESVSKESIVEALLNHKLFKNLDRESLARHLVYSKDEYGREAYFVATADMRDFLRKQLYFANRYEIIEGPPMHASESAVILLAYDHGICTQVFHEYASMEGLNLDGFINCNNLLGRLSTDRRASDNEETVEQLWSNEFDMLDTSNGGLMSEDTFKIYCEKHFGSKLKVALKFMRYQDEYNREITIRKQLDAKFALGLLPSLDESVFREHAVHLKVDDELSMDEYPFVLVMPAADRSLEDVYLKERRSPTYIRFALEEVVLALQHLHSKAIVHGDLKKLNVLRVHNGFKLIDFDASTFEGKPMGMKFSSGILPPEMFYKLQNSSERAQYEQSCNLDEWSKLRPKHNFVVRSFRGEEKVPYSFVEASPSVDMWALGCMMFQLWTGIELVSTDVNQDVVPDRIEIAATWTDEKLKAYIEENIQCRVKRDLLQHLLVVDPRQRISCQDVLNHPYFTGTDTVNSTRANEKKVAPQNVRFDTAQFSGKAPTTFVTLPFRVENRQAKDVLLDFSQFAARFAGFCHQILANPTRRTPREMIDSFTLGKPMYFYLVDEIERKLAVNDFDAVYPIEIPPNQHLLLSSMLPFVQRGLKLVLHEHSNQSDALSAIQEAHRLVESVPPLAFDLLASLTTNPVHDVQQLALDMLEQFYCERDPEDSFAGLERVMTSERTLAWTSKSHAHAIRRRRTELLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WR01</accession>
    <name>A0A6G0WR01_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="12">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ae201684_012518</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="12"/>
    <dbReference type="EMBL" id="VJMJ01000159">
        <property type="protein sequence ID" value="KAF0729876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WR01"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013549"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006413">
        <property type="entry name" value="P-type_ATPase_IIA_PMR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01522">
        <property type="entry name" value="ATPase-IIA2_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 12" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="10 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="120"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="312"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="529"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="14">
        <location>
            <begin position="39"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF0729876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="935" mass="100524" checksum="E60678B8A8807429" modified="2020-08-12" version="1">MWLRTFVVFRPKTHTALSPPTMATPHGFSADGDAVPSPTPSERTYSDVANELEVEVSSGLTSSQIAARQKQYGRNALENDEPESLCMKFLEQFKNPLNLLLIASGGISILMGHLDDAISIVVALTIVVTVAFVQEYRSEKTLEALKELVPPRARAIRDGSLCEVEAADLVPGDVVVFSTGDRIPADARLVEAIDLEVDESSLTGETHVVAKHTKPILSAHLHPIAERKNLVYMGTLVRGGRGKAIVYSIGRQTEFGLVFEVVDSVEERKTPLQTRMDGLANQLSMVSLVVIGVIVLFGVIQGQPLFKMLQIGVSLAVAAIPEGLPICVTVTLALGVMRMAKRHAILKKLPAVESLGCTNVLCVDKTGTLTTNQMTVVEVFLPGLGSTPTALLQQPADATQKAKFGPLLLSGVLCSNAEIVDGDIVGQATEGAIVLAAAQLGVGETSSLRRQYPRLQEIPFNSEAKFMAVQCSVPQTGAIEWHIKGMLEAVLPRCAYYQDASFQKHSLLGPDKDLIQQTASAMARRGLRILALAVGAASVESNMILLGLVGISDPPRPGVRSTVEQLDGCGVTTIMLTGDAFDTATAIANQVGILENAADSNACCSGQELDTMTLAQVQEKVLSTRVFYRTVPTHKLKIVQALQANGAQVAMTGDGVNDAPALKAADIGIAMGTTGTDVSKEASDMILLDDNLATIVAAMAEAKGIYHNITHFLRFQLSTSVAALSLVAFATLFDLPNPLNAMQILWINIIMDGPPAQSLGVEPVDGDVMLEGPRAAHVPIITRAMLKRVIVSASLIVTGTLYVFVQELDADWHVTKRDHTMSFTTFVLFDMFNALSCRHESKSIFTIGIFSNSAFCKAVGASLVGQLLVIYVPFLQDTFQTEALSLGDLVYMTAIASTVFIVDEVRKLWDQPRSGWPWQKPQKYSPVWEQADTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WRR4</accession>
    <name>A0A6G0WRR4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_012403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000156">
        <property type="protein sequence ID" value="KAF0730108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WRR4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012222"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0730108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="106" mass="11693" checksum="5F58DFB471863FC0" modified="2020-08-12" version="1">MATVPLAKVAAAFLFSLPNLRRLKRSMDLCYTSAAHGLHTEAPSNEIVAAMEQLKRQRSAVEDKRLQLAQSLERDENSQSASQQAAKTPSEFARLFHDNVVPSPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WS67</accession>
    <name>A0A6G0WS67_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_012317</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000155">
        <property type="protein sequence ID" value="KAF0730319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WS67"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018376"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="37"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0730319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="323" mass="36919" checksum="BF7BF42FC7F8ADBF" modified="2020-08-12" version="1">MSATIPPPEDASWNHQYAQINGIRMHYVDVGPRDGLPLVLVHGFPDLWYGWKHQIVDLRETYRVIVADNRGYAGTDAPAEVESYRRKTTTDDYAQLLDHLDIKQAVFIGHDWGGDVVWKMCLFHPDRVLAVAAVCTPYFPPSPVKLTLEETVKKLPEFEYQLTFSAPETPAIYDAHASNFFNAFYGNPLAEEVEGGLASWVKAVPNLKFKLSHPPLLSPEELQYYIDQYLRQGFFGPLCWYRTGEMDWDDLTTVESPIINHRTLFVLGTDDKALRPYMSAHMEKFIPNLTRESIEGGHWLLNQKPQEINAILRKWLEPLTAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WT81</accession>
    <name>A0A6G0WT81_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">YHYH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_012083</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000153">
        <property type="protein sequence ID" value="KAF0730664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WT81"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011709"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011692">
        <property type="entry name" value="Stress_up-reg_Nod19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33390">
        <property type="entry name" value="STRESS UP-REGULATED NOD 19 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33390:SF1">
        <property type="entry name" value="STRESS UP-REGULATED NOD 19 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07712">
        <property type="entry name" value="SURNod19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026354216" description="YHYH domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0730664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="459" mass="49995" checksum="CE5A7946109F34A3" modified="2020-08-12" version="1">MHFSTLALVTAVATAARRSHTAYTRPIVLPQGGVSNDYHVLPIPKGPIAVYRFAADIVEILPDGTVVPTPNYDAYLHHHVVGSRHSSYKNKQKTWTPMKAPEMFAGVGFGAGTESRGTPQEFSYPYAFITSPGEDEWIANVHIINTRKMTTKNAHHCLECPCTSNDVFANGTVNGFELGLHCNTQLLHEKNSACFADTYRGGLRCCNDQELCLEPQDLDPVVPNATYYMRYTFDYDDVQPDNRGLYLAACCDASGDLSRHGAVEYDIPQCNPAENPGCTHTLSTRQHIGRAGGAFGFGADYNEEDVEVELVYAVGHQHRGSLGIQLYDDKTDELLCNSYPTYGSGNVAGNESGYVIAMSHCTFDPPRRMRSSDIVRIVATYNSSEPHTGAMSLWYLAIADYKPPQDSTVSHSAVPAKNDNTPVIVVGALAAVVAVGVVVALYKRSQARAGYAKVGESVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WTV5</accession>
    <name>A0A6G0WTV5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_011757</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000149">
        <property type="protein sequence ID" value="KAF0730875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WTV5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012838"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="267"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="6">
        <location>
            <begin position="17"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0730875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="331" mass="36835" checksum="07FB8D9F8BDC8356" modified="2020-08-12" version="1">MPDVSLARRIVNVTWPCALYLCCSLSMNLLTKTVLTVYGWRSVYTLAASQQVFTVALVLGGWAMQIVRLEPMPWRFFWYNVVPMALLNSLNGLIGFVCMQLVNMPMYLVLRRLTTFKVMLMEIVLLQQEIPDAMQAALLVTTIGSVVAGCNDATFDGYGYLLVIFQNCCTAMNLVLTKKSNLTPLMLVVVNSAIGMVFCVPLAMHFEYDDVVDFLANLEHPTQFYSLFVVMSTVCLLYQVAIHLCTIRTSPLATSVTGNIKDLASTVAGFLMFSDVVITPSNILGVALSFLGAYAFSYVKYNMLFVPHSTVTKPWRLRKAINSPSTKPKAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WVB9</accession>
    <name>A0A6G0WVB9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_011314</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000143">
        <property type="protein sequence ID" value="KAF0731411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WVB9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017234"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0731411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="427" mass="48859" checksum="0F5F9A15F1B9A174" modified="2020-08-12" version="1">MKKAKTSKATSLPTEIVVKVAFFINEWSTVVTFLDALRPAKVLGPLEHLWQLHLMSWKERALWPSLDLADSDQASKVHLEGIAKFYSKVFVDTTTDRAWFRQILDPAASGHWACRDLPSKASRCVDLDTLNQWKPIRIVSIDKNAIKTNLVIETLSCLPYLSEITWQICEHEIAATLFQYAASSSSLRKLDLKDFGTTCIDMSTCMANNLMKWVASQPVQFISIKGFKWKNIDQRHQFMTLALEKPTFDCFGWKVLNGSERRTRGWFNRRKKLALFTFRGPSHSGHDGLDVDNLRGFITGFRPIFHDGVQTLLIFGIDHIGHCNIWPILTSILRQSKVETLILRYDKMEMTEADLFAEFLRHLPALQELEFRTKVSFDLLVVFINAVLPTVKRITTACPSPDLLNVLSEREALDALALERSIEFVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WVE1</accession>
    <name>A0A6G0WVE1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alginate lyase 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_011345</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000143">
        <property type="protein sequence ID" value="KAF0731444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WVE1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004012"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014895">
        <property type="entry name" value="Alginate_lyase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08787">
        <property type="entry name" value="Alginate_lyase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026275372" description="Alginate lyase 2 domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Alginate lyase 2" evidence="3">
        <location>
            <begin position="22"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0731444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="254" mass="27875" checksum="41C0A17132F90EF7" modified="2020-08-12" version="1">MRSLTALLALVFAAGELPSQVLNLSIWSLDTPEDNGSGNSRRVYHPALDKYDNKYLSVPSVGDKFVQLLVPVNGKTTPNSHYPRTEFREVKPNGKGSGDNMDFGLTGSHRLDATLAVMKLPPKRPGTAVGQLFGDGPCVMLGVKKQDNKYKISASNHFDNWNVNEIGVLDADYKLGTKFSYSIAYQNGKLTISYNGKTVINVDYKEDHQCNCKSGSDALCYFKAGNYLQTNTDYDNANDVGIVNVYSLSTKHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WVF7</accession>
    <name>A0A6G0WVF7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_011148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000141">
        <property type="protein sequence ID" value="KAF0731523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WVF7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007365"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0731523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="32912" checksum="9D3903C9B5AA3068" modified="2020-08-12" version="1">MVVLVRVYRWRCSKTLQETFDLVLLDLLSLWRACRVCMVGNSILDVYLGRVYNVLCRLRFERDGDHVWEAPVAQPPIECAASLRFHVHPTKSRFYALKVTWPATSATWNIRHSFSHFSNLRRDLTAIFHQLQLPLFQLRWILRSALAQPWPKKSWHHSRAVVAYRQDAFSNLVEHLMHVRWLCYQCHDPGHPALDDAFALVFALLDSFLEVPSTIPRRSPSMVVNNIDNPSRVDCAPAVHSDATKQVEVCHWPKQPDVVSPAWYIILLVIALVLFHFAWNTSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WVH7</accession>
    <name>A0A6G0WVH7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_011167</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000141">
        <property type="protein sequence ID" value="KAF0731543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WVH7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011664"/>
    <dbReference type="OrthoDB" id="72282at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0731543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="205" mass="23105" checksum="61AFEAF0EE613191" modified="2020-08-12" version="1">MAKGKPPRLEPLASVTYAQHPSQGAEELDVLKAIVAREMCLDQFLQLVTSFTASPGDILEALLVLRTTSLAVVEAVASWRSHMVRPLAFQWQGVNYIHRMASDADFLSKSSEIHRTLEFKLKRRNPFCTVPGLDSPFFRPRDADEALTFDPNGTFVERLHNAAMYILEEETRLGGPFKPASTDPRWAYIVQREAERSSQLRFGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WX89</accession>
    <name>A0A6G0WX89_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Neurochondrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_010826</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000137">
        <property type="protein sequence ID" value="KAF0732177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WX89"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002022"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008709">
        <property type="entry name" value="Neurochondrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13109">
        <property type="entry name" value="NEUROCHONDRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13109:SF7">
        <property type="entry name" value="NEUROCHONDRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05536">
        <property type="entry name" value="Neurochondrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0732177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="606" mass="66006" checksum="6B251DED4EE25857" modified="2020-08-12" version="1">MVDPKLKQCLTILAGNSDEHKFAGLLMITKHLQTEDEAVLQYVRREVVKIAGVPFFVRLLHTQNAQDDGISPFRSLALNLISSFCLDTSLAPEFATDTVLSAVLEVLPQAILTQKSVIIHDCVQILHGLLPFEIFKSHHGQKHIVEAIHTCAVDRPLLDADLIHLVSLLQASSPASMSLDSFTSLCETFAAISTPSNAKCELQDVFIGCLASDSTAALFLTASNVRCLAKGLFGAWPAHTHRSTRRDTSLRLLERLASICGGDWLLEQDGAAPPVIGLTLQMAAIESKLLLDDAERILIDMEIQQTPKDTVECDEILHRIQLLLPACYTIAEAVLESLTNIDNADSLSNTMLLHLKETLGQMFTVIIQYLTTCRDAIGSAAFQPSAAFDAITFATIRVLGAWMAQETDLLEEQLVVLIPFLVTYEPQAVEGGSDADSDDEVDTNDSGNSTLPFLLPGLLQLTATSAGAAAVLDNERVLQRLLQFTGVVCSQMMASKLDDGVGTLTMCLGICVNILLVSNASTPHRLFKKALPMLQSLTALTWKQAQDTASDEYVLLLHLVACVALMAPRLPTELQTCFAWIRAHPPSIDVESTYDLHELVLKLMAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WY25</accession>
    <name>A0A6G0WY25_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ae201684_010435</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000132">
        <property type="protein sequence ID" value="KAF0732445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WY25"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004779"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000009">
        <property type="entry name" value="Probable E3 ubiquitin-protein ligase HECTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF440">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NEDD-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="12">
        <location>
            <begin position="63"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="13">
        <location>
            <begin position="319"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="9">
        <location>
            <position position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF0732445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="662" mass="75467" checksum="41F5EEC053C9CBAB" modified="2020-08-12" version="1">MALPYEVYAAILVGVVLVLLAGIYCCWRSLVRSQGNAYRDLDFGPTFRNDVVLRENLEDSFLKEGKIEWQCVVCAHLNHPDKATCSLCGAAEVMTHCNSTTLLKSTSLNKSFMLPPRVDEIVGDEDMNGSGGPRHFAEARQRALIYRRNNMQLTQRQRQAKRRRLWQRALLPTGEYVWVRTATFVNSNGNRDDTFLQTLERDPKSASLDEMLHRKNAVSFGFVTKEDKETGELTWSRASLHGRQPHLGDIDELQCVDVEVADFVDVEGMMALPFKEKKTWFIKKIKQFAIPRVDALFAIRVRREFIFEDSVKLLMHSVDAGRTREYLHIAFEGEEGLDAGGILREWYLLVCNEVFGPTLGLFTITHAENKSYWINPASEMTMGPRHLTYFRFVGHLLGRGIQEGLVLDAYLALPLLKHILGVPISFSDLEYLDQDLYKSCVFVRDHDGADELSLTFSVQGSHADEVDLKPNGRNIDVTDANKNEYLALVLEYKMLGSIAPQLKELLLGLYEVIPRSMLSIFDYQELEFFMCGIPNISVEDWRKHTTVRYMRDGDVAVQKQVVDWFWTVVGRFSDEERGRLLQFSTGSSRLPVEGFKGLTSSSGQIYKFSIQMVERGHPPAGMCPKAHTCFNRIDLPLYTDLDELENYLTLVIQMEITGFGME</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WYL2</accession>
    <name>A0A6G0WYL2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VWFD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_010327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000130">
        <property type="protein sequence ID" value="KAF0732619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WYL2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013714"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026298646" description="VWFD domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0732619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="154" mass="16381" checksum="1A7108B4F593A295" modified="2020-08-12" version="1">MVASIPTLLLALASTALGHGYLNVPLPTFLPGVNDITAYCGTMDGPNILPGDQYNTSPENNANAFTTHFKASSYKTLKDFVAANDGGCGTCGHTDANGTPHALPADGNVYWHHGQEGYTPSHEGPCEVWCDNTRVYQNDNCARNIPNGTMPIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WZT5</accession>
    <name>A0A6G0WZT5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GYF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_009868</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000126">
        <property type="protein sequence ID" value="KAF0733044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WZT5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001112"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039905">
        <property type="entry name" value="CD2BP2/Lin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003169">
        <property type="entry name" value="GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035445">
        <property type="entry name" value="GYF-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13138:SF3">
        <property type="entry name" value="CD2 ANTIGEN CYTOPLASMIC TAIL-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13138">
        <property type="entry name" value="PROTEIN LIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02213">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00444">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55277">
        <property type="entry name" value="GYF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50829">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GYF" evidence="2">
        <location>
            <begin position="236"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0733044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="325" mass="37183" checksum="8C730681CCB5A7E8" modified="2020-08-12" version="1">MRRVNPGKQDDDHAWGGSKKQKSVRFDDKNRDDSDDEEYLNGGIDSDEEEVKEEVNSDEEETKEDGPKEKRKQGEEDERPDMPQYAVEGVRVIPFNLKEDREDGHFDENDNFVWAKEQVVQEDAWLEDVSAEDMESAERALILKSEARDDGEETWTERRATSVFMEILNDGETPLQALKRLGKKKKGSKGPEQTEEMKREFEELTEASDFLMRQGKTEVYHLPKEELVPHAPRPEPVLWEYKSQDGQIQGPFPSANFIAWQAQGYFKGESAVLIRRYDPQNEANPASTSAAKDLEDDFDDDGDDEEAGGEGGWVSSDTIDFAKHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X045</accession>
    <name>A0A6G0X045_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_009974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000126">
        <property type="protein sequence ID" value="KAF0733154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X045"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0733154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="277" mass="30848" checksum="094D1BB225CE636F" modified="2020-08-12" version="1">MDLELSLTDLELQWLANALETSQNDALLEDSDMDSLDEKKQLPAGNSQPPQEDSISLSVPRSEDSHQSTASDIASGQSITGNTCPALQPRPPSDVGPALSALIEQQRKRSAFLHSLKRHLDVVDSSRSFTSPLGRLRVLRFESRVASMVYLLKNFRPGSQIDSVGIFTLNNSLSHDGFLPHLVTFQHLWHAKAEAFYTLGQRLEFVASIDNDRSARACFDWPALTCLLAQGSSVNVRDGDHVLWRETIECKYVSYQICHATINLHSAQIIHRVTRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X047</accession>
    <name>A0A6G0X047_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_009952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000126">
        <property type="protein sequence ID" value="KAF0733131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X047"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021305"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="653"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="664"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="706"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0733131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="718" mass="81848" checksum="5F02599BD7B4AE7F" modified="2020-08-12" version="1">MGAVPSGRQVKDVVMHLFQTQHPHEAAEVMKFSILHDIQLNYKYIVSDAIKIDAAYEPIFVDLLQKQELPSSIAISIIKGFLDLRHIPQAIKYYKDIVRQSRGETEDANASQKYKFVHDVMENLILLDENPHPNAQVAQRLIVDNFFCEEMEDQDDVPTLRAVLEVNPSSMEWLVYQTIGRLNKRVNYEWQARQRRFESIFDFCLNNRVDIVYDAAYSMTLNCYRYAKADPQHLMMTYEAMYKTNLAPFNARIIVYAMHASLAAGNYVTSLKHFETLIQRIDPTEGNPSESIYSSGFMLCSQAGNEKLAQEAFAHLKQNPNIVPNQSLCNWLLRCVEKPKNWDLQQVLEYLVIHDFKIKGVMQLMNHSESDKNLIKKALGRISDKVSLPPKERGELLLKRIQAVNTQDKKDTSRLESLIELCFSELPTPASALALLEEVNKIAPRALQFTVQAIILSVCSPNFSWSTTNVDTVGALIKYCIEKKILLGRCFSLIHFFETVKKHTAALPPHFADMIEELVISKLVWRSMPRDMAAMHAYQQVGDYTSAMKVYKCLLKQNKNTEIDKTILSNGIFLCAKTGNEEFAKSLVDKLMQSEHFVPDRGTFKWVLKSIQTPSAWDIPKFVQYFGSHSIQPSPKQYDRLFQLMESTSIDTKTLGLRAEKPSESTSKVRNSRVSRTTETTAGDEPSTKHRSSAESKSAPKASVPEQKKEDSSRCSIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X071</accession>
    <name>A0A6G0X071_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_009796</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000124">
        <property type="protein sequence ID" value="KAF0733232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X071"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006307"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008443"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Peptidase A2" evidence="8">
        <location>
            <begin position="437"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="305"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="382"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="19"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="386"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0733232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="815" mass="91263" checksum="E13F0B8C193D66A5" modified="2020-08-12" version="1">MAAEIKKSRREQEKSRAILLQQQQQLQLQQEELKLAMAQQAKVTGDHQSLLQQASKAMRQQHSKVEELDKKVRRDSERWGLFAAAANQRPPVQAAPTAIGRPETLMGVQQVPLAPMYKGSTKRERREFMDEYLAYSRRVEALNRGVGGILFLMPLVACIDQKIVPRVCEHDFGKPFEEITEDEWRDYFLSAREVQKLDLEWVTKAMASLKMDTRIRDAESRVGRLLADFYEKLEQLDVAHLPSQEPKQSVKILTAAIRPAALKATVERQLPREANKVYKSSVPAFGRWLTQLLDNFMLFESQMATAEKKPEEKPARRQYGEKFRHQQQPQQRKPEGQAKGHGPAAKQGHFARGCLKCGSDDHKVAQCPKCAPGEAQRLLEQRAKRPPVAANTPAAAPSGKPEGKKNVVGATIDVSESKLEVLQEPRTVPCTVNGVDALALLDSGADQSVVSPALIARLSDAGALLAPVCKLESALELGGFMEDMKLSVDREVKLKLTFDTAEGRLVLTNLKCWVAAAPLHNGLGDVIVSRAVMARLGYSPRSLLETARRAQKVYDLGHLGGQDTCLMAAIKILEDKKKPPVAPEEVALNVDEELSCFPQAAVRAKLKEKVGECRVAGCDDSYAVELGKLLVKYEDVFRLKLGRDPPVKVEPLRVTLKADAKPVRCKARRYSKDQREFMAKHVDELQAAGLCYRNPRSKWCSAPLIVKKPEANEFRMTVDVRPVNAQTERILWPMPMLEVILDHLCGAQVFFTLDFFKGYWQFALHPDSQEMFSFLTDIGVYTPTRVLMGGTDSVAYCQSSVQEMFADELYRCLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X1F6</accession>
    <name>A0A6G0X1F6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_009290</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000119">
        <property type="protein sequence ID" value="KAF0733718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X1F6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013451"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF214">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026321536" description="Protein kinase domain-containing protein" evidence="5">
        <location>
            <begin position="21"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="516"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="587"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="72"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="586"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="114"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="586"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0733718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="879" mass="95073" checksum="A53CB7E363D252D9" modified="2020-08-12" version="1">MATVVWRSVLLWTAVFAVSARRPANEKTAADITVPVTTPASLRSFQADAWKNYQVYGFAPNASKMAAALATQGQNAKTTSKAKKGKKKAKKTTKNGARPLKKKTATIQALKVKNAPKKSSKLKKKASNKSNAKPKQAKKATVSKKKSKAKKAQKGKTLKKDESGTATASFKCGMTATLTTCAIGNASELCILSDADGQCTPQFIYPVNKTGDKQLVTVQDLKEVLTISALPENFDAINFDDLDRGVVAQGLTVPTKTTVFKITKSRLQGYPDPKFNGLKLPPSIERLDFSDNEMTTFNCTEWSLSPNNLIEMALNNNNLNNLDNVVIPSKLQKLFLANNIINSFNGTSFPPTLSYLDMRMNKVGAFAKLPFGDSSVLDTLILGENNFTTLVASDVATLPKSLRTLDLQHNKIVTIDAGTVWPENLESLDLSQNMIESIATLQLPKNLKKLFLNDNPVKNFTMSAAQFALLSNIDSVTMPPLTGACPRGYRSQSTSQSTNVVTVCVTYNGDGISSKLPLILGIVGGGVCIAAFAIYAYRRHHDREQCKLADEYAMLALEGNRQIGSGYRSNPAALARGIILGRRTTGSSAASSSGSGENESAASGKDRSTLSDYPVVLSEHPELVSVAIPCGAISDLSPFVGDTSVGVYNDHRVLLKPLFTDREVETIEMYATLEHPKVVHFVGVTWDLSGTLSIVSEFLPRGSLHAFLDGRRSSVPTFDVRLSLAVDVAEALTYFHFLRRPFVHLNLTYDTVLVAETEEGDVFAKVQLPVEVGAVSADKIWVAPEILRGDEPTPAADVYSLGVLLSALDGAGLTPLLEDTGDATCTGDHRYSLMFGDERLGELGSRCLAQNQAFRPSAMDVVYGLRNLVHEVRAIVLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X210</accession>
    <name>A0A6G0X210_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4097 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_009380</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000119">
        <property type="protein sequence ID" value="KAF0733814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X210"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010136"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050836">
        <property type="entry name" value="SDS22/Internalin_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025164">
        <property type="entry name" value="Toastrack_DUF4097"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652:SF3">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13349">
        <property type="entry name" value="DUF4097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="375"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4097" evidence="4">
        <location>
            <begin position="543"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0733814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1082" mass="117245" checksum="B0F1D3530F2841CD" modified="2020-08-12" version="1">MRAKANKLLWRQTTLPQATETTPQVRRVCVINFILCLGVVPMSFVFANKAMTFHYLYVAGAVLSIISLVASVMGILKSTPGVVWSLMLAVAAAYGLLCTGGLCLLYLPYLSAELTSATDKQYAKSVIASSALASQATTERTYLLIGGIAQLILGLLAAYMVRQLFYVLGEKRASVALLQSFSAFMIPLSLLFIAGGQYIISSQTFASSPYTGIFIYVCGLLELVLSLLAFIGSGFEYRRLLNTFSWFAFVTAILAIGAAIACLSVTSSVKTSVINNWSTIRVILPPTLQARYDQTQFALFIQRNLYAMSYIAIVSGLLMILLSFAAQSLREIMNVIKRRAAQDKRCALDPEVHPEFVARREWTLMFKSSKRNQRICMRVTCGFAAVLIVAITVVMTLSVIFTTQCASISKAHDVRSALLGSNTSAACSTIRLRNEYASGKLQVVAGTSDQGNATFEHNAVSSKYLTSSGFSTHQMGSTCVVDATPGDAPTFLWFDTSCQVANLLVALPALANTSSPRPAIEMSSNTSAIDINLLQNGTKVPVAGLTISTDQANVNIYGAAISSGGLSVVSTSGEVNISTIVVNATGPLGAKTPTTISSSLGSVVLTNSSLIDSPLSITTDVSGILIQSVATAVTHGHTSVELTSSTGGIVVSKLDADWVALKTSSGAIIADGLVSNGNGALVGRIDVQSIGGSVRLTNTAAQGYVHVETNSGNVVVQLASSTFSGLYYIRSEYGRVRVRTGNTTYDTITRFTTSDPREAQGLINCGTSCHYVGDLYIRTVYGDVDVQVGCASASYQLDKNIMRDDRRRALCRSKRRLKRLKRQQLRRFHLVAMEITDELIKRRSKHFDVACIQRLNLSSANIAKLALLDTCTSLVELNLSKNHIASIRGIPTLAALRVLDCSFNEISSLGITFFVSKFHEFIDDLALQPQLEELHVEGNEIKHVDFVKLQRQVPRLRRLFLHTSTAPRSNPGVVLLTVCKMDNYHAVIQAAMPSLEYLDGEILVLRQMATEAKSKPTPEQDADVEQAIQDATWEKVSWELPRTNAAFIMESTAKLRAMLADCNRDVDGDALDLLRQMQAALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X347</accession>
    <name>A0A6G0X347_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_009091</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prominin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000117">
        <property type="protein sequence ID" value="KAF0734230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X347"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020312"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008795">
        <property type="entry name" value="Prominin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22730">
        <property type="entry name" value="PROMININ PROM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22730:SF1">
        <property type="entry name" value="PROMININ-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026267806" evidence="8">
        <location>
            <begin position="19"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="436"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="471"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="756"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0734230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="793" mass="84263" checksum="DDCE3A78041ED55E" modified="2020-08-12" version="1">MRFKRLAVLAVAAGSVLATNLSSTTLCSPSTSKCVLLNSDSLSFVNQSQLSLDDSSAQTGVVGQAISYSKAATASLVAQVDSVRGYTQDWFHVSLKMMAIWACTSTLSAQDKQRCAPLGDPLAVMNGSQCLAVAGVGNCSSLGLCERQPNCYWPPPVDDRQPYFTGDMAAAATTWTNSGYVGTFVPYMIPGLFLALVTFVSTITFVILRCGFDGCYGSAPFKYGYSKCNKVAPAIIFVASSLVVVVVTAIAFTQNQTMSEGIVGAFQAMDITFANLNVMTQNVDGPLASIKQNLNTSVESIRQDLGTTTWVSSNFTMLSQVTTQWTASLQALGPFPSGCTLSSSSVCISCPSALCRTLPQSLNQWLAQLVTIRQSVDSSISTMRSSVASAEASISNSLQSASLLVDYVQLKAASSQTSLHSAWTTFKKIAKYRIEVILAIFILGLAVAFFGLIALCAGYRSNSSRWIKVMHVSWGLGAWVAFVGFIISSAMLVIAILGNDGCHYVLEIQKNVELIWPGQLAKVLDSCYAGQNPLNALDLSNDLSFSCSLPASLSNASQGTTALSSFQSFVAQMNGFSTASFGLSDSSTASLIAQAARSTPGLNATNIRTPWTIYGQSSAGSSCTNATTAPTCFMNGKCTTSACYADYVKAYSTVLATDQIVVKLRELKSDLAAASPIVHSSSWPSSLTSIQDVATQYTTALNSLSKGPIQRLQNGPMGSLLLDIDRVKCSMDCSWLVGATDLLYTSICTNLVGSTLSISLCVFLLCFFLLPMIVTAILLEKRLRGVPKAKLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X3B6</accession>
    <name>A0A6G0X3B6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_008865</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000114">
        <property type="protein sequence ID" value="KAF0734405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X3B6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020573"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
        <property type="entry name" value="FYVE_like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="272"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="355"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0734405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="394" mass="44293" checksum="3B96BA9D35DB9E5A" modified="2020-08-12" version="1">MSAKPLPPNFFHCPPLSRDEKQRFKEQGIAAAYELAENTQLKGGPIKWELDSNEHDLKIYMGKVAGTKYAAFSATPCLSTIEIMGTMTEVFDLFRSQTTEEAKDYCRRFGKVLEDAVNLYSIVPVTPETPHEMVGISWRGFKPSVDKLVMRRDACLLDVHHAFEFNGKHVWVRCLKSVALSCCPQLPGYVRMTHHCSGHIFSESDKPGYIDVSFIVHADAGGSVGDYASWIVDMTSRKRCRNLTDIDRFLRENRMSKTPFLKADKTKPVTLASSCYLCTRRFGPLSKKTNCLTCGEVCCRRCIRLWDVKNRGFDAQASVCTKCALGKPDNQKPSVWWRTSQSYTDESHFGSDGHTTPGSQGSTTSSPKRLDLFELAVDARVWSSKKQLQVTLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X3C6</accession>
    <name>A0A6G0X3C6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_008884</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000114">
        <property type="protein sequence ID" value="KAF0734424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X3C6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013655"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0734424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="128" mass="14561" checksum="EB4B1E17FB8E47BC" modified="2020-08-12" version="1">MSKLPNDFEFPAVDAATAWRLWLLGNAKKGYPPYRYIVPLDLSSSKQRKVLSDWKFVLGRFEFACLHVGLSIPDQPTEEDAVKLFEQVALYICAVCSSVPSKRIRRVTQLKLVSLIRTLRKAASNNDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X3N6</accession>
    <name>A0A6G0X3N6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator complex subunit 15 KIX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_008767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000111">
        <property type="protein sequence ID" value="KAF0734523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X3N6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010672"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="614"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="670"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="466"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="488"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="682"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="705"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="724"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0734523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="743" mass="79409" checksum="99068AF2807BABE2" modified="2020-08-12" version="1">MPEATTVQSVSQPTVGPPAKKARVRAPPKAAAAKAAPTLPPAKITVPAGNAKATTNTPETATPKGKRPPPTATAAAAAATAAAKKKQVQQQQQHAAQMSQMSMNGGAPQSSAATPNMNNQTTTPGNFGPNGNPSMNSNNTAGFPGGLQRTYSGMNMMGAAPNGTPGNGANGMSSATPPSTDPSAVPTLDPTMRRTAMQALYMRYKQLHGTKVDDTTLQRMAAKLEQQIAMKSSSREEYTINSQNEIKRIDLSQRMYGTPPQGSSSQPGDNPMGNMAKPNPSANSTPTSNASMGNFNVAQQQQMLQRQLSQNMLYGGGNDPAAAAAAMQQAAQMNGNPFQHAAAPGNLSYQEFCQRMRFQPMEKLIDVMWNQRLMIFQLQQENCAYKKQCGALQQMVMTMNMNMNNGGYNNMQPQQPQYPQQFNGMKAQSPMFNSAAVNYGMQQPGMDQGQLSRQASMNNMTPTGNFQQPQTPQPSFTSQLTGPPPSSATPTAVPPSASSAPTATPTPSNPAAAPANAAAYWAKVQELKEKHSDHLKKAYQILCMAAQSGSRQTSKAESMKQNIHYAIVVLNESPATAQPRENNVLQAIETFIVDSIVPLVRKVQEVSQSQQMAAAAANSASATKSEAPGQHQPPQSQAQQHQQQQQQQFLQQQQQQQPMGEFTKQLFDATAPTHNSQPPKPQQTAAGAAAGNAARSAPPPPPATETKDQEVEKKENQSALGNMDDFDDFDDLDDLDDDKLDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X4F1</accession>
    <name>A0A6G0X4F1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_008663</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000107">
        <property type="protein sequence ID" value="KAF0734705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X4F1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021157"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052108">
        <property type="entry name" value="MEGF/SIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24035:SF143">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24035">
        <property type="entry name" value="MULTIPLE EPIDERMAL GROWTH FACTOR-LIKE DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like" evidence="2">
        <location>
            <begin position="178"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0734705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="512" mass="53025" checksum="C93DCDF1A5829175" modified="2020-08-12" version="1">MTTGQVNEVQLLKCTASGFFFLKFKGVRSQAIPATASATQLQSILQRVRSIGAVKVTYSVGTTLCNSAASNVVSVEFRSSFGPQAPLIAVTLQNEQPTLTDGNVIVATGGAAVGTVVSVRGTKEYIPCSGRGYCNPKTGQCSCYTFPMPGYRSSDGYGNVGIRGDCGAPDNLNFYGGPIKGCPGYVPCSGHGACSGAPSFKCTCAVGWVSGDCSQRDCPKGQSWFSLPVSNNLAHTTWTTCSDGGICDPITGECACEAPFAGAACEIMQCPMGSDQARVCSGHGVCLSLSDLAEATTIGGVPAGYTYGAVANNPSTWDAAKIFGCKCDAQYIGHDCSQRKCPTGDDPLTLGQVNEVQQISCQANGGTFQIAFRGATSSPIAFNAPVARVQDAFLAIPTITDISITYSQQGGGACIGGNIMTITFTQDFGALPLLVIVDQALTLSGQSQQGKSIVSRIQAGTKENAVCSNHGTCNYNTGVCHCGFGFGSSNGYGQPGNRGDCGYVMPWQVVVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X4W0</accession>
    <name>A0A6G0X4W0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">COMM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_008419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000102">
        <property type="protein sequence ID" value="KAF0734942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X4W0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000151"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017920">
        <property type="entry name" value="COMM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07258">
        <property type="entry name" value="COMM_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COMM" evidence="1">
        <location>
            <begin position="100"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0734942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="184" mass="20757" checksum="18C01DDEC681F693" modified="2020-08-12" version="1">MEKLLLSCETSAQVDEILERSFSIMLHGSNIKDLHLDIAQKELQCIVTAAMSPDDSPYLSDTLALMVQNAKLQGLLGELLHSARRQLWRDIATRSESFPSPPQLLDVAWLVDMPVAADTNQKRDPTAHVDLTIQNMPNRVDVFPPLRHIAFKLDRDALDSIVHELHNVRDQIQRLHNTTESAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X4W9</accession>
    <name>A0A6G0X4W9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_008429</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000102">
        <property type="protein sequence ID" value="KAF0734952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X4W9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000164"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00106">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF75">
        <property type="entry name" value="CENTROMERE-ASSOCIATED PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4 5 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="60"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="444"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="386"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="566"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="460"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="142"/>
            <end position="149"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0734952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="633" mass="71038" checksum="678B88CB5E9043E2" modified="2020-08-12" version="1">MSAPCCGQTWSDSKVPHFCNLMDEANKIPTAPAETKIHKSSLSTVSGTANTPSRKGQSENIQVFIRIRPLIDRETGLDPAAQHFIRATSDQTIEVQTSESNIKCKYDAVFGPSVSQDDVYDRVKDCTDAFLNGFNSTLFAYGQTGSGKSFTMFGAESDLSRFRPGLAKSQAGIIPRAIKDIFAGLITMNASGKQQSALFCSFVQIYNENIYDLLRDVNMDRPLAIHEDRMNGIYVEGLSEYAVQNVHDCLSLLQAGEENRAVRSTHMNQVSSRSHSAFQLFLETKRKDGTTIKSKFNLVDLAGSEKWHPDANMQTNNHVPYRDSKLTRLLQDSLGGNTKTRIIATLSPAVDCIEESISTLKFADRAKQVMVCVRVNEQREIDPAYVEKLEQEVADLRAIVSSLDQNSSPNSETEANKTGESQLVRLLKENADLKEQNMKLRRQLDEQPTRACPIRPSDASPVSSTIEDGNRCSNQNHQALETIIMRLKDASERFFKFEIEEDELKDIMETSFKLIHQKGGAPITPLGRPSLGFSRPQAKAKSAEVAFRVRGKANQADSWQTDAPQKKSEEDEIKAAEKAMKKQAKLQAWLLEKERRELAKLQQQHEYIDEQRKAQAEKDAKFYKRALETKKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X4Z7</accession>
    <name>A0A6G0X4Z7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_008270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000101">
        <property type="protein sequence ID" value="KAF0735055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X4Z7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010528"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031397">
        <property type="term" value="P:negative regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030178">
        <property type="term" value="P:negative regulation of Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46472">
        <property type="entry name" value="NUCLEOREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46472:SF1">
        <property type="entry name" value="NUCLEOREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13905">
        <property type="entry name" value="Thioredoxin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="172"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0735055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="324" mass="36207" checksum="B21B26177EF09F5B" modified="2020-08-12" version="1">MRPILLDFDESTVTIFWANQGSAYDVQWKKAQDADWTPLSLKSSLMKKKNIEAGTTYHFRVKSTDATTFDEPLEWTHPSASQQPSAPSVVMEIMPNDVQLLSATVQWTPNGSTSPPPYEVQFLAMDGVSDWVTATATASSTAIKKKNLPNQASPYAFRWRSALSTLWSRTACPILPPAPATALSRAIAPTLVSNNGTSVSSASLGGKVIGLYFSAHWCPPCRQFTPMLAQFYNTMKQLGKPFEIVFVSADQSQDEFNGYFRDMPWLAVRYDSNERKEIEARHRVESIPTLKILNAQGTIIDPDGRQRALQQTTFDQWYARCYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X5E4</accession>
    <name>A0A6G0X5E4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ZNF598/HEL2 PAH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_008320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000101">
        <property type="protein sequence ID" value="KAF0735107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X5E4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017033"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057634">
        <property type="entry name" value="PAH_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044288">
        <property type="entry name" value="ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938">
        <property type="entry name" value="ZINC FINGER PROTEIN 598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23202">
        <property type="entry name" value="PAH_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZNF598/HEL2 PAH" evidence="2">
        <location>
            <begin position="329"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0735107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="490" mass="55229" checksum="72EDF38DC739F198" modified="2020-08-12" version="1">MQQQRPVERLLRLDVSVNSFRFINKTPEFQIGCRAECATTKELVSVEWVVYKSFEECQVFDTRIRASQAAQYMANIPFAPLYKTKTFFGQAMKPAFLATRQRDLQEYFNRVTSIPGITQFQTREGSLALADFLNVHARLLIEQQPLVDVSRTEDAPQLRSLTSNSNVSQPDEPSLGTPRSSDESDEVHLTEAQQQELQALIMERISEHAGADVLKAFQKRARRFGKAVDAIDVEGADFYSFMVESFGVEFCQWLVPSLATLLPDKRKRQALTAAVTSTSPQSIDAIASNRSMTRSLSRVRPASEAAIPSTRMTRPQRSRPQSANYTNAKEVMAKVRDLVGDDEERVEEFRFMTKELRARRTSAAEYSEYVVNTFGTDVSKDVLVSVAGAMADNQIQEDLHAASEHVHSLRGSIQRQRSYARRKSLDRLSQSSFKSQTSLRSRGYSIDEEEGYVPSHGSSGHTSVEEEPPQDNKILSRLRNQGAVNLMSFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X5K3</accession>
    <name>A0A6G0X5K3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_008158</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000100">
        <property type="protein sequence ID" value="KAF0735241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X5K3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006485"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0735241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="273" mass="30812" checksum="1DB79EC8FB0AB529" modified="2020-08-12" version="1">MMQVPEHKGQCWTTTLFSWPYFVLMWNLMSRSDSIDSIMLQHIDWQDDALIIEEQGHKGDQSGADKYGKHVYANPYQPHICPILSLAVLLFTFPSRTKLDQQLFYGPDSKNGFGKILRRVLDSMSMSDTQFLGCPAVDIGAHSLRKGSTYALSHCNGPNPVSVFIRMGQSLGKLKDRYIHFGEGTDQLCGRMISGLPFIDEKFGVLAPHFPPSILCRLDDNFWSEIVPGFSNYPPGVQSAFPFFLASIFYHESFLRSNLAASHPIFNSKNLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X5T6</accession>
    <name>A0A6G0X5T6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerase II subunit RPB9-like zinc ribbon domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_008150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000100">
        <property type="protein sequence ID" value="KAF0735233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X5T6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002817"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001193">
        <property type="term" value="P:maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase II subunit RPB9-like zinc ribbon" evidence="2">
        <location>
            <begin position="10"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0735233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="129" mass="14866" checksum="E4A76DA82BBC0D8F" modified="2020-08-12" version="1">MAFLTISSSNNMLYPSQDRELKRLTFTCRNCGHNEEVPESCIYVNKLVKDARNQMDILPDDIIDDPTLQRDYDVTCPVCGGQGAAFIRSHDGVKQSTLALIWICLNKDCQIDDHGNRLPTHRWMEEMYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X759</accession>
    <name>A0A6G0X759_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_007816</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000093">
        <property type="protein sequence ID" value="KAF0735811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X759"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002070"/>
    <dbReference type="OrthoDB" id="79081at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="18"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="151"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0735811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="257" mass="29491" checksum="42908FAA708D3D49" modified="2020-08-12" version="1">MAFEGIRRHSTSGMLTQADILRVQNQVLEAKVLELTEELTKTQYELRLERVNYRHLHKKSLSLQNQLEAQGNLILDLEQRLATANAQLHAQPEPTTLQPLCDEHLNMLHEDIAMYQARCSLYEDAIRELWRTYVMPKTDDEPPIVEKKLQDDDDSDDTMSMDSDCEGQEEEEVPSWMLMEHLCAAISESVEMHQEYLAAISDMEEQLAYDSQQHWNMTKTTTDDDEEPSSSSLEADDSAFTEIISDLHRLLSVAACS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X9G2</accession>
    <name>A0A6G0X9G2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RCC1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_007061</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000088">
        <property type="protein sequence ID" value="KAF0736611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X9G2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018284"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051625">
        <property type="entry name" value="Signaling_Regulatory_Domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872">
        <property type="entry name" value="BTK-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872:SF2">
        <property type="entry name" value="INHIBITOR OF BRUTON TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="32"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="66"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="RCC1-like" evidence="5">
        <location>
            <begin position="124"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="131"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="184"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="235"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="291"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="429"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="470"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="670"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="922"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="673"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="706"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="771"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="808"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0736611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="946" mass="103623" checksum="354FF5EC8E9EACEE" modified="2020-08-12" version="1">MDIWKAAHDNDFGAVEYLLKEGEVPVDERNSIGETALHVAASRGFDNVVDLLLRHGADPNAQDKESGYTPLHRSFLHGHLNASLLLLNGGAMLSADESPQCVLDNDGLSPLDLLSTRLERDKSSTASATGGEIYTFGKVDFQLGYHLPHGDEQYIPRRVKFPPGVDLVGVSAAMYHTLAVSSTGQCYSWGFGKGGRLGTGSEFNCIHPVQLHFPLRVVVKASAGENHSLALTSNGHVYSWGSNSFGQLGFPVKTTNASSRLSPKRIDAFKGVVIVDIAAASSHSAAITSSGHVFTWGSNKKGQLGRKEGFGTDQALPTPKRVDSLLPHNANPAVTGEYTSVVATKIAVSCHHTCVILRVQRDLCDQGQVWQWGWGAFFPSQVILRHHSREEKLRQQHQNIWLPRAQQYPISIVDISCAPLHSIGLSSLGNVYTWGHGPNPLGGLNYVPLHDRATSVAAAKEHCAVVLQSGDVYTWGCGTLGHEGRNWQPIPKRVARVKQATGVVAGPQHTAVLVAPRRPSVECGHDTLLDQCQHVLREQVTLQSVIKLFAKADMLDMIPLQEMCRQFVAQNLDAVLEMTKNVEEWPIELDEVGTERQLLLQAQEEAAPVVKASTAVTEIPIKKDIEKKLRSLRKRVDQLNDLELLVSLNDSQKAKLKRKPDLQRQIQELSAQLPPPPPAPPAAEKPNEAKTRTPETSQPKASRRASNAEKKNKVEVKRNEPPKNEVEEVKPSPSPSLTAKPAPEPKAPKGKAKFVPLDSFLAQSKPPTPLLKPTTPLTKPLVPSTPPLSWVSPSLKPQMPPPMKLSQSPSMAPASAPLVGSGQSFSLECFMKPSRKSKAMAVVEEKKSWNVVAPAAAHSLTAIQAAEAIQVKQTWNLRENKWGLCQSENVNLADIQSIEMREKQEMEELIRQDNELAKKLQAEEFERAKRQQKRRAKGNRSTVRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XA90</accession>
    <name>A0A6G0XA90_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Deacetylase sirtuin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_006819</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000085">
        <property type="protein sequence ID" value="KAF0737008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XA90"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005163"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF6">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0737008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="316" mass="34717" checksum="9CD994E56C8FFC57" modified="2020-08-12" version="1">MSKLASIVESLRHGNIQRVVVLIGAGVSTASGIPDFRSPGGMYDTLRPELLTATVDEKAWLCFDPTGVVSWDLFQYNPFLYLEVRRPFILGTANQSWKPTIAHAFLQLLNDKGLLQRVYSQNIDGLVHQLTIPRDRIVDVHGTLHKVMCEYCQNDGGYTLESFCDTVRTKIKNIYDPQDGPAASSAIPCHTCCRASVKPATVLYDRGLPKEFAINSATDLPACDLLIVAGTSLTVYPAAGLVAEVRPNVPRLVVNLEPVGEELGIDYSDNSHQDAFLQEECDAGFLHLATELGWLDELRQLSPYLCDKSQALLAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XAT5</accession>
    <name>A0A6G0XAT5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_006443</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XAT5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011169"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040235">
        <property type="entry name" value="Nicolin-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31239">
        <property type="entry name" value="NICOLIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31239:SF2">
        <property type="entry name" value="NICOLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0737269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="201" mass="22978" checksum="A00915FB34F166FA" modified="2020-08-12" version="1">MLKEFTKLVVSKVEDANHEGASQSEDKPPGQHTHRIEVIFRSPPSNLSHITFQNYYVASLRIDQVINGRSDVILEKRSLMDDAHHEDDAQNWHIIKREELGSHFDSTSVEKLIFYLTQPSPLWEKWELRTLKVFETSEAIEVVPKALLAEKATTESSMHMYRKYTVNTSGVALDSKDISGHATRFMSLLALLQSKVTKEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XAU6</accession>
    <name>A0A6G0XAU6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_006389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XAU6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011843"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF63">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="103"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="236"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="438"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="892"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1065"/>
            <end position="1099"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0737210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1217" mass="140985" checksum="9FB58F8DA75D754D" modified="2020-08-12" version="1">MDGDGDAVELKLQQNLLKQHENYARQKELLQKLKMQSEATARNLSFQQTHDAPKASPVLHSRSRIAFDDVKISSPRPSLLMDLAKDDQCVNDMHSQELVNDGLRKQLELIRRLESENTRLRSDASALRTQVALLEDRSKLKESEMGRQASELENTASELLNLRHEYNDLLQRYQQSKQSLNKITRVKDTLEEELRAALESQRRLHERANQFESDLDDAHSREQALVAQKKALETGQTHAQTTIQALQDEVQHLQDALANKTDQCTAIQTSASSCVENIEANLSAVQEALAKEQEKRRTWETAAHSLEAELDQLKSLHAASRQAMETVRELRDRNAMLEEKVPYYEQLELDNKEIHAKLLMAQRDREEHERLVIQMKQGIWTTTNVLKKEFEAMRSYLVSIEDEGIVLEDVDVQVTSWHECPSDIQHLRSVLHHFKHDLVHLSKRMMESREKEKALKNEGSQLQQKLVEVRHDLKELERQLEVQKEAYAIAESAREISSREKRDLLLWSRSTCQKTERMANEVEQWEQFTIQQIHRMHRLPWQETSVHVVEPKYSSYAELRSSWEQALQNVFQEAHQCHVKCNQETHRANKETKRKLELQRRLDLNETESQKKCSEKETELQAIQLRHATSLQTLQEQHRVLLRENDTQIAALTRQVEDLTMKWNASEHDRQILKDQNSILESQAPLYTGIAHLFIVCVRPMVLQISELQIQKRILSHQINQLQGQQKEMEQIAALFHNIEGEKAPRVTFRAAALAVFASNRFRNMSRQYGRNEALGLVFPQQIGVIKLLPMSSIQYSSKALRRLQQNDFVEKWTALAQSQTITTGVPRRHGIYGHSSLGELVLSTLTAIDPTGECVLSNTLQGHSSFLCDLHPVRSNRKQTTLDVHSIRREVVEWMKKVDNLQFQRTELQKENYSLQSQIHDKDYQLKEMEVLSANAQELQEKLNMYQTHEGHAITVREFEASIAACREAEARCEEYVAEIAEKQSLVKELQTQLDTTTNRNKMIEEQLDSTRKALLDEEEAVVSLKSVVSRYEAEMRKLTLAAQSVHSQFQQRCNESEHDKQELHALSALLQETRKKNQTLEDELDQMQQEMKAKSSVHASRSRLGSEHSIRQSEVYSPRLLRRSAVHDNSMHTSKSQHAAIEYKDLPHKLKASHASSYRDKMHVADLDSNEDVSMDIEKVNQDVHNYMDRIDKKLEKIYGIPGSSKWKDYNFSDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XBT5</accession>
    <name>A0A6G0XBT5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_006634</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XBT5"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0737474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="90" mass="9981" checksum="767B0D99E20BF85A" modified="2020-08-12" version="1">MGTTRMQSSRPDDVVDFVLRNRDMASLIFAFQDGFPQDIIRLKQAVDLPAFARPPRRFISSSGAFEVFAAKAFGTAFKNSMQCVSFGSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XC74</accession>
    <name>A0A6G0XC74_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_006363</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000083">
        <property type="protein sequence ID" value="KAF0737699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XC74"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021026"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000009">
        <property type="entry name" value="Probable E3 ubiquitin-protein ligase HECTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF440">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NEDD-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="11">
        <location>
            <begin position="308"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="9">
        <location>
            <position position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0737699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="642" mass="72864" checksum="ED54D071E3F4BA8E" modified="2020-08-12" version="1">MTNQDFVIALSIVVILLAFTLFGLIRMILSQKPMPGMRMDMAAYYNRPLLEEDFLGALYGLNRNDIEELMSEVKKWPCGVCAFANIPESHACALCETKQGVVVSETEEGPEFIHPKNFTPLQLGARTRKQWVRTVNESTGRIDWKQDAQHATSRDVFFVVTSTLPSIEEECLYGERQDDDRVEVVVDDPTLSQSATEHSKSKEEEVLELRMSREEASTVSVGVSKQPLQIELAFTPLSKDSASRTLMATNLPEWLVQHLEHITKEPFSTKYLALLSLLKSNIAFGYSKFKVYREKIFEESIGVLQILGPLHLCTRTRIELIGELGVDAGGLQREWYTILTQAVFEPSAGLFVSTDSYDYTINPMSTSPTHLRMYRAIGRLLARSVLDEQVLPFHFCAPLFKMILGTPISMTDMLYMDKQIYQSLQFISTTPDVENLCLDFSVTLPSGEVVELVPNGNNIMVTRANQAEYVERMLQYLLFDRIQPQLQSLLTGLLEILPQHYLMMFDHKELELVLCGVTEIDMDDWKQFTASSSTLREGGDHEDKMEWFWDILTHMSFQDRAKFLQFATGSSRVPVQGFKGLTSYDGRLCPFSVKAIPYERGILPRAHACFNRIDLPLYPTKALMTEAMTAVVQMGMSEFTIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XCW8</accession>
    <name>A0A6G0XCW8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_005904</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a long chain fatty alcohol + a fatty acyl-CoA = a long-chain alcohol wax ester + CoA</text>
            <dbReference type="Rhea" id="RHEA:38443"/>
            <dbReference type="ChEBI" id="CHEBI:17135"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:77636"/>
            <dbReference type="ChEBI" id="CHEBI:235323"/>
            <dbReference type="EC" id="2.3.1.75"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the long-chain O-acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0737907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XCW8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003695"/>
    <dbReference type="UniPathway" id="UPA00282"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047196">
        <property type="term" value="F:long-chain-alcohol O-fatty-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045034">
        <property type="entry name" value="O-acyltransferase_WSD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009721">
        <property type="entry name" value="O-acyltransferase_WSD1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004255">
        <property type="entry name" value="O-acyltransferase_WSD1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31650">
        <property type="entry name" value="O-ACYLTRANSFERASE (WSD1-LIKE) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31650:SF1">
        <property type="entry name" value="WAX ESTER SYNTHASE_DIACYLGLYCEROL ACYLTRANSFERASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06974">
        <property type="entry name" value="WS_DGAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03007">
        <property type="entry name" value="WS_DGAT_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="O-acyltransferase WSD1-like N-terminal" evidence="9">
        <location>
            <begin position="95"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="O-acyltransferase WSD1 C-terminal" evidence="10">
        <location>
            <begin position="313"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0737907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="462" mass="51893" checksum="EA2DCA55787F58D9" modified="2020-08-12" version="1">MGQESASAMIALALSTLLVLLAYLRLRRPSSFFRSIGTVTLLTEDEIHLSIMTILMVVDGCWSHGNVVGLIRKRMAEDKLFFWRFCSTVNSDGEFEADVSFDPAMHIHAVNLDDSITPLEFAEQMSAMPLGRAHPLWHCYVISPRGKDANTTHLLWRIHHSIGDGASVNAFFVRLSDSKIPPPMVRVPRYQAPSWLKRLKLIIWSLWLYLCKWWQFMTRPEPSTCLKPSNGGKRRKRLFYTTHYSVKETKQLARRLGMEATVNDIFVSCITGALRTMLLLDQPDMNLRSSFILRAGIPVDMRPWSEPINAPDNQFSCLLVDLPVGEASPLDRTKRVIASMKQAKGSLERQMTYAISLAIAQLPRWLLPRAIRFITSHSSVAISNVRGPPNVLHFSGHALLSLNGYVPPPPNVHLGVAIYSMGDALGISVQVDSGIFSQPERFLKCIQDEYFALQQLASPPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XD37</accession>
    <name>A0A6G0XD37_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_006067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0738076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XD37"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015487"/>
    <dbReference type="OrthoDB" id="406368at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010736">
        <property type="entry name" value="SHIPPO-rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40429">
        <property type="entry name" value="FLAGELLAR ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40429:SF1">
        <property type="entry name" value="FLAGELLAR ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07004">
        <property type="entry name" value="SHIPPO-rpt"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0738076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="292" mass="30114" checksum="3664AE165795CA30" modified="2020-08-12" version="1">MSSSPTRASPAKPSTARAGSPNRGGGSPSRAAFALNTAYDDIKSSCGEQVDSRKRTAPTTCFGTSSRPKDPGDGNKSPGPGAYQVPTTIGKPVVSTIRSAPACSISGREKFGSTSDLKLAASCPGPGDYTPHIVNPNERNAPQFSLGKKWTKGIVDSSAKSPGPGAYDTPESLLNTRTVLSTSKHATASSFPKDNRKPLLDTSSADVGPGQYDTGNVAVGKQVVSTVTNSAAYSFSVVGRSKAPVGARMSHDASPAPNAYKHKDAVGTQVLSTYKSAPKCSMSGRTKFGSHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XF14</accession>
    <name>A0A6G0XF14_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_005544</name>
        <name evidence="8" type="ORF">Ae201684_005545</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000071">
        <property type="protein sequence ID" value="KAF0738616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VJMJ01000071">
        <property type="protein sequence ID" value="KAF0738617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XF14"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021883"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008506">
        <property type="term" value="F:sucrose:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432:SF26">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13347">
        <property type="entry name" value="MFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="452"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0738616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0738617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="481" mass="52440" checksum="F8D4B587ED09DDBD" modified="2020-08-12" version="1">MATHVQDPAIPVTPNDVDYVQKDADGLDVVDKSQQEGMSVPMMFLVCCPKMAMNMAWAAQWAALGPLLQVLLSYSSVQGVQLVGPTAGLLVAPTIGVLSDTTTSKFGRRKPWLFWGAITSIACWAVMMNAQDIGESLGDKGDDRTWTTVFVVICYVWMDITCNLTQVPVVLLIADLAGNRQVTAASIGQVWSIAGSFVVSGYIMFFGPAHQSIKPFMGMLMGIMFVTCMSVCWFVKEEQYIPAVKPDTKKQLKDAFSALWVGFKKLPKVLLIYCLIFLLLQYGYTAYNGAKGQFFGIRVKDGLAENADKCGKEGQPECTQRQKDYNDGVRLAGGVTDTVFNLFGVAYLAIMPFLVRKIGAKWVIVIACIPQALLIIMSFCKVVAIDMILVILTSISQQTIFALQLPMIVYQIGLAPDNDLGMYAGAFNSANCAGQFLNFALATQLVKTSMTFALPVLVGGILSAIALLVAIFFLKLDMKTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XF45</accession>
    <name>A0A6G0XF45_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphate acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Phosphotransacetylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_005439</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 2/2.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.8" evidence="2"/>
    <dbReference type="EMBL" id="VJMJ01000070">
        <property type="protein sequence ID" value="KAF0738828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XF45"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016809"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008959">
        <property type="term" value="F:phosphate acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03109">
        <property type="entry name" value="DTBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.20">
        <property type="entry name" value="HprK N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10750">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010766">
        <property type="entry name" value="DRTGG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004614">
        <property type="entry name" value="P_AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042113">
        <property type="entry name" value="P_AcTrfase_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042112">
        <property type="entry name" value="P_AcTrfase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050500">
        <property type="entry name" value="Phos_Acetyltrans/Butyryltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002505">
        <property type="entry name" value="PTA_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028979">
        <property type="entry name" value="Ser_kin/Pase_Hpr-like_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004167">
        <property type="entry name" value="PRK05632.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007233">
        <property type="entry name" value="PRK09653.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00651">
        <property type="entry name" value="pta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43356">
        <property type="entry name" value="PHOSPHATE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43356:SF3">
        <property type="entry name" value="PHOSPHATE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13500">
        <property type="entry name" value="AAA_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07085">
        <property type="entry name" value="DRTGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01515">
        <property type="entry name" value="PTA_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75138">
        <property type="entry name" value="HprK N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DRTGG" evidence="8">
        <location>
            <begin position="268"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphate acetyl/butaryl transferase" evidence="7">
        <location>
            <begin position="435"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0738828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="767" mass="83182" checksum="F2C562C97E2CE9CA" modified="2020-08-12" version="1">MLRVRPFLSVQRSAAFALAPRAATARLFSETPKSNDRVIVMTNGSTAKHSHVLLGLINKLSYTFPSVGYFRPVGPNLHSAHGDHHVDLLRSEFQLKDEPELLVGLTQDDVTRAHLKGDTDSVIETMLTKFENIRAKHDFVVMEGAVLDSSPELAWELNVDIAKSLNAPVLLTVDAEDIASDKSLNWGADEAAKWLADQICTRVLLAKEMADTAGLTHVGTIVNRVKTGDSIALRQLVQDQMKDRGFDPTKLLGILPVDPVLDSKRLNEVVGQLRAKQLYGAPMSNSVVVTDGLLATTELNDLFGHINKHDDGLLVIVSAERTDVILGLVASRLSGALPQISAIILTNGGVPESECRKILEGLAKLGSSPVPIYSVEEDSYRTAIALSKVTCGILPTSQKKISRAFILFDENVESNKLLGQLETNVGSAKTPKQFKHFLFEASRAADKHIVLTEGEDDRILQAADEVLRRGIARLTILGDVEDINSRAKTLRLDLSKATILNPSTADRLAVYADQYYEKRKSKGITPELAKETVSESTYFGTMMVDMNDADGMVSGVCHTTANTIRPALQLIKTRPDRPLVSSVFFMCLENGVVLYGDCAVNTDPTAEQLAHIAVQSAESAKAFDIEPRVALLSYATGDSNKGPIIDKVREATRLAQSFAPDVAIYGPIQYDAARNPSIAKQKVKGLKESEMEVAGHANVLVFPDLNTGNNTYKAVQQATDCLAIGPMLQGLNKPVNDLSRGATVGDIITTIALTAIQAKQIEKKPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XFV3</accession>
    <name>A0A6G0XFV3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_005251</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000067">
        <property type="protein sequence ID" value="KAF0739071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XFV3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013349"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="366"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="445"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="537"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="537"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="550"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0739071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="567" mass="61581" checksum="671C4EFA25F1F5F3" modified="2020-08-12" version="1">MGCLAVHIPQLSRLCVWTNPMQAERTKLVQTLPTVATKRGAPTFPPLEPGDDNEPLSQDVLEVTTMAAQISLRSLVRQALLVTDLAYVGHVGTKQLAGVALAHAWMGLPSAFVQFSIQAISTLCSQAHGAGNPHLVGVWLQTALVFAMLSAIPVTIWYIFVGEMVALTMSDADTLAFAAEFACIMTLGLLPQYVYAALVAYFAAQDVVMPATVISVITMGMNILFNQVFIHGVNGWHGLGFIGSPLAAVTSSFFQLALFVLYTIVWKKHHAPSWGGWSSDCISKTRLDVFFEHALPSGASAVVDWATITVASTFSGYLGPEMTAALAVMTGFFGVVTASVSGFTAATQIRTSRYLSRGGVTNAIRVCYIGAAIVLAMAVVWLLILVSFLEPFFHLWTNDDAIVSLGADATPPFLASMFIACVRFLLTACVNAVSKADLNFMANNVASWLIFIPLSYMLPIGAQWGIRGFWWADAIGEFVKTAILLRGLSHVNWPFAAREAQRAAERSNSIRSEENETREVNTIKVEMMFLTPRSFNSPSYDFSTTPRTPKAFRRPKNRSRSAANPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XFW9</accession>
    <name>A0A6G0XFW9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rab8 family GTPase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_005241</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000067">
        <property type="protein sequence ID" value="KAF0739059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XFW9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013358"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001129">
        <property type="entry name" value="ras-related protein Rab-44 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="44"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="216"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="254"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0739059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="464" mass="50806" checksum="A94C8101765F7404" modified="2020-08-12" version="1">MSDLDVADAAAQDAWEKEMEMMLDHRDSRSRSRSFIEIPTTPVQTDMPRTQSLGPLGFRTRSWTTQGEEGGGEYDSDMDIARQAAVSTKLYLVGSAPVDVEAIALQNAQGSASRNPTQHIEAGPLSAKTLDILSQGLVMCTDEADRRSMTEEELEEKKMAEEEAIKLQKEREIAPIEQVVDVAAPVKKKGPLGKAFSGFKTKVFGGSKKAAAAATASSASASGGNRNSITSAIGTARPPGPRIPRRASASSMPEYKEAEGDQVKRKPHKVKLLLLGDSGVGKTSLMRVFAGDDFSESMLATAGVDFKLRNLRLENEYDVALQIWDTAGQERFHRITSTYYKGANGIILVYDVSDKRGFDNVGYWMKNIQEHSQSNMPAMLLVGNKIDLPTRVVHTDEGQAAANMYHCRFMETSAKTSQNTSDALETIARDALIMTINTSMTQKELLEREQRLDGKLNKENCAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XFX4</accession>
    <name>A0A6G0XFX4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Multidrug resistance-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ae201684_005114</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000066">
        <property type="protein sequence ID" value="KAF0739189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010474"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000997">
        <property type="entry name" value="Multidrug resistance-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000074">
        <property type="entry name" value="Multidrug resistance-associated protein 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="721"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="764"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="845"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="105"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="422"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="725"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1050"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="652"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF0739189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1284" mass="139278" checksum="FA75D4C109C85176" modified="2020-08-12" version="1">MATPDAKYADLESPGPGAPSRLPQDEPNPMGSANWLAVGLMFWLDPLIRRGASTTLSEQDVWRLAPEDTSAALHRRFASFWALETALESPRFERALVKTLWARTAWATVMFVVYSAVMLVQPLVVQSLLQFILGKESPILDFSGYTLAAFLTTLSFVSVTLVDFAQAIVAQCGCNAKTLAMEVVFSKALKLPRRSNVSSGDIVTLASVDATRVFDLYIWGPWVVVAPCTLLAIFIILSFKLDWVAGLVGGVVMAGVLIYCFLAAKTVGKLRRELAAVQSERVKLTNELLQGVRVVKLYAWESFVIAKLDEIRATELELLRRFQYNSRLPAATLQASAVAVFALCLLVYVARGHTLTPDVAFSTMAFLGVARLPCTLFCAGVINCSESLASCARLASFLLEAEVEQQPALPPPQPSQPAAPLIQMDDAMFSWEADPSKLTLRHLSFAVESNSLTIVVGPVGSGKSSLLSAILGEIHQVQGTRHVGGKIAYASQDPWIQHASLQDNILFYNPLDEARYNQVVAACQLAPDVAILPQGHATEIGERGINLSGGQKARVSLARAVYRAPQADIFLLDDPLSALDVHVAGGVFRECIQTLLRSKAVVLVLNSHYHLLRHADRILVLDEDGSLVGNGTLDSLKEQFPHLVSLSVPEEVKVDEEAPSPPENDKAAPTTSPALPVASLTAATGPNLSRQKLIAKEERQQGGVSVSTYLTFFQASGWSGVGAAVAIALIFAGSQALLVSADWFLGHWSRSALASSGDRLHSAWIYFALAVCAVVSVFGACLFVVHLCLRCSKSLHASVLNRVLQAAIPTFFDVTPVGRILNRFASDLDQLDNLLPWIGMMQAQYVFQIAAVLLVCGITAPFIVLVYLPLVYVFYHIQRFFNVSTAQLKRMESTTKSPVVNLITEILSGLSTIRAMDMTDTFVLRSRAALDHHQTYFTVHFMASRWLQMRLDWLSAVIITGVSFLVVASKDSIGVTAAGLALTYASQLSSVLSRTVQGHAKLESIMTCAERLHEYESLQAEGSSSTGGENDVQVVQTDLTAWPSAGAISFQAYSMRYRDGLDLVLHDMSFSVRGGEKVGICGRTGSGKSSLVAALCRIVEAASGSIQIDGLDIAAIDLHVLRSRLTVIPQDPVLFSGSLRFNLDPAGAFASSDAELWHVLKQVHLADIGLDFEVAERGSNLSVGQRQLVCIGRALLRQSRIVVLDEATASIDVETDRILQETIRSSFQGVSVLTIAHRLETILDNDRVLVLDAGRVREFDAPQKLLEDPTSAFALLMQQAARGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XG62</accession>
    <name>A0A6G0XG62_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_005156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000066">
        <property type="protein sequence ID" value="KAF0739237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XG62"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010078"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0739237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="106" mass="12304" checksum="515FB041F722A443" modified="2020-08-12" version="1">MQCDSSEEGCASADALVARRRYFQVKQREYRRRVKDERTRLREELARLQKKVNNRQVDRGMLSWDIVASVFQEASGLSCWKSVPSGADESEAVRPQSSFQECIEWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XG69</accession>
    <name>A0A6G0XG69_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WRKY19-like zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_005275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000067">
        <property type="protein sequence ID" value="KAF0739095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XG69"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016000"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056866">
        <property type="entry name" value="Znf_WRKY19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827:SF1">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24906">
        <property type="entry name" value="Zf_WRKY19"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WRKY19-like zinc finger" evidence="2">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="WRKY19-like zinc finger" evidence="2">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="WRKY19-like zinc finger" evidence="2">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="WRKY19-like zinc finger" evidence="2">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="WRKY19-like zinc finger" evidence="2">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0739095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="357" mass="38453" checksum="52703BA1215F759B" modified="2020-08-12" version="1">MEYSFQIHPEAVNMSDHIVNDEMNLLWDSTVVPPIAPLPVAAPPPIKLFHEPKVTMIPTIPHTFPKESLEPMAFNPLHVNQILTHFPELHPMDGTFLRSAFENIETLPSNHPPRGQLQKEIPDVHSAPVSVEVLSPQSKDTRPAVRPSVGTTTTTTGGKQIICQVPNCGRRVRSKGFCKAHGGGRKCILPGCNKSAQNGDYCIGHGGGKECSHPGCAKAAQSHGLCKAHGGGARCKHPNCMKSSQGGGYCRAHGGGKRCQAPNCTKGAQRGNFCATHGGFRNCQVTGCVRTDRGGGYCEVHRRDKLCTAKGCKKLSKNNGLCTLHLRRSEKEGKRPTPITSTSTSYLLPATMTIGTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XGM1</accession>
    <name>A0A6G0XGM1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Multidrug resistance-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ae201684_004934</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000064">
        <property type="protein sequence ID" value="KAF0739365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008863"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000003">
        <property type="entry name" value="ABC transporter C family member 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000063">
        <property type="entry name" value="Multidrug resistance protein ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000610">
        <property type="entry name" value="Multidrug resistance-associated ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000997">
        <property type="entry name" value="Multidrug resistance-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="312"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="715"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="771"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="842"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="867"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="960"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="986"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="95"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="420"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="726"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1047"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF0739365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1292" mass="142591" checksum="E51361AFE79983C9" modified="2020-08-12" version="1">MAAKVMAYQSIPSSPQKRKATHNPTEDSSFSSRLFFAWARPLLRVGNDRPLHKDDLWPVESKTKCQHVSETFEASFHTTKSIPKSIVYVFGRELAASTLLQAVNVVSTVAGPIAIKQVLAAMESSDSFDLVATSQLIAVFFGLRAAAALSNAHANFWTQMVAINVTTALQHLLFHKTLRLSVASRRDKTAGEIANMFSGDVQTLIKFATYSNNVILAPLQILITLYLLYGVLGWASFVALGVILLGVVGNMLAYRNVHKTYDRIAQARDARMKSINEVFGAMQTIKMNSWEDKFIDKINGERTVELNGLKTFAHIAATAVVVMYLGPALVSIASFGTYTLVLQEPLPASKLFTALSLFSVIRQPMYQLPQVAMRMAQALVAFKRFKTFLDLPEQDFERVMTPSTADIDTLMVYRDGEIAVAMENATIGWDDKQPLFENVNLTIKRGEFVVVHGSVGEGKSSLCSALLGEMDKLSGRIFVDGRLAYFSQQSWIQNMTIRENILFGKPYDRVKYNRVIEACALTADLAQFPANDRTEIGQKGVNLSGGQKARISLARACYSDADIFILDSPLSAVDAIVQNEIFTKCFLGLLRNKTIVLVTHSPEIIESKFMDGTIEVKGGMLIQTKVDREDHPILIEPLCDAFGKRDPSLADISTSAALESNDIILSPTLTFAGPLFTPLPSTTRVQMFNETKSGQFVDDEESASGKISNKVYKSYFNAVGGWPTLIGIVVANCVWQGLMLTSDLWLNRWSSTAAFTTPQEFTQQSCFYLGVYAALAIIAVFSSFAQCVTTMLAGVAASRTLFGQMTQSLFRAPLKFFDANPIGRILNRYSSDMTVVDQTLPLVWFNFIPHFAIVAFGLGTAMVVIQLYGLAVVPFIYIYVLIGRYYVQPAREIERLSKTTKSSLLNLISESIDGVPIIRAFGPKQVTRFLRTNARNLDMNNEALFAAQVLTQWFTLHVQLTSAVIILVVMSSVVALRNFLSPGLVGLALTYLFSNMGYVEYIIVLWTQIETSMVSPERIAQYANIESEAPRVISGAVSQEWPAKGTIEFTNMGFRYKENEPLVLKDVNVHIQAGEKIGIVGRTGAGKSSLTMALFRINELAAGSIKIDGVDIAKVGVKTLRSAIAIIPQTPVLFKGTLRNYLDPFGAFTDEELWLCLRKVNLVDRISSAEGKLDSAVDENGENFSVGERQMLCMARALLRKARIVVMDEATAAIDHETDQNLQRVIRTEFASSTVLTIAHRLDTVCDSDRILVFDQGRLVQCDTPKALIAQGSGIFYDLCSEGGYLAKIIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XH24</accession>
    <name>A0A6G0XH24_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Carboxypeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_004790</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000063">
        <property type="protein sequence ID" value="KAF0739615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XH24"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014278"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF113">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CTSA-4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0739615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="502" mass="55001" checksum="F1E74D1B9B3F137E" modified="2020-08-12" version="1">MSSSPEWSKEKTPLVQTTTTAVKPPHRLARFPIAVAAVIALALGGGFVYLTRRHASRKLPTGGVTGGDSFCDTTNHEFGYIKLPHKVNDNYFYSFFESRNKPDTDPLLLWLEGGPGSSSTWAMLNVNGPCKIADDLSGTLPNPYSWTNNASVIWLDQPTGVGFSYGDAKDADSNEVDVGRNIYGFLQGWLKNHPKFQNHSFFITGQSYGGHYVPAAANYIVNQQKNPLPNGTIHINLVGIAIGNGLTDSVIQLPKIIDMVDSVREEYNITLVNPDQFKQMQVDANVLAGLVEKCQAPNESQACLDAEDVWSNKLLTPLITNPDRNPYDIRKLCSGPTCLDDGMTKTETFLNQDNIQKALGVHKKYTWNNATVANAYGADIGKSTAPLVPDILEAGVRVLLFVGDADLMCDWKGNDAWAKKLQWSGHDAYNNASVVPLQVDGKQAGEVRSSGRFSFVRVFDSGHGVPETQPIVALTLLNRFVRNASLAKDEQVAQEENDEIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XHC4</accession>
    <name>A0A6G0XHC4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_004800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000063">
        <property type="protein sequence ID" value="KAF0739626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XHC4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004194"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0739626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="242" mass="28164" checksum="156E5BCA24595904" modified="2020-08-12" version="1">MTTSKKRQHHDHSTWDRFRQVMVRFTANIEAVVAAFLVSANTTPKELLRSPQLPRRAAIPSGRAARRILRERRQACDFRSIADDCDSDEDTEGSEVVCPVGQDEMPGDWVEQWNVILSKGRFLDVCRQHVAACTIQRAMRQYYLSKQQHSIATHLFRVRLPLKCLFSLQQEINAKHNAATVLQMAWRRRRRPQPRMRPLKRKRSHDCDHNLKPSDVCRQSALLVRSLHRPETKELLLQALLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XHX2</accession>
    <name>A0A6G0XHX2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_004573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000058">
        <property type="protein sequence ID" value="KAF0739871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XHX2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020407"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0739871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="409" mass="45837" checksum="EC48F7D196CC85D2" modified="2020-08-12" version="1">MDPLLCSLINFAVHVEQMASASVSDFVNGNPDDGHRVVRKLLDDTFKSQSFNKLRDGNLGTHSLRKGAATYASRNGVPKDFVNRRGRWRSSKQIVDIYIDTTLAYPDACAAASLAGPAGPCIYVAMSEFACVTHDFLVDEVAPTVKRTMGPMLAKTLAMPLLWASFQPREPEKPSIIPEDLKSKIMHAYRRAGGSTEACPIRRIGIHVAGEGGQLNLIELQDIDVDNTRDRSDTMPRVDRNDMTAMHTQLLTIKRYMLDVMNELQRVHSTTRNEMQKMATVLNRIAIQPVVRSARSFTSSPAIDERQQVSRLSKRPKDLYTLWHEYQFGCNGFKPAKDFTAVERGANKFAYSRRKLFWDLISKLVRAGYTSDAAIVKVYHVFGRSQSVSNILLALRTHKQQGGHPALQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XIE0</accession>
    <name>A0A6G0XIE0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_004566</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000058">
        <property type="protein sequence ID" value="KAF0739864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XIE0"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0739864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="122" mass="13664" checksum="5484D59D4F981D78" modified="2020-08-12" version="1">MAQLGKRLAAGIGLLAASVGGTVATIELCIYYNEESYKEEFHRWETTLLPIKVDALQKLAATDSSAVDKIARLEQVVQHVDGVEAQWRRQQGDVLAMKRSWNETKDSLLLMFGRSDNRNQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XKL1</accession>
    <name>A0A6G0XKL1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_003744</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000042">
        <property type="protein sequence ID" value="KAF0740854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XKL1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000258"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0740854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="218" mass="24026" checksum="CC2426BE339CA9C1" modified="2020-08-12" version="1">MNAFVAAVFANDAFSFSSASTAETQWQVWMRPSESGDVIHLNVFVAAEDVTTLTSTAMTLDALIMQQHMNELGVTSDLSSFAQPFKSALITHGNVRVEVEDHSSVIVEITYAFGASLTRKGLFQMPMGTPVPRHVVDLLKDLHVTMNETHDQRAARRSHRTEKLLPIAAPLQLSEVPVLTSTQTNADVPLKRKVLPLGARRRVARGAKFARDDDDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XMR1</accession>
    <name>A0A6G0XMR1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_003211</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000036">
        <property type="protein sequence ID" value="KAF0741526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XMR1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000389"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF349">
        <property type="entry name" value="AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="15"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="314"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0741526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="463" mass="51068" checksum="A437A363793EB06D" modified="2020-08-12" version="1">MNLFVLPTRQDALVIVHLVCCVCGVGSLSMPYIFAQAGPTYSSIAFALNCFFNTYATVALSLCLLKLRDLPHIHTYLDLAVHVWGPKGAFFVQATQLTSCFMLPVAFLVLGGATLLPAIFEGAIDISSTLWILVMALVLLPINYIRVLHEAYLVLVSGAAATILADAIATIDAYVSHGRELYEPTDDVTFPHVLDTFGAFALAYGAAVVVPQLQHHHPRPEAMPRTLVWGMLMISVFYVALGALGYAHFGCASPSNLLMAMSATTSRRRIAYICMQIHISIAFAVFLNPFFVTLEKSILHKKAQDDEDDMDYNQLESPQQPPVQKTTTKASYSDNTKRILFRTIIIAIQCFLAMLAQSSFSDIADLIGASVMNVCSVILPLLLYVKLFDTEMGRAHKILCWFVIIVSIALGIYSTVQAVIRIVDNASSYKLFESVTTAKRTEYPYCAANYTERKAPWLDSFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XN24</accession>
    <name>A0A6G0XN24_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Band 7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_003024</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000034">
        <property type="protein sequence ID" value="KAF0741832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XN24"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000852"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08829">
        <property type="entry name" value="SPFH_paraslipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000008">
        <property type="entry name" value="Stomatin-like protein 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050710">
        <property type="entry name" value="Band7/mec-2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032435">
        <property type="entry name" value="STML2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327">
        <property type="entry name" value="STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327:SF10">
        <property type="entry name" value="STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16200">
        <property type="entry name" value="Band_7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="5">
        <location>
            <begin position="41"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="317"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0741832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="344" mass="37604" checksum="2E39AAD6D2125368" modified="2020-08-12" version="1">MMRAAPTLRRVLTPVRSFHASRQLLRIDDFDSMSRETPVNLGVLVVPQQRAWVVERFGRFHTTLEPGLHFLIPVVDRVAYVHSLKEEAIKIPGQSAITKDNVTIHIDGVLYVKIEDPYKASYGVEDPIYAVTQLAQTTMRSELGKITLDKTFEEREHLNKNIVASINQAAEAWGIKCLRYEIRDIAPPTSVKAAMDMQAEAERKKRAEILDSEGERQAYINVAEGKKQAIVLEAQGNAAAILARAEASAEAIKTLSAAIQSNGGQNAVALQIAEKYVEAFGNVAKESTTVLLPSNTNDPASMVASALSIFANVQKKTAGNSAPAPPNADNADYELDDTTNLPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XN33</accession>
    <name>A0A6G0XN33_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ae201684_003072</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. eIF4A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="VJMJ01000034">
        <property type="protein sequence ID" value="KAF0741881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XN33"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012589"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18046">
        <property type="entry name" value="DEADc_EIF4AII_EIF4AI_DDX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000089">
        <property type="entry name" value="Eukaryotic initiation factor 4A-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000031">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044728">
        <property type="entry name" value="EIF4A_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="16">
        <location>
            <begin position="34"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="65"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="246"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="34"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF0741881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="407" mass="46253" checksum="2C3980CA7159600F" modified="2020-08-12" version="1">MADSPRSPRGEENAQAPPQVLDGDIDTNWDEVIESFDGMDLREDLLRGIYAYGFEKPSAIQSRAVKPILLGHDCIAQAQSGTGKTATFAISILQKIDPSLRETQALILAPTRELALQIVKVVLALGDYTGTLVHACVGGTAVRDDIRTLTSGVHIVVGTPGRVHDMINRRAFRTDNVHLFVLDEADEMLSRGFKDQIYDVFRFLPEKVQVALFSATMPLDVLEVTQKFMRDPIRILVKRDELTLEGIRQFYIAIDREEWKFDTLCDLYETLTITQAIIYCNTRRKVDWLTERMQSKDFTVSAMHGDMEQRERDIIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRSGRFGRKGVAINFLTAADARYLRDIEQFYNTQIDEMPMDVADLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XP18</accession>
    <name>A0A6G0XP18_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_002831</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000030">
        <property type="protein sequence ID" value="KAF0742163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XP18"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0742163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="144" mass="15788" checksum="E4DB7048A7C79911" modified="2020-08-12" version="1">MERLAARDDGESFRDVVSVLQLKLVTENSLVLLRMSAVPSKNRYSLGSISFFASSTTDKAVMTLAGPVSIEASTMESTVDYTLPEKEHTNYISLEKAAPQPKSSPPASLKYVHLPMRYGHSYGATLPSWHAAKQDRLVKRAAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XPG6</accession>
    <name>A0A6G0XPG6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_002825</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000030">
        <property type="protein sequence ID" value="KAF0742156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XPG6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002299"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050560">
        <property type="entry name" value="MYB_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614:SF25">
        <property type="entry name" value="MYB PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614">
        <property type="entry name" value="MYB PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="13"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="3">
        <location>
            <begin position="18"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="3">
        <location>
            <begin position="72"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="72"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0742156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="291" mass="33311" checksum="0BAF8295F7CBCB34" modified="2020-08-12" version="1">MGEFYDEKYSLSREKGGKKAWSPDEDQLIITLVARLGCKHWSKLAKVLNDESTSGVMRTGKQCRERWHNHLDASIKKGPWTHEEEELLEAAHAEHGNQWSKIAKLFHGRTDNAIKNRWFAKQRREMRRNNKMSGRVDAVFDEDTEEQMTPRPEAHDRIRSDDRIIVVSPPAHRSLVDSGVGGISPKPEAWMHSSQYSHHSSGPWHSGSHTMESQIQWRSLQNQMDELGSLGLGVMPPDEDDAVDVNGSYTFGMRQMDAEGVMKRERSSVQEGRGGYPYMEIDLDWTEKVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XPZ3</accession>
    <name>A0A6G0XPZ3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dickkopf N-terminal cysteine-rich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_002611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000027">
        <property type="protein sequence ID" value="KAF0742518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XPZ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012317"/>
    <dbReference type="OrthoDB" id="73103at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026143184" description="Dickkopf N-terminal cysteine-rich domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0742518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="128" mass="13659" checksum="2AA38126CA53B46C" modified="2020-08-12" version="1">MTKILAVAAIVLAHVVTSFDPVQSHDEERLLAPTNCSVLDCKHGGCLYRGCKERIECSGGHCEFIDCVDPHCQGGVCAFIESASGTCNGGLCKYIKPTRSLKEDYCLGGLCTVDGKEHPSSFSTSLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XQ01</accession>
    <name>A0A6G0XQ01_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_002511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000026">
        <property type="protein sequence ID" value="KAF0742611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XQ01"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002906"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0742611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="310" mass="34326" checksum="F88FE971890EBD3C" modified="2020-08-12" version="1">MWVLQQDEAGWKDVSVSDSCAVLSQVPEPPTRLQMTCLTFRVPKSKYPTLVLAQLPASTCVVAANSSVLEFARDILRCFPSTIKPPVRTSFESDSDSDDDETDRLKKKPKTTKPEAIPSVGLSPETLNLSAEWSQRVRLIPGDSILNELDQFDLPPEVLSPLETNEESCYVIVNIPATEASFDGEANVGFLLTHPSRKAGFLTSLAPRLGFKSAETTMWKQTVVTFNGCRDLTAHGAGKTPAEMLDNIRRRHASGTFTKLVLPSLTWPQVVAKYVAQFPWLRGIQGETRMRKLMEVLPTEPVDIRLIGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XQA2</accession>
    <name>A0A6G0XQA2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_002502</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000026">
        <property type="protein sequence ID" value="KAF0742602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XQA2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002896"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF6">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="2">
        <location>
            <begin position="6"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0742602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="169" mass="18775" checksum="6714DDB4A9835E4D" modified="2020-08-12" version="1">MNEAESDELKQSVEQFAWWNFEHHPDTDSYSYVGIEETIEYLDSIVRTQGPFDGIFGFSQGGICAAHLLARQQQGDARFRFSFGIFSAAALMSDARYAIPLDSPLPFPSLHIMGEQDALISVEKSRALASQFANPVLLVHPGGHYIPTQKEPRDAWKAFLALQSAAVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XRU4</accession>
    <name>A0A6G0XRU4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_002128</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000022">
        <property type="protein sequence ID" value="KAF0743070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XRU4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015783"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008890">
        <property type="term" value="F:glycine C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06454">
        <property type="entry name" value="KBL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000006">
        <property type="entry name" value="5-aminolevulinate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00985">
        <property type="entry name" value="2am3keto_CoA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011282">
        <property type="entry name" value="2am3keto_CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01822">
        <property type="entry name" value="2am3keto_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005394">
        <property type="entry name" value="PRK06939.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF102">
        <property type="entry name" value="2-AMINO-3-KETOBUTYRATE COENZYME A LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="41"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0743070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="397" mass="43389" checksum="0517D8AD07AD158D" modified="2020-08-12" version="1">MSNLTERLAAELKDIQDAGTFKKERVITSAQGPTITVAKQDVLNFCANNYLGLSNHPEVVEAAKAALDSHGFGLSSVRFICGTQDIHKQLERVIADFHGTDDTILFPSCFDANAGLFEAILNSEDAVISDELNHASIIDGIRLCKAERHRYKHMDLADLEEKLKATQHCRTRLIATDGAFSMDGDVAPLRGICDLAQKYNAQVFIDECHATGFFGATGRGSDEYCGVRGRIDIINSTLGKALGGGTGGYTTGRQQVIDILRQRARPYLFSNSVAPAVVGASLKVFELLNRSSHYVDTIRRNTHRFRDAMTKAGFTLTGQRDHPIVAVMVGDARLASQLADDMLERGIYVIGFSYPVVPKGKARIRVQISAAHSIEDVDRCVEAFITCGKARKLLANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XS31</accession>
    <name>A0A6G0XS31_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_001960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000019">
        <property type="protein sequence ID" value="KAF0743271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XS31"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019775"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="350"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="399"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="442"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="540"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="706"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0743271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="730" mass="81761" checksum="F9F8B564FBA850A5" modified="2020-08-12" version="1">MLHNSVTEAAKAPPEVQHAGPAQPPSRLIYTRRNLLSTMAALVAFLTGLLVIYIYGSGVKSAMDSLKSTQFGINGSTFIYAQYESPLLMSFVKLLKTDAPSVVPAFQQTIQNASVVYIVQVDETSTLEFTTTNCVASGGTVTDIHDPQVVRDFVSLVYSGLGASFTNDLIAVIDCNFGAIVGQDSSTFRVHVVDPKLTYITTISTEAMQMTRPQMRQKTVSMPVIVVNTTFASIKMTPPYDDYSTAFSKPLAPTDVRVLVAIGYPFEDAIFQPLAVERVNEQSQIEGTLVWPNNWTESVYLNAYDGTYRDESTIFGYYFSFSIHIPDDAASNLGYLSFVGVPQIKNSWAWGYLLVCLQLCLVVALDMFSAVLVAVGTSRRVQFNVFHTLPDISHHLEKAILVHAILSIPCCLLDGGWAWYEWSVSSAQLRNIYNTNTIPRPLHIWCILLSWTVFVCTAMTKILRCNFNSTAILFVCLVADAHETYFNGPWGLFVEFSAQCMMDSNAESLTPSRSLHLDIWSYHSQPTLKPKFVLNEVSGFVYAAGFLLTTQVLMKVIYLIHGRLRRQVSPHSSDDKAISFPFEDGQTNTPLRGLFLSFDKHEEDKASSTILATPAWIWYLGDVVVDDVFVFRLTDVPKLWLNQLLRRDYFHIYGYDVTLNEVNTNLKLFLHEDFQNAASLWRLSLVPVHQKHLQDNKVLSLVNATRKGSNASKRTSNDSKKSKVHVQPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XSA3</accession>
    <name>A0A6G0XSA3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LNR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_001918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000017">
        <property type="protein sequence ID" value="KAF0743447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XSA3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021176"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0743447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="38668" checksum="63A8528EEC0632F6" modified="2020-08-12" version="1">MLLPTSALDLVAKSITYIATADFLRRAIRELSDTSQYMSSLKVPRRRRLLQLNAIFCVAWSVIFSILICRAVGFRHPCPPFCATQAYSMLDLSCQCIYADINCAKLGIHDPSPELAPRDVGTSLFYLQVSRCPLRDGFSTEILEPFHQLCEIFVLFSEMEAWEGPLPSTVTSVLIRFSRLRAIPKALHQNIPKTLVLLQLEGCPLDPIPKMVFSWMIFANLSFTSVLSGFLNMTNLQIIDLRLNNISRIPWPLVERGVALDLSLNAINVSSAEIVDPRAIASRQLILDGTPFCHHKGEKSTSCNSICGEHCNVNWIGDHWCDWPCFTAACNFDDGDCDTFGFDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XSD4</accession>
    <name>A0A6G0XSD4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_001944</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000019">
        <property type="protein sequence ID" value="KAF0743254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XSD4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012844"/>
    <dbReference type="OrthoDB" id="10273165at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="5">
        <location>
            <begin position="2"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="5">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0743254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="139" mass="15762" checksum="88C6F5E0A4630F10" modified="2020-08-12" version="1">MASSSLICRYFHSRRGCIRGRRCQYDHCGVPSEVPCGFFGTSLGCKFGEKCKFWHEIQDDILALDELDDFVEDTDSDVSIKEEPIVVMPGKARVVWRIDTTRPSKRMKLEPSHIVVHDIKAFDTAITAADEVKYSALMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XSR3</accession>
    <name>A0A6G0XSR3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_001711</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000013">
        <property type="protein sequence ID" value="KAF0743563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XSR3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012666"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006181">
        <property type="entry name" value="D-amino_acid_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF11">
        <property type="entry name" value="D-ASPARTATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00677">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="2"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="38"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="304"/>
            <end position="309"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000189-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0743563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="329" mass="36258" checksum="5FE9013D7A2EC98D" modified="2020-08-12" version="1">MKIIVVGGGIVGLSTALALLEHGFLDVKIVADSFDDTTSHVAGAVWRPVFAGSTSDYTMDRWGHETMLWLRGLIEHYGTDVVGCKRTPGMELQDTPIESHPYWAHSVEDFRLLTPEEALKHAPYTKKYGCVFTSIMIHPGVLMDWITKQIQARGGTFERRHVSSLNDLDADIIVNCTGVNAGKLVNDANVYPVRGQVIKVINPAITRFITVESHGQYTYILPRHNGEVTLGGTAQPHNWSTENDQDDVKQIMERCIALMPEVKDSKVLFAKAGLRPTTTTGTRVELDAKRTATGAWIVHNYGHGGSGHTIHRGCASDVVQIIRSLHAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XSW3</accession>
    <name>A0A6G0XSW3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helicase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_001800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000015">
        <property type="protein sequence ID" value="KAF0743506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XSW3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019895"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005114">
        <property type="entry name" value="Helicase_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37066">
        <property type="entry name" value="HELICASE-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37066:SF1">
        <property type="entry name" value="LNS2_PITP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03457">
        <property type="entry name" value="HA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase-associated" evidence="1">
        <location>
            <begin position="10"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="1">
        <location>
            <begin position="320"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0743506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="396" mass="46275" checksum="E69E31048E56DF65" modified="2020-08-12" version="1">MKDWVRILLQWEENLEALRIFKSIHGNLHVPKYYKVKTEDAQWPEKLWGKNLGFAVVRLRQLQERMDPSKRETLDSMGFIWDAIQAKWEKNLLSLETYKAIEGDLLVKTSGTTSFVVPERDPAWPKDTWNMRLGYLVSTCRKKKESLPRNIHDALTAMGFVWKVKDKGTGPGRPPRISTAKQHEILEIVQVQHKLQGHTRFTTLPNPFKVPASSEWPQHLHGCIVETSKFRRAYRMGLLDASVVAKLDDLGFVWNDNQLQWSLTMEALQIFKNIYGHVDVPQDFEISQEDHLWPDDLWTMRLGIKQELAALDFVWDANKLHWNRKLLALKTYKQLYGNLRVPHNFIVPKDDPAWPTDVQDIELGTVVNNFRRNQATLSDEKKRELNKLDFEWSAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XUZ5</accession>
    <name>A0A6G0XUZ5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_000969</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XUZ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010436"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052050">
        <property type="entry name" value="SecEffector_AnkRepeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586:SF3">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0744493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="345" mass="38313" checksum="7CC64696CAB75839" modified="2020-08-12" version="1">MSSLTYLKVAASFDLLLLVFDYQDGVLHIHHPLRRVGSLAWDICPSSHARLCSSMLEIDAILSPWYKRHGTSRIRTFVRSTNAFRHNVVACHAAYDGNIAVLRALLEATTHKCAEANLIDWAACNGQLHVIEFLQEATDGRARCTPWAMDSAAKHGHVEVLKWLHHHRSEGCTTAAVREAARNGHLHVLQWLARHCICLWSDAMDLAAANGRLAVVEWLHESKRPCSTKAFIGAASNGHLKVVQWLDQHRSAYCTTDAMDGAAKNGHLDVVVWLHHNRREGCTTAAMDGAALRGHIQVLRWLATHRTEGFSKASTKTAKLNGQDNVVQVLRAHRKLAKPASCIVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XVH1</accession>
    <name>A0A6G0XVH1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_000936</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XVH1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001485"/>
    <dbReference type="OrthoDB" id="10261046at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030123">
        <property type="term" value="C:AP-3 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14834">
        <property type="entry name" value="AP3_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000001">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027155">
        <property type="entry name" value="APS3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000804">
        <property type="entry name" value="Clathrin_sm-chain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00989">
        <property type="entry name" value="CLAT_ADAPTOR_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="10">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0744458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="162" mass="18498" checksum="53D0D899759C4F49" modified="2020-08-12" version="1">MIKGVLIVNNHGKARIVKFYEHVPDAEQQAVIRDIYTQVSKRPDTLCNFLEGSVRYWGDGIKLIYRHYATLYFVFAVDKQESDLGILDLIQVFVETLDKCFENVCELDLIFHSDKVHYVLDEIVMGGMVLETNINEILTAVNEMNKLDANSTKRSLPGTGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XX00</accession>
    <name>A0A6G0XX00_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_000597</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000003">
        <property type="protein sequence ID" value="KAF0745017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XX00"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004131"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF6">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0745017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="223" mass="25127" checksum="C2B2EC7B9ABD933D" modified="2020-08-12" version="1">MVRKLRILCLHGWRTSTTVISLQVAGFRQAFGQSGAEFVSLNAPFPATGPAQEAIRKFFGESGPYYQWWDAVKVPDFVPEKTTYVGLERTLEFVQRQIHELGPFDVVLGFSQGAALTTLLTAHYHAHAKEIPYKAAVLVCGLIPRDGLPNDLVLPFDIPSIHILGQQDEMLSLGHDLVETYSATSRKLYIHDEGHRFPALPKYKPMYVEMVEFLRHVCTDNQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XXN2</accession>
    <name>A0A6G0XXN2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycosyltransferase family 28 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_000350</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004274"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016906">
        <property type="term" value="F:sterol 3-beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000163">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000009">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="EryCIII-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF13">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="EryCIII-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase family 28 N-terminal" evidence="3">
        <location>
            <begin position="62"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Erythromycin biosynthesis protein CIII-like C-terminal" evidence="4">
        <location>
            <begin position="373"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase family 28 N-terminal" evidence="3">
        <location>
            <begin position="776"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="698"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0745322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1327" mass="147079" checksum="5981C508231B1F06" modified="2020-08-12" version="1">MAADDTIHEAEPAAIAVQNESGRIELQFNNPDAIDIPMFVQSSSANLTTDSLPSQKIPSMNICIMIVGTRGDVQPFVGIAKRLKADGHRVRLATHAVNRSYVQHENGIEFYPLGGDPKELASYMVKTGGHMIPLKYELLTKDTPRNVHMLEEITYSTWPAVTAADPEGSDAGLPVFQAHAIISNPVTYGHIHVAEKLGIPLHIMFPQPWVPTQEFPHPLSNLPYKGKREKRNYLSYSMVDALMWQGTEGMINRFRTEVLGLRKIRKGNHGRSLVLDWKIPHSFMWSEHLVPSPPDWDPALYDVIGTVTADSPTKITPYTPSPEFEAFLADGPPPIFVGFGSMVIPYAVKTTQLIINAAAAAHVRVVIQSSWSDMTHGGVVKIPSNIFILGNCPHDWLFPKMAAVVHHGGAGTTAAGLFAGKPTFIVPFFGDQPFWGWAIERAGVGVHPCPVNDLTVDKLKGAFEQMMSPAMIAKAQEMQAKMLKEDGVENAVESFYRHLPWEVMLCALTPEHLATKFLERDSLQVCAACAYVLQSRSDQAIAEHRYKEYGIVGPMSGIEGASQGMGALMHEIGGAVTGVVGEPARGFKEKGIRGGAVGVAKGVGGLVLRPLAGVAIFADHVATGHYNLWHRNDKAKQKQCRFDGRHLFKREDQSAIDKSLAPIVAVKLTKEEKETISKALDKLKHGESLTKHELDTVMTVRHEDDTDETSGSSGNDEDDIEINASVTDLKVRPDGTLDLENDVDKPEALPTKLTDTVAPILGDSWEDFKIPVKLSIAMLAVGTPHAIEMFIAVGKSLAEDGHRVRIAAPRQVQDTVRSFGLEYFELDGNPSSSQELLRALAYTPTDDKAYEGPWNDIPAFFASCWRAVKSCGFRADAIIAHPGVLVHVHVAERLGVPLHLLSSHPASPTKDFPHPLIETMRHPDKWSAWLSYAAIDSFIWRFTQDDMNRFRVQQLGLQGWYPQHPPSWSTWQIPITYCWSNLLLSKRPEWGSEVDVVGFVALPSHDKTTYVPPVAVAAFFDTNRATIYLAMDAMDNETLIPILHEVLNHHEFQIVLHRIDDTFENLFPIDRLAILDGSVPIEYVFSKCHGVVHQGRYHNVLAFLHDPKPAVVVPHTGIQKLWARRLHDLEEHHHVSPPVHFTEVEANAKALGDILAAVHATPSISAAFTDAVSLESKQAVRRAVTSFYKHLPLEAMVCDILPTKIARLYDPETQLKLSYEVDFVLRQDGHAVHEYVTYNPMHYSLQHGPQVATASSTENNKRVDKKSHKAAVGGLFKKKKSVPVIRKCESLPSVPEDLTAYWTTPQEEDELRRRVNAAYDALLDQQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XXR9</accession>
    <name>A0A6G0XXR9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cysteine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cysteinyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_000326</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="2"/>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XXR9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018146"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000027">
        <property type="entry name" value="Cysteine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1910">
        <property type="entry name" value="Cysteine-tRNA ligase, C-terminal anti-codon recognition domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890:SF3">
        <property type="entry name" value="CYSTEINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="CYSTEINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA synthetases class I catalytic" evidence="12">
        <location>
            <begin position="46"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="593"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="601"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0745298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="634" mass="71315" checksum="A7A7A2A83F5F4EF2" modified="2020-08-12" version="1">MMWWTKLRSAIKPRQVCWFSSTKHQNAAPLVALNSLTGQLDPFPSSPTAIKWYVCGPTVYDSAHLGHARSYVSQDILRRILTKHFGQEVFLVMGMTDVDDKIIASAAQKNQPFEQVARHYEAAFLRDLASLNVLRVSAITRVSEHISDIIAYVQGLEANNFAYTTSDGVYFDTVAMGSAYGKLAPSAATADDYADADVEEGSVGSEKRNVRDFALWKFSKTPEEPGWTSPWGRGRPGWHIECSAMTHHVLGDSIDVHSGGIDLRFPHHNNEIAQCDGFHHHKPGHNWCGHFVHFGHLYIKGLKMSKSLKNFITIDALLKEYTADAFRLFCLQYKYNVNVHFSDDRMRDANAVLQRFHSFLQTIQSHLRANEATFEVSKRMEEEDYELLAALAQCKASVDAALRQDFDTPTALQALLDLISTTNKAWKERPQIPDEVLSSIATYVMQVLDLFGIESLQYRSIQLAIASSSDAQTSAINSTEILDIFTQFRAQVRQLALTNTSDKVAQGILQLCDQVRNEVLPRVGVRLEDLAPGKSFWRHQPWQEAPTENADDGKAAEKELLAAKAAEFEAEMQIAPVDFFKLSAQFQGKFLSFDESGTPTHDGKGEELTKSARKKLAKKLEKHSKSYEKYWSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W4H8</accession>
    <name>A0A6G0W4H8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_018859</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000361">
        <property type="protein sequence ID" value="KAF0721872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W4H8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015422"/>
    <dbReference type="OrthoDB" id="79626at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026147320" evidence="2">
        <location>
            <begin position="17"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0721872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="212" mass="20951" checksum="783D998CA929199C" modified="2020-08-12" version="1">MVSALLVAALAATAVAQCQDSLKVSLQYTSDIYCVAQDPCSGVYFPGKFACPSKGAVAINTGVTLQADSCCSIINDLNAVGCVIPTTSTKCISKDAGPLVPETTPSNQTTTAPTTAAPTSATNATTTSPGTTTAPGTTAAPTTTPSNTTTSLSNTTSAPNSTDVTLEPSNDITGPPSTAKPSTAAPTTTAKPSSAVQAVASTAFLLLALAMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W500</accession>
    <name>A0A6G0W500_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_018661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000346">
        <property type="protein sequence ID" value="KAF0722122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W500"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013013"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0722122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="231" mass="26418" checksum="7324EC913E99EF3F" modified="2020-08-12" version="1">MEAFMKLVPNGIAYIYLVDTNQCEDDKRVFKFGRTTNVKDRFYSHASSFGDDCRLDTLVLVPLNILSAAKTQFKRMIADMFRCPSGNTQELLVLDTDGHNVIRKCMQTVADTYNGNLALHSHILDSKVKQVQNQMHELCLKHERQIVVLECMLGVANELARGKIGVLEQQLETAQLQLEQQAEMSRLRLETQELKFNTQLLEKDRRIAELIGLEEEDGAIRRVKPACYRAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W676</accession>
    <name>A0A6G0W676_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_018293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000329">
        <property type="protein sequence ID" value="KAF0722627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W676"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010852"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0722627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="159" mass="17795" checksum="4783C69B5D56E369" modified="2020-08-12" version="1">MATNSTALSWRSGIPLTDLTVFELYDVMELRAKVFIVEQTCIYQDLDGLDKACLHVLGTDSTTAIRAYARVLPPKTKGKYQINPMIGRVVIAPEARGSGQARVLMEKAIDVCRIHWPDLGIDIGAQAHLEKFYSSLGFRKTSEPYDEDGIMHIDMHRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W6U3</accession>
    <name>A0A6G0W6U3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_018153</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000323">
        <property type="protein sequence ID" value="KAF0722801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W6U3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006634"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0722801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="196" mass="21921" checksum="5AFEC0A2271636D8" modified="2020-08-12" version="1">MLNKLPKLLCDAVLSNFDVNGAVPLTREYLDTCLENLRESMSTKGQACIVPEQPAISTGATVATFTWVGRLHPVQADFEIPKCKVYSLWCMWFEGIPASNIGTLRKLRSLDLQKRGDAAKLSKARKVIAIVASAAGYPNLLDVASMDAVPRKLAYERGFLHKTKSMMQLMSPDEWAAHRVNEMSYITFYDIVLKHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W730</accession>
    <name>A0A6G0W730_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Propionyl-CoA carboxylase beta chain, mitochondrial</fullName>
            <ecNumber evidence="4">6.4.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Propanoyl-CoA:carbon dioxide ligase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_018828</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>butanoyl-CoA + hydrogencarbonate + ATP = (2S)-ethylmalonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:59520"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:60909"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:59521"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>propanoyl-CoA + hydrogencarbonate + ATP = (S)-methylmalonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23720"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57327"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:23721"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate metabolism; propanoyl-CoA degradation; succinyl-CoA from propanoyl-CoA: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein, biotin carboxylase and 2 subunits each of ACCase subunit alpha and ACCase plastid-coded subunit beta (accD).</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The holoenzyme is a dodecamer composed of 6 PCCA/alpha subunits and 6 PCCB/beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AccD/PCCB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.3" evidence="4"/>
    <dbReference type="EMBL" id="VJMJ01000359">
        <property type="protein sequence ID" value="KAF0721892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W730"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019306"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004658">
        <property type="term" value="F:propionyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000017">
        <property type="entry name" value="Propionyl-CoA carboxylase subunit beta 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000016">
        <property type="entry name" value="Propionyl-CoA carboxylase, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051047">
        <property type="entry name" value="AccD/PCCB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000438">
        <property type="entry name" value="Acetyl_CoA_COase_Trfase_b_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43842">
        <property type="entry name" value="PROPIONYL-COA CARBOXYLASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43842:SF2">
        <property type="entry name" value="PROPIONYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01070">
        <property type="entry name" value="ACCCTRFRASEB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="10">
        <location>
            <begin position="43"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="11">
        <location>
            <begin position="303"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0721892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="547" mass="59969" checksum="6F9691C8064BAE5F" modified="2020-08-12" version="1">MRTGLWRSVAATALRPSPMSAAMRVTAGAAFSTAEPITPAARKLAFKQKLEDTRAKALLGGGAKRQEAQHAKGKLTARERVELLLDEGTFREYDMLKTHRCKDFGMEKQEFPGDGVITGHGLINGRLTYVFSQDFTVLGGSLSETYAEKIVKVMDKSLKMGAPVIGLNDSGGARIQEGVASLAGYADIFQLNVLASGVVPQLTMVMGPCAGGAVYSPAMTDFVFMCRDSSYMFVTGPDVVKTVTNEEVTQEQLGGAVTHTKTSGVAHKAFDNDVEAIRELRRFFDFLPLNNKEKPPTKEFEDDRFRPIPALESIVPPDPNVPYNMKDVIHTLVDDGDFFEIMNDYAKNILIGLARFEGRVVGIVANQPMELAGCLDINSSVKAARFVRFCDSFNIPIVTLVDVPGFLPGTDQEYHGIIRHGAKLLYAYAEATVPKITVITRKAYGGAYDVMSSKHLRGDVNYAWPSAEIAVMGAKGAVEIIFRGQNVEENTADYEEKFANPLVAAQRGFVDDIIEPTSTRLRICEDLEALQTKKLENPWKKHGNIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W7Q1</accession>
    <name>A0A6G0W7Q1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_017792</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000313">
        <property type="protein sequence ID" value="KAF0723171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W7Q1"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0723171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="102" mass="11203" checksum="B5D78163FC012DE6" modified="2020-08-12" version="1">MLPVLLWLASNADQLSSSCRRGHQVSPPDRPTCGELPGPPATTQLETTTNSSNFQDSSQPSKNTSLQPRPKSCLYERPDDDRPTLRCRLLKPTKAQGSSQQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W8J4</accession>
    <name>A0A6G0W8J4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_017886</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000314">
        <property type="protein sequence ID" value="KAF0723139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W8J4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012865"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053083">
        <property type="entry name" value="TF_kinase-domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44305">
        <property type="entry name" value="SI:DKEY-192D15.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="576"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="854"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="877"/>
            <end position="887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0723139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="887" mass="99120" checksum="2B9D48BEB1241BD8" modified="2020-08-12" version="1">MADGGTLLECSQSTGEDDITWTFGGVNEDGSFYFINTKTGECVQNLPQTTATSAGSPEDPSALFADHAAIYDSYEPAVVDCVLDLVTSIEDRLKDWTRRRQRNAKSIAKRARKQAKTSTRALKPSKSPRTISNQTTVRDENEQTTATNDDSRLEQRILHRQLTQKKQSEARQRANFKHEESHVRLHLTRVLLAQATNGLDVHGKIDFVAPPEHEIQVRFQERQQLAALFSQLLDNSASSLSSLEAFYALSTKSELQKTVEARRGLLKLTTDGILQAFFLQLPQPLNVVRFVRFVEICEDVMDQVDRIKLAIESAKLGIVSADLVEWHQSMASVKTGLSSFRQLAAVNRLQQSLTTALDICRSQLRPILHFHMATNTSKSQDNASHATILQQPIWQLNHKHVYIQIDGSQPLYCVHCRQARIRLEKLERLELEAHHRAHWGRSLAHALHEKEAAILQWHRGTQNVPAMPTMSVNATVGGILNDLVAAVAFLESFATWQSLLFAENPLKASETAETLHLLTKSRDDLERQEFERACLFDVDELSADFAEAATIAMEKPLIREQEAAHTELARLVRACIEPSMYIRRLQFQQLLAVRSPTDNMVLRVLESGETHETCILTTMRCATREQAAAIVEFAKRLENGALPHVVGVKHAFSYMYQHFSTGGNLNECWPIVFVVTKDCERAFQTPLKSLTPTEVLDIICTVSAALSALHSQGFVHLNVNPGNLYRAKDTGELQLGGFLAFKHPYTPAELNQSQTIALLLPPTVLPPEFAQGSSTAAAINDKTDMWALGCLLYSLLTGTTHQILKDKPLSAIMKDIPLRYGPNLRSCLRMLLQPLPRHRPTATEIFNFLSCVSPDEKDPPLAEPPQPKTTKKKSLPSLPTRSSSVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W9G7</accession>
    <name>A0A6G0W9G7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_017434</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000296">
        <property type="protein sequence ID" value="KAF0723762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W9G7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021784"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF288">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="12"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0723762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="275" mass="31167" checksum="ADE87F223C9D833C" modified="2020-08-12" version="1">MISSDDVDFCPEDLQTLLGEGGFGKVFSGKYQGQPVAVKQFMDSSIDSADFEKAITKEIKAWQSISHEPHILTLVGVCTKISHPILVSELCRTNIRRYVRDHPDILILMIYQFAKGLATLHKANIIHRDLKGDNVLVSFQGIVVVADFGLSRTVTSLHHTKSTVASTLNWMSPEQFLNARNVTSKSDVWSFGMTLWEILCNEIPFYRCSENEFRTEIFTTATDRPEKPQNLDSTLEPLWSLITKCWLLDPEARPSAEEIVKHLESEYGFQVKKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W9M7</accession>
    <name>A0A6G0W9M7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_017269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000292">
        <property type="protein sequence ID" value="KAF0723888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W9M7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020782"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0723888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="109" mass="11592" checksum="A536F2693CBAC3CA" modified="2020-08-12" version="1">MPSTKEFLDGPSTITNRGFFLLGPSNVIFYSYRVHRASGTLALLTSGAAVIYGLYSGCGRANSGPQGQLIAIVLVGLLHITTVTYLHSSKNQTTKAGFSTVGFHRGLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WD39</accession>
    <name>A0A6G0WD39_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">CBM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_016288</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in degradation of plant cell walls. Hydrolyzes the feruloyl-arabinose ester bond in arabinoxylans, and the feruloyl-galactose ester bond in pectin. Active against paranitrophenyl-acetate, methyl ferulate and wheat arabinoxylan.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the faeC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000248">
        <property type="protein sequence ID" value="KAF0725203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WD39"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019990"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043595">
        <property type="entry name" value="FaeB/C/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38050:SF1">
        <property type="entry name" value="FERULOYL ESTERASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026266976" description="CBM1 domain-containing protein" evidence="11">
        <location>
            <begin position="33"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="12">
        <location>
            <begin position="33"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="79"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0725203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="358" mass="37817" checksum="678FEB54B32D71C5" modified="2020-08-12" version="1">MTFFIRLGPAKAAMKFAFACVALVTVTELAQAQSAGPWARCGGQGFTGSTECPQGFTCSAQNSWYSLCLPSNSGLTPSFAPTADPSTPPSSSSSSPSPLSSGGNKSAGCGKAAGIASGTYSITVNGKVRQYILRVPQNYNQDTAYKFIFALHWLGGSMTQAQAIEGGFYGLQALAKETAIFVAPDGLNRAWANVLGEDVLLMDAIMEKIESNLCVDTTQRFSTGFSYGASMSYALACARPDKFRAVALYAGAQVSGCAGGGTKPVAFWSTHGLADNVLPYAMGRALRDHFLQVNGCEAKNAPEPVFGQPHTKTVYTCKAGYPVQFYAHTGGHVADPKDPGQFQSWAPAEVWAFFSQFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WDE8</accession>
    <name>A0A6G0WDE8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cellulase</fullName>
            <ecNumber evidence="3">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ae201684_016109</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 7 (cellulase C) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000243">
        <property type="protein sequence ID" value="KAF0725336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WDE8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014189"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014420"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.100.10">
        <property type="entry name" value="Glycoside hydrolase, family 7, domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001722">
        <property type="entry name" value="Glyco_hydro_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037019">
        <property type="entry name" value="Glyco_hydro_7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753">
        <property type="entry name" value="1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753:SF1">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE CELB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00840">
        <property type="entry name" value="Glyco_hydro_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00734">
        <property type="entry name" value="GLHYDRLASE7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026037249" description="cellulase" evidence="13">
        <location>
            <begin position="20"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="14">
        <location>
            <begin position="442"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="392"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF0725336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="480" mass="49559" checksum="33865778C90BD207" modified="2020-08-12" version="1">MWIVGLQMAVLPLTECVHGKCLPPPMKIAATLAFLSSALVAAQQVGTFNPEVHPVLTTLKCSATGGCTPEVSKVVADANYRWVHNVGGSTSCQNNGQWNSAICPDAATCAKNCAIEGYNYTSAGVVTTGGKLDVQLNNRFSSTKNSPLTSMSPTFLGGNAALYFVPMAQDGGKVGNNNAGAAYGTGYCDAQCPGGINFINGQANLANKGQCCAEMDIWEANKFANAFTPHPCTIDNIFTCSQECNSCDKGGCGVNPYGANHQFYGPGSSYTVDTTKPFSVVTQFITDDNTANGNLVQINRFYVQNGKNIASEQQITNSFCNQNSVSVANGGLKAMGRALKTGMALAISVWTGDMAWLDSGANGPCPSSPPTVTSASYSMTNIRVGDIGSTTNAVVPPTPSTSPSTKAPTAAPVTTQATSVPVTSRATSAPTSAPTTAKPSAGAVGAWGQCGGNNYAGPTACISGYKCNAYSGWYSQCIPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WEQ8</accession>
    <name>A0A6G0WEQ8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">phosphatidylinositol N-acetylglucosaminyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.198</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">GlcNAc-PI synthesis protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_015682</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.198" evidence="2"/>
    <dbReference type="EMBL" id="VJMJ01000229">
        <property type="protein sequence ID" value="KAF0726018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WEQ8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001677"/>
    <dbReference type="OrthoDB" id="734129at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017176">
        <property type="term" value="F:phosphatidylinositol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03796">
        <property type="entry name" value="GT4_PIG-A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000188">
        <property type="entry name" value="Phosphatidylinositol N-acetylglucosaminyltransferase gpi3 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000093">
        <property type="entry name" value="UDP-GlcNAc:PI a1-6 GlcNAc-transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039507">
        <property type="entry name" value="PIG-A/GPI3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013234">
        <property type="entry name" value="PIGA_GPI_anchor_biosynthesis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08288">
        <property type="entry name" value="PIGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="PIGA GPI anchor biosynthesis" evidence="9">
        <location>
            <begin position="58"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="8">
        <location>
            <begin position="209"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0726018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="455" mass="51155" checksum="21CCAE5C4C9EB443" modified="2020-08-12" version="1">MGNASGDDDSDRLRIAMCCDFFYPRLGGVEMHIWSLSQCLLRRGHKVIVITHQTDGPNKRQGIRYMTNNLKVYYLPLVPMVDNVTLPTFTVGFGLFRTVLIRERIQIVHGHQATSAFMHECILQAKTMGYKAIYTDHSLFGFADAASIHLNKVMKFTLSDIDHAICVSHTCKENLVLRASLDPSIVSTIPNAVDASKFTPKETDAPPIDPLKDPITVVIISRLVYRKGIDLVGKTIELVCARCPNVKFLIGGDGNKRLLLEEMREKCQLHDRVTLWGAVPHEEVRNVLNQGHIFLNSSLTESFCIAILEAAACGLFVVSTRVGGVPEVLPPDMIRFSKDITPEDLADAVVESIPLLAKVDKQAFHNRVEKMYNWYDVAERTERVYRNVIQLPTSPLIHRFRKYYGMGPVAGILGCIIAACLFLYLQYLAWRKPADEIELAWDCPLHAKPPPKETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WF35</accession>
    <name>A0A6G0WF35_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tyrosinase copper-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_015650</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000229">
        <property type="protein sequence ID" value="KAF0725985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WF35"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013885"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF126">
        <property type="entry name" value="TYROSINASE-LIKE PROTEIN TYR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026122399" description="Tyrosinase copper-binding domain-containing protein" evidence="3">
        <location>
            <begin position="16"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="4">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0725985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="513" mass="57315" checksum="FA6845197F29114B" modified="2020-08-12" version="1">MRLLVLLWLVSLALAQNSKCDPVRVRKPWSLLTAAEKKTYVEAVGKAMASGYHHQFVEIHTEPSSEAEAHGCMFIYWHRKFLLAYENMLRSLDPAYECLTIPYWDYATLSSSYVSGSCSSIYSCDSGIINAFGGNINGNVRRSWDSVNGDKISASACVANNPLNNFCQSSSAYQNKRCMGCVPRNDFSRARVPAEANIASVFNQVLGGSNSRTGKTLDEATRGIQQGCHNTIHANIGATMGTFESPADPLFYLHHAQVDLLHRIYFKCNVADAKRGVKPVLSKTQKTKSSDAKIWTNCARYDGSGINPTDPVRMIVGEKGGKKWNVNDPNSPLNKFFKDLPLSYSDYIDGDDLGSFSYQYQYTGMLADMLTKCKSFVVPRRASLMEGEAEESYPINPNYIDRCVERPRLACEILQTSFIDYLSGAAGYYGWSQDTLAEQLDALLCVHHEECLGGCSDYSAEFKANFHPKGPPRCKVIMDKLKNRELFIELPNWRKVMANFFPCGDEQALLDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WF46</accession>
    <name>A0A6G0WF46_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_015684</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000229">
        <property type="protein sequence ID" value="KAF0726021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WF46"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001675"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000013">
        <property type="entry name" value="Histone-lysine N-methyltransferase SMYD1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF251">
        <property type="entry name" value="EG:BACR7C10.4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="8">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="9">
        <location>
            <begin position="43"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0726021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="434" mass="48143" checksum="5639E76EEE5606CC" modified="2020-08-12" version="1">MYQRQALPDRGDGAVATRAIRAGTCILRSDPVVAVPLDMAITCAYCFAPGARRCGLCKVFHYCSRQCQLADWAVHSAECKYLAKHLHENPITPTLLMAVRFLRNPSAMNAVSHLVSNVQSHLPSQREDYRTMSMLVMSVLTAMKSSNLPSIEAIMALFAQFNCNAFTLCTLQQVPVGIGMFPDAALLNHSCAPNCILTFHKRQLQIRTIRDVSPGEELTISYIELMSSHTTRQEELLASYFFTCKCSRCLAPEPPDLTATLTSDDVDSMELQIDHFLAQADKFEHAHDTRRAVDCRHRALLLAQSIYHPRNAKLTLPSETLANLITSSEHASSQTVQDVAVAIECYATVMANQRWLYDSMGLQAFTGLVALKSAQLLLRQAKPATFENALTLARDACRFLSITHGEDCHVMDNALAVLHVIQHVQHENGSTKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WF83</accession>
    <name>A0A6G0WF83_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_015493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000222">
        <property type="protein sequence ID" value="KAF0726217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WF83"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014246"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0726217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="28161" checksum="8ACADFB43A2A4E39" modified="2020-08-12" version="1">MVPTFASYGSETDEATDSRLAKRPLLIKAKRSRVFLAILSATLVISSGAAIYGSFDQTAQCQYTTEPLRAAATRRLASPALFQMIDVDASGAVNLTELVHYFTLDKNREVIQLHADEKKAVDDASRDFTKRATCLIAGYTSVVHNDVIRSMEQLGEVLAYCHEDLGLLPSPNGGPFGLPSNNNAETVFYSRQEVIAYVKTKTTSGFFLQCTLDALDQYPQGKKFTKQDLDSISSVVLTCLKSWLSRHCAQAAPVTYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WFB0</accession>
    <name>A0A6G0WFB0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_015590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000226">
        <property type="protein sequence ID" value="KAF0726077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WFB0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018010"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0726077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="193" mass="21548" checksum="760BFF5BDB899916" modified="2020-08-12" version="1">MSDGSSCEIPRNNCFLRHEGVHVDDPSHALCYGASIKAGKHSRCRNYLRRRKVHNPNYHRNYYKAVGKVPDESSARGLVLNGSTLLREIERTFGNRSHTVRSKSGGGRSKSRSRADDEKEDELYLRGPQYPTHLTYDRRRDRWANITRFLAAVDQGPDADDQGPDGPPDNHPNDDAQPPDSPPAGGAANMVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WFU5</accession>
    <name>A0A6G0WFU5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box/LRR-repeat protein 15-like leucin rich repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_016113</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000243">
        <property type="protein sequence ID" value="KAF0725340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WFU5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002258"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050648">
        <property type="entry name" value="F-box_LRR-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13382">
        <property type="entry name" value="MITOCHONDRIAL ATP SYNTHASE COUPLING FACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box/LRR-repeat protein 15-like leucin rich repeat" evidence="2">
        <location>
            <begin position="146"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0725340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="400" mass="44190" checksum="CB707FBA5D8952AD" modified="2020-08-12" version="1">MTSTNQTCRRECLGGGDHATQSNAKSTKPRLTPPTACFELLCATLVEHVAEYLTVPDKLKLAACSRSLAKENLITTMTTNCGDCNNCMSDLQHLCDSSSERKWSAEAWTAVFKRFGHSIQDLSLVGCDGIALESFGSPEAALMLENIKSLRIAKCKSLDEVSLATIVAQCKNLQEVHICDMPLSDAALSVLIQNNCTSLRVLNVTGCHKLVGSALQYLVQTQVEEVILEGCHSIKVLEIEGMLKCCQSLKSFNVSYCHNLNDCVALAISKYASQLEHLNLRYCYKLTDVGVGFICSTLTSLQSLDLSQCPRITDAAVCTIAKSLLRLKELKLSNCRHLTPSAIVANLTFVEIRNEDRVARVDVPKETCRKAVCGWEQSDQVGVFKRQAHMYRYPVIRQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WFY1</accession>
    <name>A0A6G0WFY1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CBM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_016074</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000242">
        <property type="protein sequence ID" value="KAF0725432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WFY1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002433"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026251394" description="CBM1 domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="4">
        <location>
            <begin position="699"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="4">
        <location>
            <begin position="1182"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="4">
        <location>
            <begin position="1224"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="606"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1089"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="606"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1089"/>
            <end position="1130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0725432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1264" mass="129259" checksum="85AB732E62B36A0B" modified="2020-08-12" version="1">MQVSLIVGAIVAAASTVSASNATTCIESFDLCGAGKKCCEGLTCYEFNDGVAQCLDHKPTKAPKEHTRDAEQSCINVSVVGDATYCVKGPICGDEGDNCPKKGDVASQDCIQTLNSYVEASKCVAPVDATCQKIPSGARGCVFGPIPASTAAPATAAPPAKDCINVSVVGDATYCVKGPICGDEGDNCPKKGDVASQDCIKTLNSYIDANKCVAPLDATCQRIPSGARGCVFGSASASTAAPASTSAPASTSAPAKKDCINVSVVGDATYCVKGPICGDEGDNCPKKGDVASQDCIKTLNSYIDGNKCVAPVDATCQRIPSGARGCVFGSVPASTAAPASTSAPASTASPAKKDCINVSVVGDATYCVKGPICGDEGDNCPKKGDIASQDCIKTLNSYIDANKCVAPVDATCQRIPSGARGCVFGPVPASTAAPSTTSSACINVSVEGDATYCITGKICSGDGSNGVSCPKKGDIAVQDCVKNVRSYVDAAKCVAPEDATCKKLKTGAWGCVWESQSPQKDTKDGDQSCTNVSVVGDATYCVPGPICGDEGSNCPKKGDVASADCIKTLNSYVGGTAKCVAPVDATCQKIPSGARGCVFGPVPASTDAPASTSTTTAAPATTRSTTTSAPGTTVSSSTTATPATTGANNKQCSTNWSQCNGQNWPFGVCCQDPNFQCNKKNEYLSLCEPKDKKRDADVAEVAVWQQCGGVGYKGDTSCTKGNVCKKINDYYSQCQPDRDVAGQPTCVVGDATYCVKGPICGDEGDNCPKKGDVASQDCIKTLNSYIDGNKCVAPVDATCQRIPSGARGCVFGSVPASTAAPASTSAPASTASPAKKDCINVSVVGDATYCVKGPICGDEGDNCPKKGDIASQDCIKTLNSYIDANKCVAPVDATCQRIPSGARGCVFGPVPASTAAPSTTSSACINVSVEGDATYCITGKICSGDGSNGVSCPKKGDIAVQDCVKNVRSYVDAAKCVAPEDATCKKLKTGAWGCVWESQSPQKDTKDGDQSCTNVSVVGDATYCVPGPICGDEGSNCPKKGDVASADCIKTLNSYVGGTAKCVAPVDATCQKIPSGARGCVFGPVPASTDAPASTSTTTAAPATTRSTTTSAPGTTVSSSTTATPATTGANNKQCSTNWSQCNGQNWPFGVCCQDPNFQCNKKNEYLSLCEPKDKKRDADVAEVAVWQQCGGVGYKGDTSCTKGNVCKKINDYYSQCQPDRDVAGQPTWSQCGGKDYSGKTDCRAEDKCQKWNDYYSQCVPNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WHA2</accession>
    <name>A0A6G0WHA2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription initiation factor TFIID subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_015176</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAF10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000213">
        <property type="protein sequence ID" value="KAF0726551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WHA2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020927"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07982">
        <property type="entry name" value="HFD_TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003923">
        <property type="entry name" value="TAF10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03540">
        <property type="entry name" value="TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01443">
        <property type="entry name" value="TFIID30KDSUB"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0726551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="131" mass="14844" checksum="220480030DEC9BD9" modified="2020-08-12" version="1">MEDAQLHEFLDAVGQRFTPSIPDEVVSYFLETAGFSTDDPRIIRMVGLVAQKFVLDVGHDAKLYQQHRLNAHHHPHHKATLTMEDLSASLKELIHADLDQVLGKSPRCDGRKVDKHNSQHLELQQVEGFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WIB2</accession>
    <name>A0A6G0WIB2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_014937</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000204">
        <property type="protein sequence ID" value="KAF0726946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WIB2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002548"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006156"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013011"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
        <property type="entry name" value="FYVE_like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43102:SF2">
        <property type="entry name" value="GAF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43102">
        <property type="entry name" value="SLR1143 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="5">
        <location>
            <begin position="18"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0726946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="571" mass="64709" checksum="3D0917E88EF50F8D" modified="2020-08-12" version="1">MSTKKSIVIRADQLLPRDSQRLRCYVCGRNFTLFRRRHHCEMCGEVVCHDCTLKKTVQVGDNEVTLAKLCISCVLSLSSRQSNQDAIEINYPLDFNWDHPWPKPPTLSQEETRLDVVQSYAILDTPAESAFDIVADLAAREMNCPIAAVRVMDKDRQWLKARIGLTQEEIPRSMSICAHAIFSDKPLVVLDTLKDKRFVKNPLVVGSGMIRFYAGCPILTANGHALGTVFVFDVKPHDSCEVETLQKLAIVAMKHLEDRKTAMLASEPEFGYELDFNWEYTWPKPPVVPFEEERLEDLKSYGILDASADDELQVISHLASDALKCPIVAVSCIADDYQWFLTSVGLAETRKEIPRNVSFCAHTIFSRQTLRDKSSLGMKHIPNAQPAYQPTLQVACAVLDLCLKFRVNREDLLTTGEMVGRIVRQVIPQVLPKDQAARLSSVCTLLGEMHGYLDDDCERTQGWNLLVDESERSTIINEIQSKIAQFQSQHCQCASFLAVDLNVQVIGSVDDLMEDMHSIYFFGDSPFLVCMCILLHWNDQQLIKLSSFSRNTLVRNLMQEVYKREDIRHSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJ50</accession>
    <name>A0A6G0WJ50_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_014758</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000200">
        <property type="protein sequence ID" value="KAF0727230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJ50"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000142"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026215147" description="Transmembrane protein" evidence="3">
        <location>
            <begin position="17"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0727230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="96" mass="10188" checksum="04746428F6ECF209" modified="2020-08-12" version="1">MSRGFALVLAVAVATATNTTGNIDVPEIKAPPARHGGSVAANLLIYGLIAGVVGAVVILAMFVRRARKTKEHEDRAKEFHGQMQLQSQSGNDIHIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJ64</accession>
    <name>A0A6G0WJ64_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Centrosomal protein of 162 kDa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_014544</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CEP162 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000198">
        <property type="protein sequence ID" value="KAF0727282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJ64"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016481"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005879">
        <property type="term" value="C:axonemal microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038774">
        <property type="entry name" value="CEP162-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34031">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 162 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34031:SF1">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 162 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="7 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="236"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="282"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="575"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="645"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="709"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="886"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="970"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1045"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1098"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="74"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="332"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="355"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="382"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0727282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1262" mass="142562" checksum="872405F508F72409" modified="2020-08-12" version="1">MSSDEEFERFLEGDSDDEKSAFTKTLKKAKKKTSKKASKTKEAKTPAIDLDDSADPYNFDMNPPRSSSDDDEKEQLQVKKDKKKEKENRTKEAPKKQSLEDRMAEILKRHGSALAETFAKPQEELSVVPDIKELPKDDEIEVKEAKQEEDASEKSDSYSDSLGMESADFEVGGYAKKTASEKAPTSTPVESKKAPTSSQIESIESSFTLNKTAIEQAPPAAEGFRYASNKSYALENESDDDELIQTSHVKESVLSPPQTNLVPQKADAPFKSDFEKMKELFSLPTELDKADESAYDEDDFEEEHAAPTSDVKSTQKIGPDMYDDDEFEDSDQPPPSPPPSPPPPPPLDLEIISPPMSPGPPPPPPDFELPPSTNLDPAEKSSLPNPETTITSDLKTSMSFLDESFEFNYDLRSKVETIEPPSSNTKHDRTDDVPISAVHEDKNEIVTSTFISKDEGMPYSRSEGSVTVAPKTSQQEFGGADMEGPNPTRIQEVAPFAIQDVSTTSEGNYKMQQGPPPVATRTSIHLNLESHESAAQNPIIAKFHSLQNQLNRSSIGPSESSDSFAQAFERDKYIIRAFSNKENEMKLQLQAAQREILGLRHQVEALSTEQEVHTLSDARLLGKYVQPTSGVQMTNQAWDSMRKEIETQEALIQGYQVENERLMRQLKEVKRDLQYDVHLNNQQLQATIKDLKHQLDTAPSVSSWNLEAQLRADARILSLEEDLHRLQEDRALREKELKQELESVKKAKIDLECRIAGVHMETLHAENEAYESLKARSEAQLREAQDKILSLESKLEWYIQNQRFIDEQDALVKQQQQTISDLKEQLESKPKRMGNKMHRAPADIRRIQALEAQLKEMETAMRKRHPDSLVNLILASKPSPNESKANEQAQLEIQRLKTQIQEMERAHEVKLTKFRQQHERVIQELKEASKPKAQSETTDEGRIRAFYQNKIKELEKKLESLKPPSSESRADKAKIEMEAMEQRHRQREAALQLQLDESENARRMLIEAINSSASNETQVIQPPKMQPAILESLPPPPPLPSSLGDSKLENEVTKLQELMQELKQTHEKAMVDAKALWQDEFLHLSDRFTKAQLEAQTYAQIAARVPHLEEKIQSLTRQLEIPNTPSMLQYQALDMQIQTLQQKHALREAELKVLLQQATQSSKVEVLKLQQQHERAMTTKNEEIRSFQAQTTCYENFKNFDKSQDLSSLTSVNSTVDSSSSSSPSIVKMAFVSFFSGAGYFGVSALSGSNSRYDFLLLCLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WKX8</accession>
    <name>A0A6G0WKX8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_014134</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000185">
        <property type="protein sequence ID" value="KAF0727906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WKX8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005741"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0727906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="88" mass="9830" checksum="8BF8EF8B918B3816" modified="2020-08-12" version="1">MQEVPNITHDDEENLYEEPGAYSGTPKKSFCCTDDIVLLIAANDSKPWSAPSSTLMKAWFDIAAGLKNNRCFGVVKNGQRCKTRLDNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WL54</accession>
    <name>A0A6G0WL54_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VLIG-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_014041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000183">
        <property type="protein sequence ID" value="KAF0728034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WL54"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021377"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021378"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030383">
        <property type="entry name" value="G_VLIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052986">
        <property type="entry name" value="VLIG_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14819:SF25">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_52, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14819">
        <property type="entry name" value="GTP-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25683">
        <property type="entry name" value="URGCP_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51717">
        <property type="entry name" value="G_VLIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VLIG-type G" evidence="1">
        <location>
            <begin position="146"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0728034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="811" mass="93405" checksum="9F5B1FE5B6C321E9" modified="2020-08-12" version="1">MKLRAYETRRTKLRERRRKQSITSNQHVLIRVYRSILQNLSSPGRVIGVLGLGRFLSLSCEEQNARARKAYRQARDAYHDNQTPVNSMMLSRALDEWDKQSVQLEHLCRELAQLCVVDPTTYSGLAMLAAQHLLDGFSLELMDGDAVQVLVLSILGVQSSGKSTLLNYMFGVRLHTSVSRCTRGVNIQLLKCDGRREYEYIILLDTEGILDDEIQSTLSEECYSKWATDQQSHKDDQEAHWRKLVHGQVDNVFRYDTFVAQYKMELRSEANALFGNGRYKHFNEEQITRKFDDIFQRILHYAYDEHPPLHREVPSMVEKVFCATKIRVLSRQDAKKTWSSSRDSEKRETKRTWWNYFFGVKEQPMEKLEATILNSVQDILGTVTQYDDATVLKCIGLTQSMLVDAIDEGKMILTDDYQKRVYYNVKRKICHELQTIQSKCDQKNGVGARFAASRDEMKTYFDNLGKGFQGMRLLQSIVCAWLERNVHQSFLEELVVAVGVVLKDKRWVSDAEVMQAMVDNSLVMLIENNRVDRAIHLIKHPSGHIDDILSELIQFEVHRCYEEKFQQFTKRLIQCIQTSAAKAYEAEKDRSLPTAATNCLLTTIPHTNDGNINCDDQPAEIFDKKDEEFVCWPMIETIEQLSARHRQVDDVSKDVLTFIRSRAHGAASGATPRCGEPCPICMSPCTRELGHVTTEDEKCHDTYHQPTGLTGWKDKLSRELSPGSCVANAEADISFQYTDGEFHPYKNFHKVFPNWSQPIKKQPLLLREYMFRNFQDNLVAMYDGTKICTDIPAEYNHSLQDIKQTISTLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WLH7</accession>
    <name>A0A6G0WLH7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_013967</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000181">
        <property type="protein sequence ID" value="KAF0728141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WLH7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018805"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF91">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PLK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="4"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0728141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="362" mass="40549" checksum="C69145C06E5EF321" modified="2020-08-12" version="1">MDNYVVLRQMAEAIYGQVLLCRDDTTAELVAVKKISMSRAATRQSETHLLHENAIQELEMNHRVQAAGGHGYICRLRDDFYFQDGDDTMLAMVFDYCPRGELLHALSLAKRFDQHAALEYVAQIAQAIDFLHMHEIAHRDISLENVLLTDGHCIQLCDFGLACHATQCTNETVGKLLYMAPEVLAGQTYIPKQADMWSLGVALFTMVVGHYPFHEASMYDAFYSIHARLGLAALLRKHNVAWISPDMQELLGHLLDVDPLNRYTIRHMLAHALVRPCFGQNVEGSLSTVSLENEAAGKECPEQNVPEAPSPPRPVAAAAPIMTIRSPQVVQGQAPLPPRPKTSIRTYLKQKLSHFRIPWTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WMB4</accession>
    <name>A0A6G0WMB4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_013798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000178">
        <property type="protein sequence ID" value="KAF0728435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WMB4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006305"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="1">
        <location>
            <begin position="59"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0728435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="162" mass="18518" checksum="D8646EAC89F4C5D8" modified="2020-08-12" version="1">MLEVRSKFLDEFWVENDHFEDSDVINCNETGIYFDTPPWYILAQKGGDASISHSDKSCRLTAVLAAKRNGDKLPILFVVKGKPGGFIDASELRTYPSGHFYAVQKNAWIDGDGWKFYLDTILRPEIVRPSLILMDNFEAHRMPRNIQYIEEELSSTICTLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WML1</accession>
    <name>A0A6G0WML1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">rRNA biogenesis protein RRP36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_013550</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Associates with 90S and pre-40S pre-ribosomal particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
            <location evidence="1 6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the RRP36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000175">
        <property type="protein sequence ID" value="KAF0728587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WML1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010932"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009292">
        <property type="entry name" value="RRP36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738:SF0">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06102">
        <property type="entry name" value="RRP36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 6" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="16"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="60"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0728587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="227" mass="26822" checksum="7378B06BAC7C6E44" modified="2020-08-12" version="1">MVRSDVRDLTLEERLKLKKNGFAENPRQRDDSSDDDDQDHDTGDEEDEGQPSKKRANKNRPREMTSKRPVGRFREVLQVRKKATRDPRFDNASGKLNEDLFKKSYAFLEEYKEAELNDVKKQLKKAKSATRKAELQQELSKRKQELAEAKRADRIREATLKRKREEREAVESGKGAFYLKRKDKKQLELKAKYDELAESGRLSKFMAKRRKKNANKDHRWLPTQRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WMY0</accession>
    <name>A0A6G0WMY0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_013631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000175">
        <property type="protein sequence ID" value="KAF0728673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WMY0"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0728673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="131" mass="14567" checksum="027C2D6AE897F562" modified="2020-08-12" version="1">MQQGSDGKTRGRGEADADDPSWSFLSSRTEREGIDKPTTKGTRPFASRATRRAVLMEEMTLPEDELAIVEDFHFNAESDEFTPTTVVHANVSVRVLHEDAVANWTFAEALECFQETIQDSDHFNSTCAVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WNL0</accession>
    <name>A0A6G0WNL0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_013255</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000170">
        <property type="protein sequence ID" value="KAF0728953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WNL0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019429"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02799">
        <property type="entry name" value="tRNA_bind_EMAP-II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000225">
        <property type="entry name" value="tyrosine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051270">
        <property type="entry name" value="Tyrosine-tRNA_ligase_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586:SF33">
        <property type="entry name" value="AMINOACYL TRNA SYNTHASE COMPLEX-INTERACTING MULTIFUNCTIONAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586">
        <property type="entry name" value="TRNA-AMINOACYLATION COFACTOR ARC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 3" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="5">
        <location>
            <begin position="54"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="15"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0728953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="220" mass="23876" checksum="A63FD7322A26AF93" modified="2020-08-12" version="1">MVTKVIADLETNLGLAPNEPVEKPKKAANQQPKKEKKAKAAPAAAAAPAEEQAEITKLDIRVGKIVNVWKHETADKLYCEEIDVGEDEPRQIASGLVKHYSLEEMQGRMLLVMCNLKPRNLVGFKSHGMVLCAVSTNEDGSENVAFVEPPADAKIGERVFYDGLTGEPWTPAQVEKKKVLVTAGDGLKSNEEGVAMWNDKVLMTSAGPCTSPSIRNGILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WNL4</accession>
    <name>A0A6G0WNL4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_013350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000171">
        <property type="protein sequence ID" value="KAF0728918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WNL4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010838"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0728918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="133" mass="15044" checksum="C0AC34CD94380F09" modified="2020-08-12" version="1">MLLAPPQARCLPSAATLAAKLPKIHISDEEKQRVSSMRQQSFRRLQSNHLRCAKVLHGNLHWRAVEFMDVGEEQMYIKEEARLREEIEALGKANAAIHASNTALVNASVERRNKRPREPETIKPNVAKTITSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WNR6</accession>
    <name>A0A6G0WNR6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal lipase-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_013273</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000170">
        <property type="protein sequence ID" value="KAF0728972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WNR6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020833"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051218">
        <property type="entry name" value="Sec_MonoDiacylglyc_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856:SF25">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026119122" description="Fungal lipase-type domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="2">
        <location>
            <begin position="102"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0728972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="295" mass="32743" checksum="A9A5784E6735AA9B" modified="2020-08-12" version="1">MFWATAAAVAVASFVLASAAPTRAPVYEYTRTVLDGTSGVYNESHAIYLGRLVSTTYCPKKDVESWTCPPCGNVSKLQNLIVINDKSESFQGILGFTGTHVVVAFRGSMDVKNWVDNLSFLKTRPWPHIFPKAAIHRGFYAVYNSIQDKLFVALSSLFALHPSAPLIITGHSLGSAVAAIAVVDLHTRHNITTEFMLTFGEPRVGNAAFVSRLTHIVRDIHRITHWRDIVPHVPLEWQGYIHEAQEIWYTEDSTSFKLCDPGNGEDPLCSKQVPTISSFADHLVYLNITMSHLIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WNW5</accession>
    <name>A0A6G0WNW5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MINDY deubiquitinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_013319</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000170">
        <property type="protein sequence ID" value="KAF0729020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WNW5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001988"/>
    <dbReference type="OrthoDB" id="10261212at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016807">
        <property type="term" value="F:cysteine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990380">
        <property type="term" value="F:K48-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007518">
        <property type="entry name" value="MINDY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033979">
        <property type="entry name" value="MINDY_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18063">
        <property type="entry name" value="NF-E2 INDUCIBLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18063:SF6">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04424">
        <property type="entry name" value="MINDY_DUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MINDY deubiquitinase" evidence="2">
        <location>
            <begin position="40"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="416"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0729020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="448" mass="51142" checksum="1962EC7804B31680" modified="2020-08-12" version="1">MGGEDDMKPMPPPIEEIEPKEATVAPLSPSKRSPKQEELVYWVKETTFLQRNVHYICQNINGPCPLLAICNVLLLRGHVTIDPFIRMVAAQKFIYARDVVYVVETRLRAANSHFNEIERATLNEVIALLQTLQVGLDVNVQFHDVGAFEYTSACAIFDLLDMRLVHGWVVDPQDEASHRVLAGKSYNHIIERLIDYHGVLETKEESVTTLMKERSLSMEQAALKVEQITQEGPIIDRFLNENASQLTFAGLVSLHEQLKERELAVFFRNNHFATIFKWQGHLYLLATDAGYYDEPNVIWEKLDEIAGDSEYYTATFTRLVASDTKQQEIESQPAAAMAVALEPKPQETENDDFALALRLQQEEDDAAIALAQEREMAAKVEEVQVDPLAMTSEELEMQRQAERYYNQRLLEHQQGYRPEQTQQQPYYTTSRSNPRTSASDSDRNCALM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WP46</accession>
    <name>A0A6G0WP46_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">X8 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_013133</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000167">
        <property type="protein sequence ID" value="KAF0729155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WP46"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011570"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012946">
        <property type="entry name" value="X8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF38">
        <property type="entry name" value="X8 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07983">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00768">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026185864" description="X8 domain-containing protein" evidence="6">
        <location>
            <begin position="20"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="644"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="X8" evidence="7">
        <location>
            <begin position="538"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0729155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="693" mass="76742" checksum="D3BEC125135ECB5C" modified="2020-08-12" version="1">MKGIGGALSVLLAAAVAVAPPTEKPAPAATTAKPAPTKAPSTPVDFRDFVAHDDTQTCSQDKHSTPFNMQVRGVNLGGWLVLEPWLTPSLFYQFLGTQERFGDKAPEKTGMDQYTFCTALGKQEANRQLRIHWNQWVTEKDIAELVSYGINSLRIPVGDWMFTPYEPYIGCTDGAVEHLDRVLDLCKKYKINALIDIHGHIGSQNGFDNSGRSHQVKWTSLASTQPVGTTTFEHWPIRYAEWAGTFDPVSHKYSSINYTNLNQSLEAVSRIVKRYASHPAVLGLQPVNEPWELTPIDVLKNFYWESYKRIKSLAPSWKFVLHDSFRFGLQFWQDFMKGCPDIALDTHIYQAWMNPSTAEDYGSNACQQKYTISNMENALMPVIVGEWSLATDNCAMWLNGFNDNLPGFPKVQCTMQKCPVDSTYLGYGFPGTPLDTTKPIQGPYGTGTSGPSFGLCPVSKNDSFPGISHRDFTTKLARKKLNGFQVGHGWYFWNFKTELDFTWDFLQLARAGVFPKNVSKYEPDEVDNACIAEDKGAFVCQAKRGVKDIELLNGLAYACNSGVDCSNINEKYQTLVEKCDYAYNAYWHKQRENGATCDFGGSAHLVSVGSDSPESESRPDYVWTGSGISGSDPVSNHETSGNSWVVSGGFVVGGLCGVLVTLAILSWQKRKNEQAGSTAGERLPLMSTTTASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WPL5</accession>
    <name>A0A6G0WPL5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator complex subunit 15 KIX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_013043</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000166">
        <property type="protein sequence ID" value="KAF0729297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WPL5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020282"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.20">
        <property type="entry name" value="Coactivator CBP, KIX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036529">
        <property type="entry name" value="KIX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036546">
        <property type="entry name" value="MED15_KIX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16987">
        <property type="entry name" value="KIX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mediator complex subunit 15 KIX" evidence="4">
        <location>
            <begin position="2"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="119"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="119"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0729297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="184" mass="20420" checksum="3369E1D2A7441A32" modified="2020-08-12" version="1">MRKTMITEMYHELLRISGESDRQKVWQSAAKFELTLWTQSTEKNVYLTKLQKKIATLKKKPNSGEAAQPAVAPAPIQQTQPAAFQTQANNMAYLEMLKKQQEQQQIAAMNLTRQQAQAQAQAQAQAQAQAQAQAQAQAQAKAQAAAAAAAAEKQRKEQLLEQQRLLRQQQAAAAARSQGSIERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WPW5</accession>
    <name>A0A6G0WPW5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_012905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000164">
        <property type="protein sequence ID" value="KAF0729404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WPW5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013300"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0729404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="36673" checksum="5C69749A879AC11B" modified="2020-08-12" version="1">MLTSDDTPRLKETIRKRKYRAGKRRELIDLEAQARRLEAYLAKLQTQHRWVYVNEHPQKMLSNRPTWMESTLLAHPITRRQGIQWLSERIFHQACRTVPRDRSLRGQGDKVYTLDVHVSDDIDDEGVTIDALETRYERTEYMDGKRAADEHWERLLSTQPTITKELIEHMDDRFMYFHHINHRIGTHILTIAGMLQDDDRVVITSCFVAKDELFPHGENIMRLHGFAWTIFESLAPYITLVHNLSYHYTPTLSNGRVIPLEKIGQLFGRSSFGSKHREAYIELIRSTAEAAFIDSHNEIDRQMKARKQRASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WRI1</accession>
    <name>A0A6G0WRI1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA polymerase delta subunit OB-fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_012463</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase delta/II small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000157">
        <property type="protein sequence ID" value="KAF0730065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WRI1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012344"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07387">
        <property type="entry name" value="MPP_PolD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040663">
        <property type="entry name" value="DNA_pol_D_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024826">
        <property type="entry name" value="DNA_pol_delta/II_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041863">
        <property type="entry name" value="PolD2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416:SF0">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18018">
        <property type="entry name" value="DNA_pol_D_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase delta subunit OB-fold" evidence="6">
        <location>
            <begin position="34"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="5">
        <location>
            <begin position="180"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0730065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="429" mass="46592" checksum="2DE85D789930E0FD" modified="2020-08-12" version="1">MGDDASSFPLRRKSAACEYEHQRFVLKKKSYDQQYSHMYVSRLRALEPVVRAHVEKGGLPILPKIIDLKPGDPCVIIGTIFKSLAKKPNILDEFVADEVLVLQESSTCLASDDDQLVLEDESGRIALYGDIRVQEVVTGVVVGLQGEMRPGGDGFHVSRVCTPGIPPQSSLPARSDDAYVALVSGIQMGSEACDPVKTSLMIDYLAGRIGNADEKNFVQSIVRTIVIGNTLGKSTKDNTLPKASATAIAQPLEHIDALLSTLTTTMPVDIMPGAFDPSNFTLPQQPLATCLFPRSMYTTACHVITNPCQLSVDQVRFFGTSGQNIDSIGMSCTGLSPIQGLSAMLDWRHLAPTAPDILACYPMPQEDLFVIEEAPHVFFAGNQPQFESHVVEGENKQSIRVVCVPSFAETGVVVLVNLRDLSCLPLTFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WRM4</accession>
    <name>A0A6G0WRM4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_012460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000157">
        <property type="protein sequence ID" value="KAF0730062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WRM4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012347"/>
    <dbReference type="OrthoDB" id="10276462at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0730062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="102" mass="11626" checksum="6B2E447404FA7BEE" modified="2020-08-12" version="1">MRFETVPPAKTASNQPTSPPIDVSMSSFQLEMDCRRGQESSQTSSEDVGQSLRGFFSLDDQAHEILEEMKWRKTQTPQTPRRILLRVRSPSLGSIEENQQDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WSV9</accession>
    <name>A0A6G0WSV9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PB1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_011938</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000153">
        <property type="protein sequence ID" value="KAF0730515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WSV9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015882"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05992">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PB1" evidence="2">
        <location>
            <begin position="5"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="104"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0730515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="389" mass="41985" checksum="3BDEEAA967DE6133" modified="2020-08-12" version="1">MEQNMTAIKIGYKGEIHRIRVDLTAFKFGDLEALFEATFNLTRDSFVVQYKDGEGDVVNVKSTEEYEEACRLFTAATDSAKSLRFTAVPTTQVVFQQNVAEPILKVIEQLVQSLNEAMEKVKREQWAAKAQENARAFATKAQENAGEWASQAQVNAGVWSVKAQEAMASTGAVLNEQFSKTGDVLSEKLAQTSTVVNEKLAEAGAALAPIANKTVEESKAAFEAAKKSLNDIEFDKIKQALNEIEIDRLMKDASDGVKSAADVAAAYAQNLVNELNKLKQHTATDAVVVETPVAVPVAAPVDEVVEAAPAEPTVQVVVQQAAAETPAEAEWEEVQDETSAAPSPEESKWAAQLALVREVFPDANTAAVIDLLEAAKGDVHVVLNQLVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WT87</accession>
    <name>A0A6G0WT87_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="14">3.2.1.58</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Exo-1,3-beta-glucanase D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Ae201684_012075</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Glucosidase involved in the degradation of cellulosic biomass. Active on lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="14"/>
    <dbReference type="EMBL" id="VJMJ01000153">
        <property type="protein sequence ID" value="KAF0730656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WT87"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011715"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF34">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026197439" description="glucan 1,3-beta-glucosidase" evidence="16">
        <location>
            <begin position="18"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="17">
        <location>
            <begin position="496"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF0730656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="679" mass="75511" checksum="2DDB5C573AE5D823" modified="2020-08-12" version="1">MTKCVFALLLVASFALAGHIQAQIRAGKAPARGVNLGGWLVAEKWINRMDNLWRSADQNDAQGSDEYFMMKSLGQVKGQALFDAHWSSFITEDDLKLIAAAKFNMVRVPVGYWIQGCNDTYIQQFPDLQAHCGVFPKGGWVYLDNLVRRWAPKYNVAVMVDVHGVPGSQNGAEHSGEGGNSTWSDFPEYVQVTRNFVNYVVDQFKDEPAFLGVDLLNEPSNFVFDGVGGVDFNVMSKYYLDTIRDVRAKSDCILVTEPFLGNQAPGNGFNMEDFALNFTNVWHEWHPYLSFSDLNAGQFLAAIDDYKQSNLKWTGNPLFLGEWSLATQVDPVNMAKFVQAYITMVGTAKAGWAAWTWRADSLGVWSMKSTLDLDNPDAVTSDSSSSTFPIYSSADKSVSPGSDWRLVDTPAWIDQLGRSPEWSLNSRTGQLVNNRHGRCLASRTTKKKSVVVFETCSEKSIDQHWQLGNHSVFSRSYNKCLTSSYALEECDSSKLTQYFVIGRERSLLFLENQATNVGVTSKNAVVFGVSDTWLIDHETLSLQHETSGKCLEGNDTPDAVQLVECDQYIPAQRWKYDATTRQFHHSSGNCLSYCSSKDCQTTQLMLTKCHQAKEATIASQQFRLVWQNYPDLVMATVNGTVAPGSAGFQPEKRPSGSPSVHKLCSIGVLLLLVAAINLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WTS0</accession>
    <name>A0A6G0WTS0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_011795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000149">
        <property type="protein sequence ID" value="KAF0730913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WTS0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007818"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008996"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0730913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="665" mass="73851" checksum="AE997721E0EE0E54" modified="2020-08-12" version="1">MSDSDSQRRSQSPDNAPDNRSRSREQQRGRPLRRQVPTPFRSPPRRNPPPVDQRVVFGGYVYQPPATAAPTPTAAPNVSPSNSTPGRAQNTPLPADSADDVDMGDDDGSTFVYNAPALPQPPTFNGSTKAERRIFIRQYNKYLDQINALHCNGTRPFVMPVSACMDVSTKKRLAMWTFGNRDYRTIEESEWEAWFGKAFDEEPQDLEVLKKRLTSAIRFNTSILDADSRIEKMLEDLMKALERDDQTWILEQEGKIVVDIMVKIKPTTLQKSVVRQLAMNRNKPLKSDVFRFVGWLRVHTAGYQLYGPADEEKPPAPPKNTKIEKSNDSGGGGANRGTPANDQRGAMPASPKPKCLKCGKDDHKVSACPKCAPGEADKLLKEQLEKWEEARKKVAKLNQPVHQSLGREAKIEDIVSVSTTLLDTGSDVTLVTAGVITSLEDAGVDVTNVSAEAIEIQPYGQAAALKLDRQVQFNLVTLETPCGPLALRGLKAWVDNTSNATELLISRAVMERLGFSEDDFLCHAFAKQEVWDVSDVDKPSDFARIHRLTHAAVSDECGDDGINCATPDIQVPSPEDADTERDRRRAVVEAVLEDKIQESKPEGLSAAFLERLRKILTTHVDVFRLEIGHDKPIAMEPLRVRIKPGAIPVKCGLRRYPPAHVEFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WUS0</accession>
    <name>A0A6G0WUS0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_011473</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000146">
        <property type="protein sequence ID" value="KAF0731212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WUS0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009811"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF5">
        <property type="entry name" value="TR-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="Initiation factor IF2/eIF5b, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="6">
        <location>
            <begin position="114"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0731212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="506" mass="55336" checksum="47B4784ED0CED424" modified="2020-08-12" version="1">MLSQLVRWHGRPPLASRAFASKPKKPVVLSNFTRVRDLAKKLKVSADAVVKHACTKHYHKYYMTHDNVKYKFDTLKQVVLPLDVAARIAAHFDVPAVYDPIEMPDLQDRTPRAPRPPVIAVMGHVDHGKTTLMDSLRGTDIAKHEVEGITQKIHVCDTELAPGVPATFLDTPGHFHFTRMRNNAAGVADVVVLVVAADEGCQLQTEESIGCIEELGVPSVVCINKMDLVSSSKLALERVTEQVREFVAMDTSPVVPISAKTSLNLDTLKETLLEVLQDVRLEAYHGDDGGQGTALEVVASTGLGTVLRILVLNGVVRPGDHFICGMIHGAVKTIRRANGDVVVDGATPGHVVDVTFKNLSRHKDAPLEFGFHVLDKERCEAYIEQREMANDFAASVDPADMPQDDQEELPLKGFQGTPIVVKADTAGSLTSLLDTIDEIPGIHTAHVGLGAVTVNDIERGCTIFGFNVKVHSRERKLAAERNVPIVLRPTIHQLLEEISLVQDVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WVG3</accession>
    <name>A0A6G0WVG3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_011142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000141">
        <property type="protein sequence ID" value="KAF0731516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WVG3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007388"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052394">
        <property type="entry name" value="LRR-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0731516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="944" mass="103804" checksum="45C2616E0303809B" modified="2020-08-12" version="1">MTDEENTTPLLKQDSSDGKSGVPTSNLSSDVTPTPVADKLQSSQSLPAEPEVSDSKEVQEVSSHEANVCIGEHNDDKTKTDTAGKGLATNPPASLNEINITNAIQKRVRFADEKPATPSFMARRIHFKSAKLTTARRFPWTKVVVSPPPMSDNEAMTMELALKLPPDPPLLTFKEHLSLGMYWSKHVKLLRRNDKQSPLTLKIGKKKLDVKQWAIVMTMAVAYNTTLMDIDVQGAGIDSMAAKTLFQAVRANHSLLTLNASKNHICDDAMFALAAMVQTNTTLTRLSLHANMITSKGMKLLGHALEENQDSMLLDLDLSLNPLGEDSTEDFFNCLQINETLTALNLADTNIHEAGVLAALRRNYTLVSLQLQRIPPVKKTNQSGQLPRDRLNRSHAPPLMDALRRSTCALEECNLTGVTLPISKFKTSRWVKLPQFSLNELDGMIISALLPANKQLLELDLSHNALGSDSVIAIVAVIIECPTLKTVEIQDNDITDISGEAIGLALANNTTLETIRVAVCTLDVQQLRGNDTSEFLTFAKDLFAHPLDNWIVTVLMGVNRRTQVLNDLHVPPLDAHLDLCHLTLQVYEAVYICTRVRHHVHMTHLFINSSHLDYYAGMRLADAIRNHSVLKFVSLEHNNLHQMGGNAIAEAMEHNTSITYLNLSWNQLDDAGVQPFATSLSANRCLKRLDLRGNSIGASGIAAISQGLAGNGCLEELFLRWNDIGPNAAISLANALCINKTLSVLDIEQQHMETQGAFAMAAMLCKNKSLKSLNMKGDLKLYPTSGIGMQGAERLAAALRDNNQTLTHLNVSETRMKADGCEYFAQVMTTLHLKKLDLAFVELDGETSLVLFAQLAHNTTLELNASHNTIGADGIKGCVRCLCVNKTLREVDLSFNQITEEGMLLIEAQAKQFSLNRLRLLGNRVTDGTRERLASMQLSLVIDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WX95</accession>
    <name>A0A6G0WX95_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Actin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_010770</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the actin family. ARP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000137">
        <property type="protein sequence ID" value="KAF0732118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001419"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10216">
        <property type="entry name" value="ASKHA_NBD_Arp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000502">
        <property type="entry name" value="Actin-Related Proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000008">
        <property type="entry name" value="alpha-centractin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0732118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1380" mass="154753" checksum="CA431C12B4AE30C2" modified="2020-08-12" version="1">MSKILNALAAERNAIVDGYIQRTQVQSDLEKFWAKLTAMIFLPQNPYPTAIDYFRELEASRNAIVAPPPGIVELLNMSYSTIRMASVDGIFGNSSLLKHINPQAVRRMVDLFDFEFFKQWNEDGYAVTSACALVNLAVFHGTSLIPKLNNEIELEHHVVIEGEKLERAIAIFATILAKDAYASQTSHATLSVGVWVSVPSFKKSDTDTKKLWTLDGIQTSRAAFVSAVKTAVAARTPCYISEFRCRQQMGYHGNIHAPYSAFVKVTRTFIMHFKPQTESKSMRSFASQPQRALCEGLFFTQDAVATLVSALRENSPTTLSWGEYTTPVLSSFTCGDLFVMSRALLHYSGVSQDSSKTLAQLCQITGGLPGELHALTETSANFKELLLLFIENPTGYGSCVPALSEAMGQYTYEVRQIARSHVHSLFAGLSKAIEAKLVHLVLPDDVDLTRFEYLIDQYKQIELLLVYVTQCLTRYILKTMHQDTVENPVYVVNQLVRTAQDEAKKRQQQIDKKAKTKKATETPEVTGKFVDPFEAPPFELGVSITREQEDAIENEIYPLEVSKQVTILQYIVDTRLDTAFETAMTSIVLNGMPSNFYPSIVEHLRVFGVRHVLSLEPKVAPIPFTIHGDFDQVIEHHGAFGTGLALAFVPDSVQNTVLQLKSWPICKVNYASPSANFTVQTGTSLYLRRWYRFYRGEPRHVDVVEHIQVETAHPSARKSIELFSDAVLQDVLNLADQKHMAVIWFRVASSQPERPHFKLNSVDMKRQREVVRIKIEDGVRQRHWIQACVYFQNKLVVKSYVLHLTDGAVKRCFAPTNLNFAHSQIYSTMADAENCQIHANNDSDIVDEGELDILDTYDDKLRESILKRDIASCEPSVRLLFKSHVLTLKRIEDQGQVFAAVCMTHLAEVKEELDKWLGQVQALVDLPEFHYALTIFGMWKASLERAIAAKVGGDVLNMTCIKLYKKHDGNQKLSPRILSGSATTFTSQDIVRMAEYNQPVVVDNGSGVLKAGFAGGELPQAVFPSYVGTTKHLRMMAGGAYESGDTFVGSRVQQHRGLFTIKYAMEHGIVTDWDRMQRIWEHMYSKDMLNITSEEHPVLLTEAPLNPAANRVKAAEVFFESFNVPAFFVSPQAVLSLYASGRTTGVVLDVGDGVTHVVPVYESFTLPHAITRMDVAGRDVTNYLQLLCRRAGYNFQTSAELEVVKEIKEKMCYLAFNPAKEEQLMQTNLHLADSSALPQSQSSEYRLPDGNVLYLGPEKFRAPEILFRPELIGSEHTGVHDCLLQAILRADLDLRKTLFSQIILSGGSTLFPGFGDRLLSEVRKRAPKDIKIRISAPPARQYSTWIGGSILASLATFKTMWITKAEYEEHGASIVHRKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WXR7</accession>
    <name>A0A6G0WXR7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_010569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000135">
        <property type="protein sequence ID" value="KAF0732278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WXR7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000323"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044294">
        <property type="entry name" value="Lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482:SF62">
        <property type="entry name" value="LIPASE ROG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482">
        <property type="entry name" value="LIPASE ROG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF676" evidence="1">
        <location>
            <begin position="74"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0732278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="413" mass="46686" checksum="3C3EA7DC25EA18BE" modified="2020-08-12" version="1">MSSLDETSTPAMDSEARKCDEEHLAVQMRQTEKNRDLVANTSILVDLWGARLESLRVARRDEPETSNAMKKELPSHIFILVHGNNGAPSDFDAIASRVRTAFGGDCFILQSQVNQGPMTRRGIARCGTELSIEILDQLLQFDVTPSPHRWLTIVGHSFGGLLARYCLPYIEDTFCSLGIELTSFATLCTPHLGSRRPGGSVWKELVKCVVHGVLSYKSRYGQTGMDLLLEGEPDSMLEQMSRPDSIFMRSLAKFRHRTLVGLVDGDHLVPRASSCLIHVHPNIVLREESLYCWSVGHSGFPDSFEVLANFDKVDMALLKDKEQCYTRHGIEHDLQQRVAIPQTILKGLESLSWRRLHVRVNYNQRYWLKMHDWPMALHQPPHTRCEEFVDLFVALLVADHNAISTEAVELVDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WY28</accession>
    <name>A0A6G0WY28_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_010399</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
            <orientation evidence="1">Nucleoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NEMP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000131">
        <property type="protein sequence ID" value="KAF0732502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WY28"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021591"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019358">
        <property type="entry name" value="NEMP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13598">
        <property type="entry name" value="AT07567P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13598:SF1">
        <property type="entry name" value="AT07567P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10225">
        <property type="entry name" value="NEMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026197440" evidence="9">
        <location>
            <begin position="23"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="365"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="447"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0732502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="556" mass="63448" checksum="400B58D7EFEA384F" modified="2020-08-12" version="1">MLTQVILPVLVALCSSLMYLAATTPSGESWNALWIQEAESKHANVSWMQDGAQETIQFENFGQSKSFCFLPNSTLPFRIDSLNDPRQPYIVQWLSEFKELDSYFEPVAPFFFKLQHAVTMIQPLIWGWSDLRIAISSESKSNLAFMYKTPTSHLCQILDHIQLTAYPHIREGLPDFLLYVLSKGGELTKKYCEGCSNGCQMACEEMANNPDTCIATLSPYQYPCVTVFGPETGILASQAKTPFTITFFSVISLKYVQNLVVGYILYFFSTGLARSRLFHYFLGATIGIVCSVALLLYQLYKQSQSTLRLLPGAGFLQSASLLTTVAFPVTGLMLLPTLYSILQWALGLLFMFWRSEEVLGIPHLGKFYFLFFGLVGMVLVWWFQWWAPSSNQTANEAIDDVDDDGVLEDIRRMESEDAELPDNQMRLCRALRIFAIMLLFQSTSSTLQSWLIVLVALLWSFLEALYAHVYYWFWSETPGLHSTLITPQEYAAQATSETEKALAELRRYLNEHPDVAESVREDNEVRLRRFMHGRGHMETTPQVRVPPRNQRWCCIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WY54</accession>
    <name>A0A6G0WY54_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_010464</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000132">
        <property type="protein sequence ID" value="KAF0732475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WY54"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013788"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="189"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0732475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="733" mass="81311" checksum="B5BD405540AE9533" modified="2020-08-12" version="1">MQNPRQNQEDPHGGNADRPSCRVTARQQEWAEFFDMNPLQRFIQNTLHGVAQAPPHDENSNQDDEHGETLTMEVDMPPLATPAAAPSTPTDHSAMDVCLESIEIKGLTPSIYQPPPTAYMPHHCGEEPLQMQRRFVRDKLWTLRTMKQRLRVVPSDFFSTQLVLHRDAIDRVPWPYGGLVHLGGVESLVMDFLTASELVTGSLVCRRWSGLCRHDGLWEKFLVSPVEHYPLRRLLSCPPSIPAIQVYMLFSTSALATGPIFGQAFDALEDESTATASTVPLTAASKDHLRNLETMRVESVHIRRVELPRAKRIDKMFNPTTFSFRGGESLKSYLVKHAPLPPLVLKSFAHQLLHACVALEKAGLKHTDISTKNIVVHAIPPTSLNESTSGTSGIGAASVPLLQLDGHYCLEKISTATTTTTEDQDEALFWTIMYDPRNRDGGGGGGNQLVKHMLCGYMYCVLDMALEGRSANLRQHSLMYCMNVDRQYLARELRSLLECAAYLLYTKAPLASLLHHPYFQPVFPPPHVPALVARGSMTEAFHPYTMDLTPLGNGSDNVSYMTQVNAWYTEALPKIVELYPIHAFASVPTSMLGMDMLHGDVGELQLVRTRYNCIAAPMTATSNWMKILASSQRLSLKRLDLSRLELSSSTILQGLSLLPYVMELKLPKAMLREANLEHVISAFANGLLPSLTTVEEAFCVALTKMEASYTSQLDMVDFLLQGSSGSATSSGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WY57</accession>
    <name>A0A6G0WY57_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_010434</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000132">
        <property type="protein sequence ID" value="KAF0732444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WY57"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004778"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026090978" evidence="2">
        <location>
            <begin position="19"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0732444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="306" mass="32610" checksum="17FEB1B361B59E1B" modified="2020-08-12" version="1">MRSLLIFAAACATAIAAAADAATAALPRCTLDDVATLKLAIHDQPLRAACEADIGSSLDAVERGVLSLEQADAFANSSTCKELFQTVQTKVDVPCLEFHNYLPRVSWDMVSQLVHVVGYPPAANDCDLGALQFAGMSLSISSSLYPCLAATGLASNYMTHSTPVAAQWQAADKTPACHSLFGQAQDVVMRFPACNIQGINIHAAERVSFPTAIQWVELATDMQREVPDLFVLKEGSSILSKDRGSIQAKDKTAATRDATSIVTTTSSGVWWLVATVVVLCAGLFASRLFKSRSAASAEEKRLLSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WZ52</accession>
    <name>A0A6G0WZ52_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_010200</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cAMP-dependent kinase regulatory chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000128">
        <property type="protein sequence ID" value="KAF0732876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WZ52"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018937"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004862">
        <property type="term" value="F:cAMP-dependent protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034236">
        <property type="term" value="F:protein kinase A catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050503">
        <property type="entry name" value="cAMP-dep_PK_reg_su-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012198">
        <property type="entry name" value="cAMP_dep_PK_reg_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635:SF152">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000548">
        <property type="entry name" value="PK_regulatory"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00103">
        <property type="entry name" value="CAMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0114">cAMP</keyword>
    <keyword evidence="3 7" id="KW-0116">cAMP-binding</keyword>
    <keyword evidence="5 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="9">
        <location>
            <begin position="77"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="9">
        <location>
            <begin position="199"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000548-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0732876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="320" mass="36324" checksum="1508FAB9F982734B" modified="2020-08-12" version="1">MPSVDQDSKHYESDHTGEDDDDDDNNSNSPRGPRLTARRNTVMAMPLELERDWRPPQFNKSASERADIRQAIGHNCLFLNVDDTERSILIDAMERFQFKKDAVIIRQGDEGDRFFVLAQGTADIFIDDQCVGCLEADTTSNYCGELALLYDSPRAATIKASSDEVVAWALDRVTFKKVLMDTTIKQRKLYEAFVHEVPILSELTKYERLTLVDALKPVFYEQGQVILQEGSSSDDFYIIADGEVQCTQQGEEVSRRLGSGDYFGEIALLRDEVRQATVTAVKDSTVLVVDRNTFKRLLGPLESHLTHNATLYNQYVRHRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WZS6</accession>
    <name>A0A6G0WZS6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_009900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000126">
        <property type="protein sequence ID" value="KAF0733078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WZS6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019103"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000085">
        <property type="entry name" value="Dihydroflavonol reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="22"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0733078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="291" mass="31999" checksum="27521D88CFA2C80C" modified="2020-08-12" version="1">MMHIKSDVNFTLELSSDMAKTVLVTGATGFIASHTIQQLLAKTDYVVRGTVRSLKKPDRFAHLTSLPHANTRLELVEANLLDDKAWAPAVKDCAAVLHIASPFLLTLHDPQKDLVEPAERGTENVLRAAIAEDSVKDIVLTSSLAAIADAPVDGKVFTEADWNTLSSLTRNPYCYSKVRGEQKAWELLKNVSDKRLVVLNPFLVTGPSLTKTINPSVGTFVDMFNGKVPAMANLSMGFVDVWDVAWAHVLALTNPNAKGRHILCNEVQSMQQVVETLRTKFPNAKYLVYCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X046</accession>
    <name>A0A6G0X046_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_009801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000124">
        <property type="protein sequence ID" value="KAF0733237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X046"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005381"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015394"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="316"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="537"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0733237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="589" mass="65569" checksum="903B9E0684596ACF" modified="2020-08-12" version="1">MLSFLGLTSTASPAKPTSAPPQQTTQKQEQKNANPHSAQQHKTQVKPVTPQQQSTKQDQKHAKTQDNKQHQSKQQKNAKAVGPTKQTETPKQNQTSKAAPVQQPTKTKSMTPAQQLEMQQILNILIDEDWNDKTNKQPQPTPKQAQKTPKAPKPQDVKASKVSPKSTKSTTPVQQVPKTALTRKVSMTPAQLQEQKEIPHILIDEDWTPPAKKAQTNQKPTTRPGSAQTKQNTPAKTATTQSPPATQKKTQTHSKLSLSPAQQLEMQQILNILIDDAGKDWKPRNKTVKPHTKQPHQNPPTRPTSAKPRQTTQKATTPSPRPQTTSTPRPVPKMTLTPAQQVEMQQILNILIDDAGKDWKPRNKKPHDMTKIKKHGAKPTSFASKQKTPAQKTSPQSKPVAKKNTVSKVKAPTKSSVVKPDKPLHRRRSLTDAQKREKRAIMEILLEPYEYVPAPVRPRSSTVQLHAELDHKVGNVVVVSNQPVDASEDLSGFETVKSRHTTFQEKKEFRQEIGDMMSILIDWTEPLPKKQAKQTPKKATPQKTLTKTQTRTKPRSKNLSIPPPRIFKETRISLSCRSSGASGGGSRSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X1B3</accession>
    <name>A0A6G0X1B3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-dehydrosphinganine reductase</fullName>
            <ecNumber evidence="9">1.1.1.102</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_009514</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.102" evidence="9"/>
    <dbReference type="EMBL" id="VJMJ01000121">
        <property type="protein sequence ID" value="KAF0733578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X1B3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002967"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047560">
        <property type="term" value="F:3-dehydrosphinganine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006666">
        <property type="term" value="P:3-keto-sphinganine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08939">
        <property type="entry name" value="KDSR-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000468">
        <property type="entry name" value="Short-chain dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045022">
        <property type="entry name" value="KDSR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550:SF3">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="294"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Ketoreductase" evidence="11">
        <location>
            <begin position="40"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0733578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="328" mass="35024" checksum="4B64A2E5A14DBC1A" modified="2020-08-12" version="1">MVHVVFEVLFLVLAVPLAGTILVAALTPIFSRRKINFSGKHVFITGGSEGLGRAIALQLVEAGADVTIVARRAEVLQTVVDEATKSSSSSHGRIFFQTADVTKPDAIQKAVDDAQAAVGPIHILIPCAGKALTGYMKDHTIEVHRRAMDLNYFGTLNTVNAVLPTLRQRQQGTICFVTSGAAMTSYVGYSAYSPSKYAVRGLADCLRNELTGTGVSVHIAFPGGMDTPGYADEMRAKPEECKAIEASDTLYKPEAVAKSILKDLSTGAYNIYCGDIGINLLGILGAGMSPRKNPALDVLLFPIAVIAGFFVRGDWAKHVENGNKKRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X1Z1</accession>
    <name>A0A6G0X1Z1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transmembrane protein 198</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_009441</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM198 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000119">
        <property type="protein sequence ID" value="KAF0733883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X1Z1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001457"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025256">
        <property type="entry name" value="TM7S3/TM198-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040236">
        <property type="entry name" value="TMEM198"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31247:SF5">
        <property type="entry name" value="DUF4203 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31247">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 198 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13886">
        <property type="entry name" value="TM7S3_TM198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="TM7S3/TM198-like" evidence="8">
        <location>
            <begin position="95"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0733883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="329" mass="36074" checksum="BE991725401A3230" modified="2020-08-12" version="1">MCPPRPGAVPARILNFKGNVEVLPEKVIPRFSPHYSTNNMKNRISIALLALTLLFQCFAMAETAAQAAAASDFDDSVHDLFESAKGIKVGPSVVAVIAIVTGLLVALWGYKLFRPVMFICGFATGAVLGYMLAERIFGNKDYFTTAAWIMFVAVGLIVGVIVMNIWTLGVFACGAAAGVLLGFHVNTSFGYLIYPSSPETSLWICVIVLGLICGFAAVWFERPTLIIATSFFGATATVWGIGYFAGKYPNSVELEQWRTQAANGDYTYNIPNAWWYYLAGTFVFFLLAMYFQFNNSALGVFHQNPRKKNAQQEQYMAATPTRGNPISHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X2N6</accession>
    <name>A0A6G0X2N6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_009031</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Orai family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000117">
        <property type="protein sequence ID" value="KAF0734163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X2N6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013929"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.140">
        <property type="entry name" value="Calcium release-activated calcium channel protein Orai"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012446">
        <property type="entry name" value="CRAC_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038350">
        <property type="entry name" value="Orai_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31501">
        <property type="entry name" value="CALCIUM RELEASE-ACTIVATED CALCIUM CHANNEL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31501:SF7">
        <property type="entry name" value="CALCIUM RELEASE-ACTIVATED CALCIUM CHANNEL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07856">
        <property type="entry name" value="Orai-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="258"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0734163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="277" mass="31746" checksum="4DE3E8A94E820149" modified="2020-08-12" version="1">MASGVVLSMLGSYDLNKAQQWRTDDLQHRAQECQWRWDDLHRAHSWRRADVEREKRQNKLVNELRLSDARSDQLSTVSNMSVLLAGFAMAANVEISLPAPSQVPQLLIFVYGTTSAAAILCMLCCMLMCTMLLLALTQFTSHELEGELRALQESDLDKVSPLCQWWLKRCEHDWRQAYRLFRVGVLLFIITVVWVGWVQFHKSQYACIGTTVTAMCVFAFWSLRVESKWKYLFHATERRAKSMPKSKIYRIELRKPSTRPSVASTASTGTSLPPPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X435</accession>
    <name>A0A6G0X435_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Lysine transporter LysE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_008693</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000108">
        <property type="protein sequence ID" value="KAF0734682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X435"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016150"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001123">
        <property type="entry name" value="LeuE-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30086">
        <property type="entry name" value="ARGININE EXPORTER PROTEIN ARGO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30086:SF20">
        <property type="entry name" value="ARGININE EXPORTER PROTEIN ARGO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01810">
        <property type="entry name" value="LysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0734682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="35251" checksum="7FD2DD97936FBC3F" modified="2020-08-12" version="1">MLPLYKKGLTYITVKRRHRNVVLIAAIATVVICLMLVGTYTMYRPLDTSAEETIAPASTTTVSPAVVIPEMIPRIPNIPSLSSIPATTDAPIPSPEETTAHNLWGLRYLLPISAGFIFGFLGSIPIAGPTSAMVLKMGIQGKYWEAQTVALGGAAAEATYAGVAYWGFGSFLVGVGFLLPLSKILGACMLLIVGIVFLRLEVKPQIESDARGHTYGASALRAEFAKNLLLGFTMSGFNPALLATYTGALASVYHTGYLEFTLFLALFFGVGTACGISTWFYILLSLLKTYKQRLKNQTIGAILRGMGMLLITLGLYCTKSAFDYFFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X5D4</accession>
    <name>A0A6G0X5D4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_008310</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000101">
        <property type="protein sequence ID" value="KAF0735097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X5D4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017024"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15565">
        <property type="entry name" value="PHD2_NSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055198">
        <property type="entry name" value="NSD_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46235">
        <property type="entry name" value="PHD FINGER-CONTAINING PROTEIN DDB_G0268158"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46235:SF3">
        <property type="entry name" value="PHD FINGER-CONTAINING PROTEIN DDB_G0268158"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22908">
        <property type="entry name" value="PHD_NSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="114"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0735097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="434" mass="48047" checksum="CECD9CE34C8CA9FA" modified="2020-08-12" version="1">MQVACPWCWKEFPQAGDSLAVHLSTCSLGGDPDGTPDYKSCSICLKLFGLNTPANEILFHKEECERINGAPPKRPGPQKRRRGSDTDKHSSYVRVTAPSVMPQESLPQAPETTSTECFSCGMAGRQLLVCTGTCSRSFHVGCVSEPATLIQRQALSARKQWKCAECSRSIHTCFVCGFLGDDGVDLFPCAYNGCGLYCHDRCAKVDHMATFICPRHTCNRCNQPMVATAEAIFCYRCSKLFANPVGHFGDCGGHQSETPPSHLKSKLAVGDIVLVLEFNNKVLSVRARSFNGNQWGRITKVESIAEWGPQLLDVELFACGNIISLGSNYVLHVRSNYSPTMECLKECMISHFHAELSVRDPTGTGLTMTHRTDAAMDTCLTFQNWGRQLKMTSSQMIDITHHGFLTWTKERAPFDFLDTRRRANSFKSKSKASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X5R3</accession>
    <name>A0A6G0X5R3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_008411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000101">
        <property type="protein sequence ID" value="KAF0735202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X5R3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012183"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0735202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="353" mass="39419" checksum="4983F24E180773F0" modified="2020-08-12" version="1">MPKVSYRPIVQPTFGLISERSHAHRDSTAMTVVKSESLSPHRRLQTNLGQRFVCMLATMEHIARLNVDDEHGSHHNDSHHENNKTDSTPPAVAVAALPRPQDEIDPHLKPRRMSVPTTEHLASSRPPPRRSMPSIVPPATAIPTTTKKKRKKRRKKRIKRTWKTSHATWTRHATTSECQTLERPSSLRKLNILHKLNDLKPVASVVAARRNIATISTSPDLVLGGADDDLSEPSSESEDSVGDQDAPMEPSKIGALEESPARKITIDMRLTVDPPRPPSPPRQRDQGVHGLKTPADDKPTKPCKLNHAATFITPEMTLWLKKCGMFKVKPKRDVVLTMDDQVKQIKRPAALTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X6V1</accession>
    <name>A0A6G0X6V1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_007713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000093">
        <property type="protein sequence ID" value="KAF0735701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X6V1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007175"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33324">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33324:SF2">
        <property type="entry name" value="MYB_SANT-LIKE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0735701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="248" mass="28194" checksum="3489F67344597B5E" modified="2020-08-12" version="1">MATTSSTSPKEPQWHRDVCTCEDCKAINLNGRSSIEVLLAWLTYEDPMTGRFSKLVVCTECAEVLKQHGFNREAGAVKNKLIELTQKSSSYCDFMSSTGEGVMNELNERFRDDTENPHYLDQVSALEKRKLKICRYYQELTCWIDLPQCQLFTHSQTQEEPDDDGSVEEPSYNPGTPTKEHHSYNPGTPPKPVMPLVQKSQSIVDLRNATSGASRPADNQHVRMNKRIKLLGEETKENPRLPMPLQME</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X867</accession>
    <name>A0A6G0X867_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_007222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X867"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002442"/>
    <dbReference type="OrthoDB" id="70263at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0736199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="87" mass="9784" checksum="720E650C0A325B57" modified="2020-08-12" version="1">MEFLGDNLDVDREQTFMEKHGTAIAIGALFLGFLHFSWLLYSSIKPIWDEMKATEAEQAALQAKMAASGKKKPLIVAKDRVKSKKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X8U4</accession>
    <name>A0A6G0X8U4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Disease resistance R13L4/SHOC-2-like LRR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_007373</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X8U4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019696"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF54">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="5">
        <location>
            <begin position="109"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="334"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="589"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="622"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="591"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0736353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="672" mass="73937" checksum="9101359D97C110F6" modified="2020-08-12" version="1">MQRTLRQSRHTGSLNLSARELKDVPDAVYFPRRHKEVDEKPSDWKDLVKLDLSYNDIVTLSPDIEQLKALTWLKLKQNQILDLPSQLGALRKLVFLDVSNNQLLRAPQCLSQLQELRELSLSGNSIKSLPDDIGLLVKLESLTVDQNQLCEIPASVGSLALLRTFTAQENSLEALPESFQSLELLETIDVSKNKLSTMPSLEAMSRLKSVDLRHNQLTDLPSLPSTTPSTLAQVFAGHNRLSAIASDQIARVGASLTLLDLRFNQLELLPSSVSTLVRLKTLDVSNNNLIDLPSGVGSLESLNHLAVDGNPLQSIRQSVLAGGTAALKQYLISKNPQVTDEPNPTEAKTSSSSDTLPDHLVRDACASGVLDISNRRSLDFSSWTIPRFNTTLVHLNVSKNGLTALPSGLGAFTSLQTLKAEDNHLTELPADLASLPRLQALRLQRNHLTNSGIASELDLRHNELTEVPQGLDSFASLDTLLLSYNKLNSLGNHVEWRHMTKLTTVHLSHNQLESLGSIYLAPCLTALNAENNNLQEIPLEFGHSPHLCLLNIAGNPQRGIRYSFVQKGSRAVLQYLREQVSPPLAAVKRPILGDHTDSNRSVRRKPAMETQEAHEQPPPAESDDALLTLAQLNEKIKAAEGQLDGYSLSTAKQALLKKDLARWRAARARLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XBI2</accession>
    <name>A0A6G0XBI2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Endo-1,3-beta-glucanase btgC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Laminarinase btgC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">Ae201684_006590</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation. Active on laminarin and lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XBI2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011190"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01100">
        <property type="entry name" value="APPLE_Factor_XI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000177">
        <property type="entry name" value="Apple"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF17">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE BTGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14295">
        <property type="entry name" value="PAN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026266602" description="glucan endo-1,3-beta-D-glucosidase" evidence="16">
        <location>
            <begin position="18"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="17">
        <location>
            <begin position="340"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="18">
        <location>
            <begin position="432"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00043078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF14295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF0737428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="491" mass="52701" checksum="739F81E92C86CB46" modified="2020-08-12" version="1">MLRTTVWLSTWLLVASAATSLLGIGYHAADPGQIEDDFRAIAQHFGGVRTFLTHVGPVNTIDVAAKVGIKIAVGVPLEPKQLFDSNVEAAIDGAKSHPDTLDAVYVGNEELLGGMPEAQLVHAIRQAKQRLVDAGLTNVSVGTVQTDGSFLEHPQVADACDVMGVNIHPFFSEGPPAANFRARWQVIKSKFSSKARLTETGWPSAGGRSPTGQTADLAVATAFFKDFQAWHDQEKTELPYWFMFQDVPSKGGYETYFGLSTVDGKWKVNLTAASHGPSAVAPLDNAAQALAAGHQLRNDSSPTVSVTFTTLDGLGLTVQGNNIVAAQGMPANFSWRQATSSIETADGGCWTVSEQALDVEIVDCDKDDPQQKWIVEPRVNHVKHVTTQQCVEVSSTPEHHARLTPCDETNREQQLRVGGYEDTPCTTVEKNVDYAGNDIGHAEAETIGGCCNLCLHMPTCRAFSLAQGMCWLKSSVGVKTDKQGVDSAALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XBQ6</accession>
    <name>A0A6G0XBQ6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fungal lipase-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_006606</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XBQ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015754"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051218">
        <property type="entry name" value="Sec_MonoDiacylglyc_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856:SF24">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026271408" description="Fungal lipase-type domain-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="440"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="496"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="528"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="569"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="607"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="648"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="687"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="4">
        <location>
            <begin position="857"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="733"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="733"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0737444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1099" mass="123085" checksum="CB63398BB13D2C70" modified="2020-08-12" version="1">MRRWIVATVALSFAAAASQTGAWEATTCGGNLLSKSSEYGCALGRCKCWPVISTCDSSPGCDGDDLTSLAICQGQCKPTTLGILLNIVRWLFILGCPLAVFCYQVLKIRPATKTNSNESPSTDVDGQNGIEQVFRREQLLDVLLNQVNKQRQMMGNVVWHITHPLASEETIAVRRQRRRRRNSYHYQPDASYVQASTPVVSHDQGGDLAFPPDESEPRNQLDEYIDLTKVNSGRARGAYTIKMNPQTYLETMHENVVPSLWLCIIVLLVAILVFEFHPLQLTSKAVLVNPSSCISESGHPCEHLNWTNITLRQYRIEFEQSQLPSGAELLALELQLVDHSKPLDKVHDMGLYHLSLSTPKASHPVVQNYTNKLAFTCNKSTCSTISLAAVSLQRYDAALFDLRQRSFVIELEFTPPSVSRFDDAFPAFQLHVTFYVNTKAWLGIAIRCFLGLISTLFLVHFVWSLHKFALQRYAETIDTKSVYFHVWGHMSLERHLMVLMLFVLAVNDCPLMLFLNLPFVGAARQSYIIFRTVWETLSYVIILTSLMVIMDSYRKDCRQFSDGASLRIIGLWSILAKVGLAACVVLLRLGLLLFFRRSKDEMTHHDQWMPIVDILLVVAGISIFLYVAGVVHHVLEAQPYTQTRYLSLSFRYVTMVAFAILALLLLESVTTSAYPQVSTTKPTEYKATPLILDVSVAVLVSFLVLAYYPPSKLEPGLIPRGYVIREKRQYAVTPQENNSGAPSAFNTENTSPPSERPAGGRLQRMGAFRAKSISRPHHLLCLETASLLLNCSRYAYYRSSLFLSEDTGDDGVVKNPAAAYVNQFALMRDGLEEVLQVIDEQTDTNCLILHADFRIIFAFRGTVSKANVKTDLDVALDPIPWLPDELDTTQAPFAHRGFLRAYGAVRERCHAALDSLLARYGKQGLASDLVHVYCTGHSLGGALATLAALDFKLNMKLLVVLYNYGSPRVGSHGFSRLFNANISLAFRLVNEGDIICGLPQRVSTNCFGQGKKLYKHIGTEVVMDGKINGDFIIRPTFAEKNLIVEVRKRPGRHYLKGYKENLQVILDVALRNEKPVGDYHLPTALDEALYHDSMDDEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XC63</accession>
    <name>A0A6G0XC63_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_006252</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000081">
        <property type="protein sequence ID" value="KAF0737758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XC63"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019749"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0737758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="180" mass="20909" checksum="62EF99CBADA81651" modified="2020-08-12" version="1">MQDAHHQSEALCMYKSGKCGEKRAWKNGKQLKLCEAHRIEQNAIKMRSDKSLSLRRKMIREEKKKLDRLRRAEERKKMYWDASSSSSSSDEQMQWNGPFVDISDEIVTATCLETLERLGTQVLMPLYEEHPELSQAQKVTMLKFALMEMHKKMMHQIQSMEQAGCLFHRDASGSSPSRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XCM8</accession>
    <name>A0A6G0XCM8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_006278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000081">
        <property type="protein sequence ID" value="KAF0737785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XCM8"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0737785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="173" mass="19564" checksum="ED03D17B2E4B5275" modified="2020-08-12" version="1">MLAMDDKAACQSLTRRTNLQLVSLSLGSMLLAAVSVQLAARTFVKRFVRLHRKDWGRQFLGTSKQAVMVALSHRRRLGQFQNPPHDDACQSFHHLDQVVHDSVENEEPKIASRISSSRQRKESDDWLGMVLVLFSSSEDSTVPHRPYISAPSKTEPSRSFTKSTDTIQLYLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XE09</accession>
    <name>A0A6G0XE09_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ketoreductase (KR) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_005766</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000075">
        <property type="protein sequence ID" value="KAF0738414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XE09"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005014"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43963">
        <property type="entry name" value="CARBONYL REDUCTASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43963:SF6">
        <property type="entry name" value="CHAIN DEHYDROGENASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G15350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0738414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="24129" checksum="B076552941091629" modified="2020-08-12" version="1">MAPLVYLVTGANKGIGYEIVRILSERLGDEGVILLGTRSLENGQAALVKMKQTNPLFSYENVQLLPLDVVNSNSIQAAAELVKTTFGSLYALINNAGISGDSEGADACFNVNVFGVQEVLATFLLIMVPNQSINVVVASVVGAWTSAAMSPEHQAIFADYTSLHMPALRALAYDWKASQDGKKPCSRGLEWTRHLVCMVYPRPWYWAWPANLPTNIPTSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XE12</accession>
    <name>A0A6G0XE12_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_005702</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000074">
        <property type="protein sequence ID" value="KAF0738472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XE12"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006278"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF37">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="270"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0738472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="447" mass="50053" checksum="54A34D9E4B8B8459" modified="2020-08-12" version="1">MVRTSSLRYQAWKAEAWEGSYPDDYRTRLDEAAAELADDGSWKGSRPPSPRHLLTADGELRETCEVDDDRSEGDRRPFADQTAVDPGVPPSPMEAAKPKIPAVFCYHACHFRDTLPPPSILLMDTVPDNLDQRRMAKEVVLREGIDLSTEELEQQLAIIPEVPREVEPFDPDQLGVGEDELNDDEKEKMRVVLRKYRKFFIKSGNGLPPPAKGAVCDIDVGEAKPLAERARRIRPELLKKLFDLLRGLLDFGLITFSNSPWASPIVLVLKKGGKDIRLCIDYRGINELQELMRSPMPTLDGMLANFHAMQWFLSLDNASGFWVVRAIKRARKVSAFICALGHFEWTRMAQGLKNAPMIYQRMITNALFGFVDMPPGVADEDADGEPVDMFALGFKCDLSQLPPPANRTSFADDISDGADSWEGIVELTDRILARLTYFGVSISALKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XFB7</accession>
    <name>A0A6G0XFB7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_005393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000070">
        <property type="protein sequence ID" value="KAF0738781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XFB7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017546"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38899">
        <property type="entry name" value="DOMAIN OOKINETE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38899:SF1">
        <property type="entry name" value="PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0738781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="226" mass="25256" checksum="16EDFE96D7BE859A" modified="2020-08-12" version="1">MSALTKSPTLPPRVGSTKPISRPSVPSTPRHKPQHSQRPVVFSWNYFLCPVAWIQRHWKDITNEDRKTLARLDRSIVSVLLHARTLGPVYVLCEGGAAFVETLCRSLFPECAMLFSSIAMQEQIKLVCAATPISPTWHGHMLQFVVCQRASQLGVNLTVFGQTSLRNGCAALRRSHSEHTLRRIKMIQTSVAHPTVNEVLNRLEVVQENLALIVAFDDNIDSVLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XFG7</accession>
    <name>A0A6G0XFG7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-reducing end alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="4">3.2.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_005205</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 62 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="4"/>
    <dbReference type="EMBL" id="VJMJ01000067">
        <property type="protein sequence ID" value="KAF0739017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XFG7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013389"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005193">
        <property type="entry name" value="GH62_arabinosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40631">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE AXHA-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40631:SF1">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE AXHA-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03664">
        <property type="entry name" value="Glyco_hydro_62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0858">Xylan degradation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0739017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="330" mass="36156" checksum="849EA12CAE5EDF07" modified="2020-08-12" version="1">MLVGEANASADSFATSNTTASTAAFCDLPKTLKWTSTRPLAQPQHGWTSLKDFTNVVYNGKHLVYGSVYTGTKYVSTGISPFTNWSDMATATQNIMPFSAPAPTLFFFSPKNIWVLAYQWGSARFTYRTSTDPSNVNAWSAEKPLFTGANPVGSPSGFLDQTIIADDKNVHMFFAADNGHIYKTSMPIGNFPGNFGSSYTTVLSDSRANIDEAVQVYKLKGQNKYLMIIEAMGSRGDYFRSFTAPTLDGPWTVQAGTESNPFAGKANSGATWTNWISHGDLVRTNPDETFTIDPCNLQFLYQGFNPSSKAPYDALHFLPAVLTLQNPVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XGJ4</accession>
    <name>A0A6G0XGJ4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_004990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000064">
        <property type="protein sequence ID" value="KAF0739424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XGJ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016867"/>
    <dbReference type="OrthoDB" id="158896at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0739424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="92" mass="10062" checksum="66874A329F22CC1E" modified="2020-08-12" version="1">MSSSVTYEPASNNLTEDDCVRLYKIYSSSDKLPSACKDLLQRKKSGTTGYYGVAENHSLNVKGGHRGKRGDGESHASLQRRFTGPMSGYGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XGS1</accession>
    <name>A0A6G0XGS1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_004983</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000064">
        <property type="protein sequence ID" value="KAF0739415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XGS1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016860"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045107">
        <property type="entry name" value="SAC3/GANP/THP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005062">
        <property type="entry name" value="SAC3/GANP/THP3_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436">
        <property type="entry name" value="80 KDA MCM3-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436:SF4">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03399">
        <property type="entry name" value="SAC3_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="2">
        <location>
            <begin position="446"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0739415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="627" mass="69560" checksum="EBCBBF5A7C00C774" modified="2020-08-12" version="1">MNPQQSNPGVVQYAGYSQFYASSAPARPPFRPPLVQGQQQYAFQNPHQAYQYVPPPRPPLQVPGPRGTVAAPPRPIPAAVSSGSRWDKIPPSSNPVATSVQKNQWHWNTGKTMPTPTAPSTSKYAPPVTVASAPPRPYTPTTSKFHAQPFPPSKFQDQPTPVSTSSTSSTPAAGQWPSSLKSYVERAFANCRSDADKSIVQSILKEKISAAMTANNLWTKNWDAESLPLNASTSAVAATQPPPRPMINVRPPPPPAAMTPFPRPPMMPMPQQMPKPHSMPESFIPLDSKKGAKKKASKRKADSDDGFDDDLDGLNKKMQRQQRFLKDSFIANTIRTPSYTGPLQVLNDEGELDLEAMIIKGTCTKIEKDYLRLTSAPHPSAVRPEPILKKALDMVRNKWKEGKCDYLYVVSQMKSIRQDCTVQHIKNDFTVLVYETHARIALEEGDMNEFNQCQTQLRQLYESGIAGNRTEFLAYRILYCIYVCLQGKTDNSGNVGMYRALSMVTSEDRKDSTVRHALAVREAVFANDYQSFFKLYAEPPKMSGYLMDAYVNHMRLQALKIMCKAYQPSIPIDFIKTLLLLEGKEGQAFIKECGIQFVGGNKGPREAVDCKASDIVSVLKSNAKSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XH62</accession>
    <name>A0A6G0XH62_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WKF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_005025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000064">
        <property type="protein sequence ID" value="KAF0739459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XH62"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014369"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019327">
        <property type="entry name" value="WKF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22306">
        <property type="entry name" value="CHROMOSOME 7 OPEN READING FRAME 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22306:SF2">
        <property type="entry name" value="CHROMOSOME 7 OPEN READING FRAME 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10180">
        <property type="entry name" value="WKF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WKF" evidence="2">
        <location>
            <begin position="59"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0739459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="170" mass="19630" checksum="192C285F26785E4E" modified="2020-08-12" version="1">MGGKRRRNTGEAAKKRYKSEKEAEAGKKEEKEDEKPVTGNSNDMENKPSPELIQEAKYYLESWQTHVKGSSAASSETPDAPTWRFKKAKQVWILRWMYRADVVNKALFAIVLEYLGGMQGTARERVLRDAQQIVEALDEMEKIDEKDQTLQQKLERRKLKRAFQIAKVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XHG7</accession>
    <name>A0A6G0XHG7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S ribosomal protein L23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_004649</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000062">
        <property type="protein sequence ID" value="KAF0739757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XHG7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000683"/>
    <dbReference type="OrthoDB" id="407959at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00337">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.150.20:FF:000003">
        <property type="entry name" value="60S ribosomal protein L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_uL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_uL14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_uL14_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006344">
        <property type="entry name" value="PRK08571.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L14/L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0739757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="14709" checksum="01DCB510F67B18F0" modified="2020-08-12" version="1">MAAAGRASVSGQKFRMTLGLPVAAVLNCADNSGGKALMIIAVCGIKGRLNRLPAAGVGDMCLCSVKKGKPELRKKVMPAVVIRQRKAWKRRDGVFLYFEDNAGVIVNPKGEMKGSAITGPVGKECADLWPRIAANAGSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XHP3</accession>
    <name>A0A6G0XHP3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_004668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000062">
        <property type="protein sequence ID" value="KAF0739782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XHP3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009672"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026219930" evidence="1">
        <location>
            <begin position="20"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0739782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="177" mass="18924" checksum="69216958C8904991" modified="2020-08-12" version="1">MVSSAILLAAALAVTAVHAKISPQLTRAIEAGSTPYVVIVEFNSIDAALEKANVRLESVQTRAEKIHTILDSLKAHAKNEQAAAIDIITNSQSAKELNDGFSYESYAISNIIALNKPSPALLEKLTTVPSVKAIRHQYMGRIPKITEIAQVEDVSPPTTNLNGALPRSLPLLFGAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XHV8</accession>
    <name>A0A6G0XHV8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TCTP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_004622</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TCTP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000061">
        <property type="protein sequence ID" value="KAF0739814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XHV8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010295"/>
    <dbReference type="OrthoDB" id="10248936at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.10">
        <property type="entry name" value="Metal Binding Protein, Guanine Nucleotide Exchange Factor, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011323">
        <property type="entry name" value="Mss4/transl-control_tumour"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034737">
        <property type="entry name" value="TCTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018105">
        <property type="entry name" value="Translational_control_tumour_p"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991">
        <property type="entry name" value="TRANSLATIONALLY CONTROLLED TUMOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991:SF0">
        <property type="entry name" value="TRANSLATIONALLY-CONTROLLED TUMOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00838">
        <property type="entry name" value="TCTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51797">
        <property type="entry name" value="TCTP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TCTP" evidence="2">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0739814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="180" mass="20091" checksum="424795189FA46975" modified="2020-08-12" version="1">MLVWMDIFTDDEVVSDSHNVIDAKDKEGNPIPGMLEVGSKTVTKGGLNIDVGCGDAFGGGDEEVDDSVETVNNIIDESVGFGYTETGFNSKADLKTYLKSYFRKIMKHLKSTNASDEKLEAFKSDAQEIVKALVALYDDLQYYMFRSMDTEAGMAFSYYKDGDTTPTFLYIKWGLKEVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XIU0</accession>
    <name>A0A6G0XIU0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">General transcription factor TFIIB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_004276</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFIIB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000053">
        <property type="protein sequence ID" value="KAF0740275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XIU0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003907"/>
    <dbReference type="OrthoDB" id="25790at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF13">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="Zn_Ribbon_TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="7">
        <location>
            <begin position="9"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0740275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="310" mass="34123" checksum="B9CEB5F3E8D76477" modified="2020-08-12" version="1">MNYRQSYPSPMESSCFECGSDDIVEDYAAGDLICRGCGIVLVERLIDESAEWHNYVEDDRARGDQSRIGEALDTRMGETTLQTYLVKRAGQSDSEIAPKHLNGAQSTEVLRRHEGVEQIKNLAHALNVGQTVVECAISIYARVEDQNLFPHRRSHEKNGVFAAILFMACRDCSHSRTLKELEVVSGVDIKRIGKSLGVLSRSNVASKKQVGTEDFLSRFCSSLDLPSKTPILALRVVEKADKMGLVDGKPPAVVAAAVIYMVAAYTNSKRSLEEVSQASLVGEKMVKDVCKVLNQNKSLFEDLASPKVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XIX2</accession>
    <name>A0A6G0XIX2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST2</fullName>
            <shortName evidence="8">Oligosaccharyl transferase subunit OST2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_004304</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Endoplasmic reticulum membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the DAD/OST2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000053">
        <property type="protein sequence ID" value="KAF0740305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XIX2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018025"/>
    <dbReference type="OrthoDB" id="445566at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003038">
        <property type="entry name" value="DAD/Ost2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10705">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10705:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02109">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005588">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0740305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="128" mass="14162" checksum="0C02C3B6BDC260E4" modified="2020-08-12" version="1">MSKKGQKKESAAAEPPSTQSIVADLWTQYSKNTPRKVKLIDGFLVYVLATGILQFVYCVLVGTFPFNSFLSGFLSTVGVFVLTVSLRMQIDPSNQQAFAASPRSPQRAFADYLFCNCILFLVVMNFMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJF4</accession>
    <name>A0A6G0XJF4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_004093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000052">
        <property type="protein sequence ID" value="KAF0740354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJF4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012268"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0740354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="167" mass="18205" checksum="C0AC2B83C60ED5FA" modified="2020-08-12" version="1">MDSILKLSLQAMAFLTQRRSVIARCVVALLSLVAFIRSTRMTGFVGGDFFFVSSFFIVGYSTLQAYSKSYHKILLLPKTAEIVVDVLAALSLLICTVAFTVFVNWFGRVGLAIYATACIFQIFVVACHCASPAPTSNPDDQSRDFTIANSPTAIKDAFKAQQVKTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJH1</accession>
    <name>A0A6G0XJH1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_004182</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000052">
        <property type="protein sequence ID" value="KAF0740447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJH1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005294"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115:SF0">
        <property type="entry name" value="FI21273P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115">
        <property type="entry name" value="KINESIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3 4" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="7">
        <location>
            <begin position="10"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="261"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="118"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0740447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="465" mass="52235" checksum="554006368CEBCB45" modified="2020-08-12" version="1">MTRPSKAKKQVDVHLRIRPLVKEELERQDTKMDMSIVPSDDGSTSLKLTTPKTDADDVEYVEVLGFQVPKSKPKRDKTFRRFASVHHDVTNVEFFERTVAPLVEDALAGRTACCFAYGHTGSGKTHTILGYGSELGMYRLASTRLFEAIDELSDQHQTVDRLDQPKLQVRFNEIYNGEVYDLLNDGAKCFVREDAHGKVHIRGETRVDDETGIVSTTFSQSPIASTLDELIEIVQRGIAARATGNSDVHRASSRSHAILEVEFVSDRILRLREAVDDLEQEYTAIRHERDTLEMDIFTRQHYKVEGKWVKKENAQGSTEEECSRLLNLRKQYLLVESQKRAAQRNVDDAKQAGLSCLGGTLVFVDLAGSEHAGKESDGIQKTDEEQQECREINKSLSALKACFRAQAVGQTSTSCYRNSKLTLVLRDHLRSHASHTAMIAAISPSNFHATKTIHTLQYAQLVAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJM6</accession>
    <name>A0A6G0XJM6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CDC20/Fizzy WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_004049</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000051">
        <property type="protein sequence ID" value="KAF0740502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJM6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003431"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF8">
        <property type="entry name" value="FI02843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="9">
        <location>
            <begin position="105"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="150"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="234"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="365"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="69"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0740502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="421" mass="46429" checksum="61E26DE55A3C69C9" modified="2020-08-12" version="1">MASVQRRCHTTTDRFIPSRAAMNVDLCQYMLSSSSSSYVPDSSFKMPSHRDLLFNTLVAHADDDSRLLRFRPRDRQPHPSMAPPPSTGRTTNRWKRRHVSPTRVLEAPDLRDDYYLNLLAWGPTLLAVALDKLVYLYNVDTGSVSALNTLTSGEEYVTSVTWLSDRSLAVGTSDAQIQIWDVATSTKVRMLQPHEDRIGALAWNAGQGVLSSGSKDAKIMLHDMKTPQGQVATLRGHSQEVCGLAWSPDGKTLASGGNDNRLSLWDGPMSHAPRTTLMQHSAAVKALAWCPWERHLLASGGGTADRCIKIWQSHSGVLQQSVQTGSQVCGLVWSPKGKELLSSHGFSQNQLCLWSYPRMTRLREFTGHSARVLHISLSPDGRSVVSAAADETLRFWNVFSSAKSPVQPRLGTQLTTLGSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJN7</accession>
    <name>A0A6G0XJN7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_004210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000052">
        <property type="protein sequence ID" value="KAF0740476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJN7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010448"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0740476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="235" mass="24107" checksum="E5B9AC314F3512F6" modified="2020-08-12" version="1">MPHKTSHYPPQETTAHSPTATTPQLTTLNPQQSDTATTATTVLPPLTTTSSTGSQGPAPTPAASVPLDYPSSSSSTLPAPGGTELSTTQTPGPSTASETNPSATQAKANYTTSFAPEATESSSTSRESQLPRFPHAPLTEEPLGPSPPQKSKPPLPPSPSLPSQPPSPPENISPSTSTTSKLSSGAIAGIAVGAVACAGLIGYLAWQKKKKVDDAYNNLLMHDHMTGSGHYMAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJY1</accession>
    <name>A0A6G0XJY1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">6,7-dimethyl-8-ribityllumazine synthase</fullName>
            <shortName evidence="7">DMRL synthase</shortName>
            <ecNumber evidence="3 7">2.5.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_004073</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:26152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="2.5.1.78"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DMRL synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.78" evidence="3 7"/>
    <dbReference type="EMBL" id="VJMJ01000051">
        <property type="protein sequence ID" value="KAF0740528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJY1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013610"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000906">
        <property type="term" value="F:6,7-dimethyl-8-ribityllumazine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09209">
        <property type="entry name" value="Lumazine_synthase-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="entry name" value="Lumazine/riboflavin synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00178">
        <property type="entry name" value="Lumazine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034964">
        <property type="entry name" value="LS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00114">
        <property type="entry name" value="lumazine-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058:SF0">
        <property type="entry name" value="6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058">
        <property type="entry name" value="6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE DMRL SYNTHASE LUMAZINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="Lumazine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0740528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="206" mass="22537" checksum="CE645A8E24799A75" modified="2020-08-12" version="1">MHAEGVKKVALEALSSRKLDGRGLRIGICTTEWNKEIIDSLREGAVRTLTEAGVAVDDIVLYKVPGAYELPYSASRLIQSENVDAVICIGCLIKGDTMHFEYICEAVTQGIMKLNLETGVPVLFGVLTVLNETQARIRAGLEEGGHNHGVEWAQTAIEMAHLRARTATKVAKKCPYHVLPACPFMWTTALAVLGYGVHLLVCRKHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XKC3</accession>
    <name>A0A6G0XKC3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_003971</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000048">
        <property type="protein sequence ID" value="KAF0740594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XKC3"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0740594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="97" mass="10738" checksum="EA4D7ACB37B15530" modified="2020-08-12" version="1">MLPRAVYLDASACLEKLNKVHVSKLSMENAGHVQLLVLLKFFELRVDGVIRSQAASVAVEGLPKTTLLNPCTIYNWVRQFESTGVLPKSCQGHNQNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XKV2</accession>
    <name>A0A6G0XKV2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_003571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000041">
        <property type="protein sequence ID" value="KAF0740999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XKV2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000832"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0740999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="159" mass="18144" checksum="CDAC1E2F4F30FB8C" modified="2020-08-12" version="1">MSACVPTIAAHQKLNLIEFPYVLALDLDEVPTVEHIFNHCRASKEDMLDRVKVVASALDYMHNKGLVHSDLRLCNVYLDDKILIGNLEASTKIGDYFPHGQFTTGVPPPELFYKLQNDEERQLYEDCWGQHPGWSTRFKPAHDIVVKAWAKSMPLHTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XL05</accession>
    <name>A0A6G0XL05_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">T-complex protein 1 subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_003818</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000042">
        <property type="protein sequence ID" value="KAF0740932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XL05"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011567"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03337">
        <property type="entry name" value="TCP1_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000085">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000005">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012719">
        <property type="entry name" value="Chap_CCT_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02344">
        <property type="entry name" value="chap_CCT_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0740932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="529" mass="58397" checksum="182A67BABE69666D" modified="2020-08-12" version="1">MMQAPVMVLNTNTQRETGRTAQLGNIQAAKAVSEIVRTTLGPRSMLKMLLDPMGGIVMTSDGNAILREVDVSHPAAKSMIELSRAQDEEVGDGTTTVIILAGEMLVVAEPFLSRQVHPTVIIRGYHQALQMCLDTAKRMAKQIDIHDKASMRNLIMSSVGTKYSPRVGNIVSDLALEAVLTVMRTNPVTGKKEVDVKRYAKVEKIPGGELEESRVLSGVMFNKDVTHSKMRRRIENPRVLLLDCPLEYKKGESQTNVELTNEQDWNTLLRLEEEYIENLCAQIVAMKPDVVITEKGVSDLAQHYFVKANITCFRRLRKTDNNRVARATGATVVSRADEIQDSDIGTKCGLFEVRKIADEYFAFFEECQDPGACTILLRGGSKDVLNEIERNLQDALQVARNVVFEPLLLPGGGATEMRLAHELRQRAHEVEGVEQWPFKAVADALEVIPRTLLQNCGADVVRVMTALRAQVAASNGGFAVDGVKGVVVSSDELGVWEPYQVKTQTIKTAVEAACMLLRIDDIVSGLKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XL20</accession>
    <name>A0A6G0XL20_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EFHB C-terminal EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_003626</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000041">
        <property type="protein sequence ID" value="KAF0741054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XL20"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005652"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057428">
        <property type="entry name" value="EFHB_EF-hand_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25325">
        <property type="entry name" value="EF-hand_EFHB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EFHB C-terminal EF-hand" evidence="2">
        <location>
            <begin position="328"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0741054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="420" mass="46135" checksum="0D80AF534CD87DEB" modified="2020-08-12" version="1">MSRQTPPPKAGTKQTPSTHESSAACLSFPGRPGTPEAVRKYRKSYFAEPGTRIVHPGLIDDVKQLDANRKFGVTSKNSDHVTDVLPSKFPSEHALLTQAKLEAVYLSSKREPLGVPFTRGHNVDHSATFGVPSGLHNSDMAKELLYHSEFNETPDSKALYKRSHGSSDPGEQKNRQYDVPFDLHKARHGAAKKKEDSGGVSAVLNPEMDEQVSKLFITQKNVEDMKNTMDMLGRPRNLGCGHLPDPDHVFGVKLSKDGPDAATCIHGSYSFEEQQPDPDLGKPVNRGWMNATADQRAFGVPSIRSDVAPPSKRSIADAQNYGDDVNAHELLYPNQYSALGVSDSEFAIPRSKSFLCDLFSKIGYPLPADIAEQIYRRATMRTQHTPTGVASIHDFQEALNDYLDAKDSGPAALSQWKAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XM09</accession>
    <name>A0A6G0XM09_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_003522</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000037">
        <property type="protein sequence ID" value="KAF0741417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XM09"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015734"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
        <property type="entry name" value="FYVE_like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="280"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="377"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="397"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0741417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="460" mass="52237" checksum="17223A78695F815A" modified="2020-08-12" version="1">MPWRDLNKGSFNCAPLTEEARDMLINEAKIACKYLIVNATTATDTTPVDKVAVNEKTGRHATFRKIKDTVDPKLEGVHAYTRVRATIEDVADFFHLNTPIKLENYDRVMRDWVVKLTTLYTLIERSDRGSTTKPLYSCGVIWKVTKVTGTQPRDLCLLDYHDEFTYVDQNTGEARRGWARCIHSIKLSCCPDLNPRYGLLRTTVVRSGHVFIESSEPGELDYYKVHITVPPRGSVNQFTQLIYRTMLKFYSSTVLHFEEHFIRERIKPMLDLPVSRFQHKLKTDYCAQCFTRFTWMTTCRQCRGCGDAVCQKCSSKWSILLDTHKHAIKVDMCRQCVTGETKRRRPAQPKSGAASIIMGTTPRSAYMHVDFYAQSEGSARSSSAPVEPTTDTIYESNSEKGERNTSPQDKSESRPQCGKAPVAGLEKFDLVVPWLEPTISPSDILQERLTFDSSAPVQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XM14</accession>
    <name>A0A6G0XM14_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_003510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000037">
        <property type="protein sequence ID" value="KAF0741405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XM14"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010898"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0741405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="240" mass="26998" checksum="440BDBE8BE901C45" modified="2020-08-12" version="1">MPRRRRLDNWRKIWINERGALVVLSIMSLVFIAIYSSASTPWLEHNWSPGPNEKRHRVEVYDPFFQGLLPDEEVNALPSVQWSITLWNYCVSTTVEGRGEPTESCYAWKDVCTTHKSDVCMQLATMQSLSFLSVLLSMMALYAAYRALGETSGLMPLWSMSCRVLQIAFETGLILLAYDLVNARPAFPEGMLISSGALVCATHMCVSLLGFIGAIFVFLRSEPEVEPTFILFSNELANPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XNY2</accession>
    <name>A0A6G0XNY2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_002917</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000032">
        <property type="protein sequence ID" value="KAF0741976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XNY2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017406"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="268"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="389"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0741976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="493" mass="50766" checksum="A1C74E9BD8B478CF" modified="2020-08-12" version="1">MMRPAAIDTPAAFTSGPAMTPTAAEKNPLEDDVLLEEKDKNNADVDGTLNAGDDVDLGSTKSSSKSDTELIGNISDNDPTKEDKREKYSGNRLVSYAFAVVGVMLFVGAAAFGLFYFKDDISKLLGQSTSSSSEAPSVAEINTTNTTNSSSVHELDVVNPHTATHTTAVPSLPVTTRSTTSAPTTAPSTPTVTPVSTAATTAPVTTTLRPLETTPQPTSTVTPGPTTTPLATTPQPTNATLQTKNETIQVVNTTQVPNSTTMQPTITAQATTTSPPTTSPELSTTAQPTTTAPPTTTVQTTTTAQPTTTAQPTTIATPEPTATPKPTTVTPEPTTTLETTTTSAPTTPVPETTVKAPLPTTEGMAPEPTMFRWKLSDTTPTPTPPLTSPPASSLTPKPTSDTPIMTPASTDDASASPETTALPTTKSPVGPFEDNSATAEPTTTLNPKVEIEFLSTPAPTTTKSVTSIIDSLMAPTTTAASTDSTPSSGSNHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XNY9</accession>
    <name>A0A6G0XNY9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Choline kinase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_002877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000030">
        <property type="protein sequence ID" value="KAF0742212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XNY9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005773"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004103">
        <property type="term" value="F:choline kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05157">
        <property type="entry name" value="ETNK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF93">
        <property type="entry name" value="RE24176P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0742212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="39159" checksum="FCD3B1475202B8BC" modified="2020-08-12" version="1">MARSSYVLNAAAYLHPSCTERDRVRFQSDVVAALGAHLPAWTAVSPANAVLTHVSGAMTNVIFTCEKRVAPQDKVLVRIYGHGTEAFFSRQEEIRVFQELSRQNLGVSLLGEFQNGRVESMIDGRTATASDIRIPEFSAKIAKKMALFHTTQVDMDRNPRILNNIHKLFKDAKTAYASGNRTSFDVDAMARDIQALEALLATVDSPVVFCHNDLQYGNIMATDTNDAVMIDFEYSHYNPRGYDLGNHFSEWCYDYHGAAPHMGDFCKYPTVAEQRHFCAAYLGDSATESTVEDLRHEANVYANATHLFWSLWGFIQATQSAIDFDYFGYAMCRWNAFKMQVSMQNRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XQZ5</accession>
    <name>A0A6G0XQZ5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_002050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000022">
        <property type="protein sequence ID" value="KAF0742986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XQZ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008395"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="2">
        <location>
            <begin position="176"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0742986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="221" mass="24876" checksum="E9A6BFBE33B2D73A" modified="2020-08-12" version="1">MHQIGVFQAISVKVTKATSIQSREHDRPVIMYTMEVDNKESQTSWSTTRSDSDFKSLHAAVCNALDHGHTCDALCPWFYVDFQQKLPKKSLFRSRTHKRSIQANLDTYHDLLSMLMAFIIASKNHSCYRANDRVSNVLFDFLFRDCSVVDAAVYTSAKQRSSTSSIRSSQSDDCECSLCNQGSNTCSSWTRLPCGHVFHDDCILEALNKSVACPECHGAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XRJ0</accession>
    <name>A0A6G0XRJ0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Hexose transporter 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Ae201684_002036</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-fructose(out) = D-fructose(in)</text>
            <dbReference type="Rhea" id="RHEA:60372"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:60373"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>D-galactose(in) = D-galactose(out)</text>
            <dbReference type="Rhea" id="RHEA:34915"/>
            <dbReference type="ChEBI" id="CHEBI:4139"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="7">
            <dbReference type="Rhea" id="RHEA:34917"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-glucosamine(out) = D-glucosamine(in)</text>
            <dbReference type="Rhea" id="RHEA:78423"/>
            <dbReference type="ChEBI" id="CHEBI:58723"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:78424"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-glucose(out) = D-glucose(in)</text>
            <dbReference type="Rhea" id="RHEA:60376"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:60377"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-mannose(out) = D-mannose(in)</text>
            <dbReference type="Rhea" id="RHEA:78391"/>
            <dbReference type="ChEBI" id="CHEBI:4208"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:78392"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-xylose(out) = D-xylose(in)</text>
            <dbReference type="Rhea" id="RHEA:78427"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:78428"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000022">
        <property type="protein sequence ID" value="KAF0742971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XRJ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013663"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="15">
        <location>
            <begin position="1"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF0742971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="399" mass="43947" checksum="9033C5883404EFC1" modified="2020-08-12" version="1">MDSVLKDFCEGYDNNSMTQCTAASADLPDNWLNFTTRYNVLYYIGCILGAYLGGVVADKFGRRTTIFTAGFLFCVGTCLLVFTNKGNHVLSLVARVIQGFGSAGLINYGVKDTTHGWRTTNAVAMAFPVIVMFGIYCVPESPRWVYQHKGREAAESTLARLRKTDNVGEELKAIGDELAEEGNGEATWKEVFHPTIRRRVFIAMALQLLQQATGINPIFTYGAQIFKDVLGDGIGVLLILQIINFLSTIPAMHWVDKTGRRSLLLLGGAGMVIGHLVSGISFSADCHAFFVFNFAISWGPVCWIYPAEIFPLKVRAKAVSLSTMTNWAMGALMIGIPKLFPYLHVNGVFFLFAVLCACAGIFVYYFCPETKNVLLENIEMLFNKNGRGAEDVKTPNDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XRM7</accession>
    <name>A0A6G0XRM7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase S10 serine carboxypeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_002011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000020">
        <property type="protein sequence ID" value="KAF0743221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XRM7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006050"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0743221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="149" mass="16375" checksum="C910141BD93920E2" modified="2020-08-12" version="1">MTIFLNNETVQQQLHVASDRAGTWRVVASDVNENLSQTMFVNADHYVATVLAHNVPVLMYAGDADLMCNWKGVEAWMVALPWPGRDAFNSAPGVPFIVEGTTAGELRTAGPLSFLRIFNSGHMVPTDQPVVALAMLNRFIHQTPLTSHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XSF9</accession>
    <name>A0A6G0XSF9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_001816</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000017">
        <property type="protein sequence ID" value="KAF0743339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XSF9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020287"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09279">
        <property type="entry name" value="RNase_HI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF37">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13456">
        <property type="entry name" value="RVT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNase H type-1" evidence="10">
        <location>
            <begin position="638"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0743339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="963" mass="109456" checksum="A4D559485C6470F9" modified="2020-08-12" version="1">MEKEGRRNGSVHDDSERKQFDQEALSSVPSEAEDMPLGGSLPHPQIFNLKSVPDVDQSQCDPELQILEGIDMSPEEMENQLALIPEITPCSEPVKIEDLDYGEADQSGEEKEKMRKVLAKYQKYFIQSGNGLPPAARGAVCDINVKGAKPIAQRARRVRPEHLKQLFELLKGLLDYGLITFSNSPWASPIVIVLKKGGSNIRLCIDYRAVNDLQELLLSPMPTLDCMLANFDAIQWFLSLDNASGFWVVRATKRARRISAFICPLGHFEWTRMAQGLKNAPMIYQRMISNALFGFVDLPPGVSEVDEEGEPRDMFRINYRYPEEKMPPIANRTSFADDISDGAETWDGIVELTDRILARLTHFNISISAAKSKFGKRRIEFLGRWIAQDGLSARPKGLAQLVNIPFPASLQGVQSFLGSLNFYSRFIENYSIKASSLYELSREEIEKGEVSEASRLSFEELKRDFAALPTLKHSVANQDVHVLLYTTRWAISATVCQEFDGILHPIRFCGRVLKGGEPRYEGWAKEVLALLRVLKTCFFEVRSRMLVVYTRFALLNWLLKDKQAKSENLHWAAMLAPWSIKVVQVQELDGRWNLPIMLTSTLRPPDSTTLESFELFEPNKTKDGLKPRQVRMPTITELNGAFLAAFDGSIKTSERFGAWGAIIWLLPEWKIVWASSGVLEDATVNLAEYQGAISALEAALQLGIRSIQVFGDSKLVIHQALDWMQCKQPHLQGKLKELRKLEKQLTRVDYHHVLRRWNASADHLATMGMQHRGKAPDLTVEDLNELQEKNLLAELLQDQEESQAKQVESISFNSTHDQTSAPETGKIWAFTHPKPNSTTVGLSLKIRLGRISRAQDREKRWSTLKNYLKGNFDELEAEDISKAIKEAGSFEIGEENALYRLNWSRRRSPEPQLVWSLVIPANLVPMVLQHAHDSLESGHLRFQNTYERLRRHFFWPRMYTDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XSW2</accession>
    <name>A0A6G0XSW2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_001775</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000014">
        <property type="protein sequence ID" value="KAF0743514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XSW2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012100"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050367">
        <property type="entry name" value="APC_superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42770">
        <property type="entry name" value="AMINO ACID TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42770:SF7">
        <property type="entry name" value="MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="360"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="427"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="6">
        <location>
            <begin position="45"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0743514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="516" mass="56736" checksum="FB64FC20E6B4BE99" modified="2020-08-12" version="1">MQVAPHTLDATKPTPVVQRARSSYDLWAIGITIVIGGQFFGWNGGVAAGSVGFGIAVVLVGLAYVCLACSMAEMTSMLPFAGGVYGLARCTLGFYAAFVLGCCELLEYVMYSASINVALGRSVISAVPSLESYAPLIWFISHIFTLVLLCIGGRFFWRCNFVMAVIMIVVVAIYCFGSLPYTSWSANAGTSDNNLFQGGFEQFFASFPMAMWFFVGVEALNTLSNEVDDPKNTIPRGQVAAAFTLFVSALLVYVVTLGLPPGVAGLPNVLVIFNSGFTQIFKINDTQATMFSLVAEFVEVPGFLFAASNIFVALSESRLFPHELCYRSHRFGTPIYASMGVTLLSFVLCFGVTYQPDIDVILYCMSMFFGTLTYTSQCVGYLFLKKRYRTMERTFKSPLGIYGPAFSIVVFVMCAISIVAFQPGSPTARFSIVSLLVLLSVYYHGYAKSRQTFSDEERKVLFFAHIAIHNNSKHKHRSNLRRLMDKLLSRVSAAMIPTEKTNAQASERSPNKRDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XTI2</accession>
    <name>A0A6G0XTI2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_001476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XTI2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002715"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0743830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="345" mass="38309" checksum="3B507B7DB7BCCE65" modified="2020-08-12" version="1">MEEHRRGSKSHIQPVTTLDADYDDAEYDTLHQDPRGDDILDDSEFFTTWMGKPSMMNDLCMFLAANQGVQTAVHVVSSLIGRWTCWKANWETETLRSFLEVLVWTSVTAVAYSIHRDALWAAQIGLTVGIAMSICDEVFVAGARSLLESIEQLPNGAALLRKWGFDVRSSVDKDAKTVTTTSSQDVQLIKNVVFGALALEAIRHVYLSSTQDVQHFSAVTTAMGVAFVVIGELFCLWLPTRQLGLTVQSRWTNISENWQNHFVRSLVEVTCWLLCLLYVYATTASIGNAVLWSSVLGVGFCIIGGLDPLDAKDSSVYVSSYWAQWAGHGWLDTAEMLLSIVPKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XU84</accession>
    <name>A0A6G0XU84_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HORMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_001643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0744006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XU84"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018901"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016035">
        <property type="term" value="C:zeta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045091">
        <property type="entry name" value="Mad2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842:SF10">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="1">
        <location>
            <begin position="4"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0744006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="212" mass="24026" checksum="BB5610907E1FF9C8" modified="2020-08-12" version="1">MAEDILATALLDFLEVATHEFLYHWRIYPQGLFDKWKKYDVPVHICRHPKLVEYIRSMLQSCRPWIVQGRVDKLSIAVRSTTTGALLDTCVFELRLTTFSGKEMPKLQVEEAFRRSLVQLSAAALSRDGRSMDDERTFRLFLHTLEDSDMHETLVSDDSIENSWILAPREELSVSQAGVVPVASISETALPIQLNMYLVSPHVVSASSTSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XVM7</accession>
    <name>A0A6G0XVM7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_001167</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XVM7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012872"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="79"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="128"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="408"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="550"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="593"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0744710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="685" mass="75755" checksum="9A612666E5F1C24B" modified="2020-08-12" version="1">MAASIQFLLQETFGVGGDHHVGIGLTNKQDNIHASHAISTISAYKCIPGVALFAGRQDGKLVVWNYANQTNLLAQGHLFGGHGGPVLAIEHTQRHDNTQLLFTGSADRTIKVWDPTRAYLDEQCIQTLNAHGGSITALKVAGTTLVSCSVDRTIKLWQPDKGRALLLHPWYVCTQTVSNGGSWPTSICVRATDLSSTYVADSTGTVSVYTTANNRERLDPTNEDQLKLKRLHNHFHTLGITKVMAIPDQNVIVTLSFDTKAQVFDATTGAVLLTLENPKHCRYTACDWDRTNHELHVVDDTGHLYIWSIETEKCVKVAPLGKGPIMDVTVFPGGHSVLLQRPDGAEMYHIQRDVSYVECHGHTDAVVAIVPVHSDPLALTGETHLFTASIDNSLRCWDAYNLKVLYGFEEKEGELSSMAYSAKHHRLLTGNENGSLKLWNIDNGQFFTTQVHRNTVSAILVASVGQHEFIISADFDGTIWIWEMAHGSFPPIPHCKIQTKEPNHDSEIFCLAFNAGDYLQTPHAAFFAAGDSNGDIRLYSLDDQELLTTLSNHEDSVTCLAFDGCFLFSGSDDHTIRMWNVLDPRRGYELGAIQAHDVAVRDLLILPSTGFVVSCAYDGKIRVWNYQVCGSSYGQYAAMVHEFKKPEKLRCLAYWQHKNAIVCGTSDKNVLVFDIPKSVRHGMVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XVV1</accession>
    <name>A0A6G0XVV1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mediator of RNA polymerase II transcription subunit 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mediator complex subunit 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MED9</name>
        <name evidence="8" type="ORF">Ae201684_001088</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the Mediator complex subunit 9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XVV1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001598"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011425">
        <property type="entry name" value="Med9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07544">
        <property type="entry name" value="Med9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0010">Activator</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0744622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="120" mass="13533" checksum="9059B89B4908F89F" modified="2020-08-12" version="1">MSMEQSEEAKKMHEEFDMLPLLIDILKDILTAGTNQEATRLGDVSATALALKTKYDDAARLLASLPGVDVSLDGQQEEIRKAKEQLRQKSEMMELYSTTLFRGTDEPRAQLNDVFSRKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XWE3</accession>
    <name>A0A6G0XWE3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">KATNIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_000734</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000008">
        <property type="protein sequence ID" value="KAF0744828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011720"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22265">
        <property type="entry name" value="UDM1_RNF168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026704">
        <property type="entry name" value="KATNIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027859">
        <property type="entry name" value="KATNIP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21534">
        <property type="entry name" value="KATANIN-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21534:SF0">
        <property type="entry name" value="KATANIN-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14652">
        <property type="entry name" value="DUF4457"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KATNIP" evidence="3">
        <location>
            <begin position="460"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="KATNIP" evidence="3">
        <location>
            <begin position="772"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="domain" description="KATNIP" evidence="3">
        <location>
            <begin position="1054"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="212"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="365"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="626"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="751"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="985"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="306"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="640"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="753"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0744828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1463" mass="161415" checksum="AB218A168A176E8E" modified="2020-08-12" version="1">MSDAHRKERKWSKPLTTIPAAEPKSTPLSAPAVEKQMEYIRALEEKNRLLKKMEETSKSDREVQNRVKEVGFTTNFNGENAHRKQKHARQTDKARAKSAGPTKLHSSSARIPAKHEESKRTVQSTGALPLHTARTDSESKAPPARQKWSKPQGIAEQRDGRIVFSQVASAPSTGDSDKEDGDSYLDESFEEFDEAASSPKSSNSPKIIHAVKPASDQQPSTFVPSETHGDKSSSNGQIPVNIQSLLHGMTKEKQNELMGFLQTFTESNKQPSDVNSLRQSIGDASLWNQLTVPIAQLTKIHQLDWEEEVQRKLRFEREESERLIAQAEARRVEMLKKFEAEEKELETLMLQRRQETLKKLQEMTLSTSLTPPTASPSTSMPTVQSSEAPTTTAASSQATKDPVVIAVPVKAPEAPIAVAAPAPSASPMKEQLLPPQISPPTALQMSMELPPAVPAIQSTKTDSSVSFPPPTTFELRFKLLSSWGQTQVIGLTQISVYDMEGNELNVIPDSLRLFSGQADAKPIPKSNNMVRDLAKLFDGLAHTTNDKEMWLGKQIDANPLQIAFSVAAVPSKVCVWNYNGKLHACVRDMEVFVDKQCKWSGSLPETFGSEDDHTCTWINVSSSVRKKPKEVKPQAPPQPATSEQSSTEQPADSGPIWLTKNASASSMPKPLDFSFIASEAKSQEAALSDAKPLTTSRRRLIDTPKENECREPPLPVPPVVPQFTSTLQSSWDTLEHFKRSNKSRLDTAECKESTVQPMSARTASKSSLDKLRPPTTTAALEANSKPAIPILPRGRTLVLECFTTWGDPYYIGLNGLDLFDDRGQPVKVSSPQNQVRAVPASINVLPEYASDKDPRVATNLLDGVNYTCDDLHMWLAPFSPNQLHTVTVEFDAQVVLSMVRIWNYNKSRAHSFRGVKNARLLLDNAVIFQGEIRQAPGILGAVEQCCEVILFTTDESLLAKIEQVDSDPTVDATLDVVHDICTIPRPTTAEEQNNRRPKTSAVNPRRLQPPTLTNNSEFAAAKHDEPQDSVSVRDTVRLRRQPSSELCGRVLKLVIQSTWGGRHYVGLTGITVWLVRHNQVISMPLSLAQLDATPRDLNSLGYTGDPRTLDKLIDGVNGTCDDTHMWLVPFEGRKAEVTIRLESPSDALYGLDVWNYNKNAEDTSRGAKVVTVVLDDRPILNCVLRKAPGVAFFDFKQTIILDEWLKGPLPGVPAIGSSSAYKNHLIRQDYEPPLHPSGFLLKFVLWSTWGDPYYVGLNGFELYDARGDKIPPPTVIAASPSSLADVDVKNDVRVPENLFNGQNNTWDAGDAWLAPLASSLGRPEGNIVVAAYDMPITLSMIKVYNYSKTPDRGAREIEIYLDDLKVYMGTLRQAPPAPGVARTGKPQQAVEFGQPILFTLNPAQVESEKRKVLYCGGEDQDVLCINEGQVVIESKAMYRAPDPGAEGVFVDLAKRPTTSLGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XY90</accession>
    <name>A0A6G0XY90_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_000029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000001">
        <property type="protein sequence ID" value="KAF0745574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XY90"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004169"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0745574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="24621" checksum="3EDFD7B859399CF8" modified="2020-08-12" version="1">MTASTNLEASTPSETCYIAEPKRRAWYDGNFSFWWLLGGVLGLWFTLYKGFGILFSLLPSSSGMKVGPFFAIHLVTAALFLAICVYNIFHTPSHGGSYRAVHIILGRMAMIAGLISFGCGAVTAWWERYIGLIGFAIGITAGGVFQVCAQLYGWYQIRQNRDVQKHKTAMLATFFFGCLIPMWMRFVPLLGGSGQLSAWAPPTAVAVGIVIGLLGLRAANKNKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XYB3</accession>
    <name>A0A6G0XYB3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_000065</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000001">
        <property type="protein sequence ID" value="KAF0745612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XYB3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011484"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12872">
        <property type="entry name" value="SPRY_Ash2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037353">
        <property type="entry name" value="ASH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598">
        <property type="entry name" value="SET1/ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598:SF0">
        <property type="entry name" value="SET1_ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="4">
        <location>
            <begin position="15"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0745612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="251" mass="27585" checksum="B6D9B0403F509528" modified="2020-08-12" version="1">MKEEATPVKRQRLEEPKKDESTAPATPPVPEESKKAVRWVEKGPLLVLGEDGLTVSGTKGYCMARTNASVKNGMYYYEIKLLPSTEPYHVRFGWGMKKADINAPVGFDEYSYAYRDIGGVTVHRSKRSEDYGESFVVGDVVGAMICVNWEENASKPTPEATPQTLPGRFVPPSLVKQTSDNAPTPLRIDKASYIRFFVNGKDQGVAFEAMPFGEYYPMVSIYGGGSITANFGPTFAYPPPSDAKPVPPDVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W566</accession>
    <name>A0A6G0W566_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_019055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000382">
        <property type="protein sequence ID" value="KAF0721588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W566"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015141"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0721588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="140" mass="15606" checksum="58A8830C748FF50C" modified="2020-08-12" version="1">MTNTIQLRADYPVTIGQPIANVTSYILDDKQRAVPIGVVGEFYLGGVCVSPHYINLPEQTSQRFIPDPINGGQMYRTGDLGRMLPNGDFQILGRQVKLKGYRIELEEVAEAMMQHPKVVSAAAVVKDPSRWLLFPQRCCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W575</accession>
    <name>A0A6G0W575_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RxLR effector protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_018580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000341">
        <property type="protein sequence ID" value="KAF0722248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W575"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001595"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026198921" description="RxLR effector protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0722248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="14766" checksum="82C132499F87B4D4" modified="2020-08-12" version="1">MRILVHLVLAASAAVAFNQSPQDSSVKLTTEQAPVYRALQDHRILEGEASAASPNTRRLTKRNWLTSCFKGTCRRNPSARGQGSPQRPQTPPRPQTPPRPQTPTRQANPGRARPSGMERQDTILESEKFDSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W5E0</accession>
    <name>A0A6G0W5E0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleoplasmin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_018596</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000343">
        <property type="protein sequence ID" value="KAF0722214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W5E0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016306"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.340">
        <property type="entry name" value="Nucleoplasmin core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041232">
        <property type="entry name" value="NPL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17800">
        <property type="entry name" value="NPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoplasmin-like" evidence="2">
        <location>
            <begin position="4"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0722214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="216" mass="23830" checksum="0448D94B04E859B4" modified="2020-08-12" version="1">MVHFYGAHVTEGKAVSVSVPEGYVLNVVHASLASGSAAVLSVETTGLDQSLVKVVVGTLRAKTCDQIKLDLVLGAQKAKFSVTGDGVVHLSGYHQPGPPELVEDEASEINRLSVADLTDLIQKAAARIPKEHADELEGEEEEDEKNQESTTQKKRPHETTWDQDEDSDDDDDDESEDVAPKVPRKPNQKPQANNFNDPLKRKRKKKKNKKLFQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W5P7</accession>
    <name>A0A6G0W5P7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_019158</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000427">
        <property type="protein sequence ID" value="KAF0721380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W5P7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015312"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000904">
        <property type="entry name" value="ABC transporter A family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF36">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="441"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="475"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="520"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="584"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="980"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="987"/>
            <end position="999"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0721380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="999" mass="109962" checksum="9E97DDB736A0A40A" modified="2020-08-12" version="1">MAEGELRCCGSSLFLKNRYGAGYNFSLVKTDHCNTPALIDFVQHHIGDDVKVLSNVGTEISFQLPLDCSHLFAKMFAELDDKLDELGVLSYGISVTTLEEVFIKVAEIGDEFHQHTQQKTDSMANAGGPHHGYRLTDHASQSMVAMFFIHFWALQEACSYRETSLNRNDSAIALTTSDYPSQSNTPLPYLCESDWMCDSVNQITQAVPQPLTSIGSPVYSTSTPTVFGVQYTNITATDPKSYSLKVGEEVFKRGFGVDTSPVQGQYGGYIFIGNSQTRTFGYNVAVNTSAVHAAIVYKAMRDEALYRTVTAKANLKVTCTDAPLPLTDASKIVFTTIVAFSTSMFVVLAFAFFTASIVPLPAFWLSNFAWDLLLYAVPRIFGLLAIYIFDITPFTGHNCSSCPSTPFAALIVVFVLFGFAIVAFCYILSYLFVEPSASQTYIIMIDIVIGVILMAVSIVLDVMDSSKDTNTQLKFLWRLSPLFCVGNSLNALSMASLYMAQGLISKDTSAFSTDILGWEIVYLAIEAVVFPLIAIGIDYALSFPKIKAKVTKDPNVVDALFEVDEDVQREELRIASGAADKDAVVMKNIRKVYKGGKVGVANLSLALPKGECFGHLGINGAGETTTMKIMTGDDLPTSGSATLGGFDIITQQLEVRRLIGYCPQFDALIDLMTVREHLELFAAIKGVPSGQIGATVKDKMEQMNLNDFEHKLAGTLSGGNKRKLSVAIAMIGSPPIIVLDEPSTGMDPVSRRFMWDVIADISTRSKESTILLTTHSMEECEALCTRVGIMVGGRLRCVGSIQHLKHRFGDGLMMHVRVAHVTSAEVERFSREAFASETIIAKERVAEVCSILGKPHRANFITSSHATGYVLAESLTRHNHIRAHEFYAWWLCEDRFDAMSEYLHQTFGDSNVQVLERQNDVTRFKLLGAKRTLALSNVFSVIERAKSNLCIEEYTVSQTTLEQIFNSFAAQQTQETGVARGMQGAIKGERNDNYESLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W5Q2</accession>
    <name>A0A6G0W5Q2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">THH1/TOM1/TOM3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_018494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000337">
        <property type="protein sequence ID" value="KAF0722367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W5Q2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014523"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0722367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="36218" checksum="60476577E2BB5DB2" modified="2020-08-12" version="1">MRQLLTDVDGVIEHELMLPVYVVALSLSTGMCITTCSCVFKWTNVWRDPGHGTMFMLFLMLGLWSFSLLLITFAVFLNYRSDSLEHPLTLNFSIASEATFVATSLWLLVAMYEVRRRVMNPRPSFPAAKNHMRWYCLVIHGFTLALVIVLVVFSQTHLTYTAPDGAQDSLVSWLVSYITWGTWALRLVSLLYAAIVAVALQCSKKRVIDQPRGLLAIVNVFFLLNMPYLVIAPMAEIRARTNAPTGLIDSPWALSIMKALAFCSGIILSLIMGISVGSFDAFYAAKIPATVANGRSKPLTHVQTSQDIIFILGETSSARSTPVENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W638</accession>
    <name>A0A6G0W638_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dynein regulatory complex protein 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_019081</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000386">
        <property type="protein sequence ID" value="KAF0721563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W638"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003655"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044782">
        <property type="term" value="P:cilium organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042618">
        <property type="entry name" value="IQCG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14871">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14871:SF1">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="125"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="247"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0721563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="396" mass="45603" checksum="87AC8DE7087BEDBA" modified="2020-08-12" version="1">MKAAAAPASGYRLSPIEATRASAILEETIEKLSFLGSITPDILQHREELSHVVGDEISRIIQEQRRLEAKYESLISQRSVLKGLANKSKFKENQREIQEVSRALRESTRSLCRNLKDNPNFGGNLMKIQNERQALIDLLTDTTRELKSCTYDSLVAFVTEGKHAAQKAADLIETEKEATEEVKRLTQELAREKAEHTREVAEQKAAILQLKEQLLQVKSKTQIDIRYARNEAKAKTASTSRLYQQLVAEQREKIDALAKQCESETRVHQETVSFLRSKHELLQQEFAHWSDKYEADYTEKQRELARLTDERAANLVKLEGLQKRWVEEVELQKNKENEKRRLKELELLKKEEEKKQTIAARKIQAAYRVHKAFLDEKKKAAESSKKKKGGKKGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WAI3</accession>
    <name>A0A6G0WAI3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_017027</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000275">
        <property type="protein sequence ID" value="KAF0724247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WAI3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007831"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF57">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="2">
        <location>
            <begin position="41"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0724247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="459" mass="52113" checksum="2C69E9445606B95A" modified="2020-08-12" version="1">MGVEGKAKQTAWKRILRWETQRARIEAAVADPATANKRTDRAKGIATTLSIEDEENIAIWVAQLRADGVPISNLMLKCKALEIARDVGLSPNDFKASPTWIRGFSKRWALSMRAKTRSGQANYEDGERALAELTSRLGKVIEEHGIEDIYNADQTGINYEYLPTHTLDATGAKSVWIKCAGRAKDRVTAMLLADNKGIKYPLFLVLKQPKSKIKEVVQENLIHRNGFGMRTWDDIQELHERHPSLLYANPTAWWNSIISVEFLKYHFGHRRGQDLKKVLLLWDDFSAHFTDEVVTCARDLNVILEKGPPTFTWHCQPADVAWIKPMKAILRGKWVNSLREQIANHGGGGGKSFRLECPDRFNLVEWVNDAWDQIPKETILKGFAKWNIPCLTMDETNQDLPTDEGVLDANTLRHLTDNHEVDIEILNNTSDIFQNDIPIEGNQQCECVAFERSSFPSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WBC4</accession>
    <name>A0A6G0WBC4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_017275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000292">
        <property type="protein sequence ID" value="KAF0723894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WBC4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020776"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0723894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="185" mass="20685" checksum="EA409F8E147E776F" modified="2020-08-12" version="1">MRLQSHTMSSYNDNSNQAPSAKRLSTTLLSPTSVDEIRRDLARAQRRRHRVTFSTATTFEFPVAFGASAIPKERGPPVGMTQIHSNMYTADISNTTECKRGVVMKFENLELIALLKAASVDAHEIAAYCREAAKIRQSRQEAAQDEHRARRRKRDAASALLQLAGYDIVEPSYKRRRACSTNSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WCC7</accession>
    <name>A0A6G0WCC7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_017307</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000292">
        <property type="protein sequence ID" value="KAF0723927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WCC7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016087"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10527">
        <property type="entry name" value="SET_LSMT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1420.10">
        <property type="entry name" value="Rubisco LSMT, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036464">
        <property type="entry name" value="Rubisco_LSMT_subst-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="4">
        <location>
            <begin position="28"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0723927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="810" mass="90731" checksum="3F019114765B1BEF" modified="2020-08-12" version="1">MYIPPSPSSTMKLRAFETWILDNGGKIKNVQLAQFDGMGTGVLVTSKIREKDEILYIPRSIIICRNTVEKLLPRKFLQAGPHSDDDILIAFLVIEQRKGSASKWAPYLNVLPESIPTSLAFTNAEVTELQDEELADMVYSAQATARVAFDALAMKLSVVLKKQNAVLTMEQFVWAKAVLNSRALTIRGQRFLVPFADMFNGHAHPDVRASNNGARFLDFHVLSNDAVRIYADRSCDSGAQLFEDYGDSDNYVFAFHHGFLMAENPFDCVRLPLPKPTQAQSQLLRSLGVLPQPHVCMQPNGETVYSLAQVEVNSLSQLELEACRGSASCIDARDKSKLQRYLSSLTASRLEAFPTSVDDDVAILLANTTTPAMRLIVDFRLSRKMLLRRLLETLSTPTPSTTSAATSTTPQYSTEEKLDRFHRWIGAAGCTPNKLKVAYIGNGYGYGALATDTIAPDEVYLGVPTSIVMDSASARRCPILGPLYVSLQASTGNRDAFHELLLHLMYEKFVRRETSFWAPYLALLPQPEAEIDVPLFFTPNQVDALAPALDFHDAVLTYRDNVAKSFAAIDRIVLSKHSSIFPRDIFTRANYRWARYILDTRSIWWLGERRLVPLLDMVNCNENPVDPMRVHATTLSSDGKSAITKASWEFPRAAQVFENYGQPNWIYMLYHGFVLPKNSHDCVHLVMYMDPAIVQANDSLQIRIVRAVGSFKPEFCLKETTLTKAVMQAAAVYVDVMAMTDPSYKVNHGVDKSRQAIAALRLVLTKRQSSLESISGLQDNSMIRMYMEQQHQMLGRLVQALDQKLDEPLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WCN0</accession>
    <name>A0A6G0WCN0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">CBM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_016296</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in degradation of plant cell walls. Hydrolyzes the feruloyl-arabinose ester bond in arabinoxylans, and the feruloyl-galactose ester bond in pectin. Active against paranitrophenyl-acetate, methyl ferulate and wheat arabinoxylan.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the faeC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000248">
        <property type="protein sequence ID" value="KAF0725211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WCN0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019990"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043595">
        <property type="entry name" value="FaeB/C/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38050:SF1">
        <property type="entry name" value="FERULOYL ESTERASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026210967" description="CBM1 domain-containing protein" evidence="11">
        <location>
            <begin position="20"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="12">
        <location>
            <begin position="19"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="59"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="61"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0725211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="331" mass="34125" checksum="1FA1CAEF92ED064C" modified="2020-08-12" version="1">MKIAGVLAAVASSAALVQGQVALWGQCGGQGYTGSTTCAAGAVCNKQNEYYSQCVPGSNVPSSNPTTATPSTPSSAPPSSSSPPSSSSPPSSGGNKSAGCGKAAGITSGTYTIQVNGKSRQYIVRVPQNYNPNNGYKLIFALHWLNGSMQDAVAIEGGYYGLQALAKESAILSPPMISTRAGAILAAKINLCVDTKQVFSTGFSYGAGMSYALACARPEKFRAVALYAGAQLSGCAGGTKPVAFWSTHGVHDSVLPIANGRSLRDHFLQVNGCQAKTAPEPANGQPHTKTVYTCSAGYPVQFYAHTGDPKDPGQSTSWAPAEVWAFFSQFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WDB8</accession>
    <name>A0A6G0WDB8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_016202</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000244">
        <property type="protein sequence ID" value="KAF0725305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WDB8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005214"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000027">
        <property type="entry name" value="Heat shock transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF206">
        <property type="entry name" value="HSF-TYPE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="9">
        <location>
            <begin position="3"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="151"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="111"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0725305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="237" mass="27667" checksum="A972CC33307CE9FA" modified="2020-08-12" version="1">MIDTSPAAIAGWCHDGASFVVREPKQFAATMLPKYFKHNNFSSFVRQLNFYGFRKSKKEVLLVAQETDDVKNSWEFHHDLFHQHKPHLMAKIKRKTNFSECSDTASNCDDVDQLRGEVTEIKSQLTTLTDQIANLSRLVHSVCHDTLKRSRVEETDADSQQQLHPSQRRIQQQHHHHQPSPPSQQYYFDNLQFVDVIPFEKTPTEYTNPLVEMQMHQALLETFVPLYTKEEPYKIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WEN0</accession>
    <name>A0A6G0WEN0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_015866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000234">
        <property type="protein sequence ID" value="KAF0725713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WEN0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016892"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="60"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0725713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="327" mass="35852" checksum="E47204C59C9CEA02" modified="2020-08-12" version="1">MDFSWSMQSITNRILRSAIETLMLNGRRSRLGYVNSAVSAGGYNWSFLEKSSNDDTKPVVVFVHGFSSEKDSWLNVAAHVTSARVLIPDLPGHGLTSPMSPSDNFGAMQQVRNLKSFLDATVGPDTPVHLVGCSMGGLISGVFAATYPEKLHSLTLVCPAGISMPRKSPVLRLYEDEGVNIMRGGTVDELVDMIKYTSHQPAGAVIEAPTGMRRIFFSLMASYRAERMPVIEKILTDMMRDQTALEENLHRIRAKTVLLWGENDKILDVSCLERVQGKLKADTIVVPQCGHLVQHTVPELCASVINRLVEETSPVPSEELASNVSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WEN8</accession>
    <name>A0A6G0WEN8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_015663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000229">
        <property type="protein sequence ID" value="KAF0725998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WEN8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000219"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001720"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0725998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="415" mass="46769" checksum="C084003177821A8C" modified="2020-08-12" version="1">MSGLSFVAAKGVHRHLRFPDSGERSPIRACVTDHMKITIKNWLKDNPSRKPKDVYNKLEAAHARNEFGQSPMPSLKQVQEVVKYMRRKEMRHQSTVQATEELSRRKPSDGIDNEHEPFVFGVPMIDGQPKKLVDRVPFVHPTDTRSFVVIQNTMNQQSDTSKFDSFKESMSSGIDTVTSWSPKRFQIAMNQQSDKSTFDSFKESVSSGIDTVTSKPDNMTSKMHSSDKSSDPSRSLEQLDEFEGYTLVPETEGSDIRELQTRSASSPTYGTSHEEGKGIRPSSTSAMYVKIKNSDFGHDVKDKTSNTMQSPEEGTKEWRKNTKESASDTGSKMKDKTAEKMELMKQGVDDMTKKVKDSESQARSTMQTKREEMSDKASDNMVKAGNKVDECRSKASNYGSHVRDKAEETLRQAID</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WEW0</accession>
    <name>A0A6G0WEW0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_016514</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000254">
        <property type="protein sequence ID" value="KAF0724954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WEW0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015352"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037869">
        <property type="entry name" value="Spp1/CFP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174:SF1">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="7">
        <location>
            <begin position="200"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0724954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="339" mass="38489" checksum="0EDB1374FB76AF3D" modified="2020-08-12" version="1">MCEIEGRRLCQNNSEHPRSLEEMEAMLKRLIQLPAYPLEAVEILETWKRAQKWTDEVTKALAMKIPFSRALALEADGEACGIPPSSILKRQLNGRIQDTKRWLARTRALFKFDSSSMSFSLQGALEKNDLEDEKLRLVCTCQQVFNDKVTFVRCCGCSGLFHPVCVGLDPHGSLRSSYLCRECCHLRRRTYPHNFPRSDAVYCVCRESTDSVPMICCDFCDEWYHAKCIGISPTVMSNLEAYRCPGCAFRQGMSHLTSKRPLRPSLKQMIGLITRGDALQIEVPELEDLKALVSLGNDLLAEIIDFERHFLHQCSLEPMLTTCRPIERNTGQSECSSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJY1</accession>
    <name>A0A6G0WJY1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Biotin-protein ligase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_014386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000193">
        <property type="protein sequence ID" value="KAF0727558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJY1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009725"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019197">
        <property type="entry name" value="Biotin-prot_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09825">
        <property type="entry name" value="BPL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin-protein ligase N-terminal" evidence="1">
        <location>
            <begin position="58"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0727558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="237" mass="25628" checksum="FCB6AC5C1B1F03E9" modified="2020-08-12" version="1">MTNAFTRAIVFLNPKNENPTCSHDAAALLRRLGIPNVQVVSLEAVHAALGRIPASEIHRALYVQPGGGDDVDVSFANYFKSNRKLKPAVEAFVAKGGAYLGICLGTYSAAAEHFDLVRDAEGDSFFQFDELDDDDAKILQIEVDGKRYGTYHQGGPDLSPMLLVGGAPFGTYVGLDAPVGVVVPYKNGRGTIGLLSPHFEANDDWDDAKNGRRADDCTEPAHKFLELLATVNQERHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WKE8</accession>
    <name>A0A6G0WKE8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_014332</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000191">
        <property type="protein sequence ID" value="KAF0727708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WKE8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009179"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010463">
        <property type="entry name" value="DUF1057"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47533:SF4">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47533">
        <property type="entry name" value="PROTEIN CBG21859"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06342">
        <property type="entry name" value="DUF1057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0727708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="31623" checksum="0469829D0FA0F72B" modified="2020-08-12" version="1">MASPASAAKTVDKITLQNGHDVWYVAYGQSNALDTFVLIHGAPGSHKDFGKLAPLLTARNNTNVVAVDVPGNGRTSAAAAGDDGLSETRIVDAMIETAAIVASQEPQRRIFLVGHSFGGATAMQVAARCKLDALAGLALVNSTGFRPHVMARPFWLVRFLYKLLVWSPFTRFFMSWFVHAFLQNVGGFKLTKNEAIYTYHRIGTMDFAAIQASANVIAGAKLPVFCATALKDRFVEKEIGEEVRAVLKPVITNEIDSNDHNIQESRADELATGLLRWVASIPREKLIPGASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WKM3</accession>
    <name>A0A6G0WKM3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fibronectin type III-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_014234</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000188">
        <property type="protein sequence ID" value="KAF0727798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WKM3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019124"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009044">
        <property type="term" value="F:xylan 1,4-beta-xylosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044993">
        <property type="entry name" value="BXL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721:SF3">
        <property type="entry name" value="BETA-D-XYLOSIDASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721">
        <property type="entry name" value="SUGAR HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026078373" description="Fibronectin type III-like domain-containing protein" evidence="5">
        <location>
            <begin position="20"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="6">
        <location>
            <begin position="649"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0727798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="739" mass="79986" checksum="E8F09A734EF8663C" modified="2020-08-12" version="1">MRSAGTVAAVAALAIGASAQDNLGVCDHAPQKSLPFCNPDLNIDERVEDLVSRIRDQDVPGLLADNSSGVHIPNVLDLPPYAWWNEGLHGVASSPGVIFEKPTIAATSFPQIINLASSFNRTLFHRIGQVIATEARAFHSAGHAGLTFWTPDINIFRDPRWGRGQETPGEDPFLTTEYAVQFVTGLQGNSPFLQVSACCKHFSAYSQEIHRHELSADVGPQDFADTYFPVFEACIKRANVSSVMCSYNAVNGIPSCADKHLLTDIVRSKWGFDGYIVSDCGAVYDIQFNHNYTNTTADTCAKTLEAGTDLNCGSFFQQYLGDALPKVDRQAVRRALRMIFRTLMRLGYFEPHDRQPFSHITIADLDTPEHRALALQAAQQSVVLLKNDAKTLPLDPDAFDATHRLVLLGPHVHSTIAQLGNYAGTPSFIVSPAEGVSKFVPAANTDAAEGCAILGDDLDEKAIELAAVTATSQVVLFVGINQTIEAEDVDRTHIRLPGRQSELIRKVAAAAAKPIVVVVLSGGPVDLLEFKQDPKVGAIVYAGYLGQSAGTAIAQVLFGEVNPSGRLTHTFYPASFADQITLEDMHMRPHDKSPGRTHRFYTGEPVFPFGHGLSYTSFRYGLHAAATRLDGGVQVTVAVANVGELIADNVLLCFASPPSAKGRPLQTLVAFDRVDGIVPGHVYLWKLSLPIESFALSNEDGKIEVVEGKWTLHIDGVTFQVDISNHGNTTVPNPFLANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WL60</accession>
    <name>A0A6G0WL60_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_014053</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000183">
        <property type="protein sequence ID" value="KAF0728046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WL60"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013191"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0728046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="478" mass="54172" checksum="527F2E634F1BACAF" modified="2020-08-12" version="1">MGKDNTAPLERTAEDRKTALRQYFTRKQQELAHLQNQLSELPPAKLIASRDSKGENNHLQAVVDANTSLIYEMTSLLRDSQPRPTASISFVQPAHHYVTLMANSNVRAQAKQWLVQQLYHNTDRFFHNFPAISLSEEFADCKAECTGPWIHTVKHCQAIWPNTVEEIKQLFLHPNSQALICGTYEFDVERDGNAVLTRGIFESKWSWHHLQGHFYEADRFVAVFRSLNNDETLQDREDPNFYSMEWLDVRRISSTHSVVRMLVHRTLLIEDAKELIKSLGTVVSSRDSTGIEQEVSAFEKKLQRKCHAYLQCNSSPGPPCPSSSSTRCQESIVNSNAELVTSQRPAWIQGTCSIQRIKRAAGSVPMRFLPPVLDQAALLTLAQPSASQPPHCQEPQLLFPRSLTLISSHLSSHSLSRLTWMFIATNAQSFLNTASCAWTFNDAAMLSLNVWIDLTFVQQYGYNREIQVEIMDAVSIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WM74</accession>
    <name>A0A6G0WM74_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BED-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_013759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000178">
        <property type="protein sequence ID" value="KAF0728395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WM74"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002380"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="431"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0728395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="653" mass="74860" checksum="5EF969A97DCC64F0" modified="2020-08-12" version="1">MGEPGERVGTQRTAHLWKHFIKRKDLGKYYNNWRVECRWCRQAYDNRKDDDTIPEPKVLISTTIKMKAHLKQCDYADINELGVIHSPTPLVKSSSAPKRHKTKKTTEPTSPLQPSSRIDPSDEQTLPYSTAYIWAHYTKREDLGKYHNNWYVECKHCRRAYDEQTDKTTAKEPTVLISAMAKMKTHLKKCIHIPREDLLAFHEINQKMVPLKRRRVDKHDKDVQDDNSDKPQPDDDGSIRVIVVPSHKAEEPFWLARVVAEPRKDDECVDITWLSRSSSGTYVVANDDSIPISSILCQVVVTEDTPGEFTLSNPSVDEIHQGLNTVDRPPFSFVKTEKVKTNPPRSYLKKENSATAGSGGHEGGRRHPIWQFFTKRVDLGKYFTNWYVECNFCLSAHQANPDVVQRPPTMRSTIPNMQVHYDSCPNRPHDASTAPSAAPAGGASHSKEVMVAKEERLPWRCLWRHFAKRVDLPRYYFYVQVECRHCRAAFPSKTSQEPDVMISSPPLMRQHLRDCPWINFDDILDHDQNTNNDDVDDTMDKQHHEAPPSPSSVLYEAMAFTAIRCDQGFWIAQLGYDVTSAMMDKGDTLVEVTWLDRASDGTYAFTVDQEIPVHTIVCRVQLVHEPSSKNGGEGAFHLARDELLRIETIMRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WN00</accession>
    <name>A0A6G0WN00_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_013651</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000175">
        <property type="protein sequence ID" value="KAF0728693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WN00"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003184"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35213:SF3">
        <property type="entry name" value="MYB-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35213">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="130"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="38"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="406"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="417"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0728693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="570" mass="64408" checksum="40130DD64FD66DCC" modified="2020-08-12" version="1">MSYEQQQQQQHMHTMTYGYPQHYDQLGMEIPSYEHHPNVVASTSSSSSMNGGMHMHHHQQMQPQHNSYGYQGPPMSLKRKSPMYQDQQPASNPQFSFAHAAASMVEQQNPPPQQQPLLLESVSSPRQPNCDLCKYPDPILYVPTCGHTFHSRCVGEWPMTRCPYCHGEVAKVAVVHIDMTSKTTQRSGKWTKQEEKFVNLIVDEFDHGTFPLANGTPVRLVLAKLLNCSPMRLSKKFQKNALGKRTYRVPKNSASGARISFDAASHQARQIEFSAVESAFRQEVVLLQRKDNKQDGYIELRDLRLAVIQFWVSNFLKFALSVGQQVEGLDTTEPKKKKQAMQKLRDGMFDQVLSWGEKRPPSPPQPPPTLQSWEVPYFKSEPFKPYEDENSDDRDLNAGEIPFQPTIEYNKMPPQQPQQQHQQQPQLHHHQGAYRDPSPSSPSYAINAYSNQYKRPQTREPTGRMALTPLSMRAGAMRTLPETGVYDDQTSSPELDGLLMGNTPSNAPFRITQSHPPASTAPTPSTNPAHYDTMDSMPPANASWDQMLDDFAGINSTLSDPALNSYLQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WNQ2</accession>
    <name>A0A6G0WNQ2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_013278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000170">
        <property type="protein sequence ID" value="KAF0728977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WNQ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004837"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0728977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="483" mass="54759" checksum="2DCD96968AF4355A" modified="2020-08-12" version="1">MPLVHNGHVKPTGDSTNAAGPTEHLFRKAEIPQGLALNTSELKKTTGADQPSSEDDSMTRSETLECVCGLLYLVFTLTLSMYYLQILSPSMANDLWWDGFNASGVQSYLIDVYNSQLNLVGNQSASLDFTDKNYALEKDYTKFYTPIKFTPVYPRIVLDSMVYDLALAVNIIRQMVGPESVITQYCWVDLDRKWEVAHTALRQDRCKARYTDNGAVYYEPVIRLVNWKKWMNGNFGGNFNTTIGNSLRSTRRGQDWLDVTPLAFVNVETEVAYWQQKGIVKYAMQYINNFEWGMEETLAIQNAFGVTQDITIKRTAYNTRIASWTTIWMYFGPWNDLVFAGWYGYSFLLDNPNNQRFMAPCDYSDYLANPTNYSCKPCGAASLQDDSDCYADYEMFLNLPDSPGFELVHSNIGELNSIDLYFVRVPPSLSALYSTFQGLVSQLVLSSDEFATAMSKIPNLPSDPVPPAWILPDFMYMGDILCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WP48</accession>
    <name>A0A6G0WP48_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucosidase 2 subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_013129</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000167">
        <property type="protein sequence ID" value="KAF0729151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WP48"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004288"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017177">
        <property type="term" value="C:glucosidase II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039794">
        <property type="entry name" value="Gtb1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036607">
        <property type="entry name" value="PRKCSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028146">
        <property type="entry name" value="PRKCSH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630:SF1">
        <property type="entry name" value="GLUCOSIDASE 2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630">
        <property type="entry name" value="N-LINKED OLIGOSACCHARIDE PROCESSING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12999">
        <property type="entry name" value="PRKCSH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13015">
        <property type="entry name" value="PRKCSH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026070584" description="Glucosidase 2 subunit beta" evidence="6">
        <location>
            <begin position="23"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="7">
        <location>
            <begin position="377"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="290"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0729151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="493" mass="53976" checksum="DF70861284E799E1" modified="2020-08-12" version="1">MRDLNRKMKLSILAACLAGCAASVPQLHGLKPEFQAQVAAAASLNCDSGTKNIPIASVNDDYCDCRDGSDEPGTAACSHTQVQFYCENKGFFPSEIPTSRVNDGICDCCDGSDEYNSGASCPQTCATLRADHDKEKAAQDAVLEAGREARLKIVTTSKLQKEEQYRRRTDLEVEKARLDKAVEDARALKVSEEAIEVQEQKAAAVATRKKVAVHLGLHDLSSEQLIELVLDLSVKVPLRSDVLSAIRGVQTSDASVIDQQEQAYELTLAAHKKEVERVNQVNDDLKKAKEDARKLKEDAGETFEEENDDKYKPLEVPTPPERPIDQLFGKLTSDQSVPRPEAKAAREALDSAESKARETQSELDAIEKKLQLQYGPDDVLFSLRDTCVEVKSGEYTYKMCWFGQAHQDHTSLGKMEPIGPSPRLNRIKFSGGAKCWNGPERSLTVTLTCGETQELGGIEEPSTCVYVATLQTPIACSPEATTAPTSTPSHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WPB1</accession>
    <name>A0A6G0WPB1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_013176</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000167">
        <property type="protein sequence ID" value="KAF0729199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WPB1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012729"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0729199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="150" mass="17039" checksum="33B622B0F93CC706" modified="2020-08-12" version="1">MKLLLDLSSRSTVESTVSWLCKPVLDNKTHESDRLRFGRVMTLQWHLIARLDDMMKLSFGDLSYNPSHPSTLLCQMRWSKNITEEREAPRQIILASIDDRICPLLNLAVFIEYTNPTAEKMPFSMAMGQTTTGSCVNCCPVLLITAIFVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WQ26</accession>
    <name>A0A6G0WQ26_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Post-GPI attachment to proteins factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_012966</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000164">
        <property type="protein sequence ID" value="KAF0729468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WQ26"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010018"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021910">
        <property type="entry name" value="NGX6/PGAP6/MYMK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36561:SF2">
        <property type="entry name" value="HAEMOLYSIN-III RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36561">
        <property type="entry name" value="HAEMOLYSIN-III RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12036">
        <property type="entry name" value="DUF3522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0729468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="24352" checksum="E5BD39C771A5779F" modified="2020-08-12" version="1">MKDDVVEMAIMLLVTGVTNFSMLQTIVMLYRHQMLFEVGHEVVDRGLTCFMYHCCNSIDAPLYLDEGQWHRLDNIGAIVCFTNLCWYLMDLRDDQTLRALQYGAFGLILIAQEKDPWNPVYTVAPILLSLGAVVAVNFVRGMPKYDKTAFAQGFLAMFVAVLCFARGLDDATDPFRFFHGCWHACVSLAMNYFFRTLSPPYVRSSLLPTDAKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WRB6</accession>
    <name>A0A6G0WRB6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_012581</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000159">
        <property type="protein sequence ID" value="KAF0729942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WRB6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009822"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
        <property type="entry name" value="FYVE_like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="5">
        <location>
            <begin position="255"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0729942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="404" mass="45694" checksum="3558C2B2DC15A377" modified="2020-08-12" version="1">MVLVNSMLHVAKAQVQGAQRQQDWMLCADEKDVKIYRAEDKVHTSTHGTMYMYAGTTQVVGAVDEFVALFKNETTIEAKEYCRRFANRLMDSVVLYALVKPSEEQPYERIGINWRAFESWGGKLFQNRDSCLLECHHEFYVGSRRGWVCSLISVDLECCPSLEDTLGLVRQCDYGSGHVVLESHRRGYLDVTYITHTNVGVGKSEWIYNSLGQIPRLAEISLKSRVRHVSKIDRFLREDRLSRTPCLDMEAFMPLDAVASCCLCSKKFKRWSQRLNCWKCGIVTCRHCSRAWTIKQHGFPVLTNVCTKCSLCQMLDSGDFNTMYDPMMIVLDGSEASTTPHPAIMLFGSELSTDNSTSATSNWNLLPTPSDDTNLCEYATSVTSLTSTDFSAYCETDIATPQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WRW3</accession>
    <name>A0A6G0WRW3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Folate/biopterin transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_012191</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Folate-biopterin transporter (TC 2.A.71) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000155">
        <property type="protein sequence ID" value="KAF0730184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WRW3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014514"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039309">
        <property type="entry name" value="BT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585">
        <property type="entry name" value="FOLATE-BIOPTERIN TRANSPORTER 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585:SF0">
        <property type="entry name" value="FOLATE-BIOPTERIN TRANSPORTER 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03092">
        <property type="entry name" value="BT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0730184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="464" mass="51071" checksum="BFA4D90A249B2E6C" modified="2020-08-12" version="1">MARLFPDAALPWGLLALYFIQSFLQSFPMTAYGDWLFNEIHMSPATTNFYYALTFFPWNLKPIYALISDNFPIFGYRRKFYIVICECGAALSVLATGLFISTVAGAFAVKLIDSSCEAFTQMMLGVVLVDVAAGNREMSGYVQAWANAAKNSACIVALIVGIPIYASKSIQAREVICWTSVVPVAGIITAIYFFQENKVDVSDKEPLDSDKPQTLSELVSQKWTAFHSACKRIVSDQWSYFPVMVFFFLSSALPSGGSVWYQYTYSLLNNEKECLQYSSLAGMVGRVLSCLVYSKVCHGYSIRAVFGISTVLSVLASLPQVLLAPPMAHLPMSVCTFCTLESFVSAFAAEFALLQLLIVATYYCPNKATDGKGLTYALYLSFMDFGGVASSFVSAVFIEALGITQDPTTLVINWSNLAWLVLIGAVCRLAILAFLCLLPSRIEYDSDEQQKLISQDDAKQLDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WRW4</accession>
    <name>A0A6G0WRW4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_012173</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000155">
        <property type="protein sequence ID" value="KAF0730166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WRW4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006057"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007674"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000163">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="601"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="642"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="720"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="161"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="608"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="920"/>
            <end position="1146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0730166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1152" mass="127642" checksum="9468F688AD54E35B" modified="2020-08-12" version="1">MESDNAVYHSLASPKSDLPISKERPWREVPNPMGTSNWLIDALILWLEPMMFRGAKKTLMEEDVWKLTPGDTAAQLNARFDRFWKVEKTKPSPSFTRAMMRTMQGQWIYSVGVYSTYAVLNHVWLRPCRTTHVAVILVGDPDRLRPISRVQFGRQCQVDRYAKRSMTSGEIVTLSSVDSERLFQGFLLGPWVIVAPVNVAVIFVLIGFTLGYIVGIVGGVVMALLLYVGYTTATTAGTIRHEILKLQSERVKLTNEILQGVRVVKLYAWESFLEDQVAAIREQELILLKKFQYARVLNTVALSIAPTLSLALCLVVYIALGNNLTPSLAFTTLAYMNVARFPCIVFATAILFASEALASCRRIGDFLLADEIDDTKRIEAGDAAVIEIQDGNFSWHVGPNNCQENGENVDSAATPVTLNNINLSIKPKSLTIIVGAVGSGKSSLISAILGEIHQVSARVSIARAMYRENADIYLFDDPLSALDVHVAGAVFQDCIQNLLADKTVILVLNSHYHFLPKADRVLVMEDGRIVGDGSFDVIKEKFQHLNSFDDDVAKEDYVVVIPQAEASEATNKNGILVQKEDRAIGAIASSIYVTYFKSTGWNGLVVIVMIVVAFSISQATVVLTDWFMGYWAAHPGHNVRDVIVYCALALVSIVLMWGRSVYIVYLCVLCSRTLHAKLFKKVIQAPVNTFFDVTPVGRVLNRFSSDLDQVDSILPYYGVLVLQFGFQIAGVVVVCAATSPYILIVYVPLVWLFQKIQVFYNRTSAELKRLESISRTPVINLISETINGITTIRAFDMTRYFAAKSRQVLDHNQSYFMVYRTSSRWLQMRLDWVSTVVLAGVSFISVASKSSIGVTAAGLGLTYASQMSAFLSRVTMSSSMVENIMTCVERLEHYNSLDTEGDKCQETVVAPAQWPAQGTISFESYSMRYRDHLDLVLRDVSFVANSGEKVGICGRTGSGKSSLMAALFRMVEAATGCIKIDGIDISQVNLHALRSRLTIIPQDPVLFSGSLRFNIDPSKQVADADLWNVLKKVHLADCLEGGLDFQVAEKGSNLSLLCIARALLRQSRVVVLDEATANIDLESDRLIQQTIKECFRDVTMLIIAHRLDTIIDSDRILVMDRGSVIEYDSPQVLLAKEGGAFAELAKQAHVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WS88</accession>
    <name>A0A6G0WS88_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dihydropteridine reductase</fullName>
            <ecNumber evidence="6">1.5.1.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Quinoid dihydropteridine reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_012291</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.34" evidence="6"/>
    <dbReference type="EMBL" id="VJMJ01000155">
        <property type="protein sequence ID" value="KAF0730290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WS88"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021871"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004155">
        <property type="term" value="F:6,7-dihydropteridine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070404">
        <property type="term" value="F:NADH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05334">
        <property type="entry name" value="DHPR_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000157">
        <property type="entry name" value="Quinoid dihydropteridine reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15104">
        <property type="entry name" value="DIHYDROPTERIDINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15104:SF0">
        <property type="entry name" value="DIHYDROPTERIDINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0783">Tetrahydrobiopterin biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0730290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="234" mass="24019" checksum="587C0EEA13D0F733" modified="2020-08-12" version="1">MLKRLLVVGGSGALGRGVAQRFNAAKWSVINVDFAANKETNVTNVTLDASKGVLHQLPKVIEGLQNQKVDAVVCAAGGWAGGSIGDSEIASSLAQMYSMNLESAVLAAHVAATSLNPNGLLILTGSAAALTATPGMVAYGLTKAATHHLVASSAASLPTGASSLAILPITIDTPTNRKFMADADFSTWTPVEEIANQLLEWSTNTASRPTSGDLVQVTTSNGVSTWTSKGNPFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WT35</accession>
    <name>A0A6G0WT35_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_012077</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000153">
        <property type="protein sequence ID" value="KAF0730658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WT35"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011713"/>
    <dbReference type="OrthoDB" id="10056816at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10507">
        <property type="entry name" value="Zn-ribbon_RPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000032">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034004">
        <property type="entry name" value="Zn_ribbon_RPA12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF14">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="11">
        <location>
            <begin position="81"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="9">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0730658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="124" mass="13824" checksum="565CCA8CC8B8D02C" modified="2020-08-12" version="1">MDVFFAKNTSTVGPSFCPHCGTILDLPETNSIVCSACGFTCRYTDLPSLCTVTFSQDRPEPKWVKQDIQSQNVTGPARATVEETCPKCGNPQMEFYTMQLRSADEGQTVFYECKKCGHRYSVNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WTF1</accession>
    <name>A0A6G0WTF1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Telomere length regulation protein conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_011826</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TEL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000151">
        <property type="protein sequence ID" value="KAF0730711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WTF1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000881"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.720">
        <property type="entry name" value="Telomere length regulation protein 2, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038528">
        <property type="entry name" value="TEL2_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051970">
        <property type="entry name" value="TEL2_Regulation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019337">
        <property type="entry name" value="Telomere_length_regulation_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15830">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15830:SF10">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10193">
        <property type="entry name" value="Telomere_reg-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Telomere length regulation protein conserved" evidence="3">
        <location>
            <begin position="459"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0730711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="719" mass="80608" checksum="B0FAE0CE98D1795A" modified="2020-08-12" version="1">MKAVCILLSMDPAFLVSCFEDVLIHALTVIGPAWITRQQLDFGNGAVLEALDAIFSLSQAKRLAGYHSNPIRTLVVALTRWNTADEIVSRIACRALEAFVQQDGMSALISELLQDEKATETVYELVLTKVCAIPALTHNVFRRDTPPCFTPSTYYSNLSRSFLKHHASRSQRLPVVTRVILLKISRQGHTREYVHEWINLMKTNKTIDLASFVQAIPAVCFDPLFSELFKELDKSGKFDCFTTTTQMDASAVTSTNFTACNYIQATSPTQSTSQFAHAQALGGPNLRSQSIFAIRKDIPSKCNESTARFLQLGLERIREDIPEPRAFLDSQGWTIYLCKGVQDHMSHSLLRIRHLGMRVASALSLILSPESPLVFEDLPPDDVQSVESTLTVQLAETSPTQGEVSPHLMLDRDDPDAIVHTDSEDDDNDDDVASQISLEAYDMSDDEETQNENMGKPLVYLFDVREGLMADDNREQVELALASLPGIIARQPHDLADMAIDLAKMLTRLEDAFNTPNFQQLRRESLAGLCTNVPQVVTPVLCEYVYDSEKLFQTKLDILQAVVDASQRLSALGKSPSTFFFPLLNPLESKLIQQSASTWNQEKYLLDDLLTAHVMHTLSVVLESTWKNSPQIPTMGKRFLALIWSQRNHAIPSVRRQVLFGLSRALLVLPTFVWSEEVERLQMRQDLVIYLQQEMQFDPDDGCRQAAKVLLSSVKPMIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WTG6</accession>
    <name>A0A6G0WTG6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Multidrug resistance-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ae201684_011853</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000151">
        <property type="protein sequence ID" value="KAF0730742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013384"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000006">
        <property type="entry name" value="ATP-binding cassette, sub-family C (CFTR/MRP), member 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000063">
        <property type="entry name" value="Multidrug resistance protein ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000610">
        <property type="entry name" value="Multidrug resistance-associated ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000997">
        <property type="entry name" value="Multidrug resistance-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="714"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="771"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="846"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="873"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="960"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="984"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="95"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="409"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="728"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1049"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF0730742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1294" mass="145480" checksum="A130DEEB5F722191" modified="2020-08-12" version="1">MARDTKYQSVATEKEQRREDAKSPLETENFISRWLYLWADPLMKLGNERQLEASDLWPLPSNSRCEVITTTFEPKYNATKSIFWATAREFGLEAVVVGILQFVAMVLSLYGPIVLNGVVSSIEQSSPDFKTLAIPIVSLFAVKIVQAILQTQTDLKNELLFTKVMGVLQNLLYKKALRLNAASRKAKSTGEVSNLFTSDMWPVVAVSFFINQVWIIPLQVTALMYMLWQQLDWAMFAGFAIMFISFFLTRWFATMQRTNWRVLMAKKDTRMKVINEVFGSMQIIKLNAWEERYYSKICDLRADELDSLWTQFCISAGTTAMNYIAPVALTTISFACYVLVLKQPLTAAKVFTALSLFNMVKQPMMRLPQIVAAFMQAAVSYKRFSEFLALEERDPTIVTDNVSANNVALEVVDGSFGWDAEKPFFTNLQFQVKHGEFVVVHGSVGEGKTSLCNVLLGELDKYQGTVGVNGRVAYFAQQPWIQNMTIRENILFGLPYDRVKYNRVIEACALQKDLTLFAAGDRTEIGSKGVNVSGGQKARISLARACYSEADIFILDSPLSAVDAIVQNEIFTKCFLSLLRDKTILLVTHSPEIIASRYIDRTIEVKDGKLIETINEDKQEFEALIPPYQARSLIAPAELDENVSDDVSIEAATLQYMDVLVSPSLKSPFGANIEAHLFTPFDENQPKTYDEDDSRGKLIVVEERESGRVSQEVFLAYFNAVGGWTTVFVLLFVQCLWQGLQISSDLWLSSWSASGANMTAQEFQDKAEYNISVYAGLAVGSSVMVVARVFTVSFAGIRASKKMFDDMTKALLGAPMRFFDTNPLGRILNRFSGDINAVDGRLPNQFGFFLSTVFVLIFSLGTTIAVIRTLGLILIPLMYIYYKIASIYVQPAREMERLNKTTRSPLITHISESIDGALLVRAFGGKQVRRFERLQQTKVNRNMETMFCGELASQWFSFRIQMISAFMLLVTTLSLISMRSYLNAGLVGLVFGYSLQITGQLEWMVQMWSMLETAMVAPERVAEYTNVDQEPPRLISGAVAGSWPEDGSITFENVSFRYKPKDPLVLKDVNFHVQSGEKIGIVGRTGAGKSSLTMALFRINDIASGKISIAGVDTTRVGIKTLRESMAIIPQNPILFKGTLRSYLDPFDQYTDEQLWTAIEKVRLSPRISQEEKKLESIIEENGENYSVGERQMLCMARALLRNCRIVVMDEATAAIDHETDQNLQRVIREEFSSSTVLTIAHRLDTVLDADRIMVFDQGRLVQCDSPQTLVSQGEGIFFELCQEGGYLDKIQVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WTM3</accession>
    <name>A0A6G0WTM3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Dihydroxyacetone kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_011740</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dihydroxyacetone kinase (DAK) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000149">
        <property type="protein sequence ID" value="KAF0730854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WTM3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019218"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1180.20:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10440:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase, DhaK subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.340:FF:000002">
        <property type="entry name" value="Dihydroxyacetone kinase, L subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10440">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.20">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012734">
        <property type="entry name" value="DhaK_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004006">
        <property type="entry name" value="DhaK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050861">
        <property type="entry name" value="Dihydroxyacetone_Kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02361">
        <property type="entry name" value="dak_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011049">
        <property type="entry name" value="PRK14479.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629">
        <property type="entry name" value="TRIOKINASE/FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629:SF4">
        <property type="entry name" value="TRIOKINASE_FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02733">
        <property type="entry name" value="Dak1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82549">
        <property type="entry name" value="DAK1/DegV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="DhaL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51481">
        <property type="entry name" value="DHAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaK" evidence="9">
        <location>
            <begin position="15"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="DhaL" evidence="8">
        <location>
            <begin position="374"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-hemiaminal-histidine intermediate" evidence="6">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="63"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR612734-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR612734-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0730854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="587" mass="61713" checksum="AC48758212B23904" modified="2020-08-12" version="1">MATASSSGLFKMINESTSVVDEMLQGLVHTSPHLSLVPEHRVVLHQDYQAIKQNQVTLLSGGGSGHEPAHAGYIGDGMLTGVICGGVFASPSMKQVLAAIRLVAGEHGCLIIVKNYTGDRLNFGLAIETAKAEGFNVDMVVIGDDVAIPGAKAGRRGVAGTVFIHKIAGAMAAQGYPLDVIANKLRQLAIGTMGVAWKSCTLPGQSTSRHINSNEMELGLGIHGEPGVRSASQKSSKDTVAELLETIHTDLGVQRHDSVVLMVNNLGSTTAMELNVIANDTLEFCRRQDLNVERIVVGNFMTALDMSGFSITVWKLDPMQQHALLAWLDFAVTAPAWPARTAQPFKANQLVNAPKETTSQPAPVGTSPLTAHGLLLKQAIEAAARRIIQAEPELTEWDSKVGDGDCGHTLKGGAQAILNDLASYPLNVPSLALHAIAATIGKSIGGTSGVLYTIFFTAAGTAMQTHDKGQDNSTVSTHGWVDSVGSGVAAIQKYGGALEGSRTMVDALLPALRAAKKAELGSYSDWLTSVEKAAYEGAENTKEISPRDAMGRTSYVGADFVKGVPDPGAMAVAYWIHAVVAILGATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WTX9</accession>
    <name>A0A6G0WTX9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_011538</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000147">
        <property type="protein sequence ID" value="KAF0730986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WTX9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016546"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0730986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="32877" checksum="907388ED68457C61" modified="2020-08-12" version="1">MTFLRLDGVFALYIVLFYIRVLCIEDMSVYEPLEQFIFPVLEGVAIFSFFNLMLYLVGSTEAAVRHMDPQGAGATSAAPEAWLASPSKKKLDNYRGRIILFLVVKPILGVVDGWAVYHEESHPDNNKYRIVHRVISAVSAILTIVTFVGLLLTYRALHRHIPASFQLVHKFIAIKALLVVSTVQWSIANMIVCDWDFEQMYIYSTICMGETLGLTLAFQNYFTANETDGVPRLETASDGSPTVPFQPARILASWDLFQYPIPANHSGERTQLRRVRLRQETSTSDGSCTTNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WTZ0</accession>
    <name>A0A6G0WTZ0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aminotransferase class V domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_011715</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000148">
        <property type="protein sequence ID" value="KAF0730953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WTZ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009305"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd24138">
        <property type="entry name" value="TtcA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43686:SF1">
        <property type="entry name" value="AMINOTRAN_5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43686">
        <property type="entry name" value="SULFURTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="2">
        <location>
            <begin position="87"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal" evidence="3">
        <location>
            <begin position="743"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="967"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="976"/>
            <end position="989"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0730953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="997" mass="109887" checksum="FFAD6B486085118E" modified="2020-08-12" version="1">MAATDEGSSDIASGATPVNMQPPIVASSTSAERMFCDELEEDLTPTTTENENATGLLKGEALLDHIRQGVIGRNSAFETPFGTRPLVYADYTASGRSLQAIEDYMQMEVLPQYGNTHTTTSITGLQSTCFRHETRQIVAQAVNAKITGRGAEDVVLFTGSGSTSAVVKLVQALGLHIPIAHGASKPVVFVGPFEHHSNLLPWRESSADVVSIPENAAGQVDLEVLRQQLALHADRPLKIGSFSAASNLTGILSDVDGITCLLHEHGALAFWDYAACAPYVNIDMNPVVVGERRPFVYKDAIFLSGHKFLGGPGSPGVLVVKKRLLGNPVPTCPGGGTVFYVTEEDHRYLSNREEREEGGTPDTLGSIRLGLAFELKQRIGVSTIMEREERHVRRVLDALQNHDRVVLLGHEFSQARLPIFSFLVRAGRRFLHYNFVCALLNDLFGIQSRGGCQCAGPYGQRLLGISKPDQRALEAALIDKTEVLRPGFSRVSFPYIMDNMEVEYILAAIDFVATDAWKFLPQYRFNHKTGEWKHRTRFTKFPTRKWLTRATFTATPAAAPTTLTTSYAEYLEQAKELAVQAVSDVRATPLSHAGMLDDSKASLRWFIYPSEVLAALDAKETSNLALGDLEGPIQPHLYGAPSTPATPAAPVAVAKSVNSTTAAAAAVCLTCPPPTKSEKYPLRNQAAVDSNPLQGLQQAIASTDKISVQVSTTQLFPQPPKKLMRLVGQAMMQWKMIQDGDRLLLGVSGGKDSLSLLHILLTLQKRAPVRFSVACATVDPQTPSFDPSPLKEYMKTLGVEYHYLSDNIVERAACEMEGDSLCSYCARMKRGLLYTCCRANKFNKLVLAQHLDDLAESFIMSAMYNGQVRTMKAKYMNDTNDVEILRPLVYVREEALKQFAYASRLPIINENCPACFEQPKERQRVKKMLFKEESLNPDMYNSFRRALLPLMDNDIYAPLHAIRARIDTQKKAKSNTTASTRQQSSSARQPHVDLDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WU87</accession>
    <name>A0A6G0WU87_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Calmodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_011610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000147">
        <property type="protein sequence ID" value="KAF0731062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WU87"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019593"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0731062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="513" mass="55281" checksum="F32C000CE7FC777D" modified="2020-08-12" version="1">MVWNGVKPSHASIAERRAMKRHAIPEHAYTGYVPGDTREPEAPKPVVGKIKRAIVGYGGHRHNKQDMIGTTFTHGLQVVPHPVELRKLKQPTKSKPDKAMSTSAYGNFDELSGYGQFAEPPRSKDSNQDDNDDVMEPTKRSGYGEFVNASGYGQFAKPPKAASGYGEFEKASGYGQFAAPPKANSGYGEFEKTSGYGQFAAPPAKAASGYGEFERASGYGQFAAPPKANSGYGEFEKASGYGQFAAPPKAHSGYGEFERASGYGQFAAPPEADSGYGGFERASGYGQFAEPPKAHSGYGEFEKASGYGQFAAPPPSISSEYGEFAKASGYGQFASPRHACDPSNDEQLSAPAIKRRVSRTNIQFAAKPNGAAVPPVRLGALHAPTKPSKPTASNEIHFDVFCCDENLRALYMRAIQHVGGRQSVRNLFARVTSVVHQKKGSTTEKRQRVKAVFQRVTSRDGTVGREQLKEALGQLSSLCTDQEILAMFSYFDRTCSGRVRASHFVGLFDAAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WW23</accession>
    <name>A0A6G0WW23_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_011047</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000140">
        <property type="protein sequence ID" value="KAF0731745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WW23"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004552"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="66"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0731745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="114" mass="13071" checksum="7613FC7A524333B1" modified="2020-08-12" version="1">MTMQDETGSMLLACSSGFQALARTPEKPARVEARQLSPSKEHKAPKQWYRCSICTKAYEREETLTEHMGRHKNQMKKRQQRLQESQDMEHAIKAPRTASATSVKATMARLKFFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WWT1</accession>
    <name>A0A6G0WWT1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">60S ribosomal export protein NMD3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_010906</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NMD3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000138">
        <property type="protein sequence ID" value="KAF0731955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WWT1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002639"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039768">
        <property type="entry name" value="Nmd3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007064">
        <property type="entry name" value="Nmd3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048899">
        <property type="entry name" value="NMD_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048898">
        <property type="entry name" value="OB_NMD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746:SF2">
        <property type="entry name" value="60S RIBOSOMAL EXPORT PROTEIN NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04981">
        <property type="entry name" value="NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21193">
        <property type="entry name" value="NMD_SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21192">
        <property type="entry name" value="OB_NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nmd3 N-terminal" evidence="9">
        <location>
            <begin position="5"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 SH3" evidence="11">
        <location>
            <begin position="243"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 OB-fold" evidence="10">
        <location>
            <begin position="305"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="398"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="424"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0731955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="473" mass="53810" checksum="254CCDC9F33A4549" modified="2020-08-12" version="1">MTILCCMCGVSIEPNMANMCAPCLSNEVDITEGISKELTLVQCRGCLRFQRTAGGKGSQLVFSECPLESLELMALCLKKIHGLNKDVKLIDASFIWTEPHSKRIKLKLTIRKEAVRNAFLQKSFVVTFVVENLKCADCTKQYRNETWKAVVQIRQKVNHKRTFYHLEQIILKHSAHERAVGMTAEKDGMDFFFGEKNSAERFTQFIGQHVPVRSKSARKLVSTDNHNNTANVKLTIVAEVAPICKDDIIVLDKRMAQLVGSSLVLVSRVTTQIHILDPLTARRAEITSEKYWKNPFEALDSASSMVDFIVLDVELLDRKASKDDDLMADVEVARVSDFGVNDTTFHVTTHLGRYLSAGDTVKGYDLGRCNFGTRQLYYLKDDLPDILLVRRVFPKKDAQDPKSKKRHARKSLGLARAKTRDADKEEEEYEAFMEEYEEEQEEIDGDEDEEETKEEAQVVEQEGVQVEETKRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WX01</accession>
    <name>A0A6G0WX01_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">WD repeat-containing protein 75 second beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_010740</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000137">
        <property type="protein sequence ID" value="KAF0732087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WX01"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002232"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000234">
        <property type="term" value="P:positive regulation of rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057644">
        <property type="entry name" value="Beta-prop_WDR75_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053826">
        <property type="entry name" value="WDR75"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23869">
        <property type="entry name" value="Beta-prop_WDR75_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23769">
        <property type="entry name" value="Beta-prop_WDR75_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="125"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="351"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="WD repeat-containing protein 75 second beta-propeller" evidence="10">
        <location>
            <begin position="455"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="831"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="841"/>
            <end position="853"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0732087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="886" mass="97509" checksum="3D7852702770C7CF" modified="2020-08-12" version="1">MTTPRVQKLSSGCTRAQRCLGITSSSDGKMVFEAQGDSVVVRSTKTGEVVNHLRADASPKNANASAIPEKLRMRIRNQHIRAHFETQYKNPHPDDDAATVAAHKASWIQRQVDKFAIPSDFHTHVTAIALHPTQNGQLLVATADNLLRVWDVAQGVSLETFTLEAPVVWMQASQVDPSLLVMVLNDTARVERNLAVLMTKEKSNKKKTDNGVKTKASKKLKWVLNLHGLETTHWKLLSFNLTKGTVEDQLLARKYLPFYGAQMQQRSLQSSHINAVALIASSTLFYVRIGVKNTGDSAPRPVDTIRLEHVRQFSCVTIHPTYDEVVTGDSMGQMQVWRQLDNGGGVQPSKLHWHAHRVACVAYSRDGTYVASGGEEFVLVLWHLESGRRQYMPRLSAALSSIETKADGSGYLVACQDNSILLFNPVTNSHEWQKGGLGRVGLSASKTLIARGLPVEPWSNSLTVQSKSLVGAIQFYNPLQDRVVGSLALTQRNQVSRTDDEAPIRTSASHVCFTARTMATVTTTLDECVLRFWTRKSDGSFAIHTDVDMPHGDHTITATAAHGGTVVTADDHGEFRLWNESKTNSAWTCRSVAHFRERPIGAIAFSEDGSLLAVAYDSLLTLWDPTTNVLKSVLSYPKTAILDVLFAPRTPHVIVRTTSGVYVWSLLTCTVSWFYTLPVACIAIAPTTGHLVMCVVTKPKTVDVVTHVIVFQDMATPLPISIERLPHIDAAAVTYYKNRVVVMDAMSHVYSVGDAADAEAEASRTLAPDTTSILQQMYGSLKTQAKDKSADWANADQDTSVQKSLFEAPAHVLPPLRSLYRSFLDTMLKARDDSTSRPAPSSSQATFTTTSSTDGVQPPTKKAKLERIEKPEDTYAALKKVFTKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WX14</accession>
    <name>A0A6G0WX14_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_010696</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000137">
        <property type="protein sequence ID" value="KAF0732043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WX14"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015196"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43102:SF2">
        <property type="entry name" value="GAF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43102">
        <property type="entry name" value="SLR1143 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="297"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="448"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0732043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="677" mass="74088" checksum="520F23E69B520277" modified="2020-08-12" version="1">MAARNPNEYGALGSGRSTRRGRTSPDTSRPTPPPPSPFRSLVDRGPANRSKWPWAFLHDLPSTKDSELLECMRDIVEIFLVECTARVNEPVDISLTTRGPLVSKYSQRRQLFTAHAVVDIAATFDEVKDLVMAPDDGFLHRIFNDNIQLSALSTIYAEEPSTPGPNYNGLQVYASCRLMKVLFCNPTQPKDLLFLDHVQSITSTAMLRVFKSVDNNNYPTLVHNQVVPRHTHIMGGYLIEALESTTSVRVTYYAEHAVYPKLFPSSLDTRTCLEKLGLGIPKWQQAVVSYPPRSRGATQESICRICAKSFNDNRRSSACTMCGAVICPECGGLDSSRGAKRQLPVCMMCLVQVRAEQNGSSALALAMAKPQIITKSNPPSSAPSSRRSPCQLCDRPSHATCAICGQPHCNQCADTTHANVVCYVCSTKPQDRHPILLLDPADRTLRLSDDHQRDTVSSSLPSSSIPRDTNPLSDEDLMTIQSLQQLQGPVGPQYRSSNGSLQSRLSTDGATSVAAATPSEVSDAWISRVCLDMESNDAYDALCEQAMVDMECTNAYVVLMYKGQFQLKGAAGTSYVPATIPGSCEFCTKTVATPQGPLIVPDAAANPIFQNSSRVKGKERVRFYYGLPVRTSSGQVIGTVAVVDTAPRMRVGRSHEQVMVRFAADVVDLVCRRIVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WYQ9</accession>
    <name>A0A6G0WYQ9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_010363</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000130">
        <property type="protein sequence ID" value="KAF0732655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WYQ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003521"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051345">
        <property type="entry name" value="Importin_beta-like_NTR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363:SF33">
        <property type="entry name" value="IMPORTIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363">
        <property type="entry name" value="TRANSPORTIN 3 AND IMPORTIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0732655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="942" mass="103361" checksum="6FF53800F088E4F1" modified="2020-08-12" version="1">MDTSKVVTFELFEKAIEALYGHDGPERQRLANEYLIHVWNHSKQSWEYGLQILKRRVPPGHADPTHTQYFCANMLYAKIRQEWFGLTEVEQRVIQSELELILQQIRLGQLCFAPLVLKRICMAMGVLYLAIDGGCAHCVNECVSKISSILDIQVALELLTCLCDEPDDSYLPPSRKDALVIEITDASTRVFSFLANIFDTNADSSVRIAGLACLKAWIKAAGFSLAKLFTTMPTVFRGILQAFQSPQTDSNAIKEVTLCALILSDALEVTEYPPSSEKEPALAALISTLLACETTIGFYLANDSNVAHALTTLVAAIGESELDWFVVGTAPEALRLTDLMLTLTSQPHRLTASLTFDFWLGIQDYPVASRHVIFQAAIFERLLHVLVRQCAQADLDDEDDGTTAFRQAAVDVVIAIYHLLQGNFLVHIGRMLSTAETKSVVEATMFVLTIIAPDLKLKIVDDKRSQELVQELCAKYVFGNTTFTTVPSVVRATSIFLGHLGSFVNARWTETGDDSLLVASLEYLGFALSVPLAAPVASKAINQLFAACSVLLVRKDLIVSSLLKAMESSRLDAESRDLILQGLVRVACLAPWGRLALDHLLAPTFTRMHRVPLDNSLLDDLATIGTVLRFLDAPSEEAGGSALTQHVLSSTWPHLHHVVVATADNATVAEALGDVFASVVQSMKANAASFAQTSEFSAIVTWLEGHVITTASALQAAITAVELFGPTGSPLMKRLIHTTTTAVMAYCQTVASPAHIPDLLRAFFELMQRSLLFCPSALFDEPSTFGAALSLAVGCMEALSHREALRAAVVYVNHIVSKRESTLALYQPIIDSSIAQQTPSLWKALVLLLTTTCPSTVLSTVTHVTFHLLTSYGAAMHSALFEALIVVESPLSEDEKRRVCATWIHMSTNFQERKFVAFVKDYAKVCRKEMPSEQLTDYFVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WYT4</accession>
    <name>A0A6G0WYT4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_010364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000130">
        <property type="protein sequence ID" value="KAF0732656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WYT4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003520"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0732656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="167" mass="19349" checksum="70A742087F22E88B" modified="2020-08-12" version="1">MRNAKYDYVEDAICDEAKEHAWDLTMWTTSTSGSSCTRTSLPLQPQQTQQREEDDAIARPKWTPLYHKPNAVSRSTTSSTRLSSEMMMQLEVARSKPRRQRDAKMHMYDDDHEDNGLDVRKEYERNDEAKYARPYDGHVAKHKRIGELLGMAKPVGPWNQRPQSVPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X122</accession>
    <name>A0A6G0X122_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Autophagy-related protein 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_009509</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Preautophagosomal structure membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ATG9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000121">
        <property type="protein sequence ID" value="KAF0733573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X122"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002972"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034497">
        <property type="term" value="P:protein localization to phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007241">
        <property type="entry name" value="Autophagy-rel_prot_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13038">
        <property type="entry name" value="APG9 AUTOPHAGY 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13038:SF10">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04109">
        <property type="entry name" value="ATG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8 10" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="391"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="474"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="514"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0733573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="756" mass="86337" checksum="17BDB05C27B7372B" modified="2020-08-12" version="1">MNDSLLDELEKAEADQHDLYDPNAAYRPLLEEDRANSMKNRSKSAEDAEALWAELHSQPPQQGAPHMSPSNIYKFHSVPASNIRPPANQYHKNMSPMSSGILHPPKQPANIDVRRHLNLPSLADIKHNWFLTSRGRHVPDDAGHVENVDAFLIALYNYYYHNGAACYMGKEIVQLFNLLFTVCASSFLLGCVKWNELRNCPTSEGGCKRPFSDFISWHFDGNLFSTVVLFYFMIFFVFWVTRVVAFASNARDVWDMHGFYVEKLRIDAHQIQTMTWDEVVDRLLVLLPQVLLPQANDRPSLTHHRSSYQLQVDPKALSTPLDIARRVMRKENYMIACMNSPLFQTELPSWVRLSSHVIFSRNMEFNLQMCVLDPMFSSTRPQSAEELKKRLTVAGIVNLLLIPFLLLFRTIQFFLVGAQEWSANRTMFLSSRRWSPLAMWTFREYNELPHVFDARVSKAYPLAEAYLGLFPTGLVSIIAGGVAFLAGSVMAILVFLSVVEESILLEIEVGSRQLIWYLTIAGWIFLLARSFQVSVRFTTGESYEEAMTKLAAETHHFPTVWRGQSHTFATRDALLALFPYKAVLFLEECASVLLAPYVLCVTLPENAHAIVRFLEEHTVTLPHVGAVCRFAEFDFKAYGGEPKMESSFMNFKRNHPTWTGPQEGEALVSQVSRFREQEMEKSLRLGDTLTPEAMSRTMMGESMFHSTAQLSLSHQLMQSQAIHMALGGPQSSEYYWLQKYHDRAVDHEEGKEEMDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X165</accession>
    <name>A0A6G0X165_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_009775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000122">
        <property type="protein sequence ID" value="KAF0733541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X165"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019235"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0733541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="203" mass="23602" checksum="CE9B845CD7DDF4C0" modified="2020-08-12" version="1">MYKCFMSDETYQWIPSKSHHRRENARLFEVLDRFLVYFKAESVPFMSLDDFKKGDVEFIKRVGSSPKMNCVENAVLTVAAFLNMQLKKWSGAGETKQFIDWFMKKGFRINRSIYEKNILKDIPNMSDPIQSLVHAFIKGGPGMYLVRTKDISLMGHFWSIRFQGGQTVVVSEKPARGIVAFKEIIAQVDYVRKCVPLDKKRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X1N8</accession>
    <name>A0A6G0X1N8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ADF-H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_009291</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin-binding proteins ADF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000119">
        <property type="protein sequence ID" value="KAF0733719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X1N8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013452"/>
    <dbReference type="OrthoDB" id="10249245at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11286">
        <property type="entry name" value="ADF_cofilin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017904">
        <property type="entry name" value="ADF/Cofilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11913">
        <property type="entry name" value="COFILIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="3">
        <location>
            <begin position="2"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0733719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="144" mass="16030" checksum="74DA2BEF2A1827C3" modified="2020-08-12" version="1">MSSGVGVHDDVVTKFNGFKLQSEGHRHRFVTFKIVGDEVTLDQLGDRDNTYEDFVNAISGPHTNNECRYGVFDLDCTTKDGRPTSKLVFISWSPDTTTIKNKMLYSSSKEALKRVLVGVGIFLNATDQSELEFASIQDGVSKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X1Z7</accession>
    <name>A0A6G0X1Z7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_009393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000119">
        <property type="protein sequence ID" value="KAF0733829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X1Z7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008930"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052981">
        <property type="entry name" value="Ingression_C2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47052">
        <property type="entry name" value="CONSERVED SERINE PROLINE-RICH PROTEIN (AFU_ORTHOLOGUE AFUA_2G01790)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47052:SF3">
        <property type="entry name" value="INGRESSION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0733829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="215" mass="22806" checksum="AB6C7E71363D0E42" modified="2020-08-12" version="1">MPELHLHAVGGRNLYDAQTFGKQDPFCKIQVGNQLQTTRVHDNGDRCPVWNEKFIFHVQNPQVDQITITIEDENTFVNGYIGSVCIPVNAFLHGQFVDQWFPVMRNTDHNGEINLRIQLMSVPGDMAGVPQPGYPAAQPGIVYSAAPSPPVYVVGAPVVYETPVVQEPPVAVSSVAVGAAAGLGVGLVGGALLGAALSDGGGDPCYYDSSSSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X2P8</accession>
    <name>A0A6G0X2P8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TATA element modulatory factor 1 TATA binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_009258</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000118">
        <property type="protein sequence ID" value="KAF0734089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X2P8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004339"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052602">
        <property type="entry name" value="Growth_transcription_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022091">
        <property type="entry name" value="TMF_TATA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46515:SF1">
        <property type="entry name" value="TATA ELEMENT MODULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46515">
        <property type="entry name" value="TATA ELEMENT MODULATORY FACTOR TMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12325">
        <property type="entry name" value="TMF_TATA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TATA element modulatory factor 1 TATA binding" evidence="3">
        <location>
            <begin position="660"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="175"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="291"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="371"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="503"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="668"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="100"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0734089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="765" mass="85593" checksum="48F8E4EB90221636" modified="2020-08-12" version="1">MSASWFTTKVNLSTIVSQGLEHVSKLKDDVEKQFDEAVSGKSVAKPPPPLPSLFNETPNPVVEPSPSPPLAIISEQNETTNEKQDEKDSPDDDASEHESSSTPPSEPSIDPSTPDTAMTPQDSPLNIEAQVVADSVDDTTVNPDDSTLQEQPLDDMNPSTDENIALLDVIKSIPPAEESKTATLPSDALESLPAETSHEESSSECTATEESQVVGPETPSSTPDLRENHLDVAALERELTGVQADLRKTQAMLRERENQLLASSNAMAKLHTEIEALRPNESTVYQLQVALADKEMQLKSLLEEGEALSKKQAAFESRLRAVRKEKTDVMEENKKLTAALETANAKWETARMHLVAAEDDAKVHVEVVKTLDATQARLATTEAALNAAKQALAAIEGQAKQLREENQRLEAQTHLAASEDRDVLEATIRDLQSKLSQIQMESAQQEETSRAELQAMKLRWQEAVTRMDQLTRSTGDATQPLLRQIHQLQQDQRAQELHRLALEEKMERRVQDALHDLETLQAKHDAVISQADEWRAQVTVLETEIENLRTAKSNEAAEIASLRKALDTETHRRQQLEQQVQVISQEKRHVAQLIQSSNEQHEAQVKQMKIENDHLVQQVNQLRWQLQESQKSAQVPAREIVALERKQSSSEVLVADSMVEWHQLQQKVRLRESEAALLKEQIQGLEDAKRNATEEVVRLTTRNATLESAASELETTKAALAAMEVKQQVLLELLGERDEQVEELETEFREFKQMYQTQIDALTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X3N1</accession>
    <name>A0A6G0X3N1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_008782</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000111">
        <property type="protein sequence ID" value="KAF0734540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X3N1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010656"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF34">
        <property type="entry name" value="PROTEIN ANGEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="3">
        <location>
            <begin position="88"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="456"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="506"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="546"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="695"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="927"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0734540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1082" mass="124052" checksum="BC961AE5CEAFAB60" modified="2020-08-12" version="1">MHNGDDHVEVTGESREPSTTEQRTSELNQPESQVGRGRRPSGRGKFARVPQRRAPTNVNVFSAIPNYDRAYTSYSETKENATSFRVVSFNVLADYLALSPTGSLAHSHPSQAWKYQWSFRRTRLLREILSWQAAIVCLQEDDHYGDYFEPELRKYGYVGANKQRTGVDTLDGCSIFVKADVFEIKRVVPLEYNQPGHAVLDRDNVALVLLLEHQASKEQIVVANTHILFNPRRGDVKLAQLQLLFETVESLECSKKILCGDFNLTPKSSLYEFISSGVLNGVSVATGEASGQYARGNHSYFHNDFHSKSDETVERHQGAGTAAYRFKPPTTPVRHGNSLGVQATHDLHLRSAYAQHPTDQTTGEPFATSYHDRFLGTVDYIWYGNVECTGVVEMPQMDFFQQIRALPTRDLGSDHLSLVADFALLRESHKMSLVDDDDLPSFSQDNNVVDEAEAPHELILDDPAETPPPLYTDKEPLKSAASSASSIYDYLDQVEMKSVQQLQLTASSAKSRQLPPLGRRTQVVWEPSPPPSSVKSSRSSQDNQYYAEIREKLVTLNIELQDKTQTIELLHAARKKDKAKAKEKAAQAEKEFKAALLAQKTQLEKDIEKQLDFAQTLVADKAELVKQCEAITAELKKSQERIQQTEESFQRQMKDAKERWTVQEKVKRDQWMVKKTEEIKKSTIKALEPDVQAIMTKCKENLDKARDAAADDKRKLIIAHEKEKDELLKRQREEYEKKLVEAWEKERSKLMYRLDAADAELQQQLNQQRRRLQDEAEKARNDLVLEMRALKLQHSRDLEDMRVVERQRIDHELTQLQKEKEELARRYDADAAALREKCKLEVDAMQSSIAASLRSEMEKEKAKWEAEMIKRRDEKIQMVIDKLHGETQKKVDAAEKRLAAQYELDTREFEKKLRAAGDIEAAWMEKNRELFDKCTKLEQQRDLMQAKCTEQAQALQAAQDNVARYSAALQEEREILSQERHNVARHVDAIRNESERERETLKSAVVSLEAKLDMMERKHAAYIADMRANHDDILEKLHARVRATVAKKDDMIETLREELHMTQVRVTKCEAIINQQREQLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X3S3</accession>
    <name>A0A6G0X3S3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_008758</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000111">
        <property type="protein sequence ID" value="KAF0734511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X3S3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018611"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0734511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="380" mass="41808" checksum="90DCA995662F00BF" modified="2020-08-12" version="1">MAATSLCGDSLVAMMSRETSKAYRAMKQFEKELTCANEGDCAAWLRSLLVLPHSSLGYNFMLLRRCIDGSFLDSDSSDGDDDDQDSLADWMLQGLVEQNDALLEISRQFSVNTTAFHESALFEWLQLVHALVLKTHDVFPLMVWSNVMLPLLGESSEIAQFNQVELLSTLVDVAGALEDKPDAPPFAALVSSCLFGPLPFPVAQAFSSDNTSNGVGYFIGHACLPYTQQWLRLLFHVLVIDPSVADSSWPFPALAPSCFRQSLLKIAAEEDDVLVDLAHVCLRFCSQQSPVQNATTSMATILRKECAPALIFADFCAAINDDHLVLIDLLSSDGKLSFQAAPCDFVCRNKCPGISCRYLSVYLFQLAHLRITVASSWPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X456</accession>
    <name>A0A6G0X456_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Saposin B-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_008689</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000107">
        <property type="protein sequence ID" value="KAF0734731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X456"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016155"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.225.10">
        <property type="entry name" value="Saposin-like"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008138">
        <property type="entry name" value="SapB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011001">
        <property type="entry name" value="Saposin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008139">
        <property type="entry name" value="SaposinB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051428">
        <property type="entry name" value="Sphingo_Act-Surfact_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11480">
        <property type="entry name" value="SAPOSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03489">
        <property type="entry name" value="SapB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00741">
        <property type="entry name" value="SapB"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47862">
        <property type="entry name" value="Saposin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50015">
        <property type="entry name" value="SAP_B"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026050052" description="Saposin B-type domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="4">
        <location>
            <begin position="133"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="4">
        <location>
            <begin position="422"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="4">
        <location>
            <begin position="524"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="4">
        <location>
            <begin position="948"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="4">
        <location>
            <begin position="1051"/>
            <end position="1130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0734731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1146" mass="125251" checksum="8B0B4B8A4A5B66BE" modified="2020-08-12" version="1">MMIYRSAALAACLWSQASSLSEDWFDDVMKQSFPHVQSVMSVVMVKPDPCEVAVKSIQTLHNDDDMFEEMFESFFPNPACQGQLLFSPADEEECMAIQSSPEVEEMVASGIDQPQLVCGWRKFWMEAKDSQGAFDSCELCERTVQMIENSFQQQELAIEIVDEALKLLCQYLPESTKCKTLVTNFDNIVKWLKEGLSPHNICQKVSMCTAHKLSLPASRFRPSIDNDDLCAICRDNAIAMQSLVGLPHGVQLYKGGLDSICALAPETATCRFMSTHFHKLAAHLKRGDSADSTCRAVHACHSTEVAVTGPTYLGCIYCEFVGQVVTSALHQGGNETLPYVRTDVAAMCSNLPASAQCDQMDEKFDEFAKLMAQGKTPEAGCEAINMCSPLSVPQTADSSTADLLAILDKLVFALDKKYDLTHYVACSTCEHTAYAIERVEKHHNGSLPTLKKAIKDLCHFLPPCTKCHDIVSKFDNLVGLIEKGTKAKPACVELGFCQPEVEVLRLSPMDAVENPVVAKAPTNGIVGCIFCQYTGEMISEVAKYSKDVVPLLKMGVETLCTRLPSEAKCSSVVDSFDALAADIEAGKSPLESCQDVKLCDAQNVLLMDNSLAVTSVHALETLMHSPKKDDVTCASCEAMARAIDAILKYNKNLIPVFKMGMEVLCERFHTSQCVNVMPQFDRLVELIESGKSFLDACDSAKLCGANALVSSKLHDLEGVALKRSNDDVTCEMCEAVSGSIFSLEKYNKQLIPVFKMGLEVLCDRLQTPQCIHVMPEFDHLVDLVENGKNFLEACDEAKLCGTKALNPLAVQKLNNLEKEVAGWMDRPATKSSDELSCMLCEYTGEVIDQVAQYDKDVVPFLKQGIESLCPRLPVQTQCEQVVTQFDTLAELIEAGTAAPDPCIKVQLCGKSSPTKELALPSSSVGYVQTQLDMFALKMRAITVTRPNDVLTCLLCEDTALLIRTIAQYDKDVVPLLKTGLATLCSQVPQLEAQCNAVVDKFDSLASLIEAGTDPSEACSKTKLCEIGKAATLALESKVADWVAYPESAVGSDEGCLFCQYASESIRTVMKLDKKQLPVVREAIGAMCSFLPPTVHCDDVNEHFEQLTKSLESGSSPLDACHGIALCDAPEPSAKMRIVIDELMATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X4C9</accession>
    <name>A0A6G0X4C9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ae201684_008639</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000106">
        <property type="protein sequence ID" value="KAF0734791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X4C9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001503"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005267">
        <property type="term" value="F:potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003929">
        <property type="entry name" value="K_chnl_BK_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047871">
        <property type="entry name" value="K_chnl_Slo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027:SF10">
        <property type="entry name" value="SLOWPOKE 2, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03493">
        <property type="entry name" value="BK_channel_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22614">
        <property type="entry name" value="Slo-like_RCK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="12">
        <location>
            <begin position="80"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="14">
        <location>
            <begin position="314"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium-activated potassium channel BK alpha subunit" evidence="13">
        <location>
            <begin position="459"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="14">
        <location>
            <begin position="712"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF22614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF0734791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="906" mass="101584" checksum="7A8DD7F41498BD8E" modified="2020-08-12" version="1">MTVLPAKTWSSRRGLAAGVSLRMKREKAFLSDRQKLTEESILSKILLGNEQWDLFHGIPKGYSLRTRVRIKLETSRTGYAWDILQTIVSLVACALCVVQSYMPDASYPQLDLVICGVFAADYILRFYCAENRYIFPFTFTAIIDVLAVAPTIYDRFIEPLAEIHGQKPTLAFVRFIRVLRVMKVIQMSRHSPTQLISAVQQQLISLGLLITSIVFVSACLFQLVENSYRDSIITADGRVVDESLTLGDCFYFILVTISTVGYGDVIPVTTFGKFVTCAMILMSLVMLPKEVNRLIELLSMQSPFRRTYNPHPANPHVLLLGYVSNATTLMDFINEFYHPDRIVGNGDGIATMNNIPCVIMAPMEPTEEVRALLLNPLLQNKVIYIKGSIFNEDDFRRVGGDMAQAAFLLTDKNSNDSTAEDANTVLRSLLLENANPLLQVFMQVIRPSYTEVLTHNHRHHVLCIDELKLNLMAKNCLCPGLSTLVCNLFRSSNIPDALPAAEWRREYMEGCTMEIYTTAAPFYLTDLPFTQAASILYDIFDGEVILVGVHQGDVTSRSFAADASCYKSRPTFLNSIKALSASFFAEEVHAPWSRSHPPSAAGHNDDKTRTRRTFVNPGANFVLKSHHTLYVLCESRNVAQLVSSSAYYNHWVDRGNTIDKSEPPLPQINNVHLANTKLVATRAPVCRSRKEVCIGAAVPLEDLDPFSSTATLRDHIIVVSDLVDVPIETFIKPLRLTHYTNGSQHFHPIVFVSTNEAAIDVAFASARHYDGVYLMHTSTESNEMYFRAGILEANCCVLLAEKSGQRVMDGESLDSRAIFRYLTVQKILEKHSQTMHVDFAVFVEMTASSTIKVLNTTLTKRIKHSVLSSNPKQGRGNLMQPRRAVPHVGVILESYELNHLKRFNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X4I8</accession>
    <name>A0A6G0X4I8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_008499</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000103">
        <property type="protein sequence ID" value="KAF0734835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X4I8"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0734835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="80" mass="8406" checksum="615F059C81CD8442" modified="2020-08-12" version="1">MFRQLGSVNLISKLSNIAMRLNPGCGVGLSVRLGRRRVVARTESISVDFQPIRAVFEVGGCGFVGCRQPLGGGEVVGVGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X4P7</accession>
    <name>A0A6G0X4P7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_008568</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000103">
        <property type="protein sequence ID" value="KAF0734906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X4P7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020322"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="354"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0734906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="570" mass="63303" checksum="5593B0E9FC15BF53" modified="2020-08-12" version="1">MMLLQCGGCKDSSESPRLDSSMSRLHPRRGSVNEEFGYQTLHTYATSSQSRCVDSPLAQSSQSSGVPDPYKSKTAALLWIESDESSMGHADGDVPNFQSFCPPHKWSAAFASPGDFTLKAAHVKRSHGTITYYLALIGLSIPTTSSGSSSPLAPTTQLPRSRTEGGFSPVSRKDKAQSVSIIPKTEAEITSFVHTMALRYPGHHVIALYSRKMQKARKLEARAQVVVEVLASILSITHVGLHRLIAVKEPVPQDLRVRIFLSLHLFRGTLPTGSNSCDGRLESQQSTSEANAIETRKPIPSEWLHPKQTPLPTRLAISSRKERRRSFRAVPCCTTYVSPMEWNKKAPETSGAFTVQITSIHTPTNTDSAASDVVQYIVTVLYVDPVNPSAHLTRTVLHRYADFWRLATHVHTKTKLDSHMHQLPPKTLFRSADPAFLEARAVGLQRFLDTLLCLSFKGMLDQKIDMAAEPQVRSFLELPPVQWNVVAEHPSKQDLDRFRALSNSSTASTRSISPLKTSDDEDEDDDDTDAEAGRISDERIFAEFESRVERPFQNRRSMSSQYYPVSRGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X5D0</accession>
    <name>A0A6G0X5D0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_008351</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000101">
        <property type="protein sequence ID" value="KAF0735140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X5D0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010336"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0735140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="395" mass="43752" checksum="063584C225A72D35" modified="2020-08-12" version="1">MSDFEETDDRSQGVAATIGAVALLGFGEACFRCRRPVPLGLACKYALFNMLPSVVWRSIDMPLLCKAAKLPLHEALEPSIVSETLRVTRYIVASYGALNEFLQWRQKKTPEALARVLRLTTSTSDLTPLSLQKHGSHLTPIKLDTDDALDSTQLNMQQWCLQPHDSSRDDLFLLEVDFSSITSAPQAKQTMRAVRQLIQPYRGSKAMTRRLEALVVVLSSPNTVEDIVAGGEWDICINTASVLSANLEDFVSSADPNAPVVIHTDSTELFNQVAQGLLQHNRIPVRYRESMPTVPSAVHVIAFSKESNAIERLHVLVDQDVPKSSICIISDVALSEPSIRVLHLAQLYDQVLQLVRGQLRSGMTADEIQDGLRRRYGPVNALTHGGFRHDKYSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X646</accession>
    <name>A0A6G0X646_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_008114</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000098">
        <property type="protein sequence ID" value="KAF0735425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X646"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005483"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045160">
        <property type="entry name" value="ATG16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19878">
        <property type="entry name" value="AUTOPHAGY PROTEIN 16-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19878:SF8">
        <property type="entry name" value="AUTOPHAGY-RELATED 16, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="177"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="263"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="320"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="347"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="406"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="436"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="72"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0735425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="468" mass="52076" checksum="9A9659C57F40BEB1" modified="2020-08-12" version="1">MQKERDHAGLRVMSERISERNRVETQAFSALITSYQQIMAQLQYISSQNQRMHVQSTNASPDKIVQMKDEQLMQLQRRIYEIEATGKEMEKEMHELRDELNRQRIRAELAEQEAEEFRRRVRDLEHQLIEKSKMMQELMLDASQSDNPSTSTATSAASHLPDTPDAMNLTLKDGKCIRAHATEVNSVCFNGSGKVVFTASSDGTVRAWDSFSCQAKADYRGLGMSQPLICVRVSEDGELVLGTGCDRICQVWRVGTGRIAHTLLGHKGKVYAAEFLLDQTNEVLTGGADRSIRVWDVASGRNLKTFSCRSTCNDLAVAVGGLFASAHQDGAVRFWDARTKNPVHEMPDLHADQITSVSFTKDGTKLLTNSRDNSLNLLDTRMFDKLSTFTAPSYVCGFNWSKATITPDGQFVAAGSSSGSVLIWDAATTKVWRENKDTHTGAVVGCMWSPNGQMLASCDKNGCLVLWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X6U9</accession>
    <name>A0A6G0X6U9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_007965</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000094">
        <property type="protein sequence ID" value="KAF0735648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X6U9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002792"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF18">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="19"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0735648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="331" mass="35536" checksum="03ECBF7222C1D8D4" modified="2020-08-12" version="1">MAAAYPAKMRALFLVERISSFDQPNLAACFEVREVDTPTPKYGEVLVKVECSPINPSNLSILKGEYSDSAKNALPSLIGTEGSGTRVGIFSNNQGVWAEYVAVNEFNCVTLPDDISFEGGSSCFVNPLTVVAFVEIAIERRVKAIVHTAGASALGKMLIKHAKEYDIEVIAVVRRADQAKSLQAIGAKYIVDTSVAEWKAELKTLASDLGATLGFDAVAGSLTGDILESMPNGSEVQVYGGLSNQASNGLSPRGLIFEKKKVSGFWLVEYMKVRGTLGVLSMVRKVSNGLEETFSTTISRGYALENAAQAIQDYTKNMSDNKVAFIPPQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X714</accession>
    <name>A0A6G0X714_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_007814</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M67A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000093">
        <property type="protein sequence ID" value="KAF0735809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X714"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002068"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005838">
        <property type="term" value="C:proteasome regulatory particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08062">
        <property type="entry name" value="MPN_RPN7_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000013">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033858">
        <property type="entry name" value="MPN_RPN7_8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF7">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="4">
        <location>
            <begin position="20"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="293"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0735809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="317" mass="35814" checksum="EA3DF8E897802EF6" modified="2020-08-12" version="1">MADDEITQAVVHVPGLPTEVVTHPLVLLSIVDHYNRVAKDTSKRVVGVLLGSVSKGKCDVTNSFAVPFDEDLRHPSIWYLDHDYLENMYGMFKKISANERIVGFYSTGPKIRTADLSLDELFRRYCPNPVLVICDVRPNVEGLPTTAYGSIEEVEEDGKAIKRTFKHIKSTIAAYEAEEVGVEHLLRDINDPSVSSLAGQVKHKMTALNGLKERVEEMRLYLQHVEEGKMPVNHQIVYNMQTIFNLLPNLNVEELVRAMFVKTNDMHLVIYLSSLIRCTIALHNLVNNKIKYKESEEEEQQQPKKEVKATSTPSAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X7D4</accession>
    <name>A0A6G0X7D4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sensor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_007872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000093">
        <property type="protein sequence ID" value="KAF0735870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X7D4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006947"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0735870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="33396" checksum="765EA69EFACFB9CB" modified="2020-08-12" version="1">MYNPVDDGVAIPMVPQATYVQPEPTYVPSPPLVASKLMPPARKKRCSCCWRVLFSPLWPQTYRLLLFHVGNLILAALAFATVVTLTVVGILVLPLCCCGLVVLRLLVFVVHFFARWDAYLYNFVASQGERIVVHIDVPRQGFYHVRGYRIATDSSRFSKQGFMAMFYFVGIKFPLSGLLSSAVLLLLIISIQLLATGVTGHDFFQGLHQEIMNHFHIGGASSIGFLVAGIGLLYLTIVFMHLFARILRLATKYFLCEYFATVGVVVRDDSSLLHPLLVEPNGELVPHDVVVTPLGTISQNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X8U5</accession>
    <name>A0A6G0X8U5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_007325</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X8U5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015213"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014867">
        <property type="entry name" value="Spore_coat_CotH_CotH2/3/7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08757">
        <property type="entry name" value="CotH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026067346" description="EGF-like domain-containing protein" evidence="3">
        <location>
            <begin position="26"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="617"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0736304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="659" mass="73015" checksum="3E85E691ECB012E2" modified="2020-08-12" version="1">MQRLVVSVVVAWTAILAAGVAPVAANHHRHHRHHRHHHDHHHGHDRDIEDTPANATLSTSDRATNPQCYLMPILLLQPTVPLPTSDCVQDPLPSPDCAKKTVATTLHVLHNKDDEWTCLQTDLANATTVSPRVRYRGDSSLRFNKHQLLLLFDEPTSLLGLPPDARWALHGPFIDGSLMRNHLAHWLYRNTGRYSPRTQHVALYMVNKPGGKPKYFGFYLLVETIGYGPQRVGLALNEPNCTDHSGGWAWQYNPITYGAYTPNILMDMYQGKFGMGSRPLLMYPPGESLSQAMRDSFVADTGFLPQLYRYLWHNMTSPKLLSTHLDIGSYVDYFLHTEWSLNQDAYSKSAFFFKDRASPIEAGPVWDLNLAYGLGSHATQTTTWLYKQQPAWMRLVCNFEFASIAIARWKALRSTVWSNESVTLFIDGTEGVLSRNLAKCSNWMSDKYSCASVSASNQGSYVAQVALLKASLISRAQWMDANIESLYSKLSGDICGSVGDLPEYNCAEDGNDGGCIVNPSAYYTRVPIPPIRQPSKVTPCPPAPPATTVDTYNAPSIDPCWLSVGSYVTAGYITLTCSGHGTCPSGPNASCICNNKATTPDCATAVSLDDMPKVHLLSLWFCGGILLVLGAGVGITWLRNKIRRRHYSPISLDLKYGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X9C2</accession>
    <name>A0A6G0X9C2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_007562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X9C2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006307"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0736552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="426" mass="46579" checksum="76898E150BB531CF" modified="2020-08-12" version="1">MLFESQMATAEKKPEEKPARRQYGEKFRPQQQPQQWKPEGQAKGQGPAAKHVHLARGCLKCGSDDHKVAQCPKYAPGEAQRLLTQRAKRPPVAANTPAAAPSGKPEGKKNVVGATINVSESKLEVLQEPRTVPCTVNGLDALALLGSDADQSVVSPALITRLSDAGALLAPVCKLESALELGGFMEDMKLSVDREVKLKLTFDTAEGRLVLTNLKCWVAAAPVHNGLGDVIVSRAVMARLGYSPRSLLETAHRAQKVYDLGHLGGQDTCLMAAIKILEDKKKPPVAPEEVALNVDEELSCFPQVGVDWSFDDDRAAVRAKLKEKVGECRVAGCDDSYAVELGKLLVKYEDVFRLKLGRDPPVKVEPLRVTLKADAKPVRCKARRYSKKQREFMAKHVEELQAAGLCYRNPRSKWCSAPLIVKKPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X9X8</accession>
    <name>A0A6G0X9X8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cysteine/serine-rich nuclear protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_006975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000087">
        <property type="protein sequence ID" value="KAF0736818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X9X8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001413"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031972">
        <property type="entry name" value="CSRNP_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16019">
        <property type="entry name" value="CSRNP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cysteine/serine-rich nuclear protein N-terminal" evidence="2">
        <location>
            <begin position="23"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0736818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="152" mass="17402" checksum="88AB9A161CAC4B7A" modified="2020-08-12" version="1">MAAAPSPLASSTSTSSLAEHESKRKRLEFTTATIYVFEIDHGGSALPAETGPPVGLAQRHTHLEHIDLKAHTKASRASRRVRKYNHHERMDLLKAANYSMKEIADFCFEAIDIRKSRLATLDEIEARRQERRRKRLQARRALLEDQDNRDTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XAJ3</accession>
    <name>A0A6G0XAJ3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Deacetylase sirtuin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_006820</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000085">
        <property type="protein sequence ID" value="KAF0737009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XAJ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005164"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01407">
        <property type="entry name" value="SIR2-fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF6">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0737009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="316" mass="34091" checksum="1C077FABAAD20C15" modified="2020-08-12" version="1">MMSKLSSIVQELRDGKIKHVVVFIGAGVSTASGIPDFRSPSGLYAQLQPELLTATPEEQALLRQYPTAVVTSDLFEQNAFPLLEACRPFLLGATEQAWKPTIAHAFFQLLHENGLLQRIYSQNVDGLHYQLGIPRDRVVDVHGTMAQVQCERCQTDGGYTFESFCGAVRAKIKNIHDKTGGPATSSPILCQTCGRASVKPAVVLFGGRLPPEFAIKSATDFPACDLLIVAGTSLTVYPAAGLVTQVRPGVPRLVVNLEPVGDDLGVDCRVDSNRDAFVQVDCDAGFLRLATELGWLEQLLALRSQLCAASQALLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XB03</accession>
    <name>A0A6G0XB03_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_006464</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XB03"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015819"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051052">
        <property type="entry name" value="Diverse_substrate_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942">
        <property type="entry name" value="METHYLTRANSF_11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942:SF4">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13905">
        <property type="entry name" value="Thioredoxin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thioredoxin-like fold" evidence="5">
        <location>
            <begin position="56"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase type 11" evidence="4">
        <location>
            <begin position="359"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0737291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="537" mass="60597" checksum="4A0168BAD3C31E92" modified="2020-08-12" version="1">MSLSAAVLVHWWVSLPIKCNVEEMMRILQFMPSSVQVASLLAPFFDTEGAKNRQSVLVLFFSASWCKPANDKTQSKLRELIQPKKIDIPCLVLSADLDQIQFNEHVEELTWAEIFSLTRRDELIQIYRHFGINAVPHVLVIDREMNVLSTDKLQVLLNLDREPSIAEKLESLLHPEPEGVENLAADDPMLHEMRKNANIRYDEGDFHGAASIFSEVLALSPQCARSNFNMAVILHTMGQTHLAVQYMLNVIEVDPNDATAHSVLRTVFFTPEPDLVLRGYEDIVKRHPDHVRATHSLAALRGDATTSEARYVRQVFDDLSDTFEEKLVQHLHYKVPWQLLDLVKSVTPLETSKQSWRVVDLGCGTGLCGRLFKPFVQHIVGVDLSPLMIEKSRATACYDALYADDLLPVLHALPDASMDLVLSADVWIYVGALELVFQACRRVMKPDGNLPSSKPSSPATSSSYLAFSIEEFHDTVSPDEPHLEYQLVHSGRFQHSRRYIERLANDYSFRVVAAESIVVRHESVEPIPGVLYVLEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XB08</accession>
    <name>A0A6G0XB08_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MoaB/Mog domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_006515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XB08"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000974"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00885">
        <property type="entry name" value="cinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050101">
        <property type="entry name" value="CinA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056596">
        <property type="entry name" value="FLAD1_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13939">
        <property type="entry name" value="NICOTINAMIDE-NUCLEOTIDE AMIDOHYDROLASE PNCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13939:SF0">
        <property type="entry name" value="NMN AMIDOHYDROLASE-LIKE PROTEIN YFAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24102">
        <property type="entry name" value="FLAD1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="Molybdenum cofactor biosynthesis proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoaB/Mog" evidence="1">
        <location>
            <begin position="11"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0737346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="264" mass="29044" checksum="B8CDB6F30B312533" modified="2020-08-12" version="1">MSSLAVPPKAAICVIGNEVLSGKTLDSNSNFIAKFLFSRGIDLVRISVIPDEMDVIVDTVRHFSDLVGSTGYVFTTGGIGPTHDDITYEGIANAFNVPLELHQPTKDALYNYLAANSRGHELNEDRLRMATFPKGCDVLTTSSWVPIVKMRNVYVLPGTPRLMKQMLESNVDHFKGIPIHQAIARTKQPEGTIAATLKAVANEFPSVLIGSYVNLKEDHLQYEERSYNVQVTLYSRVESDIHAALPKAVAAIEGWVVDEVSKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XB95</accession>
    <name>A0A6G0XB95_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_006457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XB95"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015813"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0737284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="584" mass="65341" checksum="0809F5AD5CA5409E" modified="2020-08-12" version="1">MEKQERDHDDELESKQVVNDSEAKRGGDSDDEDAAPDAPSPDAPSPDVIALRDGYNQTYIIQSSKTHLHDVLFRCGNWCYTGKVDLGDSEITLGDLPLVIPALQKQQGSLQFLCEWKQIPSTSPYAVPLETLYDAFDFIGAELGSRAIEKKLMKAAQENSWVDDDSPDGKNFFELETGGFDCFDGIDLVASKTFVRGLILLVIFYQRSFYVVLHEGDGEQPLLDVRFPDLSQHLQGVHLRHYQENFMNMKKLVLWQSMPADLVAKSPPKTFQMQVKDVSGVGYNQTFLIQRTRPLEGHPESKLREVLFRFGSWCYNGHVDLGPKLELSDIPIVIPMLRRQQSALTFMCEVTKMPATSLFTATMEFIASIIPAVQQELAASEEVLAHMARKGQDDIGRWLDDSSTECFFELTIDPTPVLKHVEAIACKVYTGPLVLIVLYFDNAFYVHIEDGKDEQPLLDTRFPDVTCQKHGFQVKTYRNGVAGFPLLRKLTLWKVKYGGDDEEDDARVPETVVAKEKAEKKSEAKGTSSSGGGSSPTRKVNMPHHIAPLKASANLKSKLQELGPLTDKGKAPWDETGRPLGLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XBB5</accession>
    <name>A0A6G0XBB5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_006475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XBB5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010603"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0737304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="145" mass="16017" checksum="A082F004CF835A8C" modified="2020-08-12" version="1">MSFLFFFRICNAKIKSQLGGGWIVSTKNTTFGFARSVAAVSRRCPETAPFPFVISTMMKKMNNQSNPRKRERGLSMSAKRTESECTMASSGYAVKQQRAPLTLTSSKPAGGAQYLLAKGPDGTRGFYSRSKKLNAKAHEFVPSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XCD7</accession>
    <name>A0A6G0XCD7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Calpain catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_006256</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000081">
        <property type="protein sequence ID" value="KAF0737762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XCD7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019746"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.380">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022682">
        <property type="entry name" value="Calpain_domain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022683">
        <property type="entry name" value="Calpain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036213">
        <property type="entry name" value="Calpain_III_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF379">
        <property type="entry name" value="CALPAIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01067">
        <property type="entry name" value="Calpain_III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00720">
        <property type="entry name" value="calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49758">
        <property type="entry name" value="Calpain large subunit, middle domain (domain III)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="8">
        <location>
            <begin position="27"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="477"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="478"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0737762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="894" mass="100553" checksum="08A491A1C4A99596" modified="2020-08-12" version="1">MQFEGAGITLERNVIAMLSECGEVPPMYEDPDFAAKAISLYQDPEKLPEYATSAKRAVDDGEIHWYRPGQVTADPDYFKCTFGCGTLREGTGLNDTWLLGVFAALALHPDNLIENLFVSPMHDFKTYGIYTCQFYKDCQWLEVVADTRLPYSQQLEDVNEPGTKGVARPGHWLYGSSVNKSEVFVPLLMKAYAKFHGNYEVLHNGSILEAFVDCTGGSVKMINMMLDESHKLIETGQLWYKLVKHVHYKSVITCQLKMASMSYNEVTGSGILKNHLYIIQHVKELGPLKFVKLKNVWQKGLWKGDWSNDDSKWEDNLQVEAALRSDPLCEFNRTKIDGTFWMIWEDFVQVFNEIYIVRNFPQTFNQYCVRGEWVGQAAAGPPLKQHPEASPPAPPTTTRKWFIAPESEPAWFLNPQYRLVVTEKTSVVISLLQRDFRVFGGDNFGINFVLLQVKKRSLHASKVWEFDQDAVVAEAHSLPQQQQQANGTDKTHHPEREVSKGNIILEPNEAYILVPYTDHVGVEMEFFLRVFSPKPVQIDALRPLNTVLLQGKWRVSEEGSATNAGGPLCHSLAAAENLHWCQNPQYLLRSMDDSGKPVDMKLVLKRTGYKATAKGRRDHQKDSNAQCIGLTIVRPDVQVDASPVVKKKPSEKANFLGETKHKAKEGGGNKALPSRKLLVKADEYCCLSDYANPQVASVMLQKIAPEWLDRGLLVVPSLGEGRIDGAYELEVHSDASLTLEELPNGLAQTIAGEWSDKKGTAGGSHLCPDWKKNPKVYLTLKSVRAAEVKIDLYRSEYEWRSKCKKDSVGSMMGFYLFQGTKLNRESSTVVVDGKTWTETDFVPLHHIAASLTLPPVFNESYVIMPATWEPNHSGRFLVAVTADSEFTLQTDDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XDA7</accession>
    <name>A0A6G0XDA7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_006166</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0738190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XDA7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011747"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243:SF11">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243">
        <property type="entry name" value="INNER MEMBRANE TRANSPORTER YGJI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0738190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="631" mass="69425" checksum="DC48BB4377A9EBA3" modified="2020-08-12" version="1">MLCVASWAFPGPGQAKDLHVPADELAAVQKELQEEESVLGEWYSTSITGNDVLSSCLYSAGIVASKAGKMAPFANILVAATMFLFRFIYVEVVSAIPLNGGSYNTMLNTTSKRWAAFVSALAIIAYLATGVVSAVSASDYLGRQVQGIDTVWTATGILTVFAVLNICGLSESAVVAFVIFVLHTLTLSVLVVASIVYAVQHPNIFWANMETPFPSLDIEGKLLAGNAVTALFFGFSSAMLGVTGFETAANFVEEQAPGIFRKILRNIWYLSTFFNFTLSVLNLCVLPMDVTIANNTVVLAMMASTTIGRWFQLWLSIDGFIVLAGSVLTSYVGITGLARRLAKDRVLPEIFLVENAWRHTNHYIVLVYYFVATSLVWILHGNVVMLSSIYSYAFLALLVLFSLSAMLFKLKRSQMPRETTAPWWACIVGMTMSCMGFWGILMGDPKVSTIFTAYLLCVSLLILLMLERVFVLRLVMVVMKGLSPSPSNDKSRIPLLQSPSGVLGGHAIVKAIKTINQPPIVFFSKHPDLQVLNKAVLYVRRNEHTENLRIIHVYPRGSLPPTNFHDLVAVLDCMYPKLRIDSIVVEGEFNPSTVHWISKAQNIPTNMMFIRQPDNMDAHKVSMLGVRVITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XDP1</accession>
    <name>A0A6G0XDP1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_006145</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0738168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XDP1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001225"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051724">
        <property type="term" value="F:NAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052465">
        <property type="entry name" value="Mito_NAD+_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46131">
        <property type="entry name" value="SD08549P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46131:SF1">
        <property type="entry name" value="SD08549P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="15"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="104"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="198"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0738168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="289" mass="32386" checksum="C65610A9323481D8" modified="2020-08-12" version="1">MGAATTDESKFMHRHSHVREFFCGGTAAAINIVLTFIPNKIMFRQQLYGTSTIDAWASIREDGWIRLYRGVGPPLLQAAVSKSIMFGLYTSYLDRLRENFGESIGGLDTSHFAAVLSGTSEAMLTPFERVQTLLQTTKFNAEFNSMSDVFVRINAVSFRENYRGLTAILMRNAPSNAIFFGMREHVREMLPATTTSSATVAVDFASGAMLGAFLSTLFFPLNVAKTRMQSVYGHHERYISVVEALKLTYHERGSSWARVYRGVHINFARSLVTWGIINSAYEKLMILTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XDT1</accession>
    <name>A0A6G0XDT1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_006183</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0738208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XDT1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003218"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="766"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0738208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="808" mass="90289" checksum="030FFA48BBC0460B" modified="2020-08-12" version="1">MIYLNVAEPDAIGETLSWLKEALTGDEIIPLPVPLSLDSLYGQIRQETPFHRSVEHLIHRDTSAIIEQLRRERRRRNTISQHRLECIKARREQLRLQVEQTRQNIEIQLSNMDRHVADVQANAFRRLQVLLFECIGEMKKAIARAEQRVIAQEACVDTTMSTCEVNHAWAIFLKRCEEEFNLTTFIDIPPFVLSKDASTFVPNDQFNSWASALKSLISKKLDSTARTENGSAVSVSRIMVLQTSKLPSGNKTRLILAPEATNSPNSSPRGMMTAQYQSFCRLLSEYTSLSKPTSRRRQKAKTQIFPDGFSCTTPLSSSTIRWLPHAAHGPLHVPVNGSIYYCLDEYKCRRGHKNVEATESLLRIASPNLHQNAAVASSDRLALQYASDMDVNVALDGIFQVQNVVKTDHVLQATLEAFPHMRPLHFAPANISHLIQSTTYHDLVMTFTEEHQANLTMRYPLETFGAESLTHFYVAIPTARTSNSSNHLLLACKLHPISSDAMRTLIATYVIRDPSITDTTSLFSLYRQSFGPAPSTAYCIVEHPAFILPPGSDVPPALVVQYSTRSSPSPRKDATAEPMDSTVSLLGSFCRWRSCLDMASMGQSLCANHTRLERHLKPEERMQIIGPVDNLDISAKTMVAPSVEIKRIKHSSSLLEELLQKQLGATLQAFLDKVVGQGCNAALVQAFHASRTSDRALGSDNSVEQEKNLLEQIWEMEQATTDEISALAALGVYPTVELGLLKQKEDATQTMAQAAERKLRLFRTRRQEEEAKKQVKKRHPLLQPSKSCPVVAKGLAGKLKKPSAPKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XGB9</accession>
    <name>A0A6G0XGB9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acyltransferase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_005090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000066">
        <property type="protein sequence ID" value="KAF0739163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XGB9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001058"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050879">
        <property type="entry name" value="Acyltransferase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043968">
        <property type="entry name" value="SGNH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028:SF53">
        <property type="entry name" value="ACYL_TRANSF_3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19040">
        <property type="entry name" value="SGNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="2">
        <location>
            <begin position="48"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH" evidence="3">
        <location>
            <begin position="818"/>
            <end position="1041"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0739163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1059" mass="119372" checksum="3498DCC75A177210" modified="2020-08-12" version="1">MADEEGSEFKSGVAVDEANEFLVAEVAVGPAVSLKQPRNLHAIPYRPDIDGLRMLAVVPVLLFHAYPERFPSGFIGVDIFFVISGYLISSILFKESAKRTFTYANFYSRRVRRIYPTLLLVLSATWWLGSLYLLSTKLQAMATTMFAGTMFSANIQVMLLERGYFDDDIKENPLLHLWSLGVEEQFYIFWPCLVALLTRLPVRSAIVAQCVVLAMSFGFNLALLGYNDSNKYSFYFPLCRFWQMGVGGLLAYMNHSRFSQEYTTLAPREETEEIQAKQSSFILGPSATSWFGLSWIVLAIACLDEQSAFPGFWALLPTLGAALLIHAGPTAWFNQRVLSNSWAVFIGKISYALYLWHWPLLVFAKLRYPNPDFRPKYMTPLMMLVLAFVFSLSSVYHVENVLRRHKSKWVVPSLLSGMLAMSVLSAVAVVSPDSFAYSQQALKRPSDSHLAPELLQMPSQVLQVEDPNVSRFQNLSVPSQKAIEMARLGWHPDVGLLPIPANHSLGDDSGFILNPGHEDKSLVVVFGDKHMEMLKPRFVQLAENTKPKDLPTIVFKSMSYAPLRLCTWWVEILQRKLREVRPRGVIYAINWLKYLHPGSLAMDQAHNKSECCTDYSDACLGQSREDVKLILSQFEDDISLMTMYGIKVFVNTISPEGPAYDPTTMSNRSLSVNRTAFRQDHAWLLEQIERTITAAKANVYDLSDNLCWEDECHVVDPNGVPVRTNSNLLTSTFAANYLSVVDHIIAEMSSSSDNWKLGEAPNTSRGPRIEEPTVSKIKDAWSCWWTDQGYSQLAHDSIYNTPPGQWGYGDRSLNLGQERLVIAVGDSHASQVKPRFLKLYNDHVAAKKASPFPSILFKSFNGVPFLSCSPTYEPILAMIKRVRPKVVLHSMNWPQFLQPGGKDSDEIVGGPQCCRSSYRDNCDYQRPKDIPALIKQLQADLTELTSLGIKVFVATLNPECKQFEPNHMLSGDDVGDIRPVYKSKFRQEHKELIDLVETAVAAANATLIDYADNYCWEDVCQVVDHYGRPIFKDSDHLTSTFVYRYLSVVDQVIDAAMAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XGT9</accession>
    <name>A0A6G0XGT9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Midasin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_004704</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the midasin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000063">
        <property type="protein sequence ID" value="KAF0739522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018818"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000142">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000582">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001368">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001384">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040848">
        <property type="entry name" value="AAA_lid_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012099">
        <property type="entry name" value="Midasin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041190">
        <property type="entry name" value="Midasin_AAA_lid_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103:SF2">
        <property type="entry name" value="MIDASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103">
        <property type="entry name" value="MIDASIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17865">
        <property type="entry name" value="AAA_lid_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17867">
        <property type="entry name" value="AAA_lid_7"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010340">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
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    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="11">
        <location>
            <begin position="5123"/>
            <end position="5266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="4441"/>
            <end position="4993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="4487"/>
            <end position="4507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="4515"/>
            <end position="4550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="4568"/>
            <end position="4594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="4602"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="4617"/>
            <end position="4627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="4635"/>
            <end position="4650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="4651"/>
            <end position="4662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="4663"/>
            <end position="4725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="4734"/>
            <end position="4744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="4777"/>
            <end position="4791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="4792"/>
            <end position="4810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="4811"/>
            <end position="4823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="4853"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
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        </location>
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        <location>
            <begin position="4972"/>
            <end position="4993"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017143"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR010340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0739522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="5331" mass="603289" checksum="C18E400C07151058" modified="2020-08-12" version="1">[encoded data, 5331 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XHB1</accession>
    <name>A0A6G0XHB1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_004702</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000063">
        <property type="protein sequence ID" value="KAF0739520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XHB1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018962"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
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    </dbReference>
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        <property type="entry name" value="GCP"/>
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        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="630"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="168"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0739520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="928" mass="106176" checksum="414E546F0289E9B7" modified="2020-08-12" version="1">MSIPHWTSKWREDIRRLVKVIQGHDVTPKKYVVDELQVDYYIRQLHTHSYLEPSTEKVKSTALGIVETLTFHHRDHQAIRIAEICFGSANATASRPLTIAPNIAKMLFELMHSPLSLHPDDMIEIEQLRHKRESYISQAIIEEQKVRTMARSLAGELRQLTLEDSWFGESNRNDEEEDIWSDDEPLPSPTLTKEKSNFQDELSLSSNESIPDIQAQESPPQPKLQEVIEETYQPNKPWLLNQGYSHVLRHLNVPLHFLEKSVRKEFEFVEDILVALLGVPTTTFGTEPCSLASAFWASMEYSRFKLTEQVQQQTVSHLTPACLYECLSQWSDVATTLSFNRASANYLGSFPSPCIQGFSYSVKTFIHEVDVIVSQQLHKMFAVKSTNPTLISLFQQLQPWLEKSTYLRQVIMQVIQPCENITVPVLGELVATLLTSLYLLLEESTLLGSEIEYSVLFELFNQSLDPYLNRLNDFLDGAPLPLDMGFCNDKSGLFESTLFDSLKFLPRAISPPCFFLQIQPMLLESHVYAKMGQVSNSRSFVLKPNYAEQILESTSSNFCDLTHMHPGLEKWGVEGLSRSTWSIRHSGSVLPPELSFRQFLQDKLIEPIKQRCNEIGRSTVTHLKTEWKVLDHMQAIRLFLLQQHPDSSNYFSEGLFQYILSPIPRSRWCDEYTLNALFLDALSKVPPNEPYLKHASHISIKTSIDQGSAVSNVLSLNAISFSYACPAPLNVLFRADVMENLSKLAVILLQLQGVERTLTGLKHTMRYRSCFPMIESAIHVHMIDLAGMIHFVKHVNIYFRNQTSHGHWEKLSQAIEKATFVSQINYELERWVQNMLENCFLLNKHYSIHTCLLQLLDHIINYVVQFEVALNGPQGDDTFLSLLAMAKKFKLALKNVITLLSTLVKIGSAPYLNELVLQLNFNEFYVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XHU3</accession>
    <name>A0A6G0XHU3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_004610</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000060">
        <property type="protein sequence ID" value="KAF0739836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XHU3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010307"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0229">DNA integration</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="11">
        <location>
            <begin position="247"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0739836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="357" mass="39084" checksum="AB40D85465E6CD09" modified="2020-08-12" version="1">MQGSTSASNGKAERMIRTLMDATRTMIFDCDLPPTFWSDAAKHAAYLRNRVPTRSNAGYLSPLEMLTGKAPKVNHLLRFGSDCTVHAPPANRGIITRGELGRVLGVNPTIKGYDIWVPRLGKVLTTRDVQNVTYTRASTRLSDVPESDLSFNRVQSKTTATKETPTSTKRVHFTRSTAGANASMATMTAEEPRAPRSPVVYDGDEGSYALIATITKDPKTVREALSGPNAAKWTAAMKAEIDSLIANGTWMLVPKPPGTNIVSNKWVFKIKYDSLGAVEKFKARLVARGFSQQYGVDFSETYSPVIKQAAVRFIFIVATLYGGIVEHVDVPQAYVRTNIDTPIHMEVPAMVDGDPET</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XII8</accession>
    <name>A0A6G0XII8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="10">2.7.8.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_004391</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12593"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60110"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the CDP-alcohol phosphatidyltransferase class-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.5" evidence="10"/>
    <dbReference type="EMBL" id="VJMJ01000054">
        <property type="protein sequence ID" value="KAF0740156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XII8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003788"/>
    <dbReference type="UniPathway" id="UPA00084">
        <property type="reaction ID" value="UER00503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09135">
        <property type="entry name" value="PLDc_PGS1_euk_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09137">
        <property type="entry name" value="PLDc_PGS1_euk_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016270">
        <property type="entry name" value="PGS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586:SF1">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000850">
        <property type="entry name" value="Phospholipase_D_PSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="11">
        <location>
            <begin position="136"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0740156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="448" mass="50628" checksum="2749AACE3B007AE4" modified="2020-08-12" version="1">MTTIGDVIDDLRESTPSFPLNPNDIKVLNSPTDFYNQLLDNIRHATKKISISSLYIGNDALCRKLVETLIEACSANSQLQVSIVLDFSRGQRGGSTSSVVMLRELLSRFPNNVSLHLYRVPQLDRWGFLPPPFDETIGVSHTKIYLCDDTLVMSGANLSGDYFTQRQDRYMQLHNADLAGFYHTFVQIVTDHAYRVEVTEANGVANTSLVNPKGTHAQFKSALLSLQDYQPTTPRWLTSTIAIPTIQFSPLDISHDEETLTHVLHRLPASSHIDIASGYLNFPPFLTRLLAERTLSLDVLTAAPSANGFFNGNGIKGALPMAYSLIESEFYDRFPATQLCLREYNRENWTFHAKGMWIKHHDEMLTIVGSSNFGQRSYGRDLESQVFLYTTDANLQATFKDEYHQLTQDSESVTSALWRRPDRQLNGLLSWKTGHWIRPAMRAVKSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XIV4</accession>
    <name>A0A6G0XIV4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin-dependent kinases regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_004223</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the CKS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000053">
        <property type="protein sequence ID" value="KAF0740218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XIV4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016787"/>
    <dbReference type="OrthoDB" id="440676at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.170.10:FF:000001">
        <property type="entry name" value="Cyclin-dependent kinases regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.170.10">
        <property type="entry name" value="Cyclin-dependent kinase, regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000789">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036858">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23415">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01111">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00296">
        <property type="entry name" value="CYCLINKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01084">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55637">
        <property type="entry name" value="Cell cycle regulatory proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00945">
        <property type="entry name" value="CKS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 4" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU311113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0740218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="105" mass="12483" checksum="CE9555777AAA38B2" modified="2020-08-12" version="1">MTHDIAARIEYSEKYVDDTHEYRHVILPKEMQRSLPDRLLTESEWRQLGVQQSRGWVHYAIHKPEPHILLFRRPLGTDPTTGRVNSAMEREAKEKYAQEMGQIRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XIZ6</accession>
    <name>A0A6G0XIZ6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_004381</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000054">
        <property type="protein sequence ID" value="KAF0740143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XIZ6"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0740143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="94" mass="10696" checksum="A4D1DE6AD810635C" modified="2020-08-12" version="1">MMWFQTSHENTILLMSLMHRPLFLRALCQVSTWFWFALTALPKLQSTSTHWSAVSLSISCTHSFSVSSHHSILTTDLTVAIPPPNLIRYASRAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJ10</accession>
    <name>A0A6G0XJ10_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Purple acid phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_004372</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="2"/>
    <dbReference type="EMBL" id="VJMJ01000054">
        <property type="protein sequence ID" value="KAF0740134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJ10"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003177"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.380">
        <property type="entry name" value="Purple acid phosphatase-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039331">
        <property type="entry name" value="PAPs-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015914">
        <property type="entry name" value="PAPs_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953">
        <property type="entry name" value="ACID PHOSPHATASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953:SF153">
        <property type="entry name" value="PURPLE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16656">
        <property type="entry name" value="Pur_ac_phosph_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49363">
        <property type="entry name" value="Purple acid phosphatase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026375037" description="Purple acid phosphatase" evidence="2">
        <location>
            <begin position="17"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase N-terminal" evidence="4">
        <location>
            <begin position="21"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="3">
        <location>
            <begin position="132"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0740134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="411" mass="45215" checksum="295364388BE4F8D1" modified="2020-08-12" version="1">MFAPSVLALLASVAAAGMIPQVHLGLTNVALNCPAGVSVNFATATQDPVTVTYGVAGSATTATANTTAFNYTVKTYTSPFLHSVNLCDLKPATEYKYTVGDFSASFVSPPAASADPTVIGLVGDADLDPDSFNEMIQPVQNLTTQAIVIVGDYSYANGNHKIWDDWYNLQQPVFSKLPNVGINGNHETIPCGDALRTYYSLNFGLVHLVFLDDYVGNTLTVGSDAWLAERQAQLDWFVADLDKVDRSKTPYVTVFKHNPFYNMYTDHTCQYADKIFEIPDKEACWRGNYTKATNEPQCGLQAKLEEAYAKYKVDVVFSGHVHGYERSEYIYQNKVNKEKGSIYVTTGAGGRGHAGARIANVPSWNVYAEPAKFGASRIIATREKMQVNWFMVENATQPADYFEVRARRDAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJC4</accession>
    <name>A0A6G0XJC4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_004261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000053">
        <property type="protein sequence ID" value="KAF0740260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJC4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016749"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="465"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="515"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="669"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0740260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="692" mass="78643" checksum="E5854CF71F85148A" modified="2020-08-12" version="1">MTQVLDRVKAAVLVVPKEVTWHAALTEILQANEEPRHDVVDMSVAARWAQERAFVQKQFEKCLEQVSMDPNLLFFNEPYETQYVSFMNAVNRSRVRLCFSVGAAASAILFWYEARYLELYDADKNDKLTLAQEHTLYWLSFGLIVPTFAFGFALSFLPVGKTRLESLASSVYMIVAMAFITKKCVQEAKGPIYPLVILLIPLFNVTRTRFAITCVVGWFIVLVFFIVNLSAGPDPTSSTVFTTLNYSMSVVAGMVSSYQKEILKRRNFTLGLNFSGAPSDASSRIHNPYYAKELLCHRWSQSFKHKDVERRFFRYWYLLDRHPYENPNAGILHMDVYVSLRYPLAGVCLNQVVLLLQDVINLYKTPTQYIALGFRVGCIMPAYMFLFSAIYFMSRTYAKEWLAANQAPPPQAADDAAKRTTDSISITTVVVKSKDAMKNQAKKAANKVKDGLVETQKGYSRTIQALTGMVLLFHVYLTGTLVYVIARNIGVKDVYFMGFLNTMMAAHRSSFRPRFMLSATVTLVACIGFLVGTRTVLPRRTLIEYSCYITVVQILGMIVSYEEENLRRSFFIKKSLRSLEFKAWLSSLVKIQVWIRKRMIKRALEAKARIRALERVQTNPSAANRKSILDRPLEVVDIHKNLRDLQTHLNKDNKVVTSASAKLSQASRYGVYSTCVSVLIAIGQVSFFLAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJR7</accession>
    <name>A0A6G0XJR7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_004164</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000052">
        <property type="protein sequence ID" value="KAF0740429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJR7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015905"/>
    <dbReference type="OrthoDB" id="47374at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000006">
        <property type="entry name" value="Putative n-alpha-acetyltransferase 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051556">
        <property type="entry name" value="N-term/lysine_N-AcTrnsfr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919:SF8">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="11"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0740429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="163" mass="18519" checksum="B7FACD4913FEF8D0" modified="2020-08-12" version="1">MDASGRKALSVRFGAITAQNVGVLRVLNQKIFPVRYNDGFYSDILSMPRELTKFGIVEDIIVSAICCRVETMPGGVERVYIMTLGVLEPYRRYKLGGALLQSVLDYCEKSHMDHIYLHVQTSNAEAIKFYATYGFEITQTIHNYYRNITPPDCYILARSFGTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XK79</accession>
    <name>A0A6G0XK79_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_003969</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000048">
        <property type="protein sequence ID" value="KAF0740592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XK79"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010241"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161270">
        <property type="entry name" value="PspA lactotransferrin-binding region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="44"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="229"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0740592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="240" mass="27378" checksum="397BCCDEA9B4E833" modified="2020-08-12" version="1">MGPRMSEAQRHFRIYRFLKMQYQDMQPIDMDRLFWMAITHQGVVKQQAERINEAMDNLERCKQDLEAAHSKIHEQAQDIVVMADCITDLNDRQQTRVQQTDLEMTQLREQVSTLTSELRVLKTNMTESDMAANRDKRQVSALTAELSVAKSLVAAKEMETSQLHDDLAAVTAELSALKLELLEASNSHKTFDDKTLALQDNKTLVLQDNKTLVLQDDKTLVPQDNSILDPKDDQVPHTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XKE5</accession>
    <name>A0A6G0XKE5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cytidyltransferase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_003897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000045">
        <property type="protein sequence ID" value="KAF0740766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XKE5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011827"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051182">
        <property type="entry name" value="Euk_NMN_adenylyltrnsfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039:SF0">
        <property type="entry name" value="NICOTINAMIDE-NUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="1">
        <location>
            <begin position="273"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0740766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="522" mass="58793" checksum="52873DC56747FBBE" modified="2020-08-12" version="1">MKRALVGRQDESTYDRRPHLVASLEDQCLEYTPRTVAKQKNELQALRERVLALENLLASRDDDIDSIYKNPVGSTQLPPLARSPTKGLVQNASLTKLPTVKLGFELERTATAPASLALPVQAVELPDVSTSEKEIPPTTSEPPPAHVISTKFIADQDGSLIVAVSKRSNLYRILQQISNRVALTDDQIFRLKKMVDAEFGDVISVLEAVEHEEDVNVVQAKMADLIQTGSPSKFAIQLSPPKFKMADVPYPLTKIAQNLATMTTHQEVVVLVASGAYNPVHMLHIRAFYVARQHIEANYKFAVVGGIISPCHDTYVRTKNRRKPREMIPNAHRLAMLEAATASSSWIEVDKWEITRRRVLDYLSTLTHVREICEAQFPQFKFRVLYVCGVNTVVKLSHTALRDEGFGCIAVCRPNQTEMLYKHLGAKWTKTAIVVEDVGVLSCELERATSFRVRQALIEGENCAQMVGKQVFDYMQRHHVGEKIAGRERWTSEDRLWRLQDLPYVEYTETEMMQSSQSSPNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XME6</accession>
    <name>A0A6G0XME6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_003245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000036">
        <property type="protein sequence ID" value="KAF0741564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XME6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006128"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0741564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="308" mass="33779" checksum="BC7B7E8C9F78FE04" modified="2020-08-12" version="1">MNRMHPAFFRCPKERTLCGLRVRQQQDLDATQHHEHDVLCETSNKLINESKRWRDSGHPFPGNHTGGDHPFPGNHIHDDKPFPGNHSNGDHPFPTRALEERPIPGNHSHGGHPFPGNHTGGDHPFPGNHTGGDRPFPGNHTHDGKPGNETHGDHPFPTRALEDRPFPGNHSHDDHPFPGNHTGGDRPFPGNHTGGDRPFPGNHTGDHPFPGNHTHDGKPGNETHGDHPFPTRALEDHPFPGNHSHDDHPFPGNHTGGDHPFPGNHTGDHPFPGDKPDHRGNETKIPPCHDGNNSHVPHVTPSPSPSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XMG1</accession>
    <name>A0A6G0XMG1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dolichyl-P-Man:Man5GlcNAc2-PP-dolichol alpha-1,3-mannosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.258</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_003514</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29527"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="Rhea" id="RHEA-COMP:19516"/>
            <dbReference type="Rhea" id="RHEA-COMP:19517"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:132515"/>
            <dbReference type="ChEBI" id="CHEBI:132516"/>
            <dbReference type="EC" id="2.4.1.258"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:29528"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.258" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000037">
        <property type="protein sequence ID" value="KAF0741409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XMG1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015742"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052925">
        <property type="term" value="F:dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007873">
        <property type="entry name" value="Glycosyltransferase_ALG3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12646:SF0">
        <property type="entry name" value="DOL-P-MAN:MAN(5)GLCNAC(2)-PP-DOL ALPHA-1,3-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12646">
        <property type="entry name" value="NOT56 - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05208">
        <property type="entry name" value="ALG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0741409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="556" mass="64050" checksum="25D66800253C3F16" modified="2020-08-12" version="1">MNKTKATNLKSEKRSTRIDKDVKKVSNFSKLLALAYDVLWSYRYFHLIAGFLLVFEFVFGIFVIQKIPYTEIDWKAYMQQVTQFKDGERDYLKIRGDTGPLVYPAGHVYVYSILHAVTNNGENIRLAQYIFLGFYLITLATIFAIFYRARVAPPWTAILVCTSKRFHSIYMLRLFNDGFAMMILFLSIYLFCRQQWRLGCLMYSFAVSIKMNCLLFAPALFFLLLQSSGVLRTIGYLFICASLQVALALPFLKTYWWSYLSKAFELNRVFTYAWTVNWKCISEGLFVSKTWALALLGGHIIILIVFLHKYFFSGPQGISIRTLLYKPFQLQERVPIRAERIVTSMFVVNFIGVCFARSLHYQFYAWYFPTLPYMLWKTNLPMLFKAKILIICEYAFSTYPATDISSTVLHLSHFMLLASLYTAGDDGKYQAYLDAESRQALIHFLNEECFDVARQFAMYYGSVTEDLAEGASVVSIDEQEVVLRLPKMNFTLAIGFGSSAPVTSEGYARRVLSGMSKEAEYGLSRGVNLGQAMKEQMNASNGNDDDELHVRLRRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XMM6</accession>
    <name>A0A6G0XMM6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="7">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_003311</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="7">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="7"/>
    <dbReference type="EMBL" id="VJMJ01000036">
        <property type="protein sequence ID" value="KAF0741635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XMM6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011105"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17949">
        <property type="entry name" value="DEADc_DDX31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="228"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="442"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="685"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="687"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="706"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0741635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="738" mass="81173" checksum="BD302A490A3E4548" modified="2020-08-12" version="1">MDGFSLNIAVSGSTSARPAKKKINKFRQNKNKHKKSNGATPSQSAARNKPAAPRTAEKDQAKVINQDEKVTTIAQPAKETLKEEDPSPKEAPKNAAPAVKTLSKPKDTSKEELVPSKEPTKPKALAPKVDSKPVEDGLKIKSAADKGTRRNPNKEAYTAETYLRPTIDMSKVVVHTAPVASKESTDIFASTTFEAMKLHPHLVSILTKEKDAGGFGFAKPTRVQVQSVPAIICGGDVLLKSETGSGKTLSYCLPLVHRLMAREPRVNRSEGCLAMILAPTRELCTQIQETLERLLKVAVYIVAGSVVGGEKKMAEKARLRKGLSILVATPGRLLDHLTNTHAFTYTRLQFLVLDEADRLLDLGFEKSIAQILDCLTAKQDDDVKRQTILVSATINAGVERLAALSLTDSTFIDADNSKGATTTFATPDQLVQHFMIIPAKQRLCALAAFVRSECKRNKRAKIVVFLSTCDAVDFVTSLFQKCTWPQSTAMFGPSVFRLHGNVVQQERTSTFQAFCKATAGVLFCTDVAARGLNLPTVQWIVQYDPPTETRDYVHRVGRTARSGAVGNSLLFLLPSEAAYCDHLQSLGLNVTALSLESTLARSAFKGEFKASSKKAVHEVVVHELQYLFEQTVLANAELFDVACQAFQSFVRSYATHSSETRQYFHVRSLHFGHVAKSFALREPPASNKVTKASQQAKGGSLKKRKERQDIDDSIEKKKQKKVIQEKRKYNHHVSEFAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XN78</accession>
    <name>A0A6G0XN78_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_003110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000034">
        <property type="protein sequence ID" value="KAF0741924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XN78"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000908"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="1">
        <location>
            <begin position="7"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0741924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="102" mass="11158" checksum="C8E9DF3CB7DD7189" modified="2020-08-12" version="1">MATAASSAYKTAHRHYLQYLKAPLPGVSITPVQADKYHVNTTLLEGPYEGITVHWELSIPDTYPYTPPLGGMAPGYAFNEVHHNHVIDDFGICCDVLGNDAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XP09</accession>
    <name>A0A6G0XP09_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_002822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000030">
        <property type="protein sequence ID" value="KAF0742153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XP09"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002302"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="266"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0742153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="389" mass="44105" checksum="F2B9B941FD02DC88" modified="2020-08-12" version="1">MQPVDMDYDDDDEEEMESQPTVQRRRFFKSGLSTYEEFYSRNETGRRLGRYSLHVKLNTERPTITLLLSNQHVDSAMPCEDDENEVATMPKRRQRCSSDPEVMDATGSFKGRSHSDDIFARASSFPEVVRPKAITTERFSFFRHRSLPRTSSWQQDSSLSESVPVVEASVVSADSVRPSFPLHHSESLEDLDTFPVIKDDLKPFDQTSPTHETSPSGGRESLLPRDSSFSADPSYQPVAIRSSVSNNVNVVKFVSGFKNTKTQRGSFRSSLDSRPSLDSVRKSARNKKQSFMSQQEQGLNKRLRDARNRIPLEFRDELAHLLEKPYVPKPKTTSKRVQFASSNDVFVFESPDDDDDDGATPQVVDDIVMLTDGDAEKVYIVELDEPIIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XQT8</accession>
    <name>A0A6G0XQT8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_002381</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000025">
        <property type="protein sequence ID" value="KAF0742680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XQT8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003832"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037176">
        <property type="entry name" value="Osmotin/thaumatin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001938">
        <property type="entry name" value="Thaumatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31737">
        <property type="entry name" value="PROTEIN TOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31737:SF2">
        <property type="entry name" value="PROTEIN TOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14295">
        <property type="entry name" value="PAN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49870">
        <property type="entry name" value="Osmotin, thaumatin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51367">
        <property type="entry name" value="THAUMATIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026018413" description="Apple domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="2">
        <location>
            <begin position="27"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0742680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="252" mass="27427" checksum="E70DD6C6EF5FD0BE" modified="2020-08-12" version="1">MRVQNVFGLLLSLAAWAHDCSDVQANTDYYGNDIATTVRGSPSDCCADCMAKPNCVVTVWYDGTCYLKNKVGTRSTLSGAHAIFPTRTPASLAPAPDTKASSPSFKFVNQCSYQIQLYKVDTLVCTLNGGKSCTQSLNANEHTMFRHKKIAETTLVEVTKSDKLWFDVSVVPPGCGNGKSHDACLRTNGGRSGFNIPVSVVPSKYNNNPAKGNCHSITCRQDNCPEAFTFPSDNLKMRDCPLDEMLVVTYCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XQW8</accession>
    <name>A0A6G0XQW8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-reducing end alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="4">3.2.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_002393</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 62 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="4"/>
    <dbReference type="EMBL" id="VJMJ01000025">
        <property type="protein sequence ID" value="KAF0742692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XQW8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017435"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08987">
        <property type="entry name" value="GH62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005193">
        <property type="entry name" value="GH62_arabinosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40631:SF2">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40631">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE AXHA-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03664">
        <property type="entry name" value="Glyco_hydro_62"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026241706" description="non-reducing end alpha-L-arabinofuranosidase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0742692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="328" mass="35275" checksum="28AD4E962278A462" modified="2020-08-12" version="1">MKLSLLTVATTLLVATLSNALNASVSVAQAELPSSFKWTSTGPIISAKNDGKGIKAIKDPSIVQVGDTYHVFASTASASGYNLVYLNFKDPSQAQQATFHYLDQTPIGRGYRAAPEVFYFAPQKLCNPAGWSAPKNFYSGMPAIIKNNIGNGNWVDMFVICDSANCHLFSSDDNGHLYRSQTSLANFPNGMSEPVIALQDANKNNLFEASAVYKTGNQYLLIVEAAGSNGRYFRSWTASSLSGAWTPLAASEANPFARSNNIAFPGGAWTTSISHGELIRTQTDQTISVDLCKPLRFLYQGLNPKATGAYDALPWQLGLLTQTNSAGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XR40</accession>
    <name>A0A6G0XR40_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_002074</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000022">
        <property type="protein sequence ID" value="KAF0743013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XR40"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0743013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="98" mass="11656" checksum="93D2DE21F5A9B1A7" modified="2020-08-12" version="1">MSFNCHSARRNVNHVSRRSAIILHFTNKPRLWSKFTFRSEPSSLQRRLGRSSIFQCPLSVEWTRRWTRAKTFMNMHAALGTRTQPSLTRLEEQVPWIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XS38</accession>
    <name>A0A6G0XS38_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histidine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_001968</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tRNA(His) + L-histidine + ATP = L-histidyl-tRNA(His) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PAL/histidase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000019">
        <property type="protein sequence ID" value="KAF0743279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XS38"/>
    <dbReference type="SMR" id="A0A6G0XS38"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013989"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00859">
        <property type="entry name" value="HisRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000061">
        <property type="entry name" value="Histidine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000012">
        <property type="entry name" value="Histidine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00127">
        <property type="entry name" value="His_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001106">
        <property type="entry name" value="Aromatic_Lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033656">
        <property type="entry name" value="HisRS_anticodon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476:SF7">
        <property type="entry name" value="HISTIDINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476">
        <property type="entry name" value="HISTIDYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00221">
        <property type="entry name" value="Lyase_aromatic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="12">
        <location>
            <begin position="474"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="365"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0743279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="932" mass="100907" checksum="95F4461A653F791C" modified="2020-08-12" version="1">MANRVNVGSKKLSLEEFSSVVFVGAKVTVEPLGVEELHTDVASRILSIPGAPSAIADPLPKDLGRAILLGRLNYIAKHAGCRSSAMVQTADFLAALLNADLVPFFPAPSTHLVEVDAAALVLLEALKGHGQAFHGSATVSLAEGLAAENITLPAPLTSIEEATLIQGAVSLQAVVTSIVCGAKGIAPIADAVAALTCEALKASSFPFQEAHDVDRPHRGMITVAANLRVMLDNSKFATANDKADPVALRCIPQYHGPARDSIAAAAKSIEADLNTAESVLGLTSFHPELLKQLLHSIHGAVESYWEGSRSRVALSKPVEAPKHEGFGPVQTFAFVQATQKQLVEELNIAEGLITKDSKKDDKAGASEVKDDAKAAEIAAKQAAAKAKEDAELAAMSEAQRAKVLAKRQAKLEKELEKAAKKAAKNSLTVGVGSSEFRTYVQKDLSLNPFDFRVQGTVAFLEEMFARLGAMAGGQKRRPKVAKGAQDFTPPQMHLRERIIHKIRSVFKRHGGVEIETPVFELKETLTGKYGEDTKLIYDLADQGGELLALRYDLTVPFARYMALHNPGKMKRFAIARVYRRDNPQPARGRFREFYQCDFDIAGSYPTMLADAEAITIAIEVLQQFPELGPFKIKLSHRKLLDAILELCGVPADKLRTTCSAIDKLDKETWENVRSEMVDEKDIPPEVADRIQGFVTQVGSPKALHAQLLAEKRFGDHPAAAEAMKELALLWSYLEAMGVLDYVSFDLSLARGLDYYTGLIYEYVLTGSDAAQVGSIAAGGRYDNLVGMFSATNAHIPCIGVSLGIERIFGMLQKHAENHGDGLKAPVAQVLVAQTSPGLLVPRLEVCRTLWGAHIAAEVLPSENENPKFIKQLQYALDMGIPFVVVLGEDERANKQVKVKVLAANEEITIAEDDLVVTLEKFGVKKTNLLTFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XSC4</accession>
    <name>A0A6G0XSC4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF5009 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_001864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000017">
        <property type="protein sequence ID" value="KAF0743391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XSC4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011678"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31061">
        <property type="entry name" value="LD22376P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31061:SF24">
        <property type="entry name" value="LD22376P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0743391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="42864" checksum="6C17EF8F3F721471" modified="2020-08-12" version="1">MPHTVCQMPEMVEEPLLDGRPRNADKRVRVVCLDVFRGITIFAMIFVNLGGGGLKAFTHVAWNGLEPADCVFPCFAWIMGVTLNISMASHAKKGTPLWRILLDSLIRSVKLFLLGLVVNNFRNLKTGRITGVLQSFAFAFFMTTVAIVLGLVLKSDTRSWQQRTIEGNVIGSLVLTNLLITFCLPVPGCPTGYIGNEIEGCTGGAHYYIDQKIFSDDHLYISGTNDPEGFLNWFMVAFMAYIGYVTGGFFLNAKVWTLKVAILTGSGVGLMLIGLGLAGFRVDGGTIPLNKQLWSLSFVLTVSGIASLVLCSMYLVVDKYAFWHGTPFKQNGMNAIALYVGHEVLGQHVPFGWDIDDDSKTDRVLSNLGGAICWTLIAVWMARKKIFITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XSH4</accession>
    <name>A0A6G0XSH4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_001698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000013">
        <property type="protein sequence ID" value="KAF0743549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XSH4"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0743549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="71" mass="7595" checksum="3ED79C105DB2067A" modified="2020-08-12" version="1">MDIFSAMPTEVETSNSSSTLMPARRMSEGVRAPAFKQAATSSNKSDILRSCDNDTLLEMLPAGAKEISTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XSI3</accession>
    <name>A0A6G0XSI3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="8">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_001914</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="8"/>
    <dbReference type="EMBL" id="VJMJ01000017">
        <property type="protein sequence ID" value="KAF0743443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XSI3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003884"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016971">
        <property type="term" value="F:flavin-dependent sulfhydryl oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039798">
        <property type="entry name" value="Sulfhydryl_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22897">
        <property type="entry name" value="QUIESCIN Q6-RELATED SULFHYDRYL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22897:SF8">
        <property type="entry name" value="SULFHYDRYL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04777">
        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="FAD-dependent thiol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 8" id="KW-0274">FAD</keyword>
    <keyword evidence="2 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026335458" description="Sulfhydryl oxidase" evidence="9">
        <location>
            <begin position="20"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="19"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="10">
        <location>
            <begin position="281"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0743443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="480" mass="53654" checksum="65C94DE0D0976DFD" modified="2020-08-12" version="1">MPSTLQVLALLIFVVPVAAFWGNAKPLFVKAPHIQHVTKENFKSVVLDSDKVWLLDFYAPWCPHCQHFAPHYETISGYYANSPLVRTGAVDCSTQDALCSEHEILGYPTMKLIHGDKFVVTMPPSGKIKTFKSVVKWVEATLDEHDLTSGVDINDIDDKEKMKNLRAQTETTLAPKSLESTGDIRVARLRDAGHALALSLDTGMFLGSNKLESHRYATAEKWLQVLSSRFPLQANRDVLATLLYRFQSQSSWTMPEWKTLIATWKTDSIGQTYPKDLFSRKQWDICTTYTCGIWQLFHSLTVTSPSTGGKSSENNVLVAFTIRDFVQNFFGCEVCVVHFTQANPDSTLAAIGKTSDSHSSLVLWLYHMHNSVNARTNHDRFPPAKDCPSCFDKGTVVEANVVKFMKEIYTVADSDALIHRPFEAMASAGYSGVSYVSWGDNPFAVCSFVFGSAFVMAVYSRYFRRGAPPLLDSSDYGKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XSK7</accession>
    <name>A0A6G0XSK7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_001788</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000015">
        <property type="protein sequence ID" value="KAF0743493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XSK7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019889"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="501"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="121"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0743493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="551" mass="61082" checksum="6E1FCB79579909F5" modified="2020-08-12" version="1">METPKSTRRSAKKTTSAVKQVEPTTDPPDNAHDVISSVPANPPDNPQHSIPNAQSDPPANAPTTFPVASNNPPSDPQLPIPAVPIDPLTNAQDPSLDVSNDPPSKASISTVSVPPAPTPSRLRSASRSTPAKSPKPQSKELSQQSKSPMLRASARKAKQNVPPTQPDATQESSADIVNQNVASLVASNTISGSIFAQCWKHLDSTRYAWQSIFTALVECETLCLHDHLKGKEPPPTTPLMSKVSFRCFDLSTLELQYVSERGTTQRIETILHHCEGIVRKLSKLDMTLMQAINTALSSIAEKKLASAVVYFHSVFQNPPEIMVGHISRLSASLARHYLRVIFLYFDDQLSEDKSSTTTVSQPSHYAHQDLGAAIHRALDDRLLFSTMQTTPKERFYYATSVEFLYKALHMVNHTTKDAYLSSLVRKLQNLCSRLVQCKCEDEAHLFPLGSFASFERTLKKELDAIDMKLVKNEYSIPRTPTKLLQLPEQESTPLKEKYRAGTACSECKQAWRDITSTVQCAACQRRYHLTCLYLSPTFRNLSGTYKCPHCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XSP9</accession>
    <name>A0A6G0XSP9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_001878</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000017">
        <property type="protein sequence ID" value="KAF0743405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011690"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034066">
        <property type="term" value="C:Ric1-Rgp1 guanyl-nucleotide exchange factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00136">
        <property type="entry name" value="PDZ_canonical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040096">
        <property type="entry name" value="Ric1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009771">
        <property type="entry name" value="RIC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22746:SF10">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR SUBUNIT RIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22746">
        <property type="entry name" value="RAB6A-GEF COMPLEX PARTNER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07064">
        <property type="entry name" value="RIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="374"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="ACB" evidence="4">
        <location>
            <begin position="467"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0743405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1284" mass="144232" checksum="099E9631C2072E5E" modified="2020-08-12" version="1">MWVARGPPRIVKREADAVVTLCSMGHWKAEATVNFIELRYLLYKDEPYPPQRLERNGSTPVAMAFLPSVQVNRLVVLTSMTLEMYRYSLDISEGLDFQLLEVIKFGRQDDIEGRCLAVNEENIFVGTSAAQVMLFRWAYVGNGGHVISPLESLHSIASTFPTLGVECLSIACNSSFLLTNRIVVAISLSNGLSILMSFTPETNTIEDLIPISQIEKSTVCALDADASVLAVGTMNSSVHVFRLTHTKKIELKSAAKTFQSIQVEETPLLLSLHTWGYQPDDIGPISCLEFTHDSRAIAIGYSQRGLSVFSIDGCKLMSTLPQHLGGSSSKNEVARHGVRALQWSHASSKLVITPSVAWRMTAQNTPKILSQEVTVELVKDEDGLCLSLAGEPNQNGAWVHSAQPFVKRSSDCTPGPAELSKKLNGGELLLAINGKAVWQSPFEDIVNEIKELPVGVSVSLTFLVISFQLVFPLAVDSLTNPAFREQHQLNWEEDHAIWEYSLRMQAIHGDCNMDVPSLMDFEARARFDSWSTLVNCSHQEATHRYAKLYLGLFPEWHPQHALQMLLPPPTPPQSSSSISLSNVLVMLDFARSVLPLGQSDLHLLESQSVVTISPRSLNDPCGVLTSISLSVPTNYAQVNQPMRLAAVNTSDTRLAVAGTYGFTLYNKRTSKWHVFGSEVEEQSFQVVAMSWWKDEVLVALVRQDDQLYLDSFPRNRLDLEARHSHITLSENCYALVVDERAIYCLSDSKVFVYRVTSSGALDNSNLHFSLHLFRTEPLPLCNAVVGHARCFKVVPRLQRRSSANSNGGSWFGGMWSLFSDTIPEWIMPRFLILDQLNCAYLWDPETKIQTLLASDVTHISSWSTPDDWPLLCSYMVGLYGRQGFQVWWPLMDNVVFGPPVDRNCIIQFLLAHDPYRAKSASSSLPKSLAWEDYSNLLAEYGVKLQNGVSFAESAIFVDPILKFNPEVQILGIHPWFGVLVGGLQDSYLGIFDLACRAQPFIHSTICYVLLQHQTDFARTILLSMQRRSALTTLTQELVLVAILDKCFQSKWNVEVLEKALILLKDPENEMETYCEIVANVARKVEPNRLPLLFPLAGDPSQLLQLCRQRNEIRTAANFLLCLDESITNEQASLRPRTNSFAQFQSRSGLAFELLVDCCEKEHLHLALQVVRVARAWEPEHYRSSNQQYDRYIDEQVGKYAFQMLVQHRFDKVVWLLTQVEATLPQLYGEELGIHEKNSTLIQTRLLALLTESQLRILHTAVVAARYDQWASLIKSLLDQPKRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XUC9</accession>
    <name>A0A6G0XUC9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_001264</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000010">
        <property type="protein sequence ID" value="KAF0744122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XUC9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003359"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF3">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026297632" description="AB hydrolase-1 domain-containing protein" evidence="5">
        <location>
            <begin position="20"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="577"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="641"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="651"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0744122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="685" mass="75782" checksum="E69583B0A666AF32" modified="2020-08-12" version="1">MRRGVAWLVVPALLSWATADPLTIRWYKCTFSTVESKSAAKDVEEPLMAECADIRMPLCHPGVCGDKSHDISVFVKRLPARTPRSPPQALWMLQGGPGHASTAMESLMHNSYEASNGTISVYTMDHRGTGRSTLLECPEEAHSEDEIVDCLEAIKKRHGNDAPKGFSVTSAATDLQLVVESSLFNSTEVYVYGVSYGTYLVERLMHLAPKQVKGYILDSIQSEQFYTTKSAPYYSNWDRDVYEVVHQFFAYCDADAFCKGKIGPKSKQTLLQTYLALDAAQTECFDILYKVAHDGGYAKPSGVVGQTLYNWLTDREKRVFIPAYIFRLGRCNADDQVWLQQLTYPPAMEIPDESPYLKGTGYSDVVYNNIVFSEIWQSSPSSPTAQELYEDSVNALLSLGNIVYAKNRAQIYCIYKQNADPMCKEYPMYDVSFTYDHDAYWNHTASIPEGTSVLMFTGALDTATPSKYAHDENATMGGGAKKRLIEFPFANHGVVMNTPDEDNEEVHCGVLILDSNLAKRGDVAAIDTSCVDHMEKLKFSHWDRDLAFELFGSENPYNQSVVQVKLSAIIKNKLKTAFTTGVVVLTALLVVSVGVLIFVVLENRALRQQLIVSATAADSARNLESQPLTTDDAVDITEVTATTTEVDDDQPNASTTTTEGTALGPEVTQPTLASAENLDEHNVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XUL5</accession>
    <name>A0A6G0XUL5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_000838</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the non-repetitive/WGA-negative nucleoporin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016841"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036228">
        <property type="term" value="P:protein localization to nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000972">
        <property type="term" value="P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1880">
        <property type="entry name" value="Nucleoporin, helical C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.440">
        <property type="entry name" value="Nucleoporin, helical domain, central subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.450">
        <property type="entry name" value="Nucleoporin, helical domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007187">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014908">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004870">
        <property type="entry name" value="Nucleoporin_Nup155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042533">
        <property type="entry name" value="Nucleoporin_Nup155_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042537">
        <property type="entry name" value="Nucleoporin_Nup155_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042538">
        <property type="entry name" value="Nucleoporin_Nup155_C_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10350">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10350:SF6">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03177">
        <property type="entry name" value="Nucleoporin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08801">
        <property type="entry name" value="Nucleoporin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like N-terminal" evidence="7">
        <location>
            <begin position="77"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like C-terminal" evidence="6">
        <location>
            <begin position="651"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="496"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="510"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0744350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1350" mass="150847" checksum="1BEC6114BA4172E5" modified="2020-08-12" version="1">MGAPEELSMANVSVEHEETEALSQSHKVLEQAYSVDSKSPDLVDQIADHSEPTSHNYFFEPYSSTSRGWQPQLVHKQQLLPYPLAITSAYENMRSGSFSGLLQEIHHAWVSVDNTLFLWDYTRSERLTAFEGMEQMITAVAIATPIAGVFKSFVKHILVVATASEMRLLVVLYENNDPVNGALRLQASKLCISTDDCTVKKIVTTPNGRIFFGGSDGQVHEFVYDAEETMLHQLGWKRKCRKESHSQSLSNYIPTIFRTLTGSLTSSAKIVDMLVDAERRILYVVQEPATISVYDVAEAEVKLVAAKDIHAEATRFCQRNHRTWTSCPEPRLFSNSTITITSLSVVGRDESASIHAVAVSSSGIRFYLSTFTAGFFSSNTLKRPNLLDVMHIRLPPPMLSLEDAPEYHVTEGLAPAILAGKSPSQVHKAYYRKGVFLAVDGGPDAFDSVIGLCQDNTARHNQDANATNLKRLMRESISADSCQGKVSDVQEYVEYKPDTSKSDAAPSGGQKRTFSEMNGSNTNGALPAEEPKAMLSELVSQFFNPPRRFLVLTNAGLHIFEKVRPLDQLSRILHSTGKELTAKLTHFVKCFGQAEICAMLFAIATEESSAITLVALQSIFEFGGKPGVAPSGPNPGGNSNSFILTDDMCMSYHHDGLVKFLARVLRPFWHSTSRVTSIASVRTVLLRLQSILATQYASALEHPPMATTEPSRFNSMTRALNSLVYESNPASLREENAIRAEQFSIRCLYRFTVRAVETLSLLVASYEHNASFTSPLPLAELVTTPPGAAACKVLIQHLMGVSGHSEGLVHQLRAQCPSLFADTDAAQSHGFQALEMAADCVTVHDQEVVLKKSLDHFRLASKTWTTEDQLSVLDTICSSYFAVGFLDGIVDLSLACARQLNKPDMANLRRLAYSNVLQCLHFFLLPNHDTLSICEKVPNAWTTPQGKEEVANQLLKRALASSDMQLHSVLYTWLHDNGQEKRLISLPSSHVETFLKSKDEELLIKQYLLQERYVDAAHILWNQAQEQNPVLESNRDVSQRLELMSRAASVLAAANNPAAANALDEVREALDVMQLQHNIWRTLEGKVEPNVQELKYRILDVSVLYNQYASKHHLWSDCLRIIRACNTQDPNIIQHLWEQILFVLIPKSASNAIFNQWIETKYHDRGTTNASSSNGSSNSDNTFESARWISHVQSQITPLGKELVGSSAFPVEFLLHELEHLWMWYIQLTQFKKPTNWITPFFIYCGVSYAHLFGVYNKLYENNQAPRWRFHLLSSIYDLVRTWQTTIQNRPSRETILAFATATPLLMSACEAYIVDLHALVGDGHSEKHHMIALFRQLHADVVTTKSTYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XVR4</accession>
    <name>A0A6G0XVR4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_001205</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XVR4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002217"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008506">
        <property type="term" value="F:sucrose:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432:SF26">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13347">
        <property type="entry name" value="MFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="429"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="464"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0744750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="491" mass="53274" checksum="C16A09371E29A7F1" modified="2020-08-12" version="1">MPMPRVIVEHSQSFIDGEARVAMADEPAKPADGCSVPFMFLLCAPRLAMNMAWAAQWAALGPVLHTLFPGKLWGVNLIQCIGPVVGIIVCPTIGVLSDNCTSRFGRRRPFLFWGTVATVACWAIMMNAETFGESIGHDESSRRTAKAVLFVLTYTWMDISVNVAQVPAILIVADFAGDRQLLASSIAQIYFVCGGLVVSGWNSLYGTMDATNKYHPFFYLLMGVLLVTVLPVCYFAQETVYVPDDMDRSRYDRLRDGFSAVYNSLRYLPRLLGVYFVCILLLQFGYQAYNSNKGDYFGAFVKGGTANATDKCNYRGRKATGNYSECSVEQTLYLDGVSVATGVTDTIQILVGLVWVATLPFLVNLYGVRRVFLASIVPQFSLAVLVFSKNIPVNLVAVTACGITQNTLFALQIPLILHVIGFGEQAGLGLFAGALNSAITIGQLLTTAQSAIAGAVTTQAVAPWPILVGAIATVVAFVIAFLKFTVRMNTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XW56</accession>
    <name>A0A6G0XW56_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_001228</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XW56"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002977"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="181"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0744774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="467" mass="52208" checksum="88DF4E72CD692856" modified="2020-08-12" version="1">MGDDGAVAAKQVLLDDITELEAAAKQVVDEADAIRLKAGLLLSKTSASLKRAVDHMDTVEHPQDILMGFVAWIETVFMVKNIAGLRKLAGAYVTMDTGAVQAFLKADENVTILSYANEASSCNFFPATKSVTKPIETEEKLKVHVPPEEHKKETTATEKVTTAVSKPTKQKTIIFASSKHKGKDANAIAPPGSALNKVSKRPVDTIVVDSPPPVKKTKNKEQPKPVSPDATKAPQPRKQHSKLVAAVEAQEQNEVNSPVEGSRRTSGRSAAMSADFLRRERDSQFRENEQERQDLAAAILNSKKEMDNPANEQTEEAVDCAVRTEYDSIVQAKPWVKWSSHFQSFMLDDSPRRKSFNDDLKTFFKTHAQVLWERFFWLGLGHQKEHKLRLQAAQSAFIRLIFRLHMMEGDNVFKFIMRAPHPAWPTFLSTPIALNQMTTEEAIEYLKTQSTCRWPKTPKPNLGHTNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XXJ9</accession>
    <name>A0A6G0XXJ9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SUN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_000361</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XXJ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006851"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034993">
        <property type="term" value="C:meiotic nuclear membrane microtubule tethering complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045119">
        <property type="entry name" value="SUN1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911:SF8">
        <property type="entry name" value="KLAROID PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911">
        <property type="entry name" value="SAD1/UNC-84-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="SUN" evidence="7">
        <location>
            <begin position="341"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0745334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="540" mass="60190" checksum="AE4181A96307DE8E" modified="2020-08-12" version="1">METPPPKRGRRWNMETPQKDRDDDILSDATPFNSPAPSDRTFAADNDENEGTFAFDEEEEENDVQFVQQNKVGFGKRVRKITASGFRMLVEILNYTWFLLPFLCLIVALVLPRYLITAIQASPTSLTSPGRAASFSTIQVQMDTIIKDISSFKKFQQEQEARIEEITFLYEQSSKNIDTLLDRARTSTGDIPTSVLDHVSEMIQAAVKKSTRELKNEYKTALQPLETGLRQITTQASLFENDLKTYKTLVEDVEELVESNKKHVLEAVQDATNPQATEQKVSAIVSAEIALVQDKMTRLLTDEATRLEHKHSQALQTLRNSTLSHIDQLVGQSAGQAHTFPSKAIIDYASSSSGARVLRFQSDLSSHKLIGVVQSLFSESPFTSKTFNAFPLCSILGSSCPLLNQHPESAITDNVDPGNCWTMEGASGSLSVKLAYPIVPQSVEIYHIDPSIAVDFGSAPKDIQVIGLVLDDKSKDVRHVNFGSFQYLKNGGTSQRFFLNDQASTTKVVGMTLRVLSNHGNDKFTCLYRFSVYGSRFFKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W364</accession>
    <name>A0A6G0W364_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_019140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000415">
        <property type="protein sequence ID" value="KAF0721430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W364"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004744"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017383"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35871:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35871">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0721430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="640" mass="71665" checksum="3F08F09821C3916F" modified="2020-08-12" version="1" fragment="single">MREQKSTREEAANAAVSMAKTFDDSIRICGWTVQCWAKHFMHHGAPPTSRRGLHQKTASLIHDEDVVSKCLQWLRLTLPSQRTPFRVQQHRQEHVLPSTTGAIRANVSLRTAERWMNKAGYFYGLAKKDVYIDGHERADVVKQRGEFCQTWIMMSQRMSFYAGENMKEHFAPEDTSQPEVVWITHDESIFYANDNGGKVWLSQSCPDLGKKGRGRSIMVSDFLCPCHGRLHDGKEFVTAILHVGKTHEGYWTSEHAIHQLKSKVLPAFTQLHPGKVAMFTFDQSTNHAAFAPDAWRASNMNLHSGGKQGLLRDGWLASQLVVDRYGLSLRLFSQLAFEKGSSDTSGYINRVLCSLSKEIDSALLIRNLRSHSSRRGAAATAASSSDVNLSDLADRGRWTMDGFNTLLEYISETSASDQKVARALGGWQHPTRNVQRLFTKSLFQHYSTRLKKDSFQQALAASLLLYFPDTRAACQSHVLHTAMIDAVKACDNSKNDEQAVDVLLEWAAAIKKSFISDNMQCLPISTSGAVDFVHSTKISLGDTLARFSSAQRDVAAEITDLSGKLELQNRHHEQVKRELTSLHRNFDQLSNDHRTALNTISAQQNTILDMLSRLTDTTIQLEKRKTPSAADSTLASSLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W3G0</accession>
    <name>A0A6G0W3G0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_019106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000392">
        <property type="protein sequence ID" value="KAF0721512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W3G0"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33205">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33205:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0721512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="133" mass="15766" checksum="A1F234BE0CAE4462" modified="2020-08-12" version="1">MHRIHTRNDTVPFQQFQVLFNSLFKVLFIFPSRYLFAIGLAPIFSFRWNLPPALSCIPKQLDSKKAYRTHRQPEQRREYHPPCCPLPRDLSQTTIRHLRGDFKLELFPLHSPLLRESLLVSFPPLNYMLKFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W418</accession>
    <name>A0A6G0W418_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_018957</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000369">
        <property type="protein sequence ID" value="KAF0721717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W418"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005528"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051631">
        <property type="entry name" value="Ankyrin-KH/SAM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23206">
        <property type="entry name" value="MASK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23206:SF7">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="39"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="72"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="105"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="138"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="171"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="204"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="237"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="270"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="303"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="336"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="369"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="402"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="435"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="468"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="501"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="534"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="567"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="600"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="902"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="929"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0721717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1165" mass="126901" checksum="4B7F5555CFC46F15" modified="2020-08-12" version="1">MAKKGSKEEQLLEAAAAGDVEKVRALLAFHPDIKFTDESGETALHKASRYGSLDIVKEMLAHGMSINLVDKIGWTPLNSASNKGYLDVVMELLAHGAAIDVASNNGWTPLNNAASKGHVDVVKALLAHGASIDVANDDGWTPLNTASSNGHLNVVKELLAHRASIDVASNNGWTPLKSASSTGQLDIVKALVAQGASIDVPSDDGWTPLNIASSAGHLDVVKELLAHGASIDVPSNDGWTILNNASSTGHLEVVKELLAHGAFVDVPSNDGWTPLNSAANNGHLEVVKELLAHGASIDVANNDGLTPLNNASNKGFLDVVQELLAQRASIDVASKNNWTPVNNAASKGHLDVVKELLAHGASIDVPSKNGWTPLSSASSTGHVDIVKALLACGASIDLASKDGWTPLNSASSTGHLEVVKELLAHGASIDMPSNDGWTPLNNASSTGHLSVVKELLAHGASIDLPSNNDWTPQNSAANNGHLAVVKELLAHGASIDVANNDGLTPLNSASNNGHLEVVKELLARGASIDVASHNSWTPVNNAASKGHLDVVKELLAHGASIDMPSKNGWTPLNTASSNGHLAVVKELLAYGASIDVANNDGWTPLISASRHGHIDILSVLLNAGAEFEGNHARVRDYGNNQVQAFLDSFQPPEIYSIALATEFIYHAIEEFKTTTSDITVQGTAILKLSLKVQIHRQRILTTGLMVKDILRQVVRQKSRRDLTLLAVLNEMKNFFQMPLLTTHSWNFCLPAQTIAAIGANIMRLQDALVESAKSLQIHFFRRLLALGKIDDMRRVFGKMMDTVENIDASLKTISEMSDERQLDRLVELAIQLQRGLDQYQGHVKLRNFQRNVQFEKQVASCQSKICSAINKLNETRNISNAFELHKIESWMLSSEDIEFDPNDIEKTLGRGGFATVFKGTYYGQLVAVKRFHENLDTDSADLEKLISKEIKAWKDISDAPFILSLIGVCTKIPRPILVSELCQTNIRRYVRDRRETLIPMLYQFACGLACIHKANIIHRDLKGDNVLVTYRKTVAIADFGLSRSATSLKNTNIKPTGTLNWMSPEQYFIPRTVTVKSDVWSFGMTLWEILCNETPFRICSEDEFRHSIFQTEDDRPEKPDDLAPQLEPLWTLITTCWQLNPVARPSADEILDFFKTHYSSQIIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W4T8</accession>
    <name>A0A6G0W4T8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">Ae201684_018925</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000367">
        <property type="protein sequence ID" value="KAF0721747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W4T8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011135"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021449"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0229">DNA integration</keyword>
    <keyword evidence="15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="13" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="14" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel" evidence="18">
        <location>
            <begin position="3"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="GAG-pre-integrase" evidence="17">
        <location>
            <begin position="80"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="286"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF13976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF22936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF0721747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="315" mass="35545" checksum="F977BB1889902072" modified="2020-08-12" version="1">MPKMANDGSIKSTQCGPVSIQVDKDQVLTRDQVMYVPGLTKNLLSLRKLLQDGFKIAKWTSDSAIQIKDTLALKSQVQHGLYVLCVGQEEVNAFTVRKEIPKIVLWHLRLAHLNFGAIKQAAKDGVVEGLTLNPSDYKQSFSCETREVAKAKRMSYKQTHPYRAQVAMERCHIDKGEPIHLQRQNPLRAVKSETLTNFKNFYVYAERQFGHQVKNIMTDNAKEYVDKNLKAYCSNLGIEQLFTSNYSPEENCSILATATLKFSLHVEVTPMHLKITTLTPMLTTGNTTSHDHDNDDTSSHIIPNRSVGDVDEVHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W503</accession>
    <name>A0A6G0W503_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_018670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000346">
        <property type="protein sequence ID" value="KAF0722131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W503"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014701"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052050">
        <property type="entry name" value="SecEffector_AnkRepeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586:SF3">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0722131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="179" mass="19977" checksum="B95F86154D3F46AD" modified="2020-08-12" version="1">MTVAGLIFEFQAGLYLDLAVLLSEFHAQSFFHEEERALALLRALHADETTQFLARYITCRPSSLTHELVDASAQLGYTKAVEFLCGLGLPHSDFAIAGAANQGHVDVVAIFYHHGQPTRQSIQIALNHAAHAGQFRVVQFLYENRLKALTIVPILYAANGGHKEVERFLRERYEATLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W5A2</accession>
    <name>A0A6G0W5A2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ketoreductase (KR) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_018609</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000343">
        <property type="protein sequence ID" value="KAF0722227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W5A2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013793"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43490">
        <property type="entry name" value="(+)-NEOMENTHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43490:SF99">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0722227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="15949" checksum="DA9B3EA803EBFA72" modified="2020-08-12" version="1">MQNGEAAVAKIKQANPSFDYANVQLVQIDVSKKESIQAAADFVKSKYGNVHVLINNVGIDGDAEGAEMCFNVNIFGVYDTLVAFHPLMVPNQSSNIVVASTLGASSLSAMPRSLRPVFEDFNKLDISTVRSLVDDWIASAHGKPSEHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W5V0</accession>
    <name>A0A6G0W5V0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_018627</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000345">
        <property type="protein sequence ID" value="KAF0722147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W5V0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011212"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0722147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="308" mass="35171" checksum="6100F5BB863CC3E2" modified="2020-08-12" version="1">MHDDDGCRGDLCIIVWTRIRYKTIHPSGYSLIWLAWTFAKPKRARRGLKSVVATVVVGFFLPRDGWQYLFRSQDHETNDKIQRSRSWTESRSPFFLFAQRQPRTNHMATAHPTRAFNGCHFGDVNLNWVGVIRIKASCRNVAIFDWLEYPESYFWTEMALAWLSRRGHAYVALLVLGMIICFVCMFVQKPPYWDEPPPPFNTTACSACANSTQWPCPNVFTTGSLTNAIACNPRTIVCCCPAGYDEAGTRVGCAYSWTETTCKCRHERSCGEFCFIYESLPPMIVGLALGAVLFVIGVRSLCRRCRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W625</accession>
    <name>A0A6G0W625_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_019119</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000400">
        <property type="protein sequence ID" value="KAF0721480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W625"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014452"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051558">
        <property type="entry name" value="Metallophosphoesterase_PAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10161">
        <property type="entry name" value="TARTRATE-RESISTANT ACID PHOSPHATASE TYPE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10161:SF14">
        <property type="entry name" value="TARTRATE-RESISTANT ACID PHOSPHATASE TYPE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026252229" description="Calcineurin-like phosphoesterase domain-containing protein" evidence="3">
        <location>
            <begin position="17"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="4">
        <location>
            <begin position="35"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0721480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="395" mass="43653" checksum="B555D3877D0ACEF9" modified="2020-08-12" version="1" fragment="single">MRAALFLLALAVAAKSAQLGCDLEDPETSKPAITILALGDWGGTLGKDNGDGGSCCRMYNGTVDTRSTRYQVDFYAQAYVGMLMGQSAAQLHPARILSHGDNFYWNGVGPADAKYRFEESFEKVYNAPSLLTVPWLNVAGNHDIGGANFMCGEADGQFRECDSLEELLKYMDIRFEAQAKYKSPNHDRWILRDHYYVERVTRGAVSVDVFNIDTNYADNHGALQVCCQCYGYAPKLGISTSVCGNPQPGELGCVGGNRTLFQACMDKISGWGEESLQRALHDVAASTATFKIINTHFSPHYHMNTTKMNQWYNVCENAGVTAWFNGHTHAFNHDISSWGTHFFQNGGGGGIITETSPTINNTQVKTQWFAPGTPYGFLELSFSHDWLKVQFATFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W6M2</accession>
    <name>A0A6G0W6M2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WRKY19-like zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_018917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000365">
        <property type="protein sequence ID" value="KAF0721774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W6M2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012476"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056866">
        <property type="entry name" value="Znf_WRKY19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827:SF1">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24906">
        <property type="entry name" value="Zf_WRKY19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WRKY19-like zinc finger" evidence="1">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0721774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="176" mass="19194" checksum="A297773CFFD424B2" modified="2020-08-12" version="1">MPLDTSAVELLLNPDMDVSSVTVIPDVRLSISFLCESALPTPSVAVSLPSLSPKNKAPTVEKPQQESRTCVVINCRNKIKRNHVCWRHGGFRNCTVVGCSNRVKARGLCWSHGGGKRCISPGCLTTALRYGLCWAHGGGKRCVFEGCNRPAYERNKNRCDLHCSAPRTARTTTVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W855</accession>
    <name>A0A6G0W855_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_018497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000337">
        <property type="protein sequence ID" value="KAF0722370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W855"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014526"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="1">
        <location>
            <begin position="3"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0722370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="305" mass="32974" checksum="65A86F67904EEA10" modified="2020-08-12" version="1">MIAPKTSAFCGEPGVYTQEQLVAWKSITDAVHAKGGKMFMQIWHSGRAAHPIYNDGAENVGPSAIAIDTDITNPLGFADEKLANATPRPLDIAELHALAQLYATAAKNCVDVAGFDGVEIHAANGYLIDSFLRESANTRTDQYGGSLENRTRFLSDVLGAVTAAIGADKVGIRFSPLNSCNSMKTDDPLAFSEAVAKLSQQFDLAYVHVMRDDFFRLQKADVVPIFRQHFKNALIVNMGYTKDEANAGIAAGLFDAVTFGTPFIANPDLPLRFQLDAPLNTPDTSTFYVGGANGYTDYPFLSRHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W8M4</accession>
    <name>A0A6G0W8M4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_017608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000304">
        <property type="protein sequence ID" value="KAF0723528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W8M4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013822"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0723528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="415" mass="45942" checksum="8039246F2FA99998" modified="2020-08-12" version="1">MLVSARCLRRIWPHAAQKSTLTALQMDRNSDFRPSSSTASTAPTTAASQPTGLPSSADDFATKLMQLVRDRHKEEAAKLVEHVTKESIPLDFDQIYHAAVRESKLHINAFAFVMAAHPNAFAPRLRLEALRGCLGSKNYRGAIRLFEGLEDLMIPPSELNKPLLQLLRDMADRPPEELKGLRNAQYLVTDYVMFRNAAKTNIETLLETVQACNASILPSCIKLLVYSSFGAPQAEWATKLDHVKAMLSFCLKHSIALPDTWCFTTAFLKANVASLPALEFSKLYLDMVEANLIQPSMEASWPSLQVVVNEEAPELVQPSIRTLMAGNMTRQMYHFGLFWCLEAGDGGLAKQLFAKLTASPSIAPNGKTLSLIVPLLEGAPADQIHAVLAYFAKFNVFPTREEYMALFNDGRQGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W9D7</accession>
    <name>A0A6G0W9D7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_017405</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000296">
        <property type="protein sequence ID" value="KAF0723732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W9D7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013628"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF288">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0723732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="294" mass="33690" checksum="119CCD9C28233854" modified="2020-08-12" version="1">MQVQNNADLTSILKPWEQSWALVALRQSSRERTKGNLCCETITSSASHRFGRFTCAVKRLHRVPRTDLDDLRRLIALEINGWRQISHEPYILTLLGVCTTIPTPIIVTELCQTNIRRYVRDHPETLLPVVYQFAKGLVSIHNANLIHQNLKADNVLVTFQKKVVIADFGESLLAQDVSPDTQARGTLNWMSPEQYLNPQSMTTKTDIWSFGMTLREVLCNETPYRNCMEHEFRDEIFCSKDDRPEKPDALDPQLEPLWTLITMCWQLNPEARPSAVGIVAFLEMHFSAQVVETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WA13</accession>
    <name>A0A6G0WA13_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine protease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_017212</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000286">
        <property type="protein sequence ID" value="KAF0724047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WA13"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013213"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36234">
        <property type="entry name" value="LYSYL ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36234:SF5">
        <property type="entry name" value="LYSYL ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13365">
        <property type="entry name" value="Trypsin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026068055" description="Serine protease" evidence="3">
        <location>
            <begin position="19"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="366"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="370"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="416"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="431"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="444"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0724047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="463" mass="48488" checksum="87B79F20D7CFC069" modified="2020-08-12" version="1">MQRLAVAVLTLASGSVQAAMAVLGADHNLTAVVANVDAPMTHTILELSAVYVAPHFDFIAVPPGGYITVSAPDGSQAVNYTGSRRDFYAEYIQGEAALITYTPPTDIVQASPDNAFVIDRYASGAGETAAIEAICGNDDTKPAVCFKVLDPPKYKATQAVARLLINGTSLCTGWLFGSEGHLITNNHCIPNAQTASNIQFEFGAECATCDDPNGAVQLGCKGQVVATSAEFINTDHTLDYTLVKLNVKDNTSLAKFGYLQARWTAPELGEPIYIPQHPGGKPSRIATLLDNQTIGTIESTSIQTCSPDEVGYSLDTEPGASGSPVISTKDNTVIALHNCGGCFNGAIKLNKIVDQLTQLKLLPANAVKGTSPSPNTTTPATTPSRPTRAPATSRPNSPAPTLPTTTPSPSSPVPSQPTSSPAPSSRPSMPCKHKTRKPKKPKQPKTTVPSSTPSTTDANDGSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WA98</accession>
    <name>A0A6G0WA98_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA ligase (ATP)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_017801</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000313">
        <property type="protein sequence ID" value="KAF0723180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WA98"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004122"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07896">
        <property type="entry name" value="Adenylation_kDNA_ligase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08041">
        <property type="entry name" value="OBF_kDNA_ligase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029319">
        <property type="entry name" value="DNA_ligase_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050326">
        <property type="entry name" value="NAD_dep_DNA_ligaseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006592">
        <property type="entry name" value="PRK09125.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47810">
        <property type="entry name" value="DNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47810:SF1">
        <property type="entry name" value="DNA LIGASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14743">
        <property type="entry name" value="DNA_ligase_OB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BRCT" evidence="7">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="SWIM-type" evidence="8">
        <location>
            <begin position="212"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0723180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="539" mass="59069" checksum="8242C5A024B11FA9" modified="2020-08-12" version="1">MSTLLHGKVIAITGKLSLGSRDDVAKLIQAHGGVMASSVTKGVTHLVTNDPSGTSSKLVQARKWGIEIVGEDFLTALAPANASAIEPPTKKLKQEVNPTIAIEGRVFTFIGDLDLDRQECIRYIESKGGSYVERLSDKVTDAVIKDARSSSPELTKAQSQGVNLVTEAAMTQLIFSDMFGEEEAAADNNAPMPNRVMTDGEAISVPGNSSNYEVRYRGGVYYCTCMGWKMQNKAVDARSCKHLKQILGEPFELWRTTGSTNPGAASKATSSTMAKQTAPKLLLAQKWEAQDVVGWWISEKFDGVRGYWNGTTFLSRLGNPFYAPHFFTQGLPTDHHLDGELFLGRGRFEQTVSIVKSQNLDDKWKTLKFMVFDVPTLPGDFETRMEYLQTKIAPTCPYAVIVEHKMCTSEAMLLDTLKAVEAEGAEGLMLRQPKSLYVKARSSTLLKVKTFSDDEAIVTGYEKGKGKYAGMTGSLKVRNRDGKTFAVGSGLTDALRTNPPPVATIITYRFQEKTQAGIPRFPTFVGIAIDKVWDEKTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WCB5</accession>
    <name>A0A6G0WCB5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_016780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000267">
        <property type="protein sequence ID" value="KAF0724572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WCB5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015767"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051876">
        <property type="entry name" value="ODA-DC/CCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21694">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21694:SF18">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="433"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="497"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="765"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="433"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="466"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="497"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0724572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="986" mass="111576" checksum="4632E192D5C0C4B3" modified="2020-08-12" version="1">MTDMESPALIKTRAPRDKQKNKERAKENRRLQKEEFEYLQNRVAELTSQLRGHTKMLPWREIASALQAESSTAQTTNRTLRRDIQRTKDILQCLLVMVCGTASRMPETSPIVQISGWKDQALLGIDGDARVASYRWLINRLFHNTDLAYAQCPNTPSVLIDVKCDDHVVTTFIRTHYVAPVPMDQAVRTIQGLYKWDFFVDIDRPICFYDKELLEESFGPNTFHVDYEYKTTIVESCRESSCRTVFARCCVNFDAAHQHVDRYERCDHEWRILEPLSDSTCRILHFRSVSLPVAISNDEFATITGARLDNVKQWTESERLENLMKQRYEMLLVQSLQIQGLNISLGFIGRIGLINGYSIIAGGMAFTTRFLASDGIPEYNALLDQHLGRHRNRLLGSKASLELLEKTGAISKVAPGRSADQYVVYIDSPKVSASQPQAQQQSQRKPKPATQTSTRTVPAKRVVKRRATEKIEPLSDRPSPPLVASSSLLRSASDSFIRQAQNTSRRPATSQKRAAKPVVNHLLESDVAFHEKINRYKAQIAALDEEKLRIQEEITRRRKALCGVNAVHDNDMAVAHCHAVMQHRLSKAQEEYMKVLTHQASIRADIDVARRELLAMSQVRCKLETDVAEANQKISNAEDRINTTRNAQKSTFAELSTLERQAEADAVERILKLPPEDDMVNMDIPKFMQSIHDRALLRKEELERAKAATLQAAIPPSNPLCDFDPIYRDAFQAIKQAVTVPPTVNEFVDTFVETENQILSMYAHQQVLQAELKKAQQELESLQVQARVAKQQLQKQRDDATSWKTHLQEKIALVRRKTTEYESLHGNQKHDEIVLRSSILHLLEVLKADKLILHSNGMVNHVQDLPLPTILGIAQERIVDVIIHVQQTKGTSGIATTTVQIHPRSHHARRSPSMETPSLVGKVVVGPRIPPAYTGSNLPSFEAMANATALPDLLNAESSVDHAFVPLSSYQLFERALRNDDVDQDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WCG4</accession>
    <name>A0A6G0WCG4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_016538</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000257">
        <property type="protein sequence ID" value="KAF0724887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002786"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34894:SF5">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34894">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE RSMI, CONSERVED SITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="1148"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0724887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1374" mass="154698" checksum="3885691EB0EA1F46" modified="2020-08-12" version="1">MQRVPLSPKRAAPLKHRSPRKQKEKPDILPVPPTIPRGIYNFHEGLPSWNNQEAASVSPQKGRRKRPDLQPLKGNPPPAVQSIVATSIAADSLDQRLNSIKQQIEHVLQGGMLKDENSTQTNSSESPRPMTIETSSIISPISLRSTVLPAINASPEAIARSQAYLCADADIEKWIQDYEADKHRFTSYALFTEFKLDQLTAFVANTGRPNVIETAACCAALFKIPGILGAYRSLLQKIVVGLEYGLYGDSICESSFQENDDIATRRMQDASTVEIVRSFYRRKPYFVQLRELEHDHALSMHLGGSRRSTTLLDHDKRRVIEQCSPELLEYGLLRFSDQVRQQIGMKLVSSVRQESLGKAHMSDVCRRLLKLSESLDMESRAMVVTGILDDLDGENRASACFKGLGPEGEARVLELILGRDDRERFVLQETLTRVTDAHCLLHFYVHACEAYRLNFLREILHHKFEYEFICDLAKIISTDQLEQLTDFVNGARRVVSQSTGLGMSADQLHTLLTASDTFPKAFTTSEQRRIFEDVCALLRRWPSQALDFGELLIEKFRSLHPRQRLMALTALLADNFHATKEILEDYFSTLSSTEKGEIQVLLGEYATTSSSSPFMLISFKEQLTTMAPDMRANVLYAILERIRSSLGDDDDISQSKAVKTLSLYCRELFGMTIVIDPKGRQAPTSKRAPTTTQAAAQTLEVLHQLDDPTRNTIIESLVQTIPAAPKSPVMTDAEAKVELPDERKAIMLAAISQLSLQEQIVSGLTEEDTSELMAHAMNKPENEFAKVAHAVISTLEATGQASTVEKIVERLLVTTRERRDTMTDEQRQFFQQANMMDKLSTIHEMTWRHAQQEVHNERDDDDDDSQDENTLTKFGMINVACQTDLSSESDDAGAPDIVDDNANVQKRQNPVTLPSLMKKGKGKKICKIDSSAVPDSLASLVTSWKINADQLAMCCKKNLSTVLRTIADTYAEKIMRIKRGNNGKKDSLADITYQSLLHSYGLPSIADMHIIGLAVAMDQFRTHNSRVDMFCQFLYNETPEWLLRNYLNFVELLLDESTEPVEDPNGVRKKPTRIARLNIPDKETWTVSMDHAIEVAQSCFRTMRRTSVAAFCEKLMQSTPREDKDESVVNVDDLLQLVVVEWQDEQLRREKHLRDAFRAGDNNGDGVLSYEEFRRIVLSIDKTRDNSDILNMFSDTLRRTNTDAITPEDFLVVAKEYGLAEMAWDADGDLNSIVNGLAEMDMMWPGVQPFFVGSIQVLERNLPPTHALHTCQGPGCGCLKCIVDGYAVFLAMREEATDDTQHAAAIWKRFWHLMSQLYEACDKSDGMVWMDRQAPPRGSILRSNNTRRSALPNILLPDVGRISAKQHRDDDPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WCQ3</accession>
    <name>A0A6G0WCQ3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ae201684_016655</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000265">
        <property type="protein sequence ID" value="KAF0724724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WCQ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020712"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0229">DNA integration</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Retroviral polymerase SH3-like" evidence="13">
        <location>
            <begin position="54"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="12">
        <location>
            <begin position="226"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="156"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF25597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF0724724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="336" mass="38635" checksum="1DC8933B61F4A731" modified="2020-08-12" version="1">MTVSGLPAALWGYALEHFIYVYNNTPQELLNQRTPYEALFGKPSRLQMLTTFGCLAYMFVPKSERTSKLSNPAIPCVFVGYAKNKLGYSLYNPNTRTIQTSRSVQFDETKLRNGSMFHFRAGRLVMLALDDKLFNDRFDATDDGFHEPEIEADTEVESHLHDRKQPEPRQSKWTIKRPKRFEVNNVSLGTAIKIVEPQTFQDLDKKDHSVQWIAATNAKYQAKMTNNVWDLAPQPPNRKALKSKRVWKAQYNEDGSLERLKARVCLKGYLQIAGVDFTDPYAPVLCLDSLRILRALIAKFDVETAFLNVDLEEDIYMEQPELYQVEGKTHLVCKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WD70</accession>
    <name>A0A6G0WD70_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_016222</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000245">
        <property type="protein sequence ID" value="KAF0725279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WD70"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006582"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000027">
        <property type="entry name" value="Heat shock transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF206">
        <property type="entry name" value="HSF-TYPE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="8">
        <location>
            <begin position="11"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="131"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0725279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="257" mass="29167" checksum="3E76B6117B2A859C" modified="2020-08-12" version="1">MKHSIKSKVEAAPLFLQKIYTMFEDAPARVAGWANRGTTVVIKEPEEFAKTILPQYFKHSNFSSFVRQLNFYGFRKFKKDDILIQDHDSTRHWWEFRHEKFLRHAPELMAQIRRKTYSESSENGSDASSDVDMLKSQVKAMQAQFDALTTQIQSLTTVVNDLVHSKKRALEEEDLEDETDKRMKMEDDLPPIAPVLTQQHSLMADDILADDATLDPVAWLDGLDFSAPMVQLCSSGNSSGGGPLSFLIALKPQKTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WDG8</accession>
    <name>A0A6G0WDG8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PWI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_016127</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000243">
        <property type="protein sequence ID" value="KAF0725356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WDG8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010165"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="333"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="11"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="333"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0725356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="372" mass="42617" checksum="E23F7D457B4DC905" modified="2020-08-12" version="1">MATLESLEDGLEARLAANRRMQDDLEEMEARIIAFLNETDIDLNPAVENVSCQCIPEHFVPSESLASHLKRCHGIQQPDVTTCEFFYRHIPSVENVRATHQEPIQFAPSADPKAHFVDVISNPYEEATTDISFDEEVQSIVDTSTPASASNAFEKAVGTIAPQRQEFRDQVAGWKLIPAAFTSLDATRLHLPRIQAWIETWFETEKLQGKRDLVQYILGLFNQPSFCSPDLFVAELVDFLGIHTRRFVLALWKFLVVQIAQTYDMKHEEERERVTKPLKTPSSFDETMLDRKRQRVTYRGKSSRKSAKEMMRDLVASQMAALGQVPGWNLIHEPETETRSRCRDGDNQSQQRKQDEMYVPPAFYFPTFSSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WE95</accession>
    <name>A0A6G0WE95_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ALA-interacting subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_016401</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CDC50/LEM3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000253">
        <property type="protein sequence ID" value="KAF0725003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WE95"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021354"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005045">
        <property type="entry name" value="CDC50/LEM3_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926:SF0">
        <property type="entry name" value="CDC50, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03381">
        <property type="entry name" value="CDC50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015840">
        <property type="entry name" value="DUF284_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="139"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0725003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="402" mass="45235" checksum="8701F1DD05746917" modified="2020-08-12" version="1">MEEKSKRPDDTPFKQQKLKAWQPILTPNWVIGTFFVVGLIFIPIGIILRIESDNVVEYSIQYDGEGRLEVNAHDPVVSISPVNGTMGCALGDAEGNTFNLNKHGCVLRFKLDKYMKAPVFVYYQLDNFYQNHRRYVASRSDEQLRGSQPNSLSDCDPLQTSPDNTPKYKDLTDTVGVNGTWNLNPCGLIANSLFNDIFWINGVRLPGGAYLSQTDTFPGTSNEVVNLMNQSGIAWKSDIDSKFENIKEADRKANEMYLWQNPNYRYIIPSAAGLPRILNKTAWTTTTNANFGVKSEHFIVWMRTAGLPNFRKLYGRIDTDLAAGTTLEFLVSSNFVVSAFEGKKSLVLSTTSWFGGRNPFLGVAYITVGSLCMVLSILFFAKHKLSPRKLGDTRYLVWKNNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WER6</accession>
    <name>A0A6G0WER6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_016596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000261">
        <property type="protein sequence ID" value="KAF0724847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WER6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005577"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="64"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0724847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="184" mass="20630" checksum="56042A57637DA1CC" modified="2020-08-12" version="1">MRVRFTPVVPEEVKKANEKSRRARAQDKRKAVRLLISLFKAIPPRQLFSLRDARKRGCYGATKPIVVTGPSKIERAGAGVFACVDLLPGDVVTTYDGQVVLQVPQEPSYAIRYDFGATPAWIDGLREFQNGKGVGSFVNRADREAHFYKNCDYIQDGNTLAIKITKRVKAGEELFTTCGRSYRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WHE1</accession>
    <name>A0A6G0WHE1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Disease resistance R13L4/SHOC-2-like LRR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_015226</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000213">
        <property type="protein sequence ID" value="KAF0726605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WHE1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000810"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="3">
        <location>
            <begin position="150"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0726605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="329" mass="36967" checksum="9A7191FC04444A3C" modified="2020-08-12" version="1">MSDDEDASGGDSPSLLKDFCEKYDIDIDGGDEELEEIDLSEKDLETVPDELFAIPQLQSSLRTLCLEKNQLKSLPQAIGDLRHISELYLRENQIDRLPIALAQLKHLDSLYLEDNVLTEQGFPDALTALAKLKGLCLQRNKLTKIPMPIFSLVGLEELYLDSNTIEELPAEIGALVNLKELDMPNNRLRTLPKSFVQLSRLEILHLEGNCLEKLPKDLGSLESLKKVYLQDNALEKLHASLGRCTRLEVINIENNKLNKVAKRIGDLPRLKHLLLAGNLLESLPFNPFEKMGALRRLTLSGNKLSPDMMMLESGMQSTVIAEDDEEKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WI31</accession>
    <name>A0A6G0WI31_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_014980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000205">
        <property type="protein sequence ID" value="KAF0726837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WI31"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013596"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="1">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0726837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="482" mass="53123" checksum="AFD89FE2580636F9" modified="2020-08-12" version="1">MNVTSADIDTSRPYTCEVNVDDVRVLQKAEYEVKVRCTFFSESLRSKCMATWSVWRSFSAFRLLDAQLRKRSPTHMKGIKFPPLHRQRTLFRTHLDPQFLEARRADLDTYMSMVTAAPAFVTFHITSIEAQSLKSFLSYTGGFGQNITLVPSSADGRHSTFLERPKPAPTSQSLTASYRWSGTGFIGGQHLKGGNSIVMRNSSSSSFVPVAPQQFNQNYAERQSFAQRNIPLSAPTRQSVPTEEESPPLMAVTVPDVVDPVVEQERGKMELELRSAGLQGVGMPPDGSCFLHCLIYELLPLKWPCFAEYPAAMAMVNVGSADGVAPRRIKAAAKLRTELSAFGLDNVDALSTFLLTPRDELVERYTLFGSRSDEQATVAELYAAASMFDLEIVLITNDSAFHIDPVVPVTGVPSIRGPASYRRTIVLGYMPPNPKMGGHYICTREISYSNSFASGCFSGKMSSMSSRSSMRSTMSNSLGMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WI56</accession>
    <name>A0A6G0WI56_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Small nuclear ribonucleoprotein G</fullName>
            <shortName evidence="9">snRNP-G</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_015025</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Plays a role in pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000205">
        <property type="protein sequence ID" value="KAF0726883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WI56"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004796"/>
    <dbReference type="OrthoDB" id="2146at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034719">
        <property type="term" value="C:SMN-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097526">
        <property type="term" value="C:spliceosomal tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01719">
        <property type="entry name" value="Sm_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000023">
        <property type="entry name" value="Small nuclear ribonucleoprotein G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034098">
        <property type="entry name" value="Sm_G"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF2">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037188">
        <property type="entry name" value="U6_snRNA_Lsm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="4"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0726883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="76" mass="8604" checksum="1BBC3718B85A6F2E" modified="2020-08-12" version="1">MSKVTGPDLKRYMDKTLNIKLNGNRKVSGILRGFDQFMNITLDEAIEEVSQTEANKIGMVVIRGNSIVQFECLDRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WIL8</accession>
    <name>A0A6G0WIL8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_014805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000202">
        <property type="protein sequence ID" value="KAF0727066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WIL8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001526"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0727066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="282" mass="33333" checksum="F0A56CEAC63C159D" modified="2020-08-12" version="1">MDKQGIGRKDGSTTDAPPVKPSSRPQQQTSLSSSEPPENDEKRRLAVKRYSATYRTKNREILRQKNREWKAQNKERLAVQKAAYREKNRERIRVHDREYYNKKKGRTVEPTAQTMTPTIQPCNPSSEAELPETSNTKITQKPPSSLQIESLPRETANTQQTHEEIPVQDPPQSQSPSKATKHPTRKRDKDKQAQYDMAYRQRNKAKLAEKSREYYVKHKDRVLAYKERNRDKILATTRDWKQRNKDHVQAQRKKYRQANIERIREHDRQMYQLKKSKPFVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WIW4</accession>
    <name>A0A6G0WIW4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_014773</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000201">
        <property type="protein sequence ID" value="KAF0727136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WIW4"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0727136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="105" mass="11904" checksum="1B6ADD1819290F9E" modified="2020-08-12" version="1">MSQWVGFFAKEHQRYRVFIVLTWHAICRIPWGFFKLLFGLLDCCVGAVKVPRLRDESLDEKRESSAVITADLGTCVVNTAIEAAWNHSEQEKGLICLQFAPASCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WMW1</accession>
    <name>A0A6G0WMW1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">OBG-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_013638</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000175">
        <property type="protein sequence ID" value="KAF0728680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WMW1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002586"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01899">
        <property type="entry name" value="Ygr210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.470:FF:000001">
        <property type="entry name" value="GTP-binding protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013646">
        <property type="entry name" value="YGR210-like_G4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF1">
        <property type="entry name" value="OBG-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08438">
        <property type="entry name" value="YGR210-like_G4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="4">
        <location>
            <begin position="3"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="411"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="421"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0728680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="437" mass="47497" checksum="3CC0E4DE9D1A76D3" modified="2020-08-12" version="1">MELAIGCVGKPSAGKSTFFNAVTDGKAKVGNFPFTTIEPNEGITYYMTDCPCKSRGKSDVCKPRYGQCANGTRHIPVKLLDVAGLIPGASEGAGLGNKFLDDLRHAHVLMHIIDVSGTTNEKGEATVGYNPLNDADWLTMEIHNWVYNNLWRRWGSIARRHTATQSSLRATFQAQLSGYGATSSTILAMLNGMGEQAKEPCVLSSWGEPEVHCLVDAFLAHRFPTILVLNKADIGADTDKNIEQVVDKYGSDRCFVASAASEVFLRNMHSKGHIIYEPGDMVYTTHEDDASLKPLLPKMSARLDQVSDMVLFRYGSTGVRAAINAAVELANMVVVYPVKSLKNFTTVEGDVFGHAILVRQGTTVREVAYVLSPVVGANYLYAEGEDGRRLSEEEPATNNLIVKFTTVVSKEAAAAAPPPPTEEKKPKKEKKADAPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WMZ5</accession>
    <name>A0A6G0WMZ5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_013639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000175">
        <property type="protein sequence ID" value="KAF0728681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002585"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021067">
        <property type="entry name" value="Glycosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34496">
        <property type="entry name" value="GLCNAC TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34496:SF6">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11397">
        <property type="entry name" value="GlcNAc"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0728681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1900" mass="217684" checksum="DADFDC1B47C38DDA" modified="2020-08-12" version="1">MQGRQRPKRRHSPGWLDPMNILIASLVFVLCLMIYMNVSMMGMNQDESSTLHSKKWSQSFRQAPDSAKALNSRRTIVLIANYRDTKRCSETLNSIFSQADHPELISVSIFDQLNFDENEKRCFDAYCDLVGEDKCRRSERLRRNDTVSCKDAKGPTYGRYQTEEGVDLSIDTFALAIDSHLIFIPHWDTDLISQWDATGNPKAIITVYPDATEQMPKNGEKPTGTILLCHGRIENAQPDSMVQYSSAVRINSPDKPMLMSQFAGGFNFGSAQSALEVRNDPYAHYLFHGEEYSRVARLWTSGYDTYIPTHMLCYHWYEKRKGMWDEDWGAKTVIARRSQRRIRAALGLVPTLDDYDRTDLHKFTLGTKRSFEQFKKFSGIDPDASWIEDNEHQFDVCPPKELKYVPYLEEPAKIPTFTPPKQVPALTTLPVTQTTTTAVQNPPTAAAVQNLPTTAAVKTTLVNVPATRDPVNRRIIVLIANYRDSRRCGETLRSMYSNATHPELISVSIFDQLNFDEGEKPCFDVYCSLVSDCRRSERLRRNASISYLNATGPTYGRYQTEEGIDLNIDTFAMAIDSHIIFIPNWDADLLSQWDSIGNPKAIITVYPDSTELYPKPGDVQTGVTLMCHARIESKEKDAMVQYSWAITVPCPQKPQLMSQFAGGFNFGSAESALEVRNDPYTPYLFHGEEYSRIARLFTHGYDTYIPTHMVCYHYYETRKAIWDQDWGKKLMIAKQSKRRVRAALGLKPSNDDYDKTDLAKFSIGTKRTMEQFRAFSGINPDASWIEDNEGQFDVCPPKELKYVPYEGSPVETPPPTLAPLLEVPTKPRTRDPVNRRTIVLIANYRDTKRCSETIQSIYTQADHPELISVSIFDQLNFDENEKRCFDAYCDLVGEENCHRSERLRRNDTISYKDAKGPTYGRYQTEEGVDLSIDTFAMAIDSHLIFIPHWDTDLISQWDAIKNPKGIITVYPDATEQMPKNGQKPTGTILLCHARIQYNQSDSMVQYSSAVRIDSPEKPMLMSQFAGGFNFGSAESALEVRNDPYAHYLFHGEEYSRVARLWTSGYDTYIPTHMLCYHWYEKRKGMWDEDWHIKEVIARRSQRRIRAALGLVPTIDDYDKTELHKFSLGTKRTFEQFKKFTGIDPDASWIEDNEHQFDVCPPKQLKYVPYEGSPVETPAVTVREAVAPTLPRTRDTVNRHILTMIANYRDSTRCAETLESLFSKAARPELVTVSIFDQLSLEEGEKPCFDVYCEKIGEANCKRAERLRRNATISYKDAKGPTYGRHQTEEGIDKTIDTFAMAIDAHLIFIDNWDTDIVSQWDSIENPKAVITVYPDHTDMFPKNGKQAEDVLLMCHARIENNGDDAMVQYSSVIRIPCPTKPQLMSQFAGGFNFGTVEYALDIRNDPYTPFLFHGEEYSRAARLFTHGYDTYIPKHMIAYHYYEKRKVFWDENWDVKYLVAKSSQRRIRAALGLPTTVNDYDKTDLEKYSIGKVRTMEQFKAFSGIDPTAAFMEGKNEAQFDVCPPKVLEYVPYEGSPAKLASPAPQAVAAPTIPRTRDPINRHIIVLIANYRDTKRCSETLESIYTQADHPELIAVSIFDQLNFDENEKRCFDAYCDLVGEDKCRRSERLRRNDTISYKDAKGPTYGRYQTEEGVDLSIDTFAMAIDSHLIFIPHWDTDLVSQWDTIGNPKAIITVYPDATEQMPKNGQKPTGTILLCHGRIENNQPDSMVQYSSAVRMDSPEKPMLMSQFAGGFNFGSAESALEVRNDPYAHYLFHGEEYSRVARLWTSGYDTYIPTHMLCYHWYEKRKGMWDEDWGAKTIIAKRSQRRIRASLGLVPSNDDYDKTDLDKFTLGTKRTFEQFKQFSGINPDASWIEDNEHQFDVCPPKELKYVPPKENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WNQ6</accession>
    <name>A0A6G0WNQ6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_013306</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000170">
        <property type="protein sequence ID" value="KAF0729006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WNQ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006544"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0729006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="324" mass="36340" checksum="EF8327A74C27326D" modified="2020-08-12" version="1">MVEARLLATVAAHDKPVFKAQLPRYSVTHSNKPNCTMDHPIESANACLKKHAMSTEYTRCVNEHCHPPSEDDLPVPRCPATYRITTCSITLQSIFYLLGTHLGEGNAAIPLAAKVTEQMKTDISSKITADPMVLPKAIYKLIKARCAAGMYDDALCPTFKQVQNYIQYMRSRDCRLKSTVPSVRTELEMWRLNDNIGEQDPNKAFVFGVPYMSGEFQLGDGGLTSFRLGLTTVALMAKYRRVVESNPGRVVLCHMDTTFSTNLSGYPVFVFGYSDFCGSFHLLCICITSTRTHEDVVWLFKKLKATFMQVLNFRTIPTSTSIDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WP30</accession>
    <name>A0A6G0WP30_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_013109</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endomembrane system</location>
            <topology evidence="10">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MNN1/MNT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000167">
        <property type="protein sequence ID" value="KAF0729131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WP30"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012093"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046354">
        <property type="term" value="P:mannan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646:SF1">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026223348" evidence="11">
        <location>
            <begin position="23"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0729131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="508" mass="58943" checksum="DADB25C867ADB1E8" modified="2020-08-12" version="1">MALLPVLLFACSAFVLVSLQLAWRMHNIETPEPLRTSVISHSPDRRLVLSPDISSQAQNAVIRGELPEWRRDFRRDNYTCLGWTPAVDCAPDAAAKPFWQRFECNTEIQPGTPGFCEIKHLTTGEIHRLYTNCDGIRKPFKCNQALNYYEYAADANRYVYTHRPSVKAQNLRGWDTSRGIVMSLYPEALPSGYAAIRRLRAVGCTLPIEIWIIQEELTATHPVLYYLTSKFNAIVRYIEDKSARKFYVKPYCIYHSMFDQVLFLDADNFAARDPTYLFSHPAFEATGAMFWPDYWQPNNTIFGLMDRSLLWNMLGIPYVDMFEQESGQLLIDRKKSSAQLEMLMYFSFRIPRLINDYDFIWGDKDLFRFAWMKTNKPFYMIQKPSGSAGLKHKDYDLFCGHSMVQHDPEGKILFLHRNTYKLTGELAAPFIWTHIQDFRGMTADENYIIRFAFGGQAFVGFKCFGNDTHYTDHFDMRPFSSYEELENIELSLNSWALEAVQLSGFVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WS17</accession>
    <name>A0A6G0WS17_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_012218</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000155">
        <property type="protein sequence ID" value="KAF0730215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WS17"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019209"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.10.10:FF:000007">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="10">
        <location>
            <begin position="336"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0730215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="652" mass="72282" checksum="4F81E87BB9E99F30" modified="2020-08-12" version="1">MKATILIDTGATSSFVSATFWHKLGCLTLSYPRSSFVSADNSQLEMLGRIKLTINLAGRKVLFPFWVMSTALTDCIVGIKLLRQMGAIINLNDNTLSIDGCDELISLSPLSPAQQETHPTGPATVATATQIPPRSFQWITCSAGSDLPTSTTILVEPANSALLHAAAALYRTNPSRTVLLEVANPSDSPIHLPAHAILGTWMALPKDHLESTIDSNDSRTQPDNGQSSQTTDEPRRVLTQIGGPGVVCPVQSETAPTKELPIDWTESSLSIDQRELLRKTLMKFSDIFVDSSKAPGRTHLIEFSIDTGNNPPIRSVPYRTSKAEGDIMEAELNQYLDLGLIRPSKSPWSSPVLMIRKPDGSIRFCIDYRKLNSVTVKDSYPMPRIDDLLDVLGRAKLFSTMDIATGYWNVPMAKDSIEKTAFTCKYGLYEWLVMPFGLCNAVPCFERLMEHILIDYKWRTCLVYLDDCIVYSEDFGSHLIRLSQVLTKFREAGFKLKMSKCKWGRSSVPFLGHIVTPAGILPNPEKIKSVLRVKPLKDASEVRAFLGLAGYFRRFVRDFSKLAAPLTNLLTAEQFIWSTACDEALESLKRSLVSPPILAHPDFDLPFSIWVDASHIAVGAVLMQKQQNKNRVIAYASQSLTKAQQKWISGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WSH4</accession>
    <name>A0A6G0WSH4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_012133</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000154">
        <property type="protein sequence ID" value="KAF0730433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WSH4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015957"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0730433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="377" mass="42605" checksum="F1E8FDF65DE259B8" modified="2020-08-12" version="1">MLAPIPLDVAITTIRANSLYENIFTISGHCWVDFDRRFEMAHTAKRQLRCALRQNDNAAVYLEALLRNVITVDLTQSAYGLQMNQIILTAVATTPEGSIWVSKLRNHTWSSVADEVSVWSEHGLLRYNIQWHNRFQTGIFNSIKIVNALGVSRSVTTRYVPFVIRGLAMWSSRHISSGLWNDMAKCVNLKCTMVRNMNNSMEAIGHDWDALYMGSTQTTGRDLALSFIGPLMNWDTFFVAPPASLFNLVASFQRMLNNRLQNDDAFCDEYQPLFEVDIDVVPPHWDSPDMLYYGGNPLCAPLAAAKPFVQMPFTYDDACLTQNRLAITFTRRGLLFSAWIMQQANMNANSVCSCSVLSRKNCYDAILPALRLVSSFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WVT8</accession>
    <name>A0A6G0WVT8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_011254</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PIEZO (TC 1.A.75) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000141">
        <property type="protein sequence ID" value="KAF0731636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002400"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071260">
        <property type="term" value="P:cellular response to mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050982">
        <property type="term" value="P:detection of mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027272">
        <property type="entry name" value="Piezo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031334">
        <property type="entry name" value="Piezo_cap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056770">
        <property type="entry name" value="Piezo_THU9_anchor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056769">
        <property type="entry name" value="Piezo_TM1-24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056768">
        <property type="entry name" value="THU_Piezo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13167">
        <property type="entry name" value="PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13167:SF25">
        <property type="entry name" value="PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12166">
        <property type="entry name" value="Piezo_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24874">
        <property type="entry name" value="Piezo_THU9_anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24871">
        <property type="entry name" value="Piezo_TM1-24"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23188">
        <property type="entry name" value="THU_Piezo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="519"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="559"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="638"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="669"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="694"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="749"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="806"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="838"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="869"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="926"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1021"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1180"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1217"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1273"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1347"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1372"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1408"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1922"/>
            <end position="1949"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1961"/>
            <end position="1981"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="2302"/>
            <end position="2321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="2341"/>
            <end position="2360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="2372"/>
            <end position="2392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="2404"/>
            <end position="2424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="2524"/>
            <end position="2545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="2810"/>
            <end position="2830"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="9">
        <location>
            <begin position="1566"/>
            <end position="1667"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="8">
        <location>
            <begin position="1701"/>
            <end position="1798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1128"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1825"/>
            <end position="1855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2162"/>
            <end position="2241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="2181"/>
            <end position="2194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="2220"/>
            <end position="2241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0731636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2910" mass="331215" checksum="6A81D3CDF0D4C03D" modified="2020-08-12" version="1">MATLLIDPDSTRSSAPGETTYRDAKTPPNQSAILDGGDYIVALSTAPRPSSTAKHSHATAREKAKFWSKRTLMKVVWFLADVVFSFSLLLATAVRGSVLSSLYLAAWIIGILYTFKSRLLTVFTLFVAICGVGGNIFSIVWYKSKLKGAALAPGQSIEDVSPLPGKEILSIMGINYMVTWDEYLLGIGPDALIFLSSIIHLYLLKKQFLKAHGKSQDLVASSSHHEHAQDGNNSVEESYFSKEALIIIIGGSEVIALIALFLCALSSPGVLCGAYFLIFLYCLIVWTVKSPRITRRQLENGESTFCYFFGPSSMRFLVTLTIPVLLFCHAFQYPRFHDSEFGRKVGKYANIFVLPGSWDNWPGYVFYGAQLFLLATASRTCPIYKQLASLPVEESTHDEPIPQRRQSLAETLYHEPLSSPTHSLRQRRWTGERANNASTRTSFYSAHESSSSFTKLSAKELLSRESLIVRIFLEDRGVLGAIVAALFWSVSYPSYLMSILFGVALLTLGSYGLVIPRMLLIVLSSYAVFSACVVYLFNIPALAERSWVSDLVDELRLGISVYPLIDLAIQNACLFVMCFCLRIRLRYRDLLQELREEKALQLLNQEVRISVLSDMSATSSQVQQEHIQMHRMKFVEILALWFKDLQCVFVSLLDTLVLFTIFVTVLSTSVNLLQTGYLVLAAFLSVFKRLRRRLWRWLLSYALAVCFLIYMWNVICPTRFDSVKTDTWGLTCFAGPGVKGDRPSGWEKLWPTLFTAQLILILQAVIQLVIYMRSDAGRAEREAMLAQAPGRPVFFISRITLEIDMVFRFVGGIVTYVGFLLLGFIYEVDSSGRVTLFGLLQVFLMFTLLGSHMASMIKSPRGNSTKTQFLWRVVLVYEVLVLVVRYIYQFEAVATYIHEKWHLDKFMTLEDVGLHRHSATTKLSGLFVYLLPTAVLAALTAWNLRSMKRKLPLYEILPPGRSRFIDAIIVIVKELKRMVFVNSPIVLLVFNMAIVCRNINAFNVTYLTILITTLFKPKWTGSWKSLFWLSSFFILCLYAFQFRSLQPDRLELLFGPEHAKSFEDNASWIGLARVNKTMAELMEGKSNNPDTANGGNYYHSSIWSMTWEHMVVMLLCLVTRASQFWDPEKDAKPNSKKQRPRKPSEWHASSSNMSEDTPFLKSVQDFLIRFASEGSVTLTMLMLLVSAFIHLNVISVMYLLVVRWIMVSHPITVCRNWNYLVIMLLFVCVTQYFIMLWFPPFLDWPRNTTVPWKWLEHHDEYAEYLALNFQHPMGLFSDYCCILFVFMIPGAKPYYLEIEKRTMAAELAAHETDSGQNHRDTLTASVVPGDANDFTTNAKENQQPWRLLVFMVMNYWVFVLLIMVFVSGCIRSGVASGIYLAFAIYMLVNVNDVDSPESKMLSRLREFSWGYMFLLVLFQTPVFGNPTEYCTLGTHVNGKVCLSAPAVLDLNKFPKNYPSAPDVGATVPVLSIVIFWMINIQELIYQSPLYDYVRAFTSRESDQSQRRCRALHEEVLMDRLERWQALKHEKQAAILRLKSIISRMVNKVEEMMDIASGLNYSLPPSAPQPPTIVTEETTQNSVTLVWNAPESPLHRIRSYTITRQVYPPTTLLGDYSYPIEVKASLGTRFVVDGLRPGTTYQFKVAASSRMGEGPFSAPSVPIQTFPLNWGGTCVAGWVYYRKCLWPQPWYSKLWTPKELPRYAVVDSHAFVWYKNEALALKHRSMKKRKRMKTSFLTKDVSVFDLSEQTYRANEMSDEMYALQIVATARNSHQVRYTVLLETQQQFNHWVSDLSQLVPRHAIGPRLEAYLDANGISLPPIPESSMFDDEDENFNGPRSEWSSVTGDESWLNDAEDEEQSESKNFVGLAYLAFYNFFYMLQDISLRHEEQIYEEDDEQLPSWFELFTVMLNALRSHTRNLCCIIFICSFVSQGDILNMVYVFAAFGFLLLENPRPHSYAWNLIMRYSFWVVFARYFFQLPVFCQNINSDSVLYPSMQPWCPDSLFRLKNRNPIQPMVYFGLYKFDGIANPLVDTMWKGVAWNFVVILSILFHRRELQLRGLWLNVDTEEDSPNLLDRQRTTVMSRDSLDDPELYDVAAFLARHKDDTVKATPGDFHVREMPQSRPAALSKVVAFEGTPDDVARDDDHPRQVTSPREALLQTQLSTQLSRDHHWSGSQNDSTHNAHSDEEETRVVDPRAISPREALLRAQSRMSASPRVSMMSESPRSLREGSSGQLEQNETQPLLEFVDQVPTIPKKPSKVMIWLESTFPSTMAFLARLWPTVPEHWDKDISEAMCSKPGRDYFAAMVLIPFICIIYAFLFFKYFGEPVDDSETFSINLSDSMLNGYMVLIIFFELIVIIWDRAAFVCSSLRIKVALHFTVLIGVHLGLWLMLPLSSKSYFQSRVGLQGFYVLHCIYLWISSYQIKFGYQVFRSNHHNKKSVEEQSWTHELYGKGFKVFMALPFAFEIRCLLDWMCSKTALNKDMWLLLEETAATLFLVRHEMDERIRDAVYLKGNKRHPVYKKFLTGGFILFVLLFCVIAPLAMFSSLNPSTQENSVKTVTVKFGLLQGDGTLQEFYTNGDSNGPRYGGLKIKATDTFIQKNSFSSYSKDLWISSPPLRRELVNRLRSSESLKWSLRVSFSRDGPQGNQDVTKSFEQSLTALDRTSLISLVQGTNVAAATPASSSSILGSNASMATALGSNLTSVSLASDDIIVAPNAIRIKSFFNPVLKVPASSAVTPRTNYAKRDLSIQRNIEDGVSWWVINSTDASNRPGENDGLPINCQESPEDKDGFCLITVSDNIVSGLTKLGIGSYGLTAAYIFVVFTVGAFFKEMLRGEMYKVLYNELPNPNDLLDLVEGIYIARKEEYIGHLKDEGRLYETLVRMLRSPETLIKLTGSNAIHIPPPKHKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WWM4</accession>
    <name>A0A6G0WWM4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MIF4G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_010973</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000139">
        <property type="protein sequence ID" value="KAF0731875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WWM4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013959"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039762">
        <property type="entry name" value="Nmd2/UPF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007193">
        <property type="entry name" value="Upf2/Nmd2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12839">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 2 UP-FRAMESHIFT SUPPRESSOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12839:SF7">
        <property type="entry name" value="REGULATOR OF NONSENSE TRANSCRIPTS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04050">
        <property type="entry name" value="Upf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G" evidence="4">
        <location>
            <begin position="36"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="MIF4G" evidence="4">
        <location>
            <begin position="446"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="MIF4G" evidence="4">
        <location>
            <begin position="650"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="390"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="921"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1061"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1096"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1155"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="414"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="924"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1072"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1106"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1124"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1177"/>
            <end position="1187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0731875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1187" mass="134234" checksum="6CAC6BD0A0BF0CB3" modified="2020-08-12" version="1">MQESLRETLRQQNSPEACADVQKAISSGKFKLKSDLKKSSTLVKKLKGLGDANLAACLKDVGELNLTRYLSECVVSLVEAAGTLKPSEVSSHIQVISVLHQRYGYTEITEPLIQAYTTAFMPPPTTTPPAPPVDAATKQRQIKRRLVTLRILTELYMVGVLRDVSVIYNILHCVVTREDLTAKPSKKQQTATPANTKQLPLDVPLLVSFAKYAGSDFLGGKDNGDASASSITVPPAMQAQFRALFEQAFDMIATLYIAQHQTVRKLEKRNMKEEVNRGELSEEHVADLTAATALCEKLTASITTLSETLQKPIPSLPVDNSDDARLAQLLLWDGGEGRAELHADGPFDDEDTRSFYEDLPDLLELVPAVVLGLTEAEVAELKLKKAALAVEEEKESQDDIPDEPIVDEIDEGEDKNPDSEAPGPKEVETTEEAGDKPTQSYHHQTDAFFASLEDMISRDRCDKAAVDFCYRNTKAARTRLVNTLYSVPRTHLELLPYYSRLIATLDSVLKDNVGGALVDLLVQEFNYFQKKKNQYRLESKVKNIRFLGELTKFKLAPPVVGFRCLRRCFADFQGHNVVIATTFLETCGRFLYCSKFTHVRTAQCLEIMMRLKAAKHLDPLSDTLVQNAYYMCKPPERVARVKAPHDPIYLFMLHLLYTDLNHENVGKVVRICRKFDWDDPRTMNWFIKAALKVTMSQVLQMSLVCDVITGLSRYHEDLTIFIVDSVIESILYHLDMNNYKYHQRNLGLVKLLGEFYNHQLVNSVVVFDILYWIIHHSHDMTKMKTDTPLTDEMQRRFELVPDMKFDPRVPSEVDNDRNVFRIRLVCALLETCGTSFDRGITKKKLERFLVFFQRYLLSKAEIPLETEFVVLDLFEVLGAKDKIVRFDTWEQADAAAQGIWGVELQQAERRLLKTKVSNTLQIPEEYDEDDADEDEDNFSSEDEAEDAVAGDDDDDEEDEDAATSSEEEDDEDEEDEEEEQIIVKNQPKQEEDEEFDRAFKSMMQGSLESRKHIPRVNVDKMAIPTVVKTTHHLDQVNDSSVVFRLLKRGNKGKLEAREIMVPQETSLAQHSQRQEDAGKKEQSELKRLVLLNVERDEMNYEDDGPSSLTLQSNHTSRNYEKPQRQNNNPNSYIVANPTGRGATWGSLDSFLETKKTSLVGPPVQVANRGGRGGTNTSGGRSYRGSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WWN3</accession>
    <name>A0A6G0WWN3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_010858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000138">
        <property type="protein sequence ID" value="KAF0731905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WWN3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004813"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="219"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="292"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0731905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="344" mass="39829" checksum="E594EE675E0807FD" modified="2020-08-12" version="1">MEVDDMTPILGDDKSEPVHDQVISQEYLDAVIRQVKFETEQQWKRTLADNEEKQRQLQLQVDILTSERDFLKENQAATKTVLDNFLQEYEAMQSHDKSIDELTVELQMERSARARLQEECFHLTEKKLAFAHQINMLQQQIVKYQQTETVLAQTVSHFQHQRDSRDIERIQELDRLKGEMDEASRAEVERAKEGHQQAAFSLELAQSESQARTFKCSLFKNLHRELEELRRRVDGHETQELVLRNLIQQLETDKAVLQSKSEQLQKTEAALRFKLNAAQHHARELQAKGGDANALNRQIAVLEKDNATLAQENAKLREKNTELNNIAVELVAQLESAQRPKADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WXN2</accession>
    <name>A0A6G0WXN2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peroxisomal membrane protein PEX16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_010611</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peroxin-16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000135">
        <property type="protein sequence ID" value="KAF0732322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WXN2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002007"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013919">
        <property type="entry name" value="Pex16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13299">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13299:SF0">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08610">
        <property type="entry name" value="Pex16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="2" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU365003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0732322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="333" mass="37534" checksum="14804BF77D37BB85" modified="2020-08-12" version="1">MIVQTPPTPVHHTLDKYNAWVLENESYARRLEQVLYVVPMLVPASVGHPDVVSEVGYSLGGLLKLYHDWILYEAQTPSDQKTSVKSLSVVQAARVPLSLISQVQVAAEMIALKTRGVQTRWNVILLLEICKCICKLVLLVQSKGKVLYKNGPYVSCEVRPKDESTEVYTGQRSGRVFLANRSESTNMQPLTLSFLEPNYASGEEGPIQTAAEVLHIIRPVVFAALCQQQSERSWVPFLASFSTEIAGILLSTLLEVKRKRPHNEKVDEEYHRRKMCLFLYLLRNPLFSSVTTPVAEGVCNSTQPIPILGRLIRFAVDNGLQYYQRRHFYTSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WYH1</accession>
    <name>A0A6G0WYH1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_010338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000130">
        <property type="protein sequence ID" value="KAF0732630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WYH1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019929"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF37">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="132"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0732630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="260" mass="29415" checksum="BE8293DCEF1FB000" modified="2020-08-12" version="1">MQCATPDLSGRLDTNGDTLRLARRAAVETILLDKVHDAEVHNGLTNQDAGRLREMLLRYADVFREDVEGDPPVKVEPIKVRLKPGSVPVKCSMRRYPPAHMDFLKRHVEQLERAGLVYKNNRATWASAPRIVPKKDPGDLRMTIDSQPINACTEPMSWPMPNLDSAMTILVGTTVYFTLNWTKGYWQLPLHPDSQMYYSFMTPWGVYTPTRVLMGQTDAVAYCQSVVHELFGDLLFRRLLAWLDDLLGAAATPGELFDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WZ36</accession>
    <name>A0A6G0WZ36_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_010120</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000128">
        <property type="protein sequence ID" value="KAF0732789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WZ36"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015238"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF37">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE 5-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="435"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="93"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0732789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="474" mass="53231" checksum="7BCDBEB8D1D7E21B" modified="2020-08-12" version="1">MAGFDLFRKVPDDLKTTSVSSGVFTLVTIFVMLYLIVAEFLGYVTSGNNLVSSVVLDSHQEDLLRINFNLSLPAIPCRHLSIDLSDHMGLQFSNITRHIRRVSLVQNTEGQLVRHKEVFMSEQVASWGNVAHTLHEGETITPLLNVQTFDEHMAKYDLVLVNYYAPWCPYSQALLPIWEATALQLQDHPEYAERVTMARVDCTQDNAVGLCRRARIMAFPSMMIYMFGRTFTRYIYNGPRNPESLLLFLDLFYRRLNPDGDLAEEVLPDFGDQLAVADTEEDDANEGCEVSGSLSVQRVPGKLSFTAASPDTSFDLQNINATHLVHHFSFGQFKTAEQRLAQAPTGVLAKHYPMDGRGFSAENSNITIEHYIKIVGVDRVDNSGMFDDRMEREYEFSVSSNQYNASNDMPAALFTYDVSPLVIELRPHSVPFFRFLTSFFAIVGGAYTVLKVVDAGVFLALNSIQKKAQLGKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WZ76</accession>
    <name>A0A6G0WZ76_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_010158</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000128">
        <property type="protein sequence ID" value="KAF0732829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WZ76"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001350"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0732829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="527" mass="58306" checksum="713C03202E0AE9AA" modified="2020-08-12" version="1">MRRLVHRVVHERVAWPNASTLRSLSTAVSSDIYAQKLQHHLLDSDFDTALQVFKAERTNVPPNLMAVMSIVEHLDKTDKARLIQKYTIAFFLKRQHQVAPTLVTAYKNLGISIPQPLLREVVLSLLHENETSRALEVIGMAFRDRVPISADIFYQCFSQCEELSIDPRPFAAMFIQFQKAQLVNFPGLPSLGSVILSVCFSQGAIADGLACVSLLPPSSVDSKKLQFLRQAFEVVDSTETTALHQTLIAFVQVEDDSKAWEAFSLLREKNIAMTSAFLKDIAAALFRLGRQDQANEVFAYALTQNIKMPALAFMLGFQKSRSLSLVAIYRDALRQNLAEPTGKVLSVAMRVAFEHSDSSLALDLKAIFDQQNFTSADKRLNATLEYVARSASHDQDIPPLVIDFVLNQRTSAAMPLFWRLVEAQIDIHGEMLQGMLNAAEAASNAEDLLTYAMKNGVALGTAAVVSSLARWPQDSLAAIAVDLIHANLVQVSPSLIRRINAAAAGDTYAASVALWDLLPRKEDKQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WZK3</accession>
    <name>A0A6G0WZK3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">VWFD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_010045</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000127">
        <property type="protein sequence ID" value="KAF0732936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WZK3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010716"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026352735" description="VWFD domain-containing protein" evidence="3">
        <location>
            <begin position="16"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1013"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="729"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="785"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="843"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="899"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="325"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="405"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="746"/>
            <end position="759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0732936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1069" mass="111189" checksum="6B47AA3F3FFE8577" modified="2020-08-12" version="1">MKAIVPLLMAALAVAQYRNDIGYSEQVGYGEEEASYGEEAAGYGEESEETEESSGYGSSGEESGYGVTQWESSASSEEYIAKLNADTDGFVTSLAQWVSDSTGVNFAVDSSFTLHTEGQEWSESCGDLSVHSAFKVLESFIENPKNAKKDIKQAAPLEWKPSKDCVKKHEYLFLDGGAHAEFKVYCGKEILVEAIAGGGGFYVPLCSGKSEYVGGALASVEIEHEIEVAGEVHAGKHLKTGLTKDRNHNAFNVLADLKETTQACANNGTLKVVGVAGGGWTQKYRKDGDIITSVVGYAESFSIIPENADESQIGGYGYDTEEPTEAPTPVPSSSEPLAEPTPAVTVPEIVGTPEPTEGEPDYGYSEETESPTTSPVVVDKLVDNNNTNTTTEDVIVAPAPTPAATVPAEVATPGPTQVEGDYDETEAPTTTIPVDKLVDNNTTNTTTEDVIVAPAPTPAATVPTEVATPEPTEGEPDYGYGEETDAPTTTIAVDNLIDINTTNTTTTTIDDVIVAPPTPAVTVPEEVATPEPTEGVADYGYGEETESPTTAIAVDNLVGTNSTNTTTDDVIVAPAPTPAATVPTEVATPGPTEGESDYGYGEETEAPTTTIAVDNLVGTNTTNTTADDVIVAPPTPAVTVPEEVATPGPTQGEVDYEEPTTTVPVDNLVGTNTTNTTIDDVIVAPPTSAVTVPDATSTPEPTEGAVDYGYGEETDVPTTLAVENLVDNNTTNTTTDDVIVSPAPTPAVTVPEAATPAPTQGEADYSDEPTTLAVDNLVDNNTTNTTSGNVIVAPPTPAVSVPDAASTPEPTEGSVDYGYSNETEVPTDAPTTLAVDNLVATNTTSTTSSDDIALPTPAPSEPKDATTPEPTIVAAGDYGYENVTDAPTDNLVDATSTANATDAIVSPPDAGYGEETTESGLGEETSEAGYGVDANATNTTEGAIDVTSSLVALSRRVSKSYLDAGIECAAMNPSSVCQSKRLASKLHLQLQRISYASIDMTSVYNPSSSTGKWSLTFETSAASLVMAACVILFVAIRTQRRRAGYVGIPQSSDVRPAQGGLDWPWYSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X019</accession>
    <name>A0A6G0X019_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_009986</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000126">
        <property type="protein sequence ID" value="KAF0733167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X019"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018605"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013714">
        <property type="entry name" value="Golgi_TVP15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28128">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28128:SF1">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="440"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="469"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="599"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="630"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="669"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="698"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="769"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="312"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0733167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="810" mass="88699" checksum="0987982B975E177D" modified="2020-08-12" version="1">MVRSKQWVLLGAPSAEKTALCKRLAEIFSLSYVSVDSEDLSVDTDALLAQLKQTQTDWILDSFPQTLDQATALKQDVNARPNLVFALRTAPAEEALEKIVKVFSCPVIYLDNLELDDDSLQAAIEDARKDPEWIDRLQAVPCLASDPSALLDISSVARKLPLERQTSAVTLLASLLRGEPRAFVADDTTSTMHAVDIYTRVEKPTQGVIAMNLAPELRAMLPFVEKLPPQALVTMAPLAHEIVQESRSGAITPATAVKVHQAFFQLSEKDRAQLVRVLPPEEKELATHVVEATEGLSPRGVETVVQLMLQTHDSQQQQQLPPRPNDYGTIASAREQPPHLPPDSVMTTLALAATKAHGRRLFRWVQSAPTSLRVLTFLSSALLLVTSIVALVLDLLSGQIAAVVVNAWIVFFALLLVSLEVKITAVEMHVSTAITAHFPLVATASGRGCFLLFVATLAVSLVAKASWQNALLCGAGVVAAVVALWSITLSSVASHQFNLLRTRIESLSELEKIFEQVVDDNDAANELDIDGLSRLCLHLKWPIDAAFLDTILRDLDLDNTNGVSLSDLQIWWSQTQIDTSVSIQMSMKAAIKPPSALKLVNWLAGVLVFTTGVVGNVVTLRTRSLGEATINVVVNLWLIVFGLLVVVLETPPSWLHLVMQLKLFMTEHFARFLDSIFGRALFYFFAGTVTISTYTADHLLPLFSGSALVLLSLVNSIVGKQAKAAFLALARTVNVSAIARIFADGDLDRDGVWSLEELDKFCTASGIQLSRPQWELLVDEMDRDHSGVISLHEFTTWVERQHPSAIDQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X0T1</accession>
    <name>A0A6G0X0T1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Centriolar satellite-associated tubulin polyglutamylase complex regulator 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_009627</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Regulator of the tubulin polyglutamylase complex (TPGC) that controls cytoskeletal organization, nuclear shape, and cilium disassembly by balancing microtubule and actin assembly. Regulates the assembly and stability of the TPGC and thereby modulates polyglutamylation of the microtubule, which antagonizes MAP4 binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriolar satellite</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CSTPP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000122">
        <property type="protein sequence ID" value="KAF0733378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X0T1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009092"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22959">
        <property type="entry name" value="DD_C11orf49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038968">
        <property type="entry name" value="CSTPP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34252:SF1">
        <property type="entry name" value="CENTRIOLAR SATELLITE-ASSOCIATED TUBULIN POLYGLUTAMYLASE COMPLEX REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34252">
        <property type="entry name" value="UPF0705 PROTEIN C11ORF49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="284"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="297"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0733378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="309" mass="35283" checksum="CD4C16B5CE8A3525" modified="2020-08-12" version="1">MATGHGSQGDGMSIFRARKNARNALLIHRDKTLDKLSTDDYLERTGVALFAEDALKQLMLDRPENAMRYFERYFVNVVMQTHVEGRKFDFVNANIRNRIAFVTYLEQTFNSVDENTELTVEDMHQLLAMRCQGFPRNIMSQATAHIDVSRGPKIHFRRLFTCFKGCFVYNEFLRYVHDVYGQVLQGDTKRALDAVEDQGSDRRRSSVLAAKFGEKIVMKLQAAYTSNSELFSMPPMSLLEVCVYTSVSFKQFCAAFLEHPAVEASIHDLQVSFDKIAECAFKSAKSGDDDGDTRKALTMKKRRMSKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X259</accession>
    <name>A0A6G0X259_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_009141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000118">
        <property type="protein sequence ID" value="KAF0733963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X259"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008280"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0733963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="642" mass="72979" checksum="8FD2530F2BC8DBEF" modified="2020-08-12" version="1">MKTSKRLANGAKSEDKERRRALSTPGRKKISAASVSPPRDSNATRFRMHVKEDTKHEAVVNNDASKLTKKQPTSASNSRDGLRGDESEVVPSNATLKNEELHVKRASADPSQRTAQARTLSMRTQTHPEASPSSKARIKVQKDLSTMKRLKSPNINKLRDADSKDAERVNDFQSAKMQKRKPKQQLHAKAKRNKIREQTRFNKVNKGLQSVHEDHIAKEEIEDFGSDSGDSDPRMALNQPLEEDWAWKMFDRHYFKPLATSSITQFEQIRAQQLCLVASNMDYMHGFTKSEVECIKRESMNSQTDPINIPNRGRFYKDIWEEEEYLEQLKTIAREMNCSDNVAKFTLHQDDSDLVSHYEVELFEQSLQRLESAELQQRSDTIDHPASWGKVWPCPVSEQIHPACWSKTPSDGAESDEISTAIQSCVKALIPQAMSNWQKMRDIYDRMLEEIELDPIFERERNLTSEIESYYQRWKQLKTPFHEKMTLSESRLASKIREYGANRAGAITFAAHFALTLQLGDGIDYLDHTGLWEPGYVVDIFVEGQSVLSHVKIQMSCQGSISQEWCCVYSGRIMPPGTSTLRTAPVLNVKIHPTHQNDTCVSVNHNVIVPVALKVAPMDGDITPLDALPTVKQLESVHHSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X2W9</accession>
    <name>A0A6G0X2W9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_009032</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000117">
        <property type="protein sequence ID" value="KAF0734164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X2W9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013928"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016462">
        <property type="term" value="F:pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04666">
        <property type="entry name" value="NUDIX_DIPP2_like_Nudt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047198">
        <property type="entry name" value="DDP-like_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629">
        <property type="entry name" value="DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629:SF0">
        <property type="entry name" value="DIPHOSPHOINOSITOL-POLYPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="5">
        <location>
            <begin position="24"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0734164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="161" mass="18226" checksum="BA44F6F341A7B0BB" modified="2020-08-12" version="1">MEIGDVAAIQTSRVGREKQRYDGQVRLIVCVVPLSESNQVLLISSSQRKDGWILPKGGWEDDETAEESVLRELQEEAGVEGIVMESLGEVNYASKNKSDCDKPSRLIGFTAQVTKEFKEWPESQRKRTWVDFEMARKLLEPRPELLAMLNRAVDRTGLNST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X3B2</accession>
    <name>A0A6G0X3B2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_008867</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000114">
        <property type="protein sequence ID" value="KAF0734407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X3B2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018433"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF463">
        <property type="entry name" value="REVERSE TRANSCRIPTASE TY1_COPIA-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retroviral polymerase SH3-like" evidence="3">
        <location>
            <begin position="96"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="274"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0734407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="824" mass="92593" checksum="6FB7C64EE0EB3E96" modified="2020-08-12" version="1">MDAYLKGNGIRKQTTQPHTSASNGEAENAIRTMANDARTFMMACDIPMSLWGYAFRHATYIRNRVPCKGNNDWESPLFKLTGKHPKVSHILPFGSNCTVHQAPQDKSITRRADLGIILGVNDEIKGYDVYLPQHNKVIATRDVRNITAPTPRRDVAEFLVGTSLPNASRLTNETNKSLSGKDNNLPKDHKKAKTVSKPDLTIRTRSQRAKEATAEIGACLNAQVAAYLAAETKHSVHMTIAEPKNVKEAMSSPEAKQWRDSMVKELEGIVGNGVLEIVLRPPATNVVDHKWVFKVVYDQKGNIDKFKSRLVARGFTQRYGVDYSKTFAPVIKQASVRLLFVLAAKYNCSVRHMDFPQAYLQAKSDHDIYFELPKELGVDTQKYVGKLIKSIYGLKQSGMLWNKEVNTALLKFGFSRSKLDPCIYFLWNDKGLTLCGLYVDDLLIFSQDDNVMRSLTEELTCKYKIKDLGEVKRCLGMNVHSVEGGFFLEQSNTIQELLVRHGMAQIKSQPTPIGVDHGFYDEGDESEMSQTELREIVGSLLWLAGSTRAYISVAVNMLARHVSNHNVNHERGAKRILRYLAGTMDVGLLLIPNTEKDIKSEIFCDADWAGNKTNRRSTSGCLMTVNGSSVAWYSKQQAVVALSTMEAEYIASSVGVQECLWIDQLMVELKLKNVAPTQLWNDNQSALKTMENDMAKSRAKHIDIRFHFIRDAVKSNKVRTGYCETGKMPADILTKPLSTELHMRRWPCTTAWTSARRPFGPIRSHPPGRLLVFFTSKYVASKSTSDEQFQVSQFPGHEFHSKLVTVNGRRLVHAVCQIVLECSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X3R6</accession>
    <name>A0A6G0X3R6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_008901</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000114">
        <property type="protein sequence ID" value="KAF0734441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X3R6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011027"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="379"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="269"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0734441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="464" mass="51532" checksum="2005FD789694E55E" modified="2020-08-12" version="1">MMERKTRINSAVHSGDETLLFGKDTVLMEWAKYLMETSISEMTMFQKLWAAWDFYGHNITIKVVTGITLAVLYLYVSGTQVIDLEQYDPVVVDHAVAAVALSCPVVYAIMLNMYYSDVETTVGLTLLTLRITCCCIVGAAMTVFLAEYFSRRIVLSLVLMGYGGWGFAYAWSVPIWRWYMYDVRQHGLVAYLPATLQDTLLRMTLLEWLTDTSFFDNMRQYFPFFLPLDASEQKRVVESLPSETQAMITKPGLINMLPPSVQEVLLPDPTATASSTSSTPSSSSTVVALDGRRDVQASSTVGFEFQKREALQSTAVVVPTTTASNDVITDIINNKISSTVMSIVHMPSPSMLNRTAAISSFLFALQLTQSQKARAHFVLLLRVLSMAVVGSVACAAVSLRVLQMVTSMPSSRKYVALIQDIWMRSQNQRRLTNGDGTTKAALESAAKYGLATIAVLWVVRKIRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X4K4</accession>
    <name>A0A6G0X4K4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HIG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_008582</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000104">
        <property type="protein sequence ID" value="KAF0734817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X4K4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017131"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040153">
        <property type="entry name" value="Rcf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28018">
        <property type="entry name" value="RESPIRATORY SUPERCOMPLEX FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28018:SF3">
        <property type="entry name" value="RESPIRATORY SUPERCOMPLEX FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="HIG1" evidence="6">
        <location>
            <begin position="124"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0734817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="214" mass="23169" checksum="DD429D05491E54B4" modified="2020-08-12" version="1">MQCSLGILGATNRTSHNSPILQFSNFKANQNMSAAAQLDKRDIIMSNSTSIGFKAGATAGVVAGAAVALANHNLPAFRNRLGVSGKVGLVVMASIASFTIAAEQDLLRGSRNPDEYINELQGAKTSNDARNTRHGQLPLHQRAANYVLDHPFRTVAFSAAPIVGGIYLYQQQNTNIQLSQKIMHTRIYGQGSSVVILLATMAFYDYMSRHGRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X663</accession>
    <name>A0A6G0X663_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_008142</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000099">
        <property type="protein sequence ID" value="KAF0735365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X663"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019755"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0735365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="251" mass="27982" checksum="5516B7943AE4BE28" modified="2020-08-12" version="1">MKSNSDDHATANGPPITCDICFGMTIYSSAMRDAKKPPMCIGLHGENMEVDNDGLAKDLDKAGFDQSLAQSELELASHPDMLNFMIEVQHMRAFSASITNRPFPLVNPALQDYVFVPKTDRFRYIFWGATVYISKPPSDDARMVLPLCQGYTWYLVKPKKSPAGQVTSEPLPPATSTLSKSQPDIPQVDILARAQTACSFTARAMITFTERHLSNFPEKYVHAMERLARGMYAQMENLAKLAHDFGSKRDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X6N9</accession>
    <name>A0A6G0X6N9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_007908</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000094">
        <property type="protein sequence ID" value="KAF0735588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X6N9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003052"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="entry name" value="Sodium:dicarboxylate symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42865">
        <property type="entry name" value="PROTON/GLUTAMATE-ASPARTATE SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42865:SF7">
        <property type="entry name" value="PROTON_GLUTAMATE-ASPARTATE SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00173">
        <property type="entry name" value="EDTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="Proton glutamate symport protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0769">Symport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="348"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="427"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="474"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="557"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0735588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="644" mass="70700" checksum="2F44E64DC0B67E61" modified="2020-08-12" version="1">MSTGSITLDSPIEGAPMMRAPHQDLGTAMNTRFQTLTHDPKTDMVILDGEPMHEFHPRHDEWFTWLWFVEGKWYKVLYLNVWGLLLAVVLGTLLAFVIEKCTSMDIDVNSNNATYIVEVVQDFTKNTRVRDNWSTWLRVPGDLFIRALQCIVVPFIFCAIMGGIGDLAKTQKAFGVCVRFFIYSIITATAAASLGVLLATSMPDQWFQPTIVLQSPPPPTTPAMAQPMVMPTSVYNMMQMTCPNKDLYLGLNQTTNLLQCMPSPKEMNFSLPTMTSSPPSTTTTKISSAVDEFYTFVLNFVPNSLMGSFQRSDGFLSISMIAIAMGVAMHLTDAAVAHSLVLELNKICLYMIGYIVKCAPVAVMFLVASSLLQAKIPDPSDTATSSSAISIDATDSAAVVQLYQWVLPLLRARSVSIFENLGHEAKLMGVLFVLFLIGLAVHSLIVLPLLVFLTVRRNPFEHVKTFSKAIGYGFGTGSSLVALPSLIQAAGASRVASRELSCTILSVGSAMHLDGAAFYFSTTLIFLMRTSGIALTNRNIAAVLVGSVVNSWSCPPLPHAGILVMMTLSINVVAPDLSLYLVWVVAMDVVMDRFSTVMSIWSNILILRVIASQTERETPEHGERSEAISDLEVFDDADVDYQYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X6V0</accession>
    <name>A0A6G0X6V0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_007753</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000093">
        <property type="protein sequence ID" value="KAF0735746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X6V0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014474"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052050">
        <property type="entry name" value="SecEffector_AnkRepeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586:SF3">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0735746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="328" mass="37039" checksum="35D1751911632D6B" modified="2020-08-12" version="1">MQADTAAVACCLLAPEILRCICQFQDGVDAYVVPLLEFHNEKRWTRLLHILPRIADVDDVLGPWYDLYGTRHVLDVLRLMPRLAVLLSTHALLLGNAEVVQLMDEHDYLDRNDPHHLFLAACNGQLDVVALLTEKNYAMTSQAMDMAAMNGFRQVVEYLHIHRTEGCTTQAMDLAAGNGHLDVVQFLHANRKEGCNKWAMNLAAAQGHLNVVMFLDHHRSEGCTTHAMDDAAKAGHLDVVRFLHKYRHEGCTTDAMDGAAENGYLNVVKFLDENRLEGCTRRARQRAIARGFNDIVAYLDSHVLIKDNTLSSDLHCPWRWRDYFGGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X6V7</accession>
    <name>A0A6G0X6V7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_007942</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000094">
        <property type="protein sequence ID" value="KAF0735623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X6V7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009870"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026115390" description="Secreted protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0735623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="20719" checksum="5B085FCF2CA30F28" modified="2020-08-12" version="1">MQLATLFLAALALLAAVDATIAQRADSNAIQTCTNTVQLIQSKALTNPAAVTCAKAVPEVAAGGDTSKGLSSLGKDAIPTATVAKLVASTDCASWYSSMASTIVSISPACDFTYGTSTLNTAKYNATFSVFLAAANTGTGTALSSTTTTTTATPTTTSATTAAPTTTSSTASKTTTQPTTTAAAAKPKSISAASTTMMANAALVVVAAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X789</accession>
    <name>A0A6G0X789_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_007845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000093">
        <property type="protein sequence ID" value="KAF0735841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X789"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006715"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007041"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0735841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="259" mass="29839" checksum="AC834CC6DAB63382" modified="2020-08-12" version="1">MVLGIFSLLATSSHYDLKANDSTTVVALPAWRQDDLLTYARHTNRVTDAGLAREPSLCKLVKEQYFFSGGSLGQFCKKRQELVDTVDICCNMRDHEQENCMFNLYVADPDKLSHYSTRSQWRLCIDSGYALTKLAKQVCTDNISQEYQFGTSIDAGFDRTAYKLYFHHRIYESLVKKKPVVIYMRDTRQSTIELRSFRAKYSDMVEMNLTATTIWKHLCGKTRTGEQTMFFSHLLTPLSSVKHLDTHVLALTRSLLIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X7E4</accession>
    <name>A0A6G0X7E4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="16">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Ae201684_007882</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="16"/>
    <dbReference type="EMBL" id="VJMJ01000093">
        <property type="protein sequence ID" value="KAF0735880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X7E4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003777"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02081">
        <property type="entry name" value="P-type_ATPase_Ca_PMCA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000014">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000033">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000036">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000029">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000045">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000144">
        <property type="entry name" value="copper-transporting ATPase 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF369">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 16" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 16" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13" id="KW-0186">Copper</keyword>
    <keyword evidence="7" id="KW-0187">Copper transport</keyword>
    <keyword evidence="14 16" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 16" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="318"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="753"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="781"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="834"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="872"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="910"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="942"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="17">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF0735880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="981" mass="106869" checksum="D645C4C7C6608A01" modified="2020-08-12" version="1">MAGGIEGVAAGLRTSLDRGLDSSKADDLKSREATFGRNYIQPPRPATILELMWEAFHDTTIIVLTLSGLVSLILGLTMEGESAEWIEGTSILFAVLLVITVSAVNDYQKERQFAALNAVKDDERIKVIRNGEPCEVSKYDILVGDVVRVDLGDILPADGLVFDESDLKIDESAMTGETDLLKKSRVEAPIMYSGTRVMEGVAKMLVVCVGVNSQSGIISALVQGKGAEEEKKAKKKPKKESAVGPVDDVPVAKKEQDEVYEEAAESPLQGKLNKLTVHIAKFGTSTAVIVFLAMTIRFSVETFGNGKTEWKKEYATEYLHFFITAVTVLVVAIPEGLPLAVTISLAFSVKKMLLDNNLVRHLDACETMGSATTICSDKTGTLTTNRMTVMQCWLGGKEYSAAAQLQGEISDSLKEAFSHGVCLNSTAEILPPKVPGQPYEHTGNKTECALLTFCKDLGIDYSSVRKTHPVAHMLTFSSKKKRMSVVAARGVNCRVYCKGATEVVLGLCSKMKRLDGSVADLTQAEKDDIGHSIIEKYASQGYRTLCLAIRDLDISTDEVKQWPDDDIETDLTCIAIVGIEDPVRPEVPEAIRQCHRAGIVVRMVTGDNIMTARSIASKCGILKPNDGALTMEGSEFRSRVLDKNGQIIQEEFDRIWPLLRVLARSSPKDKYTLVTGLKQSNVAAYGPQVVAVTGDGTNDAPALKKANVGFAMGICGTAVAKDACDIILMDDNFTSIVNAVKWGRNVYDSIAKFLQFQLTVNLVAITLAVLGAIVIEESPLSAIQLLWVNLIMDTFASLALATEKPNQAMLERKPYPRTQPLLSPKMVKHIVGQGIYQLIVLIVLLFKGEVIFGLPSGRKADQPPELKGSRSVHYTMIFNTFVFMQLFNELNCRKIHDEINIFTGLADNSIFASISAFQVGAQVLIVQFGGKPFSCVGLDATQWFYCMLISAMSLPLGLLLRLLPTPTWLGGRTAATDVVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X7G8</accession>
    <name>A0A6G0X7G8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_007847</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000093">
        <property type="protein sequence ID" value="KAF0735843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X7G8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006195"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF0">
        <property type="entry name" value="CELL CYCLE SERINE_THREONINE-PROTEIN KINASE CDC5_MSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="22"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="445"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0735843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="557" mass="63822" checksum="E0420A377E9B14CE" modified="2020-08-12" version="1">MPSYPPRDDSMIPFITRALRNGREKEYHAMGTFKISTEEEALADNVFVAFNTRRRREQLVVKLMDDDLEMDFMNYMNRRDIPELFNHVVEWKDWGDITFPNNIGQCIGLVLEAGTATLENRLRESVMKEDEYAKYSCVAHLINGVKMLHAQNIIHGNISLDNILYFGDKGHFKFIDFAVATLINQPMQSMCTPEYCPPEMAKHLLNPTPEGIPAKAEYDIWCLAVVILKMFMPNFTLVEFVHKSDRAVLEMIASDDFSFKKSFEACTLSTPQRDDLAKCLNLDPTLRASLQSLWSLLPRKTTMDANIRRVERQLMASQKTQVQLDKYKVPCLWTLEDTNPNPSGFIARGKRLLMRKFRIVFLCELRDEKPCEHYDDDAPILEANSDLMKQILPVLKASCLVVKALGLVVGWGGIIGDYFNFDMSKYTTLETVMDAVSSINDVADRLDLEEKLSSVVEKLEEERDEISEEEVQSLMDDIKDAFVKFRDDPATYQKLLNLLESAKFDWQKKVTIGGLEKKVVRIDDVKNNPDATGDASEAGEVRWVCKAHAETFKNRFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X8X6</accession>
    <name>A0A6G0X8X6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_007535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X8X6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020077"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="124"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0736525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="426" mass="46902" checksum="828E43F6D496EAB2" modified="2020-08-12" version="1">MGCGFSHFCGAQGLHDEDLDLAKSPPPRKRTFFRSNSFKSGVLIKSTTLEVKLHRQEVDEDDFEEITDVSIEEEEYIGDEPFVYVGGGIPGVAVDEFTIEQAKYTGHSRGGRRAFSQHLAWGSRTRAGNDSMGRRKENQDSFIVRDRFAGIDALTFVCVMDGHGAQGAFVSHYVRDRYPHHVADALLRHMTLMDSSTTLDPSAITLETIEDVFLDASCRMTIALEEESQLDISVSGTTAIALLFINPTDSLPHIVPRVFIANVGDSRAVAGVLSPENDTYIPHILSSDHKPNVPSEEARIVATNGRVFEYGVPRVWLQDIDMPGLAMSRSFGDSIATSVGVISDPCVTELDLTPGTFVVVASDGLWEFMPSEQVIDMCAKCISENQDPQTTCDMLVAEALERWLDEEDVVDDITVLYLTTCVPSPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XAC0</accession>
    <name>A0A6G0XAC0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Anoctamin transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_006848</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000085">
        <property type="protein sequence ID" value="KAF0737038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XAC0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001889"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF73">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="287"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="410"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="453"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="489"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="561"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="612"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="665"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="6">
        <location>
            <begin position="236"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0737038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="734" mass="84745" checksum="48EBE7F4B9EC710D" modified="2020-08-12" version="1">MTSMKKHNAHLRQKLANQHHDYGSMHLDINDPTVHWDYAIAFQNPETRKPGTPEPPTSMEEILRRLFSQGLQFRLYYSSTRDIILCEIRCHYQRLKIEADRIDMPVLLDADELRKTAERGFPKLGIKPFPINDVKKIYDFPPYEYIHAAFEDDDDKQNLFAKKNIDGTVFAPVKRMKLIESIIISKECCDLDLDKLILNGSILACYPLHNEDEIAILAKDWIPACKAPWDQPLDNIRDYFGERIAFYFAYLGHYSTYLLYAAVFGLLIFIAQSFLKETRTTLDSGEILVISSNLYLIPAFGLFMCIWSTIFLETWKREQNVLAMKWGMSGLSEEEIPRPQYTGEPIHSPINGTISIYFPKTQKYQRVAMSWGVLLLLISIVFLLVAGIFRLRYLWTKANPIVLPGIFSHIPFGSLLASLANVVQITIMGRIYYKTFYSFNEYENHETDSEYEASLILKTFVFNFVNNFAALFYAAFLKEGIEGCKDQDCLGELAYCLAIVFGVQLVIGNVREILLPRFYAWLSNRSVVKGVSVSDKVSEAEKQFFLSTYEFSGTFDDYTEMIVQFGYCSLFVVSFPLTPLLALINNYMEIRVDGFRLLYENRRSRPRSAGSIGLWLEIVEWCTTIAIFTNAYVVVYTSNTFDYLKTGTQFTNDAAIDEYAQATKLLYFIIFVFVMMLFRFFLAQVIPDVPVSVTAQLKRQQFFNNKAIFRMPDDTVSKYVGNNDEDFDMTIHEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XB01</accession>
    <name>A0A6G0XB01_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pseudouridine synthase RsuA/RluA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_006905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000085">
        <property type="protein sequence ID" value="KAF0737101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XB01"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021119"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF87">
        <property type="entry name" value="RNA PSEUDOURIDYLATE SYNTHASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="2">
        <location>
            <begin position="106"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0737101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="286" mass="32337" checksum="26FD81A6C1D528FE" modified="2020-08-12" version="1">MKLFAIGKGDVRMRLDRWLKANFQRPQSFFQRHLRQKQIFLYDVPTQRRVKTRADFILEENPALRIGMTQTLYDAIARDAVSSADPVDPVVPPELALPILYEDSSFVALHKPPRLATQLGTSTDDSVASRYPHWKLVHRLDKGTSGILLLAKTRLAAADMAALFRNNLVQKTYIAQVHGHLTALTGVIDAPLDDQSAKTSFRVLKVGENYTTWLELQPHTGRKHQLRMHCADFLKTPIVGDKRYGLPSSSSDRPSRLMLHASSLSFIHPTSHQRVVISCKDPTFHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XBN3</accession>
    <name>A0A6G0XBN3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_006721</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XBN3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007687"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827:SF1">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0737566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="167" mass="18326" checksum="C9C96CB4A6AACC0C" modified="2020-08-12" version="1">MPIPGTSKCAFHRHRNKCSFPNCNNQVVVNKLCVRHGGKRLCHADGCNHHARGGKWCLRHGGVTHKRFCTAPGCEKQAHANKKCIAHGGGRRCQVQGCTFFARSGGHCHHHLVYSATPGDSTTDFIDQLILDLVVDSTTCSFPFDDLKDLSIGSTTEDDLLLSQFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XC06</accession>
    <name>A0A6G0XC06_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_006372</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000083">
        <property type="protein sequence ID" value="KAF0737708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XC06"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018069"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="451"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="236"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="451"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0737708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="628" mass="69571" checksum="183955F8BBE171DA" modified="2020-08-12" version="1">MDNVGQAADTVSDHIVQSGRDLPALRRMVDHLEQLNNLARSYQDSYPEGGAREWADMVQEVEEARATIATLREQVAQDQEAMTHGREEAVKMLRRTGGADVTAYLAWPNTPVDEVVARQQVALVTALRDRDEAREYLRERGNDVLQLRGQLHQSNTAQHVLTEQVAKQNVEIKRLSALLSSERAIRESAELLQKLWLPMAVAKTPREVQSCERMRANEELKKKLQENRGALIQPGLQEVFAELKESESKRQVLVKEAASSTAEIVKLKRMLKAVLNDLDDRARETAEAVEEARDSAVKLKKWQSAFEEVTALRDEVILKIEELRDRLVLAVRNGVLGDEGLRGAVDFLNWSRDSFLVMGDLAGWVEAWHIRAPFPGTINVIGTGPAQASSPEVPLPAIADVSLVDAEVTKWRAFADDLVARLRAQIVSDPELLAGLVADACVGVEETAGAETQTSFISPRSQPQASTLGSDDPNLAFTDDDFQLTGATDALGSQGRKRPIVTSPTKSKRSCKGAHLAALMSPRSASTGPARNKEVTPAIVRAYEAMMATKPWERYQHLPSIFPAERANEATRMVDEALKAFWLKRGREVFERMFYLKLDSATDKYGSLDQIAGPLEMVLASLKIAEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XC31</accession>
    <name>A0A6G0XC31_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_006370</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000083">
        <property type="protein sequence ID" value="KAF0737706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XC31"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015709"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.10.10:FF:000007">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="10">
        <location>
            <begin position="555"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="857"/>
            <end position="885"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0737706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="885" mass="101846" checksum="C41D0F41EC6B4ECB" modified="2020-08-12" version="1">MIRKPDGSIRFCIDYRRLNEVTIKDSYPLPRIDDLLDVLGKAKYFSTMDVASGYWNVRMEEDSIPKTAFTCKFGLYEWLVMPFGLCNAVPQFERLMEHVLRDQIWRSCLVYLDDVIVYSDNFTSHLARVNDVLCCFARAGFKLKMSKCHWGKSSVAFLGHIVTPAGILPNPEKVKSVLKIHELRNVAEVRAFLGLAGYFRRFIKGFAAIANPLEQLKTSPSFQWTEECKRSLDTLKQKLVSPRWRIPISNNPSSFTWTPARSRQALDATQRRWINKKDGTSEIECFGLVWATTKFRPYIDKRHFTIYTDHGSLVWLFKVGSKSGNSKLARWIIQLQALDFTVIHRPGTAMGCADGLSRLPISAITRSAAARQQTVIPDLADSPTQALPSMAETTPDPELPPYNDDSYELPTSLLAGAQADDPFIIAMKAYIQDSALPADPSLLTLVTRTHDQYALQGILLCRRVILKTPIRNPEIHLVPVIPLGWTRRVLQLCHDSPLAGHFGVARTLDRVRRVAYWHGWRSDVHEYCRVFVRCGAAKGSRPWRQGRLQGMPIYLLRGPFNFLVVDALGPFPITPRENRYVLIFIDYFTRWPEAFAVPDLKTSTFTRVLIDEVLCRYGVPERLLSDRGTNFVSELAHSMYKVLGIDKLSSAAGHPQSQGLVERFNSTLATMLKVYVNSVQTDWDLYLPRLLWAYRTAYHETLGDTPYFCLFGLDPISPLHLTFLNQDPPWRSDDLPQWRRQQSSWFLATRRLVESQLIKGQNRDQRTSRQRPIEFQPADSFWVYQYFRKSRHDDDTRISKLAYHWHGPYRILSKQGSNTYRVYLPSLPDRDFPVNVDRLKLFQGYWSRPYDEDIPDRLRDLAGGEQPYARRKSTEPGYSGHLDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XCI2</accession>
    <name>A0A6G0XCI2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GTP-binding nuclear protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_006283</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the small GTPase superfamily. Ran family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000081">
        <property type="protein sequence ID" value="KAF0737790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XCI2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016531"/>
    <dbReference type="OrthoDB" id="48625at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00877">
        <property type="entry name" value="Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000131">
        <property type="entry name" value="GTP-binding nuclear protein Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002041">
        <property type="entry name" value="Ran_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071:SF0">
        <property type="entry name" value="GTP-BINDING NUCLEAR PROTEIN RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071">
        <property type="entry name" value="RAN GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00627">
        <property type="entry name" value="GTPRANTC4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51418">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0737790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="213" mass="24361" checksum="D3757CF6CCA4F7C0" modified="2020-08-12" version="1">MAQQMPEFKLILVGDGGVGKTTFVKRHLTGEFEKKYVATLGVEVHPLKFETNFGPIKFNCWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRISYKNVPNWHRDLFRVCENIPIVLCGNKVEVKDRKVKAKQITFHRKKNLQYFDISAKSNYQFEKPFLWLARKLVGDNNLTFVEAAAVVPPEVTMDEEHKRQMEAELAAASNLPIPDEDDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XD74</accession>
    <name>A0A6G0XD74_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_006053</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0738062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XD74"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0738062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="72" mass="7590" checksum="380657F1633667E8" modified="2020-08-12" version="1">METDVGSNSHECLLAATENKEAAMTHAITARACVDCLGSLGAFGRSCDEGVPSSTCFQSGNRVLLLSSREWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XDR9</accession>
    <name>A0A6G0XDR9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_005876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000077">
        <property type="protein sequence ID" value="KAF0738319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XDR9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001169"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0738319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="302" mass="32900" checksum="83D8CFF8F20332C4" modified="2020-08-12" version="1">MLSRVAARLIAAPAVRGVAARGLATNAPVAVQRPKHTGPPTLQSTVAEIKYLGTVYSIAASATQLSKEKLEFVVREIKSEKDLTLAREALELYERNYLHIPKHCTGTFVSKCIKNGQADLALDWMANSPSLSKYIVNGTSANLISHYAETGELEKGLKVAEIVKQHKMELSAKVYNALISLCKKQGKMDLAIQFATEACHAKMMNAHGFLLLLDGLSDSELEKTIPLVKSLIHLGDVYTNAKLRELLHEDSAATPVISNAASAEVEDVEQVEADDEEEGDADEEEIQDESADDKQTEDSKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XDS7</accession>
    <name>A0A6G0XDS7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_006182</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. The alpha chain contains the catalytic site.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0738207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XDS7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005402"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14132">
        <property type="entry name" value="STKc_CK2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000059">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000088">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045216">
        <property type="entry name" value="CK2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="34"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0738207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="339" mass="39810" checksum="257F59998BB2B6EE" modified="2020-08-12" version="1">MSRLRVYADVCETRPKEYWDYENLDITWGEQDAYEVCRRVDRGRYSEVFEGIEVATGNRCCIKILKPVKKKKIKREIKILQNLSGGPNIVQLLDVVRDPQSKTPSLVFEYVNNANFKTLYPTLTDFDIRYYIYELLKALDFCHSNGIMHRDVKPHNVMIDHEQRQLRLIDFGLAEFYHPNREYNVRVASRYYKGPELLVDMQEYDYSLDMWSVGCVLAGMIFRKDPFFQGHDNYDQLVKIAKVKGTDELFDYLTTYNLDLDPHYDGLLGSHLKKPWEKFITADNKHLVSPEALDFLDGLLKFDHQERWTASEAMGHAYFQVVRDYHDAQHVTTDAAMSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XE99</accession>
    <name>A0A6G0XE99_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ae201684_005748</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the proteasome inhibitor PI31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000075">
        <property type="protein sequence ID" value="KAF0738396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XE99"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010953"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045128">
        <property type="entry name" value="PI31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013886">
        <property type="entry name" value="PI31_Prot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021625">
        <property type="entry name" value="PI31_Prot_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13266">
        <property type="entry name" value="PROTEASOME INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13266:SF1">
        <property type="entry name" value="PROTEASOME INHIBITOR PI31 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08577">
        <property type="entry name" value="PI31_Prot_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11566">
        <property type="entry name" value="PI31_Prot_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PI31 proteasome regulator N-terminal" evidence="13">
        <location>
            <begin position="71"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="PI31 proteasome regulator C-terminal" evidence="12">
        <location>
            <begin position="223"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="193"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="266"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="285"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF11566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF0738396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="333" mass="36340" checksum="7A3A3C36F4D166AD" modified="2020-08-12" version="1">MDPDALTRAREERQQLQTQIDSLPDGLVKTHMLNALAELDEVIQRNDPATSSTTASDDPLVRRMKSNAVMVKKPQDALVATIHFMMQEAGFVTSGNTSGDTLYLPREWDKDSDQGIFIFTYTHPNQPGVQFTLKALFVGQILALHIVQGDSQVHSLDIKIATYIRDTSSTMAGDALQASGLLRQQWTGFSQAFRPKEKPQPDTSATPSPLSIPTRAPLRMEPTQPDPLRIPNVGGGDAFPNFGGDSRRFPGMEVGPGHPLFGGRFGQGGYPEGPVPGARFDPYGPVGPRPTNVFPPFPMRHPRPPPPPFGGPDPDHLPMPGHPRDPDLDDMFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XEJ7</accession>
    <name>A0A6G0XEJ7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_005541</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000071">
        <property type="protein sequence ID" value="KAF0738613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XEJ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008191"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000059">
        <property type="entry name" value="N-ethylmaleimide reductase, FMN-linked"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="4">
        <location>
            <begin position="4"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0738613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="356" mass="38458" checksum="21E2DB0A75944A64" modified="2020-08-12" version="1">MAANLFSPIKIGSVQLANRIIMAPLTRTRAGPSHVPNDLMKEYYAQRASAGLIITECSMIAPDTSAFVGEPGLYTDEQLKAWKGITDAVHDKGGKIFMQIWHAGRAAHPDNNGGVDSVSSSAIAIEGETHTLLGKKAYAVPRALTVDEIKTIVQQFATAAKNSIEVAGFDGIEIHGANGYLIDQFLRSSANTRTDNYGGSLENRSRFLTEVLEAVTAAVGADKVGIRFSPLNSYNSMKDEDPIALSEHVAKIAQRFNLAYVHILRSDLLKAQEGDIEPIFRKHFHNTFISNAGYTKDEANAAIESGLVDAVAFGVPFIANPDLVERFKLNAGLNTPDPSTFYVPGAKGYTDYPALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XET7</accession>
    <name>A0A6G0XET7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_005340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000070">
        <property type="protein sequence ID" value="KAF0738719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XET7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001983"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="277"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="143"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="282"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0738719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="305" mass="34874" checksum="0C5C7BD2EAC4C2B0" modified="2020-08-12" version="1">MDQVEEEYAQDDITIDLSFENAELDFELLDEATEESKDAPQTDSERVQISVQQVKETLQSVPNTDSNLQAHISTIADYLVQLEEKVRDLTVKNAMQTIDLHNLRQLYQASIEENEALATKKEAREAKEANKTLLDSNKSSNQIKAQLQEYMELDMEVQKAKQDNSKLTAEHERVVELCAKFQEEVLLKEIEVAKSDKRLHIMAAQLDNTKELHEQVVKENADLRAQMEAMATQNQTLLKHKKLLVLEVKALQKYSHVNIAGLEQEAQEARMMQKSISAQLERAQEERDELKEKLNELNISGVDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XF56</accession>
    <name>A0A6G0XF56_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_005473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000070">
        <property type="protein sequence ID" value="KAF0738864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XF56"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003276"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04697">
        <property type="entry name" value="NUDIX_Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885:SF0">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0738864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="141" mass="16062" checksum="E3096EBFD1FC2907" modified="2020-08-12" version="1">MKVYHLPHRATFIVVRNSASLYYVQRRSLTKDYCPGYLEPMAGGVVGVGEDCDDSARRELEEEMGIRDTSISHVATFSYSSPPMLTWRSLYECVYDGPVTMQEEEVSEVLLMSADEILQRQNEMTPDGIFAFLTYLKSKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XFF3</accession>
    <name>A0A6G0XFF3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tetrahydrofolate synthase</fullName>
            <ecNumber evidence="3">6.3.2.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Folylpoly-gamma-glutamate synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Tetrahydrofolylpolyglutamate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_005484</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + L-glutamate + ATP = (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10580"/>
            <dbReference type="Rhea" id="RHEA-COMP:14738"/>
            <dbReference type="Rhea" id="RHEA-COMP:14740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:141005"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.17" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000070">
        <property type="protein sequence ID" value="KAF0738875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XFF3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004315"/>
    <dbReference type="OrthoDB" id="5212574at2759"/>
    <dbReference type="UniPathway" id="UPA00850"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.10:FF:000008">
        <property type="entry name" value="Folylpolyglutamate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="entry name" value="Mur ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF5">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0738875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="510" mass="56602" checksum="1F44966FC4F2D7A4" modified="2020-08-12" version="1">MTVAHKGLSDYTQEEVERFRARGIDGAMDILLGMPGRPAYVGKTSDSREVAIEMMVSYLKRLRMDISGLSIIHVAGTKGKGSTCAFTESILRAHGAKTGMFTSPHLIHPNERFRINGKPISDEIFLTNFWAVWDGLSATMNEAQGFPPIANFFRFFTLMALRMFQEERVDVVILEVGLGGRLDATNVVEKPVVCGITTLDLDHTRVLGDTLDKIAREKAGIMKSNVPVFTIAQPEIAANMLAKCSIEHNAPLVVVPPLSDFNISAHDLKHSLGMHGEYQRVNAALAIVLASTWLGAKHGTPLPPFNAIITPTILEGLKLAFWPGRSQTVVDPLSSTIFHVDGAHTPLSIECCAQWFESCCEATPTQRRIFIFNCHHERDVVTLFLPLLKLHFHHVVFCPSRSCRPSIVKIPSVEEALLKANLDIAGLPSDVFNTDAFPPQDDRMYWQFVCEKTWTILNQLHGFPTATSIFPSVEKTLEWIRETAPQDTKVLVTGSLYNVGDTLSALEWKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XFY0</accession>
    <name>A0A6G0XFY0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-reducing end alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="4">3.2.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_005202</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 62 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="4"/>
    <dbReference type="EMBL" id="VJMJ01000067">
        <property type="protein sequence ID" value="KAF0739014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XFY0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013389"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005193">
        <property type="entry name" value="GH62_arabinosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40631">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE AXHA-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40631:SF1">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE AXHA-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03664">
        <property type="entry name" value="Glyco_hydro_62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0858">Xylan degradation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0739014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="145" mass="15986" checksum="97169CF2D61F224F" modified="2020-08-12" version="1">MPIGNFPGNFGSSYTTVLSDSRANIDEAVQVYKLKGQNKYLMIIEAMGSRGDYFRSFTAPTLDGPWTVQAGTESNPFAGKANSGATWTNWISHGDLVRTNPDETFTIDPCNLQFLYQGFNPSSKAPYDALHFLPAVLTLQNPVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XG85</accession>
    <name>A0A6G0XG85_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_005247</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the p23/wos2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000067">
        <property type="protein sequence ID" value="KAF0739066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XG85"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013353"/>
    <dbReference type="OrthoDB" id="1564555at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06465">
        <property type="entry name" value="p23_hB-ind1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000039">
        <property type="entry name" value="CS domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045250">
        <property type="entry name" value="p23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932:SF1">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DAF-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN P23 HSP90 CO-CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="3">
        <location>
            <begin position="5"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="129"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="148"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0739066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="163" mass="18684" checksum="51B7660DECBF89A5" modified="2020-08-12" version="1">MTQRALWAPVKWAQRKDSLYVTVDLPDVKDEKVILTNSSLKFLGSSNQTKYEVNLEFLHEVDTDAAESKWAKTDRNVHFYILKKDKEAAFWPHLLKDKHLEKTNVKVDWNKFVDEDDDDDTGFDMSALSGGGGFDINQMMAQQGANLPDEEDSDDEDLPDLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XH06</accession>
    <name>A0A6G0XH06_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_004929</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000064">
        <property type="protein sequence ID" value="KAF0739360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XH06"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019360"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000610">
        <property type="entry name" value="Multidrug resistance-associated ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000997">
        <property type="entry name" value="Multidrug resistance-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="525"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="297"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="618"/>
            <end position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0739360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="862" mass="95629" checksum="E535CACE7423E2E1" modified="2020-08-12" version="1">MTIKNGEFVVVHGSVGEGKSSLCAALLGEMAKFSGNIFVGGRVAYFSQQSWIQNLTVRENILFGKPYDREKYNRVIEACALVKDLSLFAAGDRTEIGQKGINLSGGQKARVCLARACYSDADIFILDSPLSAVDAIVQNEIFTKCFLGLLRNKTILLVTHAPDIIGSEYIDRLIEIKNGQLIESVVASRKTTLEPLVKPLPARPARYVVEADDDVVVEEPPRYDATYNSGSLISPSISTPLHGSGNPLFTPVNKVSTDEFVEASGQLVLEEERSEGSVSGDVYKTYFEAGGGWCMALVLLLSLLLWQGLMISSDLWLNVWTNSVNKVSSKEFINQSTYYLSIYALLSLFAVAATILRSLTMYSGSLRASSSLFDQMSSALLRAPMRFFNQNPVGRILNRYTNDTSTMDVDIPFWGGFIISSTFLTVCTMATAIYMTQALGLFILPLVYLYIAMGYFYVKPLRELERVNKITMSTLLNLISEAIEGVLVIPSFGDKQLRRFQRLHFRNVDISNESMFAKEITTQWFALRIQLTSAAVLLIVSTSLVVMRGQLTAGLMGLCLNYVFSSLDLLEYLIPAYAKFETFMVSPERVIEYCKIEPEAPRLISGAVTKEWPTKGDIVFQNVGFRYKENDPLVLKDVNVHIQAGEKIGVDGRTGAGKSSLTMALFRINELATGCIKIDGMDIAKVVVKTLRSGNAIIPQMPVLFKGTLRNYLDPLGEFSDDQLMSCLRKVELVERISGNLECPVEENGENFSVGERQMLCMARALLRQAKIVVMDEATASIDHTTDQNLQRVIRKEFASSTVLTIAHRLDTVLDCDRILVFDHGRLEQCDSPKSLISQGNGIFFELCREGGYLDKLTASEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XH56</accession>
    <name>A0A6G0XH56_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mannosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_004978</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the eighth mannose residue in an alpha-1,6 linkage onto Man(7)GlcNAc(2)-PP-dolichol to produce Man(8)GlcNAc(2)-PP-dolichol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29535"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="Rhea" id="RHEA-COMP:19518"/>
            <dbReference type="Rhea" id="RHEA-COMP:19519"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:132517"/>
            <dbReference type="ChEBI" id="CHEBI:132519"/>
            <dbReference type="EC" id="2.4.1.260"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:29536"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="VJMJ01000064">
        <property type="protein sequence ID" value="KAF0739410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XH56"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016857"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052917">
        <property type="term" value="F:dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF1">
        <property type="entry name" value="DOL-P-MAN:MAN(7)GLCNAC(2)-PP-DOL ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="155"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0739410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="611" mass="68895" checksum="421E89227DB39678" modified="2020-08-12" version="1">MEDIVLFCVGIFQVWITPYAKVEESFNLQACHDLLFHQFNLTQYDHFAFPGVVPRTFLGALPVSLISSPLLVLVSKPAMQMTVRACLWLFAFLAWRSLKRTISSRFGNDTGVWFTVITLVQFHLVYYMSRTLPNIFALVLVLFAFSFWMENKPKLVIVLLSFSTVVFRGDTAVIFAPILLSLLINQQISFLAMIGTGIASAFLALASTVLVDSYFWQRWLWPEGEVLWFNTVLNKSHEWGTHPFHWYFTSAFPRIMLATAVLIPLGATSLGTVVSSSKSPSVMFQNLRGTSCLDLSTCQYLIPIVVYVFLFSFLPHKELRFVLNAVPIFNFAAAMGITKLWRNRSKNIWPLMLAFGCIFVTAAGSVVFTIASHLNYPGGVAFAKLHELAQAHQNESIMIHIDVASAMTGVSRFGEQYPAWTYLKTEDLTSASDFNKFDYILTAAPTDSSKQDFKVIEAIEGFDRVDYRNERTANKCFQSKMFHAIFFNGAQSDENKRRYRSVSFPTWRSRVTRLAAVMMCSSNGLAINRDAMPSMLKYTLLNLPSHQQQCLNHQSPEPATRASTPRTRVKIKTPARAATTAARLVAPRAAPVATEVVKRRALCLPTMRHPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XHQ5</accession>
    <name>A0A6G0XHQ5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_004597</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the citrate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000059">
        <property type="protein sequence ID" value="KAF0739851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XHQ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011389"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046912">
        <property type="term" value="F:acyltransferase activity, acyl groups converted into alkyl on transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006101">
        <property type="term" value="P:citrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.230.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.580.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010109">
        <property type="entry name" value="Citrate_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01793">
        <property type="entry name" value="cit_synth_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007128">
        <property type="entry name" value="PRK09569.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739:SF8">
        <property type="entry name" value="CITRATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="3">
        <location>
            <position position="339"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR610109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0739851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="505" mass="57089" checksum="73FA3D28E91FDDE4" modified="2020-08-12" version="1">MKKRAEKTIFSLFLFDKVVSSTFGLSFFSLHFRIFRFVTQALDNMFASTLRRVSTKVASNKAAFSSSSSTLYDVLKAQIPVRQEALKKLKAEHGNKSLGNVTVEQCIGGARDVKCMLWETSLLDSEEGIRFRGHTIPDLQKKLPTYIEGGEPMPEGLIWLLLTGEIPTREQVDGLTKELHSRSKIPAHVKQMLCDLPKGTHPMTQFSIAVMAMNTDSVFQRKYAEGIHKSTYWEHTYEDMLNLIARIPEIAATIYRSTYFDECLDINYDSSLDYSANFARMLGYDSQDFDELMRLYLVIHSDHEGGNASAHTTHLVGSTLADPYLSVAAGLNALAGPLHGLANQEVLGWIMDLHDEFKSKGLPVNKETITKFAWDTLKAGKVIPGYGHAVLRRTDPRYSCQREFALKHMPNDELFQIVETIYQVMPGILTEHGKTKNPYPNVDSHSGVLLYHYGLTQKNYYTVLFGVSRAMGVLSQLFWDRALGLPLERPKSVTSEWINEHFKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XIX8</accession>
    <name>A0A6G0XIX8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Association with the SNF1 complex (ASC) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_004256</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000053">
        <property type="protein sequence ID" value="KAF0740253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XIX8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016754"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.250.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006828">
        <property type="entry name" value="ASC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037256">
        <property type="entry name" value="ASC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050827">
        <property type="entry name" value="CRP1_MDG1_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343:SF84">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04739">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01010">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160219">
        <property type="entry name" value="AMPKBI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Association with the SNF1 complex (ASC)" evidence="3">
        <location>
            <begin position="182"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0740253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="273" mass="30205" checksum="1AF27ECE0F1CA058" modified="2020-08-12" version="1">MGSTSSKPHDSNPTDLGTLESHKDSATSISGLSQPPALYYGSPNHHAQASRNSDTDMDMEGVNSPRYVPSKTSATTSTPDSSSKNDIVPMVFRWEHGGRNVCITGTFNGWSAHVPMHRSGNDFTYIANLPRGKHAYKFVVDDEWRFAPDQPTVADVDGNINNYVDVSDFASLADVDLDQPDDNDQETVYGRFIPDIDEYTKEPPPLPPHLRHIMLNKAPPSVDCRLLPVPQHVALNHLYSTAIKDGMIVLGITQRYKQKFVTTVYYSLMPGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJ22</accession>
    <name>A0A6G0XJ22_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_004288</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000053">
        <property type="protein sequence ID" value="KAF0740288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJ22"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004150"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052050">
        <property type="entry name" value="SecEffector_AnkRepeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586:SF3">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0740288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="320" mass="35653" checksum="129DD6683806859E" modified="2020-08-12" version="1">MNRVLRCRDFLVAITRFQRGVYEDLRPLAAWIDRTTCLALPTFLHDNGQTSIYRIVQAFHAVFDPWLAASTVDSAAALHRLFQCVHHLHLPALFHSIVYRRLDVLHVINERSRIASIDNVLDFAVRSGFDDVVRLLHSWGAQGCSTYAMDTAAHNCNLRLVEFLHANRSEGCTADAMDSAAWQGHLDVVRFLHSHRHEGCSERMMDWAAGNGHLNIVQFLDANRTNGCTTFAMDMAAERGHLHVVQWLHTNRTEGCTARAMAGALRNGHLAIIEYLKVHQVAAATTSAALAGLDCIRLPRHVGIAAEDKSHLQSAAVEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJB5</accession>
    <name>A0A6G0XJB5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">choline-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="8">2.7.7.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_004125</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.15" evidence="8"/>
    <dbReference type="EMBL" id="VJMJ01000052">
        <property type="protein sequence ID" value="KAF0740388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJB5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005170"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004105">
        <property type="term" value="F:choline-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02174">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000167">
        <property type="entry name" value="Choline-phosphate cytidylyltransferase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041723">
        <property type="entry name" value="CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045049">
        <property type="entry name" value="Pcy1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739:SF13">
        <property type="entry name" value="CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739">
        <property type="entry name" value="CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="10">
        <location>
            <begin position="62"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0740388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="292" mass="33368" checksum="4D63859D13D7B527" modified="2020-08-12" version="1">MAKKLTAAAKAEKRKRAHDEEHVEEDARVEESDKKIEPIIIQGRELKEGDPGTLTGRPLRLFADGIFDLFHFGHARALQQCKQAYPNVYLLVGVCNDEVTHRLKGQTVMTEAERFESVRHCKWVDEVIEGSPWVLTDEFLEEHNIDYVCHDAIPYTDTSGTAGDSDDVYGHIKAIGKFHETQRTEGISTSDLIIRIISEYDTFIRRNLKRGYSGKEMKVPFLKEKAIQIDMAMDKVKHDIDTAMHNLLGKAEDVQHSFLNLFSKEGALRTSLRKRRKILQESLKDMAREGLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XK27</accession>
    <name>A0A6G0XK27_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_004013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000048">
        <property type="protein sequence ID" value="KAF0740639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XK27"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009214"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0740639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="371" mass="41010" checksum="72CDD25E9432710F" modified="2020-08-12" version="1">MDLDMNRLEMDSVDRQFGIESSHLMQAYYTNVGVDLQVHVKESPPRPSRHALPCPPSTEIPTQQIPNDTWPQTQRGQRQVAPRAVSRPVSASATSFSSSLLPLIDTRVETQSGGLKPDQLRVLTRPQTPKAATLCRRQCVDTNQTDFWSSSHRISTRARRKDPIVPQRPPRMQTPSSDNKTTDGNIKSTAPRPPAIRIPHLATFASTTATPSAALPTTAISIERPEVDIEKSAATSRRSAPDAVHGDLDKVVCAKQFSSMPRTEPPMDLATDLSSFMAKMQECSNKMTRRVKCMDAYMRKQPPRAAKVDETLLATKTTAACPSRQSASAACGLLASSKLSNSSRSSLRQKRRTIEDFGLWRSWTIPHNTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XK35</accession>
    <name>A0A6G0XK35_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_003964</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000048">
        <property type="protein sequence ID" value="KAF0740587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XK35"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010245"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0740587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="105" mass="11246" checksum="E2866894A56258CF" modified="2020-08-12" version="1">MAHIKPTCTHTASCFGRLQRQAIPSVDELALLSTSSIDLNSSKFSSGSLSEKFRALASSCIAQDPTRRPSASTVKSIVHSMVEEMLVLELASDMQSTTVETEADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XK98</accession>
    <name>A0A6G0XK98_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">Alkaline phosphatase</fullName>
            <ecNumber evidence="2 11">3.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ae201684_003913</name>
        <name evidence="14" type="ORF">Ae201684_003915</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the alkaline phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.1" evidence="2 11"/>
    <dbReference type="EMBL" id="VJMJ01000047">
        <property type="protein sequence ID" value="KAF0740681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VJMJ01000046">
        <property type="protein sequence ID" value="KAF0740714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XK98"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007659"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16012">
        <property type="entry name" value="ALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001952">
        <property type="entry name" value="Alkaline_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018299">
        <property type="entry name" value="Alkaline_phosphatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596:SF5">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00245">
        <property type="entry name" value="Alk_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00113">
        <property type="entry name" value="ALKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00098">
        <property type="entry name" value="alkPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00123">
        <property type="entry name" value="ALKALINE_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="6 9 11" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033536834" description="Alkaline phosphatase" evidence="13">
        <location>
            <begin position="19"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="482"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="497"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="508"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="8">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="432"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF0740681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF0740714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="518" mass="57072" checksum="D58EE8C230881387" modified="2020-08-12" version="1">MLAKISTLLAASIAISLAFSFDDSRPNIDYDYDIDEDHLMPRSVIMMIPDGTGPNIWTLARNMIDPTHKKMLHIDPLLKGTVQTYSNTSLITDSASSATAYSTGFKTYDAAIGVDMEKKPLGTILEAAKARGMVVGMIVTSRVTHATPASFAAHIDDRDLENDIADQYCANTNLDFLLGGGKRHFSDACLAKLKAAGYTLSYDKDDLAAYRKANEQSGALRIFGLYHKSHMSYEVDRIRGETKEPSLSEMTEHIFAILKNNKRAQKHGFFLMIEGSRVDHAGHSNDAGSMGKEAIEFDNTVGVVKKFVYSNPNVAMISAADHGTGGITLGRVDLYKWFPEPMVKQLMSTEWMESLFSKERATYDEASALKKITDLITKNTATTEVPENWITIFKGEVKKLVADPKYKTDNLLVYMGQCISETARIAWTTTGHVGTDVNLYCAGPSVFTRRCDGNHDNTHVNEIMTNYLNLDLQPITLKLRGFKPNDDKTAPPPVTPTPTNATNTPTASITFPPTTKAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XLQ5</accession>
    <name>A0A6G0XLQ5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ae201684_003709</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000041">
        <property type="protein sequence ID" value="KAF0741146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XLQ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009629"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17997">
        <property type="entry name" value="DEXHc_SMARCA1_SMARCA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000082">
        <property type="entry name" value="ISWI chromatin remodeling complex ATPase ISW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000005">
        <property type="entry name" value="Photoperiod-independent early flowering 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1190">
        <property type="entry name" value="iswi atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.30">
        <property type="entry name" value="ISWI, HAND domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044754">
        <property type="entry name" value="Isw1/2_DEXHc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015194">
        <property type="entry name" value="ISWI_HAND-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036306">
        <property type="entry name" value="ISWI_HAND-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015195">
        <property type="entry name" value="SLIDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF49">
        <property type="entry name" value="SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09110">
        <property type="entry name" value="HAND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09111">
        <property type="entry name" value="SLIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101224">
        <property type="entry name" value="HAND domain of the nucleosome remodeling ATPase ISWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="212"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="506"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="769"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1042"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="74"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="816"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1058"/>
            <end position="1075"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009687"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022801"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
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            <dbReference type="ARBA" id="ARBA00022840"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF0741146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1097" mass="126138" checksum="EDF30FA90D8B48CC" modified="2020-08-12" version="1">MATVKASSNHDKNVAEGDKDHESDIESYSDDDSVNDGSAADDDNDNTSVSNGTDSTDIKAEDEEILSAEDKAAREALIREEEEALRRQKESQAKALEVLREQEQEVEAEAANSRGKSNADRRLQFLMAQSDVFTSFLMGGSSAVGRAMNKKRGEAKQESDNRRSVKKGGDDDDQAAILAEEESRFTRLEKQPSNIAFGTMKPYQLEGLNWMIRLHDSGVNGILADEMGLGKTLQSISLLAYLRESRAMKGPHMIIVPKSTVGNWMRELGRWCPSIRTFKFMGDKEQRNVLRESIKTVKWDVCVLSYEVAIIEKATLKRFKWKYMLIDEAHRIKNENSKLSQVVREFDVQHRLLITGTPLQNNLHELWALLNFLLPDVFTASEDFDSWFNVDGEAGHENVIKKLHTVLRPFLLRRLKTDVEHSLPPKIETKLYVGLSEMQREWYTRVLHRDATHLNSIGGSDRVRLLNILMQLRKVCNHPYLFDGAEPGPPFVEGPHLWENCGKLVLLHKLLPKLKAQGSRVLIFCQMTSMLNILEDYMRYHNHDYCRLDGSTQGELRDEYMDVFNAPNSTKFAFLLSTRAGGLGINLATADIVILYDSDWNPQVDLQAMDRAHRIGQTKTVRVFRFITDGTVEEKIVERAERKLYLDAAIIQQGRLAQQNRKLSKDELMTMVRFGADEIFNARGSMITDDDIDAILAKGEERTESMKAKINEDMQHNLKNFSLSSVSSLYEFEGEKFAKDALESGVLPSTFIALPARQRKTNYDVDEYYRQQTGQTKPKKTKKPEDDNKPKVAVVHDFQFYDKEKMLALLQKRYDLEFQRKEHMKLIKEAKSVKEEDDGGKVKQLEAELEKMELSEEDREALEELEKNAFGDWTRRDLKQFVASCERFGRHDKEAICRDTATVLGKDLNRVMEYYDVFWERGPELEDFTKFIEKIEKGEKRIQRNQAVKEALAAKCARYKNPWRDMKLQYPGGYKSKGYTMDEDIFLVCMMHQHGFEWNAIKDEIRKAWQFRFDWFFKSRTVAELQKRGEFLTKLIEKENEETTSKMAAEDETLTSKATKKHKSSSSSSSKKRSRPSSSTTSSSSKRRKSKALNSQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XMB1</accession>
    <name>A0A6G0XMB1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_003469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000037">
        <property type="protein sequence ID" value="KAF0741359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XMB1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016712"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="345"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0741359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="497" mass="50670" checksum="AF646E8CF37CEAAE" modified="2020-08-12" version="1">MSELAAILARRRAKDGTGEEPPKETPAPAVSLPSTRPSPPKVFAPKPFANAPAPLDTASSTATATSTATSENAEATAAPVEEQPTPRKTSSKIAALQGNLGALNVNAFRPPPTRKAHTVSAMTTGEDYDYESTMKTGSSMPGMVGIPMIGLAKPGFALPGMAKKESTPDDESQASSEPEPAAVSHATMARATGPKRRAPTKPKVATTAEVDKPTEPVGSEVSTDSTEPIVPSVPTESSIPSAPSVVSSAAPSVVPTAAPSEEPRRPSMGLFGALPSQPPAASAGTIASNTEKRPSGVEHTAEKRDSATLFGAASSDRPRPPSGGVSLFGMAPPPVVEKRTSGTQSLFGSDSGVNSSSSTVTSSSTEAASLSTKSLFEPETPPKPQPPLVSGPAKLQQLYAQDDDDESSDEWDDDKPNALFKSSPAPTATKQQVGGSLFGATPTPALNPAPVLKATQPPPPAKTAQPIGKATSLFGGDDSDSDSDDAEGLFGTGLPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XQ48</accession>
    <name>A0A6G0XQ48_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha-taxilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_002571</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the taxilin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000027">
        <property type="protein sequence ID" value="KAF0742475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XQ48"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009375"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026183">
        <property type="entry name" value="Taxilin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16127:SF13">
        <property type="entry name" value="GH01188P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16127">
        <property type="entry name" value="TAXILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09728">
        <property type="entry name" value="Taxilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="157"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="320"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0742475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="403" mass="45559" checksum="2FBD44C5466D61A3" modified="2020-08-12" version="1">MDKSPVLATSDRANEDGGRKRSLKHKHKHKSKSMSEDAEGNDADSPVKAQSKPKQSKDEPSSHVKDLLASKIAQLQVGDDSLDVDMSGIFSDGKLVEASRISWAESKESGDVEVMDQAVQAILGHMSLLQKKLSEMHSKYIVMREQKAAVLESNTKINATKGKLESLCRELQKQNKTIIAESRRIAEEEDAKRRQLSQQFQTTIEDVSKKMEQQGKDYVASLQDNEALQGKLKTFLSQYEMREEHFAHQLQAKDLAIQLAEAKLQHQVELTARESEKGQLSLEKAKQIAEREVALQAQLGSYSEKFEVVQETLSKSNTMFVTLRDEMEKMSKHIKKLEKDNAALKKKCDQYDNGAIEMLQERGRAAEESKRQQDKINKLEGLCRMLQAERNRLKEKTNDTAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XQI3</accession>
    <name>A0A6G0XQI3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CBM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_002408</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000025">
        <property type="protein sequence ID" value="KAF0742708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007330"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026038459" description="CBM1 domain-containing protein" evidence="2">
        <location>
            <begin position="16"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="614"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="444"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="614"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="674"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="701"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0742708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="783" mass="80741" checksum="5575C015224673EB" modified="2020-08-12" version="1">MKLALVTALIAAAAASDIEHFTQAPCETTKAPCTTTPAPRVTTTRPTTQAPCTTTSSPVTTTKAPSTTTHAPGTTTKAPCTTHPGAPGTTTVVPGTTRPGAPSTTTKAPCTTTASPGTTTAVPGTTRPGAPSTTTTAPSTTTVVPGTTRPGTPGTTPAAPRTTPVTPGTTRPGTPGTTPAAPGTTPVTPGTTRPGVPSTTTAAPCTTTVPLLELPQPHLEPPLPLLEPPLPLLELPLLLPARLLRLLELPQPLLEPPLLLLELPLLLLEPRQNHPCDPWYNHTSSWNDHEGTLHDDGCAWHDPPWHPWHDSFRSWNDPCRSWNYPNRTWNHPCRSWHDSCGSWHDSFRSWNYPSRSWHDSCGSWXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGATPSTGTTTAAPGTTPSTGTTTAAPGTTPSKGTTTAAPGTTSPGYPTLSPSTSAPGAPTPVPTCGYPSNNGNVPTNAPATKCTEVSVVGDATYCVSGSVCSGAGSLPSGVACPKKGDVAVKDCHKSLLSYADYYKMCVAPVDAACVKLGSGAWGCQWAPVDCSSTPGPTPASSTPGATTTASPWTTTPTPGYPTVTPANTVPGATTPTPGYPTVTPANTVPGATTTKSPWTTTPTPGYPTVTPANTVPDATTTKSPWTTTPTPGYPTLSPSTPSTTTKSPSTTTGAPSTTTKSPVTTTAAPTTEAPCTTTKAPTTTVPPSTFPPDDGYPTLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XQY0</accession>
    <name>A0A6G0XQY0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endoribonuclease L-PSP/chorismate mutase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_002228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000023">
        <property type="protein sequence ID" value="KAF0742829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XQY0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010057"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02199">
        <property type="entry name" value="YjgF_YER057c_UK114_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013813">
        <property type="entry name" value="Endoribo_LPSP/chorism_mut-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43760:SF1">
        <property type="entry name" value="ENDORIBONUCLEASE L-PSP_CHORISMATE MUTASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43760">
        <property type="entry name" value="ENDORIBONUCLEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14588">
        <property type="entry name" value="YjgF_endoribonc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endoribonuclease L-PSP/chorismate mutase-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0742829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="156" mass="16201" checksum="DB2E8783DF4540E2" modified="2020-08-12" version="1">MTDVNARIVELGYTLPPVSAPKGNYKLLTRVGNVLYTAGHIPTPANGDIITGKVGQEVTAEQAYDAAHIVALAILATLKNELGDLNKIKQIVKLTGFVNCVDGFTAQPSVINGASDTFAKVFGDSGVGARSAVGTNALPLNVPVEIEAIVELKSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XRM5</accession>
    <name>A0A6G0XRM5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_002175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000022">
        <property type="protein sequence ID" value="KAF0743118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XRM5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009958"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0743118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="467" mass="51303" checksum="9D816BD1865564E0" modified="2020-08-12" version="1">MKEDATRSASLTAMASPPSPTRVVSPTKVDPKLLSRLPTLDMLSINQNKSLSVRDRIREMHALKLAPFPADCHRASVVVCAKPRSITCCQNNAPTMLYLDLHGLSWKRRHIATNDLVGASIAKTDPTVFVVHYALHEPTLAFQMHQFEAESPTDATAWIDAIQTLVKWHARVPLDASRRIQVVLDAAIPSTSTTWTAVQDFFRLAAIDCTVVASYDLVAFGASIGSSSSFEATIVVGSSLSFHRVVNGLFTMSESTWRAVLPSMPLGLLQSPDALNVVFKAIKRKVRPRDLLACHFNHEFVVLATTTVEFGSMSWRTAAPALPSLQFQAVAATRPSKNQDEMDGANVNHQHFVELCSVYYPREDTKSYKGRIDIDPTVKAAPSSTSPPVLGLRLSVKQDQAVTGQWFTHGSVWHRWTEHRSLPRSSWTGIGMALPQPWAVAIDGSPPRLVSGHIQVDCVANILHCFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XSD9</accession>
    <name>A0A6G0XSD9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_001793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000015">
        <property type="protein sequence ID" value="KAF0743499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XSD9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004001"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005796"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="161"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="317"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="625"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="682"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="796"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0743499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="900" mass="105183" checksum="1D41E61FF031899C" modified="2020-08-12" version="1">MEKEWMADIWPDFVVVPPTILKPFMKELSEEEKQKRSEAVRMKMRLDEEALRVHERIAHAKQWTFVDNYYYNATTGESSWEMPPVMAYVPPQGWDIVKNQWKDGVVLTLPEDFQSLPPRNADMDENVVSARSDSGGSDSAVDEQLDPIDLRAQVAAEQSILEKFNKEAAASKLRLETLSHQLQKAVERKITDEESQIQAAYNALVEEEKKRRMKEARERQAAAMEAKAKLEKQEGKSKTPKNKLQNADMKLDVDLENIQIPVDDSQPRLCTPLTNVPSVRMHLKTDEAYQHMQTVRIKVDAHVKREDLLWEAHDNFRESIEKEIQAAQTALESTIQDMDRSKETLEKSKAEFERIKEAPPMPQLHSVPEVEGRTQFEVYDELMREWEENEVQRRVDIEELTETIAQMEHRLATTTLDRMRDDIACLQEILKCEIERGAGLWSKKREYGVWRTKMMLDRVDRDEQLVQLRLKLQDYTAEWEHCDRIPLQAINTLEKQRLQTQADQRREHFASKIDTTLKLIKSAEAAQRKLIQMELDALEFHRLRVEEEQYLHQETKGVWLEQKVSEDRTQQKILRSWLVLNYAREKRWRLLVSFDQIDESPWLAQEEWLVSQLRSRHEAEMVAIEEKYEVHIYELEQEIAKLEVQVQIAKQGKVQSDADKAMVMTIVNEADTLVEATKAETILCLKKQMDELILKMEALEKQHEERIDRLLAEHAVIREDLEKRLEVTAADAILRMQWLKAVKCELSDHKVLNKHLLCGIAALEKRRATEINDMQARISSQLSRIHRLEMWNMSLKQSIEANNDVLLQHQRKLEEKVREHRAEQRILRHEVWRQRISAQLLLTNAHHLVLFFLQGITGLCGHANDALRDAAVIPILVELCKMPSLSAEIRAIYKTLSSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XSN7</accession>
    <name>A0A6G0XSN7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial import inner membrane translocase subunit TIM22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_001887</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the TIM22 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion inner membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000017">
        <property type="protein sequence ID" value="KAF0743414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XSN7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011698"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042721">
        <property type="term" value="C:TIM22 mitochondrial import inner membrane insertion complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039175">
        <property type="entry name" value="TIM22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0743414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="155" mass="16884" checksum="889D3326C27D0EC7" modified="2020-08-12" version="1">MNELNRFIVESRESCVKQAIVSSVMGATMGVGLGVFLGTFEGAHGELVGNNMREQLYYGFRKSFIAGYERSVYFSKQFMVVGAIYSGIECTVERERASHDVYNTLIAGATSGAILGGWAARKLPAKHLLSNTAKGAASFAAFAAVMEFCLDRFRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XT88</accession>
    <name>A0A6G0XT88_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_001493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XT88"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002731"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026050756" evidence="1">
        <location>
            <begin position="20"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0743847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="223" mass="26015" checksum="C637F5DA431DDF43" modified="2020-08-12" version="1">MRAKIVLAFILLCASGVASSKSGTVPPQLPLHFEADLEIKSHLLDAKVKYPPSLRKMKIRYDFTQGLARADILAGYDNGKSYIRRYDTKKEYKVKYGQYKSCERAYLGEDMPVPEFPKDFLYQRNERILGQDCELWTHNIPQSDLRIHVYESKAFNVPIRLTQESRDEEGNWVKQITYDFLNMKVQPQDLSSFDIPGGYSHETCTRNVMGFPYIHAFDYYLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XUB5</accession>
    <name>A0A6G0XUB5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_001669</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0744036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XUB5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017730"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF117">
        <property type="entry name" value="SERINE PROTEASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026027389" evidence="6">
        <location>
            <begin position="20"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0744036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="472" mass="52218" checksum="95F4F17C4577D6D2" modified="2020-08-12" version="1">MQLWSLLLVPLVAAAASVGDKVFKLKHFRLEDYRHLYNNQSEQSGIEAAATQQWFASQLVDHTDANNKAVWKQQYFVNDQFYGGPGSPVFLFISGEDAINSVFIQGANYFIGELAQENKAMLVALEHRYYGSSQPVPDWSNANLKYLTSEQALADIATFQDYFIKQYQLSTSSPWVAFGGSYSGSLAAWLKLKYPTRFVGSVASSGPIQAQSDFSAYSDVVSNDIKIIGGSTCAQTLQDGLKEFHRLVASTNSNDAAMLKQLFNPCYTMNSDDDRAVLEFSLFLEIIGEAQYNPDNFKSFCTTYLSTSTPTIVPFLQIDRKLVLLQLVLWLCERLYRNYNHHGWMGSSGSATASGVFSPLKYATNSVLLNKLCQSAYGIANVDANVAATNQRYGGLKINVENVVFPSSSYDPWSALALSNSTGVANSKSQVVYIDGGSHCRDMYASRSTDTASVQWAHTQIRAAVKRFLTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XUB8</accession>
    <name>A0A6G0XUB8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_001655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0744022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XUB8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014340"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0744022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="423" mass="46779" checksum="27A1735218198B6B" modified="2020-08-12" version="1">MSVLHTRFAERLGLRVDASTKTGIDGFGNGSATTAGTAPIKLTIGDGLTYLFTIAVCDFGPVGFHAILGMDFLEMAGMIIDTVKREIQLPDDNWIPLVLQPIKYRRGRVDTVKTPRQIQLQPGDSVCIKLPSPRPGLTNAPEFWVQRGARWVTTAIVDDSGTPRSYRVTNVGDSLLVLPPHSVVGAISAPGDRPNDHTMVRTNSLRYKEWKAAAYEGSYSTRYQRMRDQVMAGDCPKMPYTDRPPRAPPEALLTQSGIRRLTQTEADTRPGDVDTRKDFTGRDGHEAVLVDDTTKQESNFSYFVTEHHQGLPPPSIFTLQAPPPDLDQKTLPLEVVIREGVDLTSEEMESQLALIPEIPPQVPFDMDQLDYGEVGQSEEERQQMRKVLDKYKAYFIRSGNGLPPPARGTVCDIDVGSAKPIAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XV53</accession>
    <name>A0A6G0XV53_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_001027</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XV53"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004402"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20540">
        <property type="entry name" value="CYCLIN_CCNY_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14248">
        <property type="entry name" value="CYCLIN Y, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="18"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0744553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="470" mass="53152" checksum="DD97292D5928886A" modified="2020-08-12" version="1">MGDVMKNHQVPNNAAVEWKVAHDPRSGRPYYYHPVTRETSWKKPASLVKKEKDAARQFFRMMEKNIKSKLLRIPAEKEPTPSEEQSTTPPPMTAPPGRPPKMSAQPRLFRTLSAKEDMFDAAMNSTPRSTTLARTEMPSPIAEDLMSLDSSYYASRQSDLGLPTKAASFQTTSWSVPPQPQRMRSNSTNSIFVRMGTMNKPDQTSTFFCVATVLHGHIVEAQANPLPLDQRFAGFQSPQAYSSVMPTVDGIVQFMTQIYRTAQMESECIIMGLIYVERLLQATAGKGLQLRTSNWEAIVFCSMVMASKVWDDLSMCNADFSKIFQGQFPLRRINALELLYLSAVEYNVRVSAASYAKYYFHLRSIYKSLKLGQLSAFDSNTPLNLDGARKMQVISEDYEERLKLLPPPLRRRSRTISSQVLSDRIFDEEYRYSDLTAPPASLEQLVHMEVKSAGGASPYKFSGWSKRHSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XV58</accession>
    <name>A0A6G0XV58_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_000906</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XV58"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021046"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026192003" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0744426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="408" mass="42176" checksum="E3B4EFB9E4E0180D" modified="2020-08-12" version="1">MRIAALLVGCALLLAPADARIRKLQADTTLAPTPDTTSTPTTVVSPAPTPSPTSKPTTTATTTSGPTTSAPTTVSPTTTSAPKTTTSTSTSAPTTAAPSTQAPQTTQAPQSSPSTAKTSTQAPSSTASPTSTQKPASTISSTDATAAPVATDDSSSSSSSSSSSTFTTAKPTTTATSSSTSEDGTSTGTYVGIGVGGIVGLAVIGAGVYFMLQRQKDEDDDPMSPDFKDSMGKSSLYGAPPGPATVDSIPPPRSYEQPVSAPVVTQQPAPIQPTNPSPVPVLSTPAVEYHNIQANATIMNTFRSADEDMDFDRPSEVSIGESIDNGNAWTRAMNKQHEVIIDDVETNSYNSANHSAFNDEFDDSQSEGSRASSFMTRNTFQSHMSSDMDHHDFPSHNESTAERGSYEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XVA0</accession>
    <name>A0A6G0XVA0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_000960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XVA0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002909"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="28"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0744484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="128" mass="14620" checksum="1CE3E2B48B38D08B" modified="2020-08-12" version="1">MNSCDCIDLLLDELPNNFSQLDLPVDFIFQQDNAPIHKAKKVLNFLDENAVTTLEHPPQSPDLNPIEHVWAWIGLRIRDCPPTSKEGLKRRICRLWDEIPLDFIQKLIKSMPNRLADVIGAKGGSTKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XVY7</accession>
    <name>A0A6G0XVY7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="8">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_001143</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="8">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="8"/>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XVY7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018525"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="12">
        <location>
            <begin position="180"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="212"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="523"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="68"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="361"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="403"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="479"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="180"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="99"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="135"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="147"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="161"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="369"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="407"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="480"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0744686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="792" mass="88335" checksum="1F84155FF05EE139" modified="2020-08-12" version="1">MMILEWLEQIWHKLNMVKKPKQQPKKQGAPSKPKTKGWQRVDLEDFEIEGFEDGNAFELEELTEYTLEDDGFGGRILKAAAPTPGKKNKGAKPAKSPAVKTSTSKPSQESNAVDETTDENEPTDPEDDINNEAKGKKKKKKGKKNKTPQSNDATTEATTSNDEEKEPDDQPADEDVPVLPEWAKFNLHPTLNASLTRLGFTSPTNIQALTLVPAMIDHRDVVGAAPTGSGKTLAFGMPVLHHLLSKPENRGKCRALILTPTRELAMQIVEHLQALVPDKRRVGIVALVGGMAVQKQLRQLSYHPEVVVATPGRLWEVMEAGETKHFDALNKDLQFLIVDEADRMLQQGSFPQLQQIFERVNKGKADAPTNEDDKEDGDDDENDGSVAPAEASLIMLDDVLKQQDGKADDDDDEEAEEAPAPPETQKNFVRQTFLFSATMTLKNAGRFQTKKMKNPTALTMLETIMKRIGLRGKPAVVDLSAKEARTKDDKSRGDDKPRGSEVTLPAGLELAQVECLDVHRNNVLYYFLTQYPGRTIVFLNAISGVRKLAGVLQLLKLPVFALHAEMQQKQRLKKLEQFRAHDKGILIATDVAARGLDIPSVEYVVHYHIPRSAETFVHRSGRTARASQEGLSLSFVAPIDAKYHAQICSVLHRPSGFSVFPVDHKFLPVIKERVKLAEQIFASDNSDNKQNAEATWFSQMAQAADLPFDEDEMAAVAPAKKDKHKTQALRANLHHLLLEPLRPIGSKRKFYKLHEDLKSNKISTDGEYSTRDATADLMQKSKKHSLKRFRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XW00</accession>
    <name>A0A6G0XW00_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_001092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XW00"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001602"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0744628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="700" mass="79187" checksum="03CFC83A1AF59357" modified="2020-08-12" version="1">MSQVSPTQLFEKTKLVSQQNLTYQHLQRPRLPVAWANRFVAFFDLLCWLLLVCLMVLQVINAFLTQSMIDTTLIYGARPTESSLELIPGNNDDPYIDRAMACVLVGRVYKSMTLDEALNGGATIRNFANITADSYTVMVRQDPQTTMRDTYAYYNPICSAIALTMNGIAHACADQGYLPVTDSLRINVGTDATRTTELTNALPILIMPYYDNGADARYGIPGYDGVFCSFMLYNQYLGPGSFYQLTVINRTDFDVKTRLWLNEPRGTWQNGWYTFPDGIKRYYSHMQSDLRPKDYPGGLGISSVVYDALTHMIADCETDPTRCESQLRFVWENVVVHNAIALWAECVCIQDKDRKGFVWYSVENQNVVTFRGGLSAVLANLSVFVVLFQWAIKLLAAWRGYLYGSADWHGCGIGILSCSDSFVWLPVLLAPGYKLIFLCFWASCIQFEGDLLVVCDAWFILYPALAQFVLLYFAVLNWLGKALRIRVSDRLFGPVLLALCLAHYLRDVTFINSGPSMGFSGRAQTLFFVASYREAYIYEVMFTKALIIGGNVKPILIAKLILLGLPLLELFVYSDRVGPNCKYQPPGGKPTQIESTLAIQANRCGGLGKSTMYTSTGLNGYEVLRLGYMLYGKNNILSFDNYMVAIACYPSYIINETFNQRILTLEIFSRPFAIKLMMFRWNNPRFALIWWFQVQSVDMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XWQ2</accession>
    <name>A0A6G0XWQ2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein Mpv17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_000577</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000003">
        <property type="protein sequence ID" value="KAF0744994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XWQ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014742"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0744994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="22745" checksum="206B918AAE5D5CF1" modified="2020-08-12" version="1">MMLRRLLRRFSTTKPPQTPPRSSAWAAYSRLLARYPLLTKTLSSGAIAGIGDVVSQLGIEDAETFDVRRLVIFTAVGGVYIAPLLHVSYGLLNRMFVGVSTKVVLQRVAVDQFVLTPTFFVSYFALMQTLAADDVTIEEKLRQEWWPTVQTNWVVWVPAMWINFRYIALPYQVLFSNVVSLFWNAYMSFVSHRAIKASTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XXT7</accession>
    <name>A0A6G0XXT7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycosyltransferase family 28 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_000346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XXT7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018101"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF13">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyltransferase family 28 N-terminal" evidence="1">
        <location>
            <begin position="63"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0745318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="157" mass="17623" checksum="4582CBABFE6F7379" modified="2020-08-12" version="1">MWRTVINHRQILQKTSRGTFCMASPDSNIRSKQSDAFAKSRLSRVDMVEDRWEEMDVPFSMSIAMLVVGLASDVEAFVAIAKSLLRDGHRVRLAAANRFEAFVESHGVEYVPLEGNPTTGQDRLAALSPWEVLFGQDKMQNSPWNNDDAFCSICLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XXY4</accession>
    <name>A0A6G0XXY4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase</fullName>
            <ecNumber evidence="11">2.7.4.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Ae201684_000064</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:37459"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:74946"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:37460"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:10276"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58628"/>
            <dbReference type="ChEBI" id="CHEBI:77983"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:10277"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
            <location evidence="1 11">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the histidine acid phosphatase family. VIP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.24" evidence="11"/>
    <dbReference type="EMBL" id="VJMJ01000001">
        <property type="protein sequence ID" value="KAF0745611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XXY4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011485"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033857">
        <property type="term" value="F:5-diphosphoinositol pentakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000828">
        <property type="term" value="F:inositol hexakisphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006020">
        <property type="term" value="P:inositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000036">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013651">
        <property type="entry name" value="ATP-grasp_RimK-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037446">
        <property type="entry name" value="His_Pase_VIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040557">
        <property type="entry name" value="VIP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750">
        <property type="entry name" value="DIPHOSPHOINOSITOL PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750:SF9">
        <property type="entry name" value="INOSITOL HEXAKISPHOSPHATE AND DIPHOSPHOINOSITOL-PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18086">
        <property type="entry name" value="PPIP5K2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08443">
        <property type="entry name" value="RimK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="VIP1 N-terminal" evidence="15">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp fold RimK-type" evidence="14">
        <location>
            <begin position="181"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="458"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="705"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="642"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="463"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="739"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF0745611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1026" mass="116163" checksum="E37491EB0EB47A50" modified="2020-08-12" version="1">MTEILSRLPKTTFEIVVFGDDMILNHSVEEWPLCDALIAFFSTGFPLDKAMDYVELRRPIVVNELSKQNLLMDRRDVYRILEEHDIPTPRHIFVNRDGYNGDAEDPEGFVEGEDFVEMNGVRIHKPFVEKPVNGENHNIYIYYPTNAGGGCKHLFRKIGNRSSEFHPNVINVRREPGQSYIYEEFISTQGTDVKVYTVGPNYAHAEARKSPVLDGKVMRDAHGKEIRYPVILSTHEKEIAYKVCRAFGQTVCGFDILRVGNESFVCDVNGWSFVKNSPKYYDDCSVLLQQYLERALSGLEDPYGDSSSPSHRVLGNSSSMSLLDLMDGADNDEAILPERAVSYHDPLDNGGQEEELRCVLAVIRHGDRTPKQKMKMLVTHQRFLEFYEERVGVGKKKDLKIKTIKDLEELLIVSKELIEVYEAMDDPDKEKLKGVCTLRDVLERWQLCGINRKVQMKPRGWSTDDDVSSEGKGDDDDESKAQEKVGRVTQLLVIVKWGGDLTHSGIQQAETLGQHFRQIMYPGGDGGLLRLHSTYRHDLKIYTSDEGRVQKTAASFAKGLLELEGDIVPILVSLVLKSKDADSMLDQSGSSAQEMILAVKERLHNILHRGDDCGLLRTNSDSRLVRSVAAALDVVEQPMKKMERMHKLLNSLREQLTKLLDNEATAKSENVIAATEFEREQQAWAYTPPALVRQGSETSVASCLELEPDNAPPTPTHRTTVSSAGVRPQKAAEHMMQNKAKSPRNQHPSNKKREPCGRETLEMMRERWAKLYRDFYSKKHNTYDLSKIPDIHDCIRYDAMHNAHLYLSGVRELLDISASLAHALVPQEYGIDAHEKLHIGTNMCRSLLKKVRDDLDLARGINITHRLNPAFATKDNLIKSTHRSVRTRLYFTSESHLHTLLNVLRHSVTGIEDDAPISCDAVKLIEDIPELCYMTHIVVRVFERGWYDSMDPKRFRVELSLSPGATGDPLTEFTPQKPLPVAPLQVISREGLTCQEFQDYICNVIAYGTTSKPPQHSPINSTKSDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XYA2</accession>
    <name>A0A6G0XYA2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_000471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XYA2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017271"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0745455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="310" mass="34866" checksum="82B459EED55E3291" modified="2020-08-12" version="1">MEFFPTKTDLGKEEAATEPPSRQENGAENYRNLVINAGLLTPDGNSSVRVDTFDELKLKVKRLALWSGFEVKLDGRSDKRRRWKCTSSQMCPFRVTGNMNRHGIFVKTHLQHNHGYHVREETNKRFTTATSHELACIVRRSDLYETHGPDLVDVTGQQISDCIYDLTGFHINQMRASRIKRMLMDDPDRFLGSNESPETVNSTPAESAAVNPPAEAKDDSSSGNPHDVVWECFVFVANDPHVLGTMGMANVKKMVAKFKSDAHKATLRAICRMSCPDPSAPLSVLSNRPIATKFLECYQRQVDLGFFNDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W3H6</accession>
    <name>A0A6G0W3H6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_019065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000384">
        <property type="protein sequence ID" value="KAF0721571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W3H6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005899"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0721571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="468" mass="52845" checksum="EB829DC8F58F7ED8" modified="2020-08-12" version="1">MPGPVWNTIGKRLAEQWLAISSSPYFVTTCMKSPKEDTGWVALVFLAGYDAFPLCQPPSGPQEIAGMAMVETTVREEYPNGAYMLTLFADKTMKESAVYPNSDDDMDLMIVNLNRSLISTDGVVCTDTLGITRVRNASPLGNHYKATSYTYEVVVDITNRVDSSLKWWNVGRQSKKAITITWEIGHHVANWPELLALQLSCVVVGFFLLTSDFYLTITGLRGFLKRKPVLTYDLSIGMERRKVPMFLWVFANIPSILYADVARMYEGSNQVLWFFVCVYIPGLFVCSTYMAISIIQFVPSPFKHVVPFSSRIMAHGIFFTVMIVWMIQYANLMDKYEHASFHLGFNISGVVRPSGACSIDGVEEVFTTMAPATIMITITSIVVAIVVPSYQHKVKHGTYLVNLEWTESNRFLTHGGMPNWITGLPLEEEMMIKIGNKLFCKPSTPWICYNHISQYSWQCVTVRFTKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W448</accession>
    <name>A0A6G0W448_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_018928</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000367">
        <property type="protein sequence ID" value="KAF0721750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W448"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020436"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0721750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="299" mass="33274" checksum="1258C5AA4F0D89AE" modified="2020-08-12" version="1">MKPQWIWNVILVSVVAGLVGYMLPLLLKETPDVRRANLAATQSELVKRGQAVKQQYAQLKNELGEYQTLVSDIWKISAVRKMREDQLIAESHEHLVAIKDLMQERRASLESLMAETTQGLRDAIGVLREKTARRTTTVPDVVAPVDDPIEQNTPTTTVISPKVPPPVQQKPQEINVKPLKPAAKPAPVPSPPPLGPAPPVVVSADIVKSNEFPISFTNAVLGFVIILIVLVSFSMLNEYRTADPSGGLFSPRRPLRPVVDEEPESAGGFFDMLYPHERVEEATPIRRSRRLDRKPAMFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W4U4</accession>
    <name>A0A6G0W4U4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_019137</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000413">
        <property type="protein sequence ID" value="KAF0721436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W4U4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004502"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000009">
        <property type="entry name" value="Probable E3 ubiquitin-protein ligase HECTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF440">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NEDD-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="8">
        <location>
            <begin position="290"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0721436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="629" mass="71110" checksum="956D5127E22D85BB" modified="2020-08-12" version="1">MDDNKNTNDSMTPVLFLVISVFVLIACILLLKVLIKNIPSSSLTEPLLGANARPFMPGLKREDIEHLLLDAQRWECSICAFYNLNEQQLHCVLCGTPKGYRLIEDKMEEVPMPARSASSSFLNNHRKGSTLLRFTAHIVTAVFEHVLTPQDLNALQRSARMRKQWTRSTGSLPWTRHFVHTSWLPDAFIIQLSSGHSSCPLSDDDSSTGLISWLPIDTLTHHTTVLGTAVAPGTWNSLVELARLPFSLKFAWFLSQLSELMTPYSTLHVHCKVERNRLLDQAMENLTTIKEEALCATMRFEFVGEQARDAGAVQREWYVLVAQALFRETDDNSGLFVMVNREDQTYFINPHASHQFGDFTFRAVGRFVGRALLDGQMLPLHLSPVLLKALLGVPLSLDDVEHFDPVVYKSLIYVATHSNVEDLALTFSATEEIRGGLVEEVDLVENGRSISVMEDNKAQYIQRMVKYLLFDRVATQLEAMIQGLYDIVPPELLVPFDHKEFELILCGLCEIDVQDWKRSTVTSSNLKNHRALVWFWEIVEAMSQADQAKLLQYSTGSARVPVQGFKGLTSYDGKICYFTLRGVPYTTGRYPAIHACYNRIDLPLYPTKELMEEALKMVLLSDPTGFTIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W5B8</accession>
    <name>A0A6G0W5B8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_019016</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000375">
        <property type="protein sequence ID" value="KAF0721644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W5B8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014010"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0721644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="177" mass="19603" checksum="35A635F393E389D8" modified="2020-08-12" version="1">MELNAPLLAAAVASSDDQAKVNVKMADDKVIVAPRITIILKTRVGQFEADEEYFVIDLDDRWDLILGMRWLEKHQPRIDWATKTMHKMPQEAMGSPLGVMSNELTPDSNRVSQFTARDMATEPTCLLHPPDFDNDGIGGAMSSEPDDAWDVNHDLPSQVLAAPDSTDGPMALLTMQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W613</accession>
    <name>A0A6G0W613_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Core-binding (CB) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_018398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000333">
        <property type="protein sequence ID" value="KAF0722454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W613"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014653"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0722454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="106" mass="12018" checksum="EC01272814E46F57" modified="2020-08-12" version="1">MSCNNDGIRRWEAGDDVVEMRLSTNTRYQYNTILRRLQSWLEMNHPACVEGGNIRLPLDPRLCKLFLSHESTAVGKNRTSKTKFKSSSAISGCKSAIAHLYKESKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W6W9</accession>
    <name>A0A6G0W6W9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ae201684_018058</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000319">
        <property type="protein sequence ID" value="KAF0722983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W6W9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010226"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF254">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="302"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="526"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="653"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="680"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="711"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="758"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="14">
        <location>
            <begin position="95"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="14">
        <location>
            <begin position="647"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="485"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="977"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="455"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="983"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1001"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1014"/>
            <end position="1024"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF0722983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1097" mass="123851" checksum="D692489F4D692C7F" modified="2020-08-12" version="1">MVAPDDEVVPVYTSKRHSRRQSRPRRGSHAITDIVNTAMENELASLAQSTDMTPQIDKLATFQARIREMDAARRGGWRRRVRKVLKNPLATRRGQFYHYGMLATIICNFFPMMLETLDGPANGGTSPAYPFLPSSTVYYAMDVFFTAIFALDLGLKLVTAKHQRKFWRRLDTWIDVLGILPLFGTSFMYFVLGWGQPRRKNVEGYLKLLRLFRIIRVTYMLQHVDGIKVLKTTFVECLPPLRITLFFLGVFVMVFATMLFYAEPCYDASACPFTDIFNAGYFAMVTVTTVGYGDQLPNLDNIIAVLLCASIMIIGALYLAMPLAIIGLKYELTWLRFEIKQTSKSRMLTRARSTMRSLRHLMTTTGLPSDAIHPTVHRVYIEFLGFTKEALQLETMISAYMAIPPKEIFAGVNHRDHNEALERLHVACKHVIVTYQKFTHDMRAFEPVQLPPAEPRGRTQDHRPSSLTSKASDALFRAKRAIQGGGPAYAPSSTRQEDAERRPPPSLRRRLRRILERSSESTAGQIVHRLVFGMVVSSVLVFYAETMPEFQAFGPASLLCRRGIQAYCSRYGSNVGTDPGCFVWLNATTVSSTPLSFGDDSCTSDGCFGSGYNFGSTTTPRDCSTLFSRPSKSCKLRQCQPDHVPIADMTTAWIVPETLFAAFFTLELALRLYATKRRSLFLQSTGTWLNVGAIVPYYVEVLASITDGRDPLFAILPTFPTLLTILPVLKMLRVLKLGQHFKASVVLSRTAILAYRRLLIPLFFLFLGCVSAGAIFFEIERGTQCRAHVPCPWWGRDIMTVDLSKSFPWGKRIQVQVDKLTIITDMWRSTWLSIATFTTVGYGDMKPRTPFGRLFDICAMIFGSCYTAMPLSLIGGQFYSCYEQFLKKQKQSQSGREAPQPKPIDPLHHKRPVGVLDLEAIDMLKKCSVVVLLLDEMMQNMVKINQLSPHPVAFGTIVRTSQSPHGHKLEHQLSMYQPPSRDLASHRPPERNTETGVLRRVSNSSNSLFGKSQHRVEPRESVVSRPRVLDVKELKESDEHTDDDKMQRLTHLRGLIQTASTHMTTILLQLTRVMEQVMVYDDPGDDDDLDDNDSNGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W766</accession>
    <name>A0A6G0W766_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_018026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000319">
        <property type="protein sequence ID" value="KAF0722950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W766"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001361"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0722950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="137" mass="14887" checksum="A3EE669015A06774" modified="2020-08-12" version="1">MRPIQKLHQVFMMLCSLVDMAAAGYLFATASYNFESNLRYTVAQLVVFAALFGLSLLLFLATSFGASKPLRWFGIMGSFTGSGLYVIYLALLVSFYEGGSFGTFASISLGCVGVLSILLGLAWHEKDTSSYYGLLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W8B1</accession>
    <name>A0A6G0W8B1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RCC1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_017757</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000310">
        <property type="protein sequence ID" value="KAF0723318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W8B1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007940"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF408">
        <property type="entry name" value="OS09G0560450 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="36"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="RCC1-like" evidence="4">
        <location>
            <begin position="38"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="86"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="139"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="189"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="241"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="294"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="346"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0723318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="399" mass="42317" checksum="8EF198E63AD5BBE7" modified="2020-08-12" version="1">MYTRLATRTSLPFLAAAFSSSYAHSKGAAPPGTKPRQAYSWGSNAFGQLGHGHEKDISLPQAIKLDHPPQSVACGGNSSAIVTQDGHVYTFGAGGNARLGHGDALDTPNQSTPQLLQVPGVIQKVDIGEYHMAALTTDKRLFTWGRDGAPQLGHANANRGYPNEVEELRGQVHDIACGRQQTIAITTDGKIYVWGLAHEGSLGLGDRTNVNRPKQLNALAKEFFIQAACGREYTLALTKDHKVYAWGANDYGQLGVAGAMRYQRSPVPVLALNDLQVVQLAAGDYHSAALTASGEVYTWGAGKDGQLGLGTNDDRNVPRKIAELDGIKIVQVACGGGHTACIAEDGSLWVFGRGRSGQLGRGDQLESIAAARNSPIQVKLPTHQPATHVSCGSDHTMAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WB15</accession>
    <name>A0A6G0WB15_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acidic fibroblast growth factor intracellular-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_016849</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000270">
        <property type="protein sequence ID" value="KAF0724441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WB15"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000372"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008614">
        <property type="entry name" value="FIBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13223">
        <property type="entry name" value="ACIDIC FIBROBLAST GROWTH FACTOR INTRACELLULAR BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13223:SF2">
        <property type="entry name" value="ACIDIC FIBROBLAST GROWTH FACTOR INTRACELLULAR-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05427">
        <property type="entry name" value="FIBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0724441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="421" mass="48319" checksum="21A4A49952E02921" modified="2020-08-12" version="1">MREIFDTFLTDPVLLSEDVYALWLEGQNTSTALDIRFRSYAHPAPTAPFDFVDASEHDQLRDLIWRDTVDQYRLFEKLESYLMQPSLLRTQLLFQIPPWQQQEMTEKYFGFDGAVVRRLLGKKLSSRAQKDLDEVSEQSLRTLKNCRRQFENLRRIYALLEEKNFQGSMCRAICEHFLISEKLAAKYACLVFLIHGRFEVHPSHKTVGFLTWNDLQFFSSLLMGHWVAPSVKRSQLLDSQKPNRASTSILTQGSSLECLRFRPRWVEKAEPSDDSKAQQEWPSLAYLEARVTPLSARYSIGVDLNQQMTNSLRDLKAHFLNDVETLTEYRNVVMATLQVKLKGEQLEHLGMKMLPIARGLLTIGAGLSQPKELKDLIEDLIDDVGIVFKDSKLALRDIDLVFSALIDSLGSIDVCKLGIIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WBP1</accession>
    <name>A0A6G0WBP1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LNR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_016575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000261">
        <property type="protein sequence ID" value="KAF0724826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WBP1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001804"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0724826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="686" mass="76219" checksum="D1A7EE6DBC3E74E0" modified="2020-08-12" version="1">MGATASSLDLICHHVDLYLCYLTFFSVICQHLHLSLAPRKKFEVIDKALGGNAVKMINLKAIMNVSWLASTENAISTGASSLWWSVDVLMVSYPSNYIYPSRTMTAAVHCLRAVEGPRLPPKKISKWLYWFILSFAILKHFVTALYLAAQIIIMVLADASQLRTARAYAINAVIAVFAIVLCLHLGSLVKYITSWKRQKHGKTIAKASRLGSFLVQIRYMATSPRLVLGFNTIELICQSYEAYQLSKLLVDPRLVILYVILVALHAIVVPSFVCMSHTTKTHQLLLGWASSLLSFGLCCLVHFYGLILPLLYYFLVDHWLSRSPSWNARYISYIRYNFVTSLEELVAKTVVQLGSIIALWRLVANVNVAISVRYNTDHGSSSASLRRFTNKRLLTVYWICCIGWGLVLLSGLIGAFSPPCPAVCAARATPLWSRQCHCSYVHVNCHALGLPLDSDVDSLLRADELGSDLLVLQISRFDLSNGISTTTLGQFQSLSFMAIKFTNISSWEATLPSSITFIVVSYGRLSQVPSALQNAPLPPAWQIINRLYLVNLSLSVLPRLDTLDLHYITLAQNNFPVLPPIVNDAKSHNIYVDLSGNSLLHSPWSLLKPGRTVYLCGNPDEIPPDSLDPKLRASYLAKESAMCGKPCVPSCFPHMVGDHECQLVCFTKGCRYDGGDCDEYGLDKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WBQ9</accession>
    <name>A0A6G0WBQ9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_016752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000266">
        <property type="protein sequence ID" value="KAF0724689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WBQ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017969"/>
    <dbReference type="OrthoDB" id="70919at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010530">
        <property type="entry name" value="B12D"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06522">
        <property type="entry name" value="B12D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0724689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="98" mass="10975" checksum="8033D737EF42CEF0" modified="2020-08-12" version="1">MASRVTRSVVKTWFSDPATYPIIGIMAFAASMATFEGVRYLTSSPDVAFSKDKRTKLDHRSSEEGSAFRSHRISAATLKANPITREAEYQAFRVRNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WC88</accession>
    <name>A0A6G0WC88_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_016521</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000256">
        <property type="protein sequence ID" value="KAF0724901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WC88"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002632"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0724901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="89" mass="10251" checksum="FDDB55B997520274" modified="2020-08-12" version="1">MVVVPFWHLSWHCWKKIQGAERAAALDMAATKRACALQLEDLHVEQSRKVADLEQTMASQVDALATELTKLKEQEEYDATMLARYMERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WCL2</accession>
    <name>A0A6G0WCL2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_016921</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS35L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000272">
        <property type="protein sequence ID" value="KAF0724379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WCL2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020736"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029705">
        <property type="entry name" value="VPS35L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13673">
        <property type="entry name" value="ESOPHAGEAL CANCER ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13673:SF0">
        <property type="entry name" value="VPS35 ENDOSOMAL PROTEIN-SORTING FACTOR-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="873"/>
            <end position="900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0724379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="999" mass="112737" checksum="22FFF22D0323B31F" modified="2020-08-12" version="1">MPMSLDVPRKASWHVGAKKMTLSVSNAIRDAKLLPTKTHPLRYDEGRAGENTPVLSPVDQTPPTLTSASVTELRAGELDPLSALMSSFEIEPVKKTYTNDIKQDAKAFDDTRNDYLDEWTAQKHAIFHAFAAEKFQIKVHANEDEGERVRFVDDPNPVMQRARARLELLEKKEEVESTTVEISQGEYINRIKALQNDFLNAWHEDQKVLALRITIKCIKLLGDSSFPKFYPCMFVLVSDVLDCFGTHVFNRIKAKADEQNPLSNNFTSADVSIEAKETCRNWFYKTACIRELLPRIYTEIALLRCYRFLCDGEYPHIVLRLSNMIKGVADPTVALYTRTYLALASSRVLTGRDTAILQSMQDYMYIMHRFSVDKALDFYSQYSITEPELQAIHAPGVEWLMKNISIHATEKDVDSLLYQYKQYADNSMILEQILVAFPGALLAKHAMGLVQLIQQTTRKDVLFRRLSLKLVDAPPPPNEKLVFLNEVWGTITRLVDIQTYLKCAADFVALLVTHYSSREVVILLKDVVRHLNSAETMDAALYQALESIMEIIILEARRQTHYFTTIIPSNEFLTLLGMFQHSTNITLSKRLLHAFVRGKDKGLKLAVEGPHAAIVHILLSICIRVHDSLDYLSSSLETHEASLAISTFVLSLDVAAPGQEEGLLQMYVECRRVFYKLDKVKACLIRRVLWLSLLAEGRRSFVKGCLAYCHITIPSLSDSLERLQLMTLCAKIALASHCIPQMDAFVKAAIVLITELPSPTTMQRALGDDLEESSSFVSPEVYESHVIDAMSDLLSLLVVVPSVSPEDPLYFIHGFRNAIEKFPWRGTRIPILIQLVRFLATWVPDEPLPYTIGHVAANDVLFGGSPILQDSLNEQVSSVIEEITKHLQDLNQDKSQFNIQCDLVLDLVNALAASVELNAFSSTRLVKLMTGVAEHQAILHGKKSYLPRLMYLQDDITLYWRSTKAFLLRSAEYPPSALSPKDAASWHSLSHNLHGLQIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WES0</accession>
    <name>A0A6G0WES0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_015844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000233">
        <property type="protein sequence ID" value="KAF0725757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WES0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017360"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF317">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="451"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="480"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0725757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="587" mass="64904" checksum="FB25FCA10547ECB3" modified="2020-08-12" version="1">MACLLSYWRLTVPTKSETEIEAEQWLIVVAKRYGRFFVLPWIHFNRWHLVLVAFLNLMCVGSIFSTDFLDDAIDGFFLDKPANSVLSCQLVGVMTMGLSAALCGPFIESRGPRMSMAIATSLVVLGWIFAQLSVMVHVYMLLNIGIGVLVSAGYGFTLIVSVSTVQKWFPDLRGIVAGMCIAGMSGGTLLWLRLYADLFHRKSENIFVSVSQELDNDGLNHVFLLHGGVGFVVMLLATITLRTPPPNYAVNGMDVHCVPLNKAPTAAHVQNNYLDAGMTLVNYDAVGQNQSPTTECVYFAHVKALSLGQCIFSSDFFFLYVAFAASISPRVLLTFEMTEFMVEMVGTSIEQANSLLLDVNIAATLGSFVGPLLADLIIRIFYANPAYVRKMVFTALLLSQTIGLALLIKNVEDAESLKWPLYIVSFSSGGGCGLIPSFLADLFGLYNAGTMYGLITTTYSIGSLLMGIEHRHKEHHSSDHFQLLLILSIVGCVVMVLVRSSSMDRFYRGYQLTICDKIIIQRPSQRLIMEQKKAKSSDYASTDLMQESLGGLQPPGNNRLSDSTSPIFLIDPDYLQDLKRNHKFTNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WFS0</accession>
    <name>A0A6G0WFS0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_015952</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000237">
        <property type="protein sequence ID" value="KAF0725619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WFS0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017397"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0229">DNA integration</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="10">
        <location>
            <begin position="101"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0725619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="354" mass="40207" checksum="568B8003E26BC6D4" modified="2020-08-12" version="1">MTNNLYVLKTVMKHHRIWDVPPSQTFGQNTTIHAINSDKPNDDMLIAWHNKLNNTEMNQVAKIIKLIMDPKIDLATTTKVCPGCAQGQAKRVSYCHTHHHVAPTPLQSLNADLCGPIRPATIHNEAYTRMFIDQASRFIFGKLLKTKDDTILHLEELTSTVDGELPDSRISTLYSDGGGEYTSATFKAACLSRGIKQKFTNTDTPEENHLAAKGNEIVFNKIRVYITLPSSLWGYRFEYVIHVYNNTLQELLNHRTSYEVLYKKPSRLYKLKTFGCLAFKFVPKSHRPSKLSNPAIPCVFLGYATSQLGYTLWNPRDRTVTVSRSVMFDESKIRNADMFAIELFKSGRFLISKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WG17</accession>
    <name>A0A6G0WG17_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_016006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000239">
        <property type="protein sequence ID" value="KAF0725530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WG17"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001657"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0725530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="32282" checksum="9FC94BCBE01EC243" modified="2020-08-12" version="1">MLSCARSFHVLTYASILLFVVAIVFVILAMVAVGVSESQNMWTDVFRIVKAFSSDALLAVAILCLVASIVVASCPGSMPQARKWLFLVFGLGLCVSVAASVMGFVTSYHAKSWSGVAYPAEPDEVTIATGFNQMSCANRLCHAPATKFTSWFPNASSPRANNSAQGQRLCESMAAQDDTFQSYKTSCKACAEKDLDKYAAIWTWVDSQCPMNVTTDAFCGQVVLSTASNSSIVLSPYLKCRKALFNEWMYYAKRVAGGGTILAIAASIFLVVLCRSPNSTSRQPCPRERSEYYIPHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WGT3</accession>
    <name>A0A6G0WGT3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SPX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_015382</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000218">
        <property type="protein sequence ID" value="KAF0726360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WGT3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002503"/>
    <dbReference type="OrthoDB" id="6493944at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016036">
        <property type="term" value="P:cellular response to phosphate starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031142">
        <property type="entry name" value="SPX_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45978">
        <property type="entry name" value="SPX DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45978:SF7">
        <property type="entry name" value="SPX DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPX" evidence="2">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0726360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="241" mass="27713" checksum="95AF4FAFF99BD1C6" modified="2020-08-12" version="1">MKFGKELLNAVNQSNPEWGPFWMNYKALKKRIKAVVKTHNKATSPTRTSQDTDREVDLTQNQEEIDFFTELRDQLRKLACFYVAEEKRYLFRFQQLQSVLKEMKKKSEVDEIDAKRLMVACVHFYGECIQLENYAVTNYQGFSKILKKHDKMTGHNTRTKYMRKMVNQSPFANYPQLISILDGTERMFTEIPVGDSVMQTAMYMAMMGQSGPRRDTTNSAHAASLAAASSQPGSSNMEVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WIQ5</accession>
    <name>A0A6G0WIQ5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_014843</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000202">
        <property type="protein sequence ID" value="KAF0727107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WIQ5"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033565">
        <property type="term" value="C:ESCRT-0 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47794">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47794:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="5">
        <location>
            <begin position="8"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0727107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="94" mass="10824" checksum="1E6AE42AF1DE8BD6" modified="2020-08-12" version="1">MVPGRPRMQESNSCFHCLKQFKLHRPRHHCRNCGCSCCGPCSAPHKIRLPWFGYKAPQRICAGCAHELGVATSWTLKDYVLRGWMTKAHKTKWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WIQ6</accession>
    <name>A0A6G0WIQ6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_014838</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000202">
        <property type="protein sequence ID" value="KAF0727101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WIQ6"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0727101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="80" mass="9159" checksum="82284B7743F5146C" modified="2020-08-12" version="1">MDCKNRAHQARGSIVTTNLDLTNYFDREIQCQVDMPGCFVSIENIGVYRIAFVKMIASAFCYQCSRDIQGTTGNYCRSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJ25</accession>
    <name>A0A6G0WJ25_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_014727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000200">
        <property type="protein sequence ID" value="KAF0727198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJ25"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000112"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0727198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="184" mass="21024" checksum="FF8BB2D232291A9F" modified="2020-08-12" version="1">MNSFAILQELENFFVEEDHHGNKFLSLQIRVPLGRESSHQRQQWDAPPRHHDHHNNHRGPSMHPNRGGGCGNFQRDIRRGPSQHPNRRGPSMHPNNRGPSMHPSKRGPSMHPSKRGPSMHPNRGQSRHPGHRDKSMAPNRPNGMNPRARSRSHYGPRDDNSYNAHSKSSNDVKAEPKSSDSTWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJJ6</accession>
    <name>A0A6G0WJJ6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_014645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000198">
        <property type="protein sequence ID" value="KAF0727387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJJ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017214"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0727387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="131" mass="15115" checksum="B9ABD59F2BBD4B5C" modified="2020-08-12" version="1">MGRNQFKPINDTQAHNYLVGHVDRTFTVIIFKWGNRINSAADLQEFQRQCVAPQVQDRAGAAAEALHQQMVESLNTAWEGVYTAYEAIWRMWASHILKSPTHEHEALISRHPPMQMIQSLLPDIDNKERHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJP8</accession>
    <name>A0A6G0WJP8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ae201684_014486</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ING family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000194">
        <property type="protein sequence ID" value="KAF0727464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJP8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021649"/>
    <dbReference type="OrthoDB" id="5411773at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038291">
        <property type="entry name" value="SAP30_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025718">
        <property type="entry name" value="SAP30_Sin3-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF103">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13867">
        <property type="entry name" value="SAP30_Sin3_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="13">
        <location>
            <begin position="202"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="124"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="144"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="159"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="270"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="9">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="9">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="9">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="9">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF0727464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="281" mass="31548" checksum="722C1758D84D94B7" modified="2020-08-12" version="1">MTTLDMPMTSVPLGEKSHVASYSDRNLDNLDTKSKATKSSNDKVKLDRSPVNANKIVYPPRLLVDFNSLHIDALNKYVAFYSIPVREEYTKDDIAALVARHFDCSLEVEEDESILSFVTRVRNGEKTTRTRPPAPKNTQASKKVAKEESKTSTKRAREAEEEDGDKDEEVEAAQPPPPKKSTKSSNKSSKDKSSDKNNDDNELYCVCNLPGYGAMIACDGKQCPNPSQWYHLECVGFSDGQHPDTWLCPECDPKAFATVQQKKKKKNRNKVPEKSKDSSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WKK7</accession>
    <name>A0A6G0WKK7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleotide-diphospho-sugar transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_014217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000188">
        <property type="protein sequence ID" value="KAF0727780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WKK7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006644"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044845">
        <property type="entry name" value="HPAT/SRGT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31485">
        <property type="entry name" value="PEPTIDYL SERINE ALPHA-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31485:SF7">
        <property type="entry name" value="PEPTIDYL SERINE ALPHA-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026135317" description="Nucleotide-diphospho-sugar transferase domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0727780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="448" mass="51313" checksum="014CE258AABEF69D" modified="2020-08-12" version="1">MSTPQWPWRAALVLAAVAVVLVNGDNSTSDLAVTIQPPLPGYDEKTHVHLVFSTGCDQKLRQFLSSSLQLSLTRVSHVGPLTQIISGCGEQQRAAVEQEPTFYSDFRLHFTKDYAQYTSPNFSEHYTAYNKPFGMRDFLHNAAKKDNLAVAFIDVDYMLFKPVLINQGLQWGKYYQNTTVRRAEDINDTVKDGIALAQNMKAFLGGRWFNDVNRTILNSVCDGLPCKNVSSPDAFEYFEPAGTPYILTRNDWLRMIDNYCDFTVRGRQLQKDWMVEMYAYGAAVANHNIRHTLVKHLGPATPEFQNTEYWQFLDDSMENPCEDLYEPILPADPPVGIHYAMYYGLPGDINQGYMYYKYRIPSDILQCDSLFFKLPPATEWTSITKDFAGDDKKIYWKRHAVWLECTLIKYGNQVLHALKSKLCPRGYNAHQEIVLHAYDTPRTAFPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WKL1</accession>
    <name>A0A6G0WKL1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_014228</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000188">
        <property type="protein sequence ID" value="KAF0727791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WKL1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019130"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0727791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="466" mass="52813" checksum="803CED926A7F8EBF" modified="2020-08-12" version="1">MELVDSALSCDRLLQVQDDTGKDTKVDMTYRESHIGYVLPFLTIPELFRVTLVNKEIEAFCEQEWKVRVKERFGALRFAPSSYRRVFAMRRHFERQVASSNVSARVYLMNTNGDTTFFRIDSGKPIMCSRERAVVYNRCERMFDLSLRINRSIQEISALIGMVSLDEARDLLNEHINLMASVAALRGSLLFESELFQVFPAPVLLDSNVLLRGTHSLEPPFRGVPLMMQTWVSLNGVIFRPLSIPQLLHTHGATNPDQTSRAYSTLRFHELSGMTIDVDDNSVRYNLTPDSICLNTLASNAYLLYLFNPTTFRPLEWTYEATLSIESRLHLLPVQREGVFLNQPSCALRVFFSYGKIVQDDGEDERQPLGIACSSGDASFAFSLVATNRVSNAKKVIVSKTMNIRLPAMSDDSTSRPEKLERHVQLGRDAVICYNFDATNHLQYVELAIGFEPLLDVLGIAPFLMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WKM1</accession>
    <name>A0A6G0WKM1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_014237</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000188">
        <property type="protein sequence ID" value="KAF0727801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WKM1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019121"/>
    <dbReference type="OrthoDB" id="541276at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF91">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PLK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="6"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0727801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="288" mass="32578" checksum="C07A51F5B92DAACA" modified="2020-08-12" version="1">MSLAQYTIVKQLAPAIYGRVLLCVDNATASTVAVKCMSTQAIAKKRSLKGNHAVHEDVVMEKKVMRQLSSRQHPYILQLLKDFQENGQDHLVLEYCARGELFDVVCNCPTGRLSLTQTQEYFHQIVSAVSFMHAQGLAHCDLSLENVLVNSRGECKLCDFGLAADLHKVRTNAVGKFFYMAPEMYKQSYFAPGPADMWSLGIMLFIMITGTPLFKKANDDDDTFEYFKVNGLRCMLMWWQMDHLFPEPVMEMLEKLLEIDPVKRMTMKELVCTSFVHEAGNNPATDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WMG6</accession>
    <name>A0A6G0WMG6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_013710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000176">
        <property type="protein sequence ID" value="KAF0728526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WMG6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010024"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="54"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0728526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="496" mass="55767" checksum="46DD1F8E04EA613F" modified="2020-08-12" version="1">MQIAQGGYVALVMTIADPKTPHEALSGPNATRWREAMQAEIDNLIEKLYLAVVKYDSKGDVEKFKARLVARGFSQQYGVDYTETYSPVIKQQTVRLILALGTFFGEEIEHMDVPQAYVKAGQDTDIYMEIPAMSLYGLKQSGRMWHTDIDATLLEIGLSKSLLDPCIYYNWSTHGLTVLGLYVDDIIVFSQDHEYLDAIRLRLEQRYQVKSLGDVKRILGINVHRKGGALFLEQTKLIEELLENNDMKDCHPQSSPLPLDHKVTEDGQPSAMSSSKMREIIGSLQWLAGCTRPDVAFATSLLSRFAPNEHHEHAIKRILRYLQGTKHYGLGIKPDGANEMHVFTDADWAGDKSNRRSTTGCIVEAYGAIIHWFSKQQATVTLSTMEAEYRQRLEEQGSAVSLWCDNQSALKNMANDISSTRAKLMDIEYHFIQDEVKKGKVVVGYCATDEMPADGLTKALLIEWFTEARRMMHVVSREDSVAMKALAKSVQLDGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WNE2</accession>
    <name>A0A6G0WNE2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rap-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_013455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000172">
        <property type="protein sequence ID" value="KAF0728886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014808"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027107">
        <property type="entry name" value="Tuberin/Ral-act_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024584">
        <property type="entry name" value="Tuberin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063:SF0">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11864">
        <property type="entry name" value="DUF3384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02145">
        <property type="entry name" value="Rap_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rap-GAP" evidence="2">
        <location>
            <begin position="1078"/>
            <end position="1307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0728886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1313" mass="147500" checksum="E740C91BF3808D10" modified="2020-08-12" version="1">MNVLAKALNPSPTPLNDGEVAVLIDQLVQTRSRRQEEAETRLNSDNLSLSGLLTISRVDERGYLKQIAQVTASLKRIRLGSTQLERVWPCMAELLSQRQADVRSLGYDFIDVCTELHHDRLSPSMRMDIFDNLAHGTGDYARRQKSIRSLLQDGRYTTPFAAHLGEFFLTFLDTSDAQKEMSSLLHCILRRSPHALDPPTLNAIGKLLAERCDTAIKNADKETCKRFLKFMTILVTHKLDVAPECLRTLCRLVNNDGVNAWTIMKHLLLGASGYRILRCLMEILEEENASPLVLRGAVFFIGMSSWGSQRIPSLEVGWASILSSLLPVLECGHDVVIFEVVLSVQRLIKKYGEQIHVEWDLIFEFFKRLFSWMTHRAVGFDSGRGVDNTIDGAKNINTPGQLPSEILDTLLLIDDLYKPKDPNQHQHQNRFQGDPFDFFAVVELYMDFCPLDTIVRLLEFREAACYPDIHSNWLRSLKDFMSTFFSSTTVQVTIRLKALTMLKEIVKSCRHIYEDLLLEEVFLPTFQHIYTDEDVQVRKEALDFVAAVAGTIETVKFPAIVDILHNAVVHSIYHDTQHQAVAWIGNLLSSCFEHMPASRCVRLFDLLTGYCVTHRDVDVRRIAISSLMQVCTANASFQMQFDHGEHRTNSPFLVAARLSMKSFTATLPIPKLVIALLTILSTETHSINFELAVEMLFRMVSNRFVLHDVDLTDMMLKLVSCVEFRAFGRAATIDAAARLRSKRSRAVTDSPAPDEHHGDVWANVIATRYLRMGLDLLLLLASHLGTPSGSVILRALQTFVTSLDFQPNPLKRSIDRHPSDLSSSNIFRPDVEALHTEEITLVHTLVGGLNMFALWIPEHVNPVLSTIFRSTIHRLCKPPPDDHDCQVEITCLGLILVWNLLVSVPDVQEEDLALITEFSRHFLLSKTPTKYSTVLAMHVLMKCFSLSSASLRLQLAHETLPYLQGTPKKSLLVETAIDFIQTRVYAPSDTCHQAKPSSPYAMSWLHQNTIVTLNSDSICTEITIRRATISCTLKLPTASVPIEPLHIMTLLYNVDPLMTTTYGGLQRLTDGEALHRALNVLDRSPSYETHKVGVLYVPHGRASESELLDVVGGSLRYAQFLRDLGTLITLKDFDGYNAGLDVSESESDGKHGLLYKDSVVMFHVATLMHHALADLTDGGDSDSTAVVDRRRGKKRHIGNDFVHIVYLDYDGNPQDAVPTLTSHFNDVHILVQPLDDDGTLYRTQVKCKSPLPPFGPLHGIQLVPGNVVAAAARLTAIHANLACRVAHQDRFDFVLNAEERLKQIKQIGHRHCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WSZ4</accession>
    <name>A0A6G0WSZ4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_012028</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000153">
        <property type="protein sequence ID" value="KAF0730609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WSZ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009643"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0730609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="249" mass="27603" checksum="C20D44671DABD725" modified="2020-08-12" version="1">MTSTRSTIAMTTAVLAASVWIYFNSRFRIVMWLRYVALCLAVVAWLLLPRMDKKLVEKKTPSPATEPEHETRPSHEDNEITAIDNESSGANDRDDTEADETKEVPEFVCSGAASPSLQRRPSRDVLLTTQEEKWARDANGNMYRSQSCKRVLIKCPTSENAAVLQSMGSFAAQAIPQPSLAAASSPMSFVDYLTHLSSMYATLFLEFAIKSVGSAIFLATCGVIWNFALGINAEVSFHALVWKHLQDFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WUW4</accession>
    <name>A0A6G0WUW4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_011497</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000146">
        <property type="protein sequence ID" value="KAF0731237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WUW4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011602"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0731237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="388" mass="44901" checksum="50C778AC0940341B" modified="2020-08-12" version="1">MTQRQCMEDIDDEDLVQITGDAKLKRRIYDRKKQRRYREQLLRETTHLRNLIVDLEKQVSQLSLAKSESSDGTAVVAATDPLLSWKEVALALRDDVHHQHEMNHALQKHIAHYRELTRKMQMWVDASTAIPPPPPSLPNWRHVTLLADPAARQCGTDWITRQLYHNVDALFERVGFPNDEHGEVDDMPFDFSDPECYQCVRRLQREFPISASTLSDYLMQNLWIYCMVGAVVPSTVRQTIVGDCTYQHVIKTPFELANLISRKFVDSDRIVLVGTQILEDEAEPHDFRQRHRIFVATLDRLTPKSARIRILYMTSQSFTKAGFTPLDQEAPMWECDLSGCDSDALKLVHFQRYLQSKYDQLSHEGYLRLVQAMQASNALVDSENDVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WVF4</accession>
    <name>A0A6G0WVF4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DJ-1/PfpI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_011351</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000143">
        <property type="protein sequence ID" value="KAF0731450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WVF4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005360"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03139">
        <property type="entry name" value="GATase1_PfpI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052158">
        <property type="entry name" value="INH-QAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130">
        <property type="entry name" value="ARAC-FAMILY TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130:SF15">
        <property type="entry name" value="THIJ_PFPI FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026195303" description="DJ-1/PfpI domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="DJ-1/PfpI" evidence="2">
        <location>
            <begin position="31"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0731450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="232" mass="25073" checksum="7B1A05DC3CB18DDF" modified="2020-08-12" version="1">MKAFLLCFAIFFTALADTITAPANLTSLNIGVLIFNKTENLDSIGPTSYLELVKGVANVSVTFEIVGLKVGRIQASNLQPLYVTTSFKKAKTKWDIFLIPGGPGTDDVIADTALMKYVSKAVKESTFVISVCTGADVLASTGALDGRNATTNKIKFKRIAAKHPAVHWVRQARWVIDGKYWTSSGVSAGQDLGHAFVSTIFGDKVGKRISEILEHKAISDPSNDPFEYLIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WW52</accession>
    <name>A0A6G0WW52_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Vacuolar protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_011008</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta-catenin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000140">
        <property type="protein sequence ID" value="KAF0731704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002045"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071562">
        <property type="term" value="P:nucleus-vacuole junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045156">
        <property type="entry name" value="Vac8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47249">
        <property type="entry name" value="VACUOLAR PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47249:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="repeat" description="ARM" evidence="8">
        <location>
            <begin position="412"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="8">
        <location>
            <begin position="1055"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1389"/>
            <end position="1408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1432"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1499"/>
            <end position="1570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1442"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1463"/>
            <end position="1477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1507"/>
            <end position="1518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1528"/>
            <end position="1541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1549"/>
            <end position="1561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0731704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1570" mass="166834" checksum="11442617F678348C" modified="2020-08-12" version="1">MNLDLLWEYEKRRVVHGATAKKQHSILLDAKCIPDVALTDDKIFEKSGFALDYESHMSKRLNPSTAAPPTPPTHTATLNPTPSAQTIVLRTSDTIMSSPQRALHDLTTPKKKPLKVHDRLSLNSLLKTTHHHSNRHVTTDASPNHVNAPEERALKEYVGDFFSTRGEYVDGILYMSRMKKSASTSSLPPTQALDGTKLKETLASVDSDADADPASTPAATTQAQRCAATLANWSANPANARLMVNEGVVQAAILLSRSDDLTTRVHCGTIFMNLSAVADLRHGIIHLGAVKTLVTLLSSDDKALQATCALALCNLCCVSGDEATVVGNGAVSALASLMSDTPAVASISERALFNLTCVTEPYAQIDAVVKTFISIASSGQATTRDQTLQLCATAFANLSNLKRLRSRLMEEGIVSALAALLRSPSAHDQVKHLTVYVLCNLASTRSCRIELVTKGTVSLLVALSSSTLSVQTRAIIGNILCHLSKESSIRVRLVVEGLLSIVTAITTIHGIDENDQTSDEHICVVCATAIHHCSSTDEAQPKLVERDAIAVLMALGSASPHVQRISTLALCNLLMVKQAAVEIVGCGAVKSLVTLATQTQEAAPNSQLLYATALYNLCQNAISRDAIGAGGGVAAVSALCLGNLNASATSISILTLGAAALCYLAADANTRPYVATAPVVECVAAILRATDASVAISHPIQRFSVACLSMLSQDEPCAVLVLTRGAINAVLSTCATSRDMETKACCCDLLASLSFHAACRRDLISMPGFMASLTSLAKLRDANIQRRCATAIGNLSTERSVHDVLVTANIVTVLAVLSNSYSEESQSDCARALCNLSCSTGHEVELVNQGAVGVLFMICAVRAGSTVTKDMCARAIGNLLTLATLEKMLDEGLVKLLPAITKADTTSPIPATIFAKLLRHDSARAALCAEPPALRALFHYMQHADAASSTDSLFSSIAYDLVVHANTRTKAVADGLLAAMADLATRQKNDRLAAALLLIASAEDTRLALIAQGGISAILAIAMTVKSEPPLWMAVAALAHLSWHADSRANLDDVKISEMLVALLHRPCESMRLLDAALLSLANLSFRPDHANAMVNSGICAELLDVQQDAQGNQALLIGIILRQISHVEAFAAQALNRDTRPSIVALFCGLCDDATDNPAMTLDGSDVLCHLAFMEGLAPKLIDEFVVTAIRTLLRSSSSETLRRCAAGLCALSAAVDVRKALVDLGGTALLVHLAHTRGDVETLHCCSVALCNLSSDPRNARRMVADNAVSALLHLSTIQDNDLNRDACSLALANLSHEAPTVASGSVAALIHMSMEGKPPSSTVATHLPQPPPITTQHHEAVVFPPEFSYPVEDYTAVFAKKYNADIGDRQPPVPHLPSITVDPDTIHASMDNPSGGSTDTAEELPPGARVQFSKLEPGVDAIMLTRVQSSSSMDDMAEDHDGPSLDDHSELQPLMEDDESHERHATKGLDDKRSAKGFLKKRSSAAIQMPAASYRIKSSDTKTLHKAPSMRKRPSKAIVDALPRPASPTTPVDPPSPPMTKARIPHHQESAPAEDLRQQARKLGLWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WWC3</accession>
    <name>A0A6G0WWC3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_010949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000139">
        <property type="protein sequence ID" value="KAF0731849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WWC3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011130"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="1">
        <location>
            <begin position="51"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0731849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="340" mass="39501" checksum="451148A9C92FAD41" modified="2020-08-12" version="1">MDGAHDDRRGQNHVVVRQLHPHDILNMAAYYHVDLAKSPFLLPIVTQAVQTPLPPNWAEGKDEVSNGAIYINEITQETQKEHPADSYFVSLIQATRDKQHSTDSSPSSDSAWMEFYEDDHPYYYNFITNKRQDTMPSCGFIFTPGEHDTMLKDVFSQAAELHRLPKINSLEKLDILCFHSSWNETRLNVLEKRHADIYFSIRAKHFQFVLGNCDNVYTISHINGRDEKPLEAWDLYVGAKITILGRSTTLMKASMLTLQWLDFQTKKLMAIKEKLHNELKKYDLHHVQAKYKGKIESPEIRLSLNGVSLRQLENEIEHLRERLSTYRPDLARKIVYSLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WXA7</accession>
    <name>A0A6G0WXA7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_010767</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000137">
        <property type="protein sequence ID" value="KAF0732115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WXA7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001422"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45153">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45153:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="17"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="364"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="439"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0732115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="577" mass="65884" checksum="FCADAA9095F8FEEB" modified="2020-08-12" version="1">MMMESKPENRTLFQENSTCKKAEGDTWFRQGNYEKAIICYNKACFVNPDDYLIYSARGNAYAKLCDLKSAIANYKKLLSLMSTPPQSIKEEIAEVFNAQGYSYLVDKEYTTAILYLTDAVALDALQANYWLHRCLAYIGLENWTKALKDIDHAICIDANDADVLVLRAKLNWKLKLIDKGNSDIARAFRLNPSHPEVLDFEKKMWYQAQHLHDVACRHIINRQFEKSLDCLNSCIEFNAEDVKVLVLRASVYRELGKYDEAMADIERASRAYFDKQQPNSEDSRNEQDELGSHGLDAHSSLLSSTSHAIDEHPEITHQRNLILNDVAVSEIKNGRFEAALNAMNLAIDAEVTMASRLAGRVIDYRFYVNRGDCYRALSKSQAALVDYNCALELQPMDAEIHTRIAMIRYHFGLELFNRGAFDKAEIEFTLAIRHNPKIYHYYIRRGDCYRYLEQNDRAFNDYKQAHTLCPNDAEVMAKIRQYNPNIQGRKIQANPAPQPNQQLVLSDVRARRYQSDLFKKAEVARQSAAKSHSACMKLLLAPPKLTSPTKQRFPIAFSESIAVQRGIQVGVISIEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WXW7</accession>
    <name>A0A6G0WXW7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome b-c1 complex subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_010631</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the UQCRH/QCR6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000135">
        <property type="protein sequence ID" value="KAF0732346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WXW7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001141"/>
    <dbReference type="OrthoDB" id="405848at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.20:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.20">
        <property type="entry name" value="Ubiquinol-cytochrome C reductase hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003422">
        <property type="entry name" value="Cyt_b-c1_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023184">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036811">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15336:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15336">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 7.8 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02320">
        <property type="entry name" value="UCR_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000019">
        <property type="entry name" value="Bc1_11K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81531">
        <property type="entry name" value="Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ubiquinol-cytochrome C reductase hinge" evidence="12">
        <location>
            <begin position="8"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="17"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0732346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="67" mass="7605" checksum="36C3AD9000E3CA8E" modified="2020-08-12" version="1">MAGEDPVDVMPEIRKACEPKCVESFKEYRACVDRITAKGEGACDGQYFDYLKCIDKCSVPQLFKHLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WZJ0</accession>
    <name>A0A6G0WZJ0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_009850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000126">
        <property type="protein sequence ID" value="KAF0733023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WZJ0"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0733023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="176" mass="20077" checksum="7ABBD34DA93C72E8" modified="2020-08-12" version="1">MDIAVSNSWLSFWMLWILYLDIEVNLMSRPYPRLLVITPVCCMLLFTAGHALTLFNYPRIAFMICVLCGLAIPLTIHTIVHASFRLHIMECCCNTLWSASPLVNASACIVEMTDCSFSIFSAALHLLGLFMCLHGVTRSWIHHIETAVAHYSIRQAYAKYLDRLRYLSVARTEETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WZN0</accession>
    <name>A0A6G0WZN0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_009853</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000126">
        <property type="protein sequence ID" value="KAF0733027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WZN0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001762"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486:SF5">
        <property type="entry name" value="ADENOSINE 5'-MONOPHOSPHORAMIDASE HINT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486">
        <property type="entry name" value="APRATAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11969">
        <property type="entry name" value="DcpS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="6">
        <location>
            <begin position="2"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="4 5">
        <location>
            <begin position="99"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="3">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0733027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="141" mass="16298" checksum="367CA73954B9EED0" modified="2020-08-12" version="1">MEDCVFCDPLAPSSILYEDEVVMAFRDIHPRAAIHVLVIPKQHIKNTSELTRSHVALVEYMLRIGKNVLAQQCEVLLVESTSETHIFGFHQAPFNSVNHLHLHCIVPPFAHWWDRFRYSETSWISHFISAKSMIDQLVIYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X0K1</accession>
    <name>A0A6G0X0K1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="10">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_009613</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the E3 ubiquitin-protein ligase UBR1-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="10"/>
    <dbReference type="EMBL" id="VJMJ01000122">
        <property type="protein sequence ID" value="KAF0733364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009105"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071596">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the N-end rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd19673">
        <property type="entry name" value="UBR-box_UBR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.30:FF:000002">
        <property type="entry name" value="Putative e3 ubiquitin-protein ligase ubr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044046">
        <property type="entry name" value="E3_ligase_UBR-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039164">
        <property type="entry name" value="UBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055194">
        <property type="entry name" value="UBR1-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497:SF24">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497">
        <property type="entry name" value="UBIQUITIN LIGASE E3 ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18995">
        <property type="entry name" value="PRT6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22960">
        <property type="entry name" value="WHD_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="12">
        <location>
            <begin position="88"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="9">
        <location>
            <begin position="88"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1035"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1044"/>
            <end position="1055"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0733364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1716" mass="194549" checksum="DF98611E5281592D" modified="2020-08-12" version="1">MAQWTTPMGLGVYVEQELKKGSTDDQILPEGWMLQLLEDGHLPEDLKLFVEAILAAPIRILGDSRYQRVDQFLRDLHAQHDRLTPKSGVCGYMFKNNDIAWNCRTCQADDTCVLCQTCFQNSNHEGHEVFFHRTAPGGMCDCGDVEAWKPEGFCKDHTGSGDSDHKMELPAPFDRIIRCVIAEFVRFITFVAQHSVDSFDDFKVAEIGEAKKRHHLVKHPGEPNPKIFHTRISNDDVHTDEDLVNCLVAKNFPLQFAEEFTHSVDGHGSGMLKENQTLADALGWMRQMKEATWFASVIDNDHIKYEKAWNDVFNYLVSIFAVSTSVQSILFDQLFRKTSSAVYKFDRIPLALLLQSTPHLKKELVKGMKQLYLAIMGSKEIKMQFAPLYARLYSRLMMQYFCGIGTERENIFGLGVQIFTTPSIVYQLETEFGLWDTVLTTLQEAMSLAVVRIENDSRSVYNAAHMAIKYRRYYPLLQDVNHLLMIPNMSVKFAESYASCFMDVLKDTSHINLQSRVPEHLPHVEREDNSAWIASFTLCMHLDGYVLPNMYKSLRSQQFDESVLWILFDAYYKALNDFSTAAGLTYSPKGLVAYSVASMPVSFHYPLHQAWGRFVLEMLHRDLFIPVKSRMAQESALIDALLEFPLRSFVLSSQVASNMWVRNGKDMMVRQVTSYYSLSSNLSFRDLDLTTIQFCLLLLGPTKFVSVFFYRYDIVPYLSKGDSWLNKVSMEKRALYVAECLLKLLWIALELPPAPNQSITEYLRRDVLHMIMVKPHVFSHLREQTNPIYCNPGFELINDDTKNRELINLLQEIADLQTSSNQDMAPSKFALKSQFYKEYDPSYFHVSPVNHVEAQVARQDVVFKQWTPEKELIPTVYQMPNGHPEFLECRKVLVEAEVFDFIRACLNDGLIQGDENVLSRILHILTVQLYMAEMDSSLTPFIRDHICKGPTESDGDKDGSKRQKVDSAGYVRLTAIHDQSILVHLTKRVQQYKSQAETSHKPQWSAILFVLKAYMAFDPTVASFLEEEVFPKKEETSNAPLDAAARRELQKKRQQEAMAKMMKQQSSFAAQLEDEDDEMDMDEDDNAPSCPECIICALVKKDDPVMYVGLLQKTPFRFKSTGVEPKERGDTMHVQLCGHAVHLSCIEQYTATMRREIQLGMAQSTIAFDPAAGEFLCPLCKALCSTCLPHVTFPASAAAKMEHFFQRALDPDALTEWLTQTLPSHIRARSSEPQDANAQPDAIQSFAESFFPPSVRGTDELLEKPKELSQLLLRTVANVFHMSQLQGLSAAMCHLVLNSTDPIPLAARFGRQFSSDAEALIDPFGPRDDTKLHAIFMVLTQLRHIFATADDYWHYLPLAVEANFADADPSLFFMGLSLFEHDLFSVLLVICSCLKEKSDMLWTIRLFCALHMTQVLLQTMQPLPPHRMETGEVDNATPYALLRDQFAQAAGLSVSADAPSGAILHGLFEANCNEFLRKATLLVRAIFRGWNDPDSAMYLNFCSTLRLSTDFKQLCGQLGVPDPISLLQPGSPWATKMLQYASRAANVLPLSLLVNRDSSLWAAHISIVRFAPVYTDFYSQVASVVVCVTTGAIQEAPAICLLCGEVVCGGTECCKRRQRGACSQHVPTCGCGQGAFFLIRQCQMLLVSTAGRSCFFPSPYVDEFGEEDHNVRRGRPLFLRPSRYLALMQLVFSHSIASEVSKNRRTSEQYIRVHYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X141</accession>
    <name>A0A6G0X141_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_009728</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000122">
        <property type="protein sequence ID" value="KAF0733488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X141"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0733488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="109" mass="12326" checksum="BB4CD4C7BDB3202A" modified="2020-08-12" version="1">MPQLPKFLNRQMRWKFPIWWDKMTNSSIIPAPGAETLHGVFNCRMLSMTGATPSRTKFCFISSTTLEAITLGSEFDISETNLDRSDLRTLNSFVKAFTLEAIANVAVHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X182</accession>
    <name>A0A6G0X182_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_009564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000121">
        <property type="protein sequence ID" value="KAF0733633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X182"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009862"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0733633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="162" mass="17205" checksum="AF5B4B388E9C6CC1" modified="2020-08-12" version="1">METAPPTAELPAVKDIKPPVPFVPRPTEAVIAPPTPPVEVPVERVMAPEFPPDAEFDDKETAPEGPFDAIPLSREIAPPLTDAPAVIETEPPVPLDPVPAAAEIEPEEPPVTPLVDRVMEPDVPPTAVLVEIEIPPELPADDVPLSIETEPPDGPFPAFSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X1L1</accession>
    <name>A0A6G0X1L1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_009505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000120">
        <property type="protein sequence ID" value="KAF0733660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X1L1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019464"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0733660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="162" mass="18611" checksum="F614BDB0954BE8BF" modified="2020-08-12" version="1">MEKRGPLTPTSELSSQIALLRAQLEIATKEKNDQQAQYQRRIDFLERQVDVLKRGRGSNRRRSSSMSSDGGSGDWTMKPDFAARSACSVVSERDTIFETKRTWRDMWKNLWGKRSRDSEAMRSSIWEAKVDNGRIVFVDPEAKPSKKQGKKRRGISGESDWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X224</accession>
    <name>A0A6G0X224_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_009459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000119">
        <property type="protein sequence ID" value="KAF0733902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X224"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011830"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0733902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="135" mass="14548" checksum="4FD2C33B07BD1C1F" modified="2020-08-12" version="1">MLFVGGGDMALLKNWHTVASAISRPAALHILDTVQGDLKRFSESLLALSHSTIRHRLIFQSAISQAHIMIVAVVAIVGVVVAAFGLRVVKKHQTKQTKSRIVKLGNPDDSSMAYENIASPKATQVKPLNALEATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X2B1</accession>
    <name>A0A6G0X2B1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_009148</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000118">
        <property type="protein sequence ID" value="KAF0733971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X2B1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007008"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000027">
        <property type="entry name" value="Heat shock transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF206">
        <property type="entry name" value="HSF-TYPE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="9">
        <location>
            <begin position="28"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="159"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0733971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="215" mass="24581" checksum="C78D3460D509E626" modified="2020-08-12" version="1">MLDDDEPMSEENDDSESPAEDAKKATDKAIPFLEKTYALLDVCDKRIAAWATDGLSFFILDSTLFATRIIPRYFKHNKFSSFVRQLNFYGFKNVNSKTTKAGVSGGHMKVVFQFKHPRFIRGSPHLFRSIKRKRPCQMECKGDTSTKASSELLAQANEIQQLKQSMDNIQHVVEDLRYQISQSNQLIAQLMQERGRYLPTSTNCASQIDPRFISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X3U1</accession>
    <name>A0A6G0X3U1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb/SANT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_008694</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000109">
        <property type="protein sequence ID" value="KAF0734615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X3U1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002835"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024752">
        <property type="entry name" value="Myb/SANT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47072">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47072:SF4">
        <property type="entry name" value="MYB_SANT-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12776">
        <property type="entry name" value="Myb_DNA-bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like" evidence="2">
        <location>
            <begin position="4"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0734615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="311" mass="35003" checksum="D66C739C3B2551D9" modified="2020-08-12" version="1">MTLWTDELDSVWINEMIHQANVLGKRSNNGFKKEAWAAVLTKLNNIPGCEFNMMQLKSRNAAMREKFSVVWSMANASGMGFERTRSLVVCVSTTWEAFLQGKSDEIKKWRNKPFPLFTLCETLYSGTLAKGKHVFASNVPICHIPCHLLDSDVESSHAPLDGDIASDDGEDEPPQEIYDDKESETAQERVPQQTHRRVSLDESPPKRKRQSAATVLAAELRAQSDTMSQELALFSKAIMNSSKTDTDSAVEDAIELLQTEFEYILVEAEILSAIEVLANVLKAKIFLKLRGNLREAWLRNQCRIMSSCDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X4I6</accession>
    <name>A0A6G0X4I6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_008542</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000103">
        <property type="protein sequence ID" value="KAF0734880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X4I6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002548"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020346"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21037">
        <property type="entry name" value="MLKL_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059179">
        <property type="entry name" value="MLKL-like_MCAfunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF214">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="275"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="744"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="586"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="686"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="588"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="599"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0734880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1020" mass="115596" checksum="28F9488A6778BF9F" modified="2020-08-12" version="1">MSEYSSQSLSMTTTQEAIESIEDVVKWGVRHIPSANPAHQTILRIACSVMELCLKFRINKEDVLTIGEMVARVTRSIVFKGIPEDEVYHLDDLTTVLARIHTYLEEIFEATKGWNVLMDKTQRESMAKAIATQITLYQDDIRRTASFLDVDLDIQIVGSVDDLMQDMQAMMDKLGKMDHYISLARSDGTLNRQVDNLLEMAIQLQRGLDHYHKNVNLRNVKTSPNFEASVLASFDKVIHAVKDSWRASKIAHDLPLDEMLEEWMLASEDVVYDPNNKSTFLGQGASAMVYLGQYKGRSVAVKHFHTLKLADSTEFETMIRKEIKAWRDVSNERYILTLIGVCTKIASPIVVCEYCPDTITRYIRLHPEKLIEMVYQFALGLLSLHNAGIIHRDIKGGNVLVREDGTVAIADFGLSRSTESLLTQYSNVGRFVGTLNWMSPEQRFSPRKVTVQSDVWSFGMTVWQLVARDIPYRDYCQEEIEEAIQSENNRPGRPEELAKDYESLWDLITWCWKLNPLERPESRDIVSFLEERYGEKLNTPRKVKNMEEPATADTIESEDDAESLDVKINIEYRGKSGKMSAFSPIAKHRSDSRIKNPSDSRATLNNPSDVKLSGKSAIESNGDVKISVMSASRPSKQIPSRSYKVTKSSDVIMSASTSKPQAITMPKPSIFERISEVFFGNKKKLPKDTSFQSKEPQFKESRFQSNKPLSRGSRFPSSTMIENDKNGALSFPELEIFRISVSDLTLESAIESGSMSEMWRGKYLGERVAIKKLRSHNATPFELKAFVQNIQLMSQFDSPFIVQFVGAAWTGPEDLMCVMEWMDGGDLRGKMSATTSETFSWRAKYEIIYHIVEGLVHLHSMNVIHRDVKSRNIMLDSSKPAKLMDVSTSKDHIEVTMTFAVGTFRWMAPEVILDQAYTASADIYSFGVVLSEIDTHQVPYQDKVHPATGRRLVDPSIILQVARGTLHPTFSQQCPEWIHSMAMQCLAFDPMKRPTALELANIVRSKMMGLRVSLPETRMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X4R8</accession>
    <name>A0A6G0X4R8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_008576</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000103">
        <property type="protein sequence ID" value="KAF0734915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X4R8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021235"/>
    <dbReference type="OrthoDB" id="10259133at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09253">
        <property type="entry name" value="AP-4_Mu4_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14838">
        <property type="entry name" value="AP4_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000002">
        <property type="entry name" value="AP-2 complex subunit mu, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="6">
        <location>
            <begin position="182"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0734915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="442" mass="50374" checksum="F8467A5DEEA01833" modified="2020-08-12" version="1">MSISQFYILSSRGDSILFSDFRGDVPSTSSETFFRKVKFWDKGEAPPSFHVDGVNYLYVKKNALYFVATTRYNISPSYILELLTRLCRVFKDYCGILTEETLRKNFTLCLELLDETLDYGYAQDTSTEGLKAHVHNEAILVGEAALAKTVNKSILNRQSNIKAAVSVRKPVANAQANNKKEENELFCDILERLNVVFSPGGQMLNASVEGRIQMKSYLAGNPELRLALNEDLVIGQKSNGYGQVVLDDCNFHECVQLDEFERDRVLVFTPPDGEFTVINYRITGEFRAPFRIFPFVEETSPTKIEMVLKIRADMPDNNYGANVIIRFPVPHNTIAVSCDIGKNTAGQLAEFRENENQVRWAIKRFTGGSEMTLRAKITLSGPSTHVRREIGPVSMNFEIPMYNVSTLQVRYLRIPEHARHPNYKYKRWVRYVTQSSSYVCRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X4V5</accession>
    <name>A0A6G0X4V5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_008473</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000102">
        <property type="protein sequence ID" value="KAF0735001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X4V5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000074"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0735001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="168" mass="18499" checksum="2A9392DB2ADA965A" modified="2020-08-12" version="1">MEELQKKKEELLHAQRDKADKFHAILSGPGGLNETSRKTCKNLEAAISASKKPGYFSYFDQPEVVKAIIKNGELRKLQTAILQLHQKIEQVDVEIANHTKAGNVPGAAGTASDIQTFKQWFTTYGTPKPVTSGVLTSFSANPKVYGGTEHYSAFKTQSTTMKKGRLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X558</accession>
    <name>A0A6G0X558_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Amidophosphoribosyltransferase</fullName>
            <shortName evidence="8">ATase</shortName>
            <ecNumber evidence="3 8">2.4.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutamine phosphoribosylpyrophosphate amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_008264</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H2O</text>
            <dbReference type="Rhea" id="RHEA:14905"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="EC" id="2.4.2.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.14" evidence="3 8"/>
    <dbReference type="EMBL" id="VJMJ01000101">
        <property type="protein sequence ID" value="KAF0735049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X558"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010533"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004044">
        <property type="term" value="F:amidophosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00715">
        <property type="entry name" value="GPATase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01931">
        <property type="entry name" value="PurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005854">
        <property type="entry name" value="PurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035584">
        <property type="entry name" value="PurF_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01134">
        <property type="entry name" value="purF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11907">
        <property type="entry name" value="AMIDOPHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000485">
        <property type="entry name" value="Amd_phspho_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="11">
        <location>
            <begin position="2"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0735049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="519" mass="57740" checksum="18F5BD6E539173EE" modified="2020-08-12" version="1">MCGIIAVLLANKHEHCNQMLYDGLTVLQHRGQDAAGIMTAHKGRLHLRKDNGLVRDVFKQNHMLSLLGHMGIGHCRYPTAGSSSSCESQPFYTNSPYGIALAHNGNLTNSHELASDLKNANFRHVNTDSDSEMLLNILADELLKQNSHPLNVDQIFDAVTKLYQRCRGGYSVVCLINGHGILAFRDPCGIRPLVFGTRKSLYGTDYSIASESVAIDALSFTLARDVAAGEAIFIKPDGEFASRQCAPSAVLSPCIFEHVYFARPDSVMDGISVYQARRNMGSKLAEKVLRMKPDHAIDVIIPIPDTSRTSALEMSHRMNIPYREGFVKNRYIARTFIMPGQVARKKTVRMKLNAIKSEFEGKVVLLVDDSIVRGTTGRQIVQIARESGAKAVYFASAAPCIRHPNVYGIDMPTREELIAHNRTEEEIAAELTADWVIFQDLDDLKASCNLENPAIKSWDTSCFDGHYVTGDVDDAYFKRLHDERNDARMEMKNLGGAPIYRTFSDPATDDVIDIHNNHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X5A6</accession>
    <name>A0A6G0X5A6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_008343</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000101">
        <property type="protein sequence ID" value="KAF0735131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X5A6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005411"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0735131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="119" mass="13981" checksum="E43A072FC1A39C87" modified="2020-08-12" version="1">MMWALSNPFKKQRSTVLIYEPRSKSKRCWKRLFERKNDAAVVAAADEVVFEMYEPATSSSSSRPQSCQVVPVRIPVEFDRLKAYRVGGKCVPYTRNQVRRQRRHSVVRYDRIPEDMDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X5N3</accession>
    <name>A0A6G0X5N3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_008186</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000100">
        <property type="protein sequence ID" value="KAF0735271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X5N3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015511"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051359">
        <property type="entry name" value="CaCA_antiporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266:SF0">
        <property type="entry name" value="MITOCHONDRIAL SODIUM_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266">
        <property type="entry name" value="NA+/CA2+ K+ INDEPENDENT EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="431"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="468"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="502"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="7">
        <location>
            <begin position="38"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="7">
        <location>
            <begin position="367"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0735271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="522" mass="56454" checksum="2C92A41CD9D8794C" modified="2020-08-12" version="1">MGNCSYSLETGPLAINYLEFHYCVMAEHPWMSFTMLCMWLLLLFYLVGHTADEYFSPTLSTLCRKLAIPFDVAGVTLLAFGNGAPDIFSSLATSTSGTMETGVNALLGGVMFVTTVVVGAVLQSSPLACVKITPRPFCRDILALLITLGILAIDLPTSTSSMSSAMLLLSCYVVYVLAVVVPSWLSSKTNAQTTSDPYTHGVLFAFWHAPELFPTVRTKYSFVSVPESSPLPSAPAFHVDEAYFPAPTSSELATPLLDTSIKAEITPHATPRQVLASTSSTLHYILLDLLRNATIPMVLVSSWSRRRAFCSVLISPLFVCWIFSRGAFSLHDALICLSISMPIACIVYLSTYPKTAPTSRWICWLFYLLGFVSCVGWIYGLASEVVAVLTTLGVITTLPASVLGLTVLSWGNSIGDLSTNVAIAKGGCAEMALAGCFGGPVFNLLVGLGIPFLFLQKSNQTSIVPWDIHGIVSLISLGLSLLLTLSIGIVYKFSCPKWYGKVLYGLYVIYTAVHVAILCRWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X627</accession>
    <name>A0A6G0X627_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MalT-like TPR region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_008189</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000100">
        <property type="protein sequence ID" value="KAF0735274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X627"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015514"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10098">
        <property type="entry name" value="RAPSYN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="126"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0735274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="35042" checksum="8B57A7FB8957CBC7" modified="2020-08-12" version="1">MFHDGKPLAPPIELEPVTPTTQGSQLAEATPQIDLPQRMDAPMTMNTPARVPTMTRDARIRQTVFSASAIARRKQQQKQLQPTLSPSMTTFNLDKPKECAANTKRLKDYSMLAASSKRAGRAEQEALAYFCMGIIYDNSDDFVAAIDVYKKALHLLEGSDNVFFQSLVLSCIGVDYQLASSGIAPYTGRIVSADNAELRLALTFHQRHAALNVDDAGQFVAHTNLGLTCGSLGQFADAAKHHQEALRLAIRLASAYGQSLAVGNLGLLASRQGDVATATACMDQHLQLLQSVQDKSAEVNAWIQLGLLAFRQLDADKATRLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X6J2</accession>
    <name>A0A6G0X6J2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_007945</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nitronate monooxygenase family. NMO class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000094">
        <property type="protein sequence ID" value="KAF0735626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X6J2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009873"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42747">
        <property type="entry name" value="NITRONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42747:SF3">
        <property type="entry name" value="NITRONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0735626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="351" mass="37534" checksum="AB15F3B0B8BA89F5" modified="2020-08-12" version="1">MSFPKMTKLWQALGLRVSIIQAPMAGVSTPDLVAKVAANGALGSFSAGVLSPGEVRANLDELVRLVPDKRFNVNLFVETAPNVEDTIAQWNAYEKLLGPVRSELHLDPRPQSFPDEKYQYTLDANLALVQEYRPSVVSFCFGVLDRAVVRDLQAFAFVVGTATSVEEGIILAEAGVDAIVAQGAEAGGHRSSFLHPAKEALIGSMSLIPQLCDAVKVPIIAAGGITDHRHVQAALALGAEAVQVGSAFIATPESNASPAWKAAMGPSHSSTSSVVTRGLTGRHARMLRNDLVDLVLPQEECAASSGIQRRRMREIFAKKDGRYASLLAGQSHRLCHPETSVEDVLARLTQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X6L5</accession>
    <name>A0A6G0X6L5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_008005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000095">
        <property type="protein sequence ID" value="KAF0735525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X6L5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021198"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="784"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="440"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0735525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="813" mass="90965" checksum="5E1D09C337E9CCC2" modified="2020-08-12" version="1">MSGSNLVHIDSNSLDQALQKLALRINDIEASLPNHPAFSSLADRLSLLETSIFSSPPSSKEPSASTSFFHVVDDLRATLMKLHLDHDVHLSALQLELEKQKRAISALPTSNDDELLKQLVLAEMASRAHAIESKVDEVARTFSERLAEQAATEAEWKATFERSTMARIENIFSAIQENKELITNGSAITENRFKMQQDTINTVEDSVAYLRDRVTLIADNNTELARQLQSLEESTAASYAKLNELRDALTKHEEENHMTFQSIAHTQNKLSTNLQKQGDALDAHQSDTATKLAELHIQANDLFARSDTHTNKIDILHGQTAVLELRQSDTASIVAVHEAKIENVQTHQTKTHQLHLKLEKEVVAFQKDTRQRLDDGEKAFEGLNTEYARFRHEVMESRWAQDETNKMVAAEMKEIVRSFHALKDEINDVVADLPKFHMELSRTNANVANVRLEMRDIRAEHASAQENTTAVTNRLDDLRSISNAQFERHTQNNLHELKKILDGLQHVDHTDPVAVDKQLNGLALVVAQLELKHEHFRSHSTSMAEDIKHEVAGQLLQASRIISGLVRSQIYSKLLTDDSGSNDSSELKWNLRLNAAAGFAKRVHQFVEKLSPSEDNKFTIIARDVMERRVRICLEQTLAAKFRDSANSKQGRRLNNTATCISCDRPIFASSDSANQEEAIVAKTSPNGHPVDVKSVIPRRSGHTNVPPKVGAEVAHVNPQSTKEKFVYRGGFRLPHKTVKPEMDSSFASQTIHLGLTNLSQEPCLEKVALLGKCQTEAQIHTKLARPHTAPHSKSLPKLPVTPCLDLNDEDQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X7B1</accession>
    <name>A0A6G0X7B1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">SPX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_007884</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000093">
        <property type="protein sequence ID" value="KAF0735882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X7B1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003775"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14479">
        <property type="entry name" value="SPX-MFS_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051068">
        <property type="entry name" value="MFS_Domain-Containing_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045264">
        <property type="entry name" value="SPXM_SPX_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510">
        <property type="entry name" value="INNER MEMBRANE TRANSPORT PROTEIN YAJR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510:SF64">
        <property type="entry name" value="INNER MEMBRANE TRANSPORT PROTEIN YAJR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="430"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="489"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="533"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="561"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="588"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="9">
        <location>
            <begin position="2"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="262"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0735882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="688" mass="76294" checksum="CB2DA7168C62235A" modified="2020-08-12" version="1">MVKFGKRLATSVNPAWEGQYLEYRQLKKELKKLSHGTPSDEPSNEASGKDGHAHFQKKLDSEIEKIVLFFLTKQGEFASRLAAFRVEQHKLSPADNNAQLDTINELLNGYRDIGEELVKLLAYVELNATGLRKILKKHDKNHKGRKITANYINSRIESNVSHLQQLYHDEGISAIIATIRAALDELRRLQMQVMGLQPIQRSISEDEPILNRITIARQRLHQSTHYVQTIAAQALIFDSDLSDDEEEIMLKTFKMLKPSQISRFLNMLSTFLYMTNYYIVAPTSGEYATLLGGTAALSGIIVGMTPVASMLSAVLYSWWANRSFRNPLIFSTLCLVLGNLLYAIALSYNSITMVLVGRVLNGFGGARSINRRYIADNYSREERTGASALFVTYSALGMSAGPALAAILNYIPDDVRIFGYLVTVETSPGWLMFVIWSVYCIAILVFFQEPDRSAREKLTKSTITIEEGSVSENTPLARKVSSAPPLSSLWSNVPVVATLVIYVVLKLVLEILITSATTIVDWYFAWSSTSAGVFLAFLGLLMFPANVLVGYLSYRYVDGELILYSEVLTLVGIVGIICYTSSYSVVQYIFGAVMIYVFTNVLEGVNMSLLSKTIPKSFARGTFNSGLLATEAGTLGRALGDGAVSLAGIHGIEHVLNDTFVPMAVVTLLTIFYTIRVYPHLIHSSYDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X813</accession>
    <name>A0A6G0X813_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Retrotransposon Copia-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_007231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X813"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005851"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0736208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="14839" checksum="D716D552E70C4A57" modified="2020-08-12" version="1">MSEQQPVGLQVVPSSSHNDRVKAVGAVKWMSSKNFDGNNFHYWMKATCNHLKAARLWEVVIGTEVRPDVAHLAAQWDHLDRLAVAILMDSIRDDLLFGITGEETAAMIWAFITSKYHDVKWGTNAGFLGKLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X985</accession>
    <name>A0A6G0X985_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_007461</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X985"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000932"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13999">
        <property type="entry name" value="STKc_MAP3K-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF288">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="440"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0736444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="771" mass="85195" checksum="AF13C119A4E0E949" modified="2020-08-12" version="1">MSSAVAWVDDKYIVDSTRSSDDDCAVHIAGQSFASDSGFSFLQTFDKSKATDDHSSWTARCCRVYSPMRMITVCVIVLAACCAAVFLGFVLQNEVKSPSVPGVLEPKAWDIFVYSLPNSCRVLSILGVAIVLLSYVLTPSFRFNTMPLIIPLLLSQLGYAASRLIITVAPIISYYLNEKKGSTLPTSAPGAVLANNCHVGVGTTSYCGIPSSILSTTFNLSQIAFTVAISFRLLQSVGAPVESLCDTRKMDQKMTWWTISIALTSTIAATTITLVTAPTKPPCVYNPTICTSAETELLNTVIAPAAGLATVMFIYFRIRSKIQGLYPRRARRTFKSVATHYIIVFVVTWGISIFLYVLLTALHELPDINAQVIQVWANLTLDEQAREKNKVESMLLTFVPYDLQGFLTSVVAIWSFFRLRTRFDLGLSLKAINPASVAFDHPLDILGQGTFAVVVKATWFPARQVETCAPCCFKMRSDRGLRVAVKMFKLERSSKAHLNGIQEEAYLASKLVHPNIMATYGCYTVGTSLYLVCEYLGGGTLQDVLDTSSPLPYEQALLYALQIASGMEFLHGLAVPVVHRDLKPLNCCFDQTRSTLKLVDFGLSRLFRSETDPTATERRSFLPFLSSAGSRFSRMAVSDDPCISLLMTSRVGTVCWAAPEVLSDEDQTRYSLKVDVYSFGIICWQLITGKQPFSDIPGSVLAVEEAVLEGTRPPIPDDCPVHFAKLMRRAWHPKPDRRPSFRDIVSVLHAELELLRMYGTARRENAFDMTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X9E1</accession>
    <name>A0A6G0X9E1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_007088</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000088">
        <property type="protein sequence ID" value="KAF0736638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X9E1"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0736638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="137" mass="15660" checksum="DFE4E26656FAAD28" modified="2020-08-12" version="1">MRFRWQLVARLPMRSCNCVQTCIPACRTTCHFSLRDLDSAKARARSFVSRSSACNVWTNLTKSVMAARSSVSFISLIDLGPLRRIRRRRLIESSMSGRPFTKLACWNSSTVRSFTTALDFLKRYELSCRTKLSNLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XA46</accession>
    <name>A0A6G0XA46_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_006945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000087">
        <property type="protein sequence ID" value="KAF0736785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XA46"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006235"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF317">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="444"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="481"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="524"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0736785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="574" mass="63522" checksum="3B60060D3CCE9FA9" modified="2020-08-12" version="1">MPWRCQPQHRLTLYWSVIAPEKSRAQIEAEKWILVVPYAPGKYCLPLCTLPFRRWMLFIASFVAQFCNGSLYAWSILNPHIDSYIQGRSMDAMPTQNGTGSGSQSTSSLPPDQKAVVTFYVAAGVLGFAAALSGPFVERHGPRHSLIVALCLLFVGHVAAFLSMQYKSYVGLYIGYGVFCGAGYGIGYIAPVSALMKWYPDLRGTAGGFAVCGFGVGAVAWGDVYEPLIAAVGMNCFFLVFGSIISGILLISAFVLRTPPPNYVVSGRNVHGVKVSMPPTESEKLQGHSESTERVSVVLEEIRNGNYMNVFDYQKQELGEAEILYHNKVKSLRIRECVFSIEYLLLYLVFIGAVATGIILMSRVFSIGKGVFRQDDHKLTHLVMYLALCNFLGRLVCPLLSDAFIQIAQLNPAFGRKIIVGLLLVDQVVVLAFLKSLIQDPNAFGLFQVVVFFLTFSYGGAIGIMPSLLTDMFGVYNSGTMHGIILTAWSICAVGGGLTFQHYFFKIKDSYPMEQMREGETAAYIFNFHWLMVIACIGLALVPLVRTNPVDRFYPGYQYSVCGRPLVRITKKDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XAB1</accession>
    <name>A0A6G0XAB1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_006867</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000085">
        <property type="protein sequence ID" value="KAF0737062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001901"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000904">
        <property type="entry name" value="ABC transporter A family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000298">
        <property type="entry name" value="ATP-binding cassette sub-family A member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF36">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="494"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="527"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="559"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="625"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1091"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1288"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1341"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1383"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1416"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1448"/>
            <end position="1470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1490"/>
            <end position="1515"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="719"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1558"/>
            <end position="1791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0737062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1971" mass="216595" checksum="C53C2D3566094D1D" modified="2020-08-12" version="1">MAESTKNTLTEWKTPLLETPQSPLMPSLTTSTPSSAAPPLSKSHIQTLLWKNFLLKKKHPVKWALEMIVPVLFIILLGGLKKLTDDVNVPDGWSDTTPSVNVNTGTSHSLFETRQVSMAGYNFNFSSYFATETSMSGYLLNMAVQGFLGGKKLNELSQADQIQCARFALEGKVSTDPNSPFAVPTECRGRVVPYKIAIAPDTPFTRNYFATTVAKWYPRVELTNKSILVTPTIPSWSDSIEFYKDEAALEAYIQSDNYGTDLAHPVIQSAIVFNSFPSADQLGTATPIQVSLRLNSTLGRGGVIGDVPRTNIKATDPLQRSLDQTSYQNYATTGFLTLQTLVTRFVACLPTLNTTASVTCQNPLATTASSPDTDARLLKQIQNDAIMQSAVIFFNKQPLPTKIDLSNLPQASQDALVAPLRQAPQSYYGQRVMPFPIQGYLSSPFYTSVESFFAIVFIISYLFSISSILVAFLTEKENKSRELMKILGVQDNSIIWSWYITYGVIFIISAILQAAASASGLFPNCSIVLVFLFFLLFGWSVLAYGFLVSSIFSKSRLGTYIGIVVFFVMYLITSGFNDTSSEGAKTIVCLFAPVAMSFGVQTMAKAEANSLGITFSNIREPYANFRFSTALGFMLFDIILYTLLGLYLERVVPKDYGVPEPWYFPFRPSFWRKVFGGKKPPSRRVQDKAEAFELEAALTDMMEPVGPELRQQEETGDALQIRALRKEFRVPGGIKVSVRGMNLTMYKNQITCLLGHNGAGKTTLISMLTGMIPATSGDATINNLSLRDDLSEIRHSLGMCPQHDVLYAELSVQEHLTFYGRIKGFRGDALLAEVDAKITEVGLTEKRHVRSSDLSGGMKRKLSLAIALLGDSRVVFLDEPTSGMDPYSRRSSWEIIQNNKYNRIVVLTTHFMDEADILGDRIAIMAEGELRCVGSTLFLKNKYGAGYNFSLVKTDACDTNALVSFVESRVPTAKVLSNVGTEISFQLPLDCSHLFAPMFSELDTNLSKFGVLSYGISVTTLEEVFIKVAEVGDEHHQHTLQPRTNGADRREDKGFKIDVNTPKQSKLAMFFIHFAALFKKRWRTAKRDRKIVLFGVLLPIAFIILGISILKFSSLATNDKPMRLGLGNYSLGASTPVPIYCVSDSDAWCSTLQSTFKGGQVAILPKETYATTTPTVFNFAYTSPPIQPNDTTGICLKTGEQLWNRGYGPTPVLGQYGAYIVRGSSQTGEISYVMAVNTTAPHAAANYKALMDQTVVQIVSQNNPAATLVVTSHPLPLTAKTKTLFTTFISFATAICVVLAFCFFSASIVPYLVSEKHPSHNSKHQQLVSGVSLPAFWLANFAWDLLLFTIPCAFALLTIYLFDITPFTGNSCTTCASTPFAGVAALLILLGFALISLCYCLSYLFRDSSSSQTFTIMINMVLGVVLMTVSVVLDVLDSTKEINKSLKFIWRLSPLFNVGNGLNSLAIFTVRATFARDGYVPGLSVFDTNVLGWEVAFLAVESFVFPLIAIGIDYLSFPKIKAAVMKDPQVADEPYEVDQDVQTEETRIASGAADKDAVVMKGLRKVYKGGKVGIVNMSLALPKGECFGYLGINGAGKTSTMKILTGDVLPSKGSATLGGFDILSQQLDVRRLIGYCPQFDALIDLLTVREHLELFASIKGVPSKFIDATVKDKMEQLNLNDFENKLAGTLSGGNKRKLSVAIAMIGSPPIIFLDEPSTGMDPVSRRFMWDVIADISTRSKESTILLTTHSMEECEALCTRVGIMVGGRLRCLGSIQHLKNRFGDGLMMHVKLAAVTSDAVAAMISSQMQGETSITKATLDSVCARLGKGLRASHISSDHPTGYVLADLLERQQSLSVKDFCTWWLSEDRFDAFSSYLTSAFAVQQGSAQLLERQNDQSRFKLLSPNLMLSSVFALVEGCKRELHVEEYTVAQTTLEQIFNNFACQQTQERGVARGVIKDEPTNDHYVAAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XCZ3</accession>
    <name>A0A6G0XCZ3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_005998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0738004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XCZ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009884"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050553">
        <property type="entry name" value="Thioredoxin_ResA/DsbE_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42852">
        <property type="entry name" value="THIOL:DISULFIDE INTERCHANGE PROTEIN DSBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="4"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0738004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="180" mass="20322" checksum="49116855DAAFD493" modified="2020-08-12" version="1">MASIIVNSTAPDFAIVDLETGATYSFCDIALNGKPTVVMFYATWCNSCVPAVEEFEMWSKHNIPTPYINFVLINVDKHIGNAMKFVSEINPKTKKPRVCTEYRGDGDMPTVIHVGCEDIPEGYGVHVVPHKLVIDQNGVVVRNFDDFHWDDIAGLFKHRFEQDNKCHWTPFLFPDATPAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XD12</accession>
    <name>A0A6G0XD12_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_006016</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0738024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XD12"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009900"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17963">
        <property type="entry name" value="DEADc_DDX19_DDX25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000849">
        <property type="entry name" value="ATP-dependent RNA helicase DBP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="12">
        <location>
            <begin position="71"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="104"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="285"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="8">
        <location>
            <begin position="71"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0738024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="461" mass="51143" checksum="704B9DA5BC42DA4E" modified="2020-08-12" version="1">MATPAAEVPAVGEEEKAAAPPAPTDAFSTDEISHSLDYIMAMGQGLDADKEYTATLDIVRSNPNSHLFSAVTFEELNLPEPLLKGVYAMKFNKPSKIQTVALPMILTNPPENLIGQAQSGSGKTATFVLGMLYRAIQDKTKQVQSLCLAPTRELARQIMAVVNVMGSFCGVETFLAIPGNEVEKGETITAQIVVGTPGRVESLIKKRTLDLRNLKIFVLDEADVMIDESGMRDRSMAIKKMIKNPHCQVLLFSATYADEVREFAEKMVPNHNTIMVKKERLSLDEIKQFWIDCKSQEKKYEILSDIFGLLNVGKSVIFVQARETAKKLTAFMREKGHSVGILHGADMAKEVRDQVLDDFRLGTTKVLITTNVLARGIDVLGVSLVVNFDIPVNREGHPDPETYLHRIGRTGRFGRKGAAINFVYDNKSKMDLAFIENHYEKKIEEAPADDLEALEKLLAWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XDE8</accession>
    <name>A0A6G0XDE8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_006162</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0738186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XDE8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011751"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07440">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF192">
        <property type="entry name" value="DOUBLE HIT, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01301">
        <property type="entry name" value="RGSPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="210"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="346"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="479"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0738186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="687" mass="76888" checksum="5974B83FA5AA9B3F" modified="2020-08-12" version="1">MGVTWSKLSHKAKQDLWGSSLLSPLFVDDDLDTLSSLSVGHTILPNFPLINHKAKVALCYEGDVSVVIPKIGTVIFKIGPQKQFLGLKRMNTAGFSFSKALHRSILEHSNDDHFVVDTEEMLVSVYSSDDKLQLAKEYLVRFVVSKMNGNEVIIKSYRAVSMQVLKRSKVVSLERHHAKHDTNNKNAGVYYLLNNVLNADSLTLLRSVSFFADLSNEKLVRLADLSTISVLAPDVVIFKENDEEGSEMFIILAGSLTVSVASKVEGEPPLVLATLQAGSCFGEMALMTRVPRAATVTVQDNAMLLSIERKAFLDFLSDNQEVKKKLTHLLQERLMKKVLSSNIVPFFAAIDYARIMTLSERFFIEDRFISGDVIATPETYDLKFSIVICGSVDVVVENHTDDGASATSSSSTTLGPGSYFGRFGLLSETKSSRRRRSSVVARTKCVLFSCSKEQIEAVIGTSPVETAEMFIRWLREKCELQNVMAHPTARSFLVEFCTAEFSDENVLFLLDVERFTSLTTTTDHRDAARHIVETYIQANAPKQVNIDHRMRDAIEAHYAKSMSSSAVDLKEARDTIDMSNAMFDAAREEITRLVTKDTFPRFKRAPQFQTMLNTFGTYTHARHISLQDAYRQFKENIVLSPRNGNNGDLFFKFVKILETVNKHKNRRATMFREANGGGGGTKVAIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XDZ1</accession>
    <name>A0A6G0XDZ1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WRKY transcription factor 19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_005683</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000074">
        <property type="protein sequence ID" value="KAF0738452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XDZ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006621"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827:SF1">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0738452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="190" mass="21190" checksum="8651E2B375A99359" modified="2020-08-12" version="1">MTKCLFNECSNTAEPHSVKCKFHRSRSKCVEANCLNQAYARGRCVRHGAKKRCIVEACAQNRRFGGFCSKHAQNHRKKKCGVDGCERQPHAKGKCVRHGGGRFCKTEGCTAHARIGAFCARHADKDSQRKKANLEPITAQKLEAPDELDLAILNDLTRDIDYMTPPFNYISTSSPISEICGGFKLDLTMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XEI9</accession>
    <name>A0A6G0XEI9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_005657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000073">
        <property type="protein sequence ID" value="KAF0738545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XEI9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013254"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827:SF1">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0738545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="280" mass="31074" checksum="3F215E1C9FBF4C51" modified="2020-08-12" version="1">MASSPSSPRAYGDAAPSIVVLARACCQFNFCTNPVATPGATKCEFHKHRALCSTPDCYNQVYARGRCARHGGKRRCQNCDGVAQTNGYCVAHGGLAHKKFCMVEGCEKQAQSNKRCLKHGGGRLCKVPGCDHYVRIGGLCHTHHILSTNNHEGTELRCAYAYKPCPNDRAFKKDGTLHSLCAFHRDKVNSSQKKYNTKKRQQRTHQNSLMDDDADPTSCIMDPIPFEEVPTTPLDMIQLDTIVFDSTGWSPPDSSDHPGGGSSDFFIRKFKYPTSYDRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XFI4</accession>
    <name>A0A6G0XFI4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_005223</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000067">
        <property type="protein sequence ID" value="KAF0739040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XFI4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013375"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004798">
        <property type="entry name" value="CAX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00846">
        <property type="entry name" value="caca2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00378">
        <property type="entry name" value="cax"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF22">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0050">Antiport</keyword>
    <keyword evidence="5 9" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 9" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="274"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="311"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="341"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="90"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="277"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0739040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="428" mass="46331" checksum="32BB042DD7F68958" modified="2020-08-12" version="1">MAARTQEAQKFLRGSSQTFPNDMEATRRASEVSTVKSIEVLEEAQKPIRKTKSQCRVVIDLLLSSYLNLFLFFIPVAAWSYFGKWGDVPIFVLNFLAMMPLANLLGEATESLAEHCGDTIGGLINATFGNAVEVIIAVFALKKGEIALVQSSLLGSMLSNLLLVLGCCFIASHVGGASESSFSGRNAATNMSLLFVTSFAMLVPTYYQHADIEESARKQEVLTISRISAIFLILMYLQLLLFQLYTHRTPPTVEDATETEADVEDEDDEPPMSFWTSLAVLAVSTALVSVSSEFLVASVDGFTEKADINRSFVGIILLPIVGNAVEHVTAIKVALKNNMELALGVAVGSATQISLFVVPFCVIAGWIMGQPMTLAFPTFDAVTYVISIVIVYAIISNGTSNWLEGAMLLTLYCLIGVALLEMELGDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XFK9</accession>
    <name>A0A6G0XFK9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_005191</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000067">
        <property type="protein sequence ID" value="KAF0739003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XFK9"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0739003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="163" mass="18045" checksum="187B54929B72EE5A" modified="2020-08-12" version="1">MSYTDVSLVNLPVASQGLCTSPSQSTACQEPCVEQMIFMHGERRPNSFTSVSNENVGSASHCGQVQTRILPPESATLHCQDENFAVWQASEPSQCCVSTAQYGAYSKLRKHYNTFLSLAFPSIQGRQTPVHTKLACVIPCNVVESFHSWIGVEDQRTLTRWNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XGC4</accession>
    <name>A0A6G0XGC4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_004923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000064">
        <property type="protein sequence ID" value="KAF0739354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XGC4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010482"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF51">
        <property type="entry name" value="PHYTANOYL-COA HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0739354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="398" mass="42356" checksum="037D85B325C9CD4C" modified="2020-08-12" version="1">MAAAPSWANGSVVKLIHAASGAEITVLVEKDKTQVTFCRVEAPYEKLHVSQNDGVTSWGPGGGKFASFVVCDADAGQVTFQLAANQKRSNGENGAEGWFLGVSSSATSGIVLAQGLSLVGNAAAQPFVATELTSKAQLALSSSALHGASLTPSQIASFCREGYLILPRAVPLELVHEALRRINHDLGRPGMMVEGGVEGAAKLAGTTSNHPAILDLFRPVHAAVESLVGRTCVVPPQGAQLALRFPEVATPYEPKGTEWHTDGMRQGKWNPFTLLVGIALSATPTAHSGNLIVFPKTHHRLHAMLQDNASELLRVCVSADQVWGDGELPDMGVPVPLLLQPGDVVLAHPKLAHRGGPNFSPHIRYQVYFRIKHKDHAALQERLETDLFADLAIGDDPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XGV4</accession>
    <name>A0A6G0XGV4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_005041</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000064">
        <property type="protein sequence ID" value="KAF0739476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XGV4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014384"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000026">
        <property type="entry name" value="TBC (Tre-2/Bub2/Cdc16) domain family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="27"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="1">
        <location>
            <begin position="204"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0739476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="514" mass="58918" checksum="7530774A4D32EED1" modified="2020-08-12" version="1">MKRSLGPSRNMTARLRRQKFAQDDQDDVSLYDIEFGNGPLGIQFETDFYGNHATVKTVVEGGQASKLVKADRCIVQEGHIVVAVNGHDVSQDPFKTVMDAIKKATTPRIVRFLDPTVLPLDQLNQHATEQLLNRDHYGFAKDDSYILKYRKQIRLKKAQHNAYSVEKEWVDFIHAHGGMAGFHEAYKSNKAEVLSQLEPLLVRGIPSAFRAPVWNILADVDTYKQCYPSTYYQDLLRGDLSPSTLEDIEKDVGRTYPEHTYFQEAKGRLELANVLRAYSMHNPTIGYCQSMNFLVGILLLFLVEEESFWLLCVMMEKYLPTENYTHSMVGCQVDQVVFKRLVALQLPQLSRVFDEGGIEIELVTLQWFLCVFVCTLPLDTALRVWDYLFLHGQEVLFAVALSILKVAEDKLVAAGAMSHSELFVVVRELGFDLHEADEFMEVLVGFFRSDETSARSEDKTKPLDVLVQKFNEFSTKLRKGSIPNDLHSNRKRFTHALIQQWRDEIRPQIRIKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XH65</accession>
    <name>A0A6G0XH65_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_004776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000063">
        <property type="protein sequence ID" value="KAF0739598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XH65"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012934"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0739598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="279" mass="31227" checksum="88BCDE28C872045A" modified="2020-08-12" version="1">MTTEVFAYLVAAYLLFTNVPVLVSKLLTVVFCVMTKHDNGPSMAVWDVSLYTGYNTTAKENEIMLRNLINQIDKMSVGSTEPIQVPMAQVPFTIVQGKNKLFLQSVSKFEQDRHRSSQRHSLMVGKSFSMTNPVFDPLVSLVLLIRVDNQVHGYHTLRLLQATNANDTHQSLVDVTEVYPSLVGPVRHVMCVAFHDTGASKCGSIVLPTAVAASFVVDTQKTIKEPIALSSCEHPLISRMVYSIMDIDRLKYYCASDPTSIEDLFAFEIGSWYHKSQTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XI08</accession>
    <name>A0A6G0XI08_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_004571</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000058">
        <property type="protein sequence ID" value="KAF0739869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XI08"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011864"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051558">
        <property type="entry name" value="Metallophosphoesterase_PAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10161">
        <property type="entry name" value="TARTRATE-RESISTANT ACID PHOSPHATASE TYPE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10161:SF14">
        <property type="entry name" value="TARTRATE-RESISTANT ACID PHOSPHATASE TYPE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="5">
        <location>
            <begin position="128"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="62"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="62"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0739869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="552" mass="60140" checksum="E312B1E0E052A148" modified="2020-08-12" version="1">MHKRPDAYKESRISDTDIIIMEERLSDEAPRRRSLFRVITAGLAVLLLVGGIAAAVVLTTSKGGKNSASSSSGNKNATSSDTTKDSTSGDSSSSSSSSSSSSSSNSSSSSSSSTSSVTDPEKDTPGITFLAIGDWGSTTGRGNDGSEPGSCCILYKKGDNAGKVDTSKPRYVVDYHAQDYVAQLMGMSAASLKPTPSRIISHGDNIYWNGVGSSDINYRMDEAFEKVYSADSLKGIKWVSVAGNHDYGGSSFICGDDNDHFRECTSIDEMLKYLDLKFTLQATYRSPGGERWLMKDHYFVERVVQNGVTVDILNLDLNNAAVHGASQICCQCYGYRWKFTQAPGDTSDPCKNTARGDKVCAGGDTNMYDKCIEKIESWAQQSYDGATKDLASSNADFKIINTHYSPHFHMDPTQMKKWYDLLKANKVHAWFNGHTHGFNHDIANWNTHFFQNGAGGGIYSETSAGVTTTDQVKTQWIASGQPYGFMEISFSKNWMKVQFVSFDKSWSFKDFNSASTTKGGLGRGHCWFIPKSLDSQGVECKSSVNGVVGMPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XI36</accession>
    <name>A0A6G0XI36_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_004450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000055">
        <property type="protein sequence ID" value="KAF0740005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XI36"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015616"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="828"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="866"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="563"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="565"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0740005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="898" mass="102203" checksum="516367B94944C835" modified="2020-08-12" version="1">MDPVVEASAYIAHRWPRPLDSKVTDATMSWQGAAHVQLDHQRPLQPLDIGLTAYQPLFCEQFMETHSGIAMECAFRSKTPRTRPSSPLPRKLVRPRPQSATTKRAQEQVPDQNVDSGAMIYRSPHFKQRALQQLEAETYRLLDKTSKIAWNECSCGPAICAVRSKNHSETTRRTASRHGVDQACRRIYKFVCRQYLRRKRNRVLMELQEKHPELLEDATLRPVSAAVPRRQSQAMKCTQLDVNPPPCKPRNKTRLKSKPRQKHPRPIDKPASAETKTTQQSQRAHSGMKSSVSINDPLARVKREVARTKATSDLKLSLNQRQTEAERGEAYIRGESAMMAIDSYLRKKQRDHKRRRVVVAVRKITPVKYMTTETLTHVVLVLQRPSCVIYELRQSLATGPLAETIEVGGVSFRLSSAHRSSRALLAKFSDRDRVTSMNDPIEESSHKQSPRLGPIIGSKAVANSSSCAAIASSTPVFHRLVPIPPFNTPTSKQLSLDSPQVAREAVAPSTEEEAELLASVECQFVAATRIQQCYSRFRERKFSQGVANDLSLLDRDKFHEKPLNIPSTPSSLDGLSHAGSSPATPTRHESPKASDDHSEVEILEFIHRLFNTAKIIQRAFRRFRGILHQKNLNFAASRIQRQYRVYVNRCEIQMGLRTFLAKHRRVERLRGQKQKPRILPWRVAAYVAVASCRFRRRVHEHRLVIDQSGAVTRIQRQYRVHRWRRAFQASLRQLLLQKQEEGSVAGVLPASESEAWQPFVDEASGMTYYYNSITGESKWSLEETQPELSVSPIEVMDDEEYVIEGLDLPQLSVVGDEPAPLQPLPPLPNDPEEWSQVVDEGGYIYYLHSRTNETSWQPPESWRVTSTDESEWQTFTTPQGSLFYYNTSTGETSWHCPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XI65</accession>
    <name>A0A6G0XI65_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clathrin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_004543</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasmic vesicle membrane</location>
            <topology evidence="1 6">Peripheral membrane protein</topology>
            <orientation evidence="1 6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Coated pit</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="6">Cytoplasmic face of coated pits and vesicles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the clathrin light chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000056">
        <property type="protein sequence ID" value="KAF0739962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XI65"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014417"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000996">
        <property type="entry name" value="Clathrin_L-chain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01086">
        <property type="entry name" value="Clathrin_lg_ch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="39"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0739962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="154" mass="17249" checksum="6E15759EB284E82F" modified="2020-08-12" version="1">MDGAAFDQANPALAAFQEEYDRKIAETALEHEKVGEENRVKAQAAMEQFKAERQRLREAKLQANRTQEQATIEKLTADLTNDNPWERVVSLVELESLKSKNAKRLAAEAKARGEKAAENSVDLEEVDLSRMKQLFLQLKSEPLDSTRAAGIATH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XIA7</accession>
    <name>A0A6G0XIA7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_004322</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000054">
        <property type="protein sequence ID" value="KAF0740079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XIA7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019524"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026017942" evidence="3">
        <location>
            <begin position="19"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0740079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="282" mass="32522" checksum="4DF3FFBA0A24BD4B" modified="2020-08-12" version="1">MTPPSMIVLLTAAVLATANRLEATRDVKFVDTFQAIDSYEKQFPDVADVHEQVRRALMEGTEEIMSPMENAEKKYKELKMVRAQIELAIAHCKDEECIREEHARAVQRIRDQGKYKGGFPPADNFFHKESFPLREFPSPNEFELERPAQQTSHHHHSHHEDNDEEEEEENEEFDESDDPDFVDEFAYDRKPKQKKGTARNFPSQDEIEEHIRRQIKAHLMEVEKDKAQDSRVCIPMTGLCDFNIILAVVWTALVALVVSVLSQSKAKTAARPPVKSKKKKTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XID7</accession>
    <name>A0A6G0XID7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_004347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000054">
        <property type="protein sequence ID" value="KAF0740106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XID7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012199"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0740106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="329" mass="36654" checksum="BA28F55C9AFA301A" modified="2020-08-12" version="1">MGNSTSAGGQRTKPPAKIVSVQPKTPATSSIPTHGDRCTEEATDTSQFESIAPPMMPPQRTSPPRLRKHKTHKSSAFNVEPESHTLLGGDARPSDIQHLVEHLIRKKPVALQKLKKYVGHDCRDAIRLFHPTAKSSSDEEAVDLVRNRVSEVHLEGFARCVWGTLTTPATHPGCTIECLERINDNTIYNRITIDDVPLVMHLLSHQTRSPNRIVIVFRNIVDDGQFPLEGQPYLVLLSGWLVLDRDQQATHARTFVKFRGTQVRQSNNNVDKTSEESTWLDAIATKLFDLVETTNKTKLHGTIHDDPGTTTATRRKHSAASNGNCFESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJ24</accession>
    <name>A0A6G0XJ24_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_004406</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000054">
        <property type="protein sequence ID" value="KAF0740173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJ24"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017108"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0740173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="275" mass="31482" checksum="D146432C214F64FE" modified="2020-08-12" version="1">MTREVKRQKLLVEKAMLEKTLRLIQDEKHEDYLSRLVPIEDDRSRLIANAETMAAHLVTSADVIFAYESEEAEKEYEMSCLKLKQDMLEEIRLEMERVKEQKKAGFGSYNKAALALHQRQANMRKTRAQASKKSNNGLTSFGFNEEWARPAAKRLTTVFKPLHKVLTTSEISDDVQEIEDAEREAGMPSELPEHMCIPARFVHGKVLYKDLVLQEDDHIRVTKPPDSITYKAIVCDLTSAEIFLLKENGKYTRLLVQDLRNGSVVVEAVEDDGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJC1</accession>
    <name>A0A6G0XJC1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_004280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000053">
        <property type="protein sequence ID" value="KAF0740279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJC1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003911"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0740279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="120" mass="13107" checksum="DD5C3B92AD26BB99" modified="2020-08-12" version="1">MSREALLRDEEDDESIVLARLGAVGSITIDGWSSAYDDTYPTALKGMSTLSPQQKRLIMLDLVAPNEFHTCIDAINQCVDDYYPCIPCFGCGYLCCVASIGLSLLVPQPCTADVRLLPFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJP6</accession>
    <name>A0A6G0XJP6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_004145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000052">
        <property type="protein sequence ID" value="KAF0740409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJP6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005185"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0740409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="271" mass="29756" checksum="D7189AC59862323B" modified="2020-08-12" version="1">MKNEDQVRKKRKPRRDDEDGETSEQEDASLNEEDKKKDAPAGDESDKKELPKKDGPAVPMATMMFPMTMMMPMMMPYPQGSVGAGATDEIPKKKKRGRPSKKSLAQQSTPTLNPADQSVPMPMWPFGMPLMPVGFKFPMNPIMVAPQVKGAKDQESTASSLLTKAGTVEEQSALKEGTPISPGHLGKMVVPSTIVVDDMKKKVRSTTGKPRGRPRTRPRPGDIITRPKLMNLAPAVIYDHMNGAHLDKDAKESGAEDDDDEEPHKSGERVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJU5</accession>
    <name>A0A6G0XJU5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">nitric-oxide synthase (NADPH)</fullName>
            <ecNumber evidence="4">1.14.13.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ae201684_004175</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NOS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.39" evidence="4"/>
    <dbReference type="EMBL" id="VJMJ01000052">
        <property type="protein sequence ID" value="KAF0740440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJU5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014842"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004517">
        <property type="term" value="F:nitric-oxide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006809">
        <property type="term" value="P:nitric oxide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.340.10">
        <property type="entry name" value="Nitric Oxide Synthase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1230.10">
        <property type="entry name" value="Nitric Oxide Synthase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.440.10">
        <property type="entry name" value="Nitric Oxide Synthase,Heme Domain,Chain A domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050607">
        <property type="entry name" value="NOS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044943">
        <property type="entry name" value="NOS_dom_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044940">
        <property type="entry name" value="NOS_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044944">
        <property type="entry name" value="NOS_dom_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012144">
        <property type="entry name" value="NOS_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004030">
        <property type="entry name" value="NOS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036119">
        <property type="entry name" value="NOS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43410:SF1">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43410">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02898">
        <property type="entry name" value="NO_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000333">
        <property type="entry name" value="NOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56512">
        <property type="entry name" value="Nitric oxide (NO) synthase oxygenase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="5 14" id="KW-0349">Heme</keyword>
    <keyword evidence="13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="8 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="15">
        <location>
            <begin position="488"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="16">
        <location>
            <begin position="652"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000333-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF0740440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1031" mass="113877" checksum="5B973EC10074E294" modified="2020-08-12" version="1">MGPPPATGGTQGTSRCPFSGASAAPVSKCPFAVTLLTTSDKVEYDPTRLAAEQKTLYGVGCQENQCQAAMMDKTNQPTVDANRSPDQVWREAYEFLLEYYRDCHPDGLAGLAARAVEVQDTIMSTGTYFQTREELEYGVRLSWRNASRCIMRIQWRNISLIDARGADVNTKLSSHEIFTKCVEHLETTLQEQDGNRVINSLMTVFPQLMPGDTTSAKIWNSQLLRFAGYEQPDGSIFGDPANVDLTKVAIHLGWTPPQRRTPFDVLPLITQGNAPDAVPVMNELPQHVQVLVDIKHPEYSGIADMKLKWHAVPAISNFCLDVGGIQYPCAPFNGWYMGSEIASRNFLDIQRYNLLEPVAKAINLDTTAPRSLWQDRAAVELNAAVLYSFQEERLTIIDHHTASESFVRHHAKEMQTRGFIPADWVWIVPPVGGSTTAVFHQEMVNFIIKPTFIMPTDNIRTLLEQLPSAAAVVETPEEATLSLVTHPVYIHYGSETGMSESFASAIQSTMASNNVTAICEPLNACDLTKLKQRCSLIIVTSTFGTGGPPANAKTFVDQLTDFQGDLSHVQAYIFGLGSSAYANFNACALEIASHLKRCKANACLEASGDETKDMKRSFKAFFGDLTVAHGLTVPEHSRLEVTIESSSTPFTAPPTDYRVAQGTMLAPLMLLNTPDRKTINYRLSLPKGHSYREGDHLAILPQNAPNMVQDVLRTLSKVDALHYVKVSNEFAPAYLRGGLTFHDIIRDYVDLSAPVPFALTKLAMQYASPGSDAKIQLQFYSLSTLAHTKWLDESNTSVGEFIIEFATVVSRIPLDELLLLCPRISPRLYSISSSNKDVPARVEITVRQAQIGDRLGLCSAYLANVKSGANVRMYVSPCPAFRLDKSVPTIMIANGTGIAPFRSFWRAAPSKQPSTGWTRWINSKTSSGSPQRVLYYGCRDASELLYEKEIKTSVDHLAVAFSRSPSHPKQYVQDTLRGDASRLRALIQSGAKVYVCGSQAMASEVKETIDNLFPYLLPSLIKTGKYVEDIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XKJ0</accession>
    <name>A0A6G0XKJ0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_003939</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000047">
        <property type="protein sequence ID" value="KAF0740706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XKJ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010119"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18432">
        <property type="entry name" value="BRCT_PAXIP1_rpt6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051579">
        <property type="entry name" value="DDR_Transcriptional_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23196">
        <property type="entry name" value="PAX TRANSCRIPTION ACTIVATION DOMAIN INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23196:SF1">
        <property type="entry name" value="PAX-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="5">
        <location>
            <begin position="494"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="77"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="232"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="13"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="112"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="190"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="234"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="289"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="313"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0740706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="601" mass="66277" checksum="CF93FB9BDA9FCC23" modified="2020-08-12" version="1">MCDGGSDTDMSDSETLADTLPNTVAGTIAGVQNTPQLWKKEFDPEPVEDIASPPRPLPLCTYDEDETQIQYCSNVISQDFGSPGRRNGKSHLELGETSVDDTQEPKGRMDNDEIGDGESSNESEDLWAGGDTLLDQRPLESTEEERDLRELINRKASLRTSPIRQDENEENTQVLDENDSMDAPTSTENQPKEEVITKSEELEEKSVSLPNEDLSTAEIASTATNDKALIAPFPVVPPASPPLPVRSDPFLPETKTIDMAMDVNTSGSPSRSKVSRKRVSKRTSAAKSGASNSPPRLSKRLSSYVESLEVDQAPSSRSQKSMQLEVSSDTSSSLNSEATTLRRRASKRQASQSYQNSESIEDSQPRRSKPPLASQRFRSQVSDTADDVIRIVLTGLEPTESILRKIKAIDGAQFEQDVARGTHVIAPSQQLKRTVKMLCGISTCHHILDEKWLSVSAKQGSPASEIEFCLEDSVKEAQWQFSLHKTMYEHSRGQRRELLRGLVFFIVNHKSVLPSAAELSKIIECAGGEVDSKSPRDAQTIVLASPEALATRAVQKVLEAAAPTRLYTPELILTGILRQELDWNANQLLIDDAKPRPRRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XMY6</accession>
    <name>A0A6G0XMY6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_003023</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000034">
        <property type="protein sequence ID" value="KAF0741831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XMY6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000853"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0741831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="108" mass="12434" checksum="D046EA5B225F4BC5" modified="2020-08-12" version="1">MATSSSESVATTILMNRFVRRNHRFLITLRERRLVQRQIVAVLEARKPHACSQARARLPSLAQKLEKVLFHIALSRSEYLNPTTLLWRLAQIYHRSQHHAPSPAAISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XPL1</accession>
    <name>A0A6G0XPL1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">inositol-3-phosphate synthase</fullName>
            <ecNumber evidence="6">5.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Ae201684_002653</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10716"/>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="5.5.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the myo-inositol 1-phosphate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.5.1.4" evidence="6"/>
    <dbReference type="EMBL" id="VJMJ01000028">
        <property type="protein sequence ID" value="KAF0742379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XPL1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017507"/>
    <dbReference type="UniPathway" id="UPA00823">
        <property type="reaction ID" value="UER00787"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004512">
        <property type="term" value="F:inositol-3-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000069">
        <property type="entry name" value="Inositol-3-phosphate synthase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000204">
        <property type="entry name" value="Inositol-3-phosphate synthase 1-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000055">
        <property type="entry name" value="Putative myo-inositol-1-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002587">
        <property type="entry name" value="Myo-inos-1-P_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013021">
        <property type="entry name" value="Myo-inos-1-P_Synthase_GAPDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11510">
        <property type="entry name" value="MYO-INOSITOL-1 PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01658">
        <property type="entry name" value="Inos-1-P_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07994">
        <property type="entry name" value="NAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015578">
        <property type="entry name" value="Myoinos-ppht_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0398">Inositol biosynthesis</keyword>
    <keyword evidence="13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="14" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myo-inositol-1-phosphate synthase GAPDH-like" evidence="15">
        <location>
            <begin position="308"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF0742379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="516" mass="56758" checksum="066E1AC8D6FBA8AF" modified="2020-08-12" version="1">MSSSAFSNEPFKVNSKNVTYTATHIESNYTYQTTFFENNVATPVSEEYLFKTSTKVPKLGVMIVGLGGNNGSTLVAGVLANKLGITWTDKEGVHKPDYFGSITQSSTVRLGTNAHGAGVYVPFKNMLPMVNPNDLVIGGWDISAHNLADAMVRAQVLDYDLQRQLIPHLQNITPLPSIYYPDFIAANQSERANNVLPGTKQEHLETVRANIRDFKAKNNLDKVIVLWSANTERFSDIVEGVNDTADNILEAIKNGEDEVSPSSVFAVASILEGVSYINGSPQNTFVPGVIDLAERHNVFIGGDDFKSGQTKIKSVLVDFLVGAGIKPVSIVSYNHLGNNDGKNLSAPQQFRSKEISKSNVVDDMVDSNRILFEKDEHPDHCVVIKYVPFVGDSKRAMDEYTSKIFMNGTNTIAMHNTCEDSLLATPLILDLVIICELAERIQITKKGGETERFHSVLSILSYMLKAPLVPRGTPIVNALFAQRECIMNILRACLGLPAENYIQLENKLASSINQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XQ89</accession>
    <name>A0A6G0XQ89_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_002558</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000027">
        <property type="protein sequence ID" value="KAF0742460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XQ89"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009362"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF251">
        <property type="entry name" value="EG:BACR7C10.4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="56"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0742460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="144" mass="15546" checksum="6293EAD759EC5AF7" modified="2020-08-12" version="1">MTSLLAHLPHLEVRVHPTKGRSVHVAAKDGIQRGQSLFEEMPFGGVVLSTMTQKLCAVCYQEADPDITCDDCSQVAFCSSSCQAQLQDIHDLECCALEDLDLIAKKSSADKDLLRLLARILSTRVATPTVAAPTVFLPTAMSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XRS5</accession>
    <name>A0A6G0XRS5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_002109</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000022">
        <property type="protein sequence ID" value="KAF0743050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XRS5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015652"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050367">
        <property type="entry name" value="APC_superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42770">
        <property type="entry name" value="AMINO ACID TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42770:SF7">
        <property type="entry name" value="MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="408"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="432"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="503"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="547"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0743050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="557" mass="61490" checksum="FA72C372392E6078" modified="2020-08-12" version="1">MPTAVQPVLPRSITDTKKNINWSKVFAASFDLWATGITIVIGGQYFSWNGGLTAGTLSYGIAAVMMGFAYICMGLCEAEMASMFPFEGGAFGLARCTWGFYAGFIVGCCEALQYIIYVACAFVFFGKMVGSIWPYAASNPYIIWILAYTLSSVTLIFGGNIYRRWNLALAIISIAFVFVYVFGSMPYVDIQAFGGGSDQLIVGGFSQFMLAFPLSAWFYVGVESINRLCSDAYEPRLSVPIAQISSILTLFCTAMMVFFVAISMDPGMPEVAGALSPLNYGFNRIFNCSDDVSVWFSIPATFATGQGFVQSYSKILTCMAGSGLLPAKMYEKHKTLKTPIYAIVIGSTMSFALCFVDYYYSLDAMFFNTCMIMGSISYTSQCVGYIYLKKNFRTMERKFKSPLGTSGAVYSIAVWAINAIAIIGFQGDSQKSFIAMLLILVVCTIYYHFHAKYQQKFSEEERLSLFFAHVANHNNAKRSKHSHKRQSKKLLSFIKRVAVEKTKEKLGPSNSTTALAHPSSDGKKKRSSGTSKDPSANEGPPASRHNTKQEADYRARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XS37</accession>
    <name>A0A6G0XS37_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_002024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000020">
        <property type="protein sequence ID" value="KAF0743235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XS37"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017992"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0743235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="229" mass="25692" checksum="5CCC3E9BE227B20D" modified="2020-08-12" version="1">MISLQQEVLLDSTVVKPTGIPPHVSLYACIGESQNAIEALPDIIVDRIEEKGVAAGNITHTLLKSTIADIIRETTNLSARDEVSPASSAPIGMFVWGERFRRLPIDFVFPSVGPTTAWELWWRGNVNLNYPPFRHIDPEDLKLLAQRSQLVEWKLIMRHFEQICAESGLFLTKTPNDDELLASSRVISAYLQTICASKSNSGQRRVSQLKLMSIVRDVRAAIKKRKVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XSK8</accession>
    <name>A0A6G0XSK8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SURF1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_001858</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Probably involved in the biogenesis of the COX complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SURF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000017">
        <property type="protein sequence ID" value="KAF0743384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XSK8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000709"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06662">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002994">
        <property type="entry name" value="Surf1/Shy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045214">
        <property type="entry name" value="Surf1/Surf4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427:SF2">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02104">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50895">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0743384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="238" mass="27453" checksum="AF9FA3095BBC5D69" modified="2020-08-12" version="1">MGVWQTNRYMWKVDLIEQRKKHLDTPVQPLPNDATFGNAPEDLEFRPLELEGKFVPNTTFYLYPRSPPIDMQDTKGRVTSGGYIYQLFQRPNGTSVMVNRGWLPKADMEEHMKLPDAPSKTEKIVGLIVQGEEEKTFSPPNEPQKRHFFWLDQPKLAKAMGNTEYVPVLVDQLANEDEARPVGEPLRKMKQNYLGFYMTPWKHAMYAGIWYTLAILGTGMVFHRFRSTARRAAKSKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XTC7</accession>
    <name>A0A6G0XTC7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_001530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XTC7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008675"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="2">
        <location>
            <begin position="26"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0743887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="181" mass="20400" checksum="DB3CDB295D5FB4E9" modified="2020-08-12" version="1">MQLPSIPSAPAIHRALKQVLDRNRPELKMRKRVTSERLEMDLLEWLEDCETYGIKITYDAIKEYAAEISATYEDRVNLTFSQGWVCSLLARHKMGRKYVHGESLSVDETAYFYGKGHTSTISKKSAKGREDVKNRITLAAAVNADGTDKKTQVHRSLSRDGLAIARQKKCILTTQAAKKDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XTQ5</accession>
    <name>A0A6G0XTQ5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_001467</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XTQ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002705"/>
    <dbReference type="OrthoDB" id="371463at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14832">
        <property type="entry name" value="AP4_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000010">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="7">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0743821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="144" mass="16847" checksum="33783FC4C4280B7D" modified="2020-08-12" version="1">MIKFVLMVNKQGQTRLAQYYDFLPIAERVALEAEIIRKCLGRNENQCSFVEYRGYKVIYRRYASLFFIVGVNNDDSDNELGILEFIHALVETMDKYFESVCELDIMFNLEKAHFILDEMIMNGCIVETNKLSILKPIHLMEKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XTT1</accession>
    <name>A0A6G0XTT1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_001430</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XTT1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002670"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006564">
        <property type="entry name" value="Znf_PMZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31973:SF187">
        <property type="entry name" value="MUTATOR TRANSPOSASE MUDRA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31973">
        <property type="entry name" value="POLYPROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00575">
        <property type="entry name" value="ZnF_PMZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="6">
        <location>
            <begin position="275"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="355"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0743779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="448" mass="50295" checksum="083B49850C3F34C0" modified="2020-08-12" version="1">MPGVSQQAVLAIQKIVGVEVVPCTSQDYKGFILLLLARDGNFQPQILAFAVVPEPTTEHIYWFILFSRRGINLDSFPVVCSALYPGVVEGVRQALPSVKVRLCMRSLLERMNQEKTISKLGQAETLVWEMHHHETELGFFKTMQQLEQVNSAAATYLRSLDTSLWATYMLKDQHSIRTYKWSTTTFTAGIHENTVENCDEAPFDLIYNYLTRMMDTTFRKSQLSADLIKKESPLTPGAQDLYAEEMNESLQYTTRPSDDLLAYVWKSGTRPKANFRVHLGEGTCTCMTMNQLSVPCRHFIAAARHFGHDQLIYNHFGAIYKTETFAAAFHKSRIEIPLDSDLSKDETILPAVAEGKTASGKAKKSRSITTGDSNPRKLKKPAVTNVSSDTPDMDMGMITAMGMNIPGLTAQMIQQYPMPPHTFLQQMHLPIQNQQPQESSPPGPFSMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XTY5</accession>
    <name>A0A6G0XTY5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_001548</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XTY5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011321"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000010">
        <property type="entry name" value="Acetyl-CoA acetyltransferase (Thiolase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF107">
        <property type="entry name" value="ACETYL-COA ACETYLTRANSFERASE, CYTOSOLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="6">
        <location>
            <begin position="4"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="7">
        <location>
            <begin position="272"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="4">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0743906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="395" mass="41059" checksum="323B8D429498C293" modified="2020-08-12" version="1">MSQIFVVAAKRTPFGAFGGKLKSHSATDLAAHATKAALQSINLDPALVDTVVFGNVAQTSSDAAYVARHAQLRSGIPIEKPALTINRLCGSGFQSIINGFHEIKLGEASIAVCGGTENMSQAPLVAYGDKARFGVGLGAGLNLQDSLWSALTDSYAKCPMGITAENLAEKVGINRQECDEFALRSQTLWAKANAAGVFNDELAPIELKVKGKVEIFAADEHPRETTLEKLGKLKPVFKPENGVVTAGNASGIADGAGAVILASEAALKHAAPLARVVSYSAVGVDPKIMGIGPVPAIQQALQRANLTLDDMDLIEINEAFAGQYLSCIKELGANPEISNVNGGAIALGHPLGASGSRIIAHLTHALRRTKKRYAVGAACIGGGQGIAIILENVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XU33</accession>
    <name>A0A6G0XU33_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_001532</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XU33"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008454"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
        <property type="entry name" value="FYVE_like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="269"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="407"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="349"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="418"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0743889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="439" mass="49384" checksum="2F20352087A932FE" modified="2020-08-12" version="1">MTLQTPVPDDFFHPPPLSPDKIEELRAIGHRAKRDVLEYSKLTGGPVEWTLITSDAKTQVYTAREGNLPLFLGTTEIETTLDETRAIFTAPTTADARRVNAAYLPDVLDEVRLYTLSAPTEDRPHHFSFVSWILHRSPFQGRIVRHRDLCAVQHLEDVEIDGKKAWLEAYKSVVLPACPDFEKKHGVIRAEFVHVGIIYMETDKPGILRVYHLEHVDPHGQVSGDMIGNILMYKMSEGQYIAMNAMQNNVYAHRLSHVSYLASASYVNKNSRSKCAVCLKKFGTFTRKSNCRRCGEVVCSKVCSAKFKVMMANILVELRVCSRCIPGPNEIDYETTLSTLNKSQHDGLSVSSQSSNPSFVKGSHPLEKLSRMTEPITLSSYSSDDMYTMAGMERNMILLDLDGPSFAMERDPRDHQTSTYSESSKGSSPRRRGDMVLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XUR5</accession>
    <name>A0A6G0XUR5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_000894</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XUR5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012061"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.30">
        <property type="entry name" value="Transcription elongation factor S-II, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003618">
        <property type="entry name" value="TFIIS_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036575">
        <property type="entry name" value="TFIIS_cen_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07500">
        <property type="entry name" value="TFIIS_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46942">
        <property type="entry name" value="Elongation factor TFIIS domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51321">
        <property type="entry name" value="TFIIS_CENTRAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS central" evidence="4">
        <location>
            <begin position="171"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="764"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="764"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="322"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="691"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="738"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="350"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="384"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="394"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="478"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="711"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0744413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="811" mass="90707" checksum="57172F856E5D0A25" modified="2020-08-12" version="1">MVSLLQNLPRPTTIHLVRLQQQCGSEGQHELRAIQKLCSDLQARRHALANRVATYELSVLEDNEIKTTLDKQKLFLDFVLRKITSLKRGIDLSKERRRMDKMKMWIEGQLQSGIPRPTLTPTTVSSATYTTRPSVVIFPTRTQPSIVPPSPKAHKAPSSSKNRDLTWLYDFASLDLKWLSQKEQKVHAILMWFEKAMEQDHSARVAKLISEQIVKALLHYWIHVRNHMADATFNTQNAFLDHARQLKHNLTANAQLRADIASERITPEALMTMSKDDLAAPERMRERLELQQTAMRSVIFRPTEANILIKTRDGFKEVAVPGIHPEVPEPSLKTPATSSSAESAGDGKSQKQPENSSTSRQPTPAAEHTPAPKPPRSTSQAPSAQPPPRPRQPNPTESSHSAQSPSVSQSQQSRHQQTSSQKRPVPSAGEYMPLKRQRSHEVVAPQEAPKQNSLKRHRSDESLESAPRNLSASKHPPEQTTSQPSQQPSLSVSNLSPEEMELEQTRGFVAAIIDNRKSVIEKMANFVYSRNNILSRAAIAPTVFAKTETINTPGKGSTIRIHIGVYTVESNIKNVSSIADIKANVMTVFEESVDSLYWRVTEILKDYAARGKRPSLILAAEDIAKKFSSQIKFDSTSRSGLHICTWRVEGVLVVKQTSTDQFLAQRLGWQGFAEFLESLLAVVQAKDAKASAPKSMTRADLPPILKHSRHSSNNSPQSSGSTNRGVSCFKCSLSHPKGPCPNHPRHESARKPSQPLSTPPSRHYQSKKPCLYYWRGKCRYGENCNRSHDEKDYPADEAIVVADVLPSRYAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XUS2</accession>
    <name>A0A6G0XUS2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_001324</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000010">
        <property type="protein sequence ID" value="KAF0744184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XUS2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016877"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="431"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0744184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="499" mass="53775" checksum="BCA0E045374F7726" modified="2020-08-12" version="1">MSTQQGGSDDDGERALLLNPRNNESIGRLQLDEQNPTKISSELTALAYLSVPLTFSLLMDIAPAFINMAIVGHLNSTAIHDDVNAVALSSMYINVTAMAAILGLAKAVDLLCSHSYASTGTVSAFGIYLQSGLLGMAIALVPVVVLNIFGKQVLVFLNQDPIVSEKAGVFLQYSAIGLPFLAIFELLKKLLLVQGITVPVALMTLLANIVHLALGYGLAQDPDLGLYGPAIARSVACVCLPIFLGLFLLWQRKIWKGWDVTWSWSETTAHLREFFHFGGPDMVSLMIEYGIFELLILLSGLLQNYQVVLGANAILINLFAVINMVCLGISMATTVRLSDLLRAYKPRQAKTASTASFLLTLTVAVLSASILVLLRQWIPKILTSDSELIECTANAILAATPLTLVCATTSVVQGVLWAVDKQDIANYVNAGGYYIVGMPLAAVFAFTLDWGLQGLWLGLAIGAGLNIAVYFWFLCGLNWKQAAKGASDRAFTQHAAYQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XV52</accession>
    <name>A0A6G0XV52_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Disease resistance R13L4/SHOC-2-like LRR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_001025</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XV52"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004404"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="3">
        <location>
            <begin position="432"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0744551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="616" mass="69211" checksum="6E6E73274A543395" modified="2020-08-12" version="1">MTKEIEDPTIRSNVFPRSQLQGDGLLYVPKDENATKRPKPAPIVNIHKEYAVTHSYEKTRQTIKEIITQHKAKALSNQERYVREQEAEMYKTAFLETRLATTGVPTLNTISVVMERRRAQGESQMKGLTSDTPTQAESIQMALQRSYGSGKLDIKSLAIDELPDAISSTFILQMARFITEVNVSRNEFRELSRQFCDAFPGCHTLNASENNIKSLAPEISRWTNLSSLILDYNRLDALPDILPSTLTNLSAARNRISSLPYMYRLSDLTAVDISNNQLVTLPNAMYELKLIRSFNCSRNKLISAALLPLPSFKSRHAKFSRDKTTDDDDIDKPGLRTRDWTQTIDPFTKQPVYYNRFTCETTRVRPAVLGKESTTTLPQIPKLHLPTAITEPTVDRVQQAKEFPGGWEIIFGIPTRFINHATGETVTRIPQELDRYGSFIYMKKLNLAGNQIQELPASMGELYQLETLEIEHNQLVTLPDAIGNLKSLTVLRLGSNYLTSLPKQFSLLPKLKELDVKLNRLAQLPDDIGNMTALTHIDASSNSLISVPPSVLLLRNLIAFNLVGNPNLKVPSASSQKNGLQAVFWEIKNQIHIDAKGMPPEPIQVTNGIADECVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XVY8</accession>
    <name>A0A6G0XVY8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_001118</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XVY8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018502"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43102:SF2">
        <property type="entry name" value="GAF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43102">
        <property type="entry name" value="SLR1143 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="7">
        <location>
            <begin position="62"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="346"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="476"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="350"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0744657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="506" mass="55198" checksum="1E170C40ADFE39DD" modified="2020-08-12" version="1">MKPAGASSADGHSAQGAAMKQPKASTVTASTSTGGKDLIIVPPTQVILTQKELVSPDLWVDKQSRGKCYVCSRPFHTLLRTKHNCRKCGEVVCSKCRVAQILHMPSVPAKEYASIQICLVCNHSILGESSTDEKLHPRNASLASALSNESGTDAAETETSDGMIPCPYELDWNWVHPWPKPPALPAAVEAQQMEVLASLNILDTPREDAFDRIALAARKFTTSSCKVACVSFMDLQKQRQWFKGSCGLAQEEMPRIVSFCTHTIYLNQPVIVLDARIDERFCLNPLVTGSGQFRFYASVPITVDGVCIGTIFVLDAETRAESDVDISRLVKLSVVVSKLLVERREAKLHPSQQSTTSSRKPQQPPSAAEDKPMRSYSMAMELPPALSRHQSTDEILPSKADFPPQPPTQAPPKEPMAEPQPQPLPDKSTTVALQDPQAKVDASGNKMEAMLMNLLSQTTLTQQQIANQQGAMHAQIGQHSTQLNKLAEAVARMEAKLSEKKTSPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XWJ4</accession>
    <name>A0A6G0XWJ4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_000735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000008">
        <property type="protein sequence ID" value="KAF0744829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XWJ4"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0744829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="119" mass="13032" checksum="FD90F4AA69C79FAF" modified="2020-08-12" version="1">MPSSRCVHYRGDTRLKVDSIDRTTTPIALDQSKRCCGHAVGNQRRRGGVCVLRPSPSPAFCESKRCCGCAAGDTHRTSTTPSFLSLLCRIQRRVLGTSDQDSSPKQLGRDSFVAFSCRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XWZ5</accession>
    <name>A0A6G0XWZ5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_000673</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000003">
        <property type="protein sequence ID" value="KAF0745102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XWZ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008848"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="43"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="202"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0745102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="425" mass="47414" checksum="D05772FEAC94F8A1" modified="2020-08-12" version="1">MSGQVYVVDNMHVIAATEKLARFKIQKNLQIQIDSDVSTSECSTLTATSREDEPPTPTSCRHEDDAMGGDEEPTCEKKKRRRRTAAQIDRKYVCTYAGCKKAYGSEGSLTQHMRLKHRSLTLSHRDRVVSTFYAPNGNNIAIRPAINFVMDMSAYSPTTQPFLGNESDLPPFGLEKLRLRSNSMPSDGYNNQQMHTDTPRWLRKKTTPQSARAHKIKTTTPRQTAKGKIKRSLSSPCGTSLHTPDPSTLLPSCDPTSINVDDLKLSYLPTTIPQPQDPYPYGKELTILNSLDWDGVKEEQRNGDMTGVLQALVEQEPVIHTEESFSTPTSPPLYAEFPMDDEDTDMLSNQYDNDVYYKQPSPVTATPPPPPSTLPAPMAAINPWEQAAIDMEMATFSFDSFNRQASFFARDGNPAAVEPSATFYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XX72</accession>
    <name>A0A6G0XX72_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_000658</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000003">
        <property type="protein sequence ID" value="KAF0745086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XX72"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003120"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0745086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="238" mass="25786" checksum="FAEF1825BA719634" modified="2020-08-12" version="1">MSDEASSAAISRELPQVIRAMSKGIGPQARIKMDGPAEKAVAEKYSAIGKTRALFGGAFGAVVGLGVWRAMKSKSRFFGAFMGGSGFMVGVVYGLLSIREEFFVDILSLPDDQSEFAKQARAIIERDMPQSVILKEAYRRMGNLSANSDLLQSAWEESKKQERLEMQRLKSWDEVKTPEVEAPVFDAAPVKKPKSVFGFAAPPSPAGQADAKPAAPEVAPTTWDEIRRRNAASSAGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XXA8</accession>
    <name>A0A6G0XXA8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Adenylate kinase isoenzyme 6 homolog</fullName>
            <shortName evidence="10">AK6</shortName>
            <ecNumber evidence="10">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Dual activity adenylate kinase/ATPase</fullName>
            <shortName evidence="10">AK/ATPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_000259</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation. While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit. Its NMP activity may have a role in nuclear energy homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with small ribosomal subunit protein uS11. Not a structural component of 43S pre-ribosomes, but transiently interacts with them by binding to uS11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the adenylate kinase family. AK6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="10"/>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XXA8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001075"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000372">
        <property type="entry name" value="Adenylate kinase isoenzyme 6 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00039">
        <property type="entry name" value="Adenylate_kinase_AK6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020618">
        <property type="entry name" value="Adenyl_kinase_AK6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595:SF0">
        <property type="entry name" value="ADENYLATE KINASE ISOENZYME 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595">
        <property type="entry name" value="POS9-ACTIVATING FACTOR FAP7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13238">
        <property type="entry name" value="AAA_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 10" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="NMPbind" evidence="10">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="10">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0745226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="176" mass="20342" checksum="40419A9EDBCA5851" modified="2020-08-12" version="1">MSSRRLPNILVTGTPGTGKTTMSQLLAERTSLRYVNVGDLVKERDLHSGRDDEFDCFLLDEDKVVDEMDDMMSSEDGGVIVDFHTCDFFPERWFDLVVVLRTDNTTLFDRLTQRGYNAKKVTENVECEIMQVVLQEAQESYVAEIVQELPSVTVQDMENNIERIVTWMNHWVQQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XXE3</accession>
    <name>A0A6G0XXE3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box/LRR-repeat protein 15-like leucin rich repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_000297</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001623"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box/LRR-repeat protein 15-like leucin rich repeat" evidence="3">
        <location>
            <begin position="328"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="15"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1251"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="834"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1258"/>
            <end position="1274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0745266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1297" mass="148468" checksum="A1749AF99A383FEC" modified="2020-08-12" version="1">MGLLEEYYRDVMNYERRPQGRRQPKKLRPKQLEKLDMRPQTNAKVSRSHPKERIVTALPRARNNQEDELAGKLKVSFKLAWRDHVAKVKPGAAKSPVVTATPANLDGTSIPFFPLQLLHQPHVNISPWTLLATDDTFFKIAAHNKRKRRLEQQKPSVEWTLGLKEQIQLHATGETKSIVANGSEQLTDAGLIAIAKSIASLECLEIAQAYRVTDAGMRNLALHCSNLTCLNISGCRGIAGAGLAAVSDHCHRMTSLAMAQCSQLEEWVLVRAFYNFARLTHLNLSGCTQIVDTTIKTMALQCRQLIELDLSFCPQITDTGMVFLAQHCRALIRLNVAASKNRFNERITDITLLSLGEHCPLLEKLNVFGCTFISDVGVQWLAKGCRHLTSLDLMHCLKLTDVAMRALGNLTPKLRQLRIGHAKSVSDVGLRFLSEGCPLLEQLHLKQLYLVSDGVKRDFGLEGLQAVAQSCTALMDLDLSGCFQVVERSLKSIGATCTALTKLNLKGCKNATPTGLGFVLRGCPALAELNLTAVEQCGNAVLQELGRCTALRELILAQCERITDGGLRHLHRLSDQLVVLNISGCKQITDVGMCAFVHSFRSRAPALETLILNGCPLITEDFLNVAALHCPLVLRLNVIGCGISTRVLSSLKTSWKYTVFRSTMSEMGFFPAHRAKERRFMEESGQLCLAAMKIQTIYRLRKARQVFSRQQEEARRHRVVRHLQSRWRGRRARQRALVEKFAFNKKKRAAMMIQRCFRRYRTKRKAQHQFEDLMLKRTEELAVVVQRRYRAVRGARIAQVARKAFRRWNRKRNEAATKMQKRWRGIAGRRKFKLAKAQREAQKEEEMQSATQLQAMIRGRQARKMAAARRQAELQLEKERNLAAIRLQCMYRQRIARRKLKARLDRQLEMHRAATRMQCAWRARQGRNFLGALRMASLLISRSHMTMVFQQRWRKRQAYMNRVWEAAIRRNQNIARLKAACRLQLWWRNVLAIFAARAQMQQLLELKRRDDAMVFWAAQLVQSHFRGLQARQYFAELKQRNESRWKQVLDVDNAYGMGFGAPFYYNQMDGTIRWRMPSELLTKEPQPKCDQCELPASAVVECATCCEYFCPECLERIHAHGKRQLHVRRKMYNYYNKRIDYGDGTFPSEWPSEIDQDAARPWDFIHFVPKDGYDALVQWIAEEDRRLYLLKQSLLAPPPPLPQEDVMDDVVEDMPVAKPRAFDEDSHGNKIVFQPVGGTKNDQDILTFDIQIDVEKPKKGKRKKRPLHAKKKLLHGTNDGMQKSPPGDDQPLNEPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XY83</accession>
    <name>A0A6G0XY83_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_000483</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018129"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23011">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23011:SF28">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="114"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="246"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="837"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="958"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="1067"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1511"/>
            <end position="1554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0745469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1554" mass="175910" checksum="84AC8607B6B31FDA" modified="2020-08-12" version="1">MNRARARWQRVRCLIQCIVQFAHTKDALSPIDCVTLPFEPGTWHRHKLERFQNAYNKDPEYRTDVDLKLLMEIVQSVAIFSHASYACKLGICRNLHTQVLHDGEVVYYEGDIIDASSGVFVVLDGVVSIYKNPSFDVSLRLSYSAWHQAKYPNDEMQFGTCVKTATVGHSFGETAIHGFLFRQYTVLAQSRTKVAVLNQSDYRRILSFNDMKWDPQPCLYTIETEPTARTAVQIQNVVDFLYNMKLFRSQPREVVELVSHRLCQRTFKANDVVSRQSDPTAKMVVVVSGRLLLYMADTSEELRCRGHSEQAPIPQTPKKVVGGVAALAERVEYDAVYGWCVGELKGGECFGEQALAYHAMESATLRAAATSTAILLSQTDLDEAIAEHTQNHEAGHRKPPNELSHLMQLMQDVPATRPAGVVRTIQAALLRCDARLFFGQFTAYALEIFARESTIRVVSSGTVLLEQDHTCEHMFVILEGSVNIHRLTARRKQRRRSSLIRAELHHELEKIETKPVGQESGLPVTATTFGTEILERCGQYLGSIPVGGAFGHALALTNSHSQSSYVVSRNLSKGSVTATLLCLPARFVKPLLQARDEYLLYNPRQVLDQATKPKDQLNSTLKLSYFLSSKPTFAALPQRTLMHLLDRMTVVEIPHNRLLWDQGEKLFHGVVIVLSGSIMLVRSSRRPTTIEPIFKATDNAEHKLVLNVTRTANTVTLMNSHDQVHTCGPGDCIGSMRFGETDAEWTTIKPETAMTLTECKIAIVQWPKGYGPEADVAKQCHDILQFRETQLLQLQDRVASQPDDPIPGKEDIDAAITHLLSMLEWKNRFPVPVQAYVAELFTFETFPPNETLFKQDEESHAFYIILSGHVNVFVQRRKRHANVSKVAAARRDNVGRRLWQDSIRKTSTMDSKDEMDPMKAIQALTKDKQRPSEQSKRILRFASTYNNLQDNSLGELEARLGVGDVLGEQALFCPGTRHRCSVVTATDTSVIMLTRGQYEHLLVHGRSRSSPVVVVRNSSERAKDLWKLVIHYIVKNRSQRSHWPSVIAFARQKRIRLIMDIVKDVPAFQVIPPDVRVKICERTLFQTYDANAVVFERGKHVERFFVIVSGCVDLFHVSSQDVPLADDSDSGALKIRSLRDGDWFGEYEILTDDACRHVMAVSPDGVRLVAIHKTEFLASWPTLNKMKDRLAFLRQSDALGALEDDRLCSVWYGIRRQKFRRNDIVVPERHHKVLDAIYWIEDGECVVYQHSTLSRSVKERRSKERDVELEMQVATLSRGNILYCDEATWKRSSLVASSQVVHIFVLTYASPPNMLHRIVGKRGMSALRRIMRVENEFQQSQQETARQLATKSEPKPIESTILPLLKCAPVSRMRGNRMKLPHFLLQRHVATASMEMTVPPQSHPENDEREQIRPATHCPLSHSTRMSGSFTLSSLMQSSVAKVDSPRCFSPLETAQILRPKIQWEETENPAIRLQKALNLQIHEEARLVQALGFVPTIKQKASRDAEALRTKHGRPSLCPQDPFKLPLPNTFKPTLQAQKAPRFAGPRKLKKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XYT5</accession>
    <name>A0A6G0XYT5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helicase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_000198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000001">
        <property type="protein sequence ID" value="KAF0745750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XYT5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019194"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005114">
        <property type="entry name" value="Helicase_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37066">
        <property type="entry name" value="HELICASE-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37066:SF1">
        <property type="entry name" value="LNS2_PITP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03457">
        <property type="entry name" value="HA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase-associated" evidence="1">
        <location>
            <begin position="244"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="1">
        <location>
            <begin position="320"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0745750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="413" mass="48409" checksum="FB233B6A1B2A1584" modified="2020-08-12" version="1">MSDTNSLQAICRNFVDAVRVARQMQKDRSDFTTLSKIFTVPAEEPWPKHLQGQTLFSANIRCFYKTKKIDATIIDELDALCFVWDPQDHQRNMELLAFKTYLSLHDDLCVPSMFVVPNLDPKWPKDTWNMHLGLVAKTIRSSWKSLPDAQRKTLIDLGFIWQDVELTADSRIAACEWFKQINGHFIVPENFVVPKDDPAWPETLHNIPLGMIVAEMKRASHKIQPSEYVALKKLGMTFDNVDSVVWEEKIQALVIYNQIHGDLLVPSRYKVPVNETRWPKSMCGMGLGGIVSRLRRESNNVCQERYNQLKNMGFVWDMDEYMWTRKIKALQTYKELYGNLRIPQVFNVPMHDSKWPKETWGFKLGRAIDKLREYRATLTPERFEMLTEMGFVWRCRRKRRQKSKKTVMSPQEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W346</accession>
    <name>A0A6G0W346_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_019111</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000394">
        <property type="protein sequence ID" value="KAF0721505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W346"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007060"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0721505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="188" mass="20703" checksum="3FB962D50A02B2FE" modified="2020-08-12" version="1">MVRCNFSIPVYDGTHVLIETLPNNYPVCVARSLNIVSNGTIWVQVQNPTGEVALLTPQTPIGVVTTLPHSYQEGSPLRFDHENPGVLTQQAYPGVISAVLDKTANKTTKPDSAKQEFPINWEGSSLDPLQRETLRQLLLEFDLFVTTSKAPGRTDRIRCTINTGDATPIKSAPFRVSQKEGELMEGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W367</accession>
    <name>A0A6G0W367_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3'-5' exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_019177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000450">
        <property type="protein sequence ID" value="KAF0721332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W367"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007880"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04332">
        <property type="entry name" value="YbaK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="entry name" value="YbaK/aminoacyl-tRNA synthetase-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015003">
        <property type="entry name" value="DUF1853"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052408">
        <property type="entry name" value="Exonuclease_MUT-7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47765">
        <property type="entry name" value="3'-5' EXONUCLEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47765:SF2">
        <property type="entry name" value="EXONUCLEASE MUT-7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08907">
        <property type="entry name" value="DUF1853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="YbaK/ProRS associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="1">
        <location>
            <begin position="664"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1020"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0721332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1020" mass="113867" checksum="0239E552E487A311" modified="2020-08-12" version="1" fragment="single">MRIKVVADLEWVLMSPHLISPEFDVLPMSLSERILADSTTQKWLDELNANPEHLYVFIAERKHKHTPLTLVVNKYFMSLLEFWLRCCPTLGVDKLVAGQQLIAPKSTQTVGQLKFVFSAKFPGHTIPVAMHWEASIKFFLFCGSLDGKDDSAMKLENFVAQSLGENLAWRADEVQRKLEMCRLEGVRSWLASHFGWQDEADQESMLSYMILRGYLFYPLAQSPSTQAKHPTLASQINPNHLQGWWTLDFETDLTRTTPTHALFAILPKVYWLSTVSATRASDGQVWVPGDEGLKEPPIEAMERNRFFALCKEYFSSKDTAMPLFIAELHPVGDGSSYVEVSRGSIMNSKTWNPDPLMQTATRFKRDNLKSDSLDAFHQRKYEQRRPVDLNGVRLFKSEVKSFDDVSLDATWSPIELVEKLRELMKSKHVGYVTLKKAVEQTLKKHGSTDFIVQCLKMVLDDASTEVMDTFRLGHMLLEAYTPKSDGSSLAFDEDVISRMEAGPESWWAIRFQIKALSKLFPNRVVPKWVQTKVEDSMWQMLSSGRRWNATAVDVCVSYDVPRDEEDVQRVLQVLISSQDYVSAEAFVVAQLKLFGKERAFVGHAFIHDPSTPAKASRRIASLVEPFAAAVSLHGDSNALPHPIENVTEQRRRLLDLTCVEMTSVRVVDTEEGAGELLSFVQALSRDGRHVVGMDCEWRPANLSQADSRQVEVLQLAFSGGVVFVLDCAALSDESMERVLHSVMNAKNILLSGFSVAGDVQRLRAAYPSLECLTNCVEVRRAAVARVGNVVQTWGLAALASTYLGIEVAKDQQVSDWAYRPLSSEQVAYAAMDAHCARLLLIYFVLDLVESVEPLVKESQHIWTPWLMRERNLSSYLRESDVAAAVEELGLSGKIHSNVDDGVGGKTVAFVSYDSSTPHYFAVVVALSKTIDMELLSRAVGCTRLALASDADLLHVFGYIRGCIGPIGLRQQSRVTVVLDAGLLDEPAINCGAGGLGRVVSLNPRELLGLSSVLSIRSHVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W368</accession>
    <name>A0A6G0W368_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_019156</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000425">
        <property type="protein sequence ID" value="KAF0721392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W368"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0721392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="95" mass="10139" checksum="E2EE362FE9A82CFD" modified="2020-08-12" version="1" fragment="single">MKEDVFMQALSPSIDQNAECASSLGILRSSEVCLTFQGLLLHRTKLASFGQVVQISAICIDPPSILGDSSGRTSVWFDLVVGVRNPILAASLAVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W397</accession>
    <name>A0A6G0W397_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histone H3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_019074</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the histone H3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000385">
        <property type="protein sequence ID" value="KAF0721568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W397"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014401"/>
    <dbReference type="OrthoDB" id="4025405at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000078">
        <property type="entry name" value="Histone H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000044">
        <property type="entry name" value="Histone H3.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00322">
        <property type="entry name" value="HISTONE_H3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="10">
        <location>
            <begin position="44"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0721568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="136" mass="15527" checksum="DFCD88B7DDCF3F6A" modified="2020-08-12" version="1">MARTKQTARKSTGGKAPRKQLATKAARKSMPATGGVKKPHRYRPGTVALREIRRYQKSTDLLIRKLPFQRLVREIAQDYKTDLRFQTTAILALQEAAEAYLVSLFEDTNLCAIHAKRVTIMPKDIHLARRIRGERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W4J8</accession>
    <name>A0A6G0W4J8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_018831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000359">
        <property type="protein sequence ID" value="KAF0721895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W4J8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019303"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0721895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="305" mass="34396" checksum="67001CDF22B87686" modified="2020-08-12" version="1">MLTRQLHGSGDEIEEPPYMILLYVMALSMSAGMSFSTCFAVFKWRDVVHDAGHGSTYMVFLCLGLWLSIGLARVIVVFLNDREDTLENSTVLYLSIPFEILFNATSLWFIVVAHEIKRRALHTGASYSQCNRMTVYSSCIFGLALCMLVILMALNSSHMMVEEVEYGKPKQVKLVVYAVDIMSWVTMSIRISAVLYGGAVALWLYWKRDRVAMRKLPMALVWIAGLFCILNTPYLLIEPFYDWNIIPAERFPATPSIVKFLTYTSGAILSLVMGLSVAGFDAFFGVYQRTSLSAKTQEELFVLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W4P6</accession>
    <name>A0A6G0W4P6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_018793</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000355">
        <property type="protein sequence ID" value="KAF0721971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W4P6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018451"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.10.10:FF:000007">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="8">
        <location>
            <begin position="9"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0721971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="446" mass="50994" checksum="3959BB1A1DF08831" modified="2020-08-12" version="1">MEAEIQQYLDLGLIRPSTSPWESPVLMIRKPDGSIRFCIDYRKLNDVTIKDRYPMPRVDDLLDVLGKSKYFSTMHVASGYWNVRMEEKSIEKTAFICKFGLYEWLVMPFGLCNAVPQFERLMEDVLRDQVWKSCLVYLDDVIVFSQDFATHISRLREVLSCLLAASFKLKMSKCKWGKTSVAFLGHIVTPAGILPNPEKVKSVLKIRPLRNVAEVRAFLGLAGYFRRFIKGFAAISRPLEKLKTAEVFQWTHECDEALNILKRKLVSPPILAYPDFDKPFFILVDACPVAVGAVLMQRQDNRDRVIAYTSQALDATQQKWIHKKDGISEIECYGIVRATKKFRPYIDRRPFTIYTDHSALVWLCKTGSHSSNGKLARWAVHLQSLDFTVVHRPGSQIGCADGLSRLPTEASLEPIQTSDSYRYDGQHEEWVLQDTVFIAATSLQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W573</accession>
    <name>A0A6G0W573_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_018588</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000343">
        <property type="protein sequence ID" value="KAF0722206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W573"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017862"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0722206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="283" mass="32415" checksum="FFF44C2B3E73087E" modified="2020-08-12" version="1">MARDHSGKRLPPHIFEAASWEAMRAKMFDHCLSHMEKKATYVGEPRQWSVSEDEPSLNDFETFISIKMGRNPFKPTSNALAQKYLQDHLSRTFTVIVFKWGNHLNNAADLQQFQEQCIQVPLRDRAGAAAEAMHQLTVSKLKETWSHIFRAYEATWRLWAYAILKKPLHQHDGLIQQPPPSHMLHLFERVGQGGDERLEQLQQNLYLSGDVVQSCLNELVILKEAVCDVSRRLDNAIKTMDTKKRMIAGVLADIQPSTQAYDPLLQSAIHLIPNTVDIDHIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W5I2</accession>
    <name>A0A6G0W5I2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_018512</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000339">
        <property type="protein sequence ID" value="KAF0722295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W5I2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002057"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026281749" description="Transmembrane protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0722295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="23903" checksum="2553C9E7CBE5387D" modified="2020-08-12" version="1">MTCMLPCVVTLVAWHVVVVRAADGSETKVSPGQVVAIVFLTLLAAGCLLYGVMYYKNLKFSNNDAALETGVSLDTMRASNGPYAVQTVEMTNQNPVMTQVTVDINLLKSDSRASAMNVLSSSQVKLSEPAIVGSLPPTEITAAIQSYRSLIQQQTMSDINWMSPIETSRSILATRRETAKDEAELADWVSAVESSRTNQVFDTMRSDLDIDDSSEGGTVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W6P1</accession>
    <name>A0A6G0W6P1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_018953</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000368">
        <property type="protein sequence ID" value="KAF0721738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W6P1"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0721738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="125" mass="14578" checksum="D0AF97DBA35D4E15" modified="2020-08-12" version="1">MAKRALNMYEQYEEYRKKNLRTKNSFSEYISREMSNQANVGDDATMTCVWSAVKHAYRLLESTIEPPKDVTYDSFLLKSNLALDGGIPLRDMRRYMHHVAATGLPLCLATFDQELFPTQHRLRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W8I3</accession>
    <name>A0A6G0W8I3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_018132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000321">
        <property type="protein sequence ID" value="KAF0722828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W8I3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012788"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0722828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="302" mass="33701" checksum="308023202A12BE6A" modified="2020-08-12" version="1">MTFDLPAGIQRRTMVMSFWTCSGMMALGYPDVVCLYYGSSAVVWFFVVIFLGASYYCLFGVIIGLVTRIPSPFSHVITISGITMFYTAVLLAQLVHVPQLNEMLRHYRSAPFKLGLNISGVMRPSGAYDIANAKSALTFIFPTSGWIMFGSILLSILVSTYFQYRENGTFLLNLNWTRTNGFLSHYGKPNWITALPLSEKKLIKIGNKLYCKPSTQATLGIATIVPRNRQFNSTEGHVSDGYDDICVCLRSSSHHPVHAYLVSMAMSSKCVWYVKKNQFAPTIGSSRLDQVAFKSHRGTCTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W8Q1</accession>
    <name>A0A6G0W8Q1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_018369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000331">
        <property type="protein sequence ID" value="KAF0722531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W8Q1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013425"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2230.10">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035927">
        <property type="entry name" value="DUSP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006615">
        <property type="entry name" value="Pept_C19_DUSP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06337">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143791">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51283">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUSP" evidence="1">
        <location>
            <begin position="217"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0722531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="372" mass="41296" checksum="08CA0DD36E3BF7AC" modified="2020-08-12" version="1">MQVTWLCVGRFLTSTELGRLSMCSKELHGHVASVALILCKEAAALQFISADAKPPVSNLMWLHCIELQMIKAYLLHATALLDVSNNSSYVVISKAFVLTCRKQCVKADKLLAQGPKLFKSNLAKPKKIDSMDLLSQREIEDLSESITCAHNRLRPLAVSKSHGKRMALPLFAWKKLYAYFPAPVFGCGLPAGECHKCLADAHEEEEARNNKKTQRFVEHTTSDALVDLVMRKGLHPPALFSTDINTFYLVPFKWMKHWRAYVKSASDDPPGPILNGHLLCVRHKRPVVPTGVGLFLAGASNSLCQPIPGIKTTAYEIVTAAEWEDLTDIYCAEVGVGFAVVQGTVHWQSQPCHLCAEHVDLSTKRSNPNKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WAW3</accession>
    <name>A0A6G0WAW3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WRKY19-like zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_017652</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000307">
        <property type="protein sequence ID" value="KAF0723422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WAW3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002134"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056866">
        <property type="entry name" value="Znf_WRKY19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827:SF1">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24906">
        <property type="entry name" value="Zf_WRKY19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WRKY19-like zinc finger" evidence="2">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0723422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="168" mass="18825" checksum="7F26D6A0C766D33F" modified="2020-08-12" version="1">MQCYFNGCNFTAVPGSWKCKFHMQRNRCKVQDCHNQVYARLLCVKHGGKLKCQVDGCDVNCRVGKFCTKHSPPEALRYCSVEGCSSHAHLAGKCFRHGGGRRCAFPDCTKFARRRGFCARHTSQEPPSKDSSSREQVVPPQNAIADVQSLLAYYYQDLGNLPSAQFVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WBP4</accession>
    <name>A0A6G0WBP4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycerol-3-phosphate dehydrogenase [NAD(+)]</fullName>
            <ecNumber evidence="8">1.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_016672</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 8">
            <text>sn-glycerol 3-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.8" evidence="8"/>
    <dbReference type="EMBL" id="VJMJ01000266">
        <property type="protein sequence ID" value="KAF0724606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WBP4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010501"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141152">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000004">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000365">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017751">
        <property type="entry name" value="G3P_DH_NAD-dep_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03376">
        <property type="entry name" value="glycerol3P_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728:SF8">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE [NAD(+)]-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000114">
        <property type="entry name" value="Glycerol-3-P_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00957">
        <property type="entry name" value="NAD_G3PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0520">NAD</keyword>
    <keyword evidence="2 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal" evidence="9">
        <location>
            <begin position="34"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal" evidence="10">
        <location>
            <begin position="224"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="39"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0724606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="371" mass="40524" checksum="5EEB1CDA6AA7F967" modified="2020-08-12" version="1">MQSTQAPFERQPQSTCAEGSFHQCQLTTNREPKKVSLVGSGNWGSAISRIISTNMKAHPSLFHPTLRMWVFEENINGRNLSDIINTDHENVKYLPGYKLPSNVVAVPDLKDAVDGADVLVFCLPHQFLSTLLPKIKEQGLVHDCIGVSLIKGIDFNEKGIVLVSDIIQSGLGIDCSVLMGANVASEVAAGDFCESTLGCNSLRHGAFLQELFHTDRFHVNVVLDAHGVELCGALKNIVALGAGFSDGLGYGGNTKAAIVRLGLIEMKKFCYRFFNGIKEDTFFESCGVADLITSCFGGRHRKCGEHFVKDKGVTWETLEATVLHGQKLQGTWAAKEVHRMIAKTKAEREFPLFTAIYKIAFEGADASTCLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WC86</accession>
    <name>A0A6G0WC86_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TAFII55 protein conserved region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_016833</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000269">
        <property type="protein sequence ID" value="KAF0724540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WC86"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018865"/>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08047">
        <property type="entry name" value="TAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037817">
        <property type="entry name" value="TAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006751">
        <property type="entry name" value="TAFII55_prot_cons_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228:SF0">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID 55 KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04658">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01370">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFII55 protein conserved region" evidence="7">
        <location>
            <begin position="6"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="190"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="194"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="277"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0724540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="355" mass="39358" checksum="82EB9E05DC6DA08B" modified="2020-08-12" version="1">MSSTTLMEQYLLRVPKKVGAELRKKMQEKEVRGVDVVAGADNKHFKFHIDEKELPATLCELPCILETHKTYDDNLFYKSGEIGQILLVHDSPEEQMLYEPVTELPSGITPPTTNIVKRKYAKTRKYPAFPPTDVARVEDTLVKIIAGGVIEDVQEELVDFHEWMVDDAHPNGIVVHDEMELIEKHPEYLHLTKGPNNNSHTTSSGANAIESGANTGGSSGMQSLANSRPDTDAEEEPEERPTPRPATSATASIDDGLDADLDELDQDDDDQGEGSLEDNPAYQALQQQQAAHTKKLTDLRKEISKMVANIQSMSNPVMKNRLQQQKDALDGEMAQVQAALDSTLASIRSMEDGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WCX4</accession>
    <name>A0A6G0WCX4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_016368</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000250">
        <property type="protein sequence ID" value="KAF0725137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WCX4"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0725137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="98" mass="10735" checksum="9AF95140499B9C44" modified="2020-08-12" version="1">MDLSYHVQFSNVAHGELVETVGQQVLGLGVGAVTDIWHADRTLEATADAAINTLGLAPRFGHTLEAVALMTLELGHLLLDDRAAHDWSHLNHFDLLYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WD83</accession>
    <name>A0A6G0WD83_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP-dependent (S)-NAD(P)H-hydrate dehydratase</fullName>
            <ecNumber evidence="8">4.2.1.93</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">ATP-dependent NAD(P)HX dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_016686</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6S)-NADHX + ATP = ADP + phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19017"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.93"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>(6S)-NADPHX + ATP = ADP + phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32231"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.93"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.93" evidence="8"/>
    <dbReference type="EMBL" id="VJMJ01000266">
        <property type="protein sequence ID" value="KAF0724620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WD83"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010515"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047453">
        <property type="term" value="F:ATP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110051">
        <property type="term" value="P:metabolite repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01171">
        <property type="entry name" value="YXKO-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000023">
        <property type="entry name" value="ATP-dependent (S)-NAD(P)H-hydrate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01965">
        <property type="entry name" value="NADHX_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017953">
        <property type="entry name" value="Carbohydrate_kinase_pred_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00196">
        <property type="entry name" value="yjeF_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592:SF0">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01050">
        <property type="entry name" value="YJEF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF C-terminal" evidence="9">
        <location>
            <begin position="3"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="155"/>
            <end position="161"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="197"/>
            <end position="201"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0724620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="299" mass="31478" checksum="5A8FE1123462405B" modified="2020-08-12" version="1">MTHEDDVKAVIPPLSFEMHKGQYGKVGIVGGCVEYTGAPYYAGISALKTGVDLCHIFCAPEAATPIKCYSPELIVHPFLSLSTVEKITPVLGRLDALVVGPGLGRDPDILDAAKAIVSAAKAIQLPVVLDGDALFLLSNDISLIHGYPHAILTPNIMEYGRLCVSLGLMDKLDLTLAAAISPDLLATKLGHVTVLQKGRVDKISNGHAVVEQASQGSPRRCGGQGDVLAGSVGAFLAWHGAKLKRAPTSVPRNALTLAALGGSLLTRECARLAFQHHQRATTTPEMIASIHAAFQNLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WEK2</accession>
    <name>A0A6G0WEK2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_016580</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000261">
        <property type="protein sequence ID" value="KAF0724831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WEK2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016412"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015215">
        <property type="term" value="F:nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044712">
        <property type="entry name" value="SLC25A32-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45683">
        <property type="entry name" value="MITOCHONDRIAL NICOTINAMIDE ADENINE DINUCLEOTIDE TRANSPORTER 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="10"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="107"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="212"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0724831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="319" mass="35243" checksum="6026E7F5BE64CE61" modified="2020-08-12" version="1">MPVTMWHDIVHANANVLAGAISGAATATMSNPLDVAKTRIQVQGGIMTQAKYSGIFQSVLTIYSEEGLRGMYRGYSAALCSFPVYWSLYFPTYELVKKHLQEPLQDYPVVAQGVAATITGTAVDVATYPLWFIRTRMHTQHLHQISSANATGRDGYSTLRSTIATIYKREGPSAFFKGMTASCFGILSYGIQFPVYETLKEQVAIDPTTNKPSAIGVVVAAIVSKAIAASFAYPGDVVRTRMQDQMGASTYKHFGDAMVQIARREGIGALYAGFRVNIFRILPQCATTFYVYELVKSTIEAQEERRLPYRRFTESSMLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WEV8</accession>
    <name>A0A6G0WEV8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4203 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_016248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000247">
        <property type="protein sequence ID" value="KAF0725231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WEV8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014688"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0725231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="29499" checksum="2A382678A0D5B25F" modified="2020-08-12" version="1">MIAADSTSGDMPSISSNATYAAIGVSTLLIGVLVAWKKPQLMWPFIMAACAATAVIILAEVCSTQTLEALFCAASVILGAIVAFRGLSGSPSLSTAISALVATGFFISISYSVKAIFIPLAVVAVGFAVAVVLVLPRCGRFMIGAAAPIGLLDAIFCAITHRHVTLMAAYDNLASDVIGAVLSAAVVALGCGILALRLSDSSIYLVQMTCMTGSFLASLSISGVLLICIQSLSMSAGVWIRLIFGTVLVGCSWHHNAILLRTAGSAAPQPTLPTKETPMGTFASVQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WFB8</accession>
    <name>A0A6G0WFB8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_016168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0145 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000243">
        <property type="protein sequence ID" value="KAF0725397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WFB8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009947"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.70">
        <property type="entry name" value="Hypothetical protein apc22750. Chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035439">
        <property type="entry name" value="UPF0145_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002765">
        <property type="entry name" value="UPF0145_YbjQ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34068:SF2">
        <property type="entry name" value="UPF0145 PROTEIN SCO3412"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34068">
        <property type="entry name" value="UPF0145 PROTEIN YBJQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01906">
        <property type="entry name" value="YbjQ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117782">
        <property type="entry name" value="YbjQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0725397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="155" mass="16960" checksum="047D62C9CADA8871" modified="2020-08-12" version="1">MLRLVACRAAPRRLVRHLSTTTNETENLYVTPDEIKSSKLLISTRDCVEGREIIEEIGIVSATVVRTKNIVEDIFAALGGVFGGETRSYSVLMNETTQEAVHRLKGAAIAQGATAVVMTKFEINTTMNRFIFGLHSTVLVYGTAVVCRPVSNDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WHD2</accession>
    <name>A0A6G0WHD2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_015214</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000213">
        <property type="protein sequence ID" value="KAF0726592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WHD2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004097"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="72"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="141"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="5">
        <location>
            <begin position="359"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="444"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="454"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0726592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="475" mass="53210" checksum="E725A1270061F450" modified="2020-08-12" version="1">MMRYTPGDILIRKAHRGKLQEVIYLVKEIFVDVNYRNQNGCTPLHAAAASGQLEVVEWLLSVPDMKPAVDDSGQTALHYAAFYGHLEVVQALVEHGIPLDLKDKFGRTPHIAAALNGHLDVVKFLVEEWEHPIDINSIDEYGGTCLHWAASKGRKEVVQYLCMAGIDIHVTSYDNRTAFQLAKDKHKTRCMQFLKSWFDISQKFVHAAEDGNDEEIKRVILEVNGQYPLRFLKDKNGKNAMHWASGSGHLSTLRILAESFDIWTDVDKFGRNVLHWAALGGHKDCALWLIKHTRDPMALQRPTLTNKTPSRCAFEAGHSALASRLQAWERGNAEYAGPDDDVVDKQRQVQPSQNRDILSVSNWLKQLELGEYTEHFEKDGFDTLRGVATMDEGDLIEMNVKKGHRRGILQHIEELKNQLAAFDAQRANTGVEPEATPTLSMLLPLAKQQPTAATHLPSQPSSLPTSGSSLDSTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJC8</accession>
    <name>A0A6G0WJC8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thymidylate kinase</fullName>
            <ecNumber evidence="3">2.7.4.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_014575</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thymidylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000198">
        <property type="protein sequence ID" value="KAF0727314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJC8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003989"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:dTMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006227">
        <property type="term" value="P:dUDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01672">
        <property type="entry name" value="TMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000679">
        <property type="entry name" value="Thymidylate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018095">
        <property type="entry name" value="Thymidylate_kin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344:SF1">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01331">
        <property type="entry name" value="THYMIDYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate kinase-like" evidence="10">
        <location>
            <begin position="12"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0727314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="208" mass="23650" checksum="32CC0693BEC8AB69" modified="2020-08-12" version="1">MSSGRRGALILLEGVDRCGKSTQARLLASRLNAVLQNFPDRTTSIGSTINAYLSNACEMNDQAIHLLFSANRWELSETLRDHLSQGKHVVLDRYSYSGAAFTSAKMKPGLDVEWCMRPEIGLPKPDLVIFLDISTEDAAKRAEYGQERYEKREFQDRVRENFFRIMEHEKWHVLDATRSIDELHQQIAGLAENVIASVQDTPIQLIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJJ4</accession>
    <name>A0A6G0WJJ4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_014526</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000197">
        <property type="protein sequence ID" value="KAF0727413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJJ4"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0727413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="70" mass="8115" checksum="D2A442F6DF02621A" modified="2020-08-12" version="1">MLYEALEDIKSLQTWQQDEISQGVSKDNSKLNDLTWEDGGFMHLGTFKKDQYGHPNVMRYPKRSSSFDAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJR0</accession>
    <name>A0A6G0WJR0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_014503</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000194">
        <property type="protein sequence ID" value="KAF0727482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJR0"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0727482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="126" mass="14543" checksum="69A67531F2DBEDBF" modified="2020-08-12" version="1">MLILRQDLKARRSYRAMILMLVELEDLLMELDAFDDNELYAWTAIENERQSIENGFQKPIAIDINENFRTLGCQREELISRVEDVHFDKLAMGICLLGHLDRLVRLVDANDIGYTHTFGNGINSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJV1</accession>
    <name>A0A6G0WJV1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 5B</fullName>
            <ecNumber evidence="3">3.6.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Translation initiation factor IF-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ae201684_014366</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000193">
        <property type="protein sequence ID" value="KAF0727537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJV1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014103"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03703">
        <property type="entry name" value="aeIF5B_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16266">
        <property type="entry name" value="IF2_aeIF5B_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000013">
        <property type="entry name" value="eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000026">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10050:FF:000002">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000112">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029459">
        <property type="entry name" value="EFTU-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003078">
        <property type="entry name" value="PRK04004.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF4">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14578">
        <property type="entry name" value="GTP_EFTU_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="Initiation factor IF2/eIF5b, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="14">
        <location>
            <begin position="375"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="211"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="331"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="97"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="246"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF0727537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="967" mass="106948" checksum="23FCB6051F70FC34" modified="2020-08-12" version="1">MPPKKGKKAPTTKKAASGGDDDWGDVLNELATSTPASAPPPAAPGAVEQPVAEKTESSVDDAVAAALASMGISADSAADKKKKKDKKKKKDGDKAESAPAAAAAPTPGPKKPLSAAAKALLERQAAQKAEEERLKKIQEEEERKFREAEEARLQAIRKKEEAAERKRQAKKAKIEAQKAEGTYMTKAQKEKAKRAQAALEAMKAQGLIDIAAEGAVKPKVTYENKKKAPKKTEEVEEKQVKKEEEETKDDAPDDWDAESEKAAEEEDAPDDWDAEEWDDSALLDKIGQKVKEEEDDEVEDLIELERRQEEDRLRQAGLALAKRQAEQEAEAAKLEEEERNRSKLRQEEERKKREAAERRHQRDEAARAAASLDNLRSPICCIMGHVDTGKTKLLDNIRKTNVQNNEAGGITQQIGATFFPVEAIKQKTEELRKTMHFDFKLPGLLVIDTPGHESFTNLRSRGSSLCDIAILVVDIMHGLEPQTLESIRLLRAKRAPFVVALNKIDRCYSWKTCPDMPFLEAFKLQNEHVQREFEDRAAQIKVQFAEQKLNAELYYRNNDLGRTISLIPTSAISGEGVPDLLGMLVRLTQERMAKSLAFVDILQCTVLEVKVIEGLGTTIDTILVNGSLSEGQTIVVCTLDGPVVTTIRSLLTPHPMKEIRVKGEYMHHQTIQAAMGVKICAQGLEKAVAGTAVHVVGPDDDVNELKDAVMSDLSNIMDSVQATKRGVMVQASTLGALEALLEFLRNGCDPPIPVSCVNIGPVHKKDVMRASVQLEHQKEFATILAFDVKVQNDAAELANDLGVRIFTADIIYHLFDQFTAYMDNIRQLRREQFADVAVFPVVLKIIPTYIFNKKDPIILGVDVEEGILKVGTPIVAINNGTLVSIGRVGSIEKDNKNVEIAKKGSNVAVKIESDSNVTYGRHFDHQHKLYSHLSRASIDALKENFKDDLAKDDWRLVIKLKGVFGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WK01</accession>
    <name>A0A6G0WK01_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_014414</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000193">
        <property type="protein sequence ID" value="KAF0727587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WK01"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009752"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="10"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="757"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0727587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="845" mass="96626" checksum="E5500B57B289831D" modified="2020-08-12" version="1">MHCDALDAELVRSAKNPQLAPLEKKQRDKQRKRDQAKRRKAMEKELVEQSRRYQVQLNSAKSWHVEMNHEEELQIKRYELDRINPFEEHPASAGYIFHPDRFNSLETDSSIFSPIFYRYSYAKDSQLDAPKAAARLGRDAPHPTCFGYAMSRNDPSIISPVFLGMVFHKRAVTLLDDDAMPNFAAGEAKKSPRTRLREQEELKRIMDARFDPTLECLVCESSQLPGCPGCWVPSSTFFTRVQAANAPEMKQVMQDKALMSSMLFGNVGKGGDDGQSIRELEFLQGLLYDIYAIRLHREKVQQFVRVVIKSVPAGSVVTLRVDPKSSVKYLYDLYRCHFDGFYRKMYLLLPTSHGMFWMDETVLATTERVLAVSNGEIALEDFQIMPSWNAPTDEVIMLLSVATMHAEKTPAMLTNYIKHNFVYHGELLGIRRDAHGVPSQIVEDPLQQSMRKKADVLVESAWDNWRMSREYDQLTMRQAMKRAYDDKMHRLAEQRPEGRPRSKREIRAYAYYTFATSEPRPLLRLAKLWQCFQKFEELKLTKKGKLLDAAFSDDTAALISLHRTATVETFDALIDKSQQGAVQPVMAVRDKFGILLGTRMGVTAKEDREYAIEVEIVLPDDVHVVEAPKKTRFHGVSSSAILAAKTWKDMEWRKDATAHKLYNGGDLLVPPYYLVRWDCFVQAYVMARSHIEKAKDQLDAYNRLAKPVQTEALLKPKEIDEWNTALEALITELPPTGALTQACRRLQGKASLLPARAARHLKALKKAQEDAAKALQENDQVVMSGADRLKHEFKLREGIWSNNIRQLTPDMDLVKERLAQSLRHGAAKTKAIAQRVHDNIEVLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WK19</accession>
    <name>A0A6G0WK19_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_014418</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family. Importin beta-1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000193">
        <property type="protein sequence ID" value="KAF0727591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WK19"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009755"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000027">
        <property type="entry name" value="Importin subunit beta-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="7">
        <location>
            <begin position="21"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0727591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="851" mass="93433" checksum="F32CEAFB7EE8130F" modified="2020-08-12" version="1">MDIPNALLATTSADGNLRKQAEDALNKAVNENPGQLMVTLSQALAAEDFPSPGRQQAGLFLKNILDAKDYALQELKIQQWYSLADDVRAAIKQFSLASLKSPDAIAAHTAAQVVAKIGSIDVPQKQWPDLLRILVENVTSGTDGVKHSSLETLGYLCESLDDDSLEEAESNQILTAIVDGIRKENPDKIRLSAVIALRNSLEFVSENFGRDAERTHIMTVVCEATQCTDVQVRVRAFECIATIASLYYEYLTEYMNALCDLTFKAVQADQPEVGLQSLEFWSSICDVELEYLEEAKYGNNPEAAANYKRYVETVLSALVPMLLNTLTQQDEDQFEDDTWNLSMAGATTLTLAAQVVEDAIVQPVMQFVTSNIQSPNWRQKEAAIMAFGSILDGPAHATIQPIVENAMPVLITCMNDPHPLVRDTTAWTIGRICEIHGTVMARCLGPLMQLIVAGLDQETKVAAHMCYAIHYIFQSFSELDDGPQQLDPYYGHVFDKCLFTCQNSQDENVRVSAFEALGMMIQHGSPNATPHILSRLTSILEHLEVNIEKHKANPSYGQEFYGLYTCACDVLVVIIQRVDAEIRPFSDRIMQCLLNIFSTGHTTAGEEAFLATGALAGAIESEFKKYMTPFYPILIAGLSNVQEHAVCASAVGVVGDVCRALGADVNVFIPDIVNQLLNILRFPNLNRTVKPPVIAVFGDIGLAIEGEFEPYFQHVMEMLLQAAQACVSVQVEDEDGIEYMNQLRESILEAFTGILQGLSSHNKGHLMVPALQGVGQFIALLAAESNRTESVTTTCAGLIGDIASILGQQAKPLLKEQFIQVLLVDCSRIQEGQAQSVATWAKQLVDEALRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WKE7</accession>
    <name>A0A6G0WKE7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine aminopeptidase S33 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_014333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000191">
        <property type="protein sequence ID" value="KAF0727709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WKE7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009180"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47533:SF4">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47533">
        <property type="entry name" value="PROTEIN CBG21859"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="1">
        <location>
            <begin position="74"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0727709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="329" mass="35734" checksum="C18D6EB63214656D" modified="2020-08-12" version="1">MARTEATLTKTLENAPLSHGSSASPKASWDYTINQTAATAGTDATLTKTLEKVTLKNGEDVWFATYGYPNALDTFFLVHGAAGTHEDFKHFSPLLANEAYNVMAVDLPGHGLTSGDAAGGVDLTEARIVDAMIETVEILAAREPLRRFFLVGHSFGGATAMQIVARGQPSSIAGLALINTSGFRPHVIMRPYWVIVLLYKLLVASSFTRMLTSSLVRFLLVTHGFSKTLTSAESAYTFHRTATMDFDAVKESASLIHEIKLPLFYANARNDRVVEKAIGDEVFAILQPPARLEYDSGGHNIQKTRAAELSATLHKWAAAVPRVLKRVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WKU3</accession>
    <name>A0A6G0WKU3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_014156</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000186">
        <property type="protein sequence ID" value="KAF0727892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WKU3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015178"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052410">
        <property type="entry name" value="DRC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24107:SF2">
        <property type="entry name" value="NLR FAMILY CARD DOMAIN CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24107">
        <property type="entry name" value="YNEIN REGULATORY COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0727892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="445" mass="50409" checksum="73F697B5E24C731D" modified="2020-08-12" version="1">MSKNYSPLPTDIVMTISRFLPTSTDLFSFLEALRGANHLGPLESLRQLALSKETSELWPSLEISPKDESLTPSARKALESYAMHYNLVQVHDLSCIQWLRLDRFDPNAEWHLSWKDHIDVDTWNEWTKVQITKIDITMCQEDTYMFQETFEPMLSQLIYLKAIKACFSEPLMAEMILSFAASSAELTHVELQLDHGSYLTITPTMARNVIQWFQRQSVQVLKFSAWSVQIEDAQLRDEFYNAIFSCPTLETLACTSSSMNDIDFTTLSLPMHSLQIQHCHLQSYHIDALASQLVSSGIRHLALRDVFYQSNAGTVRLFQALSVSSVEVLDISENDFTDETWRTLAPLLRRSRIKTLLLSSVEMSSEGAMCIAKTIQENDSIQVLDVSHNEIGFEGLRKILLAACDPKRPVQMHSIQCIDCGVTLTDEEQSTIQAVAATRGVEISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WLD3</accession>
    <name>A0A6G0WLD3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_013940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000181">
        <property type="protein sequence ID" value="KAF0728112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WLD3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019507"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF214">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="240"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0728112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="498" mass="54169" checksum="0C2EAAE242952764" modified="2020-08-12" version="1">MAVDLCSTTLTGISAKSSSFPWCSIWEGLGNRRVDIAKLKKVDCIDQTCQFVLKSIADYQATLASTGISCTVTDTSTGSLINITVLGSVCDGIAVTKTAIPSNFQNITTYTPSPISFLTPAPTFLSTAPTPAIPSTTTTPSSSGEETKSSNSTGIVIGVSVAAIALIAAILFVIWRRRRAAAAGQALPSNQPYGRLNSPQPNSQKPSSGAGTTSSSHKDGNAFELDKLDLDMHRVTWNEVHLVKMLAQGAYGEVWLGEYLDGKIAVKRLLPTKTTKQDLQKFIYEIHLVSKIDCPYVVQFLGVTWSKLSDMMLLAEFMDGGDLRQVLEANNTKRSFTWTHKIHCALNIAEALVFLHSMDPIVIHRDLKSRNVLLDADFNAKITDFGIAREVDETTLTAGIGTYRWIAPEVLVYGHYSESADMFSFGVILSELDTEIVPYSDLRNGAGKPYQDTALLAKVMAGELLPSFSPDCETWFVHLARDCLALDPLDPLDRPTAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WLJ0</accession>
    <name>A0A6G0WLJ0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_013970</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000181">
        <property type="protein sequence ID" value="KAF0728144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WLJ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018807"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005629">
        <property type="entry name" value="Skn1/Kre6/Sbg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361:SF1">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03935">
        <property type="entry name" value="SKN1_KRE6_Sbg1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026058633" description="EGF-like domain-containing protein" evidence="7">
        <location>
            <begin position="23"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="694"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="725"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0728144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="764" mass="84514" checksum="DD397D058CD08E97" modified="2020-08-12" version="1">MTKSTPWSVLTVTLLQASAVYAIDHDFEAYPTRSGIGAWVDIDTPSTAMSKITSRGEKWDLVMSDEFEIEGRTFQAGKDHLWTALDIPDGVNAALEYYNSSNVYTKDGKLINRVDEGPVNVTYFNQWLEHPAYESTTLHYTAGMMQSWNKFCMQGGLIEVAAKLPGVINNVTDSEHKSVTINPNALGVFWKDGVRYNLTDQDLIKDINFYPTWPGIWLMGNLGRALFTASTTRMWPWTYDECDRDLEPHQIISACNSNPGYGLNPNQGRGAPEIDILEGGGAAISSSVQIAPGMPDEYRRTDVNVTIDGSIYCVYGKGCQTPGANIPDAPWSVFAPRGHKNWYQGLRYATNKRCKPVATDIQTYEPVIAAQQNPLKLIVNNTYVKTQMSAARDVNADLSLINSSTTKHWGINYDGTCFPIANGYIGAYLCDPDNKNPKCTAPRKDGVAPTKQMDPFNYQMDAISVNWDIGHEAYVMFYVYQVEWVTGSNGYVRWSLFDSPLFEIPASALTNPPQAAEGSGKPRNPKKIMIEEPMYLIFNVALAKAWGATPPNIDAGACRGNATSHDPYGTYQYNRTMSICDSFPMYMEIDYIRVYQDQSSMFIGCDPPTHPTKQWIDSHLTWYTDKNNEMIRVDGGATCASDADCQGSIATEPTGRCLERRCSCVKGYGGPRCTKFTGSKSFNVDSPTYFGPSIVYPAVLTSVVIAIVALTTVMRNRRLVAASDLAAASRKPKNNDADDEEPAQPASRRFYAPVQAAGGLKQVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WMC2</accession>
    <name>A0A6G0WMC2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Ae201684_013812</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mediates influx of magnesium ions. Alternates between open and closed states. Activated by low cytoplasmic Mg(2+) levels. Inactive when cytoplasmic Mg(2+) levels are high.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Mg(2+)(in) = Mg(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29827"/>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000178">
        <property type="protein sequence ID" value="KAF0728449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WMC2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014880"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000004">
        <property type="entry name" value="Magnesium transport protein CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494:SF1">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="530"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="568"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="154"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF0728449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="592" mass="68193" checksum="182767FB826DD6CA" modified="2020-08-12" version="1">MATDQDKTFYTALASPSGNAQPRDFESVVQIEIPPIVPPADEKWIEVPVLPQFTYQDAQAMEWDYANVTKQTLRQSFRNHAGSKTSQLSYRPSSEFGDPDRETKEELGVLLDPFYDVTTGRLRRMFKHFTPYGKEEVTYDEFQNGLLALGISVPSSMSFREFVRKVDTNGDGVISLDEFVKVVQMIKLAHLFRPEHNQVDKHILRVVDYSPTNMHAVAPVTKLQSFMFSAKPTWAKVRWVHLAGFHKLDDLNMRRLAIKYQLHPLAVEDCLNQNDKIRCKYEHYEDHAFLVVPVIRALSLEKRSHIEDYIAAYRQDVFNKRQALMKDGIIEPPSVESKDSLTAKLNELKIITQVPDQLCVFVNLTTNNVLSVQADVDNDTSAFMLWDALFDHNMEKSYSKVRSHDAPFLVVSILNAVVDEILPLVEVFEAKFELQGQLLRLEGIKFDTMRFALAKKQLRALEKIVRPLLDLVQDHLLDQEEFNHGEAKNYLRDVIDHLKQMTTDLQSHYQTLAALVEEDKQIRAQSQADALYIMSVVAACFLPGTFMTGIYGMNFDNLPELHYENGYYVWWAVLCSIILLLLGYLKFYKHWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WMN9</accession>
    <name>A0A6G0WMN9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_013570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000175">
        <property type="protein sequence ID" value="KAF0728609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WMN9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010911"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="Ribosome recycling factor, RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0728609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="259" mass="30457" checksum="305563D4DD6EA876" modified="2020-08-12" version="1">MAQPRRMSLLQRFFYVAQNGNKRVDAWLDKHMIGLPDPPLTEEERQEQERNKIVDLSTLTLADHIRFAREAWEEYKSTFRDDYEHKDFIGDGGKKLEESLKEQREKAEQHLETHHPELKQQLTTFSTEVKSTIEETKAQVQVHVDEMKTQAKNIDVERIPEHVADAVNAVRNRPMVEVKNDLEEWAIDKLTVGRLTLEAFVDGYKLGKDEEINRETPLLKELADRATERHKDFIEEKRKELFEKVSELEVKTRSKGHDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WN63</accession>
    <name>A0A6G0WN63_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_013367</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000172">
        <property type="protein sequence ID" value="KAF0728795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WN63"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021797"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
        <property type="entry name" value="FYVE_like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="5">
        <location>
            <begin position="263"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0728795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="389" mass="43605" checksum="CC8743792FF1AB4D" modified="2020-08-12" version="1">MESTGFQCSPLDLDDVRQLKQLARQVAQEAVKYAFFTTSPINWHLSSDDQGIQIYSGVDNTAPPNVSTWMSVSTLQASLDDVARMSYCESTAEYKQFIDASGSIFTDGARLYNIERPTHDNPHDFIGVNWLKQTSKLNGMGIKPRDFCVVEIHQDTKIQGTRAWVRAMRSIKLREEPYWMNSPGVIRGEIYRFGAVFVETNQPNLLQVFHLTQINPKGRVNDLIVKFHASRYISSMAKKLSGMLRSYRLSCSGFKNECDLVPKASRQRCGLCNKAFNLLLPKARCRKCGEVVCWGCSKVWLVRDCGIPTKRRVCTACCVNVASDIISSTALSTPEEEKKLFIVDDDDGEDESVDDVGSDVGESLVCAPQHSSSRHVYRPDAAKLLKAYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WNW9</accession>
    <name>A0A6G0WNW9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_013320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG101 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000170">
        <property type="protein sequence ID" value="KAF0729021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WNW9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001989"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012445">
        <property type="entry name" value="ATG101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13292">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13292:SF0">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07855">
        <property type="entry name" value="ATG101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0729021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="181" mass="20679" checksum="853C2E8722965429" modified="2020-08-12" version="1">MASVVYPGSSSQVTQHELEELRVGVSELAECVACLLHTILFTRAPGPVRPGEAHCRFRPITYAYCPVAEVTRKVDAAIVQFQRHMTRHHTNGHRISIVFYETRVNKALFGFVQNEEKVVWEKWTLPIRVLVHPSTNLDEYHSQLENQLRHGMLQIISIVQTDTQAIPMGIYDYDLIVNDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WP94</accession>
    <name>A0A6G0WP94_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WRKY19-like zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_013182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000167">
        <property type="protein sequence ID" value="KAF0729205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WP94"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021881"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056866">
        <property type="entry name" value="Znf_WRKY19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827:SF1">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24906">
        <property type="entry name" value="Zf_WRKY19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WRKY19-like zinc finger" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0729205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="159" mass="17562" checksum="C1A6AD42678A3CAF" modified="2020-08-12" version="1">MHQHGIGEWQMQSHKCRSYCSAENCLNQAYARKLCVKHGGKRSCRFEGCQANARHAGYCCRHGPQVSKRRCQTEGCTKFAHARGLCVRHGGGRRPQYDPNEAMSASEINLDEMLMSLDAPSSLTDVVMSQDESCAVEFTAEEATALAYFLSPNPTVTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WQI4</accession>
    <name>A0A6G0WQI4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_012707</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000162">
        <property type="protein sequence ID" value="KAF0729646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WQI4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018854"/>
    <dbReference type="OrthoDB" id="62666at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0729646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="97" mass="11530" checksum="5C7D2CAF9917E34B" modified="2020-08-12" version="1">MNYYHQQLPRHQRTEYIMRLLYDSYASNLKHANPDVFAALALKIERILLRSFPNDVDIPPQVLEAQMRHVIERILFSKETVALQPNNYTVDELLYEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WR58</accession>
    <name>A0A6G0WR58_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_012548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000159">
        <property type="protein sequence ID" value="KAF0729909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WR58"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006388"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="438"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="499"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0729909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="699" mass="79943" checksum="732EC4C892CC8030" modified="2020-08-12" version="1">MGWYARRLIRKLLLNSSRLLACFAAGCVFYCEMMGSTANKLLLLGTSTPPANTVTYASHLFPLFLPTLVSSTATINKTLQNVMVNQTSTPFVVYLDGDKPTGQQPQQQPTLQSKFCHETTAYDYLYYDAYLDIVLTELFAGFGGWEASKFWVIVDCTYDGRVFSDSTVIKFYLLDKAMTQITTVMLQTLSITRPQMQLISSGGAAMWTKTNLKSMKIGDDGQVTSSESASYSVAIGFTFPYESTNFYPVVLEDSVAPDGQWRAQVVSTREKFLFAGTSGIYRRAPSIQGSFNYFYWELPSDPLEFVAKIQFVGVMVFKDSWGWFRCFLGIGIGSNIAVNFGVSLLVVINMYRENNILWIPDVYPSIQSRAMIRASLLLLDCIMNSWWYPYQWAINQGSKRNHWGGTLDFNESSRADGLMAVLAITYLTAKTLHVRVQLVIVVYIYAMCYYMRQSVIASCGLFLEKVTPFIKKNYFENIFPTGNNAMDLWAYHENRSTNFWLIANECTYLIVATGVSVGYVLLTKLWIGRLRDKITNLIATLHFVRWRHVRPIIQYMVRHRMTNPAAAMAHIAWNRRSTLYHELNEWDVENTNVERCTGSILEHINGFVALTKDYIYEGGRIYVSPSGVWLLGFVIVNDQYVVNINHYIYLLFNSLCGQTYFKVYGFLLKDDLVTQRTYRIVARDIPPRNVWRVSLKRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WRM1</accession>
    <name>A0A6G0WRM1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_012454</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000157">
        <property type="protein sequence ID" value="KAF0730056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WRM1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003379"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06548">
        <property type="entry name" value="GH18_chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="2">
        <location>
            <begin position="11"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0730056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="498" mass="55044" checksum="BA53C3128ADEA06E" modified="2020-08-12" version="1">MLASTTAAAKLKSVVYYMEWAIYQRDFKIFDLDWSRITHVNYAFGRPRDDGTVDLFDTWAATDKRYLDHNDSWNDAGNNVYGTFGQGNKMKKQFRNTKFGLSIGGWTLSDKFSNIASTDAGRRTFAASAVNLMLDLGLDFIDIDWEYPVEGGNPSPPVPHRPNDIANYVALLQAIRDEFKKLPFQAQLSVASPVGPANYRHWDFAKICNLVDHINVMAYDMAGSWSAYTDHQANLYQDPNHPEGDVYSVDGAIQDYIKKGCSPDKIVMGMPLYGRSFENTDGLYSKFTPPSNRGSWVAGNGDGAGVWDYKALPLPGAVEYFDEKLVAAYSYDADQRMFVSYESPISLAAKLDYIKKQGLGGAMFWAGDADARAGSARSLIAQVYNTFGKNNMAFEENNLHYPTSKYDNIRSGDGANPEPNPRQPVVVPASWSRQPVVAPSVAPTPAQPVAPVSPPASQSGGSSDCNGNRNVCFWPGVNQVLPYGKKDCKLFPSFKWCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WS00</accession>
    <name>A0A6G0WS00_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">HVA22-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_012260</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000155">
        <property type="protein sequence ID" value="KAF0730258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WS00"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009439"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF161">
        <property type="entry name" value="RECEPTOR EXPRESSION-ENHANCING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0730258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="134" mass="15148" checksum="2384CAB6905BA87F" modified="2020-08-12" version="1">MGALLSRPVVSGVGVLYPAYASFKALESPADDDDKQWLTYWVVYALTTSVEEAAETVLQFFPGYYVLKCLFLVWLMLPKTRGAAIIYRSFIRPLLKKYEPLLDAKLIALRSAADKYVADLHARVQDTLRTKLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WT11</accession>
    <name>A0A6G0WT11_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RNA helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_011987</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DDX59 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000153">
        <property type="protein sequence ID" value="KAF0730565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WT11"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004446"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00268">
        <property type="entry name" value="DEADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23022">
        <property type="entry name" value="zf-HIT_DDX59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044742">
        <property type="entry name" value="DEAD/DEAH_RhlB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF13">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="9">
        <location>
            <begin position="80"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="111"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="316"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="80"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0730565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="531" mass="59271" checksum="8103FD8EFAEC63EF" modified="2020-08-12" version="1">MDEATDDIVQVTDKQRFPLEGEPVCVFCGRYGEYICDKTDEDVCSVECRDKALERAANRDLQKEFGISVTGAGLELPLVTAFRSLNLHDDLYYNMQKEGYHHPTPVQMQVLPYALQHHNLIVTAPTGTGKTMAYLIPLVTLVMEHRLDVEEHRILGLVLAPIRELCVQLEEQAKTLMKGIPKMKTALLVGGVPIPNQLHRLSQGVQLVIATPGRLHDLVTEYSVDLSHTLCCVLDEVDMLLEKDFAGIVVSLLKCLPDNKQFILVSATIDDKVHAFAAKHLHQPIFISIAGAQGVNVHQSVHYMAPEARKHHLFQLLQDKCSNVDMSIIVFVASKQGADMLAKAIVKSANISALSIHSDKTQSQRLAALNTFVEGTAQVLVSTFLLGRGMDLLQLDEVVVFDLPPTAADYIHLIGRAGRNGAPGAATVYICAENAPIFGELIPILRSGQASIPHEMLEETTRQRIKAYTQRKIRVQDESKRAFRATTQHLTPAQQQKTWRQWTENEPKRKVIVLEQAETQHKKFKFIKPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WUB8</accession>
    <name>A0A6G0WUB8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_011638</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000147">
        <property type="protein sequence ID" value="KAF0731092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WUB8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000622"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0731092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="389" mass="43958" checksum="060C3796FAA35ED5" modified="2020-08-12" version="1">MGFALVVLDVMHREGEDNLVHATPQLNEELLLLRGMFAAAAGACRTLFLECVEHAMLKMHLHAGYVDQGDLLFVLLCMDEKYHANYLKSCAQRTVSVLNSVFGPPGIKLEKWDKTKLNSTCKALFRCFDAERSMVDSVISFLFPRGIPSKHIDIDTMIRLHGHFSSPPPESEFRSVMYVVSLLNNTHDEKWSLYLLFPRHNGASASAIDAATSASRELLENVQKSIDVDENKHVYQAQWYHVVAFDRVGQAVLHRCQGIATAVHCRFVDEIERMRGDFDRSDALHRVVRSKVTVQPTKLPFPSEDPLLKIDSSVPTMDVALLSSRYSIFRPEATVCQSQTKQMICDEVDGTMIYIYGQRYAAWEFFACVEANEAAEALVDALWDELVSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WV80</accession>
    <name>A0A6G0WV80_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_011353</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000143">
        <property type="protein sequence ID" value="KAF0731452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WV80"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006714"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051279">
        <property type="entry name" value="PP1-Reg/Actin-Interact_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24112">
        <property type="entry name" value="LEUCINE-RICH REPEAT, ISOFORM F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0731452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="491" mass="54087" checksum="22535E4D617F7D5B" modified="2020-08-12" version="1">MKRRRLAPALVTCLPAELLQYIALFLADSETFFACLDAFQACNLLGDLLCFTKLRETMEPCCLWPQVRLGHSPTPSELASLEIAVKYTTGIQLGGIFDVHWLHRPSFAVTTISVYLKACPFEVPSLAMVHDWSIQLPRLSVRHLDIPAIHVEALQPLFTAESSLSSLRLDLGSYPDALETILAFLRVSKLTSLTLDSSTSCCTSYSIPPHLFPHLISWLRREPVESLCLSYLDFRPVELLLPAFFDALALSTSLEHLTLKHSTLPVFSCQSLPPLKNFAVDECFMSSQAFSSLCSALNASDISSFTLTRHPVTWDASRGSIGDLVAGSSKLTTLVLRQMTLGEEDARQLCAGLKRSNVAELRLQDIGFRGRGLQILTEALPAIKSLRKLGLHGDFIGDRTCRCVGKILRASTLEHLDFSRNNITDMGAFHLSRGIAGPTKLKRLLLDYNRITVTGASALQRSFRRRTSISLQGNAMTPQDIAGLCGIAPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WVL7</accession>
    <name>A0A6G0WVL7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_011203</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000141">
        <property type="protein sequence ID" value="KAF0731583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WVL7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002647"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000026">
        <property type="entry name" value="TBC (Tre-2/Bub2/Cdc16) domain family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="173"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="519"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0731583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="539" mass="61275" checksum="882AB30184D801C6" modified="2020-08-12" version="1">MHQVPMESPPKRRFFSMERPRTSSIHYQAGQPATSSSCDCAGPRTFRCEYIATCESPSSPSKGRGSFMHHHPVKEIEMTSIVGSKKKKWEEKFTSKEWELEWLQKWRKRTMEDEAQHTTVDDLHTTRQSLYGDPKFGSDRPGFRRRSLSDAGGMGFMGFSLGQWQVDSMLRSGIPIEYRGRVWWLCSGAAQKRAAAAPADQYESLLWRADEVLVDVANEIEKDLYRTFPREPDSREEREASISELRRLLSMYSLRNPKVGYCQSMNFLAAMLLVYLGEEEAFWVLACIVEDLVPGYHTKSMVGSRVDQHVFAALVEQKLPHVAHHLQRLHVHLAPVTFKWFLCLFVNTLPLETTLRVWDVFFSEGSKVLHRLGLTILKLLAPEILKADEAFDVYEMLKLSPRTLGLLLLPHRKVVAHNSAAAQWRKQDDCYCDTLLRLAFDKSFLGPFPYSAIVDLRAAFHVLVEEELAESERAAPRCSQSGRDEYDFVDDFKSDEMEYDFLAASGGTTGGGCLAEAAKGASTATTTERPSSLIENYWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WXW4</accession>
    <name>A0A6G0WXW4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_010629</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000135">
        <property type="protein sequence ID" value="KAF0732343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WXW4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001139"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000286">
        <property type="entry name" value="Heat shock transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="6">
        <location>
            <begin position="66"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="24"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="158"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0732343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="338" mass="38799" checksum="E11E27C1DED9E7C1" modified="2020-08-12" version="1">MDHSTPTPPSSFQLHIQLPNTYRHHQHPSHHYYNTPPVGTPTTPDSVGHGFFSGDESPSESRKAREMAPFLRNLRNMLDRESPEVLRWNKDGTAFEIHDMDEMMNTVLPKYFKHKKYTSFQRQLNYFNFKKWTKSRANVCTFSNELFTRHEPHRSTYITRKKSMSGKDMAAASDDSADESRRGYDSPCSSACDSPVQRKDHLSRVDMSFQSMSLHKPTSSRMTSPYENKHLTRVMGSAGVRRKPRMEVHVVEDIQWLDNDLDSLRDSMTSVASSATSVGGEWDDNELNWGDWFPYSDAQLYDNQYTHHPHHSTSMASTSSQPLRGGLPNNQVTFFAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WXY7</accession>
    <name>A0A6G0WXY7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_010431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000132">
        <property type="protein sequence ID" value="KAF0732441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WXY7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003196"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0732441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="497" mass="55166" checksum="033FCCADE9ECE34F" modified="2020-08-12" version="1">MKEILLEEYEVPPPPPSKRRRRFLWAFGIGVVVVVVLSLAVLLIPGHREVETSSAVGIDVVNGTAKLKYKCMNHTHWLPESNLNKVHSQTAAALANVDNPSNNVLVDSRTNTTVMFRGRVLSLQECAIMARAYNRSFFSWESGRQVCYLNDPTPSMELDIGTNYDSSDECFRMCNRTLQCAAMTFVDGECTFYRPTGNKATIQSGWILPPPAPNSTNASATITPPRPFSKALSVHFYVTAHQDDHELFLAKQLYASFRDPFTKVVFIYTTAGDANRTDGWWPAREVGTLASSKFFVDDFGYYTSSDRKDESIKIQGRSVQRVTMGNFVSYFMRISETGLNILLRNQSNNNVVLPLGTTAATSAGYSSSLDVQNVIQEILRNESAGIATVGAYTLEYATNGNDHELHKGTGLIATNAINAESRLAKCTSKTYLFGYETWLTAVNMQDPELSTQRRMWIALAAAIEGVYSKKDVWSNHAINLGRNYISRANVTKASCSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WY61</accession>
    <name>A0A6G0WY61_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_010438</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000132">
        <property type="protein sequence ID" value="KAF0732448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WY61"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004782"/>
    <dbReference type="OrthoDB" id="66261at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.239.10">
        <property type="entry name" value="Elicitin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036470">
        <property type="entry name" value="Elicitin_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026216226" evidence="2">
        <location>
            <begin position="30"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0732448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="288" mass="31436" checksum="F5B1F3209A66B34B" modified="2020-08-12" version="1">MKSIAFAAVFGAVFAAASAPANITRCTEADYHKIQADAKWSLYRPLCAHVLGLSLSEFDNHTSPTEENEAKLKDSDVCKWFYGDIQKYARRANCYELDLIGSNITWDMVVELMDVEAVPKVQNNCSKVELTGAFTGLAAKSSFYKCVGTSSKNLFTVPDANQLALFRANPACSDLFNDFQAVIDGLPHCAVHGDGTDVHAFRKLSWNVTLDWLNILSSSQTAPAVPGAVVFALNYVPRLDGHSIIVLATGGLFACAIIAFAAFFIYKKQVVNAKPASRREERVGLLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WY93</accession>
    <name>A0A6G0WY93_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_010466</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000132">
        <property type="protein sequence ID" value="KAF0732477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WY93"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014581"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01100">
        <property type="entry name" value="APPLE_Factor_XI_like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000177">
        <property type="entry name" value="Apple"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33946">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33946:SF4">
        <property type="entry name" value="COAGULATION FACTOR XI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14295">
        <property type="entry name" value="PAN_4"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00223">
        <property type="entry name" value="APPLE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026080128" description="Apple domain-containing protein" evidence="4">
        <location>
            <begin position="23"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="5">
        <location>
            <begin position="28"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0732477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1052" mass="110101" checksum="EA68EA9D0C6F0035" modified="2020-08-12" version="1">MKWFLYAAAAAAVSFAVTPAQAATTAQCATIEENTDYPGNDLASTQQSTAEGCCADCANTTGCKVYVWNSDTKTCFLKSQPVGKSYYPGARAAKLVLSPGTCSAIQKDTDLPGNDIGDALQVTSVDQCCTYCANTQGCVAYVLSPANADGTAACHLKNAKGTPSSSTGAQAAYLVSTTTSPTTAPTTAPVSVVPTVAPTVAPTTAAPTTAPTTATPTTAAPTIAPTTAAPTTAAPTIAPTTAAPTIAPTTAAPTTAAPTTAAPTVAPTTAAPTTAAVTAAPTLSPTSAPSSSQCAAVQPDTDYPGNDLAVLQKDTVADCCAACSTTSGCKAFVWVMRDVGTCILKSAIGQASTFTGAVASYPIVPTPAPTPSVCSAVENDVDYAGNDIMSVDRANYQDCCSACKSISGCSLYVWSSGTCYLKSSKGEKSSAPGAKAAVLPVLVGTTLLSNVKSEVFGTFPLPSIAFNYISGGQWINQDTLSVVNQQVEAFIIKNKEANFSHDAAQTPMFTLEADLGLNAYINVTSRGECATLTAAFGSNFFTYLPNLLYCFVHLNTDDTSLQMLTATGQAIVFPQNLDDVYKSSTQSNVATNDACVAACKTQGSCAGVLYSSSAKTCTFYQPKSATSADVVAGWVNPAVFYVDNGSIQYSKMPMMSLPKAYVTTTMPSITSVDACATYANSKKSTLFGYNKTAKSCVLYTPTTSKTKSLSMPNTPSVPVVLSGAFGSDVTSASQSASSSLDCYKLCLPSKNNCFASVFDSTAKTCATYQAISDVSTTLGWIIPKTLPTSMTTVKQVDFYVTAHQDDHELFMSVPVYNSLKTPTTKAVFVYTSGGDAGQTDGWWQAREFGTLAATKAWVNMFGAYSPVLKNETVLLNNHHIVKITIGNTIHYFLRMSEDSLTSVLLSNTKQAPMDQPKETYANAAAVKATIKAIILAEATKVAKVTASYSEYLTDASNDHALHVATGQITAELLNSDALFKSCVSQTPYFGYQQWLDDVNMKDPESTAQRNIWLNLGLGILTKYPRNIWSDHSMALGRSYTGTPLPKTKACKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WYX0</accession>
    <name>A0A6G0WYX0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_010119</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EamA transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000128">
        <property type="protein sequence ID" value="KAF0732788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WYX0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015237"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004626">
        <property type="entry name" value="RarD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00688">
        <property type="entry name" value="rarD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911">
        <property type="entry name" value="ACYL-MALONYL CONDENSING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911:SF137">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER G2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="9">
        <location>
            <begin position="9"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="9">
        <location>
            <begin position="155"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0732788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="334" mass="36429" checksum="43C48B8AA4A3B89B" modified="2020-08-12" version="1">MQPVNDLTRGVCNGVTAYAIWGLSPLYWKTLADVPAMQLLGHRIVWSLPLLLVVLCVKGELDALLHAVQAWRTMVVYVTSAVLLGVSYLLCLWSVNEGFIVDLSLGMYVNPLVSVLLGVIFCKEVLTKWQWVAIVLAAAGMLVMAIDYGKFPWIALSIALDYGLYGLVAKKAPLPPLQGVTIEFTLLTMPLVAYLLVMEHQGRGAFGHSGPTQDLLMVGLGLLTVVPQVLFAASAQSIPLSVLGIVQFLGPTISVLLGVFVYHESFGLVKGVAFGLVWVALILFTMQSYQHAKKESTTEWTDTSELELSSPQVLSNYSITMEDDKSQIRSQCVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WZ21</accession>
    <name>A0A6G0WZ21_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">S-adenosylmethionine:tRNA ribosyltransferase-isomerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_010140</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000128">
        <property type="protein sequence ID" value="KAF0732810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WZ21"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013126"/>
    <dbReference type="OrthoDB" id="1448at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051075">
        <property type="term" value="F:S-adenosylmethionine:tRNA ribosyltransferase-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:tRNA queuosine(34) biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.240">
        <property type="entry name" value="QueA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1780.10">
        <property type="entry name" value="QueA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003699">
        <property type="entry name" value="QueA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042118">
        <property type="entry name" value="QueA_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042119">
        <property type="entry name" value="QueA_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036100">
        <property type="entry name" value="QueA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00113">
        <property type="entry name" value="queA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30307">
        <property type="entry name" value="S-ADENOSYLMETHIONINE:TRNA RIBOSYLTRANSFERASE-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30307:SF0">
        <property type="entry name" value="S-ADENOSYLMETHIONINE:TRNA RIBOSYLTRANSFERASE-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02547">
        <property type="entry name" value="Queuosine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111337">
        <property type="entry name" value="QueA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0732810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="350" mass="38943" checksum="F51C409A2C67AC15" modified="2020-08-12" version="1">MSAKALYDFEIPPARIAQRPRPFGEQKLLVFHKEKNDIEHTSFESLPDLLQPGDLLVLNDTRVVPAQVRLVEPIVGACTSFLFLDPLCAVTTNMEVLLSSRVEIGSVLHLPGGLTFRVDELVGGDPEVHRGSLFGLEQPLHEYLAGIGEMPLPPYVERVPDKEDEKAYQTSVAQVPGAIAAPTAGLHFYPALLERLRKVGVEHVCVTLHVGYGTFRSFTTEFIEQHRMDRERYHVSVEAGSAIHKALKEKRRVIAVGTTATRVLETCAESFLAPEAPAELSGEASLFIYPPYQFKVLSGLFTNFHYPKTSVLTLTAAMCGSRDILIDQIYKEALDRDYLWYSYGDGMLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WZI6</accession>
    <name>A0A6G0WZI6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sidoreflexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_010044</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sideroflexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000127">
        <property type="protein sequence ID" value="KAF0732935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WZI6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010715"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015075">
        <property type="term" value="F:monoatomic ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990542">
        <property type="term" value="P:mitochondrial transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004686">
        <property type="entry name" value="Mtc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00798">
        <property type="entry name" value="mtc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153">
        <property type="entry name" value="SIDEROFLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153:SF6">
        <property type="entry name" value="SIDEROFLEXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03820">
        <property type="entry name" value="SFXNs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0732935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="331" mass="35968" checksum="ACD4498DD29647E5" modified="2020-08-12" version="1">MSEAAQVPPFSLDKPRYDQSTYFGRWKHFSELVSPSGFLLSDKEIDNAKGLIDGFKNGTLQAGQASDAELWNARRVCDMVFHPQTGEKVPVLFRMPAFVPVNIPICSGMVLAPPTLFNTVFWQWINQSYNAGFNYANRNASGVDDTTAIAKAYASAVAISCATSVGLGKAVEHASFLAPSARIILSKTVPFVAVAAAGAGNAVFMRLKELTDGIDIMDNEGVVRGRSQEAGKQSLTQVALTRVALPMPILLFPPFILEAMKTAKMLPKKRFGRVFTEISVVTLCIWGAFPAAIALFPQYGTIPASEVEPEFKNLKNSKGESITEFTYNKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X0G4</accession>
    <name>A0A6G0X0G4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Lysosomal dipeptide transporter MFSD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Major facilitator superfamily domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">Ae201684_009840</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26 27">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="23">Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79415"/>
            <dbReference type="ChEBI" id="CHEBI:192470"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)</text>
            <dbReference type="Rhea" id="RHEA:79367"/>
            <dbReference type="ChEBI" id="CHEBI:229968"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)</text>
            <dbReference type="Rhea" id="RHEA:79375"/>
            <dbReference type="ChEBI" id="CHEBI:229967"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79383"/>
            <dbReference type="ChEBI" id="CHEBI:229966"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79371"/>
            <dbReference type="ChEBI" id="CHEBI:84315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-arginyl-glycine(out) = L-arginyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79391"/>
            <dbReference type="ChEBI" id="CHEBI:229955"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79411"/>
            <dbReference type="ChEBI" id="CHEBI:229953"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79379"/>
            <dbReference type="ChEBI" id="CHEBI:229964"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-histidyl-glycine(out) = L-histidyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79395"/>
            <dbReference type="ChEBI" id="CHEBI:229957"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)</text>
            <dbReference type="Rhea" id="RHEA:79399"/>
            <dbReference type="ChEBI" id="CHEBI:229954"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79387"/>
            <dbReference type="ChEBI" id="CHEBI:229965"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79403"/>
            <dbReference type="ChEBI" id="CHEBI:229956"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-lysyl-glycine(out) = L-lysyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79407"/>
            <dbReference type="ChEBI" id="CHEBI:191202"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="24">Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000124">
        <property type="protein sequence ID" value="KAF0733278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X0G4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002759"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002760"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052187">
        <property type="entry name" value="MFSD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23512">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23512:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0458">Lysosome</keyword>
    <keyword evidence="6 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 25" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 25" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="472"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00044919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00044924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00044985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00045018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00045709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00046376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KAF0733278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="512" mass="56620" checksum="0DD227498C0095FC" modified="2020-08-12" version="1">MDRDTTKRYVLVFSSMLVMGLMYCYDNPSALKNQLQQHFHHLPKAQFEYLFNLTYSLYSVPNTILPLIGGVLIDRVGVHLMAVALAGLVLLGQLTIAVGCAAYDFDLILFGRILIGLGGETLSVAQTKFVVKWFNPSELAFIFGVVSSFTMLASVLNYKWSPWIADHYHVTTALWVGVMLTGVSFLASVVLCRLDMSSPTKPTPSTDRVSFRDIRQFSWIFWLVVFKCFLGGCIMPFNNTAVSVFLERDFFQEPPLPCQRCGEGEYKIFCDKISSHCPSVPPFAWPLPQLSKNCSIETAFDQYRCSKDPPYIDDDAINCDDKAWREGPFTQKYCKTKGDASERAASAMSISPLVQTLLGPVAGAFVDMIGMRPHVVFVSEAAVAVAHSLIGFSHVPVTTPLLLFGVSWSVVGAAMSSSIPCTFFRHILADLSCSRRADKSRGDCVRTPKHRRKHGVGGRSLPRVGHLCTCCVTNVVFAVVFIAMDAAGGYRLSRRAEKSDKLTDDASEPFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X0Q1</accession>
    <name>A0A6G0X0Q1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peroxisomal membrane protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_009660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000122">
        <property type="protein sequence ID" value="KAF0733414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X0Q1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001285"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019531">
        <property type="entry name" value="Pmp4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15460">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15460:SF3">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0733414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="24562" checksum="2E20CBDA3DDF8A2D" modified="2020-08-12" version="1">MSDVFNDLLCLVRAFRNGSYYGTKIRAPHAFVMVMLFQNKPLREKLRGIVKLTFEHTKNLAYFVGVYKGVLLLLKETDHAITGSRVLTTTGLNPIRPLHAAIAGAAGGYIVWSKYSGVNYQIVLYLFSRVLIGLVKLASEKGLPIMKDYSFKQVYPVLVCATWGVVMWLFEFHGHVLHPSLSKSMDFLYHESNSWATLEDFLPSPATVAVLALTWINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X1C3</accession>
    <name>A0A6G0X1C3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_009523</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000121">
        <property type="protein sequence ID" value="KAF0733588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X1C3"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0733588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="156" mass="17165" checksum="2615444FB30EE956" modified="2020-08-12" version="1">MCLGYSTMVIDDQDSLSSTIPYFASRCPFSCYLAREVRRADSTMRLASFRTAHLVRDLDAAPWSCLPIQPPVVSRSSAIRCLISVFVAQFWQFPNLRSFDVPATSSTLLTNQASSSHFAVSSLELCVAAAWFPLHELQVILGRRASFCGLSAGSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X245</accession>
    <name>A0A6G0X245_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cation efflux protein transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_009147</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000118">
        <property type="protein sequence ID" value="KAF0733970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X245"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008275"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040177">
        <property type="entry name" value="SLC30A9"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13414">
        <property type="entry name" value="HUEL-CATION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13414:SF9">
        <property type="entry name" value="PROTON-COUPLED ZINC ANTIPORTER SLC30A9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="7">
        <location>
            <begin position="119"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0733970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="527" mass="58668" checksum="3AD5AC8C1E627E80" modified="2020-08-12" version="1">MAQKRSLAFRFRCIHVPLDVLRMKATARHNTVHPRFWTSLSADQNQSPEDEKREQEEVESIMRKILAHRKKVETEGEKSSEPGGLVDIITGGRLRKLEDVNQTYYPGQEFKSTSQGIVFRAMAGNTLITSLKFLAYLKTGSSAMLSEAIHSLVDTGNQGILILGLQQASHQPDKKHQYGYGRAAYFWSLISALGIFWLGAGATVTHGVQTLLNPPKPDELLLTWELWTVLGMSFCIDGYVLQRCLSEIYSTKPKELSLYQHIKNIKDPFMLAVVLEDSAACTGVVIALAGIGASYLTGNPLWDSAASIGIGCLLGGVAISLIRMNQRFLLGQSVDPEIEQGIKALLLSRPSIDNVYAVQSQWVGPSTFSFKAEVDFDGTYLAAQLLEMYKPVFLDSDLESDLPVILAWYAEDVTRLVEKEVQEVEAEIRAKYPEAAFIELEPDSKDTDMRALSNIGTKSFRASEREAITRALAHLARSLDRSKISFPLRFLSRQLAFQWIKHSTLRCCIALSTAECAEDTNRAVKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X2L2</accession>
    <name>A0A6G0X2L2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_009197</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="VJMJ01000118">
        <property type="protein sequence ID" value="KAF0734024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X2L2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013938"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="293"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="46"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0734024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="333" mass="37749" checksum="40A6B99F77E0FAAF" modified="2020-08-12" version="1">MVATMTAERVILRANLEEQGALYFNNVDASRSSWSSNSRSRSNAPVVEQCMICLETTTDIIRNADKRRSTMEENRPTIDIDLYEEDIGRCAACPAIYCYPCFREYIRHKVINGEVRANQLVCPGACRLPLTKRMLRNNMSDATYQKYVDFLEMQQLVLQGARYCPRPECGQVLPSTTSKTAPTRRVYCPSCSKESCFKCGSDFHSIPICGDRTYRSWCRNHHVQACPNCTWAIEKDGGCKHMTCSRCSYEFCWYCHQDWQAHNKITCVPLAYYKSKHKYFGRTVPLRLVTKTVYAGVAAGVVVAGTGVALAALPPVLLWHCGVYVKDKILHRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X2U3</accession>
    <name>A0A6G0X2U3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_009093</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000117">
        <property type="protein sequence ID" value="KAF0734232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X2U3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020314"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01100">
        <property type="entry name" value="APPLE_Factor_XI_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000177">
        <property type="entry name" value="Apple"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33946">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33946:SF4">
        <property type="entry name" value="COAGULATION FACTOR XI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14295">
        <property type="entry name" value="PAN_4"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00223">
        <property type="entry name" value="APPLE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026084086" description="Apple domain-containing protein" evidence="4">
        <location>
            <begin position="17"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="5">
        <location>
            <begin position="315"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="22"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0734232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="455" mass="49495" checksum="12B0E2BCE7D1FFED" modified="2020-08-12" version="1">MKICLMLSMMVALAVGEVEKTSKMPSTAPPAPRPTTTQTPPPTRPFTPEPTPFLPPPLSCANCTPELPCYVGEPENGCRNLSKERCDTFGGNSKWCEFNSTTAPITPEVPLTPPPTTSEPVFTRGPPITCDQCTPEFPCSVDEPENGCQDWTKQRCETSGYSIWCEFNTTTAPPTLIPTPIPTPPSPPLTCSSCTPDRPCYVGEPYWSCLGWTKEQCNTGFSKWCEFTHTPTPIVTPYKCHSIQTDVDYYGFDLSQTSRKSADNCCGDCESTPGCKLFVWSDHNGGTCWLKHTKGKASKSPGAKSGVLIDTAPFCGNLEWNVDYPGNDIDSTNRASADECCVDCKANSECKLFVWTDFEGGTCWLKSAKGEKTTYYGARSIVVNDACGKPEFDVDYDGNDVGSTNRATPDACCADCKANKDCKLFVWTDFEGGTCWLKSAKGTPSKLHGAYAATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X385</accession>
    <name>A0A6G0X385_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_008968</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000116">
        <property type="protein sequence ID" value="KAF0734285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X385"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015302"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00257">
        <property type="entry name" value="beta-trefoil_FSCN-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008999">
        <property type="entry name" value="Actin-crosslinking"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50405">
        <property type="entry name" value="Actin-crosslinking proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026028576" description="Cytochrome P450" evidence="1">
        <location>
            <begin position="21"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0734285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="20600" checksum="C6449B639552E460" modified="2020-08-12" version="1">MVSIQTILLGAFALAQTVSAATCNFREGDVIALKADTGSYATRCRNCVHGSLPDSVNFQGPINSGTPYSYWTIVDAGDGKIALKGDLGYYLSQCNNCAYGASYPDQAFVHVADWKSAPWAQWTCEQADNGKIALKADSGKYLARCSGCVRSGPADVAFVHAAYWKDSPWAQFDVEYRDSTNQTTAAPATANN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X437</accession>
    <name>A0A6G0X437_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_008657</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000107">
        <property type="protein sequence ID" value="KAF0734699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X437"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0734699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="159" mass="17599" checksum="A942373081646967" modified="2020-08-12" version="1">MCRQISVDGNASFAWFDSSWKDQEYSTRQCCPRNITLGLSCLKHSLLSSFPKDKRAASSACDSVSCMQWPWVTDSHCGSLHNVGEKLLELVHTVARSSENGSQCCKSTLSIIHCSLTWIMRLHAVVISQSSALDADEVDTMARSLGVDPAVRHRTRPQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X4J6</accession>
    <name>A0A6G0X4J6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ae201684_008519</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the MICU1 family. MICU1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000103">
        <property type="protein sequence ID" value="KAF0734856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X4J6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010400"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990246">
        <property type="term" value="C:uniplex complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036444">
        <property type="term" value="P:calcium import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051560">
        <property type="term" value="P:mitochondrial calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039800">
        <property type="entry name" value="MICU1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12294:SF1">
        <property type="entry name" value="CALCIUM UPTAKE PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12294">
        <property type="entry name" value="EF HAND DOMAIN FAMILY A1,A2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026085403" description="EF-hand domain-containing protein" evidence="15">
        <location>
            <begin position="37"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="167"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="355"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="38"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF0734856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="411" mass="47198" checksum="89D588D19F3C20B9" modified="2020-08-12" version="1">MFGSWRAIHSRLKPHFSSQSALVGLIVVATAQTASSSNEELKDSVADKKKKEKKKTHWHTKQRHEESDQQSILLKESLKKYKEDLAAFDSVGARFDTFASAMTKEKDANGVRRKAMTFTDFLHSLVLPRFRISHPSRSLQYKCDFVGDADGLISYEECHLLYHLLEIPVEHFDVAFLMFDLDGNGTVDKAEFLEVLSSVLNNIKDKRLPEDSTDEVQVEASYHLLLHFFGKHGNKKITSKEFVAVIQSLKESLLRAEFDMYVHKENKKEDYITVHDFAVTLISCFDPKHLPAMLDRLQLLRASDERVTWREYLEFHSVIQNHLEGIKLAFELQPNHEITEDDFIKAAYIVSGVRLPAHIVSMAFRIFDIDGSGTLDENELLRVLSARNQTHHHSVKMWPPAKFWACVKNAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X4L9</accession>
    <name>A0A6G0X4L9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4145 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_008553</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000103">
        <property type="protein sequence ID" value="KAF0734891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X4L9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020336"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0734891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="113" mass="12576" checksum="632B3DC415D33E89" modified="2020-08-12" version="1">MGASSSKYIHSSNDYELVIKCSKELEYILEASFGAQGKGLHEKISAASSQLSPQLVKQMRFLATIRNRLIHERGFDRIPDRERFIQQFEQAANELNQLVQARGGTGGSSCAVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X4R9</accession>
    <name>A0A6G0X4R9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Saccharopine dehydrogenase NADP binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_008556</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000103">
        <property type="protein sequence ID" value="KAF0734894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X4R9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020333"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051276">
        <property type="entry name" value="Saccharopine_DH-like_oxidrdct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286:SF5">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="3">
        <location>
            <begin position="7"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0734894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="406" mass="44270" checksum="D02468EE1E830561" modified="2020-08-12" version="1">MAREFDIVVFGASGFTGQYVALCVAKRARELKTPLKWAIAGRSKVKLQDTAEWIQKQVEVEKIPIVIADVFDSPALEAMCKSTAILLNCTGPYAYFGEPVLKACIEVGTHHLDLAGEVQFILEMLVKHDKAAKAKDCIVVSAVGYDSLPTELSVLFAESQFPSNGSISTAEVFMGMDVQHGHATTYECIVLMSNPAHFKATNRLAKQLPAPAASSLLSKSWFGYDSRLGKAYFRFMGADMHLVGLSNPRVETVVYYYMNNLLFVVAFAIFGLLLATFGQFEYGRQLMIRYPRLFTAGAFSHEGPSPSQLNAGSFTTHCFAKGFQDKTKAGEGTPHDWQVQVRVDGPEPGYVATPILMVEAALCIWRGEVKARGVLSPGAAFRGTSLIKALETQGIAFTAVKSAQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X539</accession>
    <name>A0A6G0X539_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tubby C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_008440</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TUB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000102">
        <property type="protein sequence ID" value="KAF0734965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X539"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000175"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.90.10">
        <property type="entry name" value="Tubby Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000007">
        <property type="entry name" value="Tubby_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16517:SF7">
        <property type="entry name" value="PROTEIN KING TUBBY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16517">
        <property type="entry name" value="TUBBY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01167">
        <property type="entry name" value="Tub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01573">
        <property type="entry name" value="SUPERTUBBY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="Tubby C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubby C-terminal" evidence="3">
        <location>
            <begin position="274"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="148"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="175"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0734965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="525" mass="60297" checksum="2FBEF027960C8171" modified="2020-08-12" version="1">MFMAEDSFDDDRKGDRDLAKDVDDRMNISDKRREPHPNMLDDDDIEEIGGPTGSRSNVIQQQRDLHKKKMQERMSGGVVRTTGARQFSAPRSTDIDDNPSRFGRDDDFIDDRKSSNKKQSSNSRRFDDDDEEEDMSHRRPNPKKSGRQWREESPEDSRASRSKRDEPKSRRKGPDDDDDDDDDDDNSYERPSRCSDRSREKDNGRSSRRDQGGNDSWVEPKKKKASRDRSSSPDLSSEEEGNDEGVVSMIDDKKAPKNPVKKGKLDLTDMKAFLQRPVPKSYDVVECYIERNRTGANKLFPEYCLYMKDGDRFLLTAKKRPNNRTSNYLISMQRGDLARKGSDNFLGKLRANFIGTEFVIYDNGLNPKSADQHTLTVNPASIRQEMGIAVYAKNVLGHRGPRKMKVCVPRVREDGTRVVWRPVNKEEEMLNKCKEQDHTNLTYLINKPPRWNDQVGAYVLNFNGRVTMASVKNFQLVTPEDQETVILQFGRVGKELFTMDFRAPLCPFQAFAITLSSFDSKLACE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X5U7</accession>
    <name>A0A6G0X5U7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_008232</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000100">
        <property type="protein sequence ID" value="KAF0735320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X5U7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004036"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="5">
        <location>
            <begin position="269"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0735320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="369" mass="42185" checksum="A3560325F8567DBA" modified="2020-08-12" version="1">MREQRLPIPHNFLQLQRLEPADIERYRAFGHQVAREFVDLIDLEHGQIDWTFRSTTSTTTVYEGGNSAEPVYLARTEIHATLEEAIAVFQTTTVTATRKLQAKLQPLVLDKIRLYNVTTPTPESSNLYQSLNWCIVNTPFPRFILKRRDFCYLEHQEVLEIQGRRAYIRAMQSIDVAGVPSLESTFNVVRGDLIHCGFMFLETDRHGVLELVSLYDIRLNGSMKGALGSKIIERSVERHIRTLHDVEQVIRGHYLNHLRFLDPSTMPPLDSQSKCEICLRSFHRSRKAQCRHCAKIVCSRKCSAVWKVVKSGLEIDVCLCIGCSKQSHRPRLWSNSIFLTETTTAYLQSMTSCRDGSSHGRTTSCATRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X6H9</accession>
    <name>A0A6G0X6H9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_007912</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000094">
        <property type="protein sequence ID" value="KAF0735592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X6H9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003047"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF55">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 16 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1157"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="3">
        <location>
            <begin position="19"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="3">
        <location>
            <begin position="400"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="3">
        <location>
            <begin position="791"/>
            <end position="1053"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0735592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1197" mass="134505" checksum="112EA41C23F70E61" modified="2020-08-12" version="1">MEQQMLKKRSCSIDHLDPLDTMRLFVSATLFAAAASTKEEYLIFQDDFNSGFDLSVWKHDITLGGNGNREFQVYVNSRNNSYVKDGKLHLRATLTDEAYGRDSIEHGVMDLWGTSPYSSCSSPQFTGCRKEANGFDILPPVQSARVQTMESFSFKYGRVEVKTKLPQGDWLWPGIWMMAKDNRYGPWPSSGELDIMESRGNGPMYTDDKGDPIGNNRFSACFHFGPAWNKDGYPLAVNDTKALPNNRSYGNEFHTFGFYWDDEEMYAYVDTPDQIVTRVVDYGKKSFWDIGIEAKAWNASDSYNNFQDGPINAPFDQEMYLIMNVAVGGTSIAKGFLDSGYFPDDRGGKPWHTNDSYPAANFYHQKEKWFPSWTQGGVRSADMSAMQIDSVKVWGIRGLTTFTESKNPIQQYDASSIDTIHTTNNEHLIFQDTFDQPTLDLSKWQHEISMTGSSTASFMHMTTGENAYVKDGQLVLHATLNDLVYSLDNSTIDLWGDTPATQCTSNFNHGCLQTGTASTILPPVISAMLRTEKSFSFRYGRVELRAKLPRGQWLRPVFRLLPKYDSYGEWPQSGEIVLVDGTPSAFQSRVQYGPFNVSHGPNVISSLDDDDVHLFGLYWDEDELYTYVDSRDNVVTRIPKFGKRSLWDPQWGDNDTSPWTGQPDQAPFDQLFYLSVGLRVGGTDGFYPDDNTPGKPWNDTAIDHKKTFLAAKDSWYPTWAGQGASLEIQDISVWATSEASRWAYHGAFELSPEKEANKLLFSDDFTTLEMRHWKPEITMRPHGEFQVYVNHRQTGYVRNHTLVLQPTLSEDIIGKWSLTQGYIDMWGTDLPSKCTAAAAGGCGHLSTPWDMSPPIHSASFRTAETFTWRYGRLEVKATLPRGDWLLPRIQLVPLTAAGWFDVVVAHGNTGSSKIYTGSCNSSVSCDVRENDIEAQSTHTYGIVWNESTTIVYLDSPATVLWQGETPDSLKHEVYLVVQAAVGGVSELPHYTFDKYSGKPWDTTSKAQPHTQFYAAKSQWWPSWANRSLDDGHTVSIDSALKIHSVQVWSVPGTQWRKHRLVGDPDVTDAVVQVKPSSSTTNPASIDNQHDGIGLKDAFTSSENQVAVDLSDQNTSHYNALWFAVVTDDGVGLKDAFTSTENQVPVDLSDQNTSHYNALWFAVVTATSLMTLLTLFILIKVGAKMLRRRDYTTIPDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X6Q9</accession>
    <name>A0A6G0X6Q9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_007927</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000094">
        <property type="protein sequence ID" value="KAF0735608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X6Q9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012718"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026225567" description="Secreted protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0735608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="20406" checksum="F9876B2803784846" modified="2020-08-12" version="1">MKTSFAVLALAAVVAADDKDACTIAIGKAVTPYFNNTAAVACAKVLSGTNMANVFLAGASSADQTKLLASADCNTWYTGLAAAVKAINPPCTYYVNDQPVYKTDAFNWTFAEFLQQNNAASQNATTTTPKVTTKAPPATNATNQTTTTAPSSIATPEPSSASPSVSSATSTTAAPTTTPKSSAASSAVAVTALAAALYMANN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X6X3</accession>
    <name>A0A6G0X6X3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bulb-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_007774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000093">
        <property type="protein sequence ID" value="KAF0735769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X6X3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014495"/>
    <dbReference type="OrthoDB" id="61382at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.90.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.90.10.10">
        <property type="entry name" value="Bulb-type lectin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001480">
        <property type="entry name" value="Bulb-type_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036426">
        <property type="entry name" value="Bulb-type_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51110">
        <property type="entry name" value="alpha-D-mannose-specific plant lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50927">
        <property type="entry name" value="BULB_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bulb-type lectin" evidence="1">
        <location>
            <begin position="27"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0735769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="158" mass="17571" checksum="DE679BEF31F866B5" modified="2020-08-12" version="1">MASVGAFEAHCEICDLDQGQFFVSNIEQHDRLEGFVPSRSAITTDSKALRIQMQPDGNFVLVDLINNKPIWATMKFCRSNEAIFAIMQKDGNLVVYCRKRGDRPIWASQTSLQGTGPYCAALSDDPTRFGLSVYDATCKLLWRTDAKPPAIPDLPKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X7H9</accession>
    <name>A0A6G0X7H9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_007848</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000093">
        <property type="protein sequence ID" value="KAF0735844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X7H9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007205"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="109"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0735844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="406" mass="44237" checksum="0C2A07CD2CBBEAF7" modified="2020-08-12" version="1">MFSWGNATNDKPSDLWTAAKDGNIQKINEIILDVQSTINVIENDATPLWIASKHGHANIVQLFLEIPNVDASWANADGESALHVAAKEGHVEIVRLLSAHVDINQANEDGATPLYLASEFGHANAVKLLLNVGANISLSNLNGASAVHIASERGHLSIVQTLLPHSNLPLIDNDGWTPLHSAAYAGQLTVVEWLVATNAFDLQATTHGGDTAFVLASEEGHDHVASVLSSQSNPEIRQLLPSFWLLERVSGHAYTRGTRLSTKLMQLFSHSGHEVTIEWTGEARDAIVGLVLPLFRASVALVKAVALLDEYNIRWENYLRLDGSKFPQLHLAVTAMTWQHGNLSEKLKVESELEPLVQALESGQLLSSEAEAIGAQIQTIWESHHASEETQRLVAQLRAAIKTRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X833</accession>
    <name>A0A6G0X833_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_007250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X833"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001174"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020046"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF57">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="2">
        <location>
            <begin position="102"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0736228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="480" mass="55042" checksum="A6ECDC3307A1995E" modified="2020-08-12" version="1">MNCNSDSQPTSQTVRGRPVIRNAPKKLAKKFKNVHVTYKMKQNVIDTFDEVGMAATLDRHFSNRSGSDREVARKKVYKWLKQRDLIEQKASNAKTAHHKCARDIGMGTSLPRDAEEQLARWVSSMRKDGVPVTPQMLHMMALETATDLGLDEHPFKASWHWMKAFKKRFGLALRLRTRIGQESQTDGEAALSAFSRRVQEIVETEGIETIFNADQTAVNYEYLPTKTIHQSGDTTVWIKCGGKTKERAKAMLLADSSGQSKHKDTVHDNWIHRHGFGKHVWKQVEPLQGQFNCQVYGNPTAWWNSSICVEFLKYHFEHRPDRMTKKILLLWDDFSGHFTDEVIACANELNIVLEKVPLRFTWICQPADVAWIRPMKTRLRQHWIDLIRQQVRSNKAQGSSFKLIPPSRSTILQWITKVWDDLPRTTILNGFGKCKLIHHVADHDAVEPAVLDEETLSHLFAGCAVDTTIDPMDDIDTHED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X8Y2</accession>
    <name>A0A6G0X8Y2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha 1,4-glycosyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_007431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X8Y2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004026"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF1">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0736412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="37515" checksum="438A465DED8E1338" modified="2020-08-12" version="1">MHLLPAFNLQHHNAHDAKTRPSHGFLMKCAVCFLLVFVGYNISNVSSIDTAREALARSAQEETIVRDDQPPVCRVQFVFTGSKYNYAQFPTLQSWIRYTDSKCVIEFILANHPFMTQLTPAHARMFYESDYLPILQADMLKMFAVYYLGGLAVDLDVEALKPFPSQWIGPDTALATCDVVLGIERDCYDNNCLSSWRMRRKGQIQNWAMYARKPRSTFFGELLDFTVDRYERFHVPHGPNATVEVQEIAGSGVITDFVQLFGNFSKPLHLSETSPQGPSLVSDKTSVLRIKKNGEEVCIVGSRYTGFQCSQWPECILHHHYEGSWKTPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XAV6</accession>
    <name>A0A6G0XAV6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycine zipper domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_006914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000085">
        <property type="protein sequence ID" value="KAF0737110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XAV6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008262"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0737110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="16787" checksum="A02A479F17B36847" modified="2020-08-12" version="1">MDRVPAQVRQVNRRLPLKYERQGKRHGEYVGETVGSAVGLGAGIAASAAIGTVTGGNLGTKAGRSGISRLGLMVGGTYGAKYGAKIGAFAGRQMDKLTKGGKQVKAEAANAKKKKEEENKLPKGPILFTPAGYKPLTRTGSSPAIMQRGPLVVKRKLLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XB26</accession>
    <name>A0A6G0XB26_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Anoctamin transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_006463</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XB26"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015818"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF73">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="453"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="481"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="555"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="637"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="676"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="741"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="796"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="835"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="7">
        <location>
            <begin position="432"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="904"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="911"/>
            <end position="947"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0737290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="954" mass="106452" checksum="0D31B00FBC55FA3D" modified="2020-08-12" version="1">MQPPRAVEAAQPPRPSLAEPFIDASDVTPGQVELQDVPLHVESDSSDVDLVLLFNLKSGGEVKHAERFTKEKFLKRMLGLRETRKGPAVNELKTVLKTPKCFVDDAGVPFKTNNGSTDSVDNKMACLAAEYKDFVGSDGNATEAAFCQLVARAVAKRLQLTCGLTVKMFKSKRGNLIIMTVKADEGDLKTEAARIEYRLQTSNKPFDAIHAAKLRAIVADEGNDASVIDASKDHLQAARCSLVPHVLGDAGEKTGAQLDQPEMDPLLLSLGKTCQPTLATALAKWGHNEVADGQFPPPRASSSFFAFLTSFCVASAPRSLWKRFVSSLIYISRDPSTYFSLYTPYQQDAMFQPYFRWYPASAKGTKEETLFRPVDRIRLTMSIVNRHLNLDVLRHYGLLNDVFALHDPTTLEMLKKEWATKVTLSAQPIGAIRDYFGEKIALYFAWLELYTKLLVLPAAFGIAIFVLDVVTTVVPSRDLKIAFAVAIVIWSTMFTELWKRKSAIYNVIWGTDHSDIQSTPRTQFVGVQRLHPVDNTPQMWIKSASKHKCKVRASFVVVFVMVLIVIVALVGLFYLKYLSARLTSPSAKQWASVGVSALNSIQIALLNKFYNGVAHWLNNWENHRTDMEHENHLINKVFLFQFCNSFASFFYIAYVKHYVNDPCVDDNCLAELRLQLIILFGLQIVTGNLIEVLMPMMQRSLALYSDKKKHHDDAQFSQEELQSMLAPYEGSDAFQDYNEMVIQYGFVTLFVVAFPLTPAMALINNMIEIHSDAFKLCSAHRRPFPHRAASIGSWDFFLNIINTLAVVTNIAILLFTHDPNDSVTTTATSSTTKWVTFVIAEQVCLVMKFVVAFVIPDEPQELTELKARHKDIEANVFLGQNATEPPSTELSEKPEKLHLVIYDSCDQASMPRPPSPVLPRPPPADMAAMPPPAPQAPPQVPELPAPAPQVHTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XBJ7</accession>
    <name>A0A6G0XBJ7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_006504</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XBJ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000986"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="20"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0737335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="320" mass="36924" checksum="C757845FB5B6846F" modified="2020-08-12" version="1">MNKSTLPPEPFASSRVNFLHFIDVMVCATDEHAKGYRKHVNYMIQVNEVGKGHWIVSRRYTQFRLLWRTVLKLYRASTIKETRHNKNHMAQLKSLSTFAFPKKTMKLFFVGIDSTSHHVVRDRIVRFDAYLQELIHFLREFQWGEENRQQNAISSKNATKLCWLIDAFLSVPKNFRNADGECDYLHSHPACRNQDNVHCRDLNLVLHTPTHSMSRRSVSRRHSAPPTKKHKGPRTNSHISQSGGNEAFEHILLPTKAMQLPVVPLRKQKSNSDPVRPSVWLESMRPGASLVECPFSMSFDHDFSTPMLGDSPRDTIILGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XDP3</accession>
    <name>A0A6G0XDP3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_005784</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ZNF593/BUD20 C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000076">
        <property type="protein sequence ID" value="KAF0738347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XDP3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015382"/>
    <dbReference type="OrthoDB" id="24683at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000299">
        <property type="entry name" value="Zinc finger protein 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051879">
        <property type="entry name" value="C2H2-ZF_Maturation_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46095">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46095:SF1">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0738347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="123" mass="13796" checksum="25F12006A3508472" modified="2020-08-12" version="1">MAGPTTGKKRAHAKKKGYKRSHATCNRARDIDQIQDDLKKESETGAKITFEMDEDLPGLGQYYCTPCARHFITANARDVHIASKVHKRRMKDVAQEQYSQKEAERAAGKSIEVYTPVHAAVHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XE21</accession>
    <name>A0A6G0XE21_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EIPR1-like beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_005868</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat EIPR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000077">
        <property type="protein sequence ID" value="KAF0738311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XE21"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001162"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059104">
        <property type="entry name" value="Beta-prop_EIPR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040323">
        <property type="entry name" value="EIPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14205:SF15">
        <property type="entry name" value="EARP AND GARP COMPLEX-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14205">
        <property type="entry name" value="WD-REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23609">
        <property type="entry name" value="Beta-prop_EIPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="EIPR1-like beta-propeller" evidence="5">
        <location>
            <begin position="11"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="168"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="211"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0738311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="362" mass="40394" checksum="20ADC56FC7F65F8E" modified="2020-08-12" version="1">MFGGTALTHEAKRIARYVDAVYGESDQQRFVLGTCTPSVKKQNQLQLLDANLSLLRTYDHDAPIDHFAMCPLAQQHDKIVTASISQQQESSFAVWKMQHLEDTSNGSSSDNASLELLNRVTCPTRVIRSIWNPTEETNGAVLATLNTSSLSTWTLVDGAGKEASKFTLVGDGKQLSAIAWDPHHRQQISVTVDESIQTWDIRSNKVAYKIDKAHLECARDIDYNPNKPYYIASGGNDGKMKFWDVRKSSHAILSIQSHSHWAWCVKYNRFHDQLVLSSGSDSVVNLWRISSISSAPILEMDEGGESGIDIGDAKIKSFEEHEDSVYSVAWGSVDSWVFVSVSYDGRVVLNHVPSTEKYRILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XES9</accession>
    <name>A0A6G0XES9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Spore protein YkvP/CgeB glycosyl transferase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_005353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000070">
        <property type="protein sequence ID" value="KAF0738734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XES9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000296"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055259">
        <property type="entry name" value="YkvP/CgeB_Glyco_trans-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13524">
        <property type="entry name" value="Glyco_trans_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spore protein YkvP/CgeB glycosyl transferase-like" evidence="1">
        <location>
            <begin position="157"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0738734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="703" mass="78356" checksum="408DA2273352CABF" modified="2020-08-12" version="1">MTCRGFADAFERQGHLVRIMYPGNYSAITDHLWDIVFIEGWFPAITAFIHEVRRVTSDYVKVYFFCLDPDFPGLDIIQDLDVDAFFTNSHEALDILQHHAHYAEFMQLAATPSQISSTSLAPKPSVGLNASIVYVGSVVGIETKRDLPTMLHEAIPFGLVIYGHAWNLYPEFAPYWRGVLPPEDLLDVYASAKVILGATMAGQRSSGMINNRVFEVLAAGSILISDHFDALERLFGDRILYYTKPGDIARHMATLAAFPHTPHDLRAFINDHHTYEHRVEQILAVHLTKLPMLQLDSRPNSPLFAVVVDHSFLDTDFLASMYVQDALIPALESLRSTYCVVFVSLADAAQATLKHGDFVLFVSCWACPLDIDARKTFPEVSVYGKGLYLLRTPMEPLPSSAADFYDVLFATGMQDEASLAHLRSHRRHAFGLDLQRYEPHAKPSGVPCEWMAVGDWGADEQRLLRITGFPRQPNATYVVVLAEKNHQDHANSIAFLESLGYRVFFATSPSQIVSRLREFQCKATFLPAVDVIGSGGDWLVSIAANMGLTLHVVDDSIRWGAVYSSKPRWDLTYLTDAFRQGMAQTLCFGRANSTVRMVSPRDGAFVGRVFTVEFDTSLLDVPRDGNVCLVINNDTYGCVMHPDLKFTVAWSMSGTAGSSLSLQLVLTSNIYGNYFASAPSIQVYYAPDLPEEPRPARAYHISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XF70</accession>
    <name>A0A6G0XF70_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_005460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000070">
        <property type="protein sequence ID" value="KAF0738849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XF70"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013225"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052732">
        <property type="entry name" value="Cell-binding_unc_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43883:SF1">
        <property type="entry name" value="GLUCONOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43883">
        <property type="entry name" value="SLR0207 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13671">
        <property type="entry name" value="AAA_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0738849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="607" mass="68597" checksum="4C4425A989FD5B34" modified="2020-08-12" version="1">MASAALRKKKLLVSATGEEICRGLVHPEAYLEDPSTVDDEQLDPDTDPIELIQTHMSMVFLRRDVVYKVKKNVDFGFADFSSVQKRMEACLAETQLNQRLAPHVYLGVVPIYKLDDTLRISTYDVWTHERDKDPTYFANDKLGEIVDWAVKMRRLPNENTCLHLLTVGHLDAALLQLVASKIAAFHTAARKNSAIDEFGKPAVIKQNMDENFTQTATHIDAGLVHGYVYNRVKSLSERWFADLLDVFEHRVQHKYISDTHGDLRLEHVYFLPKHANVSLPPGTAPSMATYALPTTLSTETVDVVVLDCIEFNERFRYSDPLSDAAFFSMDLWRLGRPDLATVFNTAYLERSKQTSKANVELLRFYAAYRSVVRAKVSGFQALDPLIQDKTRAFARSRCHWLIAFSLLAPPAERPCLTLVAGLPGSGKSTVAEALVQADERWVWVRSDVVRKELAGVKATEPSPEAAMADVYSTAFTQKTYMECWAQAQEALQRGRRVLVDATFREQAFRRLFLEGAKKEGAMACVVVCECNREIIKGRMTKRETATEHVSDANWQVFEKVESSWTPFEAATGLYAVTPQDIFTVNTDKQIELSLQRVHGFLRKVGME</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XFQ9</accession>
    <name>A0A6G0XFQ9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_005309</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the complex I NDUFS4 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000068">
        <property type="protein sequence ID" value="KAF0738938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XFQ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016050"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.190">
        <property type="entry name" value="atu1810 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006885">
        <property type="entry name" value="NADH_UbQ_FeS_4_mit-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038532">
        <property type="entry name" value="NDUFS4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12219:SF8">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12219">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04800">
        <property type="entry name" value="NDUS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0738938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="226" mass="25366" checksum="AE6514D1CBAFFDB1" modified="2020-08-12" version="1">MMIRAVARGRPAVAKMCRSFSAAPEVEDDTALMQQLKEEVIARRFSVMPPHASDDENPSLNLQPIEHPKECAIVNGVSEWSKGRRAIIYVPARNQMQSGRANTHHWEIRFGARKTWQNPLMGWTSGADAMADLVLKFDTKESALSYAERQGWEADVYEPAEAEDFEGQIAYSHNFLPLAVENELKRYGKNAAPRFKHPTGGHSHWVKTLKYHGNGEVAQHGGEAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XG11</accession>
    <name>A0A6G0XG11_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Photolyase/cryptochrome alpha/beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_005112</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="4">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA photolyase class-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000066">
        <property type="protein sequence ID" value="KAF0739187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XG11"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018822"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.579.10">
        <property type="entry name" value="DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="CRYPTOCHROME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455:SF9">
        <property type="entry name" value="CRYPTOCHROME CIRCADIAN CLOCK 5 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="Cryptochrome/photolyase FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="2 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="7">
        <location>
            <begin position="7"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="487"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="493"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="386"/>
            <end position="388"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="5">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="5">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="5">
        <location>
            <position position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0739187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="531" mass="60569" checksum="A892839D4E7655E5" modified="2020-08-12" version="1">MPSNAAAVSMVWFRKGLRLHDNRALLEAIRNASFLIPLVVIDPFLVNPTRCGVRPLQFFLECLQDLDRSLREKNSRLVVLTGDPVDIIPRYAQKWNVSKIFCETDTGRYGTVRDANVATALAARSIQLVSYSGHTLYPIHDVRLAYGNRYPQRYEEFRQRVANIVIDDPRPSPEVLPPLPSVLPDSDASIPTLKGLGFDEELKPTALVGGETYALERLVKVMGDEDNIRMYSKQDTSPLDFEPASGTCLSPYIARGCLSVRLVRSHILKILSKGREHTEPPRSLLGQLLWREFHYAASYLTPNIYEMDGNPMCKPIEWRKEPQELFQAWADGRTGYPFIDAAMIQLKQEGWIHNAARNAVACFLTRGDLWIDWRLGRDLFEKYLIDSDTALNNGGWLWQSGSAYLPNHFTPQNPITYAKKFNPDDGAYVRRYIPALKNMPTQFIYEPWKAPRHVQRKAGCIIGQDYPERIVIHEVESRVLTERMAAYHQKAKSSQSSSRSHGQNGQRRQHITSLVGKKYTKRIENVQLNTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XH00</accession>
    <name>A0A6G0XH00_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_004762</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acid sphingomyelinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000063">
        <property type="protein sequence ID" value="KAF0739582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XH00"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006095"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045473">
        <property type="entry name" value="ASM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF57">
        <property type="entry name" value="METALLOPHOS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19272">
        <property type="entry name" value="ASMase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026346718" evidence="7">
        <location>
            <begin position="23"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="8">
        <location>
            <begin position="24"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Sphingomyelin phosphodiesterase C-terminal" evidence="9">
        <location>
            <begin position="288"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF19272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0739582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="465" mass="52625" checksum="B2F393322FEAB270" modified="2020-08-12" version="1">MLLPSLVGWTAVAFLTAASAQAKTILHISDVHLNITLDQMHYGFDSSPRLLDSALSYARSVLRNPDLLLYTGDAVAHTKHNESVLATSVRAGIDMLESYFQVKNVTAILGNADCLHDYEFYITDPKNGTNPTIGMVDEPWKKSLTRSQFNQFDTRGYLLYQIEPKLILITLNTVPYSIKHSPDTKHLDDPFDQFVWLRATLDETRRNGSFAYITGHIPPIIDSYKGESQWNLKYILSYKAIVQDFPDIIKAQLFGHVHSIEYRVPVENLDGLLGVPLFASGAISPFFGNNPSFTIWEYDADTYDLTDFSVFATNFSVAGSDVLDWKKIFTATTLYNLSSISSKSLRELTQRMKADDTLLHEYYRHSKADTRRLTPCDTTDCLDRVLCAQTWFESEEEYQQCVDDRGLERAGAPDLVETVPRVSWFWALLVSAVAAALLSGLIVFLHRVLKRSTYMSLRTPMHFVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XH97</accession>
    <name>A0A6G0XH97_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_004701</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histone deacetylase family. HD type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2"/>
    <dbReference type="EMBL" id="VJMJ01000063">
        <property type="protein sequence ID" value="KAF0739519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XH97"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018960"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018961"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF10">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="6">
        <location>
            <begin position="4"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="625"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="659"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0739519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1056" mass="118963" checksum="72F0202FA31895B1" modified="2020-08-12" version="1">MMTFSLLQYSGILQHLSVIAPEKASTEDLERFHTRKYIEALQAEEGLPTTEAMTFGLVDDAYSFPGMFEYCHYVAGASLTAAKLLCSQTVDVAINWGGGRHHAKKDQASGFCYVNDIVLAVDYLLRQHLQAKVLVIDIDIHHGDGVEEAFYFSSRVFTLSFHKLARGFFPGTGASSSTGQGAGRYRNLNVPLDDGITDEQFLEVFELIVEPVVDAFQPTYIVMTCGVDTLSTDPLGTFNLTSTGVTWCVEVVREFQLPLLLLGGGGYCEADAARCFAAVTAALVDQELPMQVPDHDFLPQYGPHFSTAIKAVKSREEDKRHLCIIERLLSSFKVSHSMTFQIATSLLEQVDLDVFIGVLPSLDKVRTHPNKLDIPILWSVSEADIADMEYLEHADDLRSRGHLWASYAALSNASDCRGDCKTFFCIGRSYILAKMYQELGMAQTACKHVQEVLRISPLHDGAIILSNTVCPKSFVSKRVNDYESIQKLLDSTTIVKARTWEFLEENLYWAGKEPRCLPLLLNIGAMFHMRGLHGYALKYYTEVLMIHPAHALTLSNVNSLWSSSTIPIFFHDGITSFYSNNVLLPLAPEALTQCRDKTTEALQHGDRYRALAKLMIAAAYGPIDPTLYNNLGVVQYQLGNFEAAIAAFERASLLQPLLAQPLNNIATVLQTQSKNEVALGYFDRALRVDPYDATARYNLGNTLLQMDRVDDTILFYWDTFDLKLFLNWKKNDLLHLVTLESISSLVGVLLLELKHSNTTCIQEVLKTQFQVPFQSLTSLGSLLERTLHYDRSWNVLALALHSKGNVRNIQDTYNLVHKACASQNDHVKREDKPFVQLIVQYFIATSKERQDEIDAALRLNIGNPHIARIHVLLEKTLNTIDQFHNYSKQLHGYSKLKIVIVNKRLTFRTAFGYISEEAHNQNNTIWAICNADIYFDESLSYVRSRPPLSNQVIALTRWQYGAKTHEVSFWPRIDSQDAWLLTSDSLPEQVLVQSDYPLGYLRSDTRLVSILTTFNVSVINWGFHVKAIHLHESTARSYTQQNTAWGDDAYLHLSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XHL4</accession>
    <name>A0A6G0XHL4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">leucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ae201684_004884</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="2"/>
    <dbReference type="EMBL" id="VJMJ01000063">
        <property type="protein sequence ID" value="KAF0739716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XHL4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018179"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07959">
        <property type="entry name" value="Anticodon_Ia_Leu_AEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000001">
        <property type="entry name" value="Leucine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004493">
        <property type="entry name" value="Leu-tRNA-synth_Ia_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055416">
        <property type="entry name" value="RBD_LARS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00395">
        <property type="entry name" value="leuS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794:SF1">
        <property type="entry name" value="LEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794">
        <property type="entry name" value="LEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24810">
        <property type="entry name" value="RBD_LARS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="11">
        <location>
            <begin position="31"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="11">
        <location>
            <begin position="195"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="12">
        <location>
            <begin position="800"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine--tRNA ligase RagD-binding" evidence="13">
        <location>
            <begin position="953"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="240"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF24810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF0739716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1084" mass="122557" checksum="F090DA49BBAAC73D" modified="2020-08-12" version="1">MAQVTAQLGNMEIEEKKFGRRNHLVEIEKEVQRRWDEAKIFEGSVEEGKPKFMATFPFPYMNGMLHIGHGFTITKAEFATRYHRLKGENALFPFGFHCTGMPIQAAANRLKAELEEFGFPPQFPVEEVAPPPAPAVAAPGTDNKAKGKKSKLVAKTGGVARQYDILTKMIDDKELIPKFADPMFWLQYFPPFGEDHLRRFGLATDWRRSFITTDVNPFFDAFVRWQLNTLKERGRITRGKRPTVYSPMDKQSCADHDRASGEGSNPQEYTIIKLAVKTPLPERLSSLSGYNVYLAPATLRPETMYGQTNCFVLPDGDYGAYRINETDVFLISRRSALNLAYQDYSRKWGEVECLLELKGWDLLGLPLQAPNAVYDTVYTLPLLTISMGKGTGVVTSVPSDAPDDYAALRDLKQKAAMREKYNLTDEMVLPFEVVPIIDIPGYGSTSAVAVCDELKIASQNDKEKLAKAKDLVYLKGFYEGVLLVGSQAGKKVCDAKAAVRKELLEAGHAIPYWEPESTVMSRSGDECVVAQLDQWYMLYGVEDWKARVSAHIENPETFQTYNPVALGEYRSTLEWFKEWAPCRQFGLGTKLPWDTDFVVESLSDSTIYMAYYTIAHHLQGSVDGSKPGPHGITADDLTKEVFDYIYLKGPEPKASKISLSVWQELRKEFEYWYPMDLRVSGKDLIRNHLTMSLYNHAEIWADDPSKWPRSFFTNGHVQVDAEKMSKSKGNFLTLEFCFTEYGADATRFACADAGDSMDDANFSRDTANMAILRLTTEEEWIKKTLEELPHLRTGELNFNDKVFHAQMDDIIVRTAAHFDAMQWRDGFQTCFFELQIARDSYRDICTRGEFGLHKDVILRFIEAQTIMLAPICPHICEHFWTLLGKPGFVSNALWPAVTGPTDFTLLRASDFLAKSLKHFRDAVLKGDQAKGKKKPAAPAAEAKKPTHAHIYLANQFPAWQQSVLKFMATVFDPSTKSFPADFMAKLKLLLNDHEDLKKMTKNVMQFASFVKADAELRGQEAIELSMPYDQKAVLESNKLYLLKTLELQEILFFYVDGGVSIEGSDPKKIEVAAPGKPTIYLYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XIP5</accession>
    <name>A0A6G0XIP5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">KNTC1 first ARM-repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_004389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000054">
        <property type="protein sequence ID" value="KAF0740152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003790"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070939">
        <property type="term" value="C:Dsl1/NZR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055403">
        <property type="entry name" value="ARM_KNTC1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15922:SF2">
        <property type="entry name" value="NBAS SUBUNIT OF NRZ TETHERING COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15922">
        <property type="entry name" value="NEUROBLASTOMA-AMPLIFIED SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24520">
        <property type="entry name" value="ARM_KNTC1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KNTC1 first ARM-repeats" evidence="1">
        <location>
            <begin position="361"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0740152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1975" mass="219705" checksum="70FA0C21B0C40E1B" modified="2020-08-12" version="1">MLDAKQVAQINLPSDVPGDTVQLMASNVEEEGMLSFLVKTDKACLLVQDKTLLPLSCDGPSSSLSSDGMVICGWTSGKTLNVYYGGEMIVSRLLDLPSSVWQSYVIKSRVASASLYEFILIVITIDGSIHRVRIQAAHETIQLLAEVSQSHPTLTTSALHGDLLVLAGGIRSSDRGMEQGSTLSLWNLTDTSAELLHYSTVLSQVSAEPTEQSSWWSSMLSPEQLYPGTIQELSISPGGAYVALLDKSGHISIRQVDTCATLVDWTLVHSVKATSLGWFHPNQLVVASSAANTPIVCEIIDDKLSIPELEDSSHPRDDDSTLSSNVLATPTNGVFFHLRGSNSNLEIVMFREVPVDIVYSKLLSQHRFDEALALATAHNDKLDVDVVHKAVWLHHVGVGTATEALDSLIADHLTHVHDKTWIIETAKRTILDSPGTCSRLWTFALSKDDDAALRQLLDRLETFVSLIQGNKAAEGLSSEFFELSAFEEFLAMPWLDIALGFAHEGRVRDLSILFDRHGYHLLPHKCTILSALPASLPPRDFQHLLPCIPPSLQDDSDLLYYVLDAISDGFVAATLRDTPDVTPQVIHEYNAQPSIEQRRKTICDWFVARSYEMDSMFGLLEDAQTLIQLSRRCVGDAHGHEELAKLYREFEELHLFVYDFEVTPMWTIQAWQHANSVKPSHKLELVIESNQSKAQVLELLRRDMIRQEELAAAITALDLTNFDAFAWAADILAASSPISTERYIRDNRILVETALFCCFGFDLADTDRPQYFIECAWAIFQTLPKVLPDEKLQTEADALEHYMTAMEILASYNCFQSPVSLRQRAGESTFFTLLVDQCCATVTSEAQYEKLLDDMLLVRDHAFPAAITTDDAIASVCQCLLAHASSPSLILRQLCPSPTILLEAAKAHFHSATSTSSPSIALALTYLAWIEDTVECNYASLLYATQWLEQCKGEPIAPATIIALSNADRLAYVQDLLVNRSQHCINHLDQLAEVAQWLDLTPKLPWMQVWAAYAYLQSRHVDRAIALTISILTQASIQDDGFSAQLASLTLDLVSLSGHYNARHQLCSTALFSIQDNGTSMVLLDWAKKLDAIVQSLVVLQLSEDEVAAEKDSQVSDYVWFSEQLVVHQEVVSSQPDLLCKSLIASIHLDLAFEFHLPTATTDVVRSGPSLLSRLGQLAEIYLDRMDIAMAKGYLCRLSATQAFDIWSTACARAEPANQVVLAQHAQLYFKDDATKVQHFASLQVSSKQEADLDLLQQILPSFDRSRFDVDHIYRYDMLVQLMATQRWQEAANICAKFQMNLWELHVQFLEMLLTRPGVESREEELKKAQLPLPTEGMSLLQHAMTQPSALSQRFLKSTAQRLDPFDSIAWEYLWWVCLECFKRDPNAVDLPAERLKLYCACANKLRKSDIRVHLPHFCSSDLSLVVASVVPILSGATIRVMALMLKKLHGLPPSTIVFIHLDMVLANHVDADKAYETALPFLSTLSTEHLVIVVAKLLSPHAHHEVHGYTIQAPARYAPRLSSAKRVEVVLDIYHMAQARQAPPTDVTFLERQVLWSQLAALIAQAKLQPPVDTFPSPSVLPPFDAQIAAWCCQPVSLAFCRSLLQLTSALDSGKDHQPLFERHIGAMLEAHVLTLTAGDELVKPSPHPLYRYLAAKWAQDQAPPVELRLIPETVVVEPLEGIFCAAVLKWLEDVEPSPSTVVLLSWMNALVPPSVSNAFGSTHASASIVSMLYELDGDGEWKSLQTQVTTDFDNVWNAALLRIADTPAANEGLANVLLKWESHQEQSSSNVSWATELSRVVAHRLELEWEEETNPLPLFSAALWHQLWSRTQWSEEGLNNLLRSNPSAYASLTEEIVQQFVTEGYTIVALLSPFESIHAALMPDAFNFHELTPSHLELLIVRFPLDVLLPIVPWDRMVQVCIHHEAKGGPNALASVLYLVVGFLAEDNLAMTSRILCQVANVHPMHQISGEQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJ39</accession>
    <name>A0A6G0XJ39_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_004112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000052">
        <property type="protein sequence ID" value="KAF0740375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJ39"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019445"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0740375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="161" mass="17089" checksum="EC051D2BED92C3ED" modified="2020-08-12" version="1">MADLTEFTTYPANRVVLARGLVLLSTIISFFCCTAVTGASAGDYAFIANFMAIGYTLLHAYFVTYQKNVSFAHMTQLIVDGVLAILLLAGAIAVIAYPWYKIPAAGTVTFIFMFVATLGQVLVIVFQIMGADRTGNQLAATPQDAYVAPTTDVNTGAAAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJ54</accession>
    <name>A0A6G0XJ54_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane protein 14C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_004316</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000053">
        <property type="protein sequence ID" value="KAF0740317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJ54"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014141"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1740">
        <property type="entry name" value="Transmembrane protein 14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005349">
        <property type="entry name" value="TMEM14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044890">
        <property type="entry name" value="TMEM14_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12668:SF43">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12668">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 14, 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03647">
        <property type="entry name" value="Tmemb_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0740317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="119" mass="12384" checksum="40DE9FD2882E037C" modified="2020-08-12" version="1">MYDFCLTLPYGAGIAIGGIVGYVNSGSSASLTAGVGAGSLLLLLGYASYQEYLSSPVVSKKWSGLSLIISAALSVVMGLRYQKTNNFLPAGLIAGTSVGMSLFYVSILLKSNKANYKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJK8</accession>
    <name>A0A6G0XJK8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_004212</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000052">
        <property type="protein sequence ID" value="KAF0740478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJK8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010446"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="4">
        <location>
            <begin position="33"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="592"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="680"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1001"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="680"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1001"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1030"/>
            <end position="1046"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0740478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1085" mass="125032" checksum="A85AC36A3628401C" modified="2020-08-12" version="1">MLPTFTRHDGFPLPKDYSAEAFKSGQTLPARASDVFVCAYPDCGTAWVLGLVNSLLRDGEVQPADAVDAASIPHLERHGRDACERMTANDSIRLFRTHLPYNMTPQHPDAKYIVVGRNPKDTSVSFYHRHVQDEATWDNCFERFLEGDVEFGNFFAFFVPWFERHVEDNVLFLTYEYLINEPRDGLLRIARFLGNDLEDRLLDHDSGLLHAILQAVQTEKGRVKIGEWRNVYSPEQSKRMDERFQEMTKGTGAEHMWSDVIAKSPSIARSISLHEPMSMDRVALEEELARQLAEVDAYDDDIEDTTHPELTSTPFHRLDLSALLHDVRCTPLTSQAYQEYAAALVECDATLIASMEATLADVQTCLLPWSCDHPVVVSVERTAMETPEVVSKPAHDTSEATETTFCVDHCPPCCIGPCKTHCPPDCIVFLALSDAKTKADAILAAEEAAFMQLALASVEKIAADVRSQPKRESLNSAAECSAVVPAVDPMATSDPEAEQKARERLEQIERSQQALEAQERALAELVAAEERAQRERELARQAEIVADERRRQDEAQRLAGEARKQREIAQQAIDAMEMAAEERQMRAWLRAKEESNAKDARQAMERAERQRLQVEASMRRQREVEIRRREEEREREELARMETVEREQRAIAAAEKERRLQVEKEKQELERRKLADAKKALEDAQRQERQRQLEQARQREEAERKAREEQQRLEEEEETQRRQERERNAKEQRRLEEEERQRSLEAATRQRQQQHFQAKVLPTMIQRHREKRKQRLALESMAEEEKQSMLVETMLKKEERAFSLAKWLRRWKSMVVSSGRQKVMAASCIQHGWRRRQRQKKHVRAAQAVQRRWRAHKAAKELRRRRQDARTAAHVANRQLAASRQIQRAWRRFDRRRRQQLELEDAAAKVQSAYRGFHIRKKLTTALQLAKFVDGDEFEYDEVNLDEFLGGAPEIDDEDDFEKEDSVDETPILHRHAWFPSTDDDLPPVDHLPAVAIHQTTIQPEAKGSSNQENPEVKTTASTASSLYKRMQRAIAHGRRKQKPTSKPKPDVATTVTWSTSGKKAKKVNVPSLVDRLRRTTASSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJY4</accession>
    <name>A0A6G0XJY4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-hydroxy-tetrahydrodipicolinate synthase</fullName>
            <ecNumber evidence="4">4.3.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ae201684_004214</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:34171"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="4.3.3.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.7" evidence="4"/>
    <dbReference type="EMBL" id="VJMJ01000052">
        <property type="protein sequence ID" value="KAF0740480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJY4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010444"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00950">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00418">
        <property type="entry name" value="DapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005263">
        <property type="entry name" value="DapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020625">
        <property type="entry name" value="Schiff_base-form_aldolases_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00674">
        <property type="entry name" value="dapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF66">
        <property type="entry name" value="4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00666">
        <property type="entry name" value="DHDPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="13">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="13">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF0740480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="293" mass="31292" checksum="CE030692053EF93C" modified="2020-08-12" version="1">MAKLQLEGAFTALVTPFTADGQHVDYEALRRIVEAQITSGINGLVPMGTTGECPTVSHEEHDKIIAAVIQYAAGRVPVIAGTGSNSTAEALRLTKAAKDAGADACLVVNPYYNKPSQKGLYEHFKAIQEVGLPVVLYNIPGRTGINMTPETVAELYKLPNIVAIKEATGSLEQASEIAALCDITILSGDDTLTLPIMSIGGKGIISVLSNAAPEKVLAITDAVRKGDYEAARRAHLSTIKLSKTMFIETNPQPIKKAMQLLGLCNDTCRLPMVQCSDESAEIIRQQLVAHKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XK20</accession>
    <name>A0A6G0XK20_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mannose-P-dolichol utilization defect 1 protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_004078</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the MPDU1 (TC 2.A.43.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000051">
        <property type="protein sequence ID" value="KAF0740533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XK20"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018765"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016817">
        <property type="entry name" value="MannP-dilichol_defect-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 LEC35 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226:SF2">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023381">
        <property type="entry name" value="MannP-dilichol_defect-1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="105"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR023381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0740533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="248" mass="26932" checksum="48CA12CF434AEE7A" modified="2020-08-12" version="1">MAPAPEASATLLYGVFTPECFDAYFTRFDFLQVECGKAVVSKVLGYLIILGSFVLKLPQILKIVAAGNVAGLSPSSFYLEVVTFLASVIYNVIRGYPISTWGESAVILVQNVILVVLLWYYSSAPKTTQLLGVVTFVGLGAGMYHLPSEFDWVLPSASIPLSVAARIPQIISNFRQGHTGQLAFLTLFLNFGGSAARLFTTLQETGDQVVLLGFAISMLLNGTLLTQILIYWKATDAVLAKEAQKKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XLI7</accession>
    <name>A0A6G0XLI7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DM2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_003426</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000037">
        <property type="protein sequence ID" value="KAF0741314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XLI7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002120"/>
    <dbReference type="OrthoDB" id="10251073at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10567">
        <property type="entry name" value="SWIB-MDM2_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.245.10">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019835">
        <property type="entry name" value="SWIB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13844">
        <property type="entry name" value="SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02201">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00151">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51925">
        <property type="entry name" value="SWIB_MDM2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEK-C" evidence="3">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="DM2" evidence="2">
        <location>
            <begin position="105"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="DM2" evidence="2">
        <location>
            <begin position="242"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0741314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="324" mass="36525" checksum="57575576E6505BEE" modified="2020-08-12" version="1">MKLKSELSKAIRKILSTSDLETMSRKMVRKQLEGMFSISMEEYKNFINDEISKAIEEQEEDDSDDEAEEVDEPPAKKPKKSTKAAAAPKKKAPRKKNEDGSASGGFAVEMLLSPELSEVLGITQSSRPQLVKKMWEYIREQGLQDPNDKRTIILNDALKNVFQRDSFTMFSMNKYLKRHVLKPEDLPAGGWADVQRDGESSEEDEEKTAEKERKKAAKLARKIQAKEAGAKPKRAPPAPNSGINAPLTLSEELSDLLGESQLSRPQVVKKLWEYIKENGLQNPENKQEINCDDTLTHLFGEPKVTMFSINKLLKPHLLGKAKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XM89</accession>
    <name>A0A6G0XM89_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_003450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000037">
        <property type="protein sequence ID" value="KAF0741339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XM89"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0741339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="202" mass="22881" checksum="1F2EC7D38187D003" modified="2020-08-12" version="1">MISDHLHLFEATTTAASWHYRSQKIVSTWLSSHGNTSSLVTARIQSTLILRSIFPCFVGPLEIHMFGRREWNSKSMLGVEILAWFLVEQWYISLHISQINREATPSYSSVIDWSDNIVSRIVCLNIVLSHALLTESHFPMSTPSLFKFPDCRFTKRPREQNISSLLCGEMATIAPTKNSRADFSLCTGAKASNNQGHFVKFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XPR1</accession>
    <name>A0A6G0XPR1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_002682</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000029">
        <property type="protein sequence ID" value="KAF0742279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XPR1"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0742279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="145" mass="16439" checksum="B8A73ACBC4F3483C" modified="2020-08-12" version="1">MTQRCYCSDLISHNYARWLFVVEKMKGSEFHFVALLRCISRQHFIVSARDLSDALTSKEMVHEDFAMTHPLNSPGLLLGNAQGVFPGENPRLSIHAVDYDNALCHIICRVSKRADLGRIHILPTLIFHPTASSHQRSTQNVLENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XQU3</accession>
    <name>A0A6G0XQU3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_002364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000025">
        <property type="protein sequence ID" value="KAF0742662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XQU3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019156"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34415">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34415:SF1">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0742662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="241" mass="27279" checksum="1C4D5BF13FB73F67" modified="2020-08-12" version="1">MSDHGGGSDESDLAWCLEASEESDYWDDPSDNASSSEDNGASTPVLSDTRITVSGICATECCEKNCLAEKQDEIEPFLATVARMTKREKQTCMLTCLFLLWKPKSEAADPKKNTRVRFQYRIPLVGDVCRVAFTQCFGVSTPTLERYRKKIAQGEFASNVYGNKQNVNAVTMDMKKVVNWFEDFAKELGEVVPVRVRQKTTENAVTKRVTSTLYTFLPSYMTWQTILSEYEKFVANGWNEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XR96</accession>
    <name>A0A6G0XR96_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_002144</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000022">
        <property type="protein sequence ID" value="KAF0743086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XR96"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009991"/>
    <dbReference type="OrthoDB" id="57748at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00229">
        <property type="entry name" value="SGNH_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="2">
        <location>
            <begin position="47"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0743086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="268" mass="30458" checksum="B7A8D9DF822DA33F" modified="2020-08-12" version="1">MKAVVLYIYVAIRTFFAWIWLRLCRWCAQPLRLILPSNEFRHKIVIIGDGFAAGFGDWVTMDSPGGLARYIANEIAQEESKVRHKWQVINRGILDTDSSQWHPTASTKYFQDTFSKHQLRDADIVLVIVGSMDSKRSPPIPPSQTVTNIQSICDALRKKGKRVCIGTLCHSDVEAQNEIHRATNKQLLEYCNETSGDDLPVKMTPDLSLPIVRRPDAKAFDGFHFNSKAYQQIAHEAMTVLTPMLTAVEWITWKKQLDGVQIDPALYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XRV3</accession>
    <name>A0A6G0XRV3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_002028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000021">
        <property type="protein sequence ID" value="KAF0743176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XRV3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002849"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="565"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="565"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0743176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="829" mass="95470" checksum="54B153F934B9BAD5" modified="2020-08-12" version="1">MDPSEFVGDSQSEDESFWDEAEATVQRRDKELPKQEHIANTTTKAHAQDLPRNQETQVNEATTQIRSLEPTMSGSSSIADDTKHTRSDQPNHAPTPSSRTSLTAEVTSPNQPNHNTEELRAPSQSSEQGKIKEGDIVEVESRTWPGINKIGGTARVTRVYEEDGDTIVDVRYFLGGSERAVSIEYVQITDVYGKKHRQRRSRNFFHEEFAAEYLPTRRHEEFRDQTPNIPQPKKKRVDKPASSVKNSSDQSKKPIYDVSDSENDETPLYQKYRNLEKLVKPATLPATEIILNEPTSSESDEDDEDNDNYVSVLELHSKPRSMEQTKIPEKNFAAQTLSPTLDVPQDEGDRSPTDQSPIRRRKKRKRFVGGYDGDNNFIQPEDNAIDLPEDVQIDTGFKLGKTSKDLLKQYREHSARFEEALQTFQRRRDMYDPTQLQELEEYLKRHIVREEDIVDAILRKLEAKGKSISAIENLKHDQRKSHVNEHAVWLKGRRTSRIGSFPPPPEYEPVASDSDSESDMILKSKHRSREPRQNKRKASLIISAQQNAYIDSSTDDDDYLDRNTFAHETKTRPTKSRDKTHESEPTYLSDTPHDSTWGNESPRRRTPKFQYNRVKSSSLGNTYDDTLHESYRPETIRNVPKSVLSSSQWNWKTLLRQKRRRREASQSLHALNTAHSNQYKPTKWKLRVYRAPLNPNPVHRDLSFSLVNTAIPTETFKGSQPTSKPDQSRADSSLLSECILDFTSEYCPYGWQLEQTEVHKLQVQLSSETFQVLDSHPWYASIPEYARTSGLITKLFRTARHLLFDLQNTEEAYMHDISSKEARHKNSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XT09</accession>
    <name>A0A6G0XT09_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_001398</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XT09"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013077"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="507"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="542"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="575"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="61"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="669"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="682"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="702"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0743744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="783" mass="88222" checksum="4B19F70156BA7CCD" modified="2020-08-12" version="1">MESAADVGAGYEQDFDNDAGLYDISFEDEPVADDAVPLSAMETASVGAVERSSAALKYRRSRSSSELLTHQQPPKVLSKARSFHASSPDKSAVRRLTNAATDTVWTQQFDPRTKTYYYVNAATGECTETKPRFVSKGGAREPMHNAALNIQCNWRAHLSRQDVQRRRAAAPTRTTEPPTTIQILHDAYDRKCKLIRLKIADLERAVENRRPDDAFPHLSDLVREFEESIDAIRSTFSAVEAVIDENQDILHLRCDDINPTLTQVQSSCLRLHKAILSHEYAFLELDAARVNAAWRQFLSWPVPHGALEKAYLRAEGLLRKTMGITAFQSKQGLDPTKLSPHVFDEWHVQVVSLQESIHAYAELMAIEAGKERVVEAPPSDVIEKEEQDVVIEEAPQPKRVRRPGGAYDVAELQRCWARGLALRDRDEAVAIQAEKDAVKARVAELGRIRAAQEKFRLERSHRKLSIWEAVIEGWPVEKINQLALAETKKAAQDGTTPFRLRDSQAENGRTLLQLACWWGHVHLVRYLVEKGSNLGQFDCVNNRFSLLHDAARAGRAEVIRVLIEYGLPVNIVDSHGDTPLHWAARRNHVDAVRALLDLPLKELPTSTTVFTSLQVSRWRSVVTPNCRGKRPVQLTSLFQLRKQLTEYQEIAERGLELYEHQGASEAAMLKRRQGLAPPQAQRRGSPSFTSGRVMQSPDDSAATPSSRNSFVMNNEMSVDERRQREVRVRKATARAVKNFEKEGRKRANVIHASHALKRGLRTSLMNAHDPGDMDIFLDEIDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XUB0</accession>
    <name>A0A6G0XUB0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_001654</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0744021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XUB0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020474"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053151">
        <property type="entry name" value="RNase_H-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47723">
        <property type="entry name" value="OS05G0353850 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47723:SF19">
        <property type="entry name" value="POLYNUCLEOTIDYL TRANSFERASE, RIBONUCLEASE H-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13456">
        <property type="entry name" value="RVT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="73"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0744021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="266" mass="29147" checksum="54E713B40BF00D74" modified="2020-08-12" version="1">MLSPWTLQVVDSSNLQGLDGIPMLLASSLCPPSVSTMDDLTLYTPLKSTRSLTPVQQSLPRFSAEESAVMATFDGSIKFSERVGGFGAILWQLPEWTILWAGYGVVTDTTVNGAEYAGLLAVLSAAIRLHLTDVRVFGDSRLVIQQVLNRMRCTKPHLQTLLAEVHTLNNQLANPSFHHVKRVWNGAADHLASQGLTDRTTGEVTDSSTLDLLRALNWLPHLVHDTRFPLPEHLQYLAQPDSTAASSRSRGGVAYKPGDTPHQFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XW74</accession>
    <name>A0A6G0XW74_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flavodoxin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_000554</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000003">
        <property type="protein sequence ID" value="KAF0744969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XW74"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003442"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF17">
        <property type="entry name" value="NADPH--CYTOCHROME P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="2">
        <location>
            <begin position="17"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0744969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="234" mass="25274" checksum="3F6079B8F948B4B9" modified="2020-08-12" version="1">MGNSSSKQHKKRGKPSVTILYGSSGGTAEGFAMQLGALGRQQGHFAVNVVDLQQFEPRVLPSLSYVVFIVATHGEGGPTDSAARFYKFLTGPLPAKYLKHVKFTVFGLGDSTYATYNAMGHTVDTLMAKRAGQRFYPFGQGDARGRIDMDFAAWKDGLWRALLEDETKGNPNDLPLSPPGSSRLSNLVTPRLKNFLTNSTSSLSSSTSSSSSTRRHFSSSFLSKEAMATTTTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XWC8</accession>
    <name>A0A6G0XWC8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA-uridine aminocarboxypropyltransferase 1</fullName>
            <ecNumber evidence="2">2.5.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">DTW domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ae201684_001152</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 3-(3-amino-3-carboxypropyl)uridine (acp3U) at position 20 in the D-loop of several cytoplasmic tRNAs (acp3U(20)).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a uridine in tRNA + S-adenosyl-L-methionine = a 3-[(3S)-3-amino-3-carboxypropyl]uridine in tRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:62432"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:16092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:82930"/>
            <dbReference type="EC" id="2.5.1.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TDD superfamily. DTWD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.25" evidence="2"/>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XWC8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007137"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016432">
        <property type="term" value="F:tRNA-uridine aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005636">
        <property type="entry name" value="DTW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051521">
        <property type="entry name" value="tRNA_Mod/Golgi_Maint"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15627">
        <property type="entry name" value="NATURAL KILLER CELL-SPECIFIC ANTIGEN KLIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15627:SF8">
        <property type="entry name" value="TRNA-URIDINE AMINOCARBOXYPROPYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03942">
        <property type="entry name" value="DTW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01144">
        <property type="entry name" value="DTW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="14">
        <location>
            <begin position="248"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="187"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="201"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF0744695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="295" mass="33550" checksum="636BEE06053253C3" modified="2020-08-12" version="1">MYYCATCFLAVGAPADVQVPHIRLPLKVDIVFQDKIKKSTAPIGKTVAPEDIQIIPFPFMEEQAPTYDAKKAVVVYPSHDAAIISELEDLDELETLIFIDTPWQKAPSILNDPKISHLRCVKLANPPLESKFWRYHSSGKGCISTIEAVQLMLDEYLAAKPSSKNDVDVSQLLFFFQLVHDHIIHTHTRPDRQLDRAPMSEAEKERQRLLRSQKEKGKKRKLENKLAFKKKLAADLESGVIDGWPAKKCFNCEARTHEARECPELCRYCKVEVHFNGTCPKKGQRQNTVKITKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XXL9</accession>
    <name>A0A6G0XXL9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Golgi apparatus membrane protein TVP15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_000475</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XXL9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018138"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013714">
        <property type="entry name" value="Golgi_TVP15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38894">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38894:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08507">
        <property type="entry name" value="COPI_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0745461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="23414" checksum="1A8279DF4A819E9F" modified="2020-08-12" version="1">MSKPMGSISSDSLNKSSSGEKKSIVDRVRNIKTMETPKLLRYMRVGNMLCCVLQVLAGIAGLASIITFNVTAVFVSLYVMMFGVLFLLFECRLASLEPKIRENFGFLYSYNGRARFIFFIGFMDFGTGGGLGYLAGVIMCLNAFLNFYVMFKHPEFASGNLSSASDPTARYTPANEEATKFIQSNPDIAMQATNYAFAQVGSSTSKSSSYGSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XXX8</accession>
    <name>A0A6G0XXX8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bud22 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_000054</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000001">
        <property type="protein sequence ID" value="KAF0745599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XXX8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000745"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015158">
        <property type="entry name" value="Bud22_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09073">
        <property type="entry name" value="BUD22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bud22" evidence="2">
        <location>
            <begin position="157"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0745599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="304" mass="33610" checksum="AC34F44A7BA3D444" modified="2020-08-12" version="1">MAGNSALKRKRNHSEDEKLNHTASVQFTREIKKIKTFETQKTLKTLAKDPQNPTLKAKVDLLKALDPEHLARRAMLSLGLDPPEKKAKKETISSDVVKALEASLLKHKRLAPLLDTWKVKATERANKLFQEENAVLKQSLEGKPIAPSTRRAASAPESMFVGSLSGEQAEDDIADFLGENKKKNRPGQRARKQRALMEEQRKSGKLPAPTRDSNSKYGPSSRDKERPAAAQRPPRPGSLSNKMGKQKPMAVPAPRPAKATPAPPQRATITAQDKAHHPSWAAKQAQKEKEKIPAFAGKKVVFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XYB6</accession>
    <name>A0A6G0XYB6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_000196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000001">
        <property type="protein sequence ID" value="KAF0745748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XYB6"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071254">
        <property type="term" value="C:cytoplasmic U snRNP body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071208">
        <property type="term" value="F:histone pre-mRNA DCP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071209">
        <property type="term" value="F:U7 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006398">
        <property type="term" value="P:mRNA 3'-end processing by stem-loop binding and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052840">
        <property type="entry name" value="U7_snRNA_Sm-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21196">
        <property type="entry name" value="U7 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21196:SF1">
        <property type="entry name" value="U7 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="1">
        <location>
            <begin position="13"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0745748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="97" mass="11017" checksum="023C0C649919DBF0" modified="2020-08-12" version="1">MKGKRTNRSIIILLQSMLGMEVRIELKTEFIVEGIVEEVGQGTMDLRMSNVKSTSPQGVTMHLDEMFVMGKMILYVHLPDRYDLMDATTQAHVVFQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W2P8</accession>
    <name>A0A6G0W2P8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_019182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000459">
        <property type="protein sequence ID" value="KAF0721299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W2P8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007308"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="86"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="185"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0721299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="308" mass="33917" checksum="49CD51C08BB37825" modified="2020-08-12" version="1" fragment="single">MHCCRYDETHQVDPVSSVNRADLMLCSVERSNISERSSQMSNGMMQSPNVEEGDIINVRSVPTLPTQPKNIADLAKAHHAMTKNAVAKANADAARHKAKVSQLTVELSTLKTKITPIEASTAAASEANEEMIKSLETEREELKSQVQNINAAWTKEKAEHDVVVKTLRGQVSSLEESTRALMFDLDKNQQEKADLTDQLSALNGKLNFANSHVNDLEAVLRKTEAASAANERMMRRLEDEREDLQAQVETLTGTQANERSEYDTTIKLLENKVEALLEANASAGILMADLRAEISSVESNATDMAAMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W4M1</accession>
    <name>A0A6G0W4M1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_018685</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="6"/>
    <dbReference type="EMBL" id="VJMJ01000348">
        <property type="protein sequence ID" value="KAF0722103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W4M1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002152"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000003">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="7">
        <location>
            <begin position="125"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0722103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="320" mass="36278" checksum="FBF4CE64DA625B11" modified="2020-08-12" version="1">MSGSSGSGATMALGDLDVGTLDAWCEKLLTCQPLSEPEVVRLCARAKEVLRNESNVQPVRCPVTVCGDVHGQFHDLMELFRIGGHAPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYKDRVFILRGNHESRQITQVYGFYDECLRKYGTPNVWRQFTEVFDYLPLTAVVENQIFCLHGGLSPSIDTLDHIRALDRVQEVPHEGPMCDLLWSDPDDRSGWGISPRGAGYTFGQDISDQFNHANGLTLVSRAHQLVMEGYNWSHKMNVVTIFSAPNYCYRCGNEAAIMEIDEQMKYTFLQFDPAPRRGEPHVSRRTPDYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W4N6</accession>
    <name>A0A6G0W4N6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_018783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000355">
        <property type="protein sequence ID" value="KAF0721961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W4N6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005673"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042334">
        <property type="entry name" value="ANKRD31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24176:SF14">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24176">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="52"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="85"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="118"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="151"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="184"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="217"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0721961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="309" mass="33404" checksum="867D5F2868E74BB9" modified="2020-08-12" version="1">MRSGQSEDEQLIQAGNEASKEEQLIQAAESGDLKSVRALVANDANVMCADTHGETPLHKASRYGHLGIVKEILDCGALVDLKDEYGWTPLIYASYNGHLDVVKEFLAHSASIDAARNDGWTPLNCASRNGHLDIVKELLAHSASIDASSNYGSTPLHSASINGHLDIVKELLAHSASVDASDNNGWTPLNRAAYSGHLDVVKELLAHNATIDAADNYGWTPLYSASYSGHLGVVKELLAHELDIVKELLERGASYDLTNKNGETARDVGDESIQDIFDTFLMSVSPSSIRFAIELIQKALVDTSAQIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W599</accession>
    <name>A0A6G0W599_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_019038</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000379">
        <property type="protein sequence ID" value="KAF0721621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W599"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.10:FF:000001">
        <property type="entry name" value="50S ribosomal protein L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="entry name" value="Ribosomal protein L10e/L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01342">
        <property type="entry name" value="Ribosomal_uL16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047873">
        <property type="entry name" value="Ribosomal_uL16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000114">
        <property type="entry name" value="Ribosomal_uL16_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020798">
        <property type="entry name" value="Ribosomal_uL16_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_uL16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_uL16_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01164">
        <property type="entry name" value="rplP_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220:SF13">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL16M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00060">
        <property type="entry name" value="RIBOSOMALL16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="Ribosomal protein L16p/L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00701">
        <property type="entry name" value="RIBOSOMAL_L16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0721621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="134" mass="15356" checksum="A685C225769DF45C" modified="2020-08-12" version="1">MLFPNRTKYKKQFKGILKGKTIRGSKIIYGKYALKALKEKRITSKQIEATRRAIVRKMKRLGYLWIRIFPDTPVSSKPNENRMGKGKGAVSFWVSKVKSGQILFEISGISFENAKKVFQAGANKLPIPTKFIYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W5X2</accession>
    <name>A0A6G0W5X2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_018410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000333">
        <property type="protein sequence ID" value="KAF0722467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W5X2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019983"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0722467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="107" mass="11933" checksum="475868999621B057" modified="2020-08-12" version="1">MAIQMKFFNTRPSSCLQCKKFGTSYGKKDRLGRGYYCSQACLLANKSIPRHSWSTTSDTSTSDVSDDQMLDEPSSREASFVNYFDDATAAAVARSCHHDDQIDGFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W611</accession>
    <name>A0A6G0W611_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_018394</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000332">
        <property type="protein sequence ID" value="KAF0722485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W611"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0722485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="95" mass="10686" checksum="73ECF89CCDB6AEB6" modified="2020-08-12" version="1">MGVLYMNNENVPPTTRSAIMPNRRLSSNLSLVRSHENDCSTRLPFGLEQRVGTSSVEQQSSPHTLYWVRPPCINLSHYVNFLASDPSKGHPQTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W615</accession>
    <name>A0A6G0W615_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_019128</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000406">
        <property type="protein sequence ID" value="KAF0721467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W615"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015084"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0721467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="141" mass="15699" checksum="E77895685638C6D9" modified="2020-08-12" version="1">MHRLLRVSDGLHAGDIDDEEGMCCATPELSNRDGSFSAESDAEEVSTILASKVEDARTQGLTEVEAQQLHTLLAEFHDVVRIRFGCDPPVKVAPLKVHLKDGAIPVKSGLRRYPPARVAFLEKHVRELEKAGLVYRNRRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W6I8</accession>
    <name>A0A6G0W6I8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_018725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000349">
        <property type="protein sequence ID" value="KAF0722089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W6I8"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0722089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="122" mass="12886" checksum="D9CB77445D8C0FB7" modified="2020-08-12" version="1">MVPSLLLAPHFCASCGKFGASIPGNSRHSNNVFFCSKPCFKLHQKVRRQGSNPRLSIISEVSDVDPASCIELQPVSCALCSLGRGTSATRRRAKDDHSGSVAEGSTAVVSTCSCGTLVGFWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W6P4</accession>
    <name>A0A6G0W6P4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_018239</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000326">
        <property type="protein sequence ID" value="KAF0722762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W6P4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005670"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0722762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="592" mass="66114" checksum="D32043DEF36FE8EA" modified="2020-08-12" version="1">MEGKRRCFPHCCPSHVYSSVCGSSVVVRVQGPLASLRDVVTYLRFDACYENPVAVGDTIEENSVLSNLRRQTHVVGEWIASHYEVVDENVPSRMCEFSPKTQSTLGWHYRWVGGSARQQRRAVHYLRAYVFAREPPRLRVLAVVESTPFIVMSYRRACKSCQRQSPEDERSGLKCQCEGIYKLAESSPIRHFQQTPLHPPEPATAHFPMEMTVPGCEDRLEDALATIHFFISTFPVSVLAPYLEPLDTVLRSTVHPPIAHPILHQIQAHTGAPSERLAGWSQTLAALGVVLGFSTESTPFLHAFSAAHASSLLCKPDLERSYAMFVQHHYSNVARALMPLNITPHALSDEILTLCAVLHAEHPAAASICLEKCRGFRPAVAFENFVAQMREIYMSFNAPPQAQPVSSNRPLDGCWRFRSMSIMFMSPQLSPSILSLMRASYMGLTFQIIQTSTCLLMRSHHSLTDKIWAEFQLDGTPQVHRVFPNGESSMACFDGLVHGDYLGEIVSSNAVALTLFSWPASPVSRLCYAIHIHIARVGDGALAVDVRVVASPEKAPIADYWCMSVHQRVATYDRSNECPVVAFRLDYEMQTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W7Y1</accession>
    <name>A0A6G0W7Y1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_017800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000313">
        <property type="protein sequence ID" value="KAF0723179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W7Y1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004123"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="287"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="320"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0723179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="458" mass="50469" checksum="D5509B355451414F" modified="2020-08-12" version="1">MADPAAGVAADTTTLGDDFPSLGLSHTWLVAWKDDMLAKGRISPASTTTDVCEAVVKPETIESNCSYAQKHINGPTQGIGKATHFVSHAWKYSFCDLISAIEIFALSLPPDEAKSAFFWVDLFVVDQHHAPSRPHSWWSSTFVDAIRSFGKVVLVFQPLLDPIPLTRAWCLWEIFTAIQTGASISLAMPTEQWTNYRVSLRQDYHAVIDSLQRVDARNAEAWNPRDKEEIFHAIEVSVGFDELNRRVRQLVAGILLVGVTRHACLDNNLQRITDILALEPDINTVSTFLTPLGVASDMNSPLVVDFLLARGADINARMAWGHTPLHIACRAGHADVVRLLLLGGANQDLVNEAGRTPLEEADVMAHSQDDVAAPTNISTLAPELEEAIKTAKNAIYSLTKSDINELKSWMKPPICCAKVMKCIVLILRHPAPRNSEELTAWWEVGSANFSQTLAFTQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W8R1</accession>
    <name>A0A6G0W8R1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="10">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_018378</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="10"/>
    <dbReference type="EMBL" id="VJMJ01000331">
        <property type="protein sequence ID" value="KAF0722541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W8R1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019051"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18794">
        <property type="entry name" value="SF2_C_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="entry name" value="HRDC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF153">
        <property type="entry name" value="RECQ-LIKE DNA HELICASE BLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="40"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="250"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0722541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="527" mass="57810" checksum="BD6980CA23435EBB" modified="2020-08-12" version="1">MQRHLVKWEASSFPWSSSALKLLQSISSSQSFRPCQQAAINIAQSGYSLFLQLPTGAGKSVCFQLPALLDKNKTTLVVTPLRSLLNDQKQNLVRVGLSDRALFLTPGDVPQSIPDHTALIYATPEMILQNPSAATLVKSLVDSNRLSRIVLDEAHCVVEWGNTFRPSYLDFARYSKTHLPHIPVTFLTATAVPELVTSTASLFGRSLQPLPDPAHPLPASAPTTLVAVQQMLDRPNLRLQVLPKSSSVIAVMAAMLRSKEPAIVYVLSQKDAESVAKSLAAFGIDAQPYHAGMSDAARKRAQYLWMSGKSSVICATVAFGMGIDRADVRHVIHHSIPLSLSGYMQQIGRAGRDGQPSVCTLFYAPGDRRRAEFIGSGGDDFVDVSTFRGIRDVIDLVTSTGCRREILHGHFGYPLDECCRNCNCGDAVLIEEDDSKLQVEAPRQARRGWKSNLDVEILYQTLQQQAKKQSGPLRRDDIVSRKTIETILAHPPASKVELAAIRGVGQAKAEASFDILMAHLRRKSKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W8S0</accession>
    <name>A0A6G0W8S0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_018341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000330">
        <property type="protein sequence ID" value="KAF0722608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W8S0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008119"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016467"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36489:SF2">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36489">
        <property type="entry name" value="PROTEIN-COUPLED RECEPTOR GPR1, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0722608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="470" mass="46360" checksum="FA5E4164358CC933" modified="2020-08-12" version="1">MSTDDSRTNHANDVASSLLDLLKVKTEKPEKGKPKPSQSTEAPTEEPTRAPKTTRTPEDEKTKRPKPSHPTDDPTEEPTQAPTVAPTTNAPTDAPTVAPTFAPTDAPTSAPTEAPTDAPTVTPTDAPTDAPTDAPTYAPTDAPTDAPTDAPTDAPTDAPTDAPTDAPTDAPTDAPTDAPTDAPTDAPTDAPTDAPTDAPTDAPTDAPTDAPTDAPTDAPTDAPTDAPTDAPTDAPTDAPTDAPTDAPTDAPTDAPTDAPTDAPTDAPTDAPTDSPTDAPTDAPTDAPTDAPTDAPTDVPTDAPTDAPTDAPTDAPTDAPTDAPTDAPTDAPTDAPTDAPTDAPTDAPTDAPTDAPTDAPTDAPTDSPTDAPTDAPTDAPTDAPTGAPTDAPTDAPTVAPTDAPTDAPTDAPTDAPTDAPTDAPTDAPTDAPTDAPTDAPTDAPTDAPTDAPTDAPTDAPTSDPTDASTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W970</accession>
    <name>A0A6G0W970_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Inner dynein arm light chain, axonemal</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_017718</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the inner dynein arm light chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000309">
        <property type="protein sequence ID" value="KAF0723378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W970"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011623"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019347">
        <property type="entry name" value="Axonemal_dynein_light_chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13183:SF0">
        <property type="entry name" value="AXONEMAL DYNEIN LIGHT INTERMEDIATE POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13183">
        <property type="entry name" value="AXONEMAL INNER ARM DYNEIN LIGHT CHAIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10211">
        <property type="entry name" value="Ax_dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0243">Dynein</keyword>
    <keyword evidence="3" id="KW-0505">Motor protein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="176"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0723378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="255" mass="28719" checksum="77198F757C1CA3CE" modified="2020-08-12" version="1">MLPPQPSLVKYDSPILISTTKDKKASGGSGKKGKKEHSTSATASNTEKNGIPSIANASSTQTEDILNSILPPKEWTEDGQLWVQYVSSTPATRLDVINLQEQLDMRLQQKQARETGICPVREELYAQCFDELIRQITINCAERGLLLLRVRVEIRMTIAAYQTLYESSIAFGMRKALMAEQKKLDAEQKLKQLEADRNELAAQVEELKLRCDAIQKREEEKRLADEKKHNDDVELLKKANEQLKANLESLLAAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W9E6</accession>
    <name>A0A6G0W9E6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_018152</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000323">
        <property type="protein sequence ID" value="KAF0722800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W9E6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014153"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026115387" evidence="2">
        <location>
            <begin position="18"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0722800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="149" mass="15220" checksum="D20169487911A335" modified="2020-08-12" version="1">MRLLLPIVFAVATLAFSQDQAVRSNGFEESRALLATPRRRSGGGGGGQRGGGGGGQRGGHRGGGGGASIASVGRAALKGSGFSAHSMASLAGGFAGSAARSYLQSDVAADVVAADANDYAGGRRSNRGFKRGRRRSGSKRRPRRNRRYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WAM7</accession>
    <name>A0A6G0WAM7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_016947</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000273">
        <property type="protein sequence ID" value="KAF0724282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WAM7"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0724282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="80" mass="8620" checksum="162F5090EE02E405" modified="2020-08-12" version="1">MFGLFKVVLPSSKTHPGSLRYSSSAKPSHGIHAAPVFRRSLAGLTTTAKGNPAVTTEWKKGDNVSVAYKLSDRMFEIDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WAP9</accession>
    <name>A0A6G0WAP9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_017037</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000276">
        <property type="protein sequence ID" value="KAF0724224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WAP9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015595"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0724224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="166" mass="18798" checksum="EE4F466FE4ED3962" modified="2020-08-12" version="1">MGDEDLAVMLSNRDEQHLLHLVEVIGRYAANARLEERDDIALLHEESSRALKNQILDLEGQILSLMASKASQEEALRQTREECAAYQARAGFAQLRSREDGSFDDDDTRHAHESKGVKLDVSKFSGQESDHVMRWLLQVTIAADALCMRKESIKVAFAMSHLYARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WAW8</accession>
    <name>A0A6G0WAW8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Golgin subfamily A member 7/ERF4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_016930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000272">
        <property type="protein sequence ID" value="KAF0724388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WAW8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020728"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0724388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="141" mass="15486" checksum="EF1B264C2D2446C9" modified="2020-08-12" version="1">MTIFRKCLPYAHTGRRGREMSEELREPLLPEEVILDDSESDASDNEEGGVRAIILSRLKAVGRVTTDGLTSKYADTFSAPLERLMSEKEFRAAIGAINQTLADYFPCLCCVVYAYVGYVATCGLMSCCARPCTSEVGQLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WB29</accession>
    <name>A0A6G0WB29_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_016845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000270">
        <property type="protein sequence ID" value="KAF0724437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WB29"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013496"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0724437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="112" mass="13274" checksum="40002AC909267CB6" modified="2020-08-12" version="1">MTTLWAVTIDLFSWERENYEMFIQNCAVLTNMHIRFLPLRDLDSREYSQYLNRLLSSGKKRVDKDSATTQKYPKKRKQRIDVIVFSLEDAFRDNDDDFGGNLTNNSIFRLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WBZ1</accession>
    <name>A0A6G0WBZ1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CAAX prenyl protease 2/Lysostaphin resistance protein A-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_016640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000264">
        <property type="protein sequence ID" value="KAF0724768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WBZ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013657"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004175">
        <property type="term" value="F:endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080120">
        <property type="term" value="P:CAAX-box protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052710">
        <property type="entry name" value="CAAX_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1/LyrA-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36435:SF1">
        <property type="entry name" value="CAAX AMINO TERMINAL PROTEASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36435">
        <property type="entry name" value="SLR1288 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 2/Lysostaphin resistance protein A-like" evidence="2">
        <location>
            <begin position="164"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0724768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="307" mass="34138" checksum="38B62191206A55BA" modified="2020-08-12" version="1">MSVAVDRHENGLIAWLSPSNGSGVKLHGSLVAGIVAWVEVIAFLGETFLSMIISLACRSLFHAAAALVWPHDTTTTSLGDVVWDALFVCVYLLRRSAGNFHQPSISTWITRLGLHPTALSQLTRGWIVYQIAGFLAFVGYQHVANDWVMSWANYYGSSKDSVQWPHVLEILVLSPLKEELVFRGLAYHLLLNRIPKPMVAGLVSSILFGCIHLVNLKQSKFSTMYVLIQMGLGVEIGFFYSLTYARTGSLFECVVLHVVNNVLSSFTSTEMELSSSPWLAALLVHSILWYALLIYLSHQALRAQTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WC75</accession>
    <name>A0A6G0WC75_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_016433</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000253">
        <property type="protein sequence ID" value="KAF0725035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000022"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19953">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039776">
        <property type="entry name" value="Pds5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663">
        <property type="entry name" value="ANDROGEN INDUCED INHIBITOR OF PROLIFERATION AS3 / PDS5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663:SF0">
        <property type="entry name" value="PRECOCIOUS DISSOCIATION OF SISTERS 5, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20168">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1040"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1050"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1087"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1114"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1152"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1195"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1210"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1248"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1266"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1287"/>
            <end position="1298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0725035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1342" mass="151071" checksum="A7E6AE1F6C68F97D" modified="2020-08-12" version="1">MVRGKSENESGNDLPKTSKGKGKTKDKADTSKPGSTNVAKRLTAELHRLRGTSNGELEESETAALGREFTSESNLEHPDPHVRLLVASCVAELLRVTAPETPFGSEHELYEVFLLIVRVLRETTKVTDITWFGLLETLATVKMFNLAVGLEPESGDISGDLVVNLFRCLFDRIQDDHSAKVEANMVSIMTGCLEEYDSVSPALLETVLEPLLHGDEHPRAYHMAQQVIRKSSDHLQNALSLFFNSVLVDAIGNHHESELKEHAHALIYETHKIQPGLLLYVLPNVCLQLQVDEMEIRSNAIALMGRLFASSHADYGAQYMKNFREFLGRFRDVKKEIRLQMVQVCSIIAQRKPDLAVLIDAELQLRLQDQEWEVRRAVVNEICDLAAHSLSIVSQTCLREVGERMKDKKVVIRKEAMTGLAQVYAAHVSTSWTNGNMEISTAAKELAWIPDYVLKCFAYREQELRLRVVQLLDDILLPKQTTDVYRMKGLLFIWRHLDAGSKEALKRILMERMQCRKIITRFIEVKNQLRGKSQANLLTSAKQSLKELGSLLPETEGIAGLVEKLVTWKDMKLVKHLDILCSAGSQTNAIRQAREDLIKMVGSKTPLGEFMKNICRKLAMTTVNSSSLTCLLSMLEDENNKSCSEILQMVGSVCPHLLASHLESLEQLLSLSPKSSCVFDLFVSLTKHSTNLDEIPTSMKKILINHCTSGSVDVVKKSARILVKLFPNEVTSFVKKLLKQAEFSEAKLQALAIFVKHAPEAISDAPTLFKQTLEVYENAAKKRDVKCLALNLLTNLVLHKDLHDSSRHVLDLCFQHFQGTNYKTIAPLRATAASSVLKMTRVPAIENQIEIEEWHSLGYVIEDPEDIVRRAMLKKLTANLLHHPINHKYMCYLALACTDPNADMKKEVKTLLQTAVQRMRRMYEARVDQSNTASSLMVPEYALPYMIHLVLHSPWDEVSMNSLYFLLEALVSHAASEADNISFLLQMLHKLSLCHDATDPSAAKMYEIIDSCTTWLKKRIKNQINLKAYPGQIYLPKQLFQPGRKDETKSSTANEISTMPETPKQKKRPAPIKVSESDKASKKVKKSPTPTKVTPPSRRMPSRLAKNDANLADQDSDVEELQEELPMQTYKEQSSRELITVDDDEESTNENLGEHSDGDESKANDDKEDKILSKANEETKSDENETNENDEKTSARVKKAKKHSAKATADEADTISDEEETKEDGANINNGDKPETPRLRKSPRSQKIPLTSVSKRSQTNEAVKPPAKDQQEPEDEPTKKTATADIDTSKKGKKRVDLSDSSAVNKKTRYSTRRTPDKANEPEGNANEEEEEMTSFRSRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WC84</accession>
    <name>A0A6G0WC84_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Vesicle transport v-SNARE N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_016443</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VTI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000253">
        <property type="protein sequence ID" value="KAF0725045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WC84"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000013"/>
    <dbReference type="OrthoDB" id="430637at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15862">
        <property type="entry name" value="SNARE_Vti1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000002">
        <property type="entry name" value="Vesicle transport through interaction with t-SNAREsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.400">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038407">
        <property type="entry name" value="v-SNARE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007705">
        <property type="entry name" value="Vesicle_trsprt_v-SNARE_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF84">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05008">
        <property type="entry name" value="V-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Vesicle transport v-SNARE N-terminal" evidence="11">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="69"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0725045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="211" mass="23865" checksum="B304DEC9B80F663A" modified="2020-08-12" version="1">MTTIFDSYDEEYKSMTKSISTKISEIATYEDEPDKKRTAITHTSDLLTQASQLIQQMDLEVRSLDAATKRELSKKVDQYKKSLKSLSDDLKTIKDREEKQGLFGNAEARSRMANATQKLQQTGDRIKAAHQTVLETEEVAIGIQEELSRNREKLDATHNKVKGVNDMARSGGRILGRMSARDKRQKLILYGVMGFMILAILIVLFSTIFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WCE9</accession>
    <name>A0A6G0WCE9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_016386</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000253">
        <property type="protein sequence ID" value="KAF0724988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WCE9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011896"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000009">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000076">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000037">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="209"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="28"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0724988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="436" mass="48577" checksum="9732728EF1BEA40A" modified="2020-08-12" version="1">MSKSGDENSLEGGDIWGEIEPEILSMTNDELKQRIRLLDNEIRIMRSDITRINHESQTQRERIKENNEKVKLNKQLPYLVSNVVEILEMDDEDDEQDGAAADADVGRKGKSAVIKTSTRQTIFLSIPGLVDVEKLIPNDLVGTNKDSYLILEKLPAEYDSRVKAMEVDEKPTEDYSDIGGLDKQIQELVEAVVLPMTHKERFDAIGILPPKGVLLHGPPGTGKTLLARACAKQTDAIFLKLAAPQLVQMFIGDGAKLVRDAFELAKEKCKDKDKGGAIIFIDELDAIGTKRFGGEQSGDREVQRTMLELLNQLDGFSSNTKIKVIAATNRPDVLDPALLRSGRLDRKIELPHPTEEARARILQIHSRKMNVDMEDVNFDELARCTDDFNGAQLKAVCVEAGMLALRREATIIKHEDFMEGIGVVSAKKKATLQYYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WD30</accession>
    <name>A0A6G0WD30_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_016350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000250">
        <property type="protein sequence ID" value="KAF0725119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WD30"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014340"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF37">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="240"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0725119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="399" mass="44665" checksum="5AEDAE6455DA0077" modified="2020-08-12" version="1">MRDQVLAGDCPEMPYTDRPPRAPPEALLTQSGIRRLTQTEADIRPGDVDTRKDFTGRDGHEAVLVDDNTKQGSNFSYLVTEHHQGLPPPSIFTLQAPPPDLDQRTLPLEVVIREGVDLTSEEMESQLALIPEIPPQLPFDMDQLDYGEVGQSEEERQQMREVLDKYKAYFIRSGNGLPPPARGTVCDIDVGSAKPIAHRPRRVRPEHLQKLFELLRGLLSYGLITFSNSQWASPIVIVLKKGGSDIRLCIDYRGINDLQELMRSPMPTLDAMLSGFHAVQWLLSLDNASGFWVVRATKRARLISAFICPLGHFEWTRMGQGLKNAPMIYQRMITNALYGFVDLPPGMNEVDEDGEPRDMFQIGHVRDASSMPAPANRPSFVDDHGLESRASSGRRLSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WDK8</accession>
    <name>A0A6G0WDK8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_016199</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000244">
        <property type="protein sequence ID" value="KAF0725302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WDK8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020785"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939:SF1">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939">
        <property type="entry name" value="PROTEIN CBG22215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0725302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="201" mass="22712" checksum="BCA34DB403833FFE" modified="2020-08-12" version="1">MFTHDYFVAWFESVLDELDALNKANVVFALDNAKYHRGKPAGTPTGAMKKSSMLEACEAYGLPVDPTSSKVVIWEKLKNYLDLNVKPQIETMAAERGHLVAWTPPYHSDLQPIELVWSYIKGKVGRQYTADTKFEDVRRRLDEAFENLSSSTIFNCITHTEKKIADISKHINDLDLADHSVSDGDEAYQSDMSSDNDFDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WEN1</accession>
    <name>A0A6G0WEN1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aspartic peptidase DDI1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_016552</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000259">
        <property type="protein sequence ID" value="KAF0724864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WEN1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002927"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0724864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="143" mass="15946" checksum="E48EE60EC4017DDC" modified="2020-08-12" version="1">MSVVHLRAVEWLNLPIDRGKSTKINGLGSNSIRTLGTVPVKLVIGNGIAYYLELDVCDLGNVGFTAVLGMDFLSRACMTIDTERREISLPDGERVSLLYQPTRYHRGDVQYLETSKQTWIAPGESTVINIRRTLAVDPQECEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WF34</accession>
    <name>A0A6G0WF34_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_015675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000229">
        <property type="protein sequence ID" value="KAF0726011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WF34"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009516"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="168"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="322"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0726011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="597" mass="66986" checksum="A71A16442D072BEA" modified="2020-08-12" version="1">MDAEVARLKAELTAKDETLNQLKVKAKAFAEAMTNEKKGLEGQLTQAKNEMNDLKTKAKAFADNVKAQILAEKERVQVLEKQLQEARAATPVATQAESPSVDKAAIEHQFRAQSEAQLAEMRQSIQRLSEESNGRMNQVVAALQSMTQSASSDVTQLLNDVQVVVNAKLALERQVSTLESDKQLARTNSASLADKLRSEMNAIEAECAKLRSQESTLRMEIGQAQQRARELEAELAREKMSNSSQTDGLQDTVRKLESELAQERMNHQNQVQDQVRKLESELAEERSSRQNQVQGALQEWQAKEAAWAAEKKDIVQKHEKFLKEEEEKKQKVKAYVAALTAEKQKALEDVDKQLKERDALHEKRMAEVKAKTMAKFTEHESVIKKGQEELEALRQLMASTTQKYEAEIKMLQTKKKEAEEETMEILKKKRLAAKAETQKLANDLEGIQKRAAMLVDVTGNKCSHQAKQLEVLQERVLEAIHVVSHQKKCDISNLNELSQVVTSPRMNAANLPGPAIGLNKIDEDVSHVIDQMTALSNVTERLVDLTLEDSDLSLKEIVLDRMKKQFSACFVHQYTKSDEAGLLRQRSSSATAPESPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WGC6</accession>
    <name>A0A6G0WGC6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Superoxide dismutase copper/zinc binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_015706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000230">
        <property type="protein sequence ID" value="KAF0725936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WGC6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009507"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006801">
        <property type="term" value="P:superoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0725936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="26400" checksum="402B5A99AEFE087A" modified="2020-08-12" version="1">MSTPTTVVYTFNPASSGGVSGTITTVVGAPGSAEIKANLDLTNANWSALQAFDGNCTGSPVTEFTWHIHSVWNNTKSSEFTTGCSLAKAGNHYDPDFACGPNSEYIKDPKCAGKTYACNTTTYAANPSACEKGDLSGHVGKMKATDGKIVASWSDKGNYPSVAEHKPTWNIMLHAVCGSVTPRFICATGAVSTESLDAGSNSTNATNPSTTKANEVTTPAPGTVTTTTAAPTTTKANSAVKVSVLAALSMAVLAALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WGK0</accession>
    <name>A0A6G0WGK0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_015470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000220">
        <property type="protein sequence ID" value="KAF0726252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WGK0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010093"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="377"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0726252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="415" mass="47669" checksum="0EF5C4A3E88738BF" modified="2020-08-12" version="1">MPKKRQGRKEPKAENAKENDNEIPESTKFDASFVIGQGRHDVITIWREMTKEDKTVLLALDEEDIIHARRRFQQRFPQYEIPPISMNSEEVSSIQALFLHAMETKQGQIAPHEQLSIEAAMMVFYLEERLLFSIVRRDINRKSSIVLLYFIWTSSWPWLGLSVALFITFSSMTTCQLIRDGFCSTIQWFLIQHEDPFHVEWHAHSYITALLLLLLSTGSNMSVYITIGVLLVIPHIVFALKSKMFAQGAADQAALDRIMSAMSLINKIILVFYCWDSYSSLFMVVALFFVDIVLALLTLSFQISAELLYVCRIFIVRMIPQALWSRYEAWIESNRYGALVIGLFPSIFGPLVVYYTWDWSFPFGLIVRWSSFILVTQLTPSGLIAIAFQLILLIIGLPLYAIRRLSGSKEPNPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WH54</accession>
    <name>A0A6G0WH54_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RxLR effector protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_015259</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000214">
        <property type="protein sequence ID" value="KAF0726491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WH54"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003361"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026123180" description="RxLR effector protein" evidence="2">
        <location>
            <begin position="34"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0726491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="13858" checksum="4E521FD273563E93" modified="2020-08-12" version="1">MKTGPQTLVKFSRHLSAVLFATCALANAMEAVAEPNNGQAAVVPKEANLRQEGGDADQSKEWGRWGWGGLVWWIKHQLGHKHTRDTPKHTPQDASRREISPLGTHLPRAHLDPIKTPTRHVWHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WH94</accession>
    <name>A0A6G0WH94_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nuclear segregation protein Bfr1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_015158</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000213">
        <property type="protein sequence ID" value="KAF0726530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WH94"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020910"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042175">
        <property type="term" value="C:nuclear outer membrane-endoplasmic reticulum membrane network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039604">
        <property type="entry name" value="Bfr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027:SF2">
        <property type="entry name" value="LEBERCILIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027">
        <property type="entry name" value="NUCLEAR SEGREGATION PROTEIN BFR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="427"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="29"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="149"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0726530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="498" mass="54378" checksum="CBADA323349C387C" modified="2020-08-12" version="1">MADSEEAPTTTTAAPAAPSKVTYFPKPDKAVHDAEVAKLEAEKKKTQDRMNAIRAELDAIQSGRSGFSEKIAEAKKLYLELKEKKEQLYTNKTQLKVNLDKAMAAKSAHRESQKSIRDQVSFKSVDEVDKRIAELQHEQNTKSMTLMAEKNLIKEIESLQQAKKVLAKAAAQKDDGAKFDASIDDIRAAMKAKSEEITAVTEQFNAQKAVLDKLRDESNAGGRDEYPKLVEERKALKVRVDEIFTAIKELRAKFKEDNDKYFQGVRAKREAQKAAREAEEAKVKAEFDAKMAEYEKELAKIHPYQDEQDLCQSLIVYLEKTYGKELKASSDAAAASAASSTVSVELDGLKPFKRDDEDFFATKKVGKKGKKASTGSASTKKEAKLVLPLAQLQSFATVGLTPPAFVSAVAESIEAIKAKKEWFAAQTERSTPAATITAAAPATTTASSPKKQPKKNAKGFNADDQGAFPSLSSSTSVAVDHGSAWGPSSSAVPQEESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WI09</accession>
    <name>A0A6G0WI09_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Plastocyanin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_014996</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000205">
        <property type="protein sequence ID" value="KAF0726854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WI09"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019493"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48267:SF1">
        <property type="entry name" value="BILIRUBIN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48267">
        <property type="entry name" value="CUPREDOXIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="3">
        <location>
            <begin position="171"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0726854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="329" mass="36406" checksum="21095CBC7140DA93" modified="2020-08-12" version="1">MVRILGFETSWLLCGFLSYLFVRVIMHVLGIDTSWLLGGFLGYLFGDTAIKNHAHSSTHHRVPLMKNWRAFESPLVQPATIDMRTGGHLEMYVGETLHAWGGGAPSGVVFGFAERGSKATFPGPTILTARGVPVSVTWSNRIGPQPHLLHRNTEPSLMIDASSCYPKCGVPMAIHVHGLEVPAKYDGLPTHTFYHNTTYYAYYTNRQNPSTKIYHDHALGLAPLNTWAGMIGTYIVQDPELEERFNLVGVPDMLLIIQDKLIAADGSLRYTEDLPCTPVHSTHWVPESHGSVITINGIVMPLLTVEARNCSLSVGQRRKCPNIHVQSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WI63</accession>
    <name>A0A6G0WI63_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_014892</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000204">
        <property type="protein sequence ID" value="KAF0726898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WI63"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017200"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="8">
        <location>
            <begin position="204"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="9">
        <location>
            <begin position="747"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0726898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="876" mass="98977" checksum="BDC1C98D5D3188BB" modified="2020-08-12" version="1">MFAKNECFRISHAKVAEINQRYAQRRQDRRSHQASTLRQAQPSRVRRQADVTVRTTAEELILSHCNLEELPRLAEDIVQLPEMSFSAFQDALRSGDIMSIALIQCVDDLQLNSTSTMDAEVVGSSAAATPYMKTWKSLKANPFYALLREYEDVFPEEVPDTLPKDKGVRHEIDLIPGTKWCVTRQWPLPMEQVEHIDAFFEKRRKAGHVRPSTSPHSSPTFCVKKPNGGWRIVHAYNKSNAATIPAQTPIPRKDVIIDGMAGSTIFSTLDLRDGFYQTLMRVCDIPKTAVSTPSSMLWEWLVMPQGLSNAPATFNRLVTGKLRPLRNFAPSYFDDIYVHSQKTDTRSDVEVHRGHLRAVLKVLRESGLYANLQKCHFGVPEIPVLGDFVGVNGCRANPSKIEAIVSWPAPANVTQLRSWLGLATYLHKFSKNFASIARPLSMLLSKDEPWNWTAECQTAFDGIKQSLVTAPILALPRFDRPFSVVCDASVRGIGCCLMQVDDDGKNRPVSFQSRQLRPAERNYPVHDLELLAIKYALVKFRIYLLGSKPFVVYTDHASLKYAVKTRHLSERMARWLSFFAKYNMTMEYKPGRENVLADALSRRPSTTNEPEKLSAIYTVHSDLYDRIRRVYRNDPALKPIVAHLSAPQQAVNRVAQMDRYSLRDGLLYYTRAATASPCIVIPCDVALRTTLLGEFHDTPSGGHLGRDKTYVSLARSFWWPRMYKSVAKFIAACDTCQRVKASPSVQAPLQPLEVPDELWTSVSMDYIFGLPQDQRGNTGIWTCVDRASKYLVALPVKASITAEQSAKLFFDTVYCRFGLPSSIVSDRDPRFTSKFWAALFTLVGSRLNMSTSEHPESDGQTERANRIIEDMLRSYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WIA6</accession>
    <name>A0A6G0WIA6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_014914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000204">
        <property type="protein sequence ID" value="KAF0726923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WIA6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021084"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0726923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="384" mass="44380" checksum="FEEEF7863C8BBFBD" modified="2020-08-12" version="1">MLASPSKPMGKKAQKDLALLAKQHAAARTAAARRRKQQQRAREKGEKSELLKAEQEMLATIHVLMKKFKYPVVVLNRLPPEIKEAVLENRQRMRVGQDMKKRLEELYEVQKILAKWVFAHNPHEGVQPKPTMMETTLLGHDRCRSFGQQWLCEKALRMALTAHPYEPFKGKVEDSIVSWPHLSEDDTGTSLEAVQFHSQYSVMGDYRDVADVFWDLYVKPKPQFTVEMIDKLHDEMLYFSVEYGPLKSRFLNLACLTRLKHRIVVTLTTIAFDERFPMNDDESRIHGVGWCAHGMHSSKDLMTVDRMILDEMGEGVTLCRQSCLQYTPVKKSGPLTLEEIGQLVHYEPKDGEPREIVIGKYQEMTEVGFTMQRDLLIRPHFPIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJC0</accession>
    <name>A0A6G0WJC0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 16">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="11 16">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">Ae201684_014589</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 16">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="11 16"/>
    <dbReference type="EMBL" id="VJMJ01000198">
        <property type="protein sequence ID" value="KAF0727329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJC0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011069"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000026">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016652">
        <property type="entry name" value="Ubiquitinyl_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041432">
        <property type="entry name" value="UBP13_Znf-UBP_var"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF664">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17807">
        <property type="entry name" value="zf-UBP_var"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016308">
        <property type="entry name" value="UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 11 16" id="KW-0645">Protease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 11 16" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7 11 16" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10 11 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="20">
        <location>
            <begin position="152"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="19">
        <location>
            <begin position="311"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="18">
        <location>
            <begin position="605"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="18">
        <location>
            <begin position="670"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="581"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="594"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="766"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="204"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR016308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR016308-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR016308-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR016308-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAF0727329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="804" mass="89737" checksum="2EBBB8196A16C8A4" modified="2020-08-12" version="1">MDKFGAVKIANERSVVYKEECVLSFDTPFTETGIYTNLSTFESFGEPYVHADSVKTNQKVYLHQKFVRTGVKKHALEDVKKLAIGVEGGFQEDEEQVEKNLSIVVFNGKDKQVYELADPALPEIIRQSANSVLNHQGHYVAEQVKSWQEEIQTSQYAFDLIQLPREDCAPISGDPSTWICSSETCDKKENLWMNLSDGYVGCGRRNFDGSGGCGEALRHYEATGKNFPLAVKLGTITPSGGGDVYSYVEDDMVHDPNLAAHLRHFGIKIDELTKTEKTMNELEVELNKNWDFDSIMEEGKNLQPISGAGYMGFVNLGNSCYMNSILQLLLAIPELKERYMSNLAPPSSVSPAKDLPTQMVKLFRAIYSDRYVHEELRPLMFRSLVGKDHVDFSSNRQQDAMEYFQHFLDLLTRAETSSPAVLNAGPISSLPSSKLFSFSFEDRLECVTSQKVKYVSREDNVLQLNIPLEAAINAQEVQEFKRQKLENSDTSQRKPVVADVPFEACLQEAFSTELIDGFYSTALGRKGPASKTIRFQTYPKYLFVQMRRYYVSEDWTPKKMDVCVTVPQTLHLGTYKSTGKQGHEVLLPDDDKSGSQGTASTNALEPDANLVADLMAMGFSENGCKRAALATSNAPAAVAMEWIFSHMEDADFNSPIPPPNATNPAPSPTTCPPEVMANLTMMGFNETQVKCALDHTNQNPDLAAEWLFSNMDTLDALVREFERKEAAKVAASSTSSQENPLESRDGGEYELVGFVSHMGSNTHSGHYVAHVKKQDQWIFFNDSKVAVSDTPPFGAGYIYLFRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJE9</accession>
    <name>A0A6G0WJE9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_014618</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000198">
        <property type="protein sequence ID" value="KAF0727359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJE9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021844"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02958">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14273">
        <property type="entry name" value="UBA_TAP-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01767">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006577">
        <property type="entry name" value="UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF6">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13899">
        <property type="entry name" value="Thioredoxin_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00594">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="2">
        <location>
            <begin position="345"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0727359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="434" mass="48038" checksum="D52D7DC177E767CB" modified="2020-08-12" version="1">MDEESLTSFMAITGADGATAQQYLEVTNWNMEEAVNLFMETGGSGTSFPSSGGNAGAAAANNSSTFDPYGGQQNVRAPDPSKRQRLVGGDADVPFPAQFFGRNSSNRFANMPNNPNGLFQRNFAEESIASLNAHLGRQDSDRRDPQSLSQLFQPPVGLIFHGSLSEARSFAKQESKWLLVNIQDETVFASLRLNRDTWSDDLVQNLVSSSFVFWQSNVKSDQGKKFCALYQIDPDVVPVTCIIDPRTGQKLVQWHDFIEKQEMAEKLSDFCCLNPLGAPTAPPPAPVPAPRERTEDEELAAAIAASLERDDDDDGYVEEMEDDDDEEIAEEKPEVFVPLPDEPADGPTVTRVQIRTTAGTRLVRRFYKGDSVSVLWQLVRQEIPEARSRPFELRTSFPPAAVPLTDQTLSDAKLENASLMMQWKPTKTCTNDFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WK17</accession>
    <name>A0A6G0WK17_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_014404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000193">
        <property type="protein sequence ID" value="KAF0727576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WK17"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009742"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037383">
        <property type="entry name" value="CCDC87"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16078">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16078:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0727576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="639" mass="73519" checksum="F0A152934DAB981E" modified="2020-08-12" version="1">MNVAAERRKHETDHATAEMRRKQIADAIMQIPTLFPWTRIDVNNTSLCHEHNSAWNQPLRDALIHEISKIYVRLMKQMNVLNAYSIIHNAANVTRLHGQLLVEVNRKIDVPTILERLKDSPSCPDAGLSFVPMAFDFANDPKPERITHTSPAAMPRASSPNAIFPSTPPAAEKTRLHHRGAVSVSSRTFHTKNAPHKPLSISKEPLFVMLPRPTATLRDLLESIIDDEEPSVTRFRDRPILAEATLDITSPLPKRNGEKRATKPRYLMRENCPALPHQHSIFDDYVVPREVWDAVQAEHGKPMDARHTFEPIEPDDIQMSCYYARACPKERDTLSSALHAMAIRREKSVARNVTDMVLDPQFAEKDNSLLLREVKTLFMTTNEAYHEFRDTLHKPMKVPELVDMAVKCALNDMSISLDGAIVSPEAMVQIPPHLTPPSLRRKQPSVTNESADRPVMTRREVMENLHDFESDRRLLALWKRYHEMCDRVNHRPFDPIPLDAIWSVRFENVWRGLLVPPTLRLDLALKYSHPDHAHRLADAVTLWEVSAIWIQERELVMDQLKKHFKNGNELRQTVLLDIKDRLISLATVTKKVKESIALTHTEVGDFVTFEEEFYLVRVHNQHRKLHDDLMALPAWREME</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WLI3</accession>
    <name>A0A6G0WLI3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Bax inhibitor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_013961</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the BI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000181">
        <property type="protein sequence ID" value="KAF0728135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WLI3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018798"/>
    <dbReference type="OrthoDB" id="1277691at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd10430">
        <property type="entry name" value="BI-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006213">
        <property type="entry name" value="Bax_inhbtr1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF32">
        <property type="entry name" value="BAX INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01243">
        <property type="entry name" value="BI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0728135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="239" mass="26280" checksum="B00EE4197706C2D2" modified="2020-08-12" version="1">MDAFMNHFTTKSFDFAALLKTNDISASVQKHLAKVYTTLAITVLVAAAGVLADMMFDLVGIISSIASFALVIALAVMDTRDVTKRLNVLMGIAFTTGVNLGPLISLALDVHPMIVVSAFLGTAVVFACFTGSAMLEKRRSYFYLYAAISSGVLCLTLLQLINIFVKSHAMYTMELYMGLLIFCGYVLVDTQMIIEKASLGDRDFVSHTLELFLDFVSLFVRVLLILLEKAKDDKEEDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WP09</accession>
    <name>A0A6G0WP09_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_013202</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Host cell</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000169">
        <property type="protein sequence ID" value="KAF0729065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WP09"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006003"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043657">
        <property type="term" value="C:host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045379">
        <property type="entry name" value="Crinkler_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20147">
        <property type="entry name" value="Crinkler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="346"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0729065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="539" mass="60656" checksum="E28BB0A115230FCB" modified="2020-08-12" version="1">MRTLFCLVVGEVEPFPVRVAANETVGDLKEKIKEETHYTRRAMDLQLYVAVKDNAWLSVDDDDLEGLSQPAEGNAWKALYVKRERKMKATNKLSKIFFVEKSEKYPAYCDDDKIHVLVVEPERVAAPLDYQPSKKRKLDDFTNAIAAPSLFAKCRGSDSWIFQLKEFDGVIECHRLPTSDERSLLPLVLLHETFATFESNCKTIAFGKPDCDFFVKFCDAVSGGHEKEETLANAALNTLGRYILSDCPRGASMVPAQVDNSTSDGSYIFDNTLLLNLQVKGQKGDGDGDPTMQNIAYYVKHLPKPIDRVLPCYLLDICGPLLSVFGIVNVTNEYALCEPLVTSIPLLFFDNVGLMTTGVRVCASLKAALRDLTSLYAFTGRDLNPSRFPYHDLAVIDGEKVKIRYCKQLERYVFCAMVVQAGHEVVVKFAKQYGREVHEYCAGHGFAPKLLYFEVLPSNWIFVVMEKLELEPILLALTDAKGDSKVNAKVDAKVIRRQVLEIKNRLAAAKLVHGDLRDANIFWDYTKDRVVLIDFDWSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WPV2</accession>
    <name>A0A6G0WPV2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_012913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000164">
        <property type="protein sequence ID" value="KAF0729412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WPV2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018338"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="79"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="156"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0729412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="411" mass="46142" checksum="A87F9AA2AC6B83C7" modified="2020-08-12" version="1">MEIHKSRLSSGSLDDLHTAAEAGLLLLEQNNSLRNQVLHLQEQVMTLQAQMARAASALELAASKYDSCWQQRCVAVQEAADVLKENRKLVADLKAANDRAIYWEREATKMENRLHHVENALQQHVQDVKQKRQSLRLSMTLPPPLPLCEEPESDNQKQTDEHLNRANAQIDALQVELAAMTSLKLNYKQVLQAKDALAMEMEQLREEQTEERELIQSMRDTISQLKQHINHLELTAAEPAIDAGGLDSPEMLAQLQKIGHALASFESNAPKPSPLEPLDVQRILDNMERLLACLKAHTPLAWARPVVRTSMTKSKTLSLPARCHEAIKCFQEAWPSASEVDFMNLTDWLHHALRGTGLDRPLSMRGVGEDDVAQVVATLVPLLQRASHRKISVAVVDHVKYTSDVILHCED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WQF4</accession>
    <name>A0A6G0WQF4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_012720</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000162">
        <property type="protein sequence ID" value="KAF0729659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WQF4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009490"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01886">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000001">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000001">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000514">
        <property type="entry name" value="Ribosome-releasing factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053905">
        <property type="entry name" value="EF-G-like_DII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43261:SF1">
        <property type="entry name" value="RIBOSOME-RELEASING FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43261">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22042">
        <property type="entry name" value="EF-G_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="32"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0729659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="733" mass="80933" checksum="2A2F296E4552CE85" modified="2020-08-12" version="1">MLQSRWRRLFVQSRAWTSFYSTAAGASTQDIDRIRNIGILAHIDAGKTTTTERMLFYSGTIKRMGEVHDGDTTMDFLPQERERGITIGSAAISFEWKNHAINLIDTPGHVDFTIEVERAVRVLDGAVAVFDGVAGVEAQTETVWEQADRYKVPRIAFVNKLDREGASFERTLSMIESRFNVTTLPIQLPMGENADFYGIVDVISMEMLQWPDAEGQTIRRLPLVDSGANETMKKLYADAVAARSSLIEKASDFDEELADLFLAEADIDADTLKAALRRITVAKPIDKPQAIVALCGSALKNKGVQPLLDAIVDCLPSPSDPSSSPFEAEATKDKSVVTLKADADGPLCVLAFKVKHDRQRGPIVFFRVYSGTLHAKAQLFNTTRQAKERLTRLLLVAADDADEVEEIRAGNIGAAVGLKNTFTGDTLVAGNAMNRLELPGVEIPAPVFTCSIESDSLSRQKELEEALQHLQREDPSFVVTEDEETGQTLMSGMGELHLEILQDRLRTEYKLSPTVGKMRVAYRETIASSTEHVFTYDTMLGSDRQFAKIAFAIHPRDVEASKDGANTIRWKKHEDKSRVKLPFAFVQAIEEGLQSGLGRGPQTGYRLAYLDIEVDAAECEFDQDSSANAFRAAAALGLREALEQAGSLQLEPVMLLEIRTPDRCVGDILSDLNSQRRAAIQEVAICPSLRVGRSRIEAHVPLAHMVGYATALRSRTQGEADFSMQFLKYMPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WRC0</accession>
    <name>A0A6G0WRC0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_012487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the dynein light chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000158">
        <property type="protein sequence ID" value="KAF0729998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WRC0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013775"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21453">
        <property type="entry name" value="DLC-like_DNAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.740.10:FF:000016">
        <property type="entry name" value="Dynein light chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886:SF2">
        <property type="entry name" value="DYNEIN AXONEMAL LIGHT CHAIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="1" id="KW-0243">Dynein</keyword>
    <keyword evidence="1" id="KW-0493">Microtubule</keyword>
    <keyword evidence="1" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0729998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="111" mass="12765" checksum="CD5D378F3D7F3D97" modified="2020-08-12" version="1">MPEPAKVDVVGSELTDAEYRKLSSRPHMKYNDMTAEVCTETIEIITMAVDKHVPLKNYEAAAQLIKQSMDKKFGAFWHCFIGEGYGFDISYQQRHMLYMYVGEIGILVYKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WRG1</accession>
    <name>A0A6G0WRG1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Membrane insertase YidC/Oxa/ALB C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_012484</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the OXA1/ALB3/YidC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000158">
        <property type="protein sequence ID" value="KAF0729995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WRG1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013778"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20069">
        <property type="entry name" value="5TM_Oxa1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="YidC/Oxa/ALB_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03592">
        <property type="entry name" value="yidC_oxa1_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428:SF65">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX18, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="OXA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Membrane insertase YidC/Oxa/ALB C-terminal" evidence="8">
        <location>
            <begin position="110"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0729995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="371" mass="40113" checksum="6CA98D0E5E50FAAA" modified="2020-08-12" version="1">MLGVATLIRARAGRAVAFSQVLRSSKAASPAGFRAFSHSPVLGNADNQTTTDISQDLGSIQQNIDVVAAHNAIDAVQAVAAPTTADLGYSLSELAIRTLDIVHATSGLPWWATIIATTVVVRAAFFPISIMSMRNSARMSILQPKLEKLQAEIKDSPDAYDPAKMADFRKRAKALFKEHKVTPFRSFLMPLSQLPIFLGFFWGLQDIAKYMPDYANDGAFWIENLAAPDPTYALPVMSSALMVASLEMGGEGMSEEYIQKAKTAMRVVAVIMIPVTMNFESGILLYWVSSNLFTLTQTLLLKIPGAKDALGIPTKPAAPAFSATKISQFPSPFQAAVAQAQKNQPFVQTYANKPSKVAKKEQTPPQTPSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WS43</accession>
    <name>A0A6G0WS43_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vacuolar protein sorting-associated protein 54 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_012254</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000155">
        <property type="protein sequence ID" value="KAF0730252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WS43"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009444"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990745">
        <property type="term" value="C:EARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019514">
        <property type="entry name" value="Syndetin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040047">
        <property type="entry name" value="VPS50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019515">
        <property type="entry name" value="VPS54_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13258">
        <property type="entry name" value="SYNDETIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13258:SF0">
        <property type="entry name" value="SYNDETIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10474">
        <property type="entry name" value="Syndetin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10475">
        <property type="entry name" value="Vps54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 54 N-terminal" evidence="6">
        <location>
            <begin position="41"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Syndetin C-terminal" evidence="5">
        <location>
            <begin position="685"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0730252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="879" mass="99758" checksum="7040D420B0FBC364" modified="2020-08-12" version="1">MQQDQDTSDKLGIQKPVSAQRETSPLIESGFSLSKEDKVLTELDPRFFTQDFDPVQYVLDNLPTNPFKMSDHLQAEIGAMDVAKDIVTSKLAEDIQRNYTTFIQGMNQVQEVDFDLALALIQVKNGRRLLASHKKDLVMSHLELVKLRRNRDRLQTIVDHASNILSCFKQEQDMFTLLQDHDYKRAVDVCIDMKDRYSDLRQFVVLRPILHRMARALPELRKHFDSSLRSLLVAFDAGHYAKLIEAYAALDKQVASSSSQKSYVPVMADVVVRGMDELAREILVALDESTKAAAPSSISSMMDTVLTAYENAAQLLYSYHLMAQWHASPSRPQVDGVDEELLNQLEQNLLKHRSLVWESLQQRMGDMWNRLAWPNDVQMEHVVGLSHATKTFLALGDEFSGAASSNKLRTVWLTKCRVFLSQMQHDSIELMRMMLDTEKWERLSIAIDDSRGILWLLEQRSGYVLTKPDHAVLPNNLLAQFTDGGNPFSPSQRKRLLDVPAMERYTFVDARKDEEDRLIERMLEMDPYLKDPSMDVSPIVDPSAEEIIRFGSKHVVTSSAFSGFLRFCGIYVKLMQQVPLLSDDAWTHLLGLFEFVFYATFCVFCPAANVTRLLARQTPTDLPSDNLRVWILKLQQLYPIAPVQGQGSPGFLELVVAFEALVFQMHVLLTAANAMSTSLDPIRIAMDEARTYVYASVTPASIQASAIPAMIEKASWDVNDMSDKHNEYVVTVVRHCGIFWGTLQGSSVPPEVRDELWGFVVRAIMEALVDGFASVKKCSMEGRALMSMDLIALQNGLDLINHVSNQSQTTMWGRSYVHNFVKAYYYQEPELLAFIAANKNRYRKVHLVSLATNGVCSSLRKPAFKDLMHQIDQIFRTDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WSE8</accession>
    <name>A0A6G0WSE8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_012106</name>
        <name evidence="11" type="ORF">Ae201684_012107</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EamA transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000154">
        <property type="protein sequence ID" value="KAF0730404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VJMJ01000154">
        <property type="protein sequence ID" value="KAF0730405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WSE8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005955"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004626">
        <property type="entry name" value="RarD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00688">
        <property type="entry name" value="rarD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911">
        <property type="entry name" value="ACYL-MALONYL CONDENSING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911:SF137">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER G2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="9">
        <location>
            <begin position="5"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0730404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0730405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="330" mass="35557" checksum="CAA0AB1E06B4D4C2" modified="2020-08-12" version="1">MSAKIGIASAATAFAIFGIYPVYFKQLPDVPPFQLACHRMLWSFVTLLPLFLSQVEWKTFRDSALQPKVLGAYFVSGIAIGGLWLLYQWGIAEGHIIEISLGFFMNPIFTVLAAVFVLKERLRVWQWVSVGLAILGVLVIAIAYGKFPWLSISIGSLLALYGFVKSTTPLTAVESVTIEMAYLFLPALAYLVACQVQGTGAFGHVSATQHVLLVLSGVVTVVPLLLFGYAAHLIPFSLLGLIQYIGPMLNFILGAGVYHEPFSTSKLIGFILVWLALATYGIEGLVVKKPSSSAAIPIATPTESDLAAKDGAETLPSTPTGDFSLVELEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WT46</accession>
    <name>A0A6G0WT46_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_012031</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000153">
        <property type="protein sequence ID" value="KAF0730612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WT46"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009646"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052346">
        <property type="entry name" value="O-mannosyl-transferase_TMTC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44227">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44227:SF3">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE TMTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="179"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="317"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0730612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="544" mass="60408" checksum="3047C6ECE0AD47D3" modified="2020-08-12" version="1">MNLVAIFGTAAAAYYVSPFMKGPWMFINTWDDSINFVENTMIQTPLSFASILDMLTVVKINVYEPLAWLLKAIVHSLAGMDSYTVRVVALSLHACNSALVYLTSLTVLNHLGTPDSTGCLLGTLLYAVHPIHVEVIGWPSAQPYALSMLFALLCLLSYLRALSSSSKMQASLFMASSTVFYIFSVLSKSVSILFPVAIFLIDVLLADKAPKLAKFHVAKLGFVVAGVLLMAKTIAANTEGTYHDADVVHLTFSQRCVKAFIVLLWPWRQFLWPAQLRYHYQVSPEDLQVFHPRGLLSIAFVAAITVGGLLRRDKAIVAAWIYSVAMLLPVSGLIPHGLVFLAADRYAYFPTLVFVPLCGAAFSTVTEPSTRRFVALLGCVWALCLAHVSVLQFESWRTAEALYRHGLHQDPTDWAMLDSLQDQLLRMGQFDEAKTYLERALRYSPTEGLKARLQIAKYLMLLQRVDDACAIYHGLLEANPSSAHVNNNVGICHWKMGKLTVARQHFVQALNGSGLTWGDKSPETNIELLDAWDPRTPIQASFMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WUB0</accession>
    <name>A0A6G0WUB0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_011593</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000147">
        <property type="protein sequence ID" value="KAF0731044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WUB0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018484"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827:SF1">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0731044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="365" mass="40724" checksum="65081433188ED5C9" modified="2020-08-12" version="1">MELSVEMEIDPHAARHSSRSSKIRLTIDASQSLLAREHQPLIQSSTQRWKLQKFCSIEEIFHATWRAIYTTLSLFTGLLGVRNKVKHSSGLFCSEKHAAFEQRTTEMWAASLLKFPHVASMTDLQLDNIALPDEELLGWTKFTDIQPLSASEYDLQHDDLPLDLLEAIFKTESVLPSPLQPIQSVTTSIHQAMSAPQSEMQVDDLPLDLLEAVFKPDTTWTASVQPRVPDIPTPRQQTARKLCEAPGCVKYARCQGMCTQHGGRRYCEEVNCPRVAQFAGKCTAHGGIKPCNVPGCQRAVQSRGRCKTHGGGVRCQVAGCTKGSISRGRCRGHGGGMRCQVDECGKWAQREGCCVRHYRELVHYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WVD2</accession>
    <name>A0A6G0WVD2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2 Aida-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_011337</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIDA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000143">
        <property type="protein sequence ID" value="KAF0731436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WVD2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003010"/>
    <dbReference type="OrthoDB" id="428576at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.360">
        <property type="entry name" value="Axin interactor, dorsalization-associated protein, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025939">
        <property type="entry name" value="Aida_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023421">
        <property type="entry name" value="AIDA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036818">
        <property type="entry name" value="AIDA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28654">
        <property type="entry name" value="AXIN INTERACTOR, DORSALIZATION-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28654:SF1">
        <property type="entry name" value="AXIN INTERACTOR, DORSALIZATION-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14186">
        <property type="entry name" value="Aida_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08910">
        <property type="entry name" value="Aida_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51911">
        <property type="entry name" value="C2_AIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 Aida-type" evidence="3">
        <location>
            <begin position="127"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0731436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="287" mass="32174" checksum="61D876283433C778" modified="2020-08-12" version="1">MQSTAKCHRKWVQLLEAAVKADGWGQVIEAVEAYEAAAAAILNDLPQVELGDDARDIVEKTIVTMNLRTTCLSSIDGAQLRPTNDEMQLVLQTFQRVLHHAPCVFPLDLAELATPTWSDAKPTAKSKKSKVAASTTDGVTIFIEKIGLKDADRYIDPQIVVSVVDKTLAVVQDKVETAVAMGRQSPYIFFETSLTLEANLDKLRQNDCTIFFEFVHYKKDKRKKSVRCWTMLEMDEIKPGPLALELYAKPCDVSKRAVHLFTVKPLYLHIELQLKSNATRQSDVVNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WVE8</accession>
    <name>A0A6G0WVE8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Hydroxymethylglutaryl-CoA synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_011155</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. HMG-CoA synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000141">
        <property type="protein sequence ID" value="KAF0731530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WVE8"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004421">
        <property type="term" value="F:hydroxymethylglutaryl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006084">
        <property type="term" value="P:acetyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00827">
        <property type="entry name" value="init_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000008">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013746">
        <property type="entry name" value="HMG_CoA_synt_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013528">
        <property type="entry name" value="HMG_CoA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010122">
        <property type="entry name" value="HMG_CoA_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01833">
        <property type="entry name" value="HMG-CoA-S_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323:SF2">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08540">
        <property type="entry name" value="HMG_CoA_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01154">
        <property type="entry name" value="HMG_CoA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase N-terminal" evidence="7">
        <location>
            <begin position="89"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase C-terminal" evidence="8">
        <location>
            <begin position="261"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-ketoacyl synthase-like N-terminal" evidence="6">
        <location>
            <begin position="582"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR610122-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR610122-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0731530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1040" mass="112742" checksum="1F9747E4E514A506" modified="2020-08-12" version="1">MLFLAILIVVSSEGLRGVLQDTFAVLATYPLLFLLFLLFGFSVAVASSYFHFQFSKRSGAEATVPLTCFDCEQQNKTNTKNVKQRRQAENVGILAMEVYIPSTFIDQADLEQYDGVGAGKYTKGLGQDKMSFTGDREDINSIALTVVKNLLEKYDIHPSQIGRLEVGTETIIDLAKSTKTYLMDLFHEHGNYDLEGVTSVNACYGGTAALFNSVAWVESKAWDGRYALVVCGDIAVYAKGPARPTSGCGAVAMLIGPNAPLVMESELRTTFSENMWDFYKPDLHSEYPTVDGKFSQSCYMKTLDDCYRRFCVKNEQAGITKNGQYFDVSVNDYVLFHSPYNKLAQKGFSRIVFNDFLRNPNSPQYQKLKPWHGASLENTYYDRDLDASARSVSLDMWNRMVEPSCFASRQIGNCYTASVYINLACLVDSLRNQLQGKRIMMYSYGSGAVGSIFSLRAVRPDSSSQPSALPGFTLERMSECLNLAARLNTRLKRTPEEFNAHLDLRESTHGVKGHTPVQAVDSLFPGTYYLIGIDDKHRRRYARKPLSASVSYSPLPVIAAVAGSPVAVTSTSDKVKPANVEVLVTGVAAGTPGTVSLGLTELLEGVNCIEPASLEAKQAMIAKNIVQLKKDKSGAIRRIPVKNLEEVVQLSAPMKPADLVGDFGLPKSLVEGMDTASASAVAAGLKALQQAGLVAGTVENGWGNWRLPDAMAASTGVLFAASFPALDSCVKEVSRSHTDPAYEFDRKLLFRLLVSANSQLAQIVGAKGPNAHVNATCAGSTVALTMAQDWIRMGKCERVVVIAGDVASNETLFPWIGSGFRSLGAASIASTVAEAALPFDTRRNGMLLGSGAIGLVLEAKPSINRTLPATPSVYLVASQMSNSAFHGASLDKEHMAQELNRFLQMVEAEHGISRATLATQGAYYSHETCTQASPTAACSFTEVYMLRSAFGDAGLESLVLVNTKAFTGHAMGVSFEEVIAVEGLKRGILPPVVNHVNHDPNLSARPLRLSQGGAYPHVKYALRFAAGFGSQIAFTLYARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WVG6</accession>
    <name>A0A6G0WVG6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_011156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000141">
        <property type="protein sequence ID" value="KAF0731531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WVG6"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0731531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="204" mass="22845" checksum="DA972CC272CFC5A0" modified="2020-08-12" version="1">MTNAEKWEAVGHPVVKQLHAALCKQEAFILATNSNTNRSGNLQPHPQLLRAVELEDLIMRKVNSWVGEKKSRDFMHDPLAMAEYSKLAKYMEAAIESTDESNRSFWQKDVASPGSAKSIMEQLFQPSWMTLPQAMSASSPDGGKDEKKSKKHKKEKKSKKSKKSKKHDSPSSETKSSSTSDTHFHPYAGNNPIGNVTRALMQME</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WX05</accession>
    <name>A0A6G0WX05_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_010677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000137">
        <property type="protein sequence ID" value="KAF0732024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WX05"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016383"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0732024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="205" mass="22806" checksum="F0ABF926D78DBA16" modified="2020-08-12" version="1">MIDRHDLIPKHSPISMNSSTALRLLPILSTTAAALVFTICTRHVRTTRLSSLRPANLIARFLDVPNQYVDVYETTLSRPTTVQEFARAFFESPVFQVERRVLKLAGAGEVTDEAIQALNFEPGDAVATFQVVENAPGEILLCWSDKETVNGHSWLALTENGTTVLFGSTIRNDSLFVRLATPLHCMYAKIVLASARYELEKSLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WXS3</accession>
    <name>A0A6G0WXS3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ER lumen protein-retaining receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_010586</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000135">
        <property type="protein sequence ID" value="KAF0732297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WXS3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000306"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046923">
        <property type="term" value="F:ER retention sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000133">
        <property type="entry name" value="ER_ret_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10585">
        <property type="entry name" value="ER LUMEN PROTEIN RETAINING RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00810">
        <property type="entry name" value="ER_lumen_recept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0732297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="32998" checksum="738D2259D7E2A8B5" modified="2020-08-12" version="1">MNMVKDKPAMAGILARHKGNIALWTGFFAFVVFSYHFFSDGDFSFLMTFGAFVRAFGFGILIFKSLTQKSVAGLSLKTLQLYAFVFFFRLCSITRYQGYLPYDRSGDWLYTFIEFLALALTAAVIFLVTVQFRGSYDFKYDTFGHLHVPSEYGIAYILVPCILLGMLIHPNLNLNWFADVSWTIALYIEAIAILPQLFMFQKRGGGTVESCISHWIYALAFGSFLHLWFWLFSYHELGEKNAGHHVGYTVIFVQIGHMLMMGDFLYYYFKSMKDGGPMMLPTHGDFQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WYF2</accession>
    <name>A0A6G0WYF2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_010416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000131">
        <property type="protein sequence ID" value="KAF0732521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WYF2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021575"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0732521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="496" mass="57335" checksum="27D62BB4D0CB5327" modified="2020-08-12" version="1">MDPETNNEDDGLELLQRARLLVQAATNLPDFSTLFSKRTDANANASNDTRHRSKPPKRSKKAISPPTNQQPERYDNKSMKDFCSEATVENLGRIKQLIICRDEQPTKRPVVKRKPKPKSPVKEPDKVESEEKKAVDALARKYAQERAAARVAAKLREKMEEARQEEQTKAECVQEFYETLEEKELRLKQDRKRAKERAKALREKLNHKPMEEPQPQRPEHNPDQIEKFQRETKERLKRAKDQKKLAEMQKQEQMMKEQEEKQAHQAEDEAAAEEARRRAEQLRRETKRRLKAMQAHKEEMERKEMELRQQGLEKYKHYKDEMERVAKGLPVSVAKPKANSVTKPSEPSPVEEDEALSHGDNDAIPDAADDVLIEPQDEENNNKMDLTTEPEEQHEVELTGHSIELPPLLPLVDTKTKKLLKKPQKKAVWQRPPVPIPTTEYIVHRSKLMPPSVAKNDSYADRMKSRSAPSSLGSQAERLASATRERAKQMDKSFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WYJ7</accession>
    <name>A0A6G0WYJ7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_010384</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000130">
        <property type="protein sequence ID" value="KAF0732677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WYJ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003262"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0732677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="135" mass="15467" checksum="51336C5A538EBF7D" modified="2020-08-12" version="1">MVVYYAKKQSLLRALKLQSADYVAMEVQSNQGLLSFLNDQTVFGLDQIVDATWSTRRTVTMRLDALDGHMVKQKLVFDCQADLFYFLVELGMEPSQENGKVRRGSFSNPQRRKSYADHIIARHSARTSRAKSDFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WZ37</accession>
    <name>A0A6G0WZ37_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_010185</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000128">
        <property type="protein sequence ID" value="KAF0732858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WZ37"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019616"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF214">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026319474" description="Protein kinase domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="451"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="573"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="513"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="308"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0732858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="851" mass="93047" checksum="C74AC65C7201B578" modified="2020-08-12" version="1">MRAAIVDAILLICFAVACVADVKKTHFEDSQFTHAVRQALAATGVASLGHMPMLETPWRRYMDAVRECASTLYNRNTRRLVFLNPSLAPSEQCTPSLNLATLNLEAAMRDFVGDDQFRDVLRSIPAAGITKDRVVDLQWPAGQSSIVVSVRGIDADASNEWTLSTNAKWILFRRPSLSFSPNGNPQSASVTVERKTRTGTFASVQQSLFNDQDWLLFAGDNSGEDWSLRFTWTRDLLSSSIADRFFILPLALPVENALDPVVARQLATDADKQAVSPSAKDPLEAVSTSTKDPLDAGNNTLPPPSTPSPTRNTTTETPVTTPSTTETTEKPPTSSPATSNPTPTNPKTSPPTQNPPPSPSPVNPPPLTTLGVTIPSPTANSVEEPPTSTETTNAPDLTMPDVSTSNPTQTKVSRSPKPPPIDGDGSGKSPNEPGGYPVVPPSTSKNEKFTMWYIIGGSGLGIVAIVATFCLWIYKHRRSATSVHDVVANEEDVQEYYMASRRDSLPRKRSRVASIEMASHNKPPLQQRRRSSGAAAPPLALPIKEDVAKREDDQLGDLDLSFLHVHRIPAADIKIIESVAVGAFGEILTARYENKLVGVKRLLPSKKHQAADVSKFLFEIKLLSTVESSYIVSFVGASWTRVSDMMLVMEWMDAGDLCTFLASKTRTTFPWRCKVQCAHDIAHALVYLHSMLPKVLHRDLKSRNVLLNTAMQTKVTDFGISRELDSYETRTLGVGTYRWMAPEVLQHGHYDTSADVYSLGVILTELDTHKMPFHDVKVKGGSAQIVTDMAIMAKVLAGEIAPQFSTTAPSWYVELGRKCMALDPTTRPTAMEVAYALKMELRNLAGEETTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WZD3</accession>
    <name>A0A6G0WZD3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">5'-3' exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_010207</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000128">
        <property type="protein sequence ID" value="KAF0732883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WZD3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018942"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033567">
        <property type="term" value="P:DNA replication, Okazaki fragment processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09859">
        <property type="entry name" value="PIN_53EXO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020046">
        <property type="entry name" value="5-3_exonucl_a-hlix_arch_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002421">
        <property type="entry name" value="5-3_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020045">
        <property type="entry name" value="DNA_polI_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038969">
        <property type="entry name" value="FEN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42646:SF2">
        <property type="entry name" value="5'-3' EXONUCLEASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42646">
        <property type="entry name" value="FLAP ENDONUCLEASE XNI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01367">
        <property type="entry name" value="5_3_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02739">
        <property type="entry name" value="5_3_exonuc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00475">
        <property type="entry name" value="53EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="5'-3' exonuclease" evidence="3">
        <location>
            <begin position="39"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0732883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="349" mass="39272" checksum="2C0B415D76C3AB63" modified="2020-08-12" version="1">MVNWLIRQRPGIPGRLRWDARCSLSTFESDASPLEARQKRELTLLVDGNNMLYEAYDPRCTVAWNNQQVGTAMRFVQRLHEILRAKNATRFAVFFDTPHVTKRQLGNAQYKPKHRKRMMPHPLRAQFPVTKSVLEQLGIPVITLQVPGVEADDLIASYTKESIDEGFDVIIVTNDTDMYQLVKTIGTGDDGTDQSVVVYQPFRGRTIPERRVIKLLHGARPDQQPEIRALCGDPRGKTPGIPGGVSTQVAIQLLKQHGNLPSLLRNLDELDDRGLAQRLKASISLIEQSYRSSVLNCAVPLPIPTEQLSISQPFQFDHNVLLQFFGRDGAEEVVALKEKTKEAKVIPSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WZZ7</accession>
    <name>A0A6G0WZZ7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Delta-1-pyrroline-5-carboxylate synthase</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="17">Glutamate 5-kinase</fullName>
                <shortName evidence="17">GK</shortName>
                <ecNumber evidence="17">2.7.2.11</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="17">Gamma-glutamyl kinase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="17">Gamma-glutamyl phosphate reductase</fullName>
                <shortName evidence="17">GPR</shortName>
                <ecNumber evidence="17">1.2.1.41</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="17">Glutamate-5-semialdehyde dehydrogenase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="17">Glutamyl-gamma-semialdehyde dehydrogenase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="20" type="ORF">Ae201684_010000</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>L-glutamate + ATP = L-glutamyl 5-phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14877"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 17">
            <text>L-glutamate 5-semialdehyde + phosphate + NADP(+) = L-glutamyl 5-phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 17">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 1/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 17">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">In the N-terminal section; belongs to the glutamate 5-kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.11" evidence="17"/>
    <dbReference type="EC" id="1.2.1.41" evidence="17"/>
    <dbReference type="EMBL" id="VJMJ01000126">
        <property type="protein sequence ID" value="KAF0733183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WZZ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012818"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00359"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004349">
        <property type="term" value="F:glutamate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004350">
        <property type="term" value="F:glutamate-5-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07079">
        <property type="entry name" value="ALDH_F18-19_ProA-GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000006">
        <property type="entry name" value="Glutamate 5-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00412">
        <property type="entry name" value="ProA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00456">
        <property type="entry name" value="ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005715">
        <property type="entry name" value="Glu_5kinase/COase_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019797">
        <property type="entry name" value="Glutamate_5-kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000965">
        <property type="entry name" value="GPR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005766">
        <property type="entry name" value="P5_carboxy_syn"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01092">
        <property type="entry name" value="P5CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001221">
        <property type="entry name" value="PRK00197.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00407">
        <property type="entry name" value="proA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01027">
        <property type="entry name" value="proB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11063:SF8">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11063">
        <property type="entry name" value="GLUTAMATE SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036429">
        <property type="entry name" value="P5C_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00902">
        <property type="entry name" value="GLUTAMATE_5_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 17" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12 17" id="KW-0521">NADP</keyword>
    <keyword evidence="9 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 17" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aspartate/glutamate/uridylate kinase" evidence="19">
        <location>
            <begin position="17"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="18">
        <location>
            <begin position="299"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR036429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF0733183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="725" mass="76864" checksum="939C401EE649F697" modified="2020-08-12" version="1">MSSSARNLSRQDFKHAKRIVIKMGTSVVSTNGEPALGRLASLVEQISMLKRQGKEVLLVTSGSIGIGRKKLHKQLLLSASLRTHVQGGTSLHQSLDAKKGAMAAAGQVGLMALYETLFSMYDVACSQVLVTEAEFKTNEHRTNLRDTILHLLEMDVLPIVNENDAISAGLHRDEDGIFTDNDSLAALIAAETEANLLILLTDVEGVYNKPPSEPQARVLSVYSDESIVFGKKSSVGRGGMQAKIQSAQRAVHRGVNAVVIASGFKYGILDTVIRGTTIGTLFVPDPSTLLPTHSPEDMAVAARDGSRVLLQLSSKERSAIVQRLARSLVEQSERILAANQLDLEAAGSLDPQLVSRLKLTQAKLETLAQGIASVANQEEPVGKVVSLTEVSKGLVLEQVTTPIGVILVVFESRPDSLPQIAALALRSGNGLILKGGKEARHSNACLHSLVQAAIREETKGRVPESVIGLVTSRDDVGALLALDHVIDLCIPRGSNSLVTHIKKNTKIPVLGHAEGVCHMYIHAKADIAKAARLAVDAKTDYPAACNALETLVLDEEVVVSGAHSSILSALADAGVTLHVGPEAARRQLIPHAPAAPSLSHEYGSLGLTVEVVSGGVDGAINHINLHSSGHTECIVTEDAAVAETFLARVDSACVFHNASTRFADGYRFGLGAEVGISTGRIHARGPVGVQGLLTTKWKLRSASDHTVAAFSSGEAKYTHKTLSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X055</accession>
    <name>A0A6G0X055_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ribonuclease</fullName>
            <ecNumber evidence="13">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Ae201684_009983</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 13">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12 13">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 13">Belongs to the RNase HII family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="13"/>
    <dbReference type="EMBL" id="VJMJ01000126">
        <property type="protein sequence ID" value="KAF0733164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X055"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020517"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07182">
        <property type="entry name" value="RNase_HII_bacteria_HII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000006">
        <property type="entry name" value="Ribonuclease HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00052_B">
        <property type="entry name" value="RNase_HII_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022898">
        <property type="entry name" value="RNase_HII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000594">
        <property type="entry name" value="PRK00015.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000595">
        <property type="entry name" value="PRK00015.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF23">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51975">
        <property type="entry name" value="RNASE_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 12 13" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10 12 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 12 13" id="KW-0540">Nuclease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-2" evidence="15">
        <location>
            <begin position="80"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="39"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF0733164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="264" mass="28591" checksum="9C903FB795112333" modified="2020-08-12" version="1">MGTRQVMPLRRSARLMGSSATLAPPAPAVKKAKAKIDRAPKKANATTAVSKKNPGNGDKGFKHGTLSRDIEQRIYDKGFTRVVGVDEAGRGPLAGPVVAAACFIPLDVTIEGIYDSKQLNEAQREALFEQLTTHKGIQYAVHVNSPQRIDEINILQATMESMCEAVNGLGVAADYALIDGNKMPPLDIPGEFVVKGDSKVFAIAAASIIAKVTRDRLMVAYDKQYPEYNFAQHKGYGTRAHMSAIHKHGASPIHRMTFAPLNQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X069</accession>
    <name>A0A6G0X069_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_010003</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000126">
        <property type="protein sequence ID" value="KAF0733186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X069"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012816"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030308">
        <property type="term" value="P:negative regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042496">
        <property type="entry name" value="CGRF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002487">
        <property type="entry name" value="TF_Kbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15379">
        <property type="entry name" value="CELL GROWTH REGULATOR WITH RING FINGER DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15379:SF2">
        <property type="entry name" value="CELL GROWTH REGULATOR WITH RING FINGER DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01486">
        <property type="entry name" value="K-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="263"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="76"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="122"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0733186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="310" mass="35856" checksum="69AD8B40681466D6" modified="2020-08-12" version="1">MGNNLPPAVDEVSDDDSDFFIDHNDITLSFDEETSEGPSEDETVVRMLELAVPRPVQSSLTQLLPMLAPEHQRWYSSRGDVSRSCSSSRHKTRSRAKSMPILDSQGKECGEPESEPLPSLPLEESLRRNMQLSQEVKRLSMSREVMSMQLLRAHHHAEDQSRIIEREMERSRKLERKLELFSERYRLANEGMAMVKQKLNSMRVDFHQAMTKNKNLQGEGIYSDMTVDDLEALEKTLEYGLSRVRTELRQQYRRAIDSERETCIICLHERVSIVVMPCRHRVLCATCAVRIQMCPVDRQEITDMFPTFGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X1B6</accession>
    <name>A0A6G0X1B6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase Tc1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_009492</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000120">
        <property type="protein sequence ID" value="KAF0733647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X1B6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019478"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169:SF2">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0733647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="337" mass="38137" checksum="2BF0BAAB252536DF" modified="2020-08-12" version="1">MPEASGISTGTLARYLKLGTLQRKSSRLKPLLNDQNKRQRLWFCCSHVDRSAHAGAQQEFDFFDMFDVVHLDEKWFNADKDRRKVYLTKDEAPEVRRCKSKRFIPKVMFLAAVARPRWDNARSCFFDGKIGMWPFVVQVPAARGSRNRPAGTMVTKVCNVTAEAYRDFVVNKVIPAVKSEMPSTSKCVVLQHDNATPHRSVDDAVLSPCCTDGWTFRVSCQPPNSPDLNVLDLGFFASIQALQYKVSSRSVDDVIRATLIAFETLSSEKLSDIFLTLQAVMRLVIEHQGSNQFKLPHLGKNSIRRTRTLMKNVTCPAQLVHTALAQLQYHAAEFQDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X2G4</accession>
    <name>A0A6G0X2G4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_009259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000118">
        <property type="protein sequence ID" value="KAF0734090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X2G4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004338"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0734090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="98" mass="10805" checksum="4CB1A850B6D21AFA" modified="2020-08-12" version="1">MKERETGCICDFRLDKASQEARMVGFGRKKGKSLLGDSAGKIDGSSLLDGNGDPTMATLYDNNGDKKVKRVVDNPEDEDPDAAAKKPSRSWFRLGRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X3J2</accession>
    <name>A0A6G0X3J2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">No apical meristem-associated C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_008878</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000114">
        <property type="protein sequence ID" value="KAF0734418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X3J2"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029466">
        <property type="entry name" value="NAM-associated_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14303">
        <property type="entry name" value="NAM-associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="No apical meristem-associated C-terminal" evidence="2">
        <location>
            <begin position="10"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0734418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="176" mass="19935" checksum="67AC9D13093263D7" modified="2020-08-12" version="1">MALYAGVGKKAFRFQHCHKILHGHPKWGAWRAALPTTAAGKKRKQSLLSSESSFDNNVDGDAQSDKQNGKSMDISPNDVAIHGYGQKKAKDERQKNTLLARKVEAAEQIAKNGQARTRTLREQLQVQRDNFELAIFTTKVDESESDLAFYLEKKKRIILKRLETEEKEISHDESVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X3T1</accession>
    <name>A0A6G0X3T1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_008755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000110">
        <property type="protein sequence ID" value="KAF0734599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X3T1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018608"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010393">
        <property type="entry name" value="DUF991_YecM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37519">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37519:SF1">
        <property type="entry name" value="DIHYDROXYBIPHENYL DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06185">
        <property type="entry name" value="YecM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0734599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="185" mass="20824" checksum="D1C4BF3B4DE02C5A" modified="2020-08-12" version="1">MTQGNPWTTDSFAEYLKTKGPDFVALVLEKLQTTSLKFELDWTIDHLCYRCDSMDEYNHLTKTVLPHLGHLLVESLIGGRPIACFKLSTPIALPHRPNALVDVLEVPSPKPGSHYDSGLEHFEMVVPYNLDDFLSHQADDVVFDLKAMSKSLNRDARIAVGEFSVKFHEQTLESVIAYEIAHGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X5P1</accession>
    <name>A0A6G0X5P1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transmembrane protein 198</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_008336</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM198 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000101">
        <property type="protein sequence ID" value="KAF0735124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X5P1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001015"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025256">
        <property type="entry name" value="TM7S3/TM198-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040236">
        <property type="entry name" value="TMEM198"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31247:SF5">
        <property type="entry name" value="DUF4203 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31247">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 198 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13886">
        <property type="entry name" value="TM7S3_TM198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026358006" description="Transmembrane protein 198" evidence="8">
        <location>
            <begin position="19"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="TM7S3/TM198-like" evidence="9">
        <location>
            <begin position="79"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0735124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="329" mass="35886" checksum="64F5484AA20980EB" modified="2020-08-12" version="1">MQDTCVLMVLLTVVPVLASNGNETALINMVTNLVVNVAKTMATNATLAPANRIPHADSGLLASTGVTQIAVWPALVAGACIGLGLVVTFYGYKLFRATVFGSSFAFGAIVGYMVAERVCNVDASYFYAICWGVFAVCGLITGFLGLYVLRIGVALVGMTGGIVFAFLMTTSFGYKWWPTYPDGILFILMASFGLIFAIVCYALEKPMLIPMMSLTGAGAAVWGIGYFAGGYASADDLSVYRTSDSTYHIPSSFWGYLSATIVLFIVGMLVQFLSTACCENNDLYTWETHADIEMTTHRSYFRRGSRYDDNYVRTRDNYYHAHNHRVGPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X873</accession>
    <name>A0A6G0X873_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_007290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X873"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002310"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19076">
        <property type="entry name" value="AKR_AKR13A_13D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF40">
        <property type="entry name" value="ALDO-KETO REDUCTASE YAKC [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="28"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0736268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="344" mass="37920" checksum="12DD0022C2756433" modified="2020-08-12" version="1">MAQVPQRPLGSQGLVCSAQGLGCMGMTMAYDKVDHIAQEEESLRTISKALELGINMLDTAWVYQSPRAGGDRIFYNEELVGKAIQQHGRDKFVIATKFGVVFKDGKMVVSGKEETIRSQLADSLKRLGTNYIDLYYMHRMDPTTPIEGTVALLKSLVEEGTIKYIGLSECTPDELRRAHAIHPITAIQMEWSLQTRDLEEAVVPTARELGVGIVAYSPLSRGFLTDINAFDKLEDNDRRRTLPRFNQEKLAESKAKVARFFELAKEKNVTPAQLALGWVHAQGNDVFPIPGTKSSTRIVENAGAALVSLSPEEWNEVADAAAAINADRHSPTSAAANFNTRMNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X9D0</accession>
    <name>A0A6G0X9D0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Plastocyanin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_007120</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000088">
        <property type="protein sequence ID" value="KAF0736670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X9D0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004067"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48267:SF1">
        <property type="entry name" value="BILIRUBIN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48267">
        <property type="entry name" value="CUPREDOXIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026207547" description="Plastocyanin-like domain-containing protein" evidence="7">
        <location>
            <begin position="20"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="568"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="604"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="669"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="815"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="847"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="878"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="137"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="430"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0736670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="901" mass="97479" checksum="F835837E2D4F9450" modified="2020-08-12" version="1">MAKALTILAVAGALATAQTDPPKVTSGEKLYDQWKPYTTPLVIPDVIDMRKGGGLEMNIGETVHDWGSGAPTVTTYGYGKAGGNITYPGPTILVKKDVPITVQWNNVIKSNQHILDASVENTLTIMESSCYPNCGVPVITHVHGLETPAAFDGLPHYSIYRNQSYTGRYNNTQSGATKVYHDHSIGLARLNMWSGLVGLYIIQDDETEAKYKLSNLTDIPLIFQDKHIAPNGALFYSSVATCQTPGTKWVSEAFGSINTVNGVVMPYLEVPASQVRLRMANLANARNYNITLPFADKCQLIATDGGFVGKPMPVDPTGFKMYSLERVEVVCDFSSFAVGTTFDLVDTSDADSSYDYEPRMMQFRVVAAKNTTKVELPTKMTPYKDLQALYKSTGGKLRTLTLGEMEDSMQCPTQLMIVHHQVVANVSLIQNKLTCTLGKVEKWQFKNPTDDPHPFHWHLVTAQCGPDDNSINKNELKDVVVIPNEPLSTNVLQVCYVACTPDQFLIEDTNVGPTDYGFSTDDPYLAHCHIMEHEENSMMSWFQLTKEDDALPIDDGVVLTDKDKVTSAVVWCAMGMSVLGGFATCLSVLVLSIKRLNFLAGDKALGVTFALSAGVMIFISLVDLFMEAIEKFNGVYAVGGTVDLEAIEHGLAPAGAVAPVCDKTCQGNAYLSVVACFFGGVLIIVALEFVIHRVFDFHAKRLGAQLAAAQQQPDIDVEVKTPADGAYDEVGSSEAEALTEKSEEEHKTELGRAGVLTGIAIAIHNFPEGLALFVASLQGLRAGIVLAVGIILHNFPEGVAIAAPVYYATKSYKQALFWTSLSGISQPLGALIGYATISNGADNTTTGILYAMVAGMLVCIAVKELLPGAFKFGSKQFTASFFAGFFIMAVSVVLLKYMGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X9J9</accession>
    <name>A0A6G0X9J9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutamine cyclotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_007125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000088">
        <property type="protein sequence ID" value="KAF0736676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X9J9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016927"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016603">
        <property type="term" value="F:glutaminyl-peptide cyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007788">
        <property type="entry name" value="QCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31270">
        <property type="entry name" value="GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31270:SF1">
        <property type="entry name" value="GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05096">
        <property type="entry name" value="Glu_cyclase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026271552" description="Glutamine cyclotransferase" evidence="1">
        <location>
            <begin position="21"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0736676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="31999" checksum="2A138E35D4DB9D23" modified="2020-08-12" version="1">MVRSCLTVLAIFLSFPASNAANVDALEINPLSPTHGQYDLISVLPHNPEFFTEGLLFHNGMMLESTGLEGASYVREIGPEMNITKEFTFPSGLFGEGITVLNNKIYALTYKAKTGFVLDRDTFDLIDKFNFETTTGEGWGMTTDGHSLIVSDGSSWILYFDPATMQVQRKIQVLLNDEEVRNVNELEYINGELLANVWFTNNVLRIDPNTGRVKEVLNLDHLRNLEHHAKTMRGPLKRDAVMNGIAYNPENRHVYVTGKLWDSMFELDLNVPRHHIRRRSQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X9Q9</accession>
    <name>A0A6G0X9Q9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_007182</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000088">
        <property type="protein sequence ID" value="KAF0736736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X9Q9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010825"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="130"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="331"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="56"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="167"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="277"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="420"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0736736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="434" mass="49223" checksum="EFC90A734876AB2C" modified="2020-08-12" version="1">MSDEFHTDLDCYSDMQATHNTSGDDDELRMAARAGLILLEKNTALQVDLEDLSSKIHHYEIQQQALSMEVESLRKQRSGAVMEVQAANKEIKTLQLQLHQQQAAWRSTEKSLLAQIQSLTLELHGLKTKPQVACNPPQEIKSRKPDNKEEGNQSDEHESQRGDDPRLALLRQENSELQVQLQQASRDIRQREAKWSKSTLSSNQRIQALEHDLLKLSRENKMIKQEQAEERELLESLRTMMSAYKNMMDANPQATTSDSVHFVDNNNDGGVSGDSMHEDVLRTNATLQGRIKELENIVEKISRTPLEWNADTVPCAVLNNTKHRLISVLTSKKHEQTREIPPSEETNTPQDAFPIPIRSSNDKTATDDLVEDARTRPRCVAAASVWVLLVSWVVSLMGLQATSCRRAVDWVPQGKRDEHHDEEDTTDIEDSSWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X9Y5</accession>
    <name>A0A6G0X9Y5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_007035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000087">
        <property type="protein sequence ID" value="KAF0736881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X9Y5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017818"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF109">
        <property type="entry name" value="RIBOSOMAL LYSINE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0736881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="263" mass="28781" checksum="F557E50E0C894BC1" modified="2020-08-12" version="1">MSSNSQPPPLPPPPPPPPPRSVRFAYSDEVIPPSPSSNSEEQRSERPHLPATLPRESGNGLLGLKLRSFGSLMIAQNYERMQGTGSAVWQAAEAMLQMVKLPAYMSMLHGRMVLELGAGTGINSLAAAMLNSNVVATDGDPDALALIQENIKANQFQLPKPVSVRPLVWGNQEQIQALKTEFGLFDVILGSDILFEAIEGQLLVTIYELCAMQGVVILTHTPREPSRENMLLKSFSTYFTMNESIVSGTNVVCTVLTRKVRYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XA60</accession>
    <name>A0A6G0XA60_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Adenylate kinase active site lid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_006804</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the adenylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000085">
        <property type="protein sequence ID" value="KAF0736993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XA60"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015643"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036193">
        <property type="entry name" value="ADK_active_lid_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57774">
        <property type="entry name" value="Microbial and mitochondrial ADK, insert 'zinc finger' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="6">
        <location>
            <begin position="144"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0736993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="245" mass="27156" checksum="612A1763B8CFFE7C" modified="2020-08-12" version="1">MNHSCISCTTAKSKMKKAIHEHARMMFLGPPGVGKGTYATRIAPKLNIPTISTGDLVRAEIKRDSALGKQIKEFSSTGKLVPDEIILTMVRARLQEQDAQRGYILDGFPRNVSQAIEFDKIDTLDLVVNFELPEWVLLEKISGRRMCSSCGTGFNVANINQGEYVMPPLLPKVDGVCDKCGGTHLIQRPDDAVDVVRHRLKVYDDETAPLISYYEEKGVLKNFHVTKGLADLDRLMIVLGIGSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XAA0</accession>
    <name>A0A6G0XAA0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_006843</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000085">
        <property type="protein sequence ID" value="KAF0737033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XAA0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001894"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="803"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="116"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0737033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="926" mass="105140" checksum="51F3EA22C5371CCF" modified="2020-08-12" version="1">MEGNRNEEDAAPASTPKRPVLRRHSTTKHLPSTDEAHLGWNDDENRRTRQLETSKEEFVLEFYNPHVMSNGNPSTQPSLVNTMRKTQLLLDRIGSPNRERRPSVLSFVDPLQGMTRQELKRSNLLRPVQQLPSSPSSPSKKQNRGETQRCRQCNSAHIVLVPVCKYCKKLDVLGSDMTALKRFGYSLLDKNPPILPSQLIDELVAYLHEHPMTSKSTPSLTKGQPAAVETKSVVSIDEVSRLVDESHQPIKLSSREALLELKQFRSKPSGHATLSHATKATLVRCILHAFAQSLGESVVWSKEERWDHQDLCLEMLKTLSMDDVSDIMRAYNAWKHVDEIAKMHQYDNDEAQVLWGRSTLPATPSSNSIVSSNGADQVVPDVHSFQLLRRKAIRSSVSPEKIRKMIEQKTTTSPWSFNASPTRSSEKADEEVSLLHERHEAEQEEQFKLVLLNAERFKTISSDGMFSLDNTTFLMQSLASRDLATVLLYDKQTQEMFLLGDEAERESLLHLSAIGRVDAVSAWIAKTIDCRNLLIAATTAKGQLLSSDERRLLLALDDEDARYHLQLWKHWQHLPAGTLPVPNLAFLQLNTMGRRRADREELFRVPRLWLKVVKVRDNSIQPMPLKLIRPLLLTIYLAAFKQRVDSCDFVEFVLAHIALTYGGQLKPRLQGFITALEQYYIKDTWIFAFCRFCGIADSLPSDCFMFYLSAVQSLQFAVPNRSQVADYFIPTDLFHPLFIKKAVMALRAIGTDANIDEAKWFGALQECRVVCPRRGAVGRPLYVVGLAAFMEVVLDMWLANRKAMEDEMRRLFKQFDTDKSQSLSYDEFKAFIVHCTKDLKGKVHVVDEKHIVKLYGKCLMHSDESEITIDSFVLGGLDNPMIMAMCGFSVPPTKTSAVDIVALQLIMRAMRAYIKRTRRAKTTNDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XAN9</accession>
    <name>A0A6G0XAN9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNase NYN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_006802</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000085">
        <property type="protein sequence ID" value="KAF0736991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XAN9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015641"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021869">
        <property type="entry name" value="RNase_Zc3h12_NYN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11977">
        <property type="entry name" value="RNase_Zc3h12a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="360"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="RNase NYN" evidence="3">
        <location>
            <begin position="7"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0736991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="386" mass="43025" checksum="B2E57ABCBF03B0D9" modified="2020-08-12" version="1">MKDHAPVVVLDAANIATIVRGAVRIQRLLSAFHHFEELGIRCIAFAPGYWIKTKAATPRTARALSSAEMELDQKFEMSLVQQLVQAEKVVLTPPQAHDDLFIIDYAMKHNGFVVTNDMFRDHVATKMNFHKKELTEAWVKTYCITFTFVGTEFLPSAQHIHALLKPPPKETKEPNQSAKSKGNIAAQSFKSTEPMKKSPLLTIKTSSNHSFDDDSRIEQQVANSTKAQAEPVASPRKAQRARPSTPHAPSRRSKRGNSYKTLEDCGSSSTSNSSDDESNQTKQKNVLADWQTLQQAIAQHRVSNNQDGDEEHPSTQPKEPPEVESNNDVKAPLSPTQKKRLRRRMMAPQKKPTMVYRGKYALVAIGAPLILGLVLKMVLSAATLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XD11</accession>
    <name>A0A6G0XD11_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_006079</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0738090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XD11"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004069"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040283">
        <property type="entry name" value="DDB_G0292058-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31414">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN DDB_G0292058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31414:SF18">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026338775" evidence="2">
        <location>
            <begin position="19"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="430"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="486"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="785"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0738090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="828" mass="88856" checksum="DAC0AB2648B076A1" modified="2020-08-12" version="1">MRRFALVCLLATASLCVADLDGHAVAVSQGALRTLQKIRGGTPQFYSKLFTSLQIYLCDQLNHRLQPGFADAKNAVWDSQDATVPPYIRFVRRDHPNALKDGNGTCIQAPHAAQDVLDKYAAGYCEVQPNCYWTDPRNVTAADADRTPFYSKEQATPPTSSLTVSAATSELYDWARAIALCIAPAIALAVVSLLSILIYLSCRYCCNRCGGRHPSPRVYSFRQKSIPIGLFVLFGIAIAALSIVALVYNKVIVSSVDGTFDDVLNLVNGTKSWLQAAEEPLVHVRDTVDGSVDLIAADLANSTFVEEGLNGFVTRLDAFAAKSANVVLPTGCDGSKDVICIACDVCTTINSQTTAAKDQMQSIAAQGIDQLATARQTVLSTLVDANATIQSSVNDGVNMLDAFGSPIASVEESITDVQTTWKEQTLVRRAAIVALFALALVIVVLGLVGIFFGLTIRCRPLVFILHFAYAFGTTESFYGHELSRSVGILAIVLLFIVSAVFLALSVLMTDVCHLSDYVAADWTPLLGGIGGAAINACFRNDSLVHALQLDDAFAFAHEISIPHSTNLLSMLDFSALDIFAAQILAANETTFPELSSLTNSSLGALNVYTSAEALSRTFPPDQVAQCAIHDGQYELSSIKTPWMANHDAAPDSSTSPSSYMASRYKPYRSGCSSVPISTCARRVACPYDLFVTELYSNTSTLVDVSKDAAAFVSTMHSNMKELQMYASTFKTNVTALVAALDDVGDTLASSLLKDVDAFQAHMTCTFVATDFHALQASVCDNLTPAILMVAICLFFGGICMLLVVVALLLLVQRLSSPPPPSLSILKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XD24</accession>
    <name>A0A6G0XD24_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_006006</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0738012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XD24"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009892"/>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010402">
        <property type="entry name" value="CCT_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045281">
        <property type="entry name" value="CONSTANS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31319">
        <property type="entry name" value="ZINC FINGER PROTEIN CONSTANS-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31319:SF77">
        <property type="entry name" value="ZINC FINGER PROTEIN CONSTANS-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06203">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51017">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCT" evidence="4">
        <location>
            <begin position="150"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0738012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="205" mass="23357" checksum="A9D66AA04FDECA5E" modified="2020-08-12" version="1">MLLLHAVDAVDNIDIAETLITLTKAEYVHGSPATSGDESPAAGSSDESEQDDTSSLIRLTRLAQEEFKFMKSPTGVDESWTIASVSKMEQGMKRMKVEELSLDGHYSHPDDEYTDHDDDRVRKMSVSSWSSNDSEATTTKKIGSYSPEDRAERIQRYLEKRKHRTWGRKINYGVRKNFADSRLRVKGRFVKKEDEELLCLYLSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XEB4</accession>
    <name>A0A6G0XEB4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_005793</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000076">
        <property type="protein sequence ID" value="KAF0738356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XEB4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015372"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039663">
        <property type="entry name" value="AIP/AIPL1/TTC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11242">
        <property type="entry name" value="ARYL HYDROCARBON RECEPTOR INTERACTING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11242:SF0">
        <property type="entry name" value="TPR_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="603"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="197"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0738356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="633" mass="69013" checksum="0A0D66AEC2CFA513" modified="2020-08-12" version="1">MLGSSVTWEKVSHLSVQDEVQMQILNEQGALTDAKQLTKRNAQGIDLDQGRNAAGVLRITLLSAEDLNLDGILDLAAQTRVVGTLSIASTAIEKAKTNIRQGKTDPTPVDSVTKRCFWNKDANSTVTFTSIKTKSPSATLTLHHPSPLVADVFIGTCKIDVTDDLLDQQEKSVWIPLSGPPGHTNPNTFYGRVHVSVRFEYDLVARLERRVVELEAKKARIDADARVFQQTAPLVNSEVRHPAAFGQAALSAGLYIPGHRFNPSQFHPAAVARTPLADGTKVVTPFGRGTVVTFREATRMYVVLMEASPGQTKRTTTAYLREDCVEDEPELPRLRPGVAVTTPYGPGEIVEVRRDVIVVKSSFGIMYMQPSDVTMAEGITAKNMTNKERIDAAVTNSTEGNASFKADALDDAISSYLTSLEFLKFVDQDTATHKEKAIVLQTMIRCHLNLAACKLKLGAHADAWTACTNAISIIQAIADARTGKVAAWMGRLGMTESQIFNEWPSKARFRRATALLAMGNDAEAKQDLMVAVKLMPKDKACRQLLETVTKRMALEKEKEKLRWGGFLVNEGNTKTTKQESKKQVVAQSTKGAKAIVPKKDGSWYQNTTVVAAVSVAVAGAAVLLLSGLSKRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XED0</accession>
    <name>A0A6G0XED0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_005651</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000073">
        <property type="protein sequence ID" value="KAF0738539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XED0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016382"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827:SF1">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0738539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="189" mass="21325" checksum="65D522A2EC299C09" modified="2020-08-12" version="1">MSQQRCMFTECPHFAIEGSTKCMMHRNRTKCEEPNCPNQAYARGRCVRHGAKKNCAISKCQYNRRFGRYCSKHADETQKKRCDVQGCEKQPHARGRCVRHGGGRHCQAEGCRRHARVGVFCTKHVSNETNQVPVGAPQTNPDWLDWAILKELILEYKEEASAAAGATESELVVPPVDHQAALNTVCVWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XEV2</accession>
    <name>A0A6G0XEV2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4219 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_005532</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000071">
        <property type="protein sequence ID" value="KAF0738604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XEV2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005851"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0738604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="150" mass="16549" checksum="CD52753E9243E478" modified="2020-08-12" version="1">MSSKNFDGNNFHYWMKAIRNHLKAARLWEVVIGTEVRPAAAHLAAQWDHLDHLAVAILMDSIRDNLLLGITGEETAAMIWAFITSKYHDVKWGTSASFLGKLTALKMTNGSNVNDHLTAFKELSEKLNVMGEGLNSSQLTALLLGSLPDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XF32</accession>
    <name>A0A6G0XF32_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">AGC protein kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_005475</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000070">
        <property type="protein sequence ID" value="KAF0738866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XF32"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003274"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05123">
        <property type="entry name" value="STKc_AGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000008">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000537">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045270">
        <property type="entry name" value="STKc_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PX" evidence="11">
        <location>
            <begin position="162"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="303"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="12">
        <location>
            <begin position="560"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0738866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="636" mass="71908" checksum="2EE8E153403BA034" modified="2020-08-12" version="1">MPTGSSSGSNESSGMSEDSYDAYNKFDMGEDLMEGYLVKDLDSGRSYRVEEIDQHYSLMTLDSAKDKLSQTEDLLSIYSADATTEVEIELPVANEDVEDDPSVEATKEVKGRTTKLVPCAFAKCTTQHTRASGYCPVHEVQAKEEEDSRAQALYLIPAGKEANFVQMKGHAFVEDAMSRLYTVYIIEMTCGEHKWCVYRRYRDFTALYDQLKVKKVGFKLPTLPPKKIIGSFDPDFISKRQTDLGVWIQALLTQEPSAVPPQTCEDVIRFLTWKADQPPFLVEQPSAFLNSNANEPRVTLQDFKMIQVIGRGSFGKVVLVGHHATKKLYAMKMLNKANIVKRKQVEHTRTERRVLGYTKHPFIVGLHYAFQTPQRLYFVLDYCPGGELFYHLTRMKKLPEHMACYYAAEITLALEHLHSLGVVYRDLKPENILLTKEGHVKLADFGLAKEGITDGVNGTNSLCGTPEYLPPEILDRLGHGTAVDWWNLGMVLYEMLTGLPPWYTNDRQKLFDRLRSARLHFPPYVSRKAENLIRLLLNRNPAERLGARGAADVKAHPFFDSIDWTALLALKMPPPFRPCRTTAPEETPLNFEAEFTRLPLPSVELIEKGARDRSTSDTFSGFAYECPDVLDQVGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XFS3</accession>
    <name>A0A6G0XFS3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_005224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000067">
        <property type="protein sequence ID" value="KAF0739041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XFS3"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0739041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="123" mass="13290" checksum="884C4140CC01B6B5" modified="2020-08-12" version="1">MTSTAFPNVALMRPPIVSPQCSASDSVASPSRLASGIMARKLSTKIGTSPHLPKYDHAATGMKKRKRLSTSIDLTVDTSDARRVASMSFGNVWLDPRRNFCASCVRAAISYEVVESVIRTSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XFV5</accession>
    <name>A0A6G0XFV5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_005301</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000068">
        <property type="protein sequence ID" value="KAF0738930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XFV5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014624"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="123"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0738930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="276" mass="32298" checksum="07066358D9C27450" modified="2020-08-12" version="1">MTSEAFFLHGCQLTRHPPNGSLVVRMRRFREMFGTSPKCCHQVWELSRTTQPSNTTPTHLLWALMFFNSYSTESEYHALTGADEKTFRKWCWTWVNMISELDCINWDNRFDNAHPEATLFVSLDGTDFRIREPSEFDPCWYSHKFHGPGLRYEIGICIATGWIVWAHGGVPCGSWPDLRLARDAFCSFVGPNEMTLADRGYCDPRYFIYPRPGRDDVRRQKEVMARHETCNRRLKQFRVLGGVFRHQLYLHPICFHAVVNLTQLMIELGEELYSVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XHN6</accession>
    <name>A0A6G0XHN6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_004604</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000060">
        <property type="protein sequence ID" value="KAF0739830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XHN6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014241"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000005">
        <property type="entry name" value="Mitochondrial phosphate carrier protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="48"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="145"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="249"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0739830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="342" mass="36556" checksum="438B1BE6EFC49E20" modified="2020-08-12" version="1">MTFVASLNAPAPIAGFSPLSKARRVPLATSTGKAWDARYSHPVPHDASYYAKCMVGGIISCGLTHTLITPLDVVKCNMQVTPGKYSGLVQGLKLVAAEEGTSALFKGWAPTAIGYSAQGFCKFGFYEIFKDFYSNLAGEEASYEYRGAIYLAGSASAEFFADIALCPMEMVKVKVQTSAAGTFPTEFGPALAAMKANAAETRYPFGSVVPLWSRQIPYTMAKFFFFEKVVEAFYTNVFTAPKDTYPKTTQLGITFASGYIAGVICAIVSHPADSLVSLMGKVENKGKSMGQIASETGVANLATKGLGTRIIMIGTLTGLQWWIYDTFKSVMGMGTTGGAVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XHU2</accession>
    <name>A0A6G0XHU2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_004609</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000060">
        <property type="protein sequence ID" value="KAF0739835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XHU2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021350"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="100"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="46"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0739835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="415" mass="44451" checksum="9B4801E8585568ED" modified="2020-08-12" version="1">MFCKYSCPQHTPSLIACVDLQNKGDPNEMEKALKTLIALTGTGVNFGKNRPNPSQAKPNYQGRANMAHGGRGGGRGGGRGGRNGGRGGGNTGRDMTNVTCYKCHKTGHYARSCTSTKQGGAAVAAAEPGNANLAAAPTLPESDEELETGSVWYAGQSEPNGKWLIDSGCSHHMVTSKNILHSPQPSRMDIVTANKVKVESKYKGSVMLHLMEGKKWGLGMARHVPDFDANLVSVTQLTQEGKKVTFEGTTCEISQNGKVLATAKLVGRLWEVDCVPYKWDGDERGDARPANSTIGSANVAHKSADTLQGWHERLGHLHKQAIVTMANQRAPSEMTITRIANDLKVPCLGCALGKHTRSEQSKDYTSQSAPSEEIGSVVCMDLKGKIKPRDRLGNQYLAAFVDHASGFTAAVPIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XI18</accession>
    <name>A0A6G0XI18_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">U6 snRNA-associated Sm-like protein LSm4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LSM4</name>
        <name evidence="12" type="ORF">Ae201684_004580</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000058">
        <property type="protein sequence ID" value="KAF0739879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XI18"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011871"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01723">
        <property type="entry name" value="LSm4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034101">
        <property type="entry name" value="Lsm4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="69"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="104"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="134"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0739879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="147" mass="15601" checksum="21E89FBDF456FF1B" modified="2020-08-12" version="1">MLVELKNGDTYNGQLVNCDTWMNINLKEVICTSKDGDRFWKLPECYIRGNTIKYIRIPDEILDMVVEEDLSKKDRNAMRGRGRGGRGGIGSRGDGGRGRGGRGGRGDGGGRGEGGRGRGEGGRGRGGRGDSGRGGRGSTRGGRGQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XKJ8</accession>
    <name>A0A6G0XKJ8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_003756</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000042">
        <property type="protein sequence ID" value="KAF0740866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XKJ8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000247"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033565">
        <property type="term" value="C:ESCRT-0 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15760">
        <property type="entry name" value="FYVE_scVPS27p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47794">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47794:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="7">
        <location>
            <begin position="7"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="140"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="284"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0740866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="417" mass="46307" checksum="9F05ABAEEC294865" modified="2020-08-12" version="1">MEACRPWEYASACRTCSRPFGLFNPRHHCRLCGVSVCGAHSKNKTVLPHKSTQKEPQRVCDTCHKNVSESLTRKRGTRRIASQRLASSHQFPWEKLRQGHSFSQRSTGTSLTLSTFKRGHEKCLDSSTSTAYMSSIAMTTLDSPSEKSTQGSLYESPSPRSSDIDVAPSSYSPVSDIAKHANGGSSPLWRLSVIDDDAAKLSMISDEALTSIDDDDEEDDDKGSAASDEELNDIEESLNLSVLSAVPKLSEYDVDEIRAGSMRNPAAVSASRRKEKLALAHGGIDHLVKVKQGLEEEIQELEIQLSIQRKTERRLKRRRKRSERHRKGGFALMEAKEYFAAQFEFKQSLRHDDDCAVTWLALAECLLECHWPREAALAASFSLEVAFSKAAVAFLGKVHLSQGNIDEAIDCFQQALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XKN7</accession>
    <name>A0A6G0XKN7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Crinkler effector protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_003838</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Host cell</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000043">
        <property type="protein sequence ID" value="KAF0740797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XKN7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013479"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043657">
        <property type="term" value="C:host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045379">
        <property type="entry name" value="Crinkler_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20147">
        <property type="entry name" value="Crinkler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Crinkler effector protein N-terminal" evidence="4">
        <location>
            <begin position="4"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0740797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="378" mass="42341" checksum="72B916D97F3BC6BF" modified="2020-08-12" version="1">MVLLCCTTVGAVECVVVEIGLEEFVFTLKTKIQELLGYPRLAKDLELYLALANGQWLGAEAVEKGELTETINELVQRDKRLMSGVSVGKYFVGQTKPAITVGQVHILAVAPKHDAAGSMQVVKRDLVQLKDTIARVVEGVLKTDRTSWSCSKVSTDRIKQIGYEPQYVPWPTMDDVLLERDYPEFKSTDGKSKNHRTQMELYKEYFGAVLEVTKHLWIKTDLELDVPVGKDQHLQKGRAVLYLVPNESFTCNEIAMVIEVRPGSREETLSEAQHAQTMGYCLAANAHFSRGDDRPSPVGLLTNLNDALCFFWVNPKGKICYASTKKNGQPLDRKTALYYMRKHCDHVNSCIEDLSSSNDISQDRHVVFGTIPSGLLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XKZ6</accession>
    <name>A0A6G0XKZ6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_003809</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000042">
        <property type="protein sequence ID" value="KAF0740922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XKZ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011558"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="315"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0740922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="391" mass="43965" checksum="2EE08F7DBA54316C" modified="2020-08-12" version="1">MAKGASRGGGGANNAKEMKMFLKNRMWKEHWQVLVGSVVVIIALFAWIFLQAANSKQVLHHIQLTNSNDVDRVFRSGEPWLVLCSNADAVLPEVFDKASKRVVGKINVGVLDCHDKLPSGKSVYNKFLLREDISPTVFTIANGEKPKQLFLNYLQKPKILATQALEQVKKTLHEVQNTKQLDDKCLGKKSSCVLVYRTGKKFNDYEKQWLQSIMENHRQTAFVWMDASILSLSVESLFKKAATQGQNRLVLFKKVKGNGNAAPSTVAKAYTSYFEQLPVESFIDEFGGVSTDESAFRPLTKSVTITRRPKPTPKPTAKPAQTKPSPANAQPTETRTPQEIAEIERQRRERMEEESKSHYPEYVDEDEIDTTTATEAGEDEDDSEVLDLDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XMJ9</accession>
    <name>A0A6G0XMJ9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">T-complex protein 1 subunit eta</fullName>
            <shortName evidence="10">TCP-1-eta</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">CCT-eta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_003358</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 10">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterooligomeric complex that forms two stacked rings.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000036">
        <property type="protein sequence ID" value="KAF0741689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XMJ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001393"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03340">
        <property type="entry name" value="TCP1_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000022">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000006">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012720">
        <property type="entry name" value="Chap_CCT_eta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02345">
        <property type="entry name" value="chap_CCT_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="526"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="549"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0741689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="578" mass="62347" checksum="2BA3B84B0CB2455E" modified="2020-08-12" version="1">MMMQPQIILLKEGTDTSQGKSQLISNINACQAIMESVRTTLGPRGMDKLIHKGTKTTISNDGATIMGLLDIVHPAAKTLVDISLSQDAEVGDGTTSVVLLGGELLKQAKPFVEENMHPQTIIKSYRKACQLAVQKIKEIQVRVSEADSIAYRQMLERVAGTALNSKLISSHKKFFSPMVVDAILSLDTDMDISMVGVKKVPGGSVTDSFLVKGVAFKKTFSYAGFEQMPKYFTNPKILLLNVELELKSEKENAEVRLDDPTQYQSIVDAEWNIIYDKLDKCVKSGAQIVLSKLPIGDLATQYFADRGLFCAGRVAQDDMERTMRATGGAIQTSVQDITPNVLGTCGKFEEQQCGNERYNLFTDCPKSKSATIVLRGGAEQFIEEAHRSVHDALMVVKRTVATSTVVAGGGAIEMEISRHLREYSRTVEGKAQLLINAYAKAFEIIPRQLSDNAGHDSTDILNRLRQKHFKDPEAGKWFGVDINTGGICDTFESHVWEPAANKINSVAAATEAACLILSVDETVRNPKSEQPQAGVGGGPGGAPLSAAMGGQGMKGMAMGGRGGGLGKGVRAFRGRGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XNN6</accession>
    <name>A0A6G0XNN6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Magnesium transporter protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_003060</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the OST3/OST6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000034">
        <property type="protein sequence ID" value="KAF0741869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XNN6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000960"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021149">
        <property type="entry name" value="OligosaccharylTrfase_OST3/OST6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12692">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12692:SF0">
        <property type="entry name" value="GH11935P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04756">
        <property type="entry name" value="OST3_OST6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026191560" description="Magnesium transporter protein 1" evidence="11">
        <location>
            <begin position="25"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="332"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="301"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0741869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="396" mass="44783" checksum="3E043A9347E42366" modified="2020-08-12" version="1">MVKRRATTLLGVVAVVLFLYEVSCMGKTTQVDLNQDVTVTLDEMSDHSAKLLYWNLRQYNSFIVNSTRQFGVAVLITAASPSYRCEVCGQLEADFKVVAQHYSRYRFNRSNPLPLYFAVLDADRIREFFLKHKISHVPLLGYFHPKSDDHTDNNFHLSAGDSLLGTTSILDYCNQMHKTDIPRMVSIRRTFTISSFIALIFAAMAHYAHTNFDLLLDLFRNRWFWFCVSLAIYAFSISGALLCIFQPATETSPVGSNKASISSWLVHPNPTEQYVLEGLLATTLSCLFGWTLVYASRRSHPPSGASGPPGRSNSTQGGQGPLRHLHVTVQNCMLLAVLVYLVLALATLAELKIAEYSVWATLPPSWRHAWNQLYLSRYTNWIPHVVSLFQRWIAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XPA5</accession>
    <name>A0A6G0XPA5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_002770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000030">
        <property type="protein sequence ID" value="KAF0742096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XPA5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000182"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="143"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0742096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="287" mass="31428" checksum="245C6CCD7548FC5F" modified="2020-08-12" version="1">MLRELGAADFLAFTAAYRQADPIATNQIAGFAMAATDTTESRFWAVLEGDDVTGIAMFKPSRGVMLTTSVSPGDASILALDVVSSVDGIVVFITGSSASVQAFIEAYTRAHPCKIEAHWTQDVVLYAMDDDLNVDSRRFQGRMRLANAATDYELLIKWIHALDESIKALPRGEIFIHEGLKRQSLFIWEVDGVPVAFGGHYPAVNIGNERVVRLGPIFVDVSHRRKGYGSALTVAAIQHLRETSSMPPRFCLSTDASNVASNKAYQNIGFVMHSRSTRFGLRTAEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XQ25</accession>
    <name>A0A6G0XQ25_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_002655</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000028">
        <property type="protein sequence ID" value="KAF0742381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XQ25"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017505"/>
    <dbReference type="OrthoDB" id="301415at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031037">
        <property type="term" value="P:myosin II filament disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903013">
        <property type="term" value="P:response to differentiation-inducing factor 1"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.200.10">
        <property type="entry name" value="MHCK/EF2 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004166">
        <property type="entry name" value="a-kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051852">
        <property type="entry name" value="Alpha-type_PK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45992:SF2">
        <property type="entry name" value="EUKARYOTIC ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45992">
        <property type="entry name" value="EUKARYOTIC ELONGATION FACTOR 2 KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02816">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00811">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51158">
        <property type="entry name" value="ALPHA_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Alpha-type protein kinase" evidence="6">
        <location>
            <begin position="136"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0742381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="435" mass="49075" checksum="C1271F5A7F599D22" modified="2020-08-12" version="1">MIPATGESTNEVKTSNLSMLNSMGPLAVISEARDEDQETIVPNNRHGDEKDKIEKQKQSHFEKLNTLKLLLDTGHLTQEEYIERKNQIINEMTGTSAERVHHRSKPKKLQPIMKTVVPHNPPDFTHVMKERAEKLSFDAETLEWQSSQTIVKLDLVPFATGQLRNAYFLQDLGMHGDSEGKLFVAKIIMNGAEPNAYLCDVEMQAVCAHYAKLYNEHEPPLKVKYASSWLLKLRDRQDLVCCVEEYLPGAYVKYSNNNGFVGKETSTTEERERNTPQAFSHFTFVSSDYRLMVVDIQGVNDSYTDPQIHTVDGRGFGVGNLGTLGMEKFLESHRCNEVCRWLGLRSLNEQFKPGGTAAPLYRMPHEAIKKWITEERNTFSQSVTVSEVLGTTTLVTETTSLLHKPPDVAPSFASKVWSYLRLLCCCGGSGQDRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XSL3</accession>
    <name>A0A6G0XSL3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_001823</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000017">
        <property type="protein sequence ID" value="KAF0743346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XSL3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013633"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF192">
        <property type="entry name" value="DOUBLE HIT, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="292"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0743346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="461" mass="51525" checksum="1EF7B8B8B788CAB6" modified="2020-08-12" version="1">MAGGSQALFAILVFISCACPVVIAIFVSRRKFPSIRYANPSQAAACSSCAALLSLGSSIMLVCQERVACGTFNVFLYVLTTFTLFSIVLTQMTLIITFRLTQELALHHGDNSEAVKSQSLATISKFRRFLQPRVLVAMWIVGSIVWLLPPLAAVDSDSMRQMQALSVADCVNMPLNMPLNVVLLTEVGLFIVAFTALSLLLSKVMDNFGLRHHFQVMSRLLGLLLLINVLALVYHSTPWVITYKIRFVVLPVAGWVVVACQVGWPLARSWTERPVRATNVTGRSFNAASSAALEDFLATEEGYLAFSAFARLEFSLENVVAWKAAYDFKKNGGGDAQKIYTEFMRPGAPMETNIPDALRQHYQKIFEHDRFKSKANVLDAAIAHDPTVFDPFREAMLKLMTLDTLPRFQKHALGQQWTRFLVEQTHEEVHANFMMSLSQREIDPVPMERSQAYLFPAVDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XSM2</accession>
    <name>A0A6G0XSM2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine/threonine-protein phosphatase 4 regulatory subunit 3-like central domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_001790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000015">
        <property type="protein sequence ID" value="KAF0743495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XSM2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019892"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030289">
        <property type="term" value="C:protein phosphatase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072542">
        <property type="term" value="F:protein phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006887">
        <property type="entry name" value="P4R3-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051137">
        <property type="entry name" value="PP4R3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318">
        <property type="entry name" value="ATP SYNTHASE GAMMA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04802">
        <property type="entry name" value="PP4R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine-protein phosphatase 4 regulatory subunit 3-like central" evidence="3">
        <location>
            <begin position="40"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0743495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="617" mass="69619" checksum="881485796590A415" modified="2020-08-12" version="1">MEQETPEKGTTTTDVTSSLALPAMHSLVEIQKALVVPILPPTKRAARVKSIVEHEAQFVKQLIEVADQCRDLDDDESLELIFQITKSLFELCDVSILQVLLADAHFLDVIGLLECNPHTISKMSFREDLASSMKFKEVIPITDPQVIQAIHMNFRIDAIKDNVLSRTLADGCTIWLESLVNENNISILTYISNHEEYMVRLRELVADPETESTGLLLLQNIMRLIQITQPPSRGPHPRVPHVLKADYSGMNPVFGSLHHALFPTTLLPSFAAILTRQNEANRLLVVEMLHHLVMFQSGDLLRVYMADERGDLSEPFSLEWQPGQSLLLAILICFYQAESTRSGIIDLLKHLFHVVPGRDDKFLHMIYHGNYMHWWLHLLNLPDQSGHLYELHAAVWEVLTMCISHHGYRIKYLLAKTPIAQHVTDALASGNKMRMIQAAEFVKACVLRNESYYSTLVTTSTIWESLFGIIAKATPKSPSAVVSAILDMIMTAEAHNCRLILEYIQSHAKLSVLETRFPGVVKCIKMKLSNGGETEEPTPHEDEERYWAQEEQSTMVVVVDEVDDDDVSVPPPLIPLEEREETGIVASPSNAVRKPKKVKNIFSAIQWNSPSKKQKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XSY1</accession>
    <name>A0A6G0XSY1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_001392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XSY1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013325"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF440">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="3"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0743737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="343" mass="38169" checksum="A6BA214463E8164E" modified="2020-08-12" version="1">MAIVAIYVDDLVLLAKNDDTMETLKAQVKARFACKDMGPIHFTLGFRIQRDEGTMTMKIDQRLNALNMLRRFGWDKCHPADTPMKAPLSSADCPSDGAPKDDDLHSKYRQGVGCLMYLMIGTRPDIAYAVQALSRHLNNPGVVHYEAMKRTMRYIAGTQNHGLVYTGSSTVLSAFSDADYATDSATRRSVTGHCTFIGANLVSWCSNSQRIVATSTTEAKYIALAQATREVLFQRSLHRQCGNRQNQASVLYGDKQRAIAVATNPVHHARTKDIDVRYHFIRERIQLQDIAWNMLHLKITSPTLLPNLFIAASSNTCAIDLAFKLGKRLGQTPLNASKCKCDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XTD8</accession>
    <name>A0A6G0XTD8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_001365</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XTD8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020897"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000026">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="322"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0743706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="363" mass="40151" checksum="1A58D76CF6C1197A" modified="2020-08-12" version="1">MSGIIKKVTDFYKKDECVKYYKFGKTLGTGSFATVKSAVCKVDNSKWAVKCIEKASLAPDDEEALRVEVEVLQMVDHPNIVKLKEVFDCPKTFYMVMEEMSGGELFDRIVEKEKYSEREARAVVYKLAAALAYCHTLGIVHRDLKPENLLYASTEDNAEIKIADFGLAKLIQGNSMMQTACGTPGYVAPEILEGKPYGGEVDMWSLGVITYILLCGFPPFYDENNAALFATIKAGAYDYPSPYWDHVSDSAKDLINHMLVVDAKKRFTAEDVLNHPWVKDPDGASDKPMPSFTAEMRRYNARRRFRAGIMAAKAIRGMKLLQKKGDGDESDGEEASPAASPTGRAARGGAVGENVQVSHSRHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XU13</accession>
    <name>A0A6G0XU13_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">heme oxygenase (biliverdin-producing)</fullName>
            <ecNumber evidence="2">1.14.14.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_001535</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>heme b + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = biliverdin IXalpha + CO + Fe(2+) + 3 oxidized [NADPH--hemoprotein reductase] + 3 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21764"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17245"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:57991"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.14.14.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the heme oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.18" evidence="2"/>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XU13"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008457"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004392">
        <property type="term" value="F:heme oxygenase (decyclizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042167">
        <property type="term" value="P:heme catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006788">
        <property type="term" value="P:heme oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19165">
        <property type="entry name" value="HemeO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002051">
        <property type="entry name" value="Haem_Oase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016053">
        <property type="entry name" value="Haem_Oase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018207">
        <property type="entry name" value="Haem_oxygenase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10720">
        <property type="entry name" value="HEME OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10720:SF0">
        <property type="entry name" value="HEME OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01126">
        <property type="entry name" value="Heme_oxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00088">
        <property type="entry name" value="HAEMOXYGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00593">
        <property type="entry name" value="HEME_OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="297"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0743893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="320" mass="36569" checksum="1F80FA16C378061E" modified="2020-08-12" version="1">MPYVANGLARDLKEGTQEVHQEAENVHFIREFIQGRITRDVYRVLVAMLYYVYDELEQQMRDAGDASEPTVSLLHFPDELERVPSLAQDLVYFYGSNWREEMPQPSAATKAYVARLRFIGTTQPALLVAHAYTRYLGDLSGGQILKRTAIRAMHLLNGLGTAFYDFKRIKSHKEFKEMYRQKLDELPVTPELSNQLVQEANVAFLLNMAVFEELDVLSGFSTPEAQREGATMRRQLRRKESPSRVSSACPFANLFGQPGVKEMATKYHDLTPEELNQLEIELKAEQEESRRQTHQRLTMSLTALGIAIGFCFALRRLCLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XUV7</accession>
    <name>A0A6G0XUV7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transmembrane protein 184C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_000919</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XUV7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021059"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0744440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="41092" checksum="013BC82F536BE65C" modified="2020-08-12" version="1">MVSGVFVLVALYVSVKLIRNHLKYFTKPGVQRKIIGILWMVPIYATTSWLSLRFKSWSLLFDMMRDCYEAYVIYLFLALMVAYLGDGSDERVVRILMTLPDLPHPFPFNYWNKPIKMDSSFLRDCKMAAMQFVVLKPLTGFLAILLEHFDLYAQGEFVLNRGYLYISIILNASVTYAFYYLVLFYLALGTHLKPYKPVPKFLCVKAVLFLSYWQSVVLAFLSKFEIIHQVGSWTTNDVTMGIQNVLICFEMMVIAFVHTHAFPYDEYKDYAESLETSSLRDSILSENFAFDDAVRDFNEVMPIVLPSGFKPSSNTRRSEKVIAPGVKLPPKQVTPVAYKNTKKTPLEPVDADRGWKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XVA1</accession>
    <name>A0A6G0XVA1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_000944</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XVA1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001493"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01262">
        <property type="entry name" value="PH_PDK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05581">
        <property type="entry name" value="STKc_PDK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000191">
        <property type="entry name" value="3-phosphoinositide-dependent protein kinase 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000833">
        <property type="entry name" value="AGC family protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033931">
        <property type="entry name" value="PDK1-typ_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039046">
        <property type="entry name" value="PDPK1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF163">
        <property type="entry name" value="3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14593">
        <property type="entry name" value="PH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="13"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0744466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="479" mass="54112" checksum="3694E4651A91792D" modified="2020-08-12" version="1">MAERLKTQSPADFWFGTTLGEGAYARVVHARLKATSEEFAVKIMEKRFISKEKKVKFVMMERKVFSKVSHERIVKLSFSFQDRNYLYMVMELCRGGELLDVITKAQKEQAALGVKNKACSFDVTQFFIAEVIEALEYLHEMGIIHRDIKPENILLNEAGHLKITDFGTAKDETEDGARQNTFCGTAEYVSPEVLRDLEASRGCDLWAVGCMIYQMLVGRPMFRAENEYLTFQQILNHPAEDFAYPEGFPEVAADLCNRLLLQDPAQRLGAGSDADGNGYEALKNHPFFTGINWANLGRTKSPYIPQISPLPPTDSDGATEDWLFAGVATELNISSGLTAEPVIPTESEAVAVEHHHPNPVEIARVRASVPPPSRMNSLWNRFLLDDEVIKMSGLISKRKGLFSKKRQLILTSKPRLIYIDPIRMRQKGEIPWSDNVYITVKNSQQFDVVTPNRVYHLHDQVNGSKKWSDAINAALVQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XWB9</accession>
    <name>A0A6G0XWB9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_001142</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XWB9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018524"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0744685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="453" mass="51575" checksum="0662B8AE59B2CA59" modified="2020-08-12" version="1">MNDVNAAIQALVCRGDDDTWKKLLQEEQRDPQEIKNALLKFIPFAPSLDPLTYPVCAFVQLNPECAVDLWTKLLVFQHDLCNVSELRNWVVHAINLTQTSSTSLDDDVILAIVEACSLAIKTERRRHIAKRIHTFRATLAARVHGALPDREQSSILAHLDELAMHRGSYTTKSLVWAVDFARRYPQDRSPWSDPVVVERIKLLVCLYPELFKTMLHHWVGLKYISLSQSDNLLRHRPLLEDIMISAAHHPMLRRLESSKKHWQSQSLSVRYIDVEEPCSFSTWSSETLLSTATMDILMADMKAAAANCPPYGFDSVALALWALILHMRDHVETHRPQLSQALRLLFSSVLPADLNLEPSKLLAVLVLVAESRMGSWSLWSACPDLLTSVLVFMSKVYGDIDDEQMQWVVGMIVNCFIVQVPDIPQVLAKRAHLLPPNALQLYKQRLQLWRRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XWL0</accession>
    <name>A0A6G0XWL0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_000680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000003">
        <property type="protein sequence ID" value="KAF0745109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XWL0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008841"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0745109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="550" mass="60708" checksum="6B454A6DD0FF625D" modified="2020-08-12" version="1">MKRGSSDKPKGSNPKRSIDLSKAAATTAPAVPDSTADETPTSIPRDVFVIDASEAIAVDTVAWIFEETFLYYTQCERAMRKVFFASRRSVSMIFATIHMGCYINYDPTLPPTRPEVEPLADAVDRHASQAVPKKEASRHPQRLYEGGKAPGSSARSTSERSLRTRQNAVAASRKVSKDRVEPKPAAFQILVHGAGEDGDDDAMDAETKAWRMNCLAELTTTKPSKTKWGKVSVLRHAIGHHEYVGMDSAVIEPLPSIIDTNECEAQQDVLPLDTVRTVPADETLDDASLLLLQPPSFPEQEAEQPVVEDKTRGGHNRRGGREAKTTRKHVKPSWFYETISVKEELKQERDAAYKPHAMALQKDAFARTIELTEGVSLVQGGTKYVGPHRHHSHVAMSRQGFQSHLGTQEHSSNKLKLRTLTAESSRNHSTTDLRALGHADSRHLHRSSASDLSKLTRHKAPSPSIRVRVSPLKADTANARPQARMQYVTHGDSVGVLDIPSHKRRPATAIGALATSPKPLTSKLKYMREFPPPKPEVVTVLKDQKLAWLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XX16</accession>
    <name>A0A6G0XX16_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_000557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000003">
        <property type="protein sequence ID" value="KAF0744973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XX16"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008198"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0744973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="151" mass="16724" checksum="B287F524A21F193F" modified="2020-08-12" version="1">MMPKPPMRPATIKRTASPSLKASRDLASSAEQKNVTLPRISASSPRASSETEGDDETQRVQGAELQHCESILSTIQKETTQNGNRCITMLEFKETTNPVLDNMKDFVKSIQKELGDLEQLCAQGWDTDDIDDMLASIPAKDVSAFKHLWSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XXT9</accession>
    <name>A0A6G0XXT9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_000016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000001">
        <property type="protein sequence ID" value="KAF0745561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XXT9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012436"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="482"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0745561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="637" mass="71532" checksum="0044144686477818" modified="2020-08-12" version="1">MVVLSSYEQTREANIARNKAMLEFLGIEKLKTKSPPKRPRKKPVGPARRSSRVEQVNEVRVKIQQVLDAEDEIYRKQHEQRLRAIRGELKREREELAAMRREEVERRRVEKQLLKIQKQAAKKRRHDEALRLKREHEQERRSKKLEEERRRNVVVFKLPQSFRGLVQPEMGETLFKDSLSSKGRSSDIIEITESSDEDEDPSESSSEESSDDEVSSEEVSSDDELSSDEKLMHSIENAFKRKKPAQQIRYLYKRKVQAEVKEEHAIKLKLPKSAIPTDTSEQHVVKLKIPTEAQAQPQDRPHVIKLKLPTGQSQLEHNIAVKAEDPDEGTLGRRGSSSDSSDSGDGDVDMENNTNDTTFSASPATVQPQERPHVIKLRLPCAPNFTHTNDISNDQFPDEMASLTRPKSNPSSDDLSTEDVDKKKENIANSTALPPIVLPQTLSQERPHVIKLKLPLAHSHDGVNNAVQAEDSDVATSDRLQSALSQSQVSHNSSASSSSEDSDEDAESDTEGSPQSTMKSDVETRNSSSIVRLKLGKRSLADMLHGKAKAHEFQVYLSKGIHGLCMDFDVDATRIKVAGFRRPRPGILGPAEASGMIEVGDELVAVEGDRVLNGEDFKRFVPILKSGLSVTLSFRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W4G6</accession>
    <name>A0A6G0W4G6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein kinase RIO1</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Serine/threonine-protein kinase rio1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">Ae201684_018821</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 26">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 21">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="VJMJ01000358">
        <property type="protein sequence ID" value="KAF0721918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W4G6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016397"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05147">
        <property type="entry name" value="RIO1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000148">
        <property type="entry name" value="Serine/threonine-protein kinase RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051272">
        <property type="entry name" value="RIO-type_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017407">
        <property type="entry name" value="Ser/Thr_kinase_Rio1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45723">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038147">
        <property type="entry name" value="Ser/Thr_PK_RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="23">
        <location>
            <begin position="31"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="363"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="22">
        <location>
            <begin position="363"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="407"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="22">
        <location>
            <begin position="448"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="19">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="19">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00068838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR038147-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR038147-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR038147-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAF0721918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="470" mass="54396" checksum="7C828E75A8FA943F" modified="2020-08-12" version="1">MDYEGALSKAASNQLAQSIRESEIGRTKHTGRDDRATTEQVLDPRTRMMLYRMLNQGIVTEINGCLSTGKEANVYHARLGSGEEGAIKVYKTSILVFKDRDKYVSGEFRFRHGYSKSNPRKMVKLWAEKEMRNLKRLRDAGIMCPEPIMLRSHVLLMTFIGHDGYAAPRLKDARLSESQLRAVYVSCVKTIRVMYQVCKLVHGDLSEYNLLYYKSNLYFIDVSQSVEHEHPCAMEFLRKDCKNVTDFFIKNGLTPMSTIELFEFVTDPRVLSEDEVDAILDSIQSKIQVRPDTRTNEELVDEAVFMQTFIPSSLGQVLHTERDQLAYTEGRMEKSLSSAISRLEVGQQPRLMDMLNVEELDFEGLEDDDDDDDDDEDEDDDDDEEDDDDDDDDDDSEDEDNSEDDEEVRKQKTLFRAERRAEREQQKAAEKLDKKSNKKAVKEEKREKRATKIPKHVKKRHKKLAKQKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W4P0</accession>
    <name>A0A6G0W4P0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_018972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000370">
        <property type="protein sequence ID" value="KAF0721692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W4P0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016704"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0721692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="324" mass="37344" checksum="011EA439C63AA09C" modified="2020-08-12" version="1">MEFTPQYNDKRREAARKGMSKLRAARKREVEALMAQIENLEGVLGHLKAHPEERHRGINQFVVTRRILDQRNSALKAQVLACNRLIQLLRSWTISRQLYNGYVETHVPHDAGSRRSGFDWLTKKAYNMSLKANEYIPKRKDVADDTKVKLHLGVDENGAQSVLAFECQIQFTIFANYENVAKTWWFDLLESAPLLQSTVVEKVGDHIVYVKQEHVDLNYRRLCLAAVFLDHEKDRITITQTGIAMDDRFPFQGGESRSNGFQWIVFQHVTDNVTIVRWSILSFCPVNAKGPLSLRDMAARCGCTYDITTRIFPIERIIVIQTLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W504</accession>
    <name>A0A6G0W504_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_018578</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000341">
        <property type="protein sequence ID" value="KAF0722245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W504"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001592"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF214">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026209836" description="Protein kinase domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="118"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0722245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="386" mass="42180" checksum="7107934BF6D86C47" modified="2020-08-12" version="1">MATQAVGIACFFALTCVHAALSAPFLNDTLPGLEGNTSAQSELMVLAQIATSSPTSSSHSTHTTAIVITCAVGLSVVSAIIFFITQRKEKNPAVYSDDSYGELDWRDLPQMRLPVEKVRVSTRLASGSMGEVYLGVYEGHKVAVKKLLKTKRSASHVQRLIDEMSLLAMVRCPFVVQVVGVAWTEPQLLLGVVEYMDLGDLHAFLHATRPSTFPFMNKVHSALNVAYALAHIHSLDVIHRDLKASNVLLDSTYGTKLGDFGLGKDAHLEIVLSPGRGTYRWMAPEMLVSHAYDASVDVFSFGVILAELETHREPYSNVKNASKSKPVDDTAILGLVLHGHTHPKCSRHCPSWFSTLVNQCTVFQPSERPTAQAIVTLLKQRIQEGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W5W6</accession>
    <name>A0A6G0W5W6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_019151</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000423">
        <property type="protein sequence ID" value="KAF0721398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W5W6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015083"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0721398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="184" mass="19960" checksum="B9CB521B9510AABE" modified="2020-08-12" version="1">MLQNYSDELCQAPLLLISFSNCPSCGPAKMRRSSLLCLLLALTSFVCVESRAMFHDAILSKLYDKVLVKDREGKCKKEEMKHNVNQIATNCAGLSAAVGIALACSSVSQGAVVVGGVTTSIMTLKSQLDSYMEARCARLVHAASGVAKLKKAMPKMNAVNAFKKAKKSRPAVDVRIPISRRWTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W6G3</accession>
    <name>A0A6G0W6G3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_018207</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000326">
        <property type="protein sequence ID" value="KAF0722728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W6G3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000637"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0722728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="267" mass="29621" checksum="8D66B2088107F547" modified="2020-08-12" version="1">MLNNADAAELLLSLLFGLICVTYGYHTIQFVMVVFSILAILSIAKDYGVQKMASFYIALVYFIAFFVLLPYVPVRHHAIIFLCAKVLFYLGSLAWTAVQIYHAIPMFYISSMVISFTISTWIWVCMKSTERQCLIFTTALMGSYVIAGAIDGWTPDDSFSSNGWFKLAVIIFSTCVGIFFQLRATKEPGQGNARAPTYAFAPRPSLAPTDLSDCDLPRTPHSPSYDFVTVPYVEVVVQPVIHDSPLPDSIPEEVELPPQSKANTASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W7N6</accession>
    <name>A0A6G0W7N6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_017942</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="VJMJ01000317">
        <property type="protein sequence ID" value="KAF0723071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011077"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016503"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019209"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054465">
        <property type="entry name" value="Integrase_p58-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13975">
        <property type="entry name" value="gag-asp_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22938">
        <property type="entry name" value="Integrase_p58_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="9">
        <location>
            <begin position="531"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="52"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="958"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="958"/>
            <end position="970"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0723071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1341" mass="151599" checksum="4FCA9DABA0EFFD24" modified="2020-08-12" version="1">MAPATIEDEDLWLKWFSDTLSKCEEARKANRDCSTNRPIARIGWADVNPYSVLDDEDDYPSDPPGPDLLDESDDESDDTPTYHVAPVQTSIAHIPSSASRIITHPPVAWDDLPIAYPEDELSPIQATKQKVRTLRNYHRRCAKRDPHYNDDLFTDCPGSRRFIARIQPLCHTRPLNGPDPFVKAYVNGAKATTLIDTGATSSFISATFWHHLGRPTLTRPKSNFVSADSSNLEMLGRATFKVCIAGRTVDFPFWVMSTAMTDCIVGIDLLRYLGAVINLRDNTLTLEDGDHLLSLDPLPESHTTQHPMGYALVATTTTVPPRSVSWVPCQAGTDLPRSTTTLLEPSKKTLLHVAAALYTTQPTIYVEVINPSESPIVLDTAAPIGTWTALPQEFDERSPMGPTVSDADVPVATSLSSVPCSIASKDEQPKGVLTALGALGVVCPVQTTNQPTKELPIDWADSSLSVEQRELLRKTLLDFADIFVDTSKAPGRTHLVEFSIDTGDSAPIRSAPYRTSKAEDDIMEAEINQYQDLGLIRPSKSPWASPVLMIRKPDGSIRFCIDYRRLNKVTVKDSYPMPRIDDLIDVLGRAKVFSTMDIASGYWNVPMAKESIEKTAFTCKYGLYEWLVMPFGLCNAIPCFERLMEQILMDYKWRTCLVYLDDCIVFSEDFGTHLVRLRQVLSKFREAGFKLKMSKCKWGRSSVPFLGHIVTPAGLLPNPEKIKSVLRIKPLKDVAEVRAFLGLAGYFRRFVKDFAEIAAPLTALLSADTFAWTPECDHALDTLKRRLVLPPVLAHPDFDLPFSIWVDASHIAVGAVLMQKQQGKNRVIAYASQSLSKAQAKWINKDSGISEIECYGVVWATRKFRPYIDRRHFAIYTDHEALTWLFNTGTRSGNHKLARWAMELQGLDYTVVHKPGELNGAADGLSRQACPILTRSRARHAQTSLDNDGTIEDAVLARRQHHHTSSRARSARFNTPDPPTRDPGPTSKGTSTNSTIELFNARGRPTARLYNEQGSDPEISAIRAYLEEGAVPIDPRLHKRVTRNGQGLVERFNHTIIQMLKIFVNDHHTDWDVYLPRLLFAYRTSYQETLGDSPYFCLFGRDPTLPLDLAFLNSGPSWKSDDLPQYKRRLASSWRLTRTDRKPIEFEEQSSVWLYKYFSKSNDPSDPRARKLATHWHGPYRVHRRLDPNTYQIEVPTHPDKLVTVNVDRLKPFRGYYSRPYNDDVPQSDDEQDDLTLDCLPNSSFVDLVSFPDDDVAYTNSGFPIYRIVDKKREPGTRETDYLVEHVDGSKYWTPLSKLSEYRSYVDDYERQLRMDRGLPPLRRTPRFRDLDIEPKNYTQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W8T5</accession>
    <name>A0A6G0W8T5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_017851</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000313">
        <property type="protein sequence ID" value="KAF0723234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W8T5"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0723234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="234" mass="26283" checksum="13A2CF21DD79543C" modified="2020-08-12" version="1">MVLESISKRNPSNVMSPRHILKTTFGMLESLSWGRLVHDERCITPSCDSINNDPVISILLGEYRPHRVSTLSYVNNNDPVISIFLGDYRHFVSWPSSPSVDRALASHSPSYLRLSMFRLCSTPIHLIVRPTALNDERLLAVVLLLFLTCLTSSVNYPYDGHHGIKPTLRGVSFAHLRLPFYSVIMVCYAGCVGDSCSYCPLGHRCIIQIFLACRHPRTSDFLSHPSFIDNPAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W9F4</accession>
    <name>A0A6G0W9F4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_017333</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000294">
        <property type="protein sequence ID" value="KAF0723838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W9F4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006630"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0723838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="161" mass="18540" checksum="88773479BA5C7EAC" modified="2020-08-12" version="1">MPLEYDTISKLYIESNRDVIVWRTVHKDEMTPDMIKGAVEDQWGWIELTPLENSKHCRLILLMQVMADTNESAPPQLKIDTTVDSIMTTVEQVSCSSIPHLELPTSEPLEEIDRLEVKDGLPPSLLAWLERGRRKEILIRRAVNRAILDFNDTSQREITDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W9K5</accession>
    <name>A0A6G0W9K5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar protein sorting-associated protein 26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_017830</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000313">
        <property type="protein sequence ID" value="KAF0723213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W9K5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009494"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000015">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028934">
        <property type="entry name" value="Vps26-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12233">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 26 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03643">
        <property type="entry name" value="Vps26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0723213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="32688" checksum="0AAEE407AC272516" modified="2020-08-12" version="1">MKSLFGFGTPVELEVVLNGQEDRRKEGDLLVFTPTDDISGTLQTTAKKFDHGGIKVELIGVIETIHDKSMQFEFTSSVRVLSQAGTVDGVQTFPFAFVSVDKPHESYYGKSIQLRYFVRATITRSYATNLTKEQDFLVHVLDTAPELNSTIKMEVGIEDCLHIEFEYNKSKYHLKDVVVGKVFFLLVRIKIKHMELAIVRREISGMGGSDKHTESETMTKFEIMDGAPVKGESIPVRLYLGSVGTLTPTFKNVNNRFSVKYLLNLVLVDEEDRRYFKQQEITLWRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W9R8</accession>
    <name>A0A6G0W9R8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein disulfide-isomerase</fullName>
            <ecNumber evidence="3">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_017264</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000291">
        <property type="protein sequence ID" value="KAF0723955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W9R8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013088"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00238">
        <property type="entry name" value="ERp29c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02998">
        <property type="entry name" value="PDI_a_ERp38"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000032">
        <property type="entry name" value="Protein disulfide-isomerase A6 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1150.12">
        <property type="entry name" value="Endoplasmic reticulum resident protein 29, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011679">
        <property type="entry name" value="ERp29_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036356">
        <property type="entry name" value="ERp29_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051063">
        <property type="entry name" value="PDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672:SF11">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07749">
        <property type="entry name" value="ERp29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47933">
        <property type="entry name" value="ERP29 C domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026294950" description="protein disulfide-isomerase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="8"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="139"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0723955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="358" mass="39128" checksum="13869DF4DF67276D" modified="2020-08-12" version="1">MQSFFALLVAAVSAVVVSASDVVTLTPDNFDSVVDGSKNVFVEFYAPWCGHCKNLAPTWETLATSFKNVDDVVIAKVDADAHRELGQKWEVNGFPTLKFWNKGAKYPDPYNGGRSPDELIAFVNEAAGTNVRIARPFSHVVDLTEADFASIAQDPTKHALVEFYAPWCGHCKNLAPTWDKLGNVFAGDENVVIAKVDATATGELASKFGVSGYPTIKYFGVGAKATEAEDYGFGRDLKDFVDFINENAGTHRTVDGGLLPTAGRVESLDVVLNSAGEFTKDTLSSVEKIVDGLEGDALKHGNLYVKALKKVLEKGYDYVKNEINRLDHLSKDANVSPQKKTLFQLRKNILEVLKKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W9W2</accession>
    <name>A0A6G0W9W2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_017225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000289">
        <property type="protein sequence ID" value="KAF0723987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W9W2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008587"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0723987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="475" mass="55218" checksum="4E9B60A627499FE7" modified="2020-08-12" version="1">MSFVTRQGDGDWSFRLLGHSPSRDDTVTMKKARSSTLSPLSKLPLDIIVKITFYITVGENVLAFLKALSPSIELGPLDELLNSKEEISQLWPRLNLWTDISSYEAIAKYYSNVVIYRTEDADWFEKYLNPMASIEWFVEEFPKASQVYYQFWKLRITRVNICLRWQDERRFSCKNSLRRLAHVISSLCIGDDEYCDDNEDDYHRIWHDLFEFAAKSDQLAELQLFPENHSLTANDAANLIKWFQRGIAQVFEFKVGEFTNVLDEVGPDVEQFFYQAMFTSPLKRLKLSNWDFQHVDLTGISFAMEALQLYNVDFASMEKVIRQLEGSKVKELEIQEYADARMCLERLLRLLPRTLITRLKLTEIDCSNIEWSALAPLFAECHLEFLSVDFAKSIPPWVDTLIAAIQSNQTLCTLEFVWANWTILGVEHLIRRIAYPRRPAKFKRLQLKAWNIKGAESLKALAFDSGFDFVIVSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WA32</accession>
    <name>A0A6G0WA32_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_017057</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000277">
        <property type="protein sequence ID" value="KAF0724208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WA32"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004180"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0724208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="129" mass="14282" checksum="2EF2352AB9EFB6EC" modified="2020-08-12" version="1">MKRTCAASMKRSYSCMDLAALEADASSIMSSCSKKRLTTPPRYRSLSSGPASRQKNINEWLHTYDSLAATFPAILESPSIEDVLSASSIASILPPPTGKEDTMQLELIDMWQQPWIVDKDCSDHSTRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WAN7</accession>
    <name>A0A6G0WAN7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_016957</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000273">
        <property type="protein sequence ID" value="KAF0724292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WAN7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021507"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd15841">
        <property type="entry name" value="SNARE_Qc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="7">
        <location>
            <begin position="119"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0724292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="211" mass="23324" checksum="FD7B48A61067F960" modified="2020-08-12" version="1">MSGGSASSWSAWLDRFDNARSSEQNLNSKIRSGNVSNLGTSVFALQQSVSRLRREFDSMTSGPTPNSIATPQEIRRRDDNLKSLEHQTKILLATYNNRTQGTKGASTLEAGAQMLRVQNQIMQDQDEQLNIIGQGVSNLKQYSLAVKNETDLHARLLDDINIDVDRATSGLESEGDRAEYVAKKSSNFRLYMAILVLSVILVFELIIGGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WAP4</accession>
    <name>A0A6G0WAP4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_016979</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000273">
        <property type="protein sequence ID" value="KAF0724316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WAP4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021487"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043540">
        <property type="entry name" value="RING1/RING2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46076:SF3">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RING1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46076">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RING1 / RING 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="78"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="152"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="177"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0724316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="192" mass="21957" checksum="21315CA03959200B" modified="2020-08-12" version="1">MTTNVPVTDDDNAHRFTRDAYDRHVSNIVHRRLNPNSLYNEVTLIEELTLYDIFRQPRALVSTTIDVPPTLLQAELQCPVCLGIIRNATVIKACLHRFCEKCLKECMRTGIKECPSCRVQIGPKRSSLGRDETFDRLVATIFPDLERFEADEDERIATANTPRRSKQVRPPDNQDGAAKRSKTESRDPNFTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WAY3</accession>
    <name>A0A6G0WAY3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_017672</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000307">
        <property type="protein sequence ID" value="KAF0723442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WAY3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017381"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0723442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="485" mass="56653" checksum="F9C7FDA8D689CCE4" modified="2020-08-12" version="1">MKNFKKLILHLKTFETFYARDNENCTEKSCQQTRKIKPMWSALPLDICVKIALAIPDFQDLLAFIEALRPYKILGPLGHLYNLHRALKWNPFDPYYRYDEMWPTLRLTQSILYSPARPSYEAIARHYGLVSVKDVWENVEWLKTHLNLANQIEWNLRNIQLPLTMEIADARSDLRITRLVMDIQDERALSWCVHVLSRLPHLVSVKLYFGKLDVADFFTYLATFKKITDVEFASVEGWKPTESQLLVLSEWFCDGHLQKFALEAGSLCCDREMKQLFYEAMFNCPTLDTLVLHNCFLVDFDFTGVIFSMKTLVLDRCRLTSFDMQILATRLEKSDLLHLEVNCMKCENTLGNESLLIVQPHTSIKHLGFSDLPMDRRSWLEWTPLLEKCTLEKLTLHTHEMPSMIVRILARTLQNNRTICELILSDTRIAYADLRTLTQSITHPSRHVRAKRVKWTTRYGLQVPPLPVYELRAIASERGGEFLYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WB92</accession>
    <name>A0A6G0WB92_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_017535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000301">
        <property type="protein sequence ID" value="KAF0723568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WB92"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006148"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052050">
        <property type="entry name" value="SecEffector_AnkRepeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586:SF3">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026015809" evidence="1">
        <location>
            <begin position="22"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0723568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="381" mass="42065" checksum="8B785368E919FAE6" modified="2020-08-12" version="1">MPSSWFLLCQDLLTFIATFQSGPHADIVPFRRLKLPSVTTGDYYERLGEVFAPWYALHGPSRVKVLLAELPNMPNVVFAHALAFGLVDVLRLSCLSQTLSSRELWDIAAFGGQVSSLRFLKEAGIPLKHLSAFTWACRRGHLNCVKFFIALGAPISPDAFDSAAAQGHWNILQELSACPATIHAINEAAKRGHLKVVQYLHENRNEGCTTLAMDYAASEGHIDVVRWLHTHRTEGCTTYAMDAAASNGHLAVVEFLHTNRKEDCTSHAMDWAACNGHLEIVKYLHKHRSEGCSVHALNGAARHGHLDIVVFLNESSSMRKAIAPAMSQAARCGHLEIVKYLFNQQSRSESVTSVMEEAQARGHDAIVDYLNQQTNAAANFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WCA1</accession>
    <name>A0A6G0WCA1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_017263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000291">
        <property type="protein sequence ID" value="KAF0723954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WCA1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013087"/>
    <dbReference type="OrthoDB" id="69809at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097431">
        <property type="term" value="C:mitotic spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051256">
        <property type="term" value="P:mitotic spindle midzone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032467">
        <property type="term" value="P:positive regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039302">
        <property type="entry name" value="MAP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21831">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21831:SF2">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14924">
        <property type="entry name" value="MAP10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0723954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="288" mass="31181" checksum="828EBEB1C6F2B670" modified="2020-08-12" version="1">MAQDEALFVLQIIVDTVILDRECVSVDATSLSWVRLAFQLLSFDVVVLDMEIPISMSEPGQEITCPIRRGKSCVFRMQADSLRDALTLKPLSIMILEPPTQATAHLTRLMAFTCVDMVPHDRCVSSKAMSEWVNIQCSWTLYNHVGAAVGIVQGGVVLSHLGTTLAPHLQNALGSVQLTDIGPTSVVGSPPSPPPQKERDCDLAVQCNIATSPVPTSKPKACKVEVAVQCTESPPSDQIASPKLPLPSVTTNPKIDGEDDSDAFLFEHPSPPPLVFQREPCQHCLLHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WEB5</accession>
    <name>A0A6G0WEB5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_016421</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endomembrane system</location>
            <topology evidence="10">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MNN1/MNT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000253">
        <property type="protein sequence ID" value="KAF0725023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WEB5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000035"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046354">
        <property type="term" value="P:mannan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646:SF1">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0725023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="626" mass="71138" checksum="E794D745F8ED01E7" modified="2020-08-12" version="1">MSSRGQNSLSNRPGATQNAPPSARMNAIKRYSAPWHFISVGLSLFILCAVGLYHQVQYIAITQAPNLRVEQAPAKHIEVFPPGNPFASYQCIKWRQTGGCSPDGQREADNDRACDDPIAGGLSGYCEFYDPVKNETVHFLKMTCGTVRGDIHFSCNMAMDILMFNRHSTVYRHPWNMHGDPQTREYLKHEEFTPTTVKRNTYPPAKRVWYDQGKDDKKPSRGIVMVVYDKALVPLYASVRYLRHDLDSALPIEIWYRSDELNATNPVLQSLLALPDVTLREILDPLATSFYVKPYVIFFSHFQNVLFLDADNLPLRDPDFLFDTTEFQTNGALFWPDFWHPGHTIFNVHSDSLVWPMLNMSFVDMFEQESGQLVIDRARCERALHMLMFYAFHRIRPQEPKRIHIPAGFTVPKNAAKLPDKPNLIAALNLVWGDKDLFRLAWLKTGTPFYMMEHPPGALGFFGKPPAFDIFGNALDHDDESKPDRFCGQSMVQYDKKKRPLFLHRNTIKLGVSPTSRQRQWFEYQEFRDGHEKKDYVIEAWGERSSCFGVKFGSTDSFSMVGTKGTNIEHAETQLLKYANEAAAMLPSETTRGPTTAPPPGSVVPVSAPLGGLPVPARTTFDRGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WF70</accession>
    <name>A0A6G0WF70_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_016467</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000253">
        <property type="protein sequence ID" value="KAF0725070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WF70"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003471"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050776">
        <property type="entry name" value="Ank_Repeat/CDKN_Inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201:SF15">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="83"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="230"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="263"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0725070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="524" mass="58547" checksum="AD77D2456CFB1B64" modified="2020-08-12" version="1">MFKLLLHHYSKMGVLLVIAAVVWEYPRIMLFQYLLGMLNDSIQRNAQPRWLTIFHTTVLVAVVAVVAKDITATDYQVHSKWKYALATPMTLCGGLVRILGVPVYSLVVAVWEAVVVLQGFPLDEAQYNRLHNAYVQELRSRQHVPPHLAANIMFSPKTQGPQVETILSYARFSGKIVLALFFCFVYGLATFCNAPGQDGEHLRDAARNCDVDSARRALSRGTDPNSKGQDKGTALHICGQQALPEMARLLLEAGADPNMRDSLGFSPLHWAVQLRREEPCVDKRLEMIRVLLEYGSNPTLEDYRGNTPLSIASRTENARAGQVIEMFTHYSPHRARMKSRKPGENAAECSRMHEAPCNRERLKLYWTRFDQPTGKHVSYHTRAGQTMEGRGTTRAARLVLVARRLLLFTQFEVLGTLDWQLLLGLAFLAFHTQGNLLGGLSLLVEDGLGLTTETLLLAVVTASTLRVLGGLTSLVLGHLVRGVLAALLTRAKRTAFFRDVHHCLHHTRHELCLFICLSAAFSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WF80</accession>
    <name>A0A6G0WF80_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Endo-1,3-beta-glucanase btgC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Laminarinase btgC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Ae201684_016477</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation. Active on laminarin and lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000253">
        <property type="protein sequence ID" value="KAF0725080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WF80"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011736"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF17">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE BTGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="15">
        <location>
            <begin position="338"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF0725080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="475" mass="52258" checksum="7C54B0E0F454E351" modified="2020-08-12" version="1">MDLQTPPQVAVPTPAVEYAQAAEEAIAPVVQSTNSKKKRALLALAAALVVVGAVVGVLVATAKPSMPSSATKTSAATGIDISVCYDSYSDSLIAQHFQTIRQRFTGVRTYQTRGYMNAIDAAAQAGLKIYAGVWLRTDEASISADMQAVVDGVKRNAWAVKGVLVGNEDLINGLDQWTVLWRVNQMKQLLSAAGYGWIPVGSVQTDGSWLSATGLAAGCDIIGANIHPFFSSWPDSTWNPVGDLDNRWKALFGKYGSKCVLTETGWPTSGSQNYGHWPSMDTAKSLFSQFQTWARNNGGDMPSFFMFHDNTKKSIDYEVSFGLAWANGYWKFDTSNDIGGIAFVNPANDKVLAMTDNRQVEFHSRWGNDWVYDYNSLWTLRGPLVVMWEASTKTDVCLDAYEPWNGGTVHVYPCDANNANQQWVYDSVNKQLRHIKHAGFCLDMSSASGGTPHLWECHATNDPWYSLQQLNLWSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WGE2</accession>
    <name>A0A6G0WGE2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="11">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ae201684_015567</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NAD(+) = N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="9 11">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="11">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="11"/>
    <dbReference type="EMBL" id="VJMJ01000225">
        <property type="protein sequence ID" value="KAF0726108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WGE2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020169"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000001">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000001">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050151">
        <property type="entry name" value="Class-I_Pyr_Nuc-Dis_Oxidored"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912:SF223">
        <property type="entry name" value="DIHYDROLIPOYL DEHYDROGENASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912">
        <property type="entry name" value="DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 9 11" id="KW-0274">FAD</keyword>
    <keyword evidence="2 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9 11" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 11" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="13">
        <location>
            <begin position="27"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="12">
        <location>
            <begin position="374"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="472"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="167"/>
            <end position="169"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="206"/>
            <end position="213"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="346"/>
            <end position="349"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="10">
        <location>
            <begin position="65"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF0726108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="493" mass="51784" checksum="3B64B42320382EE8" modified="2020-08-12" version="1">MLALRSLSKNIRLARSSAAAFSTSPDYDLVVIGGGPGGYVAAIKAAQLGLKTACVESRGSLGGTCLNVGCIPSKALLHGTHLYHQAQHDFKHVGIKADNVSIDFGQLMKSKEKSVKILTGGIETLFKKNKVNYIKGFGKIVAKGQVAVTLNEGGNQTVNTKNILIATGSEVTPLPPVPVDNEAGKIVDSTGALSLKRVPKHMVVVGGGVIGLEMGSVYGRLGSKITVVEYADKICPTMDHELTKEFQKLLTKQGMTFKLGQKVTASKVEGDVVTLTVEPAAGGEATTIEADCVLVATGRRPFTAGLGLEDMGIQTDKHGRVKVNLSNFSTNVDGIYAIGDVIEGAMLAHKAEEEGIAAVETIAGKHGHVNYDAIPGVIYTFPEVASVGKTEEELKAANVAYNVGKFPMLANSRARAVGETDGFVKVLAAKDDDKILGIHIIASNAGEMISEGVLGLEYGASAEDIGRTCHAHPTLSEAFKEACNAAYDKPINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WHV4</accession>
    <name>A0A6G0WHV4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_015031</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000207">
        <property type="protein sequence ID" value="KAF0726775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WHV4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003321"/>
    <dbReference type="OrthoDB" id="67277at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052050">
        <property type="entry name" value="SecEffector_AnkRepeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586:SF3">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0726775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="249" mass="27737" checksum="B1F96192F3C8A922" modified="2020-08-12" version="1">MLSVPRPPAMIPTFDDDEDAEVLRQLPSSIHRYAFEHFSYRDMNVALGSVLDFEDAVSGLYRGHGVIGASALLSWKPSLANIVLAHAAYFGHDDIFRFVHTTFSLSVRRELMELACRNGQLTVVEYLESQRCPVGCLDAAASNGHLDVLEFLKSRRPNEFVVSHAAMANAARNGHADVVAFLYECNVDCQAGAFTDAAANGHIDVVKFIMEHYHDTDLEKEALWQATRHGRLAVVHYLAVQYVRTNGFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WI97</accession>
    <name>A0A6G0WI97_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_014920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000204">
        <property type="protein sequence ID" value="KAF0726929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WI97"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007418"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37471:SF1">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37471">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="302"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0726929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="540" mass="62394" checksum="F1D6267DB7082272" modified="2020-08-12" version="1">MTVIDPQCIWTSDGKAMQTRSKSRVANVPPRSEPSAFDVVKPGADDTKARSSKPVDATTTWDFYLVYGFVILPLRAIVFGAPVVLAFLVANALGWAGEPVQKPWVVYPLMAYCASEVLFTLRYLAQKRRVSPRNPDSPRVEPVYAQRKERFESTLTFANRVIAHTPDMQPFIESVFYDVPFEQLSRKDLRALVAYLFYHKCWTEITTEMKEVDAIVTSIYKAVGMKETNQKQLDHDIKPLIRHTIDDFECLARPWLLYAITKSIYAVGHLWLGFQGFECFHVRRGFTYWRRPAVKQPVSAEPIVFVHGIGSGLTMYLPLLLDLLAENRDRDVYLLDMPVVSMQFCDDALTRTEILDSIDVMMTRHAIPPCFWMGHSLGTLTCSYVCQDRPEWVAHVTFIDPVMFYIWRVGICFNFLYRVPRNGMQAFIWYFASQEVHIAHAMRHHFFWTEMILFPEHLPFCPKTNRFHASIFLSGDDEILDAHATYLHLQHGIQKHFQQHDKDAINITLWEGLHHGQMIIDSTCRRDVLDTLHPRQTKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WIQ0</accession>
    <name>A0A6G0WIQ0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acyl-coenzyme A oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Ae201684_014819</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2,3-saturated acyl-CoA + O2 = a (2E)-enoyl-CoA + H2O2</text>
            <dbReference type="Rhea" id="RHEA:38959"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="ChEBI" id="CHEBI:65111"/>
            <dbReference type="EC" id="1.3.3.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the acyl-CoA oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000202">
        <property type="protein sequence ID" value="KAF0727082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WIQ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013848"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003997">
        <property type="term" value="F:acyl-CoA oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033540">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA oxidase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000006">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000013">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000015">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000003">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055060">
        <property type="entry name" value="ACOX_C_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029320">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002655">
        <property type="entry name" value="Acyl-CoA_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="ELECTRON TRANSPORT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909:SF250">
        <property type="entry name" value="PEROXISOMAL ACYL-COENZYME A OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01756">
        <property type="entry name" value="ACOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22924">
        <property type="entry name" value="ACOX_C_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14749">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000168">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 13" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-coenzyme A oxidase N-terminal" evidence="16">
        <location>
            <begin position="30"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="15">
        <location>
            <begin position="148"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-alpha1" evidence="17">
        <location>
            <begin position="288"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-terminal" evidence="14">
        <location>
            <begin position="511"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="438"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF14749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF0727082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="660" mass="73552" checksum="F2EF117AF6BBE77F" modified="2020-08-12" version="1">MSSVSSDAPRELADLAPLLLKKERSTATFDVQSLIDVAVGPRDVQEHRKRLLELVKNDPVLSDRDMIHRNHKERYENALGKSYAFAKLLEKHNITDWDDTTTVYTFIGEPLPIDVHRSMFIPTLETQMDDEQRAYWVPRAKAFQITGAYAQTELGHGSNVQGIETTAHYDVKTQEFILNSPTLTSRKWWPGGLGKTANHCVLHARLFLNSKDHGIQAFLVPIRDTKTHETLPGITLGDIGPKIGFQSIDNGFCALNNVRIPRRNMLMRFAKVAPDGTFSKPPSDKLVYFTMVKVRVGIVYFCGRALGMVTTIGTRFSAARVQGATGKGKSENQVLDYENQQLTLFPLIGLSYAALFSHRAIDKLYNQVLAQFDGELGVDHLYLLSQLHASASGLKAFLTEETGNGMERVRRACGGHGYSASSNLPYLFQVYIGACTYEGTKDVLVQQHGAFLLKCLRNPVPVSNSSSLDLLGFLQANPNSTCPATRPEQLRDPEILLTAFRVRALKALLRADANKNSLHYLTQASLAHAESIVLSCFYEGVVGVQDTKVRVVLLQLFQLYALWRIQANLGEFRLSNYLSSAQGAWVDEQVLALLKVVRPNAISLVDGFDFSDFELNSTIGRYDGDIYRALIDRATKDPLNKTDVVPGYHQYLKPLLTAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJD5</accession>
    <name>A0A6G0WJD5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_014586</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000198">
        <property type="protein sequence ID" value="KAF0727326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJD5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011072"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0727326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="486" mass="53966" checksum="B61A7F576832C5DC" modified="2020-08-12" version="1">MKLMQEAPDVELLDEIERQWQIWAAPFDESSRFVGNTSDSMFIRNSSLVSPRPFRCLYWERKFRTMLGQPLASRLTMPINLFHGVVFEVKLRGKELSDENVDCIISIPSIHRVEVHHIDATDQTFWPRLGQLIVQAPNLMELCLLHSKLLTLSPLVDALGHRSERPLDMLEFVSIKMRSSVFVELVHLVSSSKLIRSLRMTNSINDLDASLLVPAIASLDTVLLPFNDLEDDVLATISTSMTTQRLCVSNNCFTNVSALARCANLVQLDLSHNELGNAGIATVASVCLPAMSRLTNLYVYNCAFSAVGAAALFAKAVSSSTLLVLNAGRNFLGVEADDVLVPFLNHNASVTHLHLNYIGLGHDISDSLAAAFSQNSHLKQISLGENRLKDTGAAKLFAALPFPLEALDFSGNLISNDGLKSIVAHISELRQQPKRQRSAHIIQELNLRDNVFDVEHLHRHAMALATSVSNIYSNEYRPKTYDDNLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WK46</accession>
    <name>A0A6G0WK46_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SWIRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_014431</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000193">
        <property type="protein sequence ID" value="KAF0727606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WK46"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021628"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000020">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032451">
        <property type="entry name" value="SMARCC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12802:SF41">
        <property type="entry name" value="BRAHMA ASSOCIATED PROTEIN 155 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12802">
        <property type="entry name" value="SWI/SNF COMPLEX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16495">
        <property type="entry name" value="SWIRM-assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SWIRM" evidence="5">
        <location>
            <begin position="262"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="562"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="562"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="575"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0727606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="698" mass="75894" checksum="0CBA3A0C24C9B253" modified="2020-08-12" version="1">MAEAAIKLDRPIPGETRDDDGFRKAALQVVDNLTQETLQKLVALRQSGVLPGLFFRDTTFLTSYVLPLLPLAVDSSKVVDHVKETATKNNDTSVVTLLSRSNVELTTQDVQINHDGYRAVGALGDYTVVHWPGLPDAFDTYVLGVPSPTHPETIDLLIAATAVSSDFNKAMTKYAPMWVNPLDFALNSTQTFHSGSIVPPPPKKRKVDTTILQRLQGDAASAVATLLKESAQPASNPLLYGHLNPSPAPTVKTAFGVDQPSVVVPSCSRWFSLHSVHPLEKRMLPEFFQDNKSKTPQIYMTYRNYMVNASRAAPHVYLTATACRRNLAGDACSILRVHEFLTHWGLINYNVPAHAAPQGVPPTTSFDMPPVVQAPLAIAQEFSCESCGQPRVDYELTADAKRKERIVQHGMPLRKLDAWGVRPGSGICDQCFAKHKFPSHLDPSDFAAVTPFLSVSSWSDDEIDRLLDALNKMDTTTAIDWNEVALVVGKPAKDCVAQFLKLPLESHAQKPQEQPPAHPTSKARVNYPYISAVSDVAEIVASADPSLVQAATAAAIAHLDKLNQPKQDPARETKGTTAATTGGAQALAKSAKDAGMTIKEEASTHEAAAKTQTTAAVAVAVLAARAHGIAKQEEGTVKELMADLLQCQMQHIQLKLKSLEYLESALQAERDQLSKERYELYVDKLNTAQAKLSASIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WKN5</accession>
    <name>A0A6G0WKN5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_014250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000188">
        <property type="protein sequence ID" value="KAF0727815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WKN5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016280"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18316">
        <property type="entry name" value="BTB_POZ_KCTD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045068">
        <property type="entry name" value="BACURD1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11145">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING ADAPTER FOR CUL3-MEDIATED RHOA DEGRADATION PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11145:SF8">
        <property type="entry name" value="RE57120P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="162"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0727815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="278" mass="30408" checksum="6206B059067D4FF6" modified="2020-08-12" version="1">MESASPSPSAKAELSPTSSVGTTQPLSGTPNESAHHFVVKKGRPLHSIWSVFTDKVNAHLLSEGPRAPCKHCNNVVLHHNKTACVERHLKKCVPFLTRMHALPTHERPDWFNNPRSSKKSLDAASLVFSIKKQQQTKSAVYSTTSAASSSFLHVAAAATTSPTVKLNVGGSLFETTKATLLQHEHSFFHDLLVNGHPRADGTYFLDLDPKSFGHVMDFLRFGELSVEGLTGWDRRKLAKTMAFLKLQLPPWDPLTESAALEKTPSSSSIPSPAPVHHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WLM3</accession>
    <name>A0A6G0WLM3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mis18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_014001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000181">
        <property type="protein sequence ID" value="KAF0728175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WLM3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018538"/>
    <dbReference type="OrthoDB" id="74210at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034752">
        <property type="entry name" value="Mis18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004910">
        <property type="entry name" value="Yippee/Mis18/Cereblon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16431">
        <property type="entry name" value="NEUROGENIC PROTEIN MASTERMIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16431:SF1">
        <property type="entry name" value="NEUROGENIC PROTEIN MASTERMIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03226">
        <property type="entry name" value="Yippee-Mis18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51793">
        <property type="entry name" value="MIS18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="10" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Mis18" evidence="11">
        <location>
            <begin position="24"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0728175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="171" mass="19073" checksum="7454553961632C9F" modified="2020-08-12" version="1">MGHWGNLMHASEAGDEEVVEVPFPVVFQCRTCRAIVADSTAFSSSNVSNRTITFSRVAHVEKSEKTASEGGNSYYNLMCTQCDGRIGKMYIGTVRALDPIRDLYTLDADALTNYQIGTQLADDAPSPTTRSLDYDTSTAVIEQLRTDMDQVQNYLLLVDERLCDMEQDLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WM09</accession>
    <name>A0A6G0WM09_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Enkurin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_013722</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000178">
        <property type="protein sequence ID" value="KAF0728357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WM09"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016496"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="135"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="251"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="407"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="307"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0728357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="467" mass="53396" checksum="BF516E8EC5E19176" modified="2020-08-12" version="1">MSEWETWSDGDDLLSWKSLCLSELKPRFHYDDTDSELSVQEVALPTYVYPSVEEREMLSTSQWIYPTEKPKQRLPVSLQTAQFIPAAIPSRPAKPPSPVTTPEPSLHFQSSKENLAVFPLQHIQRQPDPSEKLRLELQTAKCASLEAKVRELESRDSDLQAKVSSLEIKLKAMTDRHHEAIVSHQREIRIAEEARSALESQLQAKEARVVALEAEEDEQKKITALLEAKMDTLQTQLAEKDRSAQIDAQALARKDNEMQSLLAKLDKCTKAEEDLRETLKQKNAELDRLRKEFTKAQFELSRRKTEPPAPAVLPPPPPLRDFMTTKQLPVVSWSMETPRAKSLSELGFTAPVRKLDDVNSSTNVRNLLSYQVQPLEDSPAAIRRVDTELSAPFATEKQTIQTDVLAKRELEAQLLQWHIEKAQLQAEYAKLEQMGFRTIEARRRKSEIETRLDHADKHISHLKLRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WM97</accession>
    <name>A0A6G0WM97_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_013789</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000178">
        <property type="protein sequence ID" value="KAF0728426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WM97"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0728426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="116" mass="13332" checksum="216A94F9E3A92D47" modified="2020-08-12" version="1">MTETVNPVEVVGDREVILRDTAHRADLDRDLMTDETDRVAEMIDVTTGETTDEADALQVVRMIASARPDVVAVMIVDDVRPRRAKKRHQRQHLHQLHQRTLHLVTLDRLLNPQLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WMM9</accession>
    <name>A0A6G0WMM9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_013539</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000175">
        <property type="protein sequence ID" value="KAF0728576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WMM9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010943"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43948">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43948:SF10">
        <property type="entry name" value="MRJ, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="8"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0728576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="335" mass="34865" checksum="CF201FE32D288ECA" modified="2020-08-12" version="1">MANFESDDYYDNLGIERTATEAEIKAAYRRLAIKYHPDKNLTNRQEAEKKFKIVGEAYNVLSNPKNRQTYDQHGKAGLQDIAQPVTVEMALAIFEDFYRFGDAMDPEAPDAGKGFKRAAAGAIYAPVKGVVYGGRAILGGVVAGTAAVAVGLGGMAVSIGMGVKEMGEAGINSITKPARERRASSQSDNQRTSDASSIAADEKSSRDSTTRQKTPPSSDNNSTPVLEGEEHHVPTFMGGLKKATVGAVAIPVAAVVSGGAFILGGGVLAGGYVVGGLAGAVNNVQSGVKEVQAARQKKSDAAESQSIVRVAQAVPVAQAVPAAETAPKSIDQDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WPA5</accession>
    <name>A0A6G0WPA5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_013195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000167">
        <property type="protein sequence ID" value="KAF0729218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WPA5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014553"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF44">
        <property type="entry name" value="PROTEIN AIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="2">
        <location>
            <begin position="46"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0729218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="198" mass="21487" checksum="44987D2254352985" modified="2020-08-12" version="1">MVPTVVAPRTTVSNSASSTKSLCSTSPSTTLTHPSQLAPWIPNKTFESFLPKIDEVVAYFKSEHGVTKFGAMGYCMGAWIVAKYSATRGNVLSAGISFHPSWVFEHLFHGEGSGVKIAEQITVPQLILTAGNDVEWIKPGGDVDKILASRGVPSVLREFPDVLHGWVIRGDLSDPVIAEAYRAAWDDEALPFLKKFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WPN6</accession>
    <name>A0A6G0WPN6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_013059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000166">
        <property type="protein sequence ID" value="KAF0729313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WPN6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018388"/>
    <dbReference type="OrthoDB" id="63973at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0729313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="117" mass="13148" checksum="B796883CA1B82E5D" modified="2020-08-12" version="1">MPGIAALDMDEVERESSTAIPAPLSASPNKIRMRIDAAKEQAKVVNSVYKEGEVIHWMSVRSPDLVEFGRSLERRGYNTLGSIAFLTEDEFDPSLPDLLKNTLLMALAELRHDLYRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WQ03</accession>
    <name>A0A6G0WQ03_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_012946</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000164">
        <property type="protein sequence ID" value="KAF0729445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WQ03"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018036"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090114">
        <property type="term" value="P:COPII-coated vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF2">
        <property type="entry name" value="PROTEIN SEC13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="208"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0729445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="319" mass="34866" checksum="D7CFE24E7EA2093C" modified="2020-08-12" version="1">MATQPTHRVETEHVDMIYDIKLDYHSQRIASCSSDRTVRIYEAKQSAPSTLVACLDVPCEGPLWRVAWSHPKFNVLAASTQCGKIAFYRNKAPAGAPEAWGLLSVHQTRSSSINSIEFAPHEYGLVIAAASADGVVSVVTMTQAGWVTTSTIQDNDVGCLGVSWAPYNSLGGQGMKRLVVGGCDSKVKIWSLVDGDSSQTWQQLEALPHGHNDWVRDVVWAPNAGMPCNTIASCSDDRTVVIWTQIEQNGAWTSQLLHTFRSPVYRLSWSIAGQVLSVASGEDQVTLWKLAQQPDQTWKWSQVSSISEAGATATVIETY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WQT5</accession>
    <name>A0A6G0WQT5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_012644</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000161">
        <property type="protein sequence ID" value="KAF0729753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WQT5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008407"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0729753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="34638" checksum="66380F1E1B18FB37" modified="2020-08-12" version="1">MPQSHRFPVRQDFFKCPPLSPVEIFQYKQMATKCVLKVIAKANMANPAYEWTLASDEIDFKLYKGRSTASSALHCGQIEVVGTVDEVVELFRTDTTEQARFYCQRTQRNLVDAVNLYTILAPTAETPHDKIQIKWIVGKSTLSGLFKQRDFCCLEATQELQIEGRRMWVRAYKSIELDCCPDFKSTLGLVRGSINGSGHVFIESKERSGYLSMSYVNDFTVNGSAPDWAAEHASQSRCRNVLDIDRFLRENRLNQTPFLPPTEWDPPSKWHSCHVCEKKFGMLLKKTNCTKCGHVSFNLFIGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WSH9</accession>
    <name>A0A6G0WSH9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carboxypeptidase</fullName>
            <ecNumber evidence="2">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_012142</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="2"/>
    <dbReference type="EMBL" id="VJMJ01000154">
        <property type="protein sequence ID" value="KAF0730442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WSH9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015948"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF201">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026379234" description="Carboxypeptidase" evidence="2">
        <location>
            <begin position="17"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="486"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0730442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="517" mass="58059" checksum="7AAA7844354DF955" modified="2020-08-12" version="1">MATHLVWLTLAAAVAAIDHQIHTLPGYADKRPIDFNQYAGHLALPSNGQKMFYWLIESENDPTNDPLVLWLNGGPGCSSLGGFFTELGPFVVQSDLSVKRNKYAWNRKANMVFLESPAGVGFSEPMLPDNEYNDDTTAARTREFLEQFLLAYPAYQHRPLFITGESYAGRYIPFLLTKLIEAPLETVNLRGYAIGNPSTNYIIDHNAYVDYYYSHGLLSMENYEAVKSACGHDVGRCVISPVNCTDACENALQEGILAINETALNPYYIYGDVCLLNNSQAYHLKYRHLRPLNRGRVGPCTDTFTQQYLRLPAVLEALHVTNNPSWTSCNDAVSNVYHKSDSSMELYPKILSKGLQALIYSGDADMVVNFLGTQRWISRDGLKLRIKTTWHAWFGPDKQLAGYTEEYDGLNFTTVKGAGHMVPAVRPLHALYMFECFVYGHDACASFDYPKDSLEYLSGEDVVAYDDDDDDDTKNFSPTGDQVIDWSLYGMFVVIVCVAIAAIAKKQLDRKRQYEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WST4</accession>
    <name>A0A6G0WST4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cysteine/serine-rich nuclear protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_011946</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000153">
        <property type="protein sequence ID" value="KAF0730523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WST4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015890"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031972">
        <property type="entry name" value="CSRNP_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16019">
        <property type="entry name" value="CSRNP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cysteine/serine-rich nuclear protein N-terminal" evidence="2">
        <location>
            <begin position="32"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0730523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="152" mass="17332" checksum="FEBE2F5FCE1C59E7" modified="2020-08-12" version="1">MVSTTVIKTPGLEQTTLERVEMQEAAPDPARRAKRVSFTTATTYVFPLEYGGSAVPKEHGPPIGLAKTHSHVECTTIKNVKSKRGRVRKFDHVERMLLLQQLASYSRKEVAMFCFDAIAIRRSRIETEDDDENEESNEDLAEREPKRRKTLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WT97</accession>
    <name>A0A6G0WT97_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase C1A papain C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_012085</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000153">
        <property type="protein sequence ID" value="KAF0730666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WT97"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006838"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026022214" description="Peptidase C1A papain C-terminal domain-containing protein" evidence="4">
        <location>
            <begin position="18"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="5">
        <location>
            <begin position="138"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="224"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="227"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0730666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="251" mass="26689" checksum="EB7D966929DA2FCD" modified="2020-08-12" version="1">MKTSLLFLSTLSASALARVAYSSLSTDEQADVKQQLSKWKTLYAPLASKHGYVPESAIESVNVVDSHTDEELARFHNTLQDVAKAQENNPHAVFSPFNVFALLTQAEFDSKFKNTLAGQNVSAGQSVPAVESAATSAAAHSIDWSTSKCSSPVKNQGDCGDCWAFSAVGTSEFAHCIATGEKLDLSEQQVTNCDKASNGCNGGIASYGIDYVHNTGVLAIAIADQSTDGHREPSRTRDSIGPEKQPTRTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WTB3</accession>
    <name>A0A6G0WTB3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_012084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000153">
        <property type="protein sequence ID" value="KAF0730665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WTB3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011708"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009836">
        <property type="entry name" value="GRDP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34365">
        <property type="entry name" value="ENOLASE (DUF1399)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34365:SF7">
        <property type="entry name" value="GLYCINE-RICH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07173">
        <property type="entry name" value="GRDP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="533"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="618"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="629"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0730665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="666" mass="73008" checksum="C425962D26DA3FCC" modified="2020-08-12" version="1">MGASQSRDFLIDFHVVTSPNLDAEPLAVEWCRCSVKEQTLELTMDDGKSPPKTLDVRHVHINQTDGYRYELRCKEELVAVLLSPSRSHLAAFLRVLDLASASKKWTLPPTTPQTALFGVAVAIAETHAAKPVHDLVVSNMTVAKVQAHLAKMQAMYKALTTCNSKEDVYTMLLELEAAYVADKETANFAHVVHKLHPRQYEQDQERATTASQLKKSLRDIFQSCPSCEKALPIAAMYAVHMQRQTVECPHCATPLSYEAFHVAQLIDMGKIHWCSAATASTDAIECVLKLPNNSTHYVSLKWFIDEVKRRGLAEGINLSAEDKTRWQDHIDASLGEVAGSFSLDLVHAMARQLSFLLKVCSHRDYWSQRQVAAAAMVRYHKFMHLMRTRPKTMLVPTVDIDLVWHAHQCFPKDYALFCHGLVRKLVDHDDTIKGGDLQAGYATTFATWAHVFDEPYSSFAPTQPREHSDETPWRLPSRDCRFVGVDEMLPIDDRGGVFVSVIGTPVFDGRVIPTDSKQAKVVQTMEMAPIARRCKIDWTEPPPPPAKSTTEPKKKRPVKPQYYEPLPYVSPTSPPTAVTRPPPTYIPMYTPPTVDSQLYVSTSIQGASDPYGTNTSFDYGFSSSNDSGGDSGGGGGDSGGGGDSGGGGDSGGGGCGGCCGGGCGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WTK7</accession>
    <name>A0A6G0WTK7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_011880</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000151">
        <property type="protein sequence ID" value="KAF0730771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WTK7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010358"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021475">
        <property type="entry name" value="Pants/Emi1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF4">
        <property type="entry name" value="SECRETORY 24CD, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11326">
        <property type="entry name" value="PANTS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="6">
        <location>
            <begin position="551"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="7">
        <location>
            <begin position="629"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="9">
        <location>
            <begin position="874"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="8">
        <location>
            <begin position="970"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="5">
        <location>
            <begin position="1111"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="141"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="146"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="220"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="258"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="369"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="393"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="438"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0730771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1244" mass="134192" checksum="A8085BCC44FAC986" modified="2020-08-12" version="1">MSSEETPVKDANRLDLSCSAVLDVAFTCVTAKHQARYFYEMGEVDSCKGRWADIWRCFRANQMDKDKATEYLKGSHLDPNAKQHVASVWTLKETPGCLRNLTEILYEIRSILSIFQEKPVENDIHNSTNHAGTTHLAQMAEQGFPRGPPSYNAPPGGFPRGPPSHLQHQQQQPQQPPQGPLGGGGGGFPPSQQFQPPPRSIGGMPQNPPPGVQQAPRSFGGTQQIPGPGLQQTPPPGMQQPPRSLGGMQQMPPPGIQQPPRSTGGFQQNPPPFGQQQQLQQQQYPPRGPPAPGALGGVQAPPPQGFQGAPQPFPRGPPGPQQYQQSGPPPPGGLHQNAPGIPPPQGQQSHLMRPPGNFQQGPPAGYPQGGPPPAGFPQGGPPPAGYPQGNVGGPPPPGASPFPPPQPGNPNAPVFTPGPPFHQRPDAVGPNGVVGGAPPAPTPKPAPAPVVSAPRIDPTQIPRPLARQEVVTYVAKGATLTLPPPATSKYICIDEGCASPRFIRPTLNHVPESKDLLGQSALPLATVVCPLAKLHPGELAIPLVDFGAGGPLRCSRCKAYINCFTKFVNGGRSFACNICGMENETPREYYCAVDQMGKRRDVQERPELSRGSVEFLVPPVYSVRPAQEVIVVFCLDVSVFAFQSNLVASIVAALPAALQTLQATSPAAKFGVVTFDAAVHYYRLDQEKISMCVCPDVDDPAAPLPANAWLLPVQSPNAMDKIHELQDLIVTLFGPAAKNQAASGAAVTSVVDSLQVSGGRICLFHAGPPRLGVGKITKEEAASSYGTTKEVELYVGRGGVHAHYEELARQSAKSFISIDVCSVANPYSDLAEVSRLAELTGGYVVHLPQFEKDKLEHLQYMTRLLSHWLGKEKGMEAVLKVRVSSGLRVDTIYGSFMPSAASDDEVNIALLDQDTAVGVTFVHDGRLQGEHMYIQVALLYTRVDGLRTVRVHNLALPVANLVTNVFRHADLDATCAIWQRMAVKTIRDKSIMSGNGQAVKERLIDDCVQVLTNYRKHCATNSSSGQLILPESLKLLPLYTLASLKSRPLRNNLTGQQARGIIDVRADERVMLLACLNTFPVEHAVSAVYPKMYALHDLTEDVGTLDAQGEMILPTPLPPTAEKLEENGLFLLHASTFLYLFIGAKTNPTLLEEVFGLSHIDTSEQSVNLVGPGDQTGVLRQQIQAVIAHLQMQSPVPVPLEIMTKSDWRSNRFLSALVEDRTRNEVSYVEFLCQVHKKIQYKMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WTP8</accession>
    <name>A0A6G0WTP8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_011758</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000149">
        <property type="protein sequence ID" value="KAF0730876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012837"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070478">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000354">
        <property type="entry name" value="ATP-dependent RNA helicase SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000011">
        <property type="entry name" value="DEAD/DEAH box RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000447">
        <property type="entry name" value="helicase SKI2W isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000001">
        <property type="entry name" value="Ski2 ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048392">
        <property type="entry name" value="MTR4-like_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040801">
        <property type="entry name" value="Ski2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17911">
        <property type="entry name" value="Ski2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="397"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="632"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="303"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="594"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0730876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1309" mass="144843" checksum="B29A7FB53C802C84" modified="2020-08-12" version="1">MDVLDELDQLLAQERTQATPPASYAVHLSSYTSQEPLLVPHTKPAHPLTLPLPLVPPPPVQSKDVSAEEILARVSLDEASAFLWQGEPNRTLIEIPLSINRMDIKPVKTTMVLQPTDLSYAYESVSVDAKTMAETSNLMLRKPTQLQDYARGKIGNVPFTPGGDSLVQSSPADESAAIGRPVKKSSTEELVPLALSSTWEDELDALLLRAPGLPHGFTRDDIDRLAGTSTEEPLESITQETVGVNPSYLLKPYYDVVTDQDSLKAVTRTIADEKALLAMEAKSNNTISIESLLASAADDDDLGFQVDDEEDNATPQDESPGPQKPLAFEDSGNPVPEFDEIELSLDLEPSTSGSNTSGPVLEWASKAEVDVSDFHTKIPDMALKFPFELDSFQKQAIVHLENHECVFIAAHTSAGKTVVAEYAIAMSQKHMTRTVYTSPIKALSNQKYRDFRTKFGVDNVGLITGDVSINPEASCLVMTTEILRSMLYRGADVIRDIEWVIFDEIHYLNDSERGVVWEEVIIMLPEHVSMVFLSATTPNTFEFSDWIGRTKQKKIHVISTTKRPVPLGHHLYAGGEIIPIVDNSNQFLTNNHAKANQKCKPKETKTAATRGGAVAKGGRGGGDKADWTKLVRLLQEKELLPVVVFAFSKRLCEESANRLAGLDLSSSSERSEIHVFCAASISRLQGSDQQLPQVLQVRDMLLRGIGVHHGGLLPILKEMVEILFGRGLVKVLFSTETFAMGVNMPARTVVFNGTRKHDGKAFRDLLPGEYTQMAGRAGRRGLDAIGTVIIACWGEVTDATSLRRMLLGEPTKLESQFRLTYNMILNLLRVEDMTVEDMIKRSFSEFRTQKALASKNIPHAIQKAKKVLAHLEQELEQTHGGQLDLHEVQQFYNLTQSTKRLEQQLVQMILGSKHSSAALCIGRVVIISTFGLSDALGIVLQVNKTTVKSFVVLALCPTSFAPPEAKQADAPRGRSEGLKVGDSGSLLGKRYIVMELPESCVELMTKHKGSTGVRNLLEVNDVSVLSRAIELLVDLEPKIKYSLDPRTDLKMSDIDAVEVYREIQYQYSLMEGNICFNSPFLLPVLSQFAKIAKLRDYLTAMTAALSNHSLSLFPDFQQRLKVLTRLGYIADDNTVQVKGRVACEVNTCEELILTEIIFENVLANLEPEEIVSVLSALIFQEKTQNEITLTPRLVEAQKTVQAIAASLGLIQLESHLEIDPNEYVKSTLNFGLMEVVYEWSRGMPFKSICDLTDVPEGSIVRCITRLDEVCREVRNAARVIGDPRLYRKMEIASESIKRDVVFATSLYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WTV3</accession>
    <name>A0A6G0WTV3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_011759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000149">
        <property type="protein sequence ID" value="KAF0730877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WTV3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012836"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0730877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="344" mass="37768" checksum="E7220FEBC237827F" modified="2020-08-12" version="1">MGFHRAKLIVAELVHKCIDNERRIRRLLFVDTRRLQDSSSSSSLSIGAIIGIVVGVLVLVVIACICIRRARLESRRKQMQKRVDLAFNEGAQQQKLGLQETLLVPTARLSQAPHGEVPTPIEHVVGSTDSDDFVIMGGNKATGAAGAPDFAKMNKVGMNVKTNVKPPLPPSKLGVLEDIHSAASGDFIASYVSDDIAILQSRRCHAAHTFLFCGQCLLLSGVLPVYLFLASNLHSRIFPCLDCCTDVRHYVWSSTSFVSQTLFWWTHRAIGHGFSSFQNPLANEKHQAACLLYLDRSNRCFDPSLVQEPLGTMPLLETTTELGIFDLAVPTCRSEASVPRCASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WUK7</accession>
    <name>A0A6G0WUK7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_011479</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000146">
        <property type="protein sequence ID" value="KAF0731218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WUK7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009805"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052658">
        <property type="entry name" value="TPR-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15544">
        <property type="entry name" value="OSMOSIS RESPONSIVE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15544:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="43"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="111"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="147"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0731218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="199" mass="22535" checksum="DDBC8042EEFF51F2" modified="2020-08-12" version="1">MALWFGTKRRKLESMTEYEYADLDEQKPAPPVLMTLEDTAQKVKRLQAEGNTLAEAGRFRAAIERWQQGLTFDPNDGVLCELIAQAHMATDEYFLGIQAATRATELCPTWGDAYATLAHCQFNFGELELAYASLSKALDLETDSMRRQEIADELKEIETLCERQREKLAQASKVHFDDADAAQVHECKTNLARRSIAWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WUS5</accession>
    <name>A0A6G0WUS5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_011476</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000146">
        <property type="protein sequence ID" value="KAF0731215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WUS5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009808"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="88"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="131"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="174"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="216"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="259"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="301"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="343"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="385"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0731215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="422" mass="45851" checksum="B6DF02D5A75F67EE" modified="2020-08-12" version="1">MRLQQICVRYYPPGLRLKARRANGEEHVMTLDLLGLGPETNVRLLVAQLIEKESLLTKAHTHRLYDILHALIDRQCPRDDEWTLAKTFQAHNQPMTNFAISKTASLVATASYDKTAKLWRPSSSQDDKRILRGHDGVVYSIALNTPYATIAATGSFDKTCRLWDTASGACKHVLSGHSGEIVHVGFSPSGAHVGSCSMDCTATIWDVSTGQATWDLTGHTSEVSSLAFDRANTSLMATGSCDTSVRLWDARYGACFRSLQGHADDIATTSFNYAGNLVLTASSDGTANVWDVASGKAVFQLRDHVGQVTDACFNATGSLMATAGVDGHIYIYDTLTAQRRCQLLGHDGEVMQIGFSRQGSRLVSAGVDTTARVWNVQTGECLQVLHGHNDHVVSAQFAYDGSMIVTGGKDNMVRMWAADKTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WV50</accession>
    <name>A0A6G0WV50_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_011290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000143">
        <property type="protein sequence ID" value="KAF0731387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WV50"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004729"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0731387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="256" mass="29028" checksum="2CD819F0CE0A021C" modified="2020-08-12" version="1">MSDMEDEISAFGAMDLEDSQTDGNETPSLYVDNERQRIQAVVDAYAYDEPALIDVLCTDFGCFGPYFEGHVYQTMKEYMGGDSLSLEDAVARIAEFIEEFVAAGDEEHAMAWMLDLEYAFLQFAKRTPPARHAKLLQLYKKLAARPYPPQMALWSGRFSVDGAASEILNDVMREKDYTDGSDLDCFVPAAAAWVRVLGIRLKSKRIMESDPDSLKTGWDFWKSRFEEVAQHPGVNEETRDIANDTVVLMNNLDRMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WXE7</accession>
    <name>A0A6G0WXE7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Homologous recombination OB-fold protein OB-fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_010805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000137">
        <property type="protein sequence ID" value="KAF0732155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WXE7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001097"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028045">
        <property type="entry name" value="HROB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058570">
        <property type="entry name" value="HROB_OB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14523:SF1">
        <property type="entry name" value="HOMOLOGOUS RECOMBINATION OB-FOLD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14523">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN C17ORF53 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15072">
        <property type="entry name" value="HROB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homologous recombination OB-fold protein OB-fold" evidence="2">
        <location>
            <begin position="113"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="258"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0732155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="401" mass="43729" checksum="87D1651CE2D5D7F3" modified="2020-08-12" version="1">MIQRYLWMVSDVSVVLLNTDLTGVPVRKINGPLSDLWKKMSKSVHQHPNNQRMESSEERVEFESGPWIEMCRFMDWGVTEGQINGGLDLSKLPINTEQIATGFHTSGTVKEDFLVLIKSSKYVDDEIVATFHDPLGCIDGYFHRDVVEAIGAALVVGTGLILRNVTVFVPVERRQQYLNICRGNVIEEVTAFNSEQPTWVDSLSILEDPEGPTTTTADLLAMTQRQVIIQSHAQRAPPKRKWAWKSFAPKKKKTQQQEAEPSPTTSESPSPAMLPTPPSAKPSTLKSRSPARTPIAMTKKSVVINDTPPSSSSRAKPPTIPSPRAIIPSGTPSTPTPAPAQSSRPTTAPSNPISSSLAKPKAVLAKPGVSNATSAAQIIKPSMAPDEVTKAIDDVLNEDDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WYD2</accession>
    <name>A0A6G0WYD2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RanBP-type and C3HC4-type zinc finger-containing protein 1</fullName>
            <ecNumber evidence="7">2.3.2.27</ecNumber>
            <ecNumber evidence="6">2.3.2.31</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18 19">RING-type E3 ubiquitin transferase RAD18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">Ae201684_010414</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 26">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RAD18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="7"/>
    <dbReference type="EC" id="2.3.2.31" evidence="6"/>
    <dbReference type="EMBL" id="VJMJ01000131">
        <property type="protein sequence ID" value="KAF0732519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WYD2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021577"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097505">
        <property type="term" value="C:Rad6-Rad18 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006301">
        <property type="term" value="P:DNA damage tolerance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000172">
        <property type="entry name" value="E3 ubiquitin-protein ligase RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039577">
        <property type="entry name" value="Rad18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14134">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14134:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <keyword evidence="12 20" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="22">
        <location>
            <begin position="26"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="23">
        <location>
            <begin position="341"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="21">
        <location>
            <begin position="372"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00017887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00082369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAF0732519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="384" mass="42945" checksum="5A0D26928348630B" modified="2020-08-12" version="1">MDAVDDEWVWPNELKEARLMETLLRCQVCGEFFTGPVLVRECRHTFCSECIRKHLLARGTNGNCPECKCSCSSSDLIPNRPLEQLVDLFRQLKPKVLQLAAGVDLQDIDSTSEKKTKRKAKNAETITRLPTVSYNVMKDKQIQQLLDKAGLGAILPTAKDNMIACHKEFIMLWNAQLDTMNPKSPNQVRSEVIEAFRLRQQEKMNKASTKKALGLRHDEPLENALHKSAAFQDNFRKLAAQAKAKMNGEPAKTQSASPAKVPEVIDVATVAAAENNDARDTLPNGELRYIPRDPTAGAWRHLYSTTLDKPLFVNSTTHEVTDEVPPSFAKQPSLPVKRPSEPSEWTCGVCTLLNTPLMDRCEACGTANPRPFRPKRSKQSKLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WYM8</accession>
    <name>A0A6G0WYM8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CBM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_010329</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000130">
        <property type="protein sequence ID" value="KAF0732621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WYM8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013712"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026158881" description="CBM1 domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="4">
        <location>
            <begin position="331"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="4">
        <location>
            <begin position="374"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="188"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="188"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="213"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0732621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="412" mass="44401" checksum="3787CC7184C4B9BF" modified="2020-08-12" version="1">MFTTIATVLFALAATVHGHGNLVDPFPDFINPNSDITQYCGTVDGPKVLPGSQYNTSPEDNTKAFTKNFKASSFKTLKDFVIGNPNQCGTCGLTKENGAKKTLNADGNVYWGHGQEGFTPSHEGPCELWCDDIQVFQNDNCARNVKNGTMPIDTSKCNGASRLTAYWLALHSPSWQIYVNCVSLAGGAAPSPSSPKPSSAPTMKPTNSPITPTPSEDPYTPYPSESPYTPTPSDDPYTPYPSESPYTPTPSEDPYTPYPSESPYTPTPSDEPYTPYPSDSPSTPYPSESPYTPTPSDEPYTPYPSDSPSTPYPSESPDTPSPATPSPPSNGQVQGYYQCGGKTYNGPTQCASGFHCNKWNEWYSQCVPNESADVGVPTWGQCGGSGFNGSTNCQSTDVCKVRNEWYSQCVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WZQ8</accession>
    <name>A0A6G0WZQ8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_009915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000126">
        <property type="protein sequence ID" value="KAF0733093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WZQ8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019116"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026141494" description="Apple domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="2">
        <location>
            <begin position="32"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0733093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="101" mass="11332" checksum="77AC03F8179BA425" modified="2020-08-12" version="1">MKTAMTLVLVALYAVSASPLDTFSCNPLLDDVDYKSKLSVKTNQSSAEDCCKDCRNREAFCDFFVWTTENDGTCELKRFKFPLTKVHRPGVRSSVIRGVTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WZZ4</accession>
    <name>A0A6G0WZZ4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_009928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000126">
        <property type="protein sequence ID" value="KAF0733106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WZZ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011240"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0733106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="375" mass="41241" checksum="ED7AD44124D89359" modified="2020-08-12" version="1">MTTVHEMLVAMDTRLNRVLEAIELLPQRICQNLQSSKESSSSSKSPTITMTIQEFTQAVLDAASGLQHKEHSPLTSSISIATLCINQAQDQPVPKTQDDPTSIEPTKLGFSTPQLEDPSGESHDSHLTLSLTSPALPLDAQPERLLSALPTTTSTTHEAEPKPVQEISPSSSQSSRLDPKPKKRKMAPSYSQRDISAASMLTSTTPVPQTSSAQTAQCLIAGTGTFQWTDGQVHRTPETWQCPATTCKALWTCWFHGDPINQVGPFHLLQDSDVRSPKSRRLLQRGRAVMSTLVQTALSHNLAASTDALTALSAVELTDVFDKTFELFLDKVDDGALRRRGFEKIRWDQIIYYMYGSVFELMTTQATPRASNTFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X0Q5</accession>
    <name>A0A6G0X0Q5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_009712</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000122">
        <property type="protein sequence ID" value="KAF0733469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X0Q5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012408"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07990">
        <property type="entry name" value="LPLAT_LCLAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032098">
        <property type="entry name" value="Acyltransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983:SF16">
        <property type="entry name" value="LYSOCARDIOLIPIN ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16076">
        <property type="entry name" value="Acyltransf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="320"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="5">
        <location>
            <begin position="91"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0733469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="368" mass="42189" checksum="F483581CF67B4540" modified="2020-08-12" version="1">MQVSWKGVCFVGALVLTAISAVFMLLTPAFLILYVFGKRGEVLFMYVQQLVQGMWLGNVAILLEQWHGMNTEIYIIGDKSRLECIASSERAVWISNHRTRIDWMLLWSLGLRTNTLHHLKIILKNGLRSVPVFGWAMQMFQFIFLSRDWKQDEKYLTTLLTHLGATRPNSSYLLFPEGTDLSPSNVEKSNAFAVAKGQVPRKYSLYPRTTGWNHIFPLVRDNVDAVYDLTMCYIDHAPNDRPSEASLLSGRMPSTIKILLERIPIETIPLDAASLRIWMEERFTAKEAILEAWHTKQTLPQDAQRILDHDILQRAHLVQAFWILLCTLCFMTLYEYVIVRICGILVILGHTIFTGRGGSDGYLLNRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X137</accession>
    <name>A0A6G0X137_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_009526</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000121">
        <property type="protein sequence ID" value="KAF0733591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X137"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003106"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14003">
        <property type="entry name" value="STKc_AMPK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021789">
        <property type="entry name" value="KHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51490">
        <property type="entry name" value="KHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KHA" evidence="6">
        <location>
            <begin position="19"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="112"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="419"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="447"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="462"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="503"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="563"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0733591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="577" mass="63234" checksum="42DB64DDD9E4EEE1" modified="2020-08-12" version="1">MADFGDLDDFNEHEVQGRPIKAYRNGCFENPKTLFVQMHWSWDDFLCSCSQRLEMVPMASRVFNSDGVEIDDLMCIEEGDMLFFSTGAPFKIPGHDDKATEEIGAGGVVGGYRVTTLLGRGGFGEVRLGVHQLTNEKVALKFILKSEMGSLGDVERTTTEIQCLTALNHPSIIKLIRVFNEPNHVVLVFELLEGGDLFHHLVHLPPGGLSEEDGALVFSQILAGVGYAHNQHICHRDLKLENILLQNKNDLNSVKIADFGLSDFYRPGAMAKTTCGSISYLPPEVFRGTSNAGPPLDVWSLGVILFAIVCGRLPFEGSDLKGKNRPRENVIRNRIMRAQYKIDEHLSPDVTDLINKMLKLDPIERATIPEIFSHPWIRGMAGSVGLDSMTASPMRDGDDDLIDDCESFTLKKDVEVASADEDKAKGGSVSAAPLVPPLNHVAPQSPPSSVVSHSHSNPNTKRSVRHDIQKHKSPRTPLSTSTAPAGFTIPPINTAATMMPKTGSDKHVDKHAPALSPTNGKRGSHSSKDPSLTPKESKDKSRRVPPVHPMEDRSATIKSRRKASVDKHSDATLEPIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X318</accession>
    <name>A0A6G0X318_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_009118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000117">
        <property type="protein sequence ID" value="KAF0734257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X318"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002204"/>
    <dbReference type="OrthoDB" id="61379at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0734257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="198" mass="22126" checksum="76156EBC0B835122" modified="2020-08-12" version="1">MTTSKPLPLISPGNASHHIFRLIHPMIGLSGFVDWRMAYLASKNPFIPHQYHHVSSNFLEGLASVMWGIGGIIQYEIEVPKFNQNAKSTHSILGLVTRHRLDKTFQTSRRFYLASYGGLVGLTGHHAVFGYMAYRRHDMKRANAHVAAGSSAACYAYLWRSIFLGSKVATMGVSHFAATACILTVWLTESDKILKQIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X340</accession>
    <name>A0A6G0X340_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_009117</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000117">
        <property type="protein sequence ID" value="KAF0734256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X340"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002203"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05123">
        <property type="entry name" value="STKc_AGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000715">
        <property type="entry name" value="AGC protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000008">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053858">
        <property type="entry name" value="Arb2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045270">
        <property type="entry name" value="STKc_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22749">
        <property type="entry name" value="Arb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="334"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="9">
        <location>
            <begin position="596"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0734256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="689" mass="78393" checksum="E05238C01278C725" modified="2020-08-12" version="1">MLREREMELALQQIVYEEQSKMKALGFVEAFIGTNEAKCSIFLSSHWERVARLLLIIVSGNGIQPGIWSRSLVMEPQDPRQYYRSGSMLPYLHKALTLGYGVIVTNPSTNMVITNHGDKIPIPYSSTPEEHVRYVWEAFAMQSRCHQIYIAAYGRGGVLAKHLLTTQPTLRHKLAAIAFIESSHRVSAEDPEDVRTIISTRAINWQRSTEDAGRQLPDCAQLGCLSLSAGEPQVTRSSGEQRSTNTAWTIGASMETVFAFFDSARGYDLAEEQKYMEQMYGAQPHFEPPPLYSQPPRQDQHDDGDMVIENIIDTKSRVTSRSMVISTSMSVTDFDLLSVVGKGAYGKVFLAKKKAGRNAGRVYAMKVLRKDDVFKKKQVEHTKSEQRILKHVEHPFVVHLRYAFQSDYKLYLVMDYYHGGSLFVHLKKLKSFPEQRARFYAAELVLAIAHLHSLHIMYRDLKLENILMDADGHVAITDFGLSKEDDEGSTFVGTPEYLAPELLSSQRTATSYGKSVDWWSYGVLVYEMIRGQTPFYDKNRRSMFQNILTKEPTFNTELFSPTATHFLQSLLVKNPAQRMGCGPHGPVEIMQHEWFADIDWQALMDRRLEPPFRPNVNQTQDALRYVPASFLQQDVADSPVMPSMISGSAPGRHTMHFDDFSYMGSDIMGSRRTSLFRESDFRMDFDDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X3G5</accession>
    <name>A0A6G0X3G5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_008900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000114">
        <property type="protein sequence ID" value="KAF0734440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X3G5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011028"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00635">
        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50202">
        <property type="entry name" value="MSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MSP" evidence="1">
        <location>
            <begin position="23"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0734440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="154" mass="16930" checksum="F878D264D78C1ED9" modified="2020-08-12" version="1">MGNAVPAKVSCSSTRTLAKQPLNVVVNPSARLAFTLVRGLSAMAVLNLTNQSDTHHVAFRVRSTHKRYHIQSGDGILGPRRAMAVAVLVAPEECERWTKESPNEPDTFVIEMTNVPKSVATSTVRWEAIESTAIHAVKMEAQWSSWSHEDDPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X5U6</accession>
    <name>A0A6G0X5U6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_008160</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000100">
        <property type="protein sequence ID" value="KAF0735243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X5U6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004267"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15571">
        <property type="entry name" value="ePHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15492">
        <property type="entry name" value="PHD_BRPF_JADE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050701">
        <property type="entry name" value="Histone_Mod_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793:SF107">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793">
        <property type="entry name" value="PHD FINGER PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13831">
        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="89"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="7">
        <location>
            <begin position="148"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="436"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="642"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="439"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="642"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0735243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="695" mass="78816" checksum="66821883952DF6DB" modified="2020-08-12" version="1">MDKDAKHSQEETDAAMPKKDDIPPEERLTLFRETSIPRRRLMRPTHRNNAVVTSIVKDIVDNAIDSDALPRIHVQKRVCVPDEDLCINEGWCSVCNGGESDAGDLIVYCGMCGIPVHQSCYGIPSIPKGDWHCQRCVALLETSQSPSSMICVICHRYGGAMKPLQRIQRVTTLPEWVHVLCVWWDHDVVVPNMQVMEPLQMVHPPMNNRQRICMLCNRNEGYLIQCHWNQCDCWFHAICARFGDANVIHRHRVDPKEHLGGGFLQVDIEEGQRAAFHGYCPRHATQYFCLDDLPAKLLASELLDDPKLVARVEKIRTSSPDPDIQLAALGKLLVKYAEQTMASIPSQQLLQIFADHLPQIYKTYPSTTIQLHDVLGASWIEKLHATFGRQTEDPFSFCLVCKDPLTQIDHCFYCTHDQRPHLQHWRCISRASMSSSVSRSKKKLKSSKAKPQLPPPETPSKEWPTYGNIVLQCGVCGAPMDTRAVAVSKTSDFQIQPYVETVAIYSHHGRFVNEVSPPTPKPPATTALPPSDRFRVERGLKLVTEVSKLIHQAVAYKQTADEAIYNDMLTQLSSLHEWIKPLDSYAAEKLGQVLETLTKKQGPGMATLKQFVRDYTKLIHAKHLRAQEKAVAEQKKRELDMVLESKRMEREQMDTEADRSLKDQMQKLKKQEKARERKRKLAKTPATAGKSPAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X5X1</accession>
    <name>A0A6G0X5X1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_008082</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000098">
        <property type="protein sequence ID" value="KAF0735390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X5X1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014117"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21343">
        <property type="entry name" value="DETHIOBIOTIN SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21343:SF10">
        <property type="entry name" value="DRTGG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13500">
        <property type="entry name" value="AAA_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="368"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0735390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="407" mass="43723" checksum="CB60C905CD224642" modified="2020-08-12" version="1">MKDHRVEKVQVVGDGSDFAAAEAFLEGLSFLHEFSLEAQSVPGASLEIHVIFSDLQVKSFTSVDTTVAFLRHVFEFSAIPPSLSSPSSSQAPSKTSSRALRLFIGGDKSQVGKSTVCLGLLGSLLELGYKPSELAYIKPATQCELPQLVSRFCEHYGIDARPIGPVVFYSGFTRSFLEQPNPTQASTDLLAQIVAAVDEISKDKRVVLIDGVGYPSVGSICGISNADVAAALSPISVVLVGKPGVGDAIDSFNLNATYFASKNVRVLGGIFNRLPTDGFYSLENCKLHVSRYFSAMTQGRQKAYGFIPDMPQLKEEAPPENETSSLPWTLIVDSLNTHVDVSTLVRDAEAVQTATPLLSDSRTTVTVEKSEVEMEPTPVDRLSPSSVWKPSRETIQAEARQAGAGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X615</accession>
    <name>A0A6G0X615_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_008224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000100">
        <property type="protein sequence ID" value="KAF0735312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X615"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019486"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13527">
        <property type="entry name" value="Acetyltransf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="119"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0735312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="194" mass="21740" checksum="30181A7E4670244C" modified="2020-08-12" version="1">MVNLTLVSRSLGRAFVNYPIMNFAFQGYTDAEQLQGLTALWYKVAAASSTYSGVVEVEDGNGAICWLPRNQYPLGLWKELKSGMITLPFQVGFRPLSRIVRHYHESEKYTLEHASANAGWICVVGVAPEGQGKGHCRRMMETAIDAMRAQGMDEIWLTTDKDVNVTIYKKLGFQVMTEKVISSSGVKSWTMKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X6X1</accession>
    <name>A0A6G0X6X1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_007730</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000093">
        <property type="protein sequence ID" value="KAF0735721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X6X1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013561"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001881">
        <property type="term" value="P:receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045188">
        <property type="entry name" value="Boi1/Boi2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22902:SF27">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22902">
        <property type="entry name" value="SESQUIPEDALIAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="26"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0735721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="177" mass="19877" checksum="33FFD6F6C4B7128C" modified="2020-08-12" version="1">MMGDKEELVRGREASDDDAVTTSYQTEELRGYLLKKTRNGKWQKRWFETNGCFLTYYKKQGQKLLAALNLPQVGEIVTLPEDTEDGPGLFSIELNERIYTIKAKNQDEAKLWVEALVWRQQGGLVTQDDLSHLDVPMNDEDALDTPIPTVLPPSTTTLDTTNEAAPRTGCAPCCVIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X7X7</accession>
    <name>A0A6G0X7X7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_007662</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000090">
        <property type="protein sequence ID" value="KAF0736076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X7X7"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0736076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="82" mass="8769" checksum="C4F2DFF5245EA122" modified="2020-08-12" version="1">MQQLLDGGVQDSINEDTFGKDTEQLRLFEIMRIQPVEVTILTAHKPLSTMAGPTKASTSIHADGFHATSALRGADGSTATIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X9X4</accession>
    <name>A0A6G0X9X4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_007150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000088">
        <property type="protein sequence ID" value="KAF0736703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X9X4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017222"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF440">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0736703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="30295" checksum="62921E0FC0BCE474" modified="2020-08-12" version="1">MMKTIHIRQEKFVLELLDRFHMTNCHPVQTPQVNGAVTTTDLAVDTRNVPYQNLIGALQYLVSATRPDIANTVRFLASHNHNHTQTHWRMAKRVLQYLKGSASLGLTFDGKKNTIPQAFSDADFANDLNDSKSISGMVITLAGAAVLFSSKKQSMVGHSTTEVEFIAAAEAAKSIVWLIELLHELKYDIKQSIPLHVDNQSAIQVARRSSAHDRTKHIRLRFHFIKDLVDEGMIEQRYINTKEQVADILTKSIVLAQFERLRFMLGMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XDK4</accession>
    <name>A0A6G0XDK4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mei2-like C-terminal RNA recognition motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_005833</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000077">
        <property type="protein sequence ID" value="KAF0738274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XDK4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018910"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12531">
        <property type="entry name" value="RRM3_MEI2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034454">
        <property type="entry name" value="MEI2-like_RRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007201">
        <property type="entry name" value="Mei2-like_Rrm_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23189">
        <property type="entry name" value="RNA RECOGNITION MOTIF-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22586">
        <property type="entry name" value="ANCHR-like_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04059">
        <property type="entry name" value="RRM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Mei2-like C-terminal RNA recognition motif" evidence="3">
        <location>
            <begin position="430"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0738274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="619" mass="69288" checksum="46F085190EB13B03" modified="2020-08-12" version="1">MDSSSRIEKSSAIIACDECGQVDATSTCLACELVYCHVCLEEVHRNGKLQSHIDNRCIQRMSNNQEEDAQSDLNTFEAWKTSDLWGSWNVFGERPTSQTSNHSWTNPAYDDSSSSSDDEPKASSFSSAFKSLALTHSVDPSFDFPSPVAATMTTAPAAWTRSVSQNELEDLFTALEMSRASRHVVVRSISRHLSSSEVSNISHIMHSFGEIAQYIPAFALHGLLVYSYFDLPAAVHAVQHYQTIRRDDPNSLSVAFCVAYEPPAMHNHAVVAVEVHAPLDSLPTTDEMIQFCTRFGSIARVTQAEYACAVFMVELSDTRDVGQAIVQLNRAKFGGQFSLSAQLAPLPLHVQKLVQSFRHAMDTQSQHSSLSFEPNLSSMSFHQPASDGFQPLFRRESAMATPPTTTAPPSSQESAFSLVLDRVSKGLDRRTTLMIRNIPNKYTQSMLLAEINENHQDDYDFFYLPIDFKNKCNMGYAFINFVTYDAIVPFYQAFNGQKWRNFNSEKVCAITYARLQGKAAMVARFQNSSVLEKHESYRPLVFKSSGPDKGMLEPFPAPRIVKPRAYVSPDHQDQPASMPFYHPSATTYNGGLDPRLYQEQHRAYHQGYVQPSKKPVLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XDP0</accession>
    <name>A0A6G0XDP0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_005856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000077">
        <property type="protein sequence ID" value="KAF0738298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XDP0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004234"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011171"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="84"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0738298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="458" mass="50805" checksum="D244FC7295B879FE" modified="2020-08-12" version="1">MVLPASTPSPDPALQEVVINHVSASLSTDQRRALDSPIRASELCAAIKTMRKNKLPGLDGWPVVFFQTAPEIFAAILCIVFEYQRKRHGCLLPHQRTSSITLLYKKGERNPGNYRPIALMPVEVKILSRVLAYRLSAVADTLVHPSQAGFEGRNLTDHIHLIQALQHKATRNNEEWYATFLDFAKAYDMVRWPFLFAVMSKMNIGPEFLDWVRLLYRNPEVHLLLNGAPGPTIRPNRGVKQGCPLSCLLFDLYLEPLGAMLRACPEAGIQIDDDTRLTGVYFADDSTLLSGSLESAEYQVDEIVGKFCAVSGAALNRTKCITLALNNNEEPIGRASTPSITLAASGQPIRFLGAYVGHRLPPNYHAQQINDKYLAAFAQWHSRARTIQGRRTLASSLILGLVWHVTAVTPIPAAMIETWQRILNNYIAGGKTAVDPKYRLPINSSWMCDKVLGLGIPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XDX4</accession>
    <name>A0A6G0XDX4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_005751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000075">
        <property type="protein sequence ID" value="KAF0738399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XDX4"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0738399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="133" mass="14632" checksum="B9A915E08556207C" modified="2020-08-12" version="1">MILSLCIFDRVSSHLSLCVSVAEHEGYRDTLIIFQDTRLVGSFAFVAIVVGVAAVKGDRGIIGFKASAPIVAARAVLFGFRTRSSATSRLTILVVVFLVLQFAANGHLQLLMAKWKMSSQWVSFLQHKYRACI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XE42</accession>
    <name>A0A6G0XE42_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_005700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000074">
        <property type="protein sequence ID" value="KAF0738470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XE42"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017720"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="171"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="171"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0738470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="344" mass="37961" checksum="F4CAAA3B1EAF583B" modified="2020-08-12" version="1">MPSKRSGKAKPPRSQSKQLPPQPDTMSAFQAVLDTATSELATELENHAQHVKDVFHGASFSLTDLPSLAHAAVDILANSQCLLRRSTREWIQDSKTRQEFITDAHPLLLRTSQQLAANVLATAQATQRVAVLEEQVGAQASLIQLQESRLDAQGRQIDALEAQLEVLSKAQQRGSPLSKTTVSAGGHHASFDLGSPIDTPPSSPVERIRAAIRASAAVNSNETATPSAGQDDNLFSAPISPVVDDSNDSDYEDEVVIVENPDRSKKYWVYEDETLAEVQRYRQAMKAGLCDHRYQGPDDRHCAKPWAECIERRLGNHSDQCRWITTKHMARCKASIKQCSQHRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XE47</accession>
    <name>A0A6G0XE47_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_005664</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000074">
        <property type="protein sequence ID" value="KAF0738433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XE47"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014643"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0738433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="200" mass="21955" checksum="915FF57D6D07C3A7" modified="2020-08-12" version="1">MDGGKLVWFSLDYFGLLWNKWDPKGYCIPRKIAGCELIVEKIPHGELGHRRVVEQWIDLQRLNLSSGFLGELVDVKATESALPSVFGTTWRFAKPAAAMTDTFATGMGLFVAIFHRACPFQVWNGMARAVIAHTLIQRAVFKLTLASAAVTDTQPSSIALVCAVRDKTARSSPVKAVFPRARQDGAIVVVKQTLGLHCAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XE79</accession>
    <name>A0A6G0XE79_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_005662</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000074">
        <property type="protein sequence ID" value="KAF0738431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XE79"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005395"/>
    <dbReference type="OrthoDB" id="10270990at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827:SF1">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0738431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="228" mass="25747" checksum="1E576102AD04FC8D" modified="2020-08-12" version="1">MTTKSTVCFFNDCENPVVPGSWKCLFHRRRSRCLVADCANQVYARSLCVRHGGRRQCQHDNCTMNQRVGNFCSRHATAGLKKMCAEPGCGKQAHARGRCVRHGGGRLCKTPNCIMHARHGAYCSHHIPVEISKFDFEPVDQNHRRESMMALDSSILMEILQDQVVGKFNCIDLDVKPPLDHWNTVPKPMVGHIDDILDTLGNIAEFPIKQEVCTVEYLLPPRTTSFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XF66</accession>
    <name>A0A6G0XF66_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_005350</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000070">
        <property type="protein sequence ID" value="KAF0738731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XF66"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000299"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052355">
        <property type="entry name" value="CENP-V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620:SF1">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620">
        <property type="entry name" value="CENTROMERE PROTEIN V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="4">
        <location>
            <begin position="8"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0738731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="135" mass="14976" checksum="F538C0ED892FED12" modified="2020-08-12" version="1">MSSAKVVHRGACHCKRVRFEFDAETELVAIDCNCSICLMKRNVHTIIPSSCFRLLEGDDVLTTYTFNTHKAQHKFCSVCGVQPFYIPRSNPDGVAITIACITPGTVSRFDIQTYDGQNWEAAYAASDIAKYSKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XF68</accession>
    <name>A0A6G0XF68_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_005514</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000070">
        <property type="protein sequence ID" value="KAF0738906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XF68"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013573"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12999:SF7">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 15B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12999">
        <property type="entry name" value="ZINC FINGER RAN-BINDING DOMAIN-CONTAINING PROTEIN 2 ZRANB2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="198"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="287"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="296"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0738906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="336" mass="37421" checksum="89149538AE39847C" modified="2020-08-12" version="1">MQRGRSEERGRRDDRGPPRDRSRGRDDQDGGNRHRDDRDRGGYQDRPSHQDRPSYQDRQSHQDRSSYQDRPSHQDRSSYNDRPPAHQDRPSYQDRPSHQDRGNDRDRGSYQDRGSDRERSVNQDRSGERGDRRYNDRDDRSSHGGRDGGRDSYSRDNSRGHYGDGGSSSYGHSSSPPPAEPTGPWDPKAEAEKDPNWARIYVSNLPDDITVDELQGIFGGLGVIAKEKQKRGYKDQWPWKIKIYTNDDGTSKGDAVITFEDANAARTAPGFFNGSDIRGKTITVELAGKPEPPVGGWTGGQGGRGGRGGRGGRGSGGRGYGGGRGGGRGDSRYRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XGL7</accession>
    <name>A0A6G0XGL7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3'-5' exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_004955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000064">
        <property type="protein sequence ID" value="KAF0739386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XGL7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016164"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052408">
        <property type="entry name" value="Exonuclease_MUT-7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47765">
        <property type="entry name" value="3'-5' EXONUCLEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47765:SF2">
        <property type="entry name" value="EXONUCLEASE MUT-7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="PPR" evidence="1">
        <location>
            <begin position="108"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="3'-5' exonuclease" evidence="2">
        <location>
            <begin position="865"/>
            <end position="1046"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0739386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1055" mass="119434" checksum="04E530C28B6FA2A4" modified="2020-08-12" version="1">MSHRWEDDEVTRDIVAALQDGTTTVETRVLLKPIFRWAKREPEKAHDYVRWLLVLYTHGDPSRNISVQPTLQADYAINTLITASQRCGKGFEAERAFNFLPEFEFVPDVFAYTALIDVLGRCGQADMALQRYQEMLRSSVEPNIVTFTTVLRVLGMSTTVNARYSLEVLDRAKSQGAVDPSLYTEALDMCAKRLDFDLATEILRLRRDDGITELLVERTIYAMARALRKTSFEIVDKWLDEGLIHAGDKDAWTFKNRADHQSADGKSSTVGLLSYETPSSVRQSVIEQDIQKLMERTTRNVWPTRMDFETLIHQCRKRKWKEEVGLVFDAMRQVSTDGWHHGGLSLPPQPSVAPMPSTYLALIDAYICCGAPDLTWQMYLEMDAVGIPRTQSIVRKYVRGCYLSIKDKLDAANPEEWHLREVVDLALRDGIPFTSRMATSVLRMYGNNHVDGLVMLATLESRDLPNRKLYDELVQACVYANNIPGAIGVWEAFQSSEDAAITTATFERVMLLSCLHQPRLEAALSLLQEHQAARRLVAIPAYVSILREFYVKYTTNGEMNASGLNKSLKVLYERRTLFEEIEDQASILTSLTNSPDIAATTCGLAWSASLHKQLPCAPIMFAQHVHERFTIVRDKQAKTEAETATQAALRLTSDPLLFVLDAILSLPQLDVSLRVQAKFAKQLFALIDDDARVPAAHHVTHCFIHLDSMSMYLVQELEAIFNLVDADADRVAEFCARSCLADHHPEKTLNFVTARPAFFNPSTIELLVPALAEAYAQGVSITLRYVRQSLTYPDTQHVPLSFTRHLAELLDEFPNIDLRPLIREFNLQKEFAHVNLVAAIVPRTFSVPKVDPSIVYWSIPIPRDCIIFVDSPATIELAQRILLASEAVGWDVEWRPDFLSPTEKTKCSIIQLACATHVFICDVLHHMSDAMQSLLETLVLSPSPWKVTFGLKGDMEKMRYSFPDMSCFESVDEWENVVDVQQLMKKNKITPGLTKCCEQLLHLPVNKSQQMSDWEVRPLTEEQIIYAATDAYVLLELVKKLHPPQMRLKSAIAMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XHB8</accession>
    <name>A0A6G0XHB8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like modifier-activating enzyme 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_004829</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ubiquitin-activating E1 family. UBA5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000063">
        <property type="protein sequence ID" value="KAF0739657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XHB8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001212"/>
    <dbReference type="OrthoDB" id="206053at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071566">
        <property type="term" value="F:UFM1 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071569">
        <property type="term" value="P:protein ufmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00757">
        <property type="entry name" value="ThiF_MoeB_HesA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000531">
        <property type="entry name" value="NAD/FAD dependent dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF9">
        <property type="entry name" value="UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="9">
        <location>
            <begin position="37"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0739657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="365" mass="40451" checksum="0A9BA0A22BCC10B4" modified="2020-08-12" version="1">MSQAVATTARSAQNEGNAEENKRANVMSDKVEDSNPYSRLMALKRMGIVPNYQDIRSYAVVIVGLGGIGSVAAEMLTRCGIGKLILYDYDHVELANMNRLFFRPDQAGMTKTAAATQTLREINPDVEFEQYTLDVTTTANFEQLMERIRHGGVKPNASVDLVLSCVDNYAARMAINQACNELDQVWMESGVSEDAVSGHIQLLLPGRTACFECLPPLIVASGIDESTLKREGVCAASLPTTMGLVAAMLVQNALKFLLGFGQVSYFLGYSALTNFFPADVMRPNPECANKFCRQQQDKYKSTNWRPMEWKPNAPQNLESKHEDNEWGIEVVDEQKIEWEEPSSASTVQATQDQSLDELMAQLRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XHL3</accession>
    <name>A0A6G0XHL3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sulfatase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_004659</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000062">
        <property type="protein sequence ID" value="KAF0739768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XHL3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009684"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151:SF120">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151">
        <property type="entry name" value="ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026145062" description="Sulfatase N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0739768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="392" mass="42742" checksum="C458A92AC6ABE324" modified="2020-08-12" version="1">MLTNLILLGGVAAAANVANGFGSADHVILFGLDGLDVRCLQQALSNASIPNLQYFRTHGVYTDKARSHRPASSLPNWATIFYGAGIMFHGVTSNSWTYCSRESIDDQTFAPPYLDDCVVYPDIFSVAKQQKPDFVTAMLYSWGNLDAILPSETVLIDNRSYVEGSDCAGSQNASQQITDEAVALIANNSMPQLMFVYYNEVDACAHESSCFSDDGQAAITSMDGNIGRIFNAVRDAGFENSTVFFFVSDHGRNADGSDHTDKSSFNYATQWLVYGRGIIEGSRELKSAIATEDTSPTVAHVLGLNAPLEWHGRVVHEIFVQANASLYSAAKSAWSTCVNSQCARKVHHKEAKTEGSAINWTMGIISTCIVIGGLCLATFVRFYSHRRGYLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XI35</accession>
    <name>A0A6G0XI35_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_004515</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="VJMJ01000056">
        <property type="protein sequence ID" value="KAF0739932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XI35"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015026"/>
    <dbReference type="OrthoDB" id="6375174at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14531">
        <property type="entry name" value="PFA-DSP_Oca1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000035">
        <property type="entry name" value="Tyrosine phosphatase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020428">
        <property type="entry name" value="PFA-DSPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004861">
        <property type="entry name" value="Siw14-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF8">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE OCA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03162">
        <property type="entry name" value="Y_phosphatase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01911">
        <property type="entry name" value="PFDSPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0739932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="174" mass="20333" checksum="A6B4C4240EF45E3F" modified="2020-08-12" version="1">MSYFIPPVNYGMIEEDLYRSGIPNELNFPFLERLNLRKIVYLAPEEPNAQLLSFVEEQEIELVVLGGNTKLENRRKTWEPMSEETVLAALDIILDRSNYPLFLTCHLGRDRTGAVVGCLRKIQQWHLSSIFEEYRRFAGSKVRLQNEQFIELFDTDLVTIPSNPPNWIKSHMYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJU7</accession>
    <name>A0A6G0XJU7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">TNFR-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_004193</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000052">
        <property type="protein sequence ID" value="KAF0740459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJU7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010463"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF26">
        <property type="entry name" value="AXIAL BUDDING PATTERN PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026087064" description="TNFR-Cys domain-containing protein" evidence="7">
        <location>
            <begin position="21"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="457"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="75"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="258"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="485"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="259"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="331"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="386"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="397"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="487"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0740459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="510" mass="52650" checksum="424A94AEEE7F3C2E" modified="2020-08-12" version="1">MRSWTALVVTALLAVAPTQGVFRSQGGSDSVYLNDEAASSDLLASDASVLLDNEANKGKGGKYGRHHFLLEEEADKGQRRPASFLDEEANKGKRRKGDSPASSTKDVINPIGCLRCHPGSLLDEKVALSSVRLRGASLDDVARSNDLLQEVQEVEVLLNDNAANLFGRTLVDDEPPSPPSGRKCCTGFMPKAQCPGRCPTVSVTGQKSDCTKCHSHRFMPKKTCAQCSPELPCSKCRTHRFMPHAKCSKRDEYGNIVKPTAAPTPAPTEATTTAAPATEAPTTAAPTPEPTSYSSPSSNPTPEPTSYSTPSSNPTPSPTVYSTPEPTSYSAPPPPPSSPAPSPEPHPEPAPSPSSVPTPAPSSPASNDNGGNTNNKANDNNNGGASNNGGNNGGAPNGSNNNGGNNNNGGASNNGGNNNGGVTNDINNKPSSNTNTASATTTPKPTSSSSNSSSSKLSGGAIAGICIGALACAGAVGFFVWKKRKDQSREAEIFSDPPHDVEQGGDYAAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XK69</accession>
    <name>A0A6G0XK69_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Macro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_003959</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GDAP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000048">
        <property type="protein sequence ID" value="KAF0740582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XK69"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010250"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02905">
        <property type="entry name" value="Macro_GDAP2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035793">
        <property type="entry name" value="Macro_GDAP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106">
        <property type="entry name" value="GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106:SF72">
        <property type="entry name" value="GANGLIOSIDE-INDUCED DIFFERENTIATION-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="4">
        <location>
            <begin position="28"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="CRAL-TRIO" evidence="3">
        <location>
            <begin position="322"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0740582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="472" mass="52774" checksum="28F8DDF422818B17" modified="2020-08-12" version="1">MDIASIPRWNSLSPWENSSPGASPEGSNAPFQLNPGLNAKIALWKGAHWTLQVDAIVNPTSESLLDDSGVSGEVLEAAGDEIYVEIQAAGSCRTGDAVATRACQLPATKIIHTVTPKYNIKYKIAAENALHGCYRNVLRVAKEEGLTTVAIPCLYSKKKGYPREDALHVALRTVRRFLEHHGDAFDVILLCVDDQLDWHLYSKWLPMYFPRSKDEIALAASTFSGLPNLNLGDEYGEPVIEERKIRISSLVADEQARANAALERFTSDSLVTKDFCEMKDSPDEERLERIRKRNLGRAKSKSIEPKAAIPYQSYLDQAKHQDLQDIAKLKLIYRAGVDHAGAPVLMVVGKNLPVDAVDLERVMLFIIRVMDAVVERKYTVIYAHGEVTEANQPTTAWLQQLCKTFSSKYRENLKAFYILEATLWLKMTLWVGQSFVHSSFYAKVAYLDSREDVAQVVPTMVWPEDMATTKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XKD7</accession>
    <name>A0A6G0XKD7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_003750</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000042">
        <property type="protein sequence ID" value="KAF0740860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XKD7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000253"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF13">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF19 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 6 7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="79"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="171"/>
            <end position="178"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0740860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="343" mass="37731" checksum="F81252F063B42060" modified="2020-08-12" version="1">MQSGPANFRDAFALDPSAAGSPKNQRLAHLPSPQLSSLESPPAPRKDKHEAAFPESHDIDDDNNETEEFKRAMWAGQANILVAVRLRPQLKHDRDRGEIVKVLGSNVVVVLDPGNQKDVVGKMRNRSREKRYAFDHVFGPSDGQVTVYTHTTKFLIHGILQGFNATVFAYGCTGAGKTYTMLGTPDEPGIMALTLEDLFEHIQAAQAKVPSLVTYRVSVSFLEVYNENIRDLLRTDPDQDTYLDLREDPVKGPIVADLSEIVASNADEVMRLLRRGNKNRSQEATAANSVSSRSHAVLQVSVEQTEATPDTVTVFKTGKLSMIDLAGSERAAVTQNRHAILCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XLD0</accession>
    <name>A0A6G0XLD0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_003727</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC35F solute transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000041">
        <property type="protein sequence ID" value="KAF0741164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XLD0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004232"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009262">
        <property type="entry name" value="SLC35_F1/F2/F6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052221">
        <property type="entry name" value="SLC35F_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14233">
        <property type="entry name" value="DUF914-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14233:SF4">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06027">
        <property type="entry name" value="SLC35F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0741164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="37414" checksum="007CA33D98CFBFEE" modified="2020-08-12" version="1">MDLGQILCGHPMTESATYRRVLCLGQAISLCITLTSVCTQELTLNYGVQLAATQSVGNYFLLMSYLAHRWWIRESSDVSETPWWKYMLVAFADVEANFLVVLAYKYTTISSAMLLDCFTLPVVMYLSITFLHAKYAAQHYVGVSLCLIGIAFLITSDILSHRGKFTTDSFNATALFGDLLSLLGATIYGVSNVSQEYFVKTKSRSEFLGNLGLYGFIICSCQAYWYERHDFLAVTWTSGSVVFLSLYVLALFLMYSITAIMLRDGDSAIFNMSLLTSDFFGVLAGVYLFHQSLSWLYCIGFVTSIQKQTKSTSEPQEILRACTLRAIHLETMAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XM83</accession>
    <name>A0A6G0XM83_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_003449</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000037">
        <property type="protein sequence ID" value="KAF0741338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XM83"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016726"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="447"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0741338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="881" mass="101635" checksum="69E4CAF48BBD9EBD" modified="2020-08-12" version="1">MLHFFLDEWLEQFHREEQNYRSITVQAEVGFSEIEKLTCHVISKKLLWFSFWYSGSPQTTLRSTFAEWKRWHGFHMNQRMMQSLLEDCQKVASAQKNVAMLTETNDTLQEEFASLLDDNTSLYDNVQLLSYQIENAKRFVQSTLEREELVCFDGQLRMEVVSEVGYFILESLLRSQYNLGFHQRIIGPFSEDSSCLEQFFSYVLKIPATNPLSVPELTWESFITFLIELENFLRQNNIKFNIDDTLATKSSSQYDILLFHEWSTTCVFQQEHYIASPTLFFARHFEDHEISVYPTRDSASSPRTLGLQQNTTRHPSLSSVQSLLNLEKLQSSDLDLFSTHWQVLLVGRCFQEYGSLIFHQSDMSPYFHNWCISELLQKQKKIAKVTKPKASKKRITESGKEDRVKEQLIDHLPMRASRCIVNAYNLWTSICSDLCVATVVEVNSTSPAVHMTRSPSKQTLTSNRSASAVGRQDQPNLRMEKAPHFELSSTSIYLSGGPQASKKYGTFETSKLRSCDVYRVVELKRNIDELHDIVLRNWEKNKEVDATKAAMTHARLAMWNTACVLAQEKERMNTPLSSHTVSKDVRPSLFQVITWESKGICDIIQKEVDPESEMENVRRSFQVNDLYFRMLYAKAETGLDISHALTVEELWHTMKKLRVCTKVIPASLHDESVDHQVISVEEFAEIVLKICNEQFGEMTRLGQRVDRFVVEYLSSLQKPKSALHEEAQTTAMKSVLSEFKNTLHTIFKRFASKPRSKEKSVMHMKLRDWLGFIKEYKLVTTQFTSGLAQELFRSVQYEDSQEDELEMVFAEFCDAIIALAGFICHHLLITHTPAPVYRPLILNSANYLLGFALRCQAVCRPLCCVGLCCLELLFAMCASHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XMU6</accession>
    <name>A0A6G0XMU6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_002987</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000034">
        <property type="protein sequence ID" value="KAF0741794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XMU6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008509"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0741794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="133" mass="15084" checksum="5FD6CF76320AF9EF" modified="2020-08-12" version="1">MVLKTTLPPLAPTVQTLKRSYADTIRHSIDDITSLLLTTQLKEEQGVLAEKVHVSDRDSVQKKLVAVLIAARPNTPVHMRMQLPLLAKKLDSILLRLAKTKAEYMDPSTLLGRLQEVRTMRQAKKQCTEHFMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XN85</accession>
    <name>A0A6G0XN85_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_003048</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000034">
        <property type="protein sequence ID" value="KAF0741857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XN85"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000948"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45270:SF4">
        <property type="entry name" value="CHAPERONE DNAJ-DOMAIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45270">
        <property type="entry name" value="OS03G0832900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="12"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0741857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="252" mass="28716" checksum="05ADC66F6B1C4C8A" modified="2020-08-12" version="1">MSEVDRILAAPNHFFVLGFDTIEYVELAAVRKQYKALARLVHPDKCSEQGAEDAFKKLSVAYECLADEGLQCNYLAKVTGSKKRPRPTESSKKSKHQKHHQSPPSRPTRPRTADEIYADFLREEERQAEAEFLKRGFERNYDTNSYDKRPPSPPPVHSEDFIDEVLASGLENKQAKWSQFAQPQRHNQAQPSQPPQPSHPTAPRTESACCLVCRRKFLSHAHLERHEKDSKLHAENLAKAADRPSTDLDHKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XNP5</accession>
    <name>A0A6G0XNP5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase SPINDLY</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_003070</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000034">
        <property type="protein sequence ID" value="KAF0741879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012591"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050498">
        <property type="entry name" value="Ycf3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44858">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44858:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE SPINDLY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="113"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="199"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="1161"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="1294"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="1483"/>
            <end position="1516"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="1517"/>
            <end position="1550"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="1621"/>
            <end position="1654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0741879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2106" mass="236433" checksum="52AC7199CF48964E" modified="2020-08-12" version="1">MNERTIDRTSERYRLFVTCNWFCVLNRRGLNAMASVDEEEKLPLVDENEQVDDEEIAASSPDLWSKYDAMKGKATDLTALEMDSMAQWKWLNGRLGEAIDGYLDLARLHPKYLHVHFKLGYLYLILQNYDSAVQHFTLEIDKQAHNPPPKNVRRAKVFAHKAYFWCAVAGRMEAHQFLQKFEKRATDEALLMSDGGGTANAWIAMGCLYRQLGLLQRAEASFELASQIKPNDPTYLVEYGKLLLLQRRVEGALAKFSDCCRIAPALSEELFQAMLGEAIASMRLHKPTGFSESWTWTLNILEAAQGILQKVIDSLSPMVEQGLTPLLLNSEMDRSTIRQLLFQAINSQGCCAILQGDIKTALDIYYTVAHDYTDFQLPVLCVTPGARDAKGHLVDTAMLSTDRIVDLLLYLDQIESRYGPDACLYFHRANIYRALGDLKHFIDDLTLVETLDPLFLRGYFAHVRCRFCCQTHFEEQDSLGDFLDEETMTWIPLGVLETICEFTKPSIVGGPPPTISLIEAAVYQYFSARFASNPGDFYAQVFMIDSLRRLNMKDELPLAMHRLREGSGISFDDSLCHLDRNHATGPPLARRLAETLLAERPNHSSVQFVAGLVFMSELRLENAHHHFTQCIHEITKTMTQMETQAQVQGVQASNSPDATSRWTYQSFTRAKYHALVWRAVVGQLSLHNQEAVQDMRAAVTLLPQEPHAMFQKGVMMVHYGHLDSAIQPLRAGFQQLKQSGQSKDVNIALDYIRLAGMNVFSLLPLELKHNTVLAATDDALDDLPRRQNVGIDGHGGTVMYSNALDKMYEAGVLKLSKGHIAGAIKYFASITSIKPTYVSRAIDAMMDLHRCKDPRLIDDKVYVCHQELSQRAARFLQVYNLPLEGFKDLSACVAYYPHDVDMYWHRAWLHERLHNHDAAIDDFTQCIMLTRHGGKPRGVVLRRYMKMLLARAKVYMHEKHWELAMDDLNLLTEVTLQSKSVVETAKLIQLYELRSQVLVALQQYDAAIVEMETVLKLSTESIEWSDKTLLNMLLLANMHCHMAIEGQKHRQTGIFTTFLLPTRETPLSAASLASLRKANEYYAQVLDKAPTFPLALFLKGRMHALMGDSTLALDHWTKCLRQDPKFLVANFLKGSLRAQQCLPDLALAEFLTVRNQIPAYPHVQTSIGYCYYLQGNVKRAVVELTEALAHDPNDVEALYMRGVCLQELFALPTAISDFNSVLSRMPSHARAWYQRGMCHLLLKDYTSALIDLTKAAPHLRSGFAAVGYIHFCKRHYADAVAVYSHYLDERANDAPILLYRGFSYYRLGERTLAARDFDRALKVDSSCWFVHFIRAYIHQEEGDGTSAVVSIQKCLEHFKSVKSFHDATLHADRDRANPFFGYRLDVTLQQLKALVLFSSPASRRGSFGALDAARDTAKRAQLRAIFVKAVRRILFQARVVYALEKFAFKATAASVSLSKQIEQLTTPTAIQAPQGTFTPDSVAWAYNLVGVLATKQAKWEDALRHFTLAIRAAPSRPIPHLNRGNVYMEMRNVDKALVEFKEALQVDPNHAATMVNTALALYHVAQLEEACRYLYSAAPLVESIPAANAIVCFALANVTRELNRSEEAIEWYTKATTIPDAHVYHNRGATLHLHQRYQAALQDYSTALSLAPQSFETRLNRACLYLASSKCHHALEDLKCAASLQPDSATALRLLRFCERWHAALRVACSDFLYALDVFPCFQGLEIKAAAALWDPHAFHMQNLSLPDHPSRLALDTMLTTTKSEDLAFLLNEALMCTQDGQLHDAQRALLSAKYLSNISLHEELVCSVWSAQIAIELGDTPTAISTLRQAVRERKKTASAVSPRRGMSPSASILSLRGETRQARAAPPPSSSEVKANVLSDIYGSIGCLLRADGQLQDAARAFQSSLEHNRGNMYSLFNAASIHLEQQDFSSLLEALSSILTTTVSKLEALNTRQSRKSLLSSEAKAVDLLDAERDMVSVLPHMDLLATPEILQICRSIQAVFAQYKTCLTHQVAKHIPQLCVLQGQLATHVEALRDAVQGTSQDGGGESKRRLDLNDFNAAISRVTQEMVQGGTTSLNSTAMSDYLAEYDRICHAIESSFQSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XNR8</accession>
    <name>A0A6G0XNR8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_003061</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin Nup133 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000034">
        <property type="protein sequence ID" value="KAF0741870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XNR8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000961"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000972">
        <property type="term" value="P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037624">
        <property type="entry name" value="Nup133-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405:SF11">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0741870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1039" mass="115958" checksum="7C30D6FC297807CC" modified="2020-08-12" version="1">MFGRRQAAPSARPTPAYGTTTSTRKNSMLSGASQVVEKKRTVSVQSLPLSPRKPALHRSASIDLTVLSEDSTHAHHILQTLEETDFLDSNGQAGDTHVTFQRVYLPGHELGFFAILSATQLVLWNSHPLHRSLDGKESPALHLQSIYKLSYPPEMTPLDIRGSHLVLAATSFHNTAKICAIVLSRDGRVCFWEDISGASVPVVTRLSLDDSEHVVHASTSLPLIVALSSQKLWEVKLDDDRSSLRVSKIRSRRQGLWSHVARFLSSATPSPILLTKPLGTAELLVLHVDSTLERLAIGPEGMEPLWTFQLCAFMMDFFTQHEEGILVYSQCLNMPLATLTHFSLLVGFQTGTHVVLYLFEFMATLSEMPQYHRSIRLGDEPSLDNIQCLPVNDQSLYVVTPTHLFAVSVPAFPTMALHSHTITLPYQLASGVGVLNQSLIYLHPQPWSVRQFRSFQWTLTPSETLIPDAKRYKPTLDLHQHRSSAEWKSLLMDQFQQFTTSPITFHIDDAASHGLSQAVVELAQEILDAKPSTGLHWGGDGSTTWAPQLIKYQLQDKATRHRHWLHFLTSTGLFAALAVKAQHQLQEFEEKLVAAAALLHAEVSSDMLLQAMRSVLIDERGYTTDMMEATGYSVLDLFYGDVSQVDQLAFHLTDQDGAGPLLVIMLQAVALWRRGQDTFESSPDEPWTAQIGIRTSCRRILQAGYHDSALLELVQPMVRFMDDEEREVWTRCVLVPLVASAPAEELPSAVLDLIYAFEFLEGIAVLSPIDRLHAYMESHPDSANFFFEWYAGIAPNPWLPSTKVDLESLLHPPASLLPALHSFLKSHASLSKYAWMVSVELNQFSQASHCALQDARHETDSLELQKTLFSIGKLAALADSKPTEEFDRELLRVQVQEALELPHPLPSANVLHECMEQMSKSTSDRERALHWFRLGMDVVATEPKETLLLDLWRHAVVADSDLWLHILDEYTACTNESQLESDMKKSFVYLGMKDSPHPSAALTTDVVDTLVHESGTTSAVINLKTRPLLVKTLALVGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XPC3</accession>
    <name>A0A6G0XPC3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase family domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_002641</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNase I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000028">
        <property type="protein sequence ID" value="KAF0742367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XPC3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018982"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004536">
        <property type="term" value="F:DNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10283">
        <property type="entry name" value="MnuA_DNase1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.320">
        <property type="entry name" value="Photosystem II 12 kDa extrinsic protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016202">
        <property type="entry name" value="DNase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051675">
        <property type="entry name" value="Endo/Exo/Phosphatase_dom_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21180">
        <property type="entry name" value="ENDONUCLEASE/EXONUCLEASE/PHOSPHATASE FAMILY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21180:SF32">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE FAMILY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12836">
        <property type="entry name" value="HHH_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00476">
        <property type="entry name" value="DNaseIc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81585">
        <property type="entry name" value="PsbU/PolX domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helix-hairpin-helix DNA-binding motif class 1" evidence="4">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="Helix-hairpin-helix DNA-binding motif class 1" evidence="4">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Helix-hairpin-helix DNA-binding motif class 1" evidence="4">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Helix-hairpin-helix DNA-binding motif class 1" evidence="4">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="66"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0742367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="482" mass="54557" checksum="9C89C5F0420147FF" modified="2020-08-12" version="1">MTLLMQVNEASQEMLEGISGIGPSTSQNIVDRRPFKSLDELMDVPGIGKKRMAIIEAYFGSIRGSSGMKHRENKVDEPSSKYRPNYPHHYGSKPPQRFKTEMKVLDSTHDDPTQETRMQHKTEKTMDNAMARNKEKNEQTIAHVKIDINLATALSLQTIRGIGPKLSQRIVERRPFACVEELTSVRGMGPAILASIQNCVAVVRNPIKSSKKVTVLAAQNCIPRSPKVSSNLVLGTWNVHHLSKTRPLASLELMIRVLKPFDIIALQEVHDVIVVKRLAKLLRTFDYVVSDPVGRPGHWERYCYFYRKTLGLSAKRVHLPRESMTAVAMLARPPFIVSFEGSRRSLVLVNVHVVFGQRQHRVDEISVLKDLLRRLRDDAPSEIERLVILLGDFNLPPYDVGHIQGWDPILRPPHSTTIFNNLYDNIWLQPEATVVDSGVVRIDHIYFPATASRPYKSKEAAFARHECSHKLSDHCPVFVALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XPM0</accession>
    <name>A0A6G0XPM0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UDENN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_002686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000029">
        <property type="protein sequence ID" value="KAF0742283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XPM0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009409"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052809">
        <property type="entry name" value="Actin_polarity_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012860">
        <property type="entry name" value="Afi1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28245">
        <property type="entry name" value="ARF3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28245:SF1">
        <property type="entry name" value="ARF3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07792">
        <property type="entry name" value="Afi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08616">
        <property type="entry name" value="SPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="1">
        <location>
            <begin position="4"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0742283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="528" mass="59004" checksum="55812586C7456346" modified="2020-08-12" version="1">MIVDLVLYAEFDIDKGSTLRASFPAQPNELEAAVHRTPEFFADMMLPEGVHNREQDYTVFFIHEDNHVKYCLSVVKTMHDANVRRGARIKAVSICSNYHFCFAFKDVLSIAIDKLFALGSNETPSTATNVLLTLFNVINAVNVSGVTSLQASEVEVRLLKRSMCARPLGGQAHTSDESLVVNTQAQCDDHIIPLQIKLGNTHDQHEEGSLIDLIAKFGDQTMQIYNAVLAGSRIIMLGYGLPAGKVCNYVLSTSALLCPPLVGIVHRQFPYANLTDLAFISVPGFIAGVTNPMFKGRKEWWDMHCDLASGELLVSQPPEKDDADAADRDFILEVMDGIEAGFSESWVRCMFEEYTRQNIVDIAMGEAHFIDRDAQGRRTAINNKRITRWARTENYERFLKARETASATSSAFDVKARGVDLKRHLGVLMHENVEDETQVERIYADLVTLINDEDELKEMLSYIPRSKGGLHVIAQGLFHHSISVKYNTMVLLKRLESFTSTKDAVESLNPFIAATYSRLHATVVQPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XQP5</accession>
    <name>A0A6G0XQP5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_002429</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000025">
        <property type="protein sequence ID" value="KAF0742729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XQP5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002273"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0742729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="125" mass="14185" checksum="CA1FB06EF016B8FD" modified="2020-08-12" version="1">MKKSLERSCIKFVPLSRPVTFHVAIYTTEDEVPTAIWLQRQRSKVEWGCFVRDVANHTPKGAQYVLPSSVVVVSLVKALKKESNECRVDLRTRRNGDLTLVLTMTAFEGFKASYAFHLARLDTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XRB9</accession>
    <name>A0A6G0XRB9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Imidazole glycerol phosphate synthase hisHF</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="12">Glutaminase</fullName>
                <ecNumber evidence="12">3.5.1.2</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="12">Cyclase</fullName>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ae201684_002161</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 12">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the HisA/HisF family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">In the C-terminal section; belongs to the HisA/HisF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="12"/>
    <dbReference type="EMBL" id="VJMJ01000022">
        <property type="protein sequence ID" value="KAF0743104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XRB9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009972"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01748">
        <property type="entry name" value="GATase1_IGP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04731">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000094">
        <property type="entry name" value="Imidazole glycerol phosphate synthase hisHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00278">
        <property type="entry name" value="HisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004651">
        <property type="entry name" value="HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050064">
        <property type="entry name" value="IGPS_HisA/HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014640">
        <property type="entry name" value="IGPS_HisHF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010139">
        <property type="entry name" value="Imidazole-glycPsynth_HisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00735">
        <property type="entry name" value="hisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01855">
        <property type="entry name" value="IMP_synth_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21235:SF2">
        <property type="entry name" value="IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE HISHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21235">
        <property type="entry name" value="IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE SUBUNIT HISF/H IGP SYNTHASE SUBUNIT HISF/H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036936">
        <property type="entry name" value="IGPS_HisHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 12" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 12 15" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="3 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="16">
        <location>
            <begin position="8"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="354"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="392"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="462"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="488"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="511"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="13">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="13">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="13">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="394"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="14">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR036936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR036936-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR036936-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF0743104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="538" mass="58589" checksum="A26C0C42BCE8A0AE" modified="2020-08-12" version="1">MTDRVVHVLDYGAGNVRSLKNALHAIGYSSVDVQSVEDINNATVLLFPGVGNFQQAMSFLNKNNYVEALRAYIRANKHFMGICLGMQTLFEGSEECPGVPGLGVIPGVVSKFPSERMAVPHIGWNGINAHQPSSLFSHFDTANDPTVYFVHSFHASATPANQSWVLTRTNYGDIEFVSSVQHGNVVATQFHPEKSGAVGLAMLRGFLEGTPTSITNPQAPVKPTQLRKRVIACLDVRSNDAGDLVVTKGDQYDVREPSEGGQVRNMGKPVDLCTRYYNEGADEVTFLNITSFREQPIEDIPMLAVLEASSKQVFVPLTVGGGIRSYTDDSKRVWSALDVAARYFRAGADKVSIGSDAVDAAEAFYERNGQLDGSSSIEQISTVYGRQAVVISVDPRRVYEESAKHRTIELKHKPGPNGERHCWYQVMVKGGREGRDMDVVRLVQACEALGAGEILLNCVDMDGQNNGYDLDLIQLVKSSVTIPVIASSGAGRPEHFTTVFDVTKCDAALAAGIFHREEVSIGQVKAQLHQDGVAVRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XRF1</accession>
    <name>A0A6G0XRF1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_002189</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000022">
        <property type="protein sequence ID" value="KAF0743134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XRF1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015832"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43102:SF2">
        <property type="entry name" value="GAF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43102">
        <property type="entry name" value="SLR1143 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="2">
        <location>
            <begin position="42"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0743134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="379" mass="42276" checksum="F722502F90594EA7" modified="2020-08-12" version="1">MNTYGYELDFSWDHPWPRAPIPKNEEERLAELERYQILDTAPEERFNKLCRIACKEMKCPISAVSFIDKSKQWFKANSGLTQAAIPRDVALCAHTIMNPRNAVVVLDTTQDERFKNNPLVTRASSVKFYAAVPLVTPRGACIGSVFVFDVKTHTSCDTKLLQKIAAKVMKYLDERLKPASDVGPSTVPLPTQQTPLAPLTRSLSAEYRQPVPEPQPRGPPASVPPQQKQPTLERRMSGGSNVSNGYTQQPPAAPLKPQPRAQYQEPPRVQTPPQQQAIPQQQQQQLQRPESASALVPAASPEPERSLSTNTVNPEGQMTNMGAMLMNLLARTTETQQQLAAQQGVMFETLGHHSEQLNSLSETLSHLEMRIDRTIETKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XRU1</accession>
    <name>A0A6G0XRU1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_002101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000022">
        <property type="protein sequence ID" value="KAF0743042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XRU1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000580"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0743042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="366" mass="38805" checksum="C939FACB90A9C178" modified="2020-08-12" version="1">MAPIWAYIVLALAITTMSSGGMWFALFPETPPLMQSCWRLSLTSAMQGLGVAYELQSKSASLDELFWIRYRQSIPLLMVIGAAMGVCFGAWGWSVAHTTLLDSLLLVSTTPLLLVIVLTLRWLYRRSFTSDQREIVALSKETDAILGSSPSPSLFEAVVCPAEAHPPSWKEVVGTIVGFSGVIVLLVATTDENATSTQVTFAGNVSALIAALMNIVYLEGGSSCRKWMPLFIYSLSVTVIGAVSLGTASLLFEADTTVFGLGSTSLFGYFGDSRRFGFTFGSAFVAGFFGHACMNIAVVHVSTLLVAVSCLWEPLIGSYMGYLAGVQGMPDSTTLIAAPLLLGGALLVTLGGHQANVNAIALEGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XRV8</accession>
    <name>A0A6G0XRV8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_002162</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000022">
        <property type="protein sequence ID" value="KAF0743105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XRV8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009971"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0743105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="156" mass="16865" checksum="716EEA58BFEFDB08" modified="2020-08-12" version="1">MPPVQSTLGKAPVSKVAVSQTPRFKSDTAFPENYASSKQQRIFHPPDIVYEKPNIRNTIQDTVAQSHVKYGAMTSNAQRLVSTAAMVHNVVGAPKLRGTTTAALGPGTYSDERFARAPPPKKTSLSFAAILPSEVRTFWSLSLNGLIRSTQKIGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XSW6</accession>
    <name>A0A6G0XSW6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_001903</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000017">
        <property type="protein sequence ID" value="KAF0743432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XSW6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021684"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025533">
        <property type="entry name" value="DUF4419"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31252">
        <property type="entry name" value="DUF4419 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31252:SF11">
        <property type="entry name" value="DUF4419 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14388">
        <property type="entry name" value="DUF4419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0743432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="353" mass="39268" checksum="B1FFA77A23639D1D" modified="2020-08-12" version="1">MTTFAVSPVQVETFSGNQCSQIDEILTPLKEFGKEGCKEILQGTPFKGSLTPTTSGFVLGAVQAYNQHHDLVIRPDDIWLAIMIQFGFFVNGNAETLRESLVKHQGQKELEVTEIGTLYSVDYGKMAAQMIGKMEEHLVDPTLAQWVLPSFSTTTDHDRIVGSVVMMASMKKYFTYKFSLRCGIPNVTLLGTVQDWENIRSRVDGLKLYGGHMSEWVEMLDGVLDQFVASAKGNVNVDFWQRICHHIGGGSGPRYISGWLSVFCVFNEDGAWQGSTKSVTTWGEETVSDFPIINTNDIPSGYLTVDVTIDDNGVEYKALMFAGHLSYQVEEERRIAPHLSWAIVLKNGEPTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XTM9</accession>
    <name>A0A6G0XTM9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Gamma-glutamylcyclotransferase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_001446</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the gamma-glutamylcyclotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XTM9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002685"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061929">
        <property type="term" value="F:gamma-glutamylaminecyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009288">
        <property type="entry name" value="AIG2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039126">
        <property type="entry name" value="GGACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12510:SF4">
        <property type="entry name" value="GAMMA-GLUTAMYLAMINECYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12510">
        <property type="entry name" value="TROPONIN C-AKIN-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06094">
        <property type="entry name" value="GGACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-glutamylcyclotransferase AIG2-like" evidence="4">
        <location>
            <begin position="6"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR639126-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0743796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="180" mass="19820" checksum="22E2E9145330BE4A" modified="2020-08-12" version="1">MATTQVFVYGTLKRGFPNYALYLGPAEEKKKAIFVGEATTSTAYPLVVGGDRYVPFLLNIPGEGVPIAGEVFAVDQSTLEALDILEGTSTGYYKRELIPVQCNGLTIECFVYIRLVQDNDPLLSLERQSSYTKEASQGYRSRSVLPNMDILALIHDLDATKRHDVQTKLEAGVSLRDALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XU11</accession>
    <name>A0A6G0XU11_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_001271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000010">
        <property type="protein sequence ID" value="KAF0744129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XU11"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001446"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010530">
        <property type="entry name" value="B12D"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06522">
        <property type="entry name" value="B12D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0744129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="88" mass="9496" checksum="B616AA58CDB1731C" modified="2020-08-12" version="1">MVAQRLARSTARSWLSDPATYPIVGIVIAATSVASYAGFRYLTKCPDVAVAKGKRLNFLERHDANKGLAFRSHRNAGISSPKPDHGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XVG6</accession>
    <name>A0A6G0XVG6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Coiled-coil domain-containing protein 39</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_000927</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XVG6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006476"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060285">
        <property type="term" value="P:cilium-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036159">
        <property type="term" value="P:inner dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033290">
        <property type="entry name" value="CCDC39"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18962">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18962:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24161">
        <property type="entry name" value="CCDC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="914"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="216"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="412"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="503"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="712"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="920"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="949"/>
            <end position="963"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0744449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="976" mass="112404" checksum="32BA5BE8C02BCC1A" modified="2020-08-12" version="1">MDHDASGDGIVQSNDQPPAGAYSWKRSDGTVRGGQTNEVEDDAEDNASVVDVPLVTMVDDLPLFADDANKQLHAQIRSKEKRLHTVKQEISEAVNRFTIMEEHLKNVKQELINTQSLQNSKQKEISTEEHLRQVSDREAGRVRQEMKRLEIEYNDVENKLNAIQNFLFKGNEDMDTFKMQMNWNQDEMEQWAMAAKQKEDDNLALEKYTRADDSRIKELSLEIEKLTKTLQQQKQLVENEATETQAKQIELDKTAEEFRSMHEERQRLVKQWQDTIEAMKRRDAEIAAAGESFAAKKQSLDDKKDVLAEHKHRLKLQEQENNELQLKIAAKERLQSKLRADLQQANARLQEFRDQVELLKSQLTSAVTQLNQQRSYNANKGANLESMKEDLDINRNRYKTTKKILESCMNSTLDAETLAKNAETDLNAMEAESKRFDKEIALLKEQMFRRSQTLFNLRQNEASLIAEISGAQAANRNLLAKIKLLDQSALRQQELVYNGEFQIQQMERKVARASGERSADETKALKAEIEALQAEYDEALAQFSMLQTQCKKLSDEKAAQERTKKALLKTREEITAKIAKHELENESASNSLKAILREKEELLVQADLQKLEVKRLKDLLNSRADEVFTLENREFQLKKSMEERKKEISVHREVQRAQVKAAEEERHKISVEHADREMKVKKLQAKFETLCKTSPFGNSDEDGQERSQAYFVIKAAQRREELQREGDELDDKIRIAEKEVRALTKTLQHLEGRNTEYRKSFHRADMVGEEAAKMNQLEDQVKTAEDTLFKRKKELQRIQMEIESEQNRVQELEIQHRHFKEHNENLTAAQTQVLKELDMEKEKMAKVSKRMDKQLKDFRSKREVPVTTEEIVLDVHNSKEINNSLLYTLGQLAHEFPELSDVLHTNVKALNLHIPALPPGSTTTRSASTKTGASDSRPTSARSDRSDSSVKSATSSNGRNAQNRRVAPVSKIQMSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XVK4</accession>
    <name>A0A6G0XVK4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_000965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XVK4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021681"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF73">
        <property type="entry name" value="PROTEIN PDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="2">
        <location>
            <begin position="69"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0744489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="418" mass="47602" checksum="16C89158D7732772" modified="2020-08-12" version="1">MGKTRKLFMTTKVKAKIILHCQQNPSLTLREICEWAFTTQNLPSMPSTAAMSRALRKSIDEKTLKCRPNMKLLQPVTCADFETELVAWIDDCEEYGVQVTYGAIKEYAAKISAAYPKCAKLKFSQGWICKFLSRHNLRKRGVFGEAASIDENLVSSGRTDTQELTRSYSPQDVYNLDETAYFYCYEAKHTISKKQIKGRKVQKKRITIALAVNADGSDKRQLKIIGNARNPRWLVRRGALQNPLDYSGTAKGWMTSPVFYDWLRQFNEEMLYLQRRVILLVDNASPHRLNTTFSNVTLGFLPPNTTAYLQPLDAGIISAFKKKIRQRKTTAVLSKLEDLMSKHKPLGTRPSAKERAKIFVFETEVAVKWAEEAWAEVTQTTIKNCWKHADILGDDLDQPALNNESHNRDAASISFMLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XW27</accession>
    <name>A0A6G0XW27_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_001129</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XW27"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018512"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576:SF158">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 12-LIKE CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576">
        <property type="entry name" value="UNCHARACTERIZED NODULIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="331"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0744669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="42992" checksum="70B703AD72FBAE10" modified="2020-08-12" version="1">MLSIGSAYAISSWNAQLKDLLSLDQSQITTVNSSLSFGLYLAFIPGIFHDRYGIRATTIVATILLPLLYFLAYLQASSILSGSVWLLALTFGLLGLVSQFAGMACITSSEGNYGASHRGKVLGFVLSCFGAGGAVFAFIYHTFFDHHVASYFVFMAILSAVVCSFGVVFLLPNRHHHDSVTGEDQPLLSPTVDITGVALVSDKRFWLLFVPTMIGIGSGLLVNANLAFIVEARHGSATSVPILIALFSICNVSSRLIVGAASDASADIVHRGHYMSSGLLAMAGAYLSFLWGTPLSLFFSVPLAGMAEGCLFPTYTALTRELFGARHFGKNFGYMTLANAVGFPLLLGPLASYVYHSAATIDPVSGIEKCVGPSCFNPTFLAVAAVNAAGVGLSSQLYRSDALER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XWM9</accession>
    <name>A0A6G0XWM9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_000523</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000003">
        <property type="protein sequence ID" value="KAF0744935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XWM9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017622"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26312">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26312:SF87">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="420"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="105"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0744935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="545" mass="60969" checksum="7AA8CCFAC76852C7" modified="2020-08-12" version="1">MMASTMSTSSLREALQALGISSNTPGVRGDERRAILLARYMDATGGGGGGVKPGTSTAQQMSMTDLRRELELRGINTNTPGLRGDDRRAALLSRWQTHCQQPVVAAPDHEDHGESNNRMEEAQDSMADPMAQPSTSPLKRSQQLKAEAKRLQVDIDAIQQAKTHATTDDKERKRSKLSAELENEKIAALHDLQERIKKQSLVGFNEILQVSKEDERRTSPTKPTNKRMNPLLQTQTLTDLRRQMLPTTAAMTSRSDSLETVNQDRIHSFPITQPTALSRADSLGRKAFFLHRIKGDFAAAEAAYNEAIDADPTHSVNLGHFALFLDRVAKRYDDAEEFYLRAIDASSEIPMHLSLYANFLNRVRHDSVRAEEYYLRCLRDFPRDADTLGNYANFLRYTKHDLAAASSYFAKAMAVDPSHANNLSQFASLLSEMGQLDRADACYEKAIQLDGDNPTICGNYANLLVKQAKLDAAKSLYLKAMQLDPDSHIAQQNYAIFLRDHPSMRTGETRRIAMHPKDRWAMSVKQTTQLVRATAAFQKQNPPVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XWY0</accession>
    <name>A0A6G0XWY0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_000617</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000003">
        <property type="protein sequence ID" value="KAF0745040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XWY0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001740"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF67">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HUWE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="9">
        <location>
            <begin position="140"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="9">
        <location>
            <begin position="239"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="8">
        <location>
            <begin position="440"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0745040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="761" mass="87129" checksum="DF8A561F725778B9" modified="2020-08-12" version="1">MGARVSAKRIVAGRRNESNESEFDLDEDERRIKEIQEKNKQIVVSFFVARFFQCVRIKIQRIDMPEDVKEKKKHVYLWITIDDHVLKQQNVPLDATFSYPLAVAVDITGDTYVTDRTNGQRRLKSQDILALATATTPPIPPDSVSLIEATGHSLRVGWREASGSIVDRFEVQYKLYKDMHGSKPWLFLANSILPSHMSLEMLDCHTAYVFRVRSHNPAGWSDYSPLSGPFTTLAGAPEKPQPPFAAVISDTFINVCWTPVPDNGAPILAYSLEMKNAHQINSVFTEIYRGRDCGYLVANLAPKSILMFRLKAMNSVGETLWTESKPIRTKEFARPEVQELPSGGTDRWVECWDGKEEKVFYFNKYTCQRSYEVPAEILEARRKAGDSESVESPEMIFRKKRFHFHRELRANLPAHTAPFDLTLHRQTMFEETVARFQRASKKDLQLKPRITFDDEGGIDSGGLTKDWYLQVSRLAADKSRGLFRPLDNSLLEINPEADTPDHLKLFRFFGKFLAKAIFDRHVVHLPLAPVLYKHFVGLAITTEDLIAMDPQFHKSLKWIEDNDVTDVLYETFSITRSNNTIVDLKENGRNIDVTEANKHEYVKLMLQWRTEFAVRPQLDALFNGMHVLLPNHALHCFEWSEVELLLNGNPNIDVDLLRANVNFQGGYDANAQVVLWLWQALRTWDNAKRQLFLKFTTGSPAIPLDGFEPPFTITKSDLEPTALPRSHTCFNQLVLPEYLSYAVLQEKITFAIQNTEGFELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XWY2</accession>
    <name>A0A6G0XWY2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_000579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000003">
        <property type="protein sequence ID" value="KAF0744996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XWY2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014743"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0744996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="74" mass="8271" checksum="C454C21EB41C1A25" modified="2020-08-12" version="1">MSVLRSLIKYPNRVKDMQALFNKNPHLVGAENPTFLKGQNDQAVFFASIALASFGGLQVLRGFWNMSWGVGKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XX25</accession>
    <name>A0A6G0XX25_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CHCH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_000567</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the COX19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000003">
        <property type="protein sequence ID" value="KAF0744983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XX25"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001821"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010625">
        <property type="entry name" value="CHCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051383">
        <property type="entry name" value="COX19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21107">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21107:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06747">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHCH" evidence="6">
        <location>
            <begin position="27"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0744983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="115" mass="12717" checksum="E63F0792FEB830D7" modified="2020-08-12" version="1">MNAFGGAASQAKSPEKGSFPLDHYGECKEPMKVFLACLKEKKNSHIECKHLSQKYLECRMDKGLMQQENLDLLGFNQEAFEKAKAKAAPREGVTEKEGFVSGLRVKGGILKEPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XYW1</accession>
    <name>A0A6G0XYW1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_000227</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000001">
        <property type="protein sequence ID" value="KAF0745780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XYW1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000429"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF7">
        <property type="entry name" value="RE15974P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0745780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="251" mass="26288" checksum="D6AE7C30C6022B92" modified="2020-08-12" version="1">MSLIGKVALITGASRGIGKAIAQRLANDGASVIVNYASNSTHAESVVQDINSKATHGQRAIAIKADVSSYDECKSLVQQSLDAFGKVDIVVLNAGILNNVTLDQITEEAFNQSIGINVKGPLFLTQLLSPTFQPGSRVIFISSSLTATSSITPNYTLYVTTKGAIEQLSRVLARDLGKRGITVNTVSPGPTNTELFYEGKSEAVVNAITSVNPLGRVGEPEEIANVVAFVAGPDSSWVNGQNIRANGGSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W4E7</accession>
    <name>A0A6G0W4E7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_018874</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000362">
        <property type="protein sequence ID" value="KAF0721838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W4E7"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0721838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="91" mass="10575" checksum="06E8E4F576701336" modified="2020-08-12" version="1">MVEGCYDYGIQRASSSSTQSRPVDPWGLHFWQSQRRCPRLVAKLTKWDVDYPVLFMYILVPSRSLPFYLDVKCLALSKAARSFYFSSIQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W4Y4</accession>
    <name>A0A6G0W4Y4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_019116</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000398">
        <property type="protein sequence ID" value="KAF0721490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W4Y4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005507"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF467">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0721490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="21934" checksum="98906FF54B5AFE3D" modified="2020-08-12" version="1">MQGGSKRPLRYLKKTRLYGLELRPTKGLESLDEVFADADWAGDKTSRRSTTGSVVTIGGCPTQWMSKRQGVVALSTTEAEYIAASLGTQEAMWIRQLLIELGLKPVGEPTRLWCDNQSAIANMQNGATKSWSKHMDMRYHYVRDAVQDNKIKVDYCQTGRMPADIFTKALATETFERARHMVRVLAPEDSSIKMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W6R8</accession>
    <name>A0A6G0W6R8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">oligopeptidase A</fullName>
            <ecNumber evidence="8">3.4.24.70</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_018010</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Hydrolysis of oligopeptides, with broad specificity. Gly or Ala commonly occur as P1 or P1' residues, but more distant residues are also important, as is shown by the fact that Z-Gly-Pro-Gly-|-Gly-Pro-Ala is cleaved, but not Z-(Gly)(5).</text>
            <dbReference type="EC" id="3.4.24.70"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the peptidase M3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.70" evidence="8"/>
    <dbReference type="EMBL" id="VJMJ01000319">
        <property type="protein sequence ID" value="KAF0722933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W6R8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003736"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06456">
        <property type="entry name" value="M3A_DCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000009">
        <property type="entry name" value="Oligopeptidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034005">
        <property type="entry name" value="M3A_DCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43660">
        <property type="entry name" value="DIPEPTIDYL CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43660:SF1">
        <property type="entry name" value="DIPEPTIDYL CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="10">
        <location>
            <begin position="230"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0722933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="681" mass="77389" checksum="B3CC8D40DA62C19C" modified="2020-08-12" version="1">MSSTGNNPLLADWSVRPYSFPPFEDIKAEHFEPAFQVAWAKHLDELKQIADNPQEPTFENTIKTFDRVGGLLSAIQGVYFNLTASLCTPDLQVVQRKLAGPMAEHRAKVVSFPGLFERINHVYKMRTTSNLNAEQIRLVERFHLDFVRQGALFDKKTQDKYNAIVKELAELTTTFRQQVTTDESDVVVHVDESELVGLPDDIIAAARQAAIDRKLDGYVITLGRSLVEPFLTTCENRDARERVWKAWTSRGELSPDRDNCSIAVRILKLRSEQARIHGYKSFAAYQTNDTMAKTPEAVMGLLERVWAPAKVAANKECQVLSEYAVSVGNNPDIRPSDWRYYAEKVRAAKYDLDESEVKPYFSLDRMVEAVFNVANRLYGISFHLRTDLKAYHPDVKVYEVREGEKVVALFLHDNYARPYKNSGAWMSEFRSQSRNVDDLGTNVIPIVINNNNFTKGSPTLLSFDDCVTLFHEFGHGCHGMLSNSTYQRLASTNVLKDFVELPSQLMEHWVRQPQVLAEHARHYKTGEPIPAELLSKVMAALRFQQGFATIEYTACALVDQALHALENIDGLDLNDFEKKKLAELEMPDGIVMRHRIPHFAHLFASSSYAAGYYVYLWAEVLDADAFDAFLESGDIFDKATAARARKYIYSAGNTRDHMEGYRLFRGQEPKIEPMLKKKGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W718</accession>
    <name>A0A6G0W718_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosducin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_018117</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosducin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000320">
        <property type="protein sequence ID" value="KAF0722886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W718"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018994"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.168.10">
        <property type="entry name" value="Phosducin, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051499">
        <property type="entry name" value="Phosducin-like_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023196">
        <property type="entry name" value="Phosducin_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024253">
        <property type="entry name" value="Phosducin_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46052">
        <property type="entry name" value="PHOSDUCIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46052:SF1">
        <property type="entry name" value="PHOSDUCIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02114">
        <property type="entry name" value="Phosducin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosducin" evidence="3">
        <location>
            <begin position="63"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="14"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0722886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="272" mass="30861" checksum="1D9C3C5D9D16383D" modified="2020-08-12" version="1">MDDFFLRHDVYKDRDPDELNGKVNSDSEASDTEESLPASVHDPFSPWQEQFLDKQGKRRSFKKSTFTGPKGVLTDYKAYKKAKAQERAQEEAVRQAVLTRIACGYVDPSQSTTTETVPQEEAQDSDDEFLNELEDDTVLQSYCAKRIEEIKSTINAGAPSFGSIKYCSPFEFVDLIDSADPRTCILVHMSDEHNYVCTAVNQCLQQLCAEYPLLQVLVVQRGEVEATIRTDDVPIFMLYRSGQQLDTILDVYNKLKGEVTVERLVQLLAEYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W7A6</accession>
    <name>A0A6G0W7A6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_018065</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000319">
        <property type="protein sequence ID" value="KAF0722990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W7A6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010236"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="15"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0722990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="153" mass="17330" checksum="DA2D40FF080BB82E" modified="2020-08-12" version="1">MQSTEAVKSHIHPSCRVHVGQIPPWLLVEQKARDYFDKYGRVTAIDIHRDPWDTQACGFCYVTFASPEEATTAVASLQEELAKNESQLEAHVAFTRGAVDAKNLVSEETTDKLAYVSQRQPSQMTEEDEDDRLLFSLSQRSSQGMSMRHSFLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W7E3</accession>
    <name>A0A6G0W7E3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tubby C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_017924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000317">
        <property type="protein sequence ID" value="KAF0723053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W7E3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018635"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.200">
        <property type="entry name" value="LURP1-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007612">
        <property type="entry name" value="LOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038595">
        <property type="entry name" value="LOR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31087">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31087:SF85">
        <property type="entry name" value="PROTEIN LURP-ONE-RELATED 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04525">
        <property type="entry name" value="LOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="Tubby C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0723053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="201" mass="23006" checksum="503744D636A5215A" modified="2020-08-12" version="1">MARSMPSYDETMLKPLPSMISILDAKFTTWTPLQLKFKPHLVSWSIVDAATDELYFRSTGAWSTRRLLDQRDNVVAVSKVHFFTMEHRRDVYTTDKRDLCVMSCSVSSASSRLNCLVVVTITRQQYSFDVEGNWKQRQASIRCNDHIVAKTKRQSWLQNDLQVEIVPGMDAAFIALLCLMLERAARDDHRRRLAGMSGGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W8B6</accession>
    <name>A0A6G0W8B6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_017712</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000309">
        <property type="protein sequence ID" value="KAF0723371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W8B6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011617"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0723371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="238" mass="26621" checksum="418A4F77A5B7D510" modified="2020-08-12" version="1">MGSGASSLQVYRRRALIRQHHLDPNVVLATSLRAMWSSQTSIRTVAADLAQKFHLDVDMHELHVALETLGCVSLDAATDLMDVEPLVAFCMPRKARMIFPAVSIWLACKNGDVDGLKAWLAIDGDPTWRLPDAFGNLPIYYASLCGHSTCVQLLLSRYEREAAAQSGGFPVDIDALLPPLERQRCITNALHGDIRRLLELQTTEQRSRFRPELTDMAKEDDDDEDIVGTTNWDLFETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W8P2</accession>
    <name>A0A6G0W8P2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_017624</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000305">
        <property type="protein sequence ID" value="KAF0723469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W8P2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013100"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013101"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF2">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3-PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="532"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="567"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="SAC" evidence="2">
        <location>
            <begin position="134"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0723469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="723" mass="81435" checksum="80B06B17A7A66719" modified="2020-08-12" version="1">MSRLTKGSTGRFELHILSDLTHLAISQKGNAQCLLLNRNSASGTGIALEDVTELNHAHGRSLQFDAIFGIYTLLRGKYLALVTESRSVGKFTVRGSDVEVRQVTAIEMVLLPTQQLPHLTPSQLEDEERYIAMITTNVEAQLLYFAYDYDLTHTLQRISTTVSPTMSISERADRRFCWNYAASGFLLEKKLFAWVVPIMQGYIEISKGVTVGAKTFDLLYVSRRSCRRQGTRFTMRGIDEEGNVANFVETEQACLYPDGRETSFVQIRGSIPVVWSSPVTLKYAPKVYQRNQLEPNTAAFQLHANEMMKYYGRVIMVNLIDKKKEQLKLGEAFEKTFGHASALDTHILANIRYVWFDFHHECRRMQYGNLSKLISQVDDDFMDYGYFAKSATGQVTSTQSGVVRTNCMDNLDRTNVVQSLFGRRSLLLQLGESVEGNVLTSPFNSFEKTFKNVWGNNADAVSFLYAGTGALKTDFTRTGKRTTRGALQDGYNSVLRYILNNFYDGYRQDAMDLLLVRYTPSRHKPSPFVHSAILQTYMLALVAAILVVFASLSAWDGFDTAFLFNRLVHALAFVIGVISVSFGYFVRRGSGQLFAVRPSFRPQDGCTCVCRQLTKPLPSYIMLALRRAAARVQMPSFSAAMPTRSFSDKFAEKEKAEEARFFNKEDEKALRKLLAKLKEQADHVDSHGKQTQETAEKQALSKILGANASPATVDALLKWKHSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W927</accession>
    <name>A0A6G0W927_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prostaglandin E synthase 2</fullName>
            <ecNumber evidence="3">5.3.99.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Microsomal prostaglandin E synthase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">Ae201684_018271</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>prostaglandin H2 = (12S)-hydroxy-(5Z,8E,10E)-heptadecatrienoate + malonaldehyde</text>
            <dbReference type="Rhea" id="RHEA:48644"/>
            <dbReference type="ChEBI" id="CHEBI:57405"/>
            <dbReference type="ChEBI" id="CHEBI:90694"/>
            <dbReference type="ChEBI" id="CHEBI:566274"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:48645"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>prostaglandin H2 = prostaglandin E2</text>
            <dbReference type="Rhea" id="RHEA:12893"/>
            <dbReference type="ChEBI" id="CHEBI:57405"/>
            <dbReference type="ChEBI" id="CHEBI:606564"/>
            <dbReference type="EC" id="5.3.99.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:12894"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; prostaglandin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Endomembrane system</location>
            <topology evidence="18">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.99.3" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000327">
        <property type="protein sequence ID" value="KAF0722672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W927"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018196"/>
    <dbReference type="UniPathway" id="UPA00662"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050220">
        <property type="term" value="F:prostaglandin-E synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001516">
        <property type="term" value="P:prostaglandin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03197">
        <property type="entry name" value="GST_C_mPGES2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011767">
        <property type="entry name" value="GLR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034334">
        <property type="entry name" value="PGES2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034335">
        <property type="entry name" value="PGES2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12782">
        <property type="entry name" value="MICROSOMAL PROSTAGLANDIN E SYNTHASE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12782:SF5">
        <property type="entry name" value="PROSTAGLANDIN E SYNTHASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01182">
        <property type="entry name" value="Prostaglandin_E_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01203">
        <property type="entry name" value="Prostaglandin_E_synthase_like1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00195">
        <property type="entry name" value="GLUTAREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0643">Prostaglandin biosynthesis</keyword>
    <keyword evidence="5" id="KW-0644">Prostaglandin metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="GST N-terminal" evidence="19">
        <location>
            <begin position="41"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF0722672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="268" mass="29959" checksum="45B4CF6474E2BD20" modified="2020-08-12" version="1">MHRAFGRIKAAQLTSGVMGVSCMTSFSTSATTLSKAAPEVPQVTLYQYEPCPYCCKTKAVLDFLNVPYNVVEVNPVTKKELKAITDYNKVPVAVVDDEIVPNSSDIIARLQSTAGSPLGVAPVDKEWSEWIDMKLVILMPPNIYRSIPEALQAFEYCLTEGNFTAWERRVSLYTGAAAMYFISKRLKKKYGFDDARLALYDVTQYWLDAMGEKPFLGGDQPNLTDVSVFGVYRSIVGLDTFDDLMANTKLQPWFDRMTEIVGPSKRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W996</accession>
    <name>A0A6G0W996_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein mS23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_018223</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000326">
        <property type="protein sequence ID" value="KAF0722746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W996"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000654"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23701">
        <property type="entry name" value="At1g26750"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059242">
        <property type="entry name" value="mS23_dom"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0722746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="165" mass="19392" checksum="85D941EFB5999756" modified="2020-08-12" version="1">MGRARRVIKNVITHTQGLVRNKGIEDPGWLEAVNRYPPPPMPRREFDKLPRITFPQDRLAELYAAKSGFPTDDETAYEFADEQLTLIEMGVPEKEAYEMLTAKYEKVESERFLQKFYQLRGQEFIPSTKPEEMAKRWEEEEAAAIKDAMRMEFEDQQELNSGKWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WA69</accession>
    <name>A0A6G0WA69_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_017031</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000275">
        <property type="protein sequence ID" value="KAF0724251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WA69"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006016"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="6">
        <location>
            <begin position="421"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0724251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="496" mass="55628" checksum="1D4D75C0943460D7" modified="2020-08-12" version="1">MKMSKATKKLDMYDNSKTRSNSTCINGAISGPAHSSVKRMKQSRISDSMESARVVAAARKVSESFDHADQEDSLMHILSLCMLYALGMRENTSKGEVSTPGGPFPQGPILIDKLRSLAAFFEAPQRSHKLDKVKTEFRLPNIRAHVDAPTRIGFVSSLLSSSLLNEYAYKMYFETYPDDKVDVFRSISSDDWELAAELEGIMNALAAFNLGEVQTEKVSASFSFLLLHEATSVVRASAVNCFTRVRPEKSSNVANWPRRAVDVDSLSSHALCCLRRLNHQVDIRLPKPSMNQHKAMLLDPRVKSIVVPEYSSDRDEAIEQLLVEHRSVYARLALKQGPTTPPATTMAGELDAGDEAICDDVDEFAVPRPRENFNPPSTSLFLLELEADEVWRKWAAFEVSWERYTTADVVKTGSHGCMYDVWKLYKEIDVLAWYRDVGVTAFPSIAILARTYLAKPMSNAFQERFFSTAGHVVNTKRTRLDSSRAEKLQILMHANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WAP8</accession>
    <name>A0A6G0WAP8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_016980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000273">
        <property type="protein sequence ID" value="KAF0724317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WAP8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021486"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="390"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="441"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="249"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="406"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0724317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="512" mass="58651" checksum="A118FFE2B37DDC52" modified="2020-08-12" version="1">MTQLMECHQGAQAELAKVRAEGDWVLIKIEMEKKTLEATIAEINEVKAQIAAIHAAKLQENPIIPSTDLHKHVMNLQHHEERQKGHLCEDLAKISMLRHMVDEARRVRNEALAIETQEIKKAKHWEDMIRTVHGDIQELKARESSIAEEIYQLQLDMDEERVKFFADKKDLMDQLHACNKPNDHVHHDAIFKQRAMRNKESLLKRTETLEQKKDKLDMVLLKSNMPNVQAFIDQYTKQEETKAALCFEIERQSSQNAVLQATIRQLVAEKNKFHDIHTMDGLNPYCEDLRNQARKSRAHAEKLHSEAEILDNTYKKLQGPLHDLYALTHDIELELPPTTPKVVLEHLASTEEKVPRKVLSKIAHECASGNWQESISLTRLLDSRGVFRPKTLHAPTSLPTTTSGTDEGDDDDDDDPIMEPVEIVHSKDIIRELRDRHATLSQASLATSKSRRGLSRMQRPSTFREAKRRMAALGSERELRSESSFKALPLARSDLSDVELLGESKMLQPLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WBA4</accession>
    <name>A0A6G0WBA4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_017325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000293">
        <property type="protein sequence ID" value="KAF0723874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WBA4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017205"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0723874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="211" mass="23772" checksum="DFD4AC1BD161881A" modified="2020-08-12" version="1">MNVYRVECRGSHYRVNGDDVDNISVSFKEISGMPGVPSVFLDNFIAGHGRLPTDGLMTHNPPLFRFTADAFQVPTTILWCSGWLILDSKFVMCLDDLPNVILRVLTGISFGHVYCCCIMNEGDRRFLVPHLMTMPVFELTWRSLLHISLDALWVKKLQEGEKDIGNFSERSQSLKSTFSQRNTERKSIVNKTAKSKFTRVAAASILGPKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WCH3</accession>
    <name>A0A6G0WCH3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_017201</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000286">
        <property type="protein sequence ID" value="KAF0724035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WCH3"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0724035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="76" mass="8777" checksum="208A482211437947" modified="2020-08-12" version="1">MTVRPLQRPSEAASRRFHARFCTIRSPAKKMVVLSVVLSQVLPKKMTSDHPQHKTHLQLWSQREFPSTAQRKVVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WCI3</accession>
    <name>A0A6G0WCI3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fido domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_016529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000256">
        <property type="protein sequence ID" value="KAF0724909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WCI3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009855"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="entry name" value="Fido-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="Fic-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="1">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0724909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="126" mass="14636" checksum="8FC004E7A33C08D1" modified="2020-08-12" version="1">MAVGYASERIYRVFMPAVEIQKSLDEYVHTLNDPSAFPHPLVRAYYAFAALVFYIHPFYDGNGRCARLLGNILARKHGFPNGIRHLDKTIQLSSFLETSLHLMDLHEEAQRNRRNRLNPKNTSTWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WCR4</accession>
    <name>A0A6G0WCR4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_016465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000253">
        <property type="protein sequence ID" value="KAF0725067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WCR4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003469"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0725067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="417" mass="46871" checksum="8BA351584CEB42A0" modified="2020-08-12" version="1">MDSAFLHEDKSLFDFNDLVMGSMGDAAATVSLDHVLSEDSLDDSSSTSGKKRKYVNRQKLELEYLREKVEALQKQMEILGSMQTNQQQTGSEWKDLAAEQKMQTQMAFLENARLRAALQEELAFAETLAGIVRKKPKVLDLPTTKDLQWREFKLVDDPEDRAVAFSAIPDREYNKVINTLLQRDADTASKKTVKSTTVKYLDDGVVPGIVIESFNRLTFPGVHFHILGFALWSFINGDIGDVTAAPGMSSDTFEKLATLGDNIVYMKSRWRISESLFAESRLLIKRFVEEGRQIVVWRNIIDDSLIPLDPNALTFHGSGWAMVEHDVNSTVIQFFTEISTPLTQVAVVPAPLSPPSDDENDAVVDSQFQVGTFTDSILSAYRNAYRRFENASMRAWSKMQQDQTASLLTNLDAFLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WDL6</accession>
    <name>A0A6G0WDL6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_015914</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000237">
        <property type="protein sequence ID" value="KAF0725581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WDL6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021171"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="125"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0725581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="270" mass="30849" checksum="1EC746E61D96F1D6" modified="2020-08-12" version="1">MSSFDESSDVVDDLPNTSEVPEGWIKTVDEHGTIVYQHVMSGHCQAHMPVVDPSMKKKKSRRSISHRTTSKSIIEDVLPDKTDDTQVLRNESKSMVTDYLGEVEKFNAAKPYARQPDNSYLDTLCICCKQRRTHMVFFPCQHKCMCDLCIKGLKVGRPPDHDSPFRGCPVCQCEVTKMFEHTGHEEQDFWDWAYEVKPYLSAAFEHKFKMTGRMLGRRTSTGAVVPTNIEAKHTRSRQSLFHIPMPHRSGAVYMQPPQSPTNRHRSCGVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WDN1</accession>
    <name>A0A6G0WDN1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Exportin-1/Importin-beta-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_016844</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the exportin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000270">
        <property type="protein sequence ID" value="KAF0724436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WDN1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020467"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040016">
        <property type="entry name" value="XPO6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21452">
        <property type="entry name" value="EXPORTIN-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21452:SF4">
        <property type="entry name" value="EXPORTIN-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="409"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0724436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1064" mass="118162" checksum="E428F036AD9065B0" modified="2020-08-12" version="1">MADAGFDDALDIALGFSPQATANDRQLAVNFLAQFKTIPHALHTLQTTNNEKRLWFATSTLEELVRSHPEVDCTPLFALLWSAVIDPAGRYPNYIVAKLRLVLVYAVLRQNNLPNFIDTLCETANSSQTNSPFNLPALELLSALCEEMSNQSDSRGSFSALSSDHASHRAQFRLHLEKLVDLTLNILKAIGQWASQPGMNLDALASVTLRIAGYLCMFDGLSAPVLKDLVCILGEYATNRAYTEQQARFSLLLSSCTACDALMTIFSKKWPRDVTVVVVESGLAVVLNILSALSEVRIKNVGDDYLDKVSALVEAYLTSHLRHLHSPQFAASLSSLLGQVLELTIHQPHTSGLFHCLTVWEVFITHVEDAEESGAQDPQLLRSYEKGLVGVMQHLVQRMLYSSNQAQLEELDDEPPPRQNTANSADISGDDSQEITTGTLQDQGQETAELSDLKAFVFECFSLTRRITKLPGCAQPLLELVLPAVRGNCQQFMQIHTLPIPAERSSEVHAVHDLTVSCALLSSVAAQHYSNSYVLSDKATGWDILLLFIQLAEYTVAHRLHTRGAVYVDFECEILTCVRQSTSCVPFVYQSGGSDSLKSAGESITQIVLTTLDSSIVPSPQTVVQAALNLLACIGSVFPHPIQDEIPSMQQLKTNMQRFGLHLPKSVQGSLYIAVLNSIFSGDWNQTAPGFSAILSPVLNSLVESIVTMQQNSHRVVEASLFSQLMRDITVVRSISNAIVVKPKVIKVAFYSQIQPVLPYTLEVLRLYLSYLYQNNSTKPQSAATAINELIGLYGDLFRSIRKELPNEIVTQIVTTLVELFQNTQLALKLDELGESGTSILSGFLKLLRTLVEESTPTTASLLQSILELCFGSLNEVIFAPRHFDSVAPFFVSLMEEILENHYRFFVVTRNTFDENGQRLKEYPNELAGKYFAAILKAIVTILQQENLPPPVCKQIIVSLERIHSSHYLFRFAGFRSEILMAYVHTILNLLTSGRFTLLTEELSLLLYHMAQVDMTSFYQVCLPLYTGEKRSLSLRCWSGQSDEPTFLKDLGNFLNDIKVLQSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WDR6</accession>
    <name>A0A6G0WDR6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_016052</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000241">
        <property type="protein sequence ID" value="KAF0725489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WDR6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019266"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020504"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="544"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="611"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="851"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="292"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="446"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="516"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="544"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="851"/>
            <end position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0725489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="881" mass="100808" checksum="9B1FD194E652FC29" modified="2020-08-12" version="1">MPPKTKPSEPTPADVEVTPLRRSARLSGSEPTQQPVEDPKRILREHRAAQRAEASRFRPDPVDVEMDVHAERKRASESTPNVSPDYPSGFIRAPLKYLRTVSEDEISEGLMSGEETKEEISDEITFTALPESPRKDEDSSDVVHEVIDLTAESDEDEMVALRPNDNEKISELESASVDEPKNREHISDEEMREQVRAEVMVELIKQFEEAIDLARRTKHEDELRALDEIQRLTVEIVELKSFVTNISSENAHLNDLLTKKDDDIKRLEAGNRTVRGEAEMLRFASQKPCSRCSSLEEKLNQSIDDYENLRSTLNTLQSEQSDTQVREECLKKSAEIELLRRNVVDLMQQANASLKQAETNHQGDIDQLEGEIEFYRNQYKKLVEKSDEKENKLLVELFELRRLSATECSSCPTLRDEIQMLGQKVTKLGLEKSQEAQSSEMAKQRVLTLEMQARTQTVEMEKLQDEMTLLQSQLASSKTSLESYEEKVKIFGEYEAFVQRELSSRQANYDQLMRLYSSESVNHREMKAKLHELQQELFRLRGQVPSTNVPPSETLSEKSSMWPSHPSYEMPEKKISPAPVEHTPKGNPFVEMMKGHESQNYDFAHLSHISARPTMTETRKAPTSFPVPESREDKRRPSGRNPPSGGGSDGGDDGGNDPFGNDGRGFRPDSGSHFSASRRKMDSMKLAPELTRTDNLSLKCFLMEFERLREDFMLSDSDVIGLFSYRIRKSGVAEIENWWARRARSQHDTNWDVVRNAFWQEFIYETSKKQVDELRHGTARKDGESIRMFASRLMLIGESNEMSDYLMVKIFKEQINDVTAYNFLKLARPEPRTVQACINLLDAYEIDTRSTDYRGSEDEGTSRTKRVSKSSSPPKSETDMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WEJ9</accession>
    <name>A0A6G0WEJ9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_015725</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000230">
        <property type="protein sequence ID" value="KAF0725955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WEJ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004035"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45911">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45911:SF7">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="5">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="5">
        <location>
            <begin position="150"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="479"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="402"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="343"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="489"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="505"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0725955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="515" mass="57196" checksum="12EE2384C9F09ACD" modified="2020-08-12" version="1">MAASMLGRSSTSGLRHILRVQLHKASDLAAGDFSLLGRHSSDPYVFFTVGNEKYKSTVVPKNINPTWEDATFDFHVTDGDLFTKVLDVQVFDQDNHDDDLLGSVAIPLAQFASQLPDQVRAKPYHLNVPAQFTKQKRNSQIFLTINLIEGGGGNDNPLAYIPRHLKVHLHKATDLAAADFALLGKGKSDPYVVFSIGSQRFKSETINKCLDPVWKDNPIFDFDLTQDDLFTQVLDIQVFDSDHGLSADDLIGTLSIPLAQFDNPTGDLRPRAYPLTVPDTYRRQNVHSQLYLTIEMDEKPDFIPPPPPTDETAEMIAQMQAEIAALKMSSQSIVHKMEAEIKPTPATPSSPSSTPTSQPDPESEGDLKKRALVNELHGLLHLPPIKTFTKLTHDPATTDGATLHWKNEVENLKAQLDQEKRLNDMLKSQSSDQSSQDEVERLKHEVAMHKATLAATQTMMEEQLRREAQTQEELKLLKTIAVRQIKPTPTSPPSPPPKAAAAEAGNDDEDESLWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WEK7</accession>
    <name>A0A6G0WEK7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutathione transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_016081</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000242">
        <property type="protein sequence ID" value="KAF0725440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WEK7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002425"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03192">
        <property type="entry name" value="GST_C_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03039">
        <property type="entry name" value="GST_N_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000030">
        <property type="entry name" value="Glutathione S-transferase S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF252">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="72"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0725440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="21725" checksum="13A6EE181AD503FB" modified="2020-08-12" version="1">MAGRAETTRLALHVGGIPFEDERIAREAWPELKPTLPYKQLPVLTVDGQVFSQSHAMARYAGVLSGLYPKDNAVDALRVDELCDFNEDILLAVVPTFREQDAEKRKAMSEDLAANKLPEMLAMLEARLAASKGLYVLDSISLADLSIYGTVSMFQSGWLENIPTDLCDKYAKIMAIYDAVSKHPKIVEWNEAHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WEV9</accession>
    <name>A0A6G0WEV9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_015593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000226">
        <property type="protein sequence ID" value="KAF0726080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WEV9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005472"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0726080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="223" mass="25816" checksum="A5D0E3F5746F810D" modified="2020-08-12" version="1">MSNDSVCTFNSSKITFVVRRELIFPSSAIPPSDTLSYLIRFPGGMFYSKGARDFIENYLGQDDMDRSHGSQFKCQRNMFYGTIFADSCVWLEPLSAGSTDTTYRAYFGTVVWEDKWWSWSKLVIRCLLTLCILCVLWQRYWRHYKPLMRSLQRIGVGDQRYCRYVIIAGDPTYMILSDPWVSLVMTMDIVITPAYASWSVLRVGQFNDLGTLSLGCLYSTRYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WF40</accession>
    <name>A0A6G0WF40_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_015973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000237">
        <property type="protein sequence ID" value="KAF0725640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WF40"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018497"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0725640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="407" mass="45190" checksum="2710A6EE8CD319D9" modified="2020-08-12" version="1">MAKRNTVCEPSVVLLPPNFVLGEEDDVVETLVDEILTNGGRMLYENYLNDSIIPYSTKWMWQALHELLGVVDMNKRCNGHVPSTFAHDGEPISIDLDNMSRAMVPVKPIHDSRYTMVLSSLDSNRDEHTERSQTVDDSVSVTSTVKTRAKTPTERVIVENIPIVPLQEPERDTEAYRQDDERRRTLLKAWEASQQDQVPSSPGNSRTSPRKRRMQKKAQSALPTITTASPVEMDDGAVLHIDFAIFDVKTVDGRLEKRPSSSASTCSRPSRQRIRTPTPTAVSSLSCDFEPSDLVGNVIKELVLARGVKLTSTGARINSSRQDNLPDMRASSAFHGNSIVTPPKPTSSTTSLVFEDRRQTDFGCRTLNTRMVSPTKPSQPDSKATSVRPATSPSPLAGRRRMTCFKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WF69</accession>
    <name>A0A6G0WF69_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Centrosomal protein of 44 kDa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_016119</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Centriole-enriched microtubule-binding protein involved in centriole biogenesis. In collaboration with CEP295 and POC1B, is required for the centriole-to-centrosome conversion by ensuring the formation of bona fide centriole wall. Functions as a linker component that maintains centrosome cohesion. Associates with CROCC and regulates its stability and localization to the centrosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Spindle pole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Midbody</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000243">
        <property type="protein sequence ID" value="KAF0725347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WF69"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002252"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033603">
        <property type="entry name" value="CEP44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029157">
        <property type="entry name" value="CEP44_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31477">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 44 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31477:SF1">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 44 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15007">
        <property type="entry name" value="CEP44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centrosomal CEP44" evidence="10">
        <location>
            <begin position="5"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="235"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF15007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0725347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="328" mass="37625" checksum="3F0E2D2756FBD173" modified="2020-08-12" version="1">MATGDMENNGAKVRKQLQAIQYPHDVTLSVESLMRGAPDDHLAELLRILHYAFLDHSRHVAQLVQDAGFDLYGKTDVRFVDGVFRFAREKLSYFPHLTTPQFLSPRHYRETKLILLADLLALVAKTHAEAAKREKQRQAVWIPPSNKSQNVISAPHHVHPAEVEDAKITHPRVSINLGQPKHPKHPARVVRHERHSFISDDISLPRQETPTEEPPVIDWKTQIEGTAYPDLDKNILQPSNEQPKMWWSQPPTPPPNNQHEEELEEEDMNPRKSFDVAPEPKPPVLSPMKPVDIRAELAQVEINLSSKLDMMMRLFEAKLHPRSRFDPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WFT0</accession>
    <name>A0A6G0WFT0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TNase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_015972</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000237">
        <property type="protein sequence ID" value="KAF0725639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WFT0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018496"/>
    <dbReference type="OrthoDB" id="430293at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302">
        <property type="entry name" value="EBNA2 BINDING PROTEIN P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="Staphylococcal nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50830">
        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="5">
        <location>
            <begin position="51"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0725639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="200" mass="22648" checksum="6ADC9F784E849733" modified="2020-08-12" version="1">MLTTTWRNGWDYVGVFILGVIAGYILPRFMLHLRRYETVKDIPETCFEQNATFRGQVVAVSDGDTFRVRHVPFFRGAGSYDGKMTDHTLQIRLAGIDTPELPHFGRECQPYAREAKAWLESAIKGATVTIQLLRRDQYGRAVCMVTQGTWPFTKNLSDELLKVGLAKVYRLSGAVYGGRLDLFNALEAQAKQARLNVWSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WG93</accession>
    <name>A0A6G0WG93_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_015736</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000231">
        <property type="protein sequence ID" value="KAF0725885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WG93"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018714"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF214">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="353"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="413"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0725885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="589" mass="66513" checksum="94BA9A2F7850CF26" modified="2020-08-12" version="1">MLAAACPHSSLQAYVGQILVKSDVYCNRNDTRCVIHRNCSYAGQSMPSSFGGVQWQAIGNFENYTNSTLYRDSRGQFTSRYKIDGFARFNHNLIASSDDDEVPSVWPTKLTNSSMIDCRLFDTEGAHLSNAIDYLRNLSYLVLSSNSKLTSLSNLHLNHLEFFNLSSNPKLTSLSNLSLNGLHYFDLSSNFMLTNLSDVDLVSLNNFNLLSNSKLTSMSNVYLHSLSYFNLSSKSELTSLTNLYLPSLQRFDLSSNSKLTRLQNQMFGENLLFLNMSNLSLKSWSMDKKTYDALNSMTEAPASGDLKNGRYVIKPLKIDMGEKECEYNAFKLWTNDRPNVCVYLFASDSPWDALFLTFVSILAFALVIACGTMGPKWIKRIRERRKQRKIEAAAYSGIDMTPLTKVRIELKKLKMHEILGCGAFADVCRGTFQDEVVAVKVLQSNRTSLQQLKAFVDEINLMASFDSPYIVKLIGAAWTRPLDILCVMEFMDSGDLKNYLDSHKKLSWAEKILHLLCIAEGLVYLHSIDIIHRDIKSRNVLLDSTKGTQLTDFGISKEDIQATMTGRFDGWLQKFSKTSTILSRPTSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WG98</accession>
    <name>A0A6G0WG98_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_015789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000232">
        <property type="protein sequence ID" value="KAF0725827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WG98"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0725827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="85" mass="9961" checksum="68E11F6CB69A3CBB" modified="2020-08-12" version="1">MRSNLAQDSVFGANARLYLRRLILSIVSVRANDTPYRVFPSHNPEQAHRHESRRASRHPSPFPNCRHSKTCNHRDRLADHFVREC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WGI2</accession>
    <name>A0A6G0WGI2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">microtubule-severing ATPase</fullName>
            <ecNumber evidence="9">5.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ae201684_015462</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers.</text>
            <dbReference type="EC" id="5.6.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.1" evidence="9"/>
    <dbReference type="EMBL" id="VJMJ01000220">
        <property type="protein sequence ID" value="KAF0726244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WGI2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007896"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008568">
        <property type="term" value="F:microtubule severing ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd19509">
        <property type="entry name" value="RecA-like_VPS4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001054">
        <property type="entry name" value="ATPase, AAA family, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000022">
        <property type="entry name" value="Fidgetin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF86">
        <property type="entry name" value="SPASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04212">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00745">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIT" evidence="13">
        <location>
            <begin position="18"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="169"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00036378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF0726244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="434" mass="48127" checksum="2E9643D3B5CD40E4" modified="2020-08-12" version="1">MFSFLRRASPGTTKPLSDPDPVRALAAKAITTDERGEYNAAVELYTELIDKLLTKLKDTPDGEKHRDLRKEIERYMSRAEYIKSLSKEPKTTNAKVEISATFPTAQATKSNERKTSALIARNDPICHLILDEVLDKSPGVTWDDIAGLDEAKQMLQEAVVLPTLRLCAPPKGALLFGPPGTGKTMLAKAVATESNATFFSITASSLTSKWVGEGEKLVRALFEMAKELQPSVIFVDEIDSLLSSRSSGEHDASRRIKNEFFTQLDGATSTSHERILVLGATNLPQELDEAIIRRLEKRIYVSLPDVAARRYLIEHLLKLHQHTLTKADINVIAEATSKFSGSDVRNLCKEAAMGPLRSLGAFVQVLDDLLLPIHARDDETGATWISYSYTTFTKHGCDVQKLDIWFMSEQRGNAYARAKDIFICVVLVESFALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WGU9</accession>
    <name>A0A6G0WGU9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_015349</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000217">
        <property type="protein sequence ID" value="KAF0726381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WGU9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005432"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020564"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1070">
        <property type="entry name" value="Zinc finger, BED domain-containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052717">
        <property type="entry name" value="Vacuolar_transposase_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46169">
        <property type="entry name" value="DNA REPLICATION-RELATED ELEMENT FACTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46169:SF15">
        <property type="entry name" value="INNER CENTROMERE PROTEIN A-LIKE ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140996">
        <property type="entry name" value="Hermes dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="2">
        <location>
            <begin position="559"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="497"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0726381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="628" mass="71009" checksum="6407B0E9D6DD02B4" modified="2020-08-12" version="1">MEDVKKSLVQSLTSKTPAHVLVKPSRQSIPRVPSNSSCWSKFSWVYNKESNKAETFVDDKNVKKTYVACNSCKEVYLYSGINGTSSLNAHKCYTMANDPSIGGVAAYFTKPGDLRPFHIVAGNGFRGVIQTALDLGFQSKQPLLARDVLPDRTTVKRNCTSRKEASYTLLIKNVHRHITDGLWLGATTDLWTDDDRRSRTFRLHCTESTSISALMIYLGQLQCYFGSVYHTDNASNNSASDGLPSEYTRIVCADHKIDTCVSYVLKRRTRQINGVRSQPFYEYYDEAPLLFDHITNCKKAVTAAKQCGFHKSITPKLQQEITTRWYGLYSMLNSFEGTQRMAELMETFSKNKRQTLILSLEKELNTEMVRFFLLFKQATLALECFKKPMFHLVAFWRQKLLSHCIRITEPRNINDDNAVDTELMPDSDDMAAIKLRIHEQISAKFTIEPLHVVAAMLDPRQKHRLQKMGITDDQARRGKLDLKALMLQFSTHTSVASYSKSSDSTNSSDDNGCEGSDDDNNAQANANSLLAIDKELLDYMPLKLTQDEKALLDRHDLPQGGLLSWWRGRAATFPHLARVVRSVLKIPASTAKSECNFSDAANTLTPKRNQLSPNTVDTLLFMRSNIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WH38</accession>
    <name>A0A6G0WH38_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_015278</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000215">
        <property type="protein sequence ID" value="KAF0726464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WH38"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013910"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0726464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="350" mass="40377" checksum="9AF9DC941A2D5E9B" modified="2020-08-12" version="1">MSRQAIRSVLTSADIFPYLMAYQHGLSEDFLPFLPLRNVLTQQGGPKQAKFFISRYIHVVHRWYIYHGAAAAARLERLVLTLPWTCELVFLYGIYVGDKEIVTAPALESYRRWTASMPRLVAAAVASDNVFRAIECLECFCLNRMDILVGVGDAVSRGRPLLAEYLAARNEKGLLASSFQRRRIHDHLQEIYRSNHLEYLPWLLQFWDRWFPPRWKTHNLQECCKLAMEHQLWNLLVDFTKCAKLQYKEAMLYAAQESLIVAVEWLVENTWVVIDHTHIVAAAKAWRPDDKTSEKNSTACSPFGSRRNVCTESKRHGIAMCMEEAMKQPDRGLMDFLLTTNVDLYSARSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WI50</accession>
    <name>A0A6G0WI50_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Plastocyanin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_014999</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000205">
        <property type="protein sequence ID" value="KAF0726857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WI50"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019492"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48267:SF1">
        <property type="entry name" value="BILIRUBIN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48267">
        <property type="entry name" value="CUPREDOXIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="5">
        <location>
            <begin position="87"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="4">
        <location>
            <begin position="370"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0726857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="505" mass="56347" checksum="DCC8E57FB6D5F5A3" modified="2020-08-12" version="1">MVIGTTNQSWGEGANISGLQYGYGQVGTVVTSPGPTIIAKRTVAFKVNWHNHLGIKPHLLSLNVVPSLLDDTESACYNQEDTKCGVPVVVHVHGLENPPEFDGLPHATVFNNQTFTTIYRNSQQPSFKIYHDHALGLSRLNKWAGLVGAYIVQDPEIDAAFNLTDLPDYVLAIQDKLISSNGALLYPDEAACVSKKWLPESYGNVNTVNGVVMPFLQVEARQVRFRWANVANARVYSFDLTAFGDQCLVIATDGGYVHKPKPIPLTHGGQRLLQLYPLERVEMVCDFTSTPVGSVFNISNTHAIESSYPYDPRVLQIQIKATSTTTKNIIPQTLTEYKDLGDLFHQTNGLVRRIKLGQMNDPKECPTHFYMKQFGQELNISTIRHTMHCTLGKVEQWIFTNPSHTSHPFHWHLVNAQCGPTEDSIDANSLKDVVEIPSNAHGHPTQVCYVACMPNEALVKGSHRDPTDFGTEVTKDPYLAHCHIIEHQENAMMAWFRITRTDVVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WIN4</accession>
    <name>A0A6G0WIN4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_014802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000202">
        <property type="protein sequence ID" value="KAF0727063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WIN4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001530"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="29"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0727063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="271" mass="29629" checksum="A3E6A8533222E577" modified="2020-08-12" version="1">MPKPSSRSSRRSSTKQATPPTLSHAFLLAATKYAGSPALHYQQPNGHWLHYSWNEVRYNSIQFAKALLSQGFVPGDQVAIVGGTSPSWYFAYFGCILAGGVAVGMASPSEQALLLEASARFLVVDSFDQLNALAKPCIPQLEAIVVWDLELQDTANCSNYSIPLFDFETFVAWGDDLADSVVQRIVNAQQSNDPIALVSTKLLVAATNLICFPMPRSRTLHPGCRILCKPETSRGFNFHTAISTTVLRTLLSRPHPSQIQTLHDESAIGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJ26</accession>
    <name>A0A6G0WJ26_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_014752</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000200">
        <property type="protein sequence ID" value="KAF0727224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJ26"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000136"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0727224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="201" mass="22330" checksum="55314C8800EBE62A" modified="2020-08-12" version="1">METTLLSTDEVALPLIQAPLDMSLNLDDDSQTIISLPSLSPRDEELRSAMPLHERLSGKGFSLMRRRSRSVRDLRLDTARATEKLTRTKTLSNLSTSPNNGLSAEKAMDMLGVTEETMRIEKGMKKLGICDHDIAASLEIRRHCGVILKEPETKKEAVLGFSIEQVNRIKAINMLGTSESEILDVYCKQMSDLGVPHSTHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJT7</accession>
    <name>A0A6G0WJT7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphatidate phosphatase APP1 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_014511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000194">
        <property type="protein sequence ID" value="KAF0727490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJT7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001685"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019236">
        <property type="entry name" value="APP1_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40861">
        <property type="entry name" value="DUF2183 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40861:SF1">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1 CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09949">
        <property type="entry name" value="APP1_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidate phosphatase APP1 catalytic" evidence="1">
        <location>
            <begin position="208"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0727490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="441" mass="49417" checksum="5B02AC072C010860" modified="2020-08-12" version="1">MKQRTSWRFKQRKSGVVFQVDGEDAEDEMYIRTANVPLTDEKYCHNVLANASPEMLNGILGAISPEGSDRFCANMTGFMLHSCNSDVRSKVLNVITNERLDDISLANRGIIIRAIQQELMSPLTRQRDVFQKSAFNVLRGTFGTDLTLLKEDINSDLEPCPMANSFKGGDLYQLIYGCPDLTQVVSIVQHIAVESLKVESQYKDKSLIKIISDIDDTLFPGWADKRYPNHILYPGVAQLYQTMSRGVDSRSPSVTFLTARPRGWFSFGRNLTADRLISLGVSNPTVLNGSVRTGTSADKIAGLKLDNFVRYATLFPEYKFIFFGDCGQGDALLASQMLQLFPEKMLGVFIHDIDPANPVTGDGETKAVYKDQGIVFYENYAAAGIAAYERGLLTRERLDDVIQSCQNELDKLTFKGPNANEKYTQRKLELLKECDRLVKYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJW1</accession>
    <name>A0A6G0WJW1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_014375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000193">
        <property type="protein sequence ID" value="KAF0727547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJW1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014095"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="18"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="191"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0727547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="683" mass="77823" checksum="33580A2385779AEF" modified="2020-08-12" version="1">MSDLRDAFKAITLLKDALTKKKQELAVCKAQMKEQEEQHLLDIQTLQEELNRTKAAVSLTCQHHGQGLEALQRQHAIELKKLRDELEIAVQFSQRNEEARIELATELQTQKQINNTQRLELHKLKESAASLQSQLEAQIAATSELSNSFSALQVESTSLKETIVDLNMQLHGKDQELTALHDQTSTLRHELNSAKSSIASLKAELDSKRQLAHSLEAKIIQLQVDKVQQDDEIVSLQQSLAQKRDEVRRFYAVNEPEATTATPELETTAVHKAKMEAKYLEWQQSVRLFSTDLQAIKQDVQEMSTYGLSALDHLHGQLPSHDKLQAALQSVRNLRGDCDLLKQGWTASMSVTLIWLETHVQTQLESWIQREREEMRRKTTFKLAEASEVLENLRGELDHAKDEWKATLQHTSEQHAIEMLILSDRIRVALPRSEALERHLMALEDTSSPYFRKLSPSTASSWQNLEATLRELKSPFHRLLQTLERANYLLKLLIRNADALQPLRSRALEKHAVGFADLIKALVVALDDATLAGTVAQYTNVVHETLYSWHACDSSYLDGIPVPSFGMESPVVDHVLTSWTANVSHRTDASEWLCAVFMDHPTSGSTFYFENLTREVKDAFLVLIVPLIKSKRQLVVHMKRQEVTDDRWDLKMEVLQSYPSPNQTEPQSAMFKAIERRLSQLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WKN7</accession>
    <name>A0A6G0WKN7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Biogenesis of lysosome-related organelles complex 1 subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_014245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000188">
        <property type="protein sequence ID" value="KAF0727810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WKN7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016285"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="100"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="24"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0727810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="138" mass="15310" checksum="C266EFA4027BA1EA" modified="2020-08-12" version="1">MGQGASLVRTIVSDVREIVAATNKDAYLKQYNAYKEASARLEAAKMGNAALQQQLEMTKLDVYSQSEALRQQKEQMDHQIDEFANMYAIDGEFFDKHRRHAKEVKEQVAKVGHDDTHDSKGESAAAQPKKDGGATSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WMJ8</accession>
    <name>A0A6G0WMJ8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_013532</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000175">
        <property type="protein sequence ID" value="KAF0728569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WMJ8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000432"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 2" id="KW-0371">Homeobox</keyword>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="4">
        <location>
            <begin position="121"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="1">
        <location>
            <begin position="123"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="36"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="370"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="370"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="386"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0728569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="409" mass="45621" checksum="CD42B0805F883FED" modified="2020-08-12" version="1">MEENFGEDDLTVDLEELGENTLDMMQIPMPLDIPFPGGAAATGSTASGAASAAPGSATGPIPSGETEFAHVMKTDDLIDYSSSSHIRQRGMRRALKVAPVARYFPLVPPPSYSPPGNNIKSAQQQLALKLAFLRNPHPTREDIVEMALRYGLTSNEITAWFKGERHRFKKKGGIVIPGNAGLEAWQMAMEDVQAPRTRHRAVSTKVAEERAERASELRRLLTPSQLKRSRAWAEDYANVMDSNEREFRIAQLVDRQDVRLKKEFRGFVVQEPSLGLRLDQEFKARKSCADPTCGREVVAERADSCWEFMRSRFGSTMFSFGERYVDNEGNILLDASLLSGLEMMFMRHRDYFMALVHRFNIREFFEEAAQKRPRTDEGPPDVKGDTATLPAQPTTAPGSSTTSGQSVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WMY1</accession>
    <name>A0A6G0WMY1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transmembrane protein 198</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_013658</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM198 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000175">
        <property type="protein sequence ID" value="KAF0728700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WMY1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002488"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025256">
        <property type="entry name" value="TM7S3/TM198-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040236">
        <property type="entry name" value="TMEM198"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31247:SF5">
        <property type="entry name" value="DUF4203 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31247">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 198 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13886">
        <property type="entry name" value="TM7S3_TM198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="TM7S3/TM198-like" evidence="9">
        <location>
            <begin position="88"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0728700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="329" mass="35802" checksum="315D4FDBB995B48B" modified="2020-08-12" version="1">MFLSNRGDEPLLGPPFARKRISGPSNWSKFQNTLVLGLSVLALGLMGVFMLSANTDQEIVSSAKYLEAPANLTTNPLGDVAPDVIYGMTIFGGVLLGFFGYRFIRAAFFVAGFTIGLVVFFDIGTQAFRNESWIVAGSLSLSIVGAILLALLTLYLYRFGVAVLGVLAGIGFGAFLGSIFFIQFNSVHPEIPMFLSMACFGIFFGLVAFFEEKPVVILCTSFLGSFFMVLGAGNFIGQYPTPANIKELLDELRRQENVRMPGAWWAYFAVTLVLWIVCIAAQVQITANGVDHSNDVEAPPRRPPRPPQTTINISNGVPKKASFKVERGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WPG0</accession>
    <name>A0A6G0WPG0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_013034</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000166">
        <property type="protein sequence ID" value="KAF0729288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WPG0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014971"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031851">
        <property type="entry name" value="DUF4750"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15938">
        <property type="entry name" value="DUF4750"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0729288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="94" mass="10610" checksum="5EF8F831040FA2A4" modified="2020-08-12" version="1">MDDYVMRAAYVAGAMSIVLVTLALGWVTVWKLLLSRISFIRELLDMNPKKPAAPTPSTSRKPTSFDERLREYKENPHRRHTGSTLMAPSASHKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WRB2</accession>
    <name>A0A6G0WRB2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_012569</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000159">
        <property type="protein sequence ID" value="KAF0729930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WRB2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002618"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF214">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="77"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0729930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="351" mass="38378" checksum="E090BBE87F51F9E4" modified="2020-08-12" version="1">MGCSSSTEAAAPINRPAAPAPTNNNNNATNGKSFGTTAAPSIRNLVATQNTAGPIDWSQYTELEPYKEKFWVDIEDLTIVRPLKSSYMKTEMGNLHGESVLLKSIDNAAPADEIAKSRKALVSEITSMARISHPNIVGFKGFSISPEMGLVCISEYMEAKTLRVLLDNPKQFAKLTWANEKINFAIDICSALCYMHSLKPTLIHRNVKAQKVLLNKSRTQAKLSGFGASRDRSFEQEMTNKIGEIEWSAPELIMEDEDYTEKIDVYSFGVLLTELDTGALPFADVKDTMHSTAFTNKLVSGALRPQLSPDCPPAIVKVVKSCLQQDPHIRPTSAKVLELLNAAKAEMAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WS54</accession>
    <name>A0A6G0WS54_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_012258</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000155">
        <property type="protein sequence ID" value="KAF0730256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WS54"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0730256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="209" mass="22786" checksum="173C678DF2C6BD54" modified="2020-08-12" version="1">MFAWNVHIPSIRIATLRSVGRLTELLRRPCCYPVPPSSPEATAPSSEFLAWKTKAASPTTLEITQSPRLTSVASKNVHVSEELSIAAISAAKARPIKETFHRVALSLANTTRARQESHVGGEHGFPASINAIRPETSVVAFHLSHPSILVLPLAATTRRQQRARIQVVGSDRKNPIVAATAAAYEGAYLYRHRRRAAVKQPKAVSPVHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WT34</accession>
    <name>A0A6G0WT34_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_012070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000153">
        <property type="protein sequence ID" value="KAF0730651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WT34"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013136"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0730651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="95" mass="10153" checksum="AE1A945F80C2C829" modified="2020-08-12" version="1">MENPTPSATAPPTAKELRAALQGCMIQNQVAFCVGGVLAGMPISIYSKKMYPFAVLGVLGSFIDYSYPYNSKCVEISQALDAALAREQTTSSDKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WT96</accession>
    <name>A0A6G0WT96_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_012081</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000153">
        <property type="protein sequence ID" value="KAF0730662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WT96"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011710"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0730662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="282" mass="31730" checksum="6F68F6AEC5E0937B" modified="2020-08-12" version="1">MGNAPSSDFLIDFQAATTVKAHYTASNCRFSIKKQTLAIAFDHGKTPPKTLNVRHVHIKPIDGKSYELRYKEDLVVVLPTPSQSRFDAFLRVLDLAKATKESTLPPTTTQLMDVAVAISQTFEAKRSIIPSIPISNMTVDKVQAHLAEMQAMYKTLTTCNSNEDLYELLLEFEAAYVADREINNFAHTVHKLHPKQYQLHQQLRQQPLLASSLKTSLQWILKPCPSCKQNLSITVMFAVHMQGKTEKCPHCTTTFSYESFHVAQLITHCGTQRVHETASNSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WVC1</accession>
    <name>A0A6G0WVC1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_011327</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000143">
        <property type="protein sequence ID" value="KAF0731426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WVC1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003013"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052050">
        <property type="entry name" value="SecEffector_AnkRepeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586:SF3">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0731426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="254" mass="29130" checksum="EFE6C514B1DB3368" modified="2020-08-12" version="1">MQQVCGTTDIMRSIFAFQPGYPQPMLPFIQYFDANLEALDEILRSYLDMESRLSPYRVDSLLYYFPQLAHNFYCYAVWAENLDLLGLMLQRGMTMLYHATEIAAFLGRVKVLTYLEEHNLATYSTQTLNWACRQGHFNAVEFLHPHIAMGDTVAMDAAATNGHFEIVKFLHVYRDEGCTTTAMDQAAANGHLEIMKFLHYNRTEGATTKVMTLAASHGHLDVVKFLYEHRSEGCTLRALHGSRESKYRLHNQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WVV6</accession>
    <name>A0A6G0WVV6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_010981</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000140">
        <property type="protein sequence ID" value="KAF0731675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WVV6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011927"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0731675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="199" mass="20993" checksum="96B82563CBCD323E" modified="2020-08-12" version="1">MSVNDINESTAAVTPVEEKTVTPVEEKAVSSNPLSSLTSLVGDQVENANQVTAAARHNITKAAGMIWTTVKKPVTEAIQVIRDANSKTGTPLRKSIADVRLTVNDTLVSVESSVKEAETSIEKNLEPVKDAFAVAQENLVKFNTFRKAYPAVVVGGAALIVGLPTLLRSGKGRALFNSVAAAGVTAGAMYGADEWEKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WWV7</accession>
    <name>A0A6G0WWV7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_010675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000137">
        <property type="protein sequence ID" value="KAF0732022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WWV7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016385"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0732022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="309" mass="34580" checksum="4DC9E8BAD46377E5" modified="2020-08-12" version="1">MPVAIHETLRNFLSLAKGERVPPHFIGSLAACLFPNTSVVETPVLYVIREDSIDVFNREASLKVDNVLGLVYGLVAQNRLEKLRFWFPPSLSGDQVRQVLLRLLPHTTKGLEPDSVLFSALDSAYYMMVQELARKVEWKNDEGYRLYVLDAAVTITDVGIGSTWEIDGETFEMDAVHIADAPILLSQTEIPYDQDYMVTLINHPVVSKLIRVVRLVSTKQPVAWSLVHCDFSIGLLSTLPEYRRKGLVQRALSSTIVAYRDVAASHDGLLGIEPHCFVSVENVPSQKLMASVGFEYIPDKTFHWLAAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WXH7</accession>
    <name>A0A6G0WXH7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_010834</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000137">
        <property type="protein sequence ID" value="KAF0732185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WXH7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002029"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00469">
        <property type="entry name" value="TrhO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022111">
        <property type="entry name" value="Rhodanese_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020936">
        <property type="entry name" value="TrhO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040503">
        <property type="entry name" value="TRHO_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43268">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE/RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43268:SF6">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE_RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12368">
        <property type="entry name" value="Rhodanese_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17773">
        <property type="entry name" value="UPF0176_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="157"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="336"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0732185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="420" mass="47351" checksum="9401FAD8E276344E" modified="2020-08-12" version="1">MATEVAETVSQGDAKRLKVADTTEPADYHVILFYKYVEVPDPMAEKTAQHDKCVDLGLLGRSLVSEEGINATFAGSLDKINEYVKYMCEHPVFDMTTEDFKRSMVVDHAPFSELVIKYVKEIVNTGGSVKPPPATMTDEQRGYLTPEQFHAAMAEKDSTKTVVLDVRAHKEFLVGHFKDALDPQVKNFSEYYTFLDHHIENFKKEKPKVLMYCTGGIRCEKASQFLRSRGVTDVHHLKGGIHKYLEKFPDGGFFKGKNFVFDKRVLMGPEQSEVVGTCIECKSPYDTFSGGKVCSVCRDLLLACDACYQARYGEVHCDDHQYLKDCYFTFLQYFTADELSAQVTALEAIHTSLLEETDAAKRSKNKRRTVRKQIEKVQARLAAVQADPSIVQARTGKVHCRTCGSTDCAGNCWGFWNEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WZR7</accession>
    <name>A0A6G0WZR7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_009925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000126">
        <property type="protein sequence ID" value="KAF0733103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WZR7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011237"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0733103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="514" mass="57406" checksum="CECA445C6CBC53D1" modified="2020-08-12" version="1">MAMTCDGSMLELQFLKLTDTLNGMQSRLESLQEQVDGLPDRIWQNLDNRGAMSPGISTAPLVQTAIKALTDAILQSVNIKTEPTESTPTFEPALIDPEPATVNIPPEVEDTVMEEDPPVVEMPPTSTASTTSSSSSDEKSDSVMPSNSFLAVSANQGVQMSTAPLRLKSLRPTPRHVPSICLPPSAIRMPELSISWMSNGSNDMPCRKRKSSSPLVSKKIHKTNQDRDNDFAFFEWSDGTMRLAPQDWHFPKVSCRSMWRFWFRGDSTRRICPFRRLTSRDLATHTTRRAKFWAKHVMEKLIQLAISHGAATSVESIEASSDSALMCIFDTAFEALLQSIPRSTKRPPSHLSTCFAVFYTLHRKKKPTMAHDEDQDGLFQWTDGSKRRAPEGWTFPVISCRTLWHRWYLGDDTAHIGPYQFLAASDLSNEDSRRHRQQAEAIMLQLAQIAVAKGLVDAVEHMDVLAPGASDLVLQQSLAVLVKDLACEDVGNELNLTYETVWTAMEEAKQVRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WZS2</accession>
    <name>A0A6G0WZS2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_009846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000126">
        <property type="protein sequence ID" value="KAF0733019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WZS2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001768"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1058"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1065"/>
            <end position="1084"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0733019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1126" mass="127449" checksum="D12C1060BB4D7C0F" modified="2020-08-12" version="1">MESLEALRRSSLRYVLDVAPSMLRESEQVSDVLIERIRSQQESEEGVNAILRLMSLHLQSNARVTEQLVELLYTSDFRVSIIHHLPKLTYQSKPCMVLVIQAYRDLLETDGALVVPILGSLADMPLSPEQQNQVVDMTHALMDSIAEEDIPAVVRGLLAMLTSANADLVIGSIRTQCLQLATHTLLLVVEVMGRYLRSGSISLKYIMRAIRNTDTLMPIDGLWLLLLMQHDSKHAWSCMAQLGRKCSASWLESIAMVALESPETLLPLFTQFCMLIVQLAFQKSTLVGLRHDLIFVATQSVAFLLQHTRGLAQQEVLVTLLTLASQSHKITTTTKQADLRGHLARTAAVCIADNVAAIPSYGYLILDTVHHLSMAKEFLLNVVDPLCFGLVQLITQDPSLYSLVLLTIQKHILMPSNFQITAMLLSSHLSYAKQLEPMDQRAISKWMYRLFHTASPSVVPFICSFLCVQVERELCQILPALVRRRILTPKAPHTFSLDRFVRAENDAELSTEQLHALLDMTYTLVLHSDEHTLDALLASVPQVEECDDDGIRQCSLMIAIAICNGLDHIQLRVESIPKYFQLAYDLAKSLEMWPTLCFLQQDLVLGLSHALPIPSLHVLFLMLRQRPTDFRWQLYGTYTLHNPKKYLDHLPHWLDLIVDFGHHEKQPTHAETLLQLYSIFLQLLQEDSADNVIKALVPSAPSTEEARAQVFAVLKEQAMEQLQDAQAIVPLLDLLVVTAGSNPTLIGDTAYLAQAIYGHVFPDAALDLTLWKTYLDRPAASFHLTSTTFLKPPSPFASSTHYMYHAMVTAYALHPQPLQFLQGVLSTLQEMVDQAIDHCHPEVRSVTTDSFRFAFVSYWLCLLNFCPRGAQIPKQLDVRNPYIPCIQLFALLESSFAFLPRANEYDAEASFAQKTIVLMLRACQVVCEQMIKCVDRCLRWRVGVDISDDSGNVRHLSPLLYQMEFVLSAMEVYVQGMQRYALRQLKEAAKPTKTKLQQFVKKQRVVQPLPQIKFMPQVLRWIQRTKEAIAKTQTQYSIPPGSDMDLQELVQTQATFHQWNHHDSDEEEEKENESSPEDDEEYNPADDFHVMHTDVTALQTPQKALADNDSFGFPSIVIDFKQLKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X058</accession>
    <name>A0A6G0X058_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_009803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000124">
        <property type="protein sequence ID" value="KAF0733239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X058"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005384"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15457">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.40">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012816">
        <property type="entry name" value="NADAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037238">
        <property type="entry name" value="YbiA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02464">
        <property type="entry name" value="ribofla_fusion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08719">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143990">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADAR" evidence="1">
        <location>
            <begin position="39"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0733239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="189" mass="20506" checksum="8E912265AE0D5CDE" modified="2020-08-12" version="1">MTLPTTRADLVQAVQEGHSFDFHVFFGQNPIAATGADVESNFLSQAFPAHFVVDGKRYATAEHYMMAQKAYLFGDSVIGDRIVETNDPNEAKALGRQAQGFNAELWTAHRSTIVETGNRAKFSEPANAHLKALLLTTGSKVLVDATPTDKLWATGLSSESPDVVIPDKWPGLNLLGFALMSVRSSLAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X0K4</accession>
    <name>A0A6G0X0K4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_009581</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000122">
        <property type="protein sequence ID" value="KAF0733331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X0K4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013162"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050498">
        <property type="entry name" value="Ycf3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44858">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44858:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE SPINDLY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="10"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="150"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="426"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="529"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="566"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0733331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="697" mass="78576" checksum="5AF080C332B6CCE8" modified="2020-08-12" version="1">MAISIRPNHARYFSSRGNSFRSINEHETAVKDFTMAIELEPECPTYYANRGASRRKLSQTADALEDFTIAIELDTKKGNHYFNRASVLSDAGYYAEAIVDFTKALEDSSGGPRMEFRALHSRGNCYRRMGNLKLCEADMLQAIKLEPRNPVGYNSLGQCYIEFSDVDNAVKNFTSAINLQDSNATYLNNRGQALFRQGRDSFRAALIDFNAAIKVDGKDPQAYYNRGLARLAIAFEEIVKKDNAKHAADVKLAMTEPGDSDDEGCKDATSKLLLLSTTSQKELENPMPNSAQLTGVMSAEEQLEAAIADLDMACALEPKSTRYLYGKAMIEHLKALRLADVQETKTTLQAVLRNDPAHIASRYHLAMLYHAEKKFDNAVEELTDLIDRIPTEPRFYQARGLVFQEIGMHELAIDDFTTALSTTSTSIYLYHRGESFLRLGHFQKAVDDLTAAIHLDSKATAAMYNARGLAQRHLGLFDEAIADLTMCIDLHKRNACYRLHRSLCYIDTKQYERALDDLNVGLRLTPRDSRLLYNAGLASFHLRDFEDSINKLMQALKYNPPEETLSDLYYHLGLGFANLDEHMQAVEFFTYAIDQTTSRQCKIKYVHERAKALQLEGYHEEAIVDFSLVLHHNPTNAHAHFRRAFAYKALGDLQACADDLEKAKLLDPLNPKLVTNYKALHDIECVVLCAPGQETEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X1P3</accession>
    <name>A0A6G0X1P3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin-activating enzyme E1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_009382</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000119">
        <property type="protein sequence ID" value="KAF0733817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X1P3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010138"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.180">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, FCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.80">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12550">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032420">
        <property type="entry name" value="E1_4HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042302">
        <property type="entry name" value="E1_FCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042449">
        <property type="entry name" value="Ub-E1_IAD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF102">
        <property type="entry name" value="ADENYLYLTRANSFERASE AND SULFURTRANSFERASE MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16191">
        <property type="entry name" value="E1_4HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="3">
        <location>
            <begin position="12"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-activating enzyme E1 four-helix bundle" evidence="4">
        <location>
            <begin position="281"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="3">
        <location>
            <begin position="444"/>
            <end position="865"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0733817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1015" mass="111751" checksum="E4F3AB74D3823A69" modified="2020-08-12" version="1">MAASASPRDHYTRPLLAFGSKWMKSIAMMKVLVVGLRGLGVDVGKRKACLESDVDVAVRNLMCHGVNAIALLDDDCLREDDIASSTFFDISDVGRKKSVVVKARLAHLNAATRLSTLSGILTSDLLLNYHAVVVTSGPLSREEIAGLSEFCRMQEPPIGVVVAESRGLLASIFVDFGHSHIAEEDESPEFTIVNLDVVGGIVHVREPYIQHMIQAGDLVEFAFCQSPQADAAWLHKLQLLVVEVLSLTALRVHFGVSRLTSFHLNDLPRLKLHKVYGCRSIAHMSYRENIVKPQLVECPYYFAAKDTGRAKQLHAVLQGLYTFRQHHGFFPQPNNIGHGNEILKLTQDFVAQTNSVAASNGLAHAFDPVNATLALEVARCASVEFHPLSACVAGMACIELFKFCFGCPLTQVMHWDVLDVLPPVKDLKKETIFHDAARLRESSMLAMFGNEALTRLKHARILVVGCGSVGCEAIQNLSLMGVGTSGPGNVVIDGNQVKLHDVTTQSLFRGDDVGQNKAKVASTRHAKWHPIPAPLQMDDPNIDDKLWTSLDAVVATVEASFIQQLVDEQCFVNEKSVVSGFSTGMTGTVRVYEPHTTQRWVEGQLQDDSASLFLVDRIAMLKASIKPPQPSLAHPIDVTRAFESHRVVRWARTLYDDVFVQSLSCLKLAWTDKINGRSKRRDATFYEFACQAYVRCQALKSVAACIDVAMHVFQTALAPFNVSFNCNDPTHAAFVQVCAVLLSHTMALPMFQDVSLETCRREPLGTPSTLSSTLSAEDFQALSATEMEPVVEPSRVMPFDVMNDSNRHVLFVQTAANVAASVLGIRPIGFFPCKALCGCRADSTATAAIVGGLASIEVVKAVLRKSTCLRQSDYRVFSGLLAFGVPPPPQPLQSIALDATRGTPLRVCPANITLWRKLVVQCTLVPRLLTVEDFLRYLKTKYEVHVERILWRQHSLFATNEQAKLKSSVFELWKAVTGRQSESPRFLMLDIHSRDNDGDVVLPSIQLLAPRDDTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X1S0</accession>
    <name>A0A6G0X1S0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_009296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000119">
        <property type="protein sequence ID" value="KAF0733724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X1S0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012324"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051026">
        <property type="entry name" value="PI/PC_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657:SF1">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="99"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0733724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="331" mass="37354" checksum="AC869891D9FCF205" modified="2020-08-12" version="1">MTVKGLNKEAVFDSFKAKVLQEFPEADLEASGVVVKGFLDSTLTRYLEARNYVENDSLKMFRDTMAWRTQNNVSTALDRLLPQEKVDALRKYHVSPCYAEQTSRCLQPQGEHGVDREGNVLYVERIGYLDAETLMKHVTLEEAVEYHIQKYEFQHHVTFKDASAQQGRIVNKMTVIYDLENVGMHTFKKVVFDFVKQTSAIGQDHYPDTLSKVFIVNAPFFFFTTWKLVEVFLNPTTRKKIHFLGSGFKKELVKHIDPVHLPKWLGGSCECFPAKPHGGCISCPENTQTKACIAMDEYLQARKLAAALPAAPLAEPAAVAPLPPALCVQPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X1T3</accession>
    <name>A0A6G0X1T3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_009388</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000119">
        <property type="protein sequence ID" value="KAF0733823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X1T3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010144"/>
    <dbReference type="OrthoDB" id="270970at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052981">
        <property type="entry name" value="Ingression_C2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47052">
        <property type="entry name" value="CONSERVED SERINE PROLINE-RICH PROTEIN (AFU_ORTHOLOGUE AFUA_2G01790)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47052:SF3">
        <property type="entry name" value="INGRESSION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0733823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="238" mass="26050" checksum="212B297C25E0B0A9" modified="2020-08-12" version="1">MHELQVTVKRATNLRDVQLIGKQDPYCIVQVGARSFRSRVHDNGGKNPVWNDTFVFPVMDPQTEQLVVIIKDSNWVSDEFIGTCLVPVNAFLHGQMVDQWYPVSHGRRQKGTINMSIQLQNASTAGYPGYPQPYPSHQPSFSAQPGYPAYSAHPAPYPQPTFAAQPGYPGYYGGPPIPPPPPAFTAQPGYPAYSHSTPSAPPPPYPGPPPPYPGYQAPFQPTYPGSQPGYPGYQSSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X2N0</accession>
    <name>A0A6G0X2N0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_009226</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000118">
        <property type="protein sequence ID" value="KAF0734055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X2N0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011221"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0734055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="154" mass="17701" checksum="390660ADF33E08D4" modified="2020-08-12" version="1">MDGTLKMSAHQKKPPAFKRMPREEEGSNPPGKINEYDLKAIEDRLLQLEGRVRRDHEAREKYKRAALTKTPSLYELEHEAAQGNVSDERNGSRTQGLQNEGSTDDLTSARRLPGRKSADWFTNAVLAVIVITAILFALQKYRKKHRMRRYHSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X377</accession>
    <name>A0A6G0X377_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycine zipper domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_009121</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000117">
        <property type="protein sequence ID" value="KAF0734260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X377"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002208"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026208734" description="Glycine zipper domain-containing protein" evidence="2">
        <location>
            <begin position="33"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0734260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="26091" checksum="C3249770CDD66788" modified="2020-08-12" version="1">MPSKHFTFDSISMPSFPLVTWLLLAWLSLVFGRDLALSDPRLDNLETASHALAPLVESQDHLRLETTAHRLRARFRGAVARPPPLHGGKVSSSSVGNPVKQLRVRINAKNVGERVGHHIGSKVGGKIGAIGGAKVGGAIGCKVAGPAGCAIGGKLGYIGGKFVGSKVGGLVGKKIGGDVAPHVERLGKESGSKRSPSREKSRQESCKWSQERREEDPKWLQTTLQESLSFENISLLSGAAAVDLVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X3Q0</accession>
    <name>A0A6G0X3Q0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_008902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000114">
        <property type="protein sequence ID" value="KAF0734442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X3Q0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011026"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF317">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="476"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0734442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="524" mass="57180" checksum="5B9498650EE70A22" modified="2020-08-12" version="1">MGLGDCLARHWTSTPPVKTEAQIEAEQYLFCMPWFGGRYLSWKAIKFNRWFLFVASFLCQFCCGSLYSWSIYNVPIDTYIYGEKLGKTAEKAVYAFYIACGLLGSTAALLGPWLERNGPRSGLFLGSTCFIVGYIIAAISIQQKAITGIYIGYGLFVGFGLGINYISPVSALQKWFPDMRGVAAGFAVGGFGAGSIVWGKVYLPARDAFGLPGSFIFLGCIMVFVMYSAALVMRTPPPGFTVGGLNVHGVAEESKEDAIEANFQAINDDDKAPAISAQEGLKNVQNMRMIDCLLSVDFGFMYFMLGGNIVFGLVVLSRLSPMATGIFGQTAAEGANVVSINGAFNCCGRLFVPMISDLLIRFFKFNPPFARKCIYAFTLFCQLVILLTMPSVMRNKNYDIFRFQIWLLTLCYGGGFGTIPAFLTDMFGAYNIGALHGFILTAWSIAGVGGGLGFNFHYKHLISIGTPIVEAYILNIHWIVITVIVGCVALFGVRTNPADRFAPGYQYSICGKPVIKIGANKANN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X448</accession>
    <name>A0A6G0X448_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein O-GlcNAc transferase</fullName>
            <ecNumber evidence="3">2.4.1.255</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_008667</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.255" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000107">
        <property type="protein sequence ID" value="KAF0734709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X448"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019010"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097363">
        <property type="term" value="F:protein O-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037919">
        <property type="entry name" value="OGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029489">
        <property type="entry name" value="OGT/SEC/SPY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44366">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44366:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13844">
        <property type="entry name" value="Glyco_transf_41"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 8" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="65"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="99"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="O-GlcNAc transferase C-terminal" evidence="9">
        <location>
            <begin position="322"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="O-GlcNAc transferase C-terminal" evidence="9">
        <location>
            <begin position="534"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0734709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="741" mass="83576" checksum="1E9B95FBE1205243" modified="2020-08-12" version="1">MPVNLSSMMLWRWTVIFILLAPIELATTAFIAGYFKHAMDVMHAGNVSTAKQLLTRLQLINPDFTDAKIALGAIYQMEGAADKAMQCYRAVLDLEPTNDAAHGNLGVLYFTARDFSRALDHFTTAMTVQPQKVHEFAHMVALAYHDQVNEELAIHYYEKALERKDKDAQIHFDFAVSLQDSGAIMRANAEYNRAIKLRPDFPEAWLNVATLHLRYGDVSMAITNLKRTLECPSITPQLMLQTTINYGVALESDGQAEAALERFTLAASLARLMTVEKNALQEHALRVRRSIALWQDFELLHDVFIHDTVLHELGAGVASSMVPFTSLLVSMSPQIKRRLAEVHTANLYAPSTAKVPNRPRGSRLHVGYLSFDFNNHPTAHLIEGLFRHHNTSAYEVSALSYGKDDGSPYRQAIPSLVEHFVDLILLSNHEAANAIEAAHVDILIDAQGHTLGQRHAIVAARPAPIIINYLVYPGTLGASYVDYLITDAYATPPEHADHYTEKLIMLPNSYQVNYIEMDYKHAPPWSSKAQSRPFIFANYNKIEKLEPRVFGVWMSILRRAPHSELWLMRPSARSNASFDLIVQNIQAEAAQWGISPSRLRFLPRVSKREHLLRQHEADLFLDTFVYGAHSTATDAIAGNLPVLTLAGDTFASRVGISLLTSCNLKSLIVYSAKEFEDIAVFLATKPWILRRFYNHLRHHVRDEPLFNTAAYTHDIEVAYSMAYDLSRHERRIKYHLVLPHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X4Y5</accession>
    <name>A0A6G0X4Y5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_008570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000103">
        <property type="protein sequence ID" value="KAF0734908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X4Y5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020320"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="56"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0734908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="410" mass="45638" checksum="8F62ACB8AB4D4164" modified="2020-08-12" version="1">MLPSTSDARRRIRSLEKLPTKSLLCLGKTQRPSTTTSLRHGQSNADAADRRQLPGYTKLKKLGVGGCGTVWQVQAVETSARFALKQIPKHASGLVSGFVEVKVGLRLFPQADVVRVKLLERSSAAATQPSGDNNRPPHIIQLYKVVETKQDLWLLFEQGGETLHNALFDIKGEFHQGSRSYKITHRPLYLAMRDNVSLLKDLLRQLVQAVATLSAVGIVHADIKPDNILIGQAARADHSLQLMVKLIDFGSAFSASSPRLSSARTPEYVPPDILELVRTKHEPCDVKAYFASHCLPHSFDMWSVGCVFLEIVCGVPLWFSYKSRVTGWDPNRSVTGLLSASGRDPDKIAHRQLHVVEHLTKCIRDSPGMNVDSKRWLYGVDLLERMLSINPSQRIAPDEALRHPFLHQSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X599</accession>
    <name>A0A6G0X599_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OTU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_008496</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000102">
        <property type="protein sequence ID" value="KAF0735025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X599"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000052"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22748">
        <property type="entry name" value="OTU_OTUD6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF10">
        <property type="entry name" value="DEUBIQUITINASE OTUD6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="2">
        <location>
            <begin position="137"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0735025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="291" mass="33747" checksum="3F1D331632972B72" modified="2020-08-12" version="1">METVGQAKQRHKLELRAWQSSQKALVKKWKSENMSKKEIESKLVEMENEIKVRHDTELDNISKQTASTDEPEIKLAEVIVEKATSTAKLDKAQRKRDKKKQEEKARQERIANESRDIVSKRQIECDQIADKLKALNMAIKEVPSDGHCMYHAIADQLKRMDFLPHMSMESHVYLRLRTAKYLRSHANDFLPFVELNYESDVSNEDQFEEYCKRVEESSDWGGQIELRALAQALELPIEVHSATTDVIKMGEEFSKIGEAPLRLSYHLHYYSLGEHYNSVVPLTLDTDEVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X5D5</accession>
    <name>A0A6G0X5D5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_008287</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000101">
        <property type="protein sequence ID" value="KAF0735073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X5D5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015529"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38019">
        <property type="entry name" value="KDA ANTIGEN P200, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38019:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="533"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="191"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="309"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="560"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0735073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="624" mass="73418" checksum="DBDF996DB886D7B9" modified="2020-08-12" version="1">MSPDEASPQENASPAQSMIESPPKAKKKKKRPKLRPQTIEEVFSTLSTVKANGINPPPEKIVLTPRSAEACLRTGVNPETLKIRDLDSFGDNGVSPAVQKMRHEAYSMRRHEQMKLVRAEKKKILSDEDGAAEENTKRSPSNSPKKSNSPEKDQAASMIDMEQRRLEKVQFRQQREIEQMLEFEMKMNRLAEEAAAKLMREKAMHDQMEAEKAQRLKELAEIKRIRELQKKAQEDAAEERRRQVAAQMFQKDKELADQKARQERLRKIEAKMRDEERRKKAEEHRLKTEAIVAKQQEEIQARLMELTLAEETRNRMLEEQREQRAAEMEERREIVTKRIHKNLKQARRVELQRKREIRHKQRQSEMLRAQMKQEQEQQRELAHQEMELLERKRQMVLEEARREEERKKNTLLQKQREIEENVQHLQDAHHRELQLRREQRIIQKQLKLSNVDRIKRIQEYKRLETLRKIREAEERTESMLQQKVDLIRQRKAASVKSKIQRDAIVETMEHVKITKKWKKASKKIDEVLGTKTIKKKRPASSDGASASLHEELPSLRARTPQESSSSGFYQSSPPPIKSAFKHVKEEKKVAVEPSPFRSPYDEIPSLIQKRNSLKSSKHTSSAVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X5Q8</accession>
    <name>A0A6G0X5Q8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_008195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000100">
        <property type="protein sequence ID" value="KAF0735280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X5Q8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003206"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052050">
        <property type="entry name" value="SecEffector_AnkRepeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586:SF3">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0735280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="443" mass="49646" checksum="CF1D3447DAAB6587" modified="2020-08-12" version="1">MTAEAATRVFHAPELLQTIWSFQNGTHQDLLPFYALSNPSLNHRVPDFTLPFHQFEENDRVLAPWYATYNLTRLDRLFEHIQHAKPIVLSHAAFFGLKHVIEAIAASKYLPAVMAVDSLVDIAAARGDTDLLDFLRQYHRGYTKHTLRLAAYYGQRYVLERFLPYSNLFSAQVMDSAAAGGQLELIQWFHETQMSGFTASVMDKAASNGHLHVVQWLHTHRDELCSIRSVAGAASNGNEHVVRYLFDHQLVSTCPTYGVDLAAGNGHLNVVKYFTEVRPLKCTRLAMDLAARNGHLPVVRYLHEHRSEGCTVVAIDKAAAHGHADIVAFLTEHRKEGGTRRAMDRAAASGWLEVVKYLHEHRREGCTTSAMTMAALNGHLAVVQWLGENRREGCVTWTLTFAKDPAVVACLRTLPPELIHEFHGLGLGRLLDEDDEEDDLSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X5S2</accession>
    <name>A0A6G0X5S2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF445 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_008246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000100">
        <property type="protein sequence ID" value="KAF0735335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X5S2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013918"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38568:SF2">
        <property type="entry name" value="DUF445 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38568">
        <property type="entry name" value="DUF445 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0735335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="30469" checksum="28C0FC97D77D72A3" modified="2020-08-12" version="1">MLSPAKAERFLFHTTSSASAALPTYRGRPTIGDFTNGCCALITLAGIVLILVNELQIGRPVTVVGSCGLVAGLLNALFIHLLFHPGRLGCLGAGVFEREACSVAIQLQRQMVHAFFSPHQLAASATAASFRSVQDLVQVFLHDDEHDSHQILVNALTHVASTPNGAVLNSFAGLFGGIEPMVPKVKPLLIALAAEWDQQNNGAEARLQWIFGMSSHDELLQRLSQEINNMVHTRVMRLEPPEVSAMVESLVRHHLAWIVVWGNVCGLCLGGLLVLLLSYSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X6H6</accession>
    <name>A0A6G0X6H6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_007917</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PTH2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="VJMJ01000094">
        <property type="protein sequence ID" value="KAF0735597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X6H6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006392"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008517"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021343"/>
    <dbReference type="OrthoDB" id="1733656at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02430">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1490.10:FF:000001">
        <property type="entry name" value="Peptidyl-tRNA hydrolase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="entry name" value="Bit1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00283">
        <property type="entry name" value="arch_pth2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003314">
        <property type="entry name" value="PRK04322.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649:SF11">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="Peptidyl-tRNA hydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026263388" description="peptidyl-tRNA hydrolase" evidence="6">
        <location>
            <begin position="25"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="27"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0735597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="178" mass="19093" checksum="F686B81E2E7D9D1C" modified="2020-08-12" version="1">MEVAKGTAAFFLGVLVASFLPTTALPSLTSSRKTSHQKEDAEDASDEDSDDEEAGEETLKWEPHKMVLVVRNDLKMGKGKIAAQCGHATLGAYKRAVKRTPQALECWEALGQAKVALKVETEQEMLELAARAKELGLVHYVVVDAGRTQIAPDTKTVLAVGPAPNGDVDALTGHLKLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X6N2</accession>
    <name>A0A6G0X6N2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_007982</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000094">
        <property type="protein sequence ID" value="KAF0735666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X6N2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018082"/>
    <dbReference type="OrthoDB" id="69639at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0735666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="114" mass="11914" checksum="8DE6B2060B966398" modified="2020-08-12" version="1">MVVTFSTATEYTFRVGYSFSTVTSDAVPGIGLFGKAVAITTSPVSDSAGSVSKYTRPDRIAMLQKAGLSPTEIINLSKDQATIQVSRRSCIQSYLNDYPGGTSLLGTSSASSCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X6Z3</accession>
    <name>A0A6G0X6Z3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(+) ADP-ribosyltransferase</fullName>
            <ecNumber evidence="1">2.4.2.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_007738</name>
        <name evidence="10" type="ORF">Ae201684_007742</name>
        <name evidence="8" type="ORF">Ae201684_019188</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>NAD(+) + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H(+).</text>
            <dbReference type="EC" id="2.4.2.30"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.30" evidence="1"/>
    <dbReference type="EMBL" id="VJMJ01000465">
        <property type="protein sequence ID" value="KAF0721277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VJMJ01000093">
        <property type="protein sequence ID" value="KAF0735730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VJMJ01000093">
        <property type="protein sequence ID" value="KAF0735734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X6Z3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004415"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990404">
        <property type="term" value="F:NAD+-protein mono-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070212">
        <property type="term" value="P:protein poly-ADP-ribosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07997">
        <property type="entry name" value="WGR_PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050800">
        <property type="entry name" value="ARTD/PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036930">
        <property type="entry name" value="WGR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008893">
        <property type="entry name" value="WGR_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004170">
        <property type="entry name" value="WWE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037197">
        <property type="entry name" value="WWE_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10459">
        <property type="entry name" value="DNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10459:SF60">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05406">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02825">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00773">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142921">
        <property type="entry name" value="WGR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117839">
        <property type="entry name" value="WWE domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51977">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50918">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="WGR" evidence="7">
        <location>
            <begin position="75"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="WWE" evidence="6">
        <location>
            <begin position="171"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0721277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0735730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0735734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="259" mass="29208" checksum="0F3EC81810AA075A" modified="2020-08-12" version="1">MAITRSTTLKKLNVEAPSSVQGQEILNKAINPEDIHLAQDITKNKAKSVASLPPLDPETSSHVDPAAESRLSNLKCSLAHDGDGVPLNASLAFIDLANNVDEFFLLQVIKAGRYYFVFTKWGPTGTNGQTKLQGHLNFLNAFRSFHNTFLEKTGDMWANRSSFIKIDGKYDLLRPTSPTQESGSWKYYMDDFVDGKATGWHPYTVEGTAQTELLHQTHQTNSAYNRRIVQSGHFKYCIDLDEMTQTNIKTNKRRQIRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X8J4</accession>
    <name>A0A6G0X8J4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_007227</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X8J4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002447"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="11"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0736204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="138" mass="15188" checksum="092EE90DEE855789" modified="2020-08-12" version="1">MLVARQSKRLVPRLVGLRSFTSFEKDENGMVNINSKVAFDAIVASGKPIVADFWAPWCGKCTQLSGFVENLAEDHPNVTFVRLNTADEGVTPIKVALNVQVLPTFRFFHDGKEVGSPVTGYKKDQLGHEVAKLDTLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X9P0</accession>
    <name>A0A6G0X9P0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_006951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000087">
        <property type="protein sequence ID" value="KAF0736792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X9P0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021786"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021787"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF317">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0736792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="403" mass="44867" checksum="3E4CE609EEBCC67D" modified="2020-08-12" version="1">MWSRQPQQERPPSYWSVVPQEKTTAEIEAERWAFVVPYAPGKYCLPLCTVQFRRWMLFLAAFVVQFCNGSLFAWSVLNQPIDNFIQGKARDSVPPAKEMAVVTFYITAGVHGCATALFGPFVERHGPRHSLIVASSLFFVGHVVSFVSVYFKSYVGLYIGYGVFCGAGFGIAYIAPVSALLKWFPDLRGTAGGFAVCGVGLGTAFWGRIYPFLIESLGTECFFLVFGLLLCLILLISSCILRTPPPNYVVGGRNVQGVKVTERRTQSVVSKQDDSTEERVSVVLGEVQRNNFFNVFDYQELELGEAEILYHNKIKSLRIRECVFSVDFVLLYLVFVGASVAGTNVMSRVYNIAASVYSHVEDDDLIQMVATMSIANFFGQVLCPLISDKYITLAQLTQRLAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X9Q2</accession>
    <name>A0A6G0X9Q2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_006974</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000087">
        <property type="protein sequence ID" value="KAF0736817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X9Q2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001414"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05276">
        <property type="entry name" value="p53_inducible_oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014189">
        <property type="entry name" value="Quinone_OxRdtase_PIG3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02824">
        <property type="entry name" value="quinone_pig3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF8">
        <property type="entry name" value="OS02G0805600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="10"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0736817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="330" mass="35033" checksum="4397DF2A5E737B41" modified="2020-08-12" version="1">MQAIHISTPGDANVLQITTRDIPTPGEGQVLIKVYAAGLNRLDILQRRGAYPPPPGASDLPGLDVAGEIVALGANATEIAGFRVGDKVCALLSGGGYAQYAVATASHCLPVPTGWSYVEAASLPETYFTVWSNVFQRAHLSSGETLLIQGGSSGIGITAIQLAKAFGHRVFVTAGSAEKCRECEAFGADRAINYREEDFVSIVKEATNGAGVDVILDMVGGDYIPREIDALANDGRIVMIGLQRGASAQVDLGQILRRRLVITGSTLRAREVPFKATIAAELKARVWPLLEAKKLKPSVYKTFPLAQASAAHELMESSTHVGKIMLDISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XBA0</accession>
    <name>A0A6G0XBA0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_006556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XBA0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021757"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0737391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="359" mass="42112" checksum="A9069549F135DA82" modified="2020-08-12" version="1">MEIADEKRERKLVYNRNLLREKRRQYLSERQALTDELNMLSKKLRVKLDKALLPWRDVVEGLQDDYEIQQNVTLALRTKTRKNSQVIEALSKWVNDIFAPKIGQSLQLPSETWRNVTLPKNPDIRRVGMDWITQQLYQNTDNVFYRHELPPTSNLNDFFIDYDESLSYVWRYQHDFEMPFEPFCDILRDTVGEFVKGGMWGSRFSSYLDDNVLPGITYARSIRSPEEAVNYLSRGFISADRAVFVGRNVLADEILPTSQRQSQRMFWYALEKLSPTQTRCRILILKSQDFTKDGYVSIDEEASYWGCDLSQCPEKLKLQTFRAHIAHVGRSLLARGTFHMEMRMLQHAMSDKSDASSHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XDF3</accession>
    <name>A0A6G0XDF3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_006171</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0738195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XDF3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011742"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0738195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="89" mass="10539" checksum="CF1D4204BFCB21D0" modified="2020-08-12" version="1">MAVQPFRHKGLAKDQYREELREIKAILKELGQQHQRKWFQKRIEPPVPTVDAYLTTKVKVSGVRIPFSSKMARQYKTRIYRLPTIQESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XDQ8</accession>
    <name>A0A6G0XDQ8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sperm-associated antigen 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_005875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000077">
        <property type="protein sequence ID" value="KAF0738318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XDQ8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001168"/>
    <dbReference type="OrthoDB" id="7537227at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000196">
        <property type="entry name" value="Sperm associated antigen 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23314:SF0">
        <property type="entry name" value="SPERM-ASSOCIATED ANTIGEN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23314">
        <property type="entry name" value="SPERM-ASSOCIATED ANTIGEN 6 ARMADILLO REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0738318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="509" mass="55343" checksum="48E47E2587BBA83C" modified="2020-08-12" version="1">MASTSVLQHFETYQKARVTFVQAVAEAATRPQNIEVMQNAGVMQLLRPLLLDNVPSIQQSAALALGRLANYSDDLAEAIVGNEILPQLVYSLSEQNRFYKKAAAFVLRAVAKHSPELAQAVVDSGALEALVPCLEEFDPTVKEAAAWAIGYIAQHTSELAQSVVDAGAVPLLVLCIQEPEITLKRVAASALSDIAKHSPELAQAILDPGAVAYLAPLVQHPDAKLKRQVCSCLAQIAKHSVDLAEVVVEAEIFPNILHNLNDIDHTVRKNAATCIREIAKHTPELAKLIVNAGGASTLVDYVAEASGNNKLPGIMAIGYISAFSETLALAIITTKGITPVKNALVSEPEDHIKAASAWTLGQIGRHTPDHARAIAEADVLRHLLACMIHPNSSDDLKTKAKRALKSILAKCTHLQALQPLLRDAPMKVQKYILKQFAQMLPHDLEARRSFVQNGGLQFLQELSEAAGGKLTEYILEINNCYPPEIVEYYSPNYSKTLLDKLDEYQPQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XDT7</accession>
    <name>A0A6G0XDT7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PLAC8 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_006192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0738217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XDT7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005859"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006461">
        <property type="entry name" value="PLAC_motif_containing"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01571">
        <property type="entry name" value="A_thal_Cys_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15907">
        <property type="entry name" value="DUF614 FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04749">
        <property type="entry name" value="PLAC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0738217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="21917" checksum="2C5CBD68C4BAE7B5" modified="2020-08-12" version="1">MSKPQPQVETAVPVAVPYVVFEVATPQADPNGILEGQWKAGICDCCSDLVPNCCMAYWCPCVSLGQTMARVEASGTTYMVIYGLLYLVYLGMSFSSAAEGNGWFSRNDYYNRYNYHESHFTWKSYVQCTAFVISTIVLMAARSSVRSRFNIAGDGCTDCICSCCCSCCVIAQMATHVEAYTPGQCDFGFKDTLPAYQPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XEE4</accession>
    <name>A0A6G0XEE4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_005535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000071">
        <property type="protein sequence ID" value="KAF0738607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XEE4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018871"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF467">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="314"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0738607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="346" mass="38412" checksum="79F4DA3846E4EA02" modified="2020-08-12" version="1">MADLKSAIKQRFASKDMGPIHYILGLKIIRDRKKRLIHISQPLNALNMLKQFQLDRARPATIPLNEVLKASDSPTEDQTKSEAYAAMHASYRQGVGSLMYLMLGTRPDLAYAVQSLSRFLNRPGKKHFGEMKRIMRYVAGTMNYGLLYRGSDLDLCGYTDPDYAANPDNRRSVSGYCTFVGKCLVSWASQTQRIVAQSTTEAEYIALAQAAKDVLFMKTLNCELGNPIKTGSIIRVDNQPAMATACNPVNHSRTKHIDVRYHFVRERIQLEELKLEYVPSRDNVADLFTKPLVTAVFVPLREKLGLGLPPVSPSTPTTTTNSAHPSAHQCNSACTSAPATLRVPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XEG6</accession>
    <name>A0A6G0XEG6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_005609</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000072">
        <property type="protein sequence ID" value="KAF0738558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XEG6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008293"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="1">
        <location>
            <begin position="40"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0738558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="381" mass="42132" checksum="A8C19A2D079C4E0C" modified="2020-08-12" version="1">MNARWINETPLRQLTIHFEFPVHNQQHQQRNGPQQPPHAQVGSLQLNNRVIMPPLTRIRAGPSHLPNDLMKEYYAQRASAGLIIAESAMIEPNLSCSYGEPGVYTDEQLAKWKEITDAVHAKGGKIFVQIYHGGRAAHPFFNNGAECVGPSPIAIVNEEVHTPAGKKKHVMPRELTVNEISAIVQQFATVAKKCVEVAGFDGIEVQASGGFLIDSFLKTSANQRTDQYGGGSLENRTRLLAEVFQAVTEAVGADKVGVKYSILGGYNDMYEENPLELSEQVAKVSQRFNLAYVHLARKDMWLASNWTAWRRPSDEANDVIASGLADAVSFGSLFIANPDLPERFAKDAPLNPVDPSTFYLGEAKGYTDHPTQSAWSIHWKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XG39</accession>
    <name>A0A6G0XG39_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Centrosomal protein of 19 kDa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_005246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000067">
        <property type="protein sequence ID" value="KAF0739065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XG39"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013354"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0739065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="31467" checksum="53FE9AF38C62F110" modified="2020-08-12" version="1">MAAEVLPKRLGLKYAPVPTVALEYEDVDHSLKLAVVELPDLERHAAPKDVVAKVQKQNELFRPTVVNESQLIRLLQQLIQQQREPAETLNLSMDVPKDEIEADRPDSRPNTPQKEELKDADDQMENEESKPVETEPPQEKNQSKDEEKPVQSSKEVVSEEAQVHESDFDESFEEESFIEESADKDTNKQNSFVTQPTRGVSSAGDDESETPRGKFGSGTTVRQDDDTSPSSSLPSNISTVSATDTKPAVEQAPVVKETPSIKKADESVDEIPSDDEELGTNDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XGG0</accession>
    <name>A0A6G0XGG0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_005074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000065">
        <property type="protein sequence ID" value="KAF0739298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XGG0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017315"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0739298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="254" mass="27213" checksum="2AA515B6AE36BCB5" modified="2020-08-12" version="1">MTTTPSETNNTLVLSPPQAVSHDSTRSCASILFSTVGTDLEEERELMQQVDACLTSLDVTQEETTASTPTITVAVVAFEWATTYQRTTVEGHGKPSCNLANEATPPEEGHVVDIVSSTAARIDPNANCSPNFDTHDLPRAISSPYSGDDVSSNADTALGSQVETSNRPKCSLNDVGTTESVDKSPHCPEPTKNNSVTTTANSTLGSSSSQRQHIGRHNTSYRRELDTYGWPSMSHAEIKMDLLVGCPLGYLPPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XGM8</accession>
    <name>A0A6G0XGM8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CSN8/PSMD8/EIF3K domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_005049</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000065">
        <property type="protein sequence ID" value="KAF0739272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XGM8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003731"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010387">
        <property type="term" value="P:COP9 signalosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033205">
        <property type="entry name" value="COP9_CSN8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13339">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13339:SF0">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="CSN8/PSMD8/EIF3K" evidence="6">
        <location>
            <begin position="56"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0739272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="220" mass="24354" checksum="DF87D31DF1BEB109" modified="2020-08-12" version="1">MAIPNAQVEKKGLDDKIKQIFHEHQGGQALDVRQLVLLCEELELVSWSSGPNAMDAAYYALFLAGLLTLRELNRAKHLWRRLPEKDKNGLPEIWAVGQALWKREVSQAYVAIAAAEALPLNVEIKAVLGELKKSIGLYNASLLGRAYASVPTAVVAQALGLSLDDTLKFCASRQWRVQGDLVFPTKEVSANGPSTEAELEQLRQLSSYILHLEQRSVLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XH34</accession>
    <name>A0A6G0XH34_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_004799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000063">
        <property type="protein sequence ID" value="KAF0739625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XH34"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0739625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="87" mass="10250" checksum="BEF09B2E341A4CCC" modified="2020-08-12" version="1">MDERKKISHVHCHCYRRRRLSVHWNLLLVRRQDLHSPTPTICLPHKALHRIDSFDKGKQSEQGITERNHKASNASAQRIEETTRCDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XHU6</accession>
    <name>A0A6G0XHU6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_004687</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000062">
        <property type="protein sequence ID" value="KAF0739801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XHU6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005129"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="82"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0739801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="423" mass="49335" checksum="5F80A31A53F9F552" modified="2020-08-12" version="1">MGPPAPSKLRQPTQYASPPRQPKFSRSISNTSDDTSDSDSCVFPRQLMQLHKTAKKRNLARSKARAESTDDEDTFHMISDRLPSVERELKAKTERMLDLEEMLAAERATNATLRAQLQAAEETNRDQLDKLTHTTLENEQLRRDMTRLQDEYRRNMIDREDAWTKQQDRLRQLQQAYRDVESQLDDCFAALHAWKEQAKQADSSTRCMWQERLEMEYNLVRETAQSNQTKEREARMDELKVLQKIRAVSQSVFVDETTPETPQCRRRSLACLDDSLDKIDMKDPLAWIDTWAERQIQRHQDSLAWLNDLDQRMHEDSRRFVAALTAEDASSFVWRIEDEDDTLREIDVLLRRHCSSDVKCTNASNRLDRHETSKAGNRRGFDTMGVYSPSATSRFQRRPEMIAQPARRRRPHCALCGVGANWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJ04</accession>
    <name>A0A6G0XJ04_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_004269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000053">
        <property type="protein sequence ID" value="KAF0740268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJ04"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0740268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="274" mass="30112" checksum="FB058ADB391E62E1" modified="2020-08-12" version="1">MSQRETCSSKRKTRSQSVAAAPTPPPRKVPRKPNTKKKQKPRKQTISPPSSAQATLPSSSSNRDASKANAKKKQKPRKQTVSPPSSAQAASNRDASKSNAKKKQRSKKQAISPPPSVPITIMVYPPSSPSSRDASKLKANCLLDYHGVQDAKVVQSHQGQLLKTSFPVDNKTFELAVVQVHDEFYFFTTMHRTNGFPEFSLDGPCTLLEAEDAFIKMLLRKANTEWPPSSPSAVASSASRSHQATRQLRQGFFVPQPTGPPHILNGRAVEFRMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XKD9</accession>
    <name>A0A6G0XKD9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_003854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000044">
        <property type="protein sequence ID" value="KAF0740788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XKD9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012601"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24002">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24002:SF3">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0740788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="26929" checksum="F54118A187E42A6B" modified="2020-08-12" version="1">MHAMHAAQAAMAVLASEDMRATAMGRLSLSYGVGMVLGSYAGGAISAATSNQTSAIVAALLSFSVLPINWFTLRSDAPSSKSNQAIEKAPSSIDLYKICTFSEVLRQVIGLGPKDIGLVMSVGGVVSIVANGVLLQFFLSRWSERSVIFGSSVVIALSFVLYAHLPIGEGALAVLMALTVPLMGASAIANTVLSSQMSKGAKNEDRATAIGLSHASRSACGLVAPTLGAIVLQDYGFQALGYTCAIATVISIACSTKPRPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XKJ7</accession>
    <name>A0A6G0XKJ7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDENN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_003885</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000045">
        <property type="protein sequence ID" value="KAF0740754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XKJ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012780"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051942">
        <property type="entry name" value="DENN_domain_containing_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005113">
        <property type="entry name" value="uDENN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15288">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15288:SF0">
        <property type="entry name" value="UDENN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03456">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00800">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="3">
        <location>
            <begin position="221"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="545"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0740754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="874" mass="97010" checksum="58BA25D879FC17E6" modified="2020-08-12" version="1">MSQTTPCDCASKWQARWEEAVKAKEYALYEANEWKRKFLAEQDRRRELSKALLYFVKQDKQQTTPANTEAMIKKVTAMLSDTSDTTALLTPTLPSFDLDYDDDDESADEESGSFVAKPKGKQPFRRPVNLNLDNAVYESRPARSNTIDAGRSVHSPRSHKDFDYPHLLLRPFLTDKSLWHVSPHSRRLHDLVQGMTFFQTKRDRIFEHFLVAGLLSSTGLEPAASATVHEDDAALASWKPKVLFQYPPSSVYPLNEQAVSSFCFPVGVPAFSCSAKDAARLKGCLVSQWMPDASSTIRQLLDPLHAQTYTFRLTGSKGEALYGFCAAVLMDIEEPAILLEKGSDDAATADSAADVRPATPAGKPSNSKFHSLAGILASPQTGATLDKDAFKSTITPRCYCFTSKYPLYKLHFQLLRLVLETDLKTRQQARHCHSVHTHEFEVTMVDAALGISFHEREDIGHYAQPRDRDHQVKLLNAIASPPPPSPSNSIVVTENTSADEISKPPTPATRHVRSRSWGGGADRSPVKRASLGKAPLTCAIVHTLTAAAAEAGIASGDILTAINGFPVDDMGFPDIMHLLETSKRPIHLRFKRLFHKNSTPVEPTTGPMYGSAVLDLLRRFRSMKVSEPGAWSTVKLPHADLKYQFPTGRTDDWTVGVLLRVMDAASIVQVLSCLLLEKQVAIVSESTAKLSVVNTALLALLRPFQWQSTFIPVLPSNLLDFLHSPVPFLVGVHPPLSTDEWPDVCFADLDAGTVECAQILAFPRMLELTRVLKDHSVQFAQVPSRPGQPWYEVTEHESQLLTQILSRSESILASMCSDVTKLSLSPQADKTAYDVLQEEFVKTIELSEHPAFMTEFAQTQLFCQYCELVLDFVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XLD3</accession>
    <name>A0A6G0XLD3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">mannose-6-phosphate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_003726</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-mannose 6-phosphate = D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12356"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="5.3.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mannose-6-phosphate isomerase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.8" evidence="4"/>
    <dbReference type="EMBL" id="VJMJ01000041">
        <property type="protein sequence ID" value="KAF0741163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XLD3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004231"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00423"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07011">
        <property type="entry name" value="cupin_PMI_type_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000044">
        <property type="entry name" value="Mannose-6-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.441.10">
        <property type="entry name" value="Phosphomannose Isomerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001250">
        <property type="entry name" value="Man6P_Isoase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016305">
        <property type="entry name" value="Mannose-6-P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018050">
        <property type="entry name" value="Pmannose_isomerase-type1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046457">
        <property type="entry name" value="PMI_typeI_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046458">
        <property type="entry name" value="PMI_typeI_hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00218">
        <property type="entry name" value="manA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309:SF0">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20511">
        <property type="entry name" value="PMI_typeI_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20512">
        <property type="entry name" value="PMI_typeI_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001480">
        <property type="entry name" value="Mannose-6-phosphate_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00714">
        <property type="entry name" value="MAN6PISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00965">
        <property type="entry name" value="PMI_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00966">
        <property type="entry name" value="PMI_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phosphomannose isomerase type I catalytic" evidence="10">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphomannose isomerase type I helical insertion" evidence="11">
        <location>
            <begin position="173"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001480-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001480-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0741163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="396" mass="44095" checksum="462432F0A2B44971" modified="2020-08-12" version="1">MQPLDCVVQQYAWGKKGTDSVVANLKAASDKTFQVKENEPYAELWMGTHPNGPSSLASTSQLLSEFIKENPRVLGTAGEEIPYLFKVLSVNQALSIQAHPDKTAAKRLHRDFPHIYKDDNHKPEMAIAITRFEALCQFRPMEQIVDNIKQVDELRLLIDPAVTEAVVERRDLPSLRAFFRAMIYSNPEKAVTALESLRSRLEAQRESLTALDSLVLRLNEQYPNDIGAFSPYILNYVVLEPGDAVFLGANEPHAYISGECIECMACSDNVVRAGLTPKFIDKDTLCDMLTYKVGSPPVERGKVVDDFLTRYSPPVPEFLVDRLKLPPSTPYSLPAVSGPSILVVLSGHGFASVHDDQNELSPGRVYFVPANQSIHVKCSQDHLELYRASPNEEANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XM34</accession>
    <name>A0A6G0XM34_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TFIIS N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_003535</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000038">
        <property type="protein sequence ID" value="KAF0741246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XM34"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="3">
        <location>
            <begin position="38"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0741246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="131" mass="15504" checksum="4CE08589E8A3ED1F" modified="2020-08-12" version="1">MDRFLTRTAGPTQAGVEGQSKSNSRMRQTRIEHGYKVEIVEEIIQLAQVMDQSEEKELPLLLQELDKRFISLELLEQTDIGKALVRLYRRTTSDEVRERAKQMLRKWKRTALDGLRRRHKRVETFGRNMAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XM78</accession>
    <name>A0A6G0XM78_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1279 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_003500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000037">
        <property type="protein sequence ID" value="KAF0741393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XM78"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004135"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0741393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="177" mass="19637" checksum="1970C666D17CEF2B" modified="2020-08-12" version="1">MLSSVRHITTRSSKYSKLAFPRLVAGTHVPPTMQFPMMHVHAFSTTSREKELEAENKKLKEEIAALQKKVDKKGFIAMVKENGLPFVLWWVTLYVGGGVGIYAALEAGYVGGGDAIHLLQSLGLDQYYDTKTINPTYGNAAVAIILNEFLEAIRLPLVIATTPMIKRTFQKKAVENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XMS7</accession>
    <name>A0A6G0XMS7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M13 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_003193</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000036">
        <property type="protein sequence ID" value="KAF0741508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XMS7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000404"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF167">
        <property type="entry name" value="FI17812P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0741508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="192" mass="21476" checksum="420B5072E7A76C66" modified="2020-08-12" version="1">MMQPQFFDLQADPAQNFGGAGLVLGHEIFHGFDNFGRNYDSVGNLAPWWSNSSDAAFVKKAQCLVDQYGNFIARSETTGKVIGNLDGQLTLGENIGDNSGLKASFRAYQGYVKTHESKYTKETGEKLFFLSFAQSWCAKNNDAGLQSMLLDPHPPNRFRIFGALQNNFDFARVFNCPTDTFMNPSKKCTLWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XMY1</accession>
    <name>A0A6G0XMY1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_003277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000036">
        <property type="protein sequence ID" value="KAF0741597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XMY1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012619"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026062021" description="Secreted protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0741597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="392" mass="41018" checksum="05FF6E838CC6E1C2" modified="2020-08-12" version="1">MKSLLFLPVVALAVTAQTNSTANTTCTSLYSRKSAMYQALVEFFRSDTVPETTAYILDETLSSLPTSWATCIGSLDPSAISTAVSTAFAGQSTCLAAAPTLLPLFETNSSSTIVSPDDSRSSWSSWLNVSDSYFQQLCSPLVASVLPCIDTAVLAPIFTQINASSCCTDMVNGFQTITGLSPESFFTNLLKLGSDQPTCGYAWIKSFTAGVTSWRNISTLTTRIYTALQVPNDQGCAAAKGSSFTSTTGAIVSNLFTSPTVPGSCAKPADSLLTWVRAFPGLTNASWGDVRILDLLEDGKCVNGTTISKTFGREATEVYAELGLRKKDVDAGCFHLANGGLGSCTFSDATTSAWPSSSSGSSSTTPSSAKSASSPLMLSMALAWAIVAVALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XPG7</accession>
    <name>A0A6G0XPG7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_002658</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000028">
        <property type="protein sequence ID" value="KAF0742384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XPG7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017502"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050940">
        <property type="entry name" value="Actin_reg-Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46485:SF5">
        <property type="entry name" value="CENTER DIVIDER, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46485">
        <property type="entry name" value="LIM DOMAIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="51"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="8">
        <location>
            <begin position="338"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="10">
        <location>
            <begin position="447"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0742384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="513" mass="57174" checksum="2D5FD5BC0787E5FF" modified="2020-08-12" version="1">MREIVAAFVAVGSAATAALRQCCQFGPGETEYELLTMDVLSSPTTLHPSNLTIGRIVGSGAFSTVFKATLENRQVALKCQNAEAHAYRERDLLKQLHHPNLSRFLGSCEYVNSMGTKELWLVTEYMAGGDLSNALTTLSWTQCIQVALDSANALHYLHENHVVHRDIKSSNILLSADNRARICDFGFAREIVRESGNGSRKRSMTLCGTDAYMAPEIYFEEEYDERVDIFSLGVVLIELICRRKVHKRNFLMRTPANHFVIDVEAFRQAVPAGCPSSFVCLAEMCVAANPDDRPSALEIVEWLQDLKRDLDSNPASDVDTVCSEDAFSTYLSFESSAPPQYEGILLMRPSESTSLWREMRISMRDSALTIVDDSTNSQDTLALADCSTIPEAKDRHWLIDGKDCAWECQAKSLVERELWVAFLNHGIQVAMTPRQDIASSIGSENDDASDEVHQWLSSLGLSHYFGDFKAKGFSSLDFLRETGLEEDDFCFLGIESTDDQAKLSHAVSVLREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XQV9</accession>
    <name>A0A6G0XQV9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-reducing end alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="4">3.2.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_002402</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 62 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="4"/>
    <dbReference type="EMBL" id="VJMJ01000025">
        <property type="protein sequence ID" value="KAF0742701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XQV9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017434"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005193">
        <property type="entry name" value="GH62_arabinosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40631:SF2">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40631">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE AXHA-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03664">
        <property type="entry name" value="Glyco_hydro_62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0742701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="147" mass="15929" checksum="9A94F11064273CFD" modified="2020-08-12" version="1">MFVICDSANCYLFSSDDDGHLYRSQTSISNFPNGISQPVIAMQDTSNIYALFEASAVYKAGSQYLLLVEAIGSDGNRYFRSWTANSLGGSWTPLANTEANPFARSNNVVFAGSAWTKSISHANSSVPKQTKRSRSTCASLFVSSTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XT73</accession>
    <name>A0A6G0XT73_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_001750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000013">
        <property type="protein sequence ID" value="KAF0743607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XT73"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005675"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0743607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="29046" checksum="C0D9B76CE6F1F80A" modified="2020-08-12" version="1">MDSNYELIDLYHAYDAALLDRFYVDVLEPCFGVSPDGLESVGVMHRQLAHGNHAPNEAHVLHIAVVKDKTTGVIVAGVSFEYYKRSNCGLVAYLATNPNIDTRRMNLGVYLAAHCADVIIPYEAQRHGYKYCDAAFVESHSDSVEHDTMVPAHRRSILATKIGIRYLAFDYVTPRLESGKQKCRHMYLGVETRFCLRENGKDIGMDSSIVAAFLIDYYNVAMGSEAAACDIDIQRQLKWLAANPVLPLIETTAFQPVARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XTC4</accession>
    <name>A0A6G0XTC4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_001507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XTC4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004260"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033749">
        <property type="term" value="F:histone H4R3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106140">
        <property type="term" value="F:P-TEFb complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02208">
        <property type="entry name" value="cupin_RmlC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050910">
        <property type="entry name" value="JMJD6_ArgDemeth/LysHydrox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480">
        <property type="entry name" value="ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480:SF22">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="1">
        <location>
            <begin position="323"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0743864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="557" mass="63787" checksum="B52C123CE0B4D0DB" modified="2020-08-12" version="1">MEGQSFCKACDLLPGETIEKLNLDLEDQNCNCSARSFEDTPEYLTRLPFDVRHKDPSLPQRHFQLKVFEGDVATLDDKKFNVCSEFDLDGESCSMFAKKYSSKVLQAEVQHSTNLLLKLSPHTLRPLRALLNVIEHLKATVDYEQERYRVAANAVSSLRRDLKQEQYRHEQSKIHCPLNRHNEILHYGAATCLSPSSQNQTKIAEAVKNAPKPIPRFDMRKLKYHEYLELVNKSMPFILTHAKLLAGCPGVPPWSVAELKAACGDRSTVLKSKSDYDNSLWAFKLQLAHLSRHFWMTLPIDRMNHGPTVYQASTCMTLAWQHFVRNSSSRSWLIPKYFAVDALQRVCTKNSAYWPSLFIGNNHTTSGLHVDWGSTAAWMGLLQGQKRWRIAQPSERPFLYERVQDDLEAHPLMQHAHIYEGVLEAGEVIFIPADSPHQVVNLDMTIAVAMNFVDGGNIDAHREFVRYQLMETDNAVVSKHLQRALDSLTEISIPQDVEPISLPFTLFKQLQFNCSRLLLVSKIWKGYASRGVRSCKLSMSVESRWILRFSARHEHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XTP8</accession>
    <name>A0A6G0XTP8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_001560</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XTP8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004456"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
        <property type="entry name" value="FYVE_like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="5">
        <location>
            <begin position="269"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0743918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="437" mass="48884" checksum="E5DD8D91A9C8279A" modified="2020-08-12" version="1">MPLKTPIADEFFACTPLTHEQVHDFRAQGVDAMRDLLACTKLEGGPVDWTLLTNSAKVQIYTTKQDDLPMFLGTIQIESTLDEVRSIFTAPTTDDVRELITAYFPNILDNIRLYNITDPMANIPHHAVTINWLLLSSPLRGIIVKYRDWCYLEHQQDVIIDGKKAWLRAMKHVDIAACPDLEAKYGIIRGQANLAGFIYMETGRPGILQVLELHHDDLRGQIDMSMMGDFMTAKTAEIQYHSMNMMQTNLISHRLSRLDFLSERSTVPKHSRSKCRVCLRKFGTFSRKSNCRRCGEVVCSKACSNVWTLVKGGIRINVRLCSRCSNVPAEVFKSLMKEDDMQGSHFTDSSFSGYTGIYSKTASSYSASTPSLILLESAASGITSHGALAGPVVADMDYRGSAHEMKNIRSSYESEAPFGSYACLDMRILETTNSDCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XUQ1</accession>
    <name>A0A6G0XUQ1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GMP phosphodiesterase delta subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_001326</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PDE6D/unc-119 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000010">
        <property type="protein sequence ID" value="KAF0744188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XUQ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016875"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.40">
        <property type="entry name" value="GMP phosphodiesterase, delta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008015">
        <property type="entry name" value="PDED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037036">
        <property type="entry name" value="PDED_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12976">
        <property type="entry name" value="RETINAL ROD RHODOPSIN-SENSITIVE CGMP 3',5'-CYCLIC PHOSPHODIESTERASE DELTA-SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12976:SF0">
        <property type="entry name" value="RETINAL ROD RHODOPSIN-SENSITIVE CGMP 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05351">
        <property type="entry name" value="GMP_PDE_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="GMP phosphodiesterase delta subunit" evidence="4">
        <location>
            <begin position="108"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0744188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="239" mass="27241" checksum="B24CA93564180D24" modified="2020-08-12" version="1">MERKGYKHTDDDESYEKASEDKDYDGDHDAESKSVTSSGQDDELDALDKMDDLEVEQEWNAIRHLPSGGRIQKATDPRGKCIAEGLKMYAAVVVVVVVLVISLQCDRNFMNMRCGDTGRLLWQSQKWGHDMFEREQKAVVPKSILDCGSVSREINFSSLHEITDFRLEQRVFLHGKCLEEWLFTFGYVIPDSTNSWQQMIEAAETMLPADAISGKITIETGFYDGDALIAKTVYRIFYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XUZ3</accession>
    <name>A0A6G0XUZ3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_000860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XUZ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016819"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="11"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0744374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="189" mass="21416" checksum="965B767927C86269" modified="2020-08-12" version="1">MSVEPVARPTPPEIEGYLYKMKRKSGINLTGSWNKRWFYVDTKRREFGYSQSNTQTTMKNSIFLDDITAVVSFDDYCFQVESKTRKFFLKGESKAGAAVWVKTLETYRAQLVAHEKYLASTPLHMKEAKKEDNNTDNNQSVVAAPSKGSKTIYRSEDKAGEPKGKEAKTVSSTPVQAWSLSDEMDDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XWF0</accession>
    <name>A0A6G0XWF0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_000618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000003">
        <property type="protein sequence ID" value="KAF0745041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XWF0"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0745041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="186" mass="21547" checksum="E04AF9C4D46A7FF5" modified="2020-08-12" version="1">MNLLKTFQSERPSLPSFPFTPSRYVYKPSLRLSMQDISAMFPEEDRLPVYTPRTSAQRRQLIAEREMEKRQSLIWQNAYSGYRRRRRLERKADSTAISTQDSSSEALTNPTCERSPCTRVRRGNSFHFQDGQLIDVKTVTNVSPYIPVEWDDASISMAYERHSFNGVDSAVEDILGRYSLPDNIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XWY7</accession>
    <name>A0A6G0XWY7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Splicing factor YJU2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_000284</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the spliceosome. Present in the activated B complex, the catalytically activated B* complex which catalyzes the branching, the catalytic step 1 C complex catalyzing the exon ligation, and the postcatalytic P complex containing the ligated exons (mRNA) and the excised lariat intron.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CWC16 family. YJU2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XWY7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005953"/>
    <dbReference type="OrthoDB" id="674963at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000349">
        <property type="term" value="P:generation of catalytic spliceosome for first transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03226">
        <property type="entry name" value="YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043701">
        <property type="entry name" value="Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111:SF1">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="209"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0745253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="281" mass="32081" checksum="D0CC0943CD645CC5" modified="2020-08-12" version="1">MGERKVLNKYFPPDFDPKLIPRRRMPKNKQIEVRMMLPFSIQCNACGEFMYQGKKFNSRKEDVLDEDYFGIRIYRFYIRCSMCSNEITFKTDPKNGDYATEHGCKRNFEPWRERAADEKEAVKAREEEEKGDSMKALENRTLDSKREMDIIDALDEIKAINQRHAKVDTDALLQKVKQTDDGDTKKDILDEAEIQSQMEAFRKRKLEAVETTKPAKQPKPDDNTLGTSTATNLLAPLKPSIKVKFKPTTAKPKTTNKPSKATPTPAAPVALVGSYSDSDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XXS0</accession>
    <name>A0A6G0XXS0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_000337</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XXS0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011494"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02205">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00246">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="3"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="WH2" evidence="3">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0745309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="24105" checksum="DE37836120B0A114" modified="2020-08-12" version="1">MSSALPPGWTAYKTQDGKEYYYNAQTKVTQWDRPKAQGKAASKAAPAGSPPASSSKPPIAGGGGDRGGLLAQIQQGTKLKKTVTRESTPLDAVKGSSSSSSASSPSPGGGGGGNPLFAAIAGGVANLKKTGRSTVSRNDPSPATDSTPPSSSGGGGGFADIMRKNREASARKASIGGNPSSSSSGNVSPVHNAAPVHAAASSFRKSLASLATSSDNSELEAQLNRIEAKLDKLLAHFNIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XXS2</accession>
    <name>A0A6G0XXS2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_000013</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="4"/>
    <dbReference type="EMBL" id="VJMJ01000001">
        <property type="protein sequence ID" value="KAF0745558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XXS2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012433"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="5">
        <location>
            <begin position="106"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0745558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="311" mass="35080" checksum="D3481C7800A1D9F1" modified="2020-08-12" version="1">MANDLAAWYERLSKSQPLDVTSLLRLIAMAKEHLAGQPTLLDLDAPITICGDIHGQFSDLLTLMNLDIGQRMLFLGDFVDRGSQSVETISFLLVRMMRFPDSTFLIRGNHESRQTTSVYGFQTECDKKYNGDSRVYKAFMDVFDYLPLGAIVNNQLMTIHGGLSPAIHYVDQIRMINRVMEIPSDGPFADMVWSDPDPKSNGFHMSPRGAGYMFGGDIVEKFLHLNHLEHISRAHQLCMEGYQVLFRDTFSTIWSAPNYCYRFGNLASVMSVDDQMVREFKIFHQAGATTQSKVEIPATTSTDVVDAGYFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XYC5</accession>
    <name>A0A6G0XYC5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine-threonine kinase receptor-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_000035</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat STRAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000001">
        <property type="protein sequence ID" value="KAF0745580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XYC5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005580"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032797">
        <property type="term" value="C:SMN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877:SF13">
        <property type="entry name" value="SERINE-THREONINE KINASE RECEPTOR-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="77"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="290"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0745580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="342" mass="36828" checksum="5509CF2EA216523B" modified="2020-08-12" version="1">MASLSSNNEGSAQRRQIPIVCPGHSRPLAEVQYCPSPSPNPNAAPSEPSEHYLLISACHDKLPMLRCGRSGNWIGTFEGHKGATWSAKLSSDGLRAATASADFSVKLWDAVTGDNLRTFDHKHVVKSVEFLRGGSWIATGGHEKLLRIFDLGSDASTPMYEMQCDDVIRKIVEIPSATSPSLVVTGDTAGNVVVWNIDNQTRVTTLHVGSAGVMDMEASRGGSILTVAAGSKVTFFDTSSWTEKFHVNMPITFTEEGGASLHPSLDRFIAGGSDTWVRVFGFDGTLLECHKGHHGPVRCLRYAPNGESFATGSEDGTIRIWQTDMHSVHATSVSHLPNPATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W2W3</accession>
    <name>A0A6G0W2W3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_019210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000497">
        <property type="protein sequence ID" value="KAF0721186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W2W3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004912"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0721186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="259" mass="29421" checksum="702FFDD76AE63455" modified="2020-08-12" version="1">MESEMSDIKESLDTSINSQAFGRAVKYTTVPTSDEQAHCEFFIKQLVDQAKLCHLSDEECKLLLGLKLTSDKVHPALNQWWIAYSKTKSGDVWTEIYFKDRFCNRTQRELVDNLFEESERAEGESVKAYAIRLQTILDDIDVPDHQGVVIFKRGVRHARAESCLDNTDKELTSISDCMKLLRTRQIRLDDPSVYQERLKSRPASASTNTTSSRTTYSDVSTTSTPEQSPRHTRKSSKVGFRDQATLEDTASCGSLEQAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W3B6</accession>
    <name>A0A6G0W3B6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Proteasome assembly chaperone 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_019057</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PSMG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000382">
        <property type="protein sequence ID" value="KAF0721590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W3B6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004086"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080129">
        <property type="term" value="P:proteasome core complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016565">
        <property type="entry name" value="Proteasome_assmbl_chp_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15069">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15069:SF1">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0721590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="270" mass="29539" checksum="21FC71DEE78B176F" modified="2020-08-12" version="1">MALQLRYPEEADFRSRVATVDSTTDDESSKRQVSACFRWSPYGRQQLQNKSVLSVHRLVVATGDDAARFAQCVVDATPDAQILGSLVLSNMMITESTFGSTPSRVCSIVSLSQDVVVVVAPYKVDEMHAWEWADALLARFAPTHIVSLSTLVSLTYDDDLHEACSLRKLLTSPNPLASMNDDIATLASPRFVTGIPAALLTFCHLHGLQGSLFVVLHHSTTSWRAILSAYLPILDLVQAKTTTKLSLIGDNDRSTSSFMGQNASFAELYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W3X7</accession>
    <name>A0A6G0W3X7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_019163</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000432">
        <property type="protein sequence ID" value="KAF0721371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W3X7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002948"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000180">
        <property type="entry name" value="serine/threonine-protein kinase STY46-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF611">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="55"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0721371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="312" mass="34802" checksum="1E48316F635FD8BF" modified="2020-08-12" version="1">MFEAKIVVGTNVMVLKSFLFVSSSPQSCLERSMTELKSHFELIPQQYEEIPYQDLNLKELVGQGHFGDAYRAEYKGKDVVVKILRAQTFGESSDDIVQEFRHEATALSMFGHHPNIVPFVGASTDLSQPLALVTAYLPYGSLSQYLSKNEMSIEQKQTVLKDAAAGLLNIHEGRFIHRDMAARNLLIDGNLRAKICDFGMCRRVDSYGGSHFESGVGPLKYMGPESLSPPHSFSYRSDAYSFGVLMWETFTEVTPYKGLRGDEAAALVLEGKCLNACADGIPARYIKLMARCFYEDPSKRPSMTEIYKSLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W420</accession>
    <name>A0A6G0W420_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_018902</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000364">
        <property type="protein sequence ID" value="KAF0721794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W420"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021245"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0721794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="236" mass="26616" checksum="5550C3C12761B8B4" modified="2020-08-12" version="1">MGLATTIKVNRSVCDDRAICIFTATESSSMRSILNLFSREHMTLVVYFSRSVISLRRANKVLDMDANYVIAKPRGETDVRFQYAVDDFKTNFVFSSELEAVTFVGAVHLIQHLAVLPRPGKESPVSENMLSQFTKYALDYAEELWSLVLWQKSYKFHDIVDILRSAVTELRTSKPNMNSIALKFSDLTERFGGEASMEQVIELDSSACYTMTPVAVLLAQVSALYEHANCICRSCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W4P5</accession>
    <name>A0A6G0W4P5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_019162</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000432">
        <property type="protein sequence ID" value="KAF0721370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W4P5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020608"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF141">
        <property type="entry name" value="ANKYRIN 2, ISOFORM U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="365"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="432"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0721370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="661" mass="73584" checksum="76512FACC302E9D3" modified="2020-08-12" version="1" fragment="single">QVEEFVKAVRNGDAEAVKTLLDSGFDVNTQTTIQSTDCEGKDNMEGSVLMYASRHGHTDMVRLLLAQDRIDVNAKQKGRMQMGWSSLILAAANGHGEIVQLLLNCDGIEVNLSGNGQAPLHYTAIYGYIEIVQILLSNEKVDPNVITYVGGTPLHSAVKFGQVDVVKMLLEHGSCDLRLEEPFCGTVFEIAAAKGHVDILNILIDFSRDDSQLIHEQLGKILQRAASQRHLNIVEMLLRDFTASIDFESKVNTHFSLDNLYEIVYTECKRGTREASEHGHVEIVRLLLQQPRIDTNWSCETWGTALQSAARNGHLEIVQLFLANAKVERENLGIALHHASNNGYLNIVALLLAHHGQIINYHKKSGESALHSAANKGHVEIVRFLLERGIDINLFDEYLGTALHKESGSGHLEIVQMLLKHGIQNINCQDKLGRTALHAAAQGGRAEIVQTLLDHDNIDPNLKSEEGHTALDIAIAKEYDEVVRLLLDCSGSGLSGKVDFLPLQRDFECLIEAPAYAEPTYALQSGYYDIDTAYSQPKDEFYYSPLSPKASTDVLKNVRSFRELSSLTGFEKEDTVHFTAYAPPVVALESEFDFFIWALLANQWDDMEEQAIAADSRCRQLSREMMLSMRRGAVAHIIYKFQTVFSSWVAVQTNHCIGMGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W5N1</accession>
    <name>A0A6G0W5N1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_018707</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000349">
        <property type="protein sequence ID" value="KAF0722070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W5N1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018221"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="378"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0722070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="482" mass="51065" checksum="4658B8B3F5463929" modified="2020-08-12" version="1">MSAALEAASPSASTNSSNASTTVATTIAPATTAAQTPSATTTKTPTTAPTTTATSLPTTLATTPTTQAPTTTTAPSTTIASSTIASPASTNVAPTTTTAPSPTMTATTTTTTSLPITTSAAPPSTLAPTTSTAPSTSAAPSTTVSTSVPETTASNSVNVACLSDTYKCRNGQFVGRDPLNDCKFYPCRDSTEGPPHPATTLASTPKNTSAVVRFSMATTSSAYNWTSIDEAIPLSVVDSVHESFRRYNVSNVCDNLGVAITSAERAIVNDTLKQNTSLYHVLVDVNCTLQGVNQTTGTYVLEFVSAQPIIRLTQCGVIENGTLRNWLAVHNHATMCQSPPERRAFLVQPLEHTMHFTENKTASSMMSDLAAILEKPTVWHLFAAAVAIVVLLAFVFAVVVGRRRIEEQKRRQMERSILEEVATGRIEQRAREAAAAAAAKRKRELGELEDEPSPRDNPLDTEKALKEHDARKDVFTIEDEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W643</accession>
    <name>A0A6G0W643_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_018577</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000341">
        <property type="protein sequence ID" value="KAF0722244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W643"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001591"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36332">
        <property type="entry name" value="STRESS RESPONSE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36332:SF1">
        <property type="entry name" value="STRESS RESPONSE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0722244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="266" mass="30069" checksum="5280A3CA1226424C" modified="2020-08-12" version="1">MALFKAAQKHMDIMNVDILDDEDEVEQDSEQDSDEEDDDEDDEIEESGDEGDDDEDEMEERTEIDANDEEGDESDEEAGEEEGERPAFLDDFIPVTIDARNAFRCRVCPKIQLFNEQDIINHVQSKKHRRASVTPEEIELLRARNKRKQMKRRLKHQAALEAKKKAKIEADSKAKNTSKNVDKKAKKTPNCDETPSDKAVDKKAKKESGSNVQKPPKSVSLVKKADKKEKSESSSKANVPAKKSETKPSDKSKSKVPTKKVKKVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W6T9</accession>
    <name>A0A6G0W6T9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_018349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000331">
        <property type="protein sequence ID" value="KAF0722509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013447"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="476"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="521"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="586"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="625"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="649"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="772"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1357"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1528"/>
            <end position="1545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0722509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1639" mass="183204" checksum="731C3913F086298F" modified="2020-08-12" version="1">MRRVSARRLLLLPIPLETAIQVLRRNTFQTNIRTTTPYCWADLDLRWQLAHTAKRQERCLAHDSQNAAVYLETMLRNSYNWLSSQYYLPMRTVIFDDINATVAGQAWLDDLLSMTMIPVEDELALWRLHNLTEWTSQVQNLAHEGFDDAIELVSALGVHQRITITSIADVRRGLSAWTTAWAYAGIWNDLFSCQVFNCSLVRGSPLHPDQLGLTWDKDIVLNYETDSPGSRLIRTYVGQYVSIDIRFVQIPLSLIQFYSSLDQHHISSRKNAESVAVTVDAVPTSWKSDDFVYYGGNLLCPFGEARRFVQQSFGYYDDCGPQDPHTIDLTCHSAAFAIAASNLQHNDIPGVCKACSTDYDICSEAITQAFNEETELPQLGLIDQVTLDVKALNLSIIQMATNVTAGNDILLMQKMIADGDLWSFFGWVTIWEWVDGQREVFVFEGDESSITIVSRPYGYLPLPANRLELPQVACQYIRVLVVYVSLILFSIGLVLIVFGALSRFDIDGSNLLSFNRVVGSVWLGRPLLFLRGMTAILVLSTGSVDFVQINGAATIISSRRSIFEVALLAGESTWVVYVLNDLFLPFTTYLSSLCAPLSSLLAFVITADIELTHPFQMTATISRTCSYKTLMSGIVCTSGVVSVGSVTRAGILVSVQLGCVVVAYAIIRIVNGGLKNPRVPPELTQHVAVPAAADAFFTTARGTTYNLDNVACVMSGIIPAFGFVLDVKLWTLFDAVKSSRASGLVLKRCSLGTKRKLEGVLASPAQKRILRVWSVLGFGYMGLSIGSSYTFLRLTESTMTNDFWWATFDLNNTQAYLSNWFNAQLTTMFNRATVHFNDLERALLVTMQNTTDPNVNCPPAYSSMIQDEVNSLPNVISALRQMKSCDILWIFSAYCFVDFEQTWELANSLARQERCRRQYATNGAVYLDGLFRNNHKLALCWGDAWDIAIFGTLRESNAGIAWMDKTLAAELSVVDEVTFWKEHGISHYSTQWQNFKSLGVIESVDVVNALSVAYPLTLKKSNGTFQLSRQTSYKMYWGLAGDLTSISRNGSTMYHKSLVRQASNFAFQNTTLEIQLMANNSLPTPLTPGLSLLRAMLGPFGSIDMYRVAVPPSLIQLHLNLTQALILPLANSLDAQVDFWPYYASSMVSPQPASWDKVYFWGGDVLCPEQPSPQLEIQVAFSLQGSCGINLNEITMVTPELAIKALVAAGMTYNISEGRSIEETCERATHWEACDHVLKVGNALIEHDIMSRSDVELYFTAAQRIKSAEIDINLFQYISREHNSMISISTPGLFDDLDFEFFGWVMLFEWVQGLREVVSFQGDIGAITLLSTKYGLTVSPADAMEVPLNLALYVHRVVQYFTFVLMCVAVIVVKYIIHSRGYIQGLNLFSFNRVAGLVWLGRPLVFIRGVTAITLLSTASLELRRPHAGLVAFLDAPPTNPIKTIFSAGEATWLAYILNDLFSLVTKQYTTSYSLKSSLLLWAAAATWSFLSPVNHSVEIGRMCSIVSVDSQIVCKSGVVRIGNDDRFVGLILLAIASCILCYAIERAIIRRQVPPSQKATSLFLYAAAKYQFRREQWEFMGVYYLDRASAVLNGILSLSMRGFHYVFDIKTWRLYIYPVEPQHPHEPMHLRYALPLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W7G5</accession>
    <name>A0A6G0W7G5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_017925</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000317">
        <property type="protein sequence ID" value="KAF0723054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W7G5"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051295">
        <property type="term" value="P:establishment of meiotic spindle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007051">
        <property type="term" value="P:spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051185">
        <property type="entry name" value="ASPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22706">
        <property type="entry name" value="ASSEMBLY FACTOR FOR SPINDLE MICROTUBULES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22706:SF1">
        <property type="entry name" value="ASSEMBLY FACTOR FOR SPINDLE MICROTUBULES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="450"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0723054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="892" mass="102206" checksum="7F8462D8FA559C39" modified="2020-08-12" version="1">MSSVDALTYDPEDLEELLNFSGSESDSEPERSSTLPPLQFVDLPPRPTAAKSTSKKAQQLKKFGVFHSPFGPLPKAVSPPSKRLHPLLSPSLPYVKKKTPTRLAQVTETSPSKMAFKTNDIIKHGELKVYMCRYTTIQPLFCIPFHETTTLAACRKRIDDLLMVELVDYVFVAPTGKTVATTAEARFLAYWFHPVLTILVTSINQQSSHPSPEKLLQALHPDLNSKSVAEQRPWNLSYASFGMFSSKELRMQSAIIQAPMGKKIRQRQQRDALRLALETPDDLASGAFEAVEKSSPALDPSTVQTILQRSHRDVLQHISEREYEKRKFRHAKIQQRALNLALDKHYKAIKIQAWWRMFLGLKCLQAKKQAHKAAICIQNLIRQRSIQRQQEQKARRNCIRLQKTPQMTSSATQFVYQAVDSKGVVKLQAIQRRRLAQKALREHPEKAQKYLELERRREMVRQSQENFEKQKALAQLRKLHAVERKQRKELNKLAFAARQDAAAVVIQSSYRRYRAGQFVHFLRRERSAAIKIQSHLRKNSALAKVETLKLQMRKSSLGGSAMDYAESYHPRLFCRRVWFRGSYHLLYSCVSKTHFLLVLHANGGGKHSDPIAIECFLDMNDLKTFGLLPSTTSVRIHDVDRLVESATAALTLSKGQYLLNQQDFHKFRNIGLNSRTLLLPNPEMYFGRMYQRCSDSNPPQELLRCFLYSAPTLIYYVAKRMKLGMAHLGFFEDRGVLYVECYISRWHICICVGLQYQEWAFSGLGVLSTCDLSQKIDISKHIAPRISIGHLGVRIDVRKRLFHLAKRFRIVENDATTTFATALFSVYILGQEMQLEVVFPNGWTLQCGVEEPLLRQLGYKDVHQMDMDTISILSRQMLSGLAIVDRKLCLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W7L8</accession>
    <name>A0A6G0W7L8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helicase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_018643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000345">
        <property type="protein sequence ID" value="KAF0722163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W7L8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015695"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005114">
        <property type="entry name" value="Helicase_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37066">
        <property type="entry name" value="HELICASE-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37066:SF1">
        <property type="entry name" value="LNS2_PITP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03457">
        <property type="entry name" value="HA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase-associated" evidence="1">
        <location>
            <begin position="116"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="1">
        <location>
            <begin position="193"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="1">
        <location>
            <begin position="361"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0722163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="515" mass="59631" checksum="14671C4010641382" modified="2020-08-12" version="1">MLTRVWRPCLLPAQSVWKAHWFSTWKPSISPEKQREILRVAQCVHELEGKPKRTNLTPFVFTVPATAPFPEDLHGTKFSIKVFRRAYHLGLLSEDIVSQLDAIGFVWNGREGMSIEAWEENLEAIRMYKSIHGYLSVPRSYKVKVGDVQWPPKLWGKNLGYAVVRLRTQQETMDPARREMLDSVGFIWDAIQANWEKNLLALETYKAIEGDLLVKKRFVVPDQDPAWPKDTWNVKLGYLVDTCRKKKASLPPKIRDALNAMGFVWKVRDPGTGPSRPPSISMKKQNQILEIVQAQYNLQDHTKFTTLPSPFKVPSSSKWSQHLHGCSMNTTYFRRAYRLGLLEASIVAKLDEIGFVWDDNQHQWSLLMEALEIFKKIYGHVNVPSGFEVPEDDPVWPNYLWGMKLGTRIGPIRRGQTKLTLEKRQELEKMNFIWDARELHRNVILLALKTYKEIYDNLYVPSRFVVPSDDPEWPPELAGMKLGVVVNNLLNRRATTSDELKKGLEELGFEWHRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W8U0</accession>
    <name>A0A6G0W8U0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">BEACH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_018307</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000330">
        <property type="protein sequence ID" value="KAF0722574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002283"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002284"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021910">
        <property type="entry name" value="NGX6/PGAP6/MYMK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46866">
        <property type="entry name" value="GH12955P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46866:SF1">
        <property type="entry name" value="GH12955P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12036">
        <property type="entry name" value="DUF3522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1326"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1366"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1397"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1429"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1451"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1483"/>
            <end position="1502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1514"/>
            <end position="1531"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="10">
        <location>
            <begin position="228"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="1009"/>
            <end position="1040"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0722574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1552" mass="174111" checksum="6BDAAE814C9533F6" modified="2020-08-12" version="1">MLSWDVQKERIFRALDVPFASPVHPKSYHSSQDDVTLVKVCTEDGHEWLVYIDSTKQRRDSSESASTLDEDFNHKSTISPLEHTEIHSTMPDDMSTTTLEAFLDRFYRAVESLESAASTMEPVHPSIAPLHSVITSTDGSVYVMCPMPKSSLHDISLQQRQKQEEMTFEMGLQFRFLIYQILLAAHHATPLFQQQLTPRHFVFDGFTLKLAPFVSLPAALPPSPRSLTERWCSGEVSNLEYLMALNAAAGRTMASNTSHAIVPWVTDFTSEHSLRDFTKTKFRLTKGDAQLDQMYSQTGYHVPENLTDLSVAIYMARALPRSILQRVVRSNFEPKEYPVSMARMFEWSPDECIPEFFLDPSVFTSIHKDMESVELPTWCSTPDAFIAFHRRVLESDAVSTALHQWIDLNFGVGLAGSKAMQSKNVTHRGFYQLFSYPHPIKRVGSPTRSLSSPEVGAVSPVVVFDEDYFALKQTKQSPKTNFDSTKVFGMRYAPLLEPCYNLDNDVRFSLGCIIAEIFLAKPLFSLQSLEYYVNNTQAVSNSTLLQANAMPSTVQQLVAGLVNPDRKLRPSIEDLLQIQNNKRVTHTSQSYLFPAYFTNVYEYLMLVTCDDWIERTEKLLEGSFPPEGFTLISSCVSVLLAKSTPVQAYESLVRLVPLLFHLLDSNKLREFVQGPILTLYESVDDNDGLRVCLISPQGMLGILWDQLGSCFVLKHILPILFDWLRQGSPLVQCATAHALGQLASCEMMGPSIGANDLLPQLLDIARKFKLKITKPLPKLLPPYAVGRAIVRLCSELHPTVVHTSAIPTLFIYVRQSLIDVNRQPPVYMTAEKYQLFMFLKTIRQLFAFLTPALASLHIPSLLRLLTLTKTCDSLTLSSLVHTTLRIAQIVGTDMTKQELCQPLRLFLVRFPEAQFPSYMQQFQHLLGFEHFDTCLGLPWSLSSATPSKIPIVKIPLPAMTLLTPKMAKVVVSMRSQLSPHTLKKHGPPSWTCATQLWPPTTGGDVLHELMAHDSRVRAFAVVDDFRWLLSSSGDGLVRLWRACDLQLVWQLRFKWPVYVLSAYARQQCVICDAQSVYLYDVTTRECKWQWKKPAQPLVAIHASPSGTLVVATADTVTLMDPKHGASSKAAVEWTVRGCVTCVSELYGYVAVGALSGQVALLNRGTGGIHCTWKGHDAKVVMVQAVSPTLFLTVGADKLAVLWRWPELQIVTAITNLPEKIEASQIDCNSRPDGSVWLVIGHGTRLATMCLSPQPPTGRRTKLVWLEAKSRQLIQAVVVLQHCVSQDSHQCLFDLVVVRYTNVGYTRSSESVAIHYHFTTGGVMDTVVNIASAAFSLGVAFPLRVASDLSVIPSIGLLKRNQRHFEMYIGIFHVFISCMTNGAELYGKAYNAPLFLAYAQWSNILDVLWLAFLYLLVVHHLSIKNENINIILRYVGFSLAWIMRVKDGPYEHSYSLLMVLVGFSLVVVRRLVFRDQFMQPLRKAGAAISVALALFCTGVYLFAYDIPVDGVILRSVFYCCLGAFFYFGWKCAPPPMAAAKKWDDCDVVTSDYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W8X4</accession>
    <name>A0A6G0W8X4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">USP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_017570</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000302">
        <property type="protein sequence ID" value="KAF0723557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016060"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF827">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="958"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="3">
        <location>
            <begin position="1536"/>
            <end position="1850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0723557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2334" mass="261716" checksum="1650801885CCDD1C" modified="2020-08-12" version="1">MNDSVVMPRVGEQQQVNSYSDFQRNCYLLENALGDSMTDPRPSLQTLQTWIDWVNRGMGTPKHDNHLYTHCLPRVANGFLRRSFNLFSDPEIPQHVVAFLVDLVRLLVLRFQQPDVSQTHLETIHNILNPNHLFYQCHGHAAASVTEIEEENTFSDQLPDDVSPGAIVDAFHPIHRTWLEAVVMNRDLNQVYVAFFGVEQEGDCWISLEGGRIAPRGHMAQGRRGQGPIRPDLEESIPDETDPRGETNGYPFAIVRPRVPCSHYFVELINTFGVIGGFQKLPILQGSSMSISVLTTTLSLLANIFPWLTRAWATELHAHCATWIHQYLNQVELRPVTKTMLDTLHIAYKSICRRLMNRHEASVQADTVLLQICLKCLHSSVLEIRLHGLKCVTDFVSMIRQAQVNPMGVKFVAASSVSHLSSPTAASPSMVVHVSITESTTKQQFAEWFASNKLLQLLCESHEQVIRRAPELVRFLCEAESFDLASLDLIWNAMLSSGPDVRASLFYLLESLASYVTIPVCSALLDKINAFGIGHANVLGLVGALAKYAPIESTLDEDMDDEEHLNFFVSPNPFHVNAVCRYRAMEMLWTTMQDSTDETTRNLFDTAKGHFQDAIKANVEDEWNAIVVGCVSYLLELAMQSLRDHLNVPQAFSILGYLLQLLEEEKTQIVRVLERQGLLQIILDDLLVFKTTYAPFHGRPYHVDEADSLVLPQLNALLLQHGSHVDYLDQLKARLGFLSLWLSIEPSLNWTFAQLALVWTTLNAKATITTERTMFFKWLTTNALHLSPSNVTFIFQELLGNEDFVTSNALTPLSLQCFLCFFRLTNHHHSRLVLDNVASVNTQNQFTIQRLPLMGMSTLWTILLHGSNTLVFTQTMKFLTLLPYKVVDGLEFHFLSDGLDHLRNLAETAPASKLRRCLLVLSSIIGTDEASALALATGQWVPHGKASRGPPLHLTINNTIKITATSGQKLHLQVYANDTVLEMEVAVAQRLDAQPLATKGLRFFRMGSEIHELSRCLTLAEAGFKDGDTVLVVYRPNIPLTPLVTRPPVVFDVQLAQVLMQIIQAQDPPQEAWDLLMRLPTPPAMVDDIRTHSDDWTTLFSPRLSVTQLLYRLQVLENLISTDDNMLTTFVTTDGPACIVDLLMSADDHDAQQFVVYLRKECSMVCLRLIMTFLSHSATYQEFDVPKATMTEFDPEHLNIDLLLVMELILSPYQMKASVAQEAITASNTAMQNHIETFVASMNYPALHAACSRIMSDALKELSVPTLDSALRVYLICAPYSPLFTTLPSDVLAAISSPHRDIRHLICHAFIVLAIDVTSRALVPAKCGPLAAQILALDSNDPPLQYYTLVGLFLFVAKQVQLPLATPQSLLEQQMRLLQAYRRPNPTTFLADSSQHLFGEQQHDQYLLGRLFIIRCLLAGFDELQTFQPDLLLDIWNNCLMAYPSNTGDPVWQPRCTTSTTRQGAFCLLVDLTKYPPAQPQESSKNGTPIVDVTNANLAFIMQQIPRVVHNVKQFHEDWEWQWDPHLQMKATTTYSGLRNLGCTCYMNSTLQQLFMIPSIRSAVLSMDVSDPANDPSGLFKQVQRLFAYLQATELKSVDPQPLIACLTDEAGGPLNVMVQQDAEEFLTKFCDNLGEFLKKLSTPPLFDGTICTQLVCQGGCNTIRETAATSFVCMTVEVKGHDSLLHSLKGWSDGELLNGVNCDACGSKQDTMKRDCMATLPTTLLLHLKRFELNFDTFLREKVNDEFSFPLTLDMFPYTKAGLQGESGSEIYHLVGCVVHMGSTESGHYYSLIQDRGSKQWIEFNDENVTPFDMRMLEAECFGGFHESTSSGGGIISHKSAYLLVYEKEQHLQNPQVTAIPPLPPSIVSDLRNENEAFIHACYAHEQEFLNFVCTLLEQLPVETEMSIDMPQWSFIIAAVECIPLYTRAFTTSPLQLITLVTKHIQCPTLATYILGQFVKKLSVILDCLLHCTKSAVRTDFAGLLLHLCSIAVVKERLMVIADAQRSAEDDSQSIVGRLVDVIFLFTMMDNVVSHWRQMHEFFTFVHGLATLDPVVRDLLRARKCGMYLLDLYLGDMSPLMGKQYKAYSRKRLPKTLPPSALVLPLATVALLYHDQPHPSVDPETRSCLLLRTLYIKAFAHAEHAKAISALLVQWSWEWEAFTTSVISVVGEVVASLSTYSTTISGLVWVLDAFLGLTDSLQETRIANWFEVMWKSIDGLKSAQAQGQCVGVLLIMGHRHPAVHACLVAHLDTWGPSGGAILGLMAKQPWTLLMEMEDKTAIEWTHARSHDRMTQLLIENGRSLEWLEVQEDMADALDDGGDPTAYLWDAAID</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W921</accession>
    <name>A0A6G0W921_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_017468</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000297">
        <property type="protein sequence ID" value="KAF0723693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W921"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013242"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052050">
        <property type="entry name" value="SecEffector_AnkRepeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586:SF3">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0723693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="424" mass="47238" checksum="F35409D85FC19047" modified="2020-08-12" version="1">MGRITCLWQSPPAERAALHSFCRRDSKGMASLSVFRVPELVIQVCQYQQGKYPHLAPLLSCCIDYRTFKVDDWYYVKHMGPEPLRRFDQVFQAGFAIYGYAGLRHLLNQEGRPMHIILSAYAAFVGNMDLINYLANHRALESTRFVVDTAALQGHLNVIRFLHARKTSGFSSRTMDAAAHGGHLDVIRFLHAERPQDGATRNAMTWAARRGHLDVVAFLHANRSEACSVGALDWAATFGHIQVVKFLHENRSEGGTTEAIDGAAANGHLDVVRFLWEDRNVEGCTAQAMDGAAGNGHLAVVEYLTARGAPCTVAAMDNAATYGHLQVVKFLHLNRREGCTTRAMDGAARRGHLDVVRFLHDHRQEGATEAAMTLAARSGHLDIVRFLHEHRQEGWSMEALVDRDQVENPHREVVAYLRSIIAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WA90</accession>
    <name>A0A6G0WA90_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lipoyl-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_017103</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000279">
        <property type="protein sequence ID" value="KAF0724160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WA90"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012159"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004149">
        <property type="term" value="F:dihydrolipoyllysine-residue succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050537">
        <property type="entry name" value="2-oxoacid_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416:SF5">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="4">
        <location>
            <begin position="21"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0724160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="213" mass="21994" checksum="0B73281DEABAC56E" modified="2020-08-12" version="1">MWRIAVIGKRAFHRTPRVAVEHIVKVPSMGDSISEGTVVSIKKQIGEHVAVDEVVMVLETDKVSVDVMSPTAGTLVKTLAALDQDVQVGKDLFIVDGDVAATVVAPAAPAAAPAAAPAAAPTPAPATPVVAAPAKPASSHARVPRIKFLGKRSLLPAGGHHETTNVAAPVASFVLPPSSSASVLHFTDIPSRFARKPISKDEIKAINTGYGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WA95</accession>
    <name>A0A6G0WA95_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_017637</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000305">
        <property type="protein sequence ID" value="KAF0723483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WA95"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016256"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46225">
        <property type="entry name" value="C3H4 TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46225:SF19">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="185"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="255"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0723483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="316" mass="35315" checksum="AD3ECFB17E7B46F4" modified="2020-08-12" version="1">MAQPRSTPVPSNAPPTSRSLGEAQSGDHSRLLNALPSHEEVRDVRLNVLNTSVQGAREAGSTRLMLIFSVVVNLPQVVAAAVVMGLFWNDPDLAKCNRLRYWTLVQTLHLLFTVLVEWAVYYVHILHPRARWSTPVVKNMLNSLKYSLELLGLFWFLVGNMWVISDEEHCALKAGGHMYNLALAMIVICYVKIFLPCLLLVALLPIVCFCLPCLIRILNRIHDPMRGKGASKETIATLPSVPYSPSLFPKEDASCCICLNEYTPNQTLRVLHCTHHFHQECVDEWLVVNATCPTCRKPIDPNAVPSSTSDDPNLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WAJ6</accession>
    <name>A0A6G0WAJ6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_017769</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000311">
        <property type="protein sequence ID" value="KAF0723286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WAJ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012881"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF288">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="3"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="36"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="69"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="102"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="403"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0723286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="668" mass="75404" checksum="D4C914DE8DF9D521" modified="2020-08-12" version="1">MSQTDKELWYAARRGDLRRVRSLLASGANADYQNKLGKTPLIEAAWKGNFDVVKDLLAHGAAVDQADWNGYTPLHWASSYGNLDVVNELLAHGATVDPINKNDETPLHQAASKGEVDIVERLLDGDANRLLENKDGKTPRDLGNDDVKALFDTYQPKTKLYSIHEATDVIRQAIADIHATSDTLAIGSAILNLSLKAQVLRQRVLATALLVEAAMRQNMRQESVDPSPALSSVLQDIQLCFETKLVTTQSWKMTFSVQMVDELRGKMDNLDARLAKAAKFNVCYQVHGTIDDLRHAPGKMMDKMDSIDEHLALITAMSKHRQTDSLFEFAIQVQRGLENYHRHVEMGNIQRNVDFEAQVEVGKSKIWRLINLMGHAEPMSTEQYAQSIQSWMLSSDDVQFDPNDMETALGRGGFATVFKGSYYGQDVAVKRFDQIVQTDSVALEKMIAKEIDGWKDISHEPYILTLVGVCTKSPVPLLVSELCETNVRRHIRHWPSALLPLVYQFACGLASLHRANMIHRDLKGDNVLVTFHHTVAIADFGLSRSVKSLENTNTNVKRAGTLNWMSPEQYFMPRSVTSKSDVWSFGMTLWEILCDDTPLRICSEDEFRNEIYQREDDRPEKPQHLKPALEPLWTLITKCWRLKPEARPSAEEIVEYLKQEFGSQLASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WBD0</accession>
    <name>A0A6G0WBD0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_017586</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000303">
        <property type="protein sequence ID" value="KAF0723553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WBD0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007283"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF214">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="197"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="101"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0723553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="467" mass="51804" checksum="667FD7F0E431ED4F" modified="2020-08-12" version="1">MLVAWNGFGMRLAWRLVVPMDRFGGIEGPNSSTTTNSTRTTPSPFDEFTPSSSLYDYSSSSSSSSWFSAHKTIVIGAGVGVIIVLAIIIVICCKCRKKRTKEMTGSTTPQAPFVELQDDAPPPPMQNPPPQVKNPPPAPPKRQSSTIATTETTNSSFRQSHGSNTKSREESSFRGSVPSEALDMCGLDVHRIPSAEIKLVRSLAQGAYGEVWLADYFGRPVAAKRLLPGKNSIDEVQKFIWEIKLVSKIECPFIVEFVGVAWTRPVDMMLLTEFMERGDLRSVLQQNAIERTFTWQHKVVCALHIAEALVYLHTMDPKIIHRDLKSRNVLLNSAFEAKVTDFGIARETDDIQTMTAGIGTYRWMAPEVLQDGHYTDTADIFSFGVILAELDVEVLPYSDLRNDRGNPYTDAAIMGLVIAGQLKPSFSPECPRWFHDLGLQCLQIDPSARPSAMQVAYQIRSRLQAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WC72</accession>
    <name>A0A6G0WC72_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sugar transporter SWEET1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ae201684_017301</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SWEET sugar transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000292">
        <property type="protein sequence ID" value="KAF0723921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WC72"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016081"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051119">
        <property type="term" value="F:sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000007">
        <property type="entry name" value="Bidirectional sugar transporter SWEET7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000004">
        <property type="entry name" value="Sugar transporter SWEET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047664">
        <property type="entry name" value="SWEET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004316">
        <property type="entry name" value="SWEET_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10791">
        <property type="entry name" value="RAG1-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10791:SF30">
        <property type="entry name" value="SUGAR TRANSPORTER SWEET1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03083">
        <property type="entry name" value="MtN3_slv"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="8 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF0723921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="282" mass="30805" checksum="A3EB1D12B05A1F18" modified="2020-08-12" version="1">MALSWKGQEFMGTASLTTTVLGHEDFVMVMKRQGCVFIALGTVVKIAASASSFYVVASPYEMIKTIHENKSTGKVSVIPFQSMLLSSSMWLLYSILLRNFFPLIITNVVFVSVVLVYLTVYYINSMTKAKLHAMFAAQGLFTLSVYMYAALSTSPMNDLIQTIGFIAITCSAIMVVSPLSTIVEVIETRSVAHLPKKLILATWISSVAWWLTGIIFQDAFIIYPNAVNAALGSLQLFLFVVFPSTSTAVAHLTGPTILDDSVGLLTSVEDIDQQLLATSDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WD11</accession>
    <name>A0A6G0WD11_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">CBM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_016299</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in degradation of plant cell walls. Hydrolyzes the feruloyl-arabinose ester bond in arabinoxylans, and the feruloyl-galactose ester bond in pectin. Active against paranitrophenyl-acetate, methyl ferulate and wheat arabinoxylan.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the faeC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000248">
        <property type="protein sequence ID" value="KAF0725214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WD11"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019990"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043595">
        <property type="entry name" value="FaeB/C/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38050:SF1">
        <property type="entry name" value="FERULOYL ESTERASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026193386" description="CBM1 domain-containing protein" evidence="11">
        <location>
            <begin position="20"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="12">
        <location>
            <begin position="19"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="55"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="66"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0725214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="275" mass="28450" checksum="9CC068288E5A060E" modified="2020-08-12" version="1">MKIAGVLAAILSSAALVQGQVALWGQCGGQGYTGSTTCAAGAVCNKQNDYYSQCIPGSNNPPPSSNPTTAPTTKPSTPSSAPPSSSAPPSNGGSKSPGCGKAAGITSGTFSIQVNGKNRQYIVRVPQNYNPNTGYKLVFALHWYGGSMNDAAAIEGGYYGLQALAKESTIFVSPNGLNQGWANAGGEDVKLVPFWTRSTRASAWTRLKCLRLVSATELLSAPRWRVNVLTSSALLHCTLVVVAAATPSRLLSGRLTALATALSPSRQAELSAITM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WD20</accession>
    <name>A0A6G0WD20_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Leucine-rich repeat-containing N-terminal plant-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_016341</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000250">
        <property type="protein sequence ID" value="KAF0725109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WD20"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020266"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0725109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="30797" checksum="A55DF7DC58EF3A33" modified="2020-08-12" version="1">MVPNSSDLSYNIIREISTPMPSSLYFLNISHNTLQKNWIQTPLTVSVLDVSYNEGGMAWMPNVLWGVYLPKLSRLVFRGNQLDSLELSYNNFPMTPLAYLDLSDNPNLILSVDSAVWNRRDSLVLTVKQTLYEKIVHICDAKHGMVYSMLLYAVQYLPEGNAIYDTPYNRADIVTNVCFLGYTPPPYIYTTSYGDPSKAIFMQIILTVGLFSIGVLVAYFVGRRYIKRRNERTPFRRGTFCSYNASGYDNPSTEEAPPTAYSLPPPTPRQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WDR1</accession>
    <name>A0A6G0WDR1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Endo-1,3-beta-glucanase btgC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Laminarinase btgC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Ae201684_016810</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation. Active on laminarin and lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000269">
        <property type="protein sequence ID" value="KAF0724516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WDR1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007174"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF17">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE BTGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="464"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="315"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="318"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="366"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="445"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF0724516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="527" mass="53983" checksum="17341E53D00534E9" modified="2020-08-12" version="1">MDELSTPTTPAGPVVSKWTFSPTKKKIASAVAAVGVLGTTAAVIAVNTNSNVDKESTSVRTSAGACSGVTYDSFQAGDADKHFAVIKSRFSNVRTYQTLVEGTTKGSVNLIDIGAKAGLGMACGLWIRMGDSGFFDRDLKALVDGIKRNPGTCQQVYVGNEDISSGVSKDTLLSRIGAAKSALKAAGISVPVGTVETDGVMKNPANSDLAGACDVIGINVYPYTSGAGINDLTIRFNAVASMYGGKVHLTETGWSSAGAALATFDNAKKYWTDYQTWKNSNGGECPYYFQFHDVPIKGGDEGHFGLSSDGSSWKYDIAPTPTTAAPTPAPTTAAPTPAPTTAAPTPAPTPEPTPAPTPAPTPAPTPSATLDTTNNATNSTNSSTTWVPTTLEPDTNSTSSNSSSIVSPESVSNDVPGAAETDASASSPSTADGSTPSAGTSSTGKDTTVKTSDGDNSSSNAGTIVGGVLGAGVGVAAIAAVIMFAIRNRRRVEEEKQLDFQTGDFFVESNRSSQLSAWQRAPSVAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WE20</accession>
    <name>A0A6G0WE20_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_016259</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000247">
        <property type="protein sequence ID" value="KAF0725242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WE20"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001634"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001635"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34859:SF2">
        <property type="entry name" value="LYSM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34859">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0725242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="344" mass="37002" checksum="D0BD165D7FF7F171" modified="2020-08-12" version="1">MSLNSAAASVWILHQSWHANDGIVTMRRRFIALDTLANSSAGFCLKNSYGRGAGTMPQSCDGNQDHLGLLCYDKCPTNYTRQALDCHQNCPSDFEDQGLFCRKADYGRGAGYPWKFGDGFNLNKARKRCENITALAIAKRAARSFTPSANLATTPLDAAFAVLPNCSKYVKIDKPHSGKCSTGLQSQAGLCYKPCKSSYSGVGPVCWAGNPSGWVNCGFGAAQSPQRCAEVIQDQIMSVDQLAFNILTEGEAMEAGEGMKLQDAFKGIQGKDVIKQAMSKLMTAFGDMTKLDSSTDPADIIRLAAGIAAMFDPTGVADVVQSYAYSTCDKYGAGQVHKRTKPDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WEE0</accession>
    <name>A0A6G0WEE0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cilia- and flagella-associated protein 58 central coiled coil domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_015741</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000231">
        <property type="protein sequence ID" value="KAF0725890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WEE0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018717"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049270">
        <property type="entry name" value="CFAP58_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32083:SF0">
        <property type="entry name" value="CILIA AND FLAGELLA-ASSOCIATED PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32083">
        <property type="entry name" value="CILIA AND FLAGELLA-ASSOCIATED PROTEIN 58-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21771">
        <property type="entry name" value="CFAP58_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cilia- and flagella-associated protein 58 central coiled coil" evidence="4">
        <location>
            <begin position="359"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="186"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="821"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="406"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="769"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="196"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0725890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="866" mass="101569" checksum="75DF20C720DD64E0" modified="2020-08-12" version="1">MGEEASEAAARYSAEMAAFLPTIPDEMGLFRQEVEKMLNALVKSQESEARLVRRTKEIVSEIGVNQDKYTREKEEELEAYNYKKKVQVDIEVMWGQVANSHKIEAEKQAKLNELRTNIAMLEEQLKNGSGWSEAQEEMMNKLRRQRAEGAREVENKANELAQIRMEVTSLQELVNEAEEEQQRLEQEVNDVNQQVQDKRSKAEKESRRKVSLEKQLKALKQDAETLNAEWKYKSEAVKTGEAMLKQKEATLRESKARMEKYLKQYDILFRTTHQFTEAMEGQWQKNVELQKENTQSEANIAAKEEILAKLQKDISKVEQLVSLTKEKIAQVDQSKETIDAKRDEYKRSLDELVNVTIEVERKQGESMRKTRDDLLRQRELVNKMLVRAADTAQGTHDLTKIKENTLKNLENEINGYRLSVKRQRDMVQQLVTERDRYEKEAEIANRKYRTAVEEAKLQDLQVASLQDKITEGETRLKQQQNLYEAVRSDRNLYSKSLIESQEEIADMKRKFKIMNHQIEQLKEEITTKDHSLVKEHFDHHKVDKDKETLKAELTRIKKQIQSSEQIIANQEQEISKLASIIQEADDEKQRQLKEYNAVVNDRDNLRAQLILRNEELKALYEKIKIQKSTLNIGQAQYLERAKEVQQLEKRVQDLLDEHKKTQNQIACTGDLKAELVRLEGELLQERTKIKALSEELDHPLNVHRWRKLEGSDPKRLDMIRKIHSLQKKLIKKCEEACMKDLLIVEKEKLYVELKNVLARQPGPEVAEQLLVYQENLKKKQAQMKNMENELDMYKAQVREYKRELQQIDRDMNNLRDKWFNSLREEPFPEQPQEDNEVPSNNEPVEKPKPQLPAVPSPIDESMFGLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WEQ6</accession>
    <name>A0A6G0WEQ6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_016586</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="8"/>
    <dbReference type="EMBL" id="VJMJ01000261">
        <property type="protein sequence ID" value="KAF0724837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WEQ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005071"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07414">
        <property type="entry name" value="MPP_PP1_PPKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000004">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF300">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="10">
        <location>
            <begin position="118"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="299"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0724837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="327" mass="37123" checksum="587E42304CB9D298" modified="2020-08-12" version="1">MDPIDVDSIIDKLLSVRGARPGKQVNLVETEIRALCMQSRDIFLSQPMLLELEAPVKICGDIHGQYYDLLRLFEYGGFPPDANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFILRGNHECAAINRVYGFYDECKRRYNIKLWKTFTDCFNCLPVAAIVDEKIFCMHGGLSPELTHMDQINRFIRPTDVPDTGLLSDLLWSDPEKDILGWGDNDRGISFTFGPDIVTQFLKRHDLQLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDATLMCSFQILKPAEKKKRSQSVHAPIPPPPPSNKNAAVDHSVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WEV5</accession>
    <name>A0A6G0WEV5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_015996</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000238">
        <property type="protein sequence ID" value="KAF0725554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WEV5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017072"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020160"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="60"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="808"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1006"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="578"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="821"/>
            <end position="836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0725554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1092" mass="121329" checksum="81A8397BDF73B82D" modified="2020-08-12" version="1">MDPRRQEDLNLGPTRTEAYNADTDMEPLSTNAVTESAIVAYTESPLATLRKRDLEYRRLHHANSPEQRDPEKRSRSLPAEPNDDSMGSDSGSDLTPLRALDANAAEQSDLSGSQLSLETRNSLEALPFWESNNDSALPILDLVEYENTRLPIVNSFAATRESYVEESIVPFTQSTETALLSTRPITRTITSTVSRTITETLSSQTGQYLLALPEPDGLGLAVTQHNTATASQGLSQLPALTSDLLSSSSTGYQSQAQLANAESRALEWDQSFTPDPNLNLQLTQQVNQSWPQCHLAATHMGANLLESTNHSDALTAVSGLSYTATSTQPERPLQIADLPHEDPSATDMEISEIDHGLALLPTVSDLSLRVSDLQDSVRYTESSVSLQLNQIQVDQRGTNTALGSLTSAVDVASNRTQLLEEDLSSLERNFSSTRQDLQARVLQISDQVQQVGLTLETASSVTDAQIFDLQRSLAETVPKETHEAVIRTLTEAILELRQSMQDQASISHQLRSGLLSNEGRHQTELHQLHQEVQSLRLLLSDSQTRTPTKLSETRRLLDELKESNELLSACVSDLTLDNTRLLHQVSSLEDQLARHQLDLQVLRNQTPEPQQATESSSAPISIDPEEVQALFRDLNERLTSLATGLTSDMSDLKESIQSMDQDKKLGQATKFTIVPSSNHQDDCAFFIRQLLETADRCQLTDTDRRSLLGLKLCSDKTPPSLHKWWISFAKTKQGETWPDVLAEFQDQSYATRLQSIIDEVGFPADQGVNLFKLGVRHLKTESCLENTDRELKTIADCVKLLRMREVPLDDAPTPAPRPKSRSGSVSEASSTYLSEISSDRTPLRSPRLNRRGSRVSFDEPSTVEHLLNALVDQQKQFVAHIERSDRNHQSLVEAFLRPSGHHFAAPVQSSPAPQYSQPYGYPYARPSTMTPPKHYTKYGHSSDRTNYACPEDAHLLMAPAAIEDEDLWLQWFSDTLSKCGEARKANRDFRTNGPIARIGWADTNPYSVIDNSDPLETPSNNESDGEHDDIPPYHVASAHGPTPTFKTRNSPEGSHLPPPPFSWDDLPTEYPDLESSPIQEAKQKIRCQHNYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WGK8</accession>
    <name>A0A6G0WGK8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Histidine acid phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_015395</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000219">
        <property type="protein sequence ID" value="KAF0726279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WGK8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002509"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF110">
        <property type="entry name" value="2-PHOSPHOXYLOSE PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0726279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="423" mass="47714" checksum="157B06476208F74F" modified="2020-08-12" version="1">MVTTRRGTSIESTPTATTPRKAKKQAPTVSQPVKEEDLTLKHVLVLFRHGDRSPITTQVGQHLVMDAAEKELWASKLPTDEHIEKLSKGAKVTGMEPHLPPPKAPRDGGVFPNGQLTVRGLEQLEAKGKALREHYSTFLNGIHESDVYIRSTNVRRTIRSCLSLLHGAFPELVGDDRLHIRINTDVTLEPSYTQADYQRLLARYKDPNHPRDNLPPLPDSVGCTKTLDEQIRKVIGIPEDESICYTSLREVLVCRNAHDVPFPEGMDREMCQKLVDYNTWEFHALFGDDEDCYNSFQKGVDEIFTRLHGHTTGTFHQKANLMACHDSTLIALWNAMKLEAGIVFPVYGALTAIELYQDKAGAWFLQVKVDHEPIHFKGHKHALLTPFDHLEKIVHAFLKKEAKRAADEEHEGHVAKKAKVTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WHB1</accession>
    <name>A0A6G0WHB1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_015197</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000213">
        <property type="protein sequence ID" value="KAF0726572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WHB1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020945"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051831">
        <property type="entry name" value="Bromodomain_contain_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22881:SF27">
        <property type="entry name" value="BROMODOMAIN CONTAINING 7_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22881">
        <property type="entry name" value="BROMODOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="25"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="112"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0726572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="332" mass="37719" checksum="2DD1EFC1F5E2DA66" modified="2020-08-12" version="1">MSCGRAKVHDEDLKESMTRLLRTLVKKDAYELFYRPVDTREVPDYLEKIEKPMSFSIIEKNITRQAYHSLDDFKSDILTVFSNAQQYNMENTIYFREATKLASLARELFHDTQEPTRSRPLEQSHNATIDRQLNEETEGPDTQLEMDLPKFDLGIRLPVVETNAYLADTEDDEDIEDFEDVCSQDLDGYHTDSSYVFDDIIHAPLPDSPLVIAKPSVAVDAVADIDSDSSLSDGIDYEVSVPPPRPQVVEHRRPLCDKENRPDVTDKGMEWISTKRRAPSGATSSIDVTSPPVKKAYVPRPYKSIFGEKGPPRAKRQALMDLYVNSGRQNDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WHI7</accession>
    <name>A0A6G0WHI7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_015247</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000213">
        <property type="protein sequence ID" value="KAF0726627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WHI7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006006"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052980">
        <property type="entry name" value="Crinkler_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33129:SF1">
        <property type="entry name" value="ATP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33129">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0726627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="439" mass="49583" checksum="86A9AEA64374FF18" modified="2020-08-12" version="1">MASELCVWYILVDTNQTPMMEESSVKMQSGPNCRIDDFKKAVHAENSRTLKLIDAAQLDVYSNMAELQAENPVVLNPAKGMTQYDANMGCPLVVVAPVPSATEGPYKKQRVDIDPHPAPELPQIDISGPYVMIPAELLQMSAIGSKRDILLYRRAQVNELWQFLNDRVIAEKKLGYIVGPPGTGKSMATLSFVASLDRTQWRVIWIHLAKQFCSTFLDLGTNKSSLFDPLKFEFPEYLDGQNNLFVCLDGLDSIQGHNEMLRSIQKRLGRHGSNRFVVCSSMATPGKRKREDDKQVGVEFFHMHSWTRDEYREAVSNPEFFNLVKDNLDATLPSDVNDPTDLTSKDHLDDMVDLKFYYAGGSCRYMFDYQTQEVKLELRTGIISAMGKPRLIEDGYNEHQINKLFRVDKALDGDDEQTAVSGYAQSLFVEECGTNMFAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJ51</accession>
    <name>A0A6G0WJ51_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_014671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000199">
        <property type="protein sequence ID" value="KAF0727254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJ51"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004207"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0727254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="486" mass="51813" checksum="3003B47F629CA213" modified="2020-08-12" version="1">MPDAPRRPRNHELYPSLAEPSSAKSNVLSALSTPPSPSTSLLLSQQDDNDELLQSSCKERVVIEAHICFCRLTRASFVTMRLALPLLFMASLAMAQDFSRDTPLMRGLSESTVDGWNAVDDERSLMLAVAKVAAPKPATVKAVAPAPKKAATPAAVRTATTATSSLVKPKAPLTKSTSSKVVKDTKTGAVKTSKKTTTKKAAAKTSTKKAAAKKTGTKKVTKPTGAKKVVKKAGTKKAGAKKTVAKKGTKKAGAKKVVKKGTKKTGTKKSVKKGAKKTGAKKNVKKGTKKTGAKKVVKKGTKKADAKKGLKKGTKKTGAKKALKKGAKKTGAKKGLKKGTKKTGAKKSVKKAGVKKTSAKKTVAKKNVAKKTGTKKTVAKKAVAKKALKQSAKINRNKRSKSTQRKGSKKTSAARRHNASRKNSASRRRSSRNSALRRRSARNARRNRRSSRSRSRSNRRSRSSFGGLGRSSLSSFGKYARVRSYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WL33</accession>
    <name>A0A6G0WL33_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_014102</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000184">
        <property type="protein sequence ID" value="KAF0727996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WL33"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014430"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0727996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="217" mass="25227" checksum="75AB3E851E033903" modified="2020-08-12" version="1">MRPDIAFSVTLLSRHLNNPEEEHQHIAKRVLRYLQGTKDYGIRYTKQDSLDYIIELFVDADYANDATTRRSTSGYFLFLNGCLISWKSKLQNIVALSTSEADYISMSSGLQEALWLKSLLEELELSIKLPIIVYEDNQSTIKMAENSALQQRTKHIDVRHHFIRDLVPEHMVKIEYCPTHEMLADMLTKVLPRPKIQEHLSKVMTPLSHYTEEESFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WLA5</accession>
    <name>A0A6G0WLA5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_013927</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000181">
        <property type="protein sequence ID" value="KAF0728098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WLA5"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0728098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="187" mass="20030" checksum="0901F52FDE6CF506" modified="2020-08-12" version="1">MPFPLVNDVSWCIPDFSKASSKAVDVNSGPPSDRKTFTLLPVCVSDQDIILAQFSSCVEASGLWYQRPNTPLAGMISCASLAWDFGHFGLNAAFAFACWIGQVVRCPQAQDAAPVDCGHGHGGCVGMYSAVGRQLKCIYLVGCIEPCLGYGYSFVLDEALIIFEVVCLACLQPRAPPPSPRLSLSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WLR1</accession>
    <name>A0A6G0WLR1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_013878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000180">
        <property type="protein sequence ID" value="KAF0728226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WLR1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003017"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0728226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="242" mass="27022" checksum="BBCCBC319C505FF3" modified="2020-08-12" version="1">MSTAKCPLKRCQGKRGCICPVSTNLPSGTFSAKTTRFSTKTTLPEIAVKDKPKTAKQPKKVVKASLTKEAPAPAMPSVKPATPEPQIQTPPSQDLNNNGNVIVRYNHYKKEFAIKNGSLDAATIDGQYFLSAVFPKSKLYLSRFGPSDFSFESEGLPHCGETYWVHIEEDAEERVAYEKRQDEYSAARAKDRAAKDDKPNIMREKVESCSCIEGNPCVDKYCCKDWDNRYAVAKKHGWKGFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WM36</accession>
    <name>A0A6G0WM36_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_013757</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endomembrane system</location>
            <topology evidence="5">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000178">
        <property type="protein sequence ID" value="KAF0728393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WM36"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002378"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13683">
        <property type="entry name" value="ASPARTYL PROTEASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13683:SF375">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="419"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="10">
        <location>
            <begin position="52"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="457"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0728393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="503" mass="55203" checksum="CB21AE15046DF61D" modified="2020-08-12" version="1">MLVEGPTDHGGIRVNLRRKVQIPTRRRLVDANTTSNEIQFDEVPLGVGVGTHYAEIYLGLPPQKASVIIDTGSHMTALPCASCIDCGEHTDPPYDLTKSTTANYLTCAEYGHCYSCESNQCRVTQSYAEGSMWSALMVSELCWIGSLNEKNAPFYLSHYGIRFPIGCQTKETGLFITQKENGIMGMSQDPSTLVPTLVQAGILKRNLFSLCFADTGGTMVLGGFDPKLHLAPPMYTPLVSSTGWYTVEVLDILIGNTSLGVSPSWYNSGRGVIVDSGSTDTYFSSSIRSSFESLFLKVAGRQYVEEESFELSLAEQRKLPDVQIVLRGSSAGSSVVLTIPPRQYYTTTTEGTLINNIHFSQGSGGVLGASTMMNFNVIFDVDKRRVGFAPSQCNQDDSNSAGVKISKGQWKDKTFWESYGTIVSIALLCSLIGVGIFGARFVWRQCRKRHWTQLSAEDVTPRNQPSPLAVEDDDSMMHTPASPQRKLSRSPDLHSIQEQEDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WMA2</accession>
    <name>A0A6G0WMA2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_013815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000178">
        <property type="protein sequence ID" value="KAF0728452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WMA2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012640"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0728452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="176" mass="19298" checksum="D008FBD44886C7E5" modified="2020-08-12" version="1">MTAAKDVLRYLKHSILGGPAGDLVGYCDADWASDATDRKSQSGFVFLLGDRPISWRSVKQNLVATSSVEAEYISLSSAVSEALYLKQLLVELGVASKTVVIHEDNMGVLHLAKNPGHHDRTKHFDVRLHRVRDYVSSKQIGLVHVRSQDQLADGLTKPLKGVMFAKFKKALLVGAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WP93</accession>
    <name>A0A6G0WP93_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_013167</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="VJMJ01000167">
        <property type="protein sequence ID" value="KAF0729190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WP93"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018322"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004868">
        <property type="entry name" value="DNA-dir_DNA_pol_B_mt/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48144">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48144:SF2">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03175">
        <property type="entry name" value="DNA_pol_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B mitochondria/virus" evidence="9">
        <location>
            <begin position="476"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0729190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="983" mass="112914" checksum="E2BD07E00BC52089" modified="2020-08-12" version="1">MSSKTNNAIKANKAKSVIYQQAKSLGLPVWWQMQAPRIQNILINHQRQFDAQTKIASLFKASKAKKQLNDLKALKRINAFQTTTILLDSFKRIRPSIYAPADKNLLVHFLDEDGSTLRTYHLNSHQVSIDDLYISQENEYSSGADVDLNILTTTMVRLEWIDDPKQSRSARKNFFRYLTKADYMLDQFQVYPESPDGLPQSSEIPCFLYALEQAGVSKTTVNKVKQIMFHLGITTNLLKKVAKKFNLRLDVKSYKLNANGKKSYNINSYGPHSKHVIHLGLTRKHIFAIKPTRITTFALNHPEFVKQEGSTEFALRNGLITYNSSRIKFLDSFEVISHLYHNRDELLIPITQSNVPRLLNNEYQKVDSLSEEDFSDDSFKEIGRVDGKMKFGQSPFNQVINRYTKQYEEIINFNVIYFDFETLVEDGEHVAYCISYIILKYKFRKLHSTGDTQHFYGFDCAEHFLEAIPENSHNLLWTHNAGFDLRFLMKHVSSFSQNSNIIECGTRLKQAHCFYKSSELIIKCTMSFINSKLANLPKMFKDVSKGLSLEKESFPHDLINASNFKSMWKLSYLDGFEDKDAMIANATKIGAVIEDQIDIQKYAIHYCNRDVDVLHHCFESFRSMVIDRFNIDVYRFISMPSIAYAIQHNQGCFDGCFEQNGVALGFIRQAIVGGRVMTRDNEKHHVKHQLADFDAVSLYPSGQSILPGYVRGRAKFFKDSVPETADYYIARVRFDSIGKRRNFPLSSIQQDGSRNFTNDIVGQTMVLGKQALEDIAEFQGVQYTVIEGCYWDNGFNSKIVDTVKELFDERLKLKKQGNTLQEGMKRCSTALTGADRNAEHTRKQIHKLISRTPITDDLALFEEHKYLYEHYSPAHLGVQILDASKHIMNEVMCLAEDINARIWYQDTDSMHIDRDAISKLAEAFRAKYGRELIGNQMGQFHIDFDLKGSEGEVYSKESIFLGKKNYLDVLACDGNDVEGHQFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WRC4</accession>
    <name>A0A6G0WRC4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prolyl 4-hydroxylase alpha subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_012496</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000158">
        <property type="protein sequence ID" value="KAF0730007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WRC4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011310"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF226">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prolyl 4-hydroxylase alpha subunit" evidence="6">
        <location>
            <begin position="208"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0730007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="662" mass="73956" checksum="8FA0BB301AA81B00" modified="2020-08-12" version="1">MKLSAWQVAGSIVVLVAVLVHRVFLSTPSTSQYVSVPTVLPALSQALGSGVALVDSKLIPKYATDIVSIEAQRFIAPQNCSSIPSPLSSTVHVTEAMTKPKNDSVIFVMLNGENSGLFFSWSGDASCLHALGHESALALGGDADWVALGVRLYTQLGDVIEDVADLHASNHIIHALFEFQMWMWPGIAIGHETVLDNGVKLTTNSLSPKVFDVSGFFTQEEAEAIIAQGEPHLVRSKVDQKGERGVSASRTSLTAFLPPSQLTRQLQVRATKTARLPSPSFGERTQLVRYNQGEFYKRHLDTFGAKDVIPRKKLNMTDFEIWAKWAAAKLDAMDKTLVPVRFQRGQPWHPLNKEIFPNTLLTAFASFANATKFFNARFAQAWADWLDFNLRSKATNILEELLENKGEYLPTLVRLWEDELGLPALRYTFPKEESPHGMAQWFRWVRVMKERISALGQAAPLHLQPNASLYPKFSNSFETKVLELWRHRTRNRGDTVVNAEWIAWLDENQGRRQVLSQLVDAFGQAVVLELIRVWEAAAQFDPVMHYTMPTYVPPISPQRFVTLFLYLNDVDEGGETVFPFAPAVKPTNESIFRPGMEECSQGLAVPARALHASLFYLQTPSFQIDPLSRHGGCPPVRGVKWGANQFMWNADAEEGAKVWLNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WRS1</accession>
    <name>A0A6G0WRS1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_012185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000155">
        <property type="protein sequence ID" value="KAF0730178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WRS1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014410"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052050">
        <property type="entry name" value="SecEffector_AnkRepeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586:SF3">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0730178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="206" mass="23162" checksum="210780C654DDB359" modified="2020-08-12" version="1">MYLIDQNYKTCSVFALDTAARNGHLDVIQLLHHRLKAPCTTDAMDKAAANGHLKILQFLATHRREGCTHWAIDMAARHGHLDVVQYLHSIRALCTINAMNHAARCGHLDIVQFLHENRSEGCSKHAMDWAAANGHLDIVKFLHFNRSEGCTTQAMMDDAATFGHFETVRFLHLHRKEGCTKAAMDYAAISRLLSFSTRIERKGATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WTB2</accession>
    <name>A0A6G0WTB2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_011846</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000151">
        <property type="protein sequence ID" value="KAF0730735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WTB2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000861"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01448">
        <property type="entry name" value="TST_Repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01449">
        <property type="entry name" value="TST_Repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051126">
        <property type="entry name" value="Thiosulfate_sulfurtransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43855">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43855:SF1">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="38"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="174"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0730735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="287" mass="32373" checksum="F8621BF4EEEBF1DD" modified="2020-08-12" version="1">MLKSLALTKAVPSRHLGRLKHTLVTPEWVVDTKDNLGIMDCGSPDGYKRGHVPNAHFFGLPSKDPKDPFQIVSESFFRSYLDKLPVDESTTFVFYDDAHHLQATRAWWVSRYYGIPRGQIKVLNGGWRYWVENDFEVSCVEPSTKDSSADKPKIVKDAKRVIDLDELKKIVAADDNAVHILDTRSEAEFTGANPNGNARPGHVPRALHFEWSDALQANGQFKPMEQLLELVHAAGLTPDKPVITYCQRGIRAAHTTFVLEEILDFPTVRVYEGSMLEYLNLPDTKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WU65</accession>
    <name>A0A6G0WU65_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_011550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000147">
        <property type="protein sequence ID" value="KAF0730998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WU65"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004802"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="1">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0730998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="147" mass="16489" checksum="666F1E09FB5D1B79" modified="2020-08-12" version="1">MSLASVRASVVDAKRDGNHTEYAVRVHALEQEAVVYRRYSAFVQLQKYVIRHLGEGQCCGGKCLLESFLTPVFESEFPNGNFLTKNSTKVVQDRVYFLNDFLAQLQEALYKCPPRILQRCEAEGCKVSKLLKSFLGIVSPVNPAGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WUA9</accession>
    <name>A0A6G0WUA9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CDR ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_011629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000147">
        <property type="protein sequence ID" value="KAF0731081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WUA9"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0731081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="113" mass="12667" checksum="F6E8727222190082" modified="2020-08-12" version="1">MGYNPPTSAIPSGFRWLTTITPPKYGLSILVSQIFSKCENGNHGMGCPTLKNVPTVILKQLGKSNVTVKEFTEFMFSMKYDNNAKYNVVVVGITIAFLLLMLLALRYVNFQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WUQ9</accession>
    <name>A0A6G0WUQ9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_011453</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000146">
        <property type="protein sequence ID" value="KAF0731187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WUQ9"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0731187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="196" mass="22386" checksum="A32DE6B48D3BC51F" modified="2020-08-12" version="1">MALAAAKSCAIKPWCGFREWTMQQVYYNTELAFLHWPQATLDEDVFALNLDIEDLSANIVVWSTPLEVAQYVLRHRLDEISMGSKPLAAVEWTDNTVSYRFKPAMPRFVGAPLKIHAIRHDLAERSCANEQISQRRSSTRWTRVSTKLCQCVWQLRQANDNAFERITAKVTPRMSCVCISQCLFGKEALDDIMSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WUZ4</accession>
    <name>A0A6G0WUZ4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_011527</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000146">
        <property type="protein sequence ID" value="KAF0731267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WUZ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005550"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0731267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="267" mass="30976" checksum="0BAF8DFF6B905640" modified="2020-08-12" version="1">MMLKLEEEHWRALKLSADRDKRLVEIHAIADQQLERIDSDMLTLGLLDSCEDVNFVRHDVAKNYSEGVLCTKFKAASFSRIENAIWRALAFIHAKTSWQHSILRVPIDKDTAFIRTKYAMPNSKRSLESGLILKNQMLGPRTARMVLRSILDDDANLFDHDSIVWDQSVWYDAIWKQRQFMPSRIHIEKCDDETVVYKSLVRGNFFDFNLDDIENVSTMMNAVCFENPWKTELPLDTIAISTAPFEATFRTFQAALLDQLRKNADEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WW95</accession>
    <name>A0A6G0WW95_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_011099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000140">
        <property type="protein sequence ID" value="KAF0731798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WW95"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001026"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0731798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="189" mass="21038" checksum="57F07120B67FBBDB" modified="2020-08-12" version="1">MGNQLCACCKRGEASSDDIDKLLPPRNEYVPPSTSTVQRTVLKVTHPTSPKQVHSPHHVAHSRKAEESRDEETAPALLGNDELERPRSNSGHKRVHHHTTSSHHRHQSHPPPDDTESTEANVKPERESILRDDSLNSSGSFESPRPSTDSNDPEGWTTAVSPSSKKKNKRKAKYGRANYRADSTKRTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WWQ3</accession>
    <name>A0A6G0WWQ3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_010860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000138">
        <property type="protein sequence ID" value="KAF0731907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WWQ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004920"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0731907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="27118" checksum="42F553EA7995AE51" modified="2020-08-12" version="1">MECRPRRLAALRTFAAVSRRRLVSLCRFTLTFTNPLACRMVLSEQAKQRAKACCANPKLVITYMWFIILFFAMMFCLGAIVFAANNNHDGPQYNKSLGFAGIWMMFLVVALSIGGTMVMRKFQTPIAVGFFIGVVVMMSFNMFSLCVLCAGAAYLAKLNNNGSYVETGWKGPVHSDEASAVFSFFMFALYFAFAVVLIKHRAVIIKDGASTELPEKLPPVAPQGAVSPKAAKLEEIKTTTAPPPVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WWY7</accession>
    <name>A0A6G0WWY7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_010705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000137">
        <property type="protein sequence ID" value="KAF0732052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WWY7"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0732052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="139" mass="16159" checksum="5AD24BC3D701F3F2" modified="2020-08-12" version="1">MPSLDSLSRKRQPSILCLRKYHPLLCFSISSSLEYIDIQPPRHPVVNLLRFLALEQIFVSSRSGIHVCLDLPRHFQTLCKRIDPDVDLILTQRLSLRPSRAHSEIFYPMGHLVPNIWQSPFNVFARQRVPSSPDSRWTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WXX3</accession>
    <name>A0A6G0WXX3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cystathionine gamma-synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_010632</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000135">
        <property type="protein sequence ID" value="KAF0732347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WXX3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001142"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003962">
        <property type="term" value="F:cystathionine gamma-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051750">
        <property type="entry name" value="Trans-sulfuration_enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699:SF1">
        <property type="entry name" value="CYSTATHIONINE GAMMA-SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0732347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="505" mass="55430" checksum="91D9458B946FD2D5" modified="2020-08-12" version="1">MAILRCLSAPLGDALPNDIHAVSVSMPEWKHVELYEQGCPELHASLRSGYPRFVYHAFVKAVNEWCWNKFVNDPAKLAFVLPTNTVAKRCEAFINKSFPNPLQIVSLNVCDAHALIVPLEAASCFKSYWQHSGEILSSRLANHILQSTPSSPVKGMDGTHAHAQFRSRVASMYRSVGSSDVFLYPSGMAAIFAAFRTVQQLKFSRGKIVLFGFPYLDTLKMMRRTEWSSGDVLFYPHGSDQDMEEIDQLDEIAAIFTEFPTNPLLKSADLKRLAAIAHRHNTVLVVDDTVGSYNVQVLDAGVDLVATSLTKIFTGSGTAMGGSLVVNPKSALSHVLHEHFASDSFMFEDDCVEILETSKDVADRLRRVNANASIIASRLEAHALVKTVYYPKNTETDRYTAHLTTSTEGDAFGPLMSVILHGGEATAKVFYNTLGFAKGPSLGTNFTLACPYTLLAHYDELDYVETCGVDRNLVRISIGLEDVEEIWGCFDAALNAASAMAAVAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WYU6</accession>
    <name>A0A6G0WYU6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_010116</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000128">
        <property type="protein sequence ID" value="KAF0732785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WYU6"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0732785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="144" mass="16031" checksum="EB58F580C0885FB4" modified="2020-08-12" version="1">MSALSRRFEHGAVRAQPVDLDEETQRCGGGCAGFVAPTRKCDEPDNNPSQLQAFVRHRVVPLQCRQPVVLGLSRSPIHSSWLPTLHIKHRPSSLRPPLTAVVLLESLLNLVLNFTARSKIHRLAIHRIPLPHQFSGPPLSIQTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X0M2</accession>
    <name>A0A6G0X0M2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Acyl-coenzyme A thioesterase THEM4</fullName>
            <ecNumber evidence="19">3.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Thioesterase superfamily member 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">Ae201684_009587</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28 29">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40151"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57368"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:40152"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(9Z)-octadecenoyl-CoA + H2O = (9Z)-octadecenoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40139"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:40140"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>decanoyl-CoA + H2O = decanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40059"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:27689"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:61430"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:40060"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>dodecanoyl-CoA + H2O = dodecanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30135"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18262"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57375"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:30136"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16645"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="EC" id="3.1.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:16646"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>octanoyl-CoA + H2O = octanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30143"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25646"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57386"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:30144"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>tetradecanoyl-CoA + H2O = tetradecanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40119"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30807"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:40120"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Ruffle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Mitochondrion inner membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the THEM4/THEM5 thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="28">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.2" evidence="19"/>
    <dbReference type="EMBL" id="VJMJ01000122">
        <property type="protein sequence ID" value="KAF0733337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X0M2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009131"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032587">
        <property type="term" value="C:ruffle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052365">
        <property type="entry name" value="THEM4/THEM5_acyl-CoA_thioest"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12418">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE THEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12418:SF19">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE THEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thioesterase" evidence="27">
        <location>
            <begin position="111"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00035852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00037002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00038456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00038848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00040123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00043210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00047969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00048074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00048180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="KAF0733337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="200" mass="22520" checksum="3228FE0F0C8ABF5B" modified="2020-08-12" version="1">MRGLPQRAQPLMDLILPAAEKTLLVHRPLFRSMAPVIEVPQKLLQISNDPNYTHMNVDVFKNTGFAIGASHFIHSLQGAGKYEILEVYGHNDKQFTTSVIQFGANLCGHEGVVHGGCISTVIDELFQWTAYWTTGRIGYTANLNVNYRRPLPVERPGIITAQFEKRDGRKLYMNARLEDNDGQLYTEATTLFLLPKDESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X1T7</accession>
    <name>A0A6G0X1T7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TKL protein kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_009378</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000119">
        <property type="protein sequence ID" value="KAF0733812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X1T7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010134"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05992">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13999">
        <property type="entry name" value="STKc_MAP3K-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PB1" evidence="3">
        <location>
            <begin position="340"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="455"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0733812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="719" mass="79851" checksum="39BE5EF97DEFE697" modified="2020-08-12" version="1">MWKSSSSIVGKTNGLDDLPMVLQQEINDFLHVAQGRKQQKLIPRINKVDFTKAMPDSEYIVTLQLQVVNKDYVDGWPLSSMSSIASMSLSLDRDRGKFSLAMRIPKTYPAHMPDISCVTGGEYIPAQLKRGASFVLPWIAQGWPVSYTLQQFAEDLCTALSSPEKISTTHFLAEERIFPLDQAVVANQVYPVAPGVHPSTLSNDAQSRGGFPFMGSSDGKTKTSNHGSNKKSTTPTPSSNPFDHSPHTSKQSTHMSVNQRGGDNSAGQERRVEDLINLRIAPSVADLLGFDQPTVPSSSHRADVDQLLVQVPANPVVVAGSPRGNAQSPRGLEAAYRSNECCIKCKYKDEARRFVFDRNLNFQQLQDSIKRLFQFPSSTIVTLVYLDSDGDKCGLSSDEELRAALTHFPDTLVLHADIKANEVVKNEPQPSPPTHQAQGPKHEEMSFREIKIEDVKLEKCIGVGSSCKVYKAIWRGTEVAIKKFTSQNTETVNKEFKHEVQMMIHLGCHPCIVLFLAVCTTPKCIVFEYLPFSLFEQINGSQDPSKKIPPFPNTWQKRLQMIMDVARGLQFLHSFNIVHRDLKSLNLLITDEGRVKLADFGIAKVAQDEFMTRCCGTYQWMAPEVIVSQTYSVSADIYSFGVVMWEICEASVPFADTPAALVAMAVIQENKRPTISPNIPTPLKDLISRCWDREANLRPDAATIVNALTTFLQASQSPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X2A7</accession>
    <name>A0A6G0X2A7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mitochondrial inner membrane protease ATP23</fullName>
            <ecNumber evidence="6">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_009463</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase M76 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="6"/>
    <dbReference type="EMBL" id="VJMJ01000119">
        <property type="protein sequence ID" value="KAF0733906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X2A7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001711"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019165">
        <property type="entry name" value="Peptidase_M76_ATP23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21711">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21711:SF0">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE ATP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09768">
        <property type="entry name" value="Peptidase_M76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0733906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="186" mass="21005" checksum="B491C6E365AEFDB7" modified="2020-08-12" version="1">MDIPACDAALHEALKEPRQRQLLEVINTFLKKSKKSSSDPSELEFVCLDCKAEGVEGKARAFFASPPAIVLCANRLHTNDDVKEVVVHELIHAYDYTVRNMDLTIPRILACSEVRSARESECFNTAEAMCNNPQFSMLNRGCEWYIKRCVKKNAVKATSSLFPDEADKLVHDVFDKCYADKAPFEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X2U8</accession>
    <name>A0A6G0X2U8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_009085</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000117">
        <property type="protein sequence ID" value="KAF0734223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X2U8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020306"/>
    <dbReference type="OrthoDB" id="77735at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026186168" evidence="3">
        <location>
            <begin position="21"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0734223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="168" mass="17907" checksum="6243482B6DA41E15" modified="2020-08-12" version="1">MMRSLVHALLALVLASFAYAAQDAASVTTVSTKTLNEYFKPAVPVQIDSATHIEQVNDFKSLWHLASNKGNFDVEVEEDSSNGALSLSAVYSIDEHGSKTLIYQPAGTPTNWILGAGIILIFIGVITMTSSRPSSIARAPAPVPPPSSPKGSAEATNAAIRRRRSKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X3I3</accession>
    <name>A0A6G0X3I3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_008834</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000112">
        <property type="protein sequence ID" value="KAF0734486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X3I3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000516"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007320">
        <property type="entry name" value="PDCD2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12298">
        <property type="entry name" value="PCDC2 PROGRAMMED CELL DEATH PROTEIN 2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12298:SF4">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04194">
        <property type="entry name" value="PDCD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="159"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0734486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="412" mass="46926" checksum="DE67CD5950DA89EF" modified="2020-08-12" version="1">MADDKVQVEEYGADEDALNTVNYEEEDDEDVELEGGDMEVELGFLGDKQEHLGGPFGDWDGGKVGGKPVWLNPNLHAEIKCSKCAKNMSFLLQIYCPLDEPEHAFHRSLYVFVCRTNDCPQLGHARAFRCQLPQENPFYANHQDVDYRRREAVKPLKRCAVCNLKATFSCSACHVAQYCSKEHQKDHWKHVHKEDCPRCLSLEELIVTNSSELEVNGSKFVFPEYAIHIEREPESGIAQNETEEKMMRQFQQAQSTAGTDVFTDNSVIDISQKDLSALLGSTTTQDKTYLAFLTRVALDKDQVLRYCRWNEQDAVLWVHSEGKPDEIPACSICGEPRAFEFQVMPQLLYHLKLGGEQSIEALTAVNSKELDWGTLVVYTCPNSCRRVGTDDEVDFVEEFVWRQPPFEQVEHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X3P5</accession>
    <name>A0A6G0X3P5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome-binding factor A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_008759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000111">
        <property type="protein sequence ID" value="KAF0734512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X3P5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018612"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000238">
        <property type="entry name" value="RbfA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023799">
        <property type="entry name" value="RbfA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02033">
        <property type="entry name" value="RBFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89919">
        <property type="entry name" value="Ribosome-binding factor A, RbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0734512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="34422" checksum="ABE9C180824576FA" modified="2020-08-12" version="1">MLSRAVVLLVPPSSRGFRATTVLGARRNKALSRLAIKRSVRDVQDGMKDLDLTSLQDEDADEPMVVKTTKMREALKQLNDPHSLEMDKIPLAKRGADEDMMTEEELEAFFDEDDDDDDDEDFDRELEELEHEDDKKRVRKMLTPGRAMKALTEDEKKSQKNAVPLNKEDKSRFNPDVINHRQQRVGLMLEGFIQGVIQDETDLCSGNTQVWITQVDMSPDLRRAVLHWDVTTLTHDKVSKSVEAKASRRLEKMTNFLRVRITQHLGLRYTPKLEFKRQDYGSFERRKKFDALMAAQGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X459</accession>
    <name>A0A6G0X459_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_008818</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AFG1 ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000111">
        <property type="protein sequence ID" value="KAF0734576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X459"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000531"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005654">
        <property type="entry name" value="ATPase_AFG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040713">
        <property type="entry name" value="ZapE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169:SF6">
        <property type="entry name" value="AFG1-LIKE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169">
        <property type="entry name" value="ATPASE N2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03969">
        <property type="entry name" value="AFG1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0734576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="426" mass="48448" checksum="915145B966270090" modified="2020-08-12" version="1">MRGSGVLQLYKQLVSTKALRPDPAQQTVVTYLDKLQKRLMNYDLPTNMTGPTKIPRGLYVYGPVGTGKSMLMDLFYQNLDNKKRRVHFHEFLLDVHRRIHARKQVHLEEFGRSMHIELQPERDIIGIIAKEIAAESPVLCFDEFQVIDIADAMIMRKFFGVLFQQGTVMVATSNTHPQNLYPDGVNRDYFLPFLDLLQQHTRVLAIESSTDHRRHDKPLEETYLTPLSAKTRAHIDSIVQSLLAPGAKLQLKTIPVMMGRTLQVQSSGDVCVVDFNSLCNTDRGAADYKALSEHFRTVVLTDIPQLTLAMHNQARRFITLVDELYEHRVRLVCSAAVEPDELFAFDETATGVPVPVSLAEKQTQITEMTQNHIKPFTSWDAPVAMAFDPSNDDSVKNMSSLTDMLYACKRAVSRLHEMRTLKYRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X5E0</accession>
    <name>A0A6G0X5E0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="2">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_008488</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="2"/>
    <dbReference type="EMBL" id="VJMJ01000102">
        <property type="protein sequence ID" value="KAF0735017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X5E0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000060"/>
    <dbReference type="OrthoDB" id="1158011at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23799">
        <property type="entry name" value="UBCc_UBE2J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000023">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 J2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="12">
        <location>
            <begin position="5"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0735017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="216" mass="24401" checksum="AB50FAEE406D0740" modified="2020-08-12" version="1">MASAMATKRLRKEYLALLKNPEANIEAVPLEKNILEWHYVIRGIGPYEGGYYHGKLKFPPEYPMKPPAVFMLTPNGRFQTNKRLCLSMSDYHPETWNPMWSVSSILAGLFSFMNETTPTLGSIVTTDAQKRKYAASSLEENCRDPIFVACFPELVELHKKREQAKLEAGQNAENEPSLTSENEKGFSLLRLEDLNVSIFAAFTVIVVFVAIIVLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X5G0</accession>
    <name>A0A6G0X5G0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Urease accessory protein UreD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_008405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UreD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000101">
        <property type="protein sequence ID" value="KAF0735196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X5G0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012177"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01384">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002669">
        <property type="entry name" value="UreD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33643">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33643:SF1">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01774">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0735196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="32524" checksum="8FB0D39559B2291A" modified="2020-08-12" version="1">MVDPSSPRCTGELVFEQVSSLGKTTATHEYVAYPLKFLHPSTIMPLSFPTAVTCILGYGGGLVGGDCTRMNVQVGPDATAVLCTQATTKVYKPKPTAPTHTSQEMSVTLDSNAFLALVPDPITCFDGAMYKQYQRFTVHPTASLVFIDWMTSGRHARGESWSFASYESCNQVVMEGDDAPILLDRMRLQEEAEHSLRARMGGMTVLGTVVLVGPRVKAMADALIQRGARKALKPNESPIPYGHVATNVHPNVRSAVSPLGKSGAIVRIAGRTTEEAYAFVKDLLAPLEDLVGFKCFQENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X5I4</accession>
    <name>A0A6G0X5I4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_008358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000101">
        <property type="protein sequence ID" value="KAF0735147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X5I4"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0735147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="92" mass="10216" checksum="EA1037C250B74ABC" modified="2020-08-12" version="1">MQDDECGTLLYQGKCSTLAANNAPRPPCPPPPQRQQYWPNAAHRPRHEKSNVKPHSSNTLAGNPRNHAFSRRCASSSDAAADKLDRRHATRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X5Q2</accession>
    <name>A0A6G0X5Q2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_008230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000100">
        <property type="protein sequence ID" value="KAF0735318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X5Q2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005303"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0735318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="118" mass="13167" checksum="FAC9CA261C3AE1A0" modified="2020-08-12" version="1">MDALTCELYATKAELQACRDQLESTLSEKQEKAEHVNVMVSCSNNAVDGQLKPQLEEAQEVEALATRLTSVNSQLTKKIKFAERLSGGIEDCVPRQIPRDDRQQEDGVDLVMRCQSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X6Z4</accession>
    <name>A0A6G0X6Z4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_007794</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000093">
        <property type="protein sequence ID" value="KAF0735789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X6Z4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000891"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026078139" evidence="2">
        <location>
            <begin position="22"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0735789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="228" mass="23354" checksum="305A54A80EDEC8D4" modified="2020-08-12" version="1">MGRRLLLALTMLFAMTFMSTAQIFPNPTSQCEICANAGGTGAACAQASAGLPGKYCYPWINSGVKKACCCPTAAICPTPKTTPTGCSCDTPVAAPVVVKKKTPVWVWIVVAIAVILLAIAIWWFCCNTTTVVEEPVIVEQPVYVHQPGVVYQQQPGVVYQQPVVYQQGYTGGEVAAGVAAGAAVGMIGGVALGVALADHGDGGHYVVEGGYGGGGYDNGGGGDFAGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X7W7</accession>
    <name>A0A6G0X7W7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_007653</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000090">
        <property type="protein sequence ID" value="KAF0736066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X7W7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003536"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0736066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="32855" checksum="6E431621024BB297" modified="2020-08-12" version="1">MKTLLHKKPRLNAKLSSEDWQECKLAVSASLRAAGIHAIADRQYTRLDTALINAGLFGVKHNYSCVRPKTNSQGKRISVEHIHSVKLDAPREAVVRAIWSFLKEPHLQSPLPSDAHRVIEIVDQNTLYEMYKERSPAGVFCHSNIIRKLYAERHRHVILSRTVLHDALAPHMVQGDVEDESSWIVVEDNEVNPQQCHLVILVQVQNDLSMLASPMQLDEDRIAEHLSKLMLRAMPDGRGLISPEVNGVDWNDFPTTMATFTQIGKRFEEYMIQGINEAVSNFKASQVSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X8C3</accession>
    <name>A0A6G0X8C3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_007206</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X8C3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009023"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="266"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0736183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="422" mass="47049" checksum="B64C97889EC964CF" modified="2020-08-12" version="1">MKLPLPPGFFTTPPLSPHESNEFIEQAYACALDVIDKARLTGGQLLWTQHADDAAGLKIFKGHDIVHESIKYCLAVTEVEGTLDEAAALFATDTSEQLKAYTDRFGKGLLDAAQLYTLVPRSDKAPLEKVSINWTALQSPVGKLTSHRDMCLLECQHAFESGSKQGWVRALKSVNVGCCPDLKMTLGLVRHVIYGTGHVFVESSAPGYLQVFYLIQTERTHGKSRDWAFDMAMKRRCKSLLDLDQFLRENRLSRGSFLPSELLMPKHHRRNCFLCKKKLWPFSGKFNCVKCGEVLCAWCCTLWTVQIHGEMRQIRACSACAQATMKKRNPLRTSRPRRSVQILVTQDTQSSYMDSIKSAPAELSGLREPTEMSNCSVADVHQALASLRCFYMPEYDPIVLHDDEDGGGGSGAPQPSPSSRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X8M7</accession>
    <name>A0A6G0X8M7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_007420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X8M7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007085"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007104"/>
    <dbReference type="OrthoDB" id="67309at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0736401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="191" mass="21788" checksum="A4042D4D422080DF" modified="2020-08-12" version="1">MEGYLIHHSSKKPSKVRYCRLEHGYLRFYASHETSAKQTEEFRLSGCKVDVKAQARTDKIPFSFFVEAQRVLVKDRSYALAPKEIVEMSAGSPEGRSAWGKAILTWQRRYFQEEDAMTEIQHEHERLRLEEALHVYQRPAPAASTSTTPTQGFRMGSLRKSISSMLESLTSRAKVDDTCFDSHPPHPVAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X8W1</accession>
    <name>A0A6G0X8W1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alpha-ketoglutarate-dependent dioxygenase AlkB-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_007518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X8W1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020094"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032870">
        <property type="entry name" value="ALKBH7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21052:SF0">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21052">
        <property type="entry name" value="SPERMATOGENESIS ASSOCIATED 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-ketoglutarate-dependent dioxygenase AlkB-like" evidence="1">
        <location>
            <begin position="136"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0736508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="231" mass="26692" checksum="B9F4F302C33C067D" modified="2020-08-12" version="1">MLARLSCSRRRVSSRLSRLGARSYSSSYSWLESHLIDRSMCRDESLASNDLQVMEDVITCEEETLLANEASAQLRRRRYEVNHWDQVIINFKEMETIKWSSEAQQVLARVRALPIIPQDLEYFPAVHVIDLAEEGYIKPHVDSIKFSGQIVAGLNLLSPAVMRFQEENGESRIDLKLPRRSFYCMRGGVRYRYTHEILPGVQTFQGEAIQRTRRISIMIRDVFVPPATSQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X9F4</accession>
    <name>A0A6G0X9F4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Class II aldolase/adducin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_007152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000088">
        <property type="protein sequence ID" value="KAF0736705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X9F4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010796"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005451">
        <property type="entry name" value="PRK07044.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF3">
        <property type="entry name" value="PROTEIN HU-LI TAI SHAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="1">
        <location>
            <begin position="19"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0736705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="261" mass="28801" checksum="FCB1C00C033121C6" modified="2020-08-12" version="1">MGRNDLPAPVSDEEWALRVELAAAYRLFHQFGWDEVIYGHLTCRVPNDTDDYDVKNAHFLINPLGIRYDEMTASKLVTIDIHGNYINRGSTGLDINQAGYVVHSSIHEARHDMRCVMHCHTVEGTAVASMKFGLLPISQLSHVALSGGVSYHDYEGLAVSEAEKPRLKADLGPDNLVYILRNHGLLTGGRTIAEAFFFMYYTVHACKIQVAALSAGIENVSYASEEVATHFKKGLAPFVKAGVGKEMFDALKRGLSPEYAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X9S9</accession>
    <name>A0A6G0X9S9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_006949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000087">
        <property type="protein sequence ID" value="KAF0736790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X9S9"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0736790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="117" mass="13070" checksum="1F260408DEFC2684" modified="2020-08-12" version="1">MGQNTDIIRSLWFYTRSLQRRLGRSRIGFLHVRSLHCVRVKILNGVCPDKIPISSVRFGSTRARFSAGLGEVASAINTVCLDVLSFASPDKITEVSQAMSSRQDTNDNVARLRPQSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XB68</accession>
    <name>A0A6G0XB68_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_006552</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XB68"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021753"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0737387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="28966" checksum="1075C0FF578C43B3" modified="2020-08-12" version="1">MTDHRRRSERKKHSNRGSSLASLNITKLLSADQTAFKQCRTHGAYVKNFAGHMKIQMGFFGRWKQCFFTLQGVELTMAEDEGYPALRSDTIAYVVILREKEDMLEFHMKSKKIWKTQCISRDIANAWFSAVDDSIGRVSYDLTRYFKSCDKRQIPTIMCGWLSEMDGKRVVARYFYVLRHLTLSVAPNIDITPEVYDVVTGLTAAAQDGAMKFMFESRPPLILRSDSPELLQIWHVVVRTCMNEPRRAIYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XBB3</accession>
    <name>A0A6G0XBB3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphatidylinositol-3-phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_006527</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XBB3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021728"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14507">
        <property type="entry name" value="PTP-MTM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF128">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3,5-BISPHOSPHATE 3-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="4">
        <location>
            <begin position="1"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Myotubularin phosphatase" evidence="5">
        <location>
            <begin position="577"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="2">
        <location>
            <position position="794"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="731"/>
            <end position="732"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="794"/>
            <end position="800"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0737358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="974" mass="111608" checksum="B101847393353BDB" modified="2020-08-12" version="1">MRFLRVSSEGDLSHERKSYETLRDQLKFRPTSEQQHHPLSEAEDNPWNQFFEDDQLVREINTDLDRLYPQGQEMYFQERKHYMDMLRNALFVWCKQNPTLSYRQGMHDLVAVILYAFVSVEAEQNVTSDFTEHDTYIVFQRLMLWMGPLYAIQTIPSSDDTDESASIPTEPTFPQPVVEERLFRPTNGPDNEPNILPAQSKLQLLCHVIQYELLAKHDPQLACHLQNIQILPETYCLRWLRLLLAREFALDQALRVWDALLEHSHMQESPAELTLLPYLCVAILVHFSATLRSQDNTGCLQLLMHPLSSLHAQTIIDSAVLMENPMKENTHPDMDVACFQDGSLGIVLTNAKSPYDHRLAVKEFSGQALESGKVQLGDLIESINGVKMYKISTDDIKKHIALLPRPIYVSFLHVIDSIPQEHEANDPTIAPPDDLPPFFDGEQCYAHVETSMHQPIFHAPSGSCMSHFVSGRLFLTSYRCLFQSTTGILWEIPILSIASIVGDTVPLDANPLVMVPRDTAQHTVVLQCKDTQRAKFAFRDQQEFSRMYKCLSVLAFPASLTDAFCFHYRPHILPSDLVAPFDIRLDYQRLGLLNGPRFRCIDQAYLLCETYPRYVIVPVGMSDMKLQVAAQFRSSQRLPVVSWQHPTNQAVIARSSQPLVGLKSTRCAEDEQLVQMLCSGSGDKGYHSNFRYVIMDARGQLAAAGNKAMGKGTESTANYRGAKVVFMNMENIHAVRNSFQNLSNAFDPMDSDQNTSFFQKIESSGWLKHVRLALKASWELADYVHSGVSVLTHCSDGWDRTPQMISLAELMLDPFYRTIEGFQVLIEKEWCSFGHQFGLRSGHARSDVSNDQRSPIFLLWLDCVWQLMRQFETEWEFTPSLLLFLADHVYSCKYGNFMFDTEKTRLDCFAKYNATNIWSDVEAKRDTFSNPRFSPERTFLTPSTAWKNIQLWKGYFARFDPTFVPPVECLQFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XCF8</accession>
    <name>A0A6G0XCF8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein-lysine N-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_006376</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000083">
        <property type="protein sequence ID" value="KAF0737712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XCF8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004982"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019369">
        <property type="entry name" value="Efm5/EEF1AKMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041370">
        <property type="entry name" value="Mlase_EEF1AKMT1/ZCCHC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13200">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13200:SF0">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10237">
        <property type="entry name" value="N6-adenineMlase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0737712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="219" mass="24914" checksum="595F5A254552BA2D" modified="2020-08-12" version="1">MPNLDALLASELSAETLAALHAHLAAVNTEESTDISEDFRLSQFWYDDKTGETLAREALEKSKGGPIAFLSTPAAFKALKKLEPERKDVYIFEYDHRFGDKYPDEFVFYDYIAPLAVDSKFHGFFDYVLVEPPYLTEQCLKGFGETMRLISRELKKTASGKQVMATPNVFINTGNLRDVMREELGLEPSGFVPTFESKLSNRLTTYINYDSERFGPYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XCN6</accession>
    <name>A0A6G0XCN6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Microsomal glutathione S-transferase 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_005921</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0737925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XCN6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020016"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006691">
        <property type="term" value="P:leukotriene metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050997">
        <property type="entry name" value="MAPEG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10250:SF26">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10250">
        <property type="entry name" value="MICROSOMAL GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0737925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="131" mass="14662" checksum="6168F17172B84D17" modified="2020-08-12" version="1">MAFVPPSIQADHGYVILVIVLTAFVNFWAGMKVGAARKKYNIKYPQMYAEKGDKNCIEFNCVQRAHQNMVENLAVFLSLLVASSIYRPMWAAVAGLIRVLGFIVYVISYSSGVPEKRLYGSFGMELTTIFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XCR6</accession>
    <name>A0A6G0XCR6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_005951</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0737955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XCR6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017952"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010463">
        <property type="entry name" value="DUF1057"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47533:SF4">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47533">
        <property type="entry name" value="PROTEIN CBG21859"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06342">
        <property type="entry name" value="DUF1057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0737955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="31871" checksum="90ACE59CA371C5F1" modified="2020-08-12" version="1">MADKAVDKVTLSNGHDFWFAMYGDADALNSYILVHGAAGTHEDFEYLSPLLVRENFNAIAVDLPGSGLTPSRAAGGNKLTEDLVVEAMCDFVGILASRDPCRRFYFVGHSFGGWTLIQVAARGKFVSLVGLCLINSSGFRPHVAVRPFWFNHFLYQLLVLSSVTRFVMADVVHFVSIKFIGFSPNLTKKDAVSMFHRGATMDYKGMKDCAAFINNAKIPVLHASALNDKLLEKAIGDEICAVLKPDVKIEFDRGGHKIQKTKAPELAEAIVEWATSIMKSQPNEIRSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XD46</accession>
    <name>A0A6G0XD46_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_006076</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0738085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XD46"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013218"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47692">
        <property type="entry name" value="RING/U-BOX SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47692:SF2">
        <property type="entry name" value="ZINC FINGER RING-TYPE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="64"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0738085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="266" mass="30749" checksum="2BFE4158D975A6AC" modified="2020-08-12" version="1">MDELEVDAWKTNCLDGKDEVTVEEIQVREALDRDSNESRSEDGEDGALTSYDVEKEYTIVHGKCPVCLKSLDQGVLVKDCLHEFCFACISAWARHLALHRAPVKCPICRLPFQNVLANLKSATDYDVVDVLDGSTQASTEERKRRMIYRRRQEPVVPETTTMWDPVWKTNDQAKEWIDRELHVLLGDDTDTTLLLQIVFKFLDQARHFNRATHETKRQKTSHPYESLREALDGFLFEDSALFVRELSKFMASRLNMVTYDKVDETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XEV0</accession>
    <name>A0A6G0XEV0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">deoxyribose-phosphate aldolase</fullName>
            <ecNumber evidence="2">4.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">2-deoxy-D-ribose 5-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_005395</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde</text>
            <dbReference type="Rhea" id="RHEA:12821"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="4.1.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.4" evidence="2"/>
    <dbReference type="EMBL" id="VJMJ01000070">
        <property type="protein sequence ID" value="KAF0738783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XEV0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017548"/>
    <dbReference type="OrthoDB" id="70823at2759"/>
    <dbReference type="UniPathway" id="UPA00002">
        <property type="reaction ID" value="UER00468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046386">
        <property type="term" value="P:deoxyribose phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00959">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000044">
        <property type="entry name" value="Deoxyribose-phosphate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00114">
        <property type="entry name" value="DeoC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011343">
        <property type="entry name" value="DeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028581">
        <property type="entry name" value="DeoC_typeI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00126">
        <property type="entry name" value="deoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889">
        <property type="entry name" value="DEOXYRIBOSE-PHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889:SF1">
        <property type="entry name" value="DEOXYRIBOSE-PHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0704">Schiff base</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="12">
        <location>
            <begin position="3"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0738783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="317" mass="34759" checksum="A027FD80B1C0A639" modified="2020-08-12" version="1">MGRKRGAVWNEFTELPESDDPQMKMPRVECKHCKTSLSKSSSRAVSHLRACPKFVGDLPDANDNEDRHTDPFAPHIPFIREDNGKKYHPVSRMIDHTLLKADATADDIAVLCREAVENCFHSVCVNGIYASHARQVLQAYETKRNKPRQVKVCCVVGFPLGASTSEVKAFEASQYIEDGADEIDMVIAIGKLKSGDHAYVVRDISAVVSVCKRKSVLCKAILETALLTENEIETASRLAISAGVDFIKTSTGFSSRGASVHDVMTMTRLARPHNIQVKASGGIRTEDDAEEMIQAGATRLGTSAGLVITKRDRMSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XH02</accession>
    <name>A0A6G0XH02_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Striatin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_004719</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat striatin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000063">
        <property type="protein sequence ID" value="KAF0739537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XH02"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010552"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013258">
        <property type="entry name" value="Striatin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051488">
        <property type="entry name" value="WD_repeat_striatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653:SF0">
        <property type="entry name" value="CONNECTOR OF KINASE TO AP-1, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653">
        <property type="entry name" value="STRIATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08232">
        <property type="entry name" value="Striatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Striatin N-terminal" evidence="8">
        <location>
            <begin position="7"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="208"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="320"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="472"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="71"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="111"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="138"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="177"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0739537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="550" mass="60086" checksum="9A85AA2A66E34ED4" modified="2020-08-12" version="1">MESVEEALKYLGKQFESAEVARIQWQEEKKQFQAQLVELQAQKKIQDDYAKELVLQVKMLEFALQQERGRYVASMPSTKDKAITRSERANTSPFDSPRSGKEQTVFRRDSANNNSGLYTSSPNVSSKHLDGKGDSEVSRTNGMEISRNDVSVTRSKEGETLISRPRVSSKADKTGVVPPPPPPKGPPPVEVTTKVNSNFRACKMKLKLSGHLDGVRSICFHPTDPFLVSGSEDCTVKIWNLATKNSEVEPLATLRLHTDSVLSVAAIKPEQSSGLGFRNGLIATGSKDGTIGLVAFPEVSDKPIEPFAFDDYYKFLVHRMEAHRDAIWSLHAHPYTNLLFSASADACVRVWGIAAEPTLKCTLGASVRQHPAGLGHNVDGLLVPTCISAVPTNAATCIAGYTSCTIGQYDISSERLLQLIVPPESDVRITAFREAQINHIVAHPTMPLVIAAHQDRRIRFYDLRAGQCVASVVAHQEAVSSLALDSSGLYLASGGHDGSLRFWSVAERTCVHEQSAHRPKFAEAVHSVAYHATRGFVATAGADSVIKVFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XH08</accession>
    <name>A0A6G0XH08_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_005038</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000064">
        <property type="protein sequence ID" value="KAF0739473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XH08"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014381"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13983">
        <property type="entry name" value="STKc_WNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001565">
        <property type="entry name" value="WNK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000427">
        <property type="entry name" value="Wnk protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050588">
        <property type="entry name" value="WNK_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13902">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE WNK WITH NO LYSINE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="17"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="668"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="760"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="670"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="786"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0739473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="824" mass="90893" checksum="AAF316FABA6FD142" modified="2020-08-12" version="1">MDDGDKAVEQSPRGIYIRFEKKLGTGAYKTVYKAYDVDQGIDVAWNAIDIGALPHGEKARIIQEVELLKKLEHKNIINFYGSWFAKEKNQVVFITEVMTAGSLKSYIKRVHFIKWKIIKRWCLQILEGLNYLHSQKPPVIHRDLKCDNIFINGNTGDLRIGDLGLSTQLAVENRRAQSVLGTPEFMAPELYDENYDEKVDIYAFGMCVLEMVTKEVPYSECANPAQIYKKVVAGIRPQGLSRIKSQAAKDFIELCLSRGNGKVDVTASYLMTHPFLQPSTDDDEMVECIDPNAPAATPLSPAHNSLKEMDHEESGTTRLDRRRHSSPPVPQFDLIRSPLQAPALAPPLPEEPTIKLEEPKNNPLVFRNRPTTDAPLSAGVITANDKAADAILASMKDTEMNHDDRKAVMDGRNNPMPAKQKFNLRDPTDPGKPPPAVSDSPVLKPRLVDSQRKNSISDGAIPQAPNSAPTPLSQLPPIAPSLVKKSSSGDPIGGIVPPPPPPPVGTPNAGPIRKRGRRHEIKATKDPSAPHTILLSLRIILDGKSKEIKFPFNLFTDSAHDVACELAEDVAILEPDVGDIADSIGFLATEGKQVNLPEVDVDVWEEAPEPHSFSSKPLPHVSKMNLIPHMNGFLDLDQPFDDSTSGGTSFLSTSSSSSRDPYSLAMDETVMSSGPNSLSKQSSLQDDMEWPSTSAPHSPLQVPQAQINHTIVKDHGEFHIEQAIRDEKEKHEKELEKHEQEMEKYRRKIEEIQIKKQAVLDKKQQLQGDADVPTPAEEKPPVAQQPSLSSTPPSSTTTPSPDDDSLRKQRPLYPSAPPVAVAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XH26</accession>
    <name>A0A6G0XH26_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Heat shock protein 75 kDa, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">TNFR-associated protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Tumor necrosis factor type 1 receptor-associated protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">Ae201684_004949</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Binds to the intracellular domain of tumor necrosis factor type 1 receptor. Binds to RB1. Interacts with SRC. Interacts with SDHA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000064">
        <property type="protein sequence ID" value="KAF0739380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XH26"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005707"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16927">
        <property type="entry name" value="HATPase_Hsp90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.790:FF:000004">
        <property type="entry name" value="Heat shock protein 75 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.80:FF:000004">
        <property type="entry name" value="Heat shock protein 75 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000021">
        <property type="entry name" value="Heat shock protein 75 kDa, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11260:FF:000004">
        <property type="entry name" value="Heat shock protein 75 mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003555">
        <property type="entry name" value="PRK05218.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0143">Chaperone</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="binding site" evidence="18">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="154"/>
            <end position="155"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="382"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00066161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00073018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00076190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00080766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR002583-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF0739380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="677" mass="75609" checksum="CE915E346FCF6B55" modified="2020-08-12" version="1">MIRLSLQRAAAAAIAAKSVPRLQSRAARAVSALALPTKTFAKPSYAFRAFSTEPSSTGDRHEFQAETRQLLDIVTHSIYTDKEVFVRELISNASDALEKFRHHQAVGSSLLTPEIEPKIIITTDTTNNTLTIEDTGVGMSKEELIQNLGTIARSGSKAFMEQLKKEAPTETTAAATGIIGKFGVGFYSAFMVADKVEVYSASALGDGSGHVWSSDGSGSFEVRAVENVGRGSKIVMHMKEACKDYAKPERVESIIKKYSNFVAFPIVLNGTEVNVVQALWTKDAKDVTDEQYTEFYKFIANAFDDPLYRLHFKADAPIELKTLFFIGSTHTEKFGYARLEPGVSLYSRKVLIERHSPDILPDWMRFVRGVVDSEDLPLSLSREKMQDSRLLAKMKDVLTRRILKFLDDQARKEPEKFDEFFKEFGQFIKEGVCMDFQNKAGLSKLLRYESTALDEGKTTSLDEYVSRSSPDQNEIYYLCAPSRELALQSPYYEAFKKTKKEVLLVYHSMDDFVMNSVGEFNGRKVVSAEAAKLDVQEEDASGEKLSDEDANLLTAWLGLKLEDKVSSVSVTNRLHDSPAVVTDHESASVRRMMQMVNQNQGGFAMPSAKHVLQINPRHPIIVKLNKLRTDNEELAEKIAKQIHTNSALSAGLIDDGRVMLGDLNFLLDELLTHSLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XIC9</accession>
    <name>A0A6G0XIC9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial import inner membrane translocase subunit TIM22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_004596</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the TIM22 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion inner membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000059">
        <property type="protein sequence ID" value="KAF0739850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XIC9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011390"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042721">
        <property type="term" value="C:TIM22 mitochondrial import inner membrane insertion complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039175">
        <property type="entry name" value="TIM22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0739850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="188" mass="20054" checksum="0DA5B34FAE970E32" modified="2020-08-12" version="1">MDNNDAASGRSPFILPYSHNPFVFPYKPSGNDVGKEVPTFYPVYPGETCVSKVILSGAVGYTLGVIMGGLLSSYEAIAPPIPVPGQRVLPKVPFREQMQMSRRLIAEKSRSWGRNFLIFSAMTSGLECLVSKGRGRHDTTSVALAGCATGATLAMGQGPAVQCGSCVLLAAFSAAMEQFMHGDSYRNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XIR6</accession>
    <name>A0A6G0XIR6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_004418</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000054">
        <property type="protein sequence ID" value="KAF0740187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XIR6"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0740187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="343" mass="38331" checksum="B2AC35EF10F1A77F" modified="2020-08-12" version="1">METLSTAWTAFVQVDAIVFRCVRVHSSSSKQLEGKQEKVLHGELIAASLSEVVLITVNGASAPNASKADLSYRYVGMARRIVRVGKDADNTINADHVGVGLSGRYSDYPWKGLLSFSDLVLGVLFPFQSSNFIIDFVDDFRVQGGDFVDRRVLRGAGLFQQRDEFLQFFNAFNGILDFSAQTVVGRLQVGFQAAAFRVAVARLNVREFEVVVVVFQRINQILVLNQLSVVGKVDRFRFTLVQKTFSQNVVMGLLQAVQRLTSASIAELGTQRFPVRAQRNRGGRAELAARVLDNHTQGVHSLDKSSRKRRNDYSGIYSHPQTNRTFLNLSRQTVYNHSIIIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJW9</accession>
    <name>A0A6G0XJW9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ae201684_003956</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the amino acid/polyamine transporter 2 family. SLC38A9 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000048">
        <property type="protein sequence ID" value="KAF0740579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010253"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF244">
        <property type="entry name" value="NEUTRAL AMINO ACID TRANSPORTER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0458">Lysosome</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="16">
        <location>
            <begin position="112"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF0740579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1730" mass="194806" checksum="C60EC489329A6E3E" modified="2020-08-12" version="1">MKYNLIKQDSADEPLLREEERLERGLPARWKLRRITYLGFKVTFFRCLDKEWMALSANDRRQQQSAEEPHDDAAEGTQSALMPRRVAHLSPLDSSVGIKDDASPPRTFQNAFVTVLSLWNAMASAVVVGLPYGFSCSGKFPSIAPRLDGAGILLGIGLVLLVGLLCWYTCALIVREDSTDFGRLMGRRLQVAAVALSALVLLSACISFHVLMKHSAHAILFAIFEWRGIDTKWTPSQAALLVCLLFPLTLFKNVAALVRLNACGVIFLLFTVYFIASHGIQAIATHQPMDDVDFGAKASCGVLGGIVTQSFFIHHAIQPMVRSSNPSTRSRDVALAYLLVGLTCVAVGVLGYIGFPKGRIEPNFMDAFPATDVVACAARLSFLLQLAAVYPLFVAVIRTQIFSLTLQNPWPSLSRVLALNVLVMTTTTLFAVFYPDVVDILRLLGAVGGFVLIFGAPIAMQSLSRGRWWPRVLCHAAVVGSGLTLLVLEIDVQKRAVFHVMGSTDEDAHPLTALHDDAKAHAIKAVQLSKSGDYHGAIAALDSAIQVDGDNAILWKHLAIAHYELWKRATSATATLASTSFLAKHSNGTTDPLELLLRNAYDVFIVAMEYVENKHDPALLLQLAALYVELGGFQGALSLCTLVLETTRPASFPRFNQAVFLAAVVAHGLRHATQAGEYFAYLLDMPPHSLRSYQLVVLAAMQFDGQTDSNEALQRGRVLYAEAYRRLTCGAFESTSPSEQRAMDAYRTSRKSENERILQWMADANLWESLGAALCRLNYPTLATAVFEYAINRGGCTTKELLVDVGRVCHRLKQSERAQSFLERALQFDYFDFPTRFWLGVASAPWKLHFARENFAAKSFQRVYRGHQGRRRVQFLRHRRACRLLAKVRSVAAIFLHGRSAKTRVAIRKALELEREAAARQAMHDQDAFLVYLKWNAAARKIQSLLPIHRAKVEKHRRRMWMEKHKALLRRVVSNSNARLVQTCFASIVEFVAMLRDDKRSASLVLQRAVRSWLCRRQLDRLRRKRAQQQTLVDTFLGKTAARWKNDCFAAWKRFLAALQAQYNHSAIRIQSAFRAHQARRLFRLKLERQLRVRRFMEALLLHRKSVALRQCFNALATLAIAARLRKLAAATKIQKIVRGRQARVRAAKLRRRRQYCDKMVQRAVAERRKRLVEQLWSSWQLYLQVSALEKQSAATAIQRVFRGRAVRRWLRRRRDYLRVYFGHRPCRENDESAATWTRLLFVAIATSRQFRMERQDVSARVLQRAWRHAKSRRLAKTLRDKLLGQRRAAHVFQTTFHMAAAAFFQQLRRLRLETQLKKHQAARLLQRNLRGWLARRVFKRMAAQHRQAKALLDRVIHRKELYWKRVVLQLWKEWLEEHHEESVAACIRIQRLFRARQAMKLARRQMDKLARQQRLLDQGWAKPLARAFRLWQQAAVDRMSDVFRANVANKYTKSFGEKELPPPPPSIQDVRSTAVPSMLFYHVLTRTRQSGVCHLPVGHGFDLPQLRQLFQLATSVISDAGGVASQVADALAWLGASPVQKLILYNEPTVNLVKLARCLDSSSHCLTSLVLGGAFLSTRHVTALALALAQPTAKLQQLVLDSCHIGNGGAVVLALGLVQNRSVWKFDVSSNHIGDGACRALGEMLLGNETLQIVCLNGNAISDTAALTYLEPAVANLPSASALTSLHLHNNPKLTSRGLTALARAVESVNSKRPTTTTAVLRLEPSSFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XKT0</accession>
    <name>A0A6G0XKT0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_003830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000042">
        <property type="protein sequence ID" value="KAF0740946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XKT0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016197"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0740946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="465" mass="52600" checksum="1A0D140D67D2EC0D" modified="2020-08-12" version="1">MLPRRTTLSPADEMEMPHILLHKLQAGEPRKPNRSKRRRQHDVQDDIQRPPTPPAPHILDPAAEDAVLSLLALRQNAPSTRRRSEVEHKSLISPLESQAKQTNHAMSFILNAGHEQNGVRLPKLMLSRQQSPLEDASSPIPRNTAYGSRAATFGGFKPRGNSTDETARLVLQDQLDQLHQLRQGSTQPRESSRQALPGDEDEEDDDDEDDDDDDDHGSESSCDPLRLSMAGADSAVYRRLLASRQVPVQTSKKNFSTSWAQRKHNFELLQLTAQLEESRRNYLAYVRRALDDMRDDMDMARRRTQARFASMSYLFQTMTTDGYEIGAFTYNHAITSNAFAESIRDFRGLFGALSQAGVLHKCSIDGVENLEGDGAGVVFHCSFQVTMGMMENGMMFHSRHQVGHLQALLRPELHWVIPHLLHTRHVWTVNATLHCFYHTFDIKNMYIHVDLDHALRTLSSVSPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XLK5</accession>
    <name>A0A6G0XLK5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_003443</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000037">
        <property type="protein sequence ID" value="KAF0741331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XLK5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016732"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00083">
        <property type="entry name" value="bHLH_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="20"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0741331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="214" mass="23782" checksum="D71EA28345657113" modified="2020-08-12" version="1">MWVGQNDDDAAASTGKSTSSNRAELNLKEKQRMLKLNATIDNLRKELDNAGVSSKMNKQSILDNTIYYITNLQNDVVIAKQKAEYAQRIAPPSAATISPFERYFEMSSTPKLIITLDIQLVRANHAFRVMSGYTEDALRHKETLLACLSVDTSRVRNMVLNAIDSKKPVQTVVENAFATARLMNCLVFTAIFDAEGTTPECIEVVVTPLHRATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XM68</accession>
    <name>A0A6G0XM68_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M13 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_003195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000036">
        <property type="protein sequence ID" value="KAF0741510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XM68"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000404"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="2">
        <location>
            <begin position="2"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0741510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="293" mass="32899" checksum="60A142A9744EFD47" modified="2020-08-12" version="1">MLYVKGDDRDATMNTLFALQSPLPLTSKERYLDENLWSTIEADYKMYISTLFKLVGRSPEEASDAAMKTIGFEKTLARSMLSTLESLLVQASREDYFPFSLFDAATRFPLSVGPLLDTFGLNTTGTEPITPGNRIVFYDLSYFDKIEALLHATSLDDLKTVIEYRLLQVSAPYLSSHFEKAHWAFFEQKLKGKTSPPSRASKCTEDAGGQATKESPGGLLHDLLGAYYLKERWPTERADKSMEYVQELTASAKASIQNADWVDEWTRTNALNKLAKIDFQLGGPGMPQLYPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XMV6</accession>
    <name>A0A6G0XMV6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Crinkler effector protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_002997</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Host cell</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000034">
        <property type="protein sequence ID" value="KAF0741804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XMV6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015473"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043657">
        <property type="term" value="C:host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045379">
        <property type="entry name" value="Crinkler_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20147">
        <property type="entry name" value="Crinkler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Crinkler effector protein N-terminal" evidence="4">
        <location>
            <begin position="2"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0741804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="644" mass="73141" checksum="DAC7FA0CDB2E0B9F" modified="2020-08-12" version="1">MLKLFCVVVGHEGSPFSVNVPADETVDDLKKKINDEMKRLPAASELQLYRVDGLSQDDNEQIVYNGTTIDMPNCSLVDFGSSTKKMAALSWISESFIEADVNIRWKIHLLVVVPSVQDQSSKSSDAEPLLKKVKITQPYVVCQGPVGVDFYSVPMETIPAYRKLSALYSAEGAQLCMLYGPRQFGKTTIGCRIQDSFANDTSVFVVYHSATELSVATEEAFWMALGQLCGEVASTPQELMKIIIRRKQRLFLIVDEMDGMFVNSVLTSHFLDILREWLRSPHFRGFLGIGSYDLVSLYKHHKGNDRVSPFNLATIVKSDRFSADQMIAFFKLIEPRYPFTDSTRYAIMEYSGGAPGVFGSLIQFSIDNVKWKVERHQWETWLKITTFFEYLEKYNFTYSRIRDDLQKLSTEAWKTLEALLMNGASIHRSSVGADILLRMGIVFEGTDSTVVFSSEMMRRVCLEALPIRDIKQALCSDNPFELFAAALQFLKPKTITHYLVTNRQSPSEAVFQFELYSSIRGILTSNNETRHILAEAGECDDRRRLDIIICNGVKYGFELKSNQLTATTITAAVKQADGYRTLLAIDKMFMINFVPQSHSMDEICQVDKFPYVEIIHVRFPESCTIYEMRFQGLSKIESRFVSCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XNB5</accession>
    <name>A0A6G0XNB5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_002912</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000032">
        <property type="protein sequence ID" value="KAF0741971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XNB5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017401"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034338">
        <property type="term" value="F:short-chain carboxylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000952">
        <property type="entry name" value="AB_hydrolase_4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050960">
        <property type="entry name" value="AB_hydrolase_4_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012020">
        <property type="entry name" value="ABHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794">
        <property type="entry name" value="ABHYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794:SF84">
        <property type="entry name" value="ESTERASE_LIPASE_THIOESTERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005211">
        <property type="entry name" value="Ab_hydro_YheT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01133">
        <property type="entry name" value="UPF0017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="401"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="6">
        <location>
            <begin position="102"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR005211-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0741971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="428" mass="47971" checksum="8C27C213BEC85E40" modified="2020-08-12" version="1">MVWRTLHALHPAVAAVRPSLVYKATPDNEAIIDKCPALDGHFHPTWFLFNGHLQTVRVGRGGRAPSVSYKRQLVRMSNGGTVSIDWAIPPGCTDLGYEHDHPTIIMLHGLAGDSQNNYIRSAATKLLRDGWRVVVMNARGCGNTPVTSPQFLSASFTEDIREVVALLRKDYVPTAPLVGVGFSMGSNVLVKFVGEEGASCLLTEAASIGNVFDLNNNLKHMNTLFYYYLYNISISKTIIRLFFQKQFENEPGIDIDHVRAAKTAWQFDDRLTRHVLGYASVEEYYRDASSRHYIPRVRIPLLCLSALDDPVCTHTSIPYRECADNERVILATTARGGHLGYYTSDSFWAQPDMWSSTVAAQYCKAIVVEQVWRDRLQAFATTSAPSSTEDVNKERRFLFDLRIMLACFMLYVATIFAGFNEISLTIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XP36</accession>
    <name>A0A6G0XP36_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UV excision repair protein RAD23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_002678</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000029">
        <property type="protein sequence ID" value="KAF0742274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XP36"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009402"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14281">
        <property type="entry name" value="UBA2_Rad23_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621">
        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621:SF0">
        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="25"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="115"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="244"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0742274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="291" mass="32051" checksum="40DE1266A0285C61" modified="2020-08-12" version="1">MGRSITVVVIGTLPGQPSKNGGKKRSLEQTQSNILHLEMQIQVELAWSVQRLKEEIASTLDRELQSSVDIPPENQYIAINGSVVCDADSVGSVLLDKRTIVCAIDATQENAPSRETTEQSVAVHALERMGFSTKRAKEALDISNNNVEAAVAFLTDGIYIDTSTQRKTDDRLADIAMNKPYYLFTALQSCDPDHLVDMTLDRMSAAMQRQQSKQEVDEIDTADEEETKEEMSPAAELVYNEADFLQEHLAAAAIERLQALGFGREEAYNAYAACGRDENAAANLLLESFAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XP38</accession>
    <name>A0A6G0XP38_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_002851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000030">
        <property type="protein sequence ID" value="KAF0742184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XP38"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000773"/>
    <dbReference type="OrthoDB" id="10271703at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0742184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="69" mass="7552" checksum="97471ACD7A18E46D" modified="2020-08-12" version="1">MSDVTGNTDGYYWMIIVFVLCLAGCAGYYVYKQKTARLEDGGRYTLSDDHVESGVVAQRAAPAPESKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XPU5</accession>
    <name>A0A6G0XPU5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_002637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000027">
        <property type="protein sequence ID" value="KAF0742546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XPU5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001260"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0742546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="468" mass="53257" checksum="57F32598FDD58E93" modified="2020-08-12" version="1">MNRGKDTHFRNGFDVIQDHVKLSNNRLRKARRNAGKPDEATLDQAEGNQELDESTISALASYLQDKAIEASRRNAPDFTTANRPNHRASSRVVYGLAVKLNNMTKLRGYKRRSGLKFTCAASPRGSNDKLTKRDSKNFREVQVATMLHRQRHGNPLELSEKVLSAFRAVAHLWLQRKQRREQAVKDNVTSKMVMGRRPSTTMSNNVFDIISKSFVTAVPALQFFDDSTDSTTQRAQQLPSNQTIPRGICYTMSEDGTRQCKTQHNMSDLAHVRGWTREKDANKTVCLDDALLLSMNKRLKIRMALKKNRIHDISNAFNSHQEILKQKLVATLAMHWAEQENIHSTKLSVACANDTTTPSFNIEKDEYLSQLRYNKWRLRELCKLVSLFGALVKTSENTPGDFTPSELHVLSLFRILLDDQAVLTPVVLKGIMFQLSPTDMQCPRVQALLDVIHKRLACWRQHDGPHAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XQ14</accession>
    <name>A0A6G0XQ14_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_002645</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000028">
        <property type="protein sequence ID" value="KAF0742371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XQ14"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018986"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03352">
        <property type="entry name" value="LbH_LpxD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007691">
        <property type="entry name" value="LpxD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002060">
        <property type="entry name" value="PRK00892.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43378">
        <property type="entry name" value="UDP-3-O-ACYLGLUCOSAMINE N-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43378:SF2">
        <property type="entry name" value="UDP-3-O-ACYLGLUCOSAMINE N-ACYLTRANSFERASE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0742371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="239" mass="25299" checksum="877DA9AD81BB0BCB" modified="2020-08-12" version="1">MMLWRRRFSTSIANPALCFIHPSAKVDPSATLSPYCVVQANAIIHENCKIGAGTVVGENVVLGSDSDIGSQVTLEHCVVGKRTVVHTGTRIGQDGFGFVLDASGNHAKKPQTLLVEIQDDVEIGSVSLFVGVRTDSCQGTKMDNLIQIGHNVHLGRNCIIAAQTGIAGSTTVGANVHIGGQVGIAQHLTIGDNVRIAAKSGVMHHLAANSTFGGTPAVPIMEYRRLMAFLRDAGRKQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XQ87</accession>
    <name>A0A6G0XQ87_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_002397</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-beta-HSD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000025">
        <property type="protein sequence ID" value="KAF0742696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XQ87"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017437"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF51">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="3">
        <location>
            <begin position="31"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0742696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="412" mass="45049" checksum="97D655AA50BA5267" modified="2020-08-12" version="1">MVVVGPSPYLSPLQRETAENGSFPPVPKVCVVTGGTGFVGQRVVEMLVERGAEKVVSFDIVPKPAQGYWDHPAIEYVVGDIANKQAVFDACKGADCVFHLAAAVGPFHPRDLYLRINYEGTLNVIEACKFHKVPKLVMSSSPSTRFDGSDIDGLTEDQLPHLPLPAYMQEYAETKAMAEMAVTAANSDTLLTVSIAPHQVYGPRDNLFIPNMLDAAASGALRVFSAPSSGYGLNKVCFTHVDNYAHALIIGERALYPGSPALAKFYITSDGDTHPFPEGYAYFWKVADELVVAMGLPALWDKMALPTWLLWPAAYVSEWVGWAIGKKFKLNKFTVRALTMHRWFNIDAAAKDLNYSPIIPFTTGWLDTHAWFRTNWMPKVLASGKSTGYGAIAAQSQAKIDVQAATLEAKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XQG1</accession>
    <name>A0A6G0XQG1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_002389</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000025">
        <property type="protein sequence ID" value="KAF0742688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XQG1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003113"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0742688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="93" mass="10048" checksum="68589465CF6877A4" modified="2020-08-12" version="1">MADKVGVSMTIRFRGEEVHAFSVNPEEPEDIYDTTQSATVPHAYSGREDGGDLPQPKLTGPHAILVTAIKNAKANSEGFLADKCEGPVKFDDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XQL3</accession>
    <name>A0A6G0XQL3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_002496</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="VJMJ01000026">
        <property type="protein sequence ID" value="KAF0742596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XQL3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014229"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051420">
        <property type="entry name" value="Ser_Thr_Kinases_DiverseReg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48005">
        <property type="entry name" value="LEUCINE RICH REPEAT KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48005:SF13">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DDB_G0278509-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026328013" description="non-specific serine/threonine protein kinase" evidence="10">
        <location>
            <begin position="19"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="517"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="720"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="602"/>
            <end position="867"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0742596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="878" mass="94885" checksum="7AC9BDDA392FA71E" modified="2020-08-12" version="1">MRATAVAVLSIGLLAAAAEDSCSLEVSLLTSRCGHVVIVDDKSRICPYAPETCSVLSQGCFDSKGKAITDFDTICSYDAKKCKNATTSTLNSVFANVDSDNAGSTDIGPDVKSFMEIGAVCYDYSGKDTGSVIVRQHSCVVDKTCQTQGFTGSLQDSPYALNDIPPFGPNSTTPSFANFNLVQLGTDLSLTLSNQSNSAATSLDLSFNKISSISDTVFPSSLTTLIVRSNAITSLGNLKKNAPALMFLYSSSNSLASFDGVNFPDKSSVFTFNDNKLQGKLNASIFPSLLQSLNVAQNQITHIEGTFPTSLKNLYMGSNKLDAFDWASSRSPLATVDLQSNSIAQMKGDISSSVTSLDLTSNQLTSLPTFSANSKLASLNISQNAISWSSASSFPASLAVLNVSNTQLQNAVLNLSQFPSSLIALDASNCGIQTVTGDLPPSLQSLRLQQNSIGAWNISPRTVQALAQLPSLVVPTTSSCVDATTPTPVQGFQLCVSSSTLDGAPVPAPQSSSSNRAAVYTIVAGAVIVVLLIGGYIFYQRRNINYRDSIAEVPPPVEQVEDVAQTFAKLGTSKSNDASVELKSEFNRHRVPMREIQILKSLENLPTAVDGATAARSMLYKAQFNERLVVLKTLTTNEPGEAMDAFVSAIRLRAMLDHPNIVAFVGVVWSSNAQTNGYGLLLEYLSHGDLARVLAYDMSREPPERLLQWRPTLRMHYPKVSILLNIAAAIVYLHSFSPPVVHRNIQAKSILLTEKWTAKLNGFKTAPRWTPPDLITAPEVLRGEEWTEMADIYSFGILICELDLGRHPYVNPKNPENDEQIATLVKADLLQPTFSVECPVQVQDVAKRCLAFDRKSRPAAVEMEFWIRKLVRVDSNAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XTA8</accession>
    <name>A0A6G0XTA8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription initiation factor TFIID subunit 12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_001429</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XTA8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002669"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07981">
        <property type="entry name" value="HFD_TAF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037794">
        <property type="entry name" value="TAF12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003228">
        <property type="entry name" value="TFIID_TAF12_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12264">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12264:SF21">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03847">
        <property type="entry name" value="TFIID_20kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 12" evidence="7">
        <location>
            <begin position="21"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0743778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="128" mass="14095" checksum="CB323B645417FCF8" modified="2020-08-12" version="1">MSRRNNAQANAMSNGNQNDYLQKILAEVDPKFVLQPGVEELLMDMATDFVNDVTSASGRLAKHRRAAQVESKDVQLVLDKNYGISVAAKKKLHAPSSKSKPTKSSVHMHRVALKRKALTAAARAQKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XTD9</accession>
    <name>A0A6G0XTD9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Guanylate cyclase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_001539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XTD9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011330"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050697">
        <property type="entry name" value="Adenylyl/Guanylyl_Cyclase_3/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43081:SF1">
        <property type="entry name" value="ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43081">
        <property type="entry name" value="ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0743897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="602" mass="67538" checksum="48A2EAFC1831FAD5" modified="2020-08-12" version="1">MRAMPLLDEARRLRRMGFHNNYGFPIWSLIYAIVFSFSFLAAVFATISLRRSTKSVSSCVVYSMLWFFIWTSIYSGSRIAMISICINEYMKGNSSWLILDAEHDIGGFRLLGYEKDPNNNDLQLPPVHARVALFAGDAALLSCCLWMLVLVTELLRLVKRTMDRGSAAEKRLWYIYLFSNVMIILAYFTILVIFSYHQGTSGTTKEKGAELSFFSDRFRVILISAATVQSLVIFVIGFAVFYLNRTGLNLESVECRVVKSPLYKRLKRILIVYVVCTVPFLTCSWVVVARGYEYLKIIPDILTEMTTILYATSGLALAVILAASQQCVLSWCRVSEAVLHEIEANEAPLDFPVFVNTDIESSSALWGHLGSVMHDAQDIHDTLLRELLVPHHGYEITTAGDSFQLAFHNIADAVAYCLDVQEQLLLQPWPAAFVDSHMPGSATILAPRLNVLKRQKALFHGLRVRMGIHASTPAEGELFHEVHPVTGRIMYAGLSELIGREVSDLGQGGQIIVTAPIVRWLRANMSKNTAWAKAHPIVMQELGVYRVADLKIDLGIAQVVPLSLAERIDMLPPLSRIQRTISYAPRLSNNYDLLISPKEHCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XTI5</accession>
    <name>A0A6G0XTI5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_001372</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the proteasome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XTI5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020903"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03762">
        <property type="entry name" value="proteasome_beta_type_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000010">
        <property type="entry name" value="Proteasome subunit beta type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF0">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE SUBUNIT HSLV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6 10" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0743713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="230" mass="24776" checksum="2974D028C7E41E77" modified="2020-08-12" version="1">MNLAPRGYGQETERDDSSGYNLKAGEVSSGTTIIAVKYKDGVILGADSRTSTGTYVANRVSDKLTSIHDRIYCCRSGSAADTQALSEYVRYFMASHAAEIEGDALPKVHTAANLFRKLCYENKDRLMAGIIVAGYDDIKGGQVYSIPIGGAMVEQEFAIGGSGSTYIYGFVDSHWRSGMTRDEAEAFVQKALSHAMARDGSSGGVIRTVAINKEGVHRGFVAGNQLPFMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XTK4</accession>
    <name>A0A6G0XTK4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_001388</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XTK4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005929"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF22">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="69"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="69"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0743733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="137" mass="15374" checksum="0DC3DA4778E0AAD8" modified="2020-08-12" version="1">MSTRSGRNVNKVARFDPTDKNHEIVPDEEEDEEEDSDEPKAAKKTKKVAAKKGGKRKVSKENADGTPKEKRPLSAYFLFLAEERPVLVKEQPDLSAKEVVSELASRWKSLPDSKKAKFNATAAKNKAEYDAKKKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XTR3</accession>
    <name>A0A6G0XTR3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_001443</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XTR3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002682"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033192">
        <property type="term" value="F:calmodulin-dependent protein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097720">
        <property type="term" value="P:calcineurin-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043360">
        <property type="entry name" value="PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45673">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="695"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="453"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="528"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="586"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="541"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="553"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0743793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="746" mass="84127" checksum="B614542E6E7FFC16" modified="2020-08-12" version="1">MKLAAFLSSTPSKPVAFKKAPPPVSALQKDWVEKCNLETTAIDEKAINYFRTLAITTCVTEGRVKKPDIDPFFVCHAFRQGLSLPVASALDILKQATDIMTFEPNTLSLTAPLIIVGDLHGQFFDLLHLLHVHGDPGPTNQYLFLGDYVDRGPSSSEIMLLLLAYKIKFPLYVHLLRGNHECRSVSTHYGFREECWRKYGLLVYSRMISCFESMPLAATIETDYGVLLALHGGLSPEIQTIDEINDLDRFVEPKPSGALCDLLWSDPSKDKEQNEEWAPNPVRGCSYLFSEQLVRSFLKRNNLLAIIRAHEMEEAGHYEHYTSNISLESFPPVVTVFSAPEYCGVYQNMGATLFLTFEWHGHLDFVQHKRSIAENCVYVENEGDAIENFLASEIPFLPMSFPQLVTLCSKVGPGLHVVQAVATPSQKAWKKISLLTQTTNMFSQWMKRKQSIDVEKPLPVTKPKPKPSEPRSNTGSSRGKRSSNFTPPSEINPAAVKAAQQKEIACIKVSSRIAELQNQIFQSVTKSGLPMCQPTRSLSNVDEDEESEEEEEVHSKAKERSRSFHEYDLKDSRVAQIRRAWQTKVNEETEKKLGPLPDPRSLQRRPSVEKLQGQIDIVNALQAWEGKKETKPKAKTEEVSTKATIKKQLTAESFTTEEWRALKLYFAIVTRDDNAQLTKKKLGQLLEDQDKDAYATQDELSTIIGAMDSDEDGVIGEADFLYFAYRAKEHSLHAGQRHTLTRRLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XVZ4</accession>
    <name>A0A6G0XVZ4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA alkylation repair enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_000713</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000007">
        <property type="protein sequence ID" value="KAF0744853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XVZ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006369"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06561">
        <property type="entry name" value="AlkD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014825">
        <property type="entry name" value="DNA_alkylation"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34070">
        <property type="entry name" value="ARMADILLO-TYPE FOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34070:SF1">
        <property type="entry name" value="DNA ALKYLATION REPAIR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08713">
        <property type="entry name" value="DNA_alkylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0744853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="34058" checksum="6F038A6C94CB704D" modified="2020-08-12" version="1">MRGLRSKKVVEKGKAAASSLRQTLESLADPSYAKKTERFFHRSYCESDIFIGIRMPQCRAAVKAHIGTTTLQQVKELLHDARHEMRMAGFISLADVFHSPAIAPSSWWDTIDQSAEDSDDQKRLHISQLYLAETRYCNNWDLVDCSTNKILGETLVRFHAEQLQDYATITKIEALPDWYQTLLCSHDLWETRISIVLLLKLISTHRSVVYKICLYHLERFDADPSLRCTIKGVVFPSLDLIHKALGWILRETGKQNQGDLVAFLEAHATKAHKTTVRYATEHLDKSKAKRFVNQAKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XW86</accession>
    <name>A0A6G0XW86_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NADPH--hemoprotein reductase</fullName>
            <ecNumber evidence="8">1.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_000553</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.4" evidence="8"/>
    <dbReference type="EMBL" id="VJMJ01000003">
        <property type="protein sequence ID" value="KAF0744968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XW86"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003443"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000001">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000001">
        <property type="entry name" value="NADPH--cytochrome P450 reductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF17">
        <property type="entry name" value="NADPH--CYTOCHROME P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="9">
        <location>
            <begin position="40"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="10">
        <location>
            <begin position="244"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0744968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="644" mass="72137" checksum="653BAD25E76782FB" modified="2020-08-12" version="1">MGENLRIAMNCLCHFGKTRPMGNNKSSSTASSASMRKKVVTVLYGSQTGTAETFAKMLVTQGRQHQVEVQAINLKRFNPATLPNHSHVIFVVATYGEGGPTDSSSKFHKFMTSAKLSDHYYRQIQYTVFGLGNKKYRSTYNAMGRAVDAFMEKHGAHRVYRRGEGDDRACIEDDFDQWRNGGLWDAFATVDMATRLTLSSSMTQSMSKTRPPLMYYEIVPALKSVIPTQPLHPSRIDPNSDFFFNHKTAVVVGARELRRSTASGSTLFLELDIRDSGVSYVTADNLAILPENDPALVTRVAKALRYDATAMVDLKPVEGAPNRSPFPTPCSIETILSRYLDLNSAPRKSALSFLAHYATAAPDHEKLLYLASTDGKAEYKRWIQDACRTFADVIEAFPSLEIPLAAFLHIVPTLQSRYYTISSSSQVHPTRIQLTFAVIQASIENGRRFHGVASNYLARIAHEWLEETPEEEFAPVVRMYLRNSLFKLPVRPETPVIMVGPGTGIAPMRAFLQERQAQKQAGEPVGPTWFFFGCRHKTQDYLYEDELASYKANGTLTELHVAFSRDTAEKVYVQHHICQRGAALWELLAAGAHVYVCGGTLMGNDVQKAFVELVQFHGGKSPLDASHFVRELQRSYRYVQELWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XWG7</accession>
    <name>A0A6G0XWG7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_000715</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000007">
        <property type="protein sequence ID" value="KAF0744855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004385"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000289">
        <property type="entry name" value="ABC transporter G family member 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000528">
        <property type="entry name" value="ABC transporter G family member 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013581">
        <property type="entry name" value="PDR_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08370">
        <property type="entry name" value="PDR_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="438"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="468"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="512"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="545"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="581"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="606"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="668"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1083"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1116"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1157"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1195"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1225"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1327"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="70"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="747"/>
            <end position="988"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0744855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1352" mass="150580" checksum="1FDC49C21558C1AB" modified="2020-08-12" version="1">MASQEIPKSPQITAASSEEFHEMLSSTIEKATGQTMPQVEIRFKDLCVAADIVTATNDGSSELPTLANHVKKSILSFVNSKRVIHKDILHPMTGVFKPTTMTLLLGQPGSGKSTLMKLLSGQFHKQKKISVGGDVSYNGIKLAETIKTLPQMVSYTGQRDNHFPLLTVKETMEFAHQFSSGGVVPQRTLDSLSNGTPEDNARAKEYLREVYQDFPDMVVRQLGLGICEDTIVGNAMLRGVSGGERKRVTIGEMEFGMKQVSLMDEISTGLDSAATFDIVKSQRSMAKCLKKTIVIALLQPSPEVFELFDDVMIMNEGYVIYHGPREEALPYFESLGFKCPPNRDLADFLLDLGTPQQLQYVVPGVTNVPRYPIDYSTAFKASPTFESMNAYVEGPVHPLLLHDATHRMVDIPEFRNSFMGETALLVQRQMKILLRNTAYIKTRAIMVIIMGLLYASTFYQMNPNVAQVVYGVLFQSILFLSLGNAAMLPTFLEAREVFYKHRSANFYRTLSFVLAQTLTQIPFGAVEAVAFGSIVYWISGFVANFGAFVVFELILILTNISMSAWFFFITMVTPNLHVAKPLGMVSMMLWVLFSGFLIVQSDIPDYFIWIYWINPIAWSILALSINQFTASEFNVCSYRGVEYCAQSGGKTMGHVQLEQFGMPVDTTWIWTCLIYLIGLYMLFVGISFAALEYLRYENSHGFAHSEEHSKDEEAEKAAYQKMPATPVGSQVSESVIVPVQSFVPVSLAFKDLHYFVPNPTKGEPELELLKGISGYALPGTVTALMGSSGAGKTTLMDVIAGRKTGGKIVGDILLNGYKATDLAIRRCTGYCEQMDIHCESATFREALIFSSMLRQSSDIPTATKLAHAEECIRVLEMQNIADFIIRGSSVEQMKRLTIGVELAAAPSVLFLDEPTSGLDARSAKIIMTGIRKIASTGRTVVCTIHQPSKEVFEMFDSLLLLKRGGETVYYGDLGTNSSLMMDYFMRIPGTPEMTQGYNPATWMLEVIGAGVESKHLNTTDYVKVFQESQEFKQLEAGLAVHMQPREDVPEMSYTSKRAASNAVQCQYVIQRFMRMYWRTPSYNLTRILLSIFLGVVFGLTYVSIDYTTYSGVNGAFGMVFITTLFIGVISFNSVLPLAAGERPSYYHERASQTYSPFWYLVGSTVAEIPFVFASTFVYTVIFYPFVGFRGNFSDMAYYSFQLSLVVLMNVYFGQFVVFATPRLDVAVSIGALVNSTFMLFMGFNPPQSQIPSGYRWLSTIVPPKYSLSILLSEIFAKCENGSGLGCAQMANVPPVVLAELHKSSVTVQEFAEFMFHTKNGDNFKNTMIILAVILLYRALALLAFRFMNYQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XX99</accession>
    <name>A0A6G0XX99_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_000687</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000003">
        <property type="protein sequence ID" value="KAF0745117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XX99"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008836"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0745117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="110" mass="12612" checksum="39D83F5FCAAE0057" modified="2020-08-12" version="1">MFNTSRAKAAPTLETAPTFKELLEESRRQYDLAHGDFSLAIPLHLKALVTLDKACNRLRQWKDAHPDFDASDPRLVALLQDYSDADDAARMADQLIREACQRRCRAERLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XYT1</accession>
    <name>A0A6G0XYT1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BCCIP family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_000164</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BCP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000001">
        <property type="protein sequence ID" value="KAF0745715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XYT1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015447"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025602">
        <property type="entry name" value="BCP1_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261">
        <property type="entry name" value="BRCA2 AND CDKN1A INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261:SF0">
        <property type="entry name" value="BRCA2 AND CDKN1A-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13862">
        <property type="entry name" value="BCCIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0745715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="30769" checksum="70049C6551A4A78A" modified="2020-08-12" version="1">MSKRNVGEIHDDSMGESSGDEEEDIVLKSNGDQKESVEVDFVFTDPCEENYHSVKQLVNNFLPSTSLDTSNLANLVVNQVSTGSMVCCEGETDVFGFITALSLARYQAEPSIRQIVALVQEKCPSDLKAKLQNILSTKSVGLVLNRRMINLPYQLVPHLHHALQQDIDWAIQNEPDQAIKDSFRFDYFLMLAGVQIDNSAAKKPAGKKVKGEYAEPSIKSFDNFEEEFLEAEAELSFTFSTQNVLKEGAGISTEITVLLVERQKHNGTIASMTAMLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W413</accession>
    <name>A0A6G0W413_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_018855</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="VJMJ01000361">
        <property type="protein sequence ID" value="KAF0721868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W413"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015426"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13999">
        <property type="entry name" value="STKc_MAP3K-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000060">
        <property type="entry name" value="Serine/threonine-protein kinase isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF288">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="320"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="80"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="190"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0721868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="575" mass="63826" checksum="DBD8B60BAFF1C016" modified="2020-08-12" version="1">MLDQVLTGSLCFLALAIYMYMKFIRRDRTAGFEQVKPMKEAQSPPSRDMELQMQPANAQNNHPQRKQPKGHYVYQHPMRRRTHSSMTNAEPIPSPMDMSIAIEQPPPPPPMPPPPPPIPEEPSFFSPKMEPRIPLLSRVVAHASPDLRVVSPKKNLSLSPDIDLFADIPSDRNSLSRLESQRVLSDVVLDMPTTSEQPKTSELTVVVTSPPLSPPTPPLNPTPRAKLLMDDRNQPAQMQLEVARKAHIPLFLHLPLHPRRDDGGVTPPAAAEAGVGSPPPAAAFAEPAAKPPVAPVVTAHQVKRPVRTNTFNFRIDFKELTMGELIGQGAFGTVHKATWRGTLVAVKILQVQHLSPDVLEEFETEVHIMSVLRHPNICLLMGACMDPPTRCLVVEYLPKGSLWCVLRQPGVDISLKKQLGFALDTALGMHYLHTFDPPILHRDLKSPNLLVDGSYRLKISDFGLARVKAHHQTMTGNCGTTQWMAPEVLAAEKYTEKADVFSFGVVCWETVTHACPYDGLSQIQAALGVLNHNLRPTIPPDCPPFLKKLMTVCWGPVPEKRPTFAHIIDMLQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W446</accession>
    <name>A0A6G0W446_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_018946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000368">
        <property type="protein sequence ID" value="KAF0721731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W446"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007459"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0721731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="195" mass="21570" checksum="72BE42B1C297A087" modified="2020-08-12" version="1">MMMNKEKLEEAVAKSDGRATVRVKMADGSVAEQPRVLITLPKRVGQFVSDETYFVIDLDERWDLILGMGWLEKHQPTINWKLKTISKSLDANKALGLVSNEPTPNETKSPRRVTLAVEGLATHGHDIALMKAADGQRIASADEDCDGTGDTMTSEDHVDIWGVECDLEKALRDGCAGSRDDPTKKKDATMSWEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W5A6</accession>
    <name>A0A6G0W5A6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_019233</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000531">
        <property type="protein sequence ID" value="KAF0721068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W5A6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019276"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0721068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="173" mass="19581" checksum="16A681AE78839F7A" modified="2020-08-12" version="1">MERGVTPEELVLSQCDLEELPQVAEEIVKLPEMSFAEFEKALRQQDVVSIALIQAVEEVDLRSSSTLDTDVDGSKPASTYAATWASLKTNAFYDLIREFEDIFPEEVPQALPKDKGVRHEIDLIPGTKWCVTRQWPLPKEQVDHIDAFFEKRRQAGHVRPSTSPHSSPTFCVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W8C9</accession>
    <name>A0A6G0W8C9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_017736</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000309">
        <property type="protein sequence ID" value="KAF0723396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W8C9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005004"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05941">
        <property type="entry name" value="MCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF8">
        <property type="entry name" value="ACYL-COA SYNTHETASE FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="20"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="3">
        <location>
            <begin position="399"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0723396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="488" mass="53810" checksum="2A9285B6D1323EED" modified="2020-08-12" version="1">MRLLQRLYEARGVLCGPKGVTSSTQQLMRQALALSRQLPPASSSSEAIAFVAHRDADYLRNQWAIWLSNRMAVPLSTSSALSERHHIIKDSGASHVISHPSMDTSNLSVPSFTFRDVTHEASEEDLLTRLKQPALTENAMLLYTSGTTGVPKGVLATQSSLFAQVNDVATTWELSPADHVLHFLPLHHAHGIVNNMLSPLLGGATVDCLEKASPAEIWSKLSDPANPVTVLMAVPSIYMMLLESFEKMDAKAQANAKAGLAHLRVAISGSMACPVSILQRWQALTGGKMLLERYGMTECGMALGNPLHGERHLGFVGQPFPSIEARTAPETSELQLRGATLFKEYWKRPIDTKEAWTDDGWFKTGDIAAYDEQRKSYKILGRASVDIIKSAGYKISALEIEQVLLDHPQIRECAVYGAEDETWGQIVTAVLRVDPDVKNLEPSLEVFLQNKLAKYKKPRQIHIVEEIPKNAMGKINKKQLAKLFATTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W901</accession>
    <name>A0A6G0W901_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Core-binding (CB) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_017448</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000297">
        <property type="protein sequence ID" value="KAF0723673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W901"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019375"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020760"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0723673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="431" mass="48526" checksum="91B9759E2F01E0C8" modified="2020-08-12" version="1">MPRTGRNREANALDPTRSVVTLRLVDDTRAQYNFYIQRMKRFLLASFPQFVVNSEIHLPLTLEVCEAYLNYASVKRDKDGNDINPRMYNTYSTINACKSAIKYLYKEADKIPSSDLNILLKDFFSGYKRKIELLKEGGQMPIGEGKSPMSPAGFLFLSEKALTAKSDFALSTTAHVSLVMCWNLIARAASVASIRFDNMSWEGDALLVQYGRTKNDQEGTSCSPKHVYANPSCPWICHILSLSLLVFTRGMPTSGSTTLLLASNSQERFSEWLAKISAGYGDDIASMGPTATPCPTQTSTVTPHNQGLSSAKVRCPTSKTYDLWTMWWSGRSLDKAIPLRKLRRRDYKQTSEKVNFSKASTVMRELLSCTNLNEPDIVKMSQLARDLLFQSCFNQLCGKVFQSCNDSQVVQRRVDEMSYHTIYDLLKKASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WCA4</accession>
    <name>A0A6G0WCA4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_017022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000274">
        <property type="protein sequence ID" value="KAF0724260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WCA4"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0724260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="102" mass="11148" checksum="7138A9627A5471EF" modified="2020-08-12" version="1">MQAEGSGCGPASEAAPGGKAEHAVEQTQFSYPIPNPGAITMETTQLILAWYFAQEHAVKTRSRFVGWTAMVLHVYLRLALKKTHVCPKSRPERSGRLESHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WDE7</accession>
    <name>A0A6G0WDE7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_016254</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000247">
        <property type="protein sequence ID" value="KAF0725237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WDE7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001629"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35833:SF1">
        <property type="entry name" value="GALACTOSE-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35833">
        <property type="entry name" value="GALACTOSE-BINDING DOMAIN-LIKE, ARMADILLO-TYPE FOLD PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0725237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="214" mass="24071" checksum="651ED8C376DD3D8B" modified="2020-08-12" version="1">MEAAALTFRVLRATGSSFEHPVANLTTYSRKSYWASFAKPKEVVVLAIDTKALLGEVRIFNKNAHAVDIDVAVDDKLEEYVKVKTIVRLPLNREFRIKLGYLPTCFVRLTFHRQSQNYIAVYGIQPIGIPWGVLEQGGGPSLFHVVSSTTEKLLFGPSLPASLPRRDCLSDTISGSPAWMQRHKSLLETHITRLENSLAEFTQDPPHRASSWMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WDV5</accession>
    <name>A0A6G0WDV5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_016041</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000241">
        <property type="protein sequence ID" value="KAF0725478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WDV5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002561"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF98">
        <property type="entry name" value="FI18310P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Peptidase S1" evidence="5">
        <location>
            <begin position="1"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0725478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="239" mass="26217" checksum="C3541080639591CF" modified="2020-08-12" version="1">MVNGTNIDKAPTPAYIATMGAKDQKTPDCTGILIAPRYILTNALCTLMRPQWATINSKYSRGGDGEQIAILSHVVHPKFDRWTLTYDIAVYLLERASINKPATLTFDTYDTATPVVFRGFGLLDYNAGFVDVLQEAKGIVAVNSDCNRVFRLDVYLSYRFLDDMMCVVGLTTCSGDGGPLTVVKKDGQEAVVALASWSSYRCKNQFGGFTRLSASQDFIKFFLPGGDVCTGPVERPSLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WE10</accession>
    <name>A0A6G0WE10_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4203 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_016249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000247">
        <property type="protein sequence ID" value="KAF0725232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WE10"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014689"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0725232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="26373" checksum="832614CC379CDC46" modified="2020-08-12" version="1">MSLLASATMMMAKSSSGRRLGDIGDDLVSIFILIFSFIGVPLSIFVAVRGLAFPRVSAFTSVVMTGIGIAFLGPGAEFVIGMSSILILTIVICLVKDSPVFLLSANAALCIAYTIFTMTLPQVVNTPSGYVPASSVNTTLPIEFQEPGTFATVVLVVCFLGFAIAAGVAALKIGRPLIAASSSVVGIWFSVYLVGAYFSRPIVDSSYDYFKIFALKPWITWPTAVVLSALATLLQLRTIREVPEVQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WEF6</accession>
    <name>A0A6G0WEF6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_016657</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="VJMJ01000265">
        <property type="protein sequence ID" value="KAF0724726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019268"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019899"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054465">
        <property type="entry name" value="Integrase_p58-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22938">
        <property type="entry name" value="Integrase_p58_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="9">
        <location>
            <begin position="468"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="10">
        <location>
            <begin position="1081"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="345"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="879"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="354"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="879"/>
            <end position="914"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0724726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1498" mass="169232" checksum="CE8045381317B1C0" modified="2020-08-12" version="1">MDDLTDVAEHADGEDSASTSFEDAKLPPDCVTYPSDIPTLCSGVRQSENYECSDEFWNELPLDYPHSTPTASTQARLKSQQLRSLHRKSAKIDPTYCSDLLEGNPPSVRLLCRLTRLCHTRSRSDSDPFIQAYVNNMKAIDTGATSSFVSATFWHKLGCPTLSHPRSSFVSADNSQLEMLGRIKLTINLAGRKVLFPFWVMSTALTDCIVGIDLLRQMGAIINLNDNTLSIDGCDELISLSPLSPAQQETHPTGPVTVATATQIPPRSFQWIACSAGSDLPTLTTILVEPNKSALLNVAAALYRTYPSRTVLLEVANPSDSPIHLPAHAIVGTWMALPKDHLESTLDSHDSRARTANGQSSQTTDEPRRVLTQIGGRVVCPVQSETTPTKELPIDWTESSLSIDQRELLRKTLMKFSDIFVDSSKAPGQTHLIEFSIDTGNNPPIRSVPYRTSKAEGDTMEAELNQYLDLGLIRPSKSPWSSPVLMIRKPDGSIRFCIDYRKLNSVTVKDSYPMPRIDDLLDVLGRAKLFSTMDIASGYWNVPMAKDSIEKTAFACKYGLYEWLVMPFGLCNAVPCFERLMEHILIGYKWRTCLVYLDDCIVYSEDFGSHLIRLSQVLTKFREAGFKVKMSKCKWGRSSVPFLGHIVTPAGVLPNPEKIKSVLRVKALKDASEVRAFFGLAGYFRRFVRDFSKIAAPLTNLLTAEQFTWSTACDEALESLKRSLVSPPILAHPDFDLPFSIWVDASHIAVGAVLMQKQQNKNRVIAYGSQSLTKAQQKGISKEMGISEIECWGIVWATRKFRPYIDRRHFDIYTDHEALTWLFNTGSRSGNHKLARWAMEIQGLDYTVIHRSGELNGAADGLFRLAVCPIQTRHMSRLNSAPVNLQPSLTLEGSSPDPTESNTPATGSSQSRNPLQPPNPRVSTTPMELFDRRGRPSPRLYNEQANDPWVLALRAYLEDGAIPLDPYLQNLVVRNSQQYLMQQGIVCRYVTIKIPLRNPELIIVPAIPHSLVEEVLYASHASPVSGHLGLMKTRERILRTAYWLNWQLDCKDYVSKCPDCNRAKGGRPWRQGSMQRMPIYSLRGPFGLLVVDALGPLPTTNRGNKYILVFADYFTRWVEAFPVADLKTSTFTRVLIDEVLCRFGIPDKLLSDRGSNFVSELATTMYTTLGIHKLASAPYHPQGQGLVERFNHTIVQMMKIYVNDHHTDWDTYLPRLLFAYRTAHHETLGDSPYFCLFGRDPTLPLDLAFLNSDPTRKSDDLPQYKRRLASSWKEMRRLVENQMISGQNKSAAAKSDQKPISFDDQSAVWVYKYFSKSNNPDDKRTPKLATHWHCPYRIDRKMGPNTYKINIPTHPDKIVTVNVDRLKPFKGYYSRPFNEEVPEDESPLDDFTIDCLPRSSFIDRVDYSDGDVAYSSVDSPIHKICDKRRLPNSREPEYLVEHVDGYKYWTQASKLSEYRSYIDNFENSLRMEKGLPPLRRSPRFVDLDKETQPMDIYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WFB7</accession>
    <name>A0A6G0WFB7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_015647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000229">
        <property type="protein sequence ID" value="KAF0725982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WFB7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013888"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0725982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="39877" checksum="E498BCDDC613DB4C" modified="2020-08-12" version="1">MMRSYKHEQDREASIDSFVSSHVVKCVGEWTGKGNLHTYPNAFVVETLQSKLFHCSADTPEAKQAWLNSISVYDRLSLGSSVPPTDVPTPTNGYESSEAPEPVTESPPSVVIPARPIERSRPKSERDALFQPKSRRSNFDDIEIEDETTGPRDPAVGLDKSLWLKASATTLSIDEDDDIPFVHVEAPPSSLRMKYTTTPAAEPPLATPTVVETPEEYIELDPDMVARFSHMRMMEARGQASAVEVSSLSRPSKRVDRSKKSKKKTNSSPVDDHNVIEKSEKKKKKSTAVTIDSEEPIVKLEKKKKKKDKTTDTSEKKKKKSTSEPPPMPLEEPKYYPEPAPIAPPPPRSIQLPAIDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WFI4</accession>
    <name>A0A6G0WFI4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_015780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000232">
        <property type="protein sequence ID" value="KAF0725815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WFI4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006153"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0725815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="324" mass="35961" checksum="4043670229817DDD" modified="2020-08-12" version="1">MIAFAATTDVGNCRANNEDLYVILPDLPTPQTDFAKRRSAVVVLDGHGGIRAASFVRQFFETEFISSEHYGVNTAKALEACVQTLDKRFLELARKQHWLTDGTTLVAVVIEDTPNERKLTTANVGDSRAIFISPHHTREITIDQNAARSDEAFRVYDSGGFVSFTNRYRPPPTALVRPLRCLRHIVDGWNKWVQHRPLRVYPGGLAVTRSIGDLDCKQAGVVICDAECVEYVLTSQAKCQQDTSASSGLIIASDGVWGVESTHTVWRCVSKQLKTRCSLQERADIMSTSVVSLAKLHPRSTDNITAVAVVFDQIYHLRNVTSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WGC8</accession>
    <name>A0A6G0WGC8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HutD family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_015716</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000230">
        <property type="protein sequence ID" value="KAF0725946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WGC8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017493"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20293">
        <property type="entry name" value="cupin_HutD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010282">
        <property type="entry name" value="Uncharacterised_HutD/Ves"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37943">
        <property type="entry name" value="PROTEIN VES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37943:SF1">
        <property type="entry name" value="PROTEIN VES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05962">
        <property type="entry name" value="HutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0725946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="20890" checksum="EE2ED36D45BE6D4E" modified="2020-08-12" version="1">MWTEVSVERVPPSRWLNGGGQTRELVAWPIGLPEWTLRVSIADIAQDGPFSAFHGIRRWFAILEGGGVRLADSVNLTVGDPLYEFDGALAPACSLLDGQPVRDFNVMSRENPEHTVKVIDAKSEPAWTASLKTKWIGLFTVDQGAIVVNSTGTKELGRMSLIWSDSLEPSTTLTAQFFGSGAAYWIILEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WGL3</accession>
    <name>A0A6G0WGL3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_015399</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000219">
        <property type="protein sequence ID" value="KAF0726284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WGL3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021543"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032483">
        <property type="term" value="P:regulation of Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08204">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005112">
        <property type="entry name" value="dDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051696">
        <property type="entry name" value="DENN_Domain_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021881">
        <property type="entry name" value="NACK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005113">
        <property type="entry name" value="uDENN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296:SF21">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03455">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11995">
        <property type="entry name" value="DUF3490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03456">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00801">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00800">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="3">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="UDENN" evidence="4">
        <location>
            <begin position="174"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1214"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0726284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1248" mass="141527" checksum="5D5FA016F54DF391" modified="2020-08-12" version="1">MQGQLVELLRQSGEICADCAAPLGGSSAAWASVSFGVFVCLECAGVHRNLGVQVSRVKSVHMDTWNADEIELMKRNRVNSASLEAHLPLGIKASVRQSNASRVVFIKAKYVSKIFTTTGGLQFRLPNGENSQTISSPATTSASSSMPRQSSSIVEVTKRFVNYFVVVGRGAILKQTVVNSSSPNDVQFQPLILDSYPDALPDVPLPTHIAQFAFPEGLALSSTFREPSFFSFVLTNVSGAKLYACALKFDELLTPFEVLGLFMKETIPAWAHALSNGTKQTGASQTTTSTATSVYSPKCLVVVSHYPFFSCFRTFLQQMYRVSLSETPLPLERYIANFVAEIPVPPPGRVQVQLTLPERTLMVSRPPKNQLPQADFSFRPLFQMLDLHNVMTVFTCLLFEQKVALCSKHLSVLTPIAEALVALLFPLYWQGAYIPILPSSLLDVIDAPVPFLVGVHAKYLATSPSRATDVFFVDLDHNRVLPPSNELGQETIVLPKLPERESAKLKAKLIACANIFDPFAAEIAKSDVAFDKTDDYLKPLNDVGGGMTVPVQEFASSPSSSSFSSMDYVERKTSGFGMDRKSTFQTLLTFVPSQSTLTERSMSTSSSASLLQQPPPSPHALNAFDADAIRLAFLRFFVSIFKRYATYFNPKAATPGSKEVLFDRQGFLRDQSDATSRPGLTVLLSTQMFERFCEDRIVQPSQLPDVRFFDASINQKLNRSSLSLSKKADVSFLEDKTDVIRETFVSPPPSTLGLPDDGTRYKYRNGFPRLKRHLFGTIRKPRELYSSREQQRHVASAVDVHQQIYRLSTCVMEPGVSWEATRKLVVRLQAITRMHQARKRYRKQREALISIQRFVHAHFQRRACEAKYKRYRQALVTLQTRWRCRTLRREYLAQKNAIAVLQRVLRGFVYATRYCHLRHGIISLQALHRCRIQRRWFLQQKQRLVHVQSHVRGMQARQTSRRWRKTYLAELRHGLFDLWAQAAVPLVYRAKFWLSYDRADFLSIGVYLEEMARVRALVGEAKVVPSNQNNSMDIVLTRKAKKQREKLLHAPPRHEAWLPLAQARLDEERLHLYNQLKYHTTETMLHSFYRSFELSLESKKRKRKLVELLWNCLDMATTSAEVVLAISSQQMQVNDAMETKLHSRICTDLVYTVNAAMSSLQKTTQKSSTATKKREQEDQRQLVRAMVYQNHCLEIQLAQMQRQLVEYRQIMAAASTQDPQPQDDDSSVQERRRPSFLMRTDPAYSKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WGX0</accession>
    <name>A0A6G0WGX0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ADP-ribosylation factor-like protein 2-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ae201684_015357</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Microtubule organizing center</location>
            <location evidence="3">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ARL2BP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000217">
        <property type="protein sequence ID" value="KAF0726389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WGX0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013113"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051457">
        <property type="term" value="P:maintenance of protein location in nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1520.10">
        <property type="entry name" value="ADP-ribosylation factor-like 2-binding protein, domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038849">
        <property type="entry name" value="ARL2BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023379">
        <property type="entry name" value="BART_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042541">
        <property type="entry name" value="BART_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15487">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15487:SF4">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11527">
        <property type="entry name" value="ARL2_Bind_BART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BART" evidence="14">
        <location>
            <begin position="36"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF11527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF0726389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="160" mass="18457" checksum="0CE4398C1515F941" modified="2020-08-12" version="1">MSAEENQPEIASYDDEEEENFSTDIDGGSAEENKLDEAMGVIQDILIDPEFIQLQSDFCQKHCEYFDDASENKLIYMDLFKEYTLLIENYLEARLQAQIDGFTMEELCQMIQEHEDDITGDVIDILMSCADFDEFKSLMLSFKQNDHAVFEIQGDSLICN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WHC4</accession>
    <name>A0A6G0WHC4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_015185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000213">
        <property type="protein sequence ID" value="KAF0726560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WHC4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020934"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37067">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37067:SF3">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="164"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="242"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0726560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="294" mass="33983" checksum="A990C1511E6B9022" modified="2020-08-12" version="1">MMQEDQSQKELKDRLRRHHWIPKYEIEFGLQVVERHPHTGEVILAVCGLCKSFGREVRDKDDEVVSPSAGGQRKRRRGLTTTKYFRSFRVDNIRSHLSGAHPVRWQEYQVLAKNEELRRNYLAQSNVSMGLMTSLPMNMMGLPTGMDDAGDLDSETQLAMHAIVQQSSSSTAQRSSAASTPSKRSMPASMSSGKARPPPLLDPKTVELQRYQLDWERLEFERMRFQKELQMREWDEKQAERKMKHEKEMREKDRELELEKAKIEQEKFNKLVECLNRALGHNSVVASGVTNAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WHF2</accession>
    <name>A0A6G0WHF2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_015233</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000213">
        <property type="protein sequence ID" value="KAF0726612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WHF2"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0726612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="82" mass="9628" checksum="94C87488C1BBCD40" modified="2020-08-12" version="1">MVQLEIQFVQNLTPVSVLLNDVQLSQHHGYSNRVHWKYCAQLLSFEWPAVHWMNLGHCTHAAQQREPNIATNLRLFLNVMFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WHK7</accession>
    <name>A0A6G0WHK7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_015153</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000211">
        <property type="protein sequence ID" value="KAF0726653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WHK7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019378"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF28">
        <property type="entry name" value="TRANSPOSON-ENCODED PROTEIN WITH RIBONUCLEASE H-LIKE AND RETROVIRUS ZINC FINGER-LIKE DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="220"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0726653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="548" mass="61997" checksum="46F46BDAC78EFBE6" modified="2020-08-12" version="1">MSAMDATTAADSYKVNKFNGDNFHLWKFKMVMVHEDKDLWDIVSGVEKWEDQADDASQASFKKRQKKAFAIVCLSLEDAQLSMVRSCTTATQAWKRLEDHYEKKSLANKLYLRKKFFACAMAEGTDMMHHLNDLKTLSEQLEAVGAPVSEEDLVITLLCSLPESYDVLITALESRSDALTWGFVTSRLLHEETKRKEQGNDGMKSAAFLTRQEKMKRFPCKICGQMGHWANKCDRRGEKKQSVAAMAKEESDYLFMASGDEKSASSGNDWFIDSGATHHMTNSMANFKNYSPMKAIKVHLADDDVIEAVGQGEVVMKLMTPQGPQLGVLKNVWFVPKISRNLFSVSQFATDGAKISFEKNNCIMEKQGRSFNIGSRFGKGLYKLSMQPVKEGSAMANLIEVKSTQSKLWHDRLGHIGCQGLETLVKNDMVSDLALKTVEDWTFCDSCALGKHARFKFAKKSSNRSTTLFEEISSDVCGPMQTPSRGGNLYFVTFICGNSTYCWVYLMRHKSEVFAKFTEFHAMVKNQFKTCIKRLRSENGKEYQNKHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJ22</accession>
    <name>A0A6G0WJ22_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GB1/RHD3-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_014729</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000200">
        <property type="protein sequence ID" value="KAF0727200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJ22"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000114"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01851">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001470">
        <property type="entry name" value="Interferon-induced guanylate-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1000.10">
        <property type="entry name" value="Guanylate-binding protein, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030386">
        <property type="entry name" value="G_GB1_RHD3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003191">
        <property type="entry name" value="Guanylate-bd/ATL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036543">
        <property type="entry name" value="Guanylate-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015894">
        <property type="entry name" value="Guanylate-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10751">
        <property type="entry name" value="GUANYLATE BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02263">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02841">
        <property type="entry name" value="GBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48340">
        <property type="entry name" value="Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51715">
        <property type="entry name" value="G_GB1_RHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GB1/RHD3-type G" evidence="7">
        <location>
            <begin position="32"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="591"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="724"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="498"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="591"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="609"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0727200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="746" mass="83569" checksum="AD56782F626D3E7E" modified="2020-08-12" version="1">MSLSEPLPFITLTDDDCFSISPEAAEYLKTVEGEVSIVAIAGLYRTGKSYLLNQLLGRTTEHTMFGVGGTVNAMTKGIWIWGQPVDGTGGNKTIIFMDTEGLGSAQRSQTQDTRIFALALLLSSFFIYNSRGVIDANAIEDLSLVVNLTKYIQVSAGGNGSGGNLAEFFPAFLWVVRDFTLQLEEEGKAISSRDYLEKALKPQPGTSDDTQHKNQVRQLLSNFFPQRDCITMVRPLNDEALLRELPKQPFESLRPEFRTQLESLKQRVFTTLQPKKLMSKPLNGTMLVTLAENYVEAFNSGAAPVISSAWDRVVQAQSEELLDASKDAFTSAFAPNTTALKDDDLLKAYQAAEAKAIETLKASAVAADTVPLTLPQLQDWMQEKLRAAWEHNDKLAKKHLIGVLQELYAPIAAQAWQNLDKDAPVDQVLTALRSKLAGFDHLLKKFVDDYLAATEGYPLQSYMLASFLAEKIMDGVVNWGTLVTVLFRQQDGILQKNISTARQKVKALEGKAKAAQEMLQQQKETYERALQGISDRMQEEKLTLRAEMDHKDGEIKRTMMQIDRISTLHAEALDRLAEELKSAKEELKEVEAQVDAARREQDSLAQDTAKQRLENERKKNEKEKDLLEAHHKLREKVVDLERQLGEQQAEHMTAIFKMEQTCQEKVRVVEAECEDQAAELKGQTISDIRELKTKQESELRALQVDLNDRQAILSAMQERLELQRRQNMQNAAGGKKGGNKEDCVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJD1</accession>
    <name>A0A6G0WJD1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">T-complex protein 1 subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">CCT-alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_014566</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000198">
        <property type="protein sequence ID" value="KAF0727305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJD1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010193"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03335">
        <property type="entry name" value="TCP1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000009">
        <property type="entry name" value="T-complex protein 1 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000070">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012715">
        <property type="entry name" value="Chap_CCT_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02340">
        <property type="entry name" value="chap_CCT_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0727305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="543" mass="58568" checksum="8AD836B71A327E05" modified="2020-08-12" version="1">MDLVVDGKRTSGKDVREQNVMAALAIANIVKSSLGPVGLDKMLVDNIGDVTITNDGATILKLLEVEHPAGKVLVELAGLQDQEVGDGTTSVVIIAAELLKRANELVQNKIHPTSIISGYRLAMREAVKYIKEHLSVPVDSIGRASLVNAAKTSMSSKIIGPESEFFANLVVDAVTSVKTTEEGAKGKVVTKYPVSAINVLKAHGKSALESQLVDGFALNCTRASQAMPSSVKGAKIALLDFDLQRHKMQMGVQMIVHDPKEVEQIRQREIDITKERIHKILDAGANVILTTKGIDDLCMKYFVEAGCLGVRRCKKEDLRRIAKATGGQVVLTLADMDGEEAFDASTLGSADEVSEERVGDGELIYIKGCANRQSTTVVLRGANEMLLDEMDRSLHDSLMVVKRMLESNQLVAGGGAVETALSIYLENFATTLGSREQLAIAEFADALLVIPKTLAVNAAKDASELVARLRAHHNTSQTDASQTELRFTGLDLLAGKVRNNLAAGVVEPAISKIKSLRFATEAAITILRIDDMIRLNPKEDQEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WK12</accession>
    <name>A0A6G0WK12_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TFIIS N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_014415</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IWS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000193">
        <property type="protein sequence ID" value="KAF0727588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WK12"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009753"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051037">
        <property type="entry name" value="RNAPII_TF_IWS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010:SF1">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="4">
        <location>
            <begin position="239"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="115"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0727588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="442" mass="50367" checksum="CF2310C989C06405" modified="2020-08-12" version="1">MATDEQKNIEDMFGSDSESEEDTFKGSSAKPSAVNESTSGLFGSDSESEEDEKPKKLKKPTKSASKPPKPAKRKVSARAADDDEGTERRAAQPRRDDGDEYDSGEEAVRTKDDDAFIDDEDDLGGVLDEYDQDNQNFDDERPDDEGDRFTSRHEDDYFEETLKSMKTGRGRSKLKMSQQEIETLVQELLYNMDKAYNDDQVAMEEKKPALQKLKLVNSVLLLARKHQLQLPLLDFDFLGVVKKWIQPMENGLLPNIGLRTKMIEMCQTLPIDKEHLKRSGFGKVIMALWKHPHETPENKEICRQLIDRWSRSVFSKTLDFTKLSELEAEKREANGGVRPTIDRRPANQRNVESVRNRGFLNRGNTATDSSNSSSRVRMPEQIRIDFTLRPQPKVDASQIPSTKVDPESKKARLMKRMQIIARPTKRAKRAVKMSIEGRGLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WK59</accession>
    <name>A0A6G0WK59_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_014445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000193">
        <property type="protein sequence ID" value="KAF0727620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WK59"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020671"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="128"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="186"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="357"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0727620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="740" mass="83506" checksum="F459A0849E50FA47" modified="2020-08-12" version="1">MRSPSKDQRRAWRRAEEEAVEVAVQTDGATYGREEIEELKDRCALLATHLEQAQEELNLSIRTCDQRTAEAQASVLSWQLRYEALDKANQEQTATITALQDELAKRDRTKTEWETKQAKLLKQQTELKNQLRLATATLEGQLDDATKKAARLALERDQQLAQVQQTHDTQIQALQTAHAAEMATLRSALESEKSSLAADLGKAKQRHQLMLHELSTAEQAADEAARQLNEVTSAWTQKVAAKTTALDMAHRQIEEQEATILQLKLAASEIKITEQHEAEATFLHQIAALEAALAQANARLESSKEQHDLAMRLERDRVAHVVAQAKSVADELETANLCLAERKRQREQDQQAFEERERRAAASIAQLMEEVDRLRQKPPLPMSDLEVECRQVHKHNDDLVKQMQALKEQLQAQHAASKEGDVAVQLLEAQKRDLQHRLDLAVATAQELQRQLHDKTTQVAASMDEREQELEARLNQRLAVEKRLLQKQQLDMDAETQSLMEDKQLLAQVVERLVERLRLQLDVLALQADDKGSAKVDWTTQHAQWQRIHDQCANADWQLSHMKARLDELVIARRGRRSMKQSPFSDAIAAGHKTVDVADQIVYGSQNESDSYAAALAKEMHAMKASYEAKLAAMAAELKRLQTEPAKLDDFLDGRSGSAARIKQLEDQCAALEGSLAAHVLAKRSEKDEEVDLICKCRVERDGKAKAAYLEALLECRAKACSDDVQRRVAFEALQRKLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WK71</accession>
    <name>A0A6G0WK71_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PARP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_014293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000191">
        <property type="protein sequence ID" value="KAF0727665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WK71"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009143"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0727665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="21355" checksum="DF5F3AAE69AF90DE" modified="2020-08-12" version="1">MLPTAPQQMNAGWISKKQSRPWIRCNILVSAPTGRDPKCRACSVKIDDVRVGIIYKHELLEHICVQWFHLACVAPPPHILASDVEGLNEVAMKPYRAAVFDWLIKYDEEPTDVLLPPATIGLDRTTPSPREGLVAKAKKPPLAPPLPRPSRMLAKGVVPASKQSPGVLNSAAKDAIATMKACLADPRHTSTRMMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WL31</accession>
    <name>A0A6G0WL31_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_014120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000184">
        <property type="protein sequence ID" value="KAF0728014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WL31"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008923"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052050">
        <property type="entry name" value="SecEffector_AnkRepeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586:SF3">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0728014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="419" mass="47119" checksum="B84DA001E6609FF0" modified="2020-08-12" version="1">MAAGASTIFHSRELFLCISAFQRGVFHVALPLVRLKPEQSYLVNPTEIRAADRVLTKWYGTHGVASLPRVLECLPDMRLLLFLHAITYSRLDAVQTIHSHVQFIHLHDDVPVPTPTDRRWPATYFNHLADAAAIHGHLDVLLFLVQQQYKPCTSNALTWAAANGHVHVVAYLHTNDIRGHTSIAVEQAAANGHLNVVRFLLDHRREECTVWAVNYAAKAGHLAIVQLLLDRFDTCPEEAMIWAAGEGHLNIVKYLHHRGAACTYEAMDLAARNGHLDLVKFLHSNRTEGCTVWAMNVAAEKGFLPIVQFLHEHRSEGCTTSAMDLAASNGRLEVVQFLHNHRNEGCTPHAVRQAIQNGHTAVVEFLITHQEETSSQEAMAWALKFHQDEIIAMLTVRGVRSRHAQYEDRHIQDWSLPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WLF7</accession>
    <name>A0A6G0WLF7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_013947</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000181">
        <property type="protein sequence ID" value="KAF0728121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017177"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000289">
        <property type="entry name" value="ABC transporter G family member 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000528">
        <property type="entry name" value="ABC transporter G family member 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="467"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="505"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="544"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="581"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="667"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1091"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1123"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1163"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1202"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1232"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1334"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="71"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="754"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="701"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0728121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1360" mass="151358" checksum="102E168D646F2483" modified="2020-08-12" version="1">MTSPAHSADYLLADGTEMFHERLATSLENATGKAMPQVEIRFKDLSIAADVVLANKDGSNELPTLINHVKKSVMGVAKAKRVQHKDILHTVSGVFKPATMTLLLGQPSSGKSSLMRMLAGRFPIEKNMEIGGSITYNGREQKELQKVLSQLTSYTNQRDYHYPELTVQETMEFAHQSCGGVVPQRILDSLQHGTPEENAKAREVLEHLYQGFPDIVVRQLGLTICKDTIVGDAMMRGVSGGERKRVTIGEMEFGMKQVSFLDEISTGLDSAATFDIVKSQRSMAKTLKKTIVIALLQPSPEVFDLFDDVMIMNKGYVMYHGPRSEALAYFELFGFKCPPKRDVADFLLDLGTPQQAQYVVPGLLANVPRYPAEYAVLFQESAIYRAMMDHVDGPVHPLLLNDAMHHLKEIPQFQSDFKSSTMLLIVRQMKVLLRNKAFVKSRAGMVIIMGLLYSTTFYQVDPNVAQVMLGVIFQTILFLAFGQAALLPAFFAARDIFYKQRGANFFRTLSFVLAQTVTQIPFSVAETIIFGSLIYWISGFVSEVGAFLLFELILIVTNILFASLFFFIAMASPDLHVAEPLSLVCVLAFVLFAGFIIFKTDIPAYFVWIYWINPISWGIRALSINQYMTSAFQVCTYDGVEYCERSGGKKMGQVVLEQYGMPTDTAWIWYCLMYMAVLYVIFVSMSFVALEYFRHEGSHGAHDAHVPASSTDDDESSDDKSTAYEKAPATPPHVQGGAVSIDVTPAQSFIPVTLAFRDLHYFVPNPTKGEPDLELIKGVSGYALPGTVTALMGSSGAGKTTLMDVIAGRKTGGKIAGDILLNGYPATDLAIRRCTGYCEQMDFHSESSTFREAFIFSAMLRQSNDIPTATKLAHAEDCLRLLGMLNIADKIIRGSSVEQMKRLTIGVELAAAPSILFLDEPTSGLDARSAKIIMSGIRKIASTGRTVVCTIHQPSTEVFEMFDSLLLLKRGGETVFYGDLGTNSSHLIDYFMRVPGTLELQPGYNPATWMLENIGAGVEVKQTNDVDWVKVFESSPEYKQLQDAMVIHTQPREGIPELTYVAKRAASSRTQCYYVVQRFFRLYWRSPSYNYTRFMLSIFLAILFGLCYHSVDYTTYSGVTGGVGLIFITTLFVGIISFNSVMPLAVEERASFYRERASQTYNALWYWLGVSLAEIPYVLVNSFVFTVIFYPLVGFKGNFGDVFIYALLVSLFVLMNVYFGLLMAYSMPRLDVAATIGVLINSIFFLFMGFNPPTSAIPSGYRWLSTITPPKYSLAVLVAQIFSKCTDGGRGMGCATMQNVPPVILTQLGKDNVTVKEFTEFMFDMKYDDSGKCVLVILCITVVFLMMVLLALRYVNHQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WN55</accession>
    <name>A0A6G0WN55_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetylgalactosaminide beta-1,3-galactosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.122</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ae201684_013493</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.122" evidence="4"/>
    <dbReference type="EMBL" id="VJMJ01000173">
        <property type="protein sequence ID" value="KAF0728749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WN55"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002435"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016263">
        <property type="term" value="F:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF14">
        <property type="entry name" value="GLYCOPROTEIN-N-ACETYLGALACTOSAMINE 3-BETA-GALACTOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026255620" description="N-acetylgalactosaminide beta-1,3-galactosyltransferase" evidence="12">
        <location>
            <begin position="19"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="13">
        <location>
            <begin position="51"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF0728749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="327" mass="38329" checksum="0A537B1635FDC15A" modified="2020-08-12" version="1">MPRVGYGLLLAACGAVRATRSKAEVCAEDYERSNRVLDLIHVSSDHPIDEPRILCFVNTISTNHATKARAIKDTWGQRCTRLVFLSNATDYDLDAVALDVTADHDHLWQKHKASMQYIWETYRHDFDWFYKADDDAYVIMENLRAFLRSPEIVMQQDIVPLQMGHRFRLTNETIHYYVGDKSLLKEYTNRWPNWWVFNSGGPGVVMNSLYMRLAVESFPKRTCLSDKYSVTLPDDASIAFCMAWNGVFPPNTRDLQGRERWHANHPHGVYYTNPANFPRDVWFNQYHRDIGGIQWKEDCCAPDSIAFHYISPEYMRHMERQLYFCRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WNS2</accession>
    <name>A0A6G0WNS2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_013298</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000170">
        <property type="protein sequence ID" value="KAF0728997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WNS2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005947"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="entry name" value="SCP2 sterol-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051687">
        <property type="entry name" value="Peroxisomal_Beta-Oxidation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45024">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45024:SF2">
        <property type="entry name" value="SCP2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
        <property type="entry name" value="SCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="5">
        <location>
            <begin position="8"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0728997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="414" mass="44873" checksum="7635237E79B565A0" modified="2020-08-12" version="1">MPIRFDGQVAIVTGAAGGLGQAWARELHGRGASCILVDIDPRVLQIEKPSQPTSSTAKWTGVVANCADEKAGRQVVETVLATFGRVDILLHASTQVQDASFRKMTREQWNSVLENDLTSAFTMTRAVWTAMRQQNYGRILLCTSASGLYGNFGQVNYATTKSGVWGLTKALSIEGRKYKIGVNAIAAVAGTTLTQTVMPKDVFDRLKPEYTSPFVVYLCHGSNNENGSIFETGGGWIGKLRLQRSSGVGFPLATSPEVVAAAWDQVVDFSEASYPASTQDSFMPMLQNANYPPTTLKTPHADAVVAVFDRLRSTLARRRQPLRASGVLEWAIGNATFTIDLKTNSVHHGGRSDVGGADLIVTMTEHDFLELAAGTLRLQQAMASNKLKLKGDIKLAMGLRHLLTLFQEQPASKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WNS9</accession>
    <name>A0A6G0WNS9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha-galactosidase</fullName>
            <ecNumber evidence="4">3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Melibiase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_013322</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="4"/>
    <dbReference type="EMBL" id="VJMJ01000170">
        <property type="protein sequence ID" value="KAF0729023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WNS9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001992"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016139">
        <property type="term" value="P:glycoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF14">
        <property type="entry name" value="ALPHA-GALACTOSIDASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026036748" description="Alpha-galactosidase" evidence="5">
        <location>
            <begin position="19"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0729023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="395" mass="43725" checksum="07ACB020321AF339" modified="2020-08-12" version="1">MRLVPWSWLLAVATSSSAPSQPSLMAGWTGYGLYDCSAACSLSESSPSCSSDVFYRRVIDAMVDQGYTKAGYSWLYIEDCWSQDTRDSFGRLQPNSQRFPHGFASLVDYAHHHGLLVALSIDLGPQTCHGLPGSWGHFGMDVHTIASWGFDRIVVETCSELPAPSTAYTMLSTLSSLIHQANLTSHCIVHPDLNATLVHAACDLVQRSPRVQDDWFDVSRQINDLLVHPTAEELIRGPLVVGGYGLTAGQARIQLAVWARHSFPLLLSVDLGMMDSSMKALVLNPFFLQAYRAKRIDTVEFQGKLPPNVLVWTQNVALVDEDHMPALVLIAVRLENRPPHGPLLFDIAWDDLKLPLDSTCRVTNVWKNSTQLDVKRRTTLSIAPFDAEILVLACK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WNV2</accession>
    <name>A0A6G0WNV2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_013337</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000170">
        <property type="protein sequence ID" value="KAF0729038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WNV2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007489"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF214">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="397"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="424"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0729038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="584" mass="64455" checksum="9308F8D6D53F47F0" modified="2020-08-12" version="1">MAAAKCIYEAFPPSINIIAVWRTSLCASASASCFVNRSCVELPKPIYLYDAVGDYSDSPQTSVLSLSTRSLLFARTLQINGRGPAVDWSMFVSPANLTNLTLTHFPQIELSPNFQWPPRLVSLSIVSVDNMTWPNTSQVPRLIELNIDKSSSLPSSFPASVKSLHVLSSNLTEIPSQLPPLLTSLALDGNPITTPPTLLPTLTSLSIASTAITSLDKLDLTNLALLDISSTPFRTITNATFSSKLDFLNLTNVTLENWEMDQATFNAINRNDIPTLGLNESLADVTVTLELSNTICSDSTASYVWKTLCKSKFQSCNDCLGQDPIEDVSSTNYTNIIVGATGGAVVCIGLLIWWICRRRDRIERAVKSPRQMNSTWTDAQTIEMTNLAVFRVPERELELGNLLGAGAFANVWRGTFRGNAVAVKVLQDHRLDHVQAFVDEIQLVGKLKSPSIVKLIGVTWTSPVDLKCILEFMDCGNLRDYLAHHNSQVFPWNDKLPLIYNIIEGLVYLHSLNIIHRHRGIKSRNILLDSTKGTKLTDFGISKEDIQAMMTVGIGTFRWMAPEVIQSQYYTTAADVYSFGVVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WPU2</accession>
    <name>A0A6G0WPU2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_012903</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000164">
        <property type="protein sequence ID" value="KAF0729402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WPU2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019163"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0729402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="358" mass="40977" checksum="23F95A9ACA9140B7" modified="2020-08-12" version="1">MDNPGTTTPDEARRLAETVRKREYRAAKHSELVRLEAQARRLGAYLAQLKREIGTRKLACAKGENMNLRTQVNQFNYLMQIFSQWVHMNEHPQKDLSHRSPWFESTLLAHPIARRQGLKWLSERVYHQARRAVPLNEDVMGISCILPLSQPYRGQIEMVFSFNPHVSDEIDDEGATIAAIETHHQHTLPTDFRSAAAVQWEKIVGTNSTITMKLIERVDDRFVYYHHINHRVGTHTLSIAGIFHEDNRAVLTKCFVVKDELFPHEDGVLRTHGFAWAIYEAVSLGITRVHNFSLQYTPIMANGRVIPLARMGQLFGQSQAGVQHRDAYIERIRSAAEASFIDSYTAVSRELSARDNQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WPX5</accession>
    <name>A0A6G0WPX5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_012915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000164">
        <property type="protein sequence ID" value="KAF0729414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WPX5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018336"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052394">
        <property type="entry name" value="LRR-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0729414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="424" mass="44114" checksum="3C46A3FEFDCF4628" modified="2020-08-12" version="1">MVWGVKRAGVTDLIDKIRAGNTKNMYVLQTRTVSSADAISLAAALETDAVLEEFYLSGHEIDAAAIAAFANVLAKNQVLQKLAVGTSKLGDAGVTLLANGLAQNPSSGLMEWDMEYKGIGNSGAEAMGAMFAVNKNIRRVNLARNGFDGAGLDAIVSGLHASQSVQILDLHDSELTLSHTSAVSDFLCDPKCALETLFLTGNPLGDSAASLCAAIGVNTSLKKLHLDQCSLSEAALVALGDALATNQSLEHLDLSHNQLSAASVAALSRGLQQNRTLKHIVLGQTKLTDAWALELSSSLHVTSLDVSGNALTQTSLVALVQVPSLRELRLFNNALQDGIDAVVPPLVANKTLKTLDVGANGLHEARAAALFSALHGHSSLETLEMGGNNLGDVGFTALQALQEANPRLDVAMDKGAGGGANDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WQC9</accession>
    <name>A0A6G0WQC9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_012879</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000163">
        <property type="protein sequence ID" value="KAF0729614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WQC9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005874"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="441"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0729614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="465" mass="50532" checksum="C2B9638E6CC3826D" modified="2020-08-12" version="1">MYKMLLVGDLGVGKSSLALRFADGTFFESSIATVGVDFKVKTIELEGKTIKLHVSDIAGQERFRGVATNYFHGAHGILVVYDVTDRESFQHVKEWLDEIDQKASEHVNKLLVGNKSDLIAERVVSTDAGKEFADSRRMDFLETSAKSGHNVNEAFTILAAQVKKRLPDQDAAIPQPPPPAPPTSSQSSSRLKNTLNLIASPSYALLKSFPPRTAALSMLATTESGRIELVVEVELSPLQFKFVGKRSISPTAVGSASGEQGVQEAMNLKGDATYKILVVGDSGVGKTCLLLRFADDIYGNHNVSTIGVDFKIGTINLDGDKIKLHVCDTAGQERFRGITNSYYRGAHGIMIVFDVTDMDSFTNVKQWLDEIDIHATDNVVKLLVGNKSDLTAKREVSTDVAADFAKTRGLDFVETSAKSASNVETAFKTIASRIKAHLESDSSSTDDATGLRLDSRRSSSSRRCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WQN2</accession>
    <name>A0A6G0WQN2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_012782</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000162">
        <property type="protein sequence ID" value="KAF0729723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WQN2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013734"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43490">
        <property type="entry name" value="(+)-NEOMENTHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43490:SF99">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0729723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="267" mass="28691" checksum="6ACBF9B4F9BC878F" modified="2020-08-12" version="1" fragment="single">GIGYETVRILSERFKNQAIVLLGTRSLENGKTAISNLKQSNPSFDYANVGLVEIDVTKPDSIQAAVDFVKETYGNVHLLINNAGVAGQAEGAEACFKVNVYGVSATFTAFQPLLVPGDSSHIVVGTKVGAVALGAMSPNLQDIFENFTALDVEILKHLQQDWLLFAQQKPSLGTWPGLDKTYGAYGVTKAMVMALARKWAAEFPEIKTNVVCPGYCATDLTNNGGLLSAAEGAERVLYPVLNPETTETGKFYAESTEHSFKVAQADH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WR61</accession>
    <name>A0A6G0WR61_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_012532</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000159">
        <property type="protein sequence ID" value="KAF0729891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WR61"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005001"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14686">
        <property type="entry name" value="bZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="262"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="293"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="BZIP" evidence="3">
        <location>
            <begin position="135"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0729891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="362" mass="39405" checksum="70CF3039724B4878" modified="2020-08-12" version="1">MADMTPLDMLLIEEDDMHTLFDENPVDIGILDDIPTFKDEVDLISNATTDECSPVSSPSSDYSDSTSSGSPVHKVHTYPVATAYPWMPAVIPTALPLTAKVPFAMPIGVLPPTNKRVLEDTSATQQSKRTKHEIRLMKNRESANKSRLRRKNQVTDLSAENAQLKARLAERDAQLAARDATIKSLMEQLDFLRGLVTNGGATNRATTEDSTTPAANSFDKTKLATPAAGIVLCAFIFGLTLFSDPYANSAPKVAPHRRSMRVVHGMSPAVPVGSNMFVATAPASMLYMLSEYAALFGSMWLTLASVLIVALLCILVMRSPKEQPQVHVNVSLNELGPVHRLCNRASRWVAKTTSSVKLSKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WRV1</accession>
    <name>A0A6G0WRV1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_012204</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000155">
        <property type="protein sequence ID" value="KAF0730199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WRV1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004237"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF57">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0730199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="288" mass="32979" checksum="EAB050FF4A22B712" modified="2020-08-12" version="1">MSIDRRGRHVTSEELDGILFEKIIYERSLKARVKRKMIKAWASDIADDLDQDTPLSFSDGWLEKFMDRYDLTLRRSTRKPVLEDHEIISRCASFVTHTTYTIWMRRLYFFTTQGKQLWILSGPRDVPIVSMGFDKMRVTGVFCASATGRKLKPLLMVKQSELSIRDEGLVSVCGAPKSWMNSTIFIHYLEHTFGLTNPGEILLVFDAARSHISREVKAYLQRKGFLYAVIPGGTTAFAQPAHVSWFKPLKDKMAKNIDEWKSGGVFEYTRGGRPRPPAHGVVAKRLEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WS02</accession>
    <name>A0A6G0WS02_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Centromere protein L</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_012227</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000155">
        <property type="protein sequence ID" value="KAF0730224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WS02"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002417"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0730224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="33494" checksum="443E8A065723F8E0" modified="2020-08-12" version="1">MAVMKDPKTMDEMLVEGTWNIYYVSSLYNFKHDRDALAKDATDLVTFLREADSRELRPNQGVTASVRAKNDLTMFMIHEQVFDVSGNPPQRLGAFVYYSPNHGAATSNPNVTNLLLLQGNEALVAHMCAWIQHRYQCIVALHSVNIQSTSMEQFAQALFLHISTQPPHDDSDTTIHAPLKITLRNESDSKIIRSVTVAIPYRDIQAKHELQRERRNTLVDQDRMIRSLFVPYCTQLSMDMSSFRLSVVSAPDCVLDHRGALSLLRAERAIDILNDVLDIFVVQDVRLPETSDMTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WSE5</accession>
    <name>A0A6G0WSE5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_012105</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EamA transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000154">
        <property type="protein sequence ID" value="KAF0730403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WSE5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005956"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004626">
        <property type="entry name" value="RarD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00688">
        <property type="entry name" value="rarD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911">
        <property type="entry name" value="ACYL-MALONYL CONDENSING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911:SF137">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER G2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="234"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="9">
        <location>
            <begin position="5"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0730403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="324" mass="35682" checksum="ACD66BFCFA8C5A2C" modified="2020-08-12" version="1">MTSKVGITYAVVAAAIYGVYPIYFKQLPDVPPFQLVCHRVVWSFVTLIPVFLWQIDWTAAWRDAAWKPKVLGLYLASGVLIASFWCFLLWGIHHDYIVETSLGGFVNPIFSVLLAVAVLKERLRLLQWVAVALAILGVLVIAIAYGRFPWLAISMGALIAAYGFLKRLAPLGAIEGVVIEMAWLLLPAIVGLIAFERHGTGAFGHVSGTQNALLVLSGIVTVFPLLLLSRSAQLISFTLFGVIQFIYPIINLLVGVFIYHEPFSTSKLTGFVLVWLALSLYTVEGIIAEKQRRSADKDIVMKSNEDCTPQSPTSTFKTIDSPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WSE6</accession>
    <name>A0A6G0WSE6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Isochorismatase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_012343</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000155">
        <property type="protein sequence ID" value="KAF0730347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WSE6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012526"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00431">
        <property type="entry name" value="cysteine_hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF1">
        <property type="entry name" value="ISOCHORISMATASE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA" evidence="6">
        <location>
            <begin position="31"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Isochorismatase-like" evidence="5">
        <location>
            <begin position="303"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="199"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="150"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0730347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="474" mass="51981" checksum="2401042205F022B5" modified="2020-08-12" version="1">MLISFVEVDGHLFYSPLAEFSSTYETPRLEGNLVVADPITAAMPLKNAKQVNGNIVLVQRGDCDFLTKTIHAQKAGALAVVVANSDEENPQLAFVMDAGQSRSKVSAKIPAVMAPFATAQHILDLIGQTNQMKLTVAIVLLDATDASAVLDSQERERQRRLREEDALRKQLEREKKQREAAILLRSRLVKDIQAKDNFDQGLSDARPPPLPSSPKQQFVPKQPLGSNQPATALPPPEAINLSVINVSHAVPEAIAHANSCIPEKLSATGLLVLDVQYYCAMPHVGKYANMEVLNDYYFDRIKRTMVPNIQSLLFALRQRSMEIVYGIIESATKNGRDRSKAHKLAGIHVPKQSFDAKVLESVSPTDYDIVIPRTAISLFSTTNADYIFRNLGLECLVVVGVSTLGSLEMAVRDALDRGYSAIVVEDAVAFDSSDEHATVMRSVDKMGGFVVQTRDFLLELQAKCAPKIVEAVSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WU86</accession>
    <name>A0A6G0WU86_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_011617</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000147">
        <property type="protein sequence ID" value="KAF0731069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WU86"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019600"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0731069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="777" mass="85710" checksum="84CA5A3A34704CCA" modified="2020-08-12" version="1">MDVTEAEDSRPKLVQSKSSTAIDIQDQPQPELESLPSSSSSSGFDDDDETSDDEEGSAKRSGECESLLENSPKPTCLAEQLWEPFRTLVMNPLSTFVVFSAINSIFVLIWAMFEWIASLITKPGLFMLVIASIVCLARFTALLLAYPGHLRIVTRDCERNFAKMCKRWLTVTTDTADQLVDFLQSPEALTPSRLGALISLRDEYRSCVESIVEVLRRSLELVDSEETLSIDGQLLLSRVRVFLKYSEALNTPLRQFISRGRTIGPPPPSFLEPPLSTTILEFKSCIQDLRDAIDLCGEKASTPKRQGIVRLICELWQSRWPFQIVANLSLMRADLIVRYHGRQVWVESADGHAIDGMFIPGQGLSHENNTGRTVLLCNPNCGLYEFHHFQSDWIQFYTKFGINVFVFNYRGYGRCKGYPSPHANNMDGMAIIEHLKSRGITRIAVHGESIGGMVATHVARHAGPVVELLIADRTFANLPAVAQRLVASWAGSALSLVTRWQTDNVSNYLDAPCNKLVCCDPSDEIIADASSLKAGIALRLELGDMTLGSPTESEPPSLLAPCASPHSAQRQIESTELVPGMPLNEAIVTRFATALQSIGERASLTMVSSAGDVEIGIGERHIVDIWTAVVSIDGYCGQTLYYATGGGLEGIRTWIASFLVWGSTLSQSQASSQNDKGAMAKHTELVTPLSIDNVVIVLRRILTEVPDVQNDEDVAYVLRVVEYLKASLDSRQRSTPPSIGQLVPLSCGHNANFSEHEKQVLVRHLVSFNWIDPSQVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WUN6</accession>
    <name>A0A6G0WUN6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_011489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000146">
        <property type="protein sequence ID" value="KAF0731229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WUN6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011608"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0731229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="480" mass="53625" checksum="4C398C50BB27679E" modified="2020-08-12" version="1">MTRRPTNFVENHRPYVVSNQMQHKKRHQVMRYRKKVPDPPLSPVGNNFQDDESDTASPDNQSSHESSPVKVHPIPTSSNVYVVNVQDFRFHPEHIVIERYSTIRWQIPADSNTVYSITISSAHSTNSPTLSQDNPTFEHTFDTLGTYAYSCSLYSFMNGTITVVATLSAEEMSRNMCFLDYPLPKKPSKILSPTSLAMYPFQKQLVVWREKQAPRESHEDDDTFAKKSRERIKKKAQKVAMNGLKPKPISTPTIETTTESLPELDNASLVEPVAPSVPCTHQVRIEDFAFSALPSRPVVGDTISWHVSSDSPGMVEHALRLRVVSHDGAVEQTLQSSTLKPGDHWSCLVLQPCTLYVECDVYHIKSEVVVAAPTPVILIGDVACPVDDASISTPSSPLSKPASPVVADSTDQPQPSIIQLFHKSKLKQKAMRSSYLIPDKERAKTGLIGFDAAATYDFLKRRAQEIKQDVHVVYACCRQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WUU6</accession>
    <name>A0A6G0WUU6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_011362</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000144">
        <property type="protein sequence ID" value="KAF0731298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WUU6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006299"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="8">
        <location>
            <begin position="667"/>
            <end position="828"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0731298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1077" mass="121491" checksum="189E319071674370" modified="2020-08-12" version="1">MCLPRPQPLDQQKIHVRNILDGKLEVAWQNGMDPVAHAKLTSLLTKFEDVFRIEIGRDPPVKVPPMVVKLKPGATPVKCGARRYSLNHREFMKTHMEEFCEAGLMYRNDSSAWASPPYIVAKPGTNKACSVANARYRSGDGKSGWFHLLCCPGFLQRLLAVPLDPSCRELYTIMTDFGCYTSNRIPTGGSGSLAYCQATVTNMFKSLLYKCLLVWIDDLLVYAKTHSDLMNCFEEVLSICSETGLKLNPDKCEFFATELKWCGKLVSGSGVRHDPGRIAALQSMSLPRTGADLMQFLCAVNWMRSHIPRYNEVVAPLMAALQRVHSQSGLKTKKKLEKFVLPADFFSDAEKTNYDHIKEQLSSSVKLAHHDPSKMVCVFPDASLRFWGAIVTQVPMNQLSLSIDSQDHEPLAFLSGPFRGSQMAWSIIEKEAFSIVETCKRMDFLLLRPNGFKLYTDHRNLTFLYDPHSCSRDIARYTAEKVQRWGLVMMGFNYTIHHIDGEDNVWADLLSRWGAQHIPPSVQALHVIPSNPSPLLDEDFVWPSVDEIIALQDKALVEHPQLVEKDPTCPDVLTTHRPYCSSEGRMWIPSCDPGSNTITNIKIRIMVLGHCGTAGHRGLEMTLKAVSERFTWCDLIEDVKLFCSQCFHCQKSASGTMVPVPLGSQIHASRPNEVLHFDFLYMGPSDTGDMYVCILKDDHSMCLQGTNHPSADSDAACFALHSWFNWFGIVRTWISDQGSHFKNRCVAEMQRVYGAHHHFTLPGCPWANGSIEIVNKHFLKLVRCLLAEWKLPHTSWPRVTSKAIKILNHSPSRLLKGLAPITVFCNLPPCLPLNGICHPDTFTPIPPEEFDAFLASRYDGLEALQQSIYDMHSDLAAHKDKIRSQKRAQKNRGAVPQQFSIGDFVLVLKKSTSVPKTLYMWDGPWIITRTISNWTHTEMAHWSYPESFLILSSFCSVGNEVKKIVDARFNLVAKMYECQVVWLGMEDDTTWEPARHLYEDVFTLFKEFVLMKSSSTGEGHPEFALYKAMQIEFPLDGNAPTQHGKLKKSRKKGPSVRAIFAGKLPFKTQAGLLKRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WV82</accession>
    <name>A0A6G0WV82_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_011289</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000143">
        <property type="protein sequence ID" value="KAF0731386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WV82"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009065"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006912">
        <property type="entry name" value="Harbinger_derived_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47150:SF5">
        <property type="entry name" value="OS07G0546750 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47150">
        <property type="entry name" value="OS12G0169200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04827">
        <property type="entry name" value="Plant_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0731386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="27618" checksum="36E9D79848FA465F" modified="2020-08-12" version="1">MAVLARNAMDSSDDQVVMALVQVIRSRQVKTTREARKSGNIGRGHLAGHENIIRDYFGQGNNPPIYSDRTFRRRFRMGRDLFLRIVHSVVEDDSYFVQKRDAIGKKGLSHIQKCTSAMRILAYGLSADATDEYCRLGESTSMKSLKRFVDAIVNVFGPKYLREPSDDDIQHHLNQNAARGFPGMFGSIDCTHWEWKNCPVAWQGQYQDREGKRSIILEAIATQMARVYWCPRVKQRYQRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WVX3</accession>
    <name>A0A6G0WVX3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_010999</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000140">
        <property type="protein sequence ID" value="KAF0731695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WVX3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003545"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019074"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030692">
        <property type="term" value="C:Noc4p-Nop14p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007276">
        <property type="entry name" value="Nop14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23183">
        <property type="entry name" value="NOP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23183:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04147">
        <property type="entry name" value="Nop14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Cyclin C-terminal" evidence="10">
        <location>
            <begin position="60"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="9">
        <location>
            <begin position="64"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="514"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1083"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1010"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="456"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="514"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="585"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="596"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0731695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1109" mass="125810" checksum="118A6E199A542C7D" modified="2020-08-12" version="1">MMCERGRLGRLNVLSDSGHISTPPTWNEREEDLLTPPDCGHISTPPRWSRQEEDLQLAGTHVYHFLERFIQAGCATETQQHFAHYLAELAVMDYPITIAHPPSVLAASIVYMTRVVAKEKSPWTPTLHHLTTYTAEQVRDCVAKLYKIHDAEYQVLKTDPEKIRAVTDKYISVKYARVSKLPPVQPVDADVESESYRQDGPSPPVEIGVCWTTTNFNKGLGTKRAHDELGGPQVPKKRHVVASGSAKRAHDWDDELKAVGRTKSKGLKAAFGKGKGNAFDVQKNSKSKYEVLGKRVKGQGRNVAQARAEAEERRRKTLLKQFQGRKKNNEFKDRRLGEQNEEMSLEDKMIARFQTERKRQYQQRNAAKFNLNDDDDDQSEDDLLTHRGAKIDDFDNIDIAGSDDEPDDAFDHKMGRDIVNKLHFGGGGNDAKDGTEKKKTHEEIMQEVMMKSKMYKAEKQKNKASQDETTEALDAGFAEFQSLLQFRPKKEDRPREAPDDFDKMARELALEAKAKATERKLTPEEIAKREHEKLADLERKRVARMNGQDEAESDAPQKKAKKKQPELVMLPPKRATDDSLVDDYQINQEFNQAGSEDGDDDDEEAGDEDDEEGDEEDDEDEGDDEEDEEEEEEDDEEQEDGDNADDKDEDDDDEDDEEDEEARSVALKRREEAAKEMPYVLPCPEVPADLTNLFNQYGHTAQDRNTIIDRIRKYYSPKVSAENQTKMKKFLAMLVRYFLKMASNFKHNHQDADNLAAHIFSMAQEMPNVAGTVFREFIATLAKKMDKKDATYPDMRELLLLRVACNVFPVTDLRHNVVTPIELILGQCLAKASLSNVDQARKALFCCGLSLHITEKKAKFMPEVVHCLKQLVQLVHAQEDNANAWFVDAIKAFIKANSASSTTSLPKLPLTETLSEADMAAAVFQATLALVETAATQYASLAAYHELFLSLQELLSQIKAKVLKTACASTLTLLEAKSKASLDSRRPLRLQAHAPKVLPTFVPKFDENYAMRKDKTLDRDKAQLKQLQRQVKRERKGASRELRRDAAFLSRQRTEEQKAWRAEKDAKQKEIRAWMEEQNATFNQQVRKGGELIKGGGSAPAKKRRISKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WXE3</accession>
    <name>A0A6G0WXE3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_010541</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000135">
        <property type="protein sequence ID" value="KAF0732249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WXE3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004859"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000057">
        <property type="entry name" value="Cyclin N-terminal domain containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="5">
        <location>
            <begin position="60"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="5">
        <location>
            <begin position="158"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0732249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="281" mass="30742" checksum="F4B7D75203992710" modified="2020-08-12" version="1">MDLICHEEEGVVADELMYNHIPDMLESLLKREDAHRPDSDYVTKTQRDGVNASTRSRVVAWISEVAGELRFAIDTIELALNYLDRFLSTTSITKRELQLVGLVALLVASKFHEPDSLLAAEASEMAQAAGFSASAIHDMETRMLAALQWQLHVVLPIHFVDCFISDLELPSLESSCHTLLSAAHLSMAMVAFHPSQVAAAVVSVSAQLNGLSSSLVSSYLETVGIEAPRACQRLLLHNLPLKRERSPSPTGVEELFETPVEFVATPSIAAVCPVAKRPKLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WYI9</accession>
    <name>A0A6G0WYI9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_010293</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000130">
        <property type="protein sequence ID" value="KAF0732585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WYI9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011643"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="65"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0732585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="228" mass="25237" checksum="949D15DD7F0D87FF" modified="2020-08-12" version="1">MASPDDKTKPGDTADDRADGAPAKATDHMKEALSKMYGLTAIVTRVTRDLRQVERAAEKMEAGHARVSQDKAAQLEDANDKLTRQNASQADTLSKMQAEGAKQAARIKALEDELAITKKLAVRSEKVGRIRSERDDLRREVVRLRNERVGFGHRYLNWGIRKNLVSDTRNADLSVRAWLHEEGILDDPGSVSQWQATTGYTLIPNEADPTSIPFTLPCGSESKSPRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X0Z3</accession>
    <name>A0A6G0X0Z3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Threonylcarbamoyl-AMP synthase</fullName>
            <shortName evidence="13">TC-AMP synthase</shortName>
            <ecNumber evidence="3 13">2.7.7.87</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 13">L-threonylcarbamoyladenylate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Ae201684_009702</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:36407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="EC" id="2.7.7.87"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the SUA5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.87" evidence="3 13"/>
    <dbReference type="EMBL" id="VJMJ01000122">
        <property type="protein sequence ID" value="KAF0733457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X0Z3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012399"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061710">
        <property type="term" value="F:L-threonylcarbamoyladenylate synthase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.870.10:FF:000009">
        <property type="entry name" value="Threonylcarbamoyl-AMP synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11030">
        <property type="entry name" value="Threonylcarbamoyl-AMP synthase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="Sua5-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038385">
        <property type="entry name" value="Sua5/YwlC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005145">
        <property type="entry name" value="Sua5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010923">
        <property type="entry name" value="T(6)A37_SUA5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050156">
        <property type="entry name" value="TC-AMP_synthase_SUA5"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00057">
        <property type="entry name" value="L-threonylcarbamoyladenylate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490">
        <property type="entry name" value="SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490:SF16">
        <property type="entry name" value="THREONYLCARBAMOYL-AMP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03481">
        <property type="entry name" value="Sua5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004930">
        <property type="entry name" value="Tln_factor_SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="YrdC-like" evidence="15">
        <location>
            <begin position="7"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR004930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR004930-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF0733457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="359" mass="38359" checksum="2AD705A77BADB69E" modified="2020-08-12" version="1">MLLSPTVEGLKRAGEELRSGRLVAFPTETVYGLGANALDAPAVLSIFEAKGRPLTDPLIVHVPTVQDALSLVQLDDKGTQIFQTLARAFWPGPLTLIATAVDALPREVSANTGFVGIRIPNHPIAQAMLREAKVPVAAPSANRFGHVSPTSAQHVLNDLGHYHKGLHVIDDAEHSSCEVGIESTVAKLEPSLNQLLIFRRGGVSEAALHQVLNVEHQLGIDIVYAQKVVKESDEAAAVGQVAPGQLLTHYAPDVETFMLQGAVGRNVAPTDDMKSWVIVDFHGRVSALKDSVAGYLDLSPTGDIPAAAHNVFDALRWAELVPNAQRILIPDVSDVAHEHAAALHDRLYRAASGKRASLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X131</accession>
    <name>A0A6G0X131_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Leucine-rich repeat-containing N-terminal plant-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_009718</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000122">
        <property type="protein sequence ID" value="KAF0733478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X131"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012413"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366:SF96">
        <property type="entry name" value="LEUCINE RICH REPEAT CONTAINING 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026091434" description="Leucine-rich repeat-containing N-terminal plant-type domain-containing protein" evidence="4">
        <location>
            <begin position="17"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0733478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="33333" checksum="06D7EE466B6566E3" modified="2020-08-12" version="1">MLGRLFGCCIYSGVVAAYTLSTDCPLAGNKTAAACLVDNQGLVSFSFANVTPVLSLPNRNITFVDDFPNESLIIDLSYNSITSLPWRAGTQADVVSLDLSHNALSDGSGVYIPHSVNYLNLSYNAIKRLDQDSFHLSDKLTKLHLQHNGMTEIVNVTFPSSLTELDLSDNPLQFIWLSADAFVKLKALGSKLRLKMTNMAVYSLYGRCTDGRINRLDEGLVCVFGNAASGSTVFEVSALNANNLLRNLMIIVAVLSGVLGVVFLVLWVRRIRTDNTHRGTFSSSACLSFSEEPPQFRALLTPRQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X199</accession>
    <name>A0A6G0X199_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dethiobiotin synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_009782</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000122">
        <property type="protein sequence ID" value="KAF0733548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X199"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019226"/>
    <dbReference type="UniPathway" id="UPA00078"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004015">
        <property type="term" value="F:adenosylmethionine-8-amino-7-oxononanoate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004141">
        <property type="term" value="F:dethiobiotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03109">
        <property type="entry name" value="DTBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00336">
        <property type="entry name" value="BioD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004472">
        <property type="entry name" value="DTB_synth_BioD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00347">
        <property type="entry name" value="bioD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42684">
        <property type="entry name" value="ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42684:SF3">
        <property type="entry name" value="ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13500">
        <property type="entry name" value="AAA_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0733548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="764" mass="82385" checksum="067C752762796BC1" modified="2020-08-12" version="1">MLGLHRSSRRCLSSRAGLLHVGCNIPANGRDPSSQSIPNAAPLSLKLPVVQVFGSNTDVGKTLVSTGLCRAAVKSSATSNVGYIKPLQTGGDSMMDARFLRSHVEDVSRLTCQTLFSWETPVSPHLAAQLEGKKLTDDALVKRVSQAIATTDASTLLVVETAGGVCSPSASGKFQCDVYRPLRLPAVLVGDGKLGGISTTMSALDSLLLRGYDVPAIVLIEQDELDNAEAIRGRASELNIPVFALEKIPPLPTPLNDWYTAHDVTFQSILESIVDYHGNRVARLDSVAAKAKEILWWPFTQHEQNKSVLVIDSAFGDAFATYNNDSKSIEPMFDACASWWTQGIGHGNPKAALAVATTAARYGHVMFPENAHEPAVQLSEALLSTVGHGWAKRVFFSDDGSTAVEVAIKMAFRKYAVDHNLPFDFSHTKQEPIVLAQTNCYHGDTLGVMDVAEPSVYNRSQHPWYKPRALFAAPPTVAIAPSSNGYAISWPEDASLHETLPSLAALFDPARDSTPTAELYAKYVENLLENHVPAQSTVAALVLEPVLIGAGGMHFVDPLFQRTMVHVCRKRQIPVVFDEVFSGLWRLGAQSARDLLHVDPDIACYAKLLTGGVVPLATTLATDQVFQAFYSDAKADALLHGHSFTANPVGCAAALTALDMYKTLAVPSDAPVREYWDATLVHELASHPTIARAFQLGTVVAFELDAATKGYEATISQNHVARLRTQGIYARALGSVMYIMCSPLSSPETCRSILTTVASVLKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X1U4</accession>
    <name>A0A6G0X1U4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Smr domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_009335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000119">
        <property type="protein sequence ID" value="KAF0733765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X1U4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000578"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052772">
        <property type="entry name" value="Endo/PolyKinase_Domain-Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535:SF1">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smr" evidence="1">
        <location>
            <begin position="378"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0733765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="454" mass="51345" checksum="E16457AC96B6EFF0" modified="2020-08-12" version="1">MDTASGMIETLSDMVNYDLSEDEIQLVLVKNDGDMSKALDELLSILAIREMEQTQAATKQDSAMQWQLFTNELESYGLDQDASRELIKLLHERKEMSSVLELLDDVIDDINEHPLQELQKRHPKIPMDIIQEAFEQHNYDLKATADALVETKRLINENGSIETFSYASVAKGKPAKQPAPPPPPLVDNKHEFPTLKRFQLGSSQDEASSVWSKATQGLPTGGRGTLTTKMKLEQLQRSFPTIDKDILCAALLMSDSSMVAAEAMLESTFPSACVKPKFHVEVVDDEPVEEIPDDTSAWTETHHDFASLQAQTKILQEEMQVLHTEAMNKFAGKHNHFLGRERMKRLADVRRELKAVRTHAAYAFFCEIQEKLLTEQPVDLHGLYVQEAYQVLDHCLTFCRENKISKFTLVTGIGNHYHQRSGRMFMTFPVALTRRGIVFVQEGGHLIIHPSQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X1Y2</accession>
    <name>A0A6G0X1Y2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Histidine acid phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_009431</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000119">
        <property type="protein sequence ID" value="KAF0733873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X1Y2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009562"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF110">
        <property type="entry name" value="2-PHOSPHOXYLOSE PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="554"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="418"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="492"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="492"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0733873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="587" mass="65984" checksum="F12FF6B8739993EA" modified="2020-08-12" version="1">MDVASSQEVDLSKKHHKKTQHHNEEHERKHHGHSDSSLKILVSLSRHGSRRPNGITSVLCPNNKENALAYEVPPEELTEIGMEQMRLAGREVRHEYIDNQGFLSNSISGPERKHFETYFRSDAANRCAQSAISMGYGLYPEGTGPRGFYHQPIAVYMELLKDEHEFAAPKGPCKAVLKADIKTYLDTRAQELIEEHRPMLEKVGELCGVSVWDIPNLPDGEDIVMGIKDIADTFTFDTQQGLHRMKGLTPELQSEIEGLAFQNLMERYYSTNREITYWVGGFPTLLLKNLQIPPPEKAEKSFKYYSYHGHRELLHGMGMLLGWKFDFKGQPRAMNNTALDPATTLFFELHEVNTTQFIRTFVWSPRHPRSAVKLEKCSSLDCPLAEFTSIIQNHIRQTGTWEEICNYQKATFAPVLQPTTSPITTDAPEVAQTTEKPKETTARPVETTVTTTLKPATTHETTTKPLETTKEPVPVTTEAKTTPVVITTTAPTTTKATEPPTTTVKPLETLPPTTSVETSPITTFAPVTTTAPPALRLVKLDTIQQQPPLSLFEGLGWASYLAVVGVLVYFAAKRYNRRQQTGYRRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X2C5</accession>
    <name>A0A6G0X2C5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_009222</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000118">
        <property type="protein sequence ID" value="KAF0734050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X2C5"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0734050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="114" mass="12280" checksum="FE3940363F37F1E9" modified="2020-08-12" version="1">MASHFRKSSIFSQFTHLLQLNHAHFSNHGVIASSSIFCCVLALAGGASEDNGGTEESIVKNLSLQNDQISFASIVIALTETPNSVDAIWDLVVCMDGPSIQATHDKAMTRKCIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X3G4</accession>
    <name>A0A6G0X3G4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_008923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000114">
        <property type="protein sequence ID" value="KAF0734464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X3G4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001760"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564:SF1">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="136"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0734464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="345" mass="40803" checksum="C87CE3948B060EAB" modified="2020-08-12" version="1">MILQQVKHQHASRNTVMHALFMYYFLGLQRTKIARLLCKSLSTVSNWIERYETSADYYRRQTAALKHINEEQQEWIVDFYKQNPVAFLDEAKKAFELRFKKYISILERSAMQVRQDDVFSFFHELASINWSYHNIEFLDEVSFDSRGMLRKRGYAIKGRKLCFRGEFDRKPRVSMLCFIDVNGMVQVFDTIGTFDRHKFVKYCAIHAKQCSVYPGKSSIWILDGASIHCHADIVYSLRSLGIIPIFLPAYCPFYNPIEYVFGLIKKAFRRHYKESETRDLMHFVMSIMKKFQNYDLSRIYHHCGYTCQGRFRHDKQLSGIHEAPSANELDNLLDFIDSDEQNETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X3N0</accession>
    <name>A0A6G0X3N0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_008882</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000114">
        <property type="protein sequence ID" value="KAF0734422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X3N0"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0734422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="97" mass="10921" checksum="476C6CEA58BB926C" modified="2020-08-12" version="1">MDWLASPALRNVGTFGIREINRIQEFKRRCAQCSVADPPQLPCLQNVDRRQAKVMGKHAQTSSPSMQTSSALLLGWCGFHRRCKTSKRAESIFNRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X3T7</accession>
    <name>A0A6G0X3T7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_008912</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000114">
        <property type="protein sequence ID" value="KAF0734453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X3T7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011016"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="21"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0734453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="202" mass="22595" checksum="E1A08373975F8B38" modified="2020-08-12" version="1">MDVRSALQSVYENRSTALEVSDVAGMRALFAYIDTNRDGTLSAKQALCIFQLLGLSAHEEHVYELEQMSFPEFISIVDHHTKIATADPTLHSWNTINHFRNDYVSRDQLACFLVNCDGKQVPPAHLDRFLELYGISNELDPHLGELEETGYLKLLDDYKDDDAVEKGNRRRHAVKNLSVPPPLQVTSLEPAQGDSVDAGNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X4L5</accession>
    <name>A0A6G0X4L5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_008498</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000103">
        <property type="protein sequence ID" value="KAF0734834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X4L5"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0734834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="109" mass="11590" checksum="1E78CA92C9F369D5" modified="2020-08-12" version="1">MVLTRRLSSTRHAAWVSGASDDTFLPKNRVEGGRSVEGWRRWESLVMLTGWRRGWMCGPPTGRQAGAAWSSVGLLAALASGASLRGATRNVCACVLSGKLKTFPSSLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X4S5</accession>
    <name>A0A6G0X4S5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_008638</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lipid droplet</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. LDAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000106">
        <property type="protein sequence ID" value="KAF0734789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X4S5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001502"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019363">
        <property type="entry name" value="LDAH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13390">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13390:SF0">
        <property type="entry name" value="LIPID DROPLET-ASSOCIATED HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10230">
        <property type="entry name" value="LIDHydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0734789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="38306" checksum="96B5064A6A9889E4" modified="2020-08-12" version="1">MAAAVESIRLTVLEDPRVAGALVVGLIMLTWLILRHFSKASTSRLHLNDLARVECLSTGRLMHKIVLPPREASNTKTLVLMIPGNPGVPGFYEPFMRHMHQLSGQDVEIVGLSHTGHSLPWINNDETFDLETQVVDKLAYIQKRLERDSSLRLVLIGHSIGGHIALRLLNHYSAQIDKLVLIQPTLMHIGDTPNGKRLTPIFNRYSLVSSVVGKPIGMLPTSLKKLLVPFFVGPAAFHKPALSLVEYAVLLNCLKMAWHEVQELKEIDDGLVKTHQEKMLFVFAEYDGWCPPEQVEILQSRYTQAKHVTVALPHAFMLGENGSEVMGNLVWEWLSAEKMPTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X5A5</accession>
    <name>A0A6G0X5A5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_008460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000102">
        <property type="protein sequence ID" value="KAF0734987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X5A5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000087"/>
    <dbReference type="OrthoDB" id="166018at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38899">
        <property type="entry name" value="DOMAIN OOKINETE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38899:SF1">
        <property type="entry name" value="PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0734987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="248" mass="27683" checksum="B06B3D8875CA99A5" modified="2020-08-12" version="1">MEYFERRFIAPSVETNPFGAIAQMSPLCQADGERTIAVFDWDDTLCPSSWLNAQGLLPLYRGHVVPLNSMVRQVLSALEERIFALLTKAMSYGPVFVVTAAEKGWVEAASTMYMPTISALFKKSNDIHVVSARSWFETTFGCGGDARHWKIEVLGLIASKCFGNRHGLGSFNLISVGDSLAERDACHAAVSAIPETELFAKSLTFIEYPDAQEIFQQIDLACSYFDHMCAWNNHLDLRITRDQLHALH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X5Z1</accession>
    <name>A0A6G0X5Z1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_008100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000098">
        <property type="protein sequence ID" value="KAF0735410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X5Z1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010285"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0735410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="563" mass="63774" checksum="D7543414B35449D6" modified="2020-08-12" version="1">MAAATHFQAEFFHVQCEKSTDLFSGTYVRRYTNQGCNVVRCFPHCCPHTEYRGCGSSISLRLISPSTGNLTTLQAFAAFQPCSVPQMQTGDVVSASIFADRRSASHYKGEWLQGRLDGSTNPPCFHFNEKRTEGWHYGWKGGASAQQRLESHHLCVYVVEPINENPSTFRVVGCACSTPFLLGSYRRAIFAPRRSNRATTRARPPSTPRPSNSEIINALLSYCQSLSICDFQSEWRQLEQNLMAGYQEWFGIEVNHTHLVHFEENHPTSVSAHSSGPREAAMRLLAWWAGPPTQYAVYTQFQQLWGGNSSQEIAAAHEMWNDFLAQALIQVNPQVLDSFARDRGRFLGTHSRRPELNFVTRILQHQMCQVVSPPLKDNSFSGQWVLEPHRSYMSIKASMSPSFLLMSEVLTMALGLRINLVRDALHVQSCIQRLPTNPQPLVLDSVPRLLRTLPNGEPGSIIDTNLFVGDYLGWIENRGLLLWFYGWPKNATNVRYVLQVQASMQGKNHLEMICTLESSEIERPIDFEAMTSEERIFRTDTTTLTTALNATLCYRRHVFDINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X617</accession>
    <name>A0A6G0X617_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_008086</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000098">
        <property type="protein sequence ID" value="KAF0735395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X617"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013198"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15710">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PRAJA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15710:SF74">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="76"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0735395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="210" mass="23360" checksum="6235656CF3C880B7" modified="2020-08-12" version="1">MSVVHEVSSSGINVRLSVSYPVPDHYKVSDVLAVFRSAPWVHVMVGHVVPYLKSSSPAKKEVLQTLIPVPCDDEECVICMAAMELSVALACGHHFHLDCITTWLSQRSTCPTCRFQYQNEFSGRYAFKAIDSALVWHSDDEDDDNEEESTLYAIDLGGQVVQVTVHVALMHLQHAPNIEKYPCVLKAGILREHTAKGSTLERRPTRGVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X6G5</accession>
    <name>A0A6G0X6G5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_008039</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000096">
        <property type="protein sequence ID" value="KAF0735471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X6G5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017875"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33223">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33223:SF6">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrotransposon gag" evidence="2">
        <location>
            <begin position="216"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0735471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="478" mass="53636" checksum="96841450648DB443" modified="2020-08-12" version="1">MVKPSDPAKLSADASADNQTSTPVGMHLDPSKQAKQAAAASRSRFGQTPTASGRYEPVAAPTHATTTNPDVQSRSGRNNPAESHSYGSDDDDNDASAFPDSADAQSKLIAELARQNQYLTEQLQSRQFPMQAHEEDDDDDLDEWNLDAAPVGLSSNNGPRLHVLALEPLQRFSGSVDGTDAASNFLRRFEENAAASGWTDDEAKRKFRLTVGRTVQDWYNQLRADERSTWKALRASFVREYILSPVPKQEVYYTMRQKENETIREYLFRFNAAATKIGLKYDTVRKHFVDHLRCFCNSLADPSQAKWISSMRFASMDDLKEYLNDQRHTEALREHRSQRGATQAGNNQRQERTKAPRVNHLDAVTPTDMAKLAAAATDSVRAEIFALGLNNYEARREVCRDCGKTHFKLDGLCWSTVFCTLCQRMEHPEINCFKACQLCATPHHKADPCPTRQQAAELKEFLQGLDIPDMPSLDCLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X773</accession>
    <name>A0A6G0X773_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Putative sensor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_007871</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000093">
        <property type="protein sequence ID" value="KAF0735869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X773"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006946"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025828">
        <property type="entry name" value="Put_sensor_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13796">
        <property type="entry name" value="Sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="347"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Putative sensor" evidence="3">
        <location>
            <begin position="84"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0735869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="424" mass="47615" checksum="60ABB736226F849B" modified="2020-08-12" version="1">MSATPSKAPRHVPMYRPNETTPVVQVIPQATYVQPQPYYAPPPPPAPLPPQQQPKQRKEKHRFWKAITSPIQPKTFQLIVFHLINLFFAIVAFSIVLTLGLLGIGLIPLFCLGIVILQVLLYTVHFFAQCDAYLYNCVAPNDAQITVQFDIPRRGLYHFSGYRIAPDLSRFSKEGGMAIFYFIFVKFPLALIFSSIVLTLLAMSIALIAIPFVDKNYIQIDQQTWRDHDLKFIHHLHVEKWTPTGFVVRGVILLYITILLMHIFARIHRYATKFFTCEFFATSGVLTEGTAVLPQYAPVPTAPLATTYATAPLYEAYPAAAPVAAPVATAVPLRSSRTAFERYASKFGYVLLLAVLSFINLLFSIGMFVVVMIAMSLTIGLLPVACTGLLILYLLAVFAKPLSAADTWLYEQRRHVYSEIVRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X9J2</accession>
    <name>A0A6G0X9J2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_007091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000088">
        <property type="protein sequence ID" value="KAF0736641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X9J2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018311"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="741"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="223"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="755"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="803"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0736641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="820" mass="91213" checksum="66B3672EB68E9399" modified="2020-08-12" version="1">MAKQRRKDSDDIIIKVPLKTTKKKKAKTMLLVQGKPSVIRAVQQTGKIKSVTVRKISSSPAKQAIQKTPPTPVQAKRPTVVQQKSKIVKSSVTVPKISSSPAKQAVQKTPPTPVQARRSTVVQQKSKIVKSSPIAPTPKMRNMDLQTETKPPSLEQAVQFMQKHIGKSDESDSESENDSSSKNFPGPVAKIALKDLSSDDEMDEQQKKLSSSTKQASKDSIKKTPATKASTTTIKRSAPGAGAEDIIKKRQRHSLLDDPLQDLNSKDEKISIKMGKTPKPINASLQTPSPALKKIKGKLSTPLASNNHENDSESDMEARPMTSKPTQKRLTTANVSDSDDEAEEYSEGITTRAKQPPKLKEGKLTPKQAITKGQMETKPTTQAVNTQKLSDKPLQEKVLSKENAAMKVSESNHGKTPVKVSTKTAKLMPRDAAKPKKVKQQPKTKVLNQSQMSGPPSSPVPENKGNLEDAVKFMQKQFESHVENPDEVQDSQTLPKAGKLTFMNTLIDHAAADQWNLVEMGRLIRLFCFQWNCKRKKTTRFLRRNCAEFVCADFLEGLNIQLKVGQLIQLMRRGSASLSVLSSKLSACIEADILRISDDELLTSLGDIVDIATMTQDEIAEFLTPLIESCNKMDDACKLLHRVCEYWPIDTMQTFVQRVLLLNPVFDDLEGDPADISNYFPNCQFDLPNRMLRDLEDMDGSGNLKDFCVGEREEDIEYEVRSSADELEALEDKIQLKHGKKRLKKLSTPSNKTDDPDDESDDSEDSVDDEVDAVPVVESDDEDDGHWRQGPQPRRRSIYVLDEASEEEDYESSDQGSEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X9Q0</accession>
    <name>A0A6G0X9Q0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_006959</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000087">
        <property type="protein sequence ID" value="KAF0736802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015312"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000904">
        <property type="entry name" value="ABC transporter A family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000298">
        <property type="entry name" value="ATP-binding cassette sub-family A member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF36">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="459"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="492"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="525"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1052"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1243"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1308"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1340"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1374"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1453"/>
            <end position="1474"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="679"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1517"/>
            <end position="1750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0736802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1932" mass="212922" checksum="DAB847C426E3267F" modified="2020-08-12" version="1">MESQQDPPQRRGYIGTLLWKNILIKKRHPIKWALEILIPVALIALMGYLKTLTDDVKVPDGWSTDDVVHKHDKNGTSYSLFSPQYSSRGIDIPRFYQTEGTVSGLLLQMATKTWSDRKGAEGMTAEQNTICATAAFAGNVSADVNSPYAWPTACRDNLIPRKLAIAPDNDFTRKYFLETLNVWYPRVALNANQTFVIPSIADSVKFFADESSLESYITGGDYGKSFSSPVIAAAIVFTAAPSKFGSVGDIEYHLRLNSTRGRGGITGDIPRTNIKAFQPLQRSIQTESYTRYAMSGFMSYQTLVTRFALCVPDWNADTQTTSGNCTQEKAVMTSTVASDITLVTSQLQNDLNLLMSVASYMQATKATFNLTDVPFSSLSALAKPLRQMPQPVGGATVFPFPIKEYISSPFFDSVKDTFGLVFIISYLHALSSVLVALISEKETKARELMKILGVRDSAIIVSWYITYGVIFLLAAVLQAVVGSAVLFKNSSLSLLLVFFLLFSWSVLSFGYMISSIFSKSRTGTYIGMIGFFAMYLITAAFTDTSTAKSKVIACIFSPAAMTFGIQSLAQSEGNGVGIASGNASEEINNFKFTSALAMLLFDTVLYTLLGLYFERVVPKDYGVTEKWYFLVSPSYWRRKFSKKVPASANDNGVVVEIENDNIEAVGADLQRQERNGEALQIRNLRRVFPVPGGEKVAVKGINLNMYKNQITCLLGHNGAGKTTLISMLTGMIPVTSGDATVNGLSLSEDLGEIRQSLGMCPQHDVLYTELTVQEHLMFYGKIKGYSGDTLKKEVEQKIIEVGLTEKRDVYSNELSGGMKRKLSLAIALLGDSKIVFLDEPTSGMDPYSRRSSWEIIMNNRTNRIVVLTTHFMDEADILGDCIAIMAEGELRCCGSSLFLKNRYGAGYNFSLVKTEHCNTPALIEFVQNHVGEDAKVLSNVGTEISFQLPLDCSHLFAKMFAELDDKLADLGVLSYGISVTTLEEVFIKVAEIGDENQQHTLQKKDPVTKIDASNSGFKLTDNAPLSTMTMFFIHFKALFKKRVRTAKRDKRVVIFGTILPIIFLVLGIALLKGSSLNRNDPFLQLTTSQFPYKSNTPLPYLCESDWMCDSVDQITQAKPQPFTGIGSTVYSTSTPTVFGVEYANLTGSDPKSYSLNAGEEIFKRGFGKDTSPVLGQFGGYVFMGSSKDRTFGYNLAVNTSALHSAIVHKAMLDEALYRSVTSNANLKLTCTDAPLPLTDTTKILFTTIVSFSTSVFVVLAFAYFTASVVPYLVNEKHPSHNSKHQQLVSGVSLPAFWLANFVWDLLLYSVPCIFGLLAIYFFDITPFTGRDCSSCPTTPFAALVVVFVLFGFAIIAFCYILSYLFVDAPSSQTYIIMINVLFGTILMTTSVILDVIDSTKDINTHLKFLWRLSPLFCVGNSLNSLSFATLKLGQGLIDKDTSAFSTDVVGWEIVYLAIEAVVFPLIAVGIDYALSFPKIKAMVTKDPHIVDAPYDVDEDVKAEEQRIASGAADSDAVVMKNLRKVYKGGKVGVVDLSLALPKGECFGYLGINGAGKTTTMKILTGDVLPTSGSATLGGFDIMTQQLEVRRLIGYCPQFDALIDLLTVREHLELFAAIKGVPNEYIDATVKDKMEQMNLNDFEHKLAGTLSGGNKRKLSVAIAMIGSPPIIFLDEPSTGMDPVSRRFMWDVIADISTRSKESTILLTTHSMEECEALCTRVGIMVGGRLRCVGSIQHLKNRFGDGLMLHVRVAPVMNADVDRFVHDTFKEETMLTKERVAEVCATLGKPNRVDRISSHHATGYVLAESLTRNDYIRAHDFCAWWLGEDRFDALSAHLNQGFGDANVLLLERQNDVSRFKLLGTKQTLALSNVFSMIEKSKSDLRVEEYTVSQTTLEQIFNNFAAQQTQETGVARGMEAVLKGEAHDNYQAMRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X9V8</accession>
    <name>A0A6G0X9V8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dynactin subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_006956</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000087">
        <property type="protein sequence ID" value="KAF0736798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X9V8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013270"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03359">
        <property type="entry name" value="LbH_Dynactin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047125">
        <property type="entry name" value="DCTN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46126">
        <property type="entry name" value="DYNACTIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46126:SF1">
        <property type="entry name" value="DYNACTIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21711">
        <property type="entry name" value="DCTN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0736798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="185" mass="20187" checksum="0E051974E1AE785F" modified="2020-08-12" version="1">MDAVVESGVIHFDPDAYICTASGNKICRDSTLCCTKNILLRGKTIINAGTILRGDLAKISLGKFCVIREKCVLKPPPKLLPTGLLFIPQTLGDHVYIGEGSIVEGARIGSCVQIGKNCVIGKRVIIRDCCYIADNTIISPDEIIPPFTYVSGIPATMEKELPEATQDLFTGQIARYFENFRPNKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X9X5</accession>
    <name>A0A6G0X9X5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ran-GTPase activating protein 1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_007026</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000087">
        <property type="protein sequence ID" value="KAF0736871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X9X5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017809"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045203">
        <property type="entry name" value="RanGAP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46761">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46761:SF2">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0736871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="829" mass="88392" checksum="5B4DDDB8BD41EDE2" modified="2020-08-12" version="1">MELILAGDREFVDATRATALLEPFAPSTAFHRISLRNKSYSLDAAQVLAAFLKTIPHGLAVADLADMIAGRPEDEALLVLGHVCDALSSHQFLEIDLSDNALGEKGVRACFGVLERQKNLERLYLCNNGLSAESAQVIADTLLFQGPTAPTKLKTFHFYNNMSGDGGAKALATIFPATPELEDLRFSTTRSQRAGCRVFAEALGVLKNLKRVDLSDNTFGEEGAVVLADSLAKQSHLKVLVLRDASIGDAGLIAISNALVKAGIKSLKALDVSGNDLTEESMSALAALLRTLPHLEELRIEENEIGTGGAVTLAQALHPKSSVPRIRVFQSNSNELTSTGGWHLVSALAAKPDLAELELNGNMFSDDAIAMIEALLFAHAKDGVLREMDDNMEDDEDFDEDIEWEDEDDKQQEDDEVAVEALTKAMEHVSLDVLSFDAKREVVDEVRAKDLLAPFQGRTSFHTISLRGKSYTQAGAKVMADFLGQVQGVKVADLADIIAGRPEDEALIVLTCICEALAGHVLDEIDLSDNALGEKGVRACFAVLIPQPQLKHLHFCNNGISAAASAVIANEVVLQSGVSKSLESFHFFNNMSGHDGCLAIAAMLHGVPNLKSFRYASARAGADASLQLAQSIAKHLTHLTHLDLSDCSFDDQGSVALASAIAKQPHLKVLKLRDASLGASGAKLVVQALVKGGIQLESLDLSGNELEDDGVEGLVGGANALSHQTALKVLRLDENECTSNGVEVLAKAAANSWENLEEVSLYGNEITARGAVAIAKAVASKRFLKLVNLDSNMISSQGVDDLKSVLDAAGKASCLGPLDENDEDAEDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XB11</accession>
    <name>A0A6G0XB11_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_006472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XB11"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010600"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0737301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="284" mass="31489" checksum="7E3DCDD7A74A1231" modified="2020-08-12" version="1">MDQFVTSERIPFSYFPPPKEADDMATTVNAFKPVEAQLVLSLDDLIKERQKAFKQEKSKKKGDAAKTAKKTNDKAKKTQALNKKRGIENNTPAVAPKKKKKAKVAKTTTTTQNGEADGTTKTVRRKRNKKKNNQTAGNAAQTQPNPSKKKQPASNNQQTPKKQNTQPQQPKKQVNKKAVQVNVQRGKAGARALQNTISPSNNKKKQVVVKPANKDERKVLFNVTMKGLKNMTLKQKKRAKKASTGDHPVKRLLGNHLPSGEKKAGALAAKPKMAFKRRNNKKVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XDG7</accession>
    <name>A0A6G0XDG7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_006181</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0738206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XDG7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005403"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF32">
        <property type="entry name" value="AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="69"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0738206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="682" mass="75890" checksum="F0E77E049D2049D6" modified="2020-08-12" version="1">MAILTPRRQSTASIDESTSANASAGAAPQTQPSYIATNVDQIVQVRPAAPTTRSVKDDVPPSMTLIQAFQRTVARYGYQKAMHEKWGDKWYSITWRHYYSRAQDFMKSLVHLGVLQHDVIAIAGYNSIEWNIAYMGTIMAGATATGIYVNSPRDLCHFIASHAEARVIVCDSVAQVEKFLSVKASLPLLKAIVLWHDDVPSTYPSYMPIYGWKAFLEQGANITRGTVLRRMQAILPGQCASIVFTSGTRGLPKGVMVSHDNFCFNAWSFQQTFERDYSTRLSNRDELISYLPLAHVTAQFMDIILPIWCGYEVHFAPRDAMRGTLGKTLKEVRPTRFISIPGIWDKMADKLREVQHTNKGLKKQLVSFATSRAWKKTVQSQFGMSNSKPCGVGIAEKLVLSRVKAALGLDRCKTFSVTAAPIRPETVEYYGGLDMPILEFFGASETGGVATMSVMQCWKMGSVGRALPGTEVRIKKDTRELLVRGRNVMMGYLKDENETKIVLDDEGWLHSGDTAVVDDDGFCSITGSLKEMVTTAGGEVIAPLTLERVLKNAIPILSQAIVMGEQREFLLALFTLRVQFDSDDRPTDDLDPEVVQVLRSIKSKATTVTEARDCPKLLVYLDNKLRDVNKATSKLSFGNFIQKYVILPRDFAVIGGELTPTLKVRRHAVMSKYADLIETTYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XEK7</accession>
    <name>A0A6G0XEK7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_005551</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000071">
        <property type="protein sequence ID" value="KAF0738623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XEK7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021883"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008506">
        <property type="term" value="F:sucrose:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432:SF26">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13347">
        <property type="entry name" value="MFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="338"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="452"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0738623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="481" mass="52441" checksum="3634DE8E656CAA18" modified="2020-08-12" version="1">MASHVQDPAVGITPNDGDYHQKDAEGINDVDKSQQEGMSVPMMFLVCCPKMAMNMAWAAQWAALGPLLQVLLSYSSVQGVQLVGPTAGLLVAPTIGVLSDTTTSKFGRRKPWLFWGAITSIACWAVMMNAQDIGESLGDKGDDRTWTTVFVVICYVWMDITCNLTQVPVVLLIADLAGNRQVTAASIGQVWSIAGSFVVSGYIMFFGPAHQSIKPFMGMLMGIMFVTCMSVCWFVKEEQYIPAVKPDTKKQLKDAFSALWVGFKKLPKVLLIYCLIFLLLQYGYTAYNGAKGQFFGIRVKDGLAENADKCGKEGQPECTQRQKDYNDGVRLAGGVTDTVFNLFGVAYLAIMPFLVRKIGAKWVIVIACIPQALLIIMSFCKVVAIDMILVILTSISQQTIFALQLPMIVYQIGLAPDNDLGMYAGAFNSANCAGQFLNFALATQLVKTSMTFALPVLVGGILSTIALLVAIFFLKLDMKTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XF82</accession>
    <name>A0A6G0XF82_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ae201684_005477</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="VJMJ01000070">
        <property type="protein sequence ID" value="KAF0738868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XF82"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045103">
        <property type="entry name" value="RNF5/RNF185-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12313">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="21"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="73"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF0738868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="210" mass="23520" checksum="3295C961EEF2280C" modified="2020-08-12" version="1">MQHESSTAATAEEDRSHGFDCNICLDHVKEPVVTLCGHLYCWPCLYRWILNHNQCPVCKAGVTQENIIPVYGRGSKSIDPRKQEVPLGDGVPDRPRGQRPEPISRRRHTVGVDGMQEVGFSPMIGFFPSLFGLQFQHATYPLPDTINTSAQADAQQRVQQIFLSSYLLNITFSFNTSLFSTSAKSPASTISLHFCEKDFLLSILGFLWNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XFG2</accession>
    <name>A0A6G0XFG2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_005494</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000070">
        <property type="protein sequence ID" value="KAF0738885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XFG2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003240"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0738885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="32927" checksum="A2E9E11E7516C1A3" modified="2020-08-12" version="1">MQECTTTKTTASLSGDAPLTAVEFKICKRRRDCMINQRRYRERKRGKYIRLEQYVSELVEKTHMMEEHASMLRSSLIMRYEQAGAQRCQSISSYLRLFQHGLFYPHEVEFTTQMDIVRGVMSDSLQFNGEIGGPHSLIRHWEAYRSTFPRLDMHASAIEAHGAEHDIVIAYTTLVLVFTRETLIQLFPHALCREDLIQKLVGPELAFKLRLSFSFDDARVAVMEAEVQMIEGLLDALGSWEDSLFLIEGPTGEGGFLTPNGLIVPKSTTADSTLPATDDVKRRIDFILC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XG43</accession>
    <name>A0A6G0XG43_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_005125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000066">
        <property type="protein sequence ID" value="KAF0739201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XG43"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019865"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0739201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="372" mass="43973" checksum="7BB5245E260C3A4D" modified="2020-08-12" version="1">MADNDKKARRRAYMRNMMKLYREEFKMEMAYLLDRQEQLETQVRQLMLARQQRLPDNDVRCALPWREVSLALQEDAEVETKERESLRHQVSEYRRVIRDLERWVASHWSIKQTPSTTTTTWRNTTLFVNAKTRQLGKRWITEQMYHNAYRAFQLYQFPSMAEVHELHDLDIIPTANGGIDYIHRRQFDINVPASTLLTMYKEIIGRLMSPTSNFHTERTDEITEDGKDQTKLHTLVSSDGEVMHFLTGAFESGDRTIFVGQEILQDELISHPKGVRRSRMLWYEILPLTPTKTRLRCLYVFSQLSNHKGEPYPFEDEAKYWGFDVQSYSPDCQFPHFRQFVRERSAARLAVSQGRVKDYVVAKMTATNDKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XG56</accession>
    <name>A0A6G0XG56_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_005134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000066">
        <property type="protein sequence ID" value="KAF0739212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XG56"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015117"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0739212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="383" mass="44303" checksum="46A7B96B117EC17B" modified="2020-08-12" version="1">MADKPRLHAATKEMEKKLQQRAYIREFMRAYRGREKREMEGLRRQVKQLEADLARLVESSQRQGSTSTDTQTTDKTVSASALSWKDVSLALRERKAAGESMHAQLIAKTNEYTDLVRNMQCWVASFSSIPHVLNASCPTWRNVTLFSNPTSRTMGKSWITKHIYHNAAATFHRHRFPSMSSPDDFHEFYIDFAESGTFDYVHCRQFEEATPYEVVCNLYQHHICSMMLADGFGPVETQIDKEADETTIVHRMKTPLAEQINLLCGVFPEGDDRCIIVAQQIHDDESFKHNHGQRNRLWMAEIHRLPIGRTKRRILHRVSQAFTATSMATMEEEATAWGCNLSLYPEDLREAKYTEFCLGLARMMHVNAARRLRDVRERLEIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XGI5</accession>
    <name>A0A6G0XGI5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_005145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000066">
        <property type="protein sequence ID" value="KAF0739224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XGI5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008979"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0739224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="384" mass="44417" checksum="FBC34F96BD3F7A05" modified="2020-08-12" version="1">MQKDSSDGRAGGTKKKRRKGQAQRMANYRMEKKKELEMLQLTIGKLEQIKRQMTTTCGSDARTHILPWREVATALMESLRDSHTSHDELFTAVQKTHDLIRDMKLWVAANTPIEASPNPRQRSWRNFSLMANPESRRQGKEWIVQQMYYNADYMFEQYKFPSMDSEEVIDLDLQISANADFGYMGVFRSLEVMSISLEDFVSIVKNTIFSIQFFVLDYTPDMPLAIHEVDGRTIQLAIATPRKEFVNILFGEFHTEDRTVVVMQQIQHDETCQPVNHRQRNRMSWYDVRRLPGNRIKRRLLVLDLPVESEDFPVDLDQDARDHGLTLSGVPDHLKESRLARQMKLNALNRIEQSISLLGGLVQSQVKGELNTDAPWRAATVESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XGM2</accession>
    <name>A0A6G0XGM2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_005136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000066">
        <property type="protein sequence ID" value="KAF0739215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XGM2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003095"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0739215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="245" mass="28482" checksum="B4B635E211293CCF" modified="2020-08-12" version="1">MMDGSTGAVAEVDMALLEKADLKLKKREYMRNMMAFYRQERREETETLKTESKRSLLLPWKEVAVALKEERDDAEATNETLRRNARELKSLVSTMKQWVNVNVTRSCLQSGMTTTWRHVSLCAEPQARSLGKEWITHSSPLHGLNALPTRLDVRPMPDGRTKVRVLYRFAQYFTKDGYVSLDEEAETWGCDLSGVPEEKKEDTFRQYATYMLVQINSNHQRRINSHLTLMMLEERHAHAEKIEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XGQ3</accession>
    <name>A0A6G0XGQ3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_005164</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000066">
        <property type="protein sequence ID" value="KAF0739245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XGQ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010075"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0739245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="243" mass="28081" checksum="05B80232061BB7B3" modified="2020-08-12" version="1">MAAIADVQPIHYHVTLVSRGDARLHAKQWLVEQLYYNTERVFHTFPDVDAADNFVNCSAKCAGPWLHMVEMCQASWPNSLDEIKRLFLDPASQKIICIDEKLEMERDGNTRLAHSPADEQFPWYILQGHFYDADRFVAVFRHLNDDEASDNPASHPDYYEMKWVVVHRISESKCVVRMLGYRTMLLDGMIAFAKNFGNNRLDQTGVDVKTVEREVAAFGNGFVWEYQKRMQALIGQLEMLSME</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XHV2</accession>
    <name>A0A6G0XHV2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Splicing factor subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_004619</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the SF3B5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000060">
        <property type="protein sequence ID" value="KAF0739845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XHV2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010298"/>
    <dbReference type="OrthoDB" id="274726at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009846">
        <property type="entry name" value="SF3b5/RDS3-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017089">
        <property type="entry name" value="Splicing_factor_3B_subunit_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20978">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20978:SF0">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07189">
        <property type="entry name" value="SF3b10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037010">
        <property type="entry name" value="Splicing_factor_3B_subunit_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0739845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="86" mass="9813" checksum="D1B910936A26F1F3" modified="2020-08-12" version="1">MAADRFNINRQWEHLQSKYVGTGHADTSKFEWAVNQHRDTLASHIGHSDMLAYFAVAENESIGRVRFNMLEKMLQPCGPPPKKQDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJ87</accession>
    <name>A0A6G0XJ87_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_004110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000052">
        <property type="protein sequence ID" value="KAF0740373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJ87"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019447"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0740373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="267" mass="29214" checksum="86D77AF8F10F8EC0" modified="2020-08-12" version="1">MGFSLAGLFALEFDYGRAPSAGIQQLRGGVAATKQRGSNRCRHVDGFPTDLWPSFLHIFSWTCWIEFVGHDRRRRVVDECRGDCSHLERACTHPTHAVFRIFDFPLETTMANLPMFTLIGRVVVLVSTIISFFCCTAVTGVSAGDYAFLVSFIALAYTLLHAYFVTFKRNVTFTFRAQLVIDAVLAILLLAGAIAVVSSPWAKWYGLPGAGTAAVVFIFFATAAQIAVIVMHVMSTSRSDEPTLETPPNVYVPSSVPAGKHGVELQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJR1</accession>
    <name>A0A6G0XJR1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helicase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_004108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000052">
        <property type="protein sequence ID" value="KAF0740371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJR1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019449"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005114">
        <property type="entry name" value="Helicase_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37066">
        <property type="entry name" value="HELICASE-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37066:SF1">
        <property type="entry name" value="LNS2_PITP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03457">
        <property type="entry name" value="HA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase-associated" evidence="1">
        <location>
            <begin position="140"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="1">
        <location>
            <begin position="214"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0740371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="306" mass="34998" checksum="A4DF3AC2D71D00E5" modified="2020-08-12" version="1">MADKMNLGFLLNPEDNNAPYATAEAAEYKSPLASRKRRRCCSPTIKPTKKQGKRKPNVFSVDTQTRFVDLVRWMPPGKLVGKTFITHDKAAPPSVQGYEFNLKRFRNARHKKQLDPTIESELTKLGFVWNVTDFQGTLTIEALECFKAIKGHVNVQQKFVVPADDPRWPKSIWRLKLGHRVHNYRIKRKSSMPAWQREKLDALGFKWDGIKQHIAFEKKLDALQAYYNAYGHLRVPQSYKIPSANVKWDGEPMPLGRVVNKLRQGKDKMALEKRRLLTKMGFVWSNAGGGGGTTAQDDKTIDISYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XMM7</accession>
    <name>A0A6G0XMM7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Anamorsin homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Fe-S cluster assembly protein DRE2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_003309</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the cytosolic Fe-S scaffold complex. Electrons are transferred from NADPH via a FAD- and FMN-containing diflavin oxidoreductase. Together with the diflavin oxidoreductase, also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.</text>
    </comment>
    <comment type="domain">
        <text evidence="9">The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.</text>
    </comment>
    <comment type="domain">
        <text evidence="9">The twin Cx2C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the anamorsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000036">
        <property type="protein sequence ID" value="KAF0741633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XMM7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011103"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03115">
        <property type="entry name" value="Anamorsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007785">
        <property type="entry name" value="Anamorsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046408">
        <property type="entry name" value="CIAPIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273:SF14">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05093">
        <property type="entry name" value="CIAPIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anamorsin C-terminal" evidence="10">
        <location>
            <begin position="192"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Fe-S binding site A" evidence="9">
        <location>
            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Fe-S binding site B" evidence="9">
        <location>
            <begin position="199"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cx2C motif 1" evidence="9">
        <location>
            <begin position="199"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cx2C motif 2" evidence="9">
        <location>
            <begin position="210"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0741633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="238" mass="26081" checksum="C48EAD36DEF10541" modified="2020-08-12" version="1">MLVISEAPYRTAADEFASSQAQNVSVIDIQEAEKKDDGSAGAKVVFFGGLAHFATLHRVLQPGGSLEGYIYAQGEDNKNAALMQLLLQGFLNSNVELQGDRLHLRAEKSGFTNGASATVSFQRVLKPKWTVVADDEDDIMDEDDLLDDTDDVLKKSRDDCGVSKDGKKRRCKDCTCGRKDEDEQPFVTEDELKEMVSNCGNCYKGDAFRCGSCPYLGQPAFKPGMGKVVLNLDNSDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XP55</accession>
    <name>A0A6G0XP55_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_002970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000032">
        <property type="protein sequence ID" value="KAF0742035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XP55"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0742035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="101" mass="11332" checksum="6E5BA45FC2D7D8A3" modified="2020-08-12" version="1">MELLEKHEEFTATSSRSSGIAEDEPETVMLLDELSALFQAHKKSQDTEKAAAAENLARQQDLKLIRETAMETMGKRKHESSGSSDETSTSSKKKEITHFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XPT8</accession>
    <name>A0A6G0XPT8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AraC effector-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_002691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000029">
        <property type="protein sequence ID" value="KAF0742288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XPT8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009414"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="entry name" value="Regulatory factor, effector binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010499">
        <property type="entry name" value="AraC_E-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029442">
        <property type="entry name" value="GyrI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053182">
        <property type="entry name" value="YobU-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36444">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR PROTEIN YOBU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36444:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR PROTEIN YOBU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06445">
        <property type="entry name" value="GyrI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00871">
        <property type="entry name" value="AraC_E_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="Probable bacterial effector-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AraC effector-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0742288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="138" mass="15306" checksum="323B184850CC498A" modified="2020-08-12" version="1">MAPRIEHAKELFVAGLQVHVPPGPCPAIEELWARMSPHLQGKSSYGVCYDFADGMYTYLVAIDVEKGQPIPDGWTSMEIPAHDFAVYEHAGHISKIAETWLTIKNDDTVTRDFSVPSIEKYPAGYSSDTSLTIWIPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XQ57</accession>
    <name>A0A6G0XQ57_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">Ae201684_002368</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000025">
        <property type="protein sequence ID" value="KAF0742666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XQ57"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018422"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0229">DNA integration</keyword>
    <keyword evidence="15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="13" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="14" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="18">
        <location>
            <begin position="275"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF0742666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="880" mass="97933" checksum="7CFD1B15EDBA0415" modified="2020-08-12" version="1">MEKCFLKKKHNAEVEQAKSRAKVPEANMGHGGDADVHPSSENGPRQAIDHWNWCGAAALEPKVANQVEQGQVDRKLAETEWIVDTGATHHMCFVKGMFNDLHPVDSSMANSVGLPDGGKITVEGIGTVKLRVKCSATGNQATIQLNQVLYIPRFNRNLLSVPKAYAAGLRFNLDAKTGQVVLSYGDQSIVSADTGGTPLYILRHIPPSPQPVQAEANALMAQPTFDLWHSRLGHLNAHDMKRLLDKDIVRGFKVTRSDLNCWICDACELGKKSKRVKLPSATTPADKSNAKVHSDLTGPIETPAIDGARYVCLFKNEFNDLLVQHRALVENKHNLPLVELHSDNGGEFLNNQLKDYCTNEGITHSMSVPYTSQQNGKVEVRFRDIFAKARSMLIDANLPKQLWDYAVDCAFYCLNRCLSGGRKQTAYELWNGHPPNLNAMRVFGSLCYVHIPNKVDVPTESGRAKAKRQKLDYKAIRGIFLGYAEDRHAYKVMDCTTGKLGVSIHVTFDELDSVASQKLKRNELRKLGQIYELTFDYYSRQASQDIDFLFNGDTTMTALNEEEINALKSFVQYFNLGDDDSGETNLVEAYSGCFQVSGLTFKATDSNLVNVSKLEAKSEELVGAEVELARAACYNVALPAASVPIPRSFQEAKASDEKDHWEAAIRKELDSFKANGTWKYVQAPEDRKPLKTTWVFRVKEKSDGIIERFKARLVVKGFLQIKGLDYSEVFAPVMRLESLRTLLVVANSHDLSVDQMDIDTAFLNGILEDMIYIDLPEGLSVEDILDEIDWVGANPTAADVKRVACLSVKALYGLKQSPREWHKVLTAFLGEIGFEKTNVESCIYTRQTNGQQAIIAIYVDDLVLVAQNDNVMADLKSAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XQA4</accession>
    <name>A0A6G0XQA4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Retroviral polymerase SH3-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_002395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000025">
        <property type="protein sequence ID" value="KAF0742694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XQA4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004392"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retroviral polymerase SH3-like" evidence="1">
        <location>
            <begin position="7"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0742694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="166" mass="18668" checksum="5DF792A34DCD0D86" modified="2020-08-12" version="1">MRVFDSLCIAHIPSKAQIPGGNTKRQKLDNKAVRGIFLGYAEDRHVYKVLDCTTRQPLVSIHATFDELDSIASQEPKRKELLKLAQIHDLTLDFYSRQASQEVDSLFNGVTTKNTFDDKEISALDSFVQQFSILDNDLGRNQSGCIKWQSPCMSQPGLQPVQLQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XRS2</accession>
    <name>A0A6G0XRS2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_001957</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000019">
        <property type="protein sequence ID" value="KAF0743268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XRS2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019778"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0743268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="37745" checksum="DB193073C696FDDF" modified="2020-08-12" version="1">MSTGYKGFRSWAAQECPTLKPGETYDTRATKFSQMGSSIVSPPTSIRVVNPSFEALTRNHYGQVTPQDFSNPVRAAKDNGEIAHSRTFLGQSLYQRDFANFHEEGKRIAELSMEAFQAAFDSLAEEPNQESPDAVKKINRDDVGELLQAVYGKPPATRILEIYAHMFDVCPDGFVTWEVFQEATLRLSSFLLHQTIKPSSHSIGWVDFVKKVLPNGTPSSSHQIDYGTYGSDPLARPYMNRSHGMASTTSDLFDGSTKASYHIPRYQGFIPHTKCNPTAVSQGECEKPRPKAEDLRLYHSNNIPGYTGHKPVDSKNVRGEAKTGCDVRTTNGLVYKPHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XRS7</accession>
    <name>A0A6G0XRS7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_002211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000022">
        <property type="protein sequence ID" value="KAF0743157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XRS7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015855"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0743157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="232" mass="26166" checksum="EAB422A1BDB81936" modified="2020-08-12" version="1">MASVFVDAATVVCLRESATGRSWEVLLGQNEVKNWLRSTRDATVIMRYPGEWKFPGGSRDDTDTSLEATAIRELNEEFVGINAPPQSMVLHWVSTKETLAVKGKRFKMHNFVALANENAWLQDVHLVDRVNTRLAEKRAAFERSVADGSFWSLDAEAKEAISPEVHAVQWFPIHEAIAMMTPGRLAHVNAFQEREFAQYGVASRDPMFQSMKTLEHVAALSRQEIQQVHSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XS18</accession>
    <name>A0A6G0XS18_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_001845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000017">
        <property type="protein sequence ID" value="KAF0743370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XS18"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000696"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052394">
        <property type="entry name" value="LRR-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0743370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="954" mass="106964" checksum="CE78B9F7830321C1" modified="2020-08-12" version="1">MLQPTRPMLTPGTPGDRRNRGGNAKSMSVVETPEELFPLRKGDVGRNRHATIMPMAKPSNDRTFLTRLKDDRGELRPPSPFEPGGGPAEDTDSGPEPENYFGGEALARFWNMFQKQDSNLRSKRPRPHSPRTTYLSRLRQLARCPEPLGVIRKCASPRVDLHDYEIGNDLASAMGASISLIPGIDAVNLASNRISDRAAGDVISHLQVASALGGLDFSNNKLNLHAAKSLSNLIAITKTLVDVNLEHNRLGSGAVVVLCDALKKNQTVTRLNLSENQFSTAGMNAIASLLVENAKIEELYLSWNKIRGVGGQRIVEAISYHNSLRVLDLSWNRLNSCPNHSIATALASSLTNNKVLAHLDLSNNALDAKACAILTSALLTNHTILGLHMTGNQAKVDARGFLLPLTTPIELHTQHKFCSIKHFEIHQENSDVTPSSAPSAFDAYWPYVDRACWLCGRWSEHRFVWTPSSQKIDAKAKVKLHLSIDDWTGHDMTRTHEAFMLYRMLPPGKTKYFITVETEAQKPDEKPKRQYVVLKDKRTARILRTHGDEQTFGTLQYVNYIAMTRYDGPNPCHATMPRPGANTVKVLKWDIKKSVFATRFKESPSKAPVDTDALVAKAFAVDFRHCKIDRIVRDPDRKKELEAAGVGHYRAITNLYRKYCSRGARVAIDQLSISWSGFNEFLSDCHLVDESSERCKASDMDNVFVAANLEMTEEAKQQDNPDRSLTRFEFLECIIRIAINKYCNSKPVVCETPAQALNRLMEDHLVAAVPEDPNEFRTNYLYKEEISDIFLEYVVLLQDLYAANSGQYCRVGEPKRMAIQELVQLLESFRFFTDTELKPRDLREPFFSSKMLLLDEMAPPESLKKLLCFSDFLEVLLRVALLRYPPPSTDLADAAASLQKLFAQHICAKDKLVETFQHGADKVRIVGALSRRPSKRTAVNSLPRKPSVDDGNNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XSD7</accession>
    <name>A0A6G0XSD7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_001929</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000018">
        <property type="protein sequence ID" value="KAF0743303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XSD7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007955"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43102:SF2">
        <property type="entry name" value="GAF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43102">
        <property type="entry name" value="SLR1143 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="5">
        <location>
            <begin position="29"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0743303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="304" mass="33964" checksum="5181C22DD74D6CBA" modified="2020-08-12" version="1">MRLTELCNEEDLTGVDILEGISLESWKPDRHSDRCNACVKKFRPWYRRKHHCRVCGEIYCSKCLQYRYVRVPWIGVALTMACTWCCDTSSVVVVEPKTPENQLPKTSLPSMMPVTAAHKRLHKPDPMLLPPRTMPTHGVVTVQFKNTTSIKPLVSPILTARSTHERLNHLCASLCDAMDCGYGAIVLSTPPSIAVVAHKGLTAVMHTDSFRLICTRAMKLGRICCVNQDDQLFQFCGTAPLVAKKDDAIGCLLVLDTAQKTMENPSHVLEHYARIVLDILALSGRIKTTTNVQHKLISIRSSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XSP4</accession>
    <name>A0A6G0XSP4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_001856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000017">
        <property type="protein sequence ID" value="KAF0743382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XSP4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000707"/>
    <dbReference type="OrthoDB" id="2139939at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044688">
        <property type="entry name" value="SCI-1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34117">
        <property type="entry name" value="STYLE CELL-CYCLE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34117:SF1">
        <property type="entry name" value="STYLE CELL-CYCLE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0743382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="298" mass="34794" checksum="B3A3953473EC6FE7" modified="2020-08-12" version="1">MSKRKSRDSSEERHDKKKKSHKKHKKHKSKHHHGDAPEISQDDYFEKAQEFRVWLKLEKNIYFDDLSSTDAQSYFAKFVHKWNGQRLDSMYYTTIPQSILESIHRTKHKWGFKLNENERLELATTKDSVDVSTNKVKHASNPVDDRKKEPARTSSKHKSSKEEDADRDSDEERKRARRDRKNYNKHKEMVMEELVPKASGRDATIEKKRQVAAAVHGAARERDDAKDGLNLSDDFLMGGSDDFQARLQRRKQAQDRKHEEMQQRVAAAQDAEAARMQKFLADMGIQPGQDRITIAPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XT38</accession>
    <name>A0A6G0XT38_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_001447</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XT38"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002686"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031543">
        <property type="term" value="F:peptidyl-proline dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071456">
        <property type="term" value="P:cellular response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051559">
        <property type="entry name" value="HIF_prolyl_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12907">
        <property type="entry name" value="EGL NINE HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12907:SF26">
        <property type="entry name" value="HIF PROLYL HYDROXYLASE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="7">
        <location>
            <begin position="132"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0743797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="270" mass="30598" checksum="8ACCC6377C205D1A" modified="2020-08-12" version="1">MLRTSRWTIARFLRSKGFSTPRAFSSSNLVEEYGLLPLFPPATCEALRRDLEEDGFCILNNFASKDVAQAMRNEAQRLFDEGYMFQSMSVDEHGRSFPKDNVFASELDGNEWDVAPTILHYTRSVMLQAPEMLNSMFPELQISSRAYATKLAVSLGDGASYPKHCDTAGLPDQRKVTMVYYLNPNWEPSHGGQLQVYAKDGVHVVEPRSDTLAVFWSDQVVHDVKPCENSPSDVAAQRFALTLWLVTDDPKQIIDPNHPLYDLRCQHFQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XTB7</accession>
    <name>A0A6G0XTB7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_001520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XTB7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018320"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF214">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="201"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0743877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="477" mass="52334" checksum="67DA6D9D870E0509" modified="2020-08-12" version="1">MADSTQSTAPSPTTSHHAVPQTTKATTQSNTSSDGLTPSPIFQNAPTTTPSQHRATSSSVTILIVVAAAALLVVIGIIFYCRRRMKSTKRRPNNGSRTSEDPVMPLFTLTRATSQSKLDSESSFVFLDAGRADIVLHDHAVKCDQVDTEQPVATGFMNMKSVRGEPLDKQLSYIEQSSSSDSKAPQRVVIHTLPILDRSSVVVLSCLATGGSMWTCKYEGRPAVVKRVQPAEMTTAEMDTFIADVNLIAQLVHPHIVKLHGIVHMADDVCVVAEYMERGSLGVVLHQKSLALSWAHQLRLCWQVASALSFVHSQSHYLRVKPWTTRSVLVDALLSAKLNVFDHMTNFRRDGKHEVALHLSFGKQVMAYEAPEVIFHDCARSSSGDIYSLGVILAEIATRRLPYQSWVEQGGYIGCDVRISDNNPANLPHEGSAAFKATPVEFQRLVTACLNRDVLKRPLALNVADDLQRLLDEAENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XTN3</accession>
    <name>A0A6G0XTN3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_001417</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XTN3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013062"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04371">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF289">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE VIK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="305"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="DEP" evidence="7">
        <location>
            <begin position="606"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0743763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="765" mass="86507" checksum="FD0424352980B3E4" modified="2020-08-12" version="1">MATIANLTTTVPPVNNAAPSPGFDNTSYQWLQILYCITYGAMCMLSLALIVYLRHHRSTAYRGDTSAALKIVLPAFESLFWLTAIVTGVYTLFFILSSIFVWAPFDKKWFSELLPQGRQFIYFLITILFLQRSLTRHALVRTFIFALLLAVFPVVLTVLMDETEWSEYAKFTILNIVRAVYVAWYAWLFIRPVSRASPRTQREFYAYVIIYFATVYAYRTLFFYYDGDLGTAFVFVSAIYGSIAPLFIWRLLRADTEHWRGFSDRAIEIQQHFREAQGMQEIVSSQGLHVLLEMHRKDLIDFAHLQFDKQIGIGASAHVFRGHLHSSTQVAIKAYSPTEISQATIANFSKEAALCAVLKHPNIVLFYGMCICPPSICLVYELCRGSLDEALTNFRADYTEPSWPKLCYMLDAARAVAYLHSFTPPFIHRDIKPGNFLLDATNRVKLTDFGESRSMAGKMVEIEAKERTMTVLGTPDYMAPEVIDGKAGMAVYTETADIYSLAITLWDILHPSGDKYPTSNRNHLSVFRMVLDGQRPPIDPEVPQTLHDLLENAWNADPIFRPSAKMVVAVLEDLHEDLCGQITYSLSGSMAYLADHKKQAKNVRYFSGEDLVRCLIEHKYAFEVEEAIRLGNALMDAGCLHHTKHNLPFEGSATSTYTFDMHQLDMNKPIADSKVLNTNAELIDDSTAYAGTSLLGDNVGLCGCRKLGQGHVKPKLPRKKLFQRRKDDHHMLTVNLLQQNNEFGEFGTASTITSTPIMLTLDDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XTW3</accession>
    <name>A0A6G0XTW3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_001687</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0744054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017510"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002733">
        <property type="entry name" value="AMMECR1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF91">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE PRP16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51112">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMMECR1" evidence="6">
        <location>
            <begin position="87"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="947"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="1139"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="814"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0744054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1576" mass="178454" checksum="87C2F0C3855CADDC" modified="2020-08-12" version="1">MLPTPRMRRQVQRRREIKITESHLEEFQRLMAPQIDCRAHFKSQKVHSTPYWRDNNLHFPQNKPHWCFASRTWSQNYFAKRLWPKAQFFEVKFKGKIRDPDHNSAFRRFLTNLSKEKIPGLKFPLTFATFMPSHLGDTRGCIITSTYDGRNLHKASNLNRFEPAKQAKYSKLLFTVYGKPMLQLANVTVHVDHDIIRGDYNFTDGCGSISPDLMAELVLGYKGQTDSEICAIQCRLPGIKGMLVVDVRAPARTIRLRESMVKLKVLEVLEHKANFDGSRTYSLLPVVVLKCNQVSDCAFLNTQIISLFMSLGVPFAKFHTRIRTYVESIMYMGLDCRYALQFFHLRGLDEAQLRSKLQAKRLQLASVHDEILDRQANAQASLRKKANKERLRIPITKARLLLGVCDYTNSIYNGECFLQITTPDNPKPQAIVGKVAVTRNPCYHPGDVRILYAIGACPALQHLTNVIVFSTQGHRPAPDEMAGGDLDGDSFFVIWDQELLPPAAISATAFDYRPSAVRQHIRRWATRVSAPILPTTRQNPLRGMARVTDYILRGGSTQTISLVDNLMQQLQGLPPSSERRELNEVLNALFVCGVDQLDINIDMVLSAINMRIRHAVKAAGIDGTPDEINKLAALVHPCLDMRKTPTALSASVFASSVDKIETPVSPEDFLDLQKLFMWAVLDVLTNLEKKVLRDASIPDSLAITFEPTVVKRVVQEVDMLQKEIRKQHDAFCNRKEAQIFSKIKLLQNGLDEINLKTANVARLVQTAKEEVDVLKASLDKEELHAAKLLEAYKAPARYFFMSYLLTEADRQADAKNKQRQHDEYIDQCAKVKELKQTFQSKRLELLNLQMQANIETMAALLAVQRLNAQKFLVTPDIADAFMQGTKSLETLIERRDQFVSLCTAFASAGAGLPMDEARVALLNECLIAEINMFTKDLPVYKQRNELVETLEKHSMTLITSETGSGKSTCVPQFYLTHRILDESTSAAQRFCLVLPRRAATKNLARHLAETRGTDVGQTIGYHVGTNAGRSDRQVHASRTLLECVSGGVILGKSISDPWFAQFSVIFVDEVHEESPDLYLLLGKLKAARKHHSKLKIVLMSAKVDELRLISFYGSMAVEKLPGRQFPVTSEYCGSDSGDYVAQALRQGDDVLVFMPRISDIEDAIGRIYIIEDMPMNSVKAWPLHSRVDNKIKDSVLSGKDCGKIRNVIFATNIAEASLTIPNLGYVVDTGLEVVVTRDVMSGAIVHKINSIAQTSVIQRKGRAGRLGPGKCFHLYSEADHLNFAQTKTANYNDLEFNTLRLIASETNPFSFDWIQHPGTRELNFCVDLLRKFKMIEMGTDNEWHITSKGLDASKLLRLGIDINCVELLLFSRENETLLTKAAIVIGCMEYAHLFRRCEFKTGLDIDWDATSVCDNFVNLFYEYQRQTKKKEWAVLLSLPLHAFESIDRLRKKILHEVQLLDPIGECENGTVKTWNECVAAAYPNGHLRILRFNNIGPELYFVDNPSTTIRILKDEMARQRLEWSMEKTYVAMLISCHRNNPSWLFGSFVEEIYDTNSGGPPENPYESLYYTSTRLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XTW9</accession>
    <name>A0A6G0XTW9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_001465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XTW9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002703"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0743819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="378" mass="42606" checksum="34EA420039AA0C48" modified="2020-08-12" version="1">MIHFVAALRSLDSWKKEEEAMAVQVADLEHFSSPCVKSPMAKSSDIKLLLEFMATSTVQINFLIQLPSIELCLAQWWPLVSQGESHVTPSMLSHLYLGLGTILMEGRTANLTQNAVKMLMRGRWCKWEKWDPDADPPLNQADVHRLVFDLGYLSVQSDKLHDYVSFFQSMQFKLNAFFVNFGASAKASLTERRSTRLQRLETKESRKSKTIVLHPMAQASDDDSAPPDDPTVDFMTGGVKSNIEAKLTPMTITLFPHIRTHEPSSQIVVKDLRLLLPEFQKKFRPMDAMAAEMPVANATPLRIRSIPWMNASNQLASARTSDKTAKALANPLKTLDDVERLVDECAKSLRSPADDDDQVMLRRSISHPVLRHRLHLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XWM6</accession>
    <name>A0A6G0XWM6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_000691</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000003">
        <property type="protein sequence ID" value="KAF0745121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XWM6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008832"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006564">
        <property type="entry name" value="Znf_PMZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31973:SF195">
        <property type="entry name" value="MUDR FAMILY TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31973">
        <property type="entry name" value="POLYPROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00575">
        <property type="entry name" value="ZnF_PMZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="6">
        <location>
            <begin position="598"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="692"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="702"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0745121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="715" mass="81203" checksum="68B7A1D2A7D4B7F4" modified="2020-08-12" version="1">MELDDPVESHDHEDVGNFATRDGDTKAGIGHAPPRRPPVPLIEMLHRAVALRLLHANSVDDYVARSQAADIPLPMIPPVQTNDTVGKINDDETFTPLIRLNTNQNRAVFGDFKQLASALKRLAIQSGFEVRVKYSSKRNKRWECRHRDCPFLLSGYRNKENKVHVTDIELMHNHSLVPLFSSDPHLETTGTGEDPATTDQKPSDKITRNTTLSIELVLSSIFESETGQDVMAKDPEEMRLKYIQTMLFQQYGATISSSMASRAKKKLVEMFYEPSNASYQILRPYFEKCVTANPASFYVIDHVPNITPNAPHEYGRCLLGVGPAFRLLSDSAPVIVLEAAQMNTEMHKVGHLLVATTRDYNNDPIFLAMAHVPVSDEINWAWFLQHLKENQIPITKHTTFVTDGSAAVSQALLQVYPYQPHRYGIYQFLQMVCHMSGQARLTPEEEHLILQMSNSLNMDRYMESFSLLWATNKDLCRCIEGFPKEQWVLAAMIERGWPTLRDISLRHCVGEFTKSSLGSLLTSCNLVPCFYLFLLSIYKSTTVRFNQVSLLSDMVLLPYQQNLLNQRLSESSRFEIIECRPQEVYFAHLQNAMNNHMYKIVNLRSNSCTCGDWQQFHIPCAHGLAVFSAIGRNIWECIHEQYFARKHKMLYSHARSAPVVPVSPIDLTPDLTMEAPAMILEYIRNMAQPAQTIEGATPRNKPGPRPKKRKDVTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XX59</accession>
    <name>A0A6G0XX59_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_000651</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000003">
        <property type="protein sequence ID" value="KAF0745077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XX59"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003127"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0745077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="29983" checksum="1DE20CD7F43F565E" modified="2020-08-12" version="1">MGQGARGSKASDHRAAASSLLQDIFHGDVTERIVAFLPLQDVLRLEVTAARIVTKDVWTFLITTFEASIEGISNADNPTMPREDEDVDPKANYLNLVLNQKTSTGGNDMSICHFAPNGPYWHLIEDGDFGSCMHLQSVCWGDWSAFRELPPSVYDVVVRMKWDSQDFDRVDPMHFDCTVEMEGPQEPLLSIDLSADTKEDFRRNVGRWINLNLGSIILSSRSRVNMHYRGVYDGWYSNWTVDWIGFFPSNIVPLGVSVARRHAHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XXM1</accession>
    <name>A0A6G0XXM1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial import inner membrane translocase subunit Tim21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_000372</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
            <topology evidence="8">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TIM21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XXM1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005266"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.320">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit Tim21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013261">
        <property type="entry name" value="Tim21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038552">
        <property type="entry name" value="Tim21_IMS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032:SF6">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08294">
        <property type="entry name" value="TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="197"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0745346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="224" mass="25070" checksum="69195AD8FD040AAA" modified="2020-08-12" version="1">MLPARRFARLATTRAAFVKNIPARKDPRSAVLSRRMFSDNAKPNPAGPGEAQTDALVLTPYQKVAAGTKVGAWAAIAGLTCVCGYFIVRELFPSRMSPNSLFSEASDICLQNDLIVQRLGQPIRCYGRDNKSSSKEGRRNFIEHVELKDKEGNKTRLRIKFNMKGPNGTAEVWAEVNQSMPAGEFVYLIVRTFTGEIIKIQDQRQILQAESEEEREALRRLLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XXX6</accession>
    <name>A0A6G0XXX6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_000353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XXX6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006859"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35213">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0745325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="306" mass="34909" checksum="F99601955BB13CCB" modified="2020-08-12" version="1">MTDAKDIHQDKPRWGKWTKEEEAYTARLIADFTAGLLTDVENGTTMRAWLSTKLHCCPMRISKKFVGEHSIGKRMFERNETRLAEMTDDIRRQRDMDLDKLYADFYDSWMREERERLELKSQGTRKRKRNRTPKREQNALVLAKRPNSPPSVAVKPSAVSTQVLATAKNASPAQQKTLPRLPSDTRVEPKGSMPAKALDQAPRRQMTGEKPSINLQLSSPPCPLKAKTNAPPPSKTETDILDLALDMPSLDFDDSWLTDPFDTSCIRVDDVDPIEPLDRSDRFDLDLMLSPTSVMDLYDPFFDAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XXY1</accession>
    <name>A0A6G0XXY1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CBM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_000389</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XXY1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011969"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46155">
        <property type="entry name" value="BIFUNCTIONAL INHIBITOR/LIPID-TRANSFER PROTEIN/SEED STORAGE 2S ALBUMIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46155:SF1">
        <property type="entry name" value="BIFUNCTIONAL INHIBITOR_LIPID-TRANSFER PROTEIN_SEED STORAGE 2S ALBUMIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026284684" description="CBM1 domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0745368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="565" mass="57464" checksum="89907CFED5B9CFBE" modified="2020-08-12" version="1">MKRAAFIAAVLAVATATPVSVCRDATYSIDGPICSGSGVLPAGSQCPQAGSVAMQDCHPYLPSWNAATSSCVLKERATCVKIATGAWGCVLPSVGCGGVAPAKKKNQVPFVCDPNESSSSSDELWSYSETDAPSVASTTLDEADLSWFESSKTTVQYEVGCANKAAFQPVTRPPPTTSRLRTEQPTPAPTPLPTQAPTQPPTSAPTPLSTPAPTPIPTSTSTPGPTSAPTPPPDTDFNTNCHSFTNTSLDAINNSKINSSSNSCANPGTNPRPNSSSDTRPYPTPTPDSTPGPTPAPTLEPTPAPTPSPTPEPTPAPTPEPTPAPTPEPTPCPTPEPTPAPTPAPTPAPTPEPSPAPTPCPTPEPTPAPTPAPTPAPTPAPTPEPTPSPTPAPTPCPTPVSTPTPAPTPAPTPAPTPAPTPVQTPCPTPAQTPARTPSPTPAPTPVHTPYPTPRHTPVSTPSPTPRPTPAQTPAHTPFPTPAPTPRQTPARTPEPTPRQTPAQTPAPTPCPTPAQTPPRTPSPTPAPTPRQTPAQTPAPTPCPIPAQTPPRTPSPTPPSTPVIYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XY49</accession>
    <name>A0A6G0XY49_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Palmitoyltransferase</fullName>
            <ecNumber evidence="8">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_000506</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="8"/>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XY49"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015063"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF85">
        <property type="entry name" value="PALMITOYLTRANSFERASE HIP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="477"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="521"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="107"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="209"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="9">
        <location>
            <begin position="431"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0745492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="622" mass="69426" checksum="5C31CF184917A40C" modified="2020-08-12" version="1">MSAACLKYDGLDASDDESKTDTAFPTMNRINSSLVPPTIYECAQLGLLDELQRLLLQRSKTSEWSVNTPDNQNATLLHWASFYNQLHVIKYLLALPHINVNAVGGDLLSTPLYWAAHRNNIQAVALLLDHHADPTIADKHGFDAYFVAVQSGYTILSAFFIAKGCNIDTPSQDADRLTPLMWLCRYKFELDTARMLFGLGANVHETDAHGNTALHLAATSDFVVAAKYLLDRGVDIHAKNKRGQTALDIANDVASDIETRTSGKRTAATVGLLRSVYRYDESYNTLPVSVLKRHAGLTAFWTPWFVMGLIGVAAHKLDGRDVVVGIAASVAFGYWLVKVAGLDVNPSKLKYSRLMFGVNVHSIFWITFGVALLVAEGALYVHATMVFFVFFTGTCVCVYWTTTTSPGLLSTTIQERHRNVMDLVAMHSRPEVKFCSTCLQHRPLRSKHNVELNACVARFDHFCTFVANVVGANNHTFYFGFLFNSVMGIGVYLAMIVDYLAREGVLNEPTYWRTLARVGHNYPVVLSISILAAVHIVWIGGLLVANIYGILFTWTTNERVLQSRSQAKTSSLHSKFSRGVVQNVVDFFHFPLGDELDRIDWRRCRFYSLDELHARPSKAKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XYD1</accession>
    <name>A0A6G0XYD1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prefoldin subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_000020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000001">
        <property type="protein sequence ID" value="KAF0745565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XYD1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012440"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23161">
        <property type="entry name" value="Prefoldin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000003">
        <property type="entry name" value="Prefoldin subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431">
        <property type="entry name" value="PREFOLDIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="14"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0745565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="134" mass="14832" checksum="69C6D63A375F6815" modified="2020-08-12" version="1">MALAQQADAEMAAYRALQEEVSVLANQRQLYAQQQNENSMVKQELDLLDDNAKVFKLVGPVLLKQDTSEAKSNVSKRLEFIQNEMEKVEKKLAAKEEEAVKIRQNIAAIQMQMQKNAAESAGAAAAQAQAQLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W2E5</accession>
    <name>A0A6G0W2E5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Spartan-like zinc binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_019260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000595">
        <property type="protein sequence ID" value="KAF0720913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W2E5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016597"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044245">
        <property type="entry name" value="Spartan"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055220">
        <property type="entry name" value="SPRTN_ZBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21220">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE SPRTN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21220:SF0">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE SPRTN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22934">
        <property type="entry name" value="SPRTN_ZBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spartan-like zinc binding" evidence="2">
        <location>
            <begin position="36"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0720913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="166" mass="19129" checksum="73D8323391134A40" modified="2020-08-12" version="1" fragment="single">HGPQFQFHMNRINAMATTQITVYHTFHDEVDAYRVHWWQCNGPCRSRKPYFGLVKRAMNRAPSPRDPWWAQHARDFGGQYTNIKEPPPPPPKAEKQPEAKKFKRESNQPAIHSFFTPPARQVDRGDVKKPKLASVPRPPPPRAPQMEVMAPPPPPRIEIDLTIDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W3U8</accession>
    <name>A0A6G0W3U8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_019027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000376">
        <property type="protein sequence ID" value="KAF0721637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W3U8"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0721637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="74" mass="8301" checksum="04228FFF4A195FC4" modified="2020-08-12" version="1">MPKGLKGPQTPRDLKFRKGLHVPKGTQAPRDHKIPKASQIPSDRQTPRDFKPPKGLQITRDFKLPKGLEVLKGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W4F5</accession>
    <name>A0A6G0W4F5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_018812</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000358">
        <property type="protein sequence ID" value="KAF0721909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W4F5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016388"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15845">
        <property type="entry name" value="SNARE_syntaxin16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF83">
        <property type="entry name" value="SYNTAXIN-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="216"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0721909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="311" mass="35300" checksum="4520E0FA37C787B7" modified="2020-08-12" version="1">MATRDLTRAFANLRTDVKAKVARRRQMASHLPDVHHEANSLMRNAELRSDIDLEAAMSSTQNAPAWVDAVTDVNIHIARVKDLMDKLTKIRTKRLMVRFDDSETDQEREIESITADITAEFRKAEAILKSKMNAKDGLTDADAKTRQNVQRALATQLQTLSSDFRKSQKEYLDRVKNQRQGPKEFDFLSESSKPKRSTGIDGGFMQAQLAEVELAEDLINERDREVQQIATSIQELATIFKELAVLVIDQGTILDRIDYNMEQVVERTQAGIVELEKAETIQKSARPMKCIGILLVLITLMTIILMLKHLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W5V1</accession>
    <name>A0A6G0W5V1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_018423</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000335">
        <property type="protein sequence ID" value="KAF0722420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W5V1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014912"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12257">
        <property type="entry name" value="RRM1_RBM26_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045137">
        <property type="entry name" value="RBM26/27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14398">
        <property type="entry name" value="RNA RECOGNITION RRM/RNP DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14398:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN SWM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="238"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="447"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="80"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="197"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="331"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="121"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="226"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0722420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="522" mass="59222" checksum="13BF3F9BBD90609D" modified="2020-08-12" version="1">MSLDADAREMLREWLVRTLEPLCDADPSVLSKYVLALVQSNPEKDGLEEVCRSKLAEFLGDETSPFVDRLFAALRTQSYLQKSPRHESTPTGQAPSSSSVTEPTTESHRRPREDDDEPQSRSKRTRRSRSRSRSRSPRDRKSYNRDGPRRDQMHGGRGRGRGARGYDGWMQPPHMHHWGMYPRPMYPPMMNPDGFDPNAYNPDSPSMHGMPHHGSFGPPPPRRSKSNPEDGKKDDEATTLRVENVDPKFINMVKLSAHFSRFGEVVNVQMRPEYKAAFVQFATPESARKAFHSPMPVCNNRFISVKFAKRSPKDLGEIDAGSGPTPEELRAAALETGKKILEEKRQLVEQEKALQKQRETLLQNQLSQHEMLREKMAAKGLLRPAEQEKIDKKIADLKAQLHALQHPPQPQAPQQLANLHAELSQLEAKVKAGGHQRRGTSIDNRTKLVKLTNLPDAMRDASVLEQHFAAFGQIEKVRHDADVGYVKFADRYAGEKAMKFGHTYMDTRLEMTWCDDQNAIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W5Y6</accession>
    <name>A0A6G0W5Y6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_019141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000416">
        <property type="protein sequence ID" value="KAF0721428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W5Y6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014047"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF37">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0721428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="217" mass="24481" checksum="ED15895D1F3A598D" modified="2020-08-12" version="1">MLSFLLNGWVYTPDRVMQGHVDSALYVQATSEECYASVLLKHLLVWIDDILVYAKDPEDYIQVLREFFGLVDRYGFKLSPSKTGDGVRQDPARIEQLCAIPYPTNAGDLQQFICAVNWIRESITEYAMTVEPLQQALNTALEGKAKKKWIASGIKIELTQKEKAAFDAVKSKMRTAVDLSHPRADATLCLFTDASDQGWSIIVTQVDKFDDELPIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W6B8</accession>
    <name>A0A6G0W6B8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mannosyl-oligosaccharide glucosidase</fullName>
            <ecNumber evidence="12">3.2.1.106</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ae201684_018246</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(4)-(alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + H2O = N(4)-(alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:55988"/>
            <dbReference type="Rhea" id="RHEA-COMP:12806"/>
            <dbReference type="Rhea" id="RHEA-COMP:14355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:59082"/>
            <dbReference type="ChEBI" id="CHEBI:132537"/>
            <dbReference type="EC" id="3.2.1.106"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 37 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyl hydrolase 63 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.106" evidence="12"/>
    <dbReference type="EMBL" id="VJMJ01000327">
        <property type="protein sequence ID" value="KAF0722647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W6B8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011855"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005991">
        <property type="term" value="P:trehalose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.110">
        <property type="entry name" value="Glycosyl hydrolase family 63, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031335">
        <property type="entry name" value="Glyco_hydro_63_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031631">
        <property type="entry name" value="Glyco_hydro_63N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038518">
        <property type="entry name" value="Glyco_hydro_63N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412:SF11">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03200">
        <property type="entry name" value="Glyco_hydro_63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16923">
        <property type="entry name" value="Glyco_hydro_63N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 63 N-terminal" evidence="14">
        <location>
            <begin position="23"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 C-terminal" evidence="13">
        <location>
            <begin position="295"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 C-terminal" evidence="13">
        <location>
            <begin position="622"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF0722647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="782" mass="87615" checksum="771DCC37FCB1E324" modified="2020-08-12" version="1">MSAALFADCAGVATTGESIDEALRWGTYHSGLYFGVRSRTFPFHVSAGLLWSSTGSQLRHECLESDGLEQYGWQKHDGRHFGSQAIHDQHNNLLLETTFLKPLTSPTTFESRAWATRIAASTLRTTEGLPKTSSLFFYVDLGCEDDALENSCRANVLQGSQWTVNPPRSCRQPVDKKSCLEMELVSEHEEQTLAFHSRIQVHFRGDASLLNVRYFGDSSWNIINVKDKLAALASNPEVHRDAILDNSFDKSASFGIIQVRYDPSAVYDVTVRVLYEEQVEKDSTPVVVFDDLLPSLHERFDTQFSAAFPIHNPALVKLGQAALSNLVGGIGYFYGSTILESADKSIDRTPSLALFTAVPSRPFFPRGFLWDEGFHQLGIVAFDKDLTVQIMDHWLNLMDNDGYISREQIRGALAERRIPKEFVTQHTTHANPPTLLLALEKLIKLWFSWFQRTQAGSEPNTFRWRGRDPDDGKLMPNTLSSGLDDYPRASHPSYDERHVDLAAWMIKGSLILAEVADAIGDAAAAKGYRVFSSSYLEAMEALHWDSEDHLYYDYGLHSADGIFEDHVVIACQSSRGNSIQTTANIAILRSSGGDAGCPESHPRFLYPLGDGSGGLLTKQVFVPKTESLQFVKRVGYVNFFPLFLQTLPGDSPKLGPLAENLARHLLSPHGLLSLSPGDVYFERPNAPGDAPYWRGPIWFNINYLALTSFHYYAKHASDATIRQTYSRLYQYLRDSLIETVGQEFEATGYLYEQYNQRTGRGQRSHPFTGWTALIVNVLAEVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W6H9</accession>
    <name>A0A6G0W6H9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Armadillo repeat-containing domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_019003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000372">
        <property type="protein sequence ID" value="KAF0721670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W6H9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009905"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895:SF0">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0721670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="474" mass="51479" checksum="157FC422B310AE11" modified="2020-08-12" version="1">MATAKPKKIISQETFNECVRENMEEFDMLEADAIADAIAQFESQGVDLSATVKGLDVVHPVVEALQAIQYASGDVSVHLLALQEQFRSVEDGVAAKELAGRNQGPSILLDQLSTTTHDARTKIQLLLTLQSMVTGVKDNQNAVGEHGTALIYDTFLSSNDVETQDAALGSFKAICARNERTKKLLTTHGVVARLVELFQERDGGTKSTKPFAELIRVLTIHDDSDSIFSQTHDIVKAFVEKGLIELIVPSIRRSSPPEATWLAVLKQVAITEDNCKKLVAAGILDLVHLHKDDRALLTHSLGLLRNLAAVDEYKSVVTSTSMEWILATMAQNPTEVQIQTTACATIAAVCLRSPANCTSVAQLGAHRWIGSAMVQSSSNISLLRQASLAIRNMVVRNPELRQVVLEDPVVEKQLRNAMPLRGCGDEAYAALRDLGADVPLASIGQSHANFNPVMESSSQLMSTIQENAHAPFED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W6I7</accession>
    <name>A0A6G0W6I7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_018200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000326">
        <property type="protein sequence ID" value="KAF0722721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W6I7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000630"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="3">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0722721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="182" mass="20015" checksum="8560C7FF96EA99AF" modified="2020-08-12" version="1">MFATHPEMEALARKECQAVAAASDGGIIGWKSLGELKYTTAFIQETLRLHPTITIIAPRACVQGDHVPMSDGKSIFTTKYWSQPDEFVPERFLEGTAPFEADKALRNGQGNSYTYLPFSTGPKNCIGMRFAMAELQVVISNLLLQFSFRLTDKANVNPRLDGVSLKPVHLSMTIHSVAASSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W725</accession>
    <name>A0A6G0W725_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_018023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000319">
        <property type="protein sequence ID" value="KAF0722946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W725"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001364"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053218">
        <property type="entry name" value="Pathogen-related_defense"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31723:SF10">
        <property type="entry name" value="PATHOGEN-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31723">
        <property type="entry name" value="PATHOGENESIS-RELATED FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="13"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0722946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="301" mass="34415" checksum="9C9B7199449A2ADA" modified="2020-08-12" version="1">MFMDDVATNTLRPVKHAGWLRFRGPFGLWTRRFCLCKGDFLHLYKTDDIINGKLKTSIQVWRVDRLDQRWNFRVSDAHGRVMIFQSSDAALFSRWMQVLREIAKENDQDEHDAAMVIPVSSRSLASRPSSFLDKENPALDTSTLFKTSGKASMESPTGKELSISWGNPHHAPHSMEHRMEILMRQWLDEVSSTAPRQAWQTCHPQFYRHTFNGKLHDGVPELFSTAFPRGFGWELSAICSGPPRVAFTWRHWGTFHGTFQGHCGDGRVVELTGFCIVDVDALRLCIYTLDMYCANADALTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W7A8</accession>
    <name>A0A6G0W7A8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_018764</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000353">
        <property type="protein sequence ID" value="KAF0721983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W7A8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014088"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050889">
        <property type="entry name" value="Dendritic_Spine_Reg/Scaffold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166:SF48">
        <property type="entry name" value="PROTEIN VAPYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166">
        <property type="entry name" value="ROLLING PEBBLES, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="53"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="86"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="119"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="152"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="185"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="218"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="284"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="317"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0721983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="457" mass="50362" checksum="5CD400754A5A8F9B" modified="2020-08-12" version="1">MKLTKRRSHLLIRFQIFGSTSSLELLGKSCVYLDQNCILRTGVYHECKPDSRLEEAELEVALKNGHVDSVRALLGQGLDANLKDANGETPLLQATRQGHFDIVQELLAHGADIKMADKTDDTPLHIASRNGHLRIVNELLAHGLSVEIRHANANTPLHMASSRGRYLVAKASLAHAASISSPNQNGNMPLDNAAANGSLEIVKALLALGCALNVKNAMGKTPLHEAAHFGHLQVFNELVADEADLDAKDNNLNTPLLTATWCEHSNIVHHLLTRGITEHERNEFSSTQLHEASRNGQVKTVEQLLAHGARVDIANNDGFTSLHWAASNGHTVIVKVLLDHGAPVDTVNANRDTPLHLAAENAKVEFVHENDPSVNSMKKTLNFGRVIASTNRQVDVLQLLLDARAKRLLRNKDGKTARDLANDDVQAWFENYQEMANKQRQQRVSHLFKAKERSQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W963</accession>
    <name>A0A6G0W963_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_017413</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000296">
        <property type="protein sequence ID" value="KAF0723741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W963"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019264"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF288">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="31"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0723741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="289" mass="33122" checksum="085326A4F2F0FD7E" modified="2020-08-12" version="1">MAKETKTLNSDYGNMLEPWMLSMDDVQFDPSNLNSIIGQDTVGTVFKGSYHGEAVAVKQFHSINQVDSVELKELIANEIKVWAKISHEPYILTLIGLCKVPRPILVTELCQTNIRRYVRDWPETLLPMVYQFAKGLATIHNANVIHRDLKGDNVLVTAQKTVAIADFGLSRDGNATMMDDDQVRGTLNWMSPEQYFKPQSVTTKSDIWSFGMTLWEILNNETPYRECSEYEFKDIFQSDDDRPEKPQELAPMLEPLWSLITKCWQLDPHARPSAVEIVAFFEDHYNSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WA42</accession>
    <name>A0A6G0WA42_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RxLR effector protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_017153</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000282">
        <property type="protein sequence ID" value="KAF0724102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WA42"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014710"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026058255" description="RxLR effector protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0724102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="125" mass="13846" checksum="69281CA464DE4E9E" modified="2020-08-12" version="1">MRIFLSLVLAATAVLAFHQEQVNEPTVFEAPRALSAELKATASAQDETMRELTAAGRRRGRRGRRRRSLFGLGGRSRGRRGLVSVEEAQDEADETTRELTAAGRDIARRGRRDGLRERSNGARNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WAR7</accession>
    <name>A0A6G0WAR7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphoglycerate mutase</fullName>
            <ecNumber evidence="8">5.4.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_016984</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.11" evidence="8"/>
    <dbReference type="EMBL" id="VJMJ01000273">
        <property type="protein sequence ID" value="KAF0724322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WAR7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021482"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004619">
        <property type="term" value="F:phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000003">
        <property type="entry name" value="2,3-bisphosphoglycerate-dependent phosphoglycerate mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01039">
        <property type="entry name" value="PGAM_GpmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005952">
        <property type="entry name" value="Phosphogly_mut1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01258">
        <property type="entry name" value="pgm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010713">
        <property type="entry name" value="PRK14115.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11931">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="5">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="11"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="24"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="90"/>
            <end position="93"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="117"/>
            <end position="118"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="186"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0724322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="259" mass="29043" checksum="E41DA3AB84547A04" modified="2020-08-12" version="1">MAAKYQIVLIRHGESQWNVDNKFTGWHDVPLSAAGEKESHEAGKVLKAAGFKFDVAYTSKLKRAIKTLWNVLEELDLMWIPVHRSWKLNERHYGALQGLNKQDTVAKYGIDQVMVWRRSYDIPPPALDESSEYYPGNDPKYADVPREELPFTESLATTKLRVLPYWNEVIIPSIKEGKKVLIAAHGNSLRALVQYLDDISSDAITGLNIPTGVPLVYDLDENFKPVAHPLAIGPLSGHYVGNQDEIRARIAGVANQTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WAV6</accession>
    <name>A0A6G0WAV6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">U3 small nucleolar RNA-associated protein 25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_017692</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UTP25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000309">
        <property type="protein sequence ID" value="KAF0723350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WAV6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004774"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010678">
        <property type="entry name" value="UTP25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053939">
        <property type="entry name" value="UTP25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053940">
        <property type="entry name" value="UTP25_NTPase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933">
        <property type="entry name" value="ORF PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06862">
        <property type="entry name" value="Utp25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22916">
        <property type="entry name" value="UTP25_NTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UTP25 NTP hydrolase-like" evidence="6">
        <location>
            <begin position="295"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="UTP25 C-terminal" evidence="5">
        <location>
            <begin position="584"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="67"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="131"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0723350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="774" mass="88952" checksum="4A177DECC1DD355D" modified="2020-08-12" version="1">MAKKKGGKRKRTQWDDEKDVPKKQRGVVDDNEPRKKGRGESMFSQWKKQKQELKQKRRQYESAIAQRKQEQYYRLKGEKSYDSDEHSELDNDAHQEGETSDDDEDEDDDNDKKPSTFQAFVSLFQRQQPSFDEENEEDGDDDEVEEVLEEVDEEAENDDEDEQVVEADEEAAVDEIEAVGDIQEDEAEEDEDDTPVEAHAGDEDESDPYRQRYLKQELTASDVERLSQKPSPFQIVDQWKDLEVSVRPTLVPAAEMSGARPLTHIRQRLLDTWTKKDLANLTPLQQLLNGALQKYQDLVYCNQTTDNIAKIRRIAMMHVVNHVLKSRDTISRHNERLSKASDDAEYRDQGFSRPTVLLLAPLRSAAHSLVHEILDLLPSTVTVIHNKDRFDEEFGVQKDEDEEEDDKTIEEGTEWQKIFQAGNNDDAFQVGISFSRKTVKLYTDYTRADLIVASPLALRQKLGDVVVDLVPGDKSSLKLPVDFLSSIEICLVDSASVMLMQNMDHVRAVMNAINVTPKEAPNADFSRIREWNLNHQAHYFRQTILFCHAADAQINNLVTKSCHNLGGLTRIAPVYDLQHVVPSVSHVIPTIKQIFQRLDVPSQPASCPLAQEPDIRFKYFEQHILAPLLDHPTKHTMIFVPSYLDFVRLRNVFATQKRLISCAAISEYSTDSQISRARSRFFHGQIHVLLLTERFHFYKQYRIRGVHQIFWYAPPSLGPFYAEVLNAIEPEDETKSVVLCSRFDTLRMQQIVGTKKAQRMCASTADTKSVYMFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WDL1</accession>
    <name>A0A6G0WDL1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ADP-ribosylation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_016867</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000270">
        <property type="protein sequence ID" value="KAF0724460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WDL1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000353"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00878">
        <property type="entry name" value="Arf_Arl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000412">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="26"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="128"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0724460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="20629" checksum="4077323795C5D368" modified="2020-08-12" version="1">MGAFMAKMKSVLDSFSSKRRRIIMVGLDAAGKTTILYKLKLNETLHTLPTIGFNVETFQYKNIEFTAWDIGGQDKLRPLWKYYFQNTDAVIFVVDSNDKHRVDQASIELHRIFQADELRDSKLLVYANKQDLRDVMSPAELVEKMNLRTVTSNPWFVQPCSAVSNSGLYEGLEWLAKTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WED1</accession>
    <name>A0A6G0WED1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WRKY19-like zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_016625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000264">
        <property type="protein sequence ID" value="KAF0724751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WED1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003828"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056866">
        <property type="entry name" value="Znf_WRKY19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827:SF1">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24906">
        <property type="entry name" value="Zf_WRKY19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WRKY19-like zinc finger" evidence="1">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0724751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="176" mass="20033" checksum="BF364E9B28CD55B1" modified="2020-08-12" version="1">MKCFFNDCENPTANGTWKCTFHRHRSLCLVHNCQNQVYARNLCVKHGGKPKCQAENCTMNSRVGNFCSRHGASHLKKRCSRDGCDKQAHARGFCVRHGGGRKCRIDDCTCHARNGPYCARHKCEIEDKMQKEPVQRPLHVEPLRLPSLHAQLAKPDEQPALPRFPTPLKMLMSVIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WF57</accession>
    <name>A0A6G0WF57_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine/threonine-protein kinase BSK1-like TPR repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_016404</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNA polymerase II subunit 5-mediating protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000253">
        <property type="protein sequence ID" value="KAF0725006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WF57"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015275"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019212">
        <property type="term" value="F:phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23159">
        <property type="entry name" value="Prefoldin_URI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052255">
        <property type="entry name" value="RNA_pol_II_subunit5-mediator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058209">
        <property type="entry name" value="TPR_BSK1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00293">
        <property type="entry name" value="prefoldin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15111">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT 5-MEDIATING PROTEIN NNX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15111:SF0">
        <property type="entry name" value="UNCONVENTIONAL PREFOLDIN RPB5 INTERACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25575">
        <property type="entry name" value="TPR_BSK1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Serine/threonine-protein kinase BSK1-like TPR repeats" evidence="6">
        <location>
            <begin position="216"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="243"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="311"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="342"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0725006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="416" mass="47456" checksum="08BA818DAB2617DF" modified="2020-08-12" version="1">MTNYAKWDRILRELVEDDTEDDTSSKPKSEQFPPRSHKPFQLKQEIHEAAEKLHKLEKDLAEYEELGKVVKDLPLKLDHDIMVPLGKQAFIPGKIVHANEILAHLGGEHFAKKTASETYDMVERKKKNLTKQIERQETWLKSLHEKLGDVDHVLQLKKIYEDANIQEIKETEEESNEVFDASEFTQEDYDTYFEIEKQEAEKLASSAWDWDEAMRRLEELEQNEDGDATEETVSAIQVKMNEADQVKQQGNAAFASGNYSSALELYTKAIDLAPTSHTLFGNRSAAHYHLKQFAEAKRDAEKAISIDPTWAKGHFRLGQALAATGHYEDAAKSFEEAARFKPSDKSSTTMAAEMRQKAENEQRLKQLSARDKERSSVFTGTVVERGQNEVNAGNTVAEQPPKRVSRFKAMRQGQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WFM5</accession>
    <name>A0A6G0WFM5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cellulose 1,4-beta-cellobiosidase (non-reducing end)</fullName>
            <ecNumber evidence="3">3.2.1.91</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ae201684_015489</name>
        <name evidence="16" type="ORF">Ae201684_015490</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains.</text>
            <dbReference type="EC" id="3.2.1.91"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 7 (cellulase C) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.91" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000222">
        <property type="protein sequence ID" value="KAF0726213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VJMJ01000222">
        <property type="protein sequence ID" value="KAF0726214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WFM5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018709"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016162">
        <property type="term" value="F:cellulose 1,4-beta-cellobiosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07999">
        <property type="entry name" value="GH7_CBH_EG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.100.10:FF:000001">
        <property type="entry name" value="Glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.100.10">
        <property type="entry name" value="Glycoside hydrolase, family 7, domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001722">
        <property type="entry name" value="Glyco_hydro_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037019">
        <property type="entry name" value="Glyco_hydro_7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753">
        <property type="entry name" value="1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753:SF2">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00840">
        <property type="entry name" value="Glyco_hydro_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00734">
        <property type="entry name" value="GLHYDRLASE7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033536787" description="cellulose 1,4-beta-cellobiosidase (non-reducing end)" evidence="13">
        <location>
            <begin position="21"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="14">
        <location>
            <begin position="513"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="458"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF0726213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF0726214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="551" mass="57700" checksum="C638C39BEA52C50B" modified="2020-08-12" version="1">MKAAATIAYLATALVAFSNAQQIGTNSPEVHPSLPSQTCTSSGCTTENTKIVLDANWRWTHNVGGSTNCYTGNKWDATLCPDPATCAKNCALDGADYTGTYGISASGNTVSIKLVTNGPYSTNVGSRIYLLQDDNTYKIYKLLNKEFTFDVDASQLPCGLNGALYFVQMDQDGGKSKYTSNKAGAAYGTGYCDAQCPHDIKFINGEANVKNWVPSTGDPNAGSGQYGSCCAEMDIWESNSISQAYTSHPCTVTGQYRCSSPTECGDDATGNRFDGVCDKDGCDFNPYRLNNHTFYGPGSNFNVDSTKPVTVVTQFITDDGTDNGNLVEIKRFFVQNGKAIDNSAINWSGIDATNSITDKVCNQAKTVFGDTNDHSKKGGLKAMGDALKKGVVLTMSLWVDYAANCLWLDSTYPTNKSPSVPGAARGTCPTTSGVPADVLAQVPGATVKYGNIKVGALGTTTGGVKPPTTGPTSAPSNTPSTSAPTTRPTSAPSTSAPTTRPTSAPSTSAPSSGAVGAWGQCGGNGYSGPTTCVSGYTCKSYSEWYSQCIPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WFV4</accession>
    <name>A0A6G0WFV4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 11">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="1 11">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ae201684_016131</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="11">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="1 11"/>
    <dbReference type="EMBL" id="VJMJ01000243">
        <property type="protein sequence ID" value="KAF0725360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WFV4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010169"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07852">
        <property type="entry name" value="STKc_MAPK15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000238">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000166">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="13"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="349"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF0725360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="365" mass="41453" checksum="9FC6125538F7AFF0" modified="2020-08-12" version="1">MGEEVEKHILRKYDLLQKLGKGAYGIVWKAMDKTSRQPVALKKCFDAFRNATDAQRTFREVMYLQELNGHNNIIRLLNVIKADNDRDIYLVFDFMETDLHAVIRANILEEIHKKYVTYQLIKALKFMHSADLLHRDIKPSNLLLNADCHTKLCDFGLCRSVSELGGPNPVLTDYVATRWYRAPEILLGSTRYTKAVDMWAVGCIVAEMVSGRPTFPGTSTMNQLERILEVTGTPTAADIDNIKSPFAATMLESLPPPKTQTLEELLPKATPEAIDMIRKCLHFDPQKRITAEEAIKHPFVSQFHNEKEEPVATAPCQIVVDDNTKYSAADYRDRLYREIIKKKKEVRRQSTSVPPDAANSTSTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WFY8</accession>
    <name>A0A6G0WFY8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_016093</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000242">
        <property type="protein sequence ID" value="KAF0725452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WFY8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013149"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="651"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="442"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="612"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="661"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="676"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0725452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="696" mass="80602" checksum="15F48666D08F5377" modified="2020-08-12" version="1">MRDLASAFEHERQALVKDLETMRQQLIRKDEQSKKQAAVASSQLIALKKEVADLQSQRALVDKESEMYAQKCKDLTTLLETSYDQHEEDQTKIVKLSENLKRLKKKYDDGLELAKREATISIMNTHEERKSLKANAERLRCKLNAERKEWLDAKQALVEQMEECRAKAETLERELKEARLNDRSHRMSHDQLTAEIRSLKHDLSSARQDHAVAKVAIEKYKSEICRVVEETRVQRDSDQTLVERLQMSQEDATMNWRRRATLFHENCSLKQDLYAAQQKYDALVAKRKQERAASAMLSEELSDVRRNTKRMSIAMEEQSAADAQRLKRSHHEAIQQLKEKHAAELLQLQVDGERKLAKVESAHRVLLEELHETHSQDVQNARQVVEKQMQTAVHQVQALCESTQHQLVSVTKEKEMMEIQVGDLHREIDAWRDKEKRLIQIMEHAQKMNATLEERHVGLECKYLDAQKQIDELMTSIKSLQSTIANQRDLVDEMERSRQTKTEEFAREIACHETEKLECMREIAQLHEQHSQDVLALEILKRNHDHTVKQLTQGQMSANRLIEEQAATIEDLLVSRIAETPNNSTNKGPCRRPECQAIAHELLDFKSSNAQVVDLHTLLVQTNRQVQALEAEKATLQRMLDDQAVTIHELTMQDDDGDHPEDDKWNDPLEDLHRISSSPCPSSPSSRRRQEVPQPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WGA4</accession>
    <name>A0A6G0WGA4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_015809</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000232">
        <property type="protein sequence ID" value="KAF0725847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WGA4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019414"/>
    <dbReference type="OrthoDB" id="15688at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12324">
        <property type="entry name" value="RRM_RBM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008111">
        <property type="entry name" value="RNA-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033744">
        <property type="entry name" value="RRM_RBM8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45894">
        <property type="entry name" value="RNA-BINDING PROTEIN 8A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01738">
        <property type="entry name" value="RNABINDINGM8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="55"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0725847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="149" mass="16600" checksum="BF134B0A0C9297AD" modified="2020-08-12" version="1">MSESDSKRGDGDSKRKVKGRGQHSAGLASSRSVFDRLDQGESKAAVVGQKSVEGYVLFVSNVHEEAQEEDLLDAFQEVADVANIHLNLDRRTGFVKGYALLEFKELEDAQEVIKEMDGKDILGNQIHVDWAFIKDDAKRANAPPRSRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WH99</accession>
    <name>A0A6G0WH99_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Vesicle transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_015190</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the SFT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000213">
        <property type="protein sequence ID" value="KAF0726565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WH99"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020938"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011691">
        <property type="entry name" value="Vesicle_transpt_SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137:SF36">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SFT2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="45"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0726565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="244" mass="25961" checksum="608B5777B9D71C32" modified="2020-08-12" version="1">MELSAANVRAQWGAAASSSSSNLAKSFSAATSSLSSWGQSFLKNNGPLSPSDTASLTGDESPDLESGVDSPAPSPSSLQSLWSNIKAQTTPVHMDNMKSYPQRFRQFVMLLLLAVLFFGLASLFLPLLLVRPSKFALSFSLGSLSCLAAVAVLRGWKSYLLSLLQADQIIITTLYLSSLAATLYSCLVLGSYIYVVISAGMQLITLAYFLVSAFPGGVTAFQTLGKVVIKTARGMTKTCSKVFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WHB9</accession>
    <name>A0A6G0WHB9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone chaperone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_015196</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ASF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000213">
        <property type="protein sequence ID" value="KAF0726571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WHB9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020944"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006337">
        <property type="term" value="P:nucleosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1490:FF:000001">
        <property type="entry name" value="Histone chaperone ASF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1490">
        <property type="entry name" value="Histone chaperone ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006818">
        <property type="entry name" value="ASF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036747">
        <property type="entry name" value="ASF1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017282">
        <property type="entry name" value="Hist_deposition_Asf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040">
        <property type="entry name" value="ANTI-SILENCING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040:SF0">
        <property type="entry name" value="HISTONE CHAPERONE ASF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04729">
        <property type="entry name" value="ASF1_hist_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037759">
        <property type="entry name" value="Histone_Asf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101546">
        <property type="entry name" value="ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="198"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="206"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0726571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="26052" checksum="771C9FD2E86D81F2" modified="2020-08-12" version="1">MAYVTLTNITVLDNPTAFTNPFQFEVTFECAHPLEDDLEWKITYVGSAEDESRDQVLEEVLVGPVPVGTNKFVFQSEPPDPAAIPEEDKIGVTVVLVTCSYKSREFVRVGYYVNNDYTDPFLLENPPPVVDIHKLQRNILADKPRVTRFPIDWAPGSAAGTGTEFGQQGPNGVPVVESDMLNEDELIKAAAQLDNLHPDIVIGEPAEGDDQDMEEDDVDMDDEDADSGIEFEEDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WHK5</accession>
    <name>A0A6G0WHK5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_015154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000212">
        <property type="protein sequence ID" value="KAF0726645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WHK5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013507"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="53"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0726645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="166" mass="18644" checksum="0F6D998EB037FA2F" modified="2020-08-12" version="1">MPPQAWWQVAQFTHFAASVGDHLPKTYKAAMESGNAGKWSEACKAEIKSLLENKTWDVVELPEGRKAIGCKWVFKIKERADGSIDKFKARLVAKGYSQEYGIDYEETFEPVAKFTAIRVLLSTAAKYNIDLQQMDVNTAFLNSDLDEDIYMQVPDGLDVKATQGQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WI81</accession>
    <name>A0A6G0WI81_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_014908</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000204">
        <property type="protein sequence ID" value="KAF0726916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WI81"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021079"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026049374" evidence="2">
        <location>
            <begin position="20"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0726916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="214" mass="22777" checksum="64FF7AE8307ED3EA" modified="2020-08-12" version="1">MACRARLVALSALVVLARGEDQSSLPPHVVWVVGLGAVSVLVVVWAVCWCRRMSRQEAFLPVSKPQEPQVQLRSEESSSSGGFFAWKEDDATCTLEKPIEIIDEIGSCSSSRFSGYVMHTNTSMALSSDVAASSDVAASSDISASSEIAASSEIGASVGSSNFSGYLSTTSDDVSEVFSDVRVTSRVLFDPRSKTTTMFFSVDPVPSSTARVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJL5</accession>
    <name>A0A6G0WJL5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_014522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000196">
        <property type="protein sequence ID" value="KAF0727434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJL5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017344"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0727434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="164" mass="18070" checksum="6D1051D1B4B0A0D7" modified="2020-08-12" version="1">MDAVRGDDSVPSAQGLKRSSATVEEGNPKRSRTDNSATPTDSKQHGIEEKPSSNTMIVPAPTAAIPEPSQGELMAIHSINQKIKSLNWKLVEKELEKGMVYLGDASLSDWEAFVTSEDQQLKSKNMEWIDGKIFTVELPSQEHETYVGNCLLLSVMQLILEVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJN3</accession>
    <name>A0A6G0WJN3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GP-PDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_014483</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000194">
        <property type="protein sequence ID" value="KAF0727461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJN3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021646"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="2">
        <location>
            <begin position="493"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="968"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="981"/>
            <end position="994"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0727461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1024" mass="115546" checksum="D4BF15D5A3F7CE6C" modified="2020-08-12" version="1">MDETLALASVGITHLGNSRHNETLADDFHGLHTKRADSRTKLKARATEIQAKWLNVRFRTLSLVPTLELPDFIFHENYDVDVLPSSAPDSAGLAKEIAAYRNELDRRLNESRKQERLQATESTQHQQSSEARRKRELYAQQKRFEQAQHRWNSLSKKMLQHQRRMRRAAVKLAYARDEYAQDYEDIRSMFSKRRKLLRPFLLKYIATLLNQATLRATWASQMQPKQQLVLSATPATCRVVRLAMLVCPNPFGINYAHLYQRFFAKHTGDCNVVIEWTVFDIAAMEFPSRAAQRCADGFFIGGPPNVTEAPDHARRSSQWYPSLLALVRELVSQGQIVGALGQGHLILAEALGGRIETRPLWQRAHNVIEEKVLVQGRPQTRVRVVHSLHGEYVASLDHALVRSTLSLPVPGTMHSFVSSFKTPTLRLLSLDGYPECGNLIFTLLRMFHQENVPSESGSSSLALDWVSAAPSVARQFIQLFESTSYQSNGDLPPLLHDGRTSPVDFFAMKASTPHTDFISDTEEFVTFAAHEHATAIVLGVSLSNDGYPIVFPHCALSDLTDVREVLPSSSERENICIQHLDLLQLKTLTILHSYQRRHVIKSPRKVPGSKSSSAHNRLLTLVEVLHTVNALNHGGSSMRVVVKFPQEELEMVSHLDMERYWAALIGALNATTEIEVTVVSFDAMLLRVLRSMRPTWEFILAIPLNRNPQDGFFVRHQAKAVARVADGILLFMAHALMCGYPCSDRIQPVAVAGLYREAGLRVYVDANDSQSVCVLQEAQEKSPVRDQLALLLLGVDGVFTSNPHPVQDAWKFFQEKHAIVEEVRQAICNYGCTMAAQMEADMHKHDQVYHHYAHHYYKEPQELHNQERDNPIGDDVLQLIARLGQVDIATEAARQIQAHDRYHCKPIAVDDEQSSRRENIRMAVKAPILDKVRWVKREAPPKGKRSRGFAFRSPLAPAQDWRDGNAVLSVHHSPMPPTARPSRRGRGHAHRTIKAHPTSPSTTSSDENESRRVVFHSISLPACT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WK21</accession>
    <name>A0A6G0WK21_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vesicle tethering protein Uso1/P115-like head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_014432</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000193">
        <property type="protein sequence ID" value="KAF0727607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WK21"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021627"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048211">
        <property type="term" value="P:Golgi vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024095">
        <property type="entry name" value="Vesicle_P115"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006953">
        <property type="entry name" value="Vesicle_Uso1_P115_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013:SF0">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04869">
        <property type="entry name" value="Uso1_p115_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vesicle tethering protein Uso1/P115-like head" evidence="6">
        <location>
            <begin position="421"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="12"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="773"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="953"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0727607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1048" mass="117225" checksum="7BF19B9C91E0ECA6" modified="2020-08-12" version="1">MMTHIMKRFVESSASAAESLQGNDQPNDVASDLPRNSDRNRPPSAREPTPPSSSKAQPRRSVPKADLAVAIERFQYAMLLVERKSAVAQLQTLWNEADIPEESHRLIIPVILNALVSDPRDTELMESMLELMQAIVTVNPANATILLQEPHALDTILGLMQDPSPWIRGPTVQLIKRVQDGDSAGFATHILACPQGLRLLLEVVEDKREHIRDTAVQVLLNMTTNQTPMTQRHVQQFLAFEEGFARLFQIVDLELEGHGIESPVLADCLQVILNMIENNTMTQSLLRETPFISVLFPLLLGAGLPDPAAAEEAMPSTRPVGMKSTLDILACLVGPVYANVQGEALDEIAKRDQAKRNDELPLVQAFLAQQYEVVQMLGELACHGADADRIDALNVLHLMCQNNEANQLMLLTLTVSGPAYLLSKCLELDVHHEETPLGAASRTLLNCVWNSDLAKISILQHIHAPPPHENGPIEPLGHVLVSKLATTLESILTNETVALSLTPRDATKVVWKCCARWRSLMHNSECKLLALRVPGPNQTHATSGSYFLNTCLKWLVEISWTKPHYSLLLALFRLILSWIQGCPPAIHEVVTSVPTLTYFCKAMDRPKSIDDLEIEMAGLSAMLLGTCLEGLDGKTIQLKKEQLLNMITRQVGLQKFTDAFVNFQQLSNFRDLKRSPDGFVVYDKAFAQLYKHVAETTRVGIMNVYMGNDKDEDSRAKAYQDLIRMQDEQLHALQEQLKQKPGGGVNPLEGELQRANQFIAELKHIQETNEARIRGLTQSNDLVEKELQRKEAELKKLQSGALPQAAPVVVKAPVVDNSKHELRVEKLENEVLRLNRLLDEKDEELDASRQTIDLLTAHQNLISQAATDKHDQQTQSSFVDEALTAKVAALEQELEKAQATHTTTVSTLVARHEQQLKQVEHDFKLKVDEALQAQLKELQQKHDVEMSALRISQDKSQEEVKRLEAVFDQLQKETEKMHQMEAELAKLRTASMERESDDELLMLLGSMEIQCRSFREVLEQVLGKEGVDKALKLSQDRGAVSFLSSFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WKQ7</accession>
    <name>A0A6G0WKQ7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_014175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000187">
        <property type="protein sequence ID" value="KAF0727833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WKQ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006070"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169:SF2">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0727833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="37455" checksum="DF5B79605D8B87A3" modified="2020-08-12" version="1">MKSQGRLKKRSNSLKPYLTKDNKKTRLEFALSFVKPNQVFDRMYDVVHVDEKWLYLTKLIGKYYVYDDEQLPTRHVESKRFITKVMFLAAVARPRFDFHSHKYFDGKLGVWTFVSREPALRSSVKRPKGALITRPLSVTADAYLDMLTSKVIPAIIEKMPPSARTRTVFIQQDNAGPHSSKVNKAICEMDCSDGWNIQMPNQPPNNPDFNVLDLGFFNAIQSLQYQSTPSNIDELIDAVVYSFGALPSDTLGKTFVTLQKVLQISIDIEGSDAYKLPHMNKNGTIEDLSTFNLSCEEDSLVLALSKLNRRLEDESNLEDLMNCLDEVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WLB1</accession>
    <name>A0A6G0WLB1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_013938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000181">
        <property type="protein sequence ID" value="KAF0728110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WLB1"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF214">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0728110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="124" mass="14019" checksum="42EDA606A3C134D0" modified="2020-08-12" version="1">MMLLAEFMDGGDLRQVLEANNTKRSFTWTHKIHCALNIAEALVFLHSMDPIVIHRDLKSRNVLLDADFNAKITDFGIAREVDETTLTAGIGTYRWIAPEVLVDGDRPTSLQAAYQIRCRIEGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WP07</accession>
    <name>A0A6G0WP07_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_013243</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000169">
        <property type="protein sequence ID" value="KAF0729107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012140"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="658"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="703"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="748"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="775"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="831"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="962"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1563"/>
            <end position="1588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1664"/>
            <end position="1686"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1698"/>
            <end position="1719"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1739"/>
            <end position="1764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0729107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1861" mass="208631" checksum="74CE9F4AB2BB3E8E" modified="2020-08-12" version="1">MNKVHSNSIGRETTTVQQDGLTSSELVRPTDTGHFELTSSASEQSTIDNTMSTYEIAECICGLLYLGLTLAMSLRYLQMLSPSMANDLWWSGFNTSGVQTYLIDVYNAQLNLLGNQTQSIDVTDKQFGIGKDYSQFYTPIEITPAYPRLLFNVMAYDLAAFVVALRQVPGLEYISSQFCWVDFNRSWEVAHTVMRQKRCNARYIDNGAVYLEPIVRLTDWNTWLHGVYGGAFNSTIGDAISRTPEGQAWLRDTPYAFTSIEAEVMQWRKVGITRYSVQFNNYYTYGMTETFGVQNALGVAQHITIKRKASEVRNGGWTTMWMYFGLWSDFLYADWYGYSIVINDRANQRFTAPCSYVDYVQDPANYSCDPCDLQWNPDAANCSPNYEMFLGLPNTPTFDLVHNNIGPLNSIDLYFVAPPRSLVKVYTTFQAILTELHFSNKTFAATMAAIPTLASDPIPPTWLQPSLMYLGGDPTCLFRSPTPFVQSYYSFDVTCSSKDSQLMTLTPEMAMFALWSTNQTNISDICKICPQFQDHCTSVLHAAIESTHLLRQSYENSSLEIVQSAYKDVVALNVNTIQFSINVTDLTNVFLRQPVLGGQLSSPWDVFGWMYLFEWVQGFREVVSFEGDVNILPLLSNRYEPILNQAESLEVPSSACQYLWVVAVVVTTTLVLVGHLVLIYCLRLRGRIVGRHLFQFNRIVGSVWLNRPLLFVRSLTAVILLSTSPLIFETRHGHAKLNANPRTYFESMLVAGEATWISYITFDFLLVLTPKSSPFLAPFTSVASWIALIVMDVCFPYPITANLNRQCCVDFIGKKLSCTVGMIQVGSLNRAVLLVVSQIAVVFITIMVGYACTWTRTSRLEHSRGHLLLSGSVLGFLHMQPNDHWVLDRASCAMCGLITYHQSLFDVKLWLLVTDKAKAHTKWGMKRFDHAWLNVHDALRKVQTKGPPVVLMNRPMKMKNRLVALAGLVYVIATLFGSVTFLTLTSTNMANDFWWANYSAMREHIYVSRLLNSQSTLRPHAGSISLSDDKFLDDANYSTCSSGQIGTIVKQLYSSLVLSTDGTDLASVIHGLRSMDGCLAPWISSQYCWLDFDKRWEMANSPARQIRCANNYSTNAAVYLESVLRNVQWPQLRSCWGTSLDIALGAPLKNLPNGTTWWKSVQSAKIPDDDELQHWHSFGLTTYAIDWQNYKSIGIIESFNIRNAFGLSYRMALKHTNGSFNLVAQTSMKMYWSFASDLWAVTDPSTSVYGASLIRQDGSFAFRNRSMESLLIENGTLRDSDLTIGAAFSAFRKTIGPFGSVDLKRVPVPPSMLAFSVYFMDIAAQLRIESTDFATFWIGRPPLLETWYMPPPWLETNTPKAIGGNLLCKEVPTADESSGLYLLTGASSACGTSVGEHIKIPRLSNLFALIGANLVRSNLTTDFIDDVCATIQTVDDFSCKDEYILPSLGFLLNDSMVDPSLLTNLRSMAEVAQNDMHALVVEINQYGRTVNGTAVVMRHEIFNPTYPSFHYIAWVLAMEWATNNREVISFQGNIGSANVLTARSFDVASLINPLEIPVNVAYYIRYVCLYVTVFVISVATLATLYLLGNKGHVEGLNLFAINRVVGIVWIGRTFLFIRSMAAICLLSTQVLSLENVNDLWRLVDATHLAHESSIDRSLRIFKTILAAGEVSWLCYVLSDILTLLTAQYTTGYTMKCTTLVWIVSASISLAAPATHVATLQRECQYAQVDFQLICTSGTIAIGSFGRFLLLVGICVGSVALCYLYERLCHPSLPPCHQTSLFLSASAKYIFRRDEWIFDDVYYIDPASAAINGILSIQVGSTFCLFDLKTWRLFAINVSKENRERIKQEGKLHLLSSIPLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WPB0</accession>
    <name>A0A6G0WPB0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_013164</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000167">
        <property type="protein sequence ID" value="KAF0729187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WPB0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007606"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827:SF1">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0729187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="182" mass="19861" checksum="01119A0EF4CE5A31" modified="2020-08-12" version="1">MQATPLCMFQGCQNAATYYAKCDVHKHRTKCTTPSCENQTYARNRCVKHGGKPKCLYNGCDANVRSQGLCCRHGPGNVKSICQVDGCVKVAHARHRCVRHGGGLQCKVEGCNAHARSRGVCGRHRLDNHQSAILDKVESLSDLVGLVDIGDCDSDLPFGNIISDIELADKDKEILDRVLAPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WPE0</accession>
    <name>A0A6G0WPE0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Adhesin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_013017</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000166">
        <property type="protein sequence ID" value="KAF0729268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WPE0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014987"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.120">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39200:SF1">
        <property type="entry name" value="AUTO-TRANSPORTER ADHESIN HEAD GIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39200">
        <property type="entry name" value="HYPOTHETICAL EXPORTED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0729268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="36214" checksum="39F8AC4B9640C915" modified="2020-08-12" version="1">MWSFSNLLPSMTECSTLTETTHFLRTFVAKSKITSLAVHLGAVYITADASITHATACLRYDSPDLLDAFHISEGRHEWTLGWTYGKRAKGRYMIELRLPPRMLECVSFTAPGVMSISSGVVASSPSVHLSIHSSGPGQLIIQENQLVARGLTLWHTGSGSVQLISPISVDVVDITSRGRGIVAVVASTLTTSDFSIANHSYGTIYLKAPTHVFADDVRVVNDSHGAVNVAFDSLTTDQLTLVVGSSGPIFMSIAADLSVAMIDTRMSSSGSLQLTCSEDGSTCDRHQIAMSGSGDLCTNVSAVSTQTNVSGSGCVRDIAPCTLQSFDRIKSLPLRRLLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WQ99</accession>
    <name>A0A6G0WQ99_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta-lactamase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_012868</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000163">
        <property type="protein sequence ID" value="KAF0729602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WQ99"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011784"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050491">
        <property type="entry name" value="AmpC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825:SF9">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825">
        <property type="entry name" value="D-ALANYL-D-ALANINE-CARBOXYPEPTIDASE/ENDOPEPTIDASE AMPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026039540" description="Beta-lactamase-related domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-related" evidence="2">
        <location>
            <begin position="70"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0729602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="564" mass="63287" checksum="BDBF13C4876625BD" modified="2020-08-12" version="1">MLNSRLLVVVLLIACCFSTVDALKTNIVCKVSQFPEEPSSPSSHESCSCELTTSPSSLSMEDKKAIAIEFVQKHMKAWGIPGMALSVVVQNETVLSTGFGVKEFGDPERVVKSDSIFPIEALTELFIALAVAKLTESGQVHFKDTVKKHLPWFQLQDKYAEEHTTIQDLLVHNSVFSIFAELPFELGVFKSELEYVQALRHLTTYREFRDGHHQSSMNYIVLGQVIEAITKKSWFQYLKEAILDPLGMSNTYGRPADVTSKDKLTAGHFICNGRTIGPFSYLTSTTVELSPSNIYAAAFSMVSSIDDMTKLSQALLHKDKRLFQNGNTLRDMLADHTIKFGSLHKWLAVYGFLNVSESTPVVAGLGFDTIGNLLDNQPYFGKLGGYYGTAGWLPMQEIGIVLLVNGFNIPGRYIDKHRFQAVRSYLLRLFMGVPVERLNRDYQVWVEWAYANFTVFPCNSDYFGGIPWDRPGIEIAESMKKALVGTYCATESSGYIGNATIARAGQDLTLHYGAYTRRLIPTEHEDSFVWSLTRRARTYFVDVWIVDDQVSISLMLIQFDKCDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WQB8</accession>
    <name>A0A6G0WQB8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_012834</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000163">
        <property type="protein sequence ID" value="KAF0729566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WQB8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011796"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="7">
        <location>
            <begin position="2"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0729566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="276" mass="30715" checksum="4CEB5ABCFF498625" modified="2020-08-12" version="1">MAIGTYRLKGDDAERVVYDAICMGYRHIDTAAVYRNEDAVGRAIQRVLAKQVVARRELFVTTKVSPKQMGYDKTVAAVKESLAKLSLDYIDLMLLHWPGTQGKNAESPINLTNRIGSMRALTEAFSAGTLRAIGVSNFTTYHFQGLDEFPIHVNQVEFHPLQWTPTMHDLTNYCKARGITMAAYSSLGEGALLNAEAYPELQTIANELSCTTAQVLLAWGMHHEWIVMPKASAKERILENWNANNVVLSEDAVRAINSIVERTGPIKFCWDPSVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WQL4</accession>
    <name>A0A6G0WQL4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_012737</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000162">
        <property type="protein sequence ID" value="KAF0729676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WQL4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004931"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="587"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="305"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="596"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0729676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="734" mass="82383" checksum="6E100C68ED22415A" modified="2020-08-12" version="1">MTSNPRRAIAGPSPLELYIPRSLVTEQSIVTQTQHVRPTLNLQLEQGHSTQLLTNVQVQHDTVDIVPTHASLGIRPTMRSNDQVNAYDPVLLTHDQSMNAQRFLPSSAPSQTTDPSSNHELVPSDVEMENETPETALTLITNFSVQLQSLQTQVDSSSVMFNSLNDRLNLALQTSQSQHEMAATSKNSLSISLHELSDRTHQVQLEMNSTYGELKSALTDLQHSNRSLTHETDFVRLETLLAGQQTTISNLHQSLQQHSAEQQRISQNLETLANDRASDFHRILHELQVLSRSCEETQSPTQQKLDRSELRQVELIESNRRLNEQVDALTQDNSTLLQRVLTLEVACQRLNHEIHAVSKSESDSPVPTNGFDSPKSAPDSTHRLLLELQSSINAMASEMSEVKESIADSTSNQALGRAVKYTKTPTSDDQAHCEFFMKQLIDQADRCQLDDPDRKMLLGLKLSSDKVHPALNQWWIALSKTKNGDVWSEIYDNFMDRFCNRTPRELVDNLFEDSERLKGESVKVYAIRLQSILDDIDVPDHQGVVIFKRGVRHARAESCLENTDKDLCSIADMKLLRTRQIRLDDPPVYRERMRSRSGSASTTFTSSRSNLSDRSAPSTPEQSPRPNRRNSKVGFREDPTLAKILEAIHTTQTSQQAFVAQIQQLTEALTKPATPFFAAPVQAQMNVPYAYPSPYAPGCQQQPTPPVLIPSQSLPRLSLLDPLDRDLVPTLPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WQR1</accession>
    <name>A0A6G0WQR1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_012669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000161">
        <property type="protein sequence ID" value="KAF0729778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WQR1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018780"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033781">
        <property type="term" value="F:cholesterol 24-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006707">
        <property type="term" value="P:cholesterol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039983">
        <property type="entry name" value="CYP46A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24293:SF0">
        <property type="entry name" value="CYP46A1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24293">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 46 SUBFAMILY A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0729778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="219" mass="24547" checksum="6A62E2029DF38220" modified="2020-08-12" version="1">MATTLYFEPSLMNLTILVAATAICFVFGRFLLQFLWLSHQVRHIPSPKPSSFLLGHVLDTLGRAAKWQLAGDYPEPYISWTKQFGNAILCREIFNYVVIFTDLKAVQHVLATNGRNYPRNKVLESFLSDMVLGHGLLDSDGAEHDRYRKMLNPLFTPSQIKSFVSIYVSQTRYACDSILSQAASTGQVVNLAHVFSDVTLRIIGLAGFGFNFEADPEAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WR02</accession>
    <name>A0A6G0WR02_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Myb/SANT-like DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_012624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000160">
        <property type="protein sequence ID" value="KAF0729841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WR02"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007773"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044822">
        <property type="entry name" value="Myb_DNA-bind_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13837">
        <property type="entry name" value="Myb_DNA-bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="1">
        <location>
            <begin position="5"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0729841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="248" mass="28554" checksum="76EE417119BD948D" modified="2020-08-12" version="1">MVLEKWSDEETSKLIAYWQEHMEEYKKQKMPFYQAAAASIGTKGWKSIKNRCEHLDRKYAKIKQRMSASGFGVRSADPPTLRATITKEFKWYYDLDELLGVSSHVNPLAVLDTSQLSITDTSSISETTMVYGDNLALDEEQSERSAELDSAEIAVTSQKNPLKRKKPESNGESNISSILYNLGEQGLEIERGRLELMQKQIEFEMATRREEMQQRQREFELTYQTAQAKYELDKLMLEAKIRKLGSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WR06</accession>
    <name>A0A6G0WR06_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_012612</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Folate-biopterin transporter (TC 2.A.71) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000160">
        <property type="protein sequence ID" value="KAF0729829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WR06"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019936"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039309">
        <property type="entry name" value="BT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585">
        <property type="entry name" value="FOLATE-BIOPTERIN TRANSPORTER 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585:SF5">
        <property type="entry name" value="RNA-BINDING S4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03092">
        <property type="entry name" value="BT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0729829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="174" mass="19871" checksum="961B3E9FEC171AFF" modified="2020-08-12" version="1">MKVPQARSSQVWLIRNRDVLPPSISTSPSNDEQWAQERQKYTDVGALRDGEPLELYSWEAMGLLSQYAGVGIMMGFFDVLAWPIFQNYLHMEGYQIASYSALINIGWSSKTFFSVLADCFPIRGYHRRPYMVLGWIICAVSCLIVATTKFPAPYYSSQELFDMPRGQYTRADIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WRK2</accession>
    <name>A0A6G0WRK2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_012434</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000157">
        <property type="protein sequence ID" value="KAF0730036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WRK2"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF25">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026200742" description="AB hydrolase-1 domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="70"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0730036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="447" mass="48478" checksum="B4C9FD4D4DB374F2" modified="2020-08-12" version="1">MALRAFLVVIVGVVAANAGGIQWQVCPHSADPLMECGRLAVPLDHLDPSNPATIEIALQRYRTTLPSKGTILVNPGGPGSSGLSLARPEFLVLTGGEYDILGFDPRGVGASQAALCTQTVYTGIQDARSLKAKPVPFEEPGGETSIDRYAVDYALQVKRCERFDGKLLKYLSTSYVARDMDAIRAALGEQVLHYYGISYGTFLGLTYVNMFPDRVGRIVIDSALDPQLYLGPTPALMSKSATAQDAVFEGFCKACEAAGAQFCPLATESLSVSQRLRSFFKQVAAMPLILSAGDDWTSISSQEIRQQVFDSMEAPSRWPQLADLLQSYLNGTATSPARPASCQAEATTLYSGEDVEWGIYVANDGDNSATTAQDWEDHLKLIQMISPLFGGAWFVQALFAKFWTIRPVERYVGPWNNTLRSRILILNNEKDPETQLEGAQAVAAALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WRK8</accession>
    <name>A0A6G0WRK8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ketoreductase (KR) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_012441</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000157">
        <property type="protein sequence ID" value="KAF0730043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WRK8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004848"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF282">
        <property type="entry name" value="WW DOMAIN-CONTAINING OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0730043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="128" mass="13583" checksum="92AFFC70567E163B" modified="2020-08-12" version="1">MTFSIADIPDQTGRVVIVTGGTAGIGLESVIALARKGAHVIFTARNESRGQETLDKIKAALAPAPYNVEFAVADNTDLKSVEAFANSFLARNLPLHILLLNAGVAMKPYGVIEGVESTLFNNHVAHQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WS96</accession>
    <name>A0A6G0WS96_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_012300</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000155">
        <property type="protein sequence ID" value="KAF0730300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WS96"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005445"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045129">
        <property type="entry name" value="RNF123/RKP/RSPRY1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13363:SF5">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13363">
        <property type="entry name" value="RING FINGER AND SRY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="5">
        <location>
            <begin position="19"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0730300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="272" mass="29968" checksum="30601AB84B2E1AFD" modified="2020-08-12" version="1">MNKWAEEDLRAQRKRDGIDERELPVEVTPSGIPGWHLNTPTWAEGSGKKATTRMKRKRKTTMCISWMQARARPKVRHNAGIQSKRDQVGYKYSRIPRWELAYSNATIEGHGTFGTATVFGCASHVGKGYYEVELLTDGVIQLGWADASFEADDEEGDAKWTNGVSATFGSKWVAGDIIGCCVDIDAGTIGFARNGVEMGVAFTDVRPSEKSESTYGGLFPAFSLEAKERIRINIGDHTFAFKTKNDDLAVLDVLVKKPDIMSSPSPVRSSPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WU14</accession>
    <name>A0A6G0WU14_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dynein heavy chain coiled coil stalk domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_011705</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000148">
        <property type="protein sequence ID" value="KAF0730942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009295"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703:SF36">
        <property type="entry name" value="DYNEIN HEAVY CHAIN, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain coiled coil stalk" evidence="3">
        <location>
            <begin position="940"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="438"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="664"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="947"/>
            <end position="1020"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0730942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="2430" mass="274411" checksum="483954EB4B231C23" modified="2020-08-12" version="1">MALSLNQLYGSSQDGKFAEPLIKYLASDNSICPLPTHNYTFKINETEELPPSLAAFMTHRQRTWIEMDGTLGADWMEHILGLATPISSSSLTSGSAHISLMDNESFVVPPNVNFIFETIDLSQASPTLILNSPVIYVNDAPPHLNLEYEAKSSSTKLQPLYKSYIMGTISRLRLQSSLPSLVSDLLQKHLIDSPLVDRLIEVQSHGSLYARLSPLHSCQNVIALMQSFLTGRSGIKHDLLTNETTSNSNEEPLKRVKLQLELAVVWSLCWGMGSTASEQTKCILSSVIQKEFSHLHETWHSCSSDLGLFSMVLDLSIPCFRDCKTVLCGPSPNREITPFSIYVPRVDSTLVQLTSKQVLRAGVPLLVFGPSDAGSTSCLVDFLQRTSVFTSEGLTTLEKKSESPQKSTEASRITNIRLTTTMIISSLAGKLKLKRQEKKVGNSASNMRNLTDKLPSSARMSDPDTEHTISLFESGAFLSTFVRFNESSTIANICETLERVFQRERKRVFEPPTGKAMVLILDDMHLPFRNQYPSVHAWTRALLDLSLVYTEKDTRGKSLETTLYATAMIAAKMMDQKLIHFEAQVDQNAAKIGWKEALKQVVITAGVLEIDVTFIVQNVNIMPNILLEQLSLLLHDREVPLIFSPEEQCDMALNVKQEKMHELRVSHQTQLDKLRREISSEKNARLKEQHESVRQAINGSKELNNKTAKERELEAMLALEKEMDRFYQQKVDALLSVQQSEVDDLTRRFEATVDIQSSLTMAVIKPSGVLSGIWNGIMRSVSRNTRIIVCCESGDIGSLVQRVPKLLTKCQICSAPALTLDTIQILFHHQIGMIWKRFMEQEEQLKSSVLLNSYSMIEANLDKISSLAASLHLIALQVSQSCSKGNVVISLHQVPRYVQCIFDAMKRLQIHINQLLSQSRSFLDLYYMAVEKVDTAQKKQQEKILHIQNTSAHIDELKIHLEKTQEEADLIRDNMKQYKADVDDQVKITNDMDKATKHELKDALKILDDANRSVANLDRRYIMEIKTFVNPPVLVHVVLNAMCVLFSVEPSWENAKRLLSDVNFISSMLNYDKDNIPEHTLTKLEPYLTNEMFNKTEVEKQSIAASTMVVWIIAIDSYSRSRKLVKPKLDNLEAAQLKLRGLVAKFSECKKNMEKAEKVSSDIEESIQARIEEKKQLEIECQSLEKYLGEGNGMLKILEPEEREFAEYLNSMIEYEATILAEAVISAAMKTYAVSEQLLRIHSTCSILNGYTSQSFGIWLKAAGMFHSQHNQTTAYILAYAQPVVMITSFSSHVEAMILNVFHVIGCNSVVVKQAHDKDIRSVVESCMTMGQQLIINDLTPSLFKTVFHDLVEWETKWIDGLEHVIYQDRTIQLKRGFRLVLTSPHSLHEFGSKTFRTFIIDGSLCWDDMENVLLDDIELSSLFNDKTKLGAYDHSRQILDMEIDSDRAFDGLLTHMRSMILESSYDATMLDTLSTMCQQNARNRAMLDESRQMLNRVLEKSAPIYSSYARIGSVVFSALTSLNTQTPNNHTFEAYGFRMLFIQCLESSLNDARVKPTGDRICTPGDLLAKLLDVLSLSVPQDQWTTFLLLLAIEIRSEWKEDSKSVNVSDDANQQIAFQICKAYMPTSVQSIVTADTIQKLQKCTPEQLYAAFTSHRRDESIVKRNKTTQPPISAVQASQDEAVTSTLSSLSAASCCVLIMLTCSISVFEAFCEILYSNKFGLDLKTSASRGRSNSKEWFKILQNMPDHWFWCIASNHLATSFELLHLVLETIVPRQSWPDILSILLQRPDVRALPFEVPHEDENSVIAFFKNIQTMTHFEGSNPVIFQGLRWLIVTMDSTDKWDSILQYSKKYRIDYRPVGVISHLKLATSKPKHHRHVADEDVPATRLVHIVQTKASKIPYPVPLGDCIKKSEITHVPMNVQPNRLVLYPMGSSRFSFYFRRTTLRLVSMPFSSTIGDCLKHARLDATSMKIISIVTWRLICGLIFLHSSLLTRQCVVVGCAVDFVEFDMGDLLMGVHAITGSILHFIVEAFSTVQEGDPLDLLDWVAVQDAFMKYAYLRKCISKRGEWIIRNMLMECVGPYLFIPNSSPIQSRFRLPLPAFQEVLKTPTQSTGDYLNVLCSFSTTCNWSPPDVAQNEPTILFDPRLFVLKQKPMKNNAKAHLAAIISTCLNEIPAPLTLKGNPRSGGSQHPLRNFLKTIVQEFVVHRDEAISVFTKLLEELDDVDDRLDQIPNERLHNDLLAILKDEIPPSLKSISQPVVMNMTLSKSIEFLKLRAKHLQLWWNENQSEYLCPAIFYMEDFIRSFLLSCSISSNIPLDRLSAIGQVYPLNASIEPFRNRSDSILLTGLELLNAKPTEKHSLECAPGEIAPVNVLLRAVEDNKEETMDCPILPSRLNCTSAGAIKLKIVPSLQNWVCCPLLVMVPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WUD4</accession>
    <name>A0A6G0WUD4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_011613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000147">
        <property type="protein sequence ID" value="KAF0731065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WUD4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019596"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0731065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="664" mass="73531" checksum="263977CD40686725" modified="2020-08-12" version="1">MMTRSSSDGPRTRRSTTLQRVNLTRACSTDRDTQLRRTATPKSVGNHVNKENRLTRHNNAVTPFDARKQSPNRRKAVSEPVVPKERSIVHKDTSSSVQRQEQTESNNRPSRTRNKLSASAKSPALEALVSVSKRHRTSANSKRQVKLQDKTSNQDDGTTCTVPQHENERNAEKASVHGKLVEKVDTLEAVAILSSLKAVAASNAIDSSTTAVESTDMTAILPQVDDPAKLKSITSRDKRNKATTAAIYNIPRKNLQDKSESPKSVSMAPQEDEKPIVPPRALQRLLEIDMILTPTLSRRGGSAPDGSDVFTGVYIDAKNDEDEWCEAVAMQVDPSSAMVLLHFVDGPTTQTTWQHVRRVAGFHHFSKPTTDVKLDPERPKWDGFASLMRDFSRHLKRGVAPSPETKCQAIPRRKRTLSDAQHTPLGREGNKPLKLAQPKTKALKSDVQTTKKRQGKEEVEPQNNQQSKLQRPRPTASKTIHTSHSLDANGVNGAIMLGKRKRVKSKRAMDAMLHGNVESTAHIAIKMEPPSENAMNFKQAMKIDGHPRKRLKGHATIAKAEPSSKRKSLAFKIPVALIDRSSTRPSMPLSQLDSESSSASSRLFGVKPLLSALPTFAPAVMSPESREALRRHYLTHLHQSAHLLRTGIDEFAQRRCQEGTPLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WVI1</accession>
    <name>A0A6G0WVI1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_011150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000141">
        <property type="protein sequence ID" value="KAF0731525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WVI1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014044"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0731525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="188" mass="21827" checksum="7373279EDF4378B7" modified="2020-08-12" version="1">MDRMRKGVRRRHDPDDDEIRLEMPPNKKVLVELLENLCISMSTKDSVTIDEREENDTAAKFILSNGPRQYVYPQRNLYNLYTVYMRRMWDAPTAPPRDPSMGTMVLYNASPRVPSPLRCLMFPPFTIPEEDEGDGSAYDTDMMMDVDMDCEEYYTPPCQPRLAGSLTHSEWFLPDDPEDDGMDIMDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WWY9</accession>
    <name>A0A6G0WWY9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_010704</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000137">
        <property type="protein sequence ID" value="KAF0732051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WWY9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015188"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF91">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PLK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="4"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0732051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="300" mass="34119" checksum="62239E8E4EFEFB53" modified="2020-08-12" version="1">MNKYQVHPETEPALFGNVLLATDPRTNSKVAIKRVPVDSADNNSPITMERRVNKHVMKLGGHANIVPLRDSFQEDGYDHLVIDYSVKGTLFDVLKATPEKRFSNRESIEYFNQIVEGVAFIRKLGYAHCDLSLETVLVTNNNTCQLTEFGLASDASHKKYNPVGKYFYMAPEMYENRGYDPAVADIWSLGILLFIMLTGVAPFRQARVLDDQFELFKQRGLEALCDQLGVVDLIPNDAFELLDAMLKINPNSRITIKDIVAACDRPEMVVVPRRKNSFFNKVFDPIKAPFRHNKQQRSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WX03</accession>
    <name>A0A6G0WX03_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_010683</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000137">
        <property type="protein sequence ID" value="KAF0732030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WX03"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006342"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="338"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="151"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="398"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0732030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="407" mass="45805" checksum="ACDEE48DA9C9759F" modified="2020-08-12" version="1">MKQEITELQQKAQVIGYDRRLASIEIPNLTAAIQEKLQIHQVALSRLRWRQLQNLRQMEWEAKFRMRSKEMKKQAEGDLSSVQEAAMVIRLKEKVEHKQEANQIRVKHLQDLKVYKGSPYSDDGLLGVLRHVGINEADQVLLRWHDQFEHAQQLEAEQRDGEQRVAECRRQLDELRQEFQNLKLGQTTVKPGKLLATSKSANDLAATDGPKLHNFKHVEQQLTDATAVSQQKKQRAQRLKTLSENLHVGLLHLALLLGVKASQGMDSTMLVEAVEQSVRSLIGEEGGSATPANLTLRKKNSMRKGMAQGNASVQRSIEEKLKYNLRVRKCASPKKRLPYFDGNGGCTDDDEAGDSFSDSDDSDNSGGEEDVRARADIKASSVMEVQTHSGDKHADRKPGKKKKHADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WXD9</accession>
    <name>A0A6G0WXD9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tyrosine specific protein phosphatases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_010648</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000136">
        <property type="protein sequence ID" value="KAF0732202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019925"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016316">
        <property type="term" value="F:phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039034">
        <property type="entry name" value="INPP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12187">
        <property type="entry name" value="AGAP000124-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12187:SF11">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3,4-BISPHOSPHATE 4-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026120934" description="Tyrosine specific protein phosphatases domain-containing protein" evidence="4">
        <location>
            <begin position="24"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="345"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="527"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="566"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="606"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0732202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1295" mass="144124" checksum="419FFCA6295AED04" modified="2020-08-12" version="1">MTLEACLRAVLVVFGLFIAMTSALAPSIPFTAPICRYSTQPCTRQVDRNMSEIIAPASLPMQYIEYSSRLEGGACPTNFSKCVASTAYVPMLSRLPNDSVNLTFYYLKSDIPRDQVDRHLVFNLSSSVFLSGPTCSGTCNDTTWTTIPKDDSPISFLLTNASGLMDVLVASRYSSLIRLSSMDLKGADVVAPSNQGFAPTVSFESEPVRMRLSMFLPPVLSNLTVCFALNEPTCSDQTPHWSFDSLYSNASFDQIQGTISVGINMTNMSTSSFCMILSWDARLAAQSQQIGLAISGVSISSNSSTPVVLPEFMQWTASGTDAQCVPVTSLASPRSKNSNMVPKTLWTVISLVLYIFAFVIACLLVRLHGLTFVRETMYTDLALLSIICLLLCSVLLHILWLTILNRLPGTAIETGFLVAILDGLRQSIMWTLLASICIQWFAVVHPQWRTCHHGKLLLIWVMGVLVYLVLLLLYVVQNYGLLKCTYVDYVRNYRGGDRDLWLPVIQPGDWKFAVDKVCFDYGSRAGFVYTFGCLHCLPLGLLVLLLIFGTRLVSRGLRGLDSHHSVVQWAMCSLGFVVVTTVVVLVTQQGMTMYLYAKEKRVAPLVWLVVGEYLPTLVPSLGFLLLQWNSKLFALPARHLRATSSLAPPPPLLSTWNKPFVPDTALMSQRSLMSQRTAELTVAIRQGSTLANMVVEIHQAGNCEGTDTWKPVATISSEDKMATIKIYWQPLVQLRCTISVQPHRASLSATDYFTSMEELLQGPQEYLTSSGAVVVLSVALSSSISKTLSVASDVEITEHLRESQWPTDVALAYLKHLSLVRKSMYNSAVADIDAFEAAQQNKMNYANIIDQIQGESDVDLVRRWLHQRSTKRLEYHNMLQKCLELYKDRRRQGVFLKKSTEKVDSLLRFLPVNFHFHDMQVNAAEYSTITLGTFACHNLSKSHAPLLDDDEVDSGDRQALKPSSFADERVRYRDEVEWSTIIRQDECNGQALSTLAASVVDRVEAAIRSSALDQVWSGWAETTYLFQVESLLSDHGKESRMLEECAGATYWLASSTLGLSFQDPSSCRHPLSGVVRVELTANDSKNDSTPCGFHIVLYLCCAHAFDAASCVKVTPLLFSQGINEMQTLANKATMYKETLPDAINDVNGRRLEKYIGRRQDWPHMEDIQGKLGQLQDSILTSRRERVKKKHPEILQYAGQITRLLGGARVTCCKSGKDRTAMSVTLEHGWILSHFHHMNAPAVRRAVSIMRSEGVRLDCVDKNIGKRQYAFNALQRSMLPEAYRCPEGTYGNGNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WXQ1</accession>
    <name>A0A6G0WXQ1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_010644</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000135">
        <property type="protein sequence ID" value="KAF0732359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WXQ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013502"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013503"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF440">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="410"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="93"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="160"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="683"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0732359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1226" mass="140124" checksum="9710EBDA19912E9C" modified="2020-08-12" version="1">MVREDKTPAEMWQTLIDNYEKKEWSNTIYVLRRLCELKYDTNESETVEWILVTLPNDGPDNFNAFINHLKPTPNQEIGLKTLISALLNEEEKRKERKRSRSYHHSRERDHKKPKENRSSYANITHEINALTTKLSTIKNVRKSDGKWCFICRKTSDHVAQDHDDFDPNFRDKEGKGARPKDYSTSKASFTKTPLRKPLAGSNDDEVNYKINAVSDGTQNGHETHWTLDNCATGHVTGLRHYVVDCDGNANLILQNGQQIKGCSGTAHVQLMDGKRSSTLTLDNVAFEPNIYKNLISHIQLLTMGYRLVKQDLEEAIYVRKDEPRTLVFKLLNGMYVLQQTKSNQVNAVKTDDKLMRWHNKLNHAGFDQVAKIIKPIMNHDEDSTTSQHKCEGCMQGQAKRVSYRNQNHFVAPKPLESLSADLCGPITPKTIHGQKYTSVFTDHASRFIFARLLKSKDEAVLHLDELTSELDNQRRDSRISNIYSDGGGEYTKVYQRAPPPEENHLAEKTNEYLFNKVRVYMTMSGLPAQLWGYALDHVVYVYNNTPQELLNQRTPYEVLFAKPSRLHMLKTFRCLAYMYVPKSERASKLSNPAVPCVFVGYAKDKLGYLLYNPKKRTIQTSRSVKFDETKLRNANMFLDQDFKAGCLVIPSHDSTGKLALDDEIYKARFTTDQEEAPILESTDKFDGDSAAPNTQSGKRVATRKSARTIKKPKIYEVNSVSNKIVEPQTFRDVDKSEYRRDWIEATNTEYQAMLHNSVWELVPLPADRKALKCKWVWKAKYDADGSLERFKARLCPKGYLQIAGVDFTDTYAPVLRLDSLRLLCALVATLDLETAQLDVKTAFLNGDLDEDIYMEQPERYQVEGKTHLVCKLNKSIYGLKQAPRQWNKKLNDHLASIGFKRCNKEQSIYVMVNNEARSITYLAVYVDDIVIGTRCKKALDAVRGDLTRTFEMSDKGELNYLLGMRIERDRSAQLLVKYHMQGCDSEPTPQVQGLPADVRPNDNANNLPYRSLTGAFQYLVTATRPDIAYAVRFLSSHNHDYNTSHWRMAKRVLKYLQGTKHLGIKYDEGASARPKAFSDAVFANDKQDSKSITGSVITMGGGAITYMSKKQSLVGQSTTEVEYIAAAETAKNLIWLHELLHEMKVKIDLPIEMFVDNQSAIQVARAAATHSRTKHIRLRFHFLKELVAENVVCLQYTSTKDQIADIFTKVQTREMFEAHRARLCMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WXT3</accession>
    <name>A0A6G0WXT3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_010485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000134">
        <property type="protein sequence ID" value="KAF0732376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WXT3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001807"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026308431" evidence="2">
        <location>
            <begin position="20"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0732376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="195" mass="19941" checksum="CF316757999FF13A" modified="2020-08-12" version="1">MKVTAVVVSMTVAMSVVVADEDNGSATGSSSGSMASQSTDQVCSSSSEETIRTSLIAGVKPTTACAAVMPIQVTNISTAVAFLETLNSKDVLSKVCVPCGSLLERWAELPNCNATLVANHSSINVYDISFYFNDLCNTNVTSPPPITTSNRTFAPKTTTVAPTTSATPVPTSATAGALISIMSLALSAAAALIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WXU4</accession>
    <name>A0A6G0WXU4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_010612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000135">
        <property type="protein sequence ID" value="KAF0732323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WXU4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002008"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0732323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="339" mass="38554" checksum="A3AA302662D15990" modified="2020-08-12" version="1">MEPLKSQVTVIITTSAIPSNPSTAVLEEVLRSFSFVPDLNTCDVVLTSDGFAVKTKPGESKFKSIKITEQEAENYGEYIQRARAVFRKHLDFAETETVSSTSTTSTVPIGARATAESTVTRDSVVGKPTFSMITLSKRLGFALAVREALKLVSTPYILIHQHDWTYLHQLDFSVLCQLMDEHPEELQYIGFSTRKSLRRKCRPFLPRAVPREFGSVLLSPLYFWYDKPHLARASHYRTFLFGHGRFRVGDFIEDTMGQSMLADLKARGVAAHTAYGTWSYVRPDDPEKPTLRHRSGRHFRETVYMRTARHSKKNMTKAMENLSIDRKDDDEENDSSDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WYI6</accession>
    <name>A0A6G0WYI6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PSP1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_010356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000130">
        <property type="protein sequence ID" value="KAF0732648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WYI6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003528"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047767">
        <property type="entry name" value="PSP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007557">
        <property type="entry name" value="PSP1_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041131">
        <property type="entry name" value="RicT_YaaT_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830">
        <property type="entry name" value="PROTEIN PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830:SF3">
        <property type="entry name" value="PROTEIN PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04468">
        <property type="entry name" value="PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51411">
        <property type="entry name" value="PSP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP1 C-terminal" evidence="1">
        <location>
            <begin position="174"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0732648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="264" mass="30922" checksum="615779A6C02914EE" modified="2020-08-12" version="1">MQDDEDDPRWETDLSEANQLDGPYARLALDLAIRPRRESKLDTWKRRSNQDDDTCDIRSVEPVQAKAPSVFQPALAKQQSLPAMHRLFPTTFSLPHESMVSFYAAMDLEPLVDTCMYFEVEFKRCRRTIFMGHVVYTIGDYVKVEADRGHDVGRIARQVNYEELVSRSAHGPLKHILRKASHTELQLLACKMEEEAIVLDVCRLKVQQRALPMQVVDAEFQFDRHKLTFYFYADRRIDFRELVRDLFATYKTRIWLQHVVDPTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WZ34</accession>
    <name>A0A6G0WZ34_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_010183</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000128">
        <property type="protein sequence ID" value="KAF0732856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WZ34"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019614"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901">
        <property type="entry name" value="2-DEOXYGLUCOSE-6-PHOSPHATE PHOSPHATASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901:SF38">
        <property type="entry name" value="PSEUDOURIDINE-5'-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01135">
        <property type="entry name" value="C1.5.6:_HAD__Beta-PGM__Phospha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0732856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="220" mass="23791" checksum="6C6F7CF15952BB3D" modified="2020-08-12" version="1">MTIEAVLFDLDGTLIDMEMLSVETFIEVAGPGYTLDLHKRILGTPSHSWSRLIIDELKLDMTPEEMIHQCHVILGKKYASSVLLPGALNLVQSLAGQPVKVALATSSASSAVELKRAAHPALFEGFELIVCGDDPAVKRGKPNPDIFLVAAERLGIQDKSKCIVVEDSEHGVAAGKAAGMKVVAVPDTRFFTPVDIAERFGQADVILKSLDDWNSDTLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X0I7</accession>
    <name>A0A6G0X0I7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_009637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000122">
        <property type="protein sequence ID" value="KAF0733390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X0I7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009082"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0733390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="306" mass="34983" checksum="49398FF6E6A74EC6" modified="2020-08-12" version="1">MERPATPPTQFQHRDELIGYRSSYIPKPESRAGPQSYDVRCSFDRTPPPSIEIRRCIHLLYGRDFCRAQRKCKDEHVVALSPPPPQPSPHPAAQRKHVRSHSLTTLIPPGEALASPPGHMRSRSFSISDLNVSKLLLPEPEPEVKHKSKTSTKWKKLGEHLWHEKSKMLLNALLFTPPRHPYIERRNEVQNPLFHDHQCNSCQSSAVSNTTKTNFDSFIAGYFRNTSTQGSVHSQAKSPDTKTTQSKWAKWRQYPSDKRPQWTSNSPSRIDRKAAKRSSSTVTYSDFLAKTNSYTRRASLKARLHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X293</accession>
    <name>A0A6G0X293_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_009200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000118">
        <property type="protein sequence ID" value="KAF0734027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X293"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0734027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="352" mass="37924" checksum="B36B720D7FFFFA8F" modified="2020-08-12" version="1">MAVHCIVGFQILWITISCAYENAYLCDRDYFLALLSAFFLASTAALAFFLSSSYFLSAFFLSSSAFFLFSSAFFLSSSAFFLSSSAFFLPSSDFFLFSSAFFLPSSAFFLSSSAFFLPSSAFFLPSSAFFLSSSAFLSATFLASAADFSFILSALGFFLSAAFLALAAAVAFFLSSSAFFLSAAFLASAAAFSFFFSSRGLLLVLLGLLLIGGLLRLGGSLGLLLVLLGLLLIGGLLSLGSSLGLLLVFLSFLLICGNLGLLLLLGQLSRSGSDWLWSSGCCGGIRGRRGRARDETHAFHREPSTMDEDIVVRAGVGSDKRKQERDPEADSRHTLHVPKRNVKRRADCHARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X2B0</accession>
    <name>A0A6G0X2B0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_009482</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000119">
        <property type="protein sequence ID" value="KAF0733925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X2B0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004528"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051295">
        <property type="term" value="P:establishment of meiotic spindle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007051">
        <property type="term" value="P:spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051185">
        <property type="entry name" value="ASPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22706">
        <property type="entry name" value="ASSEMBLY FACTOR FOR SPINDLE MICROTUBULES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22706:SF1">
        <property type="entry name" value="ASSEMBLY FACTOR FOR SPINDLE MICROTUBULES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WW" evidence="7">
        <location>
            <begin position="739"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="688"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0733925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="770" mass="91915" checksum="44E24BF6118E6642" modified="2020-08-12" version="1">MLQSLFGTQPNAVKAKGKHLKRPRLQDDSRTAVERQWMQQEAPDHTFLRDHWRRRTMRMSIQAAKDVVLEDNVRWIKNNVPIKSLPKALISQHTKMTTLVDVLKRIFRTRLHAAFTRWSQVIESAKHAEAVTAFVQSEAVRSLQCIWERSWLRRRNRCFDLWRIDFVCSRAQEEVAAAAEIQRCARRYLRRDVLFHKRRHAAAVRIQSCYRRHAATLHFHRWLHEAKLDRAATHIQKSYRRKRARAAFLTTLVFYCQTEAAIVLQRWMRGSVFHLKWLRRRGAEVLAAEAATCIQRCIRAFLARQWFHRIRGYRSAQTIQRAWRRSRRRGHVRINAAMACLRREFDATMHDLGALVVQAVARGFLGRCRVRMLRKRLRCLLLLQATWRKYVVRQQQTKARHERRFKRIMAAHRIQAMFRGYQERRLFRMAISKSCVPMYLRASRIRFKEEQMRFRERFHEQIAWSAASVIETKWRQYVERREARRVKEMTAAEIIQRKFRSYRARRWFQAYAARVVKSAKSIQRMVRSRQERDRTKQYIAQMQRVVKEAQAVKMNQAARRVQAAWRRKHGQMAHHLRKMAQEEMNQHRVHSAKKIQAFVRRRRHLRQNKRNMAAAMANISQMVAARLNAAKKIQRNYRAYHAGRLGKAMLRSLKLSRRKKERRLARQRIIAEYLVEASAERSQETDLLAKTRANHEKIQAEKDRKEAEARAAKAERRRQALLAAEKNVRPVTILPSKKKASKTAWIEAWDGDGNKYFYNPETGESRWTIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X452</accession>
    <name>A0A6G0X452_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Bile salt export pump</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_008752</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000110">
        <property type="protein sequence ID" value="KAF0734596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X452"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018607"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000251">
        <property type="entry name" value="ABC transporter B family member 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000205">
        <property type="entry name" value="ABC transporter B family member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF27">
        <property type="entry name" value="ATP-DEPENDENT TRANSLOCASE ABCB1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="320"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="690"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="751"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="829"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="852"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="931"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="59"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="379"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="693"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1027"/>
            <end position="1270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0734596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1274" mass="138072" checksum="ABD2F87267A7BD1A" modified="2020-08-12" version="1">MAKSREDEYKTIATPRDDQAVQVEVTKPPTGASASNPAQEFSFKSMYRYADSTDKLLLVVGLLCSAANGAGFPLMAIIFGDSINAFVAPVNFDQVNKAALKFLMLAIGLFVAGYGSYACFAITAERQMKKVRTECLKRIMYQDMGWYDQREASELASRISGDTVKIKDGMGDKLGEALRYFCQFLSGFIIGFSRGWNLSLVMACVLPLMSVSVGILMKRVQAGAVCSQKVYAGAGAIAEETIGAMRTVASLNGESRAVKQYSQVIEQAEKEAIAVSKFVALAFGWVFFLIWFTYAIGLWYGGWLVSKQHNTVSDPGTVLSAFYGILIGTMAVGQISPNLGAVAAANGAAVALFKILDSKSDIDASDMSGEIPPTCEGNIEARDVHFTYPSRPEDPILRGYSLTIKKGETVAFVGASGSGKSTLVALLERFYQPTSGAIYLDGRDISTLQLKWLRSQIGLVSQEPVLFATTIFENIAAGGDNISRDQVIAAAKLANAHDFIMGLPDGYDTMCGEKGATLSGGQKQRVAIARALVRQPKILVLDEATSALDNESERVVQDAINNLMAHTDMTTIVIAHRLSTIRNADQIAVISKGVVAELGRHDDLMRLENGFYRSLVEVQSSAPVKEDAGYGVDGSAMQAYTQLDTESATATSKVLRSSDSHLNISTEFADAVEKEVKFGRIFELTKPQRVYFILGLLASCVQGFSMPGISLIISKVINDMNTHYAEYLESGKKDMAPMTALYDNVAHSAHIFIGVAVAILFTAFIQAYSFRIIAEKLTTRLRKMHFEAFMRQDIGFFDLPGHTTGALTTDLATHATKVALVAGESQARILQALFTIVAGLLVAFFWGSWKLALVMSAVFPLLLVGSYARFMQFKGPNYADNLADSGSLATEAITNARTVTAFGLQDHILARYEALLEKPLRAGTKQGQLSGLLNGFSNFSMFAVYALVYWYGAHLMNKGDITFKQLINTLMAIMLASQGVGQIAGFMGDTDAAKKSAAKIFSILDRRPPVDSSSSDGLKPVNVSGRIEFNDVFFNYPSRPNVKVLQHYDLTIEPGQTVAFSGPSGGGKSTCVALLERFYNPTSGSITLDGRDISTLNLHWLRSQIGLVSQEPVLFVGTIAENIASGLSDYTSLPDLQERVEAAAKMANAHNFIMQFPDGYQTQVGLKGEQLSGGQKQRIAIARAIMKNPSILLLDEATSALDSESEKVVQEALDKLLAAKGRTTIVIAHRLSTIRHADKICVVSGGRIAEQGTHDQLMKHNGIYTHLVETSTHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X5U2</accession>
    <name>A0A6G0X5U2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">cGMP-dependent protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">Ae201684_008204</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.12" evidence="4"/>
    <dbReference type="EMBL" id="VJMJ01000100">
        <property type="protein sequence ID" value="KAF0735289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X5U2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012352"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030553">
        <property type="term" value="F:cGMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004692">
        <property type="term" value="F:cGMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000068">
        <property type="entry name" value="cGMP-dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002374">
        <property type="entry name" value="cGMP_dep_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF37">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000559">
        <property type="entry name" value="cGMP-dep_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00103">
        <property type="entry name" value="CAMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 19 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0140">cGMP</keyword>
    <keyword evidence="14" id="KW-0142">cGMP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 19 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="23">
        <location>
            <begin position="87"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="23">
        <location>
            <begin position="205"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="23">
        <location>
            <begin position="330"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="466"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="24">
        <location>
            <begin position="740"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="18">
        <location>
            <position position="598"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19 20">
        <location>
            <position position="495"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000559-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR000559-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KAF0735289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="790" mass="87847" checksum="5B42800FF409EC5C" modified="2020-08-12" version="1">MASTTPSHAAPPPPAPAKILQDLSLDSPPITRPPSPTEASVRGAVNRRAPINDASVEPDSAGPSRATHPKSAETIQVILRALKAHYLFSSLGESEVQDIMHAMSSVEVAADANVIVQGEAGNCFYILEAGQCEIRVNDVVVGQYVGGDAFGELALLYNCPRAATIRTKSPCRLWTVDRTSFRKILATTASTMQLSRVQFLQNVDLLQRLSNNQLQKVAAALHLEQFDSGTYIIKQGEEGHTFYIVVEGTVRCTTSSTHDGSEKPLMTLTKGQYFGEMALMLNEPRQANCIADGTVSCYVLGRQDFTNLLGPLRSLLDRQMRIRVLRSVPLLNYLSDDELDILAHALRVVAYEDKQQILRQGDNGDTFFIISDGKVRVNKSGVEIMTLRSGEFFGERALLNNEPRAADCFAVGHVECLCLDRSSFEGLLGKLEHIMVRETKRQQAMQQLAATKIPVATAKKFRLTDLDKIQTIGTGTFGRVFMVKHKTTGQTFALKCMQKVNIVETHQQRNVLHEKSIIGECDHPFVLKLYETFTDADQLYMLLELVQGGELWSLLYEKAYLVPKGLCGAFDVPSARFYAANVVEVFRYLQTVGVAYRDLKPENLMLDSQGYLKMVDFGFAKHIPFYKGSQLCEKSFTLCGTPEYLAPELVLNKGHDKAVDYWALGCLIYELMSGRTPFQHQEQQRIFEKIIHARTALKFHSKFDPLAQDLVTKLLEPNPGLRLGSLAGGMKDVVNHPWFAKMDWNALVHKTLRAPHVPVIKSASDVSNFDKCSEAHAVAKYSGPDYFDGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X7A2</accession>
    <name>A0A6G0X7A2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_007901</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000093">
        <property type="protein sequence ID" value="KAF0735899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X7A2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005352"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.540">
        <property type="entry name" value="XPC-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015496">
        <property type="entry name" value="Ubiquilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015360">
        <property type="entry name" value="XPC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036353">
        <property type="entry name" value="XPC-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677:SF3">
        <property type="entry name" value="FI07626P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677">
        <property type="entry name" value="UBIQUILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09280">
        <property type="entry name" value="XPC-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101238">
        <property type="entry name" value="XPC-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="157"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="233"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="306"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="378"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="452"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="596"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="742"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="687"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1008"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="699"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1024"/>
            <end position="1038"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0735899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1264" mass="139713" checksum="28747C5407600FD4" modified="2020-08-12" version="1">MVQVPVTVRAAFMNLSDMYMVDIDESIDQFRNAMIREMQTTPAIFDQTMRLQFGSRVLRSGEWATLRSIGVDSGAVIDVVLGGDVGLNQFSSRSRNPFEFNANTAYDTADFLNTFNNIMQQAGQTNYSAPTPPAPLTSSNSFDSFNNTLQAQVNAPKTIIVRTFDGITKKVDTQLTDTVGAFKQRVAAVFGAHPSSQRLYHLGIEMTSDQQILQLYGVYAGATVHLVIQPMPFKVYIRTPDGRTERAEADPSETVAAFKTKVAPIVRLPALRMNLLFSGKRLEDQTTMGSHGMAAGATLNLVDLTVTLIVQTPSGRNSQVEIALNKTVLQLKQHLQSLWGMLPEQQSITLAGETLSDSATLEFCGVVHGSTLLVTEILTLSVLYMPSRRTVSVPCPASASVRYLKALLAQEVRLPVEKQQLSLNNQPLSDEMSLAQSGIVSNSANLKLVTGMTIFVSVPSGGTLALTVPADATVESLKQTLAEKVGVPVHEQRLACAGIGLHDGTLGSNGVRDGSDLQMRRRTLVPTLDDLRANPDFNKAKSKVQANSSTLHGVVDALVRQNLAMRDLIQGNQEQFVTMLTEPVELPRSNNEPWHARVNVYMLPSKRVAITADLNDSVLAFKIQVQAALGVTKANQQLCFGTHMLDQDDVTLASYGVKAAAMIQCIEVPAKTPIEDVLAQNLSNYFQPKQQPPKQQPVRKTESSPKAQEETQEPERTAKTLDELLELIQTGRRKEWPLLGNYFLCPDVIASSNHSIFRVLNKRQPLKQLAVKLSDCRREMDFFESINGIENANEHIVECVEWGELTLANYKCYATIMERGLNNCSDRRRFLRRDKFARYRCIEHVAHALRFLHSQRWIHGDIKLENVVYFGDEAGYKLIDLDHAIHIQTAMSAHCTHEYCPPEMASFILGHTRALAASEKFDIWCLGVLVLKLFVEGDVLHEFEGLSDDGILQLIASPDFALVESLDECSLELSQKRRLARCLHPDPARRGTLDDILAILPRTTTMRTAHPRVQQPSASHFRPPEPPAAKPQAPPAIPKPQVTPSSNQVKDVPLPCMWKLEGASDPLPRGDKLRSLSLRIVFSCEMRDGTPCEFDVDAQDTNLCLEAQSPALRLALSSLKTSFLVHKAMGLVTSYGISNGPHFNFEFRDGPLVQKVLVGLENIHGAVESTAPAGLEEFVEALDNGDLDDDEVSAKVPKLFAQIEEYRVNDATQLIKVLESLGFNYQRDVVGGLTKRVVKRGSSFEGQVRWVCKKHAQQFGSSFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X7P5</accession>
    <name>A0A6G0X7P5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_007684</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000091">
        <property type="protein sequence ID" value="KAF0735934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X7P5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018758"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0735934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="291" mass="33077" checksum="57AA9E20F69A1892" modified="2020-08-12" version="1">MKKVFLKKPRLMHQELHSEGWRAYRLAPTASLRRAAIHAIADRQLRRMDHAFLRTGLLDRTDDFTKAELKVEANGSVMYQLATHIKLSCPRHIISATLWGVVGGPQDAYLPWDVTEDFEQIDESTVYSRIVDARDPNKTWHSNVIRKQYHEQDKDILIARAVLDDALVPQMTTDGVENKWIWGQVASLDDSSCRLTLLIQVGLNEIANDSSTVQCAVDMANRMNRTLPSSLTVKEGNESEMPIVPASYDMDVALVEHPSIRFFLENGKRVRDAVNYALRQVIQARNGEPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X8A0</accession>
    <name>A0A6G0X8A0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_007667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000090">
        <property type="protein sequence ID" value="KAF0736081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X8A0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004828"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0736081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="443" mass="51017" checksum="C53B155B523BBC2E" modified="2020-08-12" version="1">MEDSWLQDLQFLIATDDQLQEELVHVCEILDEGATTAVPEDLTSSPASPVSSPVHHTVDNKNDILKETSKSVKGTSKERVKPQRSSVRQREEIRCLRQQVEQLTAVLKSQQTTDVTTYDMSLWERTAKQESAEKNKSLQENEYLKEAVCQHATFIEQMQRVFRKKPRLSTHIDIHSEEWQAYKLAAQTSLREAAIHAIADRQYQRMQSAMVKADVFEREKALFKVMAKPQPDDSYVLEIIHHADLDAPFRLLGSAAWNVFEGDLPLDLPVNAVQGYTHIDPYTVYATYMQERDGMACHSNMVRKYYVEPNREVIVSRTVLEDAALPHMTKGAIENRCMWLIVKPLPNDPNRSRFTLLQHLVWPKEQMTLQKDIIAEVLANLKKLCFEFKVTRPGLLPMTNEMDLSRLSFPNMAAFLERGCRFLDLLKAKLNSAIEQFQDQRLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X8D8</accession>
    <name>A0A6G0X8D8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_007269</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X8D8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011531"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14499">
        <property type="entry name" value="CDC14_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17657">
        <property type="entry name" value="CDC14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000006">
        <property type="entry name" value="Dual specificity protein phosphatase CDC14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044506">
        <property type="entry name" value="CDC14_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029260">
        <property type="entry name" value="DSPn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14671">
        <property type="entry name" value="DSPn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22785">
        <property type="entry name" value="Tc-R-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="5">
        <location>
            <begin position="211"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="6">
        <location>
            <begin position="291"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0736247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="422" mass="46568" checksum="35A2212E8F5F5AB6" modified="2020-08-12" version="1">MASESVPWSLNDSHDGGSLLLLNPTWNLITLDFGFVTLDMAPVVVEIVAGQLYYEPCSRPASRMDTTKTVYLNVEDEFVYTNYFDDFGPLHLGHTFQFCDMLSDALTAAKKAKQQLHVVSSIDIHHQTNMVCLLCCWAVLCNGQTPQRAIAPFEQLKLAPFHDATDEPCEFDLSVVDVVQGFYHSVTQAKYISRATFSATDYTYYEKVENGDLNWISPKFIAFAGPQDIPTPGATTHPPAFFVPYFLAHHVTLVIRLNDKLYDESPFVNAGISHVDLVFPDGATPTDTIIAQFLAACEATPGAVAVHCKAGLGRTGTCIACYMMKHDNFTANQAIGWLRLCRPGSVIGEQQDYLVAKQAAIRRAVVATTSPSSISRTKPRVTTRVATTATRKTATDRRAQGDRLLAAKRKHFDDAVHIAVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X9Z6</accession>
    <name>A0A6G0X9Z6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_006944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000087">
        <property type="protein sequence ID" value="KAF0736784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X9Z6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005284"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0736784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="25663" checksum="C3A1362EEEA5EC17" modified="2020-08-12" version="1">MLFVAPFVAQFCNGSLYAWSILNPHIDSYIQGRSMDAMPPPPNRTESGPPAQMNNSVPPDEKAVVAFYSAASFLGFAARLLVDQVVVLALLKSPIHDPNSFGLFQVVVFFLTFSYGGVIGIMPSLLTDMFGVYNSGTMHGIILTGWSICAIGGGLTFQHYFFKIKDSYPMEQMRDGEIAAYISNFHWLMVVACIGLALVPLVRTNPVDRFYPGYQYSIFGRPLIRFTKKDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XA56</accession>
    <name>A0A6G0XA56_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_006953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000087">
        <property type="protein sequence ID" value="KAF0736795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XA56"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013273"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF317">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0736795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="389" mass="43410" checksum="CDDBD2B37F62187B" modified="2020-08-12" version="1">MSRRHYRNGRNPNVSRCTSDPPAVENAVITFYISAGALGFAAAFFGPFVERHGPRHSLILALTLLFVGHVASFLSVHYHNYVGLHLGYGICCGAGFGISYITPVSALLRWYPDLRGTAGGFGVCGFGLGVALWGNMYQPLIDAVGIDWFFLIFGSILCFVLLLSSFVLRTPPPDYMVGGRDVHGVKVSLLPKQNSSKILGDSTGSNDRVSPVLGDERKGNYFTVFDYQEQELGEAEILYHNKIKSLRMRQCVFSIEYILLYLVFFGAVATGIIFMSRVYSIGQNIFLQEDDRSLTRLVMYLALCNFFGRMSCPILSDAFIQVGQLNPAFGRKVLIGLLMVVQVVALFYLESLIRSPNSFVSSRVVLPHLLLRRCHWRHPVAFDRHVRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XAI9</accession>
    <name>A0A6G0XAI9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_006901</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000085">
        <property type="protein sequence ID" value="KAF0737097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XAI9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021123"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026326515" evidence="2">
        <location>
            <begin position="19"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0737097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="159" mass="16569" checksum="D647CBA85E5A7A39" modified="2020-08-12" version="1">MQVASIALLFLSVKFAAASLVEPAPLATAKEDVPLVQAVSVGALLRPSSAPWPVVYAEPERALKMAAPKLKTRPRTSNGAGKAGRIGARPGRKGPRGKALRSASRKSGKGPRGKSGFGGKALRSRKSGIRRPKGLSAGKSLNRIKSRGLGKRPKRAAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XEE5</accession>
    <name>A0A6G0XEE5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable pectate lyase F</fullName>
            <ecNumber evidence="5">4.2.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_005739</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Pectinolytic enzyme consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins. Favors pectate, the anion, over pectin, the methyl ester.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Eliminative cleavage of (1-&gt;4)-alpha-D-galacturonan to give oligosaccharides with 4-deoxy-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.</text>
            <dbReference type="EC" id="4.2.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the polysaccharide lyase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.2" evidence="5"/>
    <dbReference type="EMBL" id="VJMJ01000075">
        <property type="protein sequence ID" value="KAF0738387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XEE5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007425"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004898">
        <property type="entry name" value="Pectate_lyase_PlyH/PlyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33407">
        <property type="entry name" value="PECTATE LYASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33407:SF9">
        <property type="entry name" value="PECTATE LYASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03211">
        <property type="entry name" value="Pectate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026253662" description="Probable pectate lyase F" evidence="12">
        <location>
            <begin position="23"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0738387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="259" mass="27332" checksum="DD99001B23E0E3C3" modified="2020-08-12" version="1">MVQIASFAALAALASLFDTTSAVASLPSGNWPTSLGNVKYSAPFVVKAGTVFDGQMKTYERSNAPCKGQAEGGKDLAVFLVEPGATLKNVIIGANQREGVHCETHDCTIENVWWDDVCEDALSIKGGSASSVTKVIGGGARNADDKIIQHNGAGTVSIEGFYAQDFGKLYRSCGSCKTQVQRKVTVTNVYAVNPKVTLVGVNKNYNDEAKFSNIKIKSSKTPKVCTYFQGGTSGEPKELGSGILSPTCQYSASDIHVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XFS1</accession>
    <name>A0A6G0XFS1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_005317</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000068">
        <property type="protein sequence ID" value="KAF0738948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XFS1"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0738948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="26620" checksum="97728C2223E0FD8B" modified="2020-08-12" version="1">MGWSCTSLISMLLRVLGFLFSIAALFIPEWSAMELRSAQFPSAAVAFAAGVWSFCIQARKTTSSVYDACFTYFGTSSDVVPLSNSTSTSSLVHSGACHSSTSFSNSIASLTLIAASDFDLYLHHVCGYWGQVTFALAVLVVVFGLMSILLSIRRGEHSTWSTIANISLCLAIISCVSSVASWLFVANGLSSSGVSIGVSLFLQVWAAMLYLASGIAVVASRHHTRQRRSDPSKDSNPIQSVTSPLQHVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XGR4</accession>
    <name>A0A6G0XGR4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_005018</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000064">
        <property type="protein sequence ID" value="KAF0739452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XGR4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014362"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0739452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="228" mass="25964" checksum="125426F4FA909827" modified="2020-08-12" version="1">MDGTTHDEPNPALTTCEVDGKLENAAVDKELESEARTRLVLADRAQQIHFLAYQLECDVADLGLWTEARIIPHSWRLGIQRHVAPLLQRLVAHMAKLVEIESYLLPPFKPQLLKQYEVQLQVTEEFALFLFDCIQECKDRAIKAEQTVAAIMIQSHYRRILHERGFYTTKITLTRLQRGLIPGLFDGLKTETTMKVSADRIVLEYPKALDTSRLVAGKNGARMHSSNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XH70</accession>
    <name>A0A6G0XH70_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Niemann-Pick C1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_004783</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000063">
        <property type="protein sequence ID" value="KAF0739607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XH70"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014279"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015918">
        <property type="term" value="P:sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032190">
        <property type="entry name" value="NPC1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727:SF2">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16414">
        <property type="entry name" value="NPC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026225569" description="Niemann-Pick C1 N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Niemann-Pick C1 N-terminal" evidence="3">
        <location>
            <begin position="68"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0739607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="353" mass="37982" checksum="2BCC2A2374C6A480" modified="2020-08-12" version="1">MMQRIWMIVSLVAGWTGLASGQGCAMTQDCLNPNNTPDFNDCIPKALEKIAPPQPMNGTGWANVTGGGACAADTDCHKGKCVKGACVCNNDGVTAGAHCDDVMIQCPEYKESACCSWQQNRALASNFQLISSFFGSDSGGCDACAANVMRLWCGLVCSPNQADFMQMHLPYPSINYRMDPMTGVDHVKVLEMNVNLSTPFTCGLFDSCKNTPLVSLTDALKSSVGFLNYQAQTGSIGHGQFIHLHFGRNDSFFNHSMLQCDNYSIVTDPREWTALPAQAKMLSSIANPLSPKQCPCAACRKTCNAPSNSSTHVTLVDKPISVWSGFDAPLVGIVYAGIAVFTAIIYSVAQRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XIR5</accession>
    <name>A0A6G0XIR5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_004405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000054">
        <property type="protein sequence ID" value="KAF0740172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XIR5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017109"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35763">
        <property type="entry name" value="COMPLEX 1 LYR-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35763:SF1">
        <property type="entry name" value="OS11G0133900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0740172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="114" mass="13359" checksum="3909CAF2CC8AF39E" modified="2020-08-12" version="1">MSVRLGSKTEVLKNLRTLLRLNRQSTSNKQWQNLILEKFRERQHETDRTKVKAYRAEATDLMHLWTGVSTQKTLWAMDAGIEKRMKNADIVKKSARLVGLQVPDMYTDKEENKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJ70</accession>
    <name>A0A6G0XJ70_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_004138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000052">
        <property type="protein sequence ID" value="KAF0740402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJ70"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005179"/>
    <dbReference type="OrthoDB" id="150814at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0740402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="174" mass="19817" checksum="B151E99DA17F7988" modified="2020-08-12" version="1">MHDYESAQAHFLYEHREPCSQIAVVQLVVFLVSFIFTYLTWWAGLFGLLVAAVGYYGTLTPVVQSKVSFIQFYYFGNCFILFLQVLSAIVLVVVVSEWPSITSWGWVVIVLGTVSYILQMYLTYVAIQRSYSYRAELMRSPPPAEIMVYSQQSVYTAVPQMVGSYRAPVDTKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XK00</accession>
    <name>A0A6G0XK00_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fluoride ion transporter CrcB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_004059</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Fluoride channel required for the rapid expulsion of cytoplasmic fluoride.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>fluoride(in) = fluoride(out)</text>
            <dbReference type="Rhea" id="RHEA:76159"/>
            <dbReference type="ChEBI" id="CHEBI:17051"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:76160"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000051">
        <property type="protein sequence ID" value="KAF0740513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XK00"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003421"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903425">
        <property type="term" value="F:fluoride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003691">
        <property type="entry name" value="FluC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259">
        <property type="entry name" value="FLUORIDE EXPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259:SF1">
        <property type="entry name" value="FLUORIDE EXPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02537">
        <property type="entry name" value="CRCB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0740513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="32313" checksum="3DDF9508401602DF" modified="2020-08-12" version="1">METSQAKPTLLTAMGLSFFLPNILGCFIMGLCQPLKARFKQYDEVWTGITTGFCGCCTTFATWELHTAYQYLSHLQVNATFVFCAQLVCCFGAHWTGVYVASEPLSPHADAQVLVKRLQTNITEEEECDKWQAVMDALDAVPAPRPTATPDQPVAVARSCLASFFISLVVVTACAIVHQPTWSSMWIGPFGALLRYDLGKRFNRSGHIPYGTLAANLLASTIDCFIVLYVNKPEWLGPAIMTGFCGSLSTVSSWVNELNTLSVPMAVKYGLLTHILALGLCLLVLGASQKIDSINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XK58</accession>
    <name>A0A6G0XK58_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">E3 ubiquitin-protein ligase CHFR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_003984</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CHFR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000048">
        <property type="protein sequence ID" value="KAF0740607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XK58"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009187"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052256">
        <property type="entry name" value="E3_ubiquitin-ligase_CHFR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16079:SF4">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16079">
        <property type="entry name" value="UBIQUITIN LIGASE PROTEIN CHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FHA" evidence="7">
        <location>
            <begin position="25"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="174"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0740607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="352" mass="40089" checksum="BAEE45954959E98A" modified="2020-08-12" version="1">MLENESPGPHQENEPHVLTFELASVCIGRSRDCELSLSSEISLSRVVSKKHARLYPCMFENNQEVRWFLKDLDSKHGTSVNGQDLKPDNSVQVFDGDNIVLARQHGDHFQIKCHLRGRGNSKLVLITYCPLNSKVRSSSSGEKRKSEPKDMAMKKKFRSLEADPRNHSESPLKCSICFEFFMDSLTLSCSHTFCGSCLRHWFLHSMTCPTCRVHVTDMPVRTRALDDLCAQLVDPKDTAWIARQEAFLSEQARLTKKARKIRHAFLETQSLPWPKVWTLWDDAGDNRQAFLQAVSTAIGVVREAWCEAIGLTESAIDAFPKAKLAIAARNLLEDVSDRTDLRHRLRMFLRYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XK81</accession>
    <name>A0A6G0XK81_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_003860</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000045">
        <property type="protein sequence ID" value="KAF0740728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XK81"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019042"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000610">
        <property type="entry name" value="Multidrug resistance-associated ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000997">
        <property type="entry name" value="Multidrug resistance-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="717"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="790"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="815"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="903"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="90"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="398"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="682"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="995"/>
            <end position="1229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0740728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1236" mass="136641" checksum="AD1CF8ECB74C5021" modified="2020-08-12" version="1">MLRSNQAKYSTFGAASEAVHPRDEASWFSRVFLTWCVPLVRIQRQLNIDDIWALKDINKVETNYKILAASFERTNSVFRAGMDAYGGAYLFTGLMGFLVRILDLVGPIVLQKVVDSTGDLNQMYIWLGGLLLAKVMRAIIWSHYVLYQETLGVRFMGGLKGLLFQKLLSKASYEQKDVPDLANAYSADMETLFWASISLNNLWILPTQVIVVSYMLYQQIGVSAFAGMGVIVLSLILGSIVATIQSKSYDNVSAARDQRMQAVKETFGSILVVKLQAWEAKCYEKIKKLRDIELGHIWRLLLGGVASIFILWATPLFVSMSSFAVYTMVMDQQLTATKVFSALALFRLLQNPVREIPDNISAVVQARVSLNRILSYLTQEDKPVRPEAPAPEDQNVLVTIQNGTFTWGDESTPILKDVNLTIHRGDLVVIHGKVGSGKSSLCMAICGEMKQTQGTSGVYGSIAYCSQEPWIQQMSVRDNILFGKPFDSAKYTRVVDACGLLPDFELMAFGDMTEVGSKGRNLSGGQKARVSLARACYSDADIVILDAPLAAIDAVVQKEIMTKCIESLLKSKTVILVTHNADIIGAESVNRLVELNDGIAIQTVANPSDNSIRGQSGTSEKPHTLSGSLYSPRHIEMQSKWHQHFEVAMAEETSEEDRAEGRVNGSVYSSYISASGGAWTVFWLCIIQTLWQGFQIASDVWLGQWTASSDAAERTNWYISIYSALCLASVVMVLFRTLVIASCGLKAARFLFENMTSSLLGTTLTFFDNNPIGRIINRYGEDTASIDTRLSFTFGSFVAVFFALSGALLTSAAAIKWASLLFLPIGYLYVRLSLMYLQPSRELSRLNNVTNSPVLSFLDEVEQGFMLLRAYGKTHLNQAIDRHAHHVDLNNQMWFARAVVNMWFELCIQIQGTAIVMIVATGLVLFRSTFSAGMVGLAFNYVLMADANIVDLVNIYSYIEIGMVSPERVLQYSNLENEEQTLAKKATFNLTQGSINFNHVQFRYKPTGELVLKDLTCSIQGGQKIGIVGRTGAGKSSLTMVLFHMYPIESGSISIDGRDISTIAKQELRQQLSIIPQSPVLFKGTLRQYLDPFGSFDDAALWSVVSKAGLHTLVSEMPDKLSTELADKGSNLSVGERQMLCLARALLVQSKIVVLDEATAAMDHETDVKLQRVIAEEFADATVLTIAHRLHTIMNSDRIMVMDAGCVVEMDSPANLLAQEDGVFYRLAKDGGVLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XKQ8</accession>
    <name>A0A6G0XKQ8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_003583</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000041">
        <property type="protein sequence ID" value="KAF0741011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XKQ8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018534"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00106">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000080">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF29">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3 4" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="6">
        <location>
            <begin position="1"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="407"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="57"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0741011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="525" mass="58633" checksum="868ED5291F99DBDC" modified="2020-08-12" version="1">MQVVSAGPGGRELVRSFMFDVCASEDVSQAEFFQLSGVATLLDSALEGYLATVFAYGQTGSGKTYSMSGLEEKLGVAKDHSKGEEQSDGLIPRSVRYLFQAINAKSNDTNFVMKASYCEIYNEQAYDLLNTASGPLNVRWNDRNGFYVQNLLVVQCDSLEDVMAVVDEGHRNRRVGSHEMNKDSSRSHSILTITLDQEVIDPSDGHAVMKYGKISFVDLAGSERLKDTKSTNTEETSSINKSLLTLGKVIAALGSKSGTPFVPYRDSKLTKLLMDSLGGNSLTVMIACVSPSPVFLEDTLSTLNYATRAKNIQNKPTIQMDPKESLIMGLRKENQVLRTENAYLKQQLQSTGRVIPNETLRSPSYTTEGMKPVNRIAPLSSRSPPPEQQFQQNAASMADVESFNGVMTAYQNQLIFLQQENAQLHANQGYSEHRLKQLMAENESLQELLVATKAQPESRHTNEAIDKLKAENVKLKMQLQHHREKNPTDFDILDQVRQMNLRVEQLQKREQELMMALARKNRSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XME7</accession>
    <name>A0A6G0XME7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_003270</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000036">
        <property type="protein sequence ID" value="KAF0741590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017719"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017875"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018009"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13456">
        <property type="entry name" value="RVT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="3">
        <location>
            <begin position="821"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="4">
        <location>
            <begin position="1148"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="142"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0741590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1551" mass="176082" checksum="72E79B0413B559A1" modified="2020-08-12" version="1">MVDTSRRELNLPEGEYVELHDQPVRYSRGNMNYVRLNRDVSIPPGGSVVVPLPKLREGMPETLEYWVHRDVRWITTALNSENKPAAYKVTNVSERNVFLSAHTVVGAISAQGERPLDRPMVRTSSLRYQAWKAEAWEGIAAESADDGSWKEPRPPSPRHLLTADGELRETCEVDDESSEGGRQPFADQTAVEPGMPPSLTEAAKSKTPAVFCYHACHFRDTLPPPSILLMDTVPDNLDQRRMAKEVVLREGIDLSTEELEQQLAIIPEVPREVEPFDPDQLDVGEDELSDDEKEKMRVVLRKYRKFFIKSGNGLPPPAKGAVCDIDFGEAKPLAERARRIRPELLKKLFDLLRGLLDFGLITFSNSPWASPIVLVLKKGGKDIRLCIDYRGINELQELMRSPIPTLDGMLANFHAMQWFLSLDNASGFWVVRATKRARKVSAFICALGHFEWTRMAQGLKNAPMIYQRMITNALFGFVDMPPGVADEDADGEPVDMFALGFKCDLSQLPPPANRTSFADDISDGADSWDGIVELTDRILARLTYFGVSISALKSKFGKIATDFLGHVVSRRGLEARPRSLDAVLAAPFPKCLRDMQSFLGWLNFYSRFIENYSILVSCLYEISDEELRLGLVSPAAVRAFANLKAAYSSTPLLRHADPEREFHGLLYTTTWAISATVCEDYDGVLHPVRFCGRTLKGGEPRYEEWAKEALALLRAVKVCYYELRNMQLVVYSRHGLLKWILADKHGKADHLPWAAILSPWTIRVEQVVELDERWVQPIRLVDILHPPDASTLADMDVYRPNKAKDIQVSQRQATLPQFAPDERATVVAFDGAIKAKEKVGSYGFVIWQLPGWSVLWVENGVLADATVNLAEYNGLIAALERVLSLSVVNPVIFGDSRLVIHQVLGWMQSKQSHLQHCLDRVRALRDQATGVEFHHVKRELNGAADLLAGLALQDRTGGQVLDESILEELRRRNLLPELLQPATTAVAPMIMAFQAKSTEKMAALRLDRVSKAQDRERELANIKCYLRSEVSHLTEAECRVLPKLAGQFEIGERGALYRVEWSSKRSPEERMQWKLVIPRVLVKVVLVHCHDDAQGGHAKFQRTYERARAHFYWRLMYADTKDYVADCAVCNTAGPPPNFRALSPGNLMPEGPLDVVCMDAATDMPLSFRGNTQLIVFADVFTGLIMTKATPNRTAHTVALAFEEVVFRRFGACRELRHDRDPSFMSNVFKYFCEMLGQRQMPTFAYRPQANGLAERSIQVMIRAVKHYVQDPKQKDWDDWAERLVFAMNTSVSVVRKETPSFLMHGWDPHTTITASLPTIRRDAEPEAYRWRLQVHQQQVYCHALNRDLVAAAIANRSRRHNAQLPEDVDERIKVGDAVWLYIDQVKPGVKVKLAHRWHGPFRVLSRPNDYSSELESRVRHTGKVYRFHAIVHDSRLKPRRIYLERPVEVLLNVPEMDFDEELALPDDSFLGGRPDRDDVLGSRPQVVAVRNVRYTEDIKEYEVQFRQGGPWIWEALVSISPTEFIYEFERVRLGFDRLAMMVQEELHPIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XNE6</accession>
    <name>A0A6G0XNE6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Non-specific protein-tyrosine kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_003025</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000034">
        <property type="protein sequence ID" value="KAF0741833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XNE6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000851"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
        <property type="entry name" value="FYVE_like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF611">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="START" evidence="8">
        <location>
            <begin position="139"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="7">
        <location>
            <begin position="263"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="710"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="434"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0741833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="974" mass="106603" checksum="F9B9EDCCB6C99F1F" modified="2020-08-12" version="1">MAIRREFTESEISSLKNLGREVCTIVAYAARRSDKSTVRWTPVTPTSASDPVDVYIGECPVNDTLTFMCGVTRVHNTSIDQIAMLLNTEKEQTPAFHGSFYGDLSHYETVTAVRRQSKQFPRHAILVKAATMPSPSRTIQARDFVYLEAQEDIMDTTRKTRGWVCAMHSIDIATRPPREDAVRGRLFRSGIVATETQEEGVIEVTYLLQVDFCGFVPLDVRLRMMGLRLHSLRFLGDHFRNLQPIRARSSSSAPSSSNESRSSMSSKSCSCCGAKFHLLQRKYTCRVCQDVFCSHCGSHQRVTPGIGVEKYSICHTCMVKSKQTTFDSTDPSTAIVVSEMSAGQIQTPPPPPRPPIANVGVRQNSGMQRSSELRTSLRTSAVTTSPNVYSGDIYDGTDIGTSTTPQSGTVVNLADVGNATEILAAIAASRQPQVPILRQSPAESNGETPRPLPTDDLDDEIDGHSSSYIDTESEWRGQVGPIRSRQSLTRSTSNVVDLRDLTNASELLQALDPVASTIPPPPAFPQLQNAPANAKPSGQYTPESTTISVATLPPLASDEDAVQFRAYAPPCVGRGVAFDFDLWLHLVVAGLHEDDDEVSKPTTVPFRRGALLHVTLTAPEGFTVAAECQTQIVSWLGESTNAKFRVESTQMASVGQAVLTAKVVCGTRVAVVRSFVFVTSNRGSSFEVAQLRHEDSLLPLAHREIAFGELKLRNLLAFSQSGYSYRASFESLEVVVRMVRPNQYGDENDRIVAEFRREAAVLAMLGHHPHIVSFVGASSNVEEPLTLVSEFVSDGNLEYLVQTTRLSLAAKNRILCDAALGLLNIHEGGFVHRDVAARNCLVDPSGRAKICDFGMCRPAESPEGSYAEDGGMTPLKHMPPESLQPPHLYSYKSDVYSFGVMMWATFTEEKPFANLSGAEAAAWVLEGGRLDHVSAIPQAHRDIMAQCFQEDPAKRPSMADIVAHFRTLPSDSMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XNT7</accession>
    <name>A0A6G0XNT7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_002792</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000030">
        <property type="protein sequence ID" value="KAF0742120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XNT7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000204"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029208">
        <property type="entry name" value="COX14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911">
        <property type="entry name" value="ACYL-MALONYL CONDENSING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911:SF79">
        <property type="entry name" value="MOBA-LIKE NTP TRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14880">
        <property type="entry name" value="COX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="515"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="547"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="590"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="638"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="663"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="705"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="734"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0742120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="862" mass="93658" checksum="F5E7DEDEB6741502" modified="2020-08-12" version="1">MCASRPASKDLNRQMATTTKGQVFPVNLRRASQLAGISYEDLVSGMHPDDAMRMQGVYIEVDDDNERLEQENDDAIAFEGQLDALLLTSTRTTAFGIPLDLQQLEGKSILEHSLLQLHLAGIDRVVLAVTPDSECRAHIEASSVCAEMTIVFLEVTSKVLESIPETVMAARHSFSSHFVIHAPNRVFHKDLLLRLDACHRRKLSACFLIEADRSVEARMDSSKVRVQCTPQTADHPPKIHVGRDIPDYTGVDVGLYVVSNKIFLVLDQLLDRIGGLSFPESLAFGFQKIQCLAVGNSIWFGVDSVAQMVHAIETNVLKRFAVSTAPPERRRKSIILSTDSSQNEANLQRRSSCADKIEPFQAFVVDVKSTSLPHGDEAEPLLMPRRLSIKVANESTAEMISTNEMKLTLPPGSADNPHSSAYLIQRPSSAFVLAVPDNAKKPRMSMIRRLSALPSDIKEVSLEAAVVDGKLAVQLTVQKQVPPIGYVILIGALLSVSSQGAALETLAEVPALLKMVWRYFGSSLLFGALTLLTTVDSGGGAPPLTFQVVRDAIVCTAAYVIFSSTFIWALDHTSVGHAYIFSNSHSLLLVFGKCLMGESVASMELSGAMLGLLGGVITSQDHGGDATGAHNPTFQGDAVAFLGAVGGVVYLLYATALREIMGIWLFCFYLFTGTWVMLLPFLWALHVPIDLSTDPIHGFFGWVHYLGIEIVLVVIVSACGAMGFVSAMKYFPPIVVSVTMLLEPVVATAICIFFGMASLPGILTFIGGSAVIGGTFLPIKTHWTIKYGQVRALFVFEDVRHMTAAAKVADAAHKIVITGLLGATAFGLYDVTRGFTVMYTRNIERQRAYEAEQAKLAQPDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XNX5</accession>
    <name>A0A6G0XNX5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_002786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000030">
        <property type="protein sequence ID" value="KAF0742114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XNX5"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0742114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="116" mass="13006" checksum="982DBE51F7BA3C05" modified="2020-08-12" version="1">MRLGTGRLRVQIPQPTPWVVVYSKSSSLLGRLQSAPHGRQEIIVDVPITRRPAVPAWALPTAGRLRSSYKYDMSTHKEDISIDQARPPKREQTAMNSYPPMTTSDLRNLCDIQGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XPG8</accession>
    <name>A0A6G0XPG8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_002738</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000029">
        <property type="protein sequence ID" value="KAF0742336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XPG8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016019"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF68">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATG1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="87"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="166"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0742336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="444" mass="49931" checksum="7F6660620AB3FCD3" modified="2020-08-12" version="1">MASQLRRVLSDSSLNRRMCQHSPELEEAKQWADYRRQRVLESYGLPRGHSNDPAKMRCRHTTVKEKLLHSSVSIAKATHGWMLPYVCSLCHTPGATCLIAECGHYFHGSCIVRWVGSHSHCPKCDRFIDLFIPAHLTLHPPRFRKSFSCFSKGPDFFDNDFDQRYEVSKLLLGKGTYASVYLGRERSTNTPVAIKRVLKTGLKSDLENVKALEEIAVLHGLHHDHIVNLHAAFSSPTHYMLVMDHVEGGTLEDWMHAWVDGQSSLGPRGHKRPLSEAIFRCVMRDVISALVYLHTIAGVVHGDIKPSNILMDRSFNVCFPVAKLCDFGNAVRMHPGLPLQQDIAGSFGYMAPELLCHETAVTPASDMWSIGLVAYEALVAFTPFYPYNTCTTDAATYPRRDFKHISPQCVDFLQKILVRDPTKRMTAQQAASHPFLNIAPCMCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XPS2</accession>
    <name>A0A6G0XPS2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Myosin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_002692</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000029">
        <property type="protein sequence ID" value="KAF0742289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009415"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF845">
        <property type="entry name" value="MYOSIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0518">Myosin</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="9">
        <location>
            <begin position="71"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="6">
        <location>
            <begin position="713"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1234"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1048"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1296"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="164"/>
            <end position="171"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0742289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1360" mass="153428" checksum="AE04B2AF4FCF0B8E" modified="2020-08-12" version="1">MSSSNTTVPQVGSLYWKQQGDDWVLVQVEAVAADNITFQLVDETTGAPVAQNAQTSATATIQLAPANPLFVTCPDMTSLRHLDEAALVKNLHDRWVDADRKPYTRISNILIAVNPLRYSDKPIDKTPYVHQSLDKSPPHPFHIAENAYRQMRSLKQNQSIIISGESGSGKTETSKIILDFLTERSGLVKVDDKAQACQYDHTLGDRLMETIPILESFGNAKTHRNHNSSRFGKYMRLQFSKNDGNDSVSKLQLTGASIDTYLLETSRVVQTPVGERNFHVFYELLRSGNSAQLEELKLIPSPYGQQPLDTSIDGYIAQFHYLKQSGCTTHDAIDDKANFVKLLEALKHIEIDTADLLRVVAGILHLGNISFDEVDTSEGTVAVIHEETEAMTGPLYVAADLLGLNAESLRDAMLKKKISRVANVGGGLSGRPTMQRAGSVYIVKKDLRQANYSRDTIAKNIYEQLFASLMRQCANALEFNELERDTLPYIGVLDIFGFEDFEPKNRNSLEQLMINYANETLQNMFNHCILKNEHELYQLENIYAPQNAALRFPIFKPNSEAGDFLAKSKHLVVQYEDNKDCLNLLAAKNEGMFSVIDTVGKLAGPSDRKLIDRFHTLFTQNPCFIQPHPKDLKHTFIIKHFAGPVRYNITSFLDKNNNIASPQFDDLIKGSSLSILSTTIVDRTVETSPRRGVASHQPAKVLGSVTQIFSQQMKGLVLELESTRSNFIRCIKPNTAMDPAVFDRPSVLNQLRCSGTIQACQVLQVGLPTRVTYDELLATYTNLLGEDFMEQFQEDGRLFARALCYILDFPTDDFRLGDTKLFFKTGKIHLLDTILHVSPTISTKDLGLQLRKYIAKHRWISAVTKVVVLRYAEKTFLQVQLARHVVVLQCWFRQILARKLVSAMKTHQRIAKAWGSVFTKLRIRHAFDSNLEDKLQLLKTLESHPKLPDNRQWLLKWLEPLQRSLYAKKVGRAVFTAHLCKRAFLTLFDRVRENRAVVKLQSHARRILATKKYNLMRQHFRAQVNWSNLRTWIKGRFVFCALYRRVHLRRLEVDNEAFRAEIATLKAHQAELEEVAKSAKDAQANLTADNTRLAAELAASQEITASWEAKFNDIQGRYNAAQELASAEAARASRAEAELLQVRTSSSELQTKLEMSIADASKLAQTLEQELSEAKQQILQVTEAQNVNKVTIENLHGENTKLKEENAALAERLSTLAAKLADADLERQNLKNALEQSSAEVDSLSKRVGQRSNQDDNDVHNSILQVKVIRTEEVESSPEPSPKANQSGSEDEPSRRRSRNQNRGPRKPQPPVVETLSGVPITSLHFGKRSKKVQMKEEKQRRSRSPCRPRPVLVHQSSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XPU2</accession>
    <name>A0A6G0XPU2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_002606</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000027">
        <property type="protein sequence ID" value="KAF0742513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XPU2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012313"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05300">
        <property type="entry name" value="2-Hacid_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000363">
        <property type="entry name" value="D-isomer specific 2-hydroxyacid dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43333">
        <property type="entry name" value="2-HACID_DH_C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43333:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE NAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="3">
        <location>
            <begin position="125"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0742513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="332" mass="36655" checksum="E0F90E5949E48025" modified="2020-08-12" version="1">MTRVFRVLVASRDTALPEKVRQALAALPASLGVAELELQSLDISQVTGSEPLNAASLDLLAEARIFLSEPRVAPRLLPHAPKLEWLQSIYAGIEPLLAQPRRDFIVTRAGGIMGLHMAQYVLGWVISKERMFHLAPQYQAKKEFRNAELHYRHYDNVTVGILGLGDIGLEIGNLINRAGFQVVGLKRSGLTESRERFSVTSDLKTVLSTSDYVVNVLPSTPQTRNLLSGNVLQACQAKQPCFINVGRGDVVDEASLVHALDEKWLSSAVLDVFAVEPLPVESALWEHPQVTITPHVAALSMAEDVAAIFARNASHFLAKTEMEYKLEWDRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XQU4</accession>
    <name>A0A6G0XQU4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kazal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_002425</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000025">
        <property type="protein sequence ID" value="KAF0742725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XQU4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016967"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050653">
        <property type="entry name" value="Prot_Inhib_GrowthFact_Antg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10913:SF45">
        <property type="entry name" value="FOLLISTATIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10913">
        <property type="entry name" value="FOLLISTATIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00050">
        <property type="entry name" value="Kazal_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0722">Serine protease inhibitor</keyword>
    <feature type="domain" description="Kazal-like" evidence="4">
        <location>
            <begin position="2"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="4">
        <location>
            <begin position="56"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="4">
        <location>
            <begin position="99"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="4">
        <location>
            <begin position="155"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="4">
        <location>
            <begin position="200"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0742725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="245" mass="26094" checksum="DF889FFD58DE926D" modified="2020-08-12" version="1">MIATILACDDQFCLDNFAPVCGSDGQTYSNKCNFDKAQCVNPTLQLVLNDTECPSPLPLCFRACIEIFDPVCGSDGHTYANNCSLANAACLAMGQNLTWVSNGSCCDPCDLACTKEINPVCGSDGLTYLNPCLFEQAKCRSPALSLASRGACPTRCEKTCPMIFSPVCGSDRVTYSSSCALYNVACTKPGLTQVASGACPCERVCNQMYAPVCGSDRRTYNNACLLQNAACKSSRLRIAYNGPCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XRE0</accession>
    <name>A0A6G0XRE0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tubulin/FtsZ GTPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_002181</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000022">
        <property type="protein sequence ID" value="KAF0743124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XRE0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009964"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02190">
        <property type="entry name" value="epsilon_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000007">
        <property type="entry name" value="tubulin epsilon chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004057">
        <property type="entry name" value="Epsilon_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01519">
        <property type="entry name" value="EPSLNTUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="6">
        <location>
            <begin position="33"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="7">
        <location>
            <begin position="229"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0743124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="417" mass="47140" checksum="095387ADDF5CB90E" modified="2020-08-12" version="1">MALEEHAQNAKNEMFDESMSSFFRNVDNRGSDVPLYKSIQHLRARAILVDMEEGPVSETLKGPLGELFDSSQFLTDVSGSGNNWAHGHAMYGPKYKEELLEKLRYATEMCDSLQSFFIMHSMGGGTGSGLGTYILSLLEDNYPEVFRFTTAIFPSADDDVITSPYNSMLALRELTEHADCVLPIENEALFDIIDKHPSSGKETAFDKMNSIIARTLTHLTSSMRFEGSLNVDLNEITTNLVPFPKLHFLLSSLAPLWPDKQPRRISQLFLDVFQRDYQLIKTNPKSGMMLACGLLLRGNVAVSDIQSNIQRIQADLRMIPWNSEGFKVGICAVPALDHPVSLLSLSNNACIVDTFERMQARFDKLYRRKAHVHHYMDYMEKSAFDEALENIKWLIGEYHKLNDTIECAAPPRPKPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XS95</accession>
    <name>A0A6G0XS95_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helicase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_001808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000016">
        <property type="protein sequence ID" value="KAF0743473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XS95"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004006"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005114">
        <property type="entry name" value="Helicase_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37066">
        <property type="entry name" value="HELICASE-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37066:SF1">
        <property type="entry name" value="LNS2_PITP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03457">
        <property type="entry name" value="HA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase-associated" evidence="1">
        <location>
            <begin position="113"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="1">
        <location>
            <begin position="358"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0743473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="515" mass="60498" checksum="2BE9E799459B49C4" modified="2020-08-12" version="1">MLLRFGVQVARQRWTLRTISTWTPSISVQRQEDILRVAQCVHELEGRPERTNLSPNNFIVPEEEPFPEDLQGQRFDISVLRRAKQLGILDAKTVAEFDAIGFVWKGNEYQLNQQWEENIEALHIYKAIHGNLIVPNFYKVKEGDTQWPQKFWGKKLGYVVRAMRTRQDTMDPVRRDILNSMGFVWNTSRAKWERNLLALETYKVIYRNLLMKQSFVVPDQDPAWPKDTWNMKLGLLVYSCRRTKDDLPPEIYDALNAMGFVWKVRDKGTGPGQPPIFSMSKQYEILEILQAQQKLQGHTKFTTLPRTFKVPSSSEWPQHLHGCIVETSKFRKAYRMCLLDALVVDQLDKLGFVWNDNQHQWSLTMEALRTFKKIYGQVEVPHVFEVPEDDPEWPVHLWRMKLGGKVGSIRSRQTELTLEQRQELDALDFVWDSKKLRQNRILTTLKTYQMKYDNLFVPHKFVVPQDDPDWPSDLANMHLGAIVNRIRSRKDLLSVEMKAKLDELGFEWGGNERRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XSC9</accession>
    <name>A0A6G0XSC9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_001962</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000019">
        <property type="protein sequence ID" value="KAF0743273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XSC9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019773"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10527">
        <property type="entry name" value="SET_LSMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1420.10">
        <property type="entry name" value="Rubisco LSMT, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015353">
        <property type="entry name" value="Rubisco_LSMT_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036464">
        <property type="entry name" value="Rubisco_LSMT_subst-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF137">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09273">
        <property type="entry name" value="Rubis-subs-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81822">
        <property type="entry name" value="RuBisCo LSMT C-terminal, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="4">
        <location>
            <begin position="19"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0743273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="399" mass="46367" checksum="69C543787198F8A5" modified="2020-08-12" version="1">MEAEQRFIAWLNEHGAELDALEIASSLSGSRGVIATRKIAENEVCMKIPSKLFISEASVKEDPVLAPIFAEHPDLFTRDDPLLSTYLVYHFHLAEASFFFPYLSILPEPESILNWNKDDLIQLQDTKLLEAVERRNHEIEDWYTRVSTRLFRLYPDLFNTSSFKPKRFRFAWQTVQARTFGRRLPWTALVPFADMLNHANVATRYDYDIDGNSLFQWRSSQSHNAGDQVFNSYGRRPNQHLLLDYGFALPQNEWDYVDFDISLMEYILPKPERRRLFLDAHIMPSPSKLRLVPDTTLDEVLPFYRCACLTEVTQDTSLLEVQDTAVETQSLYLLRDQLTSHLTTYVTTIEEDAFLLSDNNVQGNLRTAIQYRWHQKHILHRIIGLANSKLCPEATTPME</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XSG6</accession>
    <name>A0A6G0XSG6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_001821</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000017">
        <property type="protein sequence ID" value="KAF0743344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XSG6"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0743344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="73" mass="8359" checksum="CCD9CD60443980CB" modified="2020-08-12" version="1">MGPLRHDSPLHILGEFTHGWRIQVSNDQLFAGFSVSHCHLSNSSDGRKVDHQTSIKVNHDLEDKLIEQEKQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XT29</accession>
    <name>A0A6G0XT29_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_001438</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XT29"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002678"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="28"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0743787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="392" mass="43233" checksum="61E7E04076BE16E1" modified="2020-08-12" version="1">MTSNSIDAFKEYLKHLQDTGQVGSPVEITLDHFSFRKSSSPPNEPSYILHDVMGTLKPGTMTLVLGPPQCGKTALLKTLAGVFHYKGQSTPQISGSVTYNGQQLSQVHDLVTFVGQTDEHIPTLSVLETLEFAHACRGPSRSAEWQKSAIAVIDALGLKTCAHTRVGNEMIRGISGGQRRRVSLGEMLTCQSPVLLLDEFTTGLDTTVALDLTKKLRTICTMLQPPPEVFELFDNILLLNGGYVAYFGSRAGCLAYFSSIGYDCPARMDAADFIQQVSTDLGKAYHRSANTIELPSTSTPAEFHQAFKASTSEHKIAFVKPQPNSSFTPRKIDKSIWLQLRLVFSRQFKLVQRDKRFNRVRILQSSAFGLIIGSLFYQMGDDANMSSPRLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XU69</accession>
    <name>A0A6G0XU69_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_001612</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XU69"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000805"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="5"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0743972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="237" mass="27268" checksum="4DFFA9629F579117" modified="2020-08-12" version="1">MDADEPKDERRRQQSKMNQRAYRRKKKGSEEQLENDVLELARANDRLSSHILVLQRGLWCHAEHQAIVEFYRLFAGGYDKSPRQKTFLRYFVYRDVWFNGLTGVETFLAPWEQYATLFTSNHVDCKHIADVSSSSEEVIVHAEIVATLHFGMQTIETLFPIAKTQHEFTAALRGWNLELPIRVMYTFDDAKTVKRVNVETDLIPALLRQLGNLDSVLAVLALAGENRESMQFPALGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XUI8</accession>
    <name>A0A6G0XUI8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_000821</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XUI8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002464"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08215">
        <property type="entry name" value="STKc_Nek"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="7"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="400"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0744333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="479" mass="53343" checksum="DDFAC1FFC7762DC0" modified="2020-08-12" version="1">MGSLADYEEIRQLGSGLYGDIYLCNRRSDNEIVCVKHVDVTHLSQEQRDGCWNEVRISEELHHPNIIAHHGAFLDESPDCGAILGIVMEYCDGGDLAEWLYRHHQSLDEATVLPIFVQIAMALHHIHRSQVLHRDMKPKNIFLFENGRVVVGDFGISKCLDPSKGGLAQTLVGSPAYMCPEIFEGKLYGLKADIWSLGCILYEMLTGKCPFRASSYPSLVQKITTCSYDPLPITLRPCLRQMVSSMLSLSPNDRPTMDEILLLPFLQRHIQHYLAHGHELCPVSSQAAARQILQDQYDSLHPPIDPTSPRALVRPSAEIAASSPEDIKAFVKSKMIASVSDASLDSKAIVQLRALQAAQKYKQRSATKKTSLNLPLCDIHVQQFARDVAPTALTHINFQPTPPVFKPRQSKKFVPDDMAPKSPRHRPKTIRGVSPPPPPVVGVRPAVPSSPFVLDLSPNQLEMEVVGIQIKSTSKRHYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XV39</accession>
    <name>A0A6G0XV39_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein-serine/threonine phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_000887</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XV39"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012055"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008579">
        <property type="term" value="F:JUN kinase phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46377">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46377:SF1">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="3">
        <location>
            <begin position="24"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="4">
        <location>
            <begin position="85"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0744406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="166" mass="17895" checksum="239CFF5493DAC005" modified="2020-08-12" version="1">MALLCGQDLIAHARLGVLQPRRVKLSEVALGLFLSGGASAKNLPLLREHGIAAIVNVGGGKCHFANAIVYNKIGLLDKSDANILPHLHNACDFIHNQLQSSANVLVHCMGGFSRSPTVVVAYLVKYRQLSVDDALTVCRLAHPRANPRPNFIAQLHDFQTQCASQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XVB4</accession>
    <name>A0A6G0XVB4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_001067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XVB4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009477"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="697"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="703"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0744600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="721" mass="80326" checksum="5B857AB7E51DF1F3" modified="2020-08-12" version="1">MDAVVDEMLFPEQDLNPYQAYNTGNDGEIDGDVDEPFLPVSDTLEIDLTHPDDDDEPDVLPQKRSYDAPDQAELSKRMKSDSWSAPVEDNSRRNTLGEASPPQSEPTSLPQSLKVEIPPTIDLATESHSGTDVVMDDGIKPEEVLNVNKAPVASNHNASARMTDSKLEVAPQEHAANKVEAASLLQRSSKQCALCRSKKGNVVLCVGCWIPVHSHCIQGKKYCGSCTIALTARGDVATVAEDPKTQAIFKGLTYLTSITSDPDKFRLVGHVASVYLSDLASIAPPHIKQLAQKLQPQYAHQWLATTLVQVQIPDVKLSTKDITNIIVGLFGLKRSKLSNALTDALQKHVEHYSVVDYLGWDPSSETPDIKYSNLCGGCGLRILRSQMKCISCNRVLVFTSKFEGFRASIVLAYHAEQVGVSIGCSFLDVFKHWPVLRRAYLQTARSIYEQALFCDQWRMICTLLEILSLHGARKLPLELLDVEYKILSQREELQRWVNTGNLDLFGNALFCLRLFTETPDVASVIESFQSLLLEKQHPTLGFWGYQDAIFPFVDILRYKATFSCLKALIPLRTIGFGPAHVDYWAYLQEWSRQKAIPCGIASSTRRFGNLRDLYRAQVVTETETNPLHAAVQMHLKGRAQPSTTTNGAVQVSSGWMRYTRDVWDKPPTGNDRNVLTMSDLSIFDGLKFEDGAVIDLSQGNGLDEGEDVVDDDDEEENKEDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XVJ4</accession>
    <name>A0A6G0XVJ4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_000983</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XVJ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006552"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007171"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="129"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0744507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="286" mass="31468" checksum="9BE67A50A309434F" modified="2020-08-12" version="1">MSYPRGVRLACVSAEPSSLQVASSRSRGNQTMLHLDLLHLRPSHLFLTPSASSPFPLHFNGENFTPIDELSNLPYDKDDDEQSAKKHVSASTSGKLILDEARSEGRVSAAVFQGYLDAIGGWSVVAFWVFLLSTWQILIISGDRWLSRWSSTTTTVSETTFLAEALYYLIVYAILAASGVAATMLRTYTILMSCLRAPVRYFDTTPLGRLLNRFSNDMNTVDTQLPLLVSGGLAVIAMTFFQLATTVVVLRSLGLALVPLVVVYARIAAFYVHPARAVERVNKTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XVN7</accession>
    <name>A0A6G0XVN7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_001177</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XVN7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011293"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12402">
        <property type="entry name" value="RRM_eIF4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033107">
        <property type="entry name" value="EIF-4B_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF11">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="92"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="167"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="180"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="259"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="322"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0744720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="368" mass="41400" checksum="3C1C8911A6288448" modified="2020-08-12" version="1">MIKSFQSMGSSSWADDDELDEQPTAYAKPAAPIHEEHVIEEEPREEQAPPPSRGNSRYNDEYEGGRGGRGRRNSGEYHEKREKLPVPEVGPFKSYVGNLPYSISEDELAEFFAGCNVTDVRIPIDYHSNRPKGFAYMEFADRDSLIHALEFDGKKINQRAIRVDVAGEKKGGRQDSAFFQKRDNYAREDRHQRDDRYQREDRYHREDRRDDRRAEHDQSGHQDEAPVERRKLALAPRSKSKDETDAPASRPSNIFGNAKPRDERNVKPVADRPRQEAPKDQREQGNRRGDKRGDKGGRGDGKQSRAEGDWGRGNAAASAAPQEKKAPKAKAAKAEREPAKAAVFKPAPTTTKTVNAFSALGGDDSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XWF2</accession>
    <name>A0A6G0XWF2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RCC1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_001232</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XWF2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002974"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF466">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RCC1-like" evidence="4">
        <location>
            <begin position="279"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="279"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="342"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="395"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="454"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="508"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="568"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="620"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="16"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="685"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0744778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="914" mass="100976" checksum="D3ABC4C40B7BB238" modified="2020-08-12" version="1">MEIALLRSATYVEDKYNELKRKRPEEKESDSTKDTPSSSYLPAIGAMRLDALSSFRLDKQGPTLPPEDRKKLNEAIQELEGMWPVTLLEKKLVLLYNFLDQMSSMKSARREHMVPINKDKLALASVTTLESLPLSTQLAVKLFFRLIQTIRSRSQACGNYTTLLRLIHQLPRMLTDLPPLSLSPEQHLQTNDKSIFEEIFNTVQQVPTSSREDQEAALSSLLGLSIKRGRLYHILLVIRLLLQAPPTLPMQLAYPFLQELTEAKPEETDDSTDDGQRVGYLMSFGKGDHGKLGHGTCNHPACADSKCTENKIIPTMLESTRDLMFKKIDSLSTHSVAVSVHGELYTWGNGEKYRLGHGDATKEYTPRFVEAFRSKPRVKDVACGLGHTIVLLVSGEMYAWGNGGNGRLGLGDMADQTAPMKVPFPDEIDRDRDNASIVAVFCGASHSLAINQQGRLYTWGKNNQGQCGHGHTNDQLTPAEVLYFDDMEMHVLTVAGGWEHTLICTTNGKAYACGCGYKDSRRAGLPPVLGLGSNDTERRLKPTLIPLLDDCTAVACGWDHSLALTRDGSAYSWGSGSNGKLGHGDEDNRDIPTKILGLQGKYIQEIKAGCEHTTAITDSGEMYTWGHSDSGRLGHGDNLTRKTPSFVESFAWQGYRPVSIAVGDKYNLVLVQPVVDGAVRANNQTATNTQGKTPRSVAPSAPDSTIPLTAVTLTSQLMHQLDRLSNAYMPQENSQLLERLKYLYMHPITSPTALAYAVDISNDTFQLLVDIISTTNMKAESDDPATPRAASLSSKVLARSSLVLTSLRLIKVNLYQLLSCSHLALSPSTLMQLHDLLSGLATLSMKEDIHEINQCSADALKIGFQIFYPTGAEQHHLLWQFMSANHTADLVLRQALTDRLCQVRLYNEACCNFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XWS2</accession>
    <name>A0A6G0XWS2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Argininosuccinate lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_000594</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000003">
        <property type="protein sequence ID" value="KAF0745014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XWS2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004128"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:L-arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000002">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000001">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000015">
        <property type="entry name" value="argininosuccinate lyase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00006">
        <property type="entry name" value="Arg_succ_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814:SF1">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00145">
        <property type="entry name" value="ARGSUCLYASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="2">
        <location>
            <begin position="11"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Argininosuccinate lyase C-terminal" evidence="3">
        <location>
            <begin position="366"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0745014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="460" mass="50494" checksum="8496CC76E477B5C6" modified="2020-08-12" version="1">MSGGGKKLWGGRFSGELDPVMNKFNESLSVDKRMWAADIRGSKAYAKALEAAGVITAEENQSIQDGLTKVHEEWEKGTFQVCAGDEDIHTANERRLTELIGSAGGKLHTGRSRNDQVATDVRIYLKDAITGLFHQLKELIGVAAQLAESNVSLLMPGFTHLQPAQPIRFAHWVMSHVAALQRDSERLTDLVKRVDVLPLGSGALAGNSFGIDRALIAKELGFARISSNSLDAVGDRDFIVEFMFWASMTMVHFSQLSEDLIIYNTLKFVTMADAYSTGSSLMPQKKNPDALELLRGKSGAVIGRLNGLMITLKGLPRSYNKDLQEDKSALFYVIDTMVDCTQIAAGVLATLTPNEAKMRSFLVTEMLATDLAEYLVRRGVPFRETHHVAGAAVRLAEDTNKPLSSLTLAELQSLHPKFEADVMDVWNYESSVERKNVPGGTSEAAVLDHIKEVKAWIAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XWW9</accession>
    <name>A0A6G0XWW9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tubulin delta chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Delta-tubulin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Ae201684_000571</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Acts as a positive regulator of hedgehog signaling and regulates ciliary function.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000003">
        <property type="protein sequence ID" value="KAF0744987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XWW9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001825"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030030">
        <property type="term" value="P:cell projection organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02189">
        <property type="entry name" value="delta_zeta_tubulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002967">
        <property type="entry name" value="Delta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01224">
        <property type="entry name" value="DELTATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="9 14" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6 14" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="15">
        <location>
            <begin position="26"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF0744987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="407" mass="44959" checksum="BE691AC2BAB0E734" modified="2020-08-12" version="1">MSVFINVGQCGNQVGAALMALAKDPQGKKRSEHLRCILVDTEPKVVRSIQFPANVSAVHMEQSGRGNLWAMGYNKTKSKELCARVMESLRREIEAMDCYRGSFLLHSLAGGTGSGLGCRLLEKIRGAYPKAYLVSGCVAPSLRGDTPLQNYNALFTLRHLQDFTDAVLFKDNDDLLRTVSYWRGTQSKPKTSVSLGEINASLAADWAGLLFPTIQSKLRRVFDIGSFVTRVCPLPEAKFVDVRSAYYISKARSVSFAQFSTASHQDVMPLARQLVESFPRTASLAIGQHVVARGFKDQSMTAAADAMRKGVRCADWGVPSPSLQLSSSPLASSVLSSLTMCSNGTNIAPVLRTYLDRASTQFQARAYLHWYEKFGVDKAYFEESFGKTEDILRHYDTLTQPERLPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XWY3</accession>
    <name>A0A6G0XWY3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="3">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_000272</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XWY3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019654"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000010">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151:SF90">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 3" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="4">
        <location>
            <begin position="34"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0745240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="439" mass="46051" checksum="2012F63FB9231B81" modified="2020-08-12" version="1">MLRRVVAQPSIRSLAHRGRWCTRRAAFSSLPDGVTKLLMPALSPTMASGTIAAWLKKEGELASAGEVLCQVETDKAVVDYEMQDDAFVAKIVVPQGTSVDVGTLLAYTVEDQEAYDALVASGDIAKLTADAGAASPAPAAAAPATVSTPAPVAAATPAQTHHRVPRIKFLGKRSLLPAHAAPVHAAAPVAQAAPVASPAAVATPAASTGDFTDIPLSNMRKIIAKRLTASKLTAPHTYASIDCEIDAIMALRARLKKQHGVNVSLNDFLLKSVASALRDVPEANCGWDDATKSVVSNPSVDIAVAVATDSGLITPIVPKVQALGLSSINSTFKELVTRARANKLKPEEFQGGSFTVSNLGGFGIDNFTAVINPPGACIMAVGRGRPELVVPDDESKPPRKATLVNVTMSSDRRIVDDVVAGQFLQAFKKYMEEPELMIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XXF3</accession>
    <name>A0A6G0XXF3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TAZ-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_000307</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XXF3"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0745276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="125" mass="13811" checksum="E8A1018BC232A943" modified="2020-08-12" version="1">MCCVPSRNMSSSKVLSIPSLCHVSVTASETATASAIPHLRVSMHHNHDLKKRELVKKVTSVRKGLIHVQECQDHHCDKALCKSTRRLIDQYRTHGCVNSNSALVHDKCQVCLLWTLVTGNASIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XXU5</accession>
    <name>A0A6G0XXU5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CCDC43 PWI-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_000451</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XXU5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017289"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037666">
        <property type="entry name" value="CCDC43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058771">
        <property type="entry name" value="PWI_CCDC43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31684">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31684:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26091">
        <property type="entry name" value="PWI_CCDC43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCDC43 PWI-like" evidence="5">
        <location>
            <begin position="3"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="166"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="75"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="176"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF26091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0745434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="220" mass="25490" checksum="48436E18355F09E0" modified="2020-08-12" version="1">MATAFETWLCSRLNELSIDSEVYGEYVTGIVADKETDLEERCSTAVDVLRAVVEDETSLDTLAGEIQAQWIAQEQELEKLKIQELEEEKVRLQAEKQEELKLVELNEQKEAEKAQARLHMSKEEIYQREKLLREYGAVGDSEFDEDGNVIFKGQKSTEDVTVVNTNRTQGKIAQQEMREKMKKEHEAKVKREKELLEADRLRKDKAKKRTQKREKQRGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W4R1</accession>
    <name>A0A6G0W4R1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Endo-1,3-beta-glucanase btgC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Laminarinase btgC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Ae201684_018628</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation. Active on laminarin and lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000345">
        <property type="protein sequence ID" value="KAF0722148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011213"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF17">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE BTGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026353168" description="glucan endo-1,3-beta-D-glucosidase" evidence="15">
        <location>
            <begin position="17"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="17">
        <location>
            <begin position="597"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaredoxin" evidence="16">
        <location>
            <begin position="1245"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="770"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1042"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1172"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="783"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1042"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1112"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1186"/>
            <end position="1221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF0722148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1332" mass="145880" checksum="27F2DB1659843623" modified="2020-08-12" version="1">MKLAFALSALFASSAALDRKMYGVDYDIRTSEWGGCKNLWELRADFAAMKQVARNVRVYGTQSPCIDRVLQVAAENNVRLWLGLWGNIYADQDAFDKEFVTFKRLVAEGKIRSDNVVGMHVSSEAIFRYYIDDKHDWSDLEGTYKLTSYVDQVRKFLRQHNLNFPVTIADVMDAYKYLHLLYPAVDVVAANQFSQWESIWAKDGVNTMFERLKNIQISARAAGKQILIAETGWSANGSFPSIKEATPEASSLYLKDFLLFAEQQNLNFYYFTSFNLKWGDNSEFGLIEKNFGLFDQNRNLLPHVSRVVVGKVQKAVRLWHEGKVIKCDGANTDTIGRVYLEAPTSGLTDSLEREVWFYDEDHKVFRSKSTNQCLDTYVDDSGVSQLHVYWCDVTNANQHWEFRADGTFEIVSDPEVTLAPTTAKPTTTAPTPAPVEFLAECGDCRNCQFFTPYYSLCYANWSPYDCGLMPRTTHRWCGRLPAYVAPSPTEAPVQKANPVTSAHYLGPKATQVRIQVGSLISLSEKAPGKCIRAVDGDKQAQEVVDCSFDEPKSKFSIRPFETEETNIHIVDTDWKITQEYGKTTVTTIDSPSLYRDTQIWFYDPVAKTIRNKANSQSCLELVEDRIDGLVEGRLCDSENFYQTWSYNDLTGQIYFMEKMGLCLAITGPNEPLHVQFCDVLVKYQKWVFDLVAINGYPDRSQHKQPPLPCEYHNPTRRPVPPPCEYTNPTTRRPVPPPCEYATTKAPCTPPTPPPCTTTKAPCTTTATPIVAPTEAPTQPPTEAPTEAPTTTAAPTEAPTTTAAPTEAPTEAPTTAAPTEAPTEAPTEAPTEAPTEAPTEAPTEAPTTSAPIPDLVVTDAPAPTVEETPEPTKRTRRPLPSPCPKDEMKTTEAPETEAPPEEGYGYGDAPTETPEPTKRTRRPLPSPCPKDEKKTTEAPEGETTVVVKKHIIISHNKPKTKAPPTDLDLTQCTKHTVKEGDSSWAILNDSCGYSDACKEDALPTILNSKNERCSAILVVGEEVTVCCVLSTPEPSVTEAIVEETPAPTEAPTEAPTEAPTEAPTAAPTEAPTEAPTEAPTEAPETGYGYGPEPTKENLETEAPAPSTEAPTDAPTQPLSQQCSTNWSQCNGQNWPFGVCCQDPTFQCNYKSEYLSLCEPIGQAPPSVPDHIVETDAPAPYTEPPTEAPTEAPTAAPTEAPTAAPTEAPTAAPTEAPAKAPAPGGIPTEPVAFINYYIEKNACAGFGASWCEACEWVKETIADIGGQLAFLELDVQRKEGPSGDSISDALTQLTGSNTYPSIWIGGKYIGSSDKIADLDAQGKLEDLLKAAGCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W6V3</accession>
    <name>A0A6G0W6V3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_018850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000361">
        <property type="protein sequence ID" value="KAF0721863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W6V3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015431"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0721863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="408" mass="45022" checksum="EFF564C868BFDFF1" modified="2020-08-12" version="1">MQVLRALSTIRVEDLFSDHLFGHDPAAPSEADLLALAAPEASPQSTSETREERLFELFTAYAMQFSSEDPTSIRLVNVLKLLHDCGVVADTIATSSASEGHPAKELTIRQVEIIASKLLHTSTTCTKLTYDDFLKLLWDLALHVDPDAATPAAAFKQLVDQCVHRPPTKARARVSVESVYKQTDKVLTFFEPGLLEIFKCYADATHQTRCQQRNKLKKTPSSCAGSPSVKKVSKRPPAPNMALYLNYHDSVAFARKFGLVSHGGVTVAEFAASYIDSVEKINHTTFRQLTYLGFCHLLVRLAMRLYAAAATPETQLKALFQFMWLNSLDAPRAETTALCGRRDHSSARQAEGTATFRALFLKQWKRDSYIDYTAKGDAAPSGAVVGRKTAMKQALLEPPTSTLVTCSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W7R0</accession>
    <name>A0A6G0W7R0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_018076</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000320">
        <property type="protein sequence ID" value="KAF0722843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003580"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000289">
        <property type="entry name" value="ABC transporter G family member 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001374">
        <property type="entry name" value="Pleiotropic drug resistance protein ABC superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="551"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="585"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="618"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="691"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1103"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1144"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1176"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1211"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1242"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1333"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="89"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="771"/>
            <end position="1009"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0722843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1362" mass="153247" checksum="BC9E378EC92BDCBF" modified="2020-08-12" version="1">MSPSTPKVAESKKPLLDDDEQLPEVYNSLHFKSVQDPYRTVHSDRMSVYSTIHAQHGVESMLEGGLERFYEKYRHLSKKVNLHLATPEVRFENLSYTVQARQMTMAEKQGTVGSYIQRMFFPFKKAVYKEQVVLQPMSGIIKPGSMTLILANPGSGKSTFLKALAGKLDQNAKCVQGGEITFSGLKTSDVDPKKIVGLVDQRDNHAATLTVRETFKFADMCLNGSPESQPEELREVAKLRTEMILQLLGLTICADTVVGDALLRGCSGGERKRVTVGEMLVGGQSVFLCDEISTGLDSAATFDIVTSLRTWCKTMGGSVVIALLQPTPEVVEMFDDILMLNEGYMVYHGPRTSILPYFENLGFYCPMRVDPADFLIEVTSGRGKKYLAAEDRHRQIPIYAHEFNKIFVESELNKATLAELSAGFTVPGHLQTPEDFEKMKSVTAIARTKETSPFAMGFLESTLLLLGRQKTLWLRDRPLLWGKLAEAAIVGACMGAIYYNAPASIYLRMLFFSCAVFQRQAWQQIVIAYTLRSVFYKQRSRNFFRTLSYTIAESIVQVPVNLCVSLLMCTFFYFMSGLTQEAGRFLTFVVICVCFQHAIGAYMTFLSSVSPSITVGQTLAAFSVCFFLLFSGNIILHDLIPNYWIWMYWFNPLAWALRSVVTNEFYSDKYTLAEQSGNLTQVQMINFQSTYVGYGIIVLLGYYILFTGMNTAALHFIRYEKRYGVSGGSKVGEDEEDDNVYIEVSTPGGTMVKQERKKNQGLAFIPANLVIKNLDYYVTLPTKVERQLLNNITASFTPGRMCALMGATGAGKTTLMDVIAGRKTGGRIVGEIIINGEPKNPVNFSRITAYCEQMDIHSEMSTIGEALWFSANLRLPESISAEEKRNLVEETLDLLELNGIINEQVGDLSVEQKKRVTIGVEVVANPSILFLDEPTSGLDARSAITVMKGVQSIARTGRTVLCTIHQPSISIFELFDDLLLLQRGGFIAYFGELGKDSCKMLEYFASIPGTEEIRPQYNPATYMLEVIGAGIGRDTKDYSVEYTNSELCKYNVEKALRLALPDPEFVAFSTLNWTPMATSFSNQLKECVVKCAQTYWRSPQYNFVRLASFPLFALVFGTTFWQLPRETSAQIKSHVGLIYNSMDFIGIIHLMTVLDITCLERAVFYRERMSNYYGPLPYSLSLFTSEVPYLVVAVTIFVIVEYFTVGWVNSYFVLFWITFFLYTSICTFFGQWMCALCPNTKVANVAVGALSCVFNLFSGFLLPFPLMKGWYKWIWYIVPSSYSLRALAASQIGLCDNGDGNACQLIKGEAKFPNTTVADWVQIQFDFQPENRYYYILVLICMWVILQTFIYLTLKYVSHLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W7V5</accession>
    <name>A0A6G0W7V5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cyclin-dependent kinase 2 homolog</fullName>
            <ecNumber evidence="2">2.7.11.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cell division control protein 2 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">cdc2-related kinase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ae201684_018324</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">May form a complex composed of at least the catalytic subunit CRK2 and a cyclin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.23" evidence="2"/>
    <dbReference type="EMBL" id="VJMJ01000330">
        <property type="protein sequence ID" value="KAF0722591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W7V5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002177"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000415">
        <property type="entry name" value="CMGC/CDK/CRK7 protein kinase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF546">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="18"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="358"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF0722591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="407" mass="45482" checksum="92C4F1C8C8E4C219" modified="2020-08-12" version="1">MSLGLPQYGWSDSCIDVYEKIECIGVGTYGQVYLASHRDTGEKVALKKIRSLNEVQGLPVTTIREIKVLKAIQHRNIVGLREVIVTNELDGDVDEDSSDVPSGGDKAGPVPMDFSCGCIYIVLEYVDHDLTGLLDRQYPFSDIEIKSIMKQLLEVMKSMHAIDIIHRDIKCSNLLITTQNVLKVADFGLARSMLGDQPFTNKVVTLWYRSPELLLGTTAYDGMVDMWSIGCVFVELYIGRPLFSGKNEIEQIKRIFDVCGTPTISQWPDHPSLPYSSKFIPDSPLPNRLSEFIQREVAARSPPRELPPGALDLMLSLLKLNPNKRITAAEALRSRYFHTEPYAPDDPESLPPISCVASHEFQTKKIRKENNAKQRTSMPSSGGGRFPSPPPPPLDLAKPAKRRKETM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W8M7</accession>
    <name>A0A6G0W8M7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_018103</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000320">
        <property type="protein sequence ID" value="KAF0722872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W8M7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010648"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050502">
        <property type="entry name" value="Euk_RNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025">
        <property type="entry name" value="OS02G0815200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="2"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="114"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="74"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="236"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="86"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="258"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0722872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="439" mass="52917" checksum="5C7DE539F464AE3E" modified="2020-08-12" version="1">MVKVFLGNTPFYEDEVREEDLRDMFRKFGPINKIIIKKGYSFVDYEDQPSADAACREMNGCEFQGKKLRVSLAYSDDERKRNPPRSSGGYNSSSSSNYNSGSRHNESNDDKKCTSLFVANIPPDTTIDRLKDFFEKYGRVENVKVLPQKNNNPNISAFVDFEEYSAAARAHEADLNFEGKFLRTDFSTNRRYYWNLLVPWMVSIVPLVLWLFACFWDNRRNDDKWEDRGRFGDKKYDDRGRDLSPAPRSNRSRSRSRDRRDDKPRYDDKPRYDDKPRYEDKPRYEDKPRYDDKPRYDDKPRYDDKPRYDDKPRYDDKPRYDDKPRYDDKPRYDDKPRYDDKPRYNDKPRYDDKPRYDDKPRYDDKPRYDDKPRHDDKSRYDDKPRYDDKPARYDDRRGDGQDNGRDYRRNDRSEPPRSNGRAASPERSWSRGRSPPPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W936</accession>
    <name>A0A6G0W936_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein CASP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ae201684_017396</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CASP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000295">
        <property type="protein sequence ID" value="KAF0723822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W936"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018245"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012955">
        <property type="entry name" value="CASP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057476">
        <property type="entry name" value="Cux_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043">
        <property type="entry name" value="CCAAT DISPLACEMENT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043:SF2">
        <property type="entry name" value="HOMEOBOX PROTEIN CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08172">
        <property type="entry name" value="CASP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25398">
        <property type="entry name" value="CUX1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="561"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="Cux N-terminal" evidence="13">
        <location>
            <begin position="8"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="CASP C-terminal" evidence="12">
        <location>
            <begin position="367"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="124"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="316"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="443"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF25398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF0723822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="591" mass="67261" checksum="1B64671C6E229E85" modified="2020-08-12" version="1">MNPSTRTLLQTVSQYWKGFDLDSKRVMLDAQGVAMQEQKEHSLKSRKLLAEHTKRFRKLADPEKIPAMPSLLKAYQEEIDTLTKRAKFSDNAFFTLYKALYEAPDPVPALDAALDQLTPLTAAATDSSDEITKLRKELAAYETEFASLKNQDITIRNLENKLQQMEDSMDRMVEEQVDERCRDLEKTLRLREEDFEMNHAQLDKSISQARNERDDALAQLDLMRSEVFQVKQRLDQMQTMHMQETQSFVTEMDRLRAVQLENQLLKQKLETASTSTSFQEAPNVMHLELALAQKEAHLSSSLRELENVRASAAHEKQLWTAQVSTLEAQVASLEAQIARLNEQAKAAAAAAAAQVQPVQDTANARMAELEKQLAFNNQQWQTQQSELIAQLQEQEAQLAHQRQVIAQLEATLERAVPSESTDASAILGGVLLENDQTKETKLVSIMRQQRDRLKDKVKEMDTDLHAALAAKHQLTTRLKQLEHENVELVQKMRYVSNSTGATPDVEAGSLHKYQTLYDERMNPFDQFKQMESTARVAQLNPLDKILLVSARLILSHPYTRMGLLVYLLLLHLLVVLTLYLSMHLCNISNAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WBJ5</accession>
    <name>A0A6G0WBJ5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_016838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000269">
        <property type="protein sequence ID" value="KAF0724545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WBJ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016249"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0724545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="95" mass="11068" checksum="0ACB8B0D50BA8635" modified="2020-08-12" version="1">MKATTHDKGWQTLVVVSFVLSLVLLVAVQMTLTMLGWTEYRFLFVSVFGLTDTGLYTLPWLLGIFYWLLHHLTTEDPVRRHGRSRFIAKGRHGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WBP2</accession>
    <name>A0A6G0WBP2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_016758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000266">
        <property type="protein sequence ID" value="KAF0724695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WBP2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017965"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0724695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="197" mass="23362" checksum="B055CD1945660141" modified="2020-08-12" version="1">MAAALVTASEERPAFMSEEELEANGRILFDFQPQRGEDDEEEDEDEEEEDEPQERPAKRQRQEIPESERMIEIPRSLFERADKINAAILKATDNEDCGFMMFNTSSSYSMLKIFKKRNCRLEKICSRRKNYDVWYYDTDDIKGVESAFTTFHRLWTDIFKESDESIGLKGRHVLTEQLRQFGNSAREAHQYKFKWFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WBY7</accession>
    <name>A0A6G0WBY7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_016606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000262">
        <property type="protein sequence ID" value="KAF0724789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WBY7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017879"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0724789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="416" mass="47899" checksum="4C8A76EB60BA7B1A" modified="2020-08-12" version="1">MPRVKPSDGPWIVVNQLSALFNGLFAVKLLVTPFLVYLTEPFPWSPTQAPLHEWASFEKFNNGTFAYLSNIYNHDKFNSHDVCIKDSQPAHMLHYTNRFPGIRMPFYPEMCFEISPGALFFCLGISHFVNTFLGSTVEERKTIAPFQCQHFRYFGFARCDALYFGVVIWEGGAWMLFKFVYRCLVVIYIGRAMKRLYYDHFENLIVNLGKYGVVSKEVEYTQYEIVLGDPTCLILQDPIVSLVMVVDILMDLTAMSLGFLYTSRFVWARYFAMRYLSYAVKRYGWEESFEPVDPGILAIVTAWYVAPYFTLLSRTPLMVLFQFVWAICVPSNLKQERIETGPGSLVGTFFIAICPVAFMLSLAKLRHCKTGKLKHLFKRLIGSALIRRSIFSTKLQASVVVKPKSISIECWAIYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WCS6</accession>
    <name>A0A6G0WCS6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_016375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000251">
        <property type="protein sequence ID" value="KAF0725098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WCS6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019266"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="21"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="119"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0725098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="298" mass="34122" checksum="4B26BE7314008097" modified="2020-08-12" version="1" fragment="single">LPREDEDSSDVVHEVIDLTAESDEDETVALRPNENEKISELVSASADEPKNREHISDEEMREQVRAEVMVELIKQYEEAIELARRTKHEDEVRALDEIQRLTVEIVELKSVVTNISSENSQLNDLVTRKDEDIKRLEAENRTVRGEAEKSRFASQKPCSRCSSLEETLNQSIVDCENLRSALNTLQSEQSDIQVCEENLKKSAEIELLRRKVVDLMQQANTSLKEAEANHQGDIDQLEGEIEFYRNQYEKLVEKSDEKENKLLVELFELRRLCDGMLYLSYPTGRNPNAGTKGNEIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WCU6</accession>
    <name>A0A6G0WCU6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_016353</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000250">
        <property type="protein sequence ID" value="KAF0725122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WCU6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020273"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45617">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0725122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="333" mass="36863" checksum="CC9F347F9A30397A" modified="2020-08-12" version="1">MLLALHRAARTVGFLLAASATVFVNASLTLTLTLCPQANNTSLPCLNDTNQANTTYLARYDATYYNFSNLNISYIQDLPPSARTIDLSYNNIAQISCKIPASLTVLNLSHNALQTNWIQTPLTISSLDISYNEGGLPWIHDVMWGTYLPNLYRLTFRGNNLTTLRLGYDNFPSYSLAFLDLNDNPNVMLSVDSFAYGRLYYGGVSLDLQTSSYNATLATCAGNANFVQSFYSAQTSVGPPKCVYLCYWGYSINTPASYEDPGKQAFHFILVGVGSCAILFVLASLAMRFAVKWQERYVVYLRGTISGSNCSDYDDLPSERGLYVQHPATPRND</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WD57</accession>
    <name>A0A6G0WD57_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="30">Dynein heavy chain 7, axonemal</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">Ae201684_016960</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28 29">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
            <location evidence="1">Flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="28">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000273">
        <property type="protein sequence ID" value="KAF0724295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021504"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000002">
        <property type="entry name" value="Dynein axonemal heavy chain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000004">
        <property type="entry name" value="Dynein axonemal heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000004">
        <property type="entry name" value="Dynein axonemal heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002141">
        <property type="entry name" value="Dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000003">
        <property type="entry name" value="Dynein heavy chain 12, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2620:FF:000002">
        <property type="entry name" value="Dynein heavy chain 2, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1120:FF:000001">
        <property type="entry name" value="dynein heavy chain 2, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000223">
        <property type="entry name" value="Dynein heavy chain 3, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000044">
        <property type="entry name" value="Dynein heavy chain 5, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001328">
        <property type="entry name" value="Dynein heavy chain 6, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000001">
        <property type="entry name" value="dynein heavy chain 7, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.280:FF:000001">
        <property type="entry name" value="dynein heavy chain 7, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.20:FF:000001">
        <property type="entry name" value="dynein heavy chain 7, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000006">
        <property type="entry name" value="Dynein, axonemal, heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000362">
        <property type="entry name" value="Dynein, axonemal, heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041589">
        <property type="entry name" value="DNAH3_AAA_lid_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878:SF70">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 2, AXONEMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17857">
        <property type="entry name" value="AAA_lid_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="12" id="KW-0969">Cilium</keyword>
    <keyword evidence="11 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0243">Dynein</keyword>
    <keyword evidence="9" id="KW-0282">Flagellum</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="13" id="KW-0505">Motor protein</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Dynein heavy chain linker" evidence="19">
        <location>
            <begin position="942"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain hydrolytic ATP-binding dynein motor region" evidence="20">
        <location>
            <begin position="1497"/>
            <end position="1823"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA 5 extension" evidence="24">
        <location>
            <begin position="1999"/>
            <end position="2146"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain 3 AAA+ lid" evidence="25">
        <location>
            <begin position="2366"/>
            <end position="2459"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA module D4" evidence="22">
        <location>
            <begin position="2532"/>
            <end position="2794"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain coiled coil stalk" evidence="21">
        <location>
            <begin position="2809"/>
            <end position="3152"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain ATP-binding dynein motor region" evidence="23">
        <location>
            <begin position="3183"/>
            <end position="3404"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain region D6 P-loop" evidence="18">
        <location>
            <begin position="3650"/>
            <end position="3760"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA lid" evidence="26">
        <location>
            <begin position="3796"/>
            <end position="3934"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain C-terminal" evidence="27">
        <location>
            <begin position="3940"/>
            <end position="4242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="53"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="497"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="3036"/>
            <end position="3073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF03028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF08393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF12774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF12777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF12780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF12781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF17852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF17857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF18198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF18199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="KAF0724295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="30">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="4247" mass="477649" checksum="E312BEDA0D81DF05" modified="2020-08-12" version="1">[encoded data, 4247 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WD98</accession>
    <name>A0A6G0WD98_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phosphatidylinositol N-acetylglucosaminyltransferase subunit C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_016997</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000273">
        <property type="protein sequence ID" value="KAF0724335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WD98"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021469"/>
    <dbReference type="OrthoDB" id="196709at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009450">
        <property type="entry name" value="Plno_GlcNAc_GPI2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12982">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12982:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06432">
        <property type="entry name" value="GPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016104">
        <property type="entry name" value="GPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0724335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="34282" checksum="FB9C790ABC173E70" modified="2020-08-12" version="1">MTKSRRTRQCEHCGREEDGEKKKIWRKILWEQQPFEDCYVDSSFLEQLRTNENVREYDYWGMSKASAAITQQLSLVFIFFAIFVNSREHVWSWHLLAAIDVFVALVGYFVMFYCAQPEFDMWQGVKECMLFSATLSILSPVLRTLTESYAVDTIWALSVALTGIHLITHDYTYINGTTFKYAGTISLNAAIFTSVLLASLLHSNEQVFSFVLFAIEVFAVCPIAQHNIKKTSENAHLALALVLFCTALALMWPISPSISVVVFVAVGFITFVCPLWLMHAQEYKNEIQGPWDIAKVEPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WDH4</accession>
    <name>A0A6G0WDH4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Endo-1,3-beta-glucanase btgC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Laminarinase btgC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ae201684_016899</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation. Active on laminarin and lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000271">
        <property type="protein sequence ID" value="KAF0724419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WDH4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008895"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="beta-trefoil_Ricin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF17">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE BTGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14200">
        <property type="entry name" value="RicinB_lectin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ricin B lectin" evidence="14">
        <location>
            <begin position="284"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="14">
        <location>
            <begin position="458"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF0724419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="645" mass="72754" checksum="61290672C2CBA124" modified="2020-08-12" version="1">MTFVFTFSFASTVSRVMKSVSALVLALTASVTLGLDRWMYGIDYDTRANQWGGCKSANDILLDFKALNSITKHIRLYTTSDGCIDNLLDVAAKENVKLWLGLWCNIEPEKDSFDKEFKTLQRLVKNGQVRNDNVLGIHVASEAMFRYYQNTTWSNRTGINKLIGYLNTTRTYLREHDINIPVTIADVVDTYKAVPELFPAVDVVSINQFSQWEGVHGADGVNVLFDRIKEVYVAARQHGKVLLFSETGWSSAGNVASIKEASPESAARFLHDFMRFTEQQNIAYYYFTSFDLSWGTEGADVVERNFGLFDEHRNLLPQVANTTLGKYHKPVRVWINGQVLKANGYFSDAFGRLYLGPPAVGLSGVLDREIWFWDEDLLTLRSRSTNQCLDTYNDDQGVSRLHVYWCDGTNYNQKWRLKPDGTQQIVSKATAPYADASVDATLGNGTNPLTTDVSVPVGSLFASSRPAHGRCLTAKGTDIAMETCKYTVDQKFTLRPLDTEELYLTAVNTSWRITEDYGKVTVKTTTNDDNADAQIWFYDPLLQRIRNKANGRACLDLVEDKLRGLVQGRWCDHTPSQSWSYNDLTGQVQHLGKIGLCLNVEQEDQELHVVYCDVSSPTQKWTFDLVNRPITDVDTAVHLNALSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WE97</accession>
    <name>A0A6G0WE97_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_016726</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="8"/>
    <dbReference type="EMBL" id="VJMJ01000266">
        <property type="protein sequence ID" value="KAF0724663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WE97"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016411"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000026">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF300">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="9">
        <location>
            <begin position="121"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0724663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="301" mass="34383" checksum="9E1D34C4304A422B" modified="2020-08-12" version="1">MDEDTKWVDAVITKLLRVQDKPVQTEVTDLDIEEINALCRCCRSIFLCQPMLLELNAPINICGDTHGQYSDLLRLFEIGGFPDDKNYLFLGDYVDRAMQSIETICLLFAYKVKYPTRMSLLRGNHECASINRIYGFYDECKRRYNVKLWRTFADCFNCMPVAAVVADKIFCMHGGLSPDLYKMDQIKNIRRPTDIPDEGLLCDLLWADPDAESHGWTESDRGVSYIFGADVVEQFLETHDLDLVCRAHQVVSDGYEFFAGRKLVTIFSAPNYCNEFDNAGGMLIVDEKLTCSFKVLCSQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WEJ8</accession>
    <name>A0A6G0WEJ8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Leucine-rich repeat-containing N-terminal plant-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_016344</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000250">
        <property type="protein sequence ID" value="KAF0725113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WEJ8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020271"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026146738" description="Leucine-rich repeat-containing N-terminal plant-type domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0725113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="341" mass="38367" checksum="F6A4155DB4CB3905" modified="2020-08-12" version="1">MMHPMAFIRLLLAAAASASVAQASFILTLCWNSNNVQVPCLNDTIQGNTTFLSVQKYSSSYNFSNLNISFIQALPPSATSIDLSFNQINAISCPIPNSLNFLNVSHNALLNRWIQTPLTVQTLDVSYNQGGLPWIQNLLWGVYLPKLQHLYFRGNNLAQLSLSYDNFPMYPLNALDLNDNPNLVLTIDSSVYSRLGYGNVKLSLISTSYNATLSICGQNPNYVRPVTSSTPYPVASNGSTSQPIELQTVYVCYRGYYDYSYTYSYQRDRDIIKNVLSVLAASIFGLIVVYRLWRIIITKWQERYQLYSRDTICSSTCSEYNDVPTADHAIYIQQQATPQAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WF94</accession>
    <name>A0A6G0WF94_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_015478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000221">
        <property type="protein sequence ID" value="KAF0726227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WF94"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0726227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="803" mass="90079" checksum="46B84D003C4F0120" modified="2020-08-12" version="1">MMSNMVTLRTLIHLARSSDDVLLHCVLASQPNTFLITSTKNVAHYIQDNTILFTLRATENIVAISSFEGTIVAAGMNGNIWLIPWREIPRKTTINLVNSLKDVSPPKQGNLSRNTPRNSPDEPDYTYSKRKRHRYGGHANVIHSEICIPGIHAIICSLDGFDLTLIALSLLCPSTFVKFSLRTKSSTSRVEYEELEGEKSTSVFYTRSDAVGGIFFSFPDFTRSRYILLQGDADCAVRAATLDCDMHILSQATIFSFRNESIRYIFGLKNSSNLYNSIAIVGEKGRLVVLQGQENSTSSNISMDVQLLSPVDSVQYIETLQSFVYIACGACYIHGFGSSTSVRLPIYQKIKKIVLTDHSQRICCVARSGRVFLVDISSMLCKSYGDDIGRVSSSLQSETYNPEDNTKSALASIRHASENYNEILKTKEDMTCHLKSLLSVLLVSKQSQSNIYCPIQCEGYHICSDQQEVHQLSLQFHGMSTNLFPFNKWYIQVIVRDQVTNHTLQFTFQYPEVLPSFERIMSIDDLGFLTLSTVLEVQCYLVYDEMKSPFHFLLTSRKISIFQFKRPLLTSQRKAEYVDQTSSTRIPPQNKLVKKTSHMWKCYEGYAEFLPTFWSNQTTKSPFLSMTSALIAVLVGHTDENVKSIATKCLDDAGIQSKDKLNQQGFVTAQQPNVSASASQVTYELHQDKLLLQVHVPDISDLALIRAGVISSILTSNLSSILSIEGESDIPSNVASQLSALLVLESKWNDMEHEVKLWTKKGGKSLSSQELLQFVQQIMSCEVDICSVYSKSRHTPNLSTLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WFZ6</accession>
    <name>A0A6G0WFZ6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_016040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000241">
        <property type="protein sequence ID" value="KAF0725477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WFZ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002561"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF98">
        <property type="entry name" value="FI18310P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="6">
        <location>
            <begin position="52"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0725477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="274" mass="29741" checksum="EF299CD702AD9C45" modified="2020-08-12" version="1">MQGLETSLGLSSLDECSMLQIGCPYLIGMVYCIAFVLAVLSTGATSSTHLDIVGGVVVEAAAPAYIATLRADEFQTTICTGILIAPRYILTTAKCTKLSLTWASINSKFRQGRDGEHIRITAINFHPKFKWPELIINTPATLTFDSYEAKTQVVMRGFGQLGYKADFADVLREAKGTIAVNADCNRVYNVDGIFQDDLMCIEGLSPCGGDKGGPLTLLNKEGHEAVVALHSWNALHCDVQYGGFTRLGPSLDFLKSFLQGDDVCKQPVERPSLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WGC0</accession>
    <name>A0A6G0WGC0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA damage-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_015752</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000231">
        <property type="protein sequence ID" value="KAF0725901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019826"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="5">
        <location>
            <begin position="23"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="6">
        <location>
            <begin position="571"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="4">
        <location>
            <begin position="1109"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1060"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1068"/>
            <end position="1082"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0725901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1488" mass="164742" checksum="D6642206CDB42E45" modified="2020-08-12" version="1">MAHSQHFLCHRDLVESSGVLFSLFGPFCSQSSSDLVVVYAQHIDVFRIEMPRGSTTSVSSQNVVLHLLHSFPLAGVVESAQLIYLKKSTACLALTFATAKLVLVRYDNGHLATVAMHNFEEDGMGLGTALQGERFGRTQFSGMSSVPITVADPDHRCLSMLLYQDQLVIVPLQDNRQNDLNDDDEDEAIYQIASLKMEDKTRSEQYASMLASFGMTGIVGRTFLLRLRELDIRGKIIDMAFLEGYLEPTLMLLHEESDRQAVVGRYAAGYDTCCLTVLSINTTTRLHPKIWSIASLPSDCFKIVPCPAPLGGAIVFSQNAIMYLNQNQYFGLSTTAFADKTIDSTKYPLHASPLLPDIKMLLTNCQTCLLTPDEMLLNLGGHLFVLSLPSHRSLKQKGYYGHEVCQLMLRQFAPYKLSASTSMAVDLDRRLLFLGTRDGDSHLFRYSTNNEQHTAELITQESVVVRPVPVPDDMDSDEEDMYLYGRRIISNQVVLTPQVAPDQADVPEHVEFAQYQLELLDILTAIGQVTAMDMGVEMEVEGAAPSEELVLSGGVDEQSSISVIHRGIRPVVITEVPLEGCRAMWAVYGSATAKYHGYLILSMKSKTMVLKAGDDTLPLESSGLFVEGPTLAAANILGNQRIVQVYKQGVRLLEETNDTLGCTQELLLEDAIDCDGLGVDPSVGIVSVDILDPYVILLLSDGSLRLIYADANDLDLSVVQPEIDKTEGILCAVCLFHDWGQLFAPSEDTFAPQAHVFERDDDDVDELYNVSSSSQRKSQASRGLDAQESKGKPVYCAICYDFGTMIVFCLPDFTIQAIFPGLNVAPQVLIDSKLTGQIYPSVGLSQDAKKPSMLSPVADICIHRVGPDDAIGNGNIVSKMVLVVYVANGDLLVYVAEGNKFVRRSTQCITRPFVLKKESSFAQLNTTLFRYPMLTRFHSVMHHSGVFFRGASPMWIWNSRGLAGLTPMAVPLSKKNQVPVLCWTSFHHWNCPQGFVYFHSDGMLRVCEIPSKAKITSSGCVVQKLSMGKTIHHLIHVACHGTGAVQEALQTPTYAVVMSHSSPPPLDDGADNEVEEEAEEDGYTPQKPGEIFEGMERSDFSGLMDEQFELQLIQSVDGQLMREGVFSVQMERYEVVLTIKVMYLSDAPVLVPQEWKQKRKPYIVVGTGVVGQNGEDENGKGRLLVYEVDYAQYTNAQGITGRKLPKLNLIYAKEHKQGGISMVSQLGAYVLAAVGSKLIVYELKGGQLVGCAFFDAQLYIVSLNVIKSFIVYGDLYKSIHLLYWKPQEKTIIMLAKDYEPLSITTTEVSVMGTQLGLIASDMQANIHVMQYEPTHVESRGGQRLLRTSDFHVGARVTSLMRKRVLESPIPLYVTLLATAEGGLGVLIPVQERLFRRLYTLQSIMINALPQNAGLNPREFRQAVHTRSTGRPDAWCTWKAKKAFLDTAVIGRFSDLDYVAQRELARCIGTTPEVVLHNLLELQRTTLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WHD8</accession>
    <name>A0A6G0WHD8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_015207</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBCE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000213">
        <property type="protein sequence ID" value="KAF0726583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WHD8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020955"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17044">
        <property type="entry name" value="Ubl_TBCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044079">
        <property type="entry name" value="Ubl_TBCE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18849:SF0">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 410-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18849">
        <property type="entry name" value="LEUCINE RICH REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14560">
        <property type="entry name" value="Ubiquitin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CAP-Gly" evidence="8">
        <location>
            <begin position="30"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0726583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="518" mass="57267" checksum="631318CA9DF4AB97" modified="2020-08-12" version="1">MMNKRVQDGDGFRGTVRYEGPIHSKNQAQVYWGVEWDEPSRGKHDGATDGVRYFQTSRPSSGSFVVPDKVTLGRGILDALRERYMQNEHEDTLVAGKVATAGGNTKNIQLVGVQKIQGKQDLGVISKVSLEACKVAYIGNHGELLEAAPHIVELNLGFNLLSSWSEVLKLSSELPELEHLILSGNVLEYDVTESNPPAFSNVQVLVMNQTGMSWANILHICRAHFPAIRELYISSNGITDEMLHSTPSELLSPALEWIDLSHNQITDWTAISTALGGLPNLQQLALNGNQLAKLDARDMAGKFPALSTLSLSDNLIAGWSSIDALNALPALQFLRMTKNPLLNDMGAGESRMLIIARCQSLVAFNSSEIRAKERQDAEQIYLKRILHELVCFPEAERSKVIASHPRYTQLTAMYPEIQAPNSKDASGPSALARSLVRVTFIPMTMNATTMDEMEKKLPLTMKVSQVKLLVQKKYGLEEHNLSFLASKKSMPIPLDDDNEELSYYGIQDGGDLLINEAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WHG8</accession>
    <name>A0A6G0WHG8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytosol aminopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_015220</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Release of N-terminal proline from a peptide.</text>
            <dbReference type="EC" id="3.4.11.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.</text>
            <dbReference type="EC" id="3.4.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000213">
        <property type="protein sequence ID" value="KAF0726598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WHG8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007548"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00433">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00181">
        <property type="entry name" value="Cytosol_peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023042">
        <property type="entry name" value="Peptidase_M17_leu_NH2_pept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008283">
        <property type="entry name" value="Peptidase_M17_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963:SF23">
        <property type="entry name" value="CYTOSOL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="LEUCINE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02789">
        <property type="entry name" value="Peptidase_M17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00631">
        <property type="entry name" value="CYTOSOL_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytosol aminopeptidase" evidence="7">
        <location>
            <begin position="347"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0726598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="505" mass="54192" checksum="F9ADAE575B427288" modified="2020-08-12" version="1">MHRLQQKVVGKVKLLGKAESVPTSAAKLAQVVFVPKTNKTQALQQALPFPVSEHVLDDFNANAKESIMLYPKDNARTLLVGLGDSVDEVSLRDATHEALAQLTSRGIQQALLEAPSVDTVPAQRVAEVMAETSVLSNYRFDRHLSPPKDEKEPVKQPLSDIFVRASAEFDQIVAEKLAVAEETILARNLGNERSDVVDPAFVEAVAKESASLPNMRVSVLQEADLRAEGMHMMALVGQAATCPPRLVVLEYTGAPSNASKRIALVGKGITFDTGGLNLKPTGFIEDMHTDMCGSAAVLGAIRAASKMQLECNIVAVLALAENAIGSKAAKPHTIVKSLKGLSVEVNNTDAEGRLVLGDALTYVQKHYAPHTVIDAATLTGACMVALGEYCAGLFSNSDDLAASLQQSGQTTHERCWRLPILPEHTAELKGYQSDSRSTGKTRYGGACTAAAFLQQFIEKDVKWAHVDIAGPSNYSSAKSYMPQGATGFGVQLLYDFIKKTEHASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJT4</accession>
    <name>A0A6G0WJT4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_014347</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000193">
        <property type="protein sequence ID" value="KAF0727517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJT4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006306"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF440">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0727517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="22812" checksum="8D53CA1237D83990" modified="2020-08-12" version="1">MIGAKRLLRYIKSTPDVGLTFCRNKMTLMGYSDASWASRPDRKSVTGNLCLLAGSVVSWKSARQRIVALSTCEAEYIALAEVAKEIMWLRGLLNDIGILQTDATPTFCDNKAAIATAENDNISERSKHMDVRMHFIRQLLKEHTLVLKHVGMVDQLADVLTKVSTRAALESFRNLVMSPTKDTPSTQLPMEIPQSAKEFAPVSESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WK10</accession>
    <name>A0A6G0WK10_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA (guanosine(18)-2'-O)-methyltransferase TARBP1</fullName>
            <ecNumber evidence="8">2.1.1.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">TAR RNA-binding protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_014408</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 18 (Gm18) in a subset of tRNA. Selectively mediates Gm18 methylation of tRNAGln-TTG/CTG and tRNASer-TGA/GCT. Gm18 modification can enhance the stability of modified tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>guanosine(18) in tRNA + S-adenosyl-L-methionine = 2'-O-methylguanosine(18) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20077"/>
            <dbReference type="Rhea" id="RHEA-COMP:10190"/>
            <dbReference type="Rhea" id="RHEA-COMP:10192"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74445"/>
            <dbReference type="EC" id="2.1.1.34"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:20078"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.34" evidence="8"/>
    <dbReference type="EMBL" id="VJMJ01000193">
        <property type="protein sequence ID" value="KAF0727581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009746"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141100">
        <property type="term" value="F:tRNA (guanine(18)-2'-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18091">
        <property type="entry name" value="SpoU-like_TRM3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1280.10:FF:000010">
        <property type="entry name" value="probable methyltransferase TARBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045330">
        <property type="entry name" value="TRM3/TARBP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044748">
        <property type="entry name" value="Trm3/TARBP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12029:SF11">
        <property type="entry name" value="METHYLTRANSFERASE TARBP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12029">
        <property type="entry name" value="RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="tRNA/rRNA methyltransferase SpoU type" evidence="11">
        <location>
            <begin position="1283"/>
            <end position="1425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00093266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00093594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00093656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0727581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1436" mass="161929" checksum="1C487E71CDB11A5D" modified="2020-08-12" version="1">MSSSSTDWEARVRAAHAVYSRWRETYNTEDLELLSLGFVSSLNRDQVVQMCEDGSLLTIVQDKTQDDVTYLRFAFAVVRQCLGVAKQQTAAMQATLDTLITSACLPLLHDDCSASLGEIVLDVLLNALEAIPSEDSSWWDQLHARLLTEFTAPPQNPSWLGLVVEFLFKHKRVSSAFVDKITSICASMVASSDAVSLRQAIFGAVVPQLIQYDSTQAQVLFDIVLKTWKANALQHICLILCELLPHCPLVHRESGFHSIVRLGLQQDEAVVRKMALHLLSLSLAREPKAHPSWASFVHAFEIVHFHHEQHLMEQVWPSIATLVKDTIVVPKVSQPLDYSLFDLPLPFEWFQGIVQRCWHHDNPVVRRMTLTEFMIVGDAEWKDHPEIQPGTVRFVLDVLLPSLNDPFLFKHEKYNVRSATVSFTTRFVTLAVKANLITLVEYLDAVQAAIFGDQTRGNSPDALLALLSIFTDLPSSFSIAPEGLDVLRYMVQAHVLQSFPKTMKVLVPILERVLFVYTSAESLPLEVVARYLLLFPLEHLQHRRSAFAKFLTQLHTPIYDGLALYFTEPAKAMGTAALTRLILCSTVDDIPWPATMTSHFVEVSQLFEKLHRASLTTITAQLPATYFDHGFDILKKWLQEDQSGSDESLDSDAQLAVVYLLTQIALDAMQTLGDCEPAHRLNSELVLALNSLVQESSSSQQATLVVQTLDVIATEAPFLMDSITVFDPQVLVPQLLLFSLVKGNDKRDSTLARQFVKAKYSVLAAVLTSCWSLSPELLQRVLDEVVDALPTAGNDPLVLEHMVHVLRIVLPFTAGKDDDDSRLDDIFDQVWASYSDSRKPDSLTNAVIQCLFQPQLMSFTETLKRWFTKWTRFGEGGRRPNVMFHLATTLCGIWRQYPTRAIAFVDEIITLLLYKEPTVDVKEQMIYLSDGAALKERYVRFVVLAFLEDAPVACHPLMDALIVALLHLQLQPEFMKPQMINSDGFGRQLRSWQALCVLSKYVQAHNVDSIHEILWHRAFLNHNLPQIRYFIEIFAMRVALAFPISSFPYLQQLLKDMHMMPQLSASLLLVTSVVLRRLPVDETPQLHLDTLLLMVPWLNSTHGHTRTIVQFAVVTLLPYFMTRSAYASTVAFLEPTLRYLTSNKDCKRMFRRQTDQMASFVPEKECSLAGLLGGTLNEFDEIVPVSIVEQVKEALSASFAQFLKEDRRHGGQYQSNVADSLKLSAQSVEDLPDIEATSNNASIVQRKIDPNAVVFLEQLLAQHEAESLREKQMNARRQRHQPVIVCASLVEKIPNVAGLARTCEIFNASKLLVPSMTMIDDVIFRQISVTANKWVDMEEVRSEDVRAYLRRIKLLGYTVVALEQTSSSACLSTFEFPDKCVIVLGNEKEGIPVDILQMVDLCVEIPQMGVIRSLNVHVSGAILLWSYTQQRLLQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WKC1</accession>
    <name>A0A6G0WKC1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_014339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000191">
        <property type="protein sequence ID" value="KAF0727715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WKC1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007641"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007965"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="515"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0727715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="688" mass="79410" checksum="0CA5CC967A4FABE4" modified="2020-08-12" version="1">MEDSSTDSQDAVKPLGLSLTYFKRFIDIHGGRSAFDGLSTGAVCRQFLLPYTATTKLSLVEHVRQLPDGHLYAKPATWFVSHAWSYLFLDVVDALTDFFQENDLDESLAVWFCTFCNNQHAIQDQIYDFEHWFVIFRSSLRAIGNVVMVMSPWNDPVTLKRTWCVFEVYASVVENACFEIAMGRSQKASLIQDIQSNGAFREMLSKVKSEKSEAKVASDRDNIFELIRDEVGFTQLDRMVFGVVEKWMFRSVDHEIDAAPTTEIQVEWIMVKGNLLYDKGEYAQAADAFQTAHEIYRRDFGEDCPETWQALAQWGRSKWSLGHPLDEIEAMYDEVLRHQLRLLSKDHKDTLTSMTNLGAIYSRQGKYDVALPLLMECYERRRHVLGEEHQAVRNTMTEISIALDHLHRVDESLEWSRRCFELQMRVCGADHPDTSRMQNNLAISYLLLGNVASALPHMKASYESLSRTLGQDHLITLMIYANLGNTYRLVGDYATAERFLLDCLERQESERYDKFTCMRYLGLLYLSTHELDKAMTYYKEALAIVAAMHGRTHPIYARSLPPMFTIKMEMGCFNHLEEIAAFERELVDTQWTQDSWKDSMACHGCRREIHGKLFACSQCPPHALRFCHACAELNKPAAYCKHGADAIESTKPPQRYLHEQRLNILAKNSNWVEYEQQYAIYRSYCDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WLH3</accession>
    <name>A0A6G0WLH3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UBL3-like ubiquitin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_013951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000181">
        <property type="protein sequence ID" value="KAF0728125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WLH3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018788"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039540">
        <property type="entry name" value="UBL3-like_ubiquitin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13881">
        <property type="entry name" value="Rad60-SLD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBL3-like ubiquitin" evidence="1">
        <location>
            <begin position="3"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0728125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="120" mass="13051" checksum="17583F5B8A1F4613" modified="2020-08-12" version="1">MEPIQLRFLFANKEGVKIIVSTTRDKYVSDVKRQLLEFWPADVPKPDSLVSIRLICMGLGMLQDTKTLAESKVPVLPVHPTPINVSLLPPKSESQALLVDQKAAAGGASAAHPSCWCTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WN71</accession>
    <name>A0A6G0WN71_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RxLR effector protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_013361</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000172">
        <property type="protein sequence ID" value="KAF0728789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WN71"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021803"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026173526" description="RxLR effector protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0728789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="26260" checksum="963CA629CE0D22BA" modified="2020-08-12" version="1">MRVLALSCLAIAASASAQADLNTAVKRNLRARTQDELNDAFVQRENRYLHNIESDIEPIAIAVGGNPNTWGTNPLTRERKPGRVHLAVMDPAELGKGIEGDVAAKSDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WNH4</accession>
    <name>A0A6G0WNH4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Multidrug and toxin extrusion protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_013443</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000172">
        <property type="protein sequence ID" value="KAF0728874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WNH4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010766"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13132">
        <property type="entry name" value="MATE_eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045069">
        <property type="entry name" value="MATE_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0728874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="491" mass="53240" checksum="D57825ED65C6246F" modified="2020-08-12" version="1">MASRSRSNSANEANPLLAKGYSPKPSQSGLESAKLDVHANASQETVELLKLAFPIVATLMLEFLPGAFSVALVGHIDSPMRKEFVDAAALASVFLSITGLSIGSGLSTAMDTLCSQTVGAGKLYNLGMYFQSGLIVLGSMYIPSLILNFNSEFFLVALGQDATVAELAGSFSKITVFALPGIFLYELLKKVLQAQKIVSPMAYIAVLTNFIYFGLGYYFCFLGAAYARTISQLLLPVFGFSYLLWNPVYKEWWPADHSFSAQWKSAWGHVPEFFALGIPGMLMMIMEWWAFEICQLMAGWMPNPVLSISVQSVLMSLSAQAYSLFLGLSIATTVRLGNALGANEPNRAKIISKVSLGVTFCAGLFVSLVFLLAHNALPQIFISDPASIEATQRVLAIFVVFELIDGMSCSAQSLLKGMGKQSVGAWVNAGAYYLFGIPTGALLVFVFHFGIEGFWIGLAMGLFGGFCVYIWFVSRVSWKQMAIEAISRTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WP87</accession>
    <name>A0A6G0WP87_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">AP2/ERF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_013156</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Iojap/RsfS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000167">
        <property type="protein sequence ID" value="KAF0729179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WP87"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013540"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090071">
        <property type="term" value="P:negative regulation of ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.730.10">
        <property type="entry name" value="AP2/ERF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01477">
        <property type="entry name" value="Iojap_RsfS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001471">
        <property type="entry name" value="AP2/ERF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036955">
        <property type="entry name" value="AP2/ERF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004394">
        <property type="entry name" value="Iojap/RsfS/C7orf30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00090">
        <property type="entry name" value="rsfS_iojap_ybeB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21043">
        <property type="entry name" value="IOJAP SUPERFAMILY ORTHOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21043:SF0">
        <property type="entry name" value="MITOCHONDRIAL ASSEMBLY OF RIBOSOMAL LARGE SUBUNIT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02410">
        <property type="entry name" value="RsfS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51032">
        <property type="entry name" value="AP2_ERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="8">
        <location>
            <begin position="85"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0729179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="335" mass="38137" checksum="31F4A6CE41E322E2" modified="2020-08-12" version="1">MLSRSFKHLAAKARQAPSKRLFSALTRSSTARNALTYRPAFMALRVSSFHQSHCVLDETKDKDPTASVEESDDDLDGDDGTPSEHYLGVTYHADRIKKWSASVTVGQIEVDAGQFWTEEDAAKGYDELVRMYLEPGAPINFPDGEPNDDDESGNLEVGGIDGSHEWTLPDAGSRHADIIPPIPNTYLTMEELIPALEREQAIDIYTIDLEGKSSLASYMVFCTGRSRNHMRRMADMVILSMKARNMQDDFGYVVEGRDSDDWMIADVNNIVVHFLTAETRQMLQLEDHWENMVNDKHKLYGHLSEDEYMDKYGMSELMTEDDFLHEDEIDHNEWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WPI9</accession>
    <name>A0A6G0WPI9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_013052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000166">
        <property type="protein sequence ID" value="KAF0729306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WPI9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018382"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0729306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="139" mass="16199" checksum="C04747C18528D7A6" modified="2020-08-12" version="1">MALENHLEQNNRLNPSPKVEWPKPAYRGKCKYKGGRCPNERTLRYTGDIHTLCEEHRLRQNRIQSKSDTKMRRFKRLLAMRNKGSEDDHTTTPIKTELSPPHIDDVLPLVPTPEVPQEEIVNALCPEEMHIFIEMMGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WPU6</accession>
    <name>A0A6G0WPU6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_012890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000164">
        <property type="protein sequence ID" value="KAF0729388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WPU6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008061"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="26"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0729388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="547" mass="63435" checksum="5AE420AD97238555" modified="2020-08-12" version="1">MKELSPHEVKKWEAAMDKEYNSLLENGTWILVERPNDRVVINNKWLYKIKRDREGNLRYKARLVIKGYEQIEGMDFDETFAPVVRFETLRFILLYSAMREWKLRQYDFVTAFLNADMDDFDVYMEQPRGRVIKGNEQMVCLLQKSLYGLHQAPREWNSLLHCYLLTLGFERCEKDYGLYVKWVEENSMNDVIYLTIYVDDLVLLGEDELVYPIECLLTTKFKITQMGDLRYLLGIEIDNIPGEWLIFSQANFIRDIIRKFGNLNMNPIDTPQGKEKDPPGRGQEDDFVAEAYPYRSIVGCLQYLVTGSRLELANVVRTLAKYLNNYTMAHWKLAIRVLKYLVGTVNHGLAFDIKEALKYDGLCVETWVDSDWANDETDRKPITGYVTKVNGCTISPKSEKQDIIATSTCHAETIAASTAARDIRWIEQLMDECYLSHAPSSLIIDNHGAERLCNHPGNHKRTKHIEVRHLYVRECVEKYGLKTFIVASDSNLADMNTKGLSRERFLEMKTEIGIVDTKSILDLDCQQPRQPNIDESRKAITFPQHGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WPV4</accession>
    <name>A0A6G0WPV4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_012911</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000164">
        <property type="protein sequence ID" value="KAF0729410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WPV4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014445"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019162"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="32"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0729410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="291" mass="34061" checksum="71640255C174CEC9" modified="2020-08-12" version="1">MEPPRLPTAVEARRLAETLRKRKYRAVQHNELVQLKAQAWRLEGYLARLKREETRQVEHAKDENASLQTQVNQCRDLIKLLLQWVRINEQPQKDLSHRSTWYESFRLPTRSYQSITNMARGLQREGDKPISNVCSPLKQPIVERDHSNCTFVWTYQNALSPELQSIYPSMGAKFSPTHVFCAIHPHNHGRVATKIHQVCRYPTKPKRIFEPVRRRKYRAKKLNELFELEAQARSLGAHLAWMQSLARARQFAEADIKAIRSQVSQFQDLLKTLTDWAQIILYPENCPPYVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WR95</accession>
    <name>A0A6G0WR95_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sidoreflexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_012587</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sideroflexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000159">
        <property type="protein sequence ID" value="KAF0729948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WR95"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009828"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015075">
        <property type="term" value="F:monoatomic ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990542">
        <property type="term" value="P:mitochondrial transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004686">
        <property type="entry name" value="Mtc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153">
        <property type="entry name" value="SIDEROFLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153:SF37">
        <property type="entry name" value="SIDOREFLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03820">
        <property type="entry name" value="SFXNs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0729948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="35313" checksum="14C49182FF5245AF" modified="2020-08-12" version="1">MTDTSTKPKFLADPDEATYWQRVKKTWEMLDFRTAFATAEQVQEAKSVVWSAKNGAPIVDESTYQDALHLTRAILHPDTGETVFFPLRVSMIVPMNLGLDCGMILASTTKSTIFWQWLNQTYNALHYYANRNATNEDTTNQRIAAYIGATASSVAASLGVRKWAKAHHNPLMMRMAPFAAVASADLLNLAIMRQSEYLRGVNIYDEEGEWIGTSKACGLYAVASCIGGRIFAAAPILICPPLIVQQLEKTVRFQSRPWLKLPTTLALVGLFIQGSVPLTFGLFRQSAQVDVTHIESEFQSLVRSNGQPVRTVTYNKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WRI8</accession>
    <name>A0A6G0WRI8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Inhibitor of growth protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ae201684_012379</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of an histone acetyltransferase complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The PHD-type zinc finger mediates the binding to H3K4me3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ING family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000156">
        <property type="protein sequence ID" value="KAF0730083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WRI8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003326"/>
    <dbReference type="OrthoDB" id="5411773at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16857">
        <property type="entry name" value="ING_ING1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15587">
        <property type="entry name" value="PHD_Yng1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000016">
        <property type="entry name" value="Inhibitor of growth protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF42">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="13">
        <location>
            <begin position="231"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF0730083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="283" mass="31643" checksum="7F15A44481143030" modified="2020-08-12" version="1">MGTYLEDYLESIYMLPSEVKRNFELMRELDKATSGLLDDLRESQSKYLKDARERIRKRCADTNAPEPTEEELRALVGEDNEDETNPSPDNPLAYLKSKRHLVIQKMDEKVAIASQSYDLIDHHIRRLDNDLANYTALLKANGEYEDEKIVVKKQKDVVPDTKATGAAAAAIATTTPNAASHKKSAAGLASSHKKSGRKRNAADAQLDAIPEAVAVSQPLTLEDLPIDPNEPLYCHCRRISYGQMIGCDNEDCKYEWFHFDCVGLTEQPSGAWYCKDCTAEMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WRP3</accession>
    <name>A0A6G0WRP3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_012410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000156">
        <property type="protein sequence ID" value="KAF0730115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WRP3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012231"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0730115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="101" mass="11740" checksum="21C01BA89C538D4E" modified="2020-08-12" version="1">MRLQQESSSRASSLHAELPCVDILHMFQLLKQRRNVIQEKRALIFQSNMDDQTAQVDNNSTPRMLKRKADVEDPVWTIKQAKKEEFSRLFSDNVVPSPLVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WS27</accession>
    <name>A0A6G0WS27_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein mS38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_012233</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mitochondrion-specific ribosomal protein mS38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000155">
        <property type="protein sequence ID" value="KAF0730230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WS27"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003577"/>
    <dbReference type="OrthoDB" id="74354at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013177">
        <property type="entry name" value="Ribosomal_mS38_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32035">
        <property type="entry name" value="AURORA KINASE A-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32035:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08213">
        <property type="entry name" value="COX24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01155">
        <property type="entry name" value="DUF1713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein mS38 C-terminal" evidence="6">
        <location>
            <begin position="98"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0730230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="129" mass="14603" checksum="35F0E1549E4F8AA5" modified="2020-08-12" version="1">MSVLRVVSQSLGRLSHAPVKPAFALQPRFLSGVHRVRMDVSHMWNVGSFPVVDKKASSTGSVFDTTGMLSSLPDPFPMFGYPTAPQLIGDMAQDVEYRADSVLRKRRKKMNKHKHKKRKKALRNRTKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WSL6</accession>
    <name>A0A6G0WSL6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_012127</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000154">
        <property type="protein sequence ID" value="KAF0730426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WSL6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015961"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="222"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0730426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="525" mass="59495" checksum="05157E8777815D2D" modified="2020-08-12" version="1">MSSATKPGSEDDETDAPGPVLSPPPAPQSMQAYWTTRLAQMKNSAAAAKKHWAPQLQQLQSRITSTTSAASIAAKTSRERLRAKSMTEQLQPTIDRAKVGMNVLKRRVTHTSARVQRQMGKLGTRLANELFVDKKFRKIMQGDTLPTRFLQEASHDHIVYSMDVNPASLAETCFGIPFVLYSILSFAGCVPTIAQMAAVNVSIRQLVLAEPRLVRFCVRYGTFTPRLRLGFWLHVSGASSLQASSDFDYATYVCLAKSNHEWTDAIWVDVRRTYIRVAPHLRNGNPWHDAVDSDADIQEQMSNVLHALAGRFPEVGYCQGMDYITAHVLEHVKAADASYAHIHGETKHRVMVAQEETTFWLMASLFESYGLRDMFSPGLGKLHLHCYQFNRLFQLGLPTLYDHFHTETIMVEMYLVGWFQTLFLYLNALPKSSLDAIWDVFFFEKSWKVLFRVALAMLQASESHLLQQPIDHVMRFLNTFATHQHVLAATPLREAALRIKITNSMLTRLEKDHAAKQRRKPSPIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WSX1</accession>
    <name>A0A6G0WSX1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_011985</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="VJMJ01000153">
        <property type="protein sequence ID" value="KAF0730563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WSX1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004448"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00268">
        <property type="entry name" value="DEADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12937">
        <property type="entry name" value="GUCT_RH7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059027">
        <property type="entry name" value="DD_DDX21-DDX50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044742">
        <property type="entry name" value="DEAD/DEAH_RhlB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050547">
        <property type="entry name" value="DEAD_box_RNA_helicases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012562">
        <property type="entry name" value="GUCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47963:SF8">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47963">
        <property type="entry name" value="DEAD-BOX ATP-DEPENDENT RNA HELICASE 47, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26142">
        <property type="entry name" value="DD_DDX21-DDX50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08152">
        <property type="entry name" value="GUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="134"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="347"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="653"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0730563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="687" mass="75353" checksum="D1636561616EAA92" modified="2020-08-12" version="1">MSTDTHKTMKKEKKEKIKKEKKDKSEKDVIAEEEAGEEKPVKQEKIKKEKKEKKAKKRSRDEDEEDTDAPAASPTTTVESEEEPPAPKKSKVHNVSTIGDDNPPLSSFRISNETIANLEKRGINQLFPIQAMTFDKIYDKKDLIGRARTGMGKTLAFVLPVVELLLKEGIRRGRGRPPKVICMAPTRELAKQVAQEFELTGPSLTTTCIYGGASYQSQNNDFSKGVDIVVGTTGRICDHLDRGTLRLHQCSFFILDEADTMLEMGFREDIQKVFQAMQAAKTSEHSIQTLLFSATIPAWVESVAKEYMSASREYVNLVKDNEAQASTDVEHIAIPCHWQTRPQLLANLLSMYTTKSSRTIIFAETKKDCNELAVNPDIKQDAQVLHGDIAQGQRETTMQAFREGKLRLLIATDVAARGLDMDVDLVINSEPPRKQSGRADVETYVHRSGRTGRAGKKGICITLFTPKQKDNLILIERHIKKKFTMKSAPNVDDMITQSAATASAELETVHEDMLGLFLPTAEALIEKHGAATALASALACITGYTRPVAQASLLSGAPDMITVMFESSNPIRAKGYVWNAVNRDIPEQYAAGIKNMQLTKDGMAACFELPVAGLSVIEELIKKPDSSYPCPYSIPKQLPSMAEVPVRANNGGGGYSNGYSGGRGGGRGGGRGAGRGRGSGGRGGRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WU11</accession>
    <name>A0A6G0WU11_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_011559</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000147">
        <property type="protein sequence ID" value="KAF0731007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WU11"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014541"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006447">
        <property type="entry name" value="Myb_dom_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01557">
        <property type="entry name" value="myb_SHAQKYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12802:SF155">
        <property type="entry name" value="DEUBIQUITINASE MYSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12802">
        <property type="entry name" value="SWI/SNF COMPLEX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH myb-type" evidence="8">
        <location>
            <begin position="38"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="38"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="7">
        <location>
            <begin position="41"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0731007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="152" mass="16972" checksum="D9707A9158F08670" modified="2020-08-12" version="1">MPSEARSSHFQICALIAVCRPMLNLSPRSFTSDLDDAKPTEGKGTWTKEEHDRFLQAIELYPSGPWKSIAAVVGTRTIRQTQTHAQKYREKIARRNRGLRAKSSDDLAESQLTEGQAWATSSGAPSSPDDMLFLESMEFIVDFLNSIETPIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WVZ2</accession>
    <name>A0A6G0WVZ2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor 38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_011002</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PRP38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000140">
        <property type="protein sequence ID" value="KAF0731698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WVZ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003548"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005037">
        <property type="entry name" value="PRP38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23142">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03371">
        <property type="entry name" value="PRP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="287"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="295"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0731698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="478" mass="56133" checksum="BA04BD5A18EC7891" modified="2020-08-12" version="1">MSRSALSRHEFQQAMANRMNAPAYYAAVSVPTASAGVYSEEEARQIKENELPLHGNLTTYNINKLLFDNIMNSDYFRKLYELKTYHEVVDEIYYRVDHAEPWAAGTSRIPSTCFCLLLKFCTMRLAVKQMQGLLKHVDSPYIRCVGFLYLRYTCDPEKLWEWYAPYLDDEEEFNASANDKILTTMGAWVRTLLEDVNYFNTILPRIPKKIQDGIKIKLLLHEQRKKREKENQDIVDLLVKGTKVRALYADEENAPAMYDAVIDEVDPTDQTYWVSFPEYGNTEKISLGDIEFDRPKKKSPSRSRSRDRSHHRSRSRDHPRSRHRRSSHRSSSRDRSRDLSRDRSRDRSRDRRRHRRSPSPDRSSRRRSRSRDRKKESSLAEDLMAQVREKERRKAEAVGKDYAARPASYKGAMSLKQDRFTTRKRSRSPVKRDVEFVELEKPKETTAPRMSWEAEERRRKLVEVYGDAGAKSKPKTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WWW4</accession>
    <name>A0A6G0WWW4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_010932</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000138">
        <property type="protein sequence ID" value="KAF0731982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WWW4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009323"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0731982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="495" mass="56601" checksum="8946F13388D14878" modified="2020-08-12" version="1">MSRDLARIDRKRDVNIEKMRDFRRNGYDEHEMSDSMDNGYNYSNNGYSPYSQAYGYGPDPNLVNSALTTRNYYPEHDEQYLQHPSHPHLGYIEADDVQFEQSYAYQPERYPSHLRHTGIRTSRASFTYYAQSSDSNEIVSTVPSTRGDRNNVRPRQQRRKALRFRDPLTEEFQTETYFQTPSRPLMYASGASFRLYHPEELPCPVLDQLPRSDAVTKHLRNCMLLSGELGVTTRWTLMPTTRFTVCELYPNEMVILREKTKMRMQEQVALTGIMVEILSPVSMSLRVAHTQKEMVRLSVRDGQEALLQEWYWMLQVAMAMKVDVSDAGGNTAVKKKESKTRSVWVVRSVDEDDALYSTRVARYIANALAGAEVQVLHNGEAGSRALAERINEQVNGRTLRESVFLGRYVLGDDQAASRDARRKLAYDMFVQRGRIKRLVLVVEEELLAVMVARTQATTEDEFGSGFGTSMLDVCNGVEFAVDMKTGETKIVSAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WX24</accession>
    <name>A0A6G0WX24_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative auto-transporter adhesin head GIN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_010706</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000137">
        <property type="protein sequence ID" value="KAF0732053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WX24"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015187"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.120">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021255">
        <property type="entry name" value="DUF2807"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39200:SF1">
        <property type="entry name" value="AUTO-TRANSPORTER ADHESIN HEAD GIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39200">
        <property type="entry name" value="HYPOTHETICAL EXPORTED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10988">
        <property type="entry name" value="DUF2807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Putative auto-transporter adhesin head GIN" evidence="2">
        <location>
            <begin position="219"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0732053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="404" mass="42435" checksum="1DA10D6BB5F43744" modified="2020-08-12" version="1">MTSSAPFTTTWTSGSDAFDRLYIGVPGLAFVKYNASLVDAATVVLTSSSKEILDAIVTEVVDTGRNIFGGAGHITYISTASELKMHFAEDIQLDAHGTLLVEVTLNAPINAITSIADTVIEEGALPLASDADIDVTSVGHNNIWIDSTDASVAKLSLTVSGAGNTYLKASTLHVADVARFNIMGAGSVVVEAAEVSANAIESNVFGRGSVAVHGNTVANSLQTNLMGSGFVSYYPSGSCQTSSVQIGGQGNAYLASVVCDATSVNIMGHGDAYVQTVDTLKRSGMGSGSIKYFNTTPAHLPDEHPHRFFRQPKVELTTDNKFKPAVIATEPTVHDAKSIDLHLTVGKFSWLHTPPPETLSAQAAPDGFFDASYGLAVVAMLIVSLIAFVAFKKTTKRVAYEALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WXB0</accession>
    <name>A0A6G0WXB0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_010821</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000137">
        <property type="protein sequence ID" value="KAF0732172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WXB0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002018"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF214">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="364"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="316"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0732172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="631" mass="69407" checksum="85FC03BB1E699E9F" modified="2020-08-12" version="1">MSESKWKESSNLVARFKEMYTANPKASNVSYEGITLPTAVTSRLADKGLAFDNLPNLMRQALLWDMGLVVGHVNGDDTLMQVYVSVNGSMANIMLPWNDFIKSTAGADPVTLVPKEQTTCTFGGVAYNRQKVMDGLALMKTLKCAVSLVGIDGQSTLIAQDALPSTVVPQPRLYKHQDTTQGWTLLGIHLLPTTSSAASGEAAWGECPADASHEALIIPCEVKDYLSTSTNKYMPRYSSAMDSWLAEFKAANPNLTIKPSTTSISPTPVPTSTPNTSNVGLIVGVACGAVALIGLLLLWLLRRRRKQPLAYEDTREDGYAPATTQKHQGTGTFGTSSSQFGRHTGSEGISLASISLYRLQNEDVKIERLIGSGAYANVLLGSYKGRDIAVKQLLPGRASIVEVQALVDEIVLLAGFSSPYIIEFVGAMWDKPIDLACVLEYMDLGDLRHYLSHRPSSEYSWSEKIECIYNIIEGLVYLHSFPIIHRDLKSRNVLLDTHKGTKLTDFGVSREQTQETMTNGVGTYRWMAPEILKYNHYTVAADVYSFGMILSEFATHEIPYADRVNPYDGKPLIDTAIMAMVVTNEIQPTFTNDMPAFLKDIALQCISHDPSKRPTSMVLSSKIRKHMTMTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WY17</accession>
    <name>A0A6G0WY17_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_010506</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000134">
        <property type="protein sequence ID" value="KAF0732397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WY17"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020699"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026016591" description="Amino acid transporter transmembrane domain-containing protein" evidence="2">
        <location>
            <begin position="28"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0732397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="79" mass="8590" checksum="CA371D260A0ACDCF" modified="2020-08-12" version="1">MTFVIAYVMRLLSLVTLVLLPPQKPQAQALKREGGKQPWMAVLTLVVMACSLLYGVVTNLLTIFPETACLRLAGGRGCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WZ78</accession>
    <name>A0A6G0WZ78_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Neutral ceramidase</fullName>
            <ecNumber evidence="5">3.5.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_010195</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an N-acylsphing-4-enine + H2O = sphing-4-enine + a fatty acid</text>
            <dbReference type="Rhea" id="RHEA:20856"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:57756"/>
            <dbReference type="EC" id="3.5.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the neutral ceramidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.23" evidence="5"/>
    <dbReference type="EMBL" id="VJMJ01000128">
        <property type="protein sequence ID" value="KAF0732871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WZ78"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008065"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017040">
        <property type="term" value="F:N-acylsphingosine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046514">
        <property type="term" value="P:ceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042759">
        <property type="term" value="P:long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2300">
        <property type="entry name" value="Neutral/alkaline non-lysosomal ceramidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006823">
        <property type="entry name" value="Ceramidase_alk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038445">
        <property type="entry name" value="NCDase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031331">
        <property type="entry name" value="NEUT/ALK_ceramidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031329">
        <property type="entry name" value="NEUT/ALK_ceramidase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670">
        <property type="entry name" value="CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670:SF1">
        <property type="entry name" value="NEUTRAL CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04734">
        <property type="entry name" value="Ceramidase_alk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17048">
        <property type="entry name" value="Ceramidse_alk_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Neutral/alkaline non-lysosomal ceramidase N-terminal" evidence="7">
        <location>
            <begin position="119"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="Neutral/alkaline non-lysosomal ceramidase C-terminal" evidence="8">
        <location>
            <begin position="602"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="533"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="569"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606823-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606823-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0732871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="766" mass="83951" checksum="89BBE414A4DC0BD5" modified="2020-08-12" version="1">MTVVGRLAEENDRLQRQASLSQHISRGIFPSMNSLIEWIRSPHRSLAFAIFFKDDMTQDGLELAGDWKVWDNCTTKYRPSTRSSILQFAQSRRSSAMRAICTACTLLALFLHVVCGQNYRIGVGKADITGPAAEVVMMGYADTSQKSAGLLNRQYARAFVVQDDATNSRVLLVNCDVLAIFQLVHQEVVKQLAAKYGTLYTEQNVILHAIHTHATPGGSSAYFMYDVSILGYIDETFQAIVNGILKAVDQAHNSVAPGTIRFNKGKIPDGGRNRSPPAYEANPADERAQYEDNRDYDMRLLQFLDSTGGLRGVWAFYPVHPTSLTQKNYLISGDNKGYAMFTVETHFNDKVVVALGISNAADVSPNRIDNGNGTFSGEGLNDIQSAEIIGTRQANKILELLSSPSEQITGSIVGKLSYVDFSNVTLKGVQPTPEDPYAHRTCPALLGQNFAAGTEDGRALSEFTEGNLKANPLFQALAFVIKPTPQWLQDCHTKNKVPLLASGIMEPVPWSPEVLPVQIIKLGQFAIASLPFEVSTMSGRRIRKSVKAALTGLVSEVEVAAVSNAYAQYMTTREEYLAQNYEGASTHFGPNQLAAVQQELNRVAASIANPSIPLALGPLPRTFDRTQLATVQTGVVQDTYPLGISFGSVRTDVQKSYTIRSSVKASFVGGHPKNRLQLVASFCDAEKFDAATGTYKTFLTDAHWDVRFRWTRLGVTESNSECEWVLRSGSPVSVPGTYRLRHRGFSKPLIGDIKAYEGVSASFTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WZ81</accession>
    <name>A0A6G0WZ81_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">No apical meristem-associated C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_010194</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000128">
        <property type="protein sequence ID" value="KAF0732870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WZ81"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009019"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016705"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029466">
        <property type="entry name" value="NAM-associated_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45023">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45023:SF4">
        <property type="entry name" value="GLYCINE-RICH PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14303">
        <property type="entry name" value="NAM-associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="No apical meristem-associated C-terminal" evidence="2">
        <location>
            <begin position="290"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0732870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="414" mass="47311" checksum="F43EE99E2D517F6E" modified="2020-08-12" version="1">MFLYEHLSDAVFCVENNNYSASKKGKGNNNHDNDNQGHAIDNSEPGKQAERNAVQESTSTGAYGMAVDDDALNKGNINDEVAMRKAKKAEYNKRAREKKRQVLLDEVDKSKKAEYNNRTREKKRQALLDEVDKAKMAEYNNRARGKKRQALLEEVHKSKKADGLGWSEVEDMSLARAYVAVSHDPIVGNGQKSGAFWSRVHDEFKHLVPDTKRVSSSLPHRWSTLQRLVSKFAGYAKKVEDKHESGKRQEDQVSDAMSAFQAVEGKVFRHRDVWEYLRRESPKFFGIPSHEVDTEQENSNLIVSLDTNMASSTQQNDRPMGTKRAKLEAKHVEIEHETSAAIVSFVNEQREVMKRIAESVQQMAETQKANIANETAKRANQEEMDLFTININDLDEDAKEYILWTRQRVRDSHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WZ82</accession>
    <name>A0A6G0WZ82_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_010144</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000128">
        <property type="protein sequence ID" value="KAF0732814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WZ82"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013122"/>
    <dbReference type="OrthoDB" id="47276at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052993">
        <property type="entry name" value="CFA-57"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32215">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32215:SF0">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0732814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="129" mass="14015" checksum="E787E85C43F78E42" modified="2020-08-12" version="1">MTAPASANSSVLTHRYMYGLKGSVKNNIGFCDENVLAYPCGHCIVIHSIETKEQQFLQGIEGGASGGFTAMALTSNRKYIAIAEKGADNGLINIFDLTTFRRKKPLTYSDLGSDSYACHQLNDTLTDQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WZH3</accession>
    <name>A0A6G0WZH3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_010226</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000128">
        <property type="protein sequence ID" value="KAF0732904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WZH3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001910"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0732904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="93" mass="10670" checksum="20BD2F96DF2DBCF5" modified="2020-08-12" version="1">MALSESATWTNSVSPVWQSAWTKQNRVVCIEFLPDCVNPHHKDMYSKEDNPIEYATNAWLVDEMATMNFISLDDTDVDFSFTLDMEALVEAFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X0A2</accession>
    <name>A0A6G0X0A2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ae201684_009815</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Endomembrane system</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat SEC31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000124">
        <property type="protein sequence ID" value="KAF0733251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X0A2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017748"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007029">
        <property type="term" value="P:endoplasmic reticulum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024298">
        <property type="entry name" value="Sec16_Sec23-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040251">
        <property type="entry name" value="SEC31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009917">
        <property type="entry name" value="SRA1/Sec31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923">
        <property type="entry name" value="SEC31-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923:SF11">
        <property type="entry name" value="SECRETORY 31, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07304">
        <property type="entry name" value="SRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12931">
        <property type="entry name" value="TPR_Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="5 13" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="160"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="242"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Sec16 Sec23-binding" evidence="16">
        <location>
            <begin position="481"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="SRA1/Sec31" evidence="15">
        <location>
            <begin position="828"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="684"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="699"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="725"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="808"/>
            <end position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF12931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF0733251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="964" mass="104101" checksum="592CAF999AFF8C99" modified="2020-08-12" version="1">MPSAANAATAWSPIANESNMFALGTAESELHLVYFDLIRQDIPPNVIGRVPTAAPFRTLAWSPATRHQNAHPWGVIAGGLEDGTVAIWDPTQISSGQVQALSTVSKHNGPVTALQFNPIKESSHLLASGGADGNVWIISLNNLAAPGVFSPGTATPGTEITSISWNTTAAYILAAGSLDGRVTVWDLKQKKVCFEVHEYGPVKALAWSPEEGFLLMTASLHFPVIHIWDLRASNTVPLVELHGHHVGGIVSAAWCPHGSGIVVSTGTDNRTLLWDLKTREMIHDVSNHGAPRAHLQFSHQPGYVSSTTADGSVQVIHIRSGAASHVLRWNPHKVAEPAQTLPPNSTNAAPIPDPAAPAPIPPMAPVPSVTAEAPVANPASVPEPLVAISPEVLIASAVALEETTPEDFCDWKLAQSGLSDADRQTWSFLKVLFEPDARKQLLVHLGFDEFTGGALLLPRGDDAVVESGPLPVFTAASETAIKRSLLVGNFEAAVDICLEKNQLANALLLATCGGPELWHRTQEAFFQRQTRPFMKIVAAVIKNELDSLVQESDPTAWKETLSILSTYSKSDEFPGLCDQLAWRLLDVGDVFSASLCFICAMNMDKTVEIWSAIAPPTSDAALQGLVEKIHVLAQGTGQSADWYSPFYSQYATLMATLGKKNIALKYAKGDQAVLEHFKSPKLEPVKHASPSLDDVNPFDYKKVPNIPHEKPSLISPPPPEAHVDPSSTHEQTAYGYNSPPQEQTPYGYAFPAQEQAPFGYTPEPEPTPSSQEYQPSITHDFGHDQQPQYDSFAGHPAKELDESPPPVVETTPPLSSSSAPVSLFKAAAPTPPPATPPAPLPPMEKVPFVRTPAMHNIPDDDIVIVETLVELLSLLELQKLTSAETKQLAEAAKAKDVLVTKLDTGDLSPTVLQSVHDMTQALQRRDFKAAQQVHVALTSSHWALQKEWLRGLKAFFQLCTKRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X0E9</accession>
    <name>A0A6G0X0E9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Allantoicase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_009833</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the allantoicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000124">
        <property type="protein sequence ID" value="KAF0733270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X0E9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002752"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004037">
        <property type="term" value="F:allantoicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000077">
        <property type="entry name" value="Probable allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00813">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005164">
        <property type="entry name" value="Allantoicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015908">
        <property type="entry name" value="Allantoicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02961">
        <property type="entry name" value="allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12045">
        <property type="entry name" value="ALLANTOICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12045:SF3">
        <property type="entry name" value="INACTIVE ALLANTOICASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03561">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016516">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Allantoicase" evidence="2">
        <location>
            <begin position="27"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Allantoicase" evidence="2">
        <location>
            <begin position="219"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0733270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="380" mass="41877" checksum="3F73EF639623029F" modified="2020-08-12" version="1">MATMTTTKTVAPPPPPAFTALTSLSKGGKILFATDEWFAAADNLLSPTPPVFIAEKFTDFGKWMDGWESRRKRIPGHDWCIIELGLRGKIVGIDVDTAFFTGNNAPQVSIQAACLEPHVGSSLIRPRRMGTSASDDEFKAVEALQSAKWTEILPRSSLGPGYEATRHNYFEVESDQVFTHLRLNMFPDGGIARLHVYGIVSVDWSKIDGRVDLVAAANGGTAIYYSDAHYGEPRNLLNPGRGVNMGDGWETARKKTRPSVLTLDPQGLLQVPGSDFVVLKLGHVGIPDEVEVDTAHFKGNFPESCLVEGCLWHGSDDLKVLEHGEWTPLFPRTKLTADAIHRFQPTIPQRPINYIRLTIFPDGGISRFRLFGVKANPSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X197</accession>
    <name>A0A6G0X197_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_009548</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000121">
        <property type="protein sequence ID" value="KAF0733615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X197"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019568"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="254"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="400"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="437"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0733615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="507" mass="55247" checksum="51EA76C678CADF49" modified="2020-08-12" version="1">METDRLLLATAADPKALYTWRAIREEASTIWSMAWKISVATFCRLSVFTISTAFLGQLGTKELAASALAQSIIGGLRIVTWAFATSMSTLCGQAYGAKNYELVGIWLQMGLVVLVVISIPLVVAHFYAYLILQYVTSDVELLEMAQTFANYTALSVFPNAVYVAFRSYLRAQEIVTPTAVIDTANVFLSIGANYVFIYGWGSWSGFGFIGSPLASFFSATAQPIALFLYAFVFGQYHKKTWFGWSWQCVEATRLKQFVSLTSTFLVYLALDEWIYNVIAIVTAQLGSLNLAANSVLCNIWGLAYGVYMGFSTPIQVRVSHALGANDPVKAKHVMAVGFGLGAIATLVVMFAILVTRYSLVTVFTQDAALQEILVAMLPIFCVAAGISGFHVMLSSVLEAMSLALTLVFVSGVGSWAALLPASYYLGIQLNFGLAGLWWGSVIGEGVKFCITSTALFWLYDWAKIAQRISDEANGDEEVEDIEKEAQEAFVTVDTLKSPVAAVTNVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X1N6</accession>
    <name>A0A6G0X1N6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_009343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000119">
        <property type="protein sequence ID" value="KAF0733773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X1N6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009790"/>
    <dbReference type="OrthoDB" id="122652at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0733773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="21735" checksum="E397A40D4AF33765" modified="2020-08-12" version="1">MRNRLVQLRRPLKAVPRTKGNAPKENKLLLSPEQAKKKAAQEKAKAALMLRFSNENSYLNWARNGVLSSGVGVAMYAQEHHRGAQLSGAGLLLLGFGYIGVGSFKYMFYMWRFRKVMAASLPSVIASCSHAAIALGIWLTATASFLESIPLEMDVLLLEEPFIQYLPSRIAQGLIQTYNLQQDEYDTPTAPPPRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X2U4</accession>
    <name>A0A6G0X2U4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_009073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000117">
        <property type="protein sequence ID" value="KAF0734208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X2U4"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0734208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="113" mass="13016" checksum="8516A7F6E26B7E5B" modified="2020-08-12" version="1">MTQHRSALKEWFAATFHHVAKAKRIAIPECLAHETAPRHLVGGKLVPFLPNQAAIWRHHRDLKHCEPIDENLPVLRASPTIEKPQELRRPRSVFSSEPEEPTTETKKSLFLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X2X0</accession>
    <name>A0A6G0X2X0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_009053</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000117">
        <property type="protein sequence ID" value="KAF0734186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X2X0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007915"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013390"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07440">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF192">
        <property type="entry name" value="DOUBLE HIT, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01301">
        <property type="entry name" value="RGSPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="180"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="322"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="502"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="643"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0734186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="804" mass="90969" checksum="0262E3082E1B6B5B" modified="2020-08-12" version="1">MGSGASCVVSDQAHLFQVVQETYVAGTADSLDDQALFELIKAKLAQQVQQEEQTGPTADLAAVATNGPSMGDYHGTVDDGDEEQDHVFELPLSSRNTSSTSSLAGVAATSEGVPGENTRVLHSADSLPAMKGSSASSSPKTDKRRIQTMKNVHDPTKYRRASIVMDSVEDIDDAPEFTTDVLVNPATLKMMLEFCSDIPHAAERLQFWADIQHLRTLPSAQYTDKMLRKIYEKFLSPSAPTPICVPTEMILVIQKEAASPNGIQSAGIYLDAQSLCLRDLEKDVFPRFLKHKLFENMKTFCESKARESEENAHLSPREEIFTFHAVLSDDTKLRFLKSYCMENLTLENLLFHMEVEEAKRLPNQKYVHACARKLYETYLKPNAKKFVALPPEIHAEMTAKFEANALDGSSFTDVQYWVLDYVRTALWGGFAVHQPYIDHIHDGSLTPRHWDEYVPEVTETDVNNVLVQLETLDPEELISLAMNLPMDQLANVALAHKVHRDTLMLLVHDKIAHKIFKKFLASRFKDHYVNFIDEVEEFINLPGIEFMQHTAKKLFKKYLSENAKLQVDMSNKMRQDIQAKLNSPSIDMFRPAIVKVKTGLLQDSMVRYLKSPIHSEMKQDKEHVDLAKDLMTAVDKGKVDLPHLETVLANPKYLNNFRKYLKTQHAAENLIFLEEVDEFRRLPSYQIVVRSAKKILDKYINTNTSRSPIPIASHLHDEMVQNIDKAGKTFFSDAVQDVVSILRTTEVPDFLESPFFMQLIGAWIVLDETYAIRQLIGEVELAFFKHVVPLSRTTRHSRAPLSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X3V2</accession>
    <name>A0A6G0X3V2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_008814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000111">
        <property type="protein sequence ID" value="KAF0734572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X3V2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000534"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0734572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="149" mass="16330" checksum="E6D1EB261BD07587" modified="2020-08-12" version="1">MQLSYVAFPAYNFSLAIWATVHPVSSHHHTKTTVLFISILLLSCVTDVVWSSLWVSGSVFYDMLCQPARIGILQCDGLQSFPGCATNRFVMVLFVTNIALKMWIALSIWKAVAVADKKPDVVQAIEVAQPPGDTVVIQDVPTPTAIPIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X415</accession>
    <name>A0A6G0X415_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_008731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000109">
        <property type="protein sequence ID" value="KAF0734661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X415"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010104"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0734661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="330" mass="35627" checksum="B00CA21A2677499A" modified="2020-08-12" version="1">MDNAGPAVSGHILEGSFSSASHCVRALRDASSLIEGPLQRATDAGLNDVLALVRNHVVHLLGMHPRIPLDSIVVPAIYALISCAATAYGPGFRPAATLVVPFVVLHCSHSLSSIATEAQTCLQTLTQQSSYDLRPVLAQPHTNVNFSFHVAMHIPHMTATWPQDEVLPYHDALVHLLECCLFDMGYLTRAFAHRALTALYAYQMENLDHPAPISWYLAGLTALNILELQEQHPSSALVQAIQSHRSTASSSASNDDLDQIPTPTASSLSQDPSASPTVASTAILGVFLDQIQDQHTWTTTQATLFTDATARESYPPLLQVAALRHANLHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X4B8</accession>
    <name>A0A6G0X4B8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">VPS37 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_008668</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000107">
        <property type="protein sequence ID" value="KAF0734710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X4B8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019011"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11685">
        <property type="entry name" value="UEV_TSG101-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009851">
        <property type="entry name" value="Mod_r"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678:SF2">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07200">
        <property type="entry name" value="Mod_r"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51314">
        <property type="entry name" value="VPS37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS37 C-terminal" evidence="9">
        <location>
            <begin position="283"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="113"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="258"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0734710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="361" mass="40019" checksum="2139A4FECE73840A" modified="2020-08-12" version="1">MTSAVSELQRLRGRQVASLVRAGGQAINHQQSIFDVVVRLVDSRTLTLRITLPDDFPMQGPVIQTTSRVQHSWLDSQCRVVGHIDLTSWSAHADIGRIVSDIVTEFQRSPPVPIGRAATTPTPMYPDNSARPSSIPSYMQPFPPQASTYPQPPSMSTYPAAQAGYNGSAYQQPPSVQMPPVQPPLVQPPKRETVSHTQAPAIPAVFPELDQLSVNQLEKLVTDRATLKAYIKNMDSVVNFMKLYDDLVEGNQELADSNLAHESSISSLQVEIEELKHQLHTAQEGLNVKLAKQNELMTQFQPEPLVARVVDAADEADEASEEIASRFANGEIDVSQFVAEFQPIRKLFHLRTAKVDRYTHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X519</accession>
    <name>A0A6G0X519_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_008422</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000102">
        <property type="protein sequence ID" value="KAF0734945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X519"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000155"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0734945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="190" mass="22610" checksum="1E9777F9218FBD66" modified="2020-08-12" version="1">MEFTVVRDAETGEWIEVPLPKAAMDHEAQPQCLPLISTYEKVGMFTPYSVGKQGVTQSTRKLGTSVEWEKQAEKRRLKWEKRRQESVCHLRRQLEDSSLSPDEKRRIQIQLLEKMKSEYKHQLETVIQEELEREQGRSFAIEHEKSDVTRKRLQHQYNVERELYRTQIERIKEECNLSLTATMEKFNLLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X5H9</accession>
    <name>A0A6G0X5H9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NF-kappa-B-activating protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_008162</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NKAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000100">
        <property type="protein sequence ID" value="KAF0735245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X5H9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004265"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040466">
        <property type="entry name" value="NKAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009269">
        <property type="entry name" value="NKAP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13087">
        <property type="entry name" value="NF-KAPPA B ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13087:SF0">
        <property type="entry name" value="NFKB ACTIVATING PROTEIN LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06047">
        <property type="entry name" value="Nkap_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NF-kappa-B-activating protein C-terminal" evidence="3">
        <location>
            <begin position="168"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0735245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="293" mass="32973" checksum="04C67DEE2966C838" modified="2020-08-12" version="1">MDQVEETRTTLEEIVIQSRTGMDPEMAMGKMIFSLDDSPSEKQSKPSKKEKRPRTPSPPPSSSSEDEDERRRRKKKQSKRKSKSKKRRRQRTPSPSSSSSSSSSDDSSGDEAPSPPPRAATASPTYEKTTPLDEVRETTANSKRNNDDDEVIGPMPLPDSSIASKSVSYGKDLLPGEGAAIAQFVQKNMRIPRRGEVGWSGNEIEQLESAGYVMSGSRHQRMNAIRIRKENQVYSAEEKRALALINIEEKQQRENNILAEFREMLTERLTKKHGSLVVEERQDQHQASIEKDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X5Y6</accession>
    <name>A0A6G0X5Y6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_008198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000100">
        <property type="protein sequence ID" value="KAF0735283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X5Y6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003209"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052050">
        <property type="entry name" value="SecEffector_AnkRepeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586:SF3">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026023976" evidence="1">
        <location>
            <begin position="21"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0735283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="414" mass="46256" checksum="84992FB12045D845" modified="2020-08-12" version="1">MLSATLPMTLQLAVFSVLLSRELFLSIQAFQPGIPFHLQDIARAARVLQVASFQTSADRVRAELTRRNWFHAHGIRGLELLYQNCPDITCDGSFLAFAASVGHVEAVRYLLQHHPTHHGPAILQATQHGHFDVLELFHNIESTDGFTSYVMNLAAARGFLNIVRFLHDNRKEGCTHQAMDNAAKNGHLDIVKFLHAHRTEGCTTDAMDDAASSGHLDVVQFLHEKRTEGCTQKAMDGAVCGGHDSVFHFLHTHRSEGCSKKAMDAAAARGDFKLVQFLHWNRHEGCTIDALRTAAEHGHANVVEYLLRFRNEGCVKESIALGAAAGHVQVVQCILRFAMPCSKDHDCPPEFHGMSLLRVARRIARAHKQTFVLKVLNDLKPTWRDRRDVVKQKVVNVWKRVAFRARAIGLPSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X7G3</accession>
    <name>A0A6G0X7G3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tryptophan synthase beta chain-like PALP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_007902</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000093">
        <property type="protein sequence ID" value="KAF0735900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X7G3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005351"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000016">
        <property type="entry name" value="Cysteine synthase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="7">
        <location>
            <begin position="41"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0735900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="378" mass="40448" checksum="561C0514A92D1AC7" modified="2020-08-12" version="1">MSQAVQRLGAGLGLLGLGVAGGIWFERTNKPVEEEIVTLAEAIGNTPLLEIKSLSKLTGCRILAKAEFMNPSGSVKDRAAKYLIEDAERTGKLKPNGTVVEATGGNTGVGLAIAAASKGYRTIFTMPDKTSDEKVELMRVLGAQVHVQPSVGLSSELNFYNLAKKIVASDPMCFGPDQFENTANSMAHYKGTGPEIWRQTAGKVDGFVAASGTGGTIGGVSKFLKEQNPSIQVWHIDPLEGGASSDYINSKQTNSWINKANGFEYIPQREGATIAEGIGLSRVTPNFKLGQMDKGVFGTNAEIVQMAYHLLRHDGIFVGPSAALNIVGAVKMARELGPGHTIVTILCDGGDRYRSKLYNAKYLEEQKLSEFVNAPLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X802</accession>
    <name>A0A6G0X802_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ankyrin repeat-containing domain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_007228</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X802"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002448"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052050">
        <property type="entry name" value="SecEffector_AnkRepeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586:SF3">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0736205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="337" mass="38070" checksum="C5E7926E3E1B0D28" modified="2020-08-12" version="1">MGRCVSASQGLAPPSSSCASSSREMRFYWLQSWRRNSELSPWRALQVLVNVDLFRTITSFMPGVARMIRAMHSRAMRQTGPYARAHFIVSSLPRSNIDRLYIAKQLHQAYPLAFTKSVMDLVAKAGYLDVLEFMHQECRRGCSKNAMDLAAAHGHLEIVEFLHEHRTEGCSTDAMDRAAAGGYLEIVRFLHTHRTEGCTLNALNLAAAHGHLQVVQYLTRHCDLQESGIWPSGYHHEWLAFKRICHTSESQTALMEEEDPRLESPMDYAVLKDEDESRLLSPIDWATLHGHLPVVEYLFREGILASCRVSVAIATVATERGHTDTVRYLVANDLVHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X9I5</accession>
    <name>A0A6G0X9I5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Choline/carnitine acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_007554</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X9I5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006314"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004095">
        <property type="term" value="F:carnitine O-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.20:FF:000001">
        <property type="entry name" value="carnitine O-palmitoyltransferase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.20">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042572">
        <property type="entry name" value="Carn_acyl_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF16">
        <property type="entry name" value="CARNITINE O-PALMITOYLTRANSFERASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="8">
        <location>
            <begin position="44"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0736544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="638" mass="71265" checksum="25133655B5CB1002" modified="2020-08-12" version="1">MVLPRQFNTLSHARRCFSVAHRPSGYVQETVIPTYHFQKSLTRLPIPKLDDTLNRYLLAVQPVVSPSEFEDTNRAVEKFRKQGGPELHAALVERDNAAPETSYINKWWFDMYVQDRSPIVINVNPQIKIKDDPLPEKNTQNQRAASLIASSVRVFRTLRDLKLEPDIFHTKPNYSKTAAFNTFCKLLPESISFYGAAAFGAYPLDMSQYKNLFHSTRVPQVGQDKLQLYPDSKHVVVQYGSKFYKFDVLDQNGGAVPDADILANIDAILAQPLENELGVGLFTTLNRDEWAKTRTKLIQSQRNAANINDIDSALFVVSLESKSPETPAEISRTFLHGDGSNHWFDKSFQLIIARNGKASVNFEHSWGDGVAVLRYLNEMYTDSVKHGALPSGKASITPLSWELNEELKQTLKNAKKTFDDWTARLLIEVAESPVTRQIGAQYGIGTDGVMQMTIQLAHYRLHQGFGSTYESASTAAFKHGRTETVRSCTNEAVQFCQQMESKQSSSAEKAAALRTAVKKHSELTKNGVMGQGCDRHLFGLRMMATIQGQELPELFNLPTAAIMNRIILSTSTLSSPNLDGGSFGPVNEDCYGIGYGIENQGSLFQLASYRKDLPDLKGLLVSSLQDIETILKETHKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X9S3</accession>
    <name>A0A6G0X9S3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_007012</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000087">
        <property type="protein sequence ID" value="KAF0736856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X9S3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017800"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000286">
        <property type="entry name" value="Heat shock transcription factor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="6">
        <location>
            <begin position="40"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="HSF-type DNA-binding" evidence="6">
        <location>
            <begin position="277"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="137"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="158"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0736856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="376" mass="43106" checksum="9CA64AE0231EBBCA" modified="2020-08-12" version="1">MDEERRSLLDRPTKLDHISLSMPTTSLSVPMQMEACKRGWVAPFLLHLHQMLRREPPHIIRWTADGKAFEILDKKTMTEKVLPKYFRNKNFASFQRQLNYFGFRKWSKSRAMYSTYSREHFTRDNFDELVYVKRQSKKKSSKDESSDKSDVDMDESSSTETSFSPSSPSTSPSLDAQPDIALPAQTLLDMQHMDTSTHSPVQLSRVAPMPFSFSLPALSEMRQTSPHVGLRLPSIHQIVPSMHSSSSVWPMDNEDLNSPSLSKAKIDYNVKELVGLSAARFIRGLYDMISSDSGDCIRWSEDGASFVVVNSAKLAWEALPKYFRHNKFRSFQQQLNMYGFQKWSKARAAACTYSHPLFRRGQFTDLCRIARKTGMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XA79</accession>
    <name>A0A6G0XA79_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_006835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000085">
        <property type="protein sequence ID" value="KAF0737025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XA79"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0737025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="137" mass="15695" checksum="0A5C88C78807D148" modified="2020-08-12" version="1">MPRGHSVDDGVAKLSKLAPRGFKHALAIEAWITRLRGHKQTCDCQRMRSSCLTRLCFVSLSPNGVTRPQDIYPRVVGKPRQFETFYHPSVVVWREREHRMPCRRDLLSCDVTLRSHLEDSLENPVASTVLINFALIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XAT2</accession>
    <name>A0A6G0XAT2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">4-hydroxyphenylpyruvate dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_006409</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="10">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 3/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the 4HPPD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XAT2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010122"/>
    <dbReference type="OrthoDB" id="414569at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003868">
        <property type="term" value="F:4-hydroxyphenylpyruvate dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07250">
        <property type="entry name" value="HPPD_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08342">
        <property type="entry name" value="HPPD_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.180.10:FF:000013">
        <property type="entry name" value="4-hydroxyphenylpyruvate dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005956">
        <property type="entry name" value="4OHPhenylPyrv_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041735">
        <property type="entry name" value="4OHPhenylPyrv_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041736">
        <property type="entry name" value="4OHPhenylPyrv_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01263">
        <property type="entry name" value="4HPPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959">
        <property type="entry name" value="4-HYDROXYPHENYLPYRUVATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959:SF1">
        <property type="entry name" value="4-HYDROXYPHENYLPYRUVATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009283">
        <property type="entry name" value="HPP_dOase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="VOC" evidence="11">
        <location>
            <begin position="32"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="11">
        <location>
            <begin position="203"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR009283-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0737232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="419" mass="46689" checksum="D887F18AC5091CD7" modified="2020-08-12" version="1">MAATSNNKKMTLVGHDNFVRHNPMSDKFVMHKFHHVEFYCQDATNVSRRFSWGAGLKLIAKSDQSTGNHAYASYVLKSGELQFVITAPYSRLNQKADSVPPHRGFDNAFAHEFCVKHGLAVRAMAITVDDAAVAYDVSVKNGAISVMAPMTTKDETTGETLTFSEVQLYGDVVLRYVSGNYSGRYMPGYENVEGPEVSIGLERLDHAVGNVPNLMEAVNYVCDFTGWHEFSEFTAEDVGTVDSGLNSMVLANNNELILLPMNEPTFGTKRKSQIQTFLEQNEGPGLQHMALKTNDIFHTMSEMRKRTHLGGFDFMPKPSDNYYKNLPNKIGDVFTPAQYEQIEQLGLLVDKDDQGILLQIFTKPLGDRATCFFEIIERVGCMEDIGGRLEQAAGCGGFGKGNFSELFKSIEQYERTLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XBP7</accession>
    <name>A0A6G0XBP7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_006550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XBP7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021751"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="13"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="135"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="226"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0737385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="456" mass="53660" checksum="CF0506FA37BEA198" modified="2020-08-12" version="1">MSVWPKKAWSIEEELLKKKNKSIEDKYQSLLSEYQELRVENAKTNAKLREMERYKEISDDIVNSASSSRRMEEKERIEIASQLQQYREKLEEAVDNICFLEKENKRLKSELTSAKLDATTSNVLLKNLDDSKTKLSTTESRIQMMRIEILELKNRKADLHSQVQDLKARLHAAETLADKKGEECKRLNRKLESVESAWDSTRSQNHRIQKEIRSVAEVADLNRELSEKSKHRVASLENEVESLEIKLKARDRTIEARLFDCMLRKRLLKKDFTELQAINKELRRVSNEHAKHDSEAEQTLSMNETEIKCLRDMNRTSAERIEELMAENSKLQQQLLEVHGDFLKKVQLDSSWKHKEKEKYVFQLTVFLHLDAHGMARLRREVEEEMDVLKKPRVCKNCHESFTLEKNTAQSCTYHPGRYLPRQYPLEGYSWSCCCKRDISSRPCKFAGRHVERDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XCD8</accession>
    <name>A0A6G0XCD8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_006357</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000083">
        <property type="protein sequence ID" value="KAF0737692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XCD8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019753"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169:SF2">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0737692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="27403" checksum="DDE386E8FD7898C7" modified="2020-08-12" version="1">MFLAAVARPRYDYKRREMFDGKLGIWPFVHRVPALRSSVNRPRGTIVTHPKQVNAASYLEMLQQNFVSAIKAKMPAAARRRTVFIQHDNAGPHSSSVVKAIAAMEQGDGWNIQMRNQPPNSPDFNVLDLGFFNAIQSLQHQPTPSNIDELIGAVLHAFDELPHETLGRTFVTLQKVLEISIRMEGSNGYKLPHLKKDGTIEDISTFNVACEESSSVLALAKLNMRLEDESALEELLDSPDEVAIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XCT2</accession>
    <name>A0A6G0XCT2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_005940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0737944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XCT2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021212"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF37">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13456">
        <property type="entry name" value="RVT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="227"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0737944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="385" mass="43108" checksum="14A2EB3CC60FFBB0" modified="2020-08-12" version="1">MQSFLGSLNFYSRFIENYSILASCLYEISDEELRLGLVSPAAVRAFADLKAAYSSTPLLRHADPEREFHVLLYTTTWAISATVCQDYDGVLHPVRFCGRTLKGGEPRYEEWAKEALALLRAAKVCYYELRNMQLVVYSRHGLLKWILADKHGKADHLPWAAILSPWTIRVEQVVELDERWALPIRLMDILHPPDASTLADMDVYKPNKAKDVQVSQRQAALPQFGPDERATVVSFDGAIKAKEKVGSYGFVIWQLPGWSVLWAENGVFADATVNLAEYNGLIAALERVLSLSVVNPVIFGDSRLVIHQVLGWMQSKQPHLQHCLDRVRTLRDQATGVEFHHVKREWNGAADLLAGLALQDRAAGAAATCHHCRAPDDHGISSEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XD98</accession>
    <name>A0A6G0XD98_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_006157</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0738180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XD98"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020545"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016462">
        <property type="term" value="F:pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006753">
        <property type="term" value="P:nucleoside phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019693">
        <property type="term" value="P:ribose phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18888">
        <property type="entry name" value="NUDIX_ADPRase_Nudt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839:SF1">
        <property type="entry name" value="ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839">
        <property type="entry name" value="UDP/ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="48"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0738180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="198" mass="22108" checksum="D41C1530B5890711" modified="2020-08-12" version="1">MPRLPRVVVSHILHETKWLRMKELRYQDLNKVERSYISVERTTRPATADVDAVLVLPLLRRPGHDAQAVLIRQFRPPLDNWAIELPAGLIDEGESVESTVVREIKEETGLRVTKFLSVGPPIVNDQGITNGSCRFVVVEVEDDSADGSQQQLEATETIQVFKTPLSSLRATLDAKHAKDGDAIDARLYSFALGQELSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XDD0</accession>
    <name>A0A6G0XDD0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_006058</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0738067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XDD0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018723"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="7"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0738067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="341" mass="36569" checksum="5FD6009C4AF632E8" modified="2020-08-12" version="1">MQAQLTMDAHRRELDATKAELQACREKLESALGEVQEKAEHVQVMVSYFNDVVDGQMKPQLLEAETTASQLRDQVAALSNDLASVKSQLTQKTKESEHLKEQVAALTSELEAAKGEVSEKNTATILLEDQVATLKTALHEKSRADGNKMCIVSLVVAVVAHAWSLLVAVMSWTWMFAMSACPKVKTWSTAVIATDKATDKATDKNDQDVKREQWSVGRMSVVGLLLVGVGVLVFLGVTTIATKDGTLTHPLHDVTSGPLPWMPSGLAGDAIPMVVDGTSSMGLDDGDETQDDDPEENELVGSMVGTAFGVATTTAGCVLKVWVGWALVSSLVQLYAGCRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XDP9</accession>
    <name>A0A6G0XDP9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_005857</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000077">
        <property type="protein sequence ID" value="KAF0738299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XDP9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004234"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006560"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011171"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="84"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="829"/>
            <end position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0738299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="849" mass="96047" checksum="7066BF552E0104A3" modified="2020-08-12" version="1">MVEPSQAPPPDPTTREAVLDHLQTALSADQRDELDSPLTADELCSAIKSMRKNKSPGLDGWPAAFFQTAPEKFAAILVIVYEYQRKTHGLLLPHQRKSSITLLYKKGERADPGNYRPIALMPVEVKILSRVLARRLSSVAHILVHPTQSGFIKGRSMNDHIHLIQALQHRATRTNEEWYATFLDFAKAYDMVRWSFLFEVLERMNIGPEFRDWVQLLYKKNQVLLLLNGALGPPIRPSRGVKQGCPLSCILFDLYLEPLGAMLRAHPEAGILLDNDNTLTSIFFADDSTLLSGSLESAEFQVDEIVGQFCAVSGAALNKAKCITLALNDNEEPLGRPSAPSITLSKSGEPIRFLGAYVGHRLDPLYHVHHINDKYLAAFSQWSCPARTIQGRRALATSMILGLIWHVTSVTPIPNGILLQWQKMLTKFIIGGHSSVDSSFRSPINKEWLFDKRLGLGIPHIASIIRGQRLRLLQRFIYESNTSPPPPWTTLVANQFANCTRSIHSPNRPYDFLWYSPQHSSAWLNLAELHPLWQDVWKSWSSVPTKYKLPLRPDFPTMLHMPFWLTSYNEFLHNGSVTPATLVSRSTEARLWCQHGVTNDVRCLYDILHLSTPRGRWPDFQQFLGLMSSGNPFCTVSLQHDGIWFSPVPRARGLYDHLTNVYHSVCARCQEDPLLHNIDKDPQPHAFRALVRDRIQPFEFWPRKLVARMAFQGPIPTSPHPTYTPQRHNHDKARSYMSLVRKSPQWITPVHADVWLRAILKMLPVNDRFKYTTCLVSRNDDFAPTTVVPTKQLPTRCTNAPPSPQSGQLTLLHGSSMVYPSHGVYPPTWTRSKSKPAPDLSKMCSSSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XEA4</accession>
    <name>A0A6G0XEA4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_005783</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000076">
        <property type="protein sequence ID" value="KAF0738346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XEA4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015383"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="465"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="512"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="482"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0738346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="531" mass="59541" checksum="C76B3B5188F1BDB6" modified="2020-08-12" version="1">MSVADSMHMWDEIARLKLQVSELQQHEKTLLEANKVAADERKRFATQPQLDAGLSLKASTTMMDVEIAKVRQELLAALDKKADVTLVDHTFQRKLDVSIFEAHQHAMAKMRSQLEQLIKDMFAALALPIERDVRDVKDHLEMYEKRLGSAAQAIDMAKHQDTLLSDRLKALERKCKCDDDDKDNNAATEQFFRGDSATTFRSFGHAINALHAKHVASQSHAATLESKLESMQAALDAVHVEATKSHVDVSALVAAEMRHMQPIDAKIVHEIQAAQREMADKIKLAQATATTAVNAVDAFKTNASQLLQAACDDKIAHSVRLLPQRRALTAVLSQVQVMAKQNNQLRDLVQRNQVIAAEQCHQLRTKLDTSSASHANLEKELRAVARQCDLTARDVTEMKGPFMTEVRNLQHENSAILSEIQRQQDVSRELVLDYKSQVVATKPQQTRQLRPQSCNVAKRHVLNDVGRPARPKERAQTAGPKRKPDLYHHFGHTEPIDMSYLPSKSLSMDSNNNLESLLGDGPTPRHHRFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XEZ4</accession>
    <name>A0A6G0XEZ4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_005524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000071">
        <property type="protein sequence ID" value="KAF0738596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XEZ4"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0738596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="121" mass="12350" checksum="EA0225A728758306" modified="2020-08-12" version="1">MLQETPTAMAVMLLGELVGVGVDVVEAGTVVVVGVTVGIMVVVGGGVGAIVVVVVVVAGRCDVVSGGVSDVGRGVNIGKSGLSLVQSVPREQSSAVEQIYCDPLDEDRIQEPQSYNERTQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XFS0</accession>
    <name>A0A6G0XFS0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ae201684_005268</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000067">
        <property type="protein sequence ID" value="KAF0739088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XFS0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016008"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030991">
        <property type="term" value="C:intraciliary transport particle A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097730">
        <property type="term" value="C:non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000004">
        <property type="entry name" value="WD repeat-containing protein 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056158">
        <property type="entry name" value="Beta-prop_IFT121_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056159">
        <property type="entry name" value="Beta-prop_IFT121_TULP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039857">
        <property type="entry name" value="Ift122/121"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057979">
        <property type="entry name" value="TPR_IFT121"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057361">
        <property type="entry name" value="TPR_WDR35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017233">
        <property type="entry name" value="WDR35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056170">
        <property type="entry name" value="Znf_IFT121-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12764:SF5">
        <property type="entry name" value="LD29485P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12764">
        <property type="entry name" value="WD REPEAT DOMAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23390">
        <property type="entry name" value="Beta-prop_WDR35_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24797">
        <property type="entry name" value="Beta-prop_WDR35_TULP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25768">
        <property type="entry name" value="TPR_IFT121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25170">
        <property type="entry name" value="TPR_WDR35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23145">
        <property type="entry name" value="Zf_2nd_IFT121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037536">
        <property type="entry name" value="WD_repeat_p35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="IFT121/TULP4 N-terminal" evidence="12">
        <location>
            <begin position="1"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="69"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="IFT121 second beta-propeller" evidence="11">
        <location>
            <begin position="340"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="IFT121-like TPR repeats" evidence="13">
        <location>
            <begin position="1033"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="domain" description="IFT121-like zinc finger" evidence="10">
        <location>
            <begin position="1160"/>
            <end position="1202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF24797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF25768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF0739088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1203" mass="135002" checksum="06D22FDF86A6B6B3" modified="2020-08-12" version="1">MFIFLSKKIAIPNGAQLCCASWNPEQGWIACGGQNGLLKVLKLESAPTKDGKGPRGIAAQSNLTMNQSLDGHAGSVVCATWNASYKKLTTSDENGLIIVWMMHRGMWYEEMINNRNKSVVKDMKWSSDGQKICIAYEDGAVIVGSVDGNRLWGKEMKVELCFVEWSPDGKHLVFVTKDGDVSIHDGSGNKLCNMALYAVDEKDKKSYKIVGLHWYDGCEGHISEDAPTLAIAFADGKVQITRGRYDDSAVLIDTGVELSQCKWNCDGTVLALAGTQKGRGSDGREYNIVQFYDPFGRHLKSLKVPGSKIEALAWEGTGLRICLAVDSHIYFANIRPDYRWGFYGTTLVYAYNRPDQVENCVVFWDTRSDERYIKYVKSLLAIKAAGDNAVLVSKVVNDNQQTISESVDGTTTTSSMDAPLPAKQYSLVLCDTIGSPVETRMIDFEPLFLTMTPRHIVAASADAIYMWQYRSNVSKLSVNGATESSNVTTRGGRECIFYVDDLQGSDVEHFRYVERQLEDPICAICASETWLMVGRASGMIHGFTLPHISLEMKYIVPCRPQMLALNSNSTLMSIVDINGVLSIMEVGPSTGNQNPVDAKMLAFEKKDVWDMLWAEDNPELFVMMEKARMYVYRNLEPEEPVLSSGYLCSYKDLQVKAALLDEILASPEQTDKSLIIDYETRSLRDARELLDNVGLADACDYIQDHSHPRLWRLLADAALEQLDFPMAERGFVKCCDYNGIQYVKRLQLLNDRVKQKAEVAAYFQRFDDAEALYRKIDRKDLAIELRKRLGDWFRVVQLVQSGGGDDTLLNHSWNMIGEYYADRHKWEKAIKYYAQANNIPALVQCYYTLGDFATLDTLVNDIPEGSPLLEEMARKFTRAGLCNSAVNAFLKMGDIKSAIDSCVLLNEWERAVTLAETHHFRQIESVLAKYGAHLMRNGKTLQAIELYRRANKSMDAAKLLGKLAKDVSKNPLRAKKLQVLAALEVERFRRKMLDTSVLTTKATTAATAAQVTAQTLESLVAHDAATSESRSLDNAWRGAEAYHLSLLAHRQLYRGQPERALRTSVKLASYDDILDEREVYSLIAVAAYYTKHFEQCSRALNHLEELVVDKDKEALDRLALKIFSTTRPFDPATRPHDCPSCKHPVKEWASKCDSCGRSFQTCMMSGATILDHRTYLCKTCRHSCIENEIRDASNCPLCHASLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XIF9</accession>
    <name>A0A6G0XIF9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_004526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000056">
        <property type="protein sequence ID" value="KAF0739944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XIF9"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0739944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="94" mass="10169" checksum="2077202FD31EFC8C" modified="2020-08-12" version="1">MSKRINSASGTSALTGATESTSTREAITGSVKFCCEVRRLGAVGRTKTLAAHARKMFHATHEVISTVLVVSPVPHFACLLQAPRRMQKWQGKCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XIK0</accession>
    <name>A0A6G0XIK0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HIG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_004400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000054">
        <property type="protein sequence ID" value="KAF0740166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XIK0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017113"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0740166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="77" mass="8534" checksum="CF4CCE2957BEFFAE" modified="2020-08-12" version="1">MLDNAAESDKYIATALCSMSVASYAYYRDAQKFIARHGTLTMRAHKSAAGAGLVLGCAVGIYSFAYTEWRRKQRYNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJA3</accession>
    <name>A0A6G0XJA3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VASt domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_004293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000053">
        <property type="protein sequence ID" value="KAF0740294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJA3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004756"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0740294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="674" mass="75769" checksum="812FA3CDA992B361" modified="2020-08-12" version="1">MKVKQGHVGGIAMGAVLGMFWMRVVLGFSYLQIVFFMIFPLSFTIVVVMEERSLGPAIDLLLVKVRSLVWMAMHADDPTPPPMESTVDPFDETCHPRPSDPVLDAELKMSNTSDLITSANSSLFAGIHMDLIDHSVVHDESVYLQDTATGLFLKYADGKIKLTATPDEACLFEWIKGKTHHWGLVSKVSQKFIGQNMLSQIIATAKKLQNWEAFRVLQDATSPTMQNDLSAPIYMILCSSRFGKGMWLTGRGRDEDKHVVGLSKNFNFAVRLRYSSQLAAFHTALSPEHSPVADIFPTSFQEAAEVTPILTKCTFPPSPRFDSLSLFADAYDTLLPEHHSAWQVRPALGNVRYVTYPLHHLGVGCLAHEFHCYDLVDNLLWFRTKLILGPGLVPNFAFELTYQVELTATAVVLDCTVGVHWVQQPPSMFESYVKACAEHAAGLHAKHLVALMEHQTAPRVVTNLATLFVTSLHNAFDSPTYELNVPWNKTPFFSASLTPVYSGAWPISPETYLERMLSDAAWFFRVRDELSRPTTLDMSPWSLHPTLGHVRVHRFTTCVGGRDELVEEYQTYSSPEPNTLQFGRKLYLAHRKQWTVDIRWDFEQQDESSSVVATAVAFHWATPRADHADVEKHVTAVITASIERLHVLVTSQEELENMPWPDQLTAPIVRAMCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJL5</accession>
    <name>A0A6G0XJL5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_004190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000052">
        <property type="protein sequence ID" value="KAF0740456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJL5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010466"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0740456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="259" mass="29205" checksum="D9E6096FC4A759EA" modified="2020-08-12" version="1">MFNGLSAKLACSTRNRPSGHLLSDGVPFRIGLRVWWKRKGVRNECWCDGGHYGSVGYKVVLRTNQTASPYQPTMNPIDDSGDGTTVFQVLETPGPGRDSNRERSSIAYEMLRPLKSIFPTTTSSSLTSRPPPIAVDKKSLLREMETHLELESQCACMWSLCEETRVEQEAQFDDLHARLQHYTAWIASTADHAAHPNWNVIHDMVHVQLPKVLAHLEVKIAANQAKTRQIRHQLDAMRAKRHALQDQILLTTTTESRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJM3</accession>
    <name>A0A6G0XJM3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RanBD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_004126</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000052">
        <property type="protein sequence ID" value="KAF0740389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJM3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005169"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053074">
        <property type="entry name" value="NPC_Nucleoporin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015007">
        <property type="entry name" value="NUP2/50/61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38697">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SIMILAR TO S. CEREVISIAE NUP2 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38697:SF1">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SIMILAR TO S. CEREVISIAE NUP2 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08911">
        <property type="entry name" value="NUP50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RanBD1" evidence="9">
        <location>
            <begin position="539"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="258"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="336"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="432"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="503"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="74"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="258"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="277"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="367"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0740389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="648" mass="66378" checksum="CEFDC0A259BD5E2B" modified="2020-08-12" version="1">MSKRRNDNAQLRREEYEAMEDDDSSQGFGGPARATDDVIAKRRIVVAKGAKRSSASKSNATSSVPAPPTANAFASLSKPAAPSTTTSSNPFASLAPAPAPTTTSANPFAAFKGLVPSAPTSSTTAKTTESANPFAAFKGLAPSAPASSTQSTLSVPSPKPAPVVSKPTASTFAAPSSVSTASGKSLTFSWIESKVANLSSREEALSTCMELLNKEFFAFVQQQVVENPMSLWTKSIQEYIQHVEALEKDLDVLYGKKPTSSANSSKSPTAPFSFGIPSTTPTTPKETTSNDNGSAAKPPASVEKETTKASSVPAFTFGSKSSETKPSIFTFGTATTTSTTATPSSSSDAAKPASSATGFTFGDKPASTTSSSGFSFGDKPASSASSTGFSFGDKPASTTTSSGGFSFGDKPAASSTPSTGFSFGDKPAAASSSSGFSFGNPSTSSSSSGFSFGQPPKAPALGEAATPSSTTSSGIAFGAKASAPAAPAAGGFSFNLPKPAATASAATPAGATGQGGDDDEDDENIGREEATVIIKSDSESNETVLFEEEAVRLRQFKSAEKEWANLGSHAFKLLQNKTTKATRILVRNSIGKIMVNAALYAGMKVQANPKSLVMPLMNDGKLANYLFAMAPARVTDLKKEIDNSIPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XL73</accession>
    <name>A0A6G0XL73_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_003672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000041">
        <property type="protein sequence ID" value="KAF0741103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XL73"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001851"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="33"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0741103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="354" mass="38914" checksum="2B3D7E33C4A99BE8" modified="2020-08-12" version="1">MMSTLASHFDQRLGLHGDRTPWIAFSIMPRTAFITGATGFVGTNVVNCLLRDGWEITALVRANSKTEALNQRGVKCVEGVLWDAKSVANAMPHNVDCVFHIAATVAAWKPREAEQWQTNVDGTQAVIDAALQCKAKRFVHCSSGGVYGETQSVIEDTTPRDGDKSAVHYFRSKHAAEERVRDAIAKRNLPAVIIQPSAIIGPHDTTGFARVIMMVNQGKLQGIPPGAAAFCYGPSVAEAIVAAADKGRIGEHYILPGENSTFHNLVLRVSKLLGKTETRGPMPLWLLKMIGRVSDFVSWFTHKEPEMSYEVVLMVSYQSSVKSTKAAKELGYQALTLDELLPPTLDWLRQEHYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XLU6</accession>
    <name>A0A6G0XLU6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_003482</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="VJMJ01000037">
        <property type="protein sequence ID" value="KAF0741372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XLU6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010587"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05579">
        <property type="entry name" value="STKc_MAST_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE GREATWALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="335"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="10">
        <location>
            <begin position="656"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0741372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="762" mass="87136" checksum="D6C67AB54ED73B1C" modified="2020-08-12" version="1">MSIMEVLPDELFPSTHNLLRQFSLNIPRPGTQLLHQKAVCSARQRWQQYQMRWRLPQDAESDATIFHDDIVEAIFGESTLGIEFTIDDTTDRVVIKNCASVRKDQIQLVVGETIYKGLVVDAINDQQVDGMSGEDVLQLLASTARPMYVSFTTCDSRMVVCRLCECRVEASHLDEHTEYCISSKKHEQAASHLNDMLHRIAESIESNMQTEYMRSYFSDSDLQFYKTIRYISMQAAACELSSVDSFDLCVRLMKMLDHDRERSTSSFVVDRGMKYCQRIRHLIHAKMGQMRKTQKKMLHQAPATVYRTKSLENQDNNRRHTTILQKPLRVTIQDFDIIKPISKGAFGKVYLAKKKTTGDQYAIKVLAKEHVLRKKQLPNIEAERDILASVESPFVVKLFWTFQSPHNLFLVMEYLPGGDFMSLLECLVRLEERVACIYIAEIALALNHLHSKGCVHRDLKPDNILIGSNGHIKLTDFGLSEEGVSMNDAPMEEDRHSDSDDSSCHAFDDKDDLLEVNEILFDDDASEPLGDMRQEFLNAFTESPKAVESKKTSHQRCGTPDYLSPEILLGFKHGTPVDYWALGVILYEMLVGFPPFNDDTVEAIFSNILHRRIVWPNEDQCLSPHVEDLINRLLDLDPETRMGWDELINHPFFQDHDINWGTLLETTPPFVPTLDDPYDTSYFNNRNLTEAFVDDHVALTKSIEIPSKKGTRERIASPTVTPEAFRTFSFTNMNALVAAGREEAHEKIVTNDQASSTHNLWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XM73</accession>
    <name>A0A6G0XM73_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BAG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_003440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000037">
        <property type="protein sequence ID" value="KAF0741328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XM73"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016735"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.120">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036533">
        <property type="entry name" value="BAG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003103">
        <property type="entry name" value="BAG_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02179">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63491">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51035">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAG" evidence="2">
        <location>
            <begin position="62"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0741328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="327" mass="38047" checksum="10DB8EB5DAA63879" modified="2020-08-12" version="1">MTRNIKAIEQLSSIHEELRRIQDVLESRLPTQYKLVASEIAAAKWLSLIDNDKAKSREKACSLRVKNYRYRVLEQAERLTRLLCELDVIESDGDEEIRKQRKQTVLSVQGKLDIADTMKLQCDRLLDFHQRMLLLVPSRPTSSIQTQSSPAADTTDDDNEDMEEEDDNASDASEATSKEEDEEMDHMSKLPMWKPKWEMYESADDSIHLVANLAGVNLDRHLDIRVHGDTLRLSGIKLPSKKDLHIQQWFVPREPSFGRFTIEETFPRRYFNLSNATVRVLPNGHVDIRVPRRRVRQRVTPYMRSQWPAALTDFGLAWERVWESCIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XME1</accession>
    <name>A0A6G0XME1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycoside hydrolase family 5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_003308</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000036">
        <property type="protein sequence ID" value="KAF0741632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XME1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011102"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034411">
        <property type="term" value="P:cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF2">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="438"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0741632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="491" mass="52532" checksum="EFB8D409C007EAFA" modified="2020-08-12" version="1">MKSQALLSLYAAAVMAIKPIEIKGTHMFEYGTGKPFQVRGVDYYPRPNAGLLDVNNHDFFTDDYQDVWENHIKEFIALGVNAVRLYAVDPSKSHDKFMCALSGAGIYVLVDLASSCENCAITSDPHPACYPAALKTRGQQIITAFSKYNNVLGFSAGNEVNHVVTNMNTNAPCQKKFIRDMRAFVSSCASKMRSIPVGVVLADTDRGPNALYYGCRTNPNDVLENVEWYGLNAYLQCDPLASLNPTVVGAGYRNLLTDFQSYKLPFPSLLTEFGCLNSGFPTKQGYAAQRTWLDAGWLLSSTFSDVFAGGFAFEFSTENANSKADSPHPFTSFGTQNYGLGYFSPVTCDSTSTPCKFNRMPNFDDLATQYLNTNSTAALPVKSAYTPTITSFPACPAGVPGLSGVTWPSDSQTDMLCPDLTQTPLCPGDVINTATGTTLPPSTATVSPVPNVPTVTPASTGGSQGSAGYQSASTPASVSAVVVVAIALLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XNL1</accession>
    <name>A0A6G0XNL1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_003002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000034">
        <property type="protein sequence ID" value="KAF0741810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XNL1"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0741810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="127" mass="13789" checksum="79874A908C3D1EBB" modified="2020-08-12" version="1">MAGQACNPDGSSQPQIRRARLLLPRSSRLKTSILTPSTLVPATAIHIPAETSTMARQSPVLTKDFKMYAEQITHDKRVQFRVVTNLFNSTSWPPSIVCSLWNQSIGGPTATSLQSSAVEVCFASTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XPD4</accession>
    <name>A0A6G0XPD4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_002780</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Folate-biopterin transporter (TC 2.A.71) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000030">
        <property type="protein sequence ID" value="KAF0742108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XPD4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000193"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039309">
        <property type="entry name" value="BT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585">
        <property type="entry name" value="FOLATE-BIOPTERIN TRANSPORTER 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585:SF5">
        <property type="entry name" value="RNA-BINDING S4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03092">
        <property type="entry name" value="BT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="384"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="432"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="470"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0742108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="505" mass="55798" checksum="496CEFB5D9E4F266" modified="2020-08-12" version="1">MDAVYHAFDHAFDIEHSPRKVTSRTTSTDSLWSLRNCAIPLNYICIGIIITFPNAFIEYFPRQLGASDSQLSTISVVRNLPWTFKVLYGVLADVYPIAGHRFKPYMVLGYAIASLFNLVLAIYSPDMTVVTFTALLFFSMLGLIMVDVMADALLTQKAMAEPEAVRGQLQGTIYMIRFLTEMVGFWAGSLLSNRDTWGWGLTMSQSFGLLAVLPLVSALPFLYFMDEPTVASVLPVRDQLVGILKMLSLRATWQPLAFIVLYHTLHTYNAAWGNYLQVTYHFNAFEYGSMAAVGSSVGFGGVYFYQRFLLAGGHWHFVYAFASVVIALFSIANVILVFRLNEAMGIPPYWFALGDSAIMKFAYGVQYLPSAIMFTRVCPDGQEAVAYALLTGFANLAGGFASTISNALLGIWPVQLEDMQAGGVDGVWKLTLLTSCIRFLALPFIPWLLPNTVEDLDRLKQPQFISRLGGICALVVYVAGFLWVVVMSALAIMSPCLQIVGGHGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XQD4</accession>
    <name>A0A6G0XQD4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_002340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000025">
        <property type="protein sequence ID" value="KAF0742637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XQD4"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0742637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="86" mass="9945" checksum="A29105AC5D28D8FE" modified="2020-08-12" version="1">MVQFYLVGKPWISVLKAEHVRQVLNVSNFRRSNPIMKLSSKKELSLLLGQPWKLHRQWLPKPLDGKIALVFADRLILVSYCMAVVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XRD0</accession>
    <name>A0A6G0XRD0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_002171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000022">
        <property type="protein sequence ID" value="KAF0743114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XRD0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006330"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF57">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="1">
        <location>
            <begin position="212"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0743114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="394" mass="44767" checksum="E326D50A10F4F02F" modified="2020-08-12" version="1">MAPPRRSSYTIEAKRQVLALLEDHNDYEVSQLLNIPRRTVRGIAAKQFEIMAYDGSQLTKKINNGKREIFPDPDGFVAFMTKMKNEEKALSCVHNINWIKKHHHPWLLDYLSTKSADTGYMSLLRLLQRFCDSYGFSRQRPVLSKQTQEVLESVHMEFAESFHREFAAYSADTVYNVDETGMYYDMPPRVIWSIRGGQAKIAVGEKHGYSMTAALTIRADGTKLPIMYVIRGQPGGRIEKHELPTYPTGHAYAVQPKAWMDSRVWPMYLREVLGGVIAEPSAVLVDNFDAHVSEEGYRMVNEELGSHLCAIPPNATSVCQPLDVGIMAPFKKYLRRLWLAETFVEGDDDEDDEESPTSRVKRLVMIKCAIKAWDLITAEEVRASFAKAIPVQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XRD3</accession>
    <name>A0A6G0XRD3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_002088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000022">
        <property type="protein sequence ID" value="KAF0743028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XRD3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000593"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="1">
        <location>
            <begin position="55"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0743028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="239" mass="27963" checksum="42218E95661A7D26" modified="2020-08-12" version="1">MIRYVAPRSLGMDSGWSALIEKEQKHEMKNEMASSRRDAGALASWTKKEKDGLDNLKALFIHNVRPKNSTCGDYVEYLCVIENSRSGVTWEIHRRYSLFHYFRETMDELFETPHCHYCKEARKKMKELVFPAKKIFNTDEIILQRVVEFHAYIQGILKILSNSFYRHCKLVSVQAHIVMKRFLTSDMRRHDVLGSKEQTIYSVPLLLRELQLKDHAKRSPKLTLEPIVEQPAFSLTKAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XRH9</accession>
    <name>A0A6G0XRH9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Gamma tubulin complex component C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_002115</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000022">
        <property type="protein sequence ID" value="KAF0743057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015796"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF70">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="7">
        <location>
            <begin position="190"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="6">
        <location>
            <begin position="1020"/>
            <end position="1310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0743057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1316" mass="148333" checksum="7FAF89B2706850B4" modified="2020-08-12" version="1">MLDAMSAVPGYSHMQRDLWHEKDMEKFVDLFGALHHTKLHRTDNKLVRFDIRLNLPEIDDNPPDLIPNVLQAKRIPQSRQLRQPKPLEHYLMKGAASVGATGNDCDLLFSSQKTAIQISVPEKGNTNASTVDNTTAAPMKVWENLGPNKIEIAPRLRLGEHSPGSTSASTTLEGGSKELVSEVDLVRGVQKVLQGIETKFFQYDHHAMKFVVSSTFLKASPSFDTSSFLHVFAQMGTYISRLQTLSSHFRQSPLIGGRILQSMGISLHTFLASNHAYILSLHKKTLVSVWSATSTSRARMLGVARLFMCDDDTLWIGGNRRLIMTVIPRGIDMLNHVCRAIIQCQCSEHYTASLFIWLFVQISSPYFQALSLWIFLGELTDEQMEFMDQNTFRCLDCVADQRIILDSISEAGALLQVTREINTRVYYLSSFQWSPLQLITNLNHVQQYIDQHSDNLQTTRAAMEKYKKEQLEILADAIYDLKASRPRSETTDMQTNEDARRQLRRFQQQLQRRLLDEQIQETKSQEYRRRAQELLDDEATTRRDRESQLQIEHDKKRLIEIYDGLMADSERRHRKALWKQVRASRKLTAPSSLSNLFHMEIADWRQASNIDSQIRPQTDLNPGQLKHQRAIGAVETDERDLKNQSTIRVLQAPGGNSAENILRDNSIDEAIMPHTSVRVSQEPGGDGQTAESLIYQGEDSDENYLHSNIRLLNVPGGGGTDAFNTIYQGESLIANHINTTRVTQEPGGSGEAAIKAIYNGDLEQANAFGHTRILQEPGASGSSAENAIYRGQDEYRSDVPSVRVLQEPGGSGRSAANIIHQGGDEYVENSHIRIVQEPGGSGETVSNLLYGKALDEQDPFRATIRVTQAPGGDGSELSDTLYASFSKLGVSKSSVKILAPPGGGYDTVSKLVFGGLQEKAKTRLQDQKSNIRLEWKLFQDRTKQRLTYPSIEALQIDSTRLEGDFDQAILAYRALMDSDETIEYPPIEKLISFSIRQPILDQRAFVGSVTLSLLREHVHLMSHLGALHDLVLLNGGIWVERFMQEFTAGLDASTRVNWGVPGSLNDLLAAALDEANYNQTESSHLFAFGTTDELELLLANRTLVPPLQEVLRGIEPVYALPKVLEVVIPLPMLRVYTRIHSHLFQLKAIAYSMQSVRHTLRKYNVSSTSCHLMAHIQHHLCTTLVSHCFQSIAEEWHRFQKKVSDCNDTIDFKKHHNTFIMSIEHRCFLDPNTEQVHRNIQTCLDRVVHVVEVIQNNSTSASTLNRVLAHLLQNATDQQKEMSDLVQALRDDPSEAADELLRRLDFNDFYSPDQSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XRT8</accession>
    <name>A0A6G0XRT8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromatin target of PRMT1 protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_002143</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000022">
        <property type="protein sequence ID" value="KAF0743085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XRT8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009992"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025715">
        <property type="entry name" value="FoP_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13865">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01218">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Chromatin target of PRMT1 protein C-terminal" evidence="3">
        <location>
            <begin position="83"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="70"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0743085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="186" mass="19862" checksum="94429FDA57629766" modified="2020-08-12" version="1">MSGRGRGGRRVNASGRGGRGGGREAKSESASEKGRVIGYSSTPLSERFASLHAKPTAKITPAPAKALTKQVAARVQTNQRNKRQNTVNARRGIAPVPAPKAATPKPIAKRTPGGVRINLRGRGRGRGRGRGAGRGDRPPSAKPEELDMDMDAYWHEGGKGPDPKQAALDREMEQYWADKPSLPQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XSC6</accession>
    <name>A0A6G0XSC6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_001857</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000017">
        <property type="protein sequence ID" value="KAF0743383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XSC6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000708"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23011">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23011:SF28">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00103">
        <property type="entry name" value="CAMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="267"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="431"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="570"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="844"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0743383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1243" mass="139275" checksum="DE61F568C65DFC85" modified="2020-08-12" version="1">MERKSKHPIHLAALDEEDENDEPKAQDERQPVKLNSTATTTGAGKKRLQLTIKNVLMRAQVTKVLSQKNPTSVLPEAALPLNESVKLMQVSAQLPKLATPKPPPLTLNHTSSQTTNIWSNVVRKSTMQPNTEGSLQSANNDNEEYRKTSLRDILMSPKVKQYVNKVSTRSGSVKPLPQSAAMRHWSSSIGSRNNLPHEADDDHREASREAANEERKREASNPEYGRNLILAESCRAAFGRSAENRSNNDIQALKTWFQKTKLNTCTDFESLQTVELTLLCRRMKLHAYYANEVVFKQGEEGDALYIVFSGKVEVRVSQQVMGEFVEVVVCEIGKGEFFGERSLLNNEPRAATIVTKVPTELVSICRDDYNVMLKEDQQAFLAKASIAPPNRLSEVVAGNHATYLKILKKKPSARSKADLVTLATFLQTLKFFRGLPKTFVQELCTIIDLINVDANTTIFREGEVGKLFYVILSGSVDVKINAPDKRGGSGQAKLVNLGEGSHFGDLALIKKDGLRSATVVATEQCELLIISEKDYNSILKKLQKEDMQKRMELLDRIPIFQSVEWTSELMEELSYVLIEQRCAANTTVFKQGDKATQIYFITRGEVVISRVVTDPKSHNKYSVVVARLGPFNVFGDDAATGKNFNEVVLRTDTATASTPIEVLILTKYDVFNRLSRMARETMRTHTHQNKQPIVVFDQLYKTLKWEEYKRKVVQKEANLDRLQRRLGQKHIPSLKAKTPSTNKADLPPTELVEGNELLLLSPLKAQATPPPTNTLAGYTLHYNPDISTPKRIGLLEQAVENDANTAIDVLNEGNPIVYLNYLAARNMPPADSMSENFVFSLPSVSKNRQTSPKKKGALEPSTSSPSKRESLPQLLQGGFVVINLSNKELNPRSKQPAFRVIGLYATHDQAVVAANHVEAFENAYAYRSLPFKHEHPVEFFIVETGRHVIVPTNTDHMLSTTYCDEKMQEYLHDHGSLDKLATKRSPERGPASALSADAVASIMTDICGYIEPLDLSHSPPNTTMQKEKLLNLQDIEHNHMAVELKQPYNFACVSTLVVGDGSEPTLCVFRCFPTEAEANDYAETGFPKELSAQALLCVVPMYEWIYFEDATDWCLQMRKSQDRHNLALHKKELHAIQKTAASPLAVAAAKFNEAPQWLIELEQGQRLHHLICSHMGVKEKESEKALDDEGYSQKSSVGLEQKLESLQDILNAKHQNAAYGTTLQKMQKVQRFGHIMKLRLHKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XT46</accession>
    <name>A0A6G0XT46_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Anoctamin transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_001376</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XT46"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020907"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF73">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="666"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="710"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="778"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="7">
        <location>
            <begin position="255"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="842"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="862"/>
            <end position="877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0743718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="889" mass="102247" checksum="F7E7C1C631ABB49F" modified="2020-08-12" version="1">MMEDEVHLEEGKNIQNQAHDGIDTAMLASNSASLPYSKSPRHVGAVGKYRYLTSSDLKNSSAKAPYDFAVIAHRSVQQTPQGWWFWPFNTAERLGFRRLCMVSSPLLEDGEDEHRRIVEKLCAQGLAIDIIDGGHSTGEMTSDFFILLIRASDDVTRAYAKKFRRKLWVNHGGVCDMPQDFTDGPEGRAISPAERIEIVQYIVEQRAQLTKADKWIYDMFPVHDEKMTNHLVGTYITSCPGALERHQRAFVDSLRHNFGEKVAYYFSFMLFYNKALLPLALFGLAMQILHNFISTVTYMRVLPFWGLGVSVGWSFFYLKAWDRENARMQFDWNNKLNVKQIEHPNPVFRGKDVVNALTGETTKYYAPWRRYPIYFIALVFMVFQTVIMLMLVALWVSIYEMLKDKYKEGGFLSKQWCLILLEGIVFGFFVDVIQWNLVVTNMGRLFTRWENHPTEEAFERSLIRKLFVMDFLNYYTWFFSLAFIYVVPSLGDALTNYFNTLFFHDAPNCCFGPYLKEVGPQGFECNRCPGGDASTTCSPCSGWFTFDVHHVNLSAMFVTPIVVTQLLNILINTVMPLVSKWRQERLRAAADSDAQKRVLETGSMKIIGNLDYDQSAHFGNKDQSRYLEYTPAEIETLNQKAREILFESEQAHYDPYNDFHQMSVQFGFTVMFSILWPLMPLACMLINCLKVRTDGYRLCRTLKRPFPRKANGIGAWRGIFVIFAYIAVVVNVLLICMSTGSMEFYSDTCIKDYEFNLELEHKTLADFVMGPNFYCLNITVRLIVILLLEHVLLVVVYFFMAKVPGIPKHLQAVMDAREHKFKKMLEACEAVLPLAQEAVAVKSPQADKTPPPPLTTQKSKSPLKEKLDTMKRRESMNPDKAALARQWSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XTD3</accession>
    <name>A0A6G0XTD3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_001517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XTD3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007307"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026174531" evidence="1">
        <location>
            <begin position="26"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0743874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="244" mass="25407" checksum="652F3125E65857C6" modified="2020-08-12" version="1">MQPIRSVYLVLAMAILAASAPSGGGLGGFAGFPVGVPGTSFFSNANANSAAKANNVQAADNHFNNHVDSNAGNQALQEDVVFVKNNANTVANDNGFQNAVSKNDAFNHNNAKQASNGAVFFGRRRQLGADTECVGCGGVGIGGIPPSGFDNAKQAVNAANGANYFNQANQGRDTNAHQGFNNKRVEKHNLDQESFGNVNANSNAGANALSKGNFFNKNQALAARGVAQNNGLFYRRMLGASRAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XTH4</accession>
    <name>A0A6G0XTH4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_001556</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XTH4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004460"/>
    <dbReference type="OrthoDB" id="3427at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026273468" description="GOLD domain-containing protein" evidence="10">
        <location>
            <begin position="20"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="11">
        <location>
            <begin position="29"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0743914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="215" mass="24457" checksum="D98CE8726A74DAAD" modified="2020-08-12" version="1">MVRAIQVVLGFVCASVVHAAHFMITPDDHKCFHMDIPDGTTFRAEYESPDTNEALKTVMKIYEPAAAEEGELNQTPSISQTLNEKGAIAFTTTKSGEHWACISIDTNKYVVPDTTKMKFKLKLRFGASNEEYANLAKKEQMNELELEVMKLRDRVKAIQKQQDYAQEKGDKFRSSSENNNSRAMWVSVIQIVVLLVAGIWQVHHLQTYFQKKKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XUN6</accession>
    <name>A0A6G0XUN6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_000856</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XUN6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016823"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052842">
        <property type="entry name" value="ER_Co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45184">
        <property type="entry name" value="DNAJ PROTEIN ERDJ3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45184:SF1">
        <property type="entry name" value="DNAJ PROTEIN ERDJ3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026149396" description="J domain-containing protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="30"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0744370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="438" mass="48363" checksum="12C0013836FAAD10" modified="2020-08-12" version="1">MPLGRSFRLAVILLLVLLSVDNVDAKKKTDYYKILGVPKNFNDRQLKKAYRTLALKYHPDKVEESEREKAQEKFLEISQAYEVLSDPKKREEYDLYGADGPPNGGGPRGGPGGFHHGGPGFDPFEMFNQFFGQQGGGRRGQQGGGRAQEFHFSGMDGFGGFGGFGGFGGGGQQRPPPPPASLYPKGASNIATLSPTKFPDANSKNEWLVQFYSNQDKKCIKFKDAMESIAKDLRGRVKVGAVDCDKHRPFCQQHGVENLPSFVHIWKDNVSPLYDGPLDEFQVYNFAFEKYLARYKAKRDAGEVDELHGGNQGKLCNLGKEADPATSAFCAVFVLPTADRAKWMDTIQAVAQKYKSQKGIHMVWVDEPGQIKALRRLQSPKGPTLLLIRRKASAFSRLRVGTHASSTFDVESLSATIERAIGGDLAMENVDAATVEFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XUY7</accession>
    <name>A0A6G0XUY7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_000790</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XUY7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013473"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015470"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038039">
        <property type="term" value="C:G protein-coupled receptor heterodimeric complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004965">
        <property type="term" value="F:G protein-coupled GABA receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15047">
        <property type="entry name" value="7tmC_GABA-B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002455">
        <property type="entry name" value="GPCR3_GABA-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519:SF20">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 156-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519">
        <property type="entry name" value="GABA-B RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="588"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="623"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="655"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="697"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="746"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="782"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="812"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="10">
        <location>
            <begin position="588"/>
            <end position="838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0744302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="900" mass="99133" checksum="519467CAB748C9A1" modified="2020-08-12" version="1">MTLPDATDAVRRTCLDAQWVASTAANLKIDPKARDPSTNRKLYPWLRPTLPTARFRISDPRFTSSAYSSNCVSSTYIYGVGASIDAAGRVLQRGKIEGTLVAEWAGWPSHQLTSYVNSILVQEVLGYDVSFAIIDYSPGATERMSTAGQGLCTPTHVNPEIWSEARIKILNVYANETTSGIIGYWGRTGHYTLQANVNIALQGKAANFSKPLSADFWREYAISDDLINFYSIDKHNRSLIANKEFCPDDTMGCKNGCSKSFACTLAERAGKTCMLVLFMRSSYDSGYIQAFISNNNVPAYFCFVGDSQLESYVVDTMDRNGTLTFYHYEPHMFHFDHPGQFARIFWPLPNPAVVASSTSSFGERGYGNETTNPVNVDFPQQDLAKYYSNVLHSDAFLTRYLDRLRLTQLDINTMLQTMSALQKNTSNPDFVAACSWVKANYNTWQAWLDPLPLCDLIKHINYTLSGCDGSSRVVRFQWAVPDPTNSSLPYVCDGGHPLPRPLSTSRSCAWLETHREIWMSWAVHLPTCDASFYSYTVSPCRFDSTRLVTYGWFMTQGLSSMSAECVGGVSLPANEIIPCDYVPGGSQIYIGIAIFASSVAVGLVVLTALVVRHRENPVIKRSQWPLLVSMLGGGLLLCCYVLLGGGLPSSEMCGVRLLLGSLGYTLVFGSLFVKSLRVFWVFYHKPLKRKVVPLSRVVHIFMVVIAIDCGIVLLGLAVDYPHPLSTNSTTNGGSVVGNLQCDSSDVIFLALSIFYKGLITCWGLYIAFLIRHADSDFQETVWIFASSCVVVGGSTVMLALAFVGTLSVATTYAFQSVVILLCTIAVMALMLVPKFRKLSGITPLTDEQVSGTSTASSTSWRVFRQKSNSKSESWAVPVATAKAVSTFRTPQLAKASQLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XVR2</accession>
    <name>A0A6G0XVR2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PWWP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_001051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XVR2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009461"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05162">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWWP" evidence="1">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="PWWP" evidence="1">
        <location>
            <begin position="195"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0744582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="229" mass="26295" checksum="78F750E67800C281" modified="2020-08-12" version="1">MVLVAVNNVAWGLLKGYPWWPLYVIDPHKLRPNLYHLGSAHRDILEKAKKESNKYRIVYYFGSHDFGLHSSTQLKVWGGKDHPVLMAGYPSSSCLEMDIIQLFSHAIREAEDYLITDKKERTLPYMIPSDLDPSIEPPSAVVIDLVDSDEDDDVPFQEPTKEMQTFMPAPPSISRPSQSDRFDIADSHHTPDVPYNSLAWVRPRGYPWWPVYVCDPDLLRPDLHHLATM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XVT2</accession>
    <name>A0A6G0XVT2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Ae201684_000971</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XVT2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012381"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
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    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
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        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
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    <sequence length="793" mass="91124" checksum="099A8B71771A81F4" modified="2020-08-12" version="1">MVREDETPAEMWKTLISNYETKEWSKTIHVLRRLCQLRYEPKADMLKHISKVRSTIRELNDMGKTINEQETVEWILISLPDSGPEDFNAFINHLKPTPQQEVRLKTLISALLNEEVKRSERARIRRHERSKPTDFKRPRLEVQRDSPIMSNEINALHSRKNTPAAQNTTNLSEQWCFICRKRGDHVAQDHPDFDPNHGKGNQRRVPKTSRTKRRKESSDRSDSASDNEATYDINAILQDDGKPEKETHWTLDNCATGHVTRLKGVINTWEGTAQLVLPNQSKIQGHVGHVTLQLQSNGQWSTLVLRNVTFEPSLYKNLISHVRLLESGFRLLKQDMIETIYKNDTTQLELRFAMRNNLYVLTGAETTRINAMSTVLTGPKVQPSSNSNDKPDDGLSNNLQRHDQDQSDTKHRHHHHTKATDEKLVAWHNKLNHTDMNQVAKIIKPIMIPGVDAATTEHVCSGCAQGQAKRVSFRHTHHYVAPRPLESLNGDLRGPVRPQTINHEVYTSMFIDQASRYIFGQLLKTKADAILHLNDVTTKLDNQLPDSRISNLYTDGGGEYASSTFRAACQSRGITQKFTNTETPEENHLAEKTNEHVFNKVRIYMTLSGLPSNLWGFCFQYVIHVYNNTPQELLNQRTPYEVLFNKPSRLYMLKTFGCLAYKYIPKSQRPTKLTNPAIPCIFLGYAEEQLGYKLWDPKTRTITVSRSVKFDETKLHNTAMFTNEAFSHGRLSIPNYHKFKDISSHEELAHNRFTDLASSEHNGTPYTPTTLDTRELKEQSRPKRRSNDQSDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XVU1</accession>
    <name>A0A6G0XVU1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_001234</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="Elicitin domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Elicitin_sf"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026056692" evidence="2">
        <location>
            <begin position="22"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="293" mass="32147" checksum="BD4D0B1AC9DE49D7" modified="2020-08-12" version="1">MKLTSLLSVVFAALVASPVAGRSCTKADWEAVEKATHESPLSAACAADMNMPLGDFFAHKQPTAEQNKAFDESSNCKELYAEMQAASIAQHCSELEVFKYVTWEMVVALMDVGAYPKTSTHCDRAAIKEAFSHLLLNNNLVACLTTTGLYSSVVTHKIPTVHELAIVANTTSCADFYDEAQALLKEQPHCTMEKGAKGRDIHAVESVSFSVFVQWMQVLTMIHTKHVVPTALSLALSMWEIQDHTSPTHPSQAIVIAQSVFTGAAMAFIGMFIFARWRRASEEARGLLRPSYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XXA2</accession>
    <name>A0A6G0XXA2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_000377</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
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            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019688"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="156"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="367"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="521"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="28"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1110"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="229"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="415"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="521"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="549"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="592"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="632"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0745351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1291" mass="143759" checksum="0FBC8558798FBD40" modified="2020-08-12" version="1">MPEVANVFARQEDAFSNCMSIISTTIAKQEEENQLKASVEEILQLRGDVKKLTDAINESKKMIHRLEKTQARLLEELDELRRENTEKDAMLERLLEQQEQHLDEYESHLKELDDRFDYVSKMRMEQKELQSRVEKQEKNYAELQFGVALLSKSIGDESDGAGSGASPIVAPVPLAPPIQRSRSGRKLPMAKSGSATLLNGRKLSKAVTRLPPSDVLFPTTGRHPPLEHYTTSYIQPTSGTATPTEVFPATRKPSGDALAQVASELLVRQASSIFRPLSPPPKTPLLDEPTPLSPKLSSVDLLSFDLQPSSSRDVELERRPSADVNVATNFYALSSSQVEEISTSNPSATASLQCSREDIQVYNKDSIEMTEPLPTQPATPTNSRQSSERHMEISAPAPLNPDDSPSQEFVRQESQESSGQSTSESHQQDALEPNRSELIPQASPDMETPKLATTTPPITQRVEESPRVFDDHSPSPRLDETLGTTLLVKETPQLMQKAPPQHHEVLPHEDTTTIQTHNIQSEIESPSQSQLQELPSTRSVESKSDLSEIHSTTTTTNKTPAQESHQKQQLQRQPTSSEQNPHKKSSTEQKKANTPKAAKATTKTAATPANSKQETKREPVTRKKSAKAINASEDTVVTPISSSREESTQLVAATSSNKATGIRSSEEYHYLWHWAYSNIVVLSRMHGKHNVQQLFTDEKKDTVASRVRQMEETVGGMRAMVDSLHDHLGTIHNVKQNIETIQTTTMELHDGMAKMQRASEETSNTTQSLTNQLQKLDSFVQELVQGYSTAMNKTPPKPATPRPVEPTVTLAEFQNFQSHVDQLETTVAQLDPFMAEVRSARDQAKKELQAVVASQTSQAGSLEKDLIKTNDDMRKRSQEHKKELEELTVYANDVVDRLYVWIQFFAETLHVAFANESPASGTIHRLLIAVFRGKYTSLSAKLLLLADQHAGLPIEAPARAVCGHADGLADVKDRDVDAYLSSGFPLLATLVSALDKWEERSLAIPMLRLVRETLVEAKAITCVNPFQQRFSAINAKMNALNTQVSGNFTSVIMEIKMRVAETKAAVGVHSTEIRELNHLHTAVKTVTTKVDYVVSNTQMMIVEDDLKKIVTKLNTERHQLKTDLEAAIKQIANSSVEKEKELEREARRSENSRVCMDFLDREELGFVQESMQDAMSRLEREVVSHDEFVVLADRLKRKPDANDIRTYIQQKIAGLKLQQGEASHEAPLLGSVPVRCISCQNVVAAKLEPHAQQQPSKKEAKDVLPFTTSSVRHVQKQKLEAMLKAKAAMDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W3J0</accession>
    <name>A0A6G0W3J0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_019086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000387">
        <property type="protein sequence ID" value="KAF0721553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W3J0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006197"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0721553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="103" mass="10946" checksum="15523B3EA792B093" modified="2020-08-12" version="1">MRAVVAAEAMKRGSKSRKGDERTAAPTTTAPPPPPPTPYSFDVCFKHHSCGLDGKRGERDRGISPIIPALDTKRKCGDGIRGVRAGSAWGRGPGECENCNAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W4A5</accession>
    <name>A0A6G0W4A5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_018842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000361">
        <property type="protein sequence ID" value="KAF0721855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W4A5"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0721855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="150" mass="16272" checksum="372E3D3A0FC09A33" modified="2020-08-12" version="1">MSPNGLPSTIDDGGTWSFFVNFHEVVPIVVCVAMAGAASLAVQGGSKRELTTAGRIRLWAARRAVVAADKTAVPVKVAPRNRPRHTWPQLHTRPRSASNIMAVDWKASEANATMASVRALHGRRGRRIVPTVDKHPLNLESIDVHISLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W4Q7</accession>
    <name>A0A6G0W4Q7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_018701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000349">
        <property type="protein sequence ID" value="KAF0722064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W4Q7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018227"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0722064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="204" mass="23099" checksum="1AFF69C919A6A232" modified="2020-08-12" version="1">MMIPSKRFTAAHKHLLAMKMCSEETAHTFSPSMSSEWRSKYLRKLHISKQGESPPPQPTTPAPSTSFSAPIMIPSTSDRNSWGRDERTSPVLSWERRSSFSMSTPSPPPPMDELDLDEVSMFPMGSPDEHDESASEQDEDEKQEDCVAFYDRHPADLTRTSDPMPIAGSRVRRRGFIPPHQLVQRDCFSLGVQHQFRKRPTAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W4Y8</accession>
    <name>A0A6G0W4Y8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_018692</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000349">
        <property type="protein sequence ID" value="KAF0722055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W4Y8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018236"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20908">
        <property type="entry name" value="SUF4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23215:SF0">
        <property type="entry name" value="BUB3-INTERACTING AND GLEBS MOTIF-CONTAINING PROTEIN ZNF207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23215">
        <property type="entry name" value="ZINC FINGER PROTEIN 207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0722055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="238" mass="26480" checksum="C041619C53120B9F" modified="2020-08-12" version="1">MGKKKKRDDGIDEPKIARIYCYYCDRVFEDEKVLIMHQKARHFKCNYCNKKLSTAGGMVVHVAQVHHETILHVPNAKPGRESVDVEVYGMEGVPGYSSAKSSIMEDPLKRMRVDGAAPMLYPPIMAPMPGYPYQFPAPVPPRPPFPIGMVPPPMLAPGAAPPMIPFPPGMKPPPPLNPQTLPQTTPSVLPPTTPVEEEPPMQFTMAPPQPGIVLIFPEDDVSMEEKRAFLPKFRRKAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W608</accession>
    <name>A0A6G0W608_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_019094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000390">
        <property type="protein sequence ID" value="KAF0721524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W608"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007499"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF37">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0721524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="216" mass="24256" checksum="ADBB7259AB5EB199" modified="2020-08-12" version="1">MECATPAVERPTSDGRDEERRKKKEEAVLGILMSKVSDAQARGLTAEETAQLESLLSKHVDVFREDLGNDPPVKVEPLKVRVKPDSKPVKCGMRRYPPAHLEYMREHVAALEANGMVYKNNRATWAAAPRIVPKRDAGALRMTIDSRPINACTEPMPWPMPNLDSAVACLVGTKAYFTLDWTKGYWQLPLHADSQEFFSFMTPFGVYTPTRVLMGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W7I0</accession>
    <name>A0A6G0W7I0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aminodeoxychorismate synthase</fullName>
            <ecNumber evidence="4">2.6.1.85</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Para-aminobenzoate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">p-aminobenzoic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_018683</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:11672"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58406"/>
            <dbReference type="EC" id="2.6.1.85"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 4-aminobenzoate from chorismate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the anthranilate synthase component I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.85" evidence="4"/>
    <dbReference type="EMBL" id="VJMJ01000347">
        <property type="protein sequence ID" value="KAF0722120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W7I0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002149"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00149"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046820">
        <property type="term" value="F:4-amino-4-deoxychorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008153">
        <property type="term" value="P:4-aminobenzoate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="entry name" value="Anthranilate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005802">
        <property type="entry name" value="ADC_synth_comp_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00553">
        <property type="entry name" value="pabB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="AMINOBENZOATE/ANTHRANILATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236:SF18">
        <property type="entry name" value="AMINODEOXYCHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="ADC synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="10">
        <location>
            <begin position="11"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Anthranilate synthase component I N-terminal" evidence="12">
        <location>
            <begin position="263"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate-utilising enzyme C-terminal" evidence="11">
        <location>
            <begin position="459"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0722120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="743" mass="81589" checksum="A37CFBC8D5A1A350" modified="2020-08-12" version="1">MVSQPALVQTLLLDNYDSYTYNLYQMLAQVNGLEPVVFFNDAFGGDWNAAFAAFLERVEQVKLLHPHNEVHINIVLSPGPGTPTNASDFGLCAAAVLQSPTIPILGVCLGHQGMAHLYGGQVGPAPQVMHGMLSRIAVKSPNDAFFHEIPKTFDVVRYHSLIATNLPTDKLTVLATTTDGDIIMAFKHKQLNHYGVQFHPEAVCSQFGFQMLQNFRDLTTKAPCSSCKLLHTSSVPRMIVQPDKKKDKAYFTVVAAVEVAVDATVVFDKLFGKSRHAFWLDSSSGGGPNARFSYMGDASGPLSKYVAYDKWNETVTTSQGEELAKTHILDYLRGQLDHFAVEEATMDLPFDFCGGFVGYFGYEVLGVDSKSDLRVHPPDDMKVPDASFILADRVIVLDAQEPTVYLVAVTNDANKQVTQAWVDETKLHLQQLSLKHIDSTEQKPVDSSTPIIFTPSRTRATYEANIATILNKIQVGDTYEVCLTNQLVAEMHLESPLNFYKTLRRLNPAPFAGFLSTPDFAICSSSPERFISIDKSGAIESKPIKGTRKRCLDDLAEDANIAAELQSCVKDRAENMMIADLVRNDFGRVCVAGSIHIPKLMQVETFATVHQLVTTVRGQLRSDCNVVDAIHATFPGGSMTGAPKKRTMEIIRDVETHPRGVYSGALGYLSLNGAADLNIVIRTAVVTKNHITIGSGGAIVALSDVDDEYDEMLLKTKALRAALAAYCQRPVEVDVSRSFYEDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W801</accession>
    <name>A0A6G0W801_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_017818</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000313">
        <property type="protein sequence ID" value="KAF0723199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W801"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0723199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="78" mass="8647" checksum="CA2990AB00FB707D" modified="2020-08-12" version="1">MTVSVVLVLAYILAVCVLLAMGAYAYRSWKARQEMILAKIRERNARGSDEMLPDNHSLLKPSSPATTTSNHSNNQTQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W8P8</accession>
    <name>A0A6G0W8P8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_017573</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000303">
        <property type="protein sequence ID" value="KAF0723539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W8P8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007522"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF28">
        <property type="entry name" value="TRANSPOSON-ENCODED PROTEIN WITH RIBONUCLEASE H-LIKE AND RETROVIRUS ZINC FINGER-LIKE DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="38"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="317"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0723539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="416" mass="47919" checksum="8F6C64C72DC06DE6" modified="2020-08-12" version="1">MGHLPLQTIKLCAKEHVGIPKEFVAPTTQCVACVGAKMAALPKPKFATRKWKLGELIHSDLKGPMRTASNNGYLYMATYIEEVSGFVWTKILKVKDEQELQAWMETQSGFKIKCLRSDGDGEYTSGDFEAYLKEQGIKHETTAPDSPHQNGKAERMNRTLFEMALAMMLHSGMEKRWWAEAVSTAAYIRNRVVNSNDDEKTPQEILFGQKPNYSNWKVWGCICYRLLPYQSKRDKLKAKASKCIFLGYSKTKKAYRLYDIETMKVVHAITVTFFETRFWKDEPGDDYDDSSDEESDDGFDNHNESVSMPSNTPDETSPASSEASSASQQSYNLRNIPRDTRGHILPDFRRSLSLDELLEESNRMRRFNEAERQRRVERRQQSCLPPLPPLQNSTILRRSTRETRRPSRYMRGGRYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W9G3</accession>
    <name>A0A6G0W9G3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SEA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_017638</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000305">
        <property type="protein sequence ID" value="KAF0723484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W9G3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016255"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026066215" description="SEA domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0723484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="436" mass="45317" checksum="8021740291C595DE" modified="2020-08-12" version="1">MRSLALIVLFVCLVHVVAAHTADQIAVQQAGSPIANTLRKLIPAKGGKPGGGGGGGSAPKPAPAPAPAPKPAPAPAPAPAPKPAPAPAPAPAPAPASRPSPPSAPSPAVRPPPAPPVPRPAGVPSPVPYRPVTPVVYAQPTVVRPVVVAPVGYVYYPVYYPPVYVVRPVIIIPPVYWTTNACYQNYCYYDYNRCLNFYGDACFCYPGLLRCLQLSCFTYYQPAYDQCGQDLRKPSRCVLSCQPAPYAIPAVAAGSVGSAGNISNSSAIAEPSKIQYSVVAVVLIQGLNQSTMDDALYDFAGAVAKSVEPVNPGVIRDNVTLTYRGVIINSTNFLEVTIGVATPSVEVMNATDLRFQGMMYGNVTNNTLSQDLKANNVLFNESQLSFDTIKSNVFVANEDGATTAPSAASTLAPAQSGVVSTGLAAIALVFSALALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W9V2</accession>
    <name>A0A6G0W9V2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_017250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000290">
        <property type="protein sequence ID" value="KAF0723977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W9V2"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0723977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="39684" checksum="ED505B4201BEC8BD" modified="2020-08-12" version="1">MFKLFKKRADTTPPPPPNQSEMEEEIPSSPRGKLTEDLPSDDDVVCVLANYVGVLVLQGATEKRQIRYAMEIVCPVSRRKSECVKRFNQYYDVRQKLLQYMKQSCVCKKCATVERAIRAQPFPSRRIFTTMAHVKSRGIPLEGFLQRVIDTALNWEGCKKTQQGFADIVNQFIGAPVGGYSKADAATTTLDFRSSIRGLMVVRHIESDAPLSDTILQACKEDEEEQKDDSDVVSKPPEEAKPANGENSTPPEDVELVNSEVFIPLEDEKAGKSDVSSRLEEANPTNTDVINPPKEAESAHDDICSQSEEIQPAIEDVVPVTLPTEDIRAEEMEASVEIPANADDVVVEDERVEFEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WAD2</accession>
    <name>A0A6G0WAD2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_017092</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000278">
        <property type="protein sequence ID" value="KAF0724194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WAD2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020783"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31973:SF187">
        <property type="entry name" value="MUTATOR TRANSPOSASE MUDRA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31973">
        <property type="entry name" value="POLYPROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="6">
        <location>
            <begin position="385"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="5">
        <location>
            <begin position="494"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0724194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="512" mass="57785" checksum="13CDF03EFE3A2C83" modified="2020-08-12" version="1">MSHAMFFEVRILKSKKKNVHGYFVSSFVLEHHGCTGHSKPTCRQISEVQAARAAVTANPKTPALSLISQIQQTNAMTCGKTMMYRAQAAIREENLGEYEENFKKLPSLLETFCQQNPGSHQVFECDHEGRYKRAFLSNPIVSRHMQHGQHGNYREIMLILVGCTGNNTNIVLAVALCKSEDEENCRWFLENAKKAGIKFDGVPVFSDRGRGLLSAFEGSDLGCIVRYCTRHIVGNILKTFSGCVPPDLKTMVYRIQAADTREEFASHLDNLAHTHANIAKYIEDIPADRWLMYAAVVKSTKMYGWRTTNFVESANGAAIPSRLKFPFNFSRITWTSLWIKHLSVKNKAKKNAIKEQQKLAGTFTVHRKTSSVAFVRSSRGCPVQHRVDLDLKMCTCSYMQQMGLPCRHFIAALIKCERPHELYDACDTCYLVKNFLMGYGYGSQDGVELMLDEKIVPRNVLPPLKTLNTVGRTKTKRIRSHQELPVANSSTKLRKCTLCGEMGHNKRSCANN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WAF0</accession>
    <name>A0A6G0WAF0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_017036</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000276">
        <property type="protein sequence ID" value="KAF0724223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WAF0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005840"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0724223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="224" mass="25237" checksum="2755EA464C46D845" modified="2020-08-12" version="1">MSSGLPPANAWDANNLAARYDRYRIDLAKISEAPSEEFDLRIAGDAYGTPECFRPLPPSGPGYPLHVDFVALGRKLKGLRGLLLEGDFDLAYAASACLDIILAMRPFAMDNARWCRYIDEHHEMDLAATRGSRNRHGEVRTPKGVVPVAPLLGETALEYAAVWFLKLANDPNQVQNKLRDYTHVLEDLANYAKTRHRGPRLHFYVVRWLLAVRSHHYSEVADLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WAK2</accession>
    <name>A0A6G0WAK2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP synthase mitochondrial F1 complex assembly factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_016932</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000272">
        <property type="protein sequence ID" value="KAF0724391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WAK2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020727"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010591">
        <property type="entry name" value="ATP11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13126:SF0">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13126">
        <property type="entry name" value="CHAPERONE ATP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06644">
        <property type="entry name" value="ATP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0724391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="22994" checksum="0703108D5E606EEE" modified="2020-08-12" version="1">MLVARWGRRAMSTGGFHFPSPRSLQSLVKLDELEKEAPDAIRRIWNDYHDDKTDAMGRVLTQNEFRTLVDRAKKCAFFVFPVYRVNKDTNEEGYFTVLSQFQDKCFLLTTLDAYRENPAQAPPCLTVSIFDDLVSSKELALIRGDVANLLDKDEASKLLDSLIQRYVNDAHYSTVESFNLKPQEFSFDAYLEECKKLNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WAQ0</accession>
    <name>A0A6G0WAQ0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA-splicing endonuclease subunit Sen54 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_016995</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEN54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000273">
        <property type="protein sequence ID" value="KAF0724333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WAQ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021471"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024337">
        <property type="entry name" value="tRNA_splic_suSen54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024336">
        <property type="entry name" value="tRNA_splic_suSen54_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21027">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21027:SF1">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12928">
        <property type="entry name" value="tRNA_int_end_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA-splicing endonuclease subunit Sen54 N-terminal" evidence="3">
        <location>
            <begin position="27"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0724333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="214" mass="23370" checksum="530874DA24CFE77F" modified="2020-08-12" version="1">MAQSGANVGGAAPALTTYYADLDRSETNSVKTRSVGVLHVETGLTNVTKQRGKAMFNVGHVKANTLHLYPEEAYCLAHRGVLDIFTASTSATALSLREISDLLHVHVSVECRQVYCFLKERKFIPRRHRDGHNGVDIPRVSSATQLFIAYDVYAPGAKKSDQPLYCAVVFRMQDPMPSTDSLSVLCKGTDMPVKLFICDGEGSVLSMEVKDGMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WBW6</accession>
    <name>A0A6G0WBW6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Small nuclear ribonucleoprotein Sm D3</fullName>
            <shortName evidence="9">Sm-D3</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">snRNP core protein D3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_016893</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the snRNP core protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000271">
        <property type="protein sequence ID" value="KAF0724413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WBW6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019171"/>
    <dbReference type="OrthoDB" id="6425924at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01721">
        <property type="entry name" value="Sm_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000002">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034099">
        <property type="entry name" value="SmD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="11"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0724413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="137" mass="14988" checksum="769C6A9FAD534B98" modified="2020-08-12" version="1">MAVTGKRGVGIPTILLHDGEGTIVTVEMKNGDLYRGYLDETEDNMNCLLKDAIRTDVRGITTHCEHVYLRGSQIVFIVFPDMLKHAPFFKRVKLWKKHRGSIPALGLGGGAHIGLGSGPRGQAGAIMRKNQARRLGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WC27</accession>
    <name>A0A6G0WC27_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="9">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_016581</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPP phosphatase family. PP-1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="9"/>
    <dbReference type="EMBL" id="VJMJ01000261">
        <property type="protein sequence ID" value="KAF0724832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WC27"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016411"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07414">
        <property type="entry name" value="MPP_PP1_PPKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000007">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF300">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="10">
        <location>
            <begin position="122"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0724832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="329" mass="37322" checksum="98210C6A9676281F" modified="2020-08-12" version="1">MAAALEPIDVDSIIDKLLSVRGARPGKQVTLMESEIRALCLHSREIFLSQPILVELEAPIKICGDIHGQYYDLLRLFEYGGFPPDANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFILRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPVAAIVDEKIFCMHGGLSPELSQMEQIKRFVRPTDVPDTGLLCDLLWSDPEKDILGWGENDRGVSFTFGPDIVSQFLKRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDESLMCSFQILKPAEKKQRFAYQGMPAAGTAPAAQRPATPPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WCD7</accession>
    <name>A0A6G0WCD7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sjoegren syndrome nuclear autoantigen 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_017317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000292">
        <property type="protein sequence ID" value="KAF0723937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WCD7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016097"/>
    <dbReference type="OrthoDB" id="295355at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033362">
        <property type="entry name" value="SSNA1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28661:SF1">
        <property type="entry name" value="MICROTUBULE NUCLEATION FACTOR SSNA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28661">
        <property type="entry name" value="SJOEGREN SYNDROME NUCLEAR AUTOANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="8"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0723937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="13041" checksum="631FEC5D829414E2" modified="2020-08-12" version="1">MAQQGASMQNYNNELVKCIEDLREKREEVNRNILKEEEEKAKIQKDLTVLTDRLSKINETLARKTQARNEYDRTIQETEAAYMKILESSQTLLHVLKRETVQLTKKKQTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WEK0</accession>
    <name>A0A6G0WEK0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Isocitrate dehydrogenase [NADP]</fullName>
            <ecNumber evidence="10">1.1.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Ae201684_015899</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="10 13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10 13">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="10"/>
    <dbReference type="EMBL" id="VJMJ01000235">
        <property type="protein sequence ID" value="KAF0725681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WEK0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021478"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006739">
        <property type="term" value="P:NADP+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000002">
        <property type="entry name" value="Isocitrate dehydrogenase [NADP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004790">
        <property type="entry name" value="Isocitrate_DH_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00127">
        <property type="entry name" value="nadp_idh_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006156">
        <property type="entry name" value="PRK08299.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822:SF21">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NADP], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822">
        <property type="entry name" value="NADP-SPECIFIC ISOCITRATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000108">
        <property type="entry name" value="IDH_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="6 10 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 10 13" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 14" id="KW-0521">NADP</keyword>
    <keyword evidence="8 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="15">
        <location>
            <begin position="22"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="88"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="107"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="322"/>
            <end position="327"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="11">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="11">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF0725681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="424" mass="47415" checksum="F01AB7E051F41AC0" modified="2020-08-12" version="1">MLAKAIARRSFSSAKKIAVTNPVVDLDGDEMTRVIWDQIKAKFIHPNLDLKIEYFDLGLPHRDATNDQVTIDAAHAIKEFNVGIKCATITPDEERVKEFKLKKMWKSPNGTIRNILNGTVFREPIVISNVPRLVPGWKKPIVVGRHAFGDQYKCTDFVAPGPGKFEMTFTPADGGKPQSWEVYDYKGPGVGLAMYNTDESIYAFAHSCLAFALTKQQDLYLSTKNTILKKYDGRFKDIFEEVYQNEYKSKYDAAGIRYTHRLIDDMVAQALKSDGGFVWACKNYDGDVQSDIVAQGYGSLGLMTSVLLAPDGKTVEAEAAHGTVTRHWREYQKGKATSTNPIASMYAWTRGLAQRGKLDGNQELIQFTHDWEAAVIETVEAGHMTKDLAICVHGTSNVTPDQYLTTEPFMDEVVKTLNAKRGIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WH43</accession>
    <name>A0A6G0WH43_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_015287</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000215">
        <property type="protein sequence ID" value="KAF0726473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WH43"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005320"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0726473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="406" mass="45948" checksum="23BABBD6F8BB2A04" modified="2020-08-12" version="1">MMARHDAFESSQDASQQALMSPDILQLICQFQPGLWEDMLSFLPLQGINHAFEITLAHMDDIQVVLMPWYNVYGLGRIPRLVAALPFMKFIVLAFSARVGDTQLLRALARTCKVDIVPRVGDLLTIAIDSNQVDVIASLECVGYTPEIHKKRLIDGIGDAVARGHMTMAQYLAYELNQVNLRALRASLNGNTQAKMSTNLKMIFATKNFEGLQWLLNIWTHLLPPTWMSRCRRECRLLALEHQAWHILVMLSTNDVNPAAKYDKDLILAAKLASLEAVHWLLSTAGVVVKYHHIVQAAKYFRSDNPNSSLLLERLLAMWLPTLTELESKVQCLDICMNEAVKSGHFEAVQMIWRMGASKSTLQRYGTPTTMSEFANLCVSNYGENNNLTSLHWSCDWWISIKETKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WIZ1</accession>
    <name>A0A6G0WIZ1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_014722</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000200">
        <property type="protein sequence ID" value="KAF0727193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WIZ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000107"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0727193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="117" mass="12768" checksum="6E6E523FB82487B0" modified="2020-08-12" version="1">MESAATCTKASGKVYTRLGGKGQRASDSDESRGDRDALCPEGHVLTVQVAKSALEFVLFVFHALDLLLELDLSCLKCAQSFLELLLRHILSSQRVVDGRGCEGYACLDDVFIHELHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJ68</accession>
    <name>A0A6G0WJ68_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycine zipper domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_014669</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000199">
        <property type="protein sequence ID" value="KAF0727252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJ68"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004204"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026061580" description="Glycine zipper domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0727252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="21117" checksum="63C67A08334E6F8E" modified="2020-08-12" version="1">MRFLAPLAVTACIAFAHDFSQDSPVMQALAHDDTDYAVSDNVYSALEAAEFAAVAAKKKGSRRRGAGKKSRGLGKKRSGFKKSKKHVVAEASSEGGEVNADFMGIGSAIGGKIGRFFGRRAGTKAGSYIGSKAGTAIGTSVASPPGGYVGDNVGGSVGGTVGGYVGEKVGGKVGSYGGGKFMDRAKSWVRRKFTGGRRRRLQLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJK3</accession>
    <name>A0A6G0WJK3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_014536</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000197">
        <property type="protein sequence ID" value="KAF0727423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJK3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010496"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="21"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="215"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="533"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="654"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0727423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="898" mass="103101" checksum="90199E7C6981983B" modified="2020-08-12" version="1">MKDMAVLSSDDEEYELRDGKNVIGSAQDKCDVVLQGPNVATLHSTLDVTQDGMLLTDLNTPVGTYLNGVRILQPEKIVHGDSITFGPTGKIYKLNMALTPSVTKSIASRASDIPPMFSTSMQASTSIEGNKRPSRVFTSYRNELSVDNSLRELVERQLNRRSKLSSSLMSSLPVISSLSPSHRNLLEREKLRLSQKLRDIHNVMLGHATINDTYLAANPDDDDELPELSEKPQAPLGGDEDEEDDDLPETVEQIPLQPKAPRPQRTALQQSAIDNRIHTHRIKCWSKTWRAWVLAVQARKQRLLDQKKNTAASKIQRLYASWRLRKQICNRLQRHLYLTKMLRDVAKLHKRYALQTWRAWTSEALIGMFQQHVSQTWWVRTANKKAFSEWKQHWRNMKDRKEHLSRVLRFLQTSTKLRAFLLWKTWRHEIETKAALAKVADEHNKNKQLVQTMATQSHAEATAWSEQAKEMSQHLQREATLKAEIEELTRKWQKLALVVKVDANVQTENAPSTKSSTLLSHTLLKTVVGEVKEKHLRAVIESLESELHTYQARETKLNDEIKQLLAARLRQSTDVDKLRDRMKQLQDTLAHQTNEFELTKSKHEAALKNAAERELVLKLQIAELEAAAQAKMSMAANTQTEENSDGDINAKLNAQKAQATIREAALLLKLQNQESAINKLKTNHAEQIAKAIQEASRTSAMELDRYRKLLEVAEQKFQSEQKQTIINANQVQTQWNNQIQDFLEEMVTQYDLRLLRVSNELEQLINDKMNGAQFRAASQLVGYAQEERLNQYKVLSELYDQLLQSELDNQVVAANMEWTQNGQFLHEMLLQRFHRLHQLHESLAQHSATMEHGLDSKKLEYAKFLAQTMHTRQTEYVTQAASIMHQIARAQAHRQQQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJR3</accession>
    <name>A0A6G0WJR3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_014506</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000194">
        <property type="protein sequence ID" value="KAF0727485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJR3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013726"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="77"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0727485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="239" mass="26992" checksum="1B73A054488E5CB6" modified="2020-08-12" version="1">MEVGGSSLVGRLVGIATSPAGHALGLASVAAYLTYVYVGDLTLWSLKDIGFVVAVAGVVFFHRYRIKGYIEHDPKRRILDQVTPAFPLDEIEYVQGEPISLGQSHIIAIMFFATWCKGSRAALIEFQRVFDTYGRDVKFIALTQEPKEELEAYEVHGQKASNYKPLREFRFAIGIEGGRLTKEYQLKHNVKTVPHVYLVGRDDTIFWHGHPVGLFEDATRRTLAFDFSKPTRSKRDKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJX9</accession>
    <name>A0A6G0WJX9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_014397</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000193">
        <property type="protein sequence ID" value="KAF0727569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJX9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009736"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43102:SF2">
        <property type="entry name" value="GAF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43102">
        <property type="entry name" value="SLR1143 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="5">
        <location>
            <begin position="264"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0727569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="666" mass="74541" checksum="2E7D68F6966D9ED0" modified="2020-08-12" version="1">MVRSLPLRNGFFSAPYISETEEAELLTWARTLVPSLNSPDSEWTYSHEKRGVTVSEDRQKGGLFYSIRGVTTVQSSLDDIMDMMISTSTHEFRSMMKMLLKDMSLDSAVIYQRDQNDSESLSIKWFALKNKSTMATSQDFCVLEYAGILSADTIGGDPSRMVGVCLYESIEQAECPSLFDSHKLERGSISKCGYLFRPTDEIGTIEAQFICSIRQPQGIRTTRRSNRATLQCWAESLANIQESVHTRRISRLLTTRDQPTWVSDHERSCCYLCLKTFTGIRRKHHCRACGEVICKKCSIINSVDLPTIGLTAMRVCKSCADGNKNGSTSTPSMSFDSEPPHDEIVLKKSHSTESTRPQKPQLPYSDYALTVPQKNAGPVPDSVGMAWLQQIAQRDPSKRDMVERLVTGFGLLEEGGAFPATPTSDAPPEDIYDLLCDLASQALDCKFAVVHIMDENRQWFKSKVTIRESDIGRDFSFCEYPVRKKKAIVVLDTWRDPRFEMNPFVTGPLQVRFLAGAPLFDLDGRCVGSVCVLDSKPRAHLPQAQVALMEKLAHLAMVSMQERREALSKKLSASMVLPRQVAPVSTRAYLPDSYNSNYRPTTSGDMVPLHSYRSTNSLVPARTSAAAAAHQLEQRKMQEQMMDLLHQSTITQQRVKQTAGLQSSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WK31</accession>
    <name>A0A6G0WK31_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_014447</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000193">
        <property type="protein sequence ID" value="KAF0727622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WK31"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020673"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16189:SF13">
        <property type="entry name" value="AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16189">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 104-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="460"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="38"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0727622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="489" mass="52989" checksum="1C2C570E38A8E6DB" modified="2020-08-12" version="1">MDAAPLVRARSRSRSADPPLNPLDATAMSVRPYGSIVAVAMTLNYMVGTGCFGLPYAFYAAGLGLTSIFLIVGFFGSLVTMNYTLETMARAEGVLSSAKASMPENRLTYRKIDFSVIGDLFAGSMGYNVVQTVLVFYCLGSLWSYASIFASSIASIFYTFFLHGSCDAYAADASAGCLEAYYISMAVFSVVAIALVLMDLGDQAAIQKFLSVYRIVAFFLMLLTLTIKLYHEGADVISARVSSRGEWAFNWHNFAVGFGPTLLALNCQYNMPDALQPLHADEKKNARVVTFTAMTISATIYLLLGILGAIAFDQINPLVTLMWSDFTGCGNGWTPCPSGQPTWLGWIVHIVVILFPVMNIASTYPLVGLTVGGNILTSLPKSWTAPLGPTRSRNLARLIAAVPPLILAAIFKKLDAIFTFAGYFGFALGLIIPCWLQVIGIKYCQRTYHSELAALTPFNMAYVSTLGFSTIFLYATFVLTVIAIASLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WK44</accession>
    <name>A0A6G0WK44_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ae201684_014443</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the GARS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000193">
        <property type="protein sequence ID" value="KAF0727618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WK44"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021616"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046084">
        <property type="term" value="P:adenine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08645">
        <property type="entry name" value="FMT_core_GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02196">
        <property type="entry name" value="PurM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000006">
        <property type="entry name" value="Phosphoribosylamine--glycine ligase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000006">
        <property type="entry name" value="phosphoribosylamine--glycine ligase, chloroplastic-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.170:FF:000013">
        <property type="entry name" value="Phosphoribosylamine-glycine ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000001">
        <property type="entry name" value="Phosphoribosylformylglycinamidine cyclo-ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000018">
        <property type="entry name" value="Trifunctional purine biosynthetic protein adenosine-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.600.10:FF:000001">
        <property type="entry name" value="Trifunctional purine biosynthetic protein adenosine-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.650.10:FF:000019">
        <property type="entry name" value="Trifunctional purine biosynthetic protein adenosine-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.170">
        <property type="entry name" value="Formyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="entry name" value="Phosphoribosylglycinamide synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="entry name" value="PurM-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00741">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00138">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01930">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004607">
        <property type="entry name" value="GART"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020559">
        <property type="entry name" value="PRibGlycinamide_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020562">
        <property type="entry name" value="PRibGlycinamide_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004733">
        <property type="entry name" value="PurM_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00877">
        <property type="entry name" value="purD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00878">
        <property type="entry name" value="purM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00639">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520:SF12">
        <property type="entry name" value="TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
        <property type="entry name" value="TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02843">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02844">
        <property type="entry name" value="GARS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01209">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="PurM N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00184">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-grasp" evidence="13">
        <location>
            <begin position="275"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF0727618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1141" mass="120964" checksum="6ED524E7FA8338CA" modified="2020-08-12" version="1">MTVVVTCGKPSTASEAAKGLKLLQDLQQQGLRIAVLGSLAWRDQIVQAKIPHIHITSVSEVEELIQTQIRLVVAFAPNASTSNEAELKEWGIGCHGFVRSAAWAYDKIAVVVDSEDFASTLEKVSQHGELALSLNDRKRLAQKAFRTFASLDSRASQIISAEVVQRNILLIGNGGREHALAWKMAQSPQAAHIYVAPGNGGTATTNDKISNVALSPDKPDDLIAFCKEKNVSLCVVGPEAPLVAGLADKMNAAGIPTFGPSFKASQLEGSKAFSKDFMARHNIPTAAYRNFTSYDDAVAYVKSIDHNVVIKASGIAAGKGVLIPTTKEETIEALKEVMVSKAFGSAGDEVVVEEFMTGEEVSLLAFCDGQRVVAMPGAQDHKRIFDNDQGPNTGGMGVYAPAPCFDATAQKKCVEIVENTVQALAKEGMPYVGVLFAGFMLTPQGPKIVEYNCRFGDPETEVVLPLLNSDLVEIFLACAEHRLDSSLVQWKNGAAATVVMASEGYPESYPKGRVITGTDAANALPDVTVFHAGTAIKDGALVTSGGRVLTVTATAPTMKGAIAKAYEGVSKIHFQGAQYRSDIGHKGLLRSCPKIKLGVLGSTRGSSLQPILDAIASGELNASVEIVVSDKKAAGILERARNHNIEVAAVATKGKSREEVDAEVTALLRAKKVDLVLCIGYMRILSGDFCNQWQGRVLNVHPSLLPDFAGGMDLAVHQAVLDAKKTVSGCTVHFITEEVDAGPIAVQLKCPVFPTDTAETLKARVQPLEGTAFLFAIRRHQVAMYMGKIPSDKAITYADAGVSIDAGNALVQRIKPACKSTVRVGCDADLGGFGGLFDLQAAGYDKDTVLVACTDGVGTKLKIAQLTGQHTTVGIDLVAMCVNDLLVQGAEPLFFLDYYACGALDVEAAAQVVEGIAEGCRQSICGLIGGETAEMPSMYHGGDYDLAGFCVGAVSKSKLLPVAVNAGDVVLGLLSAGLHSNGYSLVRKLVDVSGLSYESPCPWDVKSTLGANLLTPTRIYVKALLPLIKRGLVRAMAHITGGGLLENIPRVLVETDAVEIDCSSWTLPPVFGWLRSVGNLPDSEMSRTFNCGIGMVLIVSPEHVDEVSSHLASESVVHMGRVVRRADAASSQVVFHGALQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WKA7</accession>
    <name>A0A6G0WKA7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">NEDD8-activating enzyme E1 catalytic subunit</fullName>
            <ecNumber evidence="8 11">6.2.1.64</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_014296</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>ATP + [NEDD8 protein] + [E1 NEDD8-activating enzyme]-L-cysteine = AMP + diphosphate + [E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="6.2.1.64"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.64" evidence="8 11"/>
    <dbReference type="EMBL" id="VJMJ01000191">
        <property type="protein sequence ID" value="KAF0727669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WKA7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009146"/>
    <dbReference type="UniPathway" id="UPA00885"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01488">
        <property type="entry name" value="Uba3_RUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.520:FF:000001">
        <property type="entry name" value="NEDD8-activating enzyme E1 catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.520">
        <property type="entry name" value="Ubiquitin activating enzymes (Uba3). Chain: B, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.20">
        <property type="entry name" value="Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014929">
        <property type="entry name" value="E2-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023318">
        <property type="entry name" value="Ub_act_enz_dom_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030468">
        <property type="entry name" value="Uba3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF6">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08825">
        <property type="entry name" value="E2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01181">
        <property type="entry name" value="E2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="E2 binding" evidence="12">
        <location>
            <begin position="353"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0727669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="439" mass="48437" checksum="1611D0989B4B1CB1" modified="2020-08-12" version="1">MEVGRRRNERNWDLNRLLFRATPFGNETNEEMGLGEFVAGQATADFLKNEAKVLVLGAGGLGCEILKDLAFSGFTDIHVVDMDTIDVSNLNRQFLFRRADVGQPKATLAAKFINQRVHGVKVTPHYCNLKTLDASFYSSFKLVISGLDNIDARRYVNSVLVSLVEFDEDGDIDPSTVVPFIDGGTEGFKGQARVILPRITSCFECSLDAFPPPTSFPLCTIAETPRQPSHCISYASIVLWSKHFPDTKMDTDSPEHMQWVFKQAEARANQFNIPGVTYSLTLGVVKNIIPAVASTNAIISAMCVNEALKAMSYCSQTMNNYHMHMGTTGIYSHTFVYEKKATCGVCATKTHKIPFHPNTTLGDVIEQLKETFRLTKPALSSGKGNLFMPNPPALYEATKGNLDKPLSTLVDHDALLTITDPVYVGDMSLQVQVQFSTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WKH5</accession>
    <name>A0A6G0WKH5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_014221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000188">
        <property type="protein sequence ID" value="KAF0727784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WKH5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019138"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0727784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="333" mass="36988" checksum="24DD41ECF856F718" modified="2020-08-12" version="1">MTWCKDQAKRQHCTLFLSTLLEPFYLRRRRRNYTMSFNAGAKTSLLQYPANNRICGDSTRRRMMVRSGLKPVAGKFPTESSRSLPTSLQYQRTQSPPRSLQSQRPQTMPPIGSDSFAAAQYPPKAASFGPPARPSARQLPPQSPVNQPHGEMTISRSKPTAQQPVTKYNTAPAASTSVQRHRSTPDLHDSRVYQNNHNHNHSSTSSSSSSASSTRSAPGFVPLNSYPAKEGKPQAAYVMEDFDDIHDGGYSPSSHSIMEWHDSISDSIASVDGNSIRERAKLIRTLSKNLAVAHQPEEPLPIPITRTHNDMIPLLATRLSTPDDEYGSDEEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WKX9</accession>
    <name>A0A6G0WKX9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_014139</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Folate-biopterin transporter (TC 2.A.71) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000185">
        <property type="protein sequence ID" value="KAF0727911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WKX9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017196"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039309">
        <property type="entry name" value="BT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585">
        <property type="entry name" value="FOLATE-BIOPTERIN TRANSPORTER 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585:SF5">
        <property type="entry name" value="RNA-BINDING S4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03092">
        <property type="entry name" value="BT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="369"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="507"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="547"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0727911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="586" mass="65043" checksum="321FE59E25881BDE" modified="2020-08-12" version="1">MQSELNAGGGSRPKIYLLEEKDLTLTDRTATVDSINSAPDFFVVMDHKLSISSFSEYSDDLRPSIHYGALRPGGALNLLSLEAFGLLSQYAGVGILMGVFNALQYPLFQNYLHMEGYQSASYRVLISLGWSSKIFFGILSDCLPVFGYKRRPYMVLGWAMCGVCCLMMAISPFPDPYYGSKELKGIPTSNMTADQLKLINSAAPTSASFFIVLSMIGSLGYVMAIVAADAMVAQYAQREPAAIRGRVQTAIYFTRDSFTMVPMLVVAFCMNDYKYGGSFSWSIGPNVVYAGLTVPCFLAAYTAFALMVEEKVDHVHITEYMQNAWLLLQKRVVWQICAFKFFNGVFFGYQSTLNDPISSIWVKVQPLVATSFSILSQLFRVVAMFAIGKYALNWDWRWAIALSTILLVVFDTAWHFLAIWDIYRNQYFHSAMNSLEAFPSATLFLFGAYILVEVVEEGNEGLVYALLSTVANLASPLSTVVAKTVDSFFNARLADIQRDDSAVRWQVTYSFIMAAAFKLGSLAFLVLMPRQKAYVQVLKRTGSLSKLAGALVVVCFFMVYAYNLTTNLLSIYPSTSCLRIAGGKGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WLE8</accession>
    <name>A0A6G0WLE8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_013934</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000181">
        <property type="protein sequence ID" value="KAF0728106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WLE8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003436"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056520">
        <property type="entry name" value="ARM_KDM8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF105">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24472">
        <property type="entry name" value="ARM_KDM8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="8">
        <location>
            <begin position="264"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0728106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="403" mass="46102" checksum="06819F936C702BC9" modified="2020-08-12" version="1">MEEFLLERARTIIEASEWEKGKPFAEEAVHRIWDRLHLDKWNNVHPKSRLYFAEACKLLAECQLHTPGESREQQIQAAIQTLDTGLLMAGPYGRDLHSLMNGLVEEATSQLSTHGNEQPSRKRICPSRPLETLPWTQDNPLCTSLKRIPPPAIHEFLNEYMCNNQPVIITGFVLQSIELTWHVGAMDHWPAMGKTHEGSRSWADLDYLRRVAGMRTVPIEIGSSYLDDNWSQSLMPLKDFIDQYVLKPSSSSPRGYLAQHALFEQIPSLRKDILIPDYCALSLCDDDDNVDEVVVNAWFGPDETISPLHFDPSQNLLCQVVGSKYIRLYDKKYSDNLYPVKGLLSNTSQVQVEDVDETAFPLFSTTPYWECILGPGEMLYIPPKCWHYIKSLTVSFSVSCWWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WLH6</accession>
    <name>A0A6G0WLH6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="28">Histone-lysine N-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">Ae201684_013989</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26 27">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000181">
        <property type="protein sequence ID" value="KAF0728163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016675"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044666">
        <property type="term" value="C:MLL3/4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042800">
        <property type="term" value="F:histone H3K4 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05162">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10518">
        <property type="entry name" value="SET_SETD1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003889">
        <property type="entry name" value="FYrich_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003888">
        <property type="entry name" value="FYrich_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45888">
        <property type="entry name" value="HL01030P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45888:SF6">
        <property type="entry name" value="HL01030P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05965">
        <property type="entry name" value="FYRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05964">
        <property type="entry name" value="FYRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00541">
        <property type="entry name" value="FYRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51543">
        <property type="entry name" value="FYRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51542">
        <property type="entry name" value="FYRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13 17" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="15" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 18" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Bromo" evidence="20">
        <location>
            <begin position="824"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="21">
        <location>
            <begin position="1014"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="22">
        <location>
            <begin position="1017"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="21">
        <location>
            <begin position="1066"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="21">
        <location>
            <begin position="1154"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="25">
        <location>
            <begin position="1483"/>
            <end position="1588"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="23">
        <location>
            <begin position="1937"/>
            <end position="2055"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="24">
        <location>
            <begin position="2061"/>
            <end position="2077"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="82"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="236"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1425"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1595"/>
            <end position="1620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1893"/>
            <end position="1917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="271"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1425"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="1436"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1604"/>
            <end position="1618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1899"/>
            <end position="1914"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KAF0728163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="28">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2077" mass="235864" checksum="9E4B8D5A9855B585" modified="2020-08-12" version="1">MLRSCEECRQVVAQGDIAEWTCATCGGIFHGVCVRNKKRPKTWHCSGCQGKKQEKGLLVAEAVNKLIDEKEDTEDAWWAEMESPSHQLDDASSSDYEDIDSPLRHDQSKNGAEDSLSSDSLDIDSSGVCTRCGLISIPKIHVWNCVVCKKNTAHSLCNKQFDRKRYTCPSCTSRRSRITDSTQYVIKPLLKKIAESAVVLCDHCQGEFSMATLNMSKLPKGDWFCHHCDDHSPDIEDVATSSKRARESQSASPRPDKRAKSSTKSSKKSSDPTPLQRSNRSSSVDVALCSRCGGISGKDQKCRECRRVSKMGKAKKRERVPLRVAIPEPAEDIILDSGASVDLWSMHEMVGRTVIVYMATNGQWLSGRIAFFDPHTLLHRVQFLDDTEQWLPLYTMAHCASEQINVFVKLQPPHEGWWPGQLMRLSTVARQYINESSEKLVYLYGADNVCAWVSMSSVRCFDVFELEAKQESTTWLDAVDEAKEEIHLARETVEDAKETLRRDIEKRLGGKKWIGKKVEVMNFSHGAIYHGTITKFNPTTSEYWLDATDQDAAKWFLVNDDVHISLVVDCSYTDLSMQWYADPDAVLQDTHKTLTTSSEKNDTRCIKCLFPLQSEVLLPCTKCEKLFHRSCVDCPQDAYPLLDKDGTVLIEDIHPPFICPDCSVCDGCDATSSDTWHRWKLPLTPVTLCTGCIGQYIEHSYCPVCHKTFGAFDFCTDAIQCTSCDLWVHTECEPDPDPMYHSVDLPIDFELGPTIESAAEDSTALDLTDKQRRRLNDDKIARRLIFSTHYDPRVMSKYECYTCRRVRCFRLLKALVAEDKFLLFREPVTVEIAPTYFEVIKAPMDLRTMENNLKDQQYVHALCADFRDHFELMCLNAVTFNSKERDFSIWREAWRFYNAGLRLLRQIMPSTLIVTGKFSEHMIAAAKRQLPNNSVLANKEEPKKEVEEAPPVVDEETDKKDDVVAVERVVETVVIDGKKIIVPTELGSVPKPYSCLSSVVATLSKAQAHEMSWLDVCMVCCSSGQTQAMVFCVDCGEAFHGFCLHPPLDLEGRSEKIQEYWRCPNCKICEFCGRCTPEDESHLLVCDVCERGYHTFCLKPKLREVPSSGFVCGSCVQCESCALPQESTSWSPSASLCIVCSGEDTIKKRTKRSTDCCPVCSRKWMASEPLIQCDGCELWVHPKCDSITKETLELLADDPTSEYFCPDCRKKQRQHLDIYENAWSLQRNVALIQDKRQEIAEAWQTKLVNEQTTRQWDHWREHCPVYLYIMRLGEDCLKSLAGRRLSFQLSTQATMAQIQLIPLGIRHRASRYLRFKRYARGPRAALRRQNRKKEQFFSWEGVKAKESAIANVVSEAVSAASFLACCAWLYGTKKLTRFTAELLRASGETIPDAVLNHVIDPTAISMAEEVKFLAAEYKKRTKVHKQDTEVKAEPAPETPVVPPTPPPVVEVLPESQAHMTIIKPLHGWELWDHLSHLGTFEDRRMCGFCRGLGDSSVCGRLIFADYDQWVHVNCAFWSNEVYEDAYGTMLMCQKARFRGRTTRCSVCGVTGATVGCHGLRCQLNFHFPCALSQQNFTLEKQAFCHQNDHWMAHLKKRDEKKRKKEEEQEAKRRAKGETIPDEEPLSLEAEVELCMNDLVNTLCTENIDATLEPLRFLMSDPLNDKKTSKTQMAKGTCYRVGTLCVQKLGSIEVGNDAFHTKHAIYPVGFRSTRIFWSSKVLEARCLYECEILTEINPATLTKRPLFKITPCDDLENPLFGHSPKDVVSKLRSRVLALYEFKRVFRTGWNPFLKRNSWFSYGLLGEHFFGLTIPIIGAAIESLPYAPTTALLDSQNPYPYVFCHVLPTPAMFEDAKVDIKRFRAANEHAKHSSGCARTDGYSWHRLKAKPDISKKRKVNVSKQANDDPSNGQLKPSTGMELLPIPMQYRELRRRPFGERLEVRKSKIHGYGLFVKEAIGEGKMIVEYQGQAIRQKVADMREKRYEEMGIGSCYMFRLDKDVIVDATRTGNLARFINHSCDPKANARIINIDGNEKKIIIFAKVPLQPGDEVTYDYKFPIEDEAIPCDCGAPNCIGRMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WMC8</accession>
    <name>A0A6G0WMC8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_013679</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000176">
        <property type="protein sequence ID" value="KAF0728492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WMC8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014601"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="491"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="526"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="561"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0728492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="623" mass="67944" checksum="2FA52F1A083A531F" modified="2020-08-12" version="1">MADQVATPIVGVGGGYVSLWDRRPVQVTNVLFQVCGFILVMELSERLSYYGINQGLKNFMGKKLHWSSVSSNSIKSTWTSVVYMSPLLGAYMADERWGRFKTIAVFGTVYMLGDVLLAIASHPSVLATNGSTSTSEGLFITGLFVFIGIGTGAIKSNVITLGADQFDPRDERQVAQKMTYFSYFYWCVNAGATFSYGYLATLCVKGSGAIPKEYGYFATFTICAGVFILALSIFFLGSPRYIKVPPTNKAMSKLVRVLLGSSSKSSSALFSVLGFVAFICSFIVNLIAVFLKDGSPERKGLTYTAGAFAFLGVFFWAAFGRLYENMSAAKESNGGPFSDQDIEDIKRVVRILPFAAFLVMWNCVYDQTDANFQSIAQQTDLRLGSDRDATQVSGAVLGVFDPISIVILIPVLEQIVYPLYTKWAGKPPSQFGKAAAGLIIGSFSMFYTGGFETIRRNAGNVLLPNATGQLDVILDASSELPMNDVAWGWSIPMYALVGLCECLINVTAYDVFYSEVPAYLKSTSQAINLFMTSMGSNATSIFTLLFQKYIPNDLNDGHLEYMFYAVGAVSVVNTLAFLWAMKNMNFGMSSSPKYVDGSGAEDYGLPKKDSHLADAEKARLSYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WMJ4</accession>
    <name>A0A6G0WMJ4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_013708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000176">
        <property type="protein sequence ID" value="KAF0728524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WMJ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010027"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="380"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="406"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0728524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="448" mass="49560" checksum="9F7979155D5B33DF" modified="2020-08-12" version="1">MQQMRENYRKAMTDFEATSRAREVASKLSADIEHQRAVEAEQQLRRTAAERDTIEITRQRERSSSNARTNDAEARSAAATAENQRYLAEMQLLKAQMAASTEALKAKDAEVQRARAEATALEQARLAAERRAADAESSRSTFPSPPQTFFMQQPPTSPIGSIPTSTENSLPNKAPNLTKLFKIDKFSSKESYQGLGADFNSWLDRFYDEIRMETASNQTTWTEEHKYMALKKSLDDEARGFVLAQEKSWRAVAPPGETYSFSHLVNHLRQAYSTHLDTDQLMAKMRMEKRYAHTWNQHVQYLRHIQKQIGASNRLVLEMFTKYACAEFKTNLVAGVNRANKDDPTELDKAVETLVQLTGTGVNYGKKGRTTASGNTNMASGSSPNNGSRSGNKTSNSRNSGEATDAAAGVAAGAAVNGHVTFADKTATSRHSAHSSSRPKAKPAEQPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WN57</accession>
    <name>A0A6G0WN57_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_013506</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000173">
        <property type="protein sequence ID" value="KAF0728763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WN57"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006967"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0728763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="161" mass="18453" checksum="60B09AC231AD6831" modified="2020-08-12" version="1">MNTEAWSSLVAVESRTLFFGPSVKHYTWTLKGNVLTMSTSRQGIQRTVHVKQGFAWPNKEFGFQVETDKGEWIRAVAISKRDWAMWIHALHAKHPNPKEESPLSKKVNFHGKVRIRSIPKLSQDEISKLYYSDKEIDKMAREVSSKDGLLVAKRRLAAFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WPK1</accession>
    <name>A0A6G0WPK1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_013047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000166">
        <property type="protein sequence ID" value="KAF0729301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WPK1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019899"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF22">
        <property type="entry name" value="TRANSPOSON TY3-I GAG POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13975">
        <property type="entry name" value="gag-asp_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0729301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="543" mass="60003" checksum="A2F7C95BC0DD5681" modified="2020-08-12" version="1">MDDLTDVAEHADGEDSGSTSFEDENLPSDCVTYLSDIPTVRSGVRQSENPKCSDEFWDELPLDYPHSTPTASTQARLKSQQLRSLHRKSAKIDPTYCSDLLEGNLPSVRLLCRLTRLCHTRSRSDTDPFNQAYVNNMKATTLIDTGATSSFVSATFWHKLGCPTLSHPRSSFVSADNSQLEMLGRIKLTINLAGRKVLFPFWVMSTALTDCIVGIDLLRQMGAIINLNDNTLSIDGCDELISLSPLSPAQQETHPTGPVTVATTTQIPPRSFQWITCSAGSDLPTLTTILVEPTKSALLHVAAALYRTNQSRTVLLEVANPSDSPIHRPTHAILGIWMALPNDHLESTTDSNDSRVQVDNDHSSQTTDEPRRVLTQIGGPGVVCPVQSETTPTKELPIDWTESSLSIDQRELLRKTLMKFSDIFVDSSKAPGRTHLIEFSIDTGNNPPIRSVPYRTSKAEGDIMEAELNQYLDLGLIRPSKSPWSSPVLMIRKPDGSIRFCIDYRKLNSVTVKDSYPMPRIDDLLDVLGRAKLFSTMDIASGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WR82</accession>
    <name>A0A6G0WR82_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_012550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000159">
        <property type="protein sequence ID" value="KAF0729911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WR82"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001666"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0729911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="193" mass="21768" checksum="306BFE730DFB3177" modified="2020-08-12" version="1">MVPDSLDRELMAELFDLTSLSNVVYLDSDTETEQLVSQNNSCSIPAGNDYLFDSFYLNTVLNAAFAGYGGWNASDSWIIVDCSFENRLIEDTTMIKFFLLDKAQTKITTFVLQTMTVSRPRMHEKLSSGLATWTTTTLKSLKVTKEGVITWTEAAEYLSPLDLAFRSRKMTSLQFSWRVSSLKEQHGLADSIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WRN0</accession>
    <name>A0A6G0WRN0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA replication licensing factor MCM5</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ae201684_012416</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="VJMJ01000156">
        <property type="protein sequence ID" value="KAF0730121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WRN0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012236"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17756">
        <property type="entry name" value="MCM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000929">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008048">
        <property type="entry name" value="MCM5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054125">
        <property type="entry name" value="MCM5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF42">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21933">
        <property type="entry name" value="MCM5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01661">
        <property type="entry name" value="MCMPROTEIN5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="14">
        <location>
            <begin position="321"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF0730121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="719" mass="78995" checksum="36C86D95D4C4DB3C" modified="2020-08-12" version="1">MDWDRGAVSSLAGGGQPGAPSSSNGGTATSYDLTRRCVSFLRGFREENTFVYRAQLTSHVRRSHLVLDVELRDLTSFDPELGDMFLSKPAQMLPLLESAAAQVAKLSPNQPIQIVLKSATMESLRLRDIHATQVNRLVKVPGIIISTSKVRAKCMSITVQCKNCGHLKTLPCPSAFQGVAVPRNCDRRAQSDADGGMGVLNQDCPKDSYIIVPDKCTYVDQQTLKLQESPEVVPTGEMPRHLLLSADRYLVDRAPPGTRVSVLGISSVFNAKKQVGAVAIRTPYLRVVGIEIDEEGAGRARVVFTPREEEAFAEMARDPNLYEKLSSSIAPSIYGDYTVNIKKAIACLLIGGSRKRLPDGMILRGDINVLLLGDPSTAKSQFLKFTEKVAPVGVYTSGKGSSAAGLTASVIKDSKGEFFLEGGAMVLADGGVVCIDEFDKMRESDRVAIHEAMEQQTISIAKAGITTILNSRASVLAAANPVFGRYDDMRTASDNIDLMSTILSRFDLIFIVRDIQDEARDRSMAAHVVRVHTNQFNQSLQDAHGEIEPALMKRYITYCRQRIAPRLSMDATQALQDFYVQVRDNVRQDEKERAIPITVRQLEALVRISESLAKMHLKIEVSAENVEEAIRLFKVSTMNAAQDGGTQGLFGSFHEKAAVVEEAILKMVHIGVRMETTALYSKLESQGHNPNAIQRAIRAMVQKGSLKQMGQYKFVVRMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WRQ3</accession>
    <name>A0A6G0WRQ3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_012411</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000156">
        <property type="protein sequence ID" value="KAF0730116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WRQ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012232"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0730116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="222" mass="25109" checksum="177942DBAB866FB6" modified="2020-08-12" version="1">MQRVRVVALRWSRGFATSEGGKKGKNAIFEKAMANAPLKPTGVTEAEEISKLVKAEEASPSAPLFFSDEELDAEYGKFKSVMEDDDDEESDYAPVQGRVENEMIMADKTWPLTSGTDLFMDLIQIPKDGHLEDNERELVLKEAFRRMGHTSVWDIKLPTMSVEIPKDDPDYEALSIMKQSLMNNGRIKMDDKNEIMAMIFDEVTRLRADKTDLIPGLDLDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WRQ4</accession>
    <name>A0A6G0WRQ4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sorting nexin/Vps5-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_012393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000156">
        <property type="protein sequence ID" value="KAF0730098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WRQ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003953"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035869">
        <property type="term" value="C:ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009602">
        <property type="entry name" value="CBAR/FAM92"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21223">
        <property type="entry name" value="CBY1-INTERACTING BAR DOMAIN-CONTAINING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21223:SF2">
        <property type="entry name" value="CBY1-INTERACTING BAR DOMAIN-CONTAINING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="108"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0730098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="26520" checksum="0E81F1F9A212B882" modified="2020-08-12" version="1">MREDLDERTAYLWNAVQVLERNVKIMEDSIRQTIVFREQRDAHAAKVARALDDCASHEGVPSLQRAFASYADATRTLSVDTHELLVVRPEQLAMVELAQIQDWAIVPMKRLLEDREKAMKAVLKLQRDVEDKLQTNKEREKRMRLLQEQRRRAENVNSLVDYHMKRFEFFRVTKLKKVMNELSRAQLFYHCRGLECFTPPCKAIPLVDPKAASEDIRSDMMQHARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WS26</accession>
    <name>A0A6G0WS26_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3752 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_012230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000155">
        <property type="protein sequence ID" value="KAF0730227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WS26"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002420"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022226">
        <property type="entry name" value="DUF3752"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046331">
        <property type="entry name" value="GPAM1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46370">
        <property type="entry name" value="GPALPP MOTIFS-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46370:SF1">
        <property type="entry name" value="GPALPP MOTIFS-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12572">
        <property type="entry name" value="DUF3752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3752" evidence="2">
        <location>
            <begin position="248"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0730227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="377" mass="42233" checksum="CE7B941E8C1CE805" modified="2020-08-12" version="1">MSKHGKTDKKHDKHEKHEKKRKHKKDDKKEKSSKKHKSSVSSEEVERAMDLKSALQHVESMIKEFPDLANDLRGIFQMVDAGEVVVIGGIENQEMKNRLASMFPLMGLVESGPNQSFSKHKVAKHISLIEKFGGALSPPPAQPARAPTPKPRAQPIGPQMPPRAPPVEQNDDDVAVGPALPGMRGYREASADVEERMRRQAEAEEALQWKKLRGEADDTSKPAVVQREEWMLSLPNDESIQAALGGAPRKFRARDKDERDDTWFAAPADREQAMREKAQMEMLGYVPGKVQAPNERPRAIAVEETGPTVQRRQGKSLLEAHQEARKKDSDAGPVPWDRERDMSSRRQMTGDAAAKLIQQANEMSSRFAAPKVSRQFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WSK7</accession>
    <name>A0A6G0WSK7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_012113</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000154">
        <property type="protein sequence ID" value="KAF0730411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WSK7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021000"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911">
        <property type="entry name" value="ACYL-MALONYL CONDENSING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911:SF137">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER G2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="19"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0730411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="312" mass="34114" checksum="8C125A6888A3FEBF" modified="2020-08-12" version="1">MRKDTLAQLNSAMTAQERLGVTYMFLSAVIFGLTSIYYKQLKDVPSVQIVLHRIVWSLFFLLALVFWSGLYANFCATARCVVVSLCVGVMAGYIIETSLGFFINPIFTVLLAVIVLKEPLRRWQKLAVFCVFAAVLVVVIVYGKFPWLGISLALVLAFYGLIKKLVPLSPLEGVVLEMMYLFIPSLVALIALEVHGTGAFGHVGTTQNILTAGAAPLISFSLLGLLQYLSPIINFFLGIFAYHEPFSTAKLIGFILVWIALTIFAIDGVMATRVKPDDAADGSTESSPVKEEDVTALPATPTADYKDVDDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WSM9</accession>
    <name>A0A6G0WSM9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tubby C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_012134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000154">
        <property type="protein sequence ID" value="KAF0730434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WSM9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015955"/>
    <dbReference type="OrthoDB" id="62175at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.200">
        <property type="entry name" value="LURP1-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007612">
        <property type="entry name" value="LOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038595">
        <property type="entry name" value="LOR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04525">
        <property type="entry name" value="LOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="Tubby C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0730434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="18584" checksum="23CB38B3888AEB03" modified="2020-08-12" version="1">MGNHLSSTEFETTELVAPKAPCVAIDEHFLSHCPLRLDMGSGPIVRDMSSGASMFRVDGDCLRDLDGHTFAIVKKGIASKTIVDAGDHELFVIKTGGSVARCSVQDPISGARHAYSVVGTLSSSKALILCDGEPVAKFRHNGSFHFGPCFHLDIAPGVDVALVVVLCLALFPSNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WTV2</accession>
    <name>A0A6G0WTV2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_011702</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000148">
        <property type="protein sequence ID" value="KAF0730939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WTV2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009292"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056524">
        <property type="entry name" value="KIF6/9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF36">
        <property type="entry name" value="KINESIN HEAVY CHAIN ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23735">
        <property type="entry name" value="KIF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 6 7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="10">
        <location>
            <begin position="5"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="449"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="595"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="676"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="630"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="499"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="521"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="681"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="93"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0730939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="734" mass="83964" checksum="C215EA6A42B344B5" modified="2020-08-12" version="1">MGKNGVKVIIRARPTAVFAQNQIHIDQDENTIEINLADSKVDMVPSNRKDSWKFKFHQVLQNAGQDKVYEAIARDIVHGAVVDGINGTIMAYGQTGAGKTFTMIGDTRNYQHRGIAPRAIAQVFQEIESRIEIEFTVHVSYMEIYNDRIFDLLAPDDMDMNDFVVVEDAKGTYVRGLTQIETSTEKDALDQLFNGEMRRTVAEHQLNKRSNRSHCIFTFHISQKSRTGGNEHVVHSKLHLVDLAGSERLKKTMNDEDGTAHKTTIKKESMYINQSLTFLEQCIVALGSREQRHIPYRQTKLTNVLKDSLGGNCNTLMFACVWGESKHLEETISTLKLAQRMMRVQNEAMSIVETDPNVLIKNYEKQIKELKQELTMHDALVERTGVIYDEHTPEQKFELMRLVRAYVDSPTDDETMLQLTSIRHIKELFRQFKLLLKNAESASPQIAARSMTSHVPRENGNLDSSLDNEDKLVGDPDDNSGFVLGIAPSGAIPASLDVANKKDGNPRADDNIRDASPVDQADEKSNNEAKGEPQEVDKDEAYKFFITSGTGKKIHISLQDEKQSLKASKDKVRDITHQLNTTKILIDELRQQIEEKRTSRKKTSVSKESKDSKDDDEVVDEEEFILMRKEREAKRDYRVMYDDLKEAKNEYDFIQRNIELLRMRLVQEFEEWYQDGGSQAKADEGDRDKLDEGEKFDQMEVERIRAQDPDSLAFFQAQKKMRQMGSSNQRKAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WVT9</accession>
    <name>A0A6G0WVT9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase M20 dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_011214</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000141">
        <property type="protein sequence ID" value="KAF0731594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WVT9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012466"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050072">
        <property type="entry name" value="Peptidase_M20A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43808">
        <property type="entry name" value="ACETYLORNITHINE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43808:SF3">
        <property type="entry name" value="ACETYLORNITHINE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="3">
        <location>
            <begin position="202"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0731594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="437" mass="47754" checksum="69C24FFB191EE681" modified="2020-08-12" version="1">MAVSLLDVTLNEEAYISLLGKLISVSEKVQNAPGLGLIPQEDLVSDFVLEELKPYLKQNGGAIEAQRIGFKEGRGHLILKYAGKTKPDETINIVGSHMDVVPANPESWDRDPFSLTVEGDKLYGRGTTDCLGHVALVTQLFIELAKNKIETQKTVSAVLIASEENGEIAGVGVEVLMETGKIDFLKNGPVVWVDCSDSQPCIGTAGALTWSLKATGKLFHSGLPHLGMNALELAMDALQVIQKRFYEDFPSHKDEARYNFATGSTMKPTKIESSTNGINQIPPWTTISGDVRLSPFYEMQDLRAKLKEYVDDLNANITSLESRGPHSKYTLPKENLTSKLELTLADSALEGIACSLDSVGFKSFDEATKHVKGVSEPYAIMGSLPLVRDLQRAGLDLTLAGFGKSSVYHGDNEYCLLSDMKDGFRILNRFIHNVDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WXF8</accession>
    <name>A0A6G0WXF8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_010542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000135">
        <property type="protein sequence ID" value="KAF0732250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WXF8"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="1">
        <location>
            <begin position="66"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0732250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="99" mass="10889" checksum="F5F08B068B4663DB" modified="2020-08-12" version="1">MDNPDLMQVLDITIKHVALPTNNVPPSRQGVSPSSVRGPAYAFETDPLSHNMQRMALGVDINECCLPPGWSARYSPSKQRVCFIHEESGTIQYTHPAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X006</accession>
    <name>A0A6G0X006_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_009936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000126">
        <property type="protein sequence ID" value="KAF0733114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X006"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004410"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0733114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="456" mass="51420" checksum="EFB49E0B99456E53" modified="2020-08-12" version="1">MAHSGWKSQGLAPQFGRFIPPSMDLHTLESTFRKLDQKMEKILDDQDAKFRKLEAALDNGRHRIGVLEKQVECLADVTVKALKEHVLPHAINVVRRPSSFTDSLLTTTSTVLFVWKDGTTRRAPEAWTFPTTDCRKLWQLWFHGDDIARIGPFRLLAKCDLKDFESKRQLSVARVVVRVFVNLAVSTALVTSEAALIDLPLDTSLELFDQVLNQLLHNDPSGPHQDNSEESGGLLQVSNVLSLPYSRIYDAFPDEVKKQYHSEESTPSFEWRDGSKHCVPEDWTFPTEACKEMWLRWHLGEPSLGIVPFRRLRESHLKLKACQNQLAMNTVVFKKLSEIAVEHSFAESFEDLEEMLPSDLSVVFDNAISLLLPNSDKEARRRAKLQTSSIAAVFKAMTQPVDVVKHPGPIKRKTPAASSQFTEPVKKLSSRPSAYQETSLLPPSARSVGRLAGRDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X091</accession>
    <name>A0A6G0X091_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">VASt domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_010007</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000126">
        <property type="protein sequence ID" value="KAF0733190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X091"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012811"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031968">
        <property type="entry name" value="VASt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47666">
        <property type="entry name" value="PROTEIN VASCULAR ASSOCIATED DEATH 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47666:SF1">
        <property type="entry name" value="PROTEIN VASCULAR ASSOCIATED DEATH 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16016">
        <property type="entry name" value="VASt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51778">
        <property type="entry name" value="VAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="VASt" evidence="7">
        <location>
            <begin position="185"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="152"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0733190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="457" mass="51025" checksum="F0A8D52625B9C3F4" modified="2020-08-12" version="1">MASAAPSPTSSSGRSTEDEVVVDAGGVEMAPVHDEVRDDIICAIFNLPKTTVFYQDFSCAYVSTIVYHGRMYPAGDQVCFYSNLFGKETKILIPYKTITDVSKTSNMFSHGLRIHTRTKEYSFTSFWGNNRDHCASIIHALRVKAVGDVPSPASSIASSPKSPTPVSLPPPRQDVPPTANVDEHPYLDMVEDSFEISVDRFVELFMGDEAIYGLGEANRRRGATDIQCALWVEQPDEEGVWTRTASFTQPVDAPIGPKSTRIQVSQRRYRVDDKTYHIDTTTHILDIPYGDCFKVDDRFVLTAITESSCDLLIQLRVIFNKSTLWRGIIESRAKSDCKQKSLDWIQLAKQALTPEGLPPYPLNAKGVRLARKPKAIKTKEDHKKQPTDAPPKKRVLVQLHVRPLASIVIPWIVIVLLGLYIYKIHSDLAAIHTTLREVQENISTLQSSIGRQCAPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X196</accession>
    <name>A0A6G0X196_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_009558</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CDC50/LEM3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000121">
        <property type="protein sequence ID" value="KAF0733626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X196"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009864"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005045">
        <property type="entry name" value="CDC50/LEM3_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926:SF0">
        <property type="entry name" value="CDC50, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03381">
        <property type="entry name" value="CDC50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015840">
        <property type="entry name" value="DUF284_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0733626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="406" mass="44414" checksum="A51C0AEA9996EA03" modified="2020-08-12" version="1">MASPTPTSAVADINKRRELKNRPDDSKFTQQTLRVWKPILTLQWAIGVLSLGAIVCLTLGGLVLQRSSNMSLYRVLYDAGSKSNGVAPTAVQLGGTVAYLDKCHLGSPQDANSFSGSKTCFVTVTLDRDIVGDTIVFYELAPFYQTHRRYMTSQVLQQYMGGWSPGDSTSDCDPVLASPSTQLCNGTTCFGTNKSRQHYPCGLVANTMFNDIFWLHNGTLPSGKVLGPADLKIAGIARTFTNYNFKNPQTPLDLDTFLPIWHNPNYSRIIPPPGSDILPQITSDYTNSTAWVTTPPGTGVENEYFRVWVNLAAGNVLRKPYGRIAVPNLPAGTQLTFAVQSNFYTEGSKAIVVGEIGWFGSENIAMGVLFIISGSFCLIAALVFTYKAIKNPRRLGDVTSLKWKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X1D8</accession>
    <name>A0A6G0X1D8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Temptin Cys/Cys disulfide domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_009545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000121">
        <property type="protein sequence ID" value="KAF0733612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X1D8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019571"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057626">
        <property type="entry name" value="S-S_Temptin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055313">
        <property type="entry name" value="Temptin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34737">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34737:SF2">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24784">
        <property type="entry name" value="Temptin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Temptin Cys/Cys disulfide" evidence="1">
        <location>
            <begin position="3"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0733612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="122" mass="13361" checksum="DBCBF69C994B1EAA" modified="2020-08-12" version="1">MNHRSTWSEELCNLDSDGDGATNGEELGDPCCVWKFGDTPSRSTLLSHPGEPNNFTRAELDKLQCVKAPRDECACMSGNCTNGKCQGCNLVDDEGGYYCVPDVDAAGCYMMQYPYVWCGELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X2H6</accession>
    <name>A0A6G0X2H6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_009266</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000118">
        <property type="protein sequence ID" value="KAF0734098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X2H6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002794"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0734098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="557" mass="60125" checksum="9D5FFB88F55188BE" modified="2020-08-12" version="1">MGELGARYKYTANHVTYACPDDDEDKQRGQLSRAHLQKRVRSYLSLTLSSELLGRVRTDISNLQQLKLGSFDLGDRGAWVLGKALASNRTLRLLDMGFNGITEKGIEQVAYALEKNKTLKTLYLSGNCVGVDGAAKLAMALRSNQTLQSLYLSGNGIADEGVKHVADMLHVNTTLKALYLGTNNLGSTGMMYLADALAVNSTLEELMLSQNQIKSTGIQYLVDAFASSSMLQLHTLEIGFNDIDASGVIALADVLRSSPNRLENLYLDNNPVGDAGAAALGHCMAANSTLRVVDLSYAHLSLLGLRDLCNVGLRHSTSLMGLLLDGHDWSSTKYMERPPPNVTSLSKTDALTYAAKCVVTSVQANTALPLIKLTGVNLGFAPGLHMVLPEALELTASQSLCALNERILEHLRTLKPPTEEERVLEESRKVLGKIAQLGFDTDELKALCAYYCADLLVSEPSNKRRRLSVDAEGPTAVAAGVASSHNGPPSAGRVSIYPGVEKRLRAMVSNTTMEDATVKQNVLTVLRQLHYLVKSLHSMENASVLIETLLGSSSSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X2L5</accession>
    <name>A0A6G0X2L5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_009013</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000117">
        <property type="protein sequence ID" value="KAF0734145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X2L5"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0734145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="177" mass="20065" checksum="24FF22054C3AD532" modified="2020-08-12" version="1">MSSKAPTLVPHGSIGVATFESITLWAWRSSHCHRVMPSIMLVPIPGRVQNERLKMNGLVVLSQIHGRVFHDVNWAQLRERRARERFVPAPSVGTCWTYMELKCLNQCETVVQRRDGASETMSFEQDAETPAVIYRFFAERVGGILSSLTFLQYDVSFCRLQVVLSASHPWQEAATTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X2N5</accession>
    <name>A0A6G0X2N5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_009033</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000117">
        <property type="protein sequence ID" value="KAF0734165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013928"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006337">
        <property type="term" value="P:nucleosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045815">
        <property type="term" value="P:transcription initiation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000061">
        <property type="entry name" value="ATPase family, AAA domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045199">
        <property type="entry name" value="ATAD2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23069">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23069:SF0">
        <property type="entry name" value="TAT-BINDING HOMOLOG 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="7">
        <location>
            <begin position="927"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="42"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="172"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="211"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="233"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="262"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="299"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0734165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1364" mass="152294" checksum="EE95C80149BDB99D" modified="2020-08-12" version="1">MRTRRRRDDDEAPVIEINESPNVDILQRLPRERRRTVRYIDSLDAFNHQRQRRHPTTPENSDAQEYLQQRATRSLHRTSLPSSSDENEEEEDGFQEQPSFGDDENDEVDETNESDLPSPQSRRSSGVSIKEENPSELESAGQGNYRYSTRRRSRSSIEPEDETSSRQSIENEEPRQDEDAIEEESRSTRYPRRRSRGSHEPSGANEDEGVSYSQDNNTRYTLRNRSKLAPIDRLYDVDTSDKKKSIAPSSLAYGTRSAAQASERHTRYLLRSKRDAPPSPKNGDGSSKGYSLRNRNAVRRQQSSYSEAPRLSNQLIYDDYGDPRPPKRSKSNSSSAPKYMDLSGSSSSSEGEMQTMKRSKKKYAKSPKAPPPADISPLDIDPSITWDSIGGLKSHIHSLQEMVILPLLYPEFYSKFSLKPPSGVLFYGPPGTGKTLVARALANSTGSQKITFYMRKGADCLSKWVGEAERQLRVLFEQAKKTEPSIIFFDEIDGLAPVRSAKQDQIHASIVSTLLALMDGLDSRGRVIVIGATNRIDAIDPALRRPGRFDRELAFTLPNATDRAAMLAIHTKEWQPPLSLAFRTQLANELVGYCGADIKALCAETALVAFKRTFPQVYDTPAKLEIDVNAIQVLRADFQVAQAKIVPAAARAQSAVATPLPPLLKPLLEAPLTGLVKLIQTTFPGGLFAPPPIVPSSSTPIYELPSSSCAGCLMPLMDDSSPCSQCQVLFHPACLRGTGRCSSCVPSYSYVPPSLVCCLVYGASSAMGQAALTSALLSHMDGFPCIQFDRFSTPAQWMAKWAEVLSHVPCVVYCPHLDQAWVDHPNEIPPLLHHWVQTAQHLPIVLIATASTRDLPSDFADLFPTSHHFQLKPPSRAARHGFWQVVQTWASSPPPIPLPPPKPLRVVAPPPTKAPKPSQVLTDHEQHQLRELRIFLEAVVSYCIRQKSNAPFVAIPDGTIDLSTMRDKVHDGEYTTWEKFMTDIHAMVQDAYAAYPKYSPLRYIAHAAANMQDNVMSFAHRFRKEQGYDLFAQCREIQQAKLAKRPVPAPMPLKRPGQLPPPTIIEVENGNDYNAAAEVEEEEDLETFQTGDHVFVAKRTGPGMNKLGGAGLVQQVYVDDETERVTKYDVKYVLGGFEKEVEARYVRRLTEDTVQESVKMHAQPVLGSTLIAAAAAAPPTANKVFDATIWPHLYQAGWEFVAPHMLWVENPPESTTDLTKDELQSKHTCFESRDDVLAFVKQTPKYARLCFGQRYVEMNIADGLLPKPTPWTPQEEIYYMMLEDKPIEASQPVATPTSEPDFILDEAALKVVVSTLVDATDGWSVDDLRQALVKVNHIVLAHRQDYDRSAMIAELLVHAQQLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X351</accession>
    <name>A0A6G0X351_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_009076</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000117">
        <property type="protein sequence ID" value="KAF0734211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X351"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020297"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0734211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="28551" checksum="68C60A3C217081B2" modified="2020-08-12" version="1">MGLHSFASVPSLTNADALKTIETPYRSRHASLSLCSPRDEDKRFSRRMSTLRLSLDELSSNLHTTVPTDDDEWGWFTDIEASSTSSSDEESDSPTATTSGSQRVIWRMFPPLTDLRFEPPFHSCDFPWLLSLSSTDPQTARLEVREFRIAGHGTYAEFHVMCWIGDAYFNTWKRFSAFKRFVHTELKTNGHRRSLRAWNDVLAHCSWFRSLNVEYLHQKCCYLETFAHTLLMEAESPYLLARFMACGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X367</accession>
    <name>A0A6G0X367_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_009111</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000117">
        <property type="protein sequence ID" value="KAF0734250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X367"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015165"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015166"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015149">
        <property type="term" value="F:hexose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF8">
        <property type="entry name" value="FACILITATED GLUCOSE TRANSPORTER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="26"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0734250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="502" mass="54842" checksum="35E50F88DC5A1F47" modified="2020-08-12" version="1">MSEEGEFTKVEVADKLLKASPILQRSVAVALLGAAQFGWMLSEMGHLPFNNASLCRQADIPEGQCLLYPGHTTAQWTMQSTAWALGGALGALASAFLADTYGRKHTLGVNGLVMILGGLVQMLAPDMETFALGRGVSGIASGVAVNVLNNYLREVAPKQWRMFYMTLFHITMGFTAVVVSALMFAIPKVPTSAWQFKPLFGGPIVIGGLQLATMRFIVESPMWLLHRHRDTEAKQAVSQLYMSGDIDIYFVELAESMRAQTEESEAASSMLGLLVSPRYRVQFVIAVVLGTMQQLAGMSALVVYGPSIFKAIGLADLRLANIFMNYGRTHNMIIAALIGDRFNRRTLLVRLSVVMALAALGFTLCQVYMNDTSKYVVLVMLIFCVTSYTLSVGSLGWLVSTELLPEALAPTSGSFATFGTWMAQLFIGVYFQQISSPTHWGTQAFAIFAVLTLLFAVLAYAYVPETRLTTTDQVTAIFTRDNQDMFDSISTPKTPQTLESTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X3V6</accession>
    <name>A0A6G0X3V6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_008751</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000110">
        <property type="protein sequence ID" value="KAF0734595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X3V6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018607"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000967">
        <property type="entry name" value="ABC multidrug transporter mdr4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="323"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="62"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="425"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0734595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="617" mass="66503" checksum="5D6BE9AA32289D47" modified="2020-08-12" version="1">MAKREDEYKTIATPKDDQVVQVDAAKPSTNLSKGKASDVDDDFSFLAVYRYADAKDKLLLTAGFICSAVNGAGFPLMAILFGDAINAFVVPVNFDTVHEATLSFLLLAVGLFVAGYGSYACFAVSAERQMKKLRSECLKRIMYQDIGWYDQLDVSELASRISGDTVRIKDGMGDKLGEALRFFCQFLSGYIVGFSRGWNLSLVMACFMPLSSVSVAFLMKRLQQSAIHTQKVYAAAGAVAEETIGAMRTVASLNGEARAMAKYAANVAEAETVTIGVSTFVSVAFGWIFCLIWFTYAIGLWYGGWLVSKQHNTVSDPGTVLGAFYGILIGTMAVGQISPNVNAVAIAKGSAKALFKILESKSDIDASDMNGEIPPTCEGNIEARDVHFTYPSRPEDPILRGYSLTIKKGETVAFVGASGSGKSNIEARDVHFTYPSRPEDPILRGYSLTIKKGETVAFVGASGSGKSTLVALLERFYQPTSGAIYLDGRDISTLQLKWLRSQIGLVSQEPVLFATTIFENIAAGGDNISRDQVIAAAKLANAHDFIMGLPDGYDTMCGEKGATLSGGQKQRVAIARALVRQPKILVLDEATSALDNESERVVQDAINNLMAHTDILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X407</accession>
    <name>A0A6G0X407_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_008736</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000109">
        <property type="protein sequence ID" value="KAF0734666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X407"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010109"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40515">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40515:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="277"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="223"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="193"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0734666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="310" mass="35989" checksum="432256394C055371" modified="2020-08-12" version="1">MAQAVPTGSAPGDVFNKDTFLTSLREGTQANEPHTNVVAAPYTPKGMANVREKYAQLHSVVGSLSEKITAVLVRQEKDFMAAYRAHMYNVQKELHDTKEKILRNETLENKSEKIKLLEEERDWYRKEALRLDAFTTNTTKDLKHMKEKLECIEEDRDWLEKQLKASKKQNKLLRAELEIRLANLTSQASDAKQQNDRPKSPDMMREEPSPVNLQLPLAVVEREEHFRRQIRQLKRELQTSKREVNRLREATSKHQSSEMESFFLESIDAVKKDIVRRRSQSREHKTRPLAGLKSDPTPGMTLYSMKSLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X4G6</accession>
    <name>A0A6G0X4G6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">KEN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_008523</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000103">
        <property type="protein sequence ID" value="KAF0734860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X4G6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010404"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.180">
        <property type="entry name" value="KEN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010513">
        <property type="entry name" value="KEN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038357">
        <property type="entry name" value="KEN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126:SF14">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06479">
        <property type="entry name" value="Ribonuc_2-5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51392">
        <property type="entry name" value="KEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="324"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="KEN" evidence="7">
        <location>
            <begin position="698"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0734860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="833" mass="92778" checksum="DC1755E3F4566BC2" modified="2020-08-12" version="1">MGRQKRRHRPSPSSSSKDADAQKEERAWFLVQAASGNLQILEENYLKEHMSAWLSGCQPAVRQVYAQLHGVVDADGNTALLLAASNGHLALVQALHAVAGFDLHTVNAQGDNALHLAAFQGHLAVVAWLEEHGVGICTDCLDDDGDADIGPSWPQEAVVSTYFAFVRAGDVGRLTNFVDNIGWASFQWHITDECLSTSLHVATEAGQLAMVRFLAMDCQLSISATNNHRDTCLHVAAMEGHLDLVQYFAPLLDVTALNAQKWHALDVACAYGHLSVVQWLVENTSLALSPKCLSLAVQGRHVALAEWLLSVSPSSFVQAIDLETGDSLLHTACALRDASMCRVLLDHQADIYCLDREGCSVLQLVVGTNWLEGLELVVTKIPDALAKLDLVFTARHASVARFLWIYKRLPSKHQPRAFFAAKNASRLDIVQACEAVHDASAAEITTTSIPSMTIQEKKQSTRTEPLLSSLKDSCNVVSDVKTKTNFVEQCGKLVMELELEPNIYFGTHADWGAVLIRKLSKAQGNLDRQYSQQLLRMGWTSELPGGRHLVNIVDWEDTNASNSIFLVHEECTQTWRHAYQRPWTSWAHSVVQHGPSAPTCIQEAISAVQYLHHHRRTHGTLSPASFYLDGHQRTKLLCVYVKQGTDDNGNRVEDVMAEDVYALGQCVVYALTGGGLDYLIPSLSIEALDLVDSMTHVDPKMRPSLNTILDHPFFWTVDSKMIYIESLANNSFALDWTRVGVLFTDWQARLPSELNMLQQRRRNYDKRSVMDLVRWIRNWRQHVSEQPPSVWRILSGDENVSSTASKQLAVGTFVCERFPELVLSLWHAFGRIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X667</accession>
    <name>A0A6G0X667_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_008043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000096">
        <property type="protein sequence ID" value="KAF0735475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X667"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017720"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0735475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="281" mass="31448" checksum="4D224651C0F98267" modified="2020-08-12" version="1">MDPRFENSPGIHLRSQQLAAAVLTTAQAAQRVNVLEEQVGTQANLIQLQESRLEAQGRQIDALDTQLRAFLEAQGPKSSPSELATSAGDHHANSNLGSPIDTPPSSPVERIREAIRASAAVNSSETVTPPDNQDDDLFSAPISPVVDDSNDSDYDDEVVIVENPDRSKKYWVYEYKTLAEVQRYRQAMKAGLCDHRYMGHWTNIAPSHERSVSSNMARCKASIKQCPQHRQWAPQPPPGKLFRREFSARPQGVEAREFFFCARQSFKQEFTGSDKKKTRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X670</accession>
    <name>A0A6G0X670_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_008092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000098">
        <property type="protein sequence ID" value="KAF0735402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X670"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013800"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0735402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="323" mass="37410" checksum="EE90B583826B98EA" modified="2020-08-12" version="1">MACQAEFFHVDCGKSANLFSGMYFRRYTNYHCNVLRCFPHCCPHKDKRCGTSISIRLPATLIDPTRLQAFATFQPSSTRQIQQGESLPVTMFASRRSSTNLRGKWLLGRPDSSSRLPCFHFNADKTEGWHYDWKGGASVMQRLEKHHLCVRSSFHFEFSTMQCRYKVVASASSPPFLLGSYRRALFPPGKSTATPILEKPEVHSHAEVNSSSAAMLYDMRRFCQTLTISDFPSDWRQFEQSLFRELQERFKLTINHSELVQFKGKDELFVGDFQGTRKAALRLLRWWMSPPTQYATRNYMKEVWDGRISEVRASRRKKRGVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X8C7</accession>
    <name>A0A6G0X8C7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_007259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X8C7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019393"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0736237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="126" mass="14558" checksum="0DD8F15C370420CD" modified="2020-08-12" version="1">MVPPLRLQCQYAYKACTNIRTMKKDGDIHKLCAFHRDRANNVQKRYASKRRQRIRELKRASHQLAPSSPAPSPPTNEDLPALKMALLDFTLPDDLFEPLWTISDCNTLSVEESEMLSQLFELPWTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X8S2</accession>
    <name>A0A6G0X8S2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_007353</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X8S2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010685"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF73">
        <property type="entry name" value="PROTEIN PDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="2">
        <location>
            <begin position="25"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0736333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="155" mass="17809" checksum="69609720DAFDC96A" modified="2020-08-12" version="1">MPSTAAMSRAFRKSIDEKTLKCRPNMKLLQPVTYADFETELVAWIDDCEEYGVQVTYGAIKEYAAKISAAYPKCAKLRFSQGWICKFLSRHNLRKRGVFVEAASIDENLVSSGRTDTQELTRSYSPQDVYNLDETAYFYCYEAKHTMSKKQIKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XDW0</accession>
    <name>A0A6G0XDW0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_005779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000076">
        <property type="protein sequence ID" value="KAF0738341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XDW0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005895"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0738341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="171" mass="19588" checksum="82730691E02D9EDD" modified="2020-08-12" version="1">MALSNNDNTDRLHQVVTAANQQLGHALQAFHTHLDDYKTEVQARLRETYHQQDAFGHTLNEHAQLIRQLRHQIARKDREIRQLQEHHTELAQGVMRLSELLAQHMKRYPLDHRNANIDMRGHMGAPCLGIAPGDLPNAPSCSHYKDECPFGYSYHIDGHGPRIDFPALPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XES2</accession>
    <name>A0A6G0XES2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Myb/SANT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_005622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000072">
        <property type="protein sequence ID" value="KAF0738572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XES2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003841"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024752">
        <property type="entry name" value="Myb/SANT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46929">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46929:SF3">
        <property type="entry name" value="MYB_SANT-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12776">
        <property type="entry name" value="Myb_DNA-bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0738572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="102" mass="11262" checksum="2966E2BEAB0A4153" modified="2020-08-12" version="1">MATKASWTEERIAILLDCSCRELARGKGTDASGLKMDGWTRLLRVFNARADMRYTKTQVQGRLSGLKAEYSRVHALRTNSGFGWDATVGLPTAPEGSGHRTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XEZ8</accession>
    <name>A0A6G0XEZ8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_005416</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000070">
        <property type="protein sequence ID" value="KAF0738804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017567"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033053">
        <property type="entry name" value="Hir3/CABIN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15502">
        <property type="entry name" value="CALCINEURIN-BINDING PROTEIN CABIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15502:SF7">
        <property type="entry name" value="CALCINEURIN-BINDING PROTEIN CABIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0738804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1700" mass="195717" checksum="53A2ABDD68B0E036" modified="2020-08-12" version="1">MTSSYERALHSHSTPEVAISMYSDILNFIASLEHIPSSTTRKVMYLSLKNLAQLEARFGPPLLEDALQHFTEALDVDGTDCIVWYEAGCISYRLQKWSLSRMLLEKAFNIDSTFWPTVHKLMNTLYIIGDEHECLRLVQHILTHDSSHRVATALQYLITNEIKSNVALPDCEEAVSDLVKCRLATQKPSPQVNPSKVVYELTDPSWEALGCLLLEIYDSVQNGVTNDAFQVPAFHVPVHIQLNSVIQESKNNHTKLKESQDDKTCDSIHVTNVSEEHDVSPPQASLAETTVIQLNQHETDVVPLEASLDESKPSSPSSNSRRTSHRTLKRIQDEQQAALRFAIEKDVSYRLMAFLNVEHEETPSSLFDSPTIVKISDNRKYLSIIRDGNENKLVLLGDMHESLHQNQSEEEPLNYISRKSVFNVSSFLTSFASGDASNKGIEDVMINFVELCAENYYLKLDEGLLDVILWMNKCIHEELVFNLPLTALPKKLSPKARLYILEIEVDQLVSHFDPLCHSHFDHTASLHHKQCLLDQIKMENDVDALLTRILWLQVQLDERLRHFERTNEILDELEKRLSGDIRLANVQAFPALTHESITAKKRQLSFASLATTARNLFQMEEKEKEIVDLLLPHYDPDLGRAGHIEDLVKDFRICLIHSNESWPSDGDASKLRTDAPLLKILLKCLCRRQSFDKCFQVLVLCLFYALEPLKEESIPDRTTVQCVNYIIAQLYIVVEKPLQRPEPYTELLDFCCFACRDSVLKHYHSSKLLLRMTRLVSPLHVVRFVGKILQDSYSIRWNLKPNQETMSTILTALEQINRRFSLSMSSSERLIDAGLAKSLSAPIAHLLKHQIEAGKYNTMSRHLLYASCSAFALVWNDIHKGKYVDCADLVRLLHEMMTAGDGLQGQGVCALSYEGYNFLEIAKYMLLQSDEDVECELAQCYFCLYGYGLLSSCQNHHGDEAPKRTKDEDHIMELFDFCQKVESKLVRKESAVLFENVLDLPDTKSILQSLVPSSDFQSTLSKYMNPIASNEVHKLSPLSWKNVEAVESNSMGELWFELATNFILPKVKRRGRDYTQLLDYESQCFKYVSYLRNDIFLHPGRAESYHLMASCLKSLRTLVVDHWIVAWLNYKYPQSTIPIDLSSHGMITFEEVTANSFFGRFIAWIEDVQKAGDDETSQQEVIYKSREMSLFYSRYVSVLGELTFRCYDMAAALDLDLAGECYEDAGYLAWNMISEKLQNGSHLCLLAKKYFELGLQNIDGDDAASFRLNYMLGKTVKKHQKTYSGSPHAWQSILEYFHRAETHRQNAELESLPHAFYHLHACRLKLLLGSVDKTGAKQSYLDLTPSPEVLQLVNLFFYKKKSNKSSETSAADLEISREAITIFIQREDTRWIARQHLLWNCLDALENIPQEDRYFHPAYYMYAWGLKVGRVLMDNSSEKWHERFSISTAIKAMKPLFDRKRHQVVAIWLSESETHKLEELHQRQSKYDRLRLKYFSFYLDLLTMAGDSQRVSDLTSWVITSKEEHWVIDAMLLQALGTSSYLARGKLLDLYLKCLFPGQEESNFQQRIYTHLNRTYSVYMEYNEAWHRVRTSNEQSMGNCLWEVAMSYALYIVIHDQHVEWCDQAVAHVEKQLINYSQSVATGHENLLFELYQELKMEEQPYWPTLVDEALNFCSLKWPDKTKPKGKPPVPRSKLRFLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XF50</accession>
    <name>A0A6G0XF50_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_005387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000070">
        <property type="protein sequence ID" value="KAF0738775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XF50"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017540"/>
    <dbReference type="OrthoDB" id="63889at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0738775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="166" mass="19088" checksum="9AD55F7F710D69F4" modified="2020-08-12" version="1">MLRTNSPQWTGPIGRRSQGEGLFSVASMEKKDPGLDVTDDDRQAKAKRLFIPQPRRVTSPELIFRGSSLDRCEKEELCSVHEDVLMEGLDMNDEGDKWHFRSIQRPDLNLQSPPRRTENPLIMDERFHDYAMSAPVAMSFQPPPVVHRPVVRPKAEYPSTGKNFKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XFH6</accession>
    <name>A0A6G0XFH6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">rRNA-processing protein EBP2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_005187</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EBP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000067">
        <property type="protein sequence ID" value="KAF0738998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XFH6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000500"/>
    <dbReference type="OrthoDB" id="443772at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008610">
        <property type="entry name" value="Ebp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028">
        <property type="entry name" value="RRNA PROCESSING PROTEIN EBNA1-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028:SF0">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EBP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05890">
        <property type="entry name" value="Ebp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="33"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="207"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="208"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="246"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="317"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0738998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="38974" checksum="26280C22C91F0237" modified="2020-08-12" version="1">MGNKRQKKGDQLAVVGRSVSALVNAEDATEAEILNTPVLSARADDNNDGDDDEDDEDEEDEEAEIERRLVEEMQAEKAKTQVNAIYNKEAMLALANELDLSTKFKWVETLDTSKFPLELENAHDDLKREVAFYNQTLASVKHAKDRLLKEKIPYKRPDDYFAEMLKSDAHMARVKDKLIFEQKKINAVEERKKSQAHKKVAKELQSQKAKERLKEKNDTLEAVKQWKKRKNTNNSSAGGKDDDENFEKVLESTNKRKRDGGDDGKNKKPRNFKREAANKKFGSGGKTKLTQKRNDRKSTNDFSSFSRSRNNEGVGKRGNKKQAGKRPGKAARSKSMQKRGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XFU4</accession>
    <name>A0A6G0XFU4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SGNH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_005086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000066">
        <property type="protein sequence ID" value="KAF0739159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XFU4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015330"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043968">
        <property type="entry name" value="SGNH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19040">
        <property type="entry name" value="SGNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH" evidence="1">
        <location>
            <begin position="7"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0739159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="182" mass="20669" checksum="41683A8A0650311A" modified="2020-08-12" version="1">MIKRVRPKVVLHSMNWPQFLQPGGKDSDEIVGGPQCCRSSYRDNCDYQRPKDIPALIKQLQADLTELTSLGIKVFVATLNPECKQFEPNHMLSGDDVGDIRPVYKSKFRQEHKELIDLVETAVAAANATLIDYADNYCWEDVCQVVDHYGRPIFKDSDHLTSTFVYRYLSVVDQVIDAAMAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XG13</accession>
    <name>A0A6G0XG13_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_005097</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000066">
        <property type="protein sequence ID" value="KAF0739171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XG13"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015321"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0739171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="356" mass="41969" checksum="878E0D2060CE4615" modified="2020-08-12" version="1">MREAEMATELDIEMLEEVDKTLKKQEKTRYFTKMSQIYRRERKQEREYLIAKSKELQGVLLAMKHRRLDSPSALPWKIVADVLDEEKKHATCRRKTLKAQVDLYECVVREMAKWVMRNTHPHPSLNSRVQTWRDHSLLANPISRRLGKEWILKQMHHNADRIFQEYGCPSNGDNFISFDVVIPEKEDARYVWVAQMDCPFSVDHVEATYCRNLCPILNLNLQYPYPDNTVAEEDGSILLHRMTAATGEVMDLLTTSFREGNRLLVVAQEILTDEILDERNSVRNKSYWMEVFQLPSGQWKRRSVWIVSQQRGYPLAHEARTWGFELQDNVEESFRRGMKAAWARLWPNYHSVVAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XGD4</accession>
    <name>A0A6G0XGD4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_004933</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000064">
        <property type="protein sequence ID" value="KAF0739364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XGD4"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0739364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="127" mass="13996" checksum="BF3765BB0B8827A5" modified="2020-08-12" version="1">MPSEPSMSRCPLDAFGGSKSCEFLNFTTSSSDAGRHAKGMFRRLQGLEVSWLDDGFVERCSTAGRLINHGKMGLDAAKRSDRTFHGENDLFHVVVAKGSSRSQPRRTARWGSFRCHSSSSPSLAWNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XGG8</accession>
    <name>A0A6G0XGG8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_005053</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000065">
        <property type="protein sequence ID" value="KAF0739276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XGG8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017336"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005216">
        <property type="term" value="F:monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006816">
        <property type="term" value="P:calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015925">
        <property type="entry name" value="Ryanodine_IP3_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13715:SF99">
        <property type="entry name" value="INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13715">
        <property type="entry name" value="RYANODINE RECEPTOR AND IP3 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="317"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="6">
        <location>
            <begin position="244"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0739276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="555" mass="64451" checksum="906EEE79498AE9D3" modified="2020-08-12" version="1">MLKYLRAKKRRLLLELDYKSTERLKQFTQAATSFNEEMQHIENLSNFFLYNIVRPYIPHFKNTSFLLAIFMNLIMLVSIRHRDDDNIAYFYYPPTLQDPMTIFGGIQIFLSMCVLVFMVVVSGPLVFRARLNAMIKNSMDTYARKRDFTKQDAESENKINSIEDIKNAIQLENMTNRAKDGAQWARKTIVQLARDSVHFFRSYLPLFRMIGLLYMIQFTLLQAFPDLPVWVPSVVLLLPFLRNTREYLDKSPTWVGLVYTFVYDVAFDKFTSFYTVYLGTAFCATLFHPIFYGYHLLDLVIMSPSLQNVVRAVTKPGRALVLTCLLGLCVMYFYSMLLFFFNQAAATDDEHHIQYCSTLLDCFLTVTHRGLINGGGIGDYLTTSLNHPPPIHDRTAYWLRILYDLSFFVFVIVLLLNIIFGITIDTFSDLRLETNEREDLMKNQCFVCGLTRDVFDNHYMQQGISNGFQKHMAEEHNMWNYLYFIVHLQSRDLTECTGPEAYVKSLLDKDDVSWFPQSMAKCLAKSSEQSTEQDLAEIKGQLKLLAAQMETIALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XHA4</accession>
    <name>A0A6G0XHA4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_004812</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000063">
        <property type="protein sequence ID" value="KAF0739638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XHA4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009773"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="48"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0739638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="154" mass="17670" checksum="707FB449F470FA09" modified="2020-08-12" version="1">MNSTKRPPAKLVYKPKSEQPLVTPKEASNMNRSTSGIAGVLDSLKGKIDDLDAEIKADRKGKKDYEDELFKLNTRKQDITAKLNECQRWIDLFASKIQPLENSYKATTGEMSNEYEEAKIKHANGLQVLIDNFNYHPEFKRYNDDFTAVPFRPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XI95</accession>
    <name>A0A6G0XI95_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_004512</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC43A transporter (TC 2.A.1.44) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000056">
        <property type="protein sequence ID" value="KAF0739929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XI95"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011272"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052599">
        <property type="entry name" value="SLC43A_AATransporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772">
        <property type="entry name" value="PROTEIN FMP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772:SF2">
        <property type="entry name" value="PROTEIN FMP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026233662" description="Major facilitator superfamily (MFS) profile domain-containing protein" evidence="9">
        <location>
            <begin position="25"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="365"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0739929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="449" mass="49469" checksum="3B1B2B52B1346CE7" modified="2020-08-12" version="1">MKVSRVSVFAISWMITFLTSGGLSSGFGPVYSRLVEEKQWSDLCPGANATSAVCSAQEVQLQSVYTTATLMTALGQTLFGVLLDIIGPRYTTIVSFLFSIAGNLFMAYGNSHNGTDSLIVAGYALITFGGMGVLVSTIQLSYLFPEPSVYMSLLVSAFSCSGYIYIFLELDISRQAFFVGYSVLVVLCMLIVFLVFPVRHVTEECMTTTIPGFSVEKPQATTTLMSNIWAGLKEQTKTRGDLWVVTGIGSFLFLQIVYTGGAIPSILTSLTHGDAKLNDLYVNYLYPFVSGSWFLIAPVAGYLLQHHGFKKTSYITLWIFVAFCATLMLPNLAIQNLSFVLLSLANGFLNCLQYAYILTCFPSELYGVLTALVTLIATVFSLLNYAFVSLTQYAFDGNNNYCLGFLVAVTILMLSLVKYLREESECTELKIKHLDEVDFLHQESPRTVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XIC0</accession>
    <name>A0A6G0XIC0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cysteine--tRNA ligase</fullName>
            <ecNumber evidence="4">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Cysteinyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Ae201684_004613</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="4"/>
    <dbReference type="EMBL" id="VJMJ01000060">
        <property type="protein sequence ID" value="KAF0739839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XIC0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010304"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1910">
        <property type="entry name" value="Cysteine-tRNA ligase, C-terminal anti-codon recognition domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015273">
        <property type="entry name" value="Cys-tRNA-synt_Ia_DALR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890:SF3">
        <property type="entry name" value="CYSTEINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="CYSTEINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09190">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00840">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Cysteinyl-tRNA synthetase class Ia DALR" evidence="15">
        <location>
            <begin position="435"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="592"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF0739839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="672" mass="76449" checksum="FCDF3C6D6E2BF0F4" modified="2020-08-12" version="1">MAAAKKGQPTWYMPQPMNSLIEYWERHYPLKLYNSMTRSKTTFVPMQNKRILWYMCGPTVYDITHLGHGRTYTCFDYVRRILEDYFGYEVELVMNITDIDDKIIVRAAENGWNEAHPGQSLPADKDAAAKTVLQWASEQSAESNMKRTADLSKYFEKTFMDDMAALNIKPPTVLTRVSEYVPEIVEFVEGIIKNGYAYESNGSVYFDTVAFGKSKGKNYGKLVPENVGQSELLAEGEGSLSVGASDKRNANDFALWKKSKQGEPFWSSPWGEGRPGWHIECSAMASDALKHLEGGRIDIHTGGVDLRFPHHDNEIAQSEAYFDFEQWINYFIHTGHLNIKGLKMSKSLKNFVKINEALKLNTPRQLRFLFLLHKYNVPMDYDDNTMDEAVGVDAFFNKFFQNVKVLLRETGIENSQKWGEAEKALGKSVLDTKEKVHQALADDLDTPLALRLLQELAKDVNRYMASSPSPVSMAVRSAAEYITRMLRVFGLIQNSSEIGFPLEVGGSQESTLAPVLDIFTEFRDQVRSILFDKDPNVDVKKALMALCDSVRDTKLPHAGVRLEDRAGAGSVWKLADKDELLREIEAKEAEKREKELAKQKRLEEEQRKLAEERERAEIHPADMFKSSGEYSAFNEQGLPTHMANGEPVAKSLLKRLAKEQDKQQKLFDKYHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XIG6</accession>
    <name>A0A6G0XIG6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mediator of RNA polymerase II transcription subunit 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mediator complex subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MED6</name>
        <name evidence="8" type="ORF">Ae201684_004374</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the Mediator complex subunit 6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000054">
        <property type="protein sequence ID" value="KAF0740136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XIG6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003175"/>
    <dbReference type="OrthoDB" id="344220at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.580">
        <property type="entry name" value="Mediator complex, subunit Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007018">
        <property type="entry name" value="Mediator_Med6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038566">
        <property type="entry name" value="Mediator_Med6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13104">
        <property type="entry name" value="MED-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04934">
        <property type="entry name" value="Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0740136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="232" mass="26685" checksum="FB1764E4569DE8E9" modified="2020-08-12" version="1">MEVPRQPAHVDDYYASYRDNVWLGQFELNHQTVLYYFAGSPWYDKSCNNEILKMQRRPLEHLVSMTGIEYELQLNEAKQLPQNLFVIHKKNRTGPRTASVMAIYYVLDQTIYQAPNTYTLLTSRLKKCSYRINKAFKALSAGVRFSPTEGYSWDFSTEEKPVPIIPSEQLAVKLKRKQEKEEKIRQNSAHVDSILFGLVKKYAPDVLESNGVTTEASGTEAEGPATKRQKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XIR9</accession>
    <name>A0A6G0XIR9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">subtilisin</fullName>
            <ecNumber evidence="6">3.4.21.62</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_004387</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Hydrolysis of proteins with broad specificity for peptide bonds, and a preference for a large uncharged residue in P1. Hydrolyzes peptide amides.</text>
            <dbReference type="EC" id="3.4.21.62"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.62" evidence="6"/>
    <dbReference type="EMBL" id="VJMJ01000054">
        <property type="protein sequence ID" value="KAF0740150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XIR9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013411"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF67">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026294955" description="subtilisin" evidence="9">
        <location>
            <begin position="17"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="10">
        <location>
            <begin position="174"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="490"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0740150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="722" mass="74352" checksum="8CCB28BA797A0763" modified="2020-08-12" version="1">MRLFALFAATVAGAATTTRDPKIDPALWTLLQSNQPVDAMVELKQQPASFIESFEIVDPAEQVRKKLMAATSNAAATVKSLLAPSGRRLTESQCPGSAASSHLWIAGRMHVKGLTLCIAQELVADDSVLRLRKQEVEEIDTSAIAQASPVDTLPDLWAADMIRAPLVWDGGNTGEGIVIGSIDTGVRATHSLYASKIRPGYNWFDPINSTATPTDDIGHGTHITGILVGDDGVGIAPGAQWISCRGCGSDCTESALLSCMQFMLCPTDAQGNNADCSKKPHVINNSWGSGVSKSVYLAAFQAWEDAGILAVASNGNLGPSCSTVGSPADYPTALAVGMMTQDYVFNGRSSRGPTKNNTSIIKPDIAAPGFGIYSASYTGDNLYASLSGTSQAAPHVSGTAALMLAANPSLTPAQIRTAMTTHTETASIVLGFGGQNCGNVSDLSFPNNNYGSGLVNASFAVESVVVASSQAPTDSPTPVATEFITDAPTPAVTEAPTDAPTTPAPTEAPTTQAPTDAPTTEAPTTQAPTQAPTDAPTTQAPTTLAPTDAPTTQAPTTQAPTQAPTDAPTTQAPTTQAPTTQAPTTQTPTTQAPTEAPTTQAPTGAPTTQAPIPATTPLVTSSPSTSTVTTKSPTTTSTTDVPTTTATTQVPITTATTRTPMTTIKVPSTTAFTTTTKAPVPTSPANALCPDTCSGCYSTLFNTCFNAYKKVCGIFWSTWCGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJ15</accession>
    <name>A0A6G0XJ15_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_004397</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000054">
        <property type="protein sequence ID" value="KAF0740163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJ15"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006218"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013502"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0229">DNA integration</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="12">
        <location>
            <begin position="96"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0740163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="846" mass="96106" checksum="BDDD243AC919581C" modified="2020-08-12" version="1">MMGYRLVKQDLEEAIYVRKDEPRTLVFKLLNGMYVLQQTKSNQHNKLNHAGFDEVAKIIKRIMNHDEDSTTSQHKCEGCMQGQAKRVSYRNQNHFVAPKPLESLSADLCGPITPKKIHGQKYTSVFTDHASRFIFACLLKSKDETVLHLDELTSELDNQRRDSRISNIYSDGGGEYTSASFRAACTARGIKQKFTNAHTPEENHLAEKTNEYLFNKVRVYMTMSGLPAQLWGYALDHVVYVYSNTPQELLNQRTPYEVLFAKPSRLHMLKTFGCLAYMYVPKSERASKLSNPAVPCVFVGYAKDKLGYLMYNPKKRTIQTSHSVKFDETKLRNARMFLDQDFKAGRLVIPSHDSTGKLALDDEIYKARFTTDQEEAPILESTDKFDGDSAAPNTQSGKRVATRKSARTIKKPKIYEVNSVSNKIVEPQTFRDVDKSEYRRDWIEATNTEYQAMLHNSVWELVPLPADRKALKCKWVWKAKYDADGSLERFKARLCLKGYLQIAGVDFTDTYAPVLRLDSLRLLCALVATLDLETAQLDVNTAFLNGDLDEDIYMEQPERYQVEGKTHLVCKLNKSIYGLKQAPRQWNKKLNDHLASIGFKRCHKEQCIYVMVNNEDRSITYLAVYVDDIVIATSCKKALDAVRSDLTRTFEMSDKGELNFLLGMRIERDRSARTVKISQSTFVEELLVKFHMQGCDSEPTPQGLPADVRPNDNANNLPYRSLTGALQYLVTATRPDIAYAVRFLSSHNHDYNRSHWRMAKRVLKYLQGAKHLGIKYDGGASARPKAFSDADFANDKQDSKSITGSVITMGGGAITYMSKKQSLVGQSTTEVEYRCGGDCEEPNMVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJ35</accession>
    <name>A0A6G0XJ35_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_004296</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000053">
        <property type="protein sequence ID" value="KAF0740297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJ35"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020145"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006626">
        <property type="term" value="P:protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051982">
        <property type="entry name" value="CiliaryAsmbly_MitoImport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45984">
        <property type="entry name" value="RNA (RNA) POLYMERASE II ASSOCIATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45984:SF1">
        <property type="entry name" value="SPAG1 AXONEMAL DYNEIN ASSEMBLY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="297"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="121"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0740297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="409" mass="46374" checksum="52A31F842298D9F7" modified="2020-08-12" version="1">MLAHEPEVDYFSLHKRKHKDVDVDMLDYDYVAKCSDVDTLKNILVVLRSGKEGRYPQLEEAVESRLLQVLPPSETARIMRMKATPSESDVHAEIQALAAWETQMAHTSEALDEARKLSNRSLLPPPRGGGHVACTAPVSSERQPKESTPATQKKSKQTISAYDWRAWEKFDVEAAERELDQEEINRRDEARRQQEAIAEQKAKKRLEAAAMPASVDVEAMSNAERQVCAHREKQKGNESFRAGDNEDAIIFYSRSLVFDPTSAIVHANRALVHLKVKNLSSAEEDCTAAIELDPKYFKAWSRRGMARFRRGKYAEAVADFEEALRLDPSNREVQKLLEKTKSKWASVDGTSSAAAEQTAAKPFKRFEIIDTSDDEQETQAVKEIKATKKTEETKFERFEIIEDDEDDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XK12</accession>
    <name>A0A6G0XK12_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nonsense-mediated mRNA decay factor SMG8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_003944</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMG8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000048">
        <property type="protein sequence ID" value="KAF0740567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XK12"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010265"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019354">
        <property type="entry name" value="SMG8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13091">
        <property type="entry name" value="AMPLIFIED IN BREAST CANCER 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13091:SF0">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY FACTOR SMG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10220">
        <property type="entry name" value="Smg8_Smg9"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0740567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="688" mass="77518" checksum="DA89BEFB975EB644" modified="2020-08-12" version="1">MGDNNEATTTFANRLIGRLVFTQVQDHHSMSIRMFYDLERKTIVLLGLFSGSRSMVKENVYDQQVKMQCDQMKMQLLMFTSSHVLFVVHDHARVSTAETKLFRSLSLAKQQLLQVLKSQQAKASKSSITTSQYAPGRSVPLTVFVFPAPSEALTRSNKASRSTIMSFCKAMEARVHALVKPLRGGVVATVRAKDMSSQSNKERRLFMMDPTHCVVAVTRKAATAECSSVDRMAAVLQDLNLLAPVDLKTLLKPLEDEDNIGMPHAIQFAFKCVDLLLQDAGKDHLLSVAQWLRAFRSIAASIMDDSLNFQSSSSSSSDDITVDFKDSPLTLVETIDMYGTFADDICSRESLLAIKRYQQEKPEKINTEMHLNRVQRVVQEFKRSVGNSNPKIHKYTERIENACQSIWCQGRRLCDATSISNHPCCLLYHDNAATFIQHNSSVYLTVACCCGYSINRLADAFSTDTNRRELWMFECCDRFDHIELPHHPLPLIRLGDFSSYNQVHGFVNVYHGFVPKFTALSPWLRGPDAPIQTKKRTNRKAKAAAVGASNELIAYAGLEYECYMGHRFFFHMPVNHTPLEREATVWPNCDMAIYVQCFQCALSANGEPTEFAQLRRVFAAIPPDQDGIEMHLSIKTEDQALEVFKLLDYPLAADSLLCLTLPYVFSSGDITYRHGDALKLHSRVLQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XK34</accession>
    <name>A0A6G0XK34_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_004041</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000048">
        <property type="protein sequence ID" value="KAF0740670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XK34"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008118"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051915">
        <property type="entry name" value="Cellulose_Degrad_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30620:SF16">
        <property type="entry name" value="LYSOSOMAL BETA GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30620">
        <property type="entry name" value="PERIPLASMIC BETA-GLUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026315827" description="beta-glucosidase" evidence="7">
        <location>
            <begin position="20"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 3 N-terminal" evidence="8">
        <location>
            <begin position="34"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0740670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="166" mass="17868" checksum="FB24B9E14D409130" modified="2020-08-12" version="1">MKLKAPTCLLLCLATLAHGYDLEVPQAIVDKMSVDELIGAMTQVNIDYIMTANKTVNATSVQELADQYVGSMLNTPITDGSDTPPLSAPKWRDVITKIQDIHAKAGRPIVYGLDSVHGANDVKDAVLFPQQINIGATFNPKFAKSMGTVAARDTKAGGMNWLFAHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XL13</accession>
    <name>A0A6G0XL13_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_003615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000041">
        <property type="protein sequence ID" value="KAF0741043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005663"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051880">
        <property type="term" value="F:G-quadruplex DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.680">
        <property type="entry name" value="GOLD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867:SF12">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867">
        <property type="entry name" value="RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GOLD" evidence="2">
        <location>
            <begin position="1798"/>
            <end position="1914"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="40"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="162"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="409"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="613"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="837"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="977"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1090"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1384"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1518"/>
            <end position="1545"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1672"/>
            <end position="1728"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1987"/>
            <end position="2024"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0741043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="2064" mass="231897" checksum="DBE386FCD96BEFFD" modified="2020-08-12" version="1">MSAAELSAHVRGIAEKLRKRAEDASKKHGSEASAGLLVSVEHLLQSAQLMERQQQQLQAAGSSPGSLKEMPTVLRNLQLVAAMLEKKSDEMKSKQAMGPANSLATSASHVRIGIDRLLFVQTWLHEQLRDAFSTEMDWIDAFKQVEAHKPSKNESNDLDIALKASEATISTLQAELEQWKQHHEASRAQQVELMQSWERKEAELNSALERSSSNARQVEALEAALAEERSLSKKLQLDMEALQAHTAKVEQEMQEEWERAVKKSNSLQQQIEELQAKTEAQHQVSVTLSEQLEEESRTVLALKGELSVAKENTEKNKLAEMALVEEFEGKIQALEQALVDKDEALNGAKASEDEANEHLTAKIKTLENELKDIQGELAAAKAAAEKNHAEMVKIEAAAKKEAEVRHKKNLELEQELINVRRQLANAEDDAEKRRLDVQALENEVAAVRRGSILDEDDAQRSRQKIRALEDELTAVRADVAQLEQHLQRAGDDGDTFQAYKTDKVLQLVDSIRRLNDEKAQAKAEVERLQTAHGSAGEQVTQLADAVKTLQAEKAHFEAEIARLETRVATEQRAAKLHLEQVAVLEAQVDKTAQLHTEMRVSHEEAGMAMQETVGKIKDDLVNSRRELQRLEAEKTDWEEREKSIQAELESTKERLNKIDDARSALEISNVELMERCVASAAQAAEFEAQVESLKHQLLEMEETTTATEELDKLKAQVDAIAAEKADAISKLEEELAKWESQQKVLEEQINDLTEQLNAANASNGEDKQQLNDQITALTEQLSGLEEEKVSALNIAQELRLANAHFEAQVNTSQLRYDELAAELQEREKSVEEWTSCKEALLVEKTQLEATIASLNQDLASAQDKISELEFEKLELVELKERTMETLAKHQEFEAKSAEKVQEFVDKINALVNEKTSLESEVKDKNEALERVQNELQAAEAEKLRIIDDHQRHVLNLTNDQKSKELLEELQAEKDAVVAGKQANIDALTAQITDLKSQVENATQSVSELTDRIQASEKERETQQKQFDELEGQLMAVHAGELKHLANQLADLQAEKLALQSDFSAQTEKLAEEIESSQRSAGQIQELMVKINAITSEKAQTQAHSQALEEKISTLEAEKQAIHSQIGELNEKCQLLQTQLQELETEKATIVEDLEAKTTAEAISQEKAKTLQETVDQMQQRVVELEAQQVAAATSQAAANALKEAFAERDSIQTKLTEVETAFEAYKTKAAAALKKAEKRTALLNPMLAEKQQLEFRLTALETERRQVEEKHAAELLGKEDAISRLSALVAEATERAKTIEDIENAVQAAVQAKDVELSSSLESWKAREKELEDEIAEKDSAVAATADELAKTQAEFATLKETLELKTLAVTKCLQEKEAFAATQGELRQRLEEFIQQLNALQKAEVEWKTEKEVFVNQVQALEASLEELKQDGQSQLLIQDLTAQLENASKSIDEINAAKTDAENKLVHIKAELEASVLELAELKKVLESQAKDVAEPRQNGSLVSQSLVEAEKVALEASWKTKLNELQVQLQSAEIKYQEEKASLSSTISLLEHQIKQKEDFVAQNVQVPHHMQVQLVAKDEEIAELKRRLEMEAANEKLAFEATKLLKSQLEEKDNFIALLKQNGELKLNQVKQDVENHWKNVLQEREITISALEQQLPGKPVNDQASEIAHFKSQVAQLLQENESLKKQTPSTVEVDVTSLKEQIAKLQQDNTKYIQSMQSLKETLNEKLHQLATIKAPIHVKTMDELAYAIDHEQRAFAERKELHTIQMSKLKRDAQAWLEIAQAKLEEHTRLQDAIHEKSPPTDDVVVNPLEETLVLKSGVNIKAGSLFELPVVCSPGQTIQWSFRIEEADTDINFALTFGDDDDVVPITRVERLEGTFQVKAPGMLKFEWDNSFSWLNPKTLDYHVSVFEPLTEEALARRKEQEVLKIKIAHLHDRLSLMGKEDQLMDEFGSVLDTPLPSAIELYLEECMAHREMVVVPQLSQVQEKMNALKNMINMYVEEQQELTEATASLAMMLEEVHQERRDLQNTCHLHKTREETIATVQAQLGALEAELQSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XL33</accession>
    <name>A0A6G0XL33_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_003635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000041">
        <property type="protein sequence ID" value="KAF0741063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XL33"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005643"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF15">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0741063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="440" mass="49147" checksum="BBDD811607C27655" modified="2020-08-12" version="1">MAALPCDVVEHIAFFVQDPSDFFSYLEVFADVVGPSLGALWSLSKTHLRHDLWPQLHVRTLDTPTVAAAFRLASSCFPIVHFHKGIDTELVKLCLPLHAAMAWYDDHLTFQRRSSDTLVQFPIANLTMRFQYRRTLTSSSLWTKLPLLTSLRSLTLCGLSCDAIRPLLCYVRDSQLTAFTLVECEGAMCSIDDVTRLTHWLTHAPVTRLSLCGCHFAVDTVTMQKFLHALFSSLTMRHIKTSFRLQGLSSLDLSIPAQLTTLELLNARLDDLSMQRFSNSLRYSQVSLLDMSGSVFTPAMMESLANCLPHTKIKTLRLCHVNLTAGGSSVLSKVLPITQIRKLTLTSNRLTDKNAIDLACAVQLAVDLRELDLCDNAIGTEGAIALVEAICKRSAPMTRLNLSWNKVSSSQIQTHLMPFPWALKACQVLFNSWSKHELPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XLK7</accession>
    <name>A0A6G0XLK7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_003445</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peroxiredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000037">
        <property type="protein sequence ID" value="KAF0741334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XLK7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016730"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1020.10:FF:000003">
        <property type="entry name" value="Peroxiredoxin protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1020.10">
        <property type="entry name" value="Antioxidant, Horf6, Chain A, domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503">
        <property type="entry name" value="MCG48959-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503:SF4">
        <property type="entry name" value="PEROXIREDOXIN-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant" evidence="3">
        <location>
            <begin position="2"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Peroxiredoxin C-terminal" evidence="4">
        <location>
            <begin position="117"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0741334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="176" mass="19990" checksum="19E7FF81B570E963" modified="2020-08-12" version="1">MTELGMLTKLKPQFDARNCRVLGLSISSLKQQARFIDDVNETQDVQINFPIFADESGELSRKLGLIKSSAPGDGFEHFRLPYSAAIILDIDMTARFVFYYPISIGRNLYELIRVLDGLQLAMYNQVVLPTNWKVNDDVFIEPDISSDAAKSLFPHGYHEIKPYFRITPSPAITEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XLU9</accession>
    <name>A0A6G0XLU9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_003467</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000037">
        <property type="protein sequence ID" value="KAF0741357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016714"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038800">
        <property type="entry name" value="CCDC17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33820">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33820:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="317"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="388"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="573"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="866"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="68"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="246"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="604"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="346"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="408"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="879"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="903"/>
            <end position="923"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0741357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1524" mass="169396" checksum="54560767C720C5DD" modified="2020-08-12" version="1">MSFDTAADFANHKAKFCINSDFFDPVKQSLLLAGKTAEPAAVVSFALIQQYLSGGPAAAGADLGKVSLVDLKTTMEKNELEMEKVRRHVKKERMKEKADEVRAFKLKQQQANLMRKQEEDDVAALMLEIEKNKQDELRARMERERIKEELRQLDSAGIVSLEEERKRELLELAKQKEMLLQKEQNTLRDIQALEQRVKEQELQHREEDKALRTKLLDVDDNSKVDVRLKSLRHTHMQRSQLHGAQAATLAQKQSALQEQRAKLEDELNKIGRGDNQLDDKPMLSTAMAFNLDEETRRLEKLAAQFEQDTQKRKETMLALDKAPSVSPIVGDKTQEEQQHEQCSGAKIQTTTSPEKPSEPQTSPEKEPRQATKSASPVVMDSLEKEVLHRQQSNEALKQPRPTTPRQPPASASTYTSPPGAYTHPHPSNQAGNPPPGVLSPHYPGNPPPMWGFPPYPYSFPQAPPSYFPQYAMPSMYPQPLNPYMNGYSGLAATGAAIMGYPPSMFPFVPPYMSMAPHPIVEPLPDPETIKLQQQLEAMKQLKEQRELEMETLRFQQLLDSIQGKMSAVTMENQTQSSPSHEVPAAPVANIQPDEPDSRELKALKLKHAEEMLKLKQQRDLMEEEEKLEALKEQREKRRKEMEDEAAHQEWLANQKRMVMTLRMKKMLAQEQSLDGQELMHLPYDPDAGLALFWDYVLMVPPKVSFLQITYAIYEGSTLRTKHKVLRARECEPHGPTYNRCVLATRRDFDHFPARFDLRLLVEVASVSAPGTDTTSKPTTLGWTTLDLFTASSDGTTQLQEGHFKLPLSHSPLPRITPSTKWNLPTETTNGMAIYVRIVHGAHVDEAASFPIDPDMTAPKYVAPFNPSSSFPAPDKLQMDPSQATISASSRPPTSKATTDAKVSRPPTSTPTAKSASSRPPTSKLAPSPSLRRMPLVNASPGNPTSASIPPARTPTLFEASRDAAAIPPVVESNSFDLDDHVANSSPQQPGNPGEGWIDCDLGNLRHASKQSLFARGDGFDVYIDGARSLPDCVTMTKITCFALNSDMATCNPQQEPTAMATLSSSLFSPSFNLCLEYRAERFNPTLTLLCRIDTVHATTKKPLVVGYTALSLFLESETSNQPTKSTTQDFLLNAGAFQVPIRLGTQLGTYAIDFTAKACDAFLKLPCATLLVRIVPAVKTADGLKCLSRSDVPMGEWVARGIALPPPPYFEKAYDSKASRPALAESKLYQLRVARRRPKTVADGLLAVVDKSTVDTPDKLNAWIEVQLGKKPTASLLDAIDSILQYQPEIGFRVAIDGLVNVPSGCFYKVITCMSPPSPFYQDPKLTEDVRMTVSYDWTSAQSNPEFRDGFFSYRDVAEFPQLAIVFDVRTIKLVKGSWVSSPFGWSYLKLLNAAQCVTAGSFQLPIFNGPLSLDILQHDLSLDQLVAAETSKKKGLIWYMPGSSLCVRLEDGCLANAFPQPLENLTPVGIPAGNSSKYTIDKAIIATQRKKKPLAKLIPDGKTEREFDKELNLAFAKDMDISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XML5</accession>
    <name>A0A6G0XML5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box/LRR-repeat protein 15-like leucin rich repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_003310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000036">
        <property type="protein sequence ID" value="KAF0741634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XML5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011104"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box/LRR-repeat protein 15-like leucin rich repeat" evidence="1">
        <location>
            <begin position="103"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0741634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="319" mass="35774" checksum="3EA154FDBFBC8738" modified="2020-08-12" version="1">MAPTLLDLLARKEIVFNGTKSTEPILARVIAFLGMEPSIGHDKSPACFATTLMLTCTKYFKLATKNPYLFRWMVLRPRWSLSAFERIFDLHKALILSLDLSFCHAYVTDTTIQTLANGCPLLTHCVVWGCHQLSDIGLKGLVSSCRYLTFLNFGGCVKITNASLECIGNELLYLDNLHMSGCPLLNDEGIASLLPASRVVLRVHPCDEPRIPLEFDLHHMKTQLRKFGCSSVNFRVMRDNKHELVLHFKSRPKVVGLWCESTPNKFMPRLTSADNSFHFAGQYVCTSLKVLNIVQCPRISPSAAVTTLKGHHIQLKVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XMY8</accession>
    <name>A0A6G0XMY8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_003117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000035">
        <property type="protein sequence ID" value="KAF0741745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XMY8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019856"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0741745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="106" mass="11918" checksum="1757C01E259E9FC8" modified="2020-08-12" version="1">MGYADGFMQNAPALPKPPRFKGSTKAERRRFMDEYNLYISQTNALTANGIRPFIMPVAACIEPESKHRIALWGFVKNADDVTEAEWISFAQGLVNLFAFRYQAPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XMZ1</accession>
    <name>A0A6G0XMZ1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_003259</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000036">
        <property type="protein sequence ID" value="KAF0741578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XMZ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003289"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF623">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="902"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="216"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="351"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="531"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="268"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="355"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="929"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0741578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1274" mass="141788" checksum="94C9929E7F9A2332" modified="2020-08-12" version="1">MPASERTWYRLICYTFCTCLWVFSFQVVLAVFFVLNLLVAFCTGNFHNVLTRVVRTAWQVELWIHRIYITDTKLPLPRADAIKRGTIWWTFLYFFVWKQIQTAYFASIGASIIANSSANQSTPSVPTPTIDSIPWPEMGLPFPLTTKPSTPSPSTGNESAAKVLIVVVVAFTINIFMVWISTGITQSYYLWLIRDLELPESRQLLPRTEKKPFKLILRIGSPKDDSPDSPRSVSDDMDSPPPSLPLGQHTSSMGSSHSASSGYNRPTSMPPMPPMPPMPPMPPMPPMPPMGPVLPPLDPDQANKSIHPMLHFPSTLTERNGVLGFPVPPPPPVEGAAPSFWNSWLVTPPTLAEKSTPKKDHQLKTPKHKGDPSMVDGKHHVHALRHLISLRKPGGLEEAKLHLEALQRELSRYTDVHDSRRRHLESLCRDFADELHTWESELDVAVTVQRKKAKQDDATMDIARDRLQTLERLWETSDESARDDTLIEHLRNQLLALRAMVSSVPPTRQDRQIFDRHCDALSDNVARFVALQEEKAVRKAHEEEVERRKAAKEGIQAQLNAMRQTLAVAVVLSADQKASLEAICVDLERQLAELAEPLSPPPPTSTVATQPVLQSESIRVKEDRPFAESLVSFGGRPPASKETRRPVAEIVHTAPNDEFNEEDVLYAPKESRFLDVSLKAQSAWLSPSGYVQAPASYGLLSPVASAAASIATYGMLSPLSSPKTRDFDIAPTYRALDAPVKEDNVHFLAFAPPTVCHGMTFQFDIWAFLVNQRQEMLEQATSANPSGRLLSREMLLQIRRGALIHVQLEIPSGFALKSEPTQALEWQGDVSSVTYDVQCTKKASIGQVLFKATIVVGSSVLLLRSYLFVAANVDKDSLSVQELTCELEALPKTFTEIPFNSLQLGDMVGRGNYGDAFLATYQGKEVVVKTIRGDALGDSGDQIVQEFRHEAAVLNMFGHHPHIVPFVGASTDISQPLSLITEYLPHGTIETQYGKRLSYKEKGRILGDVAAGLLNMHEGGFIHRDIAARNCLVDQILRAKVCDFGLCRRVNAYGGSHFDMSVGPLKYMAPESLQPPHAFSYKSDAFSFGVLMWETFIEAKPFASLSAPEAAIRVLEGGRLDNTHPDIPKAYQDLIASCFKEDPMLRPTMTELFDTCRRLQANEPTFQSEEASLLHVIPTKFALRHLVREIKTPETLQCSHFELKLTFHLSSFMASHVYFITGANQGIGYEVVRILSERLGGRAIIAPSTTARLLLSKCKSFNSANVRLLETDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XN84</accession>
    <name>A0A6G0XN84_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_002981</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000033">
        <property type="protein sequence ID" value="KAF0741932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XN84"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013238"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505:SF79">
        <property type="entry name" value="PROTEIN SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="468"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="11"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0741932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="510" mass="55866" checksum="0FCF2D91D977DCA7" modified="2020-08-12" version="1">MGFKLNNVAHIFALLCAINMLNYIDRGIVPGAPVEFQAFVQQTIEKQSFLNSIANSTDRHDTSHVSTYIGVLVSSFIASYSIFICIFGYMSMTRRPFLLSAIGLFIWVIAIVLCGLAKPIKSFYLLLAGRLLSGIGESSFHATTPPFIDEFAPTKSRTLWLGFFYCGISVGTALGYGYGGAMAHIWDWAFYITAIIMFPMAYACWQWIPLHYDYPLAHGAPKELEGIESRPSLAGPGSLNQAEVQAEVSKELNHNSSAIQDIIVIVKGPMFISATLGVAAYSFTLAGMGAFMPAILIGSDILGENIASLAFGGLTVVAGVIGSPLGGWLVDRQSRGHEEDETYRCYIAARQMIVCMTIGVIFGFLALAFMDNTAIFIVCMLLALIFVFTTQAAQTLVILYSVAKHRRGFAMGLNTLFLHVLGDVPSPIVLGALKDAWAPNCGSVWNEKNEAKLDPNCYLDKSGLRNVLLFSVAWLVWSVLTWTASFFIARRRLYNARKDLALAETPVRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XNL7</accession>
    <name>A0A6G0XNL7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_003041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000034">
        <property type="protein sequence ID" value="KAF0741849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XNL7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005478"/>
    <dbReference type="OrthoDB" id="77292at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0741849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="161" mass="17949" checksum="79F4FA18917373AC" modified="2020-08-12" version="1">MHQVFAQLPSYNPFVGSFHHAPSAGNRGAVYFASDIVFASELEMRKKLRQNPFAGTFHALPGYYDPLHGLQKFRKAKNDSLMTSNLLYVQVEYPIQPNHLHHGGSSSSARPRAHSDSDMPSALVSKAKHSRGSRRSSLADAKPKRVRSRSHFHKPHHSASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XP78</accession>
    <name>A0A6G0XP78_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein arginine N-methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_002888</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000030">
        <property type="protein sequence ID" value="KAF0742224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XP78"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014035"/>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016274">
        <property type="term" value="F:protein-arginine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000132">
        <property type="entry name" value="Protein arginine N-methyltransferase PRMT10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF68">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE PRMT10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06325">
        <property type="entry name" value="PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="5">
        <location>
            <begin position="181"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0742224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="368" mass="41589" checksum="F9697DC7A761E34D" modified="2020-08-12" version="1">MADFTPEAKKAWESSSDFANYFCTYGFIYHQKQMLSDTLRMQCYRDAIFENASCFQDKVVLDVGTGSGILAIWAAQAGARKVYAVEATDMALQARRVVASNKQDHVVTVIQSKIEDVQLPEKVDIIISEWMGYFLMRESMFDSVLLARDRWLKEGGALYPSHATMYIAPLGLEQTALKRFSEFSGAMDEWTMFVAETKDLWGVDMSCLGNAFRQEQEQYSLKTSQFVELRPQDVIGEEVPIKHLDLNTCTLEDVVSVNSTFTTVFTNTTRFGAFGGWFDVDFHGSVDNPAVTKVKLSTSPFVQTTHWGQQAFPLSPVQVCEGDSVRGKVEVVRRSDNQRLMNVKFDFEMEYQGEGRAQPVQTAVFQVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XPL7</accession>
    <name>A0A6G0XPL7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA 3'-terminal phosphate cyclase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_002642</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000028">
        <property type="protein sequence ID" value="KAF0742368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XPL7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018983"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003963">
        <property type="term" value="F:RNA-3'-phosphate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000005">
        <property type="entry name" value="TatD family hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023797">
        <property type="entry name" value="RNA3'_phos_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037136">
        <property type="entry name" value="RNA3'_phos_cyclase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000228">
        <property type="entry name" value="RNA3'_term_phos_cyc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020719">
        <property type="entry name" value="RNA3'_term_phos_cycl-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036553">
        <property type="entry name" value="RPTC_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096">
        <property type="entry name" value="RNA 3' TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096:SF0">
        <property type="entry name" value="RNA 3'-TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01137">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01287">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase" evidence="3">
        <location>
            <begin position="304"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0742368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="655" mass="71505" checksum="641D4E1E43D92598" modified="2020-08-12" version="1">MPGDVIDIGVNLLNRQFQKDLPRVLKRSADERVTTIIATGTDIKVSERSVAYIRKRNAPLPRLVCTVGIHPHSAKDAGEDFIAKQSALITKNRDVVVAVGECGLDFNRDFSPRDVQLNVFRQQVQLACDLKMPLFCHERDAHHEFLGVLMPFLETGQLKTSQIVVHCFTGSESELKTYLRLGFYIGLTGFIAMSSRGAALRRCIASIPLGQLMVETDAPFMHPTQSRQRCEPHHIHSVIETIAECMRVPAEEVASATKRNAIRFFNLESPSTPSAISHEPMASPAPQTTTAPTRLVHVDGSKFEGGGQILRLAMPLAAMLKKHVVVHSIRAGRPKPGLGHQHLCGITLLESMSAVWSLEGHHLHSSSVQLIPNNELPWALRGNDFSTSIDTAGAVSLVLQGVLPLLVFAADKEVYQLHLVGGTHSQFAPTVDWIELGLVPLLQKMGIAMDVAMTRRGFMPRGGGQVTVTFPPRQDHRTLLPIVLETPSRQVERVVCRITSGAAATSNAARTSLLKQFRFAFGIDSNVEWSWDLQVDNGLKTPSLSIHVSIELGHGNLLTASVAQTNSTTKAVDSIVADLGRAWDSDGCVDEHLADNALVFMALAAGTSRLRVPKETSSQHIEAAMYVITLVTGVEFTCQTDQKSRLISCVGLGWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XPY6</accession>
    <name>A0A6G0XPY6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleolar GTP-binding protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_002740</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
            <location evidence="1 5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000029">
        <property type="protein sequence ID" value="KAF0742338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XPY6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016017"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01858">
        <property type="entry name" value="NGP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000559">
        <property type="entry name" value="Nuclear/nucleolar GTPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024929">
        <property type="entry name" value="GNL2_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012971">
        <property type="entry name" value="NOG2_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF9">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08153">
        <property type="entry name" value="NGP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="7">
        <location>
            <begin position="218"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="499"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="508"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0742338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="557" mass="62576" checksum="7E671005E721B7C9" modified="2020-08-12" version="1">MPPTKIPKKRMGINTKGASADNPNRKIPKKQKAANMRDKATINRLNMYRNSGPIRNKKGKVVGGSLMMAGRQGGVTMNDASAPSRIAPDRRWFGNTRVVGQKELDKFRNEMNVKAADPYSVVLRTRKLPMGLIQDSTKVTRMKLLETETFEETFGKQRTRKRAKLNGVSDLEALVNRANEEADKYETKGVDRNIEVEVDFKDATSHDVFNKGQSKRIWGELYKVLDCSDVVIQVLDARNVPGTRSEHIERHLRTNASHKHLIYVINKCDLVPNWVTKKWVQILSKTTPTLAFHASLNSPFGKGALINLLRQFAKLHAEKKQISVGLIGYPNVGKSSVINALRKKRVCKVAPIPGETKVWQYITLMRRIFLIDCPGVVYDGVNDGEVETVLKGVVRAEKLPQPAEFILPILERVKKEHIVKVYGIADWKDEVDFLDQLAIKCGKLLPKGEADHNNVAVQVINDFIRGKLPWFIAPPLKPEEQAEIDAGKDVTNEELAAFQTQALKGNGIDDENVDGEEEEVEGEEGEDEEEHGEEEEGDEEEEGEGDENEEEGDEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XQU2</accession>
    <name>A0A6G0XQU2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_002287</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000023">
        <property type="protein sequence ID" value="KAF0742893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020174"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00124">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0518">Myosin</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="8">
        <location>
            <begin position="25"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="9">
        <location>
            <begin position="337"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="252"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="437"/>
            <end position="444"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0742893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1632" mass="183343" checksum="C3085D8AACC31584" modified="2020-08-12" version="1">MMLKKASSSLSSTHSLQIQTQSEGQVAREGWLKKKGHLFSTIKSRFFVLATDGHLAYFKDNKKKKQKGLVVLDMSDTIMPLPTKKHDKVFGFELKKDASGDHNAKAYSLTMFASSDPERTQWIEALRRVTTVQFVPPTPRTPALSVSALSQTVLGTVTSNPRDTFCVLIEIGELQQLVTAAKTTWDIDPLKWSQDQYLELCRSIVFTHEKAANANMSIQESQVLKDALELRYKYEDAQAQVQARRLSVAAPLSPSPQTTKLEEVPEPTSATEHPPAEKTLSDAISLINRPVAKYFASLDPSFVALSPRSKTIAKYAHLYQEEALIAKRAWNILREDSDDVLNAPIVSTTTDDLANLLNERFQRDRIYTNVGNTMLTINPAPRLVHHAAGNSIYDETTVMWYRDHDLAQGSPHPFALAKQTLSSIQDNKQNECIILIGESGSGKTDFGKHVLKYFATVQHALKPPHVQLYTSSTKSTIKMRSDESHLMDLLRSKQITYETIYLDISPEKWPDMLAASGGLKQLPQLHMEKLFFGNYDELQRLEDEEQLVFYLKNPLAARLTSILLDSNILLETFGNARTVHNPNSSRFGKSTTFSVHATTGQLLGGSITPFFLETSRVTNANPDDANFHIFYSLLVGASDKLASECHLKNTTPSTFAYLGKPSKSAPTNVKNFSTEEDRQRWQRVLRCLDLIGVTEVERTAIFSILSAVLYLGNFVFKDSLNALGVATGVKISSAEELKIVASLLSVDINTLERSLCTRQLSVAKKDEVYELQVHEPQARVSRDTLARLLYESLFTTLVSMLNKHSKAHEAIDGKACEITLVDVFGFEDIGFNSFEQLCINYLTERLSSFELDYAGEVQKTLYASEGLQCSWLNDSAISSGYALQVLESPVGVWACLEEATLLHSNEDDQSQAKNSRFVRALYSRNVDHSGLTIRRDPLEFTLNHNRSQVTYNATNFVAKNSDAVSIALVKLVRSSTNSFVKSLRPEPTEKIGEEIKRQSVANRFKGHVQDIIAKLRVARPRFVHCLRPRLDASSDFNSLGLELLKAQIRGQLLPPIVSYSSQQFRHNMELSVFQSRYHMLFKDIFTPNGVEHALNSFVGSLSDSQGASYSFAVGKTTVFMNGLLHDKLQDRRFQVRSSACVVIQATVRMWLASRAVGKLRETTRNYIRDITQFYAKYNPTKLPEVPDIVRAFRGRENVLFEKLQQKYLKDHVETPSEEAIDTSLEDFILKVHFDAITVQQMLLNPKIALLLGEPRILQALREVSIDPSVIYLQTNDPVLRLFYTEMRSYLTTSVVPKRTKYQDMPLEDAVEKLAHLQLLKPLVGMTPEEQDALSEIATDPSLLPFHIDQPGVRTMLQRLIKSIDNDPSTVVAELRFASELSAVRETEPQQEPSSIENIHSACPAESEIDIRPESEPLLSTQSNEDNSVEASENLSHDFAQDITPIDTEKANFSEGNAPIAAKPHELPPQLPRFQDMPLEEAVERLIEAQLLHPINEMTPEDQAIIQEIAMDPPLLAFLIDDPHVQDLLKRLCQLADNKQDQSTHTPNAATLSAQTQAAVPEVVELKRIKITKKLMKKIMNDDKMMTMMGEPKVMEFFEEFSEDPSDLPLISFPANETLLIDFYQAVLQLSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XRK6</accession>
    <name>A0A6G0XRK6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine aminopeptidase S33 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_001984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000020">
        <property type="protein sequence ID" value="KAF0743190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XRK6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011773"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000117">
        <property type="entry name" value="Monoglyceride lipase, putative"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051044">
        <property type="entry name" value="MAG_DAG_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11614">
        <property type="entry name" value="PHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="1">
        <location>
            <begin position="34"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="1">
        <location>
            <begin position="330"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0743190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="589" mass="65403" checksum="989157A5ACFE2639" modified="2020-08-12" version="1">MASFELVESSFVNERNQHIYTRQYIPTGDTFKLVYIFLHGVGEHCTRFDPYFRTVAEQNIAVYALDHHGHGKSEGRRHDCNLFEDFVDDINAFVEIIRTKLVDRPCLKYVISGISFGGLLAAHTAACGEHPWDGVVLAAPAIGLDFTPIVGLQQYFATALSAVVPTAAIVPAVKSELLSRDGDFVKDYDSDPLNAHGNLKMRLAAEISKGMKTLEPIQSHISVPILILHGDADKVTSPTVSRAFFDALPSQHKTYESRPGQFHCLFNEPEKAGNMSIILDWLNELHQRPDLTARRLYPQTTFTFSESSFVNGRDQTIYTRQYIPSSSYNRVLLFLHGLGEHCSRYDSMFATLASQGIAVYTMDHHGHGKSDGERHDCNVFEDFVLDINQFAMEIRDQHADTNCFYFVGGISFGGLLAAHVAASGIHPWDGVVLAAPAIGLDYTPIVAMEVYFAEALSSVVPTAAIVPAVDINMLSRNKSFIHHAEADPLNAHGKLKMRLAADIAKGMKSLEILKKNVTMPIVIFHGDADVVTSPTVSKKFYEEIPSTNKSYVSLAGNYHNIFAEPEKDETIRSFVEWVKNPRVLLEVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XT61</accession>
    <name>A0A6G0XT61_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_001471</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MINDY deubiquitinase family. FAM188 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XT61"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002709"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990380">
        <property type="term" value="F:K48-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025257">
        <property type="entry name" value="MINDY-3/4_CD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039785">
        <property type="entry name" value="MINY3/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12473">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE MINDY-4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12473:SF8">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE MINDY-4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13898">
        <property type="entry name" value="MINDY-3_4_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01174">
        <property type="entry name" value="DUF4205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="3">
        <location>
            <begin position="108"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="287"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="299"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0743825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="672" mass="73786" checksum="BC38A0325D900231" modified="2020-08-12" version="1">MSGVDDVQQQSELLVMDYLRTSRCMKTMDALSKWISDKSKKKQRSASSPTASDIFAKDVAANKSNKERANSVLEYMIGMRKTSPKSPKVSCSPEGAVKVNETTAATTPTNATSAEWTKADLAKLKKEAKKTQHITDKTERWKVVGAALGRSKRECHDKYKEMRKKSKEKVAQCTDDDPIMLDLTDNAIAESAPTPRNSVNVQVAQSVKERTSSAKKYKHKVDVMAQEDDSWCSSAGDAKPKGRAGAVVAPGDISSVRRVDRRENDGDAVVEDCEDLDNIIDARLTMKKEPPAPPGMSILTKSGTSRRTVRTSQGQASSIRRRRCASKVALQRSPEEIEHSLDKAGTSFPPSQELMECCQGFSFSTVDGLRYGIVQHEGGPCGVMAVVQAYVLYYLFKEDSATWQDASRDQMQSALVLALTHIMWQAANGLTCKIALEGTAPALEHILVSQLNSRHELEKFISVHIRDYADPTGYGVVLLVASVILSRGISVIEADMDSPDGTTPTLIGAHDYCTQEMVNVLLLGYACSNVFDGSKDLSEDDKTGSGMVLRGVQRPNLVGFLTLFEAYDYMVVGDHLKQPHDNIWVVCSESHYSVFFADPAAPALDNTSTFDLFHFDGLANQDEVIRLTVDPQGLPSKPEKAQPKDLIPPLNLVIQTKWPCATIDWNGVEPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XVS3</accession>
    <name>A0A6G0XVS3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_001215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XVS3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021776"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF132">
        <property type="entry name" value="PROTEIN-LYSINE METHYLTRANSFERASE C42C1.13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="47"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0744760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="487" mass="54065" checksum="610CAFBCADD69A00" modified="2020-08-12" version="1">MELSEERNAAANTLYKEGRYVDARQEYTAAYNSLKGIDGLEVNLLRSRILANRAQTYLQERDYGLALRDAQEAVECDPSNFKARMRQIVACENLEKFEAALEHVRALLKLPIEGSTLTFALTTQTRLKRNCKTDAAAAKAQKYDIGKLVHDQQSLRLNFGSAVPSELPVGHWFDLVIFAANEFGLFQRGLISSPVPLSCVFHTPAPGVALEMDPVQLELGLNGKATVRLRINPSSHVNFDELPVISIRASVDKGFQLDDVLPVVSLPIQLTKETFDDMTVDPLGLQCCRCVYVDPVDKYITLAESPGNLGIGGKLWDSSLILTAYLAAHPDIVRHRRAIELGSGIGLVGMSCAYLGVKTVILTDIDDVAPLLAYNVRLNDLQDQVAVQALWWGTSVEMLEPPFDVVLMSDVVYDPTGYEPLVQSLKDLSTPSTTILMGHRSRHPQEKEFFNLLQAVFTLNEIPIDSAVWSHPSRMTDVKLFLIQKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XWU9</accession>
    <name>A0A6G0XWU9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_000246</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XWU9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006944"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050478">
        <property type="entry name" value="Ethylene_sulfur-biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795:SF39">
        <property type="entry name" value="AMINOTRANSFERASE CLASS I_CLASSII DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795">
        <property type="entry name" value="BIFUNCTIONAL ASPARTATE AMINOTRANSFERASE AND GLUTAMATE/ASPARTATE-PREPHENATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00753">
        <property type="entry name" value="ACCSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="3">
        <location>
            <begin position="50"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0745213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="434" mass="47600" checksum="7C173E593FBEEAEF" modified="2020-08-12" version="1">MALKAKADLSLRGKRALQPALSYFEMVLKALENEATDANPDGYVPIAVSENRILNAPKMLSKLNECCAAATDKSSLGYGDFSGRQGFKEAYAGFVNATLMKSNEKTINPKHLAVSSGVGSLLAHLSSLLHDEGDAVLLPTPTYAALYNDFYVASGTKVINVPMTPDYDITTAQLQVAYDQAVADGHIPKSVLLLNPENPLGIVRSQETLRDINDWCVEKGLHLILDEIYANSIHSPDQSAHPFMSGASLFDLNTSPSFVELPHHVHILWGLSKDWAASGLRVGVVYTSNPDLLAALSNVLYFSGVSNYLLDGLAHMLNDLKWSLDFIAENNATLHASYSRVTSVLARYGIPYVHASAGLFVWIDLSAYLPEATWQGEQALTRRLFDECKIIMTPGESQHAPKPGFYRICFAYNTANLIEQALTRTFEFLTKQQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XWV3</accession>
    <name>A0A6G0XWV3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">General transcription factor 3C polypeptide 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_000551</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000003">
        <property type="protein sequence ID" value="KAF0744966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XWV3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003445"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039340">
        <property type="entry name" value="Tfc4/TFIIIC-102/Sfc4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23082:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23082">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIIC TFIIIC , POLYPEPTIDE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="127"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="161"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="387"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="471"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="482"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0744966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="910" mass="103851" checksum="4D2944D1D93562AB" modified="2020-08-12" version="1">MSFQSLLAKALSEDEQDMPSSDSMYEDSGSESDFSEEEEDNAKPRRKRKTDETFLEDEDHSDLERQMWGKRRQSGRGKRRVRRRTANPVPPEYAQLMGEANAAYISGDHVKAISMLKDFVKKAPTVPDPYHTLGVIYEKLNDRLKAIQFFLIACSLTPTDASLWRRVGSMAKEEGNSEQATYCYKMATQADPKDVETLYIYAEMCKEGGDNRRAAEALKKIANLTPEDLSVWLQVAECYHANSQDDDAIEALVACIEQASDHPDGSQYELHAVNMVSDLFITLKRYDDAIQAIEALHRRRNTSTSIEEAPTTVPLDIAVKYGICHLYRNHIDKAQIMFEVLFQQDVDIYGDLYIDVAEAYVAAGPEHDSTAIEILQNVLLCPTFTSDKVFAMLAHAYERQEVLDTALQFYDQALEYQTQTKIDPRLVLRAMNICYATKATARGLQFFEYVRDDVMLPPIRPYWAQSTTLSTLSSTTSKPEEEIIEQENPPTDDEDDDEDDDDMSESGDESGFSEDAMENIIRLKLFLIYARLQWQQGEPEALCKVALPVILLSLQQTSRLLGRKSLLRRMHKYYDSKSLEARDLDRFNITHSHVLSAMKDTYLVNPSDPTTRDTLVGIVMRVTEQVLVVKTLTEPEYVALVRDVCRALCEVKKHICAVELLIDVNCSNKISAANLRFELRFLALSIALAHKENRMAYECVRLNILEEPENYGYWNLFGHVINQTGVFSWHQKFLAKILRQHPKCYPAMVLAGLHSSASDSAQLAVGELTLAHLQRPDDPLALFCIGLSYLNMSMFRTVVDRQLTVAKAFAFFQLYQEKRFKQLQDNVSGLTSETGQVESWYNIGRAYHQLELNHLAIAMYERVLRFYEGKEIPPEYQLCRETAYNLSLIYKQSGAVDLARYLTHTYLTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XX68</accession>
    <name>A0A6G0XX68_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_000357</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat WDR55 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XX68"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006855"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050505">
        <property type="entry name" value="WDR55/POC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019:SF20">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24796">
        <property type="entry name" value="WDR55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="56"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="306"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="306"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="330"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="354"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0745330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="363" mass="40595" checksum="4F3A52D2653959E3" modified="2020-08-12" version="1">MEVTQEAGGIPDIELPSDVFDLDFHPTGNIVAAGMIDGKVQAYQYSPEGNTSVLSLNHHQDACRIVMFSEDGNALYTASSDKSIRAYDTHGGVLWAELNAHLHPVNQLHRISNNIITSGDDQGCVKMWDVRQRRCVVEWNEHTDYISDMTTNDAKDTLLVTGGDGRLSVYDLKKNKFVQKSDELDDELLSVKIIKNGRKVVCGSQDGVLVIFSWDTWGDMSDRFPGHPDSVETILKVDEDTILTGSSDGIIRVVQIHPNKLLGLIGDHEDMPVEVLKFSHDKRIVGSVSHTNKVHFWDVGYLYDEDDGEDDEDDGEETKGLQFDPKSDDSMDESDDDDDDDIDQARQGRQAFPTKREAFFSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XXV0</accession>
    <name>A0A6G0XXV0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_000412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XXV0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006217"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21581">
        <property type="entry name" value="D-ALANYL-D-ALANINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21581:SF6">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0745392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="677" mass="74723" checksum="B832CA0DA83BC664" modified="2020-08-12" version="1">MSQGYDSSQLPYPGPPAQNYAPPVATDQPPRRSTAASPFASGPVATVNQVRPAAGFPGPPRPAPFRPQSSSQLNTPLGQKLGVEAPSPSLFPTTNTPSYPPPQFPTHQFETTPLDNPASNPFHTANLNGPETYLVPGTSIQQEDPFQHLPDPSLPVTSSQFQAPPPPSAAAIPQDPFSSNFNTVDSTGSDPFGTEPNLFARPPPVPIARRDSFNNPFETAPPMIDPFKQLQYQQSSAPPPPAAPFLNYNTNPSPQYMASPTMFSQTPPAASPKVDFKPPPSPQPQVPSEIITPARTVESLMDEFLSKVAPDKWPTAPANIYQLPNTIECLQDLHQQQLWQQLESKAWSMLGTSDPKFNLHVHAWAMVALMKQGKVDDLEQQIIVLGDLDREQYRYESYPELFQSKTGSFVPIRLRFIATQVPRLKNNSSMYETMASQLFVDLQKNSFNLPPQEAAIWHQIVGVNMVNSFVERKKFDLALRLAKSLYNVKRDDVDLRQRIVLLSRLGRINLQMGDFKGAEAIFAEAAWVNQHIAANEPDCAARILLNQGLLAFAQNKFKEALDAFNTILGVYSGEEAINGSSNEPFESWDDGDVISCAANNMSICALYSCEVQTAVNVLETILQADPRRHLHSSIVFNLSTLYDLVCDNANSTSRKEMIKRLSEAYGIEHIDATSFRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XY56</accession>
    <name>A0A6G0XY56_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_000132</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000001">
        <property type="protein sequence ID" value="KAF0745681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XY56"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011371"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026104266" evidence="2">
        <location>
            <begin position="17"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0745681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="359" mass="38638" checksum="260ECF124D96269D" modified="2020-08-12" version="1">MKVLSLVALMASSVSAVYWNQSAGYNVAVDFTGWSNFSPINGGCVTCPYTCVRPSTGPDGLALNFSNASAMQNLPAVYSQVKSNGCCYAKGKVMPSCSATASPPESEDCGFLYGPTLKWNITDTQNPPATKSPVRAILMASTDCKNFWAVQQTYVKEEGKTPGLKITGSKQINGGCYGSSTGAAIILAGCLTADLKFDKSSSYSWDKLATKCRGLAGVCTRTNALWGRNLECCTDAVSIDASKWDIENYKLYNQVSKTGIELSGPAITGIVFGGVALMMALVHFGAKVHRRAQQTALMREQEANDDYEEVMTPLTAAEKTHGMSMARSIGPNHVEHSLHEGDQIYKKKDDEVLFEGDLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W435</accession>
    <name>A0A6G0W435_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_018959</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000369">
        <property type="protein sequence ID" value="KAF0721719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W435"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019500"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="179"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0721719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="228" mass="26229" checksum="2F2DACC204350830" modified="2020-08-12" version="1">MPRQGERISVLRGIEGYVKQHLLQYPYPPSWVKKQIRHLLGVYRSVLSVRYLQQRCELTKSLGALSILPHLSVNDFEQEVRVSQDTFAFILGHIENSTVFANSSSNTQASDTTAVVLLVEWWGEQKELAKEPLSSIQIESSKLAMILQYHGSNGLQLQNDIVYYQLMERILYCLKSPTLDGEVYYSRKKTYSMNTILTFDFERQIRYVVAGWPGSVHDSTIWKTTDVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W5B3</accession>
    <name>A0A6G0W5B3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_018492</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000337">
        <property type="protein sequence ID" value="KAF0722365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W5B3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014521"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.239.10">
        <property type="entry name" value="Elicitin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036470">
        <property type="entry name" value="Elicitin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48647">
        <property type="entry name" value="Fungal elicitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0722365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="151" mass="17210" checksum="0AFEE14E8B1BE492" modified="2020-08-12" version="1">MRFLHKHGVTLALWIASAALVWYTFFPKGFVAQKPDQVGLDALPFCLNLPDLQRYFVPIMEDERAAKCRLEAGYTFKVQLGLVLPATKSQIRAFFASPACKDYFEILLDVYVNKLPDCRLQLNKTASVPNSAFKNVSYDMLKELHEAYLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W7A5</accession>
    <name>A0A6G0W7A5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_017974</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000318">
        <property type="protein sequence ID" value="KAF0723010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W7A5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014702"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026089007" evidence="2">
        <location>
            <begin position="25"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0723010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="248" mass="26782" checksum="AA58E70526DAD509" modified="2020-08-12" version="1">MGTTVIHRATNLSSVAVIATCALAWIHDQPNDSIAVEDVIYVAQADQINRVLRGNVKPIGPELSKQEKSGEKWGHWLGKAGGGRVGMAIGTATAGGELAGKKYAPKIGAKIGRFFGNREAKKGKQILKELTERNTELKAVSDKRSRISLNQPRPLMKRIIRSNSAASSVSYEKGQEPNPNANQPANQRQPNPASKTVSGDHDEHGDVQQPSIHASFLRLRLRKKLKTKPKKRPLGVAVLVVAVDAVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W7N8</accession>
    <name>A0A6G0W7N8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_017786</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000312">
        <property type="protein sequence ID" value="KAF0723267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W7N8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018097"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="START" evidence="6">
        <location>
            <begin position="142"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="5">
        <location>
            <begin position="259"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0723267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="386" mass="44048" checksum="2B2CD601B9AEC144" modified="2020-08-12" version="1">MPLTTPLPSDYFRCPPLSQDDIDHFIELGNRSMQALVKKADLVSGPYRWKLLKDESELKIYKAYNAADDSHLHCGVMQVVGDLDENMALHRDDTTEQAREYIQRFGRVYADVVNLYTVLPRHPERPNDAVGIKWFLGKSPRRDFVMLETEFEFQANGKRAWVRSYSSIELAAVPDMRKELSCIRATMYDTVFVVVESDRRGYLDMTYLADMDVKGQAPAWVIDTTLKFWLRSMHDVDRCMRENRLSRTLFLKTDQLYPLHSRRSCALCRRKFGPLRKKTNCLKCGEVLCTSCNRLWNVNMNGLDAQVRACVTCSLGTSTMALRKTAISQPNPSPEQLALQTLAWSTGTLVQAPPLDYDDDTLSDGLSSYGNSELDSRARPISLYTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W8F5</accession>
    <name>A0A6G0W8F5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_017673</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000307">
        <property type="protein sequence ID" value="KAF0723443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W8F5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017382"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0723443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="439" mass="50184" checksum="286D02EE5F53EBCE" modified="2020-08-12" version="1">MAVLPVEVLVKIAFSIKDVEDLFAFLEALRPYDMLGPLAHLYELFTTRHHLGLWPSLALHPTILDSSERPLYEGITKYYEHVVVENVWSDVEWLKTYLSPMAQIGWNLKDIDMYLTSISLDEWTDLRITRLALDIEDEDEAIWCTNAVSQLPSLTCLEADISSFELEDFFANLAASQQITQLHLSFDEYQLTAFDLAHLTEWLRHQPVRHLGCEFGDWEDLDLDVKETFYQAMFNCPTMAILELSGCKVDDVDFAQYDFPMRSLVLHQCCLSSRQVEALVSRLERSKMTSLQLTDFTFDYMDGIVSLLEIQPRTRIQHLALGGLHKYVATWSILAPSIEKLTVERLIFCATEFPSDAAESLAMAIQNNPSICELHLNCCDITLSGLVLLIQSITHPSRQTKSKRVRWTAQQVQFPDPEIFQALVELAVDSGGEFVYEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W922</accession>
    <name>A0A6G0W922_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_017461</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000297">
        <property type="protein sequence ID" value="KAF0723686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W922"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004676"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000019">
        <property type="entry name" value="DNA excision repair protein ERCC-6-like 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="338"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="704"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="41"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="110"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="140"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="237"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="272"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0723686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="962" mass="107442" checksum="B5D027FDBF9FED0A" modified="2020-08-12" version="1">MDLIPSSDEEDNAAISSSYGLLYKTPAVSQYARSMPITKAVFSSDEDKETDAIQPAFKSKPQLCLSSSSDSSDDETLPASTSTSSDNIKISAIEYLLKINANARNLPVFRRMIPPPKSPPKPKRASSPVKPANRSLELKSTPATTQSTSSSLSKSTPVTTQSPSSSPSIMQPPKTFTKKRPRSPELPAHTTPVAPRLPPPPAPVYISPFGRQKQAADAMPPPPPRRRLSVPAKSIEDDWFSDEIEDEEPSRSSSKKSTVTGRKQQRKKPLDIPKLPKLPLTDTKNPPPLPKPLTSVELDEISQDKTVYWPQLPSLADTPSNGPLVLLDTPEQTVQAFNFYFKLCRGAILGDDMGLGKTVQLLSLLSAVLHKDGTLRDKQRRENAPSCPILIVVPASLVANWELECKVWLCASLVVLQGKPKDRLEILESIPSFEIVICSYDMLKVHLSDLQAISWFLIVMDEMHLLKNPESKITQAVQRLVCKRKLGLSGTLMQNNADELHCVLDTIQSGCLGTLVEFRGFYIDDIKLARKKSAAPQAIARSEAKERHLRQLLEPYYLRRDKAVNPQFQQIHKHDQVVLCPLTSLQRAVYERVTSLPEYEALMDPETKEVDPGVLWHHVHPTGEKCAQCPLICLQFLAMTQLLKIANHLDLIRVNPSDSKEQQEATKAFAKVAFGPHLDEVGGVDQASGLFEKMNASLCGKMQVLAELLERWRRKREKALIFSRNTRMLDILQSFMISKALDYVRLDGGTKVDERLKLVQQFNKDPSLGVFLISTKAGGLGLNITSATNVVVFDPSWNPAHDCQAQDRAYRIGQTKDVHVYRLITLGTIEEMIYARQIYKQHMSDTTLEGKKAPRYFEAIQGVKSQQGELFGLKNLLQFQPQGVMKTIQDNKNNKPDFIVLDNDVHFDMTQAPPPSTANLNDKDWQLVEELDLSQAVKPTPSTKTTPIEPKKRNLYIPQYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W9Y6</accession>
    <name>A0A6G0W9Y6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_017969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000318">
        <property type="protein sequence ID" value="KAF0723005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W9Y6"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0723005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="153" mass="16599" checksum="C195A74DDBD3960A" modified="2020-08-12" version="1">MGSLFISQSVGGDIRQTLQQATSPVLPPRDDDRVVGFLHSSIFHLANMRVLLSLVVAATAVLALNQEQVNEPIAIEDTRALSAAHFRGKLRSFRHRRSFGRGGFGGPPGGFGGGTGEADETVRVLEAAGRSRRGRRRGRSRRRGRRSGRRNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WAJ1</accession>
    <name>A0A6G0WAJ1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_017276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000292">
        <property type="protein sequence ID" value="KAF0723895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WAJ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020775"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17731">
        <property type="entry name" value="BRCT_TopBP1_rpt2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09620">
        <property type="entry name" value="CBM9_like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059215">
        <property type="entry name" value="BRCT2_TopBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010502">
        <property type="entry name" value="Carb-bd_dom_fam9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35532:SF5">
        <property type="entry name" value="CARBOHYDRATE-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35532">
        <property type="entry name" value="SIMILAR TO POLYHYDROXYALKANOATE DEPOLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06452">
        <property type="entry name" value="CBM9_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="1">
        <location>
            <begin position="50"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0723895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="490" mass="56444" checksum="A12DF694F56E019A" modified="2020-08-12" version="1">MPYCEWVEESQGNIRTGVDAASRATSFRVDDAQGTRMLTKWCCRSDWTIFELKPLEGLCICTTGLYVEDRDKDQELCESMGGVYHPDLIFGTTTHLIAEHSEGAKYIAAIAYGIPIVTVDWIVACLDAQVRQMTKSAEWEYMATLDPPKYPCVRRPEGGRKGRMDLDGRLDKPEWANAVWTDRFVDIEGPARKPNPTLETRVKMMWDDEYLYVGAEMEEPRVWGTYTEKNTVMYHENDFEIFVDPDGSRHNYYEFEMNCLNTIWELVLHRPYKDGHSIDNPSNLTDIHSAVYIDGKPNDPSVVCKKWSVEVAIPLNEMVKFDEIRRRKVQAGDTWRMNFSRVHYDLNVQDGQYVKVPNRREYNFVWSPTGVIDIHRPEKWAYVVFLPSVAIDEPTWRNVCASLDSDRAVEDLLQKIYYEQREFHAAHSHYAATLAALCPDFEEPYVVSLEVADDKQSYIAKAIGSDGKPRSIRHDSKFLVDLHPVDVHGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WAU0</accession>
    <name>A0A6G0WAU0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_016939</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000273">
        <property type="protein sequence ID" value="KAF0724274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WAU0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021524"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0724274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="126" mass="14496" checksum="4871C2020F5E8A01" modified="2020-08-12" version="1">MDLSDLICKYAYKQCSNPRSIKRDGDLHRLCAYHREKANALQKAYATKRRRELREQKKEDWSYDIEPMPYVLSTSSIGESDLDSIEPTDLDCLFDDLYSPIAVAAPALSDSLKDEQFQCETAHQLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WB83</accession>
    <name>A0A6G0WB83_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_017571</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000302">
        <property type="protein sequence ID" value="KAF0723558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WB83"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016061"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0723558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="23234" checksum="9A145FFD5BBB4D75" modified="2020-08-12" version="1">MSTTASRVSYNSEIDDTPAIIEYIWCGENVGLELVRPVLSDAKPISHVWKEGELGIIFAIDFFAKKVYVRRVTKQIDSIKTKYLLHTVNSIPVTAENYQEMMVVLKSGRDAGQPQTLEFLPRPQPVMVKSIPPAGELEKAGVTTDYELAMINNINVDNLSMDQIGRMLQDSNKPCHMTFGLPVHAEKDAIEAMLARLDLNNSSDIVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WBL7</accession>
    <name>A0A6G0WBL7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_016722</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000266">
        <property type="protein sequence ID" value="KAF0724658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WBL7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010787"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071818">
        <property type="term" value="C:BAT3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15204">
        <property type="entry name" value="LARGE PROLINE-RICH PROTEIN BAG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15204:SF0">
        <property type="entry name" value="LARGE PROLINE-RICH PROTEIN BAG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="23"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0724658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="597" mass="65430" checksum="BA16AC5269D588C6" modified="2020-08-12" version="1">MNTSMHENDSSDGVGSSSDNAMMNLKLKFIHEEAIALTVERDISISNLKQRIFDTTGTAIDLQRLIYKGKVLRDHLCLYNYNFVDGDTIHVVASQRPTTPPVPSPAPSTQASVEDHVDPGQMSFQSLMETLVGSNDDTGSRSTARRGSPFIAMTFEPPPRMRTSNTPSRSTARRDFTTPQDLLEQAIHLRQAATRLSSLPMISLHPHQARLASSLNEFSHSLLILSRQVSSLAWALNRLDSERDLEDASIQGAISETLNLLGELGAFSTPLRQALSDLVRPPPTRSITVVDIVRVPEENTNRPAEPPSGNLILTLLQAVGNAVRGTRDAMDEGNSRSRTTALPAPPAASTSASTNTARVQEVHEHEMEGAMSTFIDARTPLLANDTPLTVVLDVVYGLMQSYFVPPHPLHALPEEFVAGLHRPLQHVVQSALGFSDQVAPSYLNKRIKTWAKAATRQYEGWLADALSSEAHVNLPQDCSDGMHCRLFVRLANLILLPPSSHSVFASEMQLLGRRFLSALLHVLLNLPSPSDAVVSALVQKIVYKTTEAARENDVINSDRVVVIRHVLHSVMHDQTEALFTHTLAVTQETPTSSQINV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WBW1</accession>
    <name>A0A6G0WBW1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_016525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000256">
        <property type="protein sequence ID" value="KAF0724905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WBW1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000561"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0724905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="172" mass="19979" checksum="173749EB9D76774A" modified="2020-08-12" version="1">MAWKRPRRELMSLLWMPSSIVQQIALYIPVAKDFLSFLASFPDVTSLGDLQYFLELSYDLRPIDLWPKLQLDELTASLVPSVRRITRFFTTIYVLEMFDLKLLQQCLHPHNVVELLKCPTWIMNGLEEWLTTPISILPVQHMTICRMSNVICLLFLDQLGSMPHLVSLSLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WCQ0</accession>
    <name>A0A6G0WCQ0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_016250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000247">
        <property type="protein sequence ID" value="KAF0725233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WCQ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005786"/>
    <dbReference type="OrthoDB" id="61553at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0725233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="231" mass="25153" checksum="7612128733293E79" modified="2020-08-12" version="1">MDIGDGITSIYLVIFAVVVVPLSLYVSFRGLRAPKLSALLSIISICFVFSYSIALISDIAFYFGLTAIPILALVVWCVDGSSPILVAAALPLHMVYTIYSMFLVQTVTNGYVQFGIPSNTSWVTCLFVAIFLAIATGFFMLYADEEPQRYMFVASSSTTGIFFGIHYVGAIFSGRLVLTAADYFKIFALRPWICWPVALVLTGLAVYTQLETIPATTAASTEEIKPLVAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WEK5</accession>
    <name>A0A6G0WEK5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_015784</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000232">
        <property type="protein sequence ID" value="KAF0725819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004385"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000289">
        <property type="entry name" value="ABC transporter G family member 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000528">
        <property type="entry name" value="ABC transporter G family member 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="441"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="506"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="542"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="575"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="665"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1080"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1112"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1152"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1191"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1221"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1321"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="70"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="743"/>
            <end position="984"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0725819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1348" mass="150615" checksum="7CA45F57AB43E9CE" modified="2020-08-12" version="1">MPTLKSADSFLADGSDKFHEMLANNLEAASRKAMPQVEIRFKDLAIAADVVVATKDGANELPTLVNTVTKAVMGLAKTKRVFHKDIIHPISGVLKPATMTLLLGQPGSGKSSFMKMLAGRFHEEKNITVGGNVLFNGTKREEVKKQIPQFVSYVNQRDYHFPMMTVQETMEFAHQACGGKVPQRVLDSLNSGTPEEIEQAKEIIEALYQVYPDIIVRQMGLTICKDTIVGDAMTRGVSGGERKRVTIGEMEFGMKQVSLLDEISTGLDSAATFDIVKSQRSMAKSLKKTIVIALLQPSPEVFDLFDDVMIMNEGYMMYHGPQSEALSYFESFGFKCPPGRDVADFLLDLGTPQQHQYAVPGINNQPRYPADYSALFQESTIYRYMMEHVEGPVHPLLLHDGAHHVQNAPEFQLDFKTSTLNLVRRQTQVLYRNKVFIQSRVLMILLMGFLYSTTFYQVDPNSAQVMYGVIFQAILFLGLGQIALLPSNFDSRAIYYKQRSANFYRTSSFVIAQTITLLPMSICEAVVFGSIIYWVSGLVSDVGAFFIFELILLITNVLFATWFFFIAVVTPNLDVANPVAMVCVLFFIIFAGFIVQSGDIPDYLIWIYWIDPIMWAMRALATNQYSNSEFKVCNYRDVEYCATNGGKTMGTVQLEQFGMPTGREWIWYAVIYMVALYFVFVGLSIIGLERIRYDNVHGTLSEEQLMDEEDEKEAYKEMPATPVGSQASDSVIVPVQEFVPVTLAFKDLHYFVPNPTKGEPDLELLKGVSGYALPGTVTALMGSSGAGKTTLMDVIAGRKTGGKIVGDILLNGYKATDLAIRRCTGYCEQMDIHCESATFREAFVFSSMLRQSSDIPTATKLAHAEECLRLLEMHTIADSIIRGSSVEQMKRLTIGVELAAAPSVLFLDEPTSGLDARSAKIIMTGIRKIASTGRTVVCTIHQPSKEVFEMFDNLLLLKRGGYTVFFGELGHESANLMEYFMRIPRTPSMALGYNPATWMLEVIGAGVETKVTNTTDYVEVFQESEEYKQLQAGLAIHTLPRADVPEMNFSTKRAASNVVQFQYVLVRYFRMYWRTPTYNLTRVMLSVFLAVLFGLIFVSVDYTTYSGVVGGSGMVFMTTVFVGIIAFNSVVPIAVEERASYYRERASQTYNALWYFLAGTIVEIPYVLVTTLIFTVIFYPFVGFSGSVGNVIVYWLLLSLYSLFNVYMGQLFAYALPTMDVAMSIGALFNSIFILFMGFNPPTSAIPKGYKWLATITPPKYSLSVLVAEIFAKCENGNGMGCVTMSGVPPATLSQMNKTSVTVKEFTEFFFEMKYDNGTKYTLIVFAVIILFRILTVLALRYINHQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WEW7</accession>
    <name>A0A6G0WEW7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_016526</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000256">
        <property type="protein sequence ID" value="KAF0724906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WEW7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000560"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052394">
        <property type="entry name" value="LRR-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0724906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="184" mass="20154" checksum="48C45CB607E69083" modified="2020-08-12" version="1">MFPARLCMQSLEWSYCSLNLTTMAALATALRHSNMTSLTLDTTNIDVATLPTLLDALLETNLRRLKLSKASLEDDACVLIAAALPSLTIVELNLSYNKLTDHSAKVLAEVVGRATSLTSLVLYDNAIGLQGATTLVKALSGRPQVTTWLDLGWNLFNHDEADWLNDMVEKTPQILKACFDQCRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WFC5</accession>
    <name>A0A6G0WFC5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_015610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000227">
        <property type="protein sequence ID" value="KAF0726060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WFC5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003396"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33977">
        <property type="entry name" value="ZINC ION BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33977:SF1">
        <property type="entry name" value="ZINC ION BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MULE transposase" evidence="1">
        <location>
            <begin position="112"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0726060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="298" mass="34200" checksum="9ECAD6DD988DF941" modified="2020-08-12" version="1">MGTTPSQALSKLTATVPPAQMPPLKTLQNCYRYFRHHNMQEHSNTSVMTHLLVERFFHTGLDENQAFSFGYNIVDGYPSIGYGGSDGPFKVGITTMSLLRRMDRDPSGFLFHWDATYKLNVKAYPVLVCGITDVARNFHPVAFFILGKESESEYAWAIESLMEIFTKVTGRQLLLTYVMADAGRAPALAIESRRNPLGVANVLMCFYHVISNVQKRLAGTSPRTKALVYRYIYYMHYSRSYHELLFNWQRTLPAWNSNVELTSRRFSGYFDEQWISSRSWQWQAYHTPPGFPATTGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WFE7</accession>
    <name>A0A6G0WFE7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_015550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000224">
        <property type="protein sequence ID" value="KAF0726147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WFE7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021670"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0726147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="162" mass="18769" checksum="16BE4260701118C3" modified="2020-08-12" version="1">MESHLEFPEEEYSKEIEDRLYPITKSDVRKQLERIRKRQINPTREEILRSLNLSEADSHLLLAPADIEDETLCLKWFADTLEKCDEARRASRDFNNTRKHPLARVSWIDPNPYAVLDMDDLTDVAEHDDGEDSSSTSFEDEKLPSDCVTYLPDIPTLCSGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WFE9</accession>
    <name>A0A6G0WFE9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Aconitate hydratase, mitochondrial</fullName>
            <shortName evidence="12">Aconitase</shortName>
            <ecNumber evidence="12">4.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ae201684_015579</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.3" evidence="12"/>
    <dbReference type="EMBL" id="VJMJ01000225">
        <property type="protein sequence ID" value="KAF0726120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WFE9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020764"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01584">
        <property type="entry name" value="AcnA_Mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000002">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000003">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000004">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1060.10:FF:000001">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1060.10">
        <property type="entry name" value="Aconitase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050926">
        <property type="entry name" value="Aconitase/IPM_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015932">
        <property type="entry name" value="Aconitase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006248">
        <property type="entry name" value="Aconitase_mito-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01340">
        <property type="entry name" value="aconitase_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005558">
        <property type="entry name" value="PRK07229.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160">
        <property type="entry name" value="ACONITATE HYDRATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160:SF3">
        <property type="entry name" value="ACONITATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0408">Iron</keyword>
    <keyword evidence="8 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="13">
        <location>
            <begin position="64"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="14">
        <location>
            <begin position="581"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF0726120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="778" mass="83392" checksum="236A9E3DEA85C7F0" modified="2020-08-12" version="1">MMLTRSAPRLQAISRASTRAASTSTPLSVLDPKGSATIEETYAKMEKNIGIVRKTLDRPLTLSEKIIYGHLDDPNFGVPKRGETYLKLRPDRVAMQDATAQMAVLQFISSGLPKTAVPTTIHCDHLITAEKGSTIDLNTAKDVNKEVYDFLASAGAKFGMGFWRPGSGIIHQIVLENYAFPGGLMIGTDSHTVNAGGLGMCAIGVGGADAVDVMAGMAWELKAPKVIGVKLTGKLSGWTSPKDVILKVADILTVKGGTGAIVEYFGPGVESISCTGMGTICNMGAEIGATCSTFPYTQRMADYLHATNRSGLASAADSFKANLAADAGAQYDQIIEINLDELKPLLNGPFTPDRANLAGKGIKEASEANGWPTELSAGLIGSCTNSSYEDLSRCADLTEQAKKAGLKFKVPYYVTPGSEQVRATIARDGILDTFLEAGGTVLANACGPCIGQWNRTDIPMGTKNSIVTSYNRNFAKRADGNPETHAFVTSPELVTVCSIAGTTTFDPENDTIKTPDGKEFKFDAPHGKELPPRGFDAGEDTFQPPPADGTKLTVKVSPTSDRLALLEPFNEWDGKDFLNLPVLIKAKGKCTTDHISMAGPWLKYRGHLDNISNNMLIGAVNAETDKTNEVLHHFTGKYDKVPAVARAYKAEGISWVVVGDENYGEGSSREHAALEPRHLGGRAVIVKSFARIHETNLKKQGMLPLTFANPADYDKISGTDKISIVGLDKFAPGKPLTLKVTPKSGATFDVIVNHTFNQEQIEWFKNGSALNLMKKLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WFL8</accession>
    <name>A0A6G0WFL8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Lon protease homolog, mitochondrial</fullName>
            <ecNumber evidence="10">3.4.21.53</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Ae201684_015817</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homohexamer or homoheptamer. Organized in a ring with a central cavity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 11 14 15">Belongs to the peptidase S16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="10"/>
    <dbReference type="EMBL" id="VJMJ01000232">
        <property type="protein sequence ID" value="KAF0725855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WFL8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019406"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070407">
        <property type="term" value="P:oxidation-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd19500">
        <property type="entry name" value="RecA-like_Lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000021">
        <property type="entry name" value="Lon protease homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.5270:FF:000001">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1480:FF:000002">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000015">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03120">
        <property type="entry name" value="lonm_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054594">
        <property type="entry name" value="Lon_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027503">
        <property type="entry name" value="Lonm_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43718">
        <property type="entry name" value="LON PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43718:SF2">
        <property type="entry name" value="LON PROTEASE HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22667">
        <property type="entry name" value="Lon_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001174">
        <property type="entry name" value="Lon_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00830">
        <property type="entry name" value="ENDOLAPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 10 11" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 11" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="17">
        <location>
            <begin position="73"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="16">
        <location>
            <begin position="710"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="active site" evidence="10 12 14">
        <location>
            <position position="799"/>
        </location>
    </feature>
    <feature type="active site" evidence="10 12 14">
        <location>
            <position position="842"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <begin position="460"/>
            <end position="467"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF0725855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="893" mass="99081" checksum="4A0ADF4AA7360B03" modified="2020-08-12" version="1">MRITQAAVAGIHRCFGQSKLPLARSPFRLPGPRWSRAFSDMRGDDDGEDDDDVTAKTIATFGEGDKAPMVPHVLVIPTHKRPLFPGVVLPMTVTNPDVVKALASLRESGQKYVGVFLKKPTSKNGSASKEEMGFTGMESQKDEDLVTDLSAIHHVGSYARIDNHLSFESNNAAQLLLVGQRRITIDDVYDSGSLPLRVSISPLENPTFDKQNQMIKAYSNEIVAALREIVKMNPLFKEHMQYYSQRIDIHNPYILADFAASVTTGDGDELQSVLEEMDCENRLKKALELLTKEMELSRVQQSIKEQVEEKVTKNQRQYLLMEQLKTIKKELGMEKDDKEAMLSKFRQRLDAFQIPASEENPEPSSHIPKEVLDVVEDEMAKLSMLEKNSSEFNVTRNYLDWLTLLPWGKSTTESFDIVAAKAILDADHYGLSDVKQRILEFIAVSKLLGKVQGRIICLVGPPGVGKTSIGKSIARSLNREFYRFSVGGLSDVAEIKGHRRTYIGAMPGKVIQCLKTTQSSNPLILIDEIDKLGRGYQGDPASALLELLDPSQNTSFVDHYLDVPVDLSRVLFVCTANVTDTIPGPLLDRMELIRLSGYDAPEKVAIAQQYLVPKALEKSGLKDSEHTPSSLELPEESIQDLVKRYCREAGVRNLEQHIEKIFRKVALEVVENLAKEEKDQPDSSTFHISPDKLHKYVGQPRFTSERMYETLQPGVVMGLAWTAMGGSSLYIETTTVQSKGGKGSLMTTGQMGSVMEESTKIAHTYARHKLELIDPENSFFEADLHLHVPEGATPKDGPSAGCTMVTALMSLALNKPVKANLAMTGELSLTGKVLPVGGIKEKTIAARRSGVTTLVLPAGNRKDFEELPDHLKEGLDVHFANVYDDVYHVAFET</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WFP8</accession>
    <name>A0A6G0WFP8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_016200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000244">
        <property type="protein sequence ID" value="KAF0725303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WFP8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005212"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="227"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0725303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="455" mass="49710" checksum="09117E2173D31E45" modified="2020-08-12" version="1">MDRMNKAKAYPMPVSMQSRYEKHDFQTEQHPSSPRSAPTQAPATTNTQTVPSTPAPKLTAHSTFSALRKNTPSDPSKSLALGKETGVGFRPSSPVTADDKDISFDPSTPPRPKAGPSSQPPPGLLSHFKSKKTSSAQKALNFANKSPIAQPLFREENITTDNPLDESSFGAKPSTINSPPLAPMASLDSPRREAPLSHFKAKLQLNDTDKPATEVLNRRAFNALMEAPSIPSTSSSSGTAAPSAPPSHFKPRPQETEPSSAQKPRPPANLLRKSETMSPLSDAMLPPPRSDPSPRASSPSAPAPEAFPLHLQATLRQYLDEAMYTSKFSLAGARVVFADIPTHLPLARQKAIYWLAKANVEEEHKAWQSAEQVYKDGLAILAHPLERLIIEAAQLEFQSRLQLTRQPMSLQPINIVVPNQKTQLTPEKQREFCSHLLDGTQEDSFIMENPRAMIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WFW2</accession>
    <name>A0A6G0WFW2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_016151</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000243">
        <property type="protein sequence ID" value="KAF0725380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WFW2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009929"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026288482" description="GOLD domain-containing protein" evidence="9">
        <location>
            <begin position="17"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="10">
        <location>
            <begin position="26"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0725380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="199" mass="22415" checksum="9A0373137B0C3003" modified="2020-08-12" version="1">MRRLLVFVLTAAVVAAITTEVHSGLPECYFLDAQKYKEGLSLNYEVVRGMGDELETTLSSPSGITLFHKTGTLGRFVSPVPEDGAYRVCFTQKTFVTIRVGFSFHADDPAHDVVSNADATKIEQARAVEDMVYELNTNLDTVKDTQSYMKAKSVYHHSIIESTNSRVMMWSCIEAVVLIGLALWQMSYLRRTFEVRRVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WG45</accession>
    <name>A0A6G0WG45_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 12">tRNA(His) guanylyltransferase</fullName>
            <ecNumber evidence="2 12">2.7.7.79</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">tRNA-histidine guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Ae201684_015732</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>a 5'-end ribonucleotide-tRNA(His) + GTP + ATP + H2O = a 5'-end phospho-guanosine-ribonucleotide-tRNA(His) + AMP + 2 diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54564"/>
            <dbReference type="Rhea" id="RHEA-COMP:14193"/>
            <dbReference type="Rhea" id="RHEA-COMP:14917"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:141847"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.7.79"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the tRNA(His) guanylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.79" evidence="2 12"/>
    <dbReference type="EMBL" id="VJMJ01000230">
        <property type="protein sequence ID" value="KAF0725963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WG45"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006649"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008193">
        <property type="term" value="F:tRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3000:FF:000001">
        <property type="entry name" value="tRNA(His) guanylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025845">
        <property type="entry name" value="Thg1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024956">
        <property type="entry name" value="tRNAHis_GuaTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007537">
        <property type="entry name" value="tRNAHis_GuaTrfase_Thg1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038469">
        <property type="entry name" value="tRNAHis_GuaTrfase_Thg1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12729">
        <property type="entry name" value="TRNA(HIS) GUANYLYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12729:SF6">
        <property type="entry name" value="TRNA(HIS) GUANYLYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04446">
        <property type="entry name" value="Thg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14413">
        <property type="entry name" value="Thg1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028980">
        <property type="entry name" value="tRNAHis_guanylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8 12 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 12" id="KW-0819">tRNA processing</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="tRNAHis guanylyltransferase catalytic" evidence="16">
        <location>
            <begin position="6"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Thg1 C-terminal" evidence="17">
        <location>
            <begin position="139"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="29"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="75"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR028980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR028980-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR028980-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF14413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF0725963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="241" mass="28174" checksum="4F9EAEC9BF42DE53" modified="2020-08-12" version="1">MANSRFEYVRSFELPDPVLRNTWIVVRVDGKGFHKFTQAHGYAKPNDARGLHLMNRCAKTLMHEFGDIFLAYGQSDEYSFVLSKSSNLYNRRSTKLASTFVSLFTSAFVFYWTEYFESTPMLYPPSFDSRVVCYPSVHNLRDYMSWRHVDCHINNLYNTCFWALVQTGGRTPKQAEEELQHTESKHKHELLFTQFGINYNDISPMFKRGSTLVRSPDKSITVHHVDLIKDTEFWTAHCPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WH06</accession>
    <name>A0A6G0WH06_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">Ae201684_015310</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000216">
        <property type="protein sequence ID" value="KAF0726422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WH06"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012381"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0229">DNA integration</keyword>
    <keyword evidence="16" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="14" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="15" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="19">
        <location>
            <begin position="255"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="532"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF0726422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="792" mass="90158" checksum="AEFE16EDD97190D6" modified="2020-08-12" version="1">MAKRQSLPAKRVKPSDSSDSCASDSEATRSFSVNAISSKTTMQLKENDFDGMPTLEKHWTLDNCATGHVSGNKALFDAWHGTAELILPNKMTIIGKVGQVTISMLQGGASSTLILRNVTYEPTLYKNLISHVKLLESGYQLYHQDLDGTLYVNPSTKHELKFTMQNNLYVLRDVISQSPNTSHLEVHAIATKSKTNDEKLVHWHNKLNHADFTQVAKVIKPILDPAVDSTTTRQLCYGCAQGQAKRISFRNTHHDIATKLLESLNGDLCGPIRPRTIHHEKYTSMFVDQASRYIFGKLLKKKNETTTHFTELTAHLDNQLRDSRIANIYTDGGGEYTSQEFRAACLSRGVTQKFTNADTPEENHLAEKTNEFVFNKIRVYMTLSGLPATLWGHCFEYVVYVYNHTPQELLNQRTPYEVLFGKPSRLHMLKTFGCLAFKFVPKSQRDGKLTNPATPCVFLGYATEQLGYKLWNPKDQTVTVSRSVTFDESKIRNANMFANSKFNHGRLSIPNYKLIEGVTSLEDLTTERFRTETTAEQTGNQATKPHHEAQTRRSDRKAKRPRRFEVNQVEFQAPQSPLAPKRINAPTTMAEFRSSPEREQWQQAMDDEYNSLTQNRVWELTELPKGRKALKCKWIWKVKYLANGAVERFKARLCVKGFLQIAGVDFTDTYAPVLRLDSLRVLCAVIATQDLEAVQMDIKTAFLNGNLDEEIFMEQPEGYTQPHSKHLVCLLKKSLYGLKQSPRQWHKKLHALLVKIGFRQCYKDQCIYVKRSTTNNCITYLAMYVDDIIIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WIP6</accession>
    <name>A0A6G0WIP6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_014828</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000202">
        <property type="protein sequence ID" value="KAF0727091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WIP6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019089"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF214">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026243224" description="Protein kinase domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="224"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0727091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="499" mass="55172" checksum="892DBAAF03AC2B54" modified="2020-08-12" version="1">MTFAWVAMPLVGMLAHGVDGRAAMRVAAATATTSSSSSLLLSLSVCVGAVCAVLLIAFCSSRKQRQQKVELLLTQQRRMTQIQHGYAAPEGALKSTRSNMTVQSVARGFSGPVDEIKLRSEDISVGSRPQNKRSAGLSSHNGSSSHHSYQHQSHSQVVASQPDVIRMGSYRNGLYTSQPSGGSGSTGSRGHPARLIASQTETSGAVSDPYEETLEMWRLDEAHVKTISLLSRGSYGEVWFGEYRGTPVAVKKLLASRSTHDEMKKFVAEIVLMTKLDSQYIVKFIGVSWFRKAEMMLIIEYMDQGDLRSILEQTNRDSFPLEDKLNCALAIMEGLVYLHTLNTTIIHRDIKSRNVLLDSRKGTKLTDFGVSRETTSETMTIGIGTYRWMAPEILTDSHYSHAADIYSFGVIMAELDTHLLPYSDQLTEKGKPLNDTSIMGRVMQGSIQPTFSSLYPAPLLGLAKQCLSYRPEDRPTSMEIAHHLRQFQKRYASARLSYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WIQ9</accession>
    <name>A0A6G0WIQ9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_014822</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000202">
        <property type="protein sequence ID" value="KAF0727085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WIQ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005571"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005572"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="469"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="564"/>
            <end position="854"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0727085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="860" mass="95125" checksum="B848C57297594CFD" modified="2020-08-12" version="1">MIAPKTSAFIGEPGIYTAEQLAKWKEITDSVHAKGGKIFAQTWHGGRAVHPDNNDGAEIVAPSAIAIEGEVHTLKGKAPNAVPRALKKEEIPAIVETFATAAKNAIEVAGFDGVEIHGANGYLIDQFLRDGSNQRTDEYGGSLENRTRFLTEVLAAVTKAVGADKVGIRYSPLNSYNSMKDSNPEALSEAVAKISQDFNLAYVHVMRADFFQAQKGDIVPIFRKNFKNTLIVNMGYTKDEANAAIAAGEVDAVAFGTGFLANPDLPARFAQNAELNTPDANTFYVVCLLLSLLHLKHLSSSVCMRYERRQLVVALDSCATAQTAYSNGLAVCNYIPQKSCGDSSCLHNNQIWCNATICSSVLAISKNTSASCQLTPAIPQQLCNSQCLATMLQLEQLYTTCSKKPPTLDSCTACQSIMTSETHLSNTCGLVNSTAAMRVSLAAAISICQANFPQILMAPTTTTDANPQLIAIILVVGLIVIISVLSLVFMQYRKYRQARRRSSILRSSLQRRRTSILSFESQDPYILKSPSDYDVELTSPKYSIIEDVRFDKKFTQFRIPVEDFKQKTHLKSGGHALLFRALWKERDVAIKQIAPSHAKDFHALQEFMREIRLSAYLRHEHIVEFLGISWLTLKDISIVTEYMVHGDVSSVLRSQRQAANPWLHWYAPPTKPEVVQTIQLGFQHRLSPCKLSIALHVIRALVYLHANHVVHRDIKSKNVVLDTMYTAKLCDFGISRRISAVMTANRGTVSYMAPEVFQGNKYSEMADIYSFGVFLSEMDKLDSPYVGEKDDDMDADVSFPEAKIALMVTAGTLKPTFTDAMPREILDLAQRCLEFDATLRPTAVQLEKDIESLIKSHPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WKI9</accession>
    <name>A0A6G0WKI9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TAZ-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_014229</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000188">
        <property type="protein sequence ID" value="KAF0727792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WKI9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019129"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05162">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1020.10">
        <property type="entry name" value="TAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035898">
        <property type="entry name" value="TAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000197">
        <property type="entry name" value="Znf_TAZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02135">
        <property type="entry name" value="zf-TAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57933">
        <property type="entry name" value="TAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TAZ-type" evidence="4">
        <location>
            <begin position="180"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0727792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="432" mass="48960" checksum="BD675D0D9655D70B" modified="2020-08-12" version="1">MTSFFRGWTRTNSVATAVPRPAFDAKRTWRRVFTVIKMIRMLRVLGAQAASRRAFLEKQHQAMYGSSNRPRCATPGCPSDWYYVQKNGHCTSCNANRTRMDFNMMETIRKAWSRLTFRKPKDETHAGLSDEEYAMMLGVEWNAQAQEQYPNTLKLIHNLNQFPPHVNQNANLNANMVDDLVKHSSACNLAEQGQVCTVGGCTEMRRILQHTSMHPNAEPNCTDCIKTYRILMSHAERCQVECNVPRCAAVKKHIECRSATSPPTPQMCWVRTPEMSWWPAIVYPLHYPLPQLPLYVVDQYQDGYHVVCCLGDRQFACVPSTQILPWTQPAAQASTDQLCNHLACEDLRGCVGYPAACVFASLDQQKMAMMHHSSIPAPSVQLAAPQRTRLPSLPSLLSRQPQATPEYDGAFTSPEVHMKKRKLIQAIPQHRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WL36</accession>
    <name>A0A6G0WL36_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ODAD1 central coiled coil region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_014118</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000184">
        <property type="protein sequence ID" value="KAF0728012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WL36"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008925"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051876">
        <property type="entry name" value="ODA-DC/CCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049258">
        <property type="entry name" value="ODAD1_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21694">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21694:SF18">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21773">
        <property type="entry name" value="ODAD1_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ODAD1 central coiled coil region" evidence="4">
        <location>
            <begin position="77"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="441"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="34"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="286"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0728012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="530" mass="60882" checksum="12B432E7DFCC7C27" modified="2020-08-12" version="1">MSQQAIRAQNDYIFSLQVQADKYTRLLGTVNLRIRAIEDEWKNVKAKLAELRHKRNEGDQRGGGINAVKSKIMSESREVSKLENRLAACRMRESKLCATNAELKRKIDALRASRLFSQSVFEKNQKRLRDIQRQMQETFKHSTSIMAERDKIVAQVQSLSNMNIEEQEAFDDIYQNLAMIITRENENAEAFRKEAMKSEGLDTHDDGYFRGNYRLDEEADMKLTLQKLDISLREDQAAIESVSERLKVHESTFKSIMKLVGCDDYQKLVELYTKKEEENFALFRYVQTINNECEQLEEQTAAIQQERQKYADELKEGSANMRKRLIESLEETRQKIKKENSDYERLRQSAQREFLPIARAVDKLYNSLGCNEMIPPSTGAVAGSSTKANDDRNAMMIRMSSMNDLLAAHGITEGNILQFLAIIEQRSNDLIEQFTRRLQHKNPENLGTTSLGAHLQPSDPYRANGLHLNFNLNQTPPLLHEGNEQDNNSDEDDSLVPVSTAELQKKAAKSLALQLNTKLSPQRNKKKKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WLN5</accession>
    <name>A0A6G0WLN5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">W2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_013881</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000180">
        <property type="protein sequence ID" value="KAF0728230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WLN5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003020"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071074">
        <property type="term" value="F:eukaryotic initiation factor eIF2 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11561">
        <property type="entry name" value="W2_eIF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.350:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.170:FF:000002">
        <property type="entry name" value="Eukaryotic translation initiation factor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001:SF7">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00515">
        <property type="entry name" value="eIF5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="Translation initiation factor 2 beta, aIF2beta, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="Zinc-binding domain of translation initiation factor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="W2" evidence="7">
        <location>
            <begin position="269"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="147"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="192"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0728230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="437" mass="48506" checksum="5168C5B9886847EA" modified="2020-08-12" version="1">MSNINIAGTTPVDDPEYRYKMPRLQAKIEGRGNGIKTVVVNAVDIASALHRTPGEVTKFFGTELGAQSKYDEATERAVVNGAFDAAAMQAQLSKFIELFVLCPNCRLPETKYKFKGKESIFHKCLACGAVEPVDMNHKLTTYLLKEHSAAKRAKKAETSEKDAKKEKKSKKKDADADDEPKKEKKEKKEKKEKKDGEKKEKKSKKKQDSDEDGSHGAEEEEEEIEWHTDLSAEAVAARAKEAEALEAAAHAAMTSAATEDVTATFDNLEIDDEAAIEAATESITAYLASPHSSDEIVDEVIRLQTSAALPVNDRLSIFFASAFTNQILSSNHVSKYRPVLEKLVDNERSQYQVIALVEHFCAVKHPALLASFPVVLKLLYDEDIVSEDVILAWTDDENRKMHAHHEVTAAQAAALKKSLAPFIEWLENAEEESEEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WLT4</accession>
    <name>A0A6G0WLT4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alcohol dehydrogenase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_013909</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000180">
        <property type="protein sequence ID" value="KAF0728258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WLT4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017357"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="3">
        <location>
            <begin position="29"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0728258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="206" mass="22430" checksum="9C1FAA46FDAEC208" modified="2020-08-12" version="1">MALFHHLAIPQKTPTTTKKSVLILNGAGGVGSIAIQLLKTLTDVTIIATASRPQSTAWGKELGADDVVNHAGDIPTQLKDIGIPQVDYILNNTYIEPYFDAIVEVTKPLGKISSIIPPLENLPLQNLFHKSVIINWECMFTRSLYTTDNIVEQHRLLNHVSELVDAKKIRSTATDSLGKINAENLKKGHAAIETGRSVGKMVLAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WM79</accession>
    <name>A0A6G0WM79_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_013790</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000178">
        <property type="protein sequence ID" value="KAF0728427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WM79"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018949"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12232">
        <property type="entry name" value="RRM3_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000097">
        <property type="entry name" value="U2 snRNP auxiliary factor large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23139">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="18"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="167"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="269"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0728427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="368" mass="39852" checksum="4BB84C768566CAA6" modified="2020-08-12" version="1">MSQSQNSLSTAISLKPMRELYVGNLPPNVTATQLQDFLGTIIQQVGLALQGQPGNPILSTWISTDGQYAFCEMRTVEECNLALMLNQLNLLGKQLKFGRPRSFVGPPQPMPTVSNRTQTALVNLGCIPNPMWFAGGSAACGLKEAGLLQDNNAFEEIGQIPPDNTSNRLLMANIPTVLTEEQVAQLVEPFGTLAAFTLVKNAEGESVGSALFEYEDDSVTEAAMNGLNGLDLGGHVVVVQRASKQGTLPKYNPNKKVEEKAEEEEKPTPVIQLGNMVQASELEDDDEFADLKEDIEEECNKFGKVVALEIPRPNGNETVLGVGKVFVRFEDISGAQAAIKALKGRKFGGNIVEVSYMSLAKFETQDFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WMT7</accession>
    <name>A0A6G0WMT7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_013595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000175">
        <property type="protein sequence ID" value="KAF0728636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WMT7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002182"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0728636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="185" mass="20629" checksum="936EB444C1A495CF" modified="2020-08-12" version="1">MLNKIKDQPKCLEQHVHDLKTKKCLCCARDYPGITLDELNQYVEEHGPLVNPLFGEQPAFFIDEDHFTPYRMAVYGCAIVVAKIAELVGDWAKAFQVNLVFGLSGRESDGLPEAVDHVDAPHAKGFYLPQVQSERYPRLSGLAMLSARSVSARSMPARSLPISSKTNWPLTPLTTESTLSAYKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WMU1</accession>
    <name>A0A6G0WMU1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_013618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000175">
        <property type="protein sequence ID" value="KAF0728660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WMU1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005560"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0728660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="149" mass="16835" checksum="8E435D26456BBDB5" modified="2020-08-12" version="1">MAVSTFASGIGGVRGNSSDDDDDDDVATDAMNENENESATEMGEDISSEEELPKKRKGDELPPLRERRSVGFAIAKSIQDWIQLERESSAPKSLALSVESTRAIELLNKEYSHQTSDDGIWQLRTISCWMRQRHSFFFFYQRVVDVMHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WNX4</accession>
    <name>A0A6G0WNX4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_013217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000169">
        <property type="protein sequence ID" value="KAF0729080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WNX4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020350"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020351"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="173"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="95"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="266"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="336"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0729080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="438" mass="49653" checksum="BF63455E94B8AC13" modified="2020-08-12" version="1">MTSFLEGYVRQLTQSTAEDILTPVTVKSVLDDMVSDVETWVFETERHALTAELDEMRAQLAQCARTERMHWDEKQNMLNQISFLQVQGKALALKLRHEADLVAQEIEDKERLERELLESKEKIASFANVSRELARSQREVRDLYRRQSIQSMLKISPAHKANPPLKAKAGGILGLQDKHLLIIFAFVGARDVLAISLTCHSWRSRIHTLFGLETKPSPASAAPKTQPLKLKPAPVLDKAQLAKADEMMKSFNAKEMKLFHDLVVRLKGLEANMVSLQAEKEDLAARLQGAENVRDFLMDKLTDAEDALTFSLGEKAKVEAQSSLDREVMAYLDSKAQDLEAVAQSYAVQNEELKVELDRLQREHDAKSQVIEDMIRHLTAEKNDIELQSKAQKKVLVKEVRTLRAENARLAMECNGYRAQLKQLKSSLMSLETFDTNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WPM6</accession>
    <name>A0A6G0WPM6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_013049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000166">
        <property type="protein sequence ID" value="KAF0729303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WPM6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018379"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0729303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="77" mass="8626" checksum="3109A308B150254F" modified="2020-08-12" version="1">MDDSKERCEGEFPRGHHICVIVSDALSPIERWASCELPREGAIDDKLENLEWWACAVLGGGLLLLGIVEFIAVRLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WPP2</accession>
    <name>A0A6G0WPP2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_013070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000166">
        <property type="protein sequence ID" value="KAF0729324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WPP2"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0729324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="109" mass="12641" checksum="99D2F907E819E85C" modified="2020-08-12" version="1">MQHEEAPREIAATSSSCDKVWWDKTNPCFDLPPIKRRLVFSCAGSEIKRKLVFTAHRVVKPRPTKRELQREAEAKLRDQGATNNTRPTDDVSTPYFSKLGRRKRQLVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WS58</accession>
    <name>A0A6G0WS58_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="2">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_012309</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="2"/>
    <dbReference type="EMBL" id="VJMJ01000155">
        <property type="protein sequence ID" value="KAF0730309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WS58"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018369"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05168">
        <property type="entry name" value="PI4Kc_III_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000038">
        <property type="entry name" value="Phosphatidylinositol 4-kinase beta 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000016">
        <property type="entry name" value="PIK1p Phosphatidylinositol 4-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057754">
        <property type="entry name" value="PI4-kinase_beta/PIK1_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF22">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="41"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="6">
        <location>
            <begin position="549"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0730309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="836" mass="94459" checksum="044C27754F844ADE" modified="2020-08-12" version="1">MLSLGAVTKIWSFPSCHCRSCHCRRTTMMMGSNNDAERPPRIKIEGCLYVRLGKRRRRYCVLAGRTLSIFASKEEAVDKAPARKTCCVVGVKDMGELQRGTKETLVGPGLFHNAIIVSTLKSKLLVVEADTKTEKDRWLHAMMSLNFCSEDAERGLVRESLNQPDFDAQLAVTLLYKFRDNSDATDMVVDHLTQYAHNNIDDVRRFVEFYLPQIVHLLVHADTNMDKLIGLLLSICKAKSYVAHLGNSIHLALHLFWLLEAMIHDCRGTPTYNLVAKLLMSIEAQVVNQHCDLKDLIVLFRDVPGLKDTIVAKKDSETREAAPTDNAATNGISLSESEKHTLLQWMEQERMKRYKYFHQERDFIQALTAISETMRHMEPREARKVALPGILNKLVIPEMAYIPLGRASDPFCRVVRVLEHEGTVFSTHSRAPCLLCFEVVEEPSHPSPSSSSAWTQAPRLAATSEMSMFEDDAETLQCIQTNLALHFGSAAVDVDENTRDEDDNASTAHSIKDVVGQSIQTTIMRRTSRTAYDTGLAKLMLLETAVFGESWIAKKKRLQEASPFGHLKGWNIISLISKSNDDMRQEVFALQLIAKIQDIFRDARLPLWLRSYRIVSTGHSTGLIETITDAPSLDALKKRKDFTTLRNHFDKTYGASPIARTSALHNYVHSLAAYSLVCYILQVKDRHNGNILLDTQGHLVHIDFGFLLGIAPGGNWSLESQPPFKLTKEIVEVLGGPHSPLFAKFVQLFTLGFLALQRNADKIITMVEIMMHKSTFPCFQNRDVVKELAKLRDRFVETLPLDVTVKHAVKLVKLSYKNKWTKRYDQFQKITNGILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WSA0</accession>
    <name>A0A6G0WSA0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">endo-1,4-beta-xylanase</fullName>
            <ecNumber evidence="4">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_012296</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 11 (cellulase G) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="VJMJ01000155">
        <property type="protein sequence ID" value="KAF0730295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WSA0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021866"/>
    <dbReference type="UniPathway" id="UPA00114"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033119">
        <property type="entry name" value="GH11_AS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033123">
        <property type="entry name" value="GH11_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001137">
        <property type="entry name" value="Glyco_hydro_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828:SF2">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00457">
        <property type="entry name" value="Glyco_hydro_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00777">
        <property type="entry name" value="GH11_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51761">
        <property type="entry name" value="GH11_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0858">Xylan degradation</keyword>
    <feature type="domain" description="GH11" evidence="11">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0730295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="104" mass="11519" checksum="87BC54C74725A506" modified="2020-08-12" version="1">MFLHLDSSPFFANVRDGGISTYDIFERTRTYAPSIGTATFKQYWSVRQNHRSSGTVTVGNHFNAWSKLGLSLGSTFDYQIVATEGYFSSGYAQITVSAGNSTRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WSA9</accession>
    <name>A0A6G0WSA9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_012361</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000155">
        <property type="protein sequence ID" value="KAF0730368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WSA9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012509"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052769">
        <property type="entry name" value="TPR_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46014">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46014:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="705"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="208"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="649"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="657"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0730368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="724" mass="79868" checksum="1F184B6BA5B2BAAA" modified="2020-08-12" version="1">MTDYSKWDKLEDSDDEKEVQNSRAPAAAASTPAVPSALQQMEALRSKAQVHMEKGEFAQGYTIYKDLLDGASKDTPAGFIESCRMNSAIALIKLERYQEVIPICTEVLNANPQLTKALHFRGHAFMQAGFVEEAEKDLKAAKAALPNDEGIDGDLAQLEVAKVADTSLKALVTDANEKFQAGNIPDAIAIFKTALAEAEKVKRRDVCGAVYGSLGMIYFKNEQFREAIPHFVKALQDLPHPERRIEFLEGLAACHTQLGEGEMCIKALESAIMIGVQAGAPPPRMVKLLLHGVRSCGMLKLTEPGITYAKKAREIATAAQQWDVVFQCNEWIARLHTENEDPDSALIHITEAFQEGVARTDVQSCRALMHIQMHVLKITDPMKHIELVQSTRDFFAAQNDTKGLLGCIEVLIGHSIQQYVADKEDPKSLETLEGFWSQIRELPYEPLENEEKFMVLKLMQLQADFYVQHDTKAACRRVLHEVLEKARSMLPIPPQHIIAEVYKKLTALSEEPAEQLANITAVEASLRQFKVDVESRIQNDQKAEIMAKIAGDIADTLCNKAFVQAEQGMIDEAETTLEDCSKLCEANSIENSRINCLSQIARGILCLKKGNKQGAEENFNKGIALAQAVNDEDVINQIQELVNDAKTKGGMPITKNETPAAATKPAAEAAAAPASAPAKKEKQVKAKTYPGAVKQKEKGFDITEYIPLAVFIAFLAIFFHLVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WSJ9</accession>
    <name>A0A6G0WSJ9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_012162</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000154">
        <property type="protein sequence ID" value="KAF0730462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WSJ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015928"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013256">
        <property type="entry name" value="Chromatin_SPT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22691:SF8">
        <property type="entry name" value="PROTEIN SPT2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22691">
        <property type="entry name" value="YEAST SPT2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08243">
        <property type="entry name" value="SPT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00784">
        <property type="entry name" value="SPT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="5">
        <location>
            <begin position="319"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="112"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="379"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="383"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0730462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="492" mass="56036" checksum="0797581945DCAE85" modified="2020-08-12" version="1">MSNKLHNVISESDWKTNRETARNLQKWLATLKTYKPDQNALRETRIGVAVSKLRKHDDNCVSAYASMLTGKWKSALDIKTAGSTSRGPENDRTMNIEAERKNEAARQRLQQSYANEKAKREARTSVFLDNPVAKRGKGRKSVSTTTITRYVNPPRPGVERKIPRAIAPPSTSKTISQVRPSSNINRSSSEHTKSYSSTSQPIKKMTPEEERHHRRQMQYRMLAEKKARETGKTVPASISKAVPAAKSTPAPASHSKPRSSSDKSERRPVKAAPTMNPKDKVDKEFLDKMYPRVAGRPPVETNTKQKRDEGSKAPAPLKEGEREVMHWLKGLTEDMSQYAQTFFDNGFDSMKLVSTINDKDIAAMIPKRGHCRVVEMAVQSLKQSRKSKPPPVAKRKRPSYDDDEYDSDDGFVVNDEEDHFVPGAITSMFRKGRGRRPAYYDDDGDSSDMEASFEEIQREEYRSARYGDYEDEVEDLRNRKHKEKKLKRKQKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WV25</accession>
    <name>A0A6G0WV25_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_011286</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000143">
        <property type="protein sequence ID" value="KAF0731383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020537"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="N1-like"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease/ribotoxin"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026312728" evidence="4">
        <location>
            <begin position="18"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0731383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="159" mass="17428" checksum="A41FA70F92659A20" modified="2020-08-12" version="1">MRFALALIACFISVATARKFKWVCQNTVIGRKEYEQNHAEASLHSANGVGRSGNSLSSYPHEFANHPGFRFPRAECNNLKAGQYLLEFPLFSDDIYNKQTPPTKRRVSKNPKKAPEKKPEPGPARVIYLAGSKTFCGVISHVGEGGRASGGGFALCARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WV27</accession>
    <name>A0A6G0WV27_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_011305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000143">
        <property type="protein sequence ID" value="KAF0731402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WV27"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005754"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0731402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="352" mass="40656" checksum="21A8F6B0148F2DC2" modified="2020-08-12" version="1">MTAVSQGHIEAIAKYYSEVGVNVSTNLTWFRQFVGHTTSIHWMGRELLPHVLVKWNDLRITWISTWVDFDGHFDNDFSYLNYLVVFRGHIMTPFRTEAILKYATSSSSLRHLYLRTSDRRYYGNRDCALTMSMANDLTQPVRALELHSFSWQDSNLRKEVMTAILACETIEKFGISEYDCADFSVTATFDRLTRQTHLDFYDFGSKRYHTVDVNHVHDFIHHFGLLFLETDELVLSRPHVTEFDVLWENLSPVLQQAPLEILKIEKFICTEDVANKIAEGLHGHPTVETFVLDEKCQVPYSGVVVLLSHAPATLKNLLIANDKADLTQLYADEDTKQLLQLAHERSINLFYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WVG4</accession>
    <name>A0A6G0WVG4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_011361</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000143">
        <property type="protein sequence ID" value="KAF0731460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006299"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="8">
        <location>
            <begin position="1210"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="298"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="298"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0731460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1625" mass="184588" checksum="4C6194332F982B9F" modified="2020-08-12" version="1">MDASNPAHQALPKTPTSAPNQSFDWSNEQQMALAFERFVQMNPHLLHQQSKVPLPTPTFNHFPHLYDEVMEAKTRQASAHFNKPFHPDEFKQLVSFDNIACPELTKPDLTEMKSFWKKYVRYRKELDEKYKIFDGSVAIQFKNVRQCMDEYTFESLCLYRWNRDPDDVSDEDVNCLFEADCLGSKVDIKIFLDKLEKDLKMDKSVTDGPSRVLCLVRLFDKICTESGFPKYYEIEVEASRRYFLNALEPISVRKKISTELRFSKKRYMVWKDFVDLCIDYMKTWCMYEDVFKSDTRPEAKPEARKKFDRPNQKPRVEKKQAESADTAAPGDAKAKASKPSYTCLKCQSVDHNVWKCPKLKDEAEAKSLLKAYYDAKRAAEPKKPNVDSLLSATGSDFIQAVCAGLEMKVLFDSGADVCVISRDFVRRATASGSTLHLKPLQAPVTALAFNGTPVVIRDGVKIDLSIPTNAGPIVMTNLRYLLVSKSVMRQLGFDQQTLLLNAQSIRPVWDFEPEYDPTTGQRLVGSLRVNAHDDLIHDGDEMCLPRPQPLDQQKIHVRNILDGKLEVAWQNGMDPVAHAKLTSLLTKFEDVFRIEIGRDPPVKVPPMVVKLKPGATPVKCGARRYSLNHREFMKTHMEELCEAGLMYRNDSSAWASPPYIVAKPGTNKYRMTVDVRSVNSRTEPVQWPMPVIEVVMENLAGSTCFVALDFFKGYWQFPLDPSCCDLYTIMTDLGICRLLSSHSDKYVQVTIIQVLLVWIDDLLVYAKTHSDLMNCFEEVLSICSETGLKLNPDKCEFFATELKWCGKLVSGSGVRHDPGRIAALQSMSLPRTGADLMQFLCAVNWMRSHIPRYNEVVAPLMAALQRVYSQSGLKTKKKLEKFVLPADFFSDAEKTNYDHIKEQLSSSVKLAHHDPSKMVCVFPDASLRFWGAIVTQVPMNQLSLSIDSQDHEPLAFLSGPFRGSQMAWSIIEKEAFSIVETCKRMDFLLLRPNGFKLYTDHRNLTFLYDPHSCSRDIARYTAEKVQRWGLVMMGFNYTIHHIDGEDNVWADLLSRWGAQHIPPSVQALHVIPSNPSPLLDEDFVWPSVDEIIALQDKALVEHPQLVEKDPTCPDVLTTHRPYCSSEGRMWIPSCDPGSNTITNIKIRIMVLGHCGTAGHRGLEMTLKAVSERFTWCDLIEDVKLFCSQCFHCQKSASGTMVPVPLGSQIHASRPNEVLHFDFLYMGPSDTGDMYVCILKDDHSMCLQGTNHPSADSDAACFALHSWFNWFGIVRTWISDQGSHFKNRCVAEMQRVYGAHHHFTLPGCPWANGSIEIVNKHFLKLVRCLLAEWKLPHTSWPRVTSIAIKILNHSPSRLLKGLAPITVFCNLPPCLPLNGICHPDTFTPIPPEEFDAFLASRYDGLEALQQSIYDMHSDLAAHKDKIRSQKRAQKNRGAVPQQFSIGDFVLVLKKSTSVPKTLYMWDGPWIITRTISNWTYEVQNFETKALLRRMLSFLILSSFCSVGNEVKKIVDARFNLVAKMYECQVVWLGMEDDTTWEPARHLYEDVFTLFKEFVLMKSSSTGEGHPEFALYKAMQIEFPLDGNAPTQHGKLKKSRKKGPSVRAIFAGKLPFKTQAGLLKRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WWC6</accession>
    <name>A0A6G0WWC6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_010965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000139">
        <property type="protein sequence ID" value="KAF0731866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WWC6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013951"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="2">
        <location>
            <begin position="25"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0731866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="271" mass="30673" checksum="54601691941185A3" modified="2020-08-12" version="1">MSQASPQPTTEERKGLMDKIRSAKRRFIQKALTKIGKAECSDDHEYQQLRDRQLELIDTVEHMLTHMKSFVTTLVSLGYGCTLLGEDMNVIRDNNAVKSPSYGVKPLNDCASNEFSQSMNRIDNAARELAASMLSTTVVANMQTKLDELHGFKKELEHRERLKLDYDSAVRKLRHAREHREAADVLRRDQKLQAAQAKLAESTALMVAKMKECEGTRGTMLQREVDDFRQMQAQFFQLCVSAFTGPPPPPRHAMSSKADEISQAEATNPFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WX27</accession>
    <name>A0A6G0WX27_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_010701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000137">
        <property type="protein sequence ID" value="KAF0732048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WX27"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015191"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0732048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="78" mass="8915" checksum="FDC9E16DEA14564A" modified="2020-08-12" version="1">MVNIFEPAETINYNFVSGVYAACSLIFVILLIAHQYTDQVEGFYIVFAPFVPCLLWSLVVRKNWLAKQAEAVKETKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WX55</accession>
    <name>A0A6G0WX55_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Acyltransferase</fullName>
            <ecNumber evidence="14">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ae201684_010727</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the diacylglycerol acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="14"/>
    <dbReference type="EMBL" id="VJMJ01000137">
        <property type="protein sequence ID" value="KAF0732074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WX55"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001048"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007130">
        <property type="entry name" value="DAGAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317:SF0">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03982">
        <property type="entry name" value="DAGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF0732074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="332" mass="37126" checksum="C23915B1680992EC" modified="2020-08-12" version="1">MVKMQAHPFKQITRGALGCILGLTLSIMGYIASFSTRLRRLCKQMGYWYISAAVIVAYLPIYLNGAETKVLPSQGGMQSDSFRQDRLWQLVASYLQLECIREAPLNPTERYVFGLHPNAISKFSGLAFCGGNFERLFPGISPRILLSSPLFYLPGIRELCLWLAGVDASADVADSVLDNGMSVVLYPGSLSEVLSTSTSSSEMELMLHQHLDFVKLAIRHGVSLVPTMIFGEKNLYRSWRVPQSMPDAMAWILRLPLLIARGRFGTWLPFLPEGKRKLGVVFGPPIAVQQMDDPSEDEIRQVHAIYVESLVTLFESYKGDFGYDHEARLVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WXN1</accession>
    <name>A0A6G0WXN1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_010625</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000135">
        <property type="protein sequence ID" value="KAF0732339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WXN1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001136"/>
    <dbReference type="OrthoDB" id="10262653at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.20">
        <property type="entry name" value="Ribosomal protein S26e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000892">
        <property type="entry name" value="Ribosomal_eS26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038551">
        <property type="entry name" value="Ribosomal_eS26_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12538">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12538:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01283">
        <property type="entry name" value="Ribosomal_S26e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0732339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="127" mass="14686" checksum="B5CFBB317F3DF38F" modified="2020-08-12" version="1">MAGVGLIFNGPHGHFTRKAVKMTVKRRNHGRNKKNRGHVKRVHCVSTAKLIPKDKAIKRFTVRNIVDASAMRDLKEASVYETYALPKIYIKNYYCIEAAIHQRIVRVRSTEGRRNRDPPARIRPKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WZ14</accession>
    <name>A0A6G0WZ14_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_010165</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000128">
        <property type="protein sequence ID" value="KAF0732836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WZ14"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001342"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45942">
        <property type="entry name" value="PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="25"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="171"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0732836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="197" mass="23244" checksum="A263B5C9A9CF332C" modified="2020-08-12" version="1">MDKDESGKIDFEEFVLSLWNFCSFTRESLVRYAFSLYDSDGSGDIDVDEAEHFVHEMWGDKWHSNKNAEAIMAKLRAIAKANDGYMPIENFVVFAHDHPLLMFPAFQIQHDMVEKILGEHFWTKIADQREKKQRTDKKFKTIEDILRSFNHNHAVLRQVKQVVSEAQSSRRMSFAESFRDKLNRPKNDKKRYKTHPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WZH1</accession>
    <name>A0A6G0WZH1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Centromere/kinetochore protein zw10 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_009849</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000126">
        <property type="protein sequence ID" value="KAF0733022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WZH1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001765"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990423">
        <property type="term" value="C:RZZ complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046362">
        <property type="entry name" value="Zw10/DSL1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048343">
        <property type="entry name" value="ZW10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055148">
        <property type="entry name" value="ZW10_C_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12205">
        <property type="entry name" value="CENTROMERE/KINETOCHORE PROTEIN ZW10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12205:SF0">
        <property type="entry name" value="CENTROMERE_KINETOCHORE PROTEIN ZW10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20666">
        <property type="entry name" value="ZW10_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22766">
        <property type="entry name" value="ZW10_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centromere/kinetochore protein zw10 C-terminal" evidence="2">
        <location>
            <begin position="410"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="ZW10 C-terminal helical" evidence="3">
        <location>
            <begin position="554"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0733022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="699" mass="78710" checksum="18D116B297341686" modified="2020-08-12" version="1">MSATTEALTQKLSDLHEEVAGLKCQIVEAVRVFYGSSANVSSSMSIEEAMQFASKWSQRGDIESDLQIRMKQLESILDETVSQLQPESAAEDNQIQQSIATKTRLHTQIQQSQEMLKLLRVLSELDTLFQSFDIHMDQLQYEDAAAKLASMESLVAENKAFPIMQLMHVQTSMRKNQLYCALDEQMDAVCFIQPNKMELFPLQALGAALQAAKRLQYHIDSAAASMNKHIVQPLLADASLIPQVHANTLSLLSKPNATEDGSFAKVLEHLLVVFKFVHAQWQMPGLGSVLWKSHLAEPLENLFLKNLPSTLGELPRFREQILPLMHGFDASMQTMEWAISASVFMESLERRYAQEKRQRVLVAVRTFMQKDYMDSVLVKVSTGGSSGGSSSGKKAKGKGISDDAETNELRVSLCTTKLLAQVESLLQEASTDSASPEVSALLFHTARDSLFLFRMGMPSMYKEALLQDPRVVMLLHNDCMYLTQNMLTCVYPLKAALPQGASMIDMVPEMRELGEFSLMHFAKTHTEKMIQSLQTCPTWSQVHEDAAFNQVETCIKVILFQFQRMLQHWKDGGLAPSVYATLLSRMLQPLVVQMIESLLKLSSSPQPIKAIHSVHHLFALWLDINTTFYASQTLAEKHISNWKKFQLLTQLMEDSLAGLQDKWQAGALREFSKQEMASIIKCFFTDSTQRQQVLEIVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WZI8</accession>
    <name>A0A6G0WZI8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_010087</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000127">
        <property type="protein sequence ID" value="KAF0732983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WZI8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013461"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0732983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="39098" checksum="F5E3B9984ACA4089" modified="2020-08-12" version="1">MAWTWSKCYMLIMIIANVIFLAAGIFVLYLGAYLKKEHWTDMFEGDELGNIEVLNGKVSIATVIFSCAMIVSALIGLFGAVFRLRSFLIIYSIISTITAIFFLVLSIVGFVVLAKVNSWKDDDFPADDKQEPKFATQFNKVYCYATGANICNNVAFDKALKTLSPDSPTDLISQVLDVLSGVLTSAGITGMQTLCENYMSGGPVADLLQLVPSFKLDPVCKGCELAGQFSRLNSVFAWANHECPPDPASLKWCVSFLAKKTVGEPYNGAPFGICRAKLYGALSKWSPVIAGPALAVSFLLFFLVFVACVAHRRDPKPSSDTAVEKEAATVKSGGQFVPINSKKVNIEPVKTPVVSPRQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X079</accession>
    <name>A0A6G0X079_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BRO1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_010012</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000126">
        <property type="protein sequence ID" value="KAF0733196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X079"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012807"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.560">
        <property type="entry name" value="alix/aip1 in complex with the ypdl late domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.50">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025304">
        <property type="entry name" value="ALIX_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030">
        <property type="entry name" value="PCD6 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030:SF30">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13949">
        <property type="entry name" value="ALIX_LYPXL_bnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="7">
        <location>
            <begin position="1"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="728"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="434"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="747"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="792"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="844"/>
            <end position="871"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0733196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="871" mass="95497" checksum="86A335C94186623C" modified="2020-08-12" version="1">MLAVQLKQTAAIDVTKPMRAYISKEYSEDEAKKFDPALASFAQMRNDVELVRTPSPISRQVLLRYVAQLDLIESRFPVGDTKVKIPFTWFDSFSPRQKLTQHSIKFEQAAVLFLVGALDSQSAVACDRSSPEGIKAACHYFSQSAGAFAAIQEMGLSGTTVDMCPEGLGMLVNLMLAQAQACFYEKAIKDKMKDGIKSKLATQAVAFYSSALEFCNSSTMKSSIDRLWSVHIQFQVLCMKAAAQFWQGKASKEVALTKGIGYGEEICRLSAADALCTQAITLATQSKLPPSLPASVRALQAIVVETLNIARKDNDTIYMETIPQLASLPTLTAASMVKPILPEKEKSIDLFEGLVPTWLRQKSADCEAICQSFVSASAAQVSAQNEAARVHLASLGLPASVEAFEKGTGVPPALWKRIESCQVQGLTAPISRILEENKRSKARVEEQLRTIENLLRDEAAEDQQARGAYGPAWTRPTSIALNEGFMADVDRYHKLLRDATQSDLAIQSSLNAPALALLGQNQSELEHRIPERDPSAAAVDTSLLNNLMVALGLLIQKRDELQKEMAAKATLPPSLAVLAASDESVFANKQAEVEQLKLQIEGTFAEQGDLLTDITERNEIFKHARQADPITRQREEAILELQKAVDLYEQLFSNATEGGTFYSELTQKLAQLEQTVVDHCAARELEKRELELNLQSAQDSALAQRLHETNLHDHQTQVQDQVASDAAFAAALASQDSKHPSAPPSQPQQQQQYGGYPAAAPAYAPSNQHPANPYAPNYGQSPQQPPPPPQYNHPQYNMYNAPPQYPPQYAQYPPQYPPPYGAPQQPQGYPQQPPPGYGQAPPGYGQPPPPAYTQPPPYNNSPYGYQPPPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X160</accession>
    <name>A0A6G0X160_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WRKY19-like zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_009777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000122">
        <property type="protein sequence ID" value="KAF0733543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X160"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017842"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056866">
        <property type="entry name" value="Znf_WRKY19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827:SF1">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24906">
        <property type="entry name" value="Zf_WRKY19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WRKY19-like zinc finger" evidence="1">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0733543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="201" mass="22284" checksum="56FF64968C339D90" modified="2020-08-12" version="1">MNEHVIPPCVIPRTRLLQPTGALYFDYQENINHATHFSIWHKMRKLSFDFILDQSGIQVDADEVSNIDEEEEKTSTKPSQHHCRHPGCTHWLVSRGACIRHGGGPRCVVPNCLSGAKTGGRCWKHGGSRHCTVADCPNLSKARGLCWAHGGGKPCKMEHCAKTALLRGLCWAHGGGKRCTVEGCKRPAYERNGNPCDRHAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X1B7</accession>
    <name>A0A6G0X1B7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="20">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">Ae201684_009527</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Membrane</location>
            <topology evidence="20">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="20"/>
    <dbReference type="EMBL" id="VJMJ01000121">
        <property type="protein sequence ID" value="KAF0733592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X1B7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003107"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02081">
        <property type="entry name" value="P-type_ATPase_Ca_PMCA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000014">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000033">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000036">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000029">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000045">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000144">
        <property type="entry name" value="copper-transporting ATPase 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022141">
        <property type="entry name" value="ATP_Ca_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF369">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12424">
        <property type="entry name" value="ATP_Ca_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 20" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 20" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="14" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-0187">Copper transport</keyword>
    <keyword evidence="18 20" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="19 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-1278">Translocase</keyword>
    <keyword evidence="7 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 20" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="315"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="351"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="790"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="824"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="867"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="905"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="943"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="975"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="21">
        <location>
            <begin position="25"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAF0733592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1049" mass="114738" checksum="F8CAB9149BDAEFB5" modified="2020-08-12" version="1">MSLSTKELSQLVESKKEHAAQALADYGGIEGVAARLNVSLEQGLDSNNSADLAQREATYGKNFIEAEKPLTILELMWQAFNDLTILVLTAAGTISLILGFIPLPKSSSSKSTGSDTETTWIEGASILFAVFIVTFVTAINDYQKEQQFRALNAVKEDEKIKVIRNGVPAEVSKFSLVVGDIVRVDLGDIIPADGIVFDESDLKLDESAMTGESILLKKDRKEAPFLLSGTKVMEGVGKMLVVAVGEHSQSGQITQLIAGKAVKHEEKVPDVNNSVTESTPLLAKPATQPEEAEDVEVVSPLQGKLDRLTMLIGSLGMYTAIFVFLAMVVRFSVVTFWIHKEPWSNEYLKEYLGHFILGVTVLVVAIPEGLPLAVTIALAFSVKKMLKDNNLVRHLGACETMGSATTICSDKTGTLTTNRMTVMECYLGNEEFDNAQSLRLRASDVTKDVLCTGICINSTAEILPPKQVGAKPEHTGNKTECALLQFAADLGVQYADVRKQTEITRMITFSSAKKRMSVVIPLGENKFRIYTKGASEIVLGLCTSVQNLDGSVTTFDDARKKTVNTTVIEKYAAQAYRTLCLAYRDVEATVDEIKDASQWSDDDIEKDLTCVAVVGIEDPVREEVPGAIRQCNYAGIVVRMVTGDNIATAKSIAMKCGILVPGDKSLVMEGAAFRKRVYDEQGNFLQDEFDKIWPKLRVLARSSPKDKHTLVSGLISSNLSTYGPQVVAVTGDGTNDAPALKKADVGFAMGICGTAVAKDASDIILMDDNFKSIVNAVKWGRNVYDSISKFLQFQLTVNLVAITIAIVGAVFLEESPLTAIQLLWVNLIMDTFASLALATDSPTQALLERKPYPRTKPLISERMTKHILGQGIFQLTILLTMTFVGDTILGIPSGRKDQRTSNDPTVHFTMIFNTFVFLQVFNEINSRRIHDEINVFDGIFSNTLYVGISVFQVVMQVLIVQFGSVAFGCHPLNQTQWFICIGLGALSLPLGLVLRLIPVPPSLAVDDAELPSTRGQELFLRGVKRVQTQIRVVNAFKRNVERRNSVLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X1G9</accession>
    <name>A0A6G0X1G9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_009488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000120">
        <property type="protein sequence ID" value="KAF0733643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X1G9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019483"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0733643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="195" mass="22321" checksum="4C61CC540A5B53C7" modified="2020-08-12" version="1">MTPRRGPPARQPAPKHPSQAIESRELVHSVRLDRDFLNPDRTLHFAHQVPSPSVPPKDILSTQRFEHEIKRIKELSPSLDSVELDSVERRSIMKHAPRPSKNEGRYDTSQLPDVEAPTPVKPRKVKKQVSEKWKQAHAVAPSIELNPLVDHGRETCIRTPLELTDDPSLFQWHPPSPVNSDNPPRYLNDNVLYFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X233</accession>
    <name>A0A6G0X233_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Defective in cullin neddylation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_009439</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000119">
        <property type="protein sequence ID" value="KAF0733881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X233"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001459"/>
    <dbReference type="OrthoDB" id="27198at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032182">
        <property type="term" value="F:ubiquitin-like protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000030">
        <property type="entry name" value="DCN1-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.200:FF:000003">
        <property type="entry name" value="DCN1-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.200">
        <property type="entry name" value="Cullin, PONY binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014764">
        <property type="entry name" value="DCN-prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042460">
        <property type="entry name" value="DCN1-like_PONY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005176">
        <property type="entry name" value="PONY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281:SF31">
        <property type="entry name" value="DCN1-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281">
        <property type="entry name" value="RP42 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03556">
        <property type="entry name" value="Cullin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51229">
        <property type="entry name" value="DCUN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DCUN1" evidence="3">
        <location>
            <begin position="57"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU410713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0733881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="249" mass="28290" checksum="16BE7A336FD7A161" modified="2020-08-12" version="1">MSSLTSKQEASVKELVDFTNCSRDVAITLLRKHQWKVSTAADAFFDENANLASLNTVNVDAINTWFDMYADPDEPDSILDEGIMKFCDDIGIDAQDTVVLVIAWKMKASVMCCFTRSEFVAGMRELGCENAASLRSKIDSIRTLIAEPASFKQFYLFCFGYSKEPGQKSLGKDVALAMWELILTPKFPKTADWCAFLQEHPAQGVTRDTWDLFYDFMVKVEQSYDAYDENEAWPVLIDDYMTYVVEKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X337</accession>
    <name>A0A6G0X337_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">14-3-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_009095</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 14-3-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000117">
        <property type="protein sequence ID" value="KAF0734234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X337"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007607"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08774">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000308">
        <property type="entry name" value="14-3-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18860">
        <property type="entry name" value="14-3-3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00305">
        <property type="entry name" value="1433ZETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00101">
        <property type="entry name" value="14_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026258289" description="14-3-3 domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="14-3-3" evidence="3">
        <location>
            <begin position="5"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0734234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="162" mass="18107" checksum="16C01CF4A7D83F82" modified="2020-08-12" version="1">MALDRGTLVFLVSLAAQAERFDESVGYMTTVVTDFEPILTDDERVLLAISFKNILDARRTASRSMRAMEATFDDKSVQHAVDYRLKIEAEAIAQCETLVRLLDTRLISHEPVESPSMIFYLKIRGDNYRYMAELQAGDARKASAAQALASYEKAFALASTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X3V7</accession>
    <name>A0A6G0X3V7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_008695</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000109">
        <property type="protein sequence ID" value="KAF0734616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X3V7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002836"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000849">
        <property type="entry name" value="Sugar_P_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43184">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER 16, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43184:SF12">
        <property type="entry name" value="SUGAR PHOSPHATE EXCHANGER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002808">
        <property type="entry name" value="Hexose_phosphate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="313"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="15"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0734616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="412" mass="43299" checksum="87CBFD815B521F68" modified="2020-08-12" version="1">MASPPTTTSWGYRLIFIFTYAAYIAVYFTRKPFSVTKSTLKTENVHTESELGMIDTGFLVAYAVGQFMSGPVASVLGSKLGLSFAFIGTGVCSWVFGTSPSREVRATAWLVNGLFQAFFFPFIMDVLRAWFPPSTRGQVLGVWTTCQQLGGFATSAFGGYVLSTSTWHDAFVWPAFLAFGFAGLCFTLLQASPSSGQTTVKTASTASSSRLWEVPHLLLVGSAYFCIKLVRYTFLGWLPFYLTSVLHYSAAESVLLSTAFDLAGTLGSVLCGYASDAWCGGRSARIVAPMCALCGVATLVYPHVAAVGSTPNIAIMAAVGLFVAGPDSMLGGAACAEICERAGVPSASTSATGIVNGMGSLGAIASGMLPILIKEQFGWNVLFYAMGGLAIVGGAVLLPMTSGKASVTKKDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X5P0</accession>
    <name>A0A6G0X5P0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_008201</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000100">
        <property type="protein sequence ID" value="KAF0735286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X5P0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003212"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18007">
        <property type="entry name" value="DEXHc_ATRX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044574">
        <property type="entry name" value="ARIP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45797:SF1">
        <property type="entry name" value="HELICASE ARIP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45797">
        <property type="entry name" value="RAD54-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="184"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="566"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="15"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0735286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1076" mass="121553" checksum="68959CF5DCCB8A82" modified="2020-08-12" version="1">MEVLADISDLLVDAIPEPQEDPLQDLINSSQQAMDQPEIHEEDHEEAGEASDHEQNATVVYEPEISQWSSEEDEEEEEEEVKKKLKSRKKRKLAEIIDEEDLEEDTLLARNQEKERAKMFTADDTPTNFGLTSDGCVCINPLPDGSIPNGSLGSPEAPVIVHPVISKALKPHQVKGVRFLWSHISAGPKGFGCILADYMGLGKTLQVITTVHTFLNVMTLDEDQSEVAKFNTALILAPAICVRNWESEFKKWLTPRELTRMRLMTLESDMSITERLNSIIDWNNNGGVMVMGYEMYRNIVLQATGEEKLKVKNQSFKSQLDDALACLCSPGPDLIVLDEGHRIRDAKSKLVKALSHVETKRRVILTGYPIQNHMKEYWTMVNFARPNFLGTLPEFKNRFIDPIENGQFEDSSESDIILSRKRTFILTKELSTLVLRRDAGYLHRQLPAKHEYVVLCKLSPLQVKIYKAFLREGVPKGSGNNKIDVLGGYHISLAIVNHPDVLHSTLPGKETTTSAPIQQNSEDVDSDVEAVEAVVRTMSHRLSFAEPLFPPNYQNGIAENSGKMVLLMHILRECRVIGDRTTVFSQSISTLNAIENMLSVYNVSKKSYEKIHAVRIDGSTSQQMRFQRIAQFNDPSEDVDVILISTRAGGEGVNLCGGNRVVIFDVCWNPCHDSQSMCRSYRFGQAKPVYVYRLISAGTMEKKVYDLQVKKEGVSKRVVDNTALERKFQKEDVKKYFDIHDFKAAQTQLLKTDSSSIDMGKPDSDQVLASVLSTRSSFLVDWFEQESMFEENTDERCSELEQKEALKENEMTKAARGIRLYQVMHENGSIKRTICPQCNFSNPVTDEDLEKKSLTCGECETPVDLSDPDRIVTVNNANHPEIAQMQAMQLMQARLREQMTQQMQQQQNALAAMQNQNPQVMMPHASYPRPMIPYDSSAMTPMAQRPLPTRMLPFASSQNGANNYPTVINLEDDDDSVVPVVAPPLPPAPQYKPRKILFLRKGLDRSMVEALKVKAKSLLKVDFDVELTNYTTDLVSAMPLERVLVWLQLPSLPSWVTLRPVQWLQDQVAAKDRMDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X6V4</accession>
    <name>A0A6G0X6V4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF985 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_007933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000094">
        <property type="protein sequence ID" value="KAF0735614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X6V4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002578"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06121">
        <property type="entry name" value="cupin_YML079wp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009327">
        <property type="entry name" value="Cupin_DUF985"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039935">
        <property type="entry name" value="YML079W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33387:SF3">
        <property type="entry name" value="DUF985 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33387">
        <property type="entry name" value="RMLC-LIKE JELLY ROLL FOLD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06172">
        <property type="entry name" value="Cupin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF985" evidence="1">
        <location>
            <begin position="4"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0735614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="176" mass="19930" checksum="AB81CE0F68BFAA0A" modified="2020-08-12" version="1">MDAQYFIKNLEMMPHPDAEGYISINHRSAIQVDTVGLAGPPKRSVCSTIQYLFQSLLFMHVNKASDTTHFWHAGRPIQYFLVNPATFELKTIILGPELHKGQVLQFTCLSGWWKAAEVVMNDDDQVDFGLLSESLGPAFEPGDNSFLEKDDVLRDAPHLLPTLERFLRPKDWARSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X7G5</accession>
    <name>A0A6G0X7G5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_007682</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000091">
        <property type="protein sequence ID" value="KAF0735932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X7G5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015637"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="4">
        <location>
            <begin position="4"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="173"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="173"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0735932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="208" mass="24206" checksum="A465FC78FADEC318" modified="2020-08-12" version="1">MPGRYVEVSDHHPGSASDVTIFMTRIDKHRLMVTKTEDDKKMVDIGEGSSAFPNLWATLQDKGYQGVDDAISSIRPTKKLKNASVTRQELERNNRVSSDRVLVENMFSQTCSLWKIAYATFTWSEEKYDLVQRLVWALTNFHTSLHHLRAQDKEFYSSVMARYISMAEERVEKKKRQRQASRDRRRVRLDLDRSSRDGSMGTQYSQGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X8D1</accession>
    <name>A0A6G0X8D1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_007216</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X8D1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012707"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
        <property type="entry name" value="FYVE_like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="5">
        <location>
            <begin position="269"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0736193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="356" mass="40102" checksum="41B15827A07D53F0" modified="2020-08-12" version="1">MKRPPSIFFSCPPLSPQEETRLRAVANETAVDVIAHSRLHGGPIHWTPHGTEANVKIFKGYDVRHHHRDAALETEIYLGLIEVKAHMEEIAAVFADQNGADAIDMAHLYTIEERTHRGTSVHVSWRGYKSFLPGVIRRRDVCLVDIADGFVTKDGRRGFVSAQRSVELPCCPELDPSLGYTRQVTLGSGLVALESSQRGTLYISYLLQLPGAYSGLAEHIVQAFKQDIVLKDKTARRRLLDALLPIRQRLFEAHLSRTPILNAMQLVPHEARYQCYLCLKPFGLFRRKTSCFKCGEVFCSKCTEPWRVQVGDRLRLVPICKFCVQAPSDVDVDDQLDQECSELEWAGASLETLVCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X996</accession>
    <name>A0A6G0X996_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SMP-30/Gluconolactonase/LRE-like region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_007114</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000088">
        <property type="protein sequence ID" value="KAF0736664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X996"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010793"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46388">
        <property type="entry name" value="NHL REPEAT-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46388:SF2">
        <property type="entry name" value="NHL REPEAT-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="NHL" evidence="2">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="421"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0736664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="464" mass="50011" checksum="48C64286DED5CCF6" modified="2020-08-12" version="1">MPQRTRRRPFTPEDETNTVCLLAGCGQRGCGDGRATSATFNSPSDICWLGDANGTLAVSDAQNNTLRIIAPGKEAKVHSLRSSTFNTPRGLAMMSSSPNKLLVCDAGHHRLQFANLPTTSLLTDMTFQVFAGCGQRGLRDGPAAVAAFNQPSDICVGDDNTIYVSDTGNHCIRQLCRVQGDQWIVSTIAGGMNQVPSKNVRGRLSMHSGYMDGPGSRALFRAPCGLALGSSGELLVADTFNHCIRAVAQSGEKNVWTVHTIAGTGGQSGHLDGACASALFNQPVGLCRTRDGSLFVSDKGNNCIRQIGGYVNPRKYCWVRTIDVGHLAPNWHFPKGIEPPFLLPRGLTELHHAWHTGTCEPSIGKLVVGVCDSGNHIVRVLTIDAPVEVTPEPRQVVSPAARSTKSTCPASPKAAKDVTTHPDIFKELKRLREENERLRRENAVFYQLVEAAADQVEIEELSHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X9E3</accession>
    <name>A0A6G0X9E3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_007563</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X9E3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019757"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="477"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="2">
        <location>
            <begin position="784"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0736553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="830" mass="92728" checksum="4A9A662FB7B0CA91" modified="2020-08-12" version="1">MFSFLTDIGVYTPTRVRMRGTDSVAYCQSSVQDMFADELYRCLLIWLDDLLGYSKTKEGLLAALERVLKICEFCGLKLNPKKCLFYQTGARWCGRNVSGDGVKHDPERIKALQDLKVLATGQGLQQFICAMNWMCTSIPRYNVVVGPLADLMERVYTLAGGRTRQKVSKIPLSEAGWDGSHVECLAACKKVLGQAVTLAHPKSDKLVCVFADASDLHWGGVVTQIPPEQADRELDALQHEPLMFLSGTFSGAAQRWAIVEKEAFSIPGGFALFTDHANLKCIFNPTSVNAAIPKYTATKLDRWALLLMRYDYTIYDIAGEANVWADLLSRWETNSPTICPIVHVPLKISPPRNEEFVWPSMAEIVDAQLRAVGEDAVPEVQLVGSHVLVAGEQFPVLKMASDAVWIPLSEGELQMRLCVVAHFGMSGHRGVNATRQILSDRFWWPHMGEDVAFFVGRCLHCAATGGHVLRPFGMAPHATKPSEILHWNFLYMENGYLHVAKDDFSQLKWFWETDVANAQVVARCLLQWFGVFGVCYHWVTDQGSHFKNAVIAELQHMLGAHHHFTTARCPWANGTVESAMKITLKTFRALYSECLMQPEQWRQIVPTVMLVLNQTPSETIGGIAPITAMTGSKPMSPLDLIPIPGSAEVVTLQELWDCRFQEWAALQDAVEKTHQEVLDASSSKRKRGRAARAKKKGVKMAEFDVGDYVLYMDVWGVSPSKLSVTWRGPAQVVKATSGWIFEIQNLITGIVREAHASRLKFYADESLNVDEELLSHVAHNADGHVVDHLVDCRFNPKTAAFEVLVSWRGLQEIENSWKPATKLLEDIPVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XB51</accession>
    <name>A0A6G0XB51_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_006510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XB51"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000979"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0737341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="254" mass="28700" checksum="1A2F7D0609A4C2A7" modified="2020-08-12" version="1">MMESMDEAFGSPQLNVLVISHIHSSIRQVNRLCDYIIRHEAVDVVFVCGNFVLPSPSTAGRTESMAAAEGDMTALLSRLEMIVCRVIYVPGPSDPSTAKRLHELKRAPRLTPYSINCDKVKISLTEDIEDNMISSSGDSDDKFHAMDLIVEGSKDERFAFEIRTVYHDSPDGRYNVYSKLSRLPWCCRIGLSAAKEGYMEWIEKGQLYLAPGWLEDGFFSLLTIAHRKDDENDGDEGYEVVRCRMERLADEFAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XB78</accession>
    <name>A0A6G0XB78_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Endonuclease V</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_006562</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XB78"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021763"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016891">
        <property type="term" value="F:RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06559">
        <property type="entry name" value="Endonuclease_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2170.10">
        <property type="entry name" value="archaeoglobus fulgidus dsm 4304 superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00801">
        <property type="entry name" value="Endonuclease_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007581">
        <property type="entry name" value="Endonuclease-V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28511">
        <property type="entry name" value="ENDONUCLEASE V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28511:SF1">
        <property type="entry name" value="ENDONUCLEASE V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04493">
        <property type="entry name" value="Endonuclease_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0737397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="27984" checksum="04D665EED9882C17" modified="2020-08-12" version="1">MNREAQEAAWATEQAEMKLRMDTSHEVDLNAVTLVGGVDISFFPNSDDACATLVVLTFPEIKVVCEASCHTRLTLPYIPTFLAFREIPALLPLFDMIPTDLRPQLVLVDGNGELHPRGFGIASHLGVMTLLPTIGVAKTFLNVDGLTKKSVRALVAAGKTATRTDADPTSTVALELRGDSSKVWGKALCTPGIENPIYVSIGNLISLDKAVEVVQRCSLYRVPEPIRQADLRSRAIIREWEKHGVDTSFKSCKLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XBC8</accession>
    <name>A0A6G0XBC8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_006609</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PGA52 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XBC8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015751"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01100">
        <property type="entry name" value="APPLE_Factor_XI_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000177">
        <property type="entry name" value="Apple"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018805">
        <property type="entry name" value="YJL171C/Tos1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018807">
        <property type="entry name" value="YJL171C/Tos1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31737">
        <property type="entry name" value="PROTEIN TOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31737:SF2">
        <property type="entry name" value="PROTEIN TOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14295">
        <property type="entry name" value="PAN_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10287">
        <property type="entry name" value="YJL171C_Tos1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10290">
        <property type="entry name" value="YJL171C_Tos1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00223">
        <property type="entry name" value="APPLE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026169279" description="glucan endo-1,3-beta-D-glucosidase" evidence="10">
        <location>
            <begin position="21"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="11">
        <location>
            <begin position="18"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="11">
        <location>
            <begin position="91"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0737447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="478" mass="50545" checksum="01A84516DA244772" modified="2020-08-12" version="1">MRSFLWLSLVAASVAADCSAIQDNTDYYGNDIANVVRPSAEYCCADCLANPNCVVAVWWDGVCYLKNKIGTKSSTTGARAVIPNRAAATSCPSIQENTDYYGNDIANVARPSADYCCADCLATTNCVAAVWWDGVCYLKNKIGAKSSLTGARAVIPTRTTQSTPAPASAPKDSLPVSKVRAGFTYPSNYRSGSYSMVTDLNGCQKRSVSSAGPIAPYHEDVTFVFRGPMDIYNIAIFQPASDGSWSRVSSYDRSSGASNLVFMNNANPQKYNGRSPQGYATSDGVGFTTSATKFGGRLNDGSNPSNIYGGPGVATGAEVNIMLPSVCTSNTCKGAFDPVYGLRGWSGSKIVVTKVKMDGGGLPAIWALNAQVVRANQYGCNCRGVGDPGGCGELDIAEAITKGSNTLATHNYWLNANPSTGHDTWTTRPTNGAATFVTIMDKASGVIKVLQLHGDDFASFNVNSISKQAMNQLIQVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XBK7</accession>
    <name>A0A6G0XBK7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MoaB/Mog domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_006514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XBK7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000975"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00885">
        <property type="entry name" value="cinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050101">
        <property type="entry name" value="CinA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056596">
        <property type="entry name" value="FLAD1_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13939">
        <property type="entry name" value="NICOTINAMIDE-NUCLEOTIDE AMIDOHYDROLASE PNCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13939:SF0">
        <property type="entry name" value="NMN AMIDOHYDROLASE-LIKE PROTEIN YFAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24102">
        <property type="entry name" value="FLAD1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="Molybdenum cofactor biosynthesis proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoaB/Mog" evidence="1">
        <location>
            <begin position="11"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0737345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="265" mass="29200" checksum="019A02F13B006240" modified="2020-08-12" version="1">MSSVAEPPKAAICVIANEVLSGKTLDTNSNHIAKFLFSRGIDLIRVSVIPDEMDVIVETVRKFSDLVGPSGYVFTTGGIGPTHDDITYEGIANAFNVPLELHEPTKQALEDLLTKSKRAIDLNQDILRMATFPKGCDILTTTTWVPIVKMHNVYVFPGIPNLMKQMLEANADHFKGIPIHQAIARTKQLEGLLAPALKAVAKEFPSVMIGSYVNHKEEGVSFKDRTYNVQVTLYSRVESDIREALPKVVAAIEGWVVEDVDAKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XBY9</accession>
    <name>A0A6G0XBY9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="11">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ae201684_006689</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 11">Belongs to the E3 ubiquitin-protein ligase UBR1-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="11"/>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015549"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071596">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the N-end rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd19673">
        <property type="entry name" value="UBR-box_UBR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.30:FF:000002">
        <property type="entry name" value="Putative e3 ubiquitin-protein ligase ubr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044046">
        <property type="entry name" value="E3_ligase_UBR-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039164">
        <property type="entry name" value="UBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497:SF24">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497">
        <property type="entry name" value="UBIQUITIN LIGASE E3 ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18995">
        <property type="entry name" value="PRT6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="13">
        <location>
            <begin position="89"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="1075"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="10">
        <location>
            <begin position="89"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF0737533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1492" mass="166920" checksum="AD60DBDF1CA065C5" modified="2020-08-12" version="1">MDIALPSLDGLETNQTTPRNVYRSLKYAVLDPLHRSALSAHLAANLLKMSDSGAHNLFKVLDYILTQRTMSLDAFLASRTQLYGSSNRTKCEEVWNGDHIAYRCRTCGLSDSSCMCVGCFDPAQHENHDYRIYRCSYGGCCDCGDDLAWKPSGFCSKHSTAASGASSLLPLPSDEAASVEVVVDTLLQCITGIIRRVYDEFTKPATIDFTHVIDKQRWKSSIPRSLSALSMASQTLVARLSLCLLQLQSLATSCLQYRAAICRQFLNPVSGVAVVAPRGADVLEFWLTFGVLLPTDSVDAIGVFFLKLLMDKDFKALFTVRFLDAYAFYIQLFKQADNSDGSHTRKHISRYIDRLFCQLFHSTAQLREMDTSAVLKTHAPLHGLPLTSNARLTLSEALTCYLVKQLGFVLATSASRSPTLRTNHPWIKTRVYARFCSELRCLLVHSDFSIQVIDTSWASAELDQESIYAELLRVLCSMQLMDMQVKQVGRHVEFGSDAWQAAFVLDYEIMLVWQHILNGFKQALTTAHDSKSLAQRWLDPISKQLEAWWQHVRLDPSPDTNVQRQVTYFARKDLVDRSASSMHLPLHHFWASMLDEAHRTESNEWLWTLVQSYDRSFWLRCTVHPILVQDFVRSIKCQEWIRNGQSMWHQVIHYHSRHWRYHGLHNDLFLMQLAAAALPPSVWMSVFLSQWLHHSQWENLNMIDEGLKAILQVVLDPTKIAALPPWELLMRNAIHCLSIGPLTRSEVAAKCDLRLVELVKSATGDDEEEIFSRLLNQVGVVASGVAADTSPFMVLRGADGNSGSAGTTTYILKPEAWSQVCPLFECFTAIDVQKCEQNALDHDKTIQLLPVLQYVRPAVQVSGSIHGLMVTHILACRNVLALVFWILHEHNEADGLVHTALYYLYISTSLLPSTQVMPPPFITPHDRLNAIAAAFGGTTWWDHLTVDVKIMTPPTSILALVRALVPRYPLAAKICDAIQATTATVDTKLPQPMPTNSCSKPPAPATLSAKERQAKILARLKAQQEAFLIAQLHKVPNALPLLDTTPSTIKDKEDVDDIEPLGSPPRLQDEEETMCSLCHEAKTNALHFMGFLTPTKIATKTQPAFSTKVECHIRICGHSVHQSCMEAYLVALRATHNEERLLSREHDEFLCPVCRRLCNTLVPLTLSTPNHGFADDSLDPNVVALATKVHQIVGDPSPPSRHTLVNLFAHCLYVATLSLQAIDIGEEHEIAERLDPTARRTLELLFTLLQPCTALQSSNLATKLIYAVLNPADENRGAETSRLLTKDSSTDEDGAQYALAQRQLHVLRFVVQSKEAITARLRDAFNVIEASNKFSLDSPVFQLIQLPKLYVDIYLKYCQRTATCEVCHQAPTHPALCLLCGTLVCCYAPCCSGGDGVGECTNHVRKCGVGFGVFLLLRACTVLLLLGHGRCCIWGSLYLDRNGEDDAYFRRGKPLYLNHERLATLTRLVVLHGFTESTALLNNTTRRDGTRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XCU3</accession>
    <name>A0A6G0XCU3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine hydrolase FSH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_005950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0737954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XCU3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017952"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0737954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="131" mass="14517" checksum="AB3C05907AC5DC4F" modified="2020-08-12" version="1">MAPFVHFVTIKIIGLSPKVTQTDAVSLFHRGATMDFDHVKQCAIFIHNSKLPVLCASARDDKLVEKAISDEICQVLQPVVKIEYKKGGHDIQKTRAEELAQSITAWTKSFVMDEAQPDDAKDSCKMSEIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XDM2</accession>
    <name>A0A6G0XDM2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_005837</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000077">
        <property type="protein sequence ID" value="KAF0738278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XDM2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018914"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05162">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWWP" evidence="2">
        <location>
            <begin position="7"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="DEK-C" evidence="3">
        <location>
            <begin position="239"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0738278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="298" mass="33807" checksum="D49AE1279443EAE3" modified="2020-08-12" version="1">MSNGSVANYVAWSRQDGSPWWPAYVCDPMKLRLDLYFLGTTHSILIEKAREFPKRYRLVYFFGTHKMALVEISRLVKKWKCSEHGAFTSGCPKKFFAKNIHLAEHLAESIEEAEDYLSQDPSTRTLPLMIPSDMDPSLTLPPRMGFVGIEDSDSTEDENNRDDKLTDKKIKPEPLPSPTKRALSPTRPCKSPPAPLKKPRRHIKPPETIDLTASSDLAIKTEDMAKQTKQVAASTVATTDFKTRLEEEVRLILASHSLESLTMHRLRSILSEKLAMDLKEHSETIRQIVICNMTKSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XDQ6</accession>
    <name>A0A6G0XDQ6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CBM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_005796</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000076">
        <property type="protein sequence ID" value="KAF0738360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XDQ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015369"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026114278" description="CBM1 domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="3">
        <location>
            <begin position="296"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="3">
        <location>
            <begin position="338"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0738360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="379" mass="41649" checksum="02AA42E92D0E60A9" modified="2020-08-12" version="1">MKWFYRSLLTLTALLLFCALVDAESPCKTVRVQGDATYCVFSTPCGRNSDQAGGLACPRRNDEAVADCVNGLQSYDNKTTICTAPEDATCNLLPSGEWGCVWESAATPNQLRGYWRQDYCADDYENCKGAEASSAPCCKSLSFICTPKNANTSICEPRRSNAEAPKWSNQGDFSGCLNHNQCEKGYYCRAYGIGGVFATCVSMYDNGGDPGGYGSLCTINGDCQNRFCSRNVRGTFAYCQPRRKGKYAVCKWDTECMEGKSCIANDLGTFSDCQPTPTDGGQPVESSVSWPTKKEIEVESWQQCGGVDYRGDKTCTPGNTCVKINEFYSQCQPDLNQPGLPTWSQCGGHGYNGETECRQEDKCKAWNSFYSQCVPRLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XEM8</accession>
    <name>A0A6G0XEM8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_005517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000071">
        <property type="protein sequence ID" value="KAF0738589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XEM8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012949"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="386"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0738589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="418" mass="46476" checksum="2EB055B2B5F12154" modified="2020-08-12" version="1">MTRETHADPTSAEAAYQRRQPKSKGEGRRLTDKLRLEILAIVDAKAGFTNGEIGGRYDISEAAVRRLKRNRAHVLRRYALGHEKVRDLRCRGVKADAPFNEEICQYIMDHPDASSSWEIRRKARLIAPRYNKHEFFASYGWYTHFAKQYDIPKLRELGLAKRKADEEQGQKTIAANDEQSGKKSLPKRLRVQFKVESESESELDDSPPTKRAKDFDTTSTADATAATEVEESANEASNEEQVDGTPAEGQESEAASATEDDEDDEEVDETPLDVQQAMAATEDAESDDESSLEEVDETPLELQVAADETAATEDESSLDEEVDETPLEVLQSTAAARGNESPQDLESDDLDGEDEETQMPHEARRTAEASPSFEDNESDDDDEAIWAEQTAAAARARLSSDDNDSSSDEQSDVEMNDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XFX9</accession>
    <name>A0A6G0XFX9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_005250</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000067">
        <property type="protein sequence ID" value="KAF0739069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XFX9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013350"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050222">
        <property type="entry name" value="MATE_MdtK"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43298:SF2">
        <property type="entry name" value="FMN_FAD EXPORTER YEEO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43298">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN NORM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="352"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="395"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="530"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0739069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="552" mass="60198" checksum="23DD49B871351871" modified="2020-08-12" version="1">MDEEASLLPKKWKLGQDEDGIEMYGAVDSAEVVPESMDLIPVGQEIQELTSMAIQLSLRQMVRQAMTLTDAAFQGHVGTKQLAGVALASMWMGVPSAFIQYSIQAIPTLCGQAYGAKNNILVGIWLQTAIVFATVACIPVMVYYLFVGKLIALTMGDAETVAYGQTFAQVMALGLIPQYVYNACASYFAAQGVIMPATLCSGFTMLLNIIFNQVFIYGAWGWKGFGFVGSPLATVTSTYLQLFLFLLYAVGWKKLHVHYWGGWTWDCIKRERIQLFLTLAVPMGMSSVVDWSSAAVASAFSGFLGPQIAAAMSVLNGIYGVANATVSGFSISTQIRMSRYLGQGSPTAAKRVLMLGAQIVMASASVLIAFVVWGRHALFHVWTDDPTILELCSEGLFFFVVCVMVAFGRFLLTASMNALSMADVNLFANNIASWCIYVPLSYVLPITLQWSINGFWVADTFGETFKVIVLAWGLARVDWVARAEQAQTAAETADMLRPEQEEARELAAFETEALTPGSVRSPSLLLSTKSHHTPTQMHQAASMTPRQSSKLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XGP1</accession>
    <name>A0A6G0XGP1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_004954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000064">
        <property type="protein sequence ID" value="KAF0739385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XGP1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016163"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0739385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="503" mass="55992" checksum="7AD52B59033B57B2" modified="2020-08-12" version="1">MERDNDAGFSLLNEKEVADAKEYTPEKWTWQRRPKSIWRKLWRKRVLVVVSLVVLTLVGCLVLVILVLKLKDTNVSLVKLHLPDLCNKTSIGMASLQFDNPSFCEPFIGPIFLTVDANSTDRLMDISINSFPLASGKTDITSLVTFSIVANASTLQRILFESPSPQINLAGKIPVHLGCLLVPFTVTLDAQDLIKPSATMLTSSWTANDFDIATRVREMIQSILKSIALSEGHIEQDREGVYLFTDVTFTYSSNVQWTLPDLTFRLAEKNSTLLTAGLYGFPLGSGVTHLDSFAYLRHNDSTPLLDAVTTYLKGQDVYLQVIGDDTLSRCFAQRLWNDMHFPVDIPATVDGKPAFLRHYALDPTLKKLDSTTRTCELRLDVALTIHNPLPFELILRSLEFELLYANATEPKASAHVVASAIDSTVVDWKSHMVNDVNFGLVVTDFDVCEDLLVLYLSDALEFSIHKGSLALGLGQGKTFTIPFEVDGIRIHPPPDNSNLDSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XGR5</accession>
    <name>A0A6G0XGR5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ammonium transporter AmtB-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_005002</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000064">
        <property type="protein sequence ID" value="KAF0739436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XGR5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017056"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097272">
        <property type="term" value="P:ammonium homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11730">
        <property type="entry name" value="AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11730:SF58">
        <property type="entry name" value="AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="6">
        <location>
            <begin position="115"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0739436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="481" mass="51546" checksum="B086DFA29D8482E6" modified="2020-08-12" version="1">MATIVSIDGADVHEVLFQLAEAAYRSQKESMQALAFHWTLCLTFLFHFGALIRRVEPKLQPPRISTTNIGPQLNYCHSNQPKAPPVLLGYLGGSIAFGFVAAVYCAIVQPTKAAQMCLSYWAYSLTVTSILSSAAQGRTFNGIPSWCLVIMVSGITYPVVVWSVWLDGWFNPRSAQAIFGIGATDFGGSGALHVVAGTIVFVAALCGTPTGTNMSSGHATRPSMDAAGTVWLVLGLCGVLLNRVWISVPPTYQFPATINCVVNITLAGAGGSVVGLAQDFFISGVTQDTHNCIVSAVVAVSSVGPLAEPYAACIVGVTAALIYCLTTWSTWIQDVDRPLGYCITVHLIMGAWGVLASGVVGTRQGHWQVYSQADTCGLAYGCSDRGTLFASNLLYLVCLIVWTALITYGAISIIRSLDPTTHYDVLGTIDFAIGDYEASDIRFYSADHSKRESSSEWASMSPLLDELIQYQKSTSPRTSWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XI32</accession>
    <name>A0A6G0XI32_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_004516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000056">
        <property type="protein sequence ID" value="KAF0739933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XI32"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015027"/>
    <dbReference type="OrthoDB" id="442921at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000202">
        <property type="entry name" value="Small ubiquitin-related modifier I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022617">
        <property type="entry name" value="Rad60/SUMO-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10562">
        <property type="entry name" value="SMALL UBIQUITIN-RELATED MODIFIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11976">
        <property type="entry name" value="Rad60-SLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="18"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0739933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="96" mass="10737" checksum="D79D9F31221DE8BA" modified="2020-08-12" version="1">MSDNEDNKGADDEKKQTITIRVKDQSGEETFFKVKPHTKMEKIFSAYAQRKGVPVTALRFLLDGTRIGGDQTPKMLELEDQDQIDCALEQVGGASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XI34</accession>
    <name>A0A6G0XI34_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb/SANT-like DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_004690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000062">
        <property type="protein sequence ID" value="KAF0739804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XI34"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007144"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044822">
        <property type="entry name" value="Myb_DNA-bind_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33324">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33324:SF2">
        <property type="entry name" value="MYB_SANT-LIKE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13837">
        <property type="entry name" value="Myb_DNA-bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="2">
        <location>
            <begin position="68"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0739804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="128" mass="14582" checksum="07BBA5D4D6E58528" modified="2020-08-12" version="1">MMTTNTKRNGIAWDSDAPNEESVSSLDVLLECLTEDNNYVRWRAGSQKKVSSGHVAHSTGTRSLPLTTSKEKVYHEIVKNLHAKGLHHRSSREVRSKINDLERTYRSARDWTNSTGEGIRDEDEELEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XKD2</accession>
    <name>A0A6G0XKD2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U2A'/phosphoprotein 32 family A C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_004017</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000048">
        <property type="protein sequence ID" value="KAF0740643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XKD2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009218"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454:SF56">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="339"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="413"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="567"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="634"/>
            <end position="881"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0740643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="887" mass="102072" checksum="1995309ACF3558AA" modified="2020-08-12" version="1">MSQASHVNQHIFSIDDIEIEDEASVETLNLHGNCIRTMDGLQRFRQLKELSLSSNWIECPSFVALKGLTHLTVLNLSANRMTTTIGFPILPSLRELSIAYNSLNSLEGLLDPIKFPKLEILDLRDNEIADLAALSSLFYLENIQVLRLQNINKSQANPVCSTQGYPSRLLERMSTLKTLDGEDVDVLRELASLSMPKYTSVAKLFRPASAGNRPPQPAPEWTALDARLRVLESQTQDAADTTSLLGDIDSKIQTATQNLHKMHKQTLQRSMLEDDDLDDDEIEVVSNTKLHSNGRSDASTVACQCDSVTTRETSTQSMDVLASSKAIQCDIADDFIPRIEAAEERARRAEAELVKLNLERSNTIKERETLTRELEALRLERDRFQQDSIAKNQEYKAAMEAQRKEWDGAKDLLLKSQSRVESLQSQLKEAHEKIKSQATAMESTAALAKEQADAKIREQTQSSQEKLDEAAAQIRQLKRDAQELKYSLEDSHAKYAINEKELSLLRHDGLVKSSEMDKLVFQHKEEIQRREKEFKQQTMLIDRQFKMTLHEMELEFRAKQTESILKIKQLHQAMHRVTNDCRQWEAKYEAARQREASLANRVQELTGKLSGVDKKLKQIESACQRSMHDRDTAIRDLEAQLDKAHAHAVDLEGELRESHERLAEMEEAAQKAKEVASTLQVKNIMLDDQAKQLMALRRDLEVERQRREDLENHLRDMEHALDESLARQADMEADARRIEASKDKLDQWDHLQEELENKIQALEYIEKEMQRMRRTIAKQEESATERAERMRHEHDDAIRALQDAMQVQQQQLKQSETKCATMEAKYQEAMDQNRILQRSVRDHATRVRTTENEMKVLLVQMEKERQAKRQHMTKISQLLQQLNHENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XKM0</accession>
    <name>A0A6G0XKM0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_003754</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000042">
        <property type="protein sequence ID" value="KAF0740864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XKM0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000249"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15841">
        <property type="entry name" value="SNARE_Qc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051707">
        <property type="entry name" value="PI-Interact_SigTrans_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336">
        <property type="entry name" value="TANDEM PH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="10"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="228"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="144"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="228"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0740864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="333" mass="37144" checksum="8263362D346A8F36" modified="2020-08-12" version="1">MQMDLSKIHQTSCEGYVTKRGHLLKSWKRRYMVLDGETLHVSYYDSKEIYQSKGEPKGSFVLTECEKQDLSDEGSHVKPFGFKFVGHCPGRGYKEFSVFVETQIDQTKWLNVAHNALGKSSSPQKTINQRIEEITGHKEASGLMLSMEAQMKNAKKTSKELLEQAIKDAKEADRIGKATVGEMEYQEEVLNEAEGTLDVASGQLEHAKEVGKELKHPILYKLTHLFSPKKKKKKGKGGHGKGGMKQPSGVSRTPKTSPVKLQPAGLPQKQEEDQLDELSKILANLGKTAETISVITDRTAEQVDRIDHKVAILDDQLKKEVKVVSEVLKSEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XKM6</accession>
    <name>A0A6G0XKM6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable pectate lyase F</fullName>
            <ecNumber evidence="4">4.2.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_003932</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Eliminative cleavage of (1-&gt;4)-alpha-D-galacturonan to give oligosaccharides with 4-deoxy-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.</text>
            <dbReference type="EC" id="4.2.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.2" evidence="4"/>
    <dbReference type="EMBL" id="VJMJ01000047">
        <property type="protein sequence ID" value="KAF0740698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XKM6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010113"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004898">
        <property type="entry name" value="Pectate_lyase_PlyH/PlyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33407">
        <property type="entry name" value="PECTATE LYASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33407:SF9">
        <property type="entry name" value="PECTATE LYASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="domain" description="WW" evidence="12">
        <location>
            <begin position="404"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="12">
        <location>
            <begin position="488"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="12">
        <location>
            <begin position="577"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="12">
        <location>
            <begin position="671"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="12">
        <location>
            <begin position="759"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="12">
        <location>
            <begin position="858"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="48"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="86"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="205"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="54"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0740698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="883" mass="103494" checksum="C443C0D200069E43" modified="2020-08-12" version="1">MGKLTTVEKTSTIECRKCKTACPVNFKFCDQCGQKLHRVKLKKPKKLKSMIPDYPERLPESTNAKSDETTPKSWYWGSQALPRLNGKLKKPTCDNPSHKNQQDPSDEELKSTNKSRKRSRDTSFSLPLLKPPVSSEVPRQNIMWGQCLDKAEAEYIAKEALLAAEISANSKILVHMEAQAQAHAFENDDVFKFACETKRKVERALKVDKDALKDVRKQLERLRGNKSNLSVLETKIQRMREEEERQRALKLKATSKIQAWYRRQRQRRLRQSMLCIKVCRGYLRYRYDKRKHELFPGDFYFVQDRKMRLSGTSQLEFVGNASKREYKHPYAFHLSNHEVKTILKAVSRLQQFFRSRMSKWYRALQKAQQQVIQRARQEAMLHEQCAVRIQVLFRKRQARLRLQQLVQSTFEECVDPTTNMVFYYNRKTQQSQWAKPKWWRTTTSSAPQLVKVRHINFTELETPRRLTIAASIIQGLFRKRQARRRLKQIIAETYKKVFDPETNMFFYYNEKTGMSQWAKPTLLGSDDIQAAPRPSKTAQVEMKDVFRGLSTPRRLELAATKLQGMFRSRLARRRLRDLIAQTYQKVFDAESKMSYYYNTKTGESHWTKPMLLGSSDIEEIPVINSPVCKGATPLIELNTPRRIELAAFRIQGLFRSRNARRRLRLLIAQTYQKVLDPESREYYYYNIKTGESQWNKPKLLGVSDIDSSPGTAKTPRPQANRLATLETPRRFEAAAIRLQCLFRARNARRRLRHLIAQTFQKVLDADSQQYYYYNTKTGESQWTKPVLLGDDDVDKPARHHRKKNPRAFLSGLDEAQQLIAAARKIQGLFRMRNAWRCLRTLIAETVKKYVDEDSHTCYYYNVRTGESSWTKPRLLGESDLDET</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XKT7</accession>
    <name>A0A6G0XKT7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_003892</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000045">
        <property type="protein sequence ID" value="KAF0740761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XKT7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011822"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF466">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="43"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="115"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="161"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="223"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0740761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="324" mass="34947" checksum="DF32B0CE062BC755" modified="2020-08-12" version="1">MKMVVKCFGGYGSFGEMEQFEENDDEIVEIGAGHTTTFAATSKALLGWGTAFHGELQSSSISRWSLSVCTCLWWGEQFNRQSQQPEEIKFPTPRKVQATQVAAGENHTLVLDSSGVVYSWGSNAYGQCGNNNDGDVSVVDAPKAKYIAAGANHSAIISNDGSLYTFGWGLYHQLGGGSTENVAKPTCVTCLEGVGELLGTKKFSGLAEVACGAWHTAALTTTGDVYTWGWGQHGQLGHETLESQVFPKLLDIDWEVVNISCGTRHTTILTRDGEVHRWGFSCPNDQIVAGKSSESNKTHCQITSHAMRIASGSYHDVIVQTTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XLM7</accession>
    <name>A0A6G0XLM7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_003731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000041">
        <property type="protein sequence ID" value="KAF0741170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004234"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006560"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011171"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="425"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0741170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1282" mass="146459" checksum="04B2C40C3B2C01B1" modified="2020-08-12" version="1">MPGFANLKPLWDKRVQDRYLVIHTTWNSTPVYFHNVYAPVEDDQRAAFFESLPVDFGDDDTGIHIVGGDFNLPMTTSLDATTPPSNYNAGKAECLAWLAALRVTDAWRLMYPSKPAHSGPRRKNRLDYIFVDRALATFHLHTTTYDANRFHGDHLTHTVTLMASPSTSQSQPSSKLWRLPRELLLDHRTVKAIQHEAQSLLDELLDQPDCNAGAKWSGWLRRMKRKMRQGQFNRLRHRQEVLTFLRRRLVNTKSDAKAGLADATTVDAVREIYTAAKKESHQASMDSGFDSHANLNESPTAYFLRKPPATKVPITSALLNGEIVTDPADVAKAFTAHWSSIMVEPSQAPPPDPTTREAVLDHLQTALSADQRDELDRPLTADELCSAIKSMRKNKSPGLDGWPAAFFQTAPEKFAAILVIVYEYQRKTHGLLLPHKRKSSITLLYKKGERADPGNYRPIALMPVEVKILSRVLARRLSSVAHILVHPTQSGFIKGRSMNDHIHLIQTLQHRATRTNEEWYATFLDFAEAYDMVRWSFLFEVLERMNIWPEFRDWVQLLYKKTQVHLLLNGALGPPIRPPRGVKQGCPLSCILFDLYLEPLGAMLRAYPEAGILLDNDNTLTSIFFADDSTLLSGSLESAEFQVDEIVGQFCAVSGAALNKAKCITLALNDNEEPLGRPSAPSITLSKSGEPIRFLGAYVGHRLDPLYHVHHINDKYLAAFSQWSCRARTIQGRRALATSMILGLIWHVTSVTPIPNGILLQWQKKLTKFIIGGHSSVDSSFRSPINKEWLFDKRLGLGIPHIASIIHGQRLRLLQRFIYESNTSPPPPWTTLVANQFANCTRSIHSPNRPYDFLWYSPQHSSAWLNLAELHPLWQDVWKSWSSVPTKYKFPLRPDFPTMLHMPFWLTSYNEFLHNGSVTPASLVSRSTEARLWCQHGVTNDVRCLYDILHLSTPRGRWPDFQQFLGLMSSGNPFCTVSLQHDGIWFSPVPRARGLYDHLTNVYHSVCARCQEDPLLHNIDKDPQPHAFRALVRDRIQPFEFWPRKLVARMAFQGPIPTSPHPTSTPQRHNHDKARSYMSLVRKSLQWITPVHADVWLRAILKMLPVNDRFKYYLPGEPERRLSPHNCGTNETIAHTLHECPSIAPIWAAHSPPWRQYGVSFSWSLSSNLDAFKVKTSARSLKDVLFQLWVMLTGVTLHMAWTQRNHRKHRHRHAPPHHVLVEESFIAWTSTIRWWMRRQDANDPILLEAKMALDKLLSIPPYFELRRKYPRCLSTETTFDVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XMK4</accession>
    <name>A0A6G0XMK4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_003325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000036">
        <property type="protein sequence ID" value="KAF0741650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XMK4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017640"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0741650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="225" mass="24904" checksum="399D9727AD0566DF" modified="2020-08-12" version="1">MNALNYDDLAMHFDQDADEVDPYVVCEGVSVDVFNKYVDEEDESLRVRLPFLDLSDDGRFLIVDLATRVHESTKCEFGTEFVFASGNRREIGQGGSMTVSKTALPNKAADATYGPLRDTLNRTSPPPPRTVSDWVTLAVEYVLLLKVNANATELEYRLYDIVVPGPLPNAPTANGTVRRNEVPNPGDIVSFDMRRVLSIPADQALPEDVNDVANVNLRAVLNNVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XN35</accession>
    <name>A0A6G0XN35_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_003074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000034">
        <property type="protein sequence ID" value="KAF0741884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XN35"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012587"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="1">
        <location>
            <begin position="35"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0741884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="165" mass="19679" checksum="9601D0F0E93F5BA3" modified="2020-08-12" version="1">MVDERWSPQEEQHEVQNAMLAATRQCFIEIDKEEWKFETLCDLYEAVTITKGVVYCNTRERVEWVSEHMRAKGQTVSTVHGEMEEAERAMSFAVALQIARVLINYDMPTQVESYIDRFAPYYRFGRRDIMVNFVLPSEMSMLRQIEQFYHTEIPELPMNVDEFFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XNN8</accession>
    <name>A0A6G0XNN8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_003032</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000034">
        <property type="protein sequence ID" value="KAF0741840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XNN8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000845"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0741840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="174" mass="19498" checksum="10F5A7AD4C02451B" modified="2020-08-12" version="1">MTRHVTVLTNAVGLEDGRTITKRIQTNEVHLGGKDHVNDRRDDLSNQIEVKIEDNDLHDAKTTDAMLDLIARRIPRNGLKVTEIATINVATLREIVQGVDHQEDRTICAEKGVARGNDHLNDINTTMSHHGTEVQVLDDVKLLLVREIKQVLLANRNLHGIEMKQALLDDVTQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XQF3</accession>
    <name>A0A6G0XQF3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RWP-RK domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_002622</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Putative transcription factor.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000027">
        <property type="protein sequence ID" value="KAF0742530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XQF3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007298"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044607">
        <property type="entry name" value="RKD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003035">
        <property type="entry name" value="RWP-RK_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46373">
        <property type="entry name" value="PROTEIN RKD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46373:SF2">
        <property type="entry name" value="RWP-RK DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02042">
        <property type="entry name" value="RWP-RK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51519">
        <property type="entry name" value="RWP_RK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RWP-RK" evidence="7">
        <location>
            <begin position="40"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0742530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="332" mass="37763" checksum="7FAADF66680B6984" modified="2020-08-12" version="1">MDRLMTSSPLQQPQDGRHHLENVVDSTACLGHLSDDDELRRVTPLQTKKAMILQSPVCNFEAFSHFFHLPLKAAAEKFGVRATAFKKRCRSIGIRHWPYRKVRSLKRSLQELNRCKDNGLLNDKQHYQYETFKKQLDKLMSPETYGIDPSGQLLHAFMDDDDDMDSGDDMCSMDSPRYGGASFSDCSISPTDVEKAAFPDHFGSFDKQQLPPLRKPSNIYLPRTMNMASDMPALTLRMTAKDMANLPPISGSVSLESYFDRPLQSNTQTSLEVDPEDYMDDHTQNPTPLGDDIMLADIKYDDDDTFDSSEYHGDRFFDDVFLQISPDYGCLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XQG0</accession>
    <name>A0A6G0XQG0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_002615</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the histone H2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000027">
        <property type="protein sequence ID" value="KAF0742522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XQG0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012321"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000005">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="10">
        <location>
            <begin position="25"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="11">
        <location>
            <begin position="107"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0742522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="143" mass="15046" checksum="89C3F7F6408DD524" modified="2020-08-12" version="1">MSGIPVGGKGGKGGKGGKGGKGVSSKKAPQSRSSRAGLQFPVGRIHRFLKKRVANNQRIGATAAVYTAAIMEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEELDSLIKATIAGGGVIPYIHKTLVGKVQPLIKKKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XQI5</accession>
    <name>A0A6G0XQI5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_002468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000026">
        <property type="protein sequence ID" value="KAF0742566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XQI5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012213"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06910">
        <property type="entry name" value="MEA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0742566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="166" mass="18494" checksum="07343D3DDF8A0835" modified="2020-08-12" version="1">MSSGVSALDALEREYEAVLRQKPIVPVSLDAVRQRSALDGADGEEGQEFDEMQSICSYAATCDDELERERANEEDDEDGEDYEYEPLQDDDEDDWDKEVSEIAAADPPVIVKPINLSDNDKDAIKRAMQEITLPAPSWGKNVTDDQLVEMVQDATISTVKDEPLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XR74</accession>
    <name>A0A6G0XR74_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphoglycerate mutase</fullName>
            <ecNumber evidence="8">5.4.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_002252</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.11" evidence="8"/>
    <dbReference type="EMBL" id="VJMJ01000023">
        <property type="protein sequence ID" value="KAF0742855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XR74"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004301"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004619">
        <property type="term" value="F:phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000003">
        <property type="entry name" value="2,3-bisphosphoglycerate-dependent phosphoglycerate mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01039">
        <property type="entry name" value="PGAM_GpmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005952">
        <property type="entry name" value="Phosphogly_mut1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01258">
        <property type="entry name" value="pgm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010713">
        <property type="entry name" value="PRK14115.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11931">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="5">
        <location>
            <position position="31"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="30"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="43"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="109"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="136"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="205"/>
            <end position="206"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0742855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="277" mass="31502" checksum="329F20C02FAF03BF" modified="2020-08-12" version="1">MLFRALARAPRNASSWTQASRNKHTLVLMRHGESEWNKTNQFTGWYDAPLSAKGHEEAQAAGRSIAEAGLTFDVAYTSYLRRAIRTCWHVLEQSNQMFVPVHNEWRLNERHYGGLTGLDKAETVKKHGKEQVLIWRRSYDIPPPQLTTDSEYYPGHDRRYKDLKKEDLPLSESLEMTAARVMPVWEQEIAPSIRAGKNVLIAAHGNSLRALVMKLDNISKDEITELNIPTGVPLVYHLDDNLKPIPHADAIAPLSAFYLGNQEEIRARILGVKNQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XR95</accession>
    <name>A0A6G0XR95_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_002247</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000023">
        <property type="protein sequence ID" value="KAF0742850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XR95"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0742850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="89" mass="10016" checksum="1B955B7087B90DFB" modified="2020-08-12" version="1">MCTRPWRTDLQTGQRRISIATVVIMHWVHQDTLRFSIFPVGFASSIDPSSPFSFMYTIFLSYIVAGARENEGTNLPAACRFTSLPRGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XRF2</accession>
    <name>A0A6G0XRF2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_002107</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carotenoid/retinoid oxidoreductase family. CrtISO subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000022">
        <property type="protein sequence ID" value="KAF0743048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XRF2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003671"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052206">
        <property type="entry name" value="Retinol_saturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46091:SF3">
        <property type="entry name" value="AMINE OXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46091">
        <property type="entry name" value="BLR7054 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="8">
        <location>
            <begin position="77"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0743048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="593" mass="65428" checksum="C18729D2A817AAFE" modified="2020-08-12" version="1">MEFYTQGSSLYATATAVAVVAASWLALYGKQNEPHRLTLSSSRVDLYKIPDDDLIKKGFAAKKVPEDIDVIIIGSGMSGLAAAVALAKEGKRVLVLEQHDVAGGNTHTFQEKGYKFDTGFHYIGGKLDDKKLSNRKLFDYLSDQRLEFQRLGDIVDVAVVEGEDGVRDEVPFLADMATFKEYLKKRFPDEHKAIDAFFDTVNVANRSIGAYFGLQMCPTWARGIYRWLNASKLKYMQKTTMEVVSSFTKNKELMGIFNYSWGDIGEPPTRAAFYINAAILSHYRGGAYYVIGGASVITKKIVRTIEEYGGKVLVRAPVSSILIDQSGTGVGVLVKGKQIFAKSVISTIGAPQTYNKLVPEAHCHRVATQIKELANPSLQPCCSAMSLFIGFKGDAKELALPTHNIWKFPSWEHDANFEAAKKSPDAPFSALFMSFSSAKDPTYASRCPGKQNGLVVAASFFEHVEKFKDGRVKHRGAEYEAMKEAWKERMLDAFLKEFPKISRDSIEVAELGTALTNDYYLGTHRGAIYGLGHTPARYASDVVNPRTPIANLFLSGQDALNCGIVAATYSGFMTAAIVEPRVQLKLEKILARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XRP9</accession>
    <name>A0A6G0XRP9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_002080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000022">
        <property type="protein sequence ID" value="KAF0743020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XRP9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016027"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051253">
        <property type="entry name" value="11-beta-HSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44279">
        <property type="entry name" value="HYDROXYSTEROID (11-BETA) DEHYDROGENASE 1-LIKE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44279:SF2">
        <property type="entry name" value="HYDROXYSTEROID (11-BETA) DEHYDROGENASE 1-LIKE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026031475" evidence="1">
        <location>
            <begin position="28"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0743020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="296" mass="32356" checksum="706C5E7130CC3062" modified="2020-08-12" version="1">MFIKSAIVAAFAVFLVWLMLPVTQFSGDHGEIIRGQNVIVTGASQGIGKALAFEYAKRGAAQIVITSRSEVKLTAVKDEINLLYPNATIHVVPADLSSEENSKAFVVAALTALNQTLDVLVLNHILPSPYGYWLKSPQDHSVLSQLFHTNTFSHIWVATAIVEALAPRGWMIQIGVVNSLASQMGVAKSAPYSASKHALYGFFNAFRAELSILGIHNVVITQCMVGTTDTEGAAVAKNEMKNVHWDAPEVTATGIARGIAFQKREIYQPHDFIYPALKLYQLAPWAMEEIFKSMLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XSA2</accession>
    <name>A0A6G0XSA2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_001956</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000019">
        <property type="protein sequence ID" value="KAF0743267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019779"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1470.10">
        <property type="entry name" value="Photosystem I PsaD, reaction center subunit II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053233">
        <property type="entry name" value="ABRA-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21715">
        <property type="entry name" value="RH04127P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21715:SF0">
        <property type="entry name" value="RH04127P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="3">
        <location>
            <begin position="53"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="174"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="336"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="778"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1275"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1085"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1529"/>
            <end position="1619"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1696"/>
            <end position="1723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="778"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0743267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1940" mass="225030" checksum="33D41F1663992DF2" modified="2020-08-12" version="1">MDGGQGDSIVLEEEIDPNYEPTEDEVLEYAKWLGMDLEAERDLFWIAREGLKAPLPENWKPCKTTDTGEIYYFNFATGASTWDHPCDEYYRKLYDDHKKKTIQGKKFQDTDDKKKKEKEDIAEILGKKSKKAPKKAPKVESLSTVKAGLDKKPLGAINKLPLSGGLNALKPVATLGKPSMKAQDDSEEEEEEKTEVIKSFSRKPLGAKDKDARGAEELENKTQELSERIRQLEEEHEEKVTVLKKKLEQQENELLLEQKAIEKKLQKLQKDHADEVESVKELEKKLSKRRKDLEAEHREYIDNADSKFAEKKRELIKKQEKELKEMDEKHRETIQELDAAHENELEKQEAERRKQEMQQEHRQMEENNKIDKLNAEIETLKTEAQQYKRQVKTLEGKLREESEKPTQAPETVTELEASVESLQNQVNKLNSQLAEREKFVQALETKLKDLAKEFSEQRAEPSNLNKEIEQLEETIKSLQRQLQAEQEKVTEVDKASKSWQEKYMELASKEPSEDKNGGWHDKYLELEQKQVEDASSHKALSDKLQSKIEILESQLAERAAADPASDEWKIKYDTLSAQYTSLEATCNAAQAKNEEWSTQCVDLKAAVQEAEAKMQSLVDDKNSDNARLMGKVQEVESLIAAKESLEEKLSDMASTHTTTLRRLEEELREARNDASAWQAQYEQVLASSSQDDGIKDQIHQWQHKFEELQARNDTIMAESQKNIDKVEAKSKALEREKISAETMWKKKYDEAEESWEKQLTQAKASINELQAKWKTLQSQESSTSGIASSLQQQLEEAHRQIQESQDSLEDQQKQHKRALDNATALTKQQLEEMQTSHTAALQAVKSDLVAVESAKRKLDDQRATLERKLKQKESEIATLMTQMQDHQKMSKETSNSMWEWEKDKLTTQLRAAEAEKDEVDGRLGALRVEHDALLNTYHKIVLEKDATEKKLKQVDAEREQLGQKLKGVEKELDVVQTKWRATTTEATELKAAGNKLKLNLQTAEAQLEKAQEECRNLETLVKQQRDLAEKSQAEARALQIQLDDTLFQKQRVEHDQLTVQHEVDRLKEQLALRSSNSSLSSSAEKESLRQQIDQLSADARAANDKVRLLQGKAQEFETKFKQSQDTYDRHAATWSTEKQAAVDKLEKLRAQHHQLDRQHRTTVQEKADIEASYERLQQEKVDLEKRMKQQQDALTTAQAKISDVVHQLDDAETQKRTLGYDLQALESKFKRSEQEVERTKSELAARNQEKEALETKWRQDVAQFEVKLKSLRQDQTDQWSKRSVEEENKRDELTSQWKKDMEDKKKEWQARVSQLESENSSLQNQLTQVSKELAAAHKDVEHITTMKQKQEAQSKSMAEQIEQERNQMQESLDQMKTKLKAAQNEKDQLMMAMATNQNEQPMPPSMAPTSFDIGSTQVKLQMAQVNKTELEAHLQEVTLQCETWRRKAALLDSRSRDQALEMEALHVENAALRASAQRMHASVTESLTTIERLNYEHKKRMLRSEYMAQLREFSEREELALARQKARVRASCERQLEELVAEFERHKASRMEQEERDFQEALNHCQAENKVKLAQVLKEHRDKMASVEQEMQGKQQRHIQNLSKQMQEEEEHLAARLRDTKQLNREEDLCKVASLQPGTFESHLKFERKEVSAAPVAPVAPYQSPRARKKKSLRADHEHVWHKRIQQEQELLDKAKQFLAKQKKSLKQRMAKLQDEKDWWQRQPTYNVKARNDTRLLLEQHAQQLTHDAKVLKRTEKWMAKRELKIRKMEQACSNNNKWHEDYDEDDEPSDSSMDFVLDRLQQELLADGANMSSHLQEYAREQCAADVLPWPSESQYHQTEDIQPAPAPMYHGYPSVISNNRWLYRRQPDRVSAYESYMTPARRTPLYDMKLSNWVHNRERASAAASAHSNYLQQLSQELKSYSSKYKAEHSEGELDALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XST9</accession>
    <name>A0A6G0XST9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein mS33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_001897</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000017">
        <property type="protein sequence ID" value="KAF0743426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XST9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011707"/>
    <dbReference type="OrthoDB" id="6495301at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013219">
        <property type="entry name" value="Ribosomal_mS33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13362">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13362:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08293">
        <property type="entry name" value="MRP-S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0743426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="95" mass="10692" checksum="7F8ACEFCD3A3CF81" modified="2020-08-12" version="1">MSTSAVSKQLADLSRKIFERLPQNHTKSGNKILSAQLKGEKVASWFTKPLALRVGGYSEYYQKINQYRLDTNAQLKQQGRGPPKKGAGKRSQKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XT33</accession>
    <name>A0A6G0XT33_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_001798</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000015">
        <property type="protein sequence ID" value="KAF0743504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XT33"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004002"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026167870" description="Major facilitator superfamily associated domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0743504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="351" mass="38704" checksum="A635CB57EF5EE042" modified="2020-08-12" version="1">MTGVAIVIILALTTLVIRTPPVTFTANGHDMHGIPVSKAPDPQVVNDEYLKIGMTFVNYSVVQSELEGTDRSYFQHVKALSLLQCIASTDFLCLYIAFAANIIPALMFSTELRDISIGVFGESVEVTNAVLTQGLISNSLGRLCVPLVSDLMIRIFYTNPAFSRKAVFAALLTYQLVFLAVVPKASITFGTFRWLGLSFVFASGGGLALIQCFITDLFGVYHAGTMYGLIMTCWSLRAVVLGYAFTSFKVTHDSFTDQLQWMLALIILGWVAMLFVRTNSMDRFFYGYQYSLCGKVIFQWAFLRVPSDTYDVEEESVTILAPPHASALSEDGFILWQSDSAKSLAPLNLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XU29</accession>
    <name>A0A6G0XU29_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_001288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000010">
        <property type="protein sequence ID" value="KAF0744147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XU29"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019757"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="1">
        <location>
            <begin position="176"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0744147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="283" mass="31182" checksum="DA9B8637045704EB" modified="2020-08-12" version="1">MLVLNQTPSETIGGIAPITAMTGSKPMSPLDLILIPGSAEVVTLQELWDCRLQELATLQNAVEKMHQEVSDASSSKRQRGRAARAKKKGVKMAEFDVGDYVLYMDVWGVSPSKLNVTWRGPAQVVKATSGWMFEIQNLITGIVREAHASRLKFYADESLNVDEELLSHVAHNANGHVVDHLVDCRFKPKTAAFEVLVSWRGLEEVENSWEPATNLQEDIPVVLKRYVQEHGDKEVVSDMTAALGLDQVLGGIVANWTFAEALECVQETIQDSDHFNATCAVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XU78</accession>
    <name>A0A6G0XU78_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HhH-GPD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_001622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XU78"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000795"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21521">
        <property type="entry name" value="AMUN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21521:SF0">
        <property type="entry name" value="AMUN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0743982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="24936" checksum="5EDD757FC3D1FF18" modified="2020-08-12" version="1">MSNLWKSESADDWERVFAKYDEVCASLEGNLQELEKWYQNELPALVQQQGHITQPQLSKLMQWKLSKGKWRPRLQSFVDGLPKKDVQDLSRKAFAACKKKAYKEAITEISSLKGVGPATASAVIAAFDPTVPFMGDEALNALSGVIGARQYTLPHFMRFLDALQAKAKVLSSSNEAWTAQRVQLCLWLEVALSSSSPASKKKRPASKSASTATETSTKRARKSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XXZ5</accession>
    <name>A0A6G0XXZ5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_000371</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XXZ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005265"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037176">
        <property type="entry name" value="Osmotin/thaumatin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49870">
        <property type="entry name" value="Osmotin, thaumatin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0745345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="275" mass="29575" checksum="C6136B63A59F2DAD" modified="2020-08-12" version="1">MMSQRSGKDEPWTYAEGPPCLDSIVAASSIAPEERATFTVWADETSWHNPARDGKVEVKSVDGSSVARTQRNARRRMFAMLILAALGIAALVLLVLGFSKKSATQSQSTAPPASSSTSLNQPMPTAAVATTTAPPAGILDTPGALIFINKCTTEFDVYYTINMPHDMSEVSQRALNSSTLAMVVPGANWTDYIAADFRLGNSTAATIFAANRNNDNIYYTVSTGSGFNVPILAEPVHALRIGCPAILCTYRGCERNRTLAENCSWVEPLQITFCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XXZ6</accession>
    <name>A0A6G0XXZ6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_000459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XXZ6"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="1">
        <location>
            <begin position="58"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="1">
        <location>
            <begin position="94"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="1">
        <location>
            <begin position="180"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="1">
        <location>
            <begin position="220"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="1">
        <location>
            <begin position="255"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0745442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="291" mass="33833" checksum="FA4851521031E664" modified="2020-08-12" version="1">MHPLRKFGTIAADRLAWYLVCLKTSFFPSSRRIRPNAVLNRVEETPPLVKPSPEPTVPPLPPGWKVYSSRSRGDYYYVNPALNLKQWNHPAPPVELPLGWKAYWSQDDAGWHYLHKEYGLKQWEPPTVTPSGTEELPPLPLPKGWKGYKSRRNGHWYFKHKALHLRQRYYPLDAEDSPVDALPSGWKMYISSDGTPYFKNKSLRVLQWEVPTKETVVPTEPLPDGWTYVKSRHGKWFYENADLGLKQWEFPLPEGSLPPGWRAKMSRAKGRLYYENKALKLSQWTRPVQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XY85</accession>
    <name>A0A6G0XY85_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_000482</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XY85"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018130"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF7">
        <property type="entry name" value="F-BOX AND WD-40 DOMAIN PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="165"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="203"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0745468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="457" mass="48935" checksum="9EFD488D2BC7C0C2" modified="2020-08-12" version="1">MSRSRTIRFEEYASSGPVTSSVVCQAEEVKPSKSTARFAASKSHQDNEKYLAAFDSNPQKARQPAKVSTESLPTIAPAATSIPPLRETHTETISIDDSARTPWLQGPNDPSGRAEAVSAQPLTCMSLSLDESEVVVGSCDHALYAIPLRKTKGKGGSVRTLYTKTSGHGEWVTSVAHLADDRVVSGGMDSKLCLWEGNRCEDLTGHAGSISLVRVYSDNMIVSASYDKTYRVWDGSAGKRAAKNGRERHCLKGHDAPILDFAVWGGSRLIGGDRNGSVLFFDLSQGAVEKTAKAVHAGHCTAVLGSCHSTDQAFSGGQDGILRLWDVRSKAPVFELACHAGQKGTGAVSFIQDMPTMEHVVVTGGADGKVQVVDTRMPGQVRATFSEHSTFIYSLHLHHDLCFSGDGAGMLLVHDLRTDRLCYGLGANRAAVRAIISTQRQLIAAGDDGSVLIYDFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XYY4</accession>
    <name>A0A6G0XYY4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_000186</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000001">
        <property type="protein sequence ID" value="KAF0745737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XYY4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019205"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="49"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="230"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0745737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="351" mass="39895" checksum="4EBE4AA1798725B8" modified="2020-08-12" version="1">MEIMSDVPMSHADDNNNDDSVQLSESLLVDLASEPLSEPADGVQEQLKKQSLTDRLVTALREVEEQRRLLEAAASNGTLLAEKYFALEQERDALRTQYMETKEALEELEAQMKHNNRAATSVQKCIDLEQQLNTHMREQGVLDETRARQEAELMSWRTKALEAAKENARLRELVATLEKERETAALSRQHVTSINRKVQSERDELLLHVKDMTTRLDEYAVRDHRLTLSNDVKQQKIQRLEALVEELQDDLARANVELVGSVETAKQHENTAKELRGVINGLKRSLSSLQEDYQLVVEKHNLAVPEKSDDTTKVPVEKTGWEHFLVVVKSIKDFVAHLADKCTGGFFPLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W4M0</accession>
    <name>A0A6G0W4M0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Nucleotide-diphospho-sugar transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_019001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MNN1/MNT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000372">
        <property type="protein sequence ID" value="KAF0721668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W4M0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009907"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000033">
        <property type="term" value="F:alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31392">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE MNN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31392:SF1">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE MNN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0721668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="440" mass="50505" checksum="ED27C30480445332" modified="2020-08-12" version="1">MPILMGCIVLLLIVYIYVINSMPMIDGKEVYLKISKDQWLTDIKLFQNFSHIKRGIVVCLFDAMVPMAASLVLELRALGNTDLVQMYHCNGELSASSQRILYMIDANVEIVDACKSFVLSGKLPASKANGFRSFWLKPLALLHTRLDEVIILDADDLLFQDPARLWDLPGYKQTGTVFFYDREVAKAEYLNHLAIVRFQRMTNLRALIESFDYAKFGLRRNPSVHLENTLAWNGDSGHEQDSSIVVVNKAKAPLAMEVMWQLLLHDRYSIEFSYGDKELFWLSFELAQLPYFFSPWANSAAAMPRDMEKHPETLCGGLAQWMPSRDAKGILLHINGGYILNPYRKNNIHSMRDAQERTQELLAKIPRHVSKHRTRSKGLTKPEDYSNPDGFWPQECMFNRGSEPMREQDIESIKRRIHSAVGIAQLQQREIALDKLLHKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W4P4</accession>
    <name>A0A6G0W4P4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_018760</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000352">
        <property type="protein sequence ID" value="KAF0722010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W4P4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005906"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF360">
        <property type="entry name" value="ULTRAVIOLET-B RECEPTOR UVR8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="427"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="478"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="530"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="581"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="634"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="688"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="4">
        <location>
            <begin position="808"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="139"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0722010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1120" mass="125927" checksum="9219F85C8C20AB58" modified="2020-08-12" version="1">MDVPRGFGTIRDVRLIGFYSAKDPRSDRHFVVYVIEVTLDGGSGSFLIYRRYSQIAVLSTKLHFETSVGLPPKYALQPYPLTDEQLSHRFDGLRRFVEQVFAQLKQKCLQGEQHKESSSAGLDMQVFYDFLHVHKNRPPPPLHPPLPDWASPTDSPSNTPSNLSSVSTESLDGHTWGEDSEEFVSISTTNQDDSTFASNRLRNDILQVESQAHALWNCVQAYVQAAHTFAQATSAVQMEMDRLAKMPLVNISSESLSSSCPIDGWKHLHDACGQGVIHPVRNLCHEVFPDVKQRFWNNTTIHPLNRYKTERIALETQLQASIASAISAFRDAHNQFIETQTLITPIPVPVTSSMDILQDENSIDETLPEPAPATATPSSQVYVWGRLPDAISPQPLLRPTKHSIGIGQDLAKVACGGDRLLFLTASGEVYSYSPDEKGQSFESPQLVEQFALDKALHRSVIVAIACGPQHSLAISHLGELYTWGSGEDGRLGHGDIRDRHTPRKVMSLLGQQIVQGSCGGAHSAVVTASNQLYTFGRGKHGRLGLGSNVHFHMTPEAVASLCQWKQVFCGWNFTIAVSVQGQVFSWGKQAEGQCGLGYIEADQLTPVLIEALSPYNIVHVACGYTHTLAVSDEGELFSWGLGEYGQLGKETIYQPVPQIVDVSTCLADDRVTRVYCGAFHSVATTEHNVMLTWGLNVYGACGLGHTINKDTPERLDCFNRGYELIVACGHKFTMVVERLNGPSVDLSPSQTTHGSFQKEEDLRRTKKVSWLLKKIESINYRKLWRTRILRDWESAKDSPLAHTLWRQGIPPSLRSKVWPLAIGNVLKITPDMYQLYRERAAQTRLGNMQLPSDGREHTVKLIHTDLPRTFPSLKLFDTSGPYFGYLREVLETYACYRPDLGYIQGMSYIAALLCLHIPTDRYLCFQCLANVMVHEHLFTFYLLNIELSNDYYILFDIFFDVQLPLLRQHLSHLGVPSSMFLMNWLQTLYLQVLPLEVASRVFDCFLLDGVLFLFRTALAILTMLGPKLMQSELDEALPLLQRHHMYHTYWLEILPEDKLFETIASINTPSHVYMGVEQLVQNVYFYQPGSTSPSFPQQKVRRRRSRYAMSDQLDGFMGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W574</accession>
    <name>A0A6G0W574_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fatty acid desaturase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_018539</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The histidine box domains are involved in binding the catalytic metal ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000339">
        <property type="protein sequence ID" value="KAF0722323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W574"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002097"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF101">
        <property type="entry name" value="FATTY ACID DESATURASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="12">
        <location>
            <begin position="57"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0722323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="344" mass="39743" checksum="60D1E0A56AC3F322" modified="2020-08-12" version="1">MSRQVDSVAADQPAFGSPTPSFDWKEVVWYNVFILATWHVMAVYALLFVLPSTSFTAILTLWIALWWFSGLGITAGAHRLWSHRSYKARLPLQIFLALCNSMAFQGSIFEWSRDHRVHHKASDTTGDPHNSRRGFFFAHCGWVMVRKHEDVRKEGKRISFADLETDPLVQFQKKHYLWSVLLMCYIFPTAVGYFMFNSAWLGFWIGGIFRHVWVLHMTWCVNSVAHFFGYKPYDRNSRAVENLFVSIGAIGEGWHNYHHRFPTDYATGEMGVTGQWNPTKAFIDVMAYFGQAYDLKRSKTAAATREKVKIAMDEEALKGIVQPTTTDQFVNWLFFGRTEDQSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W6A7</accession>
    <name>A0A6G0W6A7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Queuine tRNA-ribosyltransferase catalytic subunit 1</fullName>
            <ecNumber evidence="6">2.4.2.64</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Guanine insertion enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA-guanine transglycosylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_018328</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>guanosine(34) in tRNA + queuine = queuosine(34) in tRNA + guanine</text>
            <dbReference type="Rhea" id="RHEA:16633"/>
            <dbReference type="Rhea" id="RHEA-COMP:10341"/>
            <dbReference type="Rhea" id="RHEA-COMP:18571"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:17433"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:194431"/>
            <dbReference type="EC" id="2.4.2.64"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer of a catalytic subunit and an accessory subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the queuine tRNA-ribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.64" evidence="6"/>
    <dbReference type="EMBL" id="VJMJ01000330">
        <property type="protein sequence ID" value="KAF0722595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W6A7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002181"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008479">
        <property type="term" value="F:tRNA-guanosine(34) queuine transglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="entry name" value="Queuine tRNA-ribosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00168">
        <property type="entry name" value="Q_tRNA_Tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004803">
        <property type="entry name" value="TGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00430">
        <property type="entry name" value="Q_tRNA_tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43530">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43530:SF1">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="tRNA-guanine transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-guanine(15) transglycosylase-like" evidence="7">
        <location>
            <begin position="25"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding" evidence="6">
        <location>
            <begin position="279"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding; important for wobble base 34 recognition" evidence="6">
        <location>
            <begin position="303"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="105"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0722595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="422" mass="46314" checksum="AE018A1EFACAB45F" modified="2020-08-12" version="1">MAPHKVEFSKESPALKLDVLHTSGRARACDLHLPHGTVHTPIFMPVGTQGTIKGITAEQMGLPPIDCKILLANTYHLALRPGTELLRDIGGLHDFMGWQRNILTDSGGFQMVSLLELAQITEVGVEFQSPVDGTTMLLTPEMSITHQNNIGADIIMALDDVAPSTIQDNARFLEATERTLRWIDRCIAAHKRPESQNLFGIVQGGYTVMSSSLKILGKGGLDTKPGGLRERCIQGLIDRNLPGYAIGGLAGGEDKTSFWTVVALCAARLPANKPRYLMGVGYPVDLVVCSALGVDMFDCVYPTRTGRFGTAITPKGLLRMKSAEFATDAGPLDATCACMVCKQYSRAYLYHVMKKEGSIGPQLITYHNVAYMLNLMAQVRQAILDDKFPTFVRAFLKEWHQGSEIPQWVKDALNHVNIFIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W6J7</accession>
    <name>A0A6G0W6J7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SMP-30/Gluconolactonase/LRE-like region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_018210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000326">
        <property type="protein sequence ID" value="KAF0722731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W6J7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000640"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46388">
        <property type="entry name" value="NHL REPEAT-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46388:SF2">
        <property type="entry name" value="NHL REPEAT-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0722731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="389" mass="39538" checksum="0DCC04801E03EE90" modified="2020-08-12" version="1">MLQPADGVAFDMIPQDVAANPTSIAAITDSDPKPDDVGAAKTDVAVVDKKKKIPPIVFVPLLGAFLVITVVPSVVSNVVNKNPTPTPAPAAPSSGSSGGITDGFVTPVPAPTTSYSIATVVSNTPVFDVAFHPVALTWAAINSSTVWTASAATAAGLANRPNAGGFHLTFDSAGSLFVSTANQVIKYTGNSTTISPTVPNATSVCLASTGVNMIAIGGMPSLPLSLWNATSNATTAITTTPMNASDMAIYQTTYLYVADAAAHCIRRVAFRTGAVDVFAGSCGVAGYMDGAAASSLWNGPSGIAVDYYGVVYVSDTGNHAVRKIDGTTVSTLVGTGSPGNVDGIQGATLNSPGGLAINAQLPWKTSPTSYFGLYVADTGNQCIRLITMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W897</accession>
    <name>A0A6G0W897_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">malate dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_017693</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="2"/>
    <dbReference type="EMBL" id="VJMJ01000309">
        <property type="protein sequence ID" value="KAF0723351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W897"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000837"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004773"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005687"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017352"/>
    <dbReference type="OrthoDB" id="4069699at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000010">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010945">
        <property type="entry name" value="Malate_DH_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01759">
        <property type="entry name" value="MalateDH-SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003916">
        <property type="entry name" value="PRK05442.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23382">
        <property type="entry name" value="MALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0520">NAD</keyword>
    <keyword evidence="3 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="9">
        <location>
            <begin position="5"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="10">
        <location>
            <begin position="155"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="128"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0723351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="340" mass="37003" checksum="DFE0A33D97687B1E" modified="2020-08-12" version="1">MGVLNVVVSGAAGQVAYAFLPLLCSGRVLGPEQRIHLRLLDIPQSVEIMGGVVMELNDCAFNLVDDIVPTTDPSVAFENADIAILLGGFPRKQGMERKELIAKNGSIFRTQGEAIELYARRTIKVLVVANPANTNCLITMKHAPSIPKENFTALTRLDHERMRSLLVKRIHSTPEHREISSAHVRNCVIWGNHSNTQVPDANHVVIHAPDGSLSPLADYLQDPEWIDNELRPLVQNRGAAIIQARKLSSAMSVGAAIAGHMNDWLFGSSELVSMGILSTGNRYGVPDDLIYSFPIKCLGNGKYEIANVAVAPSIAKLMQVTADELEGEKAEAFARVDSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W8E2</accession>
    <name>A0A6G0W8E2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_017530</name>
        <name evidence="8" type="ORF">Ae201684_017531</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000301">
        <property type="protein sequence ID" value="KAF0723563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VJMJ01000301">
        <property type="protein sequence ID" value="KAF0723564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W8E2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007729"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF349">
        <property type="entry name" value="AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="362"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="6">
        <location>
            <begin position="14"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0723563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0723564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="490" mass="53025" checksum="48B3360ADC262603" modified="2020-08-12" version="1">MGKPFLTLEDLKMCFSLFCCVYGVGTLSMPKNYASAGFVWASLALVFMAIVNIYATVCISKIMLVAPKSVRTFADLGEFSMGKTGRWLILITQMLTCIMVPIVFLVLGGSILTILFPKSYEDTTWIILMGISLLPVCLIPTLKEGAFAAAAGCLGTVLADAIALYLLVDNMEPASKGFTTPKPDVGFKQVAGVFGSLALAYGAGIVIPELQREHSEPTRMPRVIVVTMGLISVLFLTVAVTGVSFVGCQIPGNLLFSIAGSPTALGFTANRGGVILACLFMQLHVTIAFAVIMNPAFFILEGLFLGLHKHAFGTPEIEAGYDAAATPDGEKVSEALEEKEFNEHHDLDSKTYQAPGVYPKVAALRIVVVAACVAIACAWKDHLSDLLDFTGASCLSLCCMILPMIFYMKVLWNKIGALEKIWIVIAVLVCLFLAVYESIETGKVLFKSSTKQPDTWDKIKFPYCPAGSSYQRIVYTNVSYHANYTHTTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W8W8</accession>
    <name>A0A6G0W8W8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_018046</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000319">
        <property type="protein sequence ID" value="KAF0722971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W8W8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010212"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026216225" description="GOLD domain-containing protein" evidence="9">
        <location>
            <begin position="29"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="10">
        <location>
            <begin position="128"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0722971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="298" mass="33597" checksum="2550B210F04D6D22" modified="2020-08-12" version="1">MSNEKLESNKQMRLAACALVALIASVLGQETTLEATTRTVTTPKPTATRETFEPDRYQHEPPGQTRLGQTTKVVDDFDPYKIANDAAHAMGQMGKEAPPKDKQEDGKLSQFDFDPSEGLTFFVEPRNKMCFYEDVKSLGDTVGGAYIVSTAASSIDVDIKDPYMNTIFQRYGDAEGTYEVHPDVTGLYEVCFTNNDHDDKLVTHVTHTLQSQHPVEKEHVSILAKYASHLDIRLGELESEQRLMQLRVDRHMKTEKSTNDRVALAGTIESIVYVALVLLQVFYIKRLLEKPRQVRNWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W957</accession>
    <name>A0A6G0W957_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_017493</name>
        <name evidence="2" type="ORF">Ae201684_017505</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000298">
        <property type="protein sequence ID" value="KAF0723642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VJMJ01000298">
        <property type="protein sequence ID" value="KAF0723654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W957"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006492"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0723642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0723654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="466" mass="53619" checksum="69EE089E973E3912" modified="2020-08-12" version="1">MDRQVRQKPNDDGQLVIASHQGTKTILAKLPIEVLVKIVFSIPDAAEMLAFLELLRPYVTLGPLEYLYQLGCSMDHDDLWPTLLLCEETLETLSGTPHEAIVQYYPNLKIEFEGTEAIEWLRTHLNPRTSIEWCVNDVPAAVENVHFWANMRITKASIMIENETESMWKNLLPRLDHVVALHVAEEFGNLEDIYAYVAESKQVTEFEIYSHSGYAIRRSDVVHLIKWFRRQPVKVYESWFTNWSALDWKLRQECCEVMLNCPTLERLRLSDCYLDDMDFSRFRFSTKSLWLDAFDSDNLVSLARQLEGSGLKSLSLTDAFDDEGNFEGIKSLLTALPQSSITILSITEVDLSNKDWCKLAHLLQKCHLESLEVEIAVMTSALARSFAKAIQKNRSICEFHLCKCDIAVENLKILIRSISDVNRHVQSKQIKWTTLESKKIKDADVRSLEEFATECGCDFVHDRVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W9F8</accession>
    <name>A0A6G0W9F8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">U2A'/phosphoprotein 32 family A C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_017389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000295">
        <property type="protein sequence ID" value="KAF0723814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W9F8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018252"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042655">
        <property type="entry name" value="LRC72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46759">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46759:SF1">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0723814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="525" mass="58119" checksum="8FF4D28579ACCEC2" modified="2020-08-12" version="1">MTRVTASLLLERAGIYEVLGTKELILRDEAIDELEETCAKDLVSLELLSLSHNALRTLTHFEHLTNLIELNINFNHVESLDGLQCYGLQKLYAANNKLTSIAPLRAFSKLVHVSVYGNELSDLDAALHTCRQLVKLRSVDLDGNPCARTKHYKYQVLRLLPRINELDGETIHALDREMLLEQEPPLAPTPRSSLPPGPPIDLAEAADSRGPAQLFRDEFLNNHPILLEYLAQGVQDADPPQASADSMASPRPPSLFVDKMRLANPDRTAADQEQPQVSMKCPMAATPTVVPSHGIVDPSDPNATIRRLLKHIDHLTSSLDASRAQASDQAIAALLEENSQLRIENSNIPILQDEITSLKYQLRHATQQTSQPLEAENAALKRQIAKLRSMLAAKEADSPELTKEQVLEEAATVDVELTALIMQNEISLQIMRQTIQKTKLDMLNDRVAQMTGRYRPSTSAGIATKAMPSPATPESPQSGRPRRRLHTSAGHRPSKSNLSTSFRRDKKIPTVVEEDNNTTADLLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W9K3</accession>
    <name>A0A6G0W9K3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_017270</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000292">
        <property type="protein sequence ID" value="KAF0723889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020780"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="1323"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="150"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="82"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0723889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1450" mass="162960" checksum="DDCA0D3138435607" modified="2020-08-12" version="1">MNWRDSKNPPAYESLLPPQDHPKRPVHFKPAASTKKPDQRHIARQPSKNDQSPSSDGNEDTSDERAIEFGEFFVVGGSSASLRALESEHRSALARLRDQQKLIDRLKHDKAVLEDQIILMQEDMRLQQHVQHSLVASKTLLESSVLPHLSVMESSPSRPNGRAPPRPSTQGRASPRRSSAEHISLAEKRELETLRLKVHGLEQERQQRNEDFATQTKTLIRRIKKLQQELNERDEVIRTKDVQINLLQIRSLHQTHPLHGNHSSPRMLSDDMWLAVPSLKSQIESNTGRSSVNGAFDALVSQSLSDSLRRLPGHYQEQWLRELQITAGKLSCLHSGLKAMCGVFHRLASCSDLFEMVRLIAAEACALANAEEAFVFIVDPLQKHEFWSRSTRADGEVVTSRSLIPHMTLEHQLAYSEYLAKEIEHPTAHDVSISAANIQATLQSENLSNKQTDTLQTQFLTEPPPGFAAYVYHTKEVLNIPGCKVLGHPLYSSSHASTDRFTKLKSSATMLLPICNGDDRQAIAVLQVCGKIQDFRGMGVHVTVENCLPFTEEDKWLLAGLSNFCGGLMAKVMTFTEVERTRKSEKVLLSLSRQIFTCLDFPKLSKLVMQSTKELLDADRCTLFITKTLPNNDHVLSAWQSDIDSGTVHQPYKNRGTEVVVHFGHGIAGVCAETRRLINVPDAYEDKRFNRAYDEKTKYRTKSILAMPIISSKDSLLGVIQMINKSGGTAFKSRDEEHIVAVSQLIALAMENNNLFQKTQDVSKCIGTYIRHLTLHEALINMTLHAEEIVGVQGACIYLVDERTNELFTIHRVRKTRVDLKPMSYNIMEEALSLKEPLIVNNVSQYLHFNPAVDSLQGIGAQQVMFVPLFQYGKQGVDDKTFIGLLHLVNRKGTTHDFDYDDSLVSIIANQVSGVLMSIIERQAMLQLHEDTKMLLETCMSFYKELNHVGIMNAVYNASLTTFTIERGQLWLWSDDKSSMWTSKLLPTEDTKFINPMLQRRLSVSALERIQVSCSEGLLKRIVTEGKVVSIRRWEPSLSDINVEGVQRITVTDRNAGFTDHSITACPVWDSFGIEVIGVVVLMYPRGRNLHRLELSKIPIFTRQITGALMVCRDVAQHILRVQRMQNLLEEYTATTQASATLFNMSLLQASSQSNTSSPTSQGVSLAIKINHGGTLHSATYPINMFTRGLSSCSKYDLVRLPMDSRGNRHIIQVTCAAQAHCEGSSFDKWMGREVVGDWEKIKFDLHNAFSRKDTLTAYYSRSHAASIAYVNNMAEFPVASSPSTSQTSIISASSPSKLEIPDTIRREIAVFLWLFCMQDLKIHLDKVYALFASFDADATGFVSPTDLEYVLQAWGVQLLPHEYDAIFKAFGVPVDMDVAPYFENGVDPDGPIHIPYKHLFKALAPHFIRHAEFHHEVFPTLHPTTHAVTSVQLFLTPTKEGVIVPTIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W9L6</accession>
    <name>A0A6G0W9L6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RNA helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_018106</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000320">
        <property type="protein sequence ID" value="KAF0722875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W9L6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010651"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00268">
        <property type="entry name" value="DEADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044742">
        <property type="entry name" value="DEAD/DEAH_RhlB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="113"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="313"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="603"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="603"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="635"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="668"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="688"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0722875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="699" mass="76642" checksum="08F3FAA0FF27BD53" modified="2020-08-12" version="1">MLSKLLLVSALGRRSLPKAVVALRHAAASTTVPSYAMPRLASRTFSSLRLQSIAIQDEDLTDIDDDLDIEDAESTSGFANQKPLADFDLSLQTLQNLERAGITHLFPVQVESFSTMMDGRDIMGRSKTGSGKTLAFALPIIERILSNPSRSKSPRAVAMLPTRELAQQVADEFRRIAPQLRVGLVVGGVSYTPQENELRRGIDILVGTPGRVVDMMDKGALDLSEIEVSVLDEADMMLKFGFQEEVETILGAMPESKQCVMWSATTPRWVHSIAKQYLNDPVTIDLVGEDNSKLPATVAHKAILVSRDSKDHVLENVLNLYSNGGQTLIFTETKQEADNLVASISSRNKGVRALHGDLSQGLRTSTMQSFRSGETRTLICTDIAARGLDIANVDLVIQYRMSNDQENFVHRAGRTGRAGRSGVNVVLFEARDVGDVRELERKFGLTFSHVAAPLPSQLLDNSMETVRAKLENVAFDGRKAFEDAAKAILDNEDERLHVVSSALALLAGFEEKGPTVYSMLTAQAHLQTLTLVGDRSWNADGISSFLKEVQVNVPFSKVVRGDSHVFYFDVPRKHVDAVLQHAETNQVDISIATEFPKITLSGLRTSNYSSRPPQNVRQGYGNNIGNNRFQRDSNNRNGSRFGSNDGYSNNRNNYSRNNNRGGSGGFDSGFSRSSNSQGGRKSSSSNGPSWANKSSSKWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WAM8</accession>
    <name>A0A6G0WAM8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ae201684_016962</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000273">
        <property type="protein sequence ID" value="KAF0724297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006135"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021502"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001518">
        <property type="term" value="C:voltage-gated sodium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022843">
        <property type="term" value="F:voltage-gated monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005248">
        <property type="term" value="F:voltage-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000009">
        <property type="entry name" value="Voltage-dependent T-type calcium channel subunit alpha"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031649">
        <property type="entry name" value="GPHH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043203">
        <property type="entry name" value="VGCC_Ca_Na"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10037:SF62">
        <property type="entry name" value="SODIUM CHANNEL PROTEIN 60E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10037">
        <property type="entry name" value="VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16905">
        <property type="entry name" value="GPHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="171"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="376"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="475"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="521"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="611"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="693"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="768"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="801"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="865"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1039"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1119"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1144"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1183"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1232"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1350"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="1386"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1543"/>
            <end position="1592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1547"/>
            <end position="1559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1560"/>
            <end position="1583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF0724297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1592" mass="179272" checksum="B4DC3491E5E4108D" modified="2020-08-12" version="1">MGDDKAHHQDSFQSQHIYGHLRKFQRISLGCLTAKHPVRKVCIHIVTWKWFDRFIVACVIFNTVILALTDYTNAWAEGPNATIWINSFIDKCNSISFYIFLVEAFVKVVAMGFCFGEGAYLSDGWNRLDFIIVVSGLLSIMNIKGIKVGFIRVLRVMRPLRTLHSLPGLKVLTNSLLASLPALANVFVLLMFCMLVFGILGMEIYRGAYHFRCRVTPYPVVLPPNGTYNYPPNASYIAMVQAAPDQFMCLLSDGTPINQSQSVWDTPQDCFWPTDPSEPFPQVCNEESNTGRQCLSPGTICGSNFDDVGNPRFNYLLQPPWTGNANDDALFNSNLNYGLPSFDNLGRTWLILLQTITASGWMVLTQTTQNTASPVVAAIYFTTLMYIGMCFLLQLNMAVLFTEFEKAKDQQNKKMRQEMERRSVVLASMTKSSRAAESMTKKYLAKLVAATASRRGDIVVQSAFSRNIFAFRNGVYKLVISPVFMNIGLVVTMANILILAMDYHGIDVETKSNYETANFSFMIYFGIESALKIIGMGLRPFWKDNFNRFDLLTFVMGVIEAAINPPAIIDGTPGGGGFFTAFRAARAFKLARMWKSLNQLLTAIFNSMGEILNFLLFLLLFMLIFSLIGMELFATHYQFDPNNFYMTFNNTNPQTRLHRSNFDSIVWAAFTVFQILTYDNFPSVMYDGWISVGVWAPIYCSLVIILGVFVVMNMFSAILVQAVMEGNDEDSEIDNDDDDGVSCIDTALDTPLLDPSSTLGTYLDRSNLIFAVLFTSEMTVNVISRGLIFGHDAYIKDAWRILDGFIVFVSILPYCLGNTKSGAFTGLRSLRAFRALRPLRVINNIPSLKVVVNTLFRCLPDVGRALLFFSFMLFLFGLMALALWKGANYTCSVSPYNYGLGTGTPNNPPWFPSDYTGDFNVYDIPTLQLIDVMTFPIPWNNMSRAQRDPFLPVWNQTGCGPFANDYTPTSKEICLCFAAQNGTSWDTQTPQRYDNIFYAVAGLFELTTMEGWTATCLATIDATGEDMQPLANNHPGYMIWWWIFIIICAFFITGLFIGVLCDSFARETYGSMVTDEQISWIKLQNKVLALSPLHVFPMPKSRFRAKLYKIATHAYFEPFITFVILLNTACMALNSFGQSHTSEIVLTTINTVCSYIFIVEAAIKLPSFGVGYFESNWNRFDLIIVLFTIVGFILDAMDVKVGSAASITRVFRVFRVGRAIRLIKKAKVMKSLFDTLIVSLPAVLNVVSLLSLLYYIFAAVAVQLFAKTAFDNDMINENQNFRNFWMAFQTLIGFSTGENWDNFTWEMFKQVPATNPTCEDRPYNASMCGFNNFYGCIPLDGCGNSLILPFMYLFFLIMGYIGINLFSGIVVDAIGDASSDCPVNVNTLAEFSDRWAQFDPSGSGLITAEELTDFLYTVYPPFGFKGVPGFTRRRVVIAIGELDIPIYDKQFVHFKDVPRALVQRVLAEGDKTKYAEISSVMERLGINRQFDEMWFRNHGKKHQNNLTQRDKRPAKEYSATLVIQRFFEKVKLERKRRRSVIIGTTDGLHSNPQSPAKSTNARDMDVESVEVPDRPPDGDHIPPDETIGDSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WB10</accession>
    <name>A0A6G0WB10_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_016855</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000270">
        <property type="protein sequence ID" value="KAF0724448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WB10"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000366"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="100"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="315"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0724448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="367" mass="42416" checksum="224E0789A7319EEF" modified="2020-08-12" version="1">MAMTDSFPLLIVDLLKEKEPYFVDVSILEEELEGLTVKQLEAKLAQAVELQGLSKGLLLYGQRLREDKRVKSYIPSLQISNGARWMLEYTSRSCDREEARQIYVRTLTGKTLDLKVTSYSTIENIKWKIYKMEGILPEEQRLRFGQRELKDARTIADYNIQNEDMLLLVLRMRGGGGLFADIEDSSQVQQVNIVAEGPEWRVISEGLNIEGKCLNRNCGAFQKLVIIKNKMEQFNLLIDSMSCPMCNAQVTPITCGFYRCQWRFEGVKSQSMKEVRSPWYIAEGEKYHRFNSEESKLIEWASLSIIPMRIDRNACDYCHKGFDSGHKQTLRCNHEVHSKCLEAWTIHCLRNKKPVKCPKCHTVIKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WB75</accession>
    <name>A0A6G0WB75_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_017338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000294">
        <property type="protein sequence ID" value="KAF0723843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WB75"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003813"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="598"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="630"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0723843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="667" mass="74251" checksum="9C3A063FC7B081A1" modified="2020-08-12" version="1">MAYVQALRNFVTESLDGVDTAGLSQICSLFHLDASTLPSKPDVVRSIIDLVVMDRDTALGLFVAWKQAITSPGAPAIVLDNANFANAFLPTIASSPRKQIVPPTTPKTMFDFVLDRELTVIANEVKIVETAYKEAERGLHQGEISYDKIKRFLQTLTKLRAKDDQFRILLLEKNQNLQADNARLYKLEAHTRQQLEFFVDGCARLRTKHDAIIEEFSQHTAIEASAHDFVLQLYGGELAFTLALTATLHFKCARLCETQEALQQAHDTISDLRATLDQKNEMLQVIHAKWDAAAKDATCARLQLRKCRKRLREADQLASDCSLLRHRVYSLQKMACDLLGLTQVQTVALNDAKGPFVKSIEHNSIAWRVLTYLTTLGTPSMSLSRQGLAPFPELKHPPKHRHDLSHDLPALVFVGADTELHREAIHHFSHRFGYHTFDVDAWRSVVSTPESALDDIPFEQLARTIQSSFPVVLHSWTNLQPQDIHRLVQHGVDATAVVDLDGSSAILAQLGTYRPLLQAASTTSTLSVDQIVHEADALVQSMQDKQYNQVHLHWDADLTVLNERCAMMAEEMNGRMAVEWKKYLELMAEKKAEKLAKLNKAAAASSNQKDKPRTPAKGKNPPAKPATRQAASPAKSPKPGSKPSSPAKTTSSQDKARRTTSVGLEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WBD1</accession>
    <name>A0A6G0WBD1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_016783</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000267">
        <property type="protein sequence ID" value="KAF0724576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WBD1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015764"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="23"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="198"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0724576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="370" mass="41320" checksum="4B5F7AEA4D50F2B3" modified="2020-08-12" version="1">MEVILGPETGKSTTPVELGMATMAIGRSKKFVCGKANAPGLLLTLDLDVSSRHAQIEWNPRCAKICIQDCKSTNGTKVNDNLLPSMEPWPLTDCDTIGAGCSLIVYRVQSKCPQCENRSTKPVSPPQAIIFDEPQQNCVVCGDSLMGLGEMDRHAHVNQCLDVKKGAKKSSFGKQQIDLAVAMSRSIVDEHIENNVTKGLLERQILDIDAQIEKLQKKREKLVRALQKTERQSRKLVTSQILPPQAVVEWSVEAQLARLFPESKRQTRQPKTTAKSSALWTKSSTGPAADDSVYLVPCFHQYEQVPRYVSETFPEWRENLEFISLSSRSSLEAALDRLVAAKATLDRLDPKWLAFSFFEKRMRYLLDNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WBW3</accession>
    <name>A0A6G0WBW3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_016739</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000266">
        <property type="protein sequence ID" value="KAF0724676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WBW3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001943"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF489">
        <property type="entry name" value="RING FINGER DOMAIN AND KELCH REPEAT-CONTAINING PROTEIN DDB_G0271372"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00501">
        <property type="entry name" value="KELCHREPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0724676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="39534" checksum="197D5FAABEC97650" modified="2020-08-12" version="1">METNQSNMPPKKVRKIEGADEEAAAAPPASLSCNVCGDTSFTSRNQLFRHLKDCASNQIFRKVNSELVKPPASLSNLYYYVTGGRLRGRTLGSVERYSLERNCWEAAPSMIENRGSHGAVGVGNQLYILGGGGFRSNLATCEKLEGGEWKAIAPMTTYRHALAVVHMDDSIYCVGGWVNGSKCSGVLEKYDMKADTWTTCKPMEEPRRLLGATAFNGKLYVFGGNADDHEDTDKKWYSNTVECYDPSTDSWTRKSSLPTPGPCSAVTVGAYIFVFLHGKSVLRYDPAMDVFTVVGSLPLPEWYCFDAKACGHTVFVNGGIAKGVWSKAFYKYETLENTWTELPSMHTARRRCAAALVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WC71</accession>
    <name>A0A6G0WC71_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cellulose 1,4-beta-cellobiosidase (non-reducing end)</fullName>
            <ecNumber evidence="3">3.2.1.91</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_016554</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains.</text>
            <dbReference type="EC" id="3.2.1.91"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 7 (cellulase C) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.91" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000260">
        <property type="protein sequence ID" value="KAF0724861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WC71"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014421"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016162">
        <property type="term" value="F:cellulose 1,4-beta-cellobiosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.100.10">
        <property type="entry name" value="Glycoside hydrolase, family 7, domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001722">
        <property type="entry name" value="Glyco_hydro_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037019">
        <property type="entry name" value="Glyco_hydro_7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753">
        <property type="entry name" value="1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753:SF2">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00840">
        <property type="entry name" value="Glyco_hydro_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00734">
        <property type="entry name" value="GLHYDRLASE7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026159139" description="cellulose 1,4-beta-cellobiosidase (non-reducing end)" evidence="10">
        <location>
            <begin position="20"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0724861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="380" mass="41280" checksum="CB118F55493A8A48" modified="2020-08-12" version="1">MKIATAIAYLAAMVAFSNAQQVGTLTPEIHPSLPSQTCTASGCTTQNTKIVLDSNWRWLHNVGGSTNCYTGNTWNSNYCPDPATFAANCAVDGADYSGTYGIAASGNGVSIKLVTKGPYSINIGSRIYLLEDDNTYKIYKLLNQEFTFDVDKWTRMVASPSMASPSKTNKAGAAYGTGYCDAQCPHDIKFINGEANVKNWVPSSVDPNAGFGQYGTCCTELDIWESNSISQAYTTHPCTVKGQTRCSSPTECGDDDTGNRYTGVCDKDGCDFNPYRYNSHNFYGPGSSFSVDSTKPVTAVTQFITDDNTANGNLVQVKRFYVQNGVAIDNAPISWSGIDPLNYLTDPVCDQAKTLFGDKNDHKPRAGSRRWVTLSREVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WCZ3</accession>
    <name>A0A6G0WCZ3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_016574</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000261">
        <property type="protein sequence ID" value="KAF0724825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WCZ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013413"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF59">
        <property type="entry name" value="UNC93-LIKE PROTEIN C922.05C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="406"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0724825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="453" mass="50523" checksum="25D06FADFD012E4F" modified="2020-08-12" version="1">MFWRNPTALAQVILVSVVCFTCPGLFNALTNIAAGVADPTITYNGSAILYAFFAVFGFFGGGVVNIIGPKWTLFIGTWGYVLYSLSLLFMDENYDKETNQYASLAKLYFYIANALLGIGAGFLWTAQGQMCMAYPTQETKGTYFAYFWVIFNLGGTLGGFMAFGTNYDLSTDGASASTLTYIIFLILMSCGALLSLFLANPENVVRNDGSRVLVARLPSPTQEILATARVFVDPKMLLLFPLFAYSNWFYSYHSFFNTAFFNTRSASLSSAFYWAAQMLGAYTVGIFLDRPGPKKFKALRSILIIGASVMVMWGAACWLQLDFDLSNDEGKQKNIDFQEARFYPKWLLYMYFGFNDAVVQVWSYWLMGQLSDDLGTLGRYSGYYKCVQSGMAAVAWRLNGIPVSGIASLTVSWAIAALGMVGAYISVYNYLADVPRDRYDEFDMLDEIAKDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WEF5</accession>
    <name>A0A6G0WEF5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_015843</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000233">
        <property type="protein sequence ID" value="KAF0725756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WEF5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005768"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF317">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="348"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="473"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="3">
        <location>
            <begin position="43"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0725756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="565" mass="62009" checksum="70412F333717FB00" modified="2020-08-12" version="1">MFSRLGQYWRVTVPPKTQHELEAERWLFVIDLRRNRFRFSSGLLFQRWALALLTLFTQAAIGSLYSFNTLAPYLDTYFGGSTNSIQIYLISTLSLGLAGAVSGPFLERNGPRTSMMLGSVVFCVGLFLSQIAVAVKSLAVLYIGFGVLTGIGHGVLLISSMSTLLKWFPDWRGLVTGVCVAGMGLGTAICNILYSHLLESSPSKLNVAGALGYLFVLTGVISLIILFLSVMVLRTPPPNFAVNGHDIHNIPLSAAPSPTRVQDEFLNVGMTLVNYAALEPRHTMLSTDKEYFQQVKALTLVQCIFSTDFLWLFIIFAANLAPTVLFLPQVNDAITIVLHKSLEDASELLSRITLTTPIGVLVAPVLSDVVIRIFYANPAFARKMIFFVMVAMQAIVLGFLIRTWTDLYSWAWYGVVICVGGGFGVIPSLVCDMFGVYNAGTMYGLIMASRSIGAVVVGFILPSMSHTEKSIHIQLVAMFAFAAVAAVMMIFVRTNTMDRFFHGYQLTLFNKVVIQVPFRTSTAGSNLVKRRQITAATAAPNDAFFLMSPPRMSDMSILSPDSQEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WG35</accession>
    <name>A0A6G0WG35_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">riboflavin kinase</fullName>
            <ecNumber evidence="2">2.7.1.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_015925</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.26" evidence="2"/>
    <dbReference type="EMBL" id="VJMJ01000237">
        <property type="protein sequence ID" value="KAF0725592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WG35"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005627"/>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00406"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.30:FF:000005">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase domain-containing protein 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="entry name" value="Riboflavin kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023468">
        <property type="entry name" value="Riboflavin_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015865">
        <property type="entry name" value="Riboflavin_kinase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749:SF6">
        <property type="entry name" value="RIBOFLAVIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749">
        <property type="entry name" value="RIBOFLAVIN KINASE/FMN ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01687">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00904">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="Riboflavin kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Riboflavin kinase" evidence="8">
        <location>
            <begin position="4"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0725592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="151" mass="16756" checksum="387BBEE004D485ED" modified="2020-08-12" version="1">MKEIAPIRLSATVVAGFGRGGKQLGCPTANLSADDLGKLLHDIPTGIYCGWATVDGQGPYKAVASVGWNPFFQNKEKTIEPHLLHEFISDFYGAKLNLVLFGYLRPEENFPSLEALIDAIQNDIKLSREWLDEPKPQTFKRDELLRVTAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WGA8</accession>
    <name>A0A6G0WGA8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_015819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000232">
        <property type="protein sequence ID" value="KAF0725857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WGA8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019404"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF44">
        <property type="entry name" value="PROTEIN AIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="36"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0725857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="249" mass="27347" checksum="AC9E9A5B25ACEA7D" modified="2020-08-12" version="1">MSCCPADGLPAAPTTSPLVPENIEGTDIFYFDNPNSHVAVLAFPDVYGPDSGRTKQLCADLSKHYKVALVDICDGDYRTATSDRSQFATWAQERPFEKLKVKIDAIIKHLQTERGVTKFGAMGFCYGAWIVARLSAEPSSVLSAGISFHPSWHANDVFHGEGSAEKIAHDIQVPQSVLTAGNDRDWLKPGGSVEQTLQAKGVPSRFREFPNMVHGWVIRGDLADQGILKGFHDAWVDEALPFLKEHLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WGP5</accession>
    <name>A0A6G0WGP5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_015433</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000219">
        <property type="protein sequence ID" value="KAF0726318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WGP5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004649"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="231"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="491"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0726318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="695" mass="76445" checksum="18BF8E5FA89CFCD9" modified="2020-08-12" version="1">MEVEVQAARRHEYHSSDVLISPEMLAVASILPGSYVALASDTQVWLRRTMIDPELPTHVVSGRFHLQKSPQDTRLMMYPLANRYIPTVEYIHLEMFESSACRYGDQKIPPQPSISMLVGAIIQDGMLWHCVWYGVDYGAWRCRLGSMPDVRSMFEQIPTTIQNQLGRFGAISSTTRLTVSHDRSCTFRIETPAFTTSFVPNRTSQTLNEMASIHLMASSNEAVLSSSTPTGICSILIYGPVSSGKSALVQDLARRNQATLLKMDASIISLQTGAPLEQHFLDCFSAALHMQPAVIFIDNLELLFPKSHQGPGSDRLSDFCSAMIALCNEAQQARVVVVGTVVEMDHLHPKVRQCFTDELAMETTALPFRRELLMSLFSSSKENSSPSKQAIDALLVQGGQLPGDITSIVRQAVTSLVVEDGKGSSPTMSLENVVAAATSSARQSKRSSVVTTPSVTWNDIGGAEELKQYLKEMVVWPFEKPDVLARMGISPPVGLLLHGPPGTGKTMLAKAAANATMCNFMNVTASDLMSSEFGESEKAVTQMFQTAKAMSPCIVFLDEFQSLFATRSSSSIGSRMASQLLQEIDALKTLSSSEQYVFILAATNCRFEHILYVGYPDAAGRLKILKLMQSQMPWDSDVDLEDLVQDMDGLSSAEIVSVIRIAALISLERNETKISMDDLRQALIQTLERYHVVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WIZ5</accession>
    <name>A0A6G0WIZ5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_014730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000200">
        <property type="protein sequence ID" value="KAF0727201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WIZ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000115"/>
    <dbReference type="OrthoDB" id="69907at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="36"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0727201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="144" mass="16879" checksum="E23E3D142D09D209" modified="2020-08-12" version="1">MIDIEQAATVSILYDALLHKKSLYCHTKMIEESKKLMACKKDIEECQERIEEIDEQLYDIQVECLDQGIDAFDTNAEAQALRAEKEEEETLLKQMHSVLECRKRSMRMFIKHKAVLDNSRKSLKNRQRRIVEKAFRTGLLVCQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJ40</accession>
    <name>A0A6G0WJ40_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">YncI copper-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_014747</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000200">
        <property type="protein sequence ID" value="KAF0727219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJ40"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000132"/>
    <dbReference type="OrthoDB" id="4234at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08545">
        <property type="entry name" value="YcnI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2230">
        <property type="entry name" value="Uncharacterised protein YcnI-like PF07987, DUF1775"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012533">
        <property type="entry name" value="YcnI-copper_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038507">
        <property type="entry name" value="YcnI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07987">
        <property type="entry name" value="DUF1775"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026105795" description="YncI copper-binding domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="YncI copper-binding" evidence="3">
        <location>
            <begin position="20"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0727219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="207" mass="21562" checksum="C4D048476DB76858" modified="2020-08-12" version="1">MHASALFAVVAALATTVSGHVECNPPVAKPNGYFVTAFRVPHSYPGAKTTNVSVSIPDGVASVKPRQIGGWDVAFETKKVNGTDAISKVTWYGGSLPNELYQDFGIQMKIPDLPIGTILYFPVTQNTDPNGTIAWTSIPDASGKLADASHPAPKVTLVNSTDSDDHDHSSNSTNSTKAPNATTVAPTKSSAVAVTTSVAVALLALFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJP6</accession>
    <name>A0A6G0WJP6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_014469</name>
        <name evidence="1" type="ORF">Ae201684_014472</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000194">
        <property type="protein sequence ID" value="KAF0727450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VJMJ01000193">
        <property type="protein sequence ID" value="KAF0727644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJP6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021634"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43102:SF2">
        <property type="entry name" value="GAF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43102">
        <property type="entry name" value="SLR1143 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0727450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0727644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="170" mass="19182" checksum="3C7EDA06444AD1A0" modified="2020-08-12" version="1">MVNADFEEICRSAMQALDCPMAGIRTNLFELVHYVEHVNPSEMPKSLPTFRRMAQSGKPCVVLDVNSDKRISVDRRQTSRIQFFVGVPLTLENGDCIGDICVADTKPRKVIDYNALEILKVLAQSATQYMSAAEYLAENTHLPRDMDIDGSDQQPAAQYTYNSDIREDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WK03</accession>
    <name>A0A6G0WK03_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein SERAC1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Serine active site-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ae201684_014398</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the SERAC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000193">
        <property type="protein sequence ID" value="KAF0727570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WK03"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009737"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF0727570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="906" mass="98574" checksum="3371A58092439583" modified="2020-08-12" version="1">MMLRLRSGRRLASRSVRRLSTTASQAPKQPRSLQWVGVGAATVGIGAASAYSIVGSNEDYKRSANAVISLGRVLTDVHGAKEALSAATDIATSSNVEERATSILAAIANDQVFRKSLVDRGGLDVFMDTCKHTSEPKLQERIVHAIAELANTPGADEVFLDIEKSSYLALQMTSTIVHRQPHDPKPVAITPLDAMQLYATFSRIRQACAKNTAQPIFRKGTSEAIFDRLGKVVTGVSTPELKLFSLWAIHALLEHLEATDPTTFQASGSHLNFHLSNKLFNLSTKETNPQLKLHAAKLLTIMLRNTLHPVAPKYWCQEVAKWARDPSPEMQLLSAECLHVLAKKVPDDVLKSSAAQDALLHMARLHRQAGPSSVALQLEVSNAVHALADVLQTSLHTTVEAPMSKLFEHLDDLPVLDAKEYDALPEFGWVDVLSEWALSANPSVCANAIQSLSHLALRESTGHHFVLQAWMMSLLRQLGHAKSINAQSRRAVAEVESLANMTQDQTPGQLHVAYSPLVMETGLGALAVLVDEPQLADMFTTHGGLELVALAAIKSTAAVKSQCARILANLAITRPSVARQVQDVLGGALFTQELLHWSEEPNVMVRSNYFRAATNFASTAGQKEEDRVIYREGVHPIVGRIPSHATHSPPVDVVFIHGLRGHPFGTWRTDMVSGDMERRAYVIWPEAFLLHDLSPESRLVTLGYDAGMVTWSSPWPALTLEERAKLMLKGLEAAQIGTHDRPVVFVTHSLGGLLAKEMLVVAAQQGKPLVENTAGVVFMAVPHFGANLSSLNNDTLRALVQAHPATKDLNVNSSRLLALHTAFQNLKIPSLSLAEGRPAPLGLGVNHMIVMPESADPRGGEGSAFHLLLHAHHMDICKPPTKKDSRYSLVRDFIATCIAGKDNSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WKD3</accession>
    <name>A0A6G0WKD3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_014321</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000191">
        <property type="protein sequence ID" value="KAF0727696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WKD3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009170"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004798">
        <property type="entry name" value="CAX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00846">
        <property type="entry name" value="caca2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00378">
        <property type="entry name" value="cax"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF22">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0050">Antiport</keyword>
    <keyword evidence="5 9" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 9" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="304"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="334"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="90"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="269"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0727696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="416" mass="44676" checksum="D6C3180A25FAB7F9" modified="2020-08-12" version="1">MIKRTASLFLRKGTAEETDETTKLLKQASKKASVEVDPATVEATPGKRDPTKPLGQALWDILVGSYVNLMLVFTPFAIWSYYAKWGDIPVFVFNFLTMMPLASILGDATEALAYHTGDMIGGLVNATFGNAVEVIIAIFALKSGEVALVQSSLIGSMLSNMLLVLGSCFIAGHIGGAQVSEFSAEGASVNMSLLFVSSFAMLVPSYYHYSQGTPSAETNAAVLGLSHISALFLILMYLLLMLYQLVTHRPAEVEKDEDEEEPELSFYGSLFVLLLMTVLVSIFSEFLVSSVDGFTESANIPKPFVGIVLLPIVGNAVEHITAIKVALKNNMELALGVAVGSATQIALFVVPVCVVAGWLLDQPMTLAFNAFEAITYVVSSVVVYVVVADGKSNWLEGALLIVLYCLVGVALLYINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WL61</accession>
    <name>A0A6G0WL61_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine aminopeptidase S33 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_014105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000184">
        <property type="protein sequence ID" value="KAF0727999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WL61"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007676"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051044">
        <property type="entry name" value="MAG_DAG_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11614">
        <property type="entry name" value="PHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="1">
        <location>
            <begin position="34"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0727999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="288" mass="32279" checksum="03CF7C8B3C08DDDF" modified="2020-08-12" version="1">MGDSFTLMEGSFASGRGIKLYTRKYIPASSYSVVFLFLHGVGEHCTRFHDTFSTITKQGIAVYALDHQGHGKSEGARFDCRSFEEFTDDIFTYNDIIRRENASNPQVKYVVAGFSLGGLLAVYVAALKPDLWDGIVLHAPALGLDKSWLMQFQGLFAPILEFLVPTWEVVRAINLEYASRNKAYIEDLLNDSMMNHNPLRVRLIRSIERGMKKLKKIQNNVKMPVQIFHGDADKLTSPISSKQLFDAIPSTHKTFASLPGQYHCILDEPEAAATLVATIDWLKAISKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WMT9</accession>
    <name>A0A6G0WMT9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_013625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000175">
        <property type="protein sequence ID" value="KAF0728667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WMT9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014924"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0728667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="138" mass="15072" checksum="1B733092A1666585" modified="2020-08-12" version="1">MSCLGAFGAFLVLVDVSHNNWDFNHFLGNAQYFITPVANLPSLHAIKSYYAFPNEASPEDLSEVAVFMMNHSLSTAVDHDGSHYLITAGSYAILDAANDICGDLVHTYPLRNVADSLSGTIRLATVSDKLEYVRGNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WN89</accession>
    <name>A0A6G0WN89_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ae201684_013366</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000172">
        <property type="protein sequence ID" value="KAF0728794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021798"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000997">
        <property type="entry name" value="Multidrug resistance-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000074">
        <property type="entry name" value="Multidrug resistance-associated protein 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="715"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="751"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="825"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="852"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="942"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="102"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="424"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="719"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1036"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="653"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="663"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF0728794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1283" mass="139211" checksum="838F92AF96093E53" modified="2020-08-12" version="1">MSKSANDSEATYQGLASPTTASASSWRDKPMPIATTNWLSWTLLLWFDPLVWKGARQQLEESDVWHLPPADTAAALHSRFESVQSSSCFRAIVRTFQREITIVLALYAVSAVLTLAQPIVIKSFLQFLHAPRHDDIHTDLGISSGYVLAALLTAFSCAAVTLMDLGMVLAGKLGCNAKTLAMDLVFRKSLRLSENAKRTTSSGDIVTLASVDSTRLFMCGLWFMWTFISPVMLVAIFILLGFDLGALPALLGGVLMIGLLYFGCREASAVGIVQKELLGVQGQRVKLTNELLQGVRAVKLYGWEQDLLAHVEELRVAELQLLRVYHSRRQVSSIALLLAPVVSLALTLAVYVAQGNSLSPPLAFITLAYVNAARVPCSSFSFSIMNLVDALHSCSRLDAFFALDEVTTPLLLDNGVHADMAPCVELMDASFSWHKDDSTAACDLRGITLQLKPKSLTMVVGSVGSGKSTLLSAIMGELHHIQGERGVRGRFSYVGQDVWIQNASLRDNILFTSAFDESLYHRVVAACQLTPDLAAWPGGDATEIGERGVNLSGGQRARVALARSLYSNAADIYILDDPLSALDVHVAGHVFRDGIQALLHDKIVLVAINSHYHLLPMADTILVMEQGRLVAQGPLSSLLDRFPHLGVDRIDEKQPTTAQVETTNDDDDDVAPPDEGGEGGSAAVSTLVQAEERVVGKITAATYTTYFAASGWNGFSVALTVVIAFALAQASLVVLDWILGYWASTADPSNAAFAAIYVAVAVVAVGLVLGRSLYVLHFILLCSKHLHETLLAKVVYAPVPSFFDVTPVGRILNRFSSDLSQVDNMVPMLGLHIFGLVFQIVAALVVCAVTSPFILLVYVPLAVVFVKIRAIYSATATALKRMESVTRSPVLNLLTEAMQGAPTIRAFDHAADVQALYRRAVDYNMSFDMTHFISTKWFQMRLDWLSVLVVCGVAFLAIETKSWMGVTAAGLALTYAMQLTIVLSRTTMEFTYMENVMTSAERLDHYQSLAKEGHDDVLSLAQQQTCPQGWPRQGHVVFEHYSMRYRDNLDLALHDVSFAVMAGEKIGICGRTGSGKSSLLAALFRTVEAASGCICIDGVDIATVDLHTLRSRLTIIPQDPVLFSGSLRFNLDPSMKTSDAALWQALKQVHLVDLVQEGQAAGLEFPIAEHGSNLSVGERQLLCMARALLRQSRVVVFDEATASIDGESDRLIQATIQKNFRGGGVTLLVIAHRLETILDSDRILVMDQGRVCEFDTPATLMAANEGSGGGGGMLAKLVEATKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WNF1</accession>
    <name>A0A6G0WNF1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_013454</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000172">
        <property type="protein sequence ID" value="KAF0728885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WNF1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014809"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0728885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="103" mass="11596" checksum="453E8A930134BF89" modified="2020-08-12" version="1">MSQLEFNVKSWSQADLDPYVEGIKNIFAKGLDGKSDSVRVKARDILSLLRDMRHKTFNISQVKSYLSSEFGLGAGRTDSENPQQALVPRITKQRQNVSCLLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WP57</accession>
    <name>A0A6G0WP57_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_013139</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000167">
        <property type="protein sequence ID" value="KAF0729161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WP57"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011576"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641:SF19">
        <property type="entry name" value="NEPHROCYSTIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="382"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0729161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="493" mass="56067" checksum="E245E317CA625072" modified="2020-08-12" version="1">MESSPPPLGLTLAFFHEFIRRSKIPLEGLTTKDVCRELVKPYTLSTKQSLVNHVLADPVDSITYLRPASWYVSHAWSYLFLDTVQALDTYFDEKELDPSTEALWFCVFNVNQHDVVSDDAVDFEEIFRTTLGTIRRMVMVVHPWNDPITLTRIWCIYEVYLATLLEGGEFQVAMATPQKRAFLDDVRSQSNAFFDMLGKVRSERARATKRSDQARIVQLIDEQIGFTDLDNKIFGALSGWMFNCVLQQSVLPNTTLVESATWCLVVGALMCDADREEEAEKYLLRALDLFQDNIAACKASMYIARVRAGRGEPRINWENLLIASMKRQSYELGRAHPDTLNTMYELGFCYCDIGEFDQAAELLTEVVIHRTNELGEGHYDTTIAMSLLGYIYLESGELDEALKWLQPSYDLQLTHLGDDHPATGRTMNNLALCYDGQGRYDLALPLYRKAHETSRRVFGEKHPSTEASWDNLHAATLRSRLLDSTSLSNSDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WPI1</accession>
    <name>A0A6G0WPI1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ae201684_013002</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="VJMJ01000166">
        <property type="protein sequence ID" value="KAF0729252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WPI1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015002"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000315">
        <property type="entry name" value="Calcium-dependent protein kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="28"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF0729252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="340" mass="38156" checksum="5A7FC37288F90878" modified="2020-08-12" version="1">MAATKEEKFAALIAECTLFEPCLSKEHYDMGRVIGRGSFSVVRVAVHKETKTKVAAKCIRKANLSIVDVQAFITEVSVLKEMDHPNIIKLYEVYSEPDQFILITEFVEGGELFDRIVDKTCYTEREARDVVKSLLQVTAYFHAANIVHRDLKPENILLVHREDDAVFKLADFGFAKRIDVSQDGLVTQCGTPGYVAPEVLRGTSYGTGVDIWSIGVITYILLCGYPPFHNENRNLLFQAVKKGEFTFHSPYWDEISETAKSFIRAMLTVDASKRPSAVVLLEHEWITGRNVGTVQLSDALKQLRQFNAHRRFKAASIAVMTSNAFKRSSSKEIPEAAPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WQ36</accession>
    <name>A0A6G0WQ36_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutaredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_012971</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000164">
        <property type="protein sequence ID" value="KAF0729473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WQ36"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010014"/>
    <dbReference type="OrthoDB" id="44061at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015038">
        <property type="term" value="F:glutathione disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03419">
        <property type="entry name" value="GRX_GRXh_1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000093">
        <property type="entry name" value="Glutaredoxin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011767">
        <property type="entry name" value="GLR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011899">
        <property type="entry name" value="Glutaredoxin_euk/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02180">
        <property type="entry name" value="GRX_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694:SF5">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00195">
        <property type="entry name" value="GLUTAREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="5">
        <location>
            <begin position="14"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0729473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="101" mass="10627" checksum="87B7A5602FCFF180" modified="2020-08-12" version="1">MADVVASTLASNPVVVFSKTYCPYCVLAKKVLTSVNAKYEVVEIDNLPNGDDIFYALVSKTGCETVPQVFIGGNFIGGGSDTDALQKQGKLVPLLQEAGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WQF6</accession>
    <name>A0A6G0WQF6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">phosphoethanolamine N-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.103</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_012873</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N,N-dimethylethanolamine phosphate + S-adenosyl-L-methionine = phosphocholine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25325"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58641"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
            <dbReference type="EC" id="2.1.1.103"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:25326"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-methylethanolamine phosphate + S-adenosyl-L-methionine = N,N-dimethylethanolamine phosphate + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25321"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57781"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58641"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.103"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:25322"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>phosphoethanolamine + S-adenosyl-L-methionine = N-methylethanolamine phosphate + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20365"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57781"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58190"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.103"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:20366"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; phosphatidylcholine biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.103" evidence="5"/>
    <dbReference type="EMBL" id="VJMJ01000163">
        <property type="protein sequence ID" value="KAF0729608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WQF6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005871"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000234">
        <property type="term" value="F:phosphoethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44307">
        <property type="entry name" value="PHOSPHOETHANOLAMINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44307:SF2">
        <property type="entry name" value="PHOSPHOETHANOLAMINE METHYLTRANSFERASE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="9">
        <location>
            <begin position="57"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase" evidence="10">
        <location>
            <begin position="280"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0729608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="492" mass="55753" checksum="7D6A2EB5F8511FBF" modified="2020-08-12" version="1">MEGKAEETRANMKAYWIEHSMDSSVETMMLDTNAKILTELETPEILSKMPSYKDKDVLELASGIGRYTGTIAQHASSVVAVEFIEGFHNTNVELNGHNSNVEFICGDVCDLERQPKSFDVIFSNWLLMYLNDVEVKKLAMKKLHWLRTGGEVFFRESCFRQSGDVKRTTNPTQYRHPSFYMEAFSSICIDEGNGLISQFELVSQSSVSVYRRVKKNNGQICFRFRKVTKAGSAESFQRFLDSQQYSTGSISRYEKIFGEGYVSTGGQETTTEFVAKLNLTEGERVLDVGCGIGGGDFYMAKQFGVSVVGIDLSTNMVHRALERSLAEPNVDCEFEVCDATTKEYPAESFDVVYSRDTILHIQDKKALFEKFFRWLKPGGRLLISDYCCGEQEQSDRFKAYVKSRGYHLLSPAQYGDVIACAGFQTVHAEDRTEHFVQVLQTELDRTLLNQDEFIAQTSTKDFEDIVDGWKAKLVRCADGDQKWGLFLAHKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WR18</accession>
    <name>A0A6G0WR18_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_012513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000159">
        <property type="protein sequence ID" value="KAF0729869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WR18"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007263"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22538">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22538:SF1">
        <property type="entry name" value="VWFD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0729869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="558" mass="59219" checksum="DB649268BFA3AEE4" modified="2020-08-12" version="1">MDSPSDRNRAMTLTPSLFDSLESPNTKAQAQAQRSRRFRIGVLVAALLGVACVAIGAVVVFRQKSHNSSATLLAAAQATPAIKLTLQFKRESMYYYGQSSAVVYAFPRTSSSGANLGYDGVLELKQGTTIEKQQTTAASCLTASQMPTFNVVDSTLHNAKVIDRATVGSTTLEATTDCPQGKLLSVAFGGEKFIVCTAGDDKVKQITGQDMNIDVEYLSSLAGVPSLDVPKALDGSVLSCQTIAPKSVATVETKSFSEVTTAFTETLLGTRQESLFGSDCQCKARKPCLFVHGVFNFIEGPLSDTFPLYWGDVHKHVPCCSSIKFVHFDTINQGWNDDSIQNSLCKAALQVSGSSTKTVGPLNLITHSMGNMITGAALATGKCSLSKDVTWISSAGPMKGSESANLLAEKCLGGGLDVIISVPLEFLGFCPPTRAFASLYYQDSVNAATQKLLVASAKARANHPNKKVLCGTSAYGINSIFSIPLQIIGSWSEHNGAHDGLVAVESCVAGLGNNFGFGGDITSTNYKGPLNHEDLAFRNGDGWLGDDRKPVKWLSCAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WRX2</accession>
    <name>A0A6G0WRX2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_012207</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000155">
        <property type="protein sequence ID" value="KAF0730203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WRX2"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0730203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="95" mass="10579" checksum="5CB1A8CCF7B4AF0E" modified="2020-08-12" version="1">MAGIESSRLAMGASCVWHVGLASSVGHNRCRQLKSGSSMSTIVNFDTYTGHTRIPCDQLNREVLIPSTSLVSIRGILHQEEPLFILCQWRRSSYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WSC7</accession>
    <name>A0A6G0WSC7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_012328</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000155">
        <property type="protein sequence ID" value="KAF0730330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WSC7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012541"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004484">
        <property type="term" value="F:mRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000256">
        <property type="entry name" value="mRNA capping enzyme, C-terminal domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051029">
        <property type="entry name" value="mRNA_Capping_Enz/RNA_Phosphat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367:SF17">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="5">
        <location>
            <begin position="119"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="4">
        <location>
            <begin position="271"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="5">
        <location>
            <begin position="346"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="5">
        <location>
            <begin position="543"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="229"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="620"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="627"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="678"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="723"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0730330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="740" mass="86637" checksum="74ED482E2341814D" modified="2020-08-12" version="1">MAPTSKRDKDAWEPPDHWDDVDRLGGFIPMGASEDTRGKLVAARVPLDRKYVLPEERAWSPKHLLESCRERNMNVHLVIDLTNTFKYYNGKAEFEPYGIEYVKMRVEGFADVPNEDIVHRFIDVMSKWEKTLQEASDDDEDSTSLTPVAIVHCTHGLNRTGYLIVRYLIAIKGLTVKEALDVFSAARPPGLIKHMYIRTLYEMFNQTADMVLPELPEWAQNKYDRSKEALRTDDKFRDSKRQRVNETKRKPPENWSRPPRMGNIVVDSPFLPMRTPLNKSFDHGNDPWTPEIFATEQTLQGHRVKLVVDLTNTKKYYDGPSCFPDWEYKKFPLDGFHGAPSRNCVNKFLDLVKDFESTHPDGHLALHCTHGLNRTGFLVACYLIQRKNYSVQAAVDAFTDARPPGIIKHAYIDELFRRYANAADARIVYPVLPGWAMKKYGKRDLNLLPPPAHWLEREPHGKWIKSETVHFMPIKTMLDERYASDGSWDVDDFNEWLASEEEPVHGIINLNESGVYYRNDKLSPDIKTMHLVHKAVPNIADQNQFYETLAEWQDGVRGAPLRVVIHCTAGSRAGYFIALYLFEITRLSVDEALEAFQKSWPPGHVQKPLTKNLYFFERKKRQNTDTQIDHAAKPSQDRPRERNNERQRDRSRDRPRGRGNERSRERDNERPHHRHERRSQELSRERPRDQNSSRERTRDQNRAHPRDRSRERHHDRSQERQSKQNKNRRARRRPPYRPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WTX6</accession>
    <name>A0A6G0WTX6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase C1A papain C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_011777</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000149">
        <property type="protein sequence ID" value="KAF0730895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WTX6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014307"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026156620" description="Peptidase C1A papain C-terminal domain-containing protein" evidence="4">
        <location>
            <begin position="18"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="6">
        <location>
            <begin position="137"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="5">
        <location>
            <begin position="496"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="351"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="407"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="451"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0730895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="649" mass="68329" checksum="2951B815333F5281" modified="2020-08-12" version="1">MKTSLLFLPTLSTSALARVAYSSLGVDEQADVKQQLAKWKTLYAPLATKHGFVPETGIESVSVVDSHTDEELARFHNTLQDVATAQKNNPHAVFSPFNVFALLTPAEFSKIFQNSFVARNVSAGQPLRALESTVSAGGGSIDWSTSTCSSPVKDQGDCGDCWAFSAVGTAEFAHCIATGENLDLSEQQVASCDTASSGCNGGYPSAAIDYQHNGGICLESAYPYTSGTTGQTGSCQSSCTKKTLSIGETVQTEGEDPLVAALNKQPVSVVVEAGNEVWRNYKSGVVTQCPGKQSDHAVIAVGYGTSTHDYFKIKNSWGAQWGDSGYIYLQRGVGGKGMCNVVEGISFPMLTGTSPTTAPPSPSTDEPTALPTSSPTPKPPSTTATRSPTVGPTTTKSPKTQKPPKTKTPTRTTGSPETFAPTDSPATPAPSTSLPSPTTIPTTPPSKKRTTTPATTLPVAPKTASPTTRVPITTSTPTKKPTTTTTTPAPGSSGTGIQGQLIMQTNKIRAAHGLGPVTWDAALAADMQKFADSCPGFNHGGPEGWQNLATFEPCSGDACLKIVGAAWLWYNEEETKWNYNANKCNGDWSVCGHFSNMMAPGVTQIACGWSQCSKGNSYVWCNYESSEMNPVVPRIRGMTKQQLLASLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WWW9</accession>
    <name>A0A6G0WWW9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_010684</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000137">
        <property type="protein sequence ID" value="KAF0732031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WWW9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006343"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051191">
        <property type="entry name" value="DCAF12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19860">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19860:SF40">
        <property type="entry name" value="WD40 REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="390"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="736"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="407"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0732031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="927" mass="105115" checksum="09C875FE04E4B092" modified="2020-08-12" version="1">MTAGATSPKRAKKDDKPGAITLPKELRSGDDAQRVESATLMRESGAHEAFARSRMDGFVYVETPSYMHVLDAHCRFELESETSPLLVVLGHPASGKSSLLINWVNQRVKKQPPAANPEVIFQHYCGCSYESVKLSVFLFRLMYHLKAAFSLRDFELPHEHEEEKLKFSLARCFEGAMRSTTQNGKRKNIIIVLDGVDNLRTEDGSESLSWLPNALPPGRSFHSLCIDNLQGIRILLSATKPSKATQLASCRWIVRKQFTYDSDDDLMYEAALPPDPDDTHCIKELRRRNAGFLVVEPLDEPMCTKIIHEHATRNSTRIDSDAVASIMDSKGSSCPLYLRLILTMYDQSNHDANYLGDILNACDFSSLYELVLQQWKSMLLGDLVEALNALTQKPPHDPPPASTLPRPDSRKRNSRRESEHTAAIAAASQNSLAAPEMDEVERTKFLMERRALLARHALSLFAVSRFGLSEKDFHQLLEDAAPRPIRVQLLHLLLPHLMTIHRKDSDVVLYDISHNQLRLLARYVFLKDDALRHGYHKAIATYCEKMPTCQRRIDELPVQLECCSAWSQLQNCLVDMKMFQLWWDERNRQDFLAYWKTLRTSFSSHDPVDDYIRSLDEYIEVEGPTTEELLSLFLTITEFLRSWQRNDVKVKIQMQRPEPPQLKEFLNAQGSFSLAHLTDTESKQIQGIVDYLCPHADDGYYVRRWLWTQFPLIAVSFENLFLKKFTPPSDVAEAVESSVAPSPIHDKKEKPVAAPSPAKPYPHAAVLPKAVASTLADKKRILARHSPKKNTMQALELLNPEESGAFEFDEPATTGEISLTIPALREQLSELRARYDKLKFLTKERQQALAALDSKLIDAKANTSHHNQNSQLRDELVEQIRLITLDSTHGKQKSDYYKSILRQCETNPARDPNASALATAAIDICPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WXJ5</accession>
    <name>A0A6G0WXJ5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_010573</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000135">
        <property type="protein sequence ID" value="KAF0732282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WXJ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000320"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="645"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0732282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="695" mass="78227" checksum="A328CBF1CDEE10D8" modified="2020-08-12" version="1">MSTILPAIHKGSAVRTSKERPTSNNGGGEHERTLADEYFERICALESEQERVRSEIRQVRSLLSNNLQLREEQHSQSLTSLTHEMDKLQFAFQAKVQSDSMHQEKEKQKHALLFGEVVRLGKSVETIEMHVQKHIATIEQQLATHKNHTQSSTYEALVKAHDDSMEDLRSSVQAVRSAMTQLKSEVDSDRNNRWKADLDKQSQHSRADVTLVNELDMRLQTQVDRMASRLTSDKSELLRVVDEVKDSCRNDLRRLADHIVGVEQLVQNESMAMNRIVQGVATDWEVKFRTLADEMLTEIASRNAVWTQLDDQMRGQWTDLANATRDVTAAVQTRLGELQEVVPLEIQARQKAYDKLKRRVDALAKALGRTIETIANDVKANQTASTVRINTCVATQLELANKLEGLEATWSSRLDVVQRETHAAIHKSVQSESHQRQVSSSELANTVAECRRELMEAIEQYNDRLRKDTTADDLSALFETKIKAVEGALQQTKAKQELAVSELRMTLEAANMQWEINGAVQHCVADLVSQVVDAAASDSVDLVAWNSQQGIEWVVSQMNEELGRQSNALEWAKQELSTAQYSSDQHRLTDIQALQDAYQGISSHVRMMEDTLVTMAWNIEERTSQESVADVLRGCVASVESAVRIDETTAQLEEMASLLRQAQLTVESLRQQVDALVVVGQAPTDLQLQDDSFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WXP3</accession>
    <name>A0A6G0WXP3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_010564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000135">
        <property type="protein sequence ID" value="KAF0732273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WXP3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000327"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0732273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="128" mass="14880" checksum="C7FF96AF60123499" modified="2020-08-12" version="1">MFRDKRWVSNEVDRNRYRAWKTAALQVLQHDPSKRMVVLEIGCGIRVKTVRKAMEELVDEVFAFGNKQATRIRINPDIDDANEPNDSRIHIQGTGLATLQLLDQALRRSQRAEQIDRPSKKPKRNETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WY60</accession>
    <name>A0A6G0WY60_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_010475</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000132">
        <property type="protein sequence ID" value="KAF0732486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WY60"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017219"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000063">
        <property type="entry name" value="Multidrug resistance protein ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000610">
        <property type="entry name" value="Multidrug resistance-associated ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000997">
        <property type="entry name" value="Multidrug resistance-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="320"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="697"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="753"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="836"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="942"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="965"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="81"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="397"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="709"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1027"/>
            <end position="1261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0732486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1274" mass="140681" checksum="F815599FDC8DF4FD" modified="2020-08-12" version="1">MVGRSKTYNTFDSADPRASSWHPLDAASVWSTLSFGWAESLIALGNDRQLSSDDMWPLQDANKTFFSIYWRPFVGIGVLELFIAVCSLYGPGFVLGQVIAALEAAEFDSIYVLKLVGSLFGLSVANAVAKAHMSFLNNLVGMQFSACLRSMLFEKSLKLSAKSKKDKSAGDIANLFSVDVVNVMDFALNAHQMWVVPLQLLVVLFLLYQVVGWASFVGLALVGVITAINARAAVLLGRTEEELYGRKDERMQVLNELFGAIQIVKFNAWEEKFATRVQALRDSEVQSIKVFYEYVVVLMTLMSSAPVLVALAVFATFTLLMHQVLTVTVVFATIALFKSLQDAMANLPFSIMSLVQSLISAKRINEVLIMDEFDPANVQTPADASIVPAYGKDKVVVSIEDGSFGWDADNLLFRNINLKVHQGELVVIHGAVGQGKSSLCSILLGEMVKTNGSVFVGGQVAYFSQQPWIQNTTIRENILFGKPYDRTKYDKVIDACALAKDMASFPAGDRTEIGAKGLNLSGGQKARVSLARACYSDADVFILDSPLSAVDAIVSSEIFRKCFQGLLHHKTVLLVTHNPEIIASPEVAKAYLIQDGQITESTRSPTTLSPVAEEKSPLVSPLRQRRPYWEASYTEAPVVVRKHDSLLTPTASTPYNFKPVEMLFTPRGKDVNESHGRLVKEEVRAVGRVSKAVVFKYLECIGGWPAITVLLLVTVGMQAFKITSDLWLTKWSNDTNHMDPAVFVASVNYNMSVYGSLALGCCVFTAIGCACVFIFSVRGANKLFSAMLASLLEAPMRFFDTNPIGRLLNRFGDDVTSCDLNIPFGVMNMLFEASSALLTIGTTLVLTQWLGIFILPLMYIYIRIGAYFLEPLREVNRIQKTTRSPLISLVSEGIDGSTTIRAFGDKQRRRFQRFHDQELEVFCATRFANSSINQWFSLRIELLSDSIVAVLLLAVVVLHDTLSPGLVGLLITYGLTIPSNLAFLVNIWSRLETSMISPERILEYINVEHEGHRDGSPQQQWPTVGRVVFDNVSFRYKPNDPLVLKNVSFDVQGGEKIGIVGRTGAGKSSLMMALFRINEVASGRIQIDGMDTATIGLKTLRNSLAIIPQNPVLFKGTLRNYLDPFDEYSDEQLWSALRKVKLMDRLSTVEEKLLGPVEENGDNFSVGERQMLCMARALLRQAKIVVLDEATAAIDHATDQLLQAVIRDEFASSTVLTIAHRLDTVLDNDRVMVFDHGELVQCDKPSILVAQGSGIFFELVSEGGYMDKMTGTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WZ35</accession>
    <name>A0A6G0WZ35_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_010199</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000128">
        <property type="protein sequence ID" value="KAF0732875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WZ35"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018936"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF214">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026181255" description="Protein kinase domain-containing protein" evidence="6">
        <location>
            <begin position="21"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="237"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0732875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="507" mass="55886" checksum="50524A067328F839" modified="2020-08-12" version="1">MTRALGRLSGLCLVIVVVRATPIFNNCSGATPCFELNLGSACKAGDASKHNGAGLVFCELPLRCNDEDFCYGLGSDCVCTGDRPCKPLAGACEALSGNCSAKSPFLRWCPALTAVPPAPTNVTMMPLTLDSNDVKPPSSTNSSSITTANRTSTTLIIVLTTTGGVVALVIAIGFVILKRRQREEPSQDTYELKQTMPAFDMETTATAWVGLNSTSNLQYQQLNMAELERHKISPTDISIIRSIGSGTYAEVFMGQLDKDFIAVKRLRQSKRRDMASLVQFIDEIKLHAVMDCAAIVPFIGVSWTTPVDVSMVTAFMDQGDLYTYLQTSNPSTFEWPDKLRCAASIAHALVYLHSMDPKVIHRDLKSRNILINSSMEFKLTDFGISRQVDDHNTMTKGVGTCRWMAPEVLRHGHYTESADIYSYGVILTELSTHVLPYTDQRNHQGNLYTDISIIAKSMHGDLLPSFDADCPSWFVILGKRCMAFEVHERPTALEIHHVVQTELKKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X082</accession>
    <name>A0A6G0X082_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucan 1,4-alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">1,4-alpha-D-glucan glucohydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Glucan 1,4-alpha-glucosidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_009795</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal (1-&gt;4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000124">
        <property type="protein sequence ID" value="KAF0733231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X082"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008490"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004339">
        <property type="term" value="F:glucan 1,4-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2440">
        <property type="entry name" value="Carbohydrate binding type-21 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005036">
        <property type="entry name" value="CBM21_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038175">
        <property type="entry name" value="CBM21_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000165">
        <property type="entry name" value="Glucoamylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046966">
        <property type="entry name" value="Glucoamylase_active_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616:SF9">
        <property type="entry name" value="GLUCOAMYLASE, INTRACELLULAR SPORULATION-SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03370">
        <property type="entry name" value="CBM_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00736">
        <property type="entry name" value="GLHYDRLASE15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51159">
        <property type="entry name" value="CBM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00820">
        <property type="entry name" value="GLUCOAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026268568" description="glucan 1,4-alpha-glucosidase" evidence="10">
        <location>
            <begin position="22"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="CBM21" evidence="11">
        <location>
            <begin position="17"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0733231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="580" mass="61996" checksum="9591021AF4631D81" modified="2020-08-12" version="1">MVFAAVKKVFAVLAFIAICHAANEVKVNSYTFDGTKLTGTVTLKNLAYTKTVTVIYANTAQTWGNTCSAGYTSGPDSSNNEIWSFNCPISSAGITQFYVEYNVNGATYYDNNGGYGSNYQVTTPTSAPGTPGFQADITTFLSSGLPSFKTFLLNNISPKNVSGALAGSIIAASPGGANNYVFHWLRDSGLVMDVVNEFYKAGDTALEQTFWDHAAFNKKLQGLTTQTGLGEPKYNVDGTAFNNPWCRPQNDGPAVRASSFIRFSKAYLAKGGLLSKVVDLYNGTATGVIKNDIAYVISKYSDSNGCDLWEEQRGLHFFTVAVQRRAVYEARDFANFLGDAASAATYSAAATNLDAKLATFWNANAQSVQTTINARLLDAAIPLGAIHGNNGDGVFAPEDDRILSSIAQLESGFVSEYTLNQNVKTDASGLPLSLAIGRYYGDTYDGSSNSQGNPWYLCTLSVAESVFRAATAYVKAGSITAKALNQKLFNAGAPVGLGLNVATGTYAKGTTQFTSIIEGLKVYGDKHIRRVKFHGAAGNHFNEQFNRNTGVAQGVNDLTWSYAALISTNNARAELKALSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X0L4</accession>
    <name>A0A6G0X0L4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_009591</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000122">
        <property type="protein sequence ID" value="KAF0733341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X0L4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009127"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006461">
        <property type="entry name" value="PLAC_motif_containing"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01571">
        <property type="entry name" value="A_thal_Cys_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15907">
        <property type="entry name" value="DUF614 FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04749">
        <property type="entry name" value="PLAC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0733341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="200" mass="21819" checksum="B797594B748719AB" modified="2020-08-12" version="1">MSSESAPLTQQPPSYQNEEPTPGGVRVITHSVPAWKVGVLGIFGSVANVLMSTFCQCIVLAQIASRLGNVYGGYKGVLVGVFVFATLGNVFRLYAQHDWNIIETHGRPVDTFREAEATRFNIAAIFSALVIVTFVAWLRSRVRDFFRIPGSAAEDCCCSLFCHCCTVAQMSTQVEVYTPGQCSVGPRDTLPAYYVAVPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X0P1</accession>
    <name>A0A6G0X0P1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aminotransferase class V domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_009651</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000122">
        <property type="protein sequence ID" value="KAF0733404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X0P1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003752"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003961">
        <property type="term" value="F:O-acetylhomoserine aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071269">
        <property type="term" value="P:L-homocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006235">
        <property type="entry name" value="OAc-hSer/O-AcSer_sulfhydrylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43797">
        <property type="entry name" value="HOMOCYSTEINE/CYSTEINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43797:SF2">
        <property type="entry name" value="HOMOCYSTEINE_CYSTEINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0733404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="31959" checksum="ECC1FBC6184777AC" modified="2020-08-12" version="1">MNPTNDVFEKRVTALAGGAASAALSSGQAAQALTIFTIAQAGDNIVSTSSLYGGTYNQFKTKAIYVETIGNPELEVPDFYAISAIAKEHGIPFIVDDTFGACGYLVNPIKHGADIVVQSATKWIGGHGISIGGVVTDAGTFNWGNGKFPMMSEPSPGYHGLNFWTTFGPGGVVGANITFAIRLRVESLRDFGACLSPFNSFLLLQGLETLSLRVDRACDNALELAQWLQTHPNKYLHRGKYGAVLTFDVKGGLQAGRSFINNVKLASHLANVGDSKTLVIRPSSTTHQQVSEQSGEWCQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X0Q9</accession>
    <name>A0A6G0X0Q9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Photolyase/cryptochrome alpha/beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_009608</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="4">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA photolyase class-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000122">
        <property type="protein sequence ID" value="KAF0733358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X0Q9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009110"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043153">
        <property type="term" value="P:entrainment of circadian clock by photoperiod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.579.10">
        <property type="entry name" value="DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="CRYPTOCHROME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455:SF9">
        <property type="entry name" value="CRYPTOCHROME CIRCADIAN CLOCK 5 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="Cryptochrome/photolyase FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="2 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="7">
        <location>
            <begin position="37"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="279"/>
            <end position="283"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="319"/>
            <end position="326"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="417"/>
            <end position="419"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="5">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="5">
        <location>
            <position position="404"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="5">
        <location>
            <position position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0733358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="522" mass="59113" checksum="904C2D1D4529AE53" modified="2020-08-12" version="1">MDERPAPKRKEPSSPQERAASTPSPRKKQAVDKDMGPTSLIWFRKGLRLHDNPALVEAIRGARHLIPVMVIDPALAHPGKCGARPLQFFLECVQDLDRSLQARQSRLVILHGDPSELIPRYVKRWGVSKLCFEEDTGRYSQARDAAVRDSIASSVAVRSFSTHTLYKSADVRKVYAPNGYPQKYEAFLTRVRSLEIDDPLPDASLPETFPPVPDDAISESQSIPTIQSLGFDCQLDPIPLVGGETSALERMEKALEDEKWVRDFQKPQMSPLAIAPASTTCLSPYLARGCLSVRLLYSKIETILAKGTHSKPPVSLKGQLLWREFYYAASYLTPNYYEMEGNPVCRQIPWSRDAEKLEAWTNALTGYPWIDAAMTQLRQEGWIHHLARHAVACFLTRGDLWVDWRLGRDVFDKMLLDTDPALNNGNWQWLSASAYFHQYFRVYGPVSFAKKYDSSGAYIRHYLPVLRKMPDKFIYEPWKAPKAVQSAAGCVLGKDYPKRIVVHEVVSKELTERMAAVYKASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X0R0</accession>
    <name>A0A6G0X0R0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TIP41-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_009670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIP41 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000122">
        <property type="protein sequence ID" value="KAF0733424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X0R0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005010"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051330">
        <property type="entry name" value="Phosphatase_reg/MetRdx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007303">
        <property type="entry name" value="TIP41-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021">
        <property type="entry name" value="GAF/PUTATIVE CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021:SF16">
        <property type="entry name" value="TIP41-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04176">
        <property type="entry name" value="TIP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0733424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="34236" checksum="0EDAF58D0A2A3538" modified="2020-08-12" version="1">MTSTFYDKQTGVTALLAQIREHEEREDAQANAREEHGVPFKYKDWMIVAHKSHITPLQALEDLGNSVGLTPPEMVFGKNQLLVMHKPSGFCLSFIAAEALACCHFKAGDDKEQLQVSMARDQPSTKGDDVKKLAISYDWTYTSDYKGTLARVNGDGVANVEKNTVHVEATQERIDYEKLKVREEILWMDEVNLYEDELHDHGVSVFSIRMRVMPSGFYVLARYWMRLDNVVVRLNETRIHHLFGQDHFLREFTAKETTFEQLFAQGQPTHMSHYTNIDTFQHLLATKYSAYDKVFLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X0Z0</accession>
    <name>A0A6G0X0Z0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_009751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000122">
        <property type="protein sequence ID" value="KAF0733515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X0Z0"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0733515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="67" mass="7331" checksum="1E62520A84F23870" modified="2020-08-12" version="1">MPFSMGSKGCIGQKFAMAELQLVVATLVSKYDFAPTAKMNIRQEFGGITTRPVHVEMTVRRVQAPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X1I3</accession>
    <name>A0A6G0X1I3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_009494</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000120">
        <property type="protein sequence ID" value="KAF0733649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X1I3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019476"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001534">
        <property type="term" value="C:radial spoke"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035082">
        <property type="term" value="P:axoneme assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060294">
        <property type="term" value="P:cilium movement involved in cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22963">
        <property type="entry name" value="DD_CrRSP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006802">
        <property type="entry name" value="Radial_spoke"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13159:SF0">
        <property type="entry name" value="RADIAL SPOKE HEAD 6 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13159">
        <property type="entry name" value="RADIAL SPOKEHEAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04712">
        <property type="entry name" value="Radial_spoke"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0733649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="444" mass="49112" checksum="AB7344308D842DD9" modified="2020-08-12" version="1">MASGNLTLDEAKAYLKEERGGVNLYDHLSEVLLKLLVERPIDATSMFEHLSCTVRQERFRQAEPPNNRETGAEAEAKTLQEAWSKAATDLLKIQTEEGEIAQETPTGVADILDEANMFEWAGLGFSRGETFRLSLALQKSATLNATTKLRFWGKLLGSTMDFYVAEGELPEAYEPEDAAAEEGANGLNKYSYWVMKDDGTYQWIKLPPVRREQVIAARALRRFIHEDLEGKVNGHPPFPGTEKNFIRAQIARINAGTVLCPAGTFTVSEEGELEVPEEAPEPKTAAELSDPSNWVHYTKEINEKYGRSTPMPPNTNDDGEEVPWEGEEFVDPLRAIADDKPGSWRIDRLPATTSAAVGEMAIVRSLTWPGAVSIGVGKKFLNVYVGYGLKAKFGLDHQVQLPRKLAPDFGLSVDSDTNSLKFTNLTEQPDVLVDPSPPEEEAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X1U2</accession>
    <name>A0A6G0X1U2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_009359</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000119">
        <property type="protein sequence ID" value="KAF0733791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X1U2"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0733791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="92" mass="10192" checksum="85CF75AEE44F9DCB" modified="2020-08-12" version="1">MELIASRGRPSPTKIALLKRKAVGCRSLAILSTMKPCRRRIQDPANSSKRYSSPVAIPDLSATLEVVSCSAPYMGGEIQPRRQYFCMKALHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X284</accession>
    <name>A0A6G0X284_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RWP-RK domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_009190</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Putative transcription factor.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000118">
        <property type="protein sequence ID" value="KAF0734017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X284"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013932"/>
    <dbReference type="OrthoDB" id="6270329at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044607">
        <property type="entry name" value="RKD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003035">
        <property type="entry name" value="RWP-RK_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46373">
        <property type="entry name" value="PROTEIN RKD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46373:SF2">
        <property type="entry name" value="RWP-RK DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02042">
        <property type="entry name" value="RWP-RK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51519">
        <property type="entry name" value="RWP_RK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RWP-RK" evidence="7">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0734017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="120" mass="13948" checksum="1A1D700FF22B05E6" modified="2020-08-12" version="1">MPRTTPPRTSLTLEQLESHYHMPLKEAAAKLGTYEGALIRACRRHAIYKWPYRQLSKINRQMRFMDDVLNKLDGDVGVKTTEQRQRLDQQYAIVHEMTARRPPATDLKVAKLKISFLLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X3A8</accession>
    <name>A0A6G0X3A8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aspartate racemase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_008841</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000114">
        <property type="protein sequence ID" value="KAF0734380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X3A8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007286"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047661">
        <property type="term" value="F:amino-acid racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1860">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001920">
        <property type="entry name" value="Asp/Glu_race"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21198">
        <property type="entry name" value="GLUTAMATE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21198:SF3">
        <property type="entry name" value="GLUTAMATE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53681">
        <property type="entry name" value="Aspartate/glutamate racemase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="283"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="291"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0734380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="324" mass="35398" checksum="A0DFA8B8184DCEB0" modified="2020-08-12" version="1">MPQETLLGILGGVGPAAGLVLHQAILRHTQNHGTDQGHLDVVHISRSADITARPAFLAQNGTDDEMENPAMGMARSLKMLVHAAVSRPAKLVVGVPCNTFHAPPIWDVFAAAVDELDPSAHVVLLHMLQETVRMIRDIAPHAQKIGVMSTTGSRKERIFDNLLEPLGYTVIQVPESVQEALNDSIFNTEWGIKSTAPTIHPRAIENFQSYARILINLGADVTILGCTEIPMALSGSEVDGMLLVDPMVALARAMIREADPSKLVPLDMRLDLQSRIVGKPKRTLRSVRSGDDDDDTGTELLDDYDSDNDREAPVNVDAFRFCFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X430</accession>
    <name>A0A6G0X430_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Chorismate synthase</fullName>
            <ecNumber evidence="3 7">4.2.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_008659</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21020"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="EC" id="4.2.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>FMNH2</name>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
        </cofactor>
        <text evidence="7">Reduced FMN (FMNH(2)).</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the chorismate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.5" evidence="3 7"/>
    <dbReference type="EMBL" id="VJMJ01000107">
        <property type="protein sequence ID" value="KAF0734701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X430"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021153"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004107">
        <property type="term" value="F:chorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07304">
        <property type="entry name" value="Chorismate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.150.10">
        <property type="entry name" value="Chorismate synthase AroC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00300">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000453">
        <property type="entry name" value="Chorismate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035904">
        <property type="entry name" value="Chorismate_synth_AroC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020541">
        <property type="entry name" value="Chorismate_synthase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00033">
        <property type="entry name" value="aroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085">
        <property type="entry name" value="CHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085:SF0">
        <property type="entry name" value="CHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01264">
        <property type="entry name" value="Chorismate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001456">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103263">
        <property type="entry name" value="Chorismate synthase, AroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00787">
        <property type="entry name" value="CHORISMATE_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00788">
        <property type="entry name" value="CHORISMATE_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00789">
        <property type="entry name" value="CHORISMATE_SYNTHASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0734701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="430" mass="45765" checksum="69BC1A37B8DDC67A" modified="2020-08-12" version="1">MSSFGRFFRVTTFGESHCKGVGAIVDGVPPGLDLVEADIQPQLTRRRPGQSKLTTPRDEKDLVTIQSGTERGVTLGTPVSLFVANENVRPQDYKEMSNVPRPGHADYTYQEKYGIRASSGGGRASARETIGRVAAGAIAEKWLSKKFNTKIVSWVSTIGDVDMPLHELNNPKAPLYSREEVDTLGTLRILLAPGTTEADFVTSTDLTQPSYADLNGVIYNRVGTVLSPPPSDFDFEAWGASGELVPVRCPHPPSACAMATTIRECKHAEDSIGGVVTCVIRNAPVGLGEPCFDKLQAILAHAMLSLPAVKGFEYGSGFAGTRKRGSQHNDPFCKGEGRQLGVAKNDAGGILGGISSGADIYFRIAVKAVSTIGQAQETVDYDGEATVLEAKGRHDPCVLPRVPPLAESMAALAVADMALAQLARQGSLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X4Y2</accession>
    <name>A0A6G0X4Y2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_008480</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000102">
        <property type="protein sequence ID" value="KAF0735009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X4Y2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000068"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173">
        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173:SF74">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="248"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="281"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="316"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="349"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0735009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1235" mass="137561" checksum="A844B19D88545125" modified="2020-08-12" version="1">MGNDQSHHHQQSIQRSSSSGKSIDKRVRPPDHYNGLPFVVWNGAHHFAEPSSYKYSNKNTQVQGTVVFANPVKVDFELRNLPELGGNIAIVERGGRVHFPDIIRRLLKAGVTGCIFIEREEYLGPKMLFEGFHSSGRQTVDIPIVRLSKFHADQFLESKPQKVTLEFLRGHAALEHLVDDDIPFGISTASRLGETAVLRALLLSAQAKLSLKDIPVANALCDAAENGHVDCIEVLHSCGISLDEHKPNGTTPLMVACSVGNIEVARALIMFGANIDAEDVHDHTALMIAARDGSEACLRYLIRKGANINLSRNRKRGTTALHNAARSGHDDCVSALIEAKAELDIPSANSTTALMEAARAGNLGAVKLLADAGASLLAKDRDGNTAEMIAVQSGHQPVEDYLHERAESDSVKDQRRHIEEALKTPGFTLLDLIKLSDSEGVNIDVLKREALRNPKTVAWLEEPRIIFDVLKLMTSPPATTMDPVYGYYKVQHFCCEVALWYGSHVFETHGILDKEKCLGGTLDEVLVVLFCKVVNFYVNNRFLGPAILYFLGSESTHIVPWLICHIGLDSIRDTLVWILYSDLSKEGQTCLVQSGLFVCMFDRLYSWQRTLSWGVGTAYQRDSVENICSLLKYIIFPPSVYDPVVFVENHDFSLPLITARTPLGQQNELLRTLLVHFCRTENALTVFLDLGYAELTRQVNETDTKFPLQEGGALSVLMMLMSTLGYHKKKRDTTSVEVLLRDTHTEITTMLLPRVASFVELCKTFVTKRKPTGNTLLCIVTFLKRCIFLQHGGLNAALASAGCMPVLMSCFESNPSNSMLHHEITDIIRFVLLDPDQKRLPSCPLLNSMFLPGTSLLDFVMKSYHDRVQYKGHMTTIANSIFTLINTPVYKDKSTITCQEVVRQYTLATPEWAEFENILAKQNSVEMTPLGQRHAPLCSGCINLKESSLAYVSSTLSNIERMSGYLETIFSGAATFHCKVNTTEDFITGFLYKKDKIHDHIPVPEPTRVSSFIQFPVPMPFHALTFTLTYVGLCRKCDKLWYCDTLHSGMSNWTTRMKWVIPTSVRKWYSFGASAGPGGGAHGIQFTTKGYKNFLVLTDTWGRQEQWIHALEDAIEASATNAHVSSANALAIEIDNDADNSSIDAMKQSEIGVDNGERKRAQTIGEKGKELDLKMFQKSLTFNVKAKPMQLSRLPPRFQTDPNSTEPLTKEIKGGMRHVASLPNLAAYEQQFKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X603</accession>
    <name>A0A6G0X603_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_008258</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPO2/CSE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000100">
        <property type="protein sequence ID" value="KAF0735349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X603"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003926"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000507">
        <property type="entry name" value="Exportin-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005043">
        <property type="entry name" value="XPO2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013713">
        <property type="entry name" value="XPO2_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF8">
        <property type="entry name" value="EXPORTIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03378">
        <property type="entry name" value="CAS_CSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08506">
        <property type="entry name" value="Cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="8">
        <location>
            <begin position="32"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0735349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="986" mass="110627" checksum="B97F58B38C5F02AC" modified="2020-08-12" version="1">MAMNMGSPAELSALVQVLQQTLSPHAEPRRAAEAQLKEVTKRPNGPLLLLNVLRTPEVEMGVRLSASIAFKNLVKKEWDPESEGCIVPECKALVKTHIVSLMCDMPENLMKQLSAALFTIGEYDFPDLWPELLPQIIEKLGNPSSDMRTINGMLETSNAIFKRFRHAFKSDALYKELLYCLQQFQAPLLILFTAMTQKLQQPSDSLPAIATALRTMCRIFFSLNWQDLPEYFEDNIASWMQAFEFLLRYENPQLVSDNDDEADLLTLLHSAVLENVLIYAEKYEEEFAPYVSTFTEVIWQKVTTLSLLPKHDEVAAKSMKFLRSIAMQHGTTALFQQENILTELCNNIVVRNLQLRESDVELFEDNPLEYIRRDIEGNDGDTRRSAAIELLRGLRQKYDDAVSRICLTTITSLLQEYAASPSTKWMQKDVAINLVTALAAVKQTRARGVSEVHPKVPLLDIFSGHILPQLQNQRHENNPTALLLTAGALKFVATFRNQLPVQVMTTLFPLLADCLMPNQFVVHTYAAFCIDRLLTVKEDLPSGVVTVQPRRFNKEMLNPYLAPLLNQVFGILCDPSYPENDYLMRMVLRVLIVAQDTVLPLADTVVHKLTILLEKVCKNPSNPGFSHCLFESLSMLIANVCTLNPALTDTFEQLLFPPFQQVLISDVEALCPYVYQVLAQLLDMNPSRQLSAAYTNLFPVLLTPALWDRISTVPAIVKLLESYLRKAPTTMQGHITGILGVFQKLVSNRTTETHAFALLRPFLVYMPIAAYQPLLPELVKILMMRLQSRLSGRNAGIYTKEMIVTLSIFMAKHGAMTLVNAVESVQPGMMKMLVDPIWIENAPKAKGPNERKAALIGLTLLVCDTPFSKDTTVLPKLFPAISRLLDNKDDTSATLTKTEDEILIDLEETGYDAGFTSLHFASSGGVDYASHVPNGRQVCLESISRLSSSTPGFYRQAAEQGFVQAENQAGWEILLKAFEAAYLPFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X6U6</accession>
    <name>A0A6G0X6U6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zinc/iron permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_007986</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000094">
        <property type="protein sequence ID" value="KAF0735670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X6U6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017388"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF44">
        <property type="entry name" value="PROTEIN ZNTC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026079898" description="Zinc/iron permease" evidence="6">
        <location>
            <begin position="24"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0735670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="350" mass="37760" checksum="AF64E8D4AB3D8E5D" modified="2020-08-12" version="1">MSRNALISFFLLLGLAAAKRAHGNDVSDDDDNSLCGVVTKEDEYDHPLHMAAVFIVLGVSLLGSFLPVLSSYISWLRNNRPILDILNAFGIGVVVSTACIHMIPTAIETLANKCLNLSYDCLAMVIVLATILLMQVTETELTLKQSNGLTDDDKFLDTYDPVVSSSGDLVTQLSHRHHHHHHAEEQTKAAARKKINVLIFEVGVAIHSVIIGLELGVATGTSFTTLLSAICFHQFFEGVAVGSSAVSAFSTIRSSILTAVVYSLSTPVGIAIGIGIHSTYSETSTTSLWVRGILDAMAGGILIYTGLVELLTYQYTINGDFHRMSSSFRLLCYTCVWMGACAMAVVGKWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X6Y1</accession>
    <name>A0A6G0X6Y1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="8">PARP</shortName>
            <ecNumber evidence="8">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_007739</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the ARTD/PARP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="8"/>
    <dbReference type="EMBL" id="VJMJ01000093">
        <property type="protein sequence ID" value="KAF0735731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X6Y1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005696"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990404">
        <property type="term" value="F:NAD+-protein mono-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070212">
        <property type="term" value="P:protein poly-ADP-ribosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01437">
        <property type="entry name" value="parp_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07997">
        <property type="entry name" value="WGR_PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.140.10:FF:000001">
        <property type="entry name" value="Poly [ADP-ribose] polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.142.10">
        <property type="entry name" value="Poly(ADP-ribose) polymerase, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.140.10">
        <property type="entry name" value="WGR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050800">
        <property type="entry name" value="ARTD/PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004102">
        <property type="entry name" value="Poly(ADP-ribose)pol_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036616">
        <property type="entry name" value="Poly(ADP-ribose)pol_reg_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036930">
        <property type="entry name" value="WGR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008893">
        <property type="entry name" value="WGR_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10459">
        <property type="entry name" value="DNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10459:SF66">
        <property type="entry name" value="PROTEIN MONO-ADP-RIBOSYLTRANSFERASE PARP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02877">
        <property type="entry name" value="PARP_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05406">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00773">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47587">
        <property type="entry name" value="Domain of poly(ADP-ribose) polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142921">
        <property type="entry name" value="WGR domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51060">
        <property type="entry name" value="PARP_ALPHA_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51977">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 8" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="WGR" evidence="12">
        <location>
            <begin position="182"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="WGR" evidence="12">
        <location>
            <begin position="371"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="PARP alpha-helical" evidence="11">
        <location>
            <begin position="491"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="PARP catalytic" evidence="10">
        <location>
            <begin position="621"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0735731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="839" mass="92792" checksum="1A396C45EBD31727" modified="2020-08-12" version="1">MKTPPTVSKRITRSSSKAAFAAPAGKQPKSPMSNRTLTKAVSKKRKTVQKKPATIIEKRVTRSASKTSKQSTSTGSVFGTTPSNFGSFPSTYGASSFGATTTTLAQPKNGFNATSSSVTSFAASSGSFGATSSGFGQILTPFGRPSWCNGCQLSQQSLLDGTAGNHRLLDLGYHFYIGHAPSHSVWGNYHVKLQQVVGFGMAKFFHMQIIQDGFGLWTIFTRWGLLTENGEFKIVSTPNVISAVKEFEKIFKEKTDNEWKERHNFVVKQGFYQISTLPEQPIRPYNPFISSAFGQPGFKPSFNPPATTAPAFGGFSFGQPTPTPATTGFAAQATGGFSFGRPAPTSTPMSANASGHRLDEVYAKSMFSSSTHSVYRDYDVMLNQVNITATTSNNKFYRIQLIQTSPSTWDVFTRWGRVGEDGKYKRWCPTSDLNSAINVFKQKFHDKTKNNWENRKKFQLKQGYYEIVELDLSAGVPAEKIHRQIGDDSVPSTLAPPTQKLIQMIFDKDMFKNELVRMNLDPKRMPLGTLSIKQIQKGVAILDDLQASLDGGNPRASTLQTLSAKFYQLIPHAYPRHVIPPVLNTPVQLEEKYQMLSTLHDIVVAQDVEKALGENEPVKQNSLDLKYAELNSQLDLVTPDNPLYKVIQAYIVNTNGQYASMSVLDIWEVRRSEEDKKFSKFASTPNHRLLWHGTNVAVVAAILKSGLRIMPSSGGRVGKGIYLANMLAKSRQYVRAAHFGGQNVGCLFLVEAALGKMNEIRRDDSSLTKPPKGFDSVLAKGTLHPNPEKDQLITLDNQQVRVNVGAPIQSGVSSSFTHDEYLVYQESQQRLRFIITFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X766</accession>
    <name>A0A6G0X766_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CSC1/OSCA1-like cytosolic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_007750</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000093">
        <property type="protein sequence ID" value="KAF0735743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014471"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF135">
        <property type="entry name" value="CSC1_OSCA1-LIKE 7TM REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="389"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="668"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="846"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="880"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="931"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1001"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1050"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1135"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1166"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="4">
        <location>
            <begin position="504"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="560"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0735743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1310" mass="145582" checksum="B5FD22110967D1EF" modified="2020-08-12" version="1">MDTAAVNSSDATTRNTVAGESNEPIKSSTSQSNQGTFEGNATQQDDGWQLSMNDLVSPSSSRPQTKGSSDFTDNLEASLQVQGRPLSLNDFAPPPSSQGQRIDLSQCTDKFENPLRIEGRPLSLNDFAPPQQYHDTSHHIGRSNPDREGTIVAQSQQHAEKWTTKLDGRPLTLNDFAPPVQHPIEPNTQMEQELFGNGEQLDVFDQSYSISGGDFNNSQTGALDQPGQMTNDEFTFDQEDSAFSGGGWSKSAALALPPLPEPVEVKKAKTHKQTMSRADMIKLAKQKAMSERLGGGKSFSKVTMKDIADLGTGIHLYFDFTKSMGITFGIMSILAIPTIVMNATGHGFETDQIDPLRFCTLSIANLGVNSTMNATDYCLGNPFTQNPNYVSYIITAFDLLFSLAFAIFILFFRNKIRSAVAAQGESVTPAKYAVFVRGLPRWATEELILAHFNSLYDPTVPRHEYPMYLGCWGKRREVKERPNLTRGGNLSKPVKNLDHANDNKLYKDKWIAQISIARPTGGLLRTFLAMEYLTAKVAELQDILDTYKGRTMDKVAEQTIPRIEKQLTKVQEKLEKKTSKLKALRKKGGSAALHQCGNVFVVFNSVESQKRCVHDYRTSSRWYARYFQPKALRFQGKHRLHIVPAPEPSDIIWENLELSDRERRFRRYFTNFIAFLLLLLSCGIISLAQSAQQSFAKQVIPNFCSEAVPAVFAGDYNSIDNYTWALGWNPNPTGEVCPAQSYYITYYNGIRSNVTGSNPCLDPCISTSSSVDRNCSTLPCYRPEFLTAKTRPCASYMQSDMLQCYCEPKLALAIKLFGIIQGPKKMFQAELPCEGYLTNYLRKNGAIVLAASVVIIVNVFLTTILRAFGEFERHTSESELASALVIKLFFAQFLNTGVIVLLVNANWTKVPLPLSLDEILHGQFDDFVQQWYVAVGVGISTTMMVNAVAPQVVPFLMTFVINPISQCLGKRSAITQKQLDEVYAGPPFDISLRYPLVLNTVFVTMIYCGGLPILLPLASLGCLITHLFDKLTLMRLFSIRTAYDEALGQLAYSMLPFALLLHLGFSTWMYGNSQFLQSNLIDVAWMLGKLGISNADEVSDVNALFEDFKDLLAKYDPFGQFGLLSKVFRVNVFPIFLVFVLTAVALFLSTFFGSLLWPLFDKTVGLVLRVVSFAGSSALSGIYKKIFCRRKLSPDTTISTIPQYPDFAGPFQMPTDPSVKVDASKGYETIEGGQILIRRWLVETPDRSTGDQMLTWEALNGPVKTYSIVANPKYKNAFAEMENAAKRHQSVAKSATNASVKKASLVVPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X8L0</accession>
    <name>A0A6G0X8L0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_007427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X8L0"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0736408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="180" mass="17843" checksum="3A51DBFBB26BB563" modified="2020-08-12" version="1">MSTLKMLLVKKRKLLIGCGVLLVATIAGVVALVAGGKTADATTGSALPPVTPNTTTTETTLAPNLLSDVIVSNSVASAPTSEPTLGSALESANIGSTNSTNSTDTPITTPAATPNATATPEPTPEPTTTTPAPTTTTPAPTTTTPAPTTTTLRPTALAPKTTAPQINDNGSGLWGAQSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X988</accession>
    <name>A0A6G0X988_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_007107</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000088">
        <property type="protein sequence ID" value="KAF0736657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X988"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016955"/>
    <dbReference type="OrthoDB" id="1929172at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026122402" description="GOLD domain-containing protein" evidence="10">
        <location>
            <begin position="20"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="11">
        <location>
            <begin position="29"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0736657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="241" mass="27402" checksum="0A89F33676271804" modified="2020-08-12" version="1">MWLLRCGALLVVWLSVSLALIVTIPGGKRECFIEHIKTKRTAYLEIAVLETNDKYDIRLIAYGPYQASPSATQTDLQFFDSLVTTAPANEQSNDVQRNGFNFDTEHRGGWYKFCLSNEHSSFDGKKVDFSTRYGLTNENDLGNEDLEEASTKEMHIATVKASLEHLSEMFNSIQSEQSYYIMRDKRHSKTAENNQSLVFWWTVVQVLLVALVYGLQSRLMNNWFSGSSLLSSTSGSGRQWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X9I1</accession>
    <name>A0A6G0X9I1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_007106</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000088">
        <property type="protein sequence ID" value="KAF0736656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X9I1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016956"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026270768" description="GOLD domain-containing protein" evidence="9">
        <location>
            <begin position="19"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="10">
        <location>
            <begin position="28"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0736656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="241" mass="27390" checksum="9B286CE0C40BB616" modified="2020-08-12" version="1">MGALKLIVTLATIHAVAAFTMKIPATKKYCFNEEVKTKRTAQLRVAVIDSFDPNDYGIRLTAYGPFVTSPSEKQTDMKFFDTVVSTPPKVTVKGVVKPAKDKSFSFNSEHRGGWYKFCLENEHTTYQKHVLFHASYGLTTDGEWGSEDEAEAETKQMHMEVVGNTLNYLGSLFDQIKFEQLYLAERNERHFKTLDSNSSGMFYWTLLQVLLVAAVYGAQSYFLRQWFSSNGLIGTADRRWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X9V6</accession>
    <name>A0A6G0X9V6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_007178</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000088">
        <property type="protein sequence ID" value="KAF0736732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010821"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051880">
        <property type="term" value="F:G-quadruplex DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867:SF12">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867">
        <property type="entry name" value="RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3146"/>
            <end position="3260"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="275"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="428"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="519"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="578"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="761"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="999"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1304"/>
            <end position="1497"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1544"/>
            <end position="1648"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1684"/>
            <end position="2221"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3076"/>
            <end position="3126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="3192"/>
            <end position="3201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0736732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="3260" mass="369566" checksum="9F3238037826DA93" modified="2020-08-12" version="1">MDGGDADIDHVRGKDIVLEILREVHDYFLTNDPSKKANGTIWHGLDRAKLAAVCAAQIDNTLHNDNEANPADDDSQTQEYAVIQEILAGLIEKRLLATQAQLTQGPVDVACLQHQFMSMTSKQVQTNESISTKSDVKVLAFWALDELHKRSSVDHLRDTIRAQDALIQAMQREIDALRQSPKDDSTIGKFDWSPESSSQGIQWTNVDLDASIDDLRDIVQDSHRNNLDILRDHIRALEGQLADATRYNAEVAKLNHHLKQELAENQPENDFVSSMSMLQRQIHDLETALAKATSHNEALEAELAVPGANLAYLSRQNTLLQQRVNIYKNELDAQIALLRRLEPTKDNGSECPTHFNGPCSDLMEALRTEILTAREQHRSEMVGLLEHISQLTQENHALRDPHLAAQLSENNLEQLSDEHPTRSVHAENAALLAQIQAYEATIATTEEAMGRLRRERELQEKEVDALLEKINPLVLAHEKIVAEKSQMEEDLTRRDEMIHALQASVYEMKREIKVVTADFDAIVEEKESLVEELEEWRKKRENGEEGSCETCVGLNNQIEELSQEVCTNLDDKINMKQLDQMQEALETAEAEVRPLKKSLASKEQTIQESNHRVSELERRISHDKVEFDKAVSERDRAIEALQSRVHDLKREVNVLTDDYDSIYEEKQELEQKLDEVETQLVNLQDELAEMDQLVSRLRLEIETWRMWYEQVMMLREEERTFKVNFDVAFIDLQTKLIQETNRADELKTATDDMHSAQTNLLAQRDEDINKLKDAVIQLKDRLAVSILSEEQLKEQLQLALEDKAASEAEKDSIAEAKEQKLIKQLEELMANREATDMEWENKWLAMHEENQTVRSDLEDVSRQLRQENLRLESTLAALQAQHNTNLDEKNTVLADLHAKLSDLEISKATMAADIARLEQEKLAEVDELNQSRGELQLRSRSLEDELEHLKSAVNTLNVEKAEWEKKAYELNIAVEDQFSLRKELEIMFTNKEGEFNDVLQQLQDKISSLTKSESNLKNQLDEVKQLKSEVDASLDDYKRQLKISSSEYSELEKTATSLVQANDGLTNQVNSLKHSVDQLKTQYEAAKSELDSSGAECKLLTEAVIEKEARLAELAAQNNALIAREMALQQELSQMSEEKSILEMSLPEHEEKLAVLSHAHSELGSTSKTLEFENIRLQDLVQTLTQEKRDCDAAFHQAKSTWNHKFEAMTFDRDSFAAKCSVLETSLNQKEDELSKLLVIGQSLKDEVSALTASYSAVSSQLEVVSEENTELAHQLEKSTTYLEAKTTEWQQLETTLGEKNDTINRLQALLDQFKGRIETLTTSESALTQQLESVQEDMDKKTSAMADENSKLLEEVVLARKQMEDFTKERDAALERTTDLSAELAALRAQLESTIAEKDASMTRMQDLLDRFKEKIVVLNDSQAQLANEMESNRLELQGELTIKDDEIACLQSEIDNLTKKLVNATNNLSAVTEEKDEIAREVSIVKGQIKDLQAENDAKCTKLKSEVDERDENIASMQTLLDEMKVITATLKTSEVTLSKELQNKSEELNSKQADVDRLQSQCCALEDELKVLSSHVEHLSVEKEELVFQAATLEARARNLEASSELLSNKCSELEDVKKQKDEEIAHLKQLLSDLKEQVADLTKAEAGLSMQLHQAMEEKSSLEMSLPEQVEKLASLSRSHGELELTAKFAHEENEQLKSNVAELEYAKTRLASEITELHSKVEQQASEIAGLEMSLSDTTNQIAQLQMVLDRFKLKVDALSKSEKELTNQLTQLRDEKAQTEEKLHEEREKVTTVSRARDALELASANLREDVSRLQAELKAMTEKHETISAQYDAHIDECSQHISRLEAQEAELINELNDNHTKRMELEASVSHTADDMSKLQMQLQRMKEKVSSLTKSEESLSKQVVFLTQEKTALELSLPEQAEQIATLSRSRGDLESTAQNLQTQNKKLKSEMEAWSVKETEWVKEKQQVESSARAQIQILEDKLATTELSAKQLENIIEAKSAEISTQDKLVTKLQEEVAKLLRTESTLHEELLQIQAEKDALAQRLPEQEDNLLSLSRSHNELANNAQSLAAENAKLKFELEALSQDFAQKSAELVSQVEQLQRIAKDSELRCSELTHEHANAEERWVQESNELQAELESKEEEIAHLQELFNKEMSALKLEESEANRRYEELSTLHIQVTSLYDDLLEKHKLLTIQHEEKQSEIDELESHWKLKCAELSAQLLTLQELLAKKDNLVLDLNSTVATADDRIAQLQSLLNEKTNLISQLEHLRATRPNVTQRHEQLSLPDDYALLVSENDQLRLGQENLNTIVEVLKEQLAQAKEQNEALPWISSFVEDIAPVLGLTNVVPVTMDKMQSTLLDVQTSIHSLSTKSGDLGAMKVDDLSGSTGWLKAIEESNALNDKADDLTRKVNRTRDIVVPTSSVSLFPDGMAKDVMSVVLEIVATFDDAATSTDIAATLNEAWHYRQRLLGQLVAAMHHVHPLPSSLPREEQVDAWLEDMKDAVYVTNHKVLSSALMTMHRLLYPSHVATNSMDLEQWSEYAASTEFADNLRQYVSRMNDLEDDSRDLNEVVLPFLTQYIHENPEGSSDADAVVDIWKRNIQAMTEALTTMHDATFNEKKTMTWPAWIEYLRSQAFAELVHEKHAEAHDLCVAIRTLGAAVFPIDSLPTKDTADVASWREWANTIAFDEGIASTKTKWTRIDVENQAMCDALQNIHAVLWPQQEMKPSMDSTEWASYIHSQPFVDKLRQLSGQDKAICAAFTKMHRAITTGLDVSTHSSMDVPRWTEYIQSDKFDERLKKFAGRLDEIERDGLALSEEIATMVRLIDTTPKDLTNWQEYVRSADFTETLDRYAERQSELETDSDNLHSQILPMLLRELHHLTANSPIDQIISAWEAKTSELESSVKDLVNSVNQIVEVPLNVQDTVHDTIRACNEALSRVSPQHHLESAIIAPPTDLNFEQLVAMMQSNKDDPQLNQLRSTLSKLEGHQEKWAADMSSQPSEDDSDVMWPDALRAMELAKECQLAAIHVLETHNRTCIAKTRAEIAMKCSVQRAFLRWKHKAAMAAAKEAARENHLEAIEALKETQLNQLIKFRKHALTEKAKAVEDAKRETEERLTEYFVKREENLRLEQNLMRKQDEEHSNSNDSNSVASDETKPKRRPVSASSVSRRRDSLGGAQPPIKKEPAHERVAFGSSVSRNFTPPPASAGLPTHSKVVEQSATCGTTLERLKQTNASMTKKVRMMSNPQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X9X6</accession>
    <name>A0A6G0X9X6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">pyridoxal 5'-phosphate synthase (glutamine hydrolyzing)</fullName>
            <ecNumber evidence="3">4.3.3.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_006923</name>
        <name evidence="12" type="ORF">Ae201684_006924</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + phosphate + 3 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="4.3.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the PdxS/SNZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.6" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000087">
        <property type="protein sequence ID" value="KAF0736764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VJMJ01000086">
        <property type="protein sequence ID" value="KAF0736910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X9X6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003639"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004325"/>
    <dbReference type="OrthoDB" id="65603at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036381">
        <property type="term" value="F:pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04727">
        <property type="entry name" value="pdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000001">
        <property type="entry name" value="Pyridoxine biosynthesis protein PDX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01824">
        <property type="entry name" value="PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001852">
        <property type="entry name" value="PdxS/SNZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033755">
        <property type="entry name" value="PdxS/SNZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003215">
        <property type="entry name" value="PRK04180.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00343">
        <property type="entry name" value="pyridoxal 5'-phosphate synthase lyase subunit PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNZ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829:SF0">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNZ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01680">
        <property type="entry name" value="SOR_SNZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029271">
        <property type="entry name" value="Pdx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01235">
        <property type="entry name" value="PDXS_SNZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51129">
        <property type="entry name" value="PDXS_SNZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0704">Schiff base</keyword>
    <feature type="domain" description="PdxS/SNZ N-terminal" evidence="11">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with D-ribose 5-phosphate" evidence="8">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="220"/>
            <end position="221"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR029271-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR029271-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0736764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0736910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="284" mass="30681" checksum="898F06E8E98E787F" modified="2020-08-12" version="1">MLKGGVIMDVTNVEQARIAEEAGAVAVMALERIPADIRADGGVARMSDPQMIEAIKKAVTIPVMAKVRIGHFVEAQILEAVEIDYIDESEVLTMADDENHINKHNFKVPFVCGCRNLGEALRRVAEGAAMLRTKGEAGTGNVVEAVRHARSVNREIRRLQSMDADELFVAAKEMQAPYELVKEVAATGKLPVVNFAAGGVATPADAALMMQLGMDGVFVGSGIFKSGDPAKRARAMVQAVTHFRDAKILKEISTDLGEAMVGIQDLKKSNVNFRDREGTLHGTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XBR2</accession>
    <name>A0A6G0XBR2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chitin-binding type-4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_006667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XBR2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015573"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35559">
        <property type="entry name" value="CHITIN-BINDING TYPE-4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35559:SF1">
        <property type="entry name" value="CHITIN-BINDING TYPE-4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0737508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="32485" checksum="D126925617E7E129" modified="2020-08-12" version="1">MLDPWGLSRPSLTSVIVVFAMQRAALVLLSAFAGVVHSHAWIDCSNYIIETGEDALHFKRANCIGFPRCAAERNGVFGLDSGLAYLQSVKGCQCDRSSSNAYTDATPMATYTPGQRVCLAYPAKNHVADVCTNQYIPDNGMKIYRSDEGATTDPDLHKWPHEIPHLNGVHTDGQIDYKGFQNCPAFCENNGTNMDKALCTVCFDLEPDLALGSYTFHWEWQFNEGQWYVSCWEANVVASTPSLRFPSPTAGGTPSTGASPSVVPNPAPSPATTPHPSVARTPSPSHNYGRGYGDEIECS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XBX8</accession>
    <name>A0A6G0XBX8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein RFT1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_006680</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Intramembrane glycolipid transporter that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. RFT1 could mediate the translocation of the cytosolically oriented intermediate DolPP-GlcNAc2Man5, produced by ALG11, into the ER lumen where dolichol-linked oligosaccharides assembly continues. However, the intramembrane lipid transporter activity could not be confirmed in vitro.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Endoplasmic reticulum membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the RFT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XBX8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015559"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034203">
        <property type="term" value="P:glycolipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007594">
        <property type="entry name" value="RFT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13117">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MULTISPAN TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13117:SF5">
        <property type="entry name" value="PROTEIN RFT1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04506">
        <property type="entry name" value="Rft-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="366"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="402"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="426"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="456"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="499"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0737523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="533" mass="58958" checksum="581ACDB3BDF00675" modified="2020-08-12" version="1">MSVVDKVVSGGGRLLALSFLQRGGTFVMNILTLRHLPTHVSGIGLSLELVLSTTFIIREGLRLASLREAGLVSGSKTAVPVQLRQLMNTSWLCTALGLLCTLAAAFWMAPRLYSMDAVDYPTFQLSLWLYCLSAAIEFFTEPFYILAHSSLLFQLRVQAQGWGFFAKAVVQVIAVLYFHQGMLAFGLSQVAYAVVHGWIYVNYFMLQLGVPSFPLGSWRDFFPHVLGASRVGTSRALLQLWTTLTLQSILKYFLTEGDKLVLSAFEASQQQGEYAIAFNIGSLAPRLVFLPLEDASKAMFSKLLASDTTATITASARADANRLFRLALKTMSLIGLVFVFFATNYTRTLLYLLVGYAKTLEDIPLVLSWYCVCVYFLALNGICEAFVYAVGNEAALQRLNKFLVLFFVITSASAVVLMHFCGLGTVGIVLANCINMACRILYCLDYIQNYFGDTSIVALFRSSLPHPAVLVAIATSWIITFASERYFRGPSLVRHGCHVAVGAALFGVNAALVYRLERSFLREVMSLRRQRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XCN9</accession>
    <name>A0A6G0XCN9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutathione transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_005922</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0737926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XCN9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020017"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006691">
        <property type="term" value="P:leukotriene metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050997">
        <property type="entry name" value="MAPEG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10250:SF26">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10250">
        <property type="entry name" value="MICROSOMAL GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0737926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="16484" checksum="28FA4F4118713324" modified="2020-08-12" version="1">MGHDMFIPSTIQPDHGYVILVVVLVAFVNLWAGMKVGAARRAYNIKYPQMYAEKSDEYFLEFNCVQRAHQNMVENLPVFLSLLIASSIYRPMWAALAGLIRVLGFIVYVISYSSGDPEKRLFGSFGFLGLFVSVGLCFEAAFRLVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XF07</accession>
    <name>A0A6G0XF07_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_005401</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="VJMJ01000070">
        <property type="protein sequence ID" value="KAF0738789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XF07"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017554"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF9">
        <property type="entry name" value="CHITIN SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="500"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="527"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="562"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="603"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="633"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="731"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="763"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="11">
        <location>
            <begin position="115"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0738789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="815" mass="91481" checksum="F7B510D36CF50A80" modified="2020-08-12" version="1">MQQIIAKQINKSQCVCPAHVKTKLLPRSKNPKSTTVMLGGQRTSEKASYVTFNGDITPRAKQQLSATEIIKRAEKLDYYLQLAYGYAKQIEEMSPIATVSMPLVQQAWEGRGYQLPYRTSPEFTDMRYTAVRTKDPINFTNDGYELRVKEYGKTVKVFVAVTMYNEPASQLESTLQGLAKGIAYMCEQQGYDYWQHVAITVVADGRTKVNPSTLAYLQKLGGFDKQIMNEISSGMSTKVHLFESTIQLPTEVEGLFYPPVQLIFALKESNYGKLHSHLWFFNGFCEQVDPKYTVLVDVGTIPGETSVYRLIRSMERNPQIGGVAGEIAVEKPQFLNPVIAAQHFEYKVANIMDASLQSVFGFIGVLPGAFSAYRYDAIRASNGEGPLVEYFKSLTASKKELGLFVGNMYLAEDRILCFEILARKGCKWTMHYVKDAIATTDVPETLVDLIKQRRRWLNGSFFAGLFAIWNFGRVWRNTAHSIPRKCAFTIQFCYLAIQNVLNWFLLSNLFLTFYYILSLALFYRSPILLRVILTVYFVLVGSLIVFALGNKPGHRTAGFYRISSYVMGTIMLWVTAISLYALSGQVSYLDIRPDLPSCSVANWELPAGAMASIGLIFLSAFSHGEFTILASTVQYYFMLPTFVNILGIYAYSNLHDLSWGTKGIDSTGHFGGASGGTSIKQLVAIQLNTANMDISLEADKQKVSSIFSTIANCQQQSVAAEHEDVDSSFRVFRSALLLAWLLSNGAWLYFATSSISCSCYLKYLSYTVAVFNIIRFLGAIIFLGFRITRGVVECVERLAYLSSPDCLPRYRAERY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XFM7</accession>
    <name>A0A6G0XFM7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial import inner membrane translocase subunit TIM22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_005257</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000067">
        <property type="protein sequence ID" value="KAF0739077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XFM7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006747"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0739077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="134" mass="14079" checksum="E492ADF6BBE03DBA" modified="2020-08-12" version="1">MTKTATCDARLAQLVYRGVVTGALWTVSIDAYEHLCLASAGKTRLNPRFLLKSTAMNCAGFTLFLGTFGGVSCAAEHLRGKDDSLNTFLGGFAAGLLLTQNPQTKIALPVRTSLLTGLTCGAFAAAFATFSHDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XFX6</accession>
    <name>A0A6G0XFX6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,3-beta-glucan synthase</fullName>
            <ecNumber evidence="3">2.4.1.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ae201684_005111</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[(1-&gt;3)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;3)-beta-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21476"/>
            <dbReference type="Rhea" id="RHEA-COMP:11146"/>
            <dbReference type="Rhea" id="RHEA-COMP:14303"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37671"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.34"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.34" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000066">
        <property type="protein sequence ID" value="KAF0739186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018823"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000148">
        <property type="term" value="C:1,3-beta-D-glucan synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003843">
        <property type="term" value="F:1,3-beta-D-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006075">
        <property type="term" value="P:(1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026899">
        <property type="entry name" value="FKS1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003440">
        <property type="entry name" value="Glyco_trans_48_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741:SF48">
        <property type="entry name" value="1,3-BETA-GLUCAN SYNTHASE COMPONENT FKS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741">
        <property type="entry name" value="LYST-INTERACTING PROTEIN LIP5 DOPAMINE RESPONSIVE PROTEIN DRG-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14288">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02364">
        <property type="entry name" value="Glucan_synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01205">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="564"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="602"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="656"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1504"/>
            <end position="1524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1536"/>
            <end position="1557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1569"/>
            <end position="1587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1630"/>
            <end position="1649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1695"/>
            <end position="1714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1774"/>
            <end position="1791"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1807"/>
            <end position="1827"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1848"/>
            <end position="1865"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1900"/>
            <end position="1926"/>
        </location>
    </feature>
    <feature type="domain" description="1,3-beta-glucan synthase component FKS1-like" evidence="13">
        <location>
            <begin position="217"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="160"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1957"/>
            <end position="1993"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="721"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF0739186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1993" mass="227197" checksum="07CA5E6D6CD653BF" modified="2020-08-12" version="1">MSSVPLSPALEAQKALYDEAMVHVNAGVAAQSANNQAEAEKEFTAAVAVLTKGLALKFPYEDQEASTRLGKKMARYLEMIKGQHGKAPESSVAKYNILDFDNLPERYSPVVKLLTSSPTHGDIFASMQKIFGFQETNVKNQKEHLLLLLTNYKESLETPAPEVYSEKQKKNAKDTPPELPKDADDAAEQAVKKLHTRLFDNYNKWCKYLKVQPAFSSEPLADLVLFFLMWGEAGNFRQTPELLCFLFHSLCGTAKPTDTPKEPGAYLATVIRPIYLEVKKDNDKKTPLGQRAPHREIRNYDDFNEFFWTKKCLKFDAYNIKEALGSVDKKGNPKDAPKTFVETRSWFRALWSFRRIFLFNLSLFIATVGYAVNMVLLCPESPIMYGADLGKDVAIFGKQYYNPKVDYGLTNGDNVPDTESGCNLPKLATCLGVSNFVPGQTFGVIPQDFRMLLADVPFQPCIEKLSGRCTCYLEILDRCFKQVGTGRAIVDSSSGDFRDFQNVKYDQSKCMPDWRKAAYQVINNAGPGLLNCGTCMYSTMEIPSKLPKLLGQFVDMSRKDKGPLIFGAGAAVFLIFFVGEINNRLFSGMFIGYVGRNLPVPITAFLRYMCFWLFLFSVKLMFDYNFMVKNLVETSLMIWMSDPLQYLKVSNFMIQASYHNIIYILFLWLPAFIVFMYDAQIFYAMFSVVFGSIRGFNLRIGELRSFRILRQSFKNIPKMFNKKIIENAVEVELHKQKLEDKKNGKKKKAEQSDEDVKKLLEVTSTTYTGSEAPGAPAALGHEASSKRNFSSVSGIGGDEFHRVIPFALAWNRCLKSMREADVISNRELSVLSYLIESKDKTERRLYTPVFLTAGKLDESLEIITDCGVVFDRLKSDKKKDAALEKVETSMRNRLKKDDLRVEALLGSYKFTSRIVRQLLGEAHADLDECFAFIEESVANHKILTALNVANLHALRTASAEMMKAIIDTPKGVKEDSILFTRALYRVTDTTEQVINNLKKALSKQEALAKILNDTPLKPNAFFIAPESTQQYAIAQLQALINDAPSMAIVNRAYQALTVDNFDAEPRSDEGQRRLRFFANSLFMEMPLAQSLKRMHSLSIATPYYSEIVLYSIKELTEQNDDSIKLLYYLQTIYHVEWDHFLERFKVKDEHEALAKVPEEVQLWASYRGQTLARTIRGMMYNEEAIKFLYWLELGNNEPMPENGTKELDEMVALKFNYVVTCQIYGKQKEEGKQQASDIDYLLKKHPSLRIAYVDGPKKMKEGPPKYFSCLVRSSNDKIVEVYRVELPGDPIIGEGKPENQNHAVIFSRGELIQCVDMNQDGYLEECMKMPNLLATVDRPEHKLSPLTIIGFREYVFTGGVSNLASFMQIQELSFVSLGQRMLAYNYVRQHYGHPDIFDKMFAMGTGGTAKASRGINLSEDIFAGFNSTLRGGRVSHEEFIQVGKGRDVGMQQLALFEAKLSSGAGECVTSRDVMRMANRLDLFRLQSWFYGNLGWYFTQTMTVFGVYFFIYGKIYFALSGMDAFYLQLGRLGISGVLNTSWALQFGFLLVVPVIGVVGVEKGFRHGVSYLLYNVLTLGPLFFTFQMGNRMHYFDRTLIHGGAKYRATGRGFTIKHEKFAELYRFYAFSHFYRGVELMFLLILFAIYGTFNWCNCSWTIDHEFYNDVEPLPYEWRQRCYSNFYQQCVLPTNQNYGIMSYSLWLIAATWVWAPFFFNPSAFDWEKLMADFADWQNWLKTKNDSTESWYGWWQNELDFMEHSSFFARFVTAFRKTRFLLVAIGIYLQMMYRLFYKNLNKTVAEDNPMKPYILAGAILVVLMILGCCAWIAGRVAKKMSSKQRHLRKLKFNLSGIALVLILASLLYISVGNLVEIFVIACLGMYWFLQVAICRRKEEHVLYIQAAQFFDIAVGWIVFGPILFISMFMPFVSAFQQRVMFNSAFTAGLEVSKLLGNDVVAESKAPTPSAPLKEEPKPKVKATKKKKTDEPTATHYGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XG38</accession>
    <name>A0A6G0XG38_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_005165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000066">
        <property type="protein sequence ID" value="KAF0739246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XG38"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010074"/>
    <dbReference type="OrthoDB" id="77969at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0739246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="75" mass="8142" checksum="4AF5ECA65F700445" modified="2020-08-12" version="1">MVRLNLTNKFRTSAVAAKTTKSTIFTSLPRFNVQATTAKPALAPRKLNEKLSFVTAKPVKTLYSLGTAKTNAFAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XGV7</accession>
    <name>A0A6G0XGV7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_004928</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000064">
        <property type="protein sequence ID" value="KAF0739359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XGV7"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="8">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0739359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="164" mass="18571" checksum="0E22C53318628D9C" modified="2020-08-12" version="1">MGQRDVRMKVINEIFGAFQVIKLNAWEEKFAENLGVERKLEVKFLWNISVWFTLSGVLLYLGPALVTIASFASYTLIQQETLPASKLFTALSYFTMLKYPFSTLTYVLATTLQAFVSMKRVMEFLNMNEKKSDVVWTPSTAPADKIKKHSDENIAIAIEDASIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XGZ6</accession>
    <name>A0A6G0XGZ6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">P-type Ca(2+) transporter</fullName>
            <ecNumber evidence="2">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ae201684_004919</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="2"/>
    <dbReference type="EMBL" id="VJMJ01000064">
        <property type="protein sequence ID" value="KAF0739350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XGZ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010478"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02081">
        <property type="entry name" value="P-type_ATPase_Ca_PMCA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000029">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000018">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF369">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="343"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="786"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="853"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="995"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1026"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="16">
        <location>
            <begin position="63"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF0739350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1065" mass="116748" checksum="3C0F4A436923B673" modified="2020-08-12" version="1">MTRVTPVNPKKSDLEETAFILPNTPGPGRIEIEPKSLFGITREGLAEINVDQMTETNLKNLQDLGGIEGLAKKLNVDLRVGLSKSEIESNFSQRRQRFGMNTFVEAPSNSFLSLFLDCFKDTTLIILNLAAVASIVTGLIENPSHGWVEGFTILVAVVLVALVSTTSNYTKELQFRALNAKNDEFNVKVFRAGAYDQVPVTDINVGDIVVLESGDKIPADAVFLSGQDVKCNESSLTGEPDEVSKNPTKDPFLLSGCLVASGRCEVIITAIGVDSRWGRIKSKLVREHRATPLMEKLDEMVKLIGYGGMACSVATMVARVAIYATTSPENRHGSWVNQLLDTFIIGVTIVVVAIPEGLPLAVTISLSYSTKKMLNDNNLIRVLAACETMGNCTSICSDKTGTLTENRMTVVELWTQGKHFDEVAIKNPLTMDRRFFDILAAAVCVNSTAQLIEKTPSASLVAHATGDAKISGAPSNAPIVQGSKTEGALLLWLQIQGTKYKEVRDAHYRPSKGDRMFCFSSERKTMSTIVKRPDGSYRLYSKGAAEIVVTRCTHLLNQNGAVVPLNKITLHDIDETIVGMAKMCLRTICVAYRDFEPHELPKDLSKLTEPPESGMVCCGIFGIMDPLRQDVAESVEACLRAGITVRMVTGDNIHTAKAIAKKCGILTDDGLVLEGPVFRKMEKEKLIPLLPKLQVLARSSPDDKFMLVSLLRECQEVVGVTGDGTNDAPALRAADVGLAMGIAGTDLAKEAADIIIMDDRFASIKKSVLWGRCVYDNIRKFVQFQLTVNVVALTLTFLGALAGFDPPLNAVMMLWVNLIMDTMGALALGTEVPKPELLMRRPYKKEASLVSRIMLKHILVQAAFQLVVLLVLLFMGPSLLNVNKGNLCMSSTYSWKSDLSSPARSPCTTMLDQSTCPSLNCSTYVPIVTILNTSVTSPPNVPFDCVDSTCDEYDYRHFTFIFNVFVFGQLFNEINSRSVTNDWRVFKKFWSNSMFIFIIATTVVLQFLLVQFGGNFTKTSPLDAKLWAFSVLIAVLALPLGVLMRFIPVQENPNSFANPNSLTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XHF2</accession>
    <name>A0A6G0XHF2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Gamma carbonic anhydrase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_004643</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000062">
        <property type="protein sequence ID" value="KAF0739750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XHF2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000677"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04645">
        <property type="entry name" value="LbH_gamma_CA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047324">
        <property type="entry name" value="LbH_gamma_CA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050484">
        <property type="entry name" value="Transf_Hexapept/Carb_Anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13061">
        <property type="entry name" value="DYNACTIN SUBUNIT P25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13061:SF29">
        <property type="entry name" value="GAMMA CARBONIC ANHYDRASE-LIKE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0739750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="25467" checksum="73CBB5EE4DE99FD9" modified="2020-08-12" version="1">MIRKAIYEFGRAVRETGQAVDRLGLRVLGNNQHREKFSRHRQIMALYDKVPVIAHDSWVAPNASVIGDVEICNDSSVWYGVVIRGDLNKVSIGNRTNIQDRTVIHTSSTTNPGLTPGTSIGNDVSVGHGAILYSCTIENNVLVGMGSIVLDGALVESNSILAAGTVVPPGRRIPSGQLWAGSPAQYVRDVSEDEVADLAKQAAEYTKLAQTHSDEFLPYGTAYLHAESIKEQGGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XI44</accession>
    <name>A0A6G0XI44_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G10 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_004625</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BUD31 (G10) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000061">
        <property type="protein sequence ID" value="KAF0739817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XI44"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010292"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001748">
        <property type="entry name" value="BUD31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19411:SF0">
        <property type="entry name" value="PROTEIN BUD31 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19411">
        <property type="entry name" value="PROTEIN BUD31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01125">
        <property type="entry name" value="BUD31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00322">
        <property type="entry name" value="G10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="173"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="183"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0739817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="239" mass="27656" checksum="F57446C63B6C8278" modified="2020-08-12" version="1">MSRFTKKGRPPPGYEYIQPVMDALESELREKTTDPHEGLRKCEAMWPIQQINWQRSRYVYDMYYKYKKISKEVYDYCLRMKLADANLIAKWKKPGYERLCSTFAINTKNYNYGTVSICRVPRQQLADGQLVQERHSGCRGCASGPGGYHNIFGNKYGQYLAAIQIMRERRGAEESENVWAQNEADDVSDTGEDADDTNEDSAEDANTAQDEDEEERKSEPTGSDNEEEEEEPKVKRRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XIW0</accession>
    <name>A0A6G0XIW0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_004283</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I NDUFA5 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000053">
        <property type="protein sequence ID" value="KAF0740282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XIW0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003914"/>
    <dbReference type="OrthoDB" id="286811at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006806">
        <property type="entry name" value="NDUFA5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12653:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12653">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 13 KD-B SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04716">
        <property type="entry name" value="ETC_C1_NDUFA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0740282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="118" mass="13583" checksum="5A086C9127062058" modified="2020-08-12" version="1">MFRATRALSMAVVKKTSTGLVGLPVNPNWRNDLIKIYGETLKATQTHLPDCHYRTSVEQITNFRLKVVTDNEDENKVEALINCGQVEELIEQAEDELFLIPKYAEWRLWEPPVAPKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJ42</accession>
    <name>A0A6G0XJ42_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_004286</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000053">
        <property type="protein sequence ID" value="KAF0740286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJ42"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004152"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43102:SF2">
        <property type="entry name" value="GAF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43102">
        <property type="entry name" value="SLR1143 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="75"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0740286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="835" mass="93652" checksum="95516A9EF79F1A5C" modified="2020-08-12" version="1">MGRKLPFGGMLDEMNVSVDSLDVHAGGFDTNYSSDMFSEVPMINGMDEDDRTVFAAEDELDSSHQMIELREPLLLNRWEGYLLKRSDWVKNWDTYYFVLVGRVLYSYTSEDEARLQPDNSKIKLGKFTVNESVVIDEVLTVRSSFHYEFIFETEKGKRIHLRAKNEASKQLWMHMGCNAIVDAEIAQDPALGLRMPERHASLVDFFLGYEYLFASLSTLEDRAEILYNVKPKKKDARAVVLPNAPIADFPPKVDHILNRFFSMCRPDVAMRNNYLPMVPFQGTYRGYPGLLEYFTKLSKAAAFKSFKVEGMSFEHADDKRLVVVKGRESMEVRGTGHLLTQKWAQKFLLKDDGTISRWEINGDDVASSVAFKHLNTHATKYRESFTTIRLQDIPNLQRKNTDTFEGESRETMSHPTVRPSITTRSWWDDGPLSAKSHASSQWDRPQPSSKSRMTRQSHSHASSSSSYFDDEEDDVDSPAHDGSTQYPYQPSGQKDHFYPEPTTGADSDDEDASAINSNTANVDPSTFTTPESSSRAIKPEADFVDKSSVHPNLVQSFHDEKTVPPVKTPVRETASFHLPPQVLYRPNEEHAVLSPGIRSFYEPHTYHGSSVKNTQRGMPANYPSSNASTYGGDAITSSTTFDYSLGFKKGNLWPDAPVPLTEDIRLDTAQRLDLCRPRADLTMYLNIACKTLHCPSGSVCIVGGGAGLFVAKIGIQADTVPRDICLESHVIMSMEPTIVLDASLDIRFAMNPLVTGEASVRFYIGIPLVSDSVVVGALSLMDNAPRDMIKEKDFHSIVQIAQTIVHRVEDLSAAAAPSMPLSSFERRKKMDMEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJE7</accession>
    <name>A0A6G0XJE7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_004218</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000052">
        <property type="protein sequence ID" value="KAF0740485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJE7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010441"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0740485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="304" mass="33839" checksum="97627ABF7A520F1C" modified="2020-08-12" version="1">MAQVGGEWYLDEAKLLGAVSRAIQGYKGKVAERWHVIPIAFKTFSTTQANLLSVTENPQVNLVTRDERSGGFVALLDDTALNSRLARLRDVSNDVNFDYFSIMGGFTQLAFDVEDSTGTRFQFEMLYNEGSVDANTGFFAVVYNRKTGTEVAHCVVGGDIETAIKWVDHTLLERFKPHEGLCPPTQNGHLSRHEVINGDKALHHEFFDSSLAYDGLHVTSGDSEKNQLELLLAVAAKLCNQEEAIFFPKIVPNEVLAKAKTVYLNQTLSPLLASDACGPTGQFLDDMLFLDHDVQFRDQEDWDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJI3</accession>
    <name>A0A6G0XJI3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nuclear transport factor 2</fullName>
            <shortName evidence="2">NTF-2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_004282</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000053">
        <property type="protein sequence ID" value="KAF0740281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJI3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003913"/>
    <dbReference type="OrthoDB" id="6507044at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00780">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000005">
        <property type="entry name" value="Nuclear transport factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045875">
        <property type="entry name" value="NTF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12612">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NTF2" evidence="3">
        <location>
            <begin position="6"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU369002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0740281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="120" mass="13638" checksum="200AE101DA5E0669" modified="2020-08-12" version="1">MSATDIGNQFVKFYYDTFDNNRAGLSPLYMANSTLTFEQATVQGQQAIIEKFNTLPKTQHKTDTIDIQPSLNESSILIFVTGKMIIDSNPPLQFTQVFQLVAHQPGQFYVHNDIFRLIYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XLN6</accession>
    <name>A0A6G0XLN6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_003474</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Putative oxidoreductase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000037">
        <property type="protein sequence ID" value="KAF0741364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XLN6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010593"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44196">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44196:SF1">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0741364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="26947" checksum="18F91FB1F02B22A6" modified="2020-08-12" version="1">MNSMSGHTVVFTGGASGIGLALAIRFLQSGNKVILVGRRANKLNEAKAAHPDFHTVVGDMTTPESREALFLLLTTQHPDIDVFVHNAGIQRAVDLKEGLVSDWKTVSSEIDINYAGVIHMTMLWIPHFLKKPFAAFITVTSGLSFAPLANVPVYSSTKAALHSFTWSLRYQLADTPIKVIEILPPAVDTDLQAPGLHTFGVNVDEFADAVYGRLSAGEDEIGYGLAETGRVAFRNAFGASFSGLNAQFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XLX8</accession>
    <name>A0A6G0XLX8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Core-binding (CB) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_003555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000039">
        <property type="protein sequence ID" value="KAF0741221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XLX8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011981"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0741221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="23796" checksum="BB8623839C059F88" modified="2020-08-12" version="1">MSDLSGFTVEAARRNRISEATRQGYTSGINQVIKWAKLVGKDNLVMMTSGDECMETLNLRVFLYRDFLDFIVWVIREKSVQVGTLNSYRSAVKSLYKDQNIDLPEEYGEDMKMIFCGIRKTVAQNLQSGDKNFTGKRPLKFLDYESLCKESLALSDSGFTHLYLILSWNLMCRSKSTETITFDHISPQNDAIGFTFHKTKQPKMVARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XM01</accession>
    <name>A0A6G0XM01_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_003425</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000037">
        <property type="protein sequence ID" value="KAF0741313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XM01"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002121"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000019">
        <property type="entry name" value="Nuclear inhibitor of protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051858">
        <property type="entry name" value="WD_repeat_GAD-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16017">
        <property type="entry name" value="GASTRULATION DEFECTIVE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16017:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="FHA" evidence="6">
        <location>
            <begin position="44"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="260"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="361"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="192"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="732"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="227"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0741313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="759" mass="83192" checksum="F663EB86475B8A81" modified="2020-08-12" version="1">MSSRFPTPKWAGFPARANAKAYLEVWKDGEKLKDQLGIGQQACYVLGRNTDVCDFELAHPSISRQHAALVHSKTGTVEILDLDSAQGTVVDGEPLTKESNRKTLSNGSEIVFGASTRKYIVRGLNQKAPQSTDSVPMQLGVNDLPTGFATNNAKQSQKDAERKAREEEIRRITMEMMGQAPKVVREPQVPVDKFDEPEEPPRSQPPSEVRKTATVKGPQRPPSQQEVDSDAPESDSDDDEDNGSDIAMRYSLPLKNQVMLSAHDKLISSIAVDAAGARVATGSVDYHMKLWDFAGMARQVKPFRDAEVEEGHPVLALSYSPTGDRILAVTGSSQPTILTREGVTELQFVKGDMYVMDMAHTKGHTHSCTSGMWHPQQKQSVITSSLDGTIRLWNLEGKTVFDKLINDHVIKLKTKQGRRTEVTTCAYNHDGSLLFGATTEGMVYGYDLRRAYSTNATIKIEAHAAGSPDLSVSSIRFANDKIFGTRSCSDDCLKIWDIRRPSKPVKIFSNVSNHFATANLAFNASGTAVAAGTSVQAGKGLHGQVIFYDVLTAMQDPLMTTDMNQDESAVCVAWHPKINQVFVGSSASTVRVFYDEAISTKGVLLTATKKLPLVSSGYVRVDATGDGVIITPHALPMFRDANEKNNKRKYAKTRLDPIASKKPTMPISGPGFGGSTGGGTLTQYFMKDHIKSESIRSQDPREAILKYAKVAEDESVYLGAAYAATQPKDQIAPEYQLAKDTLEQEKIKQEEETRRLLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XNS5</accession>
    <name>A0A6G0XNS5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial splicing suppressor 51-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_002801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000030">
        <property type="protein sequence ID" value="KAF0742129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XNS5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000213"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046824">
        <property type="entry name" value="Mss51-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28069">
        <property type="entry name" value="GH20023P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28069:SF2">
        <property type="entry name" value="GH20023P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20179">
        <property type="entry name" value="MSS51_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mitochondrial splicing suppressor 51-like C-terminal" evidence="1">
        <location>
            <begin position="33"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0742129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="260" mass="29480" checksum="66FFDD24A4E0ADDF" modified="2020-08-12" version="1">MSSPWLNPPNAWEETPFAASLSNDLTNQHSRSLTILKALQRLNLLVAKSNAFKRKHKLPNEVDSPMRLVLHIVGADFREGNEVAETLQVFEHLIALFHASQASSKATDHGYAELVLVMIGPNVARKLHGKDERIELSPGKSLRLIYATEIWEEHLVSPTYLSPTAIICFNAGVWGYDEWLPTFQRMMREEPLAPIVVTSYNEFEAIDDEDAIADVEMPLIWHWRHEPNPFASLAPRASQHTIADRVLHENSQWLCFGANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XP65</accession>
    <name>A0A6G0XP65_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycine zipper domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_002980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000032">
        <property type="protein sequence ID" value="KAF0742045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XP65"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005245"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026222985" description="Glycine zipper domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0742045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="150" mass="15248" checksum="802349D28141148E" modified="2020-08-12" version="1">MRVLAPLALATSAVVALNLRGQDAPVESSNQEVAPMHSPDDLRILMDIQEGGSPRSPRQSNQRHRGPKETKYREKGGKWGAAAGAVALGVTGTVAGSLAGPVGAVGGLSGGIVAGGFGGQALGKAVGGAYGRRQDKKDQRKALRRSATIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XRB0</accession>
    <name>A0A6G0XRB0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_002239</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="VJMJ01000023">
        <property type="protein sequence ID" value="KAF0742842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XRB0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016346"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000025">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase CYP19-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF553">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0697">Rotamase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="75"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0742842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="240" mass="26367" checksum="1F4CCA98BC2EF682" modified="2020-08-12" version="1">MGDRTRGKDTAFMIYLVAGLSLIVVFFIATMQDGAISKAVPAASPVLLGKGPATEPAPTLAPRNWTRQRGRRYVWLDVAIDDVPIGRVTVELYMDIVPKTAENFRALVTGDNAVGVSYKKSKCHRILKGFIVQCGDYEYGKGYGGKSIYGDTFEDEKAGLALKHDKRYILQMANYGPDTNKSQFCFMLGPAPHLNGHHVVFGQVVDGFFVIDKMEASGVKTDQDELTHKVILVDGGELFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XST1</accession>
    <name>A0A6G0XST1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flavoprotein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_001727</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000013">
        <property type="protein sequence ID" value="KAF0743583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XST1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019742"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071513">
        <property type="term" value="C:phosphopantothenoylcysteine decarboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="entry name" value="Flavin prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359">
        <property type="entry name" value="HOMO-OLIGOMERIC FLAVIN CONTAINING CYS DECARBOXYLASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359:SF6">
        <property type="entry name" value="PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="Homo-oligomeric flavin-containing Cys decarboxylases, HFCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="4">
        <location>
            <begin position="94"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="39"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0743583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="288" mass="31211" checksum="B301E9555E4608E2" modified="2020-08-12" version="1">MKIVACVEGGMSHQAAANEFGISRTAVTKMVKEKDLIAAKHEQPDLKRPRRRAATTDSEDAASSEADRKTSKSDVKNLIDAVHVLSAKRTTRPRILLAASGSVATVKVPELAVKLSAVADVRIVLTKAATFFLAKASAYNPDMYEQFQTLQLEILHDEDEWGAWNSMGDPVLHIQLRDWADILCISPLSANTMAKLAHGLCDNLLTCIVRAWSCRKPLLVAPAMNTQMYLHPATGKQLGLMREYGYDIIPPVCKTLACGEIGNGALAPVETIHDAILAALKVPPGHAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XSU6</accession>
    <name>A0A6G0XSU6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_001364</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XSU6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020896"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="117"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="288"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1063"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="477"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="626"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="702"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="883"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="317"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="331"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="354"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="367"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="385"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0743705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1097" mass="122458" checksum="B34F9B9FDE7E85B6" modified="2020-08-12" version="1">MTGTASRSLYGNAYRPQVPSAGAASNGSHRSNSLRGHQATPPYKHTDKDEQLYNLVSDLSNACRNDSNANALKDFNLIETLEKSAKDILARRNNQAPSPETKTAAANDLIQKRRRLSIEGKSDDDDDDPSGPRFQKIERPAADTSSAAPKRYNMPTFFSAMPRQASNGSVPPSRSPSPLLGKDNEAPLKTKSLPQKPALAPPAIFQDFSDPEDDEPSFMRDTISRDTFSRETGIYSRREALCMDDLSLDEINMIAPSAQEDLHRKRGHGDISFTQAKDDDIQSIMDKAKVSVNPDNATNSLRKKPEKEPEYTYTHMGSKLKSSRVRSGSGSKDRVRRSSQEDKKSITDAKLISINKTVGSTTPTNGSLQSSRAQLRSQTMLETKSTSWATSSTSSASSSTFKAPEKVKSVEKPISSFKPAPEKTVAAPVVEVTRQKPTPVRREVSLDDDMHESTKSYQPAPQIIEKPIVPADILKKIETLEKQLAQKTDECARLTTELMSQDTQWKTQFEASETAYKALEASVARLTAEKESLANQIADLESRIPSGDSTSNRIVWHLKEILREEEADNKIETARATKIAALVNRFEKSNAQVQADFAQQLRHEIKTIGITRSASLSVDSNNRVTTSELEEKIAEHEATIEALTREAQNYQNQLEMALQTAADRDQDVMQLEHKLSSLQVTPKDATVQAVGVQKARKLEDKIALLESAALQRDREKERLEEQVRELQRSLDGKSREDTKLADATRELEAQRAEVARLQQALEAKTKEFSAPQEISVMRDSFVRAKSVHFEDDDADSITLRTKLEKKEAEVEEMRAALYEKTCDINALKQEVMAKTETITHLSADFAERLETFTKSRRDSSGAPSDPEMEKMEMFLFNQVCAKQQEIDELIEELERKDQELQELAQQVEATRGAADTSALEAQHAELSSQVKLLTEQNSLLKQETEVQSRSIESKQRQIKSLIEQMQAKEAELSELDEALATAEMQVEHLKQQYNASFTQEEEESFAAAYREGGRRSSFSLRRNSSASLYSKPTSAMDDGYDEYERPMDNLSVESGTSYMTKGSSAFEDDFAGSPRFSSLSPGRDSMVSRSSEWGLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XTN2</accession>
    <name>A0A6G0XTN2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="6">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_001385</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="6"/>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XTN2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021266"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016971">
        <property type="term" value="F:flavin-dependent sulfhydryl oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039799">
        <property type="entry name" value="ALR/ERV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645">
        <property type="entry name" value="ALR/ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645:SF0">
        <property type="entry name" value="FAD-LINKED SULFHYDRYL OXIDASE ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04777">
        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="FAD-dependent thiol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0274">FAD</keyword>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="7">
        <location>
            <begin position="38"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0743729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="164" mass="18547" checksum="CCC8DC55E3A6C8F2" modified="2020-08-12" version="1">MTRADPNCAEPVCDSKTDMFRSGVLGKKKKHGKTPLECPLDREELGRASWGLLHTMAAYYPENPSDVDKARAKAFVDSFAQLYPCKHCAADFQESIQVIPPRVNSRIDFSLWMCEQHNRVTTKLDKKPFPCTIDALDKRWKTGVPACWAKKEDEITAEESLGQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XTW7</accession>
    <name>A0A6G0XTW7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_001343</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="VJMJ01000011">
        <property type="protein sequence ID" value="KAF0744080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XTW7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014648"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015357"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020150"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase RNase H-like" evidence="8">
        <location>
            <begin position="666"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0744080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="878" mass="97641" checksum="50CE93FF8907B9F6" modified="2020-08-12" version="1">MHLDNEGAVAKAVTSLLGRPAEWAHGQLSLNSNCFPDLDTFFAALKAFLAPPDSDFRNRTLFHKSVRGKLSIRDYANRLRYIYTLMIDRDSLNEATPVSVFMNGLVESLLRSELFHRIPKTFEEAVEIALKEEFSQASAQGKSAGSDQWDMEVSSMEQFPQREAYRVPASAPPSQRPCFECNQLAARLSTPQEHAPPTTSEDALPSACASKTSAVAASLWKIPWLEGRPEPRLAPTGRDKAFPFDDGGSGGIASGTLLCQLGQSSRMLSFEMSIAGFSRPLKVLIDCGASENHARRETIASSKAMLDRATSDQASHAKVRVKLANGQVIVTDRVLITQPTKIGPFDSEETFFVIDLDDRWDLILGMRWLEKHKPTIDWCSKTLSAPSSSDDTPLGVMSNELTPSSDLKTQLNTRSRRTIEESIDDDVLEYNSIHAVSATTEASGELAETRNVSVLYDSVAITARNTARNKVMFQELEGFGISHDGITKIYASHDAKRRRLRMARAAAWSQTLAEETILPARVADTAVRLTADELILSHCDLEELPRVGEEIVKLPEMSFREFKRAIRSGDIVSIALIQPVDELELNTSSTLDTEVASGKTASYLHKFSENFASIARPLSTLLSKDEPWNWTQDCQAAFDGIKASLVSAPILALPRFDRPFSVVCDGPVSFQSRQLRAAERNYPVHDLELLAIKYVLVKFRIYLLGSKPFVVYTDHASLRYAVKTPHISEHMAPWFSFFAEYNVTVEYKPGRENVFADALSRRPANLGPETTELSVVYHVHSDLYDRIRRGYRNDPAMKAIMAQLSGTTSRSGPTSTLERYSIRDGLLFHQLTRTTTPRVAVPCDADLCSELVKEFHDTPSGGHLGRDKTHVTLARSFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XVR1</accession>
    <name>A0A6G0XVR1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">phosphoethanolamine N-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.103</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_001046</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N,N-dimethylethanolamine phosphate + S-adenosyl-L-methionine = phosphocholine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25325"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58641"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
            <dbReference type="EC" id="2.1.1.103"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:25326"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N-methylethanolamine phosphate + S-adenosyl-L-methionine = N,N-dimethylethanolamine phosphate + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25321"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57781"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58641"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.103"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:25322"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; phosphatidylcholine biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.103" evidence="5"/>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XVR1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009458"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000234">
        <property type="term" value="F:phosphoethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44307">
        <property type="entry name" value="PHOSPHOETHANOLAMINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44307:SF2">
        <property type="entry name" value="PHOSPHOETHANOLAMINE METHYLTRANSFERASE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase" evidence="9">
        <location>
            <begin position="93"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0744577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="313" mass="34098" checksum="E86B167336F3BD1A" modified="2020-08-12" version="1">MKVPSTLASLAVPAACFVAGYVAHYILNRKPRASSRYHLDPTLACLTKHQSPITQTSTWINLGLWTSDDLSFPAACEQLALRLGQAARLSALDSVLDVGCGRGDQCVLWHDHFKVAQTAGIDITPEHVASAKLLVEQRHLSSSIEIHHASVADLLTLDVIKTKNVTKILSCDAAYHFTTRMDFFANAFALLQAGGMLALIDIVVSEEVLSWKGLDHIQLRGLCSMASIPFENLRTPAQYQADLESAGFVNVQIEALHEVASGFASFVARQSHQLGEWSLGADFEKFEMVGAVLAACAQHKYMHFVVATGEKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XVT9</accession>
    <name>A0A6G0XVT9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_001074</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XVT9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007651"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000997">
        <property type="entry name" value="Multidrug resistance-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000163">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="628"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="672"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="778"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="869"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="892"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="50"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="348"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="685"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="958"/>
            <end position="1185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0744607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1192" mass="131297" checksum="84BE64C49A7C88B9" modified="2020-08-12" version="1">MEHDVWDLPYNQTCAGFSDRFNLAWATVRGSRLVPRFNVALVKCFLGEHLACLGSQVIATLSLVVQPLVIQSFLQYLQGEPISMGISNGYALMALLVAATSLQTIFLNYAFFIEAKIGVSMRSVTMDMVYQKPLKLSSSARQLTTSGEIVTLMSSDSERICEAATDGLWIIVSPFTLFCAVALVGAYFGGWAALSAFWSDGVCPHCLGVACHRHRLTTEILQGIRVMKFYAWEPAISHRLTLLRQKETRFLRRLNLLRVVNVEFLFLAPVFVGAAVLSTYIGLGNAIDSTQIFTLIAFVNMSRQALYNCPRTIAGISEGIGAGRRLDIFFDLEEQTPPAMLPIASGTIRFQSASLAWQSTPPICLSNLNLTIAPGSLVMVVGSVGAGKSSLISAILGEMHLVQGSVDVHGSVALVSQEPWIRNDTVRGNILFEDAYDASWYKTVLQAVQLEADMRLLPAGDKTEIGEQGINLSGGQKARVNLARALYKRESNVLLLDDPLSAVDVHVAKAIFDQAIEGLARGKTRIMAMNSHYQFLQRADRIVVMENGSIVGDGTFAELYSAFPQFLNRPSDKAKSTDETFLDENVPKAHAMMEAPHRASEVSAVEDDTAVLIIEEDRAKGIVSKKTYFDYFGHVGFNGWVVSFSLVFMFAFGQTMGVAVDWWQGYWAARYYAVSVATYHGVFYGFVVATICFFAGRCGLLATYTSRCSENMHNQLLRCVLRAPINLFFDVTPVGRILNRFSRDLDIVDSLLPNLFLDILQTFFIAASSMLVCAVSSIYVALSFLPVIGPFYVMGEFFKKSSRELKRLEGVSRSPIFSSFAETLDGVQTIRAFKMDRHFIRQNRKAVDTNAKFLFALVGVGRWFSVRTYLVSVLLIAIMLTVIINIRHSISATTAGLALTNSLALLPMVQWFIRLYDMVESAMTAVERLLHFKTIPEEAPETTLHDPAFASWPSKGAVQFQNLKLRYRPDLPLVLHGITLDIQGGEKIGICGRTGAGKSSLMIALFRISEFDSGTILIDGMDIATIGLATLRRVLSIIPQDPVLFSGTLRENLDPFGEKTDAELDAVVQQTHLDLALSTVVAESGSNLSVGQRQLLCIGRALLRQSRIIVMDEATANVDLATDQLIQTTIQQAFTTETVLTIAHRLDTILHCDRVVVLEKGQVVECDAPSVLMAQESSAFHKLAKEASVLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XWC7</accession>
    <name>A0A6G0XWC7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_001223</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XWC7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010736"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000528">
        <property type="entry name" value="ABC transporter G family member 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="376"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="454"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="490"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="514"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="1"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0744769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="582" mass="65324" checksum="C5DC1ED4C1EDF692" modified="2020-08-12" version="1">MTGVLKPGTITLILGQPGSGKSSFMKALAGSFHTTKTNRIEGSITYNGKTKKELDRRLPQFVSYTEQRDHHYHTLTVQETLAYAHQFAGGVAPQHVLDALTNGSAEENAEAKKIIEALYAVYPEVIVQQLGLNNCKDTIVGNAMLRGVSGGERKRVTLGEMEFGMKQVSLMDEISTGLDAAATFDIVKTQRSAARQLKKTIVISLLQPGPEVFDLFDDVIIFNEGHVMYHGPPASVLSYFESLGFRRPPHRDVADFLLDLGTAQQDQYAVASAASVPRLPSDYAVLFRESSFYRDTLSYVNSPTHPKLISDAANHMAITPVFYNSFVANIVLLTKRQLTVTLRDRAFIISSIVMAILMALLYSSSFYQMNPQQPQVVMGVIFQSLLFFITSQVPKLPIIIENRKIFYKQRDANFFSTLSYVVAHALSHIPFAIVETLLFGNIMYWMAGFVNDGMAYVTFMFMLFLVSFVFSAWFFVLGCVSSDVNVAQPLSFLSVMIFVLFAGFIIVERDLPDYLVWLFWINPVAWIMRGLAVNQYSVPEFQVDVYEGVTYKTIYNHTMGDTMLNTFDVKTDTKWIGYAFCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XWW2</accession>
    <name>A0A6G0XWW2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase M20 dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_000560</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">The Mn(2+) ion enhances activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000003">
        <property type="protein sequence ID" value="KAF0744976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XWW2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001815"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03886">
        <property type="entry name" value="M20_Acy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.360:FF:000001">
        <property type="entry name" value="N-acetyldiaminopimelate deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014:SF63">
        <property type="entry name" value="METALLOPEPTIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G09600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PEPTIDASE M20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="4">
        <location>
            <begin position="191"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR005962-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0744976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="403" mass="44246" checksum="62D5CCB1A173F0C9" modified="2020-08-12" version="1">MGIEDVLREFRRELHTFPELGFKESRTHRRIKEILTQHAGIPEEAMKPCAGTGLVIDIKSTSTVPTDSKTGVSCVAFRADIDALPMTENNPHLPYRSQNVQCAHMCGHDGHTATLVGLAIVLYPRRHLLPQGTTVRLLFQPAEEGPGGARPMIADGCLDSVDEVYGYHNYGFPLGNLHVRTGPIMAHEQEFTIEIQGKGGHGSAPQLCVDPIIIATQVVNALQTVVSRSLSPYASAVVSVTTLHSGETTNVIPSAATLGGTMRDFDLAVAKTLRTRMEAIVHDTCHMHGATGIVNIHESYPTVINTPEQTKIVQEIASSVFSTVSEDGLPMMAAEDFSYFLQERPGCFFFLGTKEQGEMQHRDLHSDTYDFNDKVLPLGVQMFVKLVEHRFACEILSDWANVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XWY9</accession>
    <name>A0A6G0XWY9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_000627</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000003">
        <property type="protein sequence ID" value="KAF0745050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XWY9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005306"/>
    <dbReference type="OrthoDB" id="72593at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0745050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="205" mass="23138" checksum="5189B95BBEEA5D38" modified="2020-08-12" version="1">MYIGPWQEYKLAKIQDAAVQKLRQEWEAHLKSTLVAPQDGEDERIRQMMEPILAKLPSMLLSNRAKPSSQASQRATKRSIRPPPPNNQESIQERRVPPKAISKQKKAKTPLSSIDAVARRRQMWKEPTEPRVEEPVRLPQVAPPLEPSVAVSGPPTAAIKEPVHLPAIIAQPEVDEDSLDEDELNSFLNWTDQLAHPDMDEFLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XXD3</accession>
    <name>A0A6G0XXD3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_000250</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XXD3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002221"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006585">
        <property type="entry name" value="FTP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF408">
        <property type="entry name" value="OS09G0560450 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22633">
        <property type="entry name" value="F5_F8_type_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00607">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="93"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="129"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="174"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="210"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="5">
        <location>
            <begin position="825"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="5">
        <location>
            <begin position="883"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="5">
        <location>
            <begin position="940"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="382"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="384"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0745217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1280" mass="145609" checksum="559ADF2C21B8064E" modified="2020-08-12" version="1">MGLFKGCWSPRKVSTQVYADGPNSNVDPTPGKPEAKNESMKKKLTGGDAMGDLDLFGEDSDDSDDEAAIERYDRDDLDKDDEEYKERNVDLLLAKMTPEEMFIKFDEDQSGMISRDEFVKMLPQLGIKLSNAKAIRIFDSCDKDGSGEIDLEEFKMAMFAVDPNTGNTLGFAPSSLLTPKDAFHLFDSNGSGKLDELEFADALEYFGMDVSDAKQEKLFHKYDTDKSGFIEYSEFRAMWLQCADLKHELMSRGIEVPKFTTRTALMQNLANILDEEERREEEAMEEAKWFHHWQLERLRRVELARKAALRAQDELAAALDAAGQVYMLGPGQYGEFKGDPASRDELLFDRYTHVSEIWQSRVFPTYTPPEFKLKQALFSTAAFEEPRKTEDDTPRNPDLMQRKHSDQTRKEPTNEEPPKERIPFMRRRNENIQYDANHESPPKLHRQTWKPKDIVPVVRPESSTSEQSEQSELEELNKKFLEDRMYVRSLRFKGMHIMTNTGWLWGRQVIQAALSDSVAYAVTSSGQIYCWGGKNQWWKGIGIDKNDEDDDETEDNTKEDAEKMRVLTSRSELLKMAAPKYAAAAMRLELEVQRQKQEMKRQKDADDEIQYEKYKRVVLYFDLWDPPPSFSTRLIFMKQVLLPKIDFSTIKASLTNRGYAIDRATKQELIDLMSECLETEALLCTEEVRRGFKEKDFVIQQTEAARAKLKSKKFEEIPEKAILFTEYERVKLEQEQRVVRMKLQSDEDRRLLALKKEDAFEASVARRRIEMEDMCPEFTPRNSSLIIELNGVTSRGPPLHSPRGASAVWKISAGENYACAVTHNGSLYSWGVGISGRLGQGTTMEGTINADFDRPTRVLALKSTYIQDIACAFDHSAAITVDGQVYVWGSTSTGKLGIGPQDAKYEQFAIYPVRLNFPRHRRVRQISCGRAHTGAVTTDGEVFMWGCANGGRLGLGENVQDEVTVPTFVKSLAHVRVARISCGNCHSAVCTDIQSTMDNTIETLTGGDVYMCGSAGPLLHYTPTWSIVQKLRGLPVKEVCCGFGHTAAVTYFGELYTWGQNIDECTGHPADRRVIQEPELLRAFHVAPYNLALRKPARQSSVFNEQDADRAVDGNKSGQLHTCNHTQFDDHPWWEVDLGQPSVIERIKVWNRTDQPTDTSRRRDEYTSRLFPFWILVSEVPFSDAVGREGLKAGRGHCNASAEFTQDVRVTEWVLPTTSTVGRYIRIHVKGSRYLHLAQVEVFGVYNAFNYVGRVSSVHCAKNVTLVVMRPLTMHYTITT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XXV9</accession>
    <name>A0A6G0XXV9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GRIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_000421</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XXV9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001272"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18921">
        <property type="entry name" value="MYOSIN HEAVY CHAIN - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18921:SF2">
        <property type="entry name" value="THYROID RECEPTOR-INTERACTING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="48"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="234"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="413"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="482"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0745402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="602" mass="68205" checksum="706D841EF856633C" modified="2020-08-12" version="1">MWDTIAANVASYGKDLTQDIREIVTGVEREEEESKAIAPQDEDLEAYVIDLERSLIRKKQEVDDANKKIELLEAKLKQIEQHADDLQPHTERLKSLDISEDAANTALTDAKRDIERLELDCSQLRARLANSDDFDKSSGIVAKPTESDNDELEQAAREGVASLAQVLTSEDLNGAAIDPLPGKLVKYISLVTSRLIASEVDTKALKNTLHAFLLAQNERFESQAFSLPECKLKLEGILQQRRDSLQRIARLEQTNSQLEQRVQEAETARREWQHAHTDAMNDLKTTQEMLNAARDASKADKDDSIRKLQDKLQQMQRNTLHLSEELEATTQELQETQAALAKQAETLKEEMEDSQHAIMDRNIVLERKVYELTDELARTKEAHDNERVQWTQHVQVNTSSVTEAQLFELTTRLSLLEADKNLAEQDADRLQTELANLNEVLIQFQHDRVNEEAQWRAKVQALEIAATEKQQDTSNAISLEEHKTILSALAKKEEDNERLREALERTTVQLLADNDSVDKRMVVQMMLQYHESSNKTDILEVMGRILGFTEEDKERLLSHPGRIKGIPMLGSIFGATPAPSSVDVSGKSFSDAWADFLLKETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XYD6</accession>
    <name>A0A6G0XYD6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_000216</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000001">
        <property type="protein sequence ID" value="KAF0745768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XYD6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000419"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904:SF523">
        <property type="entry name" value="STRESS-INDUCED-PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904">
        <property type="entry name" value="TPR REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="5"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="196"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0745768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="233" mass="26277" checksum="CE8895CA1BD93AEA" modified="2020-08-12" version="1">MADAAENEKNLGNEEFNAKNYDQAIHHYTEAIKLAPNNHIYYSNRSAAYGALNKWEKAEQDAKECVRLNPSFKKGLLRLANAQRQLGKNDEAMATMALANGGSVPAKRTKQETSAPLPQSVQKELQELQPQFQSLHRELETIESKLGTFSREKKRIQLTKEELAALPSDTRTYSSIGKMFLEMTPEENTARLDGNSRSMDDQIAALEARKQYLERQKVSLESNISELLAQCKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XYJ7</accession>
    <name>A0A6G0XYJ7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_000112</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 81 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000001">
        <property type="protein sequence ID" value="KAF0745660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XYJ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013764"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052861">
        <property type="term" value="F:endo-1,3(4)-beta-glucanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005200">
        <property type="entry name" value="Endo-beta-glucanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040720">
        <property type="entry name" value="GH81_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040451">
        <property type="entry name" value="GH81_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31983">
        <property type="entry name" value="ENDO-1,3(4)-BETA-GLUCANASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31983:SF0">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-D-GLUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17652">
        <property type="entry name" value="Glyco_hydro81C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03639">
        <property type="entry name" value="Glyco_hydro_81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52008">
        <property type="entry name" value="GH81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026072890" description="glucan endo-1,3-beta-D-glucosidase" evidence="10">
        <location>
            <begin position="19"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="942"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="975"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 81 N-terminal" evidence="11">
        <location>
            <begin position="39"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 81 C-terminal" evidence="12">
        <location>
            <begin position="332"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0745660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1000" mass="108708" checksum="D51DEA383D98F0FF" modified="2020-08-12" version="1">MGRFALVVVVAVACVVHAFRYTNVTHSLQEPLKKLHPDLRGTPFPTQAFWANFVLGQGVDVVVSYPYTVSIQKNQLHISYPFRVVTSRSIIEGFTSEIIVELGTQPLQVRRFDELSVTVEFPQASGGVIALHLVRGSPYITLEFHGAAPTISSSINIVSLTPASNYTQATLGNWHQWLLFTSSPFTWTQQGKKWSGPSNFDGVLRIALALHENTKPILAAHASVYPVGASIAFKPTNETNADVTFSWQTRSFNSTSPASLLMAALPHHIDTFSANQAFAPEIQFMCMRGPMKGVLGDVWTFHEPLTDVPWDYPIDGVFKSPTSPEYNTTVEFIRTSLDKDIDRFPAFAEDSYNFGKQFGREARLVLTAHRFNSTTAFTKGLTKLQNQIAKWLTGNNTNHFVYDTSYGGLITLHGYQSEGEDFGNGMYNDHHFHYGYFIYGLSVIRRFNESFIHEHQEAIQYILSDIGSPLGNSSSFFSTFPQRKLFPTARHKDWYCGHSYASGLFTQANGRSQESTSESVNAYYALALFASLDSSPEYFNYARLLLATELRSSKTYWHISSSQSPTIYEPAFAGNKIVGVLSEIDAVYSTWFGDLPAFIHGIQTIPVTPITAYLLPASYVAEERAVLDGLPVISNPSDIWSSVLSLNIAIVHAKAEWTKVQTTNYNYDTWSSAANAMHWIASRPSFIVEVPPAVTSPPPVCFGYPTCALAGAFGSSLDCCKTLPGCCPSDNPCCNSDISPVNASNVCHDEPACGVLGLSCCDSPEGCCKPTPTGQVLGCCKQTTKPTAAPSLDTAQCHHQPKCAAAGLECCQFPEGCCVPTPTGQVLGCCESPNATTTAPPATSTCHNEPQCGLLGLYCCGTPEGCCNTPSGQPKLDCCSVAPAPKAHSVTVGDSGVSTCQANPRCLTAGPNGDALPCCKDAVGCCPGNACCGSNPWNVERILLIILGTLGLAGLVYCSVLYLRRKNYQPLEGDIRAWYCAGFALLTFGVFFYLVFTVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W3C5</accession>
    <name>A0A6G0W3C5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Senescence-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_019108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000393">
        <property type="protein sequence ID" value="KAF0721508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W3C5"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052997">
        <property type="entry name" value="RRT15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047">
        <property type="entry name" value="PROTEIN TAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047:SF8">
        <property type="entry name" value="REGULATOR OF RDNA TRANSCRIPTION PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0721508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="31486" checksum="60BAED98FF7FC03D" modified="2020-08-12" version="1">MIGRADIEESKSNVAMNAWLPQASYPCGNFSDTSSLKFKRTKGSRGHAFTVCIHTENQNQVSFYPFVLHEISVLIELTLGHLCYLLTDVPPQPNSPPDDVFHRYFTCAEAPAYSTPPKSFHNVRLESSSTGSSFPADFSKPVPLAVGSLDNDEAFGYLKRVIVTPAVYPRLVESLHFDIQSTGQKSHCVNTVSGHHNAFSELIVHRIHNSLQYNKGSPTNSPYRSPRGPTHSIVGHPSSPKRRLCPILRANPFPEVTDLFCRLPLSTFFYQLEAANLGDLMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W429</accession>
    <name>A0A6G0W429_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 12">Ornithine aminotransferase</fullName>
            <ecNumber evidence="4 12">2.6.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_018942</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:25160"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="EC" id="2.6.1.13"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:25161"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 2-oxocarboxylate + L-ornithine = L-glutamate 5-semialdehyde + an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:13877"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="EC" id="2.6.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.13" evidence="4 12"/>
    <dbReference type="EMBL" id="VJMJ01000367">
        <property type="protein sequence ID" value="KAF0721764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W429"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019321"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004587">
        <property type="term" value="F:ornithine aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019544">
        <property type="term" value="P:L-arginine catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010121">
        <property type="term" value="P:L-arginine catabolic process to proline via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000011">
        <property type="entry name" value="Ornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000152">
        <property type="entry name" value="Ornithine aminotransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010164">
        <property type="entry name" value="Orn_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01885">
        <property type="entry name" value="Orn_aminotrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF18">
        <property type="entry name" value="ORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0721764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="445" mass="49409" checksum="535CBA62DCF2CA64" modified="2020-08-12" version="1">MFAVRRSVVRHTRQLANSTRHKSAFAVSVDVSAENKHKLTSEQYMAREDKYGAHNYHPLPVVLSRAQGVHVWDVEGKQYYDFLSAYSAVNQGHCHPRIIKALTEQASTLTLTSRAFYNDVLGEYEEFVTKFFGFDRVLPMNTGVEGGETAIKLARRWAYECKGVPENQAKIIFCNNNFWGRTMSAISSSDDENAYGKFGPFMPGFDKVPYDDIDALRAKFESDKNIAAFMVEPIQGEAGVVVPRDGYLRQVSELCKKHNVLLIADEVQTGLARTGKMLCVDYDQVKPDILILGKALSGGVYPVSAVLTSDEIMLTIKPGQHGSTYGGNPLGSRVAIEALKVLEEERLAENAFELGNYFRSEMTKYTLDSSVCQGVRGRGLLNAIIIKERPGKPDAWDLCLNLRDKGLLAKPTHGNIVRLAPPLCMTKAQMDDCIAILKEGLADIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W4M4</accession>
    <name>A0A6G0W4M4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_018769</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000353">
        <property type="protein sequence ID" value="KAF0721988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018066"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018067"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24188">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24188:SF29">
        <property type="entry name" value="GH09064P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="26"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="26"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="30"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="63"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="96"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="129"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="162"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="195"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="228"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="261"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="294"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="327"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="360"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="393"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="426"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="459"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="492"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="525"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="558"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="591"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="624"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="657"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="690"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="723"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="756"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="788"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="821"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="1129"/>
            <end position="1376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0721988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1602" mass="177481" checksum="A70E3AF19000A891" modified="2020-08-12" version="1">MMFEAAEKGDVDSIRALLTKGASVNMTNENRQTPLYVASRGGHLEVVKELLAQGASADTRDKDGQTPFYVALSRGYLDVVKEMLVQGASVDAADKYRPTPLCVASSEGHLDVVKELLAQGASVNLTGVYGQAPLYVASRGGHIDVVKELLAHGGSIDMMNEDGRTPLYGASSEGHLDVVKELLTRGAFINTADKVGRTPFSVALSRGHLDVVKELLAQGASVDTADKHGHTPLFEASRRGHLDVVKELLAQGASVDTINKDRQTPLHVAARGRHLGVVKELLATGVAIDTADEDGQTPLYMASREGSLDVVKELLTQGASVDVASVDGQTSLYVASRRGHLDVVKELLAQGATVDVSDKYRLTPLYVASSEGHRDIVEVLVAHGASVTTRDMYGQTPLYVASRAGHLDVAKVLVAHGASVGVRNEYGQTPLYEASVQGHSDVVKELLARGASVDTTDEFGRTPLFVTVWKGHLGVVKELLTQYASVDTKYDDGRTPLFVASRGGHLVVVKELLAQGASIDMTNKFGHTPLYAASSEGHWDVVKELLAQGAAIDMTDEDGRTPFYVALWKGNFDIIKELQAHGASVDGTNQYGQSPLHVASSAGHLNVAKELLAFGATINFRYKNGCTALHAASRNGHLDVVKELLACGVAIKTRDKDGCTPLYWASLNGHFKVVDQLLICGAIVDVACWDGRTPLYMASGNGHLEIVEKLLSHGAALDMKAWDGSTSLQTALWQGHFPVVELLIHRGASVNISDMRGTTPLHVASISRNGHVDMVNLLLSHGADVGANGDLPLHCASFWGHLDIVKVLLVHCASANRINKNYCTPLHLAAKRRHLEIVQLLLSVCGDMNKKLKDGKNARDLGNQEVKKICDSFQERNLQMSMHSATMIIRKAMEDTSNETSKLFKVASSIFKLSIDIRLHRMSILSTSLILESVVRYLMIHRSSCRALGLFAVLQAIKTSWQNMHGKTNPLKMTLDNNQLGYQTTGAEIARLKDRLIAATKNLPIVSSFQVVGDEEDLKNNVPNLMDKINSLDTNLVTILSQLGRQQQRDGLVNLAVQMQRGVEHYKRQVNLGNMKRDDGMVRRFELCQNKITLAIEKMQCLQNLPQSFGFGNIESWMLSADDVQYDPNNLSTALGRGGFATVFKGMYHGETRIHPNWKRLLLMNIKAWKDISHEPYILTLVGVCTKAQPPILVSELCENNIRRYIREWPDALIPMIYQFARGLDFLHSANIIHRDLKGDNVLVTFQKTVAIADFGLSRSAESLKNTRTGNKVSGTLNWMSPEQFFSPRNMTIKSDIWPFGMTVWEILCNDTPYRRCSEFEFQEILKSEDDRPEKPEDLHPYLAPLWTLITNCWQLNPHARPSANDIVKFLESEYNAQDMPYQQESVGDSTIDADIFEMDEIDNTVTSLDQLIQHIFSEPSKPLSLLNNYVLYPKLIEATNQNIFKVRNERQPWKHLFVKLSEDSKEIDFYKSFADIDEATDYTVECFDSGEWYVCGYKCFALILQRGGEECESYLRSLFEDNTSKHKFIEQTVAATQFLHSKGWIHGNIKLENVAYFGSEERFKLMNMDHAQKINSEVTQYGTPENCPPEMASIFWAKPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W4N7</accession>
    <name>A0A6G0W4N7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Crinkler effector protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_018751</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Host cell</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000352">
        <property type="protein sequence ID" value="KAF0722001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W4N7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007208"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008636"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014290"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043657">
        <property type="term" value="C:host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045379">
        <property type="entry name" value="Crinkler_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20147">
        <property type="entry name" value="Crinkler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Crinkler effector protein N-terminal" evidence="4">
        <location>
            <begin position="2"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0722001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="952" mass="107706" checksum="6F92CDD2FA6CDBC1" modified="2020-08-12" version="1">MLTLFAAVVGDKFPFSVKIDASENVHALKKKIMEEIPYDGCAMYLQLYLAKTPDGTWLNSNDAKDVALDEEGNLQHYKMMNPTHFINRYFKATDLAEELIHVLVVVQDGEVGPVTGKRSNEEIGDILEERMSKFIKKGKKSEHLSTMDSIQKRAILDKTALNVRVLQMKEPIDESIPVFKWNGELAENQENQRAQYMAYLSTQLGTLLDEFLLLDIANDKSVLDTKDPRLPFQLSGTADILLVDKSMFTDMVPLSGLCLVIELKKKVEKKHLNQAIGQLVCASIKAPLDCYPMSLLTDLNGRWFFSFLSDKNVLTHVEFRYPKNAIDFIKATIVDQSEDDVLPLPYLAVPFKKLRVDDFLPRPVDGHAAEMMENFELMADELEPEFLIAKRAEYAQHLFFSQARVFQDITKPIVATEDLAAGQTIFQEIAIVSSGFGHSFDDCGCHGDDEPVEAHVEPETLDEDDLETVSPAVVQEFDALMSYCEGHPVLSMVDIRKNLFKLLRLYELDATSLTLLLTLEINKEEASEYLEAATGLRREHPSIIPPGLSDDDVAHLIGLLNNKYCHALEEIQGSGVFIYMSLLAHSCLPNCNLTVTGNTMWLGTARDGNLQHYKEMGPTHFINRYFKATDLAEKRIHVMVVVPDGQFGRATCKLSNEEHGEIVKIVHKVMRDSAEKVSVHSLSNMDSLMKQRILNKMVLKVAVLEMEEPRDTSIPGYPWIEDYFENQEGPRAQYMTYLETHLMTLLDTFSLQDIASEKSALDTKDPRLPLLLKGIADVLLVDKSMFTDLVPLSGLCLVMNVKKKIERKYVNQAIGQLVCASIKVPLDCYPMSLLTGLNGVWFFTYFSDKNELTHVEFRYPKNAIDFIKATIVDQSERAVLPLPYLAVPFKKLRVDDFLPRPVDGHAAAMMENFELMADELEPEFLMARRMEYAMHLVQSIPMFACMDMPTMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W6G5</accession>
    <name>A0A6G0W6G5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">2-oxoglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="5">1.2.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">2-oxoglutarate dehydrogenase complex component E1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ae201684_018277</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 2-oxoglutarate + H(+) = N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:12188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:20092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83120"/>
            <dbReference type="EC" id="1.2.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alpha-ketoglutarate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.2" evidence="5"/>
    <dbReference type="EMBL" id="VJMJ01000327">
        <property type="protein sequence ID" value="KAF0722678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W6G5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017014"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02016">
        <property type="entry name" value="TPP_E1_OGDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12470:FF:000003">
        <property type="entry name" value="2-oxoglutarate dehydrogenase E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000002">
        <property type="entry name" value="2-oxoglutarate dehydrogenase, E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11610">
        <property type="entry name" value="Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1150">
        <property type="entry name" value="TPP helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032106">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042179">
        <property type="entry name" value="KGD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031717">
        <property type="entry name" value="ODO-1/KGD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00239">
        <property type="entry name" value="2oxo_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006914">
        <property type="entry name" value="PRK09404.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008907">
        <property type="entry name" value="PRK12270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152:SF4">
        <property type="entry name" value="2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="2-OXOGLUTARATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16078">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16870">
        <property type="entry name" value="OxoGdeHyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000157">
        <property type="entry name" value="Oxoglu_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="16">
        <location>
            <begin position="639"/>
            <end position="864"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00040267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF0722678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1023" mass="115286" checksum="B6A0E7590D521DBA" modified="2020-08-12" version="1">MTQWGKLASASRLLRRTFIQANARTFSSAPHPSETFLSGTNNVYVEEMYKTWTKDPKSVHKSWDVYFRQLDQGAVPGEAFIPPPTLQPGVSPIARAANAIQSSTDVNHALGLSYLIRAYQSRGHEVAKLDPLELDVRPALPELDISMYGFTEADLEKTIAIPKNFASGVTGFLEELSEGKNPTLGYIVQRLKETYCNSIGVQYMHISDREKCNWIRTNLEHLVRVDETKEKKMHILERLAFSVVFERFLGNKYNTTKRFGLDGGESLIPGLKYMIDRATELGMEHVVIGMPHRGRLNVLSNVIRKPIHQIFKEFQGTHVDMDKYSDENPDWSNSGDVKYHLGTSFDRTYPDGRKVHLSLVANPSHLEAVDPVVVGKCRAKQFYLGNDEAADNKVLPLLLHGDAAFSGQGVVYETMHLSELENYDTGGTIHVVVNNQIGFTTDPKSARSSQYCSDVGKAMNIPIFHVNGDDALAVVKVFELAAEWRQKWHSDVIVNLTCYRKFGHNEIDNPFFTQPLMYKKIGTMPSVLDRYVDQLVASNVASKEECEAIVQKVWDFYSSTFEESKTWEAAKKSDWLANKWESFLSPNQQSRIRKTGMDFDKLKHIGQRLTTVPDNFQLNPQLKRILAAKRQSIETGEGLDWGTAEALAWGGLLLEGNHVRISGQDVERGTFSHRHAVLHDQDTNQEYVPLNTLAKTVNPASAIDVPGEHTQAPFVASNSSLSEFGVLGFELGYSLENPNALVMWEAQFGDFANGAQITIDQFLSAGEDKWMRQSGLVMLLPHGYEGQGAEHSSCRIERFLQQTDDDPNIVPPMDESNRMQIQQTNWQVVYCSTPAQYFHVLRRQIHRDFRKPLISVQPKSLLRLKQASSTLAELGPDTRFHRLLPDPATNLVADDQVKRVVFCTGKLYYELAAEREQHGINDIALVRIEQIAPFPFDKVAEQAAKYKNAEIKWAQEEPENMGFWTYVSPRIETAVKTILSDSRRPTYVGRPTSAAPATGYGAVHVLEQNRIVKKALDLPLKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W7F9</accession>
    <name>A0A6G0W7F9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_018734</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000350">
        <property type="protein sequence ID" value="KAF0722037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W7F9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019712"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF5">
        <property type="entry name" value="MAJOR FACILITATOR-TYPE TRANSPORTER HXNZ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="35"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0722037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="496" mass="54210" checksum="59B708945D4A51CA" modified="2020-08-12" version="1">MTLATASGIALVSQRLDDLQPKGGCGGISAYYLKLLHAAGIGWAMDSMDTFLFTYCMPKIKADFKANYNRTITASESGLLGSSVFAGAFVGAFMFGYLADAFGRRTIFLWTMIVFLVGMILVAVSDSFGMLLTFRFVTGVGLGGELPVASTLVQELSPKAIRGRMIVILDGFWPLGCMAAVLFANELTKSLTWRQVFFVSIAPVLYAIALRCYIPESPKWLASVGQMGKANSVVQSIEIAHGVYSYTAKPDVHENDPTANVFSYGHLHLGQRIALLFRGEYFKRTLVLWTVWFGIAFAYYAIYVWLPQIVAGGSRDAFNINGSTSSLLVILFFQIPGYFSAACVVERIGRKLTLVLFLLCAFASALAFGYVAPTQANLMVSGSCMSFFMLGAYGALYAYTPENYPTNIRAMGAAYPSGFSRIAAIAGTYVLPILHEAGWSQQEIMWLNGAILMFCSIILFVFGYETRGKDIDDVLGMDDAAMLEDDGELFSPDEFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W7M0</accession>
    <name>A0A6G0W7M0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_018150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000323">
        <property type="protein sequence ID" value="KAF0722798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W7M0"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0722798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="191" mass="19826" checksum="3EC9D1C36534597D" modified="2020-08-12" version="1">MDLKNRVPCWPLLASLAVLEAAVVVAVAVEAAALLVAVIAVNLAAAALLVAVIAVNLAAAALLVAVIAVNLAAVVVIAVVIAVNLAAVVADAVGFRSAVLVVQSFQKVACLHTVLPVHLVALLALQLVLFSKTMVRMLRMLRMKATTSVVDGATGASNVNVKVAFLQLLLWMRDWLNLDAVTLSVLLRCSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W7T1</accession>
    <name>A0A6G0W7T1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_017835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000313">
        <property type="protein sequence ID" value="KAF0723218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W7T1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009489"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="58"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="15"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0723218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="291" mass="33323" checksum="61386C26D0C6DE0D" modified="2020-08-12" version="1">MGLVILQRWWRRYLMARYLRKVRELEAQQAVLREKMEKLEARMRAIDALHSHKLCLDPARSTSDSRHSMASTKLQQEQQPETATSKNRLTKAQSAPPAMQIQPVKIQSPTMRSEQHPPTSPPRYQEAIAVVEKSLVAAIRLANTTFTSKSNAPISVNQTFQQTMQRHLTEMHTNLVAAMQAYDSPDWTTIDNFDEPLPYTLGSLPWKRLMDDWSQGDSARVGELTRWLALALNPDFKETLRPIELECMQPVVLEGFLRLIVPALMQHKDVVVQTKPIQATLLRLQVKPSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WA52</accession>
    <name>A0A6G0WA52_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Obg-like ATPase homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_017043</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000276">
        <property type="protein sequence ID" value="KAF0724230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WA52"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001307"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.300:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="entry name" value="TGS-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00092">
        <property type="entry name" value="redox-regulated ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF7">
        <property type="entry name" value="OBG-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006641">
        <property type="entry name" value="CHP00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="4">
        <location>
            <begin position="22"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="5">
        <location>
            <begin position="301"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00068719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0724230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="396" mass="44456" checksum="17CEACEC18F7309B" modified="2020-08-12" version="1">MPPKKQPEESAAARFGRVKNNLKMGLVGLPNVGKSSLFNLLTAQSVAAENFPFCTIDPNEARCAVPDERYEWLCKVWQPPSEYPAYLHCTDIAGLIRGASEGAGLGNAFLSHIQAVDGIFHVIRAFESDEVVHVDDSVDPVRDLETIQGELCKKDLAYVLAQRKAREVDVRKNPTMKLPPLFFTVMDTVQELLEANKSIASKVDWTAPEVEKINELIPAAITTKPIIYLVNLTKRDFIRKGNKWLVPIKNWVDTHGGGVMIPFSVEYEQEVWEAKKTNPNFDPEVPSVLPRIIKVGYKQLNLMYYFTAGEKEVRCWTVRKGALAPQAAGVIHSDFERGFIKAEVVAFDDFKELSEGDKRGMAKVKAAGKYRQEGKTYVVQDGDIIHFQFNVTNKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WAC7</accession>
    <name>A0A6G0WAC7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_017828</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000313">
        <property type="protein sequence ID" value="KAF0723210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009496"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050145">
        <property type="entry name" value="Centrin_CML-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23050">
        <property type="entry name" value="CALCIUM BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="566"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="602"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="797"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="833"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="923"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="126"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0723210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1440" mass="162944" checksum="F940E28C0BC88647" modified="2020-08-12" version="1">MATLDKIEWPEPQPVDLLREFPWVVGDARVTAPSTAQAERNVKITALHETSPYAEVFPQAHRVRPTLTPAQIAERRMERLVDKMDTAIASTSQPAVVVGHELRIQHGETEVDFAAWQSEAAACSSIPTATDKATTSSTSPETVESIPERIKSRQSVPSTSPTASRIKSLREIRQEVHRATNDDRDGLDLPRREFPQDPWITEQLDPVELTANLVLDVDAPDDKAADASQRSMAKYSVEMQERILSTMYATTGLDMWTDPVTSQLAAPLNSDAIFGAGTPGDAPPFDTGAIRLPDATALEATWIQQEAKQAFDNAAAHEQAGRPAQAIDALGDGIHAMLGATPAPWGFHYDLSAHKKASTIQRLYHRRYRLRSTAAVQVARVWRGFRTRRRLVKARRRADQSAARLQRWWHRCNRHRETMRLRLQTAMRAKLARLHVHALRQRRLLMRNLQLLVKAWRVQHNSLQALRRKHGYAHFCQLTKERWLRGVIARYRVRKLKRALQDEEAARYAAECAFVDLHLEPKLRDFQRLLKSTRGGAMRLSRLALRLKAEAVARDEARRHWSVADRRRAQIHDVFDTYDVDKSGTIDSNELRHLFDELGIAIDAGGLAEALKAMDADGSGSIEFDEFYAWLHAPPPPSSTSRHLREGSTLVFLKMKLNVKQFVNRFTDDSFAQHAARLLVFEESQKTQDALRKSFRVTRPPRFACRFCGTPFALYKAFWRHETAECGKNLCRRGASPEEDEALRIAHEQRAVQAALEDVTDAVHAYVATRPGRRTLQREIYRVQRLHKQTASATYVSERMKLRDLFLTYDLDDSNTLDEAEFSQISRDLGQPMSAAALSKAFRALDVDGSGKLSFDEFALWAMEQTVKVRKSWTKRLWALLVRRQQRRRQRRAEALRYIIAREKIFAEARARRAFREMFPPPFACPGCHAAFCREEAAATHAKFADAIHARQKDKLATLYARIGMTESSTSVLEAAARAVQDLKQMLAVQRYLQTRRGRYALETEVAVLKALREKAKVDPKLYVQGIVRAFAAEKTVLLRDVRHICRLLKRSTASATTTSAIRTLDPSGSGLVVESTLLAWLQDAAKARPVPRWRAQSPFWLHAKAKCIVTAKYKRYLDAGGIEITDDDDAATALSKDGRGSAAAVESDMDWLFQEYCQTSAGRDALRGEIHRLDNLQAKTTGQARASFIFEQLVNATGKTDGGERRLDVEDVAFALRQVGFPFDSRLWLELDPTATGSIALDSFQEWYAAVRKQLFETRIRRRNTRRLARALLAVRFQQQANAAARTNAAADGAHLLVTSKSEEFGKSSLGLPEVKMEVRRIQCLYDRMTLRSAAHLVAMAFDAFGMHGVVDNVDIGAVLYFANCPCDAASIDAIRRDSTAQIVHEDAVLTWLQQQTHGLHRFHRAATSCWRRFHRTDRIERLAKAIVGARQRRRLYQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WAM0</accession>
    <name>A0A6G0WAM0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RMT2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_016967</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000273">
        <property type="protein sequence ID" value="KAF0724303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WAM0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021499"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030731">
        <property type="term" value="F:guanidinoacetate N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006601">
        <property type="term" value="P:creatine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051038">
        <property type="entry name" value="RMT2/GAMT_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32379">
        <property type="entry name" value="GUANIDINOACETATE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32379:SF1">
        <property type="entry name" value="GUANIDINOACETATE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0724303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="32920" checksum="076732495C8880FE" modified="2020-08-12" version="1">MATGVNENEYALDGESKEILLSSQGQQVMMAWEKDYMEKCVEALAISSSSDVLEIGFGLAYSANRIQSYQPHSHTIIECDPVSLKQLRAWATTRPNVRVVAGTWQNMLASLGEFDCIFFDDYPLPQTERDESIFSISRWHEFLDLVLNWHTKLGGRVTGYLAREIDLTREGCSVKLEPFKVEAPSNCNYFPYSHALVPLVTLIEPKHSITAFALDQSMVVPSSSNEPKCVITHPKLVELRRKLHVQKYHDHELIDSTPTAAPARNNLSRQEWIRQLQVARAKKLETQAMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WAT5</accession>
    <name>A0A6G0WAT5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_017463</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000297">
        <property type="protein sequence ID" value="KAF0723688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WAT5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004674"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000027">
        <property type="entry name" value="Heat shock transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF206">
        <property type="entry name" value="HSF-TYPE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="8">
        <location>
            <begin position="2"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="113"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0723688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="235" mass="26589" checksum="E3782C59FB199D93" modified="2020-08-12" version="1">MSVAVFLQKTYDLIESTPADIAEWSNEGRAFVVKKIKEFESQMLPQYFKHSNFASFSRQLRFYGFDKSKKHDIRIVLDASDAESCQGWWEFSNPHFQRDAPEQMVHIRRKTYSEPTTAASSTSSESSEVNQLKRKMSNLQTQLTDLTKQITMLSSVVQAYCQSESMTSSAPSSPVPIKKQKVQVSSPLAVSSPVSISNLDWYDDMVNFDADAEIDSTILDTLLDFPAFPTNLVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WBT8</accession>
    <name>A0A6G0WBT8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_016653</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Folate-biopterin transporter (TC 2.A.71) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000265">
        <property type="protein sequence ID" value="KAF0724722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WBT8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005781"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039309">
        <property type="entry name" value="BT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585">
        <property type="entry name" value="FOLATE-BIOPTERIN TRANSPORTER 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585:SF5">
        <property type="entry name" value="RNA-BINDING S4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03092">
        <property type="entry name" value="BT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="468"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0724722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="515" mass="57030" checksum="74A42DBACD815102" modified="2020-08-12" version="1">MGLFMQYGAIGVIYGLIPALSYPIFTVYLNLEGYQTSAYSVLVVIGWSYKIFFGALSDCFPIFGYRRKPYMVIGWIFTMICLAIMAFSNLGEPYCNREKTKYCGTTLSQVPASELQYFNFNAPNKGTTFIVLSMLVSFGYVLADCAADAMVVEYAQREPIAIRGRVQTAIYTVRTITGMFALCISGFGLNGVNYKGSFSFSMAPNVPYGLCLIPCVLVVILTFWLVVDKKHQGEPVRVYAAKIWDLLQQRAVWQICAFRFVVSGLQAIGVTATSPVSAYWAKVEPLNDSLSQIIGNGIYAIFLFVVGKWGLHWNWRYCIAIATLSVIVIDGFVAFMTIWDVVRNQWFFTGVALADQVPTSVRFIVATYCAVEVADVGTEGATYGLISSIQNLMLPFGSVIYKYIDSYFKVSVNDIKADTNEVRWDVTYVYLISYGCKVVSLVGLLLLPPQRPQIQALKKKGQRSKVAAVIVIVGFLAVLAFATTSNIMSIYPSTKCYRIAGGNGKLDPKTGKCPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WCZ5</accession>
    <name>A0A6G0WCZ5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Leucine-rich repeat-containing N-terminal plant-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_016327</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000249">
        <property type="protein sequence ID" value="KAF0725175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WCZ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020273"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026137384" description="Leucine-rich repeat-containing N-terminal plant-type domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0725175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="38464" checksum="51273087A5697633" modified="2020-08-12" version="1">MNAAIAWLVLFTASLAQATLTLKMCPTADSGGAVPCLLDLHKGTTTNLPQADMLKYSFVNLGITVIEELPPTAQSIDLSFNNIREVSCQIPPSLVLLNLSYNALEPLWIQTPLNVSTLDVSYTLRGLSWIGNVAWGKVLPSLNRLIFRGNRLTRLRLGSDNFPMTPLSELDLGDNANLLVTVDFSVFDRINHADFILTLDAASYGQSLTACGGNASYVRPLRSVKIVHRTQTITYFDSYANKLVYVCCLGCTAPYVQRIPTPLTTPRPKDNINGMNFICTGVGFITILAILGVVDKLWLSKWRNQRRAALLNYEDTICSSDCSNNIRDLSPSSRIQTDFVQPPTSTRNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WD32</accession>
    <name>A0A6G0WD32_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Saccharopine dehydrogenase NADP binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_016769</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000267">
        <property type="protein sequence ID" value="KAF0724561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WD32"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015777"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000178">
        <property type="entry name" value="Saccharopine dehydrogenase-like oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051276">
        <property type="entry name" value="Saccharopine_DH-like_oxidrdct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286:SF5">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="3">
        <location>
            <begin position="8"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0724561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="412" mass="45372" checksum="E70139488CC7CCFC" modified="2020-08-12" version="1">MTTRAFDVVIFGATGFTGEYIAVEWAKNYGSSSKWAIAGRSKNKLEATKAKILKDVPAVRNVELIVADALDTPSLEAMCKLTKVVLNCTGPYRLYGEPVVRSCVATSTHYVDISGEPQFIETMMLRYNDEAKKNGCIIVNACGFDSIPSDMGTVFTAQQFPKEGCCSSIEAFLSLKGKKGHATTYECAVLGFAAADELKSLRKKDNAPIPYVGPKLKLQNMGYDNREKKYFVKFPGADASIVRNSQRYAAQNLNSVPIRFAVYAAFESIISLLLVILGGYVLSKLGQYQWGRDLLIKYPNIFSFGFFTHEGPSREEMEQGGFSFRFYAKGYKNAKTGTPDWEVVTRVAGPEPGYIATSAMVVLATKMIVDNHVKERGVLTTASAFATTPLIEEMRKHGIEFTVEKAGQISKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WDZ5</accession>
    <name>A0A6G0WDZ5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_015994</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000238">
        <property type="protein sequence ID" value="KAF0725552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WDZ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014505"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0725552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="120" mass="13044" checksum="67A7A266BA577617" modified="2020-08-12" version="1">MSDNEEATSVKTRALMLARMVQEAAEAVGTANVGLERAMELLEVSVQQSQELADEAKDNKALTLDEFEAWTTAAKLQKVVVSKVVLDEISAFRTLKANERLLHRALKSKEPSASKNGAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WE64</accession>
    <name>A0A6G0WE64_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_015961</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000237">
        <property type="protein sequence ID" value="KAF0725628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WE64"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009062"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026043942" description="EGF-like domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="243"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0725628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="358" mass="36492" checksum="F65F87E0737770F7" modified="2020-08-12" version="1">MMFKYLALVGVAVFAQDATTTPDSTATPVPISSETFKQRPGVCNAGGKECAAYGTGSDYQCVAVESTIPSLNNLAQCVKKVDQQGSNICVGSQAGVCPTFGSWPATYRAAQPVCAFTVVPTCTSAQTSNGNFVSVRELQSATTTKKPSGVECYLNNYLLANGSTTQIKGIYKCVDITFYRSKALGLDQTEKQLKACAGNSSTGFTAGLCNGHGTCSPKSQYSSEYECKCNRGYSNQDNCFAATENVCDGLGQCGGLGQCDSATNKCKCKDGAKGDQCALCDPASAAACSGSNQGSCGVDGKCVCKTGYGGSQCEVKSAPTPAPTTTPAPTQAGGSTPSGSASTVFASLAAVALAVVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WEC3</accession>
    <name>A0A6G0WEC3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RCC1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_015858</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000234">
        <property type="protein sequence ID" value="KAF0725705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WEC3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016900"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051625">
        <property type="entry name" value="Signaling_Regulatory_Domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872">
        <property type="entry name" value="BTK-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RCC1-like" evidence="4">
        <location>
            <begin position="190"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="228"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="287"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="347"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="406"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="460"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="514"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="568"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="636"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="731"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="574"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="587"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="778"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="795"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0725705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="852" mass="94007" checksum="0C001EC996C45675" modified="2020-08-12" version="1">MEPPPPSSPRARTHSRLLQASANIQAVHKVPDKPEGSSPTSRGKRRAICVVNQDSPSLIRVSTTHLHAVYGGTMAFYTICLDIECESTVVIHLLIQNDRTRAVQLSTSRLCFTPETYAIPQAVGVQATDVTHDEISIVHRVFSQDERFDQLTVPPVHLTVYGNEAAYVWTFGGDAILQEVHANAFIKRRPQLVPNLHEVDREGQPRDVYFSSISCGENFTIAVSSQSCMAFAYGQGTDGELGNHACFSTKSAVPIPCDVFATSPSDRPAIVSLSCGKHHVAVATRAGQMFTWGSGRFGQLGHYNYLDFNVPKLVHFEKPDGHDDHSAIVITYVACGGFHTLAITDAQHVVAFGHNKAGQLGLGHRQMRLDQGWRSCVPTVIDSLVNYSIHQVAAGVHHSACISTHGDLFTWGCGVDGRLGHNSTTTLNAPTLVVAAKLLEVVPRMVRCGGRHTALISDSDALYTWGANDFGQLGLGDTKPRFTPALVSFPPTCCQVILQVSLGQFHSAAVNAHGDVWTWGYDVNGGLGMDSDGSIHLEPRQVSALAGYGAVQVHCGWSHTTVLTKRNHPIRRSALSNNQEESVKSIRSTKIKHAKRPQSAQPMHRQRPKPQDEAELLETTTPVAPPASLNAFRKRMQRVRPQSAHPGSRRRPNPPMRKEPETTRSPHPFLRKNQPPRRPQTARPSARSPWIDTPRKTPEESTPAKPSMYREIARTFVGKIVHHVVAKLSWKAAKKKQQSPTSTLFSKPPPVFPVTTPRQYNATSMPPPVLEPEEQDETTPASSSLLLSSPPSSKFKTKAARKVRPKSARVDRPVPLALQLEMDKEKKRTWHEDTVESVLKEAQCHRRRLWIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WEG9</accession>
    <name>A0A6G0WEG9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_015978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000237">
        <property type="protein sequence ID" value="KAF0725645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WEG9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021287"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0725645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="125" mass="13999" checksum="5E18A3AE00D5F07C" modified="2020-08-12" version="1">MISLAHVKSTQQVEASDARRIAWPGGKLTSNKEEALRKFMERKNGIKGTSNAAPAPVETPTKRQSQDVRRKHATPKKDTLFKKHHSIRKQQPVDVVKKSPKQAKKPLPTTAKLAMSLDDIVKKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WG79</accession>
    <name>A0A6G0WG79_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-CH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_015601</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000226">
        <property type="protein sequence ID" value="KAF0726088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WG79"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010728"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46347">
        <property type="entry name" value="RING/FYVE/PHD ZINC FINGER SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46347:SF1">
        <property type="entry name" value="RING_FYVE_PHD ZINC FINGER SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0726088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="30768" checksum="68D5859E6F27D54C" modified="2020-08-12" version="1">MAPTPDYHSVENGGQITPAMVATQPSDVTALCFVCNKPQGTIEVLATELIAPCSCQIYIHRACLDKKRCTAIAIHSMTECQTCHVKYELEPIAFVDPNVLKKKIDRAKLWRGLVLLLVVVLSSWFLTNSGKPKEHRGQGSSINNTIYRWFDSTKIPYFVLFALLNSVGAAVVISLFHCSRSCWPQGCSSYGYYCLKESLANKSRGRKVVFDIVCFVIFLLVLFALGFLVVNFVILYFVIIGMAACAFDWQRQVRIRQLQVQQTCVRNLKPLAMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WGM3</accession>
    <name>A0A6G0WGM3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycosyl transferase family 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_015410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000219">
        <property type="protein sequence ID" value="KAF0726295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WGM3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004965"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03801">
        <property type="entry name" value="GT4_PimA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46656">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46656:SF3">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026322781" description="Glycosyl transferase family 1 domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="3">
        <location>
            <begin position="274"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0726295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="422" mass="46968" checksum="C1E82D78017D4A09" modified="2020-08-12" version="1">MEMPWRLSAMLLATALLSTAQAESGDRPVVQWFAPFLSGGGYCSEAISYAHAITSLNSPNFELQITQHGDSYNPKFAQALPALTRVLMESLWFEPTTSPPPTIAICHSEPGAWNPPRYQTSLCPPEGTTYSIGRTMFETDRLPSGWAQRMEKMDEIWVPTKFAKKIFEDAGVPPAKLVVVPEAVDIDFFNPALTTPFELPLVEASTTVFLSIFKWEERKGWKSLLRAYFAEFTKDDPVLLVLLTNAYHSSSDFDNLVARFALDALGRSLDELPRVHILPPDLPQNDLPGLYKSASAFVLPSRGEGWGRPYVEAMSMEVPVIGTYWNGPTEYMTEANSYPLNFDGLIAIEDGAFRGHLWADPSVTHLQELLRRVLTHPDEAKEKGKQARRDMVAKYAPSVVGAAVVDALSDVLSSLHERFDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WGV3</accession>
    <name>A0A6G0WGV3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_015352</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000217">
        <property type="protein sequence ID" value="KAF0726384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WGV3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020978"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0229">DNA integration</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="11">
        <location>
            <begin position="138"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="392"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="456"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="462"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="491"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0726384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="521" mass="57146" checksum="0E2A64AFFA4B277C" modified="2020-08-12" version="1">MQGQLGCEDQERHTYHPRCPYFPDSNVSLLSLVVFNQRGFDFKTAGVKQLVVTKGNKEVLSFQRNGPLYQLEGVCVPPDRVLAVADIDVWHRRMGHSAAKLHQLSQSGFAMPNLKGQTLGACSVCMESNLRRQSFNKEKVQEDLRDTVSVDLIFFGVTSRDGYTCAFNLVTHTHRLNYVVPLKHKSEALAAFKPFFQYYKTQQDTSIKHVKCDGGGEFAGQFKSFLDEHGVELHVTPRATPQLNGVAELTGGILGSMVRAMLKDAGLSKGYWSDALKCAAYLRNRLPATFLQGKTPIEAFLGRAPNMAYVRRFGQICFALTDSKRKLNDRGIKCILLGFNSLGYRVMELDSRQVVHRRHCVFVDDSTPSPTHATDFSSIDEVFEPHPETLDAHDYVCDTDSPTTVPDGVASEGKTRSASRTSRDPSAASTAPSTPIDDPLFTTQDPLTADIHESTAGVEGQDSNADSNAGSAADGHDSNADSNTDSAADGDASEPDDTYDAHDDDDYLAHDSDLPPVPPFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WHA8</accession>
    <name>A0A6G0WHA8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Acid phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_015166</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000213">
        <property type="protein sequence ID" value="KAF0726538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WHA8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020918"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF110">
        <property type="entry name" value="2-PHOSPHOXYLOSE PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026134323" description="Acid phosphatase" evidence="4">
        <location>
            <begin position="22"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0726538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="497" mass="54823" checksum="50EAF46A815D87DD" modified="2020-08-12" version="1">MRWGIACLLAVCAAELHQVLVVSRHGIRGPYGPDGLEPTEVNMQRYSKLKYPFPVKGTEWGTSEDEAELVSPKITKHGTHVIQNMGKYFGAHLYPTLANIQCSDAFAYADNNERDIVTAQQFLSGFLPSCTSLVPTTNDTRLLFEQGQDSTAICPATSESIYSGVVGDVTTANLVRIYKPEIKAINDLVGCCEPVLCDLNSTASCDLFGVPSRWSGKFYEPWQDTLSEAQFLSEWFLLQSLNNMTIPPPLTLDDIVQLGVLHKVHMDLITNQFNAENFGSTLLVHIVASMQQAIQGSPIPIPPGAGPHLLQSLTNKFLFYAGHDINLLYLRDLLRLEWETAHWLPNQPNVGSMLVFELHSYVNNSALESDYYVEAYFVTATPNQIRNAETLSSQNPPDRVLVSIPHCSHDVVLADGKVATRCNYTNFKEAARLAIRQACVSPTLAKYAKSMPSGPRETAWSFKVVVVAAVSIALLIVLWKYITLLNAPSGGNYAALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WIM0</accession>
    <name>A0A6G0WIM0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_014791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000202">
        <property type="protein sequence ID" value="KAF0727052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WIM0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003713"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031397">
        <property type="term" value="P:negative regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030178">
        <property type="term" value="P:negative regulation of Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46472">
        <property type="entry name" value="NUCLEOREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46472:SF1">
        <property type="entry name" value="NUCLEOREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13905">
        <property type="entry name" value="Thioredoxin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="14"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0727052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="353" mass="39745" checksum="A21BD45F484BDDF5" modified="2020-08-12" version="1">MVETTTEHRGFWADLFNGQAKPGQLTDANGTPISLQDLNPIVLVLMSAYWCPPCRALTPSLVQFAHDNKDEVSVVYLSRDYNQKMFEFNLSTKPYNRFSWNESILEVFKQLKAAYPSILGIPTLFAVDRDSGNVLAQHAAVSIRSRPATVIFEWKNGQDITEEEENAWWDTQRGEIEPVDILPILPLDTIVDGQGNPVSEDSLKQFIVLFFGATWAYGIDAISPQVTSFAKDNADDVSLLYFSLDDEESEAFKPIDGADVLRFKWSPDLRKVAYNADKIMTKDNPRNTLAAPRVLVYEKSTHALVGDNRYGITINPTTVLEAWKKGDAGVTREEISEYFARKHAEAQKKQEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJ44</accession>
    <name>A0A6G0WJ44_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_014674</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000199">
        <property type="protein sequence ID" value="KAF0727257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJ44"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016708"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="371"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="54"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="163"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0727257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="453" mass="51278" checksum="BB5D667D2ADA0774" modified="2020-08-12" version="1">MQMELTKLQTENNEIRSMNKGLEEARIELVTSLERMQLELRDVKTGRQTDSLSLESVENENAKLVKQVATHRTTAADLVKKIDDLQSELESKQRVIRNLEALKEIRERIDSDGCLECLRRMKLISEERQAKEAALSRVAGLQAALDREVDLSQEARALSESELEEIRTDRDEHISHLERLLAQQLKDQREVILAQWHHEKFELQDYIRKLEEENSKKRAALEDKSVQLQKAEHVRIELNEAEQAMANLETAIEIREESNLKLTDQLEKSRTDHQALESAHLDAQNKIASLQSVVDSLKFGRTDRLRKSEKLLEQAQAGYLKNPKHPSVNGLAFTDLLNRTDATTSLSTKSYGSTGYPVRQFVAEPTILYPSQTQTIPPGTMKQSPSQPHQPPPNPSRRYTDPKDPLRNNFGRFPYGDDGGDDGDPNGSNAGSDHGISRSVRGFHGARHGPSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WK96</accession>
    <name>A0A6G0WK96_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_014287</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000191">
        <property type="protein sequence ID" value="KAF0727659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WK96"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009137"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000009">
        <property type="entry name" value="Probable E3 ubiquitin-protein ligase HECTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF440">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NEDD-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026220590" description="HECT-type E3 ubiquitin transferase" evidence="10">
        <location>
            <begin position="22"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="11">
        <location>
            <begin position="271"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="9">
        <location>
            <position position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0727659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="597" mass="67478" checksum="379DF588DCEC1560" modified="2020-08-12" version="1">MPAAEMFSLVHLLSAVPHILCLYGVFCHIICKPRGPSEETIPLLDQNFLSFMPGIDRQELEELLTDEERWTCVVCDFGNLASDSTCNLCGALPAVNLDAVTLNSRQRAARRRKQWTRHIDTDGRARWIRHGDPSQLKTSWRIYTHVDPTNFQVMEEFVGGVATRPENRWPDMSTTPLQLHCRPIEDDKADASTTMLGTQLLQPIWEVLVAVSQLTFSSKYAWFLQQIAAMRVPFRQTHLEIKAARDHLLEGAKTELLELRGPLRCAIARHRFQGEAAIDAGAVQREWYTLVASAFMDPEKHLFQVTNQSDNSYFLASQSRDTESHDNLFRVVGRFIGRALLDGQVIPMHLNLVVFKAILGLPIVFEDLEDFDPVVYKSLTYILECANVDELALSFSVWTVEEDGSMTQIDLVENGRNIAVENHNRVDFVQAMVHHLVFDRVESHLAGLIQGLYDIVPPELLLVFDHKELELILCGLPVVDVVDWKLNAVTSPNLRHSDVTDWFWEAVEAMEPQDQAKLLQISTGASRVPVQGFKGLTSFDGRICYFTLNGVPYKAGAYPVVHACFNRIDLPLYPTKELLQDALRMLLLSDPTGFNTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WL87</accession>
    <name>A0A6G0WL87_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_014050</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000183">
        <property type="protein sequence ID" value="KAF0728043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WL87"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021371"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030258">
        <property type="term" value="P:lipid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049941">
        <property type="entry name" value="LPLAT_7/PORCN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906:SF4">
        <property type="entry name" value="LYSOPHOSPHOLIPID ACYLTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906">
        <property type="entry name" value="PORCUPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="439"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0728043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="466" mass="52567" checksum="5EF2A511298073BE" modified="2020-08-12" version="1">MATSLVDLLELLRPIRFEFLHAQVDKLSETIGFDADQLRYCLALFAAYPFAVLFRMMPRRVKPWFSFLVGVFVAQFVLGREWIHSFITSTITYFLVKWAPVSYAPFLVFAFNMLYLSASHLYRIYVDYLGWSLDFTGPQMLLVIKLTSFAYNVYDGSDPKLSTDAPPAHAQLAKVYATRRSLSISKLPSLIEFYGYTYCFATFLAGPAFEYQPYVDVIASNGPKGSTRSCLASALGKLLVGLGCLGVMIALGPQFPLHECLHATSYATVFHQWGSVYVALLVTRCKYYFAWKVAEGSTVLCGFGHTNEGWDGVSNVDILGFEFGQNIRDLSRAWNQGTQAWLQRYVYERWSNSLLATYFVSAFWHGFYPGYYLFFLSVPLATAVNRLARSVLRPHFQDKSVKVLYDIVGILATSLTINYLAVSFVALSWAESLYGWTRLHFGGHIGLVVAYLVLQVLPRKKVAKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WLE4</accession>
    <name>A0A6G0WLE4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_013948</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000181">
        <property type="protein sequence ID" value="KAF0728122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WLE4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006413"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="61"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0728122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="232" mass="25845" checksum="B29CEE0A125A4DFE" modified="2020-08-12" version="1">MHRPSSWWKPWTLKSTTPLKTRTRQASLPSSALPTLDLSRLEAPRPRAFSSRDATSPQRRLYCETCAKSFATRDLFDRHHAFSFLHKLAVHQEEDESTTLRRIMHIVHVESKSFWRLRRSALVVIAQNDLDETAIGLDSVAAIEIVVVSTSKLVSFLPQDTPFGQAVAKLVEVGCRDVKKVDALGIVLPGELSAHIASSLVEPDEFSSIFACFDRVNVDAHVMSLPSPAKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WLK1</accession>
    <name>A0A6G0WLK1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_013980</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000181">
        <property type="protein sequence ID" value="KAF0728154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WLK1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004220"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005629">
        <property type="entry name" value="Skn1/Kre6/Sbg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361:SF1">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03935">
        <property type="entry name" value="SKN1_KRE6_Sbg1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026340710" description="EGF-like domain-containing protein" evidence="8">
        <location>
            <begin position="16"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="682"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9 10">
        <location>
            <begin position="649"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="711"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS01186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0728154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="748" mass="83149" checksum="4555C7569CE83B59" modified="2020-08-12" version="1">MQLFWVFLLVQAVQSIDYDYENYPAQSGVGIWVDVNTPAKAMTKLSTRGEKWELVMSDEFEIDGRTFEAGKDHLWTALDIPDGVNAALEYYNVSNVYTENGKLINRVDEGPVNISYFNQWLEKPAYEYGQMHYTGGMMQSWNKFCMQGGLIEVSAKLPGAINTAPDNVHKSVTTNPNAVGVLWRNGQQIKLTPRDTIKDIDYYPTWPGIWLLGNLGRALFTASTTRMWPWSYNECDPDLAPHQIISACNPDPGYGLNPNQGRGAPEIDILEGGGAAISSSIQVAPGMPDEYRRLPTKEPDFSFCVYGKGCKTPGANIPDAPTSAFAFRGHKSWYQDMKYAANDRCPSVPADMQAYEPVAAVRANPALLTANVFDKTQMSAARDANADLGLIDGKGTKHWGINYYGSCFPIANGYIGAFLCDPDSKNQKCASPRREGVTPTKQMDSFEYQMDAISVNWDISHDAYTTFYIYQVEWVMGPNGYVRWNLEDQPIYEIPSATMTTPPQAGPGKPRNPKKIMIEEPMYLIFNIALARAWGARPPNSDMGPCRGNATKPVPGTWEYNKSNNICDSFPMYMEIDYIRVYQDKSSMFIGCDPPTHPTKQWIEGHIKWYTDNKNPMIRVDGGATCNSDNDCVARGAGHPSGRCSQRRCVCVTGYGGPRCTKYLGSKTLDTSSPNYFGPQPVYPVVLTALVILGIAVTAYLRQRRLASVAQVNTSTTKTDQAEENQGEENLQAKTQRRFYAPSNLASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WLQ2</accession>
    <name>A0A6G0WLQ2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Ae201684_013885</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">PML body</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="VJMJ01000180">
        <property type="protein sequence ID" value="KAF0728234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WLQ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003484"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16450">
        <property type="entry name" value="mRING-C3HGC3_RFWD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037381">
        <property type="entry name" value="RFWD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056527">
        <property type="entry name" value="WD40_RFWD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16047:SF7">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RFWD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16047">
        <property type="entry name" value="RFWD3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23419">
        <property type="entry name" value="WD40_RFWD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0853">WD repeat</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <keyword evidence="14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="17">
        <location>
            <begin position="35"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="116"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF0728234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1097" mass="122166" checksum="AFCBFF43474C3F0C" modified="2020-08-12" version="1">MSAATRGKRKLDETEENEIDLTAEEPEPSLHATECTICCEKCTTSGEHRLASLACGHLFGHGCIEKWVKQSKTCPVCNQNVRRNDVRLLFTDCIAVVDNSRQEEWNQKYLAEKAQRTAMEMEVAKLKLQHAALQLECEKHKHRVMELLEENSTLKAHATRPTLPQPPHPPWGYTKLASIPCVDARVCAIAPGCDLLCIGSKSSHPEHPHGLVQVSLMDLNHRVVIPLHRSAIRDIAISHDSAYIATTAMDAKLHITSPSAQKSILHFDMPGKLGWSCTWDDSNPHGIYVGHQNGHVSLFDMRRPGAAAAESLVHHFQQPVHSVRTLSMGDQPVVVAATFSGLSVWTNRVHAMHMEVKNCCAMANNQMEPTQLVVSSRSTVTTSQSNATPAQHFVVSLKFNEDKAVETESDAVLQGHTTPSAISRSAIWSLSPADQVLVASGDVQSHQLLLWDVTSSAIVRQYECGKSPVVDVQHAVQRGDWSSERAYLASLATDELVLYKAKTVAVHPVRIDDVRTQWHDGGIQALECFPHCCPHHAVDKFCGASISVKFYVPPARRHELDHIVVFLRLEPSDGSIRLRHGDVMRCDAMVDDVRSLHHPTGSWIPSQEYVLEEATGMATCECNQHNRLGWYLAPQVAASTALSLVAYVFYRDFDHDEPVLIVLDDVSSSPFNVGAPHSPPNDENRPPNREKQLAKLALPSTPPPGDFDTSIEFSLGVVAAFLDRMPRARAQLCVLETCARDTMLLPPVVSRAEAYAFKFPPIFATFDAASSSPSSLDPWIALATGVLACLFERPHNQALMTLCANDASSLLEKSRLRHLYTMWQDAMAAHVNGWLERQQHAGLGVRTHVALAQTLASSMNVRVQAENAIQNAFEWFVAQLRECFMAQQNHPLPQRIDRGFHSHVFNGRWRYVPDESSYFRASRLDNFAIEAPLRWITMAYSFHQRWDGHALHIRSELATHSTDWTELILDNETRVCRVFPNGEPTMRDWASMWMLGDYIGSVAATDSAGVATNLEVTFFSWPLPHRPPLAYVLQVRCHAPSSPHTLIQSWTVSTCAVPRQVDVWGLSASERHAIMLADASYTTVAEFDLRYDCQPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WM57</accession>
    <name>A0A6G0WM57_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_013751</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endomembrane system</location>
            <topology evidence="5">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000178">
        <property type="protein sequence ID" value="KAF0728386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WM57"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008879"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13683">
        <property type="entry name" value="ASPARTYL PROTEASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13683:SF375">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026160395" description="Peptidase A1 domain-containing protein" evidence="10">
        <location>
            <begin position="18"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="495"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="11">
        <location>
            <begin position="61"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="410"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="537"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="410"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="425"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="553"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0728386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="582" mass="62668" checksum="526B17A181D88CCB" modified="2020-08-12" version="1">MARGAAVLALCASIVSAHRLELHRVEDRVQIKRDFESGGRLRSLESGKFEAIPLNLGLGTHFTWVYAGTPPQRASVIVDTGSHLMAFPCAGCDGCGKHTDPPFDVSKSSTLVYPTCSSKPPFACGNCGAKDQCSISQSYTEGSSWQAVVVEDFVWLGDAVDHPVRHFNESYSTRFMFGCQTHETGLFVSQVADGILGVANGKTNLVRKLYEEKKIESNSFALCFTAHGGTMAIGTLSTSHHEGDLQFAAATSMQNGWYGVTVTEIRFGSKILPVDLSHANSGHHVIVDSGTTDSYLPSAFADAWASLFLSVTGKQYESSNCAGYSEEEIAKMPPLEIEMLSATSGQHVVFSVPASQIFSPDGKHCGGLFFTEASGGVIGANFMINHDFVFDPDQKRVGFVPAKCEYRGIDNEMPEHASEAKDKPSSAPEAATTAAPAQTTTEAPKTTTTSAPQEHNATATTAAPASTASSPVKAATTNESSNFGASITANVSNEFIAVVVLCAVVVLALVAYRKWWRKDRPKTQWTKVSTVQVDEEERVPLGEEPMSLRGNEDESDDDEFFDSEGYVMSPRSIKKTREAFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WMP5</accession>
    <name>A0A6G0WMP5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterogeneous nuclear ribonucleoprotein Q acidic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_013545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000175">
        <property type="protein sequence ID" value="KAF0728582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WMP5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010937"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21039">
        <property type="entry name" value="NURR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041337">
        <property type="entry name" value="hnRNP_Q_AcD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18360">
        <property type="entry name" value="hnRNP_Q_AcD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterogeneous nuclear ribonucleoprotein Q acidic" evidence="2">
        <location>
            <begin position="577"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="Heterogeneous nuclear ribonucleoprotein Q acidic" evidence="2">
        <location>
            <begin position="700"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="649"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0728582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="775" mass="86511" checksum="973F097DF6EE297F" modified="2020-08-12" version="1">MEAPTPSSEQVVPKRTLEDVMDDDDDDDDFEDDKPVKRPRVDEEDAPVDNSNEPSIETSELNESVNEERDSTHAQVDNANNQVEGSLAVAEETLNTAEAAASDEQNIPVVDGTDEQSKDNTTAPIDTLASPQTQDEVVTLYAQPAITQEAQDGTTEVTVEKTETLSTAAMDAHAFLDAQLLHHPTAPPQHVEQTAVSSVDATEPSVDALSLPSVHQCVVDILADIQTTHPSVVLDDAIVGELNNLSVSDALAVMQAFQAAISGNPSQPIPALMHELIATQRATRRPQDDISRSAEEEEEAPPTLSEAIWTRLLDFQHSAQSDFHLSQIRPATMDALASLPEYAQLAIVSRFARIPPGTRNKDAQLMQTLQDYERENPLLRGLEHVSKVVPDYKSDPGLFAFGFAPPQPASGMIEIAPRRLYNLHAELKQHQDKFLLDEFGRVKTGASRPSHQHHHRPSHGSPRSPPRQHAPAHHQQQQYQPPPYHPQHQQPQPQMHQGPRYDPRQDLRQDPRQDPRQDPRQDPRHDPRHDPRQDPRQDPRQDPRQDPRRGGGPPPMQHQSFGPPLLNEFRRSEIYRRLPPPIRDVLEALYAKGHIKELLNDSVLSRLLKLPEHLAVRAVENLINTDASHVDNVNGFFVGIITRVYERDRGPPPSVPGAPMMPPHMQPPPHNMDPRQAMHPSAPMRQWSKSPVHDQYIRALPPAVLAQLQHMAATGVMSSVDEWGEKCYEILGQLSEGLAIEVLKRFTMANLESVRNRSGFLIGVVKRCRQEYGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WMY4</accession>
    <name>A0A6G0WMY4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_013629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000175">
        <property type="protein sequence ID" value="KAF0728671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WMY4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006307"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF37">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="249"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0728671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="372" mass="41888" checksum="7ADA61B8CD717F17" modified="2020-08-12" version="1">MQAGVALELGGFMEDMKLSVDREVKLKLTFDTAEGRLVLTNLKCWVAAAPLHNGLGDVIVSRAVMARLGYSPRSLLESARRAQKFYDLGHLGGQDTCLMAAIKILEDKKKPPVAPEEVALNVDEELSCFPQVGVDWSVDDDQAAVRAKLKEKVGECQVTGCDDSYAVELGKLLVKYEDMFRLKLGRDPPVKVEPLRVTLKADAKPVRCKARRYSKEQREFMAKHVDELQAAGLCYRNPRSKWCSAPLIVKKPEATEFRITVDVRPVNAQTERILWPMPMLEVILDHLCGAQVFFTLDFFKGYWQFALHPDSQEMFSFLTDIGVYTPTRVLMGGTDSVAYCQSSVQEMFADELYRCLLIWLDDLLGYSKTEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WN73</accession>
    <name>A0A6G0WN73_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_013373</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000172">
        <property type="protein sequence ID" value="KAF0728801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WN73"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011915"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38696">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38696:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0728801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="231" mass="26404" checksum="434C6FCD5C08D444" modified="2020-08-12" version="1">MSRLPPLPTLALHRSDRIRLFNFPKEACEWITDAVNAKWPHKNVSIIPDPKYVELKLGGYPWSPSGEDTVHARRLMQQILLSLRMYGYALYCSTGIFNDDCGKDVLVFELREPCALNMFSISLNQHDTLRVIDAPPEIAQMLTNCINTYYEGGSVRVSDYTKGCLNFKLWSSPWTDGYQPFGTMIVAHLLAHLSASGWRLYAAINQLTKDERNSKDTWYFSYEPEAKLIGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WNR2</accession>
    <name>A0A6G0WNR2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_013288</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000170">
        <property type="protein sequence ID" value="KAF0728987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WNR2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004837"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="651"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="697"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="741"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="773"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0728987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="797" mass="89784" checksum="AB3CF0C23B42CBDA" modified="2020-08-12" version="1">MKSAESALPGAINNDGSVKVNKGQVQPLEDTQAFNTSNESREPLKAVSSVSDDRPKPKLAFYEPPGAHGDEPQSDYDGMTRHEKVEVALGMLYLVFTLVLSVYYLSILSPSMWNDLWWAQFNATWAQSYLIDLFNTQLNLGVNGSLDLTSKMYGLPKDYSQFYTPIAVSPIYPRLVFDSKMYNLAEIIAALRLFPSPERVITQYCWLDWHRRWEVAHTDLRQKRCYARYINNGAAYWETSLRLIDWNAYMAGAFGLPFNTTMGNALRKTEDGRQWLTTTPYAFVSVDAEVAQWEQANLTRFQFHITNGNMWGVHESFTIGNAFGKTQTISIKRMPYVARGALWTTIYMYLANPATYACVPCDPAWNPNPASCKPDFEMFLALPNTPCFQLVRSNIGALNSIDLYYVRPPTSLTLLYTTFRNLVAELVQSDDTFAAVMGAIPSLPIDPVPPSWLQPSFMYMGGDPTCTQRQPTTFVQSSFSFFVSCSTSDRQKILLNPLNALFALWVTSLSSVSKVCDVCPTQNSSCSAVMGAASQAAKLLIKAYPPTTSSYNLLILGAYNDVIALGVRTVQLAINTSDLSNRFLRQPVLGGEFAAVWDLYGWIYMYEWAETSREVLSFEGDANVLLLISNKYDSIVNQAQGLEVKKSACQYLWVISVVVSTILLFVGCILTFYCLFLRFRMVGRNLFQFNRVVGPVWLGRPLLLVRGMTAIVLLSTSPMNFQKTNGYSHLEFKPRSHFESMVVAGEATWISYVIIDCLLLLRRGSEYHWAPISTWIGWLALVIIDIQWPYVISTKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WNU3</accession>
    <name>A0A6G0WNU3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_013343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000170">
        <property type="protein sequence ID" value="KAF0729044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WNU3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013904"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0729044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="286" mass="33050" checksum="D81275FB1CB604A1" modified="2020-08-12" version="1">MKKNIDLTHDEYLKIHNAALLCEAAQQLYNVTEARVCGVDRQAYDSIEDNLEADNPFDFEDEELRRAKKKVRRMEKQTMGIEKRKKPSKTERRRMRAEAIADRKRRNAEIAEQRQKEQKLKAQRDEDNWTKDMSSPKQNSPPGSTWLKSSDVQPNPSRSERSRQRDRSPVREISSRRHRSPRATWQDVHDHHDAADPQDATRYGADRRDVIDLNRAADLQHAEDLAANHADDLHQMDDLAANQDDDLQHGHDLVVGHQEDDLRPTDDLAAGLQDVIPTKITHLAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WPC0</accession>
    <name>A0A6G0WPC0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mediator complex subunit 15 KIX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_012997</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000166">
        <property type="protein sequence ID" value="KAF0729246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WPC0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005996"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020282"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="485"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="94"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="509"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="485"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="499"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0729246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="709" mass="77752" checksum="5D6EDD5CD3B1BA85" modified="2020-08-12" version="1">MRKTMITEMYHELLRISGESDRQKVWQSAAKFELTLWTQSTEKNVYLTKLQKKIATLKKKPNSGEAAQPAVAPAPIQQTQPAAFQTQANNMAYLEMLKKQQEQQQIAAMNLARQQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAKAQAQAQAQAKAQAQAQAQAQAQAKAQAAAAAAAAEKQRKEQLLEQQRLLRQQQAAAAARSAATPTPPQNALAAQQQSQALLLQLTQQFQQQKQALLTTQHNELQRLRQTQLLQQNQLANLQSTQDMPQETRRLQLAQLQQQHLLAQNALSADHKAKQQELLRRHQQILQQQKLQIAAATTAATTAVAAPKPTPTPTPSQPVPTQVTAAQSQTAHAAQEKARALSRQNSLDIASSVKAPEPTTLSYSEKLKQLKAKYWDDLEVVNREFTRMAAQKPTGTSAQVAGQQERIKNFLQNLKRIMNLLAQDPTKVTSNNLDVLDKVEQHIERQVMPTLQRLKADKAKKEETVKTEAPKAPVAPTPTAAELQQQRALALQQAQALQLAKERAAAEAKAKKAEQDRLAALQAAAAKAEQERKAKEEAKAKELNDVLKLPPRNVVLTNAQRQALQNQSMQLKLKQQEYINQQSRAKSPASQAKLAQQALLLGQHIAAIAEQLAQSKNAKDKKDDFVSIVPTPAPTMSATDTFLQAIATYAKDKPDVLARAAPAFFELSLSVGATVSTTYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WPG5</accession>
    <name>A0A6G0WPG5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_012994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000166">
        <property type="protein sequence ID" value="KAF0729243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WPG5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005025"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0729243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="362" mass="37224" checksum="9BF99932A5C8A57B" modified="2020-08-12" version="1">MGCCFSKEDDNGFEAKEHLLPKGTREIAARAIPKVIAKSAYVAPELPKAKPASPVKKPASTKEIEATPIKAATPKATETAPLPAQVSPKNVFAAVENLIPLVKEESSKLLEAVSAPEVAEVPAAIVKEAAVVVEEIPAVVDEIPAVVDEIPAIVAETPAVVEEVAAVEEVVTAVEEVAVVAEEEPVVAEEVVATEEVVEPAPVVEEAAAPAVESPKKSNSRKQSAEEFVVVSTPASPEKAEDAEEAPAAPATEEAAAGNDSPVVLSPQKPVARKQSSGLIEVAEDAVVETPAAEEAVEAELAPAVEESAQEGALSPKVQLVKQESELGGDSGKDDDDDGSAPGSGAPKSKKKKKKGKKKGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WQ54</accession>
    <name>A0A6G0WQ54_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Ae201684_012791</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000163">
        <property type="protein sequence ID" value="KAF0729523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WQ54"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013744"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0229">DNA integration</keyword>
    <keyword evidence="15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="13" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="14" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="17">
        <location>
            <begin position="432"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="110"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="159"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="679"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="807"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="123"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="685"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="734"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="754"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF0729523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="943" mass="106870" checksum="57F8E0CF4176C119" modified="2020-08-12" version="1">MLKLLQQRYGNKSFMGESYLYQSLLELRIRPNESAVAYIDRFKTCIEDVQSAGMNIEPKFSVRVFFNSLDARFDTFVNFYSNTFQNGVAIDDGTLQKLFTALIQQEIRNKSTTHDAALNTSRHGPKHNGRPHHKQQQSKPSSVTCSYCNKRNHSEDECRIKAADERRQSESSNSTSRRASFQDTDDNALANTRQNQRSTQRSYGRSSSPVSMMAACHTLLQVHDNLDSSNESILDSGATDHYCKDISWFTTLEPFTGKVRVANGDDMNIEGRGTIELEMNTPSGIVPIRMTDVMYIPSIQFNLFSLSRVIRYGFCTKFSKHGCIITRDNKVYAQTIERANLLFLDIATRVKQSEVLASNAKTTSTSPAFSLLTNTPADLWHARLGHISVKYTEKTKKYTNGIDIEQCKHDFCPSCLAGKQSKLPFPQRSLTVTTTPFELVHSDICGPVLHPALCSQAKYFITFTDDYSRFGFVFLLLHKSDALKFFKKFMTYCTTQFNMQIRCLRSDNGGEYMSTDCTSYLDEHGIRHERTVPHTPQQNGVSERMNRTLVECARSMLHFSNAPLRFWSEAVLHAMYLRNRSYSASTPNGTPYERLYKTRPDLSTLRIFGCEAFTHVEQHDRSKFASKSLRTMYIGHEPDVKGYRLYCANPEKIIINRNVIFNESSCFFIDKPLSNVSELTEDSADATTAPESEDTTPAPQEPESSVPAPSLRRSTRVRRPPTHFGTPVEDTETPRPATTTTSVPETPVIDDPGQLPPLPDSPPPSPSSSTRHDERVPTEDAQDNPPATPTMDTSTTHHHEYIPVYDEPTTSVLPPIDQPQDEPIPNFQFPPVSPRSSDLSRRRHRSIDISDDDDDLHYAKRQRILMSFALSSAGLPTTIRQAYASDERDAWIEATEAEYESLMEHNTWTLCEIPPNRNLSVVDGYSPRNLQLMDHYHATKHDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WQA3</accession>
    <name>A0A6G0WQA3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_012841</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000163">
        <property type="protein sequence ID" value="KAF0729573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WQA3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011800"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="256"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="44"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="169"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="283"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="137"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0729573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="508" mass="56852" checksum="CA6053D9515CAD72" modified="2020-08-12" version="1">MVKEFDPELDSGGGLGLLDPAHEVGGDDELRMAARAGLILLEKNAALEVDVELLSTEIHRYEVQHRELSFEVEALRKQRKNSVMEVQAAHKEIKSLHMQLLQQRSASQSAEQTFLAQIRTLTSELHAITAKNQAVLKKQESEVSPEDHGNQSDDNEEVVVPEPVEDPRIAELQDENIDLQNKLQQTVQDLREREVEWTNSTHTKDLRIQSLEHEVLKLSRENKMLKEEQAEEREIMKSLRTMADTYKKIADARPFSHGAASEAGRSSATSVSEREEEEIGSMHEDVMQMNAALQERIKELEARLEKAPKTSAELDAHVLHLEDQLTVTRDMLKATKQQWISAVTAKKEAQACALAAHEEMARLQEALQVHMRTSDDKAGADQGSTSRLDRGRVGLGANCVLDGLSGDLDSPLIGCLLQNWTADKDKWDQLARWLQGVIHGHPSHAAVRLDRLSTEVTAGFVQLLVPLLRETYGTLVQVKRRTATHVLSDLILSIEAADSTKQPHFLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WQP9</accession>
    <name>A0A6G0WQP9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_012765</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000162">
        <property type="protein sequence ID" value="KAF0729705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WQP9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007223"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF14">
        <property type="entry name" value="CYTOCHROME B5 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="6">
        <location>
            <begin position="5"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0729705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="138" mass="15440" checksum="35B4BD03876C50D4" modified="2020-08-12" version="1">MESHVNEYTRRQVALHNNSLDCWVIVGKEGAKKIYDITTFLQDHPGGPELVLHLAGQDATIEFDDVGHDESARRLLETFCIGNLREDETDRLAAQQERQHVPPADSYNGIGVLLSIFVLIGATFYSQVNQGKLAQHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WRX5</accession>
    <name>A0A6G0WRX5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_012184</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000155">
        <property type="protein sequence ID" value="KAF0730177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WRX5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014409"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0730177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="248" mass="27705" checksum="4B19BDBCABF91BDB" modified="2020-08-12" version="1">MFATIERGLFPSKPTLTKLPPWQRKLPSHVVNMARVKPISEHRRLQLVHAQRRSREKRRRLQRVQAVRATLAVKLRDYLALFAHERNIHEPFSAVRAQVLEMSIFDRAVVCDGHTGRDAIQAMWTKMANAFPDFRLTVVSFKDGQDRGDDANTISALVNVTTDVGSHSTTRSGQGDLPLTLKQLLNSKMVVRAKISAGFDADTGYITSFQLRLGENDNSMALGGVKQEPAVDADMGVNKASIDFILNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WTJ2</accession>
    <name>A0A6G0WTJ2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar protein 14 C-terminal Fig4-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_011862</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VAC14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000151">
        <property type="protein sequence ID" value="KAF0730753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WTJ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010375"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070772">
        <property type="term" value="C:PAS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026825">
        <property type="entry name" value="Vac14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021841">
        <property type="entry name" value="VAC14_Fig4p-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16023:SF0">
        <property type="entry name" value="PROTEIN VAC14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16023">
        <property type="entry name" value="TAX1 BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12755">
        <property type="entry name" value="Vac14_Fab1_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11916">
        <property type="entry name" value="Vac14_Fig4_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="5">
        <location>
            <begin position="110"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein 14 C-terminal Fig4-binding" evidence="6">
        <location>
            <begin position="449"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF11916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0730753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="706" mass="78676" checksum="23E15683303885D6" modified="2020-08-12" version="1">MADQLITASSSSSSQDREFIVPLSQNLQQRLGDRQYEKRKGAALEVENLVKQLSESKSPQDKDAIPVIIDLLEKKFTRSVNANFRKGGLIGLAGTAIGLMHNAELYLDALIPPVLHCFDDSEARVRYYACESLYNIVKVARGAILKYFNQIFDGLCKLFADVDTDVKNGAHLLDRLVKDIVTESEVFDVDMFIPLLHKHIKMTNPYIRQLLVGWITVLDSVPDIEMLDWLPEFLDGLFNMLSDGNREIRQAADSALSEFLREIKSTPFVDLGPMVSILVSQCQSKERFTRLTAATWVHDFVVLGKERLVRFYADLLGAILNCISDAEGEIRGVGERANTELLALVKATAGDVDSLPLMAKLSTELVSPHIATRLAALAWISMLLEKEPAQLTAQLSSFLPTLLNTLNDTADQVVSLDLEVLARLSLNLKPVEFSNLLRAVIQLFATDARLLEKRGSLIIRKLCTLLEAKSIYMVVATVLATHDDLDFVSLMVHTLNLILLTANELEQLRAILRRSFDAKASKEDVEVFTTIFKTWCHNPVSTFSLCLLAQSYELSSSLIQKFSEIDASVGFLMQIDKLVQLLESPIFIQLRLQLLETHAPYHINLMKSMYGLLMLLPQETFRTLRDRLASVTSMAMAISKPQAPIPPASTSPSNKKEVGGVPVSAIRIAVSIPTLLAHFDEVQLQHTKQRQQALASKSVLHRPSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WTY9</accession>
    <name>A0A6G0WTY9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_011548</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000147">
        <property type="protein sequence ID" value="KAF0730996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WTY9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017441"/>
    <dbReference type="OrthoDB" id="59688at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0730996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="149" mass="16967" checksum="7BE815728CCB967E" modified="2020-08-12" version="1">MSLLLLQTSVLGALHDGSHTTYVIQVSEHNGRGIATVRRRYSAYVDLRKYALRHLTSCACGTPCLLQPILRDVFIEMETDTFFVLNTDRLIQHRVASMHYFLQRLHNELAKAPPKLVIRSEAKGCKVTALIKSYIGALPSLYDKYYLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WUD5</accession>
    <name>A0A6G0WUD5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_011670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000147">
        <property type="protein sequence ID" value="KAF0731127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WUD5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009611"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827:SF1">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0731127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="311" mass="33952" checksum="02391FDA63184755" modified="2020-08-12" version="1">MTKPANAALSITPGDVRMLKELLHSPVSSSDSECLTHFPQDEACVDETVTPSAGHQSVAQGMSLASASRSNLPQHHIGFIVHNPTMTSDDNAYHPTEHCDQSAPICSYPPPSHSSTMEFTNQAALPSTNCEQNSIPVVPKLVNFRQSAMDGQSYSPFTYPPSHTFNSMQIDPPQAYYDHEQSQQPNWTPSCPPSFSRSDATCPTMPQVTMLPVVLDRKVDKKPPRTCKFAQCTKSIQRNGLCHKHGGVRQCTKEGCTRKDRGEGYCVAHGGGKRCAINGCEKVVRRGIFCMHHTPEPSSYQSPPSGTLQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WVD7</accession>
    <name>A0A6G0WVD7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Proteasome assembly chaperone 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_011129</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the PSMG2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000141">
        <property type="protein sequence ID" value="KAF0731503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WVD7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001714"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="entry name" value="PAC-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019151">
        <property type="entry name" value="Proteasome_assmbl_chaperone_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016562">
        <property type="entry name" value="Proteasome_assmbl_chp_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12970">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12970:SF1">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09754">
        <property type="entry name" value="PAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00019186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0731503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="270" mass="29695" checksum="1395B56BA88D2663" modified="2020-08-12" version="1">MEFFGREQYGRGEAAARKLFEGTVVLTPGVSFANLGQLTIDLLINSLLAHKDVDMKLVGHLFTKRVLPMAGSSAFATQSPSDLCLNLEVYLLSLPTADHPEVQKIVFVQQRTSVIPGQVQTFCDEFAAWAKSCHASQVVVLSGVDSMLRHDPNMQMHRIERTSTSTDAMTNNDFLKQIPSLKCDETTDDVWSSVRGAGLAPFVMQSCKESLPGLAFVMYCAEGNNVPDAVYMASCVAQYLYLQRIAAFKLVLPPSWSQLFGRDPTAALYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WW69</accession>
    <name>A0A6G0WW69_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aldehyde dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_011028</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000140">
        <property type="protein sequence ID" value="KAF0731724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WW69"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013526"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07087">
        <property type="entry name" value="ALDH_F3-13-14_CALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000003">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000004">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570:SF16">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE TYPE III, ISOFORM Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036492">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="472"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="6"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR036492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR036492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0731724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="502" mass="55156" checksum="7EC1685B3B0029E0" modified="2020-08-12" version="1">MASCVASDVAALRKTFNSEKTRPLVVRKEIIKQLRRLIVENEQELCQALQQDLHKHPAETYAFEMTTVLKEIQEHLDYLDDWAAPHSVATSIVCLPGMSSIVAEPLGVVLLFGTWNYPIYLSLLPLVGALSAGNCALVRFAADGSVDATNALLASLFDKYLDRDIVRYAIGGLDVSKEVLAQRYDLIFCTGSERIGKIVARAAAENLTPVVLELGGKSPTIIDDTADLTVTARRVAWGAFANAGQTCVRPDHVFVSEMIGDAFVQQLKHETERLFSADPVAVDHYGRIANDAHFDKLHLILKQDAKYIVHGGDVDRATRFIAPTILNFKSDRGAFDRSAAMADEIFGPIIPVVYSSDLSSILAAILSRPKPLGLYVFSRNQKTIDRILSRTSSGAACVNDTMMQMSNHNLPFGGVGSSGMGRYHGKFSFDTFSHAKAILRKPFWLDLPQRYMPYTPLNVKIVRLLLSPIPRAAVRGVLGTVILVAVVLLSVYLSKPRGVKHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WWC2</accession>
    <name>A0A6G0WWC2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mesencephalic astrocyte-derived neurotrophic factor homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">MANF/CDNF-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_011090</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ARMET family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000140">
        <property type="protein sequence ID" value="KAF0731789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WWC2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001035"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.225.10">
        <property type="entry name" value="Saposin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045333">
        <property type="entry name" value="ARMET-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019345">
        <property type="entry name" value="ARMET_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045332">
        <property type="entry name" value="ARMET_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12990">
        <property type="entry name" value="ARMET-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12990:SF5">
        <property type="entry name" value="MESENCEPHALIC ASTROCYTE-DERIVED NEUROTROPHIC FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10208">
        <property type="entry name" value="ARMET_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20145">
        <property type="entry name" value="ARMET_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026257567" description="Mesencephalic astrocyte-derived neurotrophic factor homolog" evidence="8">
        <location>
            <begin position="22"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="ARMET N-terminal" evidence="10">
        <location>
            <begin position="26"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="ARMET C-terminal" evidence="9">
        <location>
            <begin position="126"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0731789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="167" mass="18831" checksum="DAE096D6AF032499" modified="2020-08-12" version="1">MKFVSVAIVALVALLSTSVVAKDDKECEVCIKVIDTLKAQYDELLKESKGTPKLDVAQTALEKTCSKLSKKEKERKVCYFLEPMKKDAARQITIGKDTLKICKDLTKKNPDFCTIRFPIQVEAGTDYSTLRVRELKKILQERGVSCDECIEKSDLIAKLKATEHMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WWR0</accession>
    <name>A0A6G0WWR0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Peptidase M16 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_010937</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000138">
        <property type="protein sequence ID" value="KAF0731989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WWR0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009318"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000005">
        <property type="entry name" value="nardilysin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032632">
        <property type="entry name" value="Peptidase_M16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054734">
        <property type="entry name" value="PqqF-like_C_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16187">
        <property type="entry name" value="Peptidase_M16_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22456">
        <property type="entry name" value="PqqF-like_C_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="9">
        <location>
            <begin position="84"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="10">
        <location>
            <begin position="242"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 middle/third" evidence="11">
        <location>
            <begin position="435"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="domain" description="Coenzyme PQQ synthesis protein F-like C-terminal lobe" evidence="12">
        <location>
            <begin position="831"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="36"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0731989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1019" mass="115906" checksum="47D7F88FDC067A69" modified="2020-08-12" version="1">MPFNIDSTKSPNDKKKYRLITLDNELQALLIQFTCDDADNHSDDGSDSYVEDEEEDEDMEEEDGDDDSDMGSSDSASESESTKAKSSRRAGACLTVGVGSFAEPGEIGGLAHYLEHMLFMGSEKYPDENSFEAFLSAHGGYSNGETDCEWTRYMFEVGPNHLEHALDMFAQFFIGPLMKADAMDRELSAIESEFNQATQSDQIRFQQVLTATSDPTHPFHRFNWGNTKSLREIPAGLGIDVRDSILRFYENFYSSNLMKLVVCGQDSLDDMELWTRRSFGPIKNKHREPPVYFNMASPFGNNGGSSLALYKIVPLKDTDAIFFHWYLPPLIGVHRMKPHDYVGSIIGHESEGSILYLLKKLGWATSISAGLTESHGYDYGTFGCIFTIEIKLTYDGFSRYDQVVAVVFQYLNMMRSTTLPAWFYEEAKTIADLDFQFQEDESAIEKCEDLAVLMQKMYRVPPEDLLSYETYKESFDATLVEETVLSHLNVSNLKIHLVSKAFSAEASTFIEEPWFGVRYAFESISKEKWSVWSCPAANSILHYPLRNPFIPKDLSMLDADTSKEGQNPRSVFQNENVRVWYKPDSIFRTPRAHVACYINIPSVISSSRSIVATQLFIRMVKDALNAYSYHAEVAQLYYELRVKESGIELIAGGFNDKLPELVYVIAQSLVSLEIRDDNFNMAKSDLSRYFNNSLLKLQNKSTYLRLQLIQETSFPLSFLIDELNQMSAERLGLFVREDLWKGGANVVGMVHGNLSEASAIQLVTKVSGIISEAARVCPMQAWIPRLVRQIGLSDKHIIWEDSEHQEEVNTLVEYYFQMSNHTIITLPVADLIQQIMEEPLFDVLRTKKQLGYEVSCSVRVTHGILGYSIKVVSSSAPTSTVSQAIDEFLNEFKQTLENMSSERLNEYIQAQIQIKNEPDINMTAASMRYWGEIITERFAFELNKDIAKWLQSGDCGRDLLLHYFDTWFGEKSRKLQIYILGKNSATRSQEFPPQIFLTSKTLFSFKAKLPLFDEVKSIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WXB1</accession>
    <name>A0A6G0WXB1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_010820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000137">
        <property type="protein sequence ID" value="KAF0732171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WXB1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021289"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005240">
        <property type="entry name" value="DUF389"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20992">
        <property type="entry name" value="AT15442P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20992:SF9">
        <property type="entry name" value="AT15442P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04087">
        <property type="entry name" value="DUF389"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0732171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="407" mass="43975" checksum="F062DA98844272BD" modified="2020-08-12" version="1">MKLFQVTIPNDQHRKVVTVLQDDLKLENVTSIEARTSSIVTFRVEDEEMQGVLTVLQKLGVGVQFGFCDVMSLTPGTTMSKTKRGKNGQHRLKRGGILQKSSDVGTAIPVAEIYARIEASTTLSRDSIGMLFISSSIAGIGLAGDSSTCVVASMLLSPLMGPILGCSFGYAIRDRNMFLTGLSNELTALVITLMLGMILGIVLAPYADDLKWPTAEMRSRGQAVSLIFGAIVAALSGAGVALAESNANISSVVGTAIAAALLPPTVNCGICLSYAIIGPLFLTDYEVTKKNVFFEIAVGSALLVWINIIFIYLSAVVVFKFKQVDKFQLIRKVDETQWQNLPKLGKTPRMRPTTLPFQDTNVSTIPLDTTETFSDETHGNNPVKRRIRGFSEDDNDSPLAKQSTTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WXP0</accession>
    <name>A0A6G0WXP0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Inward rectifier potassium channel C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Ae201684_010562</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000135">
        <property type="protein sequence ID" value="KAF0732271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WXP0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000329"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005242">
        <property type="term" value="F:inward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034765">
        <property type="term" value="P:regulation of monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1400">
        <property type="entry name" value="G protein-activated inward rectifier potassium channel 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041647">
        <property type="entry name" value="IRK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016449">
        <property type="entry name" value="K_chnl_inward-rec_Kir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013518">
        <property type="entry name" value="K_chnl_inward-rec_Kir_cyto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040445">
        <property type="entry name" value="Kir_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767">
        <property type="entry name" value="INWARD RECTIFIER POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767:SF102">
        <property type="entry name" value="INWARDLY RECTIFYING POTASSIUM CHANNEL 1, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01007">
        <property type="entry name" value="IRK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17655">
        <property type="entry name" value="IRK_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01320">
        <property type="entry name" value="KIRCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 11" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <keyword evidence="5 11" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="517"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="558"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="587"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel inwardly rectifying transmembrane" evidence="14">
        <location>
            <begin position="124"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Inward rectifier potassium channel C-terminal" evidence="15">
        <location>
            <begin position="186"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel inwardly rectifying transmembrane" evidence="14">
        <location>
            <begin position="493"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="Inward rectifier potassium channel C-terminal" evidence="15">
        <location>
            <begin position="617"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF0732271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="777" mass="88645" checksum="21CB23D7723FBC5F" modified="2020-08-12" version="1">MVSKKRFQVKSSAQQQGSGAKYEPSIKSAPWHSSWVYDWPGVDIHIDKGTKNKHFFARQALVDEWQHNFLPMIQSIQNPRKQYKDLIYILLNMRWVPFTLIIVVMYFAMCSLFALLLSACGDYQDFSDDFNLSFQTMATIGFGVLFPQSRCANYVIVAQAIVSMLLLSALSGMVFAKFAKPKAKMAFSSVCCVQPYGKDKMALVFRVANATRSKDVTRDVVMDATFTLHLMRIEKSLGADKYVLRQYPLKLLQPNFITFRMAIALVHVIDADSPLYGLTEEKLRQSEMIFQVSMTGVDSTLQDTVIERRLYTVEMVQWGKKFAEMLNFDERKMVVSVDFANLSQTVPAPLYIRPSKIRDPPMANPVITRVQENEFALSPTPKMSWSSQKRIIQRNHSGVSQSTAMEPLFEPLLQPSVGTQRIAKCRRTSQDIDIVPEQIAHLQKQLEGTESLIATAEENDVYEQDEERLLVNSMSSRHSIEITNTPRFASINAKNVPVSYSFMSFYYTALHMKWPRILMLIVGSSILTNLAFGCLYYANYDQLTVNESLANGSYPFEIAFYLSIHTWATIGYGIVAPNPESKINNTWVALESILSVIFVTIFTGIAWSKFARPRAHIHFSQNIALSTYNGHRCLLIRAANTRHHGDIRESTFRMAVILTNSKTGLRQMEDVPLVNAMWPSILIPVTLVHIIDENSPFHQFQNPDDFSVHRMSVVTLFTGLDSTFAENVYARKMYFWDDFVMSKHFENAVDFTPDKVTIDYSKFDSLLDDDIPFHLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WZ48</accession>
    <name>A0A6G0WZ48_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tag1-like fourth Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_010170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000128">
        <property type="protein sequence ID" value="KAF0732841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WZ48"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001339"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022185">
        <property type="entry name" value="DUF3712"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059065">
        <property type="entry name" value="Ig_Tag1-like_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046368">
        <property type="entry name" value="Tag1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35895">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35895:SF1">
        <property type="entry name" value="LIPID-BINDING SERUM GLYCOPROTEIN C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12505">
        <property type="entry name" value="DUF3712"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26150">
        <property type="entry name" value="LEA-2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Tag1-like fourth Ig-like" evidence="3">
        <location>
            <begin position="807"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0732841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1108" mass="118563" checksum="50C6762B75DA3F6E" modified="2020-08-12" version="1">MSNERPFLEEDDTLLDDATPHEPLLSSHARNNDEKAFGKKTTSRWTWKRTAFIGIGVVGIVAVVLALCIRPIAIRAIQATHMEIQRMELQDPSDTSVRLMTQLMIKSDSIFGVTMKPANLTIRYGNASVGAFGTPSMDISHGSIVHTIANASLTVTNMTAWTAFASEMIQSTNMTWTLEGMIDIQLHLFGISLTQLPLQKTMKLLGMQGLHSLIITKMDLSASTKTQVLAAINTCLYNPSSAAMKPVGVLCLDVFFPDPKTLKPALVAHLTTSANTSLPITQLDPSAPECTSYGKVGMNYLALSGEIVSTVASATSALISQYLGDTAAHVQVAACWPGASSIPLYNGALRHLHLNSTLPPNPVPLINKLSFDTMHLAPVDDSTIAVDMRVVVTAKSPLGDGSPLTLSAMNMSIDLQSDKVALGALTTSSVNVTGIVTSESNLTLDCKATLKLRAGGQPFGGFVHSLVQASQKTMDVVGGFNVVANGALGDLNLRGVPVKISSQLIGMNGLSNVSIVDFALPGQETPEGHQVIKATTNIWNPSVIAMAVGKVDLKMRVDGEALGSVLANITLEPSSTNRVDLTGYLNPQVNPTTHALSPAVNAFFSRYISNTNSSLGIDIAQVDSPIPWIQAGLKGISLTTIFPGVKVQLVSSLEMPQMHMHFDATSMHMHARMLAGVQMPPALATLPINITRLKLQSRLFMASTELCLLSIPELAVEYTPKSTAGTGVVKMESDIAMTQIQTTSMASFIVQLMFSAASVPLQIRSREHEGVSPTVESPLGRMALTNIPITTPLVLDGMDGFKRGGVNITAVDIVSGTADTLKLSMALHMSNPSQVTTVLDTLAVQVLINNSVLGTAVMDNVTLVCCNQTSNMVGLFSFKPASAAVGQTFLSQFVSGASPQQVDIQGTVDSSPNPYLQMALSKLRLQSSVPTLAGLFPETPTLVALSKMYRPSVWDLFTVATALQVRNPFSHSIRVTAANLLLYPCENQNKDASGHLVCTKYYASPLARFHPDEFEPMLIPGKTPEGCFTCCEGRDCGKHMKLCPGAIEGKCMKAKVEMTMWSLEVIRTLYATMTTGLLMHVEGNLTAMVDSFPMELAYTQDALLVQMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WZS7</accession>
    <name>A0A6G0WZS7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_009935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000126">
        <property type="protein sequence ID" value="KAF0733113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WZS7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004409"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0733113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="572" mass="63548" checksum="B1EC298A1C47E202" modified="2020-08-12" version="1">MTHDASNQQLQRVLASMDERLDLLTKEIESLPHRLLKMLQGHAGYDSIDLAKVDMSNLNQCNPIQQDDSQTETTKTSSDVPMNTIVDSAELLPAPVNSDCMVVAPMRTSADTDLAHVLNELHLCPSLHTTYMNITDDSNMPMVIPTAVTETPEDVANLLLLSNCPGPSTTQSASVLQLQDAADVVHTEQVDHVDVIAFTAQPKDIPNSPPAEPSSPTDFLLHISQHSSMLFQCTDGHHIDETTEAGPTETYIASISEKESIVKSKPSDNEQEEQDPSVRKSTENSTEASIPSKVECIVLPQESSPSDISDRLYAKKRIESSPSDNQIANDVDAHNTCDDQSLGESSSAFREDKEVMREIEREPSDCEVIPIEKADTVAILTSETKELSPSTRGKRRRIIEEPESEMEPSRHRLRQPLSIPLVPVVMYKWADGSMHRAPEGWKCPDAPCREMWCFWFRGDEVHQVGPFRFLKGSDISDVVSRHLLARFRAVMDQLIKTAIDHLLTDSYERLAHIPAAALLAVFDASFDILMGKTAQGTLTRQGFQHIRPVDLASYMCSTVYDIMAAAKTRRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X0A9</accession>
    <name>A0A6G0X0A9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucan 1,4-alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">1,4-alpha-D-glucan glucohydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Glucan 1,4-alpha-glucosidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_009794</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal (1-&gt;4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000124">
        <property type="protein sequence ID" value="KAF0733230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X0A9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008490"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004339">
        <property type="term" value="F:glucan 1,4-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2440">
        <property type="entry name" value="Carbohydrate binding type-21 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005036">
        <property type="entry name" value="CBM21_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038175">
        <property type="entry name" value="CBM21_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000165">
        <property type="entry name" value="Glucoamylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046966">
        <property type="entry name" value="Glucoamylase_active_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616:SF9">
        <property type="entry name" value="GLUCOAMYLASE, INTRACELLULAR SPORULATION-SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03370">
        <property type="entry name" value="CBM_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00736">
        <property type="entry name" value="GLHYDRLASE15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51159">
        <property type="entry name" value="CBM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00820">
        <property type="entry name" value="GLUCOAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026239380" description="glucan 1,4-alpha-glucosidase" evidence="10">
        <location>
            <begin position="22"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="CBM21" evidence="11">
        <location>
            <begin position="17"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0733230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="580" mass="62006" checksum="9591021899F31D81" modified="2020-08-12" version="1">MVFAAVKKVFAVLAFIAICHAANEVKVNSYTFDGTKLTGTVTLKNLAYTKTVTVIYANTAQTWGNTCSAGYTSGPDSSNNEIWSFNCPISSAGITQFYVEYNVNGATYYDNNGGYGSNYQVTTPTSAPGTPGFQADITTFLSSGLPSFKTFLLNNISPKNVSGALAGSIIAASPGGANNYVFHWLRDSGLVMDVVNEFYKAGDTALEQTFWDHAAFNKKLQGLTTQTGLGEPKYNVDGTAFNNPWCRPQNDGPAVRASSFIRFSKAYLAKGGLLSKVVDLYNGTATGVIKNDIAYVISKYSDSNGCDLWEEQRGLHFFTVAVQRRAVYEARDFANFLGDAASAATYSAAATNLDAKLATFWNANAQSVQTTINARLLDAAIPLGAIHGNNGDGVFAPEDDRILSSIAQLESGFVSEYTLNQNVKTDASGLPLSLAIGRYYGDTYDGSSNSQGNPWYLCTLSVAESVFRAATAYVKAGSITAKALNQKLFNAGAPVGLGLNVATGTYAKGTTQFTSIIEGLKVYGDKHIRRVKFHGAAGNHFNEQFNRNTGVAQGVNDLTWPYAALISTNNARAELKALSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X274</accession>
    <name>A0A6G0X274_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Beta-ketoacyl-[acyl-carrier-protein] synthase I</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_009173</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000118">
        <property type="protein sequence ID" value="KAF0734000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X274"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019811"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00828">
        <property type="entry name" value="elong_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040899">
        <property type="entry name" value="Fas_alpha_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047224">
        <property type="entry name" value="FAS_alpha_su_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041550">
        <property type="entry name" value="FASI_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982:SF21">
        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982">
        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18325">
        <property type="entry name" value="Fas_alpha_ACP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18314">
        <property type="entry name" value="FAS_I_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Fatty acid synthase subunit alpha acyl carrier" evidence="6">
        <location>
            <begin position="41"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid synthase type I helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-ketoacyl synthase-like N-terminal" evidence="4">
        <location>
            <begin position="689"/>
            <end position="877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0734000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="968" mass="105914" checksum="B772F48F49B8D25A" modified="2020-08-12" version="1">MPMLMQSFAAAAPVENVPDVDIIAAYGLKAFLAPKFATYNKPGKYLTSTIVKLLSAKLPGGFSASQLRVCMAQERYLGPKRIKIALIHSLANAPDARFATEADAKTWVNLAMDEYGSVFSVPIPYALKAGGAVIAGVPMMGGGVSSAALDALKTQMHTMMREQVNAYQAFRKFDSLATLKKTNADQVARREKQIDLWVSERGEYDEKGIQPKFDAKKIRIYGSYWKGVKQDALYYRTLANVEGVKIGARASKLILFPFNQASSKDRGALVAHIYEQLNLDLVIPFDAISGPTLSDIDSKSELAHCIMLTNTYRMLGKIIDYKGARNTDTRPCFATLSLSPNHGTMGGGLYAEAKLGLEALMNKWHSEGCEHYLTGAVIGWTRGTGLMAGNNNVSVGIEKLGVRTFRHVEMAFDLTSILHPRMVAAAAKSPLWVDSGGGMAQLHDLKIQTDTIRTAITDESKIRRASVDDRLKGSVTDVVDAAKPVWNRDNMYKDYAQLPDLPAASELATLGKNYKGMINLEKTVVVVGFGQVGPWGNSRWEVESYGKLSLESCVEFAWILGYIKYHIGPLKSGQHYIGCVDAKTQDPVADTQVKSLYAENILKHSGIRVVEPELFEGYDPKKKIVLQQVDKNMRPIEVASREGLESQKKLGEDNCDVFDGSWMLRLRQGAILSKNLHFNRWVAGRIPTGWDAKRCGIPADIAEAVDPITLFTLVSTAEALISAGITVPYEFYQYVHVFEVGNSSSSGIGMRSLRRVILDRANGINVPSNTLQETFINTMVAWVSMLLLSSSGPIKTPVGACATSAASVDIGVETILSGKARVIVVGCYDDFFDGVSYEFAQMKATSDSEKEESMGRYPREMCRPCTDSCGGFMESQGPGTRNTMDAALAIEMGIPVYGILGCSNTATDKNGRLVPAPGKGVATTAHEHDVGNGKMRNALWKPVFRRAQFEDEVKGIELWRERQLLAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X2Q2</accession>
    <name>A0A6G0X2Q2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_009234</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000118">
        <property type="protein sequence ID" value="KAF0734064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X2Q2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011230"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0734064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="435" mass="48480" checksum="28755FFEFD97A7B5" modified="2020-08-12" version="1">MCGQCNMVSYCNRACQTQHWKQHKTQCHVVPHAKSVEDVRHDFETQGDPSTEMVALANVLLKVLLVANPTSGPATIAKEYIAHTPPLVNEWMQRLAARPAFYSKVPLQACTNLVKAVHELTQAMAMTEMEMVHPQGDLLNHEWIVKRVNSVSIAALMWFSHAPLGDVRQVEEHIYSPTLHHSYTNALPPLVSFDRVHVAVGYVDLSMLFTATNLTAPLRWIGYEASVYSVAKTLVLRRMLLDEAAVDCILQVWYSSAWSERTLRQFRAAVVSVLSHDWPPSVAQLLAWWHQHTPTLAQARREWLGKTDHASLDPLANAASPQSRAHLFDYLFTGQLLEATVGSVTMCCLPPGFESSCGRDESVFQTIPWSDLVDAIEDGDLVAAATTTLRHKLRGLQENMMRGKIVVDIRPPCLVSQDSARDVAPGTPRRSHGAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X2Z5</accession>
    <name>A0A6G0X2Z5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_009098</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000117">
        <property type="protein sequence ID" value="KAF0734237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X2Z5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020584"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052050">
        <property type="entry name" value="SecEffector_AnkRepeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586:SF3">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0734237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="228" mass="26130" checksum="AB9883102DE39E17" modified="2020-08-12" version="1">MLQRALKRSRSENHEIPARLEIFTTPELMEIVTAFQNGIPHDMTVFLVFDPKRLRSRKLQDGHGFNMQRVHEVIAKWLDQFGYSRLPKLFSALAYMRYLVAVDAICYNQMALAKYLHDTFDLSTIQGNFLDLAVHLNNLPMLEFLHACGCQGCTTDAMDTAAKNGHLDMVRFLHTHRSEGCTSHGLALATIHGHNDVVLYLRQHGLADYEKDWLKRALVRKHCKPIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X3R4</accession>
    <name>A0A6G0X3R4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_008775</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000111">
        <property type="protein sequence ID" value="KAF0734532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X3R4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010663"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16449">
        <property type="entry name" value="RING-HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000572">
        <property type="entry name" value="CDK-activating kinase assembly factor MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015877">
        <property type="entry name" value="MAT1_centre"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12683">
        <property type="entry name" value="CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12683:SF13">
        <property type="entry name" value="CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06391">
        <property type="entry name" value="MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="13"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="249"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="269"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0734532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="304" mass="34368" checksum="E86D6024CD8DBEFD" modified="2020-08-12" version="1">MGVMDDDDLLAKCCVCGTSLDDDANVLNTTMKMKISKCGHRYCDRCVKLEFQHHREITCAKPGCGKLVKKSQLQDKTKEEQDFNKDVTIRKKVLKTYNKTGEDFNTLDEYNAYLEEVEDLIFDLLSEDDAVKDAANAKWKQYKQENALLISANDAKKAEEERRVLHVIDEQRRVADERRRLQLQEDNKFQADLERQKAQLMEVALGERDEKDVEQVQNPTTAIPIDQPLSAEMEAAMMGFQPGVFGGGPQPVPVHGGKKGQGAADSRQLRTTQQRAGGYDPQSSINRNVEEAWSGLFLRVGITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X3W2</accession>
    <name>A0A6G0X3W2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_008793</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000111">
        <property type="protein sequence ID" value="KAF0734551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X3W2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014430"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF467">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0734551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="37394" checksum="EBF842A5BC0184A1" modified="2020-08-12" version="1">MKDLGNLTFRLGIEVERLQDGSIFLHQRKYILDLLATHGFTDCNPISTPQASSATRSSTASSPLPYRQVVGDLQYLTTTTHPDIAYTVTFLSRHLNEPAEEHQQIAKRVLRYLKGTQDYGLLYSKSDKEDFTTDLYVDADYANDTSTRRSTSGFVLFLNGCLISWKSKLQNIVALSTCEAEYISMSYGLLEALWLKSLLEELQLDIKLPINVYEDNQSTIKMAENSTLQQRTKHIDVRHHFIRDLVKQRIIKINYCRTNSMLADILTKAPPKPMFEEHMPKLVTSIPPSNNEETSRLEGSVEERVASVRQIFDYPNQMFGAHTRHLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X569</accession>
    <name>A0A6G0X569_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_008468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000102">
        <property type="protein sequence ID" value="KAF0734995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X569"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000079"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049500">
        <property type="entry name" value="Peptidase_M50B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33979">
        <property type="entry name" value="OS02G0221600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33979:SF2">
        <property type="entry name" value="PEPTIDASE M50B-LIKE-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13398">
        <property type="entry name" value="Peptidase_M50B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0734995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="293" mass="31986" checksum="ED2E4C27D2AEDE4E" modified="2020-08-12" version="1">MANVGDGNSWWTLGCCNDEQMQSIFLIVGYVVLIFKLWRFPLMHPFKILTVFLHELGHALAAWMTCGKVTGMEVHPNEGGVTKYIGGIAFIIVPAGYLGSAVWGMALVIASPDKLSAEIAAGILIFFLLIFIFYAKNSYMRWLNGGFIILLGGLLALDIATKVNSLRYVILLMGVMSCLFSIYDIWDDLISRRVNNSDATVFANMTHTSSRCWGVIWGLFALATLDGAVYFTLLVSQHVSPAPPVDSIKDLSSSSTIALVFSASVLVLGIIHTVLTRNCMVRAGSQFGYAQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X6N7</accession>
    <name>A0A6G0X6N7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_007929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000094">
        <property type="protein sequence ID" value="KAF0735610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X6N7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002574"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.239.10">
        <property type="entry name" value="Elicitin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036470">
        <property type="entry name" value="Elicitin_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026259387" description="Secreted protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0735610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="16137" checksum="1D78E065DDCB10F3" modified="2020-08-12" version="1">MKTTAILAIALASTVQGATCGLEVAQIFTDATTSPEALTCAKDSGISLAPNTKYTDADLAKVLATPSCTTYWDGVDKKVNAVNPPCDFPNPKGDGTTLNSATFKWTFKDLFSLGAANSINSSATDGAATTTTAAPTTTPKSSSVVAVASTLIVAGVALLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X6U8</accession>
    <name>A0A6G0X6U8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_007731</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000093">
        <property type="protein sequence ID" value="KAF0735722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X6U8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013560"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050505">
        <property type="entry name" value="WDR55/POC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019:SF8">
        <property type="entry name" value="POC1 CENTRIOLAR PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="9"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="51"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="93"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="135"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="177"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="219"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="261"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="311"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="384"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="466"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="389"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="402"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0735722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="497" mass="55355" checksum="5F8121D35BA4BA85" modified="2020-08-12" version="1">MDPSLERTFRGHKSGVEALAYSPNMRQLASGSVDCTVMIWNFKPQTRAFRFLGHKGPVYDVQFAPSGDLLASASQDRSVRLWIPTVKGESHVMKGHAGGVRSVDFSYDSSELLTASDDKSIKMWSLPTRRFVCSWNGHSNWVRSARFSPDARVLVSGSDDKTVKVWDKATRHCLATFFEHSGIINAVRFHPDGNTVGACSFDHTINLWDIRSHKLIQHYPAHEGSVTSLDFHPSGNYLVSTSVDGTVKLWDIREGHLLYTMHGHNGAVNAACFSSDMKWTASGGVDSLVMIWNTDLDKCLHPNDSGFPMALPKSKVLKHSPPSHPSSSSFHAPSMPPQTPPVVTFASSPKTVDAVVRPFRSDQFNPAAIVPAEPTMERHIEDEHVQRMPQPPSRQSPPRSPTLSAAPSMSVSPLPDHLTATFDHIVGQLEIITRTLSILEERLCHAEDRITDVARVQSQMLRQQNVQVPTMQMPPPQPQRRPTQPNYHQKQEEEHPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X740</accession>
    <name>A0A6G0X740_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cyclin-dependent kinase 2 homolog</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cell division control protein 2 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">cdc2-related kinase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ae201684_007822</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">May form a complex composed of at least the catalytic subunit CRK2 and a cyclin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="VJMJ01000093">
        <property type="protein sequence ID" value="KAF0735817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X740"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002076"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07829">
        <property type="entry name" value="STKc_CDK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF171">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="24"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF0735817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="340" mass="38406" checksum="DC33875419CFD6D3" modified="2020-08-12" version="1">MMEKAGGDGSVFEIFMMATFEDKYELLERLGHGNFGEVHCIRDISTGKVLALKRVRTGNDSSKMETIPAAAFNEIQAMQHLNHPNIVHLVDVVPEGASIGLVMEYMDTDLAQLISTATRRFDAQEIKSLLFMLLRGVEHCHKNSILHRDLKPSNLLVNREGVLKLSDFGLATVYTGPNREYAHQVATRWYRAPELLFGSRSYDEKVDMWAVGVVFAEMLQHAPIFPGLNDIDQIFRVMQVLGSPKWPGMEALPDFHKISFPTFDPIPFEKLFPQAESTALDLLSRLLSYDPSARPSATQALQHEYFWSQPLPQPYIDADIPKRRAEAYNPSTFDVAASFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X7E3</accession>
    <name>A0A6G0X7E3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_007770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000093">
        <property type="protein sequence ID" value="KAF0735765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X7E3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014491"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0735765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="301" mass="32973" checksum="4466BA9C61D2804D" modified="2020-08-12" version="1">MTFSLSDIPDQTRRVAIVTGGTAGLGLQSVIVFTARSPARGQEALDKVQAALAPASFKVEFAIAENEDLTSIVRFADWFIARNLPLHVLLLNAGGGLAPYRAIHGVDSALFINHVAHHLLATRLLSVLERSAPSRVVVISSLAHSGVKTLDLDLPEKDQYDTVKAYGISKTAQLLMARGLMQQVGSAKVFVNSLHPGMVVTEVINRPIEFPHLPWFLRSIAVSLFKIVTKLFGTTPAKGVLTHMYVATSPDIENNDWRGQYFSPVAKLDKSSPLSENQDEVERLWKWTTAVIDRVLAESKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X816</accession>
    <name>A0A6G0X816_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_007193</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X816"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020560"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
        <property type="entry name" value="FYVE_like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43102:SF2">
        <property type="entry name" value="GAF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43102">
        <property type="entry name" value="SLR1143 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="287"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="347"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="358"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="398"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0736170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="483" mass="54616" checksum="9799C490CB85F7B3" modified="2020-08-12" version="1">MLMHTSTTPTATAAASVRAERAVVPPPPVLLSLAEVDVIQTAARRQCKTQVRQTQVLNGPIRWRLLADENELKICKGRLRTQPSTTVEPPFYLSVVEVAATLDEVIDVFRTDTTQHAKAYTRRFAKDVVGATTLATLTTPGLIDQPLSETHIVVSWVARKQHPASWLRHNQDMCLIEASQLVKIDGSPGWVHSAQAVDYREYEWCPRPTKAYRRVSHFLEGYVVKASSRPGHMLVSYMVLDCLRLPAWYMDMAMKRRCRKLMSLDHYLRENRLHATPFLNLPQLVPKARRRQCFLCQKSFNFWSSKGNCTKCGEVVCSRCSALWQVQVSSFPSFMRVCSTCALGSRRSDRGFPVPRRNSLDELHASGRRDEETTWRKSGGRPSTKSPFPLPSPREFDIDPADDDVNEEAARPRTSSLSRRKTTNKTTLHETCPSHLLHVRTTPESSWHPSTVRLSSAATSISLDPRKPTRETRGDDLVLGWTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X9Q1</accession>
    <name>A0A6G0X9Q1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_006985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000087">
        <property type="protein sequence ID" value="KAF0736829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X9Q1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017768"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0736829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="352" mass="39685" checksum="5EDC0961DA453A4B" modified="2020-08-12" version="1">MKKVIYYEGFFQRVSSKLPEDVNYAAKKLLRRCYEYREAIREELQSSVAYVADAGRWAIGLEDWNTKMDKRMAQISELVVLANSLLAEYALTGEIGAKGAVDDLSAYVNVITSTIVLQEEALFHDSLKGNKSISPLHSQYRSTAVPTAVSVETIPGDISEPTTIVLHPEDVELDMPAPEDEDRLNPFNIDPKTPLVKTQRTEPMAIPTKELPRSSDVSDESSRSLTSSFPSDYCHLDGDELQDMTSFSTTAPRKERLAKPRTEKKPFDNAVYDLTVSFDFQKERASNPFMAKPYTERRNSLGEHSSIDEEGTGSIHENDEFNRFPHPPTQREEEARYPDSANISYAEGVDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XA06</accession>
    <name>A0A6G0XA06_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_006952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000087">
        <property type="protein sequence ID" value="KAF0736794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XA06"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021786"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0736794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="75" mass="8543" checksum="785EB6BE15972AA9" modified="2020-08-12" version="1">MSKAEIEAEKWIFVVPYAPGKYCLPLCAVPFQRWMLFLAAFIAQFCNGCLYAWSILNPYIDNFIQDKTATGNDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XAF5</accession>
    <name>A0A6G0XAF5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_006825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000085">
        <property type="protein sequence ID" value="KAF0737014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XAF5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015987"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0737014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="365" mass="40640" checksum="0838071B4E94EC3A" modified="2020-08-12" version="1">MANRRNSARSSSPSLTQSRRRRTSTMPSPFSPSASSPLRIPEPTAPLRLTTMEKAQLLELAHFAAAELTSFVFRLHSKSHKRSPDASSSGTVLRAHTSILSDYMTLNDYHAHVHSYAFNGFHATSTLCALHGADGSIVTVKWSVAKSTWTHDRDFCYLEIQKPFVGPMGHQGYLRCLHSIPLFISSSKARHIRGMIFHSGVVAMETASRQVEETIVMQVDMRGHIPKWIASILVSKIVIRARTKPYYVSNEVSKNMDGVASWQVVSQRRASQSTSRASVNDANAQCKVCLTQIHWYQPRVKCKVCQAIACKPCTTHCEALLKPTDRACLLCNAQLAAMLAKSEQPEETFVVVDGWDEWSSHRVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XAF7</accession>
    <name>A0A6G0XAF7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pyrroline-5-carboxylate reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ae201684_006909</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-proline + NAD(+) = (S)-1-pyrroline-5-carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14105"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-proline + NADP(+) = (S)-1-pyrroline-5-carboxylate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000085">
        <property type="protein sequence ID" value="KAF0737105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XAF7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021115"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3730.10:FF:000001">
        <property type="entry name" value="Pyrroline-5-carboxylate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000190">
        <property type="entry name" value="Pyrroline-5-carboxylate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.10">
        <property type="entry name" value="ProC C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645:SF66">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 12" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="13">
        <location>
            <begin position="49"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase dimerisation" evidence="14">
        <location>
            <begin position="207"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="53"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="114"/>
            <end position="117"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000193-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF0737105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="317" mass="34385" checksum="D4711C6BA40063E5" modified="2020-08-12" version="1">MLCRVAARQIRYVRHRSHSAVLKEFAPMFTKTNQVKEGAVPNEPLNIQRLAFIGGGNMAEAIISGILAQEMLPPEKLMVSAPTQETRSKFERMMIPTADKNKKAIAGADVLVLAVKPQVLPQIYPDLLEHMSPDTLVISIAAGVTIDEFKTNLGPEVCVVRSMPNTPAMIGEGITVWAQSSNVSDTQHKLTKNILGAFGHEVFVDDEKNLDMATALSGSGPAYFFLVAEAMIDAGVHMGFSRSVAQKLVQQTMLGSALYMQSSGKHPVVLRNNITSPGGTTAAAMYRAEKSGFRAVIADSIWAAYERSKELGAQKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XB63</accession>
    <name>A0A6G0XB63_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">RING-type E3 ubiquitin transferase (cysteine targeting)</fullName>
            <ecNumber evidence="17">2.3.2.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Peroxin-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">Ae201684_006564</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-S-ubiquitinyl-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.36" evidence="17"/>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XB63"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021765"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025654">
        <property type="entry name" value="PEX2/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48178">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48178:SF1">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 18" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="19">
        <location>
            <begin position="263"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAF0737399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="324" mass="37458" checksum="96F7C79B2876BAE2" modified="2020-08-12" version="1">MWQENNQSAIECLAHLRQIVSKSSSLELFHASANLRVNKWDALVLDGEIMSLMKHPIKNMFAYFPPGLMEKFQPEIDGGMLALLFFFSVGMKKPTPGMALQNLNYAADCFTLKKTVHLFLFSVAIPYGWKRIHRMLLNWRWREDRTTEAEEKYQRFLTLLHRVSTIVAVCQLLNHIAFFRNGQYRTLAERLVGMKLQKTKPILQPRAITFEYMNRQLVWDGLVEFGSFMLPLINWDRIWRIVRRVGWFLPDDASVARARQNGCPICLAATAKTPYKTSCGHTYCYYCLQTAVSTQPDFSCIVCGDVFQSSYRLTNPQLDQSNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XCC0</accession>
    <name>A0A6G0XCC0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PSI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_006330</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000083">
        <property type="protein sequence ID" value="KAF0737663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XCC0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020426"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026351611" description="PSI domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0737663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="26191" checksum="FC73889CAFDADD0A" modified="2020-08-12" version="1">MAKGVARVLTLFGVLVARSNSQDTSVCLSLACQERGSTICNRDVDDCPPCWQFDTSSPTNVTCGLELTDGPCRDEFTYCPDYWTSAATTLTPEPTTTTKKPNTTTMTPEPTTTTSSPTTATPITTATTTSPSTVSPSPAKSSNAGYYALAGIGGALVVVAGPWFVVRARRKKQKPSENSYVVVKEVPKSPPSVAPTNAGDRGSLLQSRVESVHNDEALREDVWGNITHQDGANQPLSFSNPKFLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XDU2</accession>
    <name>A0A6G0XDU2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_006146</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0738169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XDU2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001226"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23244:SF471">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23244">
        <property type="entry name" value="KELCH REPEAT DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25024">
        <property type="entry name" value="EGF_TEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026156943" description="EGF-like domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="664"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="668"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="689"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0738169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="770" mass="85571" checksum="6EE76FB623B92DE7" modified="2020-08-12" version="1">MRTWIVFVCLASSGIAVLSLQLGAGPGPRRGHSLALHGSRAVVFGGRADDTETPHVPRTYDIMDVHGKLEFATYTDLPVKDTCTDDTCAVPIGVYFNDVWAYDINCTRYAEDSCVDKSWVQLREGEAWGGCSMHFGALICPKPPERWFHKAQVFGDTMLIYGGFGLLCTDYCDDMWQFNFDDNSWTELRELGSPLPGPGKRWKFSSSATATSMFIFGGYRLWQGFAPQNSEANQWSDTSVYPEGGYLDDLWQYHIANASWTQLPKMPSCSATEASCSMDWPPGRAGHASVIFQDGLYIHGGYQTFFPYPTTSGAGAGRGVMPGSPPGYTPFPTNPYYLSDLWLFNITTGLWEEISPRFGTMPGPRAEHSMIAADKVFVLFGGYRSNYYYDDTWQFNTTVSQWLEQSAFLEALYPVNCTDDLSARANPHSGTYRAYVPVNDSTKTTLELEKEAHYGTTTFSVIADPTRGLGLSTPTFYSQARRQAPGWDGCRDRVDDRTDLPWDLQWSKPNQRAGHTAAYHSGYHLMLLYGGYGVEREELYKTNSTTPAVTYGDWWSYSLANCIKNCSLHGICSYGHCVCDDGYYGTDCSNITCPGSVCEYDDVKQSTTCAHCCFSGFEHTGNDTYVPNIQKLPCSGNITRYSNGICDGFGQCICRPPFIGADCSIRDCAYNCSNHGFCSIEFPNSRCMCDPGYAGKYCQEKICLNNCSYPNGVCVNGSCYCSMLYEPYNKTLEYFPYMGEDCSFVMPFCAAPPSAWAAWSAVVIAFVAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XE43</accession>
    <name>A0A6G0XE43_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable pectate lyase F</fullName>
            <ecNumber evidence="5">4.2.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_005730</name>
        <name evidence="14" type="ORF">Ae201684_005731</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Pectinolytic enzyme consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins. Favors pectate, the anion, over pectin, the methyl ester.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Eliminative cleavage of (1-&gt;4)-alpha-D-galacturonan to give oligosaccharides with 4-deoxy-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.</text>
            <dbReference type="EC" id="4.2.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the polysaccharide lyase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.2" evidence="5"/>
    <dbReference type="EMBL" id="VJMJ01000074">
        <property type="protein sequence ID" value="KAF0738501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VJMJ01000074">
        <property type="protein sequence ID" value="KAF0738502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XE43"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007425"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004898">
        <property type="entry name" value="Pectate_lyase_PlyH/PlyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33407">
        <property type="entry name" value="PECTATE LYASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33407:SF9">
        <property type="entry name" value="PECTATE LYASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03211">
        <property type="entry name" value="Pectate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033880062" description="Probable pectate lyase F" evidence="12">
        <location>
            <begin position="23"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0738501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF0738502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="259" mass="27343" checksum="ABE3135AD59D043B" modified="2020-08-12" version="1">MVQIASFAILAAAASFFDLTSAVAPLPTGAWPTSLGNVKYSAPYVVKAGTVFDGQMKTYERSNVACTGQSEGGKDTAVFLVEPGATLKNVIIGKSQAEGVHCESHDCTIQNVWWDDVCEDALTIKGGSASSVTKVIGGGARSAEDKIIQHNGAGTVSIEGFYAQDFGKLYRSCGACKTQYQRKVTVTNVYAVNPKVTLVGVNKNYNDQAKFSNIKIKSSKTPKVCTYFQGGTSGEPKELGNGILSPTCQYAASDIHVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XEG1</accession>
    <name>A0A6G0XEG1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_005558</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000071">
        <property type="protein sequence ID" value="KAF0738630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XEG1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020717"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000059">
        <property type="entry name" value="N-ethylmaleimide reductase, FMN-linked"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="4">
        <location>
            <begin position="4"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0738630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="356" mass="39255" checksum="57B993B84BE0A871" modified="2020-08-12" version="1">MSVNLFTPVQIGHVQLKNRIFMAPLTRIRAGPSHLPNDLMKEHYAQRASAGLLITECTMISPNLSAFVGEPGVYSNDQLIAWKEITDAVHAKDGKIFIQLWHPGRRAHPDNNDGAPNVAPSAIALQGETPTLKGKQPHAVPRELTVGEILEIVEQFATAAKNSIDVAGFDGIEIHAANGYLIDQFLHSCANTRTDEYGGSLENRSRFLTQVLQAVTDAIGADKVGIRFSPINSHGWTVNEDPFELGEHLAKIAERFHVAYVHILRRDMFKVLQGDVEQTFRKHFHNTLISNMGYTKDEANAKIESGVIDAVAFGTLFIANPDLPERFAKDAELNQPNPATYYSCGAEGYNDYPTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XEY0</accession>
    <name>A0A6G0XEY0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_005427</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000070">
        <property type="protein sequence ID" value="KAF0738816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XEY0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016795"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008841">
        <property type="term" value="F:dihydrofolate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="entry name" value="Mur ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF0">
        <property type="entry name" value="DIHYDROFOLATE SYNTHETASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001563">
        <property type="entry name" value="Folylpolyglu_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur ligase central" evidence="8">
        <location>
            <begin position="25"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Mur ligase C-terminal" evidence="7">
        <location>
            <begin position="255"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0738816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="426" mass="46427" checksum="633ECCB2446D6D5B" modified="2020-08-12" version="1">MGLRNAEALHQAFGEPSKRFDTIHIAGTNGKGSVSWKLAKALQASGFKTGLFVSPHVACFRERIQVNSELISETQVEALLPTIFEKSAELKIPATFFELTTILALQHFAEEKVDCVVLETGLGGRLDATNIVLPVISVITSIGLDHTRILGSTLPEIAREKAGIIKPNIPVVIGPNCQQEVMEEHARLVGSPLTSLPPHPAYNDDYNFENTDVATLAATILNSSAKSKVRIDLQNESVRKALLSRPSCRFEEVHVRRNNQDVVVVLDVAHNMPAFERLLKLLEGRFPGQTFRFVCGFSADKDIGHVINLVTKTRTNHVHFVQGYHPRCASMVEIRHSLGEKSIDNVSFHPIVDAANSTSVGSGVEAAVRAAASSQEVVVVCGSVFIMSEARQALGFDEPVDSDAVRRISGAGLKTASDREQQLEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XFJ0</accession>
    <name>A0A6G0XFJ0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_005182</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat PRL1/PRL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000067">
        <property type="protein sequence ID" value="KAF0738992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XFJ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000495"/>
    <dbReference type="OrthoDB" id="10256122at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000012">
        <property type="entry name" value="Putative pleiotropic regulator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045241">
        <property type="entry name" value="Prp46/PLRG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923:SF0">
        <property type="entry name" value="PLEIOTROPIC REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923">
        <property type="entry name" value="WD40 REPEAT PROTEINPRL1/PRL2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="178"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="220"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="262"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="304"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="387"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0738992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="495" mass="54881" checksum="EE711964C80DB0E3" modified="2020-08-12" version="1">MATDLATAVDATTASEKIAWSVKRSRELFAGDLDSFEVNEDSQKTHIQVKFRARYANIPDVQPSQLKKSKLDAKAAVPEVVAESPPEEVDDVAMEETKPAQQEADLPSVMDKAVEQLAKQQEATSAASSGQQALVEYKKETKFAAQFQGTSSALVRRRQAAEVPKPTWHAPWKLKRVIAGHLGWVRSIAVDPTNQWFVTGSGDRTIKVWDLASGQLKLTLTGHINAIRGLAVSDRHPYMFSAAEDKKVLCWDLEYNKVIRSYHGHLSGVFSLKLHPTLDILITGGRDAVARVWDMRTKQQVHVLSGHQGSVWAIETQGTDPQVITGAADSTVKLWDLAAGKVMTTLTNHKKGIRSMACSRTDHTFLTGAADNLKKWQLKDGKFLRNFSGHNAIINAVSVNQDNVLVSSADNGTMRFWDYTTGYCFHQEETIVQPGSLDSEAGIYASSFDMTGLRFITAEADKTIKVWQEDPEATPETHPIDMVKWTKEFTAPKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XFZ2</accession>
    <name>A0A6G0XFZ2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">AN1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_005288</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000067">
        <property type="protein sequence ID" value="KAF0739111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XFZ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010976"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057357">
        <property type="entry name" value="Znf-C2H2_ZFAND2A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677">
        <property type="entry name" value="ARSENITE INDUCUBLE RNA ASSOCIATED PROTEIN AIP-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677:SF20">
        <property type="entry name" value="ZINC FINGER AN1-TYPE CONTAINING 2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25403">
        <property type="entry name" value="zf-C2H2_ZFAND2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AN1-type" evidence="8">
        <location>
            <begin position="3"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="AN1-type" evidence="8">
        <location>
            <begin position="92"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="193"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="245"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0739111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="30340" checksum="05A7B0F305C6481C" modified="2020-08-12" version="1">MPLDIGEHCAKPGCNQKDFLPFSCDCCSGVFCLEHRTYTAHACPNAGSKDSRAITCPLCRATISLTNDQDVNLVFDQHTRTNCNPDQYNEKKKAKARCEAESCREILTASNTMQCQTCRKKVCLKHRFESDHQCKGRQRHIPPTTRPAPAPSSAAQLPARLSAVGASVGSSVSRLVDNAKKAIPSTSVTASSESCPICQKTFKYTSQLIAHVNNAHPETSGRPNACPAPAAVAAPAPSSSANGVEACPHCRSTFSDVAQLIDHVERNHNSETRGSKSECIAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XGJ9</accession>
    <name>A0A6G0XGJ9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_005162</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000066">
        <property type="protein sequence ID" value="KAF0739243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XGJ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010076"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0739243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="357" mass="41738" checksum="D9F70BBEEA5173AE" modified="2020-08-12" version="1">MQSDGTTGRGTPDDAQLARRQYFQKKQREYRRRVKSKHRTLLEDFARFQNHAANRRTGDLVDYNGMLSWKVVASVFREASGDAKKKKTYLRDLTDANLALIYEMMRFLRACRPRPIASLSNAPPLHQHATLLAKGEARAHSKRWLAQQLYYNTDRFFDNFPAVDASDEFVDCNAECAGPWVNSIETCQVTWPFSVEEVKELFVRPEHQTSVCDHANAGFERDGNTVVTYGLDDDNDPWHYLHGYFYEADRFVVIFRRIHDDEAHLGPGDPDIHEFQWIDIRRLSATRSLVRFLTHRSNLLEDLREYARESREHLKHEDLDEKTIEREVAARDKEILWKFQQDLHDALARLSTCSIHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XH38</accession>
    <name>A0A6G0XH38_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_004697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000063">
        <property type="protein sequence ID" value="KAF0739514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XH38"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018957"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35213:SF5">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35213">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0739514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="230" mass="26806" checksum="64610BBE697DDBF0" modified="2020-08-12" version="1">MLAAKRLKERDGPWTDEEISYVRRLSLDFKAGLLPDVPRGTSIRPWLARKLRCDPMRISKKFKKGSKLLGIHKYKFKEEIFNGLSPEIKHMRECELKALEAKFEEKVELDRNGGIHRRRRRRKNNQAKEADAHQDGVSVAATAEPNAIETIIPVFEMPFLHEDYQEIELLLDDVIMAELAAMDKQVDYTTDFSVAYEHFPLKTFRPVHPDWTGMFTFGDDSYDYYNVIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XH41</accession>
    <name>A0A6G0XH41_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ae201684_004796</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000063">
        <property type="protein sequence ID" value="KAF0739622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XH41"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004197"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000251">
        <property type="entry name" value="ABC transporter B family member 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000205">
        <property type="entry name" value="ABC transporter B family member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000018">
        <property type="entry name" value="ATP-binding cassette subfamily B member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF27">
        <property type="entry name" value="ATP-DEPENDENT TRANSLOCASE ABCB1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="56"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="703"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="747"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="853"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="934"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="964"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="60"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="392"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="705"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1029"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="8"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF0739622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1273" mass="137266" checksum="D0E30498BF0B862A" modified="2020-08-12" version="1">MPKIFVASSAMKPHGNEGEVAPEVAQDGSSRHKKKAAKGEMVSFRNLFRYADETDYTLIAIGTVAAIATGIAQPLRILLMGNVVTAFNPVGGSYDSMVDQVAKISINFASFGVGVVLAGFVQVMAWTYTSSRQAERLRVAFIAGILKQDIGWFDVNNSQTLSTKITESVLLIQDGIGRKVGDYWNSIAMAIAGIAIGFKSGWKLSLVVVAFLPLLVLGLACMMKTTSRAVQNAIKAYGQAGAAAEESLSNIRTVHVFNAMPASSTKYNLALRVAEAAGIKKGLMTGIGGGFTFMMIFMTYAVAIAYGAVLVASDNLSATRCTSDCYDGGKVLTVFFGVIMGAMALGQANPSMEAIVSARAAAFEAYATIDRPSKVDALSDDGIKLDNVNGEIDLVDVEFQYPSRPHIPVCKGYSLKIAAGEKVALVGPSGSGKSTIVSLVERFYDPVAGIVKLDGVDLKTLNPRWLRQQIGLVGQEPCLFADTIAVNIGHGKPNATIEEIHDAARRANAFDFILSFPQGFDTVVGDRGAQLSGGQKQRIAIARAIIKNPAILLLDEATSALDTESERIVQESLDALLDTRKRTTIIIAHRLATIRNADRIVVLSQGRVVEQGSHDELMELQHGEYRMLVEAQSRKSPKKAASLQSPPRTTLAVSATTGASMSTHVVVEKEKAVPPPPPPPSAKARIVVPYRRIWALSQAEWKYLVLGMFGAVVTGATFPLWGVLLSQCIALFFNFRLSENDMKTQGLTWAGYFLVLGVAYCIGNVAQNYGFSVVSERLTARLRAMGFQAMLMQEIGWYDAPEHAAGALQASLSTDCALIQKMSSDLLKNVLNVVVCLSVGFSIAFYHSWQMTLALLGVFPLMGFASKMRAKTFQPQQNKESEIQGDLLAGALLSEAIGSIRTVASFGMEEAIVAKFCSHVATATAETRRSAAKLGVVFGLSQAMMFFSMAFLFWFGGYLISHQIILFSDMFTVLMALMMSSFGLGTAAQSLGDSAKAKQATANVFAIIDRQPTIDCDAGTKLATVVGRIEFQNVRFAYPSRPHSMVYKDYNLVIEPGTTVALVGSSGSGKSTAIGLIERFYDPLEGRVLFDGVDIRSLNLTWLREHISLVGQEPVLFVGTIADNIATGKPGSSQDEIEKAAKMGNAHDFIVQFPDGYKTQVGDRGIQLSGGQKQRIAIARAILRDPEVLLLDEATSALDNESERIVQESLDALLEMKKRTTVIVAHRLTTIQNADVIAVANDGRIVEQGTHSELMEIPSGLYRTLVSRQVQVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XHV5</accession>
    <name>A0A6G0XHV5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SBF1/SBF2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_004886</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000063">
        <property type="protein sequence ID" value="KAF0739719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XHV5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018181"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039872">
        <property type="entry name" value="KIAA0513"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022096">
        <property type="entry name" value="SBF1/SBF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13663">
        <property type="entry name" value="SIMILAR TO RIKEN CDNA 6430548M08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13663:SF2">
        <property type="entry name" value="SIMILAR TO RIKEN CDNA 6430548M08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12335">
        <property type="entry name" value="SBF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBF1/SBF2" evidence="2">
        <location>
            <begin position="342"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0739719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="515" mass="58911" checksum="2B469DF0E2407038" modified="2020-08-12" version="1">MQDLLADEENESRRTFCQMPFDAIYENAEKGGRSVANLLDFIAKKNIAERKCAETMLQHLQDIGGYRELSELEEPGTSTKRVLTELQHYFQTMNTQYLVWAQVVEEHVARPLDSLKGESSKYIQNLQVELSRVNDEYNEAEAQQRKTKSVCDAAKQDLLSAQVRQEDALHEIGVPSFELQRLASRVQKCELELTRALAEKEQAKQILLKKIIARDEMSMAISGAYQRAEEERMDQMAACMKVWLAVEQEHIRFREKQLRQLEDHIVRMDRAGDIQLVIHNHRNPDNMHFQGKALSLLDWQLKQDVAGVKSVLKPVADANSDEMDALVAVHFESEQTEEKDLQVVESVTKLCDSADGRQCFVKALNRQRSLVTKVPTDGQFRSLVNCFHAFFDACVQHDDTKAAKTAMMLSATFYSTPDHCDEDHHRIERRYIQEEVKGHTIWSNPKFWEKALLLAVGEELHKSPQRCPWEDLPTNVPRSEGRFTREEAVSHVHNIVFGQLGSSATSSRPCASPMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XIB4</accession>
    <name>A0A6G0XIB4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_004584</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000058">
        <property type="protein sequence ID" value="KAF0739883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XIB4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011874"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058565">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013935">
        <property type="entry name" value="Trs120_TRAPPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058563">
        <property type="entry name" value="Trs120_TRAPPC9_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512:SF5">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26254">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08626">
        <property type="entry name" value="TRAPPC9-Trs120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trs120/TRAPPC9 N-terminal" evidence="1">
        <location>
            <begin position="16"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 first Ig-like" evidence="2">
        <location>
            <begin position="718"/>
            <end position="854"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0739883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1220" mass="134116" checksum="11B4922A23B93A97" modified="2020-08-12" version="1">MQGSRHGFERNCEMLVYIIPVGNMPMHLYQGYVAMLQASAVVPMSSLSRPGGYSSELSPFRSLSWESSRSIVYRFEETSKASSIACEDVHASNRPLAIIGLCHCPTTGDLRQAYAHFERSAARYPTAIVHKCFAFEHAFGAGTLEDVSTLDDLVMFPLAAPLSDGHTTVSLHLQVVLDAITVTILMSLESTVRSALRQHLQGTIDTASDAGFGLLNTQVEPSFASQESTGIHATVSLHLPNNTVPTQIGRTASGNIMGSSSSIISGVTGLDKDARARKRMMYRQKKLVGDYTNLVGCYQDALDYYISAIDGLRDEEKRVSSTFGDTLWLAAALEGYLTALYMTMQEASSNGSLKFNVELVDKASEAISQYSRAHCHGLEARLIGCMGWYYVEVSSSSRIQEEAVWMRMLCLEAQNRMLESFIVALTSQQQQQQQQQHLEHLLDLARMSQSMGFTRKQSLYLHEAANVLFFRHRHTIPASTGLQAALLLAKFVATIQPTWLSLRFQALRQLIVTARKLHQADLVVQSALSLLGVLSQCPVAIDEADAIITCSWNEPIGTPWSYQTVVNGAGGPTSTAVALHIKPSVYFTPPASIEKEMKKLPHTNYFKGLPAALTAQASASTPRLLATPRQLMSAVMNPTTTFGGNGTVLMDPVTEENTPTKPSATADASSDVITTSRGLRLDALNHISQWQQACWLLLMEDAKAKTSTNFSTDGLVVVRSLELTKDTSSEALQTLDNVKTILTRHGNASLSTSSSAFFYNPFQAKETKPKPTVSSLMFPLHEPIEWTLTLDNPLDISLTLPRIHIWLEDSQTGLAFAESVQLSPQQTNTTVRLGIRPTQIGRLVILGCMVHLKQQSLRYSLDKPIVLDIVPALPQLNLSVDNVPCSETCQAALSLFEHEDKNVSVELRNASGVNAPHLLLEISLQRKGSHQSHSVSKVLVISLELDEQSNSSAQSNPTELTIPGFTLVCTMDKDTGTMPSQSTLGLRLHLLATKQDVVSITFRAIYCDEPTHKRLYKQSKWTLDVTVQAGIAILAMTPLHDAIMADMFNPSALTTFQVVQHDSTIEVPPQSVVRMPLATTDLKWKTSSASGSIPCTLPESQTPWTIRMTLGNSDKKIVSLQRLQFYEICLHVEQKLSAMMPPPLMVEIHVEEESPEGTTESSRDKVIVAGQCEPRFESSTIHSIQIMLVEHGLFQIHAVGRWNQQLEASTIESILKVQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XIY9</accession>
    <name>A0A6G0XIY9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_004410</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000054">
        <property type="protein sequence ID" value="KAF0740178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XIY9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017106"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15841">
        <property type="entry name" value="SNARE_Qc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="4">
        <location>
            <begin position="29"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0740178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="156" mass="17565" checksum="6B658230B98A852C" modified="2020-08-12" version="1">MDHRGHTRAEAEPPYEAAETPRHIALTIQEQERRHDEDLVEILAGAKRTKDLAKGIHTEVQSQNNMIDDIGREVTRATAEVEREEKKAAAVNKLRGKLWKLYLAIVLLTLSLIILSQLNFKVALLLSPLELNEVKDSSTKHSLQIRSTIALVMAKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJP5</accession>
    <name>A0A6G0XJP5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Intraflagellar transport protein 52</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_004068</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000051">
        <property type="protein sequence ID" value="KAF0740522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJP5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013616"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23683">
        <property type="entry name" value="IFT52_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12140">
        <property type="entry name" value="Domain of unknown function DUF4159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039975">
        <property type="entry name" value="IFT52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055460">
        <property type="entry name" value="IFT52_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055458">
        <property type="entry name" value="IFT52_GIFT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048643">
        <property type="entry name" value="Itf52_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12969:SF7">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12969">
        <property type="entry name" value="NGD5/OSM-6/IFT52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23352">
        <property type="entry name" value="IFT52_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23355">
        <property type="entry name" value="IFT52_GIFT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21178">
        <property type="entry name" value="Itf52_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IFT52 GIFT" evidence="3">
        <location>
            <begin position="22"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="IFT52 central" evidence="2">
        <location>
            <begin position="299"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Intraflagellar transport protein 52 C-terminal" evidence="1">
        <location>
            <begin position="390"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0740522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="492" mass="55303" checksum="A488A746CF5F067D" modified="2020-08-12" version="1">MSEGPGYDESLKVAAGGVSTVVMFDASKKEEFYPSSGYKKLARKLKTMYKIEVNKDDLSPERLKQAHLIVFSGVRERFSSSEFQALRDYMREGGSLLFCMGEGGEKDTNLNSFLKEFGIVVNPDAVIRTVYHKYHHPKEVYITSGIVNREIARVANVMSGKGKDIFARDPAADKAHGMEKDQKGLNFVYPYGATLNVKKPAAPILSSGFISFPMNRPIGAVWAHDGVCAPAKEKKNGRLAVLGSLHLFSDDWLDKDENSRLQDILFRWLLKDKEIQLDPLDAEDPDLSDYNRLPDTQALSERLRSCMQEGEELPKDFTKLFDNTLFKFDTSLIPDAVALFKELGVKHEPLSLIPPQFETPLPPLKPAVFPPILREPPPPALDQFDLDEHFASESLRLAQLTNKCSDDDLEYYIKESAGILGILPKLDPERNDAKHVLEFLFTKIVNFKKLNQDAQIVLTMPNEDKSSSGFVDSMMLADEKDNFEDEAKISSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJT0</accession>
    <name>A0A6G0XJT0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_004128</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000052">
        <property type="protein sequence ID" value="KAF0740391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJT0"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0740391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="78" mass="8932" checksum="D3D9F2FCE947F171" modified="2020-08-12" version="1">MPTFKHLFDTWAFTDAPDESKGMSIYSDEDMDDFMLHREGRRPGASKKDEASLFQQDATDDFMFYRGNGNRAQGAEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJV6</accession>
    <name>A0A6G0XJV6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">50S ribosomal protein L5, chloroplastic</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Ae201684_004203</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds 5S rRNA, forms part of the central protuberance of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit; contacts the 5S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000052">
        <property type="protein sequence ID" value="KAF0740469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJV6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010454"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1440.10:FF:000004">
        <property type="entry name" value="60S ribosomal protein L11, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_uL5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_uL5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020929">
        <property type="entry name" value="Ribosomal_uL5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_uL5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057266">
        <property type="entry name" value="Ribosomal_uL5_euk/arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_uL5_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003258">
        <property type="entry name" value="PRK04219.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="RL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00358">
        <property type="entry name" value="RIBOSOMAL_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9 13" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL5 N-terminal" evidence="14">
        <location>
            <begin position="7"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL5 C-terminal" evidence="15">
        <location>
            <begin position="64"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00035391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF0740469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="172" mass="19762" checksum="2156E3E96D50725D" modified="2020-08-12" version="1">MSNGKNNVMREIKVEKLVINCCVGESGDKLTRAARVLEQLTGQKPVYSKARYTVRTFGIRRNEKISCHVTVRGEKALEILDRGLKVKEYELKKRNFSDTGNFGFGIEEHIDLGIKYDPSTGIYGMDFFVVLTRAGMRVARRKLRQTRVGAPHRLRKQDAMNWFTTKYEGLIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XK40</accession>
    <name>A0A6G0XK40_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_003919</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000047">
        <property type="protein sequence ID" value="KAF0740685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XK40"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004661"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019784">
        <property type="term" value="F:deNEDDylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044613">
        <property type="entry name" value="Nep1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46468">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46468:SF1">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="5">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0740685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="172" mass="19634" checksum="FC904BD0E1AB2DE2" modified="2020-08-12" version="1">MTYHETCEARSDILLMDPAVVSCMMLQCDDEEDLRDLAQGLQLREKSLILLPINDRQNFDSQGSHWALLVYCTDNGFQFYDSSSNHNRESAEEVAAVLQRAIGLPTSTVAIESCPQQQNAFDCGMYVCLIAEWLCRSRLGLEQLSLKDYVTPKRIRETRQAMPDIVQHLKEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XLG4</accession>
    <name>A0A6G0XLG4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">pectin lyase</fullName>
            <ecNumber evidence="6">4.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_003548</name>
        <name evidence="10" type="ORF">Ae201684_003551</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Pectinolytic enzymes consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Eliminative cleavage of (1-&gt;4)-alpha-D-galacturonan methyl ester to give oligosaccharides with 4-deoxy-6-O-methyl-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.</text>
            <dbReference type="EC" id="4.2.2.10"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.10" evidence="6"/>
    <dbReference type="EMBL" id="VJMJ01000039">
        <property type="protein sequence ID" value="KAF0741214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VJMJ01000039">
        <property type="protein sequence ID" value="KAF0741217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XLG4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011985"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047490">
        <property type="term" value="F:pectin lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002022">
        <property type="entry name" value="Pec_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045032">
        <property type="entry name" value="PEL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683">
        <property type="entry name" value="PECTATE LYASE 18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683:SF67">
        <property type="entry name" value="PECTIN LYASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00544">
        <property type="entry name" value="Pectate_lyase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00656">
        <property type="entry name" value="Amb_all"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033881783" description="pectin lyase" evidence="7">
        <location>
            <begin position="21"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Pectate lyase" evidence="8">
        <location>
            <begin position="105"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00036818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0741214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0741217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="390" mass="41829" checksum="88334448D0B18463" modified="2020-08-12" version="1">MKFVAFIAAIITVATESVLGASVPGLAAGTTGGGSAIPVYPKTIAELKFYLNDTIPRVVILNKAFDFRGSENTTTETGCRPERMRKCIAKNNGFLGQDVILPTGDMNNTGGCTNGEPVSVTYDNAAAKSRLVIKSNKTLRGEGLKGVIVGKGLWLNGDNIIVQNVHVTNLNPQYVWGGDGIFIQGFNNRAMKNIWLDHVKVSLVGRQMLAINKGGVDSLTVSNSEFDGQTTWSASCDGRHYWTLYFNGNATASFINNIVHHTSGRSPKVAGATSFVHIANNHWYNNTGHSFEGSTGAYVLSEGNYFENTLVPNLMDNSSNVMSTTDANKASCLTSLKRKCVPDVFVSSGAFNNTNENNVPNHMNGVATAYKPRGAAKLTKSTKNFGVGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XM65</accession>
    <name>A0A6G0XM65_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CCT-theta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_003492</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000037">
        <property type="protein sequence ID" value="KAF0741383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XM65"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010577"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03341">
        <property type="entry name" value="TCP1_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000008">
        <property type="entry name" value="T-complex protein 1 subunit theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012721">
        <property type="entry name" value="Chap_CCT_theta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02346">
        <property type="entry name" value="chap_CCT_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0741383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="561" mass="60447" checksum="1BBAF88BC0FEE486" modified="2020-08-12" version="1">MDHRNFHPSPSTDRVNMAKSMGFNPAAGLSGLLKDGHKHFEGVDEAVAKNIDAVKQLADISRTSLGPNGMRKLVINHLDKIFVTSDTATIVQELEVVHPAAKMVVMAAKMQQTEYGDATNLVVSIAGELLMQAASLLRMGLHASEVVTGYKKAYEKAILILDTLEVHQIRDLRSQTELETIIRPVVGAKQYGFEDVLGTLIAEACLNVMPNKPKAPKINVDNIRVTKIMGGNVFESQVVKGMVIQRDTEGSVKKAERVKVAVFGCGIEVSSTEAKSTVLIKTADELMNYNKGEEERLDEAIRGIAESGAKVVVAGGSISEMALHFLEKYQLLSIRIQSKWELRRLCRAVNATALVRLGAPTPEEMGFCDHVQVQEIGGKKITIFRQDEEDAKMSTIILRASTDNVLNDLERAIDDGVNTVKAACKDGRFVAGGGATEIELARQIEAFGNTTPGLDQYAIKKFAEALEIVPRTLAENAGQMATQVISSLYAAHGAGKAQAGVDVECESESGVVDNMLAAKVLDHLETKKAALRLGADAAITVLRVDQIIMAKAAGGPKPRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XNM4</accession>
    <name>A0A6G0XNM4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_002766</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I NDUFB7 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000030">
        <property type="protein sequence ID" value="KAF0742092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XNM4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000178"/>
    <dbReference type="OrthoDB" id="268414at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008698">
        <property type="entry name" value="NDUB7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900">
        <property type="entry name" value="NADH:UBIQUINONE OXIDOREDUCTASE B18-LIKE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05676">
        <property type="entry name" value="NDUF_B7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0742092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="85" mass="9895" checksum="3ACD8D1B82B3DD7E" modified="2020-08-12" version="1">MAHGHDDHHGEEASTIATRQAMADARVPLAYRDQCSGILIPLNECRRETAFAPWKCQDLRHAYEKCQYDEWKKRIQILKESKKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XPU9</accession>
    <name>A0A6G0XPU9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GPI-anchored wall transfer protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_002555</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000027">
        <property type="protein sequence ID" value="KAF0742457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XPU9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009361"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032216">
        <property type="term" value="F:glucosaminyl-phosphatidylinositol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009447">
        <property type="entry name" value="PIGW/GWT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06423">
        <property type="entry name" value="GWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017321">
        <property type="entry name" value="GWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="356"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0742457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="479" mass="53440" checksum="04C5A0A6F953C6E8" modified="2020-08-12" version="1">MEAAAELSAEDAYKKAKEAFVTGHNGTTMGEVALVLSVLSTSLWFYSELVFVIEKYGLLGKSKLRRTLSLLLIEFVTLVLPILIAFTFTEYTTPITLFFAVGAVVLGVLSWNNATEVERKAARKDKLTFLMSKEKPAVTCFRAQMMICTCVAILAVDFTIFPRRFAKTETFGVSLMDSGVGLFIMSSALTSSYARGSVTKRSSSSFSLRAIWHFFRPMIPVLVLGVIRYVTVKKVNYQEHVTEYGVHWNFYLTLASLYFTFSLLALFGSYATSVPAALILLAAYQYGLLYRGIEDFIFNAPRVDLFSQNREGIFSLCGYLPLYLLSVAVGQIIFADSAGSASRNHIRADRWTVGSLFLVGFTTWGITHLFSTHVTEPSRRLLNIPYVGWILWQGILVLTTHSAYQHISLSPRVPLIFSGISHNQLFVFLIANLMTGAVNLSMQTIYAPTEVGMVIVGLYMFAVCVLAVLLEWFHIKVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XPZ0</accession>
    <name>A0A6G0XPZ0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">rRNA biogenesis protein RRP5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_002732</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000029">
        <property type="protein sequence ID" value="KAF0742330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005275"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05693">
        <property type="entry name" value="S1_Rrp5_repeat_hs1_sc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000065">
        <property type="entry name" value="Programmed cell death 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000103">
        <property type="entry name" value="protein RRP5 homolog"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000196">
        <property type="entry name" value="rRNA biogenesis protein RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055430">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045209">
        <property type="entry name" value="Rrp5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057301">
        <property type="entry name" value="Rrp5_OB_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057302">
        <property type="entry name" value="Rrp5_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048059">
        <property type="entry name" value="Rrp5_S1_rpt_hs1_sc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 11 PRE-RRNA PROCESSING PROTEIN RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270:SF10">
        <property type="entry name" value="PROTEIN RRP5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23231">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24685">
        <property type="entry name" value="OB_RRP5_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23459">
        <property type="entry name" value="S1_RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="S1 motif" evidence="9">
        <location>
            <begin position="84"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="9">
        <location>
            <begin position="177"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="9">
        <location>
            <begin position="266"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="9">
        <location>
            <begin position="351"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="9">
        <location>
            <begin position="452"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="9">
        <location>
            <begin position="541"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="9">
        <location>
            <begin position="630"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="9">
        <location>
            <begin position="717"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="9">
        <location>
            <begin position="1117"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="9">
        <location>
            <begin position="1293"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="9">
        <location>
            <begin position="1380"/>
            <end position="1448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1449"/>
            <end position="1569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1453"/>
            <end position="1526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1546"/>
            <end position="1560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0742330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1861" mass="203751" checksum="9356FC93552B4F7A" modified="2020-08-12" version="1">METSFPRGKKAKTEDDASKKRKKSSDTDVLFGKKDKAADETVASDAKPKRAKLKAKDDVAVAKKEKEAKPVLANVITFKTLRPQMLVMGVIRQINDNDVVVSLPNKLNGVVVRNETSDELHNAKNDTGNLQDIFYVGQYVACVVLKVSKDDKGKRIELSLRTSLLNANQSVKHIVKGTSLYASVVSVEDHGVIMNLGVRGMNGFIATKDLHLPEGQTECHPGQLFFCAVSSVNNHTNIATLTTERTTTVKTITRGDSFTVSTLSLGMLLNLKVEDVLSNGLQVNFLTFFSGTVEYNHMSNPCQNDWAAAYSKGLKGRARIIAIDSTNKSIMLSMAPHIVHLQPPDFKEAIGDVIDAAVVHRIDNGIGLLLSLAGEASSENERLSWKEFRPAYAHISRCADTRVEKLDKHFKVGDVVPARVIGYCAFDGIVNLTLAPSELSKAVLRQADLVPGSIIKGKVATVESWGILVDICDGVRGLVNSAHAPSVALKKTMSKYKPGHAIECRVLKVDVASKKTYLTLKKGLVSSDLTPLTSYEQALPGTLAHGFVTKIAEFGVVVGFYDGVHGLVPAATLRKAGVDDIAAAYTSGQVVKVAVVRCDPAKQRMTLTFDTSAVASSKQTNSSATTVAAGSMTHCTVVECEDGFVRVQRTDGLEGVVPHAHLTDFPRLFQPSVAVGDEFDALVLYQSSDGLLHLTKKPTLIRNVSKMPSKLADVSEGQLVTGFVREVRPFGVFVSFLNNLQALAPISFLTDRFVSKPDGLFQVGDTVQCYVEKVNEDKGQFLLDFRVKNPPTPDCLNALLAQQAAVHAPVVSHSVGHTEKAEFVSAKAYGHVCTLTDETTVVVQSTENLDWSENDSVKLRLIDYDFDKQVFYGHAAPSDFVKAGEKKGRKQAARLAKGEEVDGVVLLLRDEYAIVQVGTAVALLQVMSFQQPSASCESLNLEVGQTLKCIARGYTKNAAPFDELPVVVLADSSARAKKQPTKPKYEEHLPKYAGPELIVGATVTGRITGIKEDSMELKLKCNKTAGKVNAFVSIVDVDAQPTQDHPFDAFATNSVVTGRIVSLVEKGANQRKPVSEKNPANFRSINISLRKADQNTAKPVGPRPDWSDEGYEVLQSGRFLPGVVVETTTDGLLVRLSARVVGFLHVLELSSDLSALESFATSFPVGSPLKVRVLSCDPEKKTLDLTCHKAKKGRMAVGDIVLGRVNTKVNALAAPSVMIQVGAHAFGRVCVTEVLDTQKTMPLAELVHGTFVQAVVLSSTPSLELSVKPSAIADPTEYVSKDAEAAGKLPELGSIVTGYVATVGSGGCFVRLHRSVTARVLLRDLSDDFVKEPAAKFPPGTLVAGRVTKSEEGKIEMSLKASVVTEGGAGQVTLESLKVGQTVKGTIGSIQPYGVFIRLEKSTLSGLCHISEVADSKVNSLDGVFSPGDYVKAKVLKIENRRISLGLKPSYFENEESSEEEEEDDEEEEEEEEATEDVDMEGEGEEDEEGEEDEEEEDGDNEEADEEDEEENEDDDMGQEDEEDTIEAPQADFTWDGFSIYQPATEEADDVEEEDEEGEDEASKSKLKRMKKKLKEHEDMYVAYRERALASGESVPESADDFERLLAVSPQNSFLWIQYMAFHVSQTDIAAARDVATRATSKISFRDMQEKFNVWVAFLNFEHDHGDEESFKRVFNSACRANDPKKIYLQLIEIYGRHNQVDDVLSTLKTMQKKFNTSAKVWLSGLKWHMSHGEAPIARQLLQRSMQSLPKHKHLKVLTKFALMQYEHGEQEHGRTMFEQMVASYPKKMDLWNVYLDREIKFGTQESTRLLFERALALPLSAKKMKALFKKYLSYEIDHGTDASVAHVQQLAAAYVESSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XQF8</accession>
    <name>A0A6G0XQF8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WRKY transcription factor 19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_002452</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000025">
        <property type="protein sequence ID" value="KAF0742753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XQF8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003398"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827:SF1">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0742753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="188" mass="21606" checksum="D0BE07075A45973A" modified="2020-08-12" version="1">MVITTAKCFFEGCNKPVEAHSWRCAFHKGRDRCSVVDCRRQAYARKLCTRHGGKTKCLVEGCMFQSRSMGLCAKHGVKRKPRLCCVPDCGKTAHSRRYCTRHGDGGRCNAPGCESYARRAGVCCRHSNPPRKRWEDDVKMDEISMVESFVELFNTEDLVDHHQERHYLEWKKSIHPVDLGILHVVNHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XRX7</accession>
    <name>A0A6G0XRX7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ParB-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_002182</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000022">
        <property type="protein sequence ID" value="KAF0743125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XRX7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015825"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16400">
        <property type="entry name" value="ParB_Srx_like_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1530.10:FF:000008">
        <property type="entry name" value="12-oxophytodienoate reductase 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1530.10">
        <property type="entry name" value="Conserved hypothetical protein from pyrococcus furiosus pfu- 392566-001, ParB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB_N"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="ParB/Sulfiredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB-like N-terminal" evidence="2">
        <location>
            <begin position="146"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="ParB-like N-terminal" evidence="2">
        <location>
            <begin position="437"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0743125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="574" mass="64973" checksum="073EF89F309F6CBE" modified="2020-08-12" version="1">MLRERSASTSSHQPAKRQKSNSWDDTEGQIEAIEVPRRRKRDVLKQVSMRLFLSAQGYTSDILRTVFSQFDGQERETAPEPEPASAPSRTRKYWMPQTQDDATLSVSHANGLNVNMNFFLSRYTDPTSYFYKFHDTQREPRKAVVVLVSLSWLKPHEEIVSWERVNGLKNATLKWNAYTEPLLVDIKTGAILDGHHRYTVGLQLELKQLPCVLVDYLGDDLIMVDVWPDCGRTSLTKREVIDMSLSPNVFPPKTSRHRFTDSLPPISIPLDALRAEPTEGTIGYECPAVSLAHEEIGSLTVASPGRFSKRKFVLETSISLLNGASNLATTVVKSLFRHRIREIDENKKSSTTLDLVTRTSKKDPNRSGVFDAIRANDPTSSFSRIKGRMAQTLDDMIDSGNTYRKFFVSRITDPTSYFYKYRLDTEKERSPKRLKVVLVLVSWLKAHEAIVSASRVDGLRRATVKWDAYLEPLLVDRKTGAILDGHHRYTVAVQLNLVSVPAVLVDYLEDDSITVDVWPECGRDSLTKAEVIAMALSDDVFPPKTSRHAFSDDLPPIKIPLEKLRQPYFAEVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XSK2</accession>
    <name>A0A6G0XSK2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_001724</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000013">
        <property type="protein sequence ID" value="KAF0743579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XSK2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012653"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0743579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="282" mass="32405" checksum="03A865EA6CFBDA3F" modified="2020-08-12" version="1">MKEHTLKSRQDFYTIHVGAVPPPAPLVQKKSGAMAIHWILAPTWLAWGVWTWTAAFELINVVAFLTVGAILAMWTTVANMPTHAEELHVTRFFQPWFSHIFRPRTPSVQRHDDSEWIQTRLRRTVSTSSSESDFEYAVRCSESTVAIDDDYEMYQEEILHQQSIPEEDDDEWVSTPSESLNSWLVSQPEFQPEYPPVQPPAPVKRKRADSTTMEPPVTKRITKTPVKRILKSSLCRSPEIRRMMEDLERMQDEGDALVMAAEAVGIGARCTMNERLRRLGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XVQ1</accession>
    <name>A0A6G0XVQ1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Biogenesis of lysosome-related organelles complex 1 subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_001038</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BLOC1S2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XVQ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016610"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019269">
        <property type="entry name" value="BLOC1_su2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10046">
        <property type="entry name" value="BLOC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="75"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0744567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="12873" checksum="AB31C4AF75F308AC" modified="2020-08-12" version="1">MAAPDDRVLELTTRVTDSICEYIGVELEGAIERTKLVDKVMHAIHDRYDKMATESANVALFSKQLKESEILFQDRMQAIDEVDEELTELEDMIQQLELYAQRIYEKFTVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XXT6</accession>
    <name>A0A6G0XXT6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_000443</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XXT6"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0745424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="91" mass="10252" checksum="FD4D7B98887A5C3B" modified="2020-08-12" version="1">MLEISLEGVRQSLVHSRRAGPLPSKWKRLSSMRGLAAPDRGASGHILYEIPYLLSVDVVDHRDGARFLALKSRRTSHYSSRFWVSSAIFCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XY65</accession>
    <name>A0A6G0XY65_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_000464</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XY65"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017278"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1470.10">
        <property type="entry name" value="Photosystem I PsaD, reaction center subunit II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053233">
        <property type="entry name" value="ABRA-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21715">
        <property type="entry name" value="RH04127P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21715:SF0">
        <property type="entry name" value="RH04127P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="3">
        <location>
            <begin position="92"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="175"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1002"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="294"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="456"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="723"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="883"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1005"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1018"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1032"/>
            <end position="1043"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0745448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1094" mass="124495" checksum="FDC696DE087138D8" modified="2020-08-12" version="1">MASGSAMLDRWGFGGSAARTASCAFPRRGRAIARQDGFKQSRVTVTVAIAASSMDKSSPEYKEAVREHAKTLGLDPDKEPQYLWIVEEALSAPLPSNWEQGETDDGTIYYFNSETDESIWEHPMDSHYSEMIKTKRAEDAAKKTAPTAASTAAAVFNNAPKQQPASSAIQAFSLDDADDDDVPTTTKQQPKSKKTEVKKPATTTTTTTSSTTKAAGFGKDSQSWLLDDEDDFPTIPTTKPSIVSAIKKQDDVPKAAVFIKQATPPVPTISPVPATSSVLSHQIPTQPAPAVAVNHELEKQVETLKAEITQLKKEREANEKAERQVKTSLQQQVDALRRGKEQAEVEAKESNYLRMKVNELKAKVTALESKNDGADSSVLQSMAEVEAKLDAARRELDAKAQQVDQLMEKVAQGQADCDRQLKKKDDELAMKIKEHSIETEELKDQLLMRQATNITLQNSATDLDRWKKKATELEDEVRRVQGQLTELTTSTADMRAAFEAKEKTFTLQLDAQVNKLAACEKELSSARQQLLTVEKERDEHAKAVDQRETEKTYLEQILEQTKAELQKTKGQLDDASKRIKTLEESSWSATNDAENVKRAHERELKMLQDKVVEATRERDDAEARIKRQKEEHVHLQSKWQLDLEELRRDKERSCAQTTEVQALRKEIESLNIDLARIRDQKTTTDHDLRNLKQAMSLETSQLMQCKAQIEDWVRKEFLEKQRLELLANEKSAVEKKVMTLEAQLQTMRSEFRTETDKYLFRIRELESLNARYEYDLSRADEKFATAEKWRLKEASRVEQRDADILDLKEELGRLKARNIEGENNHVINELRATAKTLDAQVKELKAQLQDEVATKASDEWRRRCDEIVGKIKAEFEESWLLEKQKSSEREAAWHDEKRELEREIKTHASEKDFLNKEVSRLEDNNKHLMVRRGHADLAHHLDQEQLHTIRVYLTQRPVHSAMAPMYAAPSQPPCVNPEVVGSQQLQNQLGILHAQFQQFFQHSAQPPPSSSRPLHPPPRFEREIDPKERSSRVSSVEYTSPSSAQLLDEKKELIRSMEALGDDRNNDWVPLVDTAAVDGNNTWYRKGYWRSKYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XYB4</accession>
    <name>A0A6G0XYB4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ae201684_000512</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002464"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="616"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="839"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="897"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="1415"/>
            <end position="1438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="335"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="521"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="346"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="359"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="530"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="540"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF0745498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1512" mass="168930" checksum="E83124C58C9BA1F0" modified="2020-08-12" version="1">MREKRDGGRLVCVKDIPVSPYEKVHESLHEARLMEKLHHPNIIEYYDSILSRNHRHVFIVMAYCSGGDLHAKLCSKRKLVSETTICLWFVQICFGLHCMHAHRIVHRDVKSHNIFISTNGHLVLGDLGIARELEPSELAQTFVGTPCFLSPEVYQGSAYAYSSDIWSLGCVLYEMCTLHFPFVAKTTPALVDKICSGHVDPIDRQYSPNLRHLLSQLLSVQPSGRPSLRDILSRDFLRPALECYVTDVLKCCTKSHADIVQRQLGQLGLSAIYENVRLKTVKQDNNVTTILPPNRLVPTHSYKLEQDMLSWLEKERQRHLLLVLARIKEARCDQLRISPRPPSPTPGISIPESPSSPRHVPPLPDPQWRPPVQVDPFPRRQAASKPRTNPSKTPAFRKGVNLTPQAKPFLAQACKDVRALRREAYEAAAKARYRTTTSELLASPPKEADSIEDVAMATPAEIDEAMMQYQRDVERKLLQRVTSMHVFPLDTCIAVPPHIDAKYRERCVLQNAALAHRPTDVIPMKPTYSPKVQESAQARTQREKARQASHRRLVDQRTEERRMDSNETRKSHGDPRAILVHLDLDAIAKKMNKTDEVKMSKASFMEILVSLLKTRVAMEELDRLFVKIDHDQDGCVTWTEFTDFVLDVMRGQSDRRPREGMHEFDKTPIVAPAMVNRSMDKMVSTDDGSFLALEHRSNVFQVVDAVSGTVRKISSPCTRGYLIDLALVPPLNYIAASTSNTTIEFWDVDELVVRQQLPTTQVQSVVRWNSTRLYTGSLTGEVQAWNCETLDCTGVANLHEPTAITDMTFLGPQPHAVVAAFLPEIAVLDLTTHKPLLKLQGHRSGVSFLRYSPSYRYVLSGGMDHDLRVRVFLDGHSNLHDRSYGVHSWERALQGCQASHQHQIMGLTWVDDSPEVHSADEGGFLKIWDLRTYQCVQTLSTLGFSSHLSTTAITHTMESSKPSVVRSKPTSAMCHLRHQQRIVLASAQVKFYDAVKHDFGDKTAPTLVVFLPSILAIVTATGQNVRTWNAQTGQLMSDLKKIAASQIASGCAGGTSAVFLGTRSGHVFSLHALSGAILLSRDIHASEVIAIEKLDVPSLASRLVTAAIDGSCVVSDASSLAPLLALNHWHGINGFASTRTETTPCHDYYVPLQTARKFSTYALDNLKRFFSALDTNKRGFITSAQVPEVFNAVVSLNHRQCRRHNVYLEQIMAKLGDNNITFLNFLEMIHDTWHGTGYATSEVTAIGISQQHNFVITASVDGHFCIWHGSKGHAITASSQQVQGGITSVAVLEPHPIFAVADDHTGLSLFMLKSLRLERLANVAMSCTFTSLAWCSPRNLIAGDDEGHVTNWHIDGFFTEQPWQVEAVDTKSVSPTKWQQFKYSMGGALSEEASWPAHDGTVFALWACFIHGNGYVATCGGDGFVRVWDLDEENLVGTLVKGSKENALWNSNLPWRIASQLPVEDELVVQTEAREAEYEETFKESSFAMNVMGIRCAMRLKDALNAVRPTQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XYT4</accession>
    <name>A0A6G0XYT4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_000202</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="6"/>
    <dbReference type="EMBL" id="VJMJ01000001">
        <property type="protein sequence ID" value="KAF0745754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XYT4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019190"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051134">
        <property type="entry name" value="PPP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="412"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="494"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="534"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0745754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="584" mass="67585" checksum="4E3071FC191ABAEC" modified="2020-08-12" version="1">MILRAHPIDDDLRHWQLWCQLDCHDEAKMLKLSIFMQSLLDNISLEPAARDADMAVQGDIDLDNVRLHDVIHLEFPLDARQIETMTHAFKASADEIRIPLPKTAILKLIQSCTDYYSNQPNVIFLQIPRECTLTVVGDLHGQLQDLLYIFKTQGPPSPTNWYLFNGDMVDRGDCSIEICAILMAYQSLFPQAVHINRGNHEDPMLNRLYTFHREVLIKYDHEVDAAFNRWFTRLPLCYVVNHDVFVVHGAVSLMLETLIHRTINSIPRHEFCLHVRGSDSHSREMHWMQDLLWSDPRATLGHLPSHRGAGVLFGPDVSAQFLRTNDMKLIIRSHEAMKEGFLWPYDATMPMKGQKKSPHKCLSQYFHAQTIATAIIREPTYICRKTKATVSPPAFRSIEEHNRHNILQVIVAQKPKLREAFLKLDSGQTGKVTVQEWASAMKEVLELDLEWSRLASLFAHVENNLISYGDFLETYRTIYQEEKNHSVVFDALYSKRKEVEVIFCFFDTDNSGTISMEEFQRGCQLLNTHLPEEEQWNETDELFRLLSLSGSNSININEFFEAFRLLDNHHVSQPKIPVMTYPIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W386</accession>
    <name>A0A6G0W386_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_019076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000386">
        <property type="protein sequence ID" value="KAF0721558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W386"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003659"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044294">
        <property type="entry name" value="Lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482:SF62">
        <property type="entry name" value="LIPASE ROG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482">
        <property type="entry name" value="LIPASE ROG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF676" evidence="1">
        <location>
            <begin position="16"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0721558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="546" mass="61477" checksum="B8C39757E05CCFFC" modified="2020-08-12" version="1">MDSHQDMWQEVRVGSEDAVHLVILQHGLHGSPQDYSTFQPILQSVLRDHGVYVVSCTSNSKEYLTTHDGIDLGGLRLADEVEQIALQCPMLQKISFIGHSLGGLYIRYCVGVLYSRGFFSKVQPINFITMATPNLGIRRPPNKGTISNLFNVVSSRLFDRTGAQMTLRDTVSDETLSLASPRSLNFDQIPVFPDCSADLELQLPFPNEGYSRLYCTLHAHELNVYFSHLDVQQPPLFSFDLTEFDAVLFVPQEESSENAEHEGGDQSESYYNDVPRHRDIVLQLRTKGLGETAHVDIHVVTSSDWEFTHGCILRSGSVACVSYSGDKGSLRNEMVEIPRNQYLMQCLSQGAFLYGLYVFKRRVVYSNIFFDVQAPYSFSAFRSYNPYRHNAIPCATSAVYPHITLHSFINSTIFRESINLAKTDESEPKKKTWLHGLADIPAQLFPVNKNPTSPTHSQHRMFFVVSKDTEHVIVDSPEDAFSSDPLKDVLRGMLMAIQSLGWERIDVLFENALAHEYIVAKRSDDIPVSDSGIDVAHHVADTFLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W4P7</accession>
    <name>A0A6G0W4P7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_018691</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000349">
        <property type="protein sequence ID" value="KAF0722054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W4P7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018238"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF214">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026270764" description="Protein kinase domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="303"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0722054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="466" mass="48926" checksum="60B9D8C9F2EA5324" modified="2020-08-12" version="1" fragment="single">MRVGRMTLLAGIPLLLQAQQPPQTTTLTPAPTTTTIQPTAAPITTPVTTPVTTPTTTPVTTAQTTAPTPTATQLLLCSSYCIFEGNNNPCGSIVQTVKACSAGPTFLVQCGPTTCRVDPAARGPVNFTATNASQVEAICGVNATTAFCRPAVLSAANPTATTEAPETLAKSPSTPGTLTPSSSSSQESSSSHTGAIVGGIVGVLAVALIGFVFVKHRNRRAAKPSDSGDDVAMIDDVEAYVVSLTPSKAKPTHGASVLSHEESLPVMDTSSFVSMDVVSQDKRSLQQILSSREDLQPLWLPLEKLDTNPLKGGQPDLRVATYNGSKVALRCLDYASASSAKRTAFFASMQRLRPLKNPHLTSLLGVSLVGHQTQACVVTEHMSKGSLGSLLLASDDLSQKQRLTLGLHIALGVQYLHGRGLVYGGLHPDKVLVNNNLEAKLNLIHLMAPVYTPRRFCNASCGRANT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W552</accession>
    <name>A0A6G0W552_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helicase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_018654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000345">
        <property type="protein sequence ID" value="KAF0722175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W552"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005216"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005114">
        <property type="entry name" value="Helicase_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37066">
        <property type="entry name" value="HELICASE-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37066:SF1">
        <property type="entry name" value="LNS2_PITP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03457">
        <property type="entry name" value="HA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase-associated" evidence="1">
        <location>
            <begin position="113"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="1">
        <location>
            <begin position="359"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase-associated" evidence="1">
        <location>
            <begin position="441"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0722175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="516" mass="60114" checksum="FB60DA9B5F929FFF" modified="2020-08-12" version="1">MLGRLKVSRRLLPLQTWGVNSFATKIFSLEEQKQILQVAQCVYEMEGRPRRMTLTPTKYTVPTIEPFPEDLHGKKFDISQFRLAKKAGKLDVDIVAQFDAMGFYWNGKEYASERAWEEYLAALRIYESIYGHLNVPWGFKVKEGDAQWPEMYWGKQLGYAVGTLRSQQDTMDPARRQVLDSMGFIWDGVQANCKKNLLALETYKAIHGDLLVQSSFIVPDQDPKWPQDTWNINLGSLVYRLRDSKDSLLPEMRDKLNVMGFVWNIREKKIGSGRTLKISVAKQKQLLQVVEIQYKLQDHTEFTTFGNNFRVPSTSPWPEHLQGCNFNISTFRTAYRMNLLNRSIVAKLDAMGFVWDDNQHQWKLFLEALQIFKNIYGHVEVAKYFEIPAEDPQWPVYLKAMKLGIRVSNIRSRRTSLTTEMTQELDALNFVWDAEELHRQRVLLALTKYQELNDDLLVPQKFIVPEDDPDWSSDLANMQLGAIVNRIRSTKNSLPKEWKEQLNNIGFKWNARKKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W5G9</accession>
    <name>A0A6G0W5G9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_018581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000341">
        <property type="protein sequence ID" value="KAF0722249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W5G9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013992"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0722249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="212" mass="24203" checksum="82FA9CDD87FE45D0" modified="2020-08-12" version="1">MDKSVTDGPSRVLCLVRLFDKICTESGFPKYYEIEVEAARRYFLNALEPISVRKKISTELRFSKKRYMVWKDFVDLCIDYMKNWCMYEDVFKSDTRPEAKPEAKKKFDRPNQKPRVEKKKAESADTAASGDAKAKASKPSYICLKCQSIDHNVWKCPKLKDEAEAKSLLKAYYDAKRAAEPKKPNVDSLLSATGSDFFKAVCAGLEMKTGYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W5H0</accession>
    <name>A0A6G0W5H0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BART domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_018981</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000370">
        <property type="protein sequence ID" value="KAF0721701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W5H0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017887"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1520.10">
        <property type="entry name" value="ADP-ribosylation factor-like 2-binding protein, domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023379">
        <property type="entry name" value="BART_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042541">
        <property type="entry name" value="BART_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11527">
        <property type="entry name" value="ARL2_Bind_BART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BART" evidence="6">
        <location>
            <begin position="2"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF11527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0721701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="297" mass="34495" checksum="8131EA23067D0F20" modified="2020-08-12" version="1">MIRELMLFIAGAEFQSTFEAFFLKHALKFTDDEEHRLEYTQLFQEFQELFEQFMQQFYLKNNITEAEFGKRCRAAVKNDAKASQYLESHEENGTCIRAIEYHLQFTIFANFENVAKTWWFDLLEASPLVVSTVLDAIGEHIIYVSQEHSSLKYTRLCLAGIVMDEEKDRITITQTGIATDDRFPFQDGESRSNGFQWVVFQHVTDNLTLVRWSLLNFCPVNAKGPLSLSEMARNLRCAVRPNDSKESILMKIHIAVEGALGNLRDQFRHRCGRFRLEPPSTMGSRNFSMESLRHIHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W6A5</accession>
    <name>A0A6G0W6A5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_018761</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000352">
        <property type="protein sequence ID" value="KAF0722012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W6A5"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0722012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="118" mass="13842" checksum="2EFB03D4C35FCF8A" modified="2020-08-12" version="1">MSNCMPQSSTKEVRRSFCHTNARPNFLFHDSETWPRQIQSTTRNQTSAFGFRLCFPRDTKYTVIVARQGAVTALIRFRETNAHLFWTPCSIRANLAYVNTYNWISLRFLVDDALYEHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W6U7</accession>
    <name>A0A6G0W6U7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_018590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000343">
        <property type="protein sequence ID" value="KAF0722208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W6U7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006127"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF317">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="403"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="497"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="529"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="3">
        <location>
            <begin position="98"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0722208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="617" mass="68056" checksum="66AA3EB0A2AC3476" modified="2020-08-12" version="1">MYLYKNSTTERSPAKNILPLGQTDHRMQSSRHNMRDFCTSSWPSDLAQAVPQRRGICSWLGEYWRVTIPPKTSNELDAEQWLFVVGLPRGRFWSSRPLFFQRWYLALLTLLTQGIIGCIYSFNTMAPSIDRFFGVETNSIHVYLISTLSLGVAGALAGPFLERKGPRTGMTLGCVFFCLGLVLAQVAITVKSLALLYVGFGVLAGVGHGILLISSMSTLLKWFPDWRGVVTGICVAGMGLGTALWNTFYDNMLLTLPSGSNGPGSLNYLFALTAGVSLVILILSAMVLRTPPPTFTVNGHDIHSIPASAAPNHMLVQDEFLNVGMTLVNYAALEPRHTILSTDKEYFQQVKALTLVQCIFSTDFFWLFVVFAANLTPTVLFLPQVNDTAVMVLHKQPKDATDFLNRMTITTSIGVVVAPLLSDLVIRIFYANPAYARKMIFFIMVAVQAITLGLLMNKWKDLDSWLWYGVGFCIGGGFGVIPSLVSDMFGVYNSGTMYGLILTSRAVGAVVVGFLLPSMQHTENSIQDQFTFMFVFAIVGAAMMIFVRTNTIDRFFHGYQLTLCSKVVIQIPFRTSSTGPNLVEKRKITATMGPNDAFFLMSPASMSSISVLSPDMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W771</accession>
    <name>A0A6G0W771_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VLIG-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_018129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000320">
        <property type="protein sequence ID" value="KAF0722898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W771"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006587"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019004"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030383">
        <property type="entry name" value="G_VLIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22796">
        <property type="entry name" value="URG4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22796:SF1">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51717">
        <property type="entry name" value="G_VLIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VLIG-type G" evidence="1">
        <location>
            <begin position="954"/>
            <end position="1028"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0722898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1028" mass="115407" checksum="003E0E2DA2682101" modified="2020-08-12" version="1">MSTRLRGVACSYETFTCYHLLRLLIDNDEDTMVFQPTVVDSELFRFLRALSVLPKTDLESSTTTENSQSDLLGQFLNGQALPSSGRSMDVMGYFGRQFAVEQQLTTDGWWLQNLSDYIKNEEEGVYGLIQGSVDEDGGDLRVVLFGWLTNESFEGAFLRERATYVLRFLTTLTSNVVCCLAPQDIIRASPAPSSEASTLPKKYSVSFSIKTAKVEEEQVRCEFKYEAGWGDEFDNGELVPGPVVALAVIKSDRHVISERSSHYLTSVEAFGTWLIEIMKTHAVDVQCQIPRPMMASALKLKNEFPKDVLDSITEGVIRAQIRVDADLKVKKDLAMMQKRCEENGEIAFYVRIDDPQQENLANDALQKDLKMLKGWHMSVGSALQPALADFRSTIDITVNKAYEPIAAKNDIETKGILSGMWQWFTTANQISFPYLEKGELVKQALENSANELKNHYQSWCRLLNTAMKNEKIIAWRVDREYNAMMKAVNLKSMLSSRKEEVVRNSFAVMIDNHTKAELAGHLVTEVVNCYNHSVVFRKQEIKEDAEIVSVYCVSKTFPELRGSFTLPKKAKLVHISLVEDICVIVYLQERIANMETHVRAYKKSNWTKSIAAKHFPKETHLCDFDPSHRLLAMLHSDNLIDLYAFNESYKVLERVQTVNLQFLRVQSPFYSMVIFGGDNHGLALIDQEGRLQSSFIRSKQVSKLIEHLVIIGNTKLVKVQGESSYTVKVQTVLTADNTMLAEATLKIPVVMEWSRCSVSCVGENLICFDSVSTRVRIWNLHIATGKMAWQLQGSQTTKGESVPLEDHPMWSLFHLYEKFPVQSLVATSTGSSLVSGRLQIHVSGSANKAAVTNLLTLVMHKLQGLNKNLSPLNLEDDLKVHTSGSVSWCGSTVAMAPWVLELVVFVPVQICRARDNQLILLNNGHEENSMGTEAHEVAKSICFGPISSVLQHWGGPVVVLTSMGKQSTGKSYYLNHLTGSSFAISGARCTDGVWLTVRLMGKCLLVVLDLKAWDHLSVRLKRIYFCLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W853</accession>
    <name>A0A6G0W853_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_018288</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000327">
        <property type="protein sequence ID" value="KAF0722689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W853"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020740"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40866">
        <property type="entry name" value="BED-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40866:SF1">
        <property type="entry name" value="BED-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0722689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="164" mass="18854" checksum="368872B00A44E826" modified="2020-08-12" version="1">MQIPTSILRNLYGKSWPNVAALVGDNCLTNAAFARKAGVYFVGCASHRFNLFMMDYISQYEETIGRVNTLMKKLRQLSLAAKLRRLANLLPKTRQQTRWSLTYEMSERFMTLRDFLMQLGESEVDALLPSVTESRDLDRLLLELRDMNAVTLELQRDDLTVADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W8F0</accession>
    <name>A0A6G0W8F0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_018422</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000335">
        <property type="protein sequence ID" value="KAF0722419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W8F0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014911"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037176">
        <property type="entry name" value="Osmotin/thaumatin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001938">
        <property type="entry name" value="Thaumatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31737">
        <property type="entry name" value="PROTEIN TOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31737:SF2">
        <property type="entry name" value="PROTEIN TOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49870">
        <property type="entry name" value="Osmotin, thaumatin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51367">
        <property type="entry name" value="THAUMATIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0722419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="364" mass="37668" checksum="A62CFA890D193C71" modified="2020-08-12" version="1">MAYDHASPGVQDGNSIVAYRETDWVPRPTDLKDTEEYEQNFQMRRRNRILMIVAATFVVVGAAIGVIVATSSKGSTISTSSADITQAPTTTAAPVLSDTVSADVPSTSDPTTQTPQITYSVADVNSTSGDATNSTAKNGTSAGEVSVGSTGSSTESLSISETTTSAPTTVAPTPAPTPEPTTAAPTPAPTPPPTTTTPKPTPAPTPPPTTTGPLAPGYFRFVNNCRSSYSLWYSSLGGAKQVVKVLGPGDTFDTDGRLARSAMFFVSSSSDSLGDATLFETEFSSGTFYYDISIIPVGCGVSWDSCGGKHYAFNVPMSVIPSKTGGTCKNLVCGAPGCSDAYHVPNDPQTWTCPGSVSMVISFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W9A5</accession>
    <name>A0A6G0W9A5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_017361</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Host cell</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000295">
        <property type="protein sequence ID" value="KAF0723785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W9A5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012161"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043657">
        <property type="term" value="C:host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045379">
        <property type="entry name" value="Crinkler_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20147">
        <property type="entry name" value="Crinkler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="284"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0723785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="592" mass="67574" checksum="483C44E813E77F18" modified="2020-08-12" version="1">MVKLWCGVCGDADIFSVDIQLSQDVETLQVAIANKYKDVINRVPVLSGRLKLYFAGTKDGDKTMWLADDGNAETLLRGQIDKKYERMFSSCTLEKYFGAEFQPGREQIHVLVELPQISAGITSETPVTAQAQQISSIDDDDWTSEWLSEFRMSQIEPQDLPSLGKLAEFTESELQVKIPIQDRLRGQWLAKMDVPNPGLINKLFRIDNEKPCLTLVNDVIRRVVKPVKTDFVIDGLSDRDTSRGSSTGLNRPDFIFIVDSVCVFRGEEKAPGFPIENPKQELVTKLDWTYGKVPYLLGYAAVSYHIALCAITCEDDAVSATELGRYDLQSLEGRFQWLLAILNVARLFKSLACLCPDSARGEFRRINRNHGITIYFDHSSVFKLFPEELYQNAKHHVEAVYDVLERHKVPHVDSLVRKTTKENTLVFKPRGEERKPANLVELFQALVNVLEALVKLHAASWMHRDIRWPNVMKRLDANSWFLIDFMDAAKSPQNGSSDFHLTKEEHAPEIFQDNGHHTTAVDVWAVGLLIRKSRIDEWNDKGKERTKFLNDLMQEDPLKRPTAQEALAQLRQLEQAYNQPQCGKGKKRQRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W9J1</accession>
    <name>A0A6G0W9J1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_017228</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000289">
        <property type="protein sequence ID" value="KAF0723990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W9J1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017342"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0723990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="389" mass="44438" checksum="6298839CBFE53AAD" modified="2020-08-12" version="1">MGRNTMMKKLKVSAPAFSLLPVDVIVNIAFSIPIAADLFAFLEALRPYNLLGPLEHLYQLGKQLDLIQDLGQATWLKKHLGPQTKIEWIVNHFPTSTKEIADDVWDLHITRVSHGFKYNSLSSGKKILSRLKHLTTLKVYDEHAFSMPAEALDDYHQAWDDIFQFVEESHQLTELQASPDSHAMSSSNLVNLITWFRRQPVRWLKQSFYEAIFNCLTLDKLILRTCDFKGLDFSRFRFSMRSLQVGYCRGGSDYIYSLASRLENSNLTHLNIYVRHDVSIDSVKSLVRVLTTTIRVYLPGLCTPIKQLALKGLPFDSTDLSKLAPLFENCPLESLSLHAIRSSFSFVKSLATAIQNKTIHDLEVLFPVITVEEMRLLIQSVCHPSRRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W9Z4</accession>
    <name>A0A6G0W9Z4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_017709</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000309">
        <property type="protein sequence ID" value="KAF0723367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W9Z4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011614"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0723367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="211" mass="23044" checksum="EAE21FAEF6732E89" modified="2020-08-12" version="1">MDTAARAELPTLLFIKKLLHYLSLASSFCLVLLSVLGFQQLARNSLSSFEQVESTTSDGCLLFLGVTFGALLFLGEFKWELFFFFFGFLRYRFGRAIVYAVSGIMTILMGRTRSSCTECTSYSLLLAEGIALLAVSAFQLVAIAPFGNTTAPPAVERQTNSKTALTTLQRDVEREPTVAAPPPPPVFEAKTAPPESPASPKNPNMPSWMQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WAH1</accession>
    <name>A0A6G0WAH1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_017326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000293">
        <property type="protein sequence ID" value="KAF0723875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WAH1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006721"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0723875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="287" mass="33703" checksum="4FFDD4A539E63662" modified="2020-08-12" version="1">MLRDRRRRSEPRGRSPPHGRSCSELRLRSHHVDNLALGHQEDNLRHAEDLHEVAIIKKYERKNLIDWCKKHIKYESQVQGLGVEYDLPSRSYIHKWIDLIEPIMLTALCEYQWYCNHEDLTEGHFQRYILDVVETRPSKQKVTATDLKKALKHVTMKAKGDVNHRVMENVYDSITNHYLWQPLEETETRKVFVRAVTEIMPLELADQVRENYEVAQCDRTWMQRKELECPGTCKLKSEVKLTKDENYVCLGCAIHSQTLSCLDMQEGFPGLGLRWNDACLCATCTRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WAY2</accession>
    <name>A0A6G0WAY2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_017161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000285">
        <property type="protein sequence ID" value="KAF0724053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WAY2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003396"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33977">
        <property type="entry name" value="ZINC ION BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33977:SF1">
        <property type="entry name" value="ZINC ION BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MULE transposase" evidence="1">
        <location>
            <begin position="267"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0724053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="459" mass="51706" checksum="DDEB0CB136613291" modified="2020-08-12" version="1">MFNWNFERNGDTARRDVAANPTARDVGIEHEVVAVGENFEDESHNERSGVDSIEWTMLGAFSNLQMARDVVDFSSVHATRESKCMVCLTSATHKIKTRYLRCKCGVLCTKLVKIVHCLAAGNCVVYARGQNGDCAKRPSGHLTKVVKAEAEKLFVMGATPSQALGKLSKMVPEANMPKLKKLQNCYRYFRNQSMNENNSTSQMVSQLLRRRFQHGLAVNEAFTFGYEIINGQPSIGFGGTEDPFMVGITTKSLLSQLDRDPSSFLFHWDATYKLNVKAYPVLVCGISDLARNFHPIAFFILSKESETEYAWASDSLMELYAEVFGRRLKFTYVMADAGKAPTKAIETRSGLLGVVKLLMCFYHVIANVQNFITGMSPRTKALVYRNIYSMHYSRSADELEHHWQQARNVWTTNVELVSKIFVAISTRNGCEAVRGYGKCTMHRLVFPLRTTRVRLSTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WBH0</accession>
    <name>A0A6G0WBH0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_017561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000301">
        <property type="protein sequence ID" value="KAF0723594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WBH0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012642"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047655">
        <property type="entry name" value="Transpos_IS630-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033545">
        <property type="entry name" value="transpos_IS630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564:SF1">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="150"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0723594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="360" mass="42519" checksum="DF5C2F1C525F54AD" modified="2020-08-12" version="1">MEAAATRQHAHPNTVYNCLYGYYHLGYSKQILAHVYNKTERTIANWIRSYEQDREYRRHSRRQGRKFTTAQRTWLFHFYQDHPLAYLDEAQDAFQQKHGIAIPKTSVWQIVHDLGLTWKVLERRAMHVNERDICRFADELSHINWLRQNVVFLDEVAFDNRGKIRRRGYAIRGKKVAVRGDFQRKPRISILAFIGVGGVIDYFNTDGTFDRAEFTRCCQDFVYSTKASVQQYPGRNSVWIMDGATIHRHPEIVHYLRSVGVVPIFLPAYCPFFNPIEFLFGYMKKAFQRHYVEGSDPDLLPFIVQTFRLFERFSMGKVFEHCGWMRQGFFNHEGPLSRQVHSTSNLPHDELGFVELEHNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WBX1</accession>
    <name>A0A6G0WBX1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_016622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000264">
        <property type="protein sequence ID" value="KAF0724748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WBX1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003663"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0724748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="146" mass="17005" checksum="2C0788D7B084A10E" modified="2020-08-12" version="1">MIEMEGHLMLLAPGQGGHVHYFVLADGLLRMYTSRDRSEQLQSIPLTKHRVRVVAMDPPPTFQLSIYDGRGSSTQLVLLASSHLSMMRWMHCLAKWRRLGFAAPEMIDQCDENIETLHLLLKQRWMADEASFLQRNKSPFWLKRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WC38</accession>
    <name>A0A6G0WC38_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WRKY19-like zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_017331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000294">
        <property type="protein sequence ID" value="KAF0723836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WC38"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012476"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056866">
        <property type="entry name" value="Znf_WRKY19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827:SF1">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24906">
        <property type="entry name" value="Zf_WRKY19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WRKY19-like zinc finger" evidence="1">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0723836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="170" mass="18912" checksum="6F186E1CF3403E96" modified="2020-08-12" version="1">MPLVDLDIKVLLNPADEYEVEPIDPRLSLAFVCNTTRIEAFCSALFVESSKKCLDQHEALKSPRTCSFPNCSNKVKRDGVCWRHGGFRYCTIDGCANRLKARGLCWRHGGGKPCKTLNCSKTALRFGHCWAHGGGKRCQVDGCARPAYKRNDDKCDLHSAISQSSKIVMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WCC6</accession>
    <name>A0A6G0WCC6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrator complex subunit 5 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_016481</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000254">
        <property type="protein sequence ID" value="KAF0724921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WCC6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017082"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034472">
        <property type="term" value="P:snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040316">
        <property type="entry name" value="INTS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029444">
        <property type="entry name" value="INTS5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31697">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31697:SF2">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14838">
        <property type="entry name" value="INTS5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrator complex subunit 5 C-terminal" evidence="2">
        <location>
            <begin position="741"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0724921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="905" mass="101511" checksum="17E8679BC49D368E" modified="2020-08-12" version="1">MTFVASDTTVDDARTQFQLAIKKYFNVKTKSKKSRPKKQPRLENSPSPLLSQDLETISKCIVYLQQPLNYEPLQVETVVEVLRATLLCLEDLYEYAPLAGLLPKHPNENMEAGKQVNELIATAEKHPVYMVLLGVVRRCVNVACCSLGIDDCFPRSMHVLVEWTRESPDSAWLLAFTSKVAPQAVTAFSLRLLCEGELNPEDILLSNLDAYLAAMSPSKIATSIRAFLHETIASKTPHSIASLIEICSYSPRVVRACDSEFQNIFSSELVSSLIILGLQSNIDFQTKLSKLLRDQLEAMIEMPIHVIALMDRLLMDVPEVAECTTKYLSSLVKWIRNDESGLFSDRLLPALPYIQKKNPSSKVASQLVEAIAASVASNADRTQMACQALMILDDKDNISHSSFTSTVPSAAVCVDYLASELRVPNTTPLQNQKALSLLRNIVVQNLSQEHDAGNTAAECWKSLEAVNKACAVDQWPMLLNFADSSDQSVSLSALQLLIDIPYPLFEDPSWQYTCLHNLTSLFFSLLNKIADKNERTSQQLECVKRIFDRIMQEGGGVVSNPMSVESTFLSLFMDGILSASSPTTIPHDVPFEMNFFRGKSTKAGSSNSQVFRKLSATNCLLPYDPFPTKKLPVESSSQLDVFSQVQLIRSTQPPHALPAPSQFESKLYSVRVSEMETAINCSQHAEDLLYRSLRLGTFESSETSSVLMDILLERTIPVSVFVPSDDQYRDLLPERSNFDIDLRIEQWLYRYPIFLPLVKSAVLSSSPSVSVRCLPLLKSILVVLINHWHAQRFQPNTIQQEKNLHFPPYFQLSHQLQLSTEVMTILELSGWLPEPLNLCALLFPHVTALDVRTLLHSVWMYLADHPPNKKFSTKEPIAMENYLIPLQNVVHRNIQTIGPLYGYFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WD01</accession>
    <name>A0A6G0WD01_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">CBM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_016289</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in degradation of plant cell walls. Hydrolyzes the feruloyl-arabinose ester bond in arabinoxylans, and the feruloyl-galactose ester bond in pectin. Active against paranitrophenyl-acetate, methyl ferulate and wheat arabinoxylan.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the faeC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000248">
        <property type="protein sequence ID" value="KAF0725204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WD01"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019990"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043595">
        <property type="entry name" value="FaeB/C/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38050:SF1">
        <property type="entry name" value="FERULOYL ESTERASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026264882" description="CBM1 domain-containing protein" evidence="11">
        <location>
            <begin position="22"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="12">
        <location>
            <begin position="22"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="62"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0725204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="342" mass="36170" checksum="F9D9C6243E57854B" modified="2020-08-12" version="1">MKFAIASALVAVASVIELANAQGAAAWAQCGGQGFTGPTTCVQGYTCKVSNQWYSQCVPALRRPSPPPSHQPPARLLPAPPSPPSTGGSKSAGCGKPAGIASGTYSINVNGKNRQYILRVPQNYNPTTGYKFIFALHWLSGTMNDAASIEGGFYGLQALAKESAIFVAPDGLNRGWGNAGGEDVKLMDAIMDKIESNLCVDTTQRYATGFSFGAGMSYALACGRADKFRGVALYAGAQLSGCDGSSKPIAFWSTHGIYDSVLPIASGRALRDHFLQVNGCQAKNAPEPGYNEVHTKTVYTCKAGYPVWYYGHNGGHVADPKDPGQSFSWAPAEVWSFISQFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WDE1</accession>
    <name>A0A6G0WDE1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Myosin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_016743</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000266">
        <property type="protein sequence ID" value="KAF0724680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WDE1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001939"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010926">
        <property type="entry name" value="Myosin_TH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF845">
        <property type="entry name" value="MYOSIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06017">
        <property type="entry name" value="Myosin_TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51757">
        <property type="entry name" value="TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0518">Myosin</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="7">
        <location>
            <begin position="1"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="domain" description="TH1" evidence="8">
        <location>
            <begin position="906"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="6">
        <location>
            <begin position="574"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="99"/>
            <end position="106"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0724680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1092" mass="124054" checksum="5B20D3245A9AC0FD" modified="2020-08-12" version="1">MAVHDLVLLSDVDEEHVVEALVARYDEDAIYTFIGPVLVALNPYKRLERGQTGRSIYDDVDRFAGRTSHENEPHPFAIAESAYAHLLHFQTNECILISGESGSGKTETSKHVLQYLAAMSCSTTRHVKSKRASDHVVDAVHRVLEHANPVLEAFGNAQTIRNHNSSRFGKYMLLQMNWSGHVVGGFVHNYLLEQNRVVTQAAGESSFHCFYYLLAGAAAEDKAQWKVEHKGAAEFAFLHHENRSAIPGIEDPKEAYKELADHMLAVGIAAQDQRMVFQQLAAILHLGNVDFVAQVDENHNSSCAIKPASKASLDVAAELLGVSAASLEDLMTVKTLTINQTDMRVPLTAAQGVKMMQSLARWLYQSIFSWLVDTINRGIRTSQEASQTMGILDIYGFEILDENAFEQLCINYVNEKLQQLFIAQTLEAEQAEYAREGIAWLQIDYFNNQIVCDLIEDPKMPGMFPLLDEQCAISQTSVDVLMHRFHETYSSHAYFIKSRMKGSTFSVRHYAGTVEYDMRGFAEANMDSFVVELANVLQSSKHAFVQSLAQLETRSERDKLKRPPSTSTQFRNQVNALLQGLQACNPHYIRCIKPNEKKAPRLVEKDLITAQIRCLGLVENVGVRRAGFCYRETYAAFLHRYKILSASTWPAPKQCSLRQATVELLMADDIGVLPSLQPVGSSQTTMTPLKLYKAHLAAKKISNAAVDPSDAKILPFEQDKDSLGGFSLGQNKIFIKHPTALFSLERLRQDKLPQIAKIIEAAWQRRLVRLRLFKYLDVYNDVTARYEAVLLNIQQRLRRDTMAKEDSARLYASWHALADKVLPDTTRFHKRLALDEEFNRVSFATSFIKRNAAMRRLRLIKNAVKIVGSRWRGYHVRATMPPALLESCYQAMLGIRTEFEKLFGQKKRRRDTLDREYVGDYLGLVNHPHIEKFFTAANERQVLFAGHTIKVNERFVPQARLLLIGETFLHNIKAPRIDRPKERRLIPITDLAKLSLSPFHDNYLFIHVIHDGVGLMYNVHQKSEIALALRKRFRQICGRELLIEISDEISFEARRGRRLTFKFIKNPLTHATSMKKIDRHHGEILVGTKTPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WE32</accession>
    <name>A0A6G0WE32_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_016713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000266">
        <property type="protein sequence ID" value="KAF0724647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WE32"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009710"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031974">
        <property type="entry name" value="PDCD7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16021">
        <property type="entry name" value="PDCD7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0724647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="340" mass="38831" checksum="36F6C591F45C0E61" modified="2020-08-12" version="1">MANSPVPQNGQPWSRSQVPPRPLPPRPAPPLPYGMPPSPFLFNPYIPGVFQPPIDPDTAWLNEFASIHLAQTKHQEETSSLPTMREIRLTLFTALRRIRECRHLHEEMERFALMHQDTSVDPHVRTRSKLQFDRRNEILTRTWADLQEQYNDFFGDEAQLSRVKAMIRRIHRKKLYRRKAKKSTQAHRAVLHGLQAADSEAITTDSPEDIKVSTQSHHQHLQHLRSKLQLLIDLKAARGGANAQPIDKHVAEFIASHAPQPRREKSVDVPQVAQEKPTQANTLPLRDEDMTMDSLVAVRQAWDAFLTSKGGSRIPPHFVTPPQAPTSPWQQYVQEPNASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WE72</accession>
    <name>A0A6G0WE72_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_016194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000244">
        <property type="protein sequence ID" value="KAF0725297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WE72"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005884"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031397">
        <property type="term" value="P:negative regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030178">
        <property type="term" value="P:negative regulation of Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02964">
        <property type="entry name" value="TryX_like_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46472">
        <property type="entry name" value="NUCLEOREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46472:SF1">
        <property type="entry name" value="NUCLEOREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13905">
        <property type="entry name" value="Thioredoxin_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="157"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0725297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="429" mass="48082" checksum="0B0F761879CD21FD" modified="2020-08-12" version="1">MTSPFVELLGSTLVTKDAEKKEVSTETHLKGKVVGIYFSAHWCPPCRRFTPVLSKYYTMMQEKQTPFEIVFISWDNNQEEFDEYFGEMPWTAIPYASRDIQETLNKKYNVESIPTFILLDEFGQVINRNARKKVEKDPTGADFPYQPKTFAQLLGNNFLQGETGSATVDALANKHLGLYFSASWCGPCQNFTPLLAEAYESAKQAGHAFEIVFVSGDESKEDFEKYFKKMPWLALPFEVARAAYDDLSDKFGVDSIPHLVILGPDDSRPVITADAVGGVRKDKTDFPWLPKPVVDLSEGISASGFSINSKPSLIVFYETLAAEKQVEINGVLESLSVQAKTVCTGNVCTFVDEPSVIFFTNKEKESDMADQIHRFLGLAPPVNHPHAVLLDIPSRQYYLHQGGLEESDLRQLIGQFQANALTWKKLGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WES4</accession>
    <name>A0A6G0WES4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine/threonine protein phosphatase 2A regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_015744</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000231">
        <property type="protein sequence ID" value="KAF0725893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WES4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012333"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000331">
        <property type="entry name" value="Phosphoprotein phosphatase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002554">
        <property type="entry name" value="PP2A_B56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01603">
        <property type="entry name" value="B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0725893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="372" mass="43057" checksum="67EA31D74BC1EB99" modified="2020-08-12" version="1">MPQLLPDQVAICCQPENNDAKLERLRDLLEMINDPTFEYTEELVPRLMDVVTANVLRSLPDPPPSFEPDEDRPRLIPEWDHLEVVYELLYEILDASIPPRVIKQYITSTFCTQLLAILQSEDPRERVKVATTLHKIYAKFKSLRQHIRRSFIHILMQYVEYAPTGYPFGISELLEVLSSIIKGFATPLQSEHIELLTKTLLPLLKLSLRHYNQPLLLCMTSFVEKDPKLASVMLDYLVKCWPKQSTAKQILYLNAIEEILETAPVESLPNETKTKLTHVVAKCLESDHFQVAERTLFLWNSSQLINYSIFNPSHTRVVLPILFPSLMVAFKEHWNITVRMLAHSVLEMYTKHDNMTYQICLSQYKKAHATVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WFC6</accession>
    <name>A0A6G0WFC6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Clathrin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_015657</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasmic vesicle membrane</location>
            <topology evidence="1 8">Peripheral membrane protein</topology>
            <orientation evidence="1 8">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Membrane</location>
            <location evidence="8">Coated pit</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="8">Cytoplasmic face of coated pits and vesicles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TBCC family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the clathrin light chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000229">
        <property type="protein sequence ID" value="KAF0725992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WFC6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013878"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990075">
        <property type="term" value="C:periciliary membrane compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006599">
        <property type="entry name" value="CARP_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000996">
        <property type="entry name" value="Clathrin_L-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012945">
        <property type="entry name" value="Tubulin-bd_cofactor_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039093">
        <property type="entry name" value="XRP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15440:SF0">
        <property type="entry name" value="PROTEIN XRP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15440">
        <property type="entry name" value="XRP2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01086">
        <property type="entry name" value="Clathrin_lg_ch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07986">
        <property type="entry name" value="TBCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00673">
        <property type="entry name" value="CARP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0168">Coated pit</keyword>
    <keyword evidence="7 8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="10">
        <location>
            <begin position="13"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="229"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="287"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="359"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="257"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0725992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="440" mass="49117" checksum="5C0F666FC52A52EE" modified="2020-08-12" version="1">MPFTASDGTEFEDRDAWRQYEFETNFTFKNKKDETLTKFPGQIQGQPFDLADLENCQVFLLDHCDQVQIDNLVNCRVYVGPCSESVFVRNCQNCFFTIACKQLRTRDCSQIQVSLYSLTDPIIETSNNVLFSTFNAAYYGLRQQFTAANLEPENNHWTQVYDFNDPNKTGENWKLSHDAVEPFIIPLEQMIENAEALGRLENPVPANAQPIAADGGSLQSFSLDTTQEAATAAVYASEEPSSQSPPPEDEFVPAPQADSSFYEESNSGFASEPVSVPSVAETPVFAAETPPPVDIPPVPAASSSVPPPAPQSWPAMDEFESKLAAEVEQRRVEESTMIDQVKSQATLDLEKYYKERADKLAHRASSNREAEEEKKKTQELLENAESPWHRVTDLVDTTVAPPKSKTDSTTDKKDSNSDLYDTSRMRSLLLHLKNSGQATH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WGL7</accession>
    <name>A0A6G0WGL7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_015398</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000219">
        <property type="protein sequence ID" value="KAF0726283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WGL7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004239"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021544"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="492"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0726283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="727" mass="79975" checksum="D406EBF206F4F5B6" modified="2020-08-12" version="1">MSAAAASTSTQEMDNQQLPPGPTGQVTTNASSSTDSGPGRTFADTLRQKAATTPSKITLRIPLPNADRVQELLDYESQPDCDVEKLAEMMLDANTYAKIVSVGSVWFDTGSDLAQRTQNSQEWAPWLPCITRTRKARNGQLILSVSTIEAKSAISDLSLKLFCKTYKVSQPAVKRRAEVLDKYFYLDIAGVDADFDFKSATKGFFLWKLRPLVHLFTNVVPDTTFSFSSNVLRFYFCSETTPANLSVNSNLANHIQLDGKAYAIFPKGHTASVNTNGRQPVHCLNLDDVLQPAEVEEGQTPHKRQCVVLGEEDGKPDVQAQQKQQNNFEDPKKTAKRKEAPKPTAHSNGMSNNMYEVLRDINIVWTRLHNSGGDPLPTFVPDVTPLPKASYDSSSSIQKTSFNPTTKSLEWHPDAMSMEAIVQTLASVNTDSSVRKINAEEISLPDVEAVSVEISPLLQSAAADTIWTKIAANPLGMASYLIDLHGSGSPLFAQLARLHAGHRWFRLLYNNTSTQLIINGSLGKTIYPNRGVKQGDPLSSLLFVLSIEPLAQHLRDNSHLGLSFDNLNPPRALASLLFADDCTLLSPSKRAIDDQLELVQLYCDASGARLNLGIVFGHRLPASYQIQAISNKFFAAFPVWRFQARTLQGRKLITQTKILSTLWHYTAVLPVSTETVKSWQAMVTKFILSSKTLQSDKHMASVNPGLQFDKVSGLGIPTSNLLLPDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WH95</accession>
    <name>A0A6G0WH95_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_015165</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000213">
        <property type="protein sequence ID" value="KAF0726537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WH95"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020917"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF11">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="64"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="128"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="162"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0726537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="216" mass="23189" checksum="BAA69647D9B50531" modified="2020-08-12" version="1">MASLGIAARKGDLDEVKKLINSGYNPNAVDEDERTALHWAASSGHMDTVEFLAEISNIDHQDDSGWTALMSAASSGHVDVVSHLLSIGANANLANKNGQIALHYHKGRLEIAELLVDATRDINHADRSGATPLTKALGGRPAPDVIQLLLEHEAKLNTKDVNGNTPLHIALLEGHESIAMMLIEHGADPRAVNKDKQSCLDIASRSFQQKIAAKAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJG0</accession>
    <name>A0A6G0WJG0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C5orf34-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_014641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000198">
        <property type="protein sequence ID" value="KAF0727383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJG0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017218"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053901">
        <property type="entry name" value="C5orf34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027865">
        <property type="entry name" value="C5orf34-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34531:SF1">
        <property type="entry name" value="CHROMOSOME 5 OPEN READING FRAME 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34531">
        <property type="entry name" value="ZGC:153352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15016">
        <property type="entry name" value="C5orf34_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C5orf34-like C-terminal" evidence="1">
        <location>
            <begin position="389"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0727383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="544" mass="61349" checksum="660359C0209AE013" modified="2020-08-12" version="1">MEFHPSRLLLLRDGRTIGGFQLAGGTSKAQLRHTACLVVETNGSCFSYFTTQTMATSTAVQRFSCASCPSIHVPLLRQVLEFRNKHALSHGLYLHQHHLLPSKLQWRSGVRPSLHEPIVLRWQCGTYSVSRMDTEDGLRIKSLDGTASVTLSKTGHHFQALFLVPVESHVSETTARTDRYLVTRVEQVFFCENIPKAFEFPCQVLLAVQDARRNGQTLIDMSAVAPTSSYISTFLPLNHAFFARPKWTSFVNSKEALSEVDIFQLCRLPSKPATTLMVPLAVEWTPAATFHILQRRDSSVVVHAQVHADLSSISLVNGIYHHQRGDKDHCYTKMSVPPRPPFQDNQAYDLVDICLNMERLSENLLTTLSSSSTQMLNTQMAVPPNQVLEDHTTNIGRFRAFGDGRVRIVFSDRTILSIDRDARFCSLFLPSGTTETLSVMNPRPEHERYIMAALSFQQWAFRSPGERAEYMARLKRQQETVEVELRKTTTFMADIPVVSPGNIDSVQGILDATSAHIHQVQQTLLRHGKLENDSSNYDPPIKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJN4</accession>
    <name>A0A6G0WJN4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_014477</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000194">
        <property type="protein sequence ID" value="KAF0727455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJN4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021639"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021640"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF291">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="371"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="551"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="724"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0727455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="774" mass="87397" checksum="B774C6943BA1C124" modified="2020-08-12" version="1">MKTIDTSKKMKIFTGSWNVGNKMPPTNREGISAWIPEGGGVYDILAIGVQESTYKKKASHSNGNHEMETVPEQEHEEDDDDDDAAQDIEMQEVVLEEPPKPKTPTRMLSLTKHNSATASTYPFFVQLQEHLGSHYHMAGSVELMEIRLVVFVHTQHHVSDVEKITEATGVGNVIGNKGGVVLKLHVNTRSFCFVNCHLAAHEAQKFLERRNNDVAEILNGARLGQKSIELDHQFDHAFWFGDMNYRVNLGYSDPKEMSKEEHWAAVHSLVAAKEYNKLYENDQLQHQMHANKVLAGWTTSPCNFPPTFKRLRGKTDEYTKQRVPSYCDRVLWKSLPGFEKHLKLIEYKCVQDICTSDHKPIFASFELEPLPPASPDFNNHDMVEVKLTNLSAANLAAMDMNGQSDPYIKFYCSVPGMLLSDETKRPQTAVLKSTLNPSWDDIQIPALQLKCPLSQLQNVHLIMLLMDWDATSADDPLGQAVLYLPDYYAPEQSLPFEVPVIRNGIHSGTIRGQVSVAPSGKKFAEWEKNHTREAIRKEAILVQDVQRRLQAPPPISQRSTNDSFAADSSSQPSTASEEQAKLDELRGSWTTYINASEDKSLQSLSVANLGMLKLLQSPTLSEDELNGISDLLQELLVHRRTSIVAVRGEVQELDELHSQMIRLLHEKRCSAVAVAYTNFQLCHLQRQFRRLTTPYMRIIGIANVELPLLFEQARGFMDKVKSLTPSDTSMRSRRRKKLKLPDPPMDESHLVREKIHLWRKICLVVGAICIPSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WKX2</accession>
    <name>A0A6G0WKX2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_014136</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Folate-biopterin transporter (TC 2.A.71) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000185">
        <property type="protein sequence ID" value="KAF0727908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WKX2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017978"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039309">
        <property type="entry name" value="BT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585">
        <property type="entry name" value="FOLATE-BIOPTERIN TRANSPORTER 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585:SF5">
        <property type="entry name" value="RNA-BINDING S4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03092">
        <property type="entry name" value="BT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="378"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="421"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0727908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="454" mass="50414" checksum="6FB603B87F4ABDAF" modified="2020-08-12" version="1">MASKAPVPGQPKIWLLPPNETEQSIQLSGTTDVSTGNDYCAMLEASKCTKTADLPTEDEHGSGALRPGGALNLFSTEAFGLLSQYASGSSSACSTRYQSQSYKVLISLGWASKIFFGILTDCLPIFGCKRRPYMVLGWAICGLCCLIMAITKFPDPYYGKPGLRGLNNLTAEQLKYINDDAPTSADLFIVLSMIASLGFVMANVAADAMVVQYAQREPIAIHGRIQTAIYFTRDTFMMVPMLVVGFCMNDYKYGGPFSWRIGPNALYAGLTIPCLVGVYAAFALIVEEKAVSMTFRQYLHDLWELLQLRVVWQICAFKFFNLIFGSYISTLADPISSIWVHVQPLVATSFAIVAQFVRVVVMFIIGKYALSWDWRITMAISTVILVVMDTFIRTVAIWDVYRNQYFQNVRIALESIPNAFIFLFGTYVIVEIVQIGNEGTVYALVGSISTWRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WN97</accession>
    <name>A0A6G0WN97_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Myb/SANT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_013379</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000172">
        <property type="protein sequence ID" value="KAF0728807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WN97"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006239"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0728807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="26225" checksum="9EF802B0D539315C" modified="2020-08-12" version="1">MIDKSSASWSDELEIELIVAYKQAIRNPRFVCSGGKNLRSAGWSKVLEDLKGQGAIENAGQLQSKWRRLKTEWLDYNYLVQLSGFGDGFSDEKWEELDRGPRKLKLSRFRDKPFVHYDAMSNIIGDSMATGEDITSEDDILQSKSGSNALNVGDLDDAAKRAKILYNLKKNRKRKQDDSLAKSQSTRDKHIASMNWNLRMLTTLYAAKNGLTDLLQAEPQGSPNDSGDESKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WNI7</accession>
    <name>A0A6G0WNI7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_013452</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000172">
        <property type="protein sequence ID" value="KAF0728883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WNI7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016438"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000057">
        <property type="entry name" value="Cyclin N-terminal domain containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="64"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="245"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0728883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="284" mass="31390" checksum="81107E905B1B8C6C" modified="2020-08-12" version="1">MDLLACHEVLTPASVHTQETFYADVDDILANLYVRERRNMPLSDYVVRVQTHGMKRSWRSQVYDWLVSIANTADFEPLTVALAINYLDRYLSVVSIKQSELELLALVCMLCASKFNEKDCLSVAEVGQMVDSKYTASQVAAVERALMKTLGWNLHVITPQHFLDSWIALMDPSSAAEVSVLCAKMLPKVSRDVTSLKFAPSEIAYSVLSLALQQLQLSACTPTYAGTSDRLVECEEIVEVIMQGKASNGAQRPKPSKRAASPTNVEDFDAATSPARQRPRPASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WNK8</accession>
    <name>A0A6G0WNK8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_013251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000170">
        <property type="protein sequence ID" value="KAF0728948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WNK8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019432"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0728948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="262" mass="30311" checksum="3AEC9ED1870B98DB" modified="2020-08-12" version="1">MWTVPLAAWPSSEERRGRLVLNRCPHCNGEYGSASLSIHVARCRAKNEIITAVIDAIKPKQVPTLASMCIKFILGNMQVSCINGLYAQPMHQTWLIASLPEEVLQQVMMHIVHRHQVISAKHQSHKLQLKQLKDRIVSLEHLADENRILRRHRERVDQVIAHKNSQDEHRVKEMNAVRTQLLATNAAIQKAVEEIHRLKRTHETDQLTIKSLRNRLNDPTRHRIVPPRKVEKPEKVERPEKAERPEKAERPERTTKTFVAPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WPG8</accession>
    <name>A0A6G0WPG8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_013041</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000166">
        <property type="protein sequence ID" value="KAF0729295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WPG8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014964"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22538">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22538:SF1">
        <property type="entry name" value="VWFD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0729295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="535" mass="57874" checksum="12DE8F74E1EA401D" modified="2020-08-12" version="1">MRLSAVEGLVCMRLVLEIALFFAVYATGMSVEANISERHPSVPVLAQLKGAPAIRLTFHAKRAAMTFNGQLTAQVTVIPRSSNASAFEFDAILTQVGPEHTEEFMWLDNGAYWSKIQDDKVVQAGCIQEDQLPPLHLVASSISQAQIVHGLVNDNIDCPLDGSLLELSFASELYVVCTTSSHRFSHAKGAFLDVDIEYLSQDDHVPAIQAPQSPNGDILSCPSIRWPSQPLVKDANLATERRRRLSTATQAASCGCKMERKPCLFMDGVGHRESIPLQSSYPKTWGNIENHAPCCSSTTFARFETVTRDWNNPSLQADFCNAALSVSGSSSTTIGKLILVTHSMGNLIAAAAAASGVCHFTSDLTWVTLSGPMTGSQAANLLETECAKNDTQWFSKLAGPALELFGYCPVQPAYASLKYITTVDSSLQQKYAAAQAIRRQFVSRVLCGVSPGGLISVGSVGMQAVAALAPFDTKDNDGLVTFSSCTAGINVDFGTDAETAINYRATLNHLDTSFRNGDGWWSKDKMPSRWFECTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WR83</accession>
    <name>A0A6G0WR83_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_012566</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000159">
        <property type="protein sequence ID" value="KAF0729927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WR83"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002615"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF214">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="44"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0729927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="337" mass="37095" checksum="885C491BD3EAD267" modified="2020-08-12" version="1">MGCSESKQVQARQVSSPSKKDSHTAATTDDIKVNWALYRALKQYRDNYFIGPDDVKAVTVLVSSNDMTTEVGFLNGQFVYLKSVASSADDQATARWSLMTEISSRASIHHPNIVGFKGFTIAPTKGLSCVTEYMEGGTLRSLLDDQQAFAKLTWAVEKINFAIDICTALCCLHKDNPQLIDSNIQASKVLLNRDHTCAKLSGSQTFRGRRDERLFIGYAGEFGWTAPEALLGDDVDSKGDVYSFGVLLTELDTGLLLYAGIRDTTPLPLLMNKLVSKQLRLTLSPGCPEEIAKIVNLCIGHDPHIRPSSDRVLEMLQNAKIQLNSLTKESVVEFCPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WRI4</accession>
    <name>A0A6G0WRI4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CBM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_012447</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000157">
        <property type="protein sequence ID" value="KAF0730049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WRI4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004847"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026021110" description="CBM1 domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="4">
        <location>
            <begin position="255"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="4">
        <location>
            <begin position="297"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="165"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="177"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0730049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="335" mass="35470" checksum="DFB9878987AC55E9" modified="2020-08-12" version="1">MFNPIVYLALFSQVALAVNRDWPVFCTTLDSSSKLATIYENAISEDFAFTTSEFKSLRALMASRASICATSSVVHVDYVDEAIQNGRVSYQGACELWCDDARILHDDKCTIDFDSTDLGIDSSKCQSAKQLSLYTPTQETPSWQLCVTCNAAKSSQHVLYISEEFPTSEPSSDPFETTASTDSPPDSYPSISTSTPSPTSSPSDSYPRNSTSAPSPSNSTLAPSTITAPPTAPPASPAPSNSASTPAPLKTPSSGVAKPYGQCGGIGFTGATACPSGFVCSKKSDYFSLCDLGAQSGNVPIWGQCGGKLFTGSTQCDPNAQCKVVNDYYSQCIHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WSF5</accession>
    <name>A0A6G0WSF5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_012115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000154">
        <property type="protein sequence ID" value="KAF0730413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WSF5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006267"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19076">
        <property type="entry name" value="AKR_AKR13A_13D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF40">
        <property type="entry name" value="ALDO-KETO REDUCTASE YAKC [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="25"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0730413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="401" mass="44042" checksum="D04B9C512A02F627" modified="2020-08-12" version="1">MVQVPQRPLCSQGLVCSAQGLGCMGMTAFYGNFDRAAQEEESLRTISKALELGINMLDTAWIYQSFGAGGGGNFTNEELVGKAIKQHGREKFVIATKFGLVPSAEGFKISGMEEVLRSQLADSLQRLGTDYIDLYYMHRMDPETPIEDTMRVLKSLVEEGKIKYIGLSECTPSELRRAHAIHPVTAIQMEWSLQSRDLEAAVVPVARELGVGIVAYSPMCRGFLTSIDTFDKLEENDFRRNLPRYSSNTLEQSKAKVARFFEIAKEKKCTPAQLALAWVHAQGPDVFPIPGTKSSTRIVENAEAVDIHLTPESGCGSSGRERCLGSREDCCLKSAEKMTFSKAVASTFEAATAAKSAAPEMAQSIRGVVMSITVGQDALPSWIRHGFYKTRQLLSSWCDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WT42</accession>
    <name>A0A6G0WT42_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">A to I editase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_012014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000153">
        <property type="protein sequence ID" value="KAF0730595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WT42"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002356"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003726">
        <property type="term" value="F:double-stranded RNA adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008251">
        <property type="term" value="F:tRNA-specific adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006382">
        <property type="term" value="P:adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002466">
        <property type="entry name" value="A_deamin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10910:SF62">
        <property type="entry name" value="AT07585P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10910">
        <property type="entry name" value="EUKARYOTE SPECIFIC DSRNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02137">
        <property type="entry name" value="A_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00552">
        <property type="entry name" value="ADEAMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50141">
        <property type="entry name" value="A_DEAMIN_EDITASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A to I editase" evidence="1">
        <location>
            <begin position="50"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0730595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="371" mass="41089" checksum="AFAA86BBA4379B62" modified="2020-08-12" version="1">MPPACVPDAVAAAALTWFAQRVAGKKHAPNEYTVLSVLVVEQDGEWTVVSGGTGTKCVGLSGLCREGYILADSHAETMCRRAFLRYLYRELDAPTADVPPIFDIVDGKRRLKSTCRMYMYISEAPCGDAALYDLHQDALDEIHESKLKRRKLDQETVTTVPCRTTGAKEAETIEHSNALGLARVKSGRSDILPENRTVSMSCSDKICKWLACGLQGNLLSQWFEPIILSGIVVSQDSKADDGSFHRALQRSVSRSRVDSCTVWSTKLEFPLRRSETRASASGMSLNWCLGCDNVEYTLGARGVKMGAKKKLDDATKRKMCSRLCRRELSQLALKHQDDAEDANTKTGAMHSLLCRPFKRGRAFLQNTMTLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WT52</accession>
    <name>A0A6G0WT52_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Solute carrier family 40 member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_012024</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in iron transport and iron homeostasis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000153">
        <property type="protein sequence ID" value="KAF0730605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WT52"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009638"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005381">
        <property type="term" value="F:iron ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009716">
        <property type="entry name" value="Ferroportin-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11660">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 40 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11660:SF57">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 40 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06963">
        <property type="entry name" value="FPN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="470"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="492"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0730605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="520" mass="57485" checksum="71F871838579E8C5" modified="2020-08-12" version="1">MELDRSSSTSLVLGGVCLLVGAIGLFRDEIAAPFKTILVFSGFTSLVPIVTCIIAFLLDTKLKREEKTPLLTYSHLETASISCSGPTCRAEGPSRLAKHRLHVYLYLTHFLTTWGDRMWQYAIPVLLTQLFPSTLLPNVVFQLVVYLVLVVSMPYVGQFVDTTNRWIVIRTGIFGMNSMVWISTGGFGGAVYFIEDDVMPIVCIALVLLASAVGQIFSDMQTLSLEKDWVVELAAATNSPLSTWNTMLLRIDLVTRLVSPMVFTFFLDKTSSMTPHEAFWLLVGVAIWNTLLCPLAYALATDVYALCPSLAGPKRKGAISYAAMWSTYVRHPTFGVSFSFCALYMTVLKANALSSTYLLWHGTSASTVGYNMAVAAFSGLASTFTYSLLLQWSRESAKLVVISVWIYSACIVPAGVLWIWPQDARTNFVLLAVLSGSQFWLWTTTLAEVQVMQEWVEPEHRGLVNAMQHTVNKGFFIALLLFGIMWPHPADFGNLVAVSVLATVLAALGFTVWYAKRVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WTV6</accession>
    <name>A0A6G0WTV6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_011762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000149">
        <property type="protein sequence ID" value="KAF0730880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WTV6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012831"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0730880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="380" mass="45010" checksum="D52506C0E37CE763" modified="2020-08-12" version="1">MAKPDEVRRHRATARCTRWSVIHNVIFFLNLASTPFMAYLTEPRPGEVKVNFMPPWNTFDEFVNVTTAFFSQIYNNHTMDENKVSRRDTDYNMFGIRSDLTIPYEVNGDKVFDILVKMPATLFYGYGVRDYATRFITSNKTIRNQMRPWQICQHEYYMGMTWVEYCLWIEERGVNQYTAWGVSYINEGHGRMWLKFAYRCVLSLYVMRILWKHYYVHYIVLLSNLREFGIASKYTRYDIVVGDPAYSILSDPFMSFAMVVDIWWNIDYISLALMRVTQFQDFWLYMWGCMYLSRYVWFAYLGLRIMSFVVRWRRWESSFAPLDPGLLAITAYIYGGPVISILGTTQALRIFSLLWSFFLPKAESNQAIEAITGRVLIDNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WW37</accession>
    <name>A0A6G0WW37_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_011004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000140">
        <property type="protein sequence ID" value="KAF0731700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WW37"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003550"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="148"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0731700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="225" mass="25603" checksum="9CA15409D349FA41" modified="2020-08-12" version="1">MDTTDPRAVVPAGFAREYELLADEAPKDDKFKIATQSLYVCECGKHIANANEYNIARHKSSKRHAEALTNSDSEFFLCECGKRLLRSQKENEDNMAQHRASRKHIQAMAKKQKLVHPQADLSFYSRPDDTASVWTSTIQSVRSHVVSLDLIKEAEDELMRGLASLEQEYQRTSALLTMLEKAQQKAHQRAEKLQSENLTMKASVVTILQNRDQELKLLKNIADMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WZE7</accession>
    <name>A0A6G0WZE7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SF4 helicase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_010075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000127">
        <property type="protein sequence ID" value="KAF0732970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WZE7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021711"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01029">
        <property type="entry name" value="TOPRIM_primases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01122">
        <property type="entry name" value="Twinkle_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.580.10">
        <property type="entry name" value="Zinc finger, CHC2-type domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007694">
        <property type="entry name" value="DNA_helicase_DnaB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036977">
        <property type="entry name" value="DNA_primase_Znf_CHC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034154">
        <property type="entry name" value="TOPRIM_DnaG/twinkle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027032">
        <property type="entry name" value="Twinkle-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12873">
        <property type="entry name" value="T7-LIKE MITOCHONDRIAL DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12873:SF0">
        <property type="entry name" value="TWINKLE MTDNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13481">
        <property type="entry name" value="AAA_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13155">
        <property type="entry name" value="Toprim_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56731">
        <property type="entry name" value="DNA primase core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51199">
        <property type="entry name" value="SF4_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SF4 helicase" evidence="2">
        <location>
            <begin position="408"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="712"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="723"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0732970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="772" mass="85777" checksum="5758D357C4E96793" modified="2020-08-12" version="1">MRRLVQGKLFLRSRPVAASLARWPSMGFHASAMRSASSVNANPKAFVSKYYELGDHRTIDEFLERKGLVVKETSTQYIVRDCPFCHATKGRADNLFKLYINKANGVYFCHRCGASGSWFAFKQKLGGGSEVVEASMGYADSAPRYDAPKVISVLDNAKAVALTRNLHDDEECRHVLDYLTATRGLKPEVLSKYCVGAIQQPFHSSTDNSMEDKWCVTFPWMARESDISLMGVELTEPSVSSDANLFNVIRLKVRAIDDKSKQRLVPKGGSWGLFGWNTVPANADSIVITEGEFDAMAVYQATGRPAISLPNGCRSLPPAILPLLERFSSIYLWMDSDVHGQDSIDKFSAKLGVARTYIVRSSAKDANDALLAKMDLNAILDDARIKPHAQIATFEEMRRDVLDEMMNPLRASGVQSRSLPALNSYLKGFRNGELTVLTGPTGCGKTTLLSQLSLDWCAQGISTLWGSFEIKNTRLMHKMLTQMAGRSLACNMELFERTANDFELLPMYFLRFFGSTDVDEVLDAMEYAVYAHDVQHVILDNVQFMMSGQGRGYDKFERQDAALDKFRKFATAKNVHITLVVHPRKEQDDVDLTISSVFGTAKATQEADNVLILQRIKGDVKLDVRKNRFDGSLGSIPLVFDKEAICLRERFPSHMDESLATRDLELQMQREARHNAASISPSTAASSISSSTSVEFFAPQMPQINQVHTSLEEPSKVNGHQQLNGHALNGHNLNGHATLNGHKVNGHPVNGQKVNGHHEPEPFSLFTPIVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X263</accession>
    <name>A0A6G0X263_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_009468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000119">
        <property type="protein sequence ID" value="KAF0733911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X263"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001706"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0733911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="22376" checksum="44418401BD24BE84" modified="2020-08-12" version="1">MLRFLNSPVTVIALRVAACGLATFVGAFLMANHRYPCSRREIFRYQLRTEDTLLTAMALTVAMLTPMWVCLHAWGKVKWIASLNYLFEIVSIVLILVPMIYWGTSATATTACGTLKDQTGSLCLSNVCDVIQVSMTTSSVLLVVLLISFFIAFFQTRKASTPTMLDKCVVNETMMEVCTPRDTFHTELVTPTTVSEATEPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X2H2</accession>
    <name>A0A6G0X2H2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA 4-demethylwyosine synthase (AdoMet-dependent)</fullName>
            <ecNumber evidence="4">4.1.3.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Ae201684_009204</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:36347"/>
            <dbReference type="Rhea" id="RHEA-COMP:10164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10165"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64315"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="EC" id="4.1.3.44"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">tRNA modification; wybutosine-tRNA(Phe) biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TYW1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.44" evidence="4"/>
    <dbReference type="EMBL" id="VJMJ01000118">
        <property type="protein sequence ID" value="KAF0734031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X2H2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009587"/>
    <dbReference type="UniPathway" id="UPA00375"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102521">
        <property type="term" value="F:tRNA-4-demethylwyosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031591">
        <property type="term" value="P:wybutosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000196">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013917">
        <property type="entry name" value="tRNA_wybutosine-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034556">
        <property type="entry name" value="tRNA_wybutosine-synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13930">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT TRNA 4-DEMETHYLWYOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13930:SF0">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT TRNA 4-DEMETHYLWYOSINE SYNTHASE TYW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08608">
        <property type="entry name" value="Wyosine_form"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00284">
        <property type="entry name" value="tRNA_wybutosine-synthesizing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01071">
        <property type="entry name" value="tRNA_wybutosine-synthesizing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="16">
        <location>
            <begin position="68"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="17">
        <location>
            <begin position="357"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="241"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF0734031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="697" mass="78430" checksum="BB0CC66E152DECBA" modified="2020-08-12" version="1">MLVIQPVQAAALAAGLAIVSASIAYVLWKSEQEKAKSVSLQAKSASCCSGSSSTCCQTNEQTVKPVAVRILYGTHTGTAKGFASALEKKLFALNVAGYAFEPSVVDMKDYDQDNLEHEQVVIAILSTWTGGVPPESALVFCNWLQDMALDFRVSKTWLKHVHVGVYGLGNSEYDENYAKASKALSKHFSTLGATRLLPRGVGDDNQDQTAQFDQWSDNLVAALCEQYANLRQPSSAAKEFLSTKEFRRQKRKEKAKDNEDSDNLTEEDRMNEIVLEDDEDEQPKAKGDGVMDVEDIGVAMKESEAAALSREMVTPLQRKALTKEGYKIIGTHSAVKLCRWTKHQLRGRGGCYKHTFYGITSYQCMETTPSLACANKCVFCWRHHKNPVGREWRWKTDEPKELVEGAISRHQNMINEVKGLPGLIQSRWEEAFTVRHCALSLVGEPIMYPHINEFCRELHARQISSFLVTNAQFPEKIAALEPITQLYVSVDAATKDSLKAIDRPLFKDFWERFLSCLEQLKAKGQRTVYRMTLVKEHNMKEIDNYVELIQIGQPDLIEVKAVTYCGKSDASDLTIKHVPYHQEVREFCELLCSKLGGQYDLATEHAHSNCVLLAKTTFKIDGQWHTWIDYDKFHALIQKYYADGTPFTTMDYIAPTPAWAVYNAPEAGFDPVEQRFRRTKEGKVVEIEYTATDSGCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X3C5</accession>
    <name>A0A6G0X3C5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Retroviral polymerase SH3-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_008875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000114">
        <property type="protein sequence ID" value="KAF0734415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X3C5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020583"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retroviral polymerase SH3-like" evidence="2">
        <location>
            <begin position="2"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0734415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="266" mass="29020" checksum="26D2CDBF480A024C" modified="2020-08-12" version="1">MYIGHEPGVKGHRLYCAKPEKIVISRNVVFNETTCFFIDEPLPSVADLDPSIDNSTPPVQVQSTSDPTPDTLPPLRRSSRTKRLPSRFNDSSDLANSNGTSRGTSTTPTRDPSRTSSVTDSTSLPSATQPTESEHFNREQPSHPTPAPPMVTPTQTPAASAVPSNATAPRVPQQPEHTPVHVDNVQPEYIPVFDEPTISILDPDASRPPPLPDSPPPSPLSTGVRLTKEEWEALAAQEHRILMAYLVLDFQPPFVKLMLPMNVMDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X3D0</accession>
    <name>A0A6G0X3D0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_008954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000115">
        <property type="protein sequence ID" value="KAF0734352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X3D0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010154"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037646">
        <property type="entry name" value="PROSER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22045">
        <property type="entry name" value="PROLINE AND SERINE-RICH PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22045:SF6">
        <property type="entry name" value="PROLINE AND SERINE-RICH PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="515"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0734352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="602" mass="66592" checksum="173DC517A4A88745" modified="2020-08-12" version="1">MERTSTIATYIRRFRGPPTSREERERAREEREKDFWWVDKASQSEKPQRSEVHELQQSRDVDALSNDVYYDEDLDSMHSQMSRSTHDQAMSMDELATASPPSSRLAVPPPPPSPQPHRDTINEALEENVLPRRSPDFDESTLDVIAGLPSPAHSSIESLLHSDAGQMTSMSTYRSFDGPLNQEKAPSLSINSSIESSWYASRPEDVLVEDPEVTIQRLRSRLGLPSLWTEDTLNSHLSDSPFSPSIEPLSFAPPMQHCFYGGDVMSVSPSSFDLTRERRLSAFQLDVPSVAMSPTSACPSDNVNLGEAHEFVAKSTEECLFECQPENLESSKTKRVSVENESADSDGVDAFNPSNQQTDTATTGESLPEEESRQVSRPESTAEIPVETADTSNEKKEDASTEHKKSIGIAFRNRNHLPLPPIHPEVKDKESPDQVTSTFDEMEAIDAPAEMYQVYDAVQTSSDDLVANAPDSNGAIKDIAKVTSSSEAEEIAVGDIVDNLVTSVVLSWADEAKTPVVNSEPQSEERGDLNEPEVCGKQVEKTKLLDPQPSVALASEDLAQDTLLEEEDFSYLDDDIARMLVQRILLCEEALAILNARKVLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X3H0</accession>
    <name>A0A6G0X3H0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_008846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000114">
        <property type="protein sequence ID" value="KAF0734386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X3H0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007290"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0734386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="115" mass="13331" checksum="1769D592825FCCEF" modified="2020-08-12" version="1">MKGSPQEMGAIDGQDERKNYYELNRERILAQQKAYRERKRLRLLQATDGILIEPKRRHPRVKHIKLEQSVKNDENSGNKGQDATDSAIEMSPHNCLEAWKLAFESSHVVSMFPIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X3L0</accession>
    <name>A0A6G0X3L0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_008765</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000111">
        <property type="protein sequence ID" value="KAF0734520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X3L0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010674"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF9">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="58"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="91"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0734520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="165" mass="18584" checksum="8AB9CD61A3582079" modified="2020-08-12" version="1">MATQLKPMRYGKPQAVDPEEVARRTEINYALVEGAAKNDLVKVEEALKNRADIDCRYQGFTALYFACMKGYSKVVQYLLHHGARTDVVCNKQRTAIMIAASRGRTKAVELLLEYNANVHRKDERGVTARELALRNGHEDIASMLQIAEAANMPRTELLLHRLAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X4K1</accession>
    <name>A0A6G0X4K1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Condensation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_008608</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000106">
        <property type="protein sequence ID" value="KAF0734757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X4K1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001467"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0734757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="387" mass="42331" checksum="E37564F0DE5BE524" modified="2020-08-12" version="1">MQRLKLLDVEWTTAICPPISTVTFYSTTDAPHSSTKAYIQQRVDAIVQANPWLAGRLTSGLFLSNITLEFNHTPSAVIVEEAHLPNFSNQLDYSQIAAMCMPFNVVSGATMINSNHPMVRVTWITISDTQGALFFSVAHGIADGYTYYRLYGMLSAKTPIGALTCTRFMDFSSKVEETVKGGNDASPLFSSLPYMVNLAGTMMLTPSPSYTLHTVNQEWIAEEKAKHKSASPVGYVSTNDIITSWAFRTTKCDVGFIAINYRGRIDGVERHLAGNYESAIGYQPEDYATPALIRESLATNGFRRARSGAFPSMWSKTSTFVSSWISLYGPAELPRWTMIEHLPSASGNVPFTATIVVFQRTPSSVGVLAVSRVDLTGDNDAAAALTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X4Z8</accession>
    <name>A0A6G0X4Z8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_008455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000102">
        <property type="protein sequence ID" value="KAF0734982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X4Z8"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0734982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="32494" checksum="F61AECE31C3539DE" modified="2020-08-12" version="1">MLFESEEWPSLFSHLTKSNEPIMTLEHKRLLYESILTKSEDESEAQNQLIVVSDLLNFILVRQPQQRPDLKAIHDKLSNYELQLADKSIPLTPALTPIDIMCNQVRILDMHRPERWDKIKLFHRIYLGCKAEWDGESVLYLTCCTNTATIRPTSCLAVPQPHSTSSSAQEIHFAEHFLKQVQLLCKLLWDLYLTNKTVLVSVTSQEMLRGIMPAMFVFQMTFFGLSTFEIVKQLWRPNDTALIPKNEDLAAILCWEEKRCWVSFSTPAYQVVFQQSQILM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X507</accession>
    <name>A0A6G0X507_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_008280</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000101">
        <property type="protein sequence ID" value="KAF0735065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X507"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015536"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052706">
        <property type="entry name" value="Membrane-Transporter-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43310:SF2">
        <property type="entry name" value="SLC26A_SULP TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43310">
        <property type="entry name" value="SULFATE TRANSPORTER YBAR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="403"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="460"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="6">
        <location>
            <begin position="512"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0735065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="744" mass="81074" checksum="F94DEB08BD0F4C2F" modified="2020-08-12" version="1">MLDPSAVPSLRESIRSKSTEYLSSHEGKRSRGSFFAPATVVPNESAPLLPLHNTTKCIDLDVASVEETTKPTWSGYVNEVGINCLSGVIAFMLTSTIAVSTANVLVGTSGPLSAYVANAIDMHLLGTALMCVFLSWRSSVPYAMGAIDASVVPILAGMAQSISHRLGHNMVIAVPTVLVASALSSVFIGVLLFSLGYFRVTSVVNYLPYPVIAGFLSGLGGVLIKDGIEISSSVSFPTSLETIALVLPTIVFAVLATAAKQFHISPNVVFPTLIIGSIVGFHIIASSASIDTAPWLFNWSSKMLRETPRWYSWAEIAWSEVSWSVLGLAFLEIVPTLLLLISLKYSVLIGSLSTIFRQNVNVDFEVETIGKANILAGLLGCCGGTHYVSAMALMANFKAHPRAPVLICAVLLVLLWGVGLKPLLVIPKFVFGGLLMYIGFHFLENYMIAPAAFLSRLEVATILITFLTFLTLGVLPSVGLGVVLSMLTALMDLHVSGCVKDCARMHDNATFMLRLHGNLSFANAMQVLDLVKSQWLTLPYETLVLDFESVLLVDGTFVQILRRAQGVADNCHFEIHLCHVPTQIQSRFAALKIRRHESFHHFMDAHHTNVAAKRGNQLYDSWNTFVQHHVAFEKVAPVVAKYLDEVENLPPQTMLRADYDISWTFLCVGQIEVYDASMQTKLGVLQPGDIVPVVPSQNVLAQSNCVVLRIRAESWRQLQKAAPSVAITMLESTHRAFGHRAVQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X576</accession>
    <name>A0A6G0X576_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Myb/SANT-like DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_008347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000101">
        <property type="protein sequence ID" value="KAF0735135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X576"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014646"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044822">
        <property type="entry name" value="Myb_DNA-bind_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13837">
        <property type="entry name" value="Myb_DNA-bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="1">
        <location>
            <begin position="19"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0735135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="251" mass="28037" checksum="76B0FB6B9FFB91E9" modified="2020-08-12" version="1">MPTISSAPKKEDQVKNAARWNEEAVERMFQLRYKDFAGRFDHCKNTQAKKEAYILLAAELSLQMGVVYDATQVQNKFHELRKKWTSPSLTATGNGDLVQPKPQFYDIMLDYWGMKPGLSRDTLFSTEVDILDPFNEPGDDKEPPLLSVESETTEIKLEKKTSERKQVFSARRQPSVKSEKTSSVTQAEALMSGLDAVGKGLNGIGAALAEGPSSTSNDQLVAALERQTDAFVRQADQMQQLLSFLVAKENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X5B0</accession>
    <name>A0A6G0X5B0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_008332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000101">
        <property type="protein sequence ID" value="KAF0735120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X5B0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001010"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0735120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="457" mass="50924" checksum="B49FF505A396A73B" modified="2020-08-12" version="1">MDAAFASHALSDAECKRLASFGPLNMPPQELKKQFFIQSIEDSYGPGLLVLRKYAEQNEIVQAPRTNEGMQAKESLSWFASWMTNCEENANQDMEVQEDIEHVDNDVVDEDAFRTPLKPRHGEIDSVQVNVTATTVTKTTSAHKRSHTTITETVEHREIHAESFHSPVATQPGHVYTLSSVELTSPAPVSSDGSSRLWVQLPENTSNEITPSAKQAAHAPPVGISPVIAASKKKIAAQPKKRHFEDVAPEKPAPISEENTSEDEDEVDIVLRHDATPISGPQRRRWSMPSFFNSNTKSPTKVAQSPSSLEELLNLPPDTSSIWERLKAIRMPDILAEGLHFSDDASNQEDDAPNIDDDLCCGFDLMNVDDMNDPHPLTIDFSLTPMTECDHSLPHPESTKSAGPNRPRTRSQRKRRLTRGISLSNLTRCQNTNCDDLQHEWGRFSTCGRLHGRWCPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X681</accession>
    <name>A0A6G0X681_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_008070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000096">
        <property type="protein sequence ID" value="KAF0735504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X681"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016435"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0735504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="473" mass="52975" checksum="AA131E87A803FDF5" modified="2020-08-12" version="1">MSGPRPGTAGLVLRRTRSQEIEYSSGVSLSSSIQPVAAPFAAYPPDISAVQQLGQQVQQAVEMQSSRLDDVQQAVGAQQQFTYEQLMTLHQKQQEQQQQQMAFNDKLMAELQDQRKHQQLLVEQLMAQKQVAEAHERGLHMVAESSVKHEQQLEEMRRRTSARWHAFSAPPSEATPGVGVPPPSVQVVYGFHEVTKAPTFNGSTKVEIRTFMDQYEAYSREIASANAQRPGGAKIHQVSLSACIDPLSVERIAFWEIGKPSHELTEEDWRVYFLSAKDCDPVDMGKLDQAMGKLRMDVSIQSAESRVSKLVSDFESILVKLSMEGFAEAEPKLTVEYLVAAIAPTSVRSRVKDLLKLYEHRGLKKDARLFKAWLSDYMRRYGEFEPLIAKASAGGDKPKETNPQVKRSDKKAKVVAVANVDKVPVSNFTQDKRVCFKCLSPDHNVFKCPKYGENLPTSQLTKSHPSQQKRSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X689</accession>
    <name>A0A6G0X689_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Nuclear proteasome inhibitor UBLCP1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ae201684_008112</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 16">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000098">
        <property type="protein sequence ID" value="KAF0735422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X689"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011308"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090364">
        <property type="term" value="P:regulation of proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01813">
        <property type="entry name" value="Ubl_UBLCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011943">
        <property type="entry name" value="HAD-SF_hydro_IIID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051658">
        <property type="entry name" value="UBLCP1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02245">
        <property type="entry name" value="HAD_IIID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48493">
        <property type="entry name" value="UBIQUITIN-LIKE DOMAIN-CONTAINING CTD PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48493:SF1">
        <property type="entry name" value="UBIQUITIN-LIKE DOMAIN-CONTAINING CTD PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="12">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="FCP1 homology" evidence="13">
        <location>
            <begin position="139"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF0735422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="321" mass="37186" checksum="2E52981CF4FEDB91" modified="2020-08-12" version="1">MSLATVVLVAKWKKEELELHVPHDTSVLQVKEMLYTRTRVLPHRQKLVGINRDGKPAPDHTLLQDLTLKNPHKFMLIGTVEDDIFVDPQSLPKAALPRVFDDFACKFSPGSTEWTHARENHDRLDKMLAATEISLINPFRCGKKLLVLDLDHTLMDITATKDASISIDRFRRPFMHEFLTTVWQKFDIGIWSQTSWKWIEIKLTELGMLTTPDYRINFILDKTSMFSTAGGKNTKVKALRIIWQSFPETWHARNTLHVDDLPHNFALNPRNGIPIARYDCKQPEAYLDRELLHLAKYLVDVCADLTDVTDVDHTTWTQHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X7U6</accession>
    <name>A0A6G0X7U6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_007679</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000090">
        <property type="protein sequence ID" value="KAF0736093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X7U6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008989"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0736093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="46295" checksum="7210079A560E5CA3" modified="2020-08-12" version="1">MLDEDSDEARESSVESISLDGIVVADTISDERRTPPQPVRKKKARTTFEIRQREELQRLRGEVDTLKAKLSTIKTDTTIDEKTPFWRRMAHDERVEKIKAFQENEALREAVDQRATFIDQMRKTLLKKPRLLHQHDVHSEEWQTYRIAATASLRYAAIHAIADRQLGRLNHAFLRAGLLGLDKDTTKAELIVESEHCFIYQIMTQITLAVPRDIIATSIWRVLGGSHASFLPFGITESYEQIDASTVYSRVVDSRDPNMTWHSNLIRKLYSLPDKDVVVIRAVLDDALVPQMANDGVEDKWAWAQVTRVDEDLCRLSLLVQVKLTHNSNDRSTLKCARDLMDQMNRSLSSNEDIESYDSPLVPAMNRLNLGDVANPSVRFFLENSKRIRDAISTALNQVLETNAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X8J6</accession>
    <name>A0A6G0X8J6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Elongation factor 1-alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_007395</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X8J6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021264"/>
    <dbReference type="OrthoDB" id="58898at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03693">
        <property type="entry name" value="EF1_alpha_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03705">
        <property type="entry name" value="EF1_alpha_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000003">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000005">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000255">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_A">
        <property type="entry name" value="EF_Tu_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004539">
        <property type="entry name" value="Transl_elong_EF1A_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00483">
        <property type="entry name" value="EF-1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008969">
        <property type="entry name" value="PRK12317.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="5"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0736376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="447" mass="48925" checksum="783C7E23C21E2BAE" modified="2020-08-12" version="1">MPKEKTHISLVVIGHVDAGKSTTTGHLIYKCGGIDKRTIEKFEKEAAELGKTSFKYAWVLDNLKAERERGITIDIALWKFESPKFFFTVIDAPGHRDFIKNMITGTSQADCAILVVASGVGEFEAGISKEGQTREHALLAFTLGVRQMIVAINKMDDSSVMYGEGRYNEIKEEVTNYLKKVGYKPAKIPFVPISGWEGDNMIEKSPNMPWYKGPYLLEALDNLNPPKRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGVLKPGTVVVFGPTGLSTEVKSVEMHHESVPEALPGDNVGFNVKNVSVKELRRGFVASDSKNDPAKGTENFTAQVIVMNHPGQIGNGYSPVLDCHTAHVACKFKEITQKMDRRSGKVLEENPKFVKAGDACMVILEPTKGLTVESFQEYPPLGRFAVRDMRQTVAVGVIHSVVKKEAGGKGGKAAAGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X8P5</accession>
    <name>A0A6G0X8P5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WRKY19-like zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_007342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X8P5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020383"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056866">
        <property type="entry name" value="Znf_WRKY19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827:SF1">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24906">
        <property type="entry name" value="Zf_WRKY19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WRKY19-like zinc finger" evidence="1">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0736322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="255" mass="27447" checksum="936FE1081B2AF61A" modified="2020-08-12" version="1">MTATSTVQHYIVEPIPFVGAATHLPLAIIQDLQEWMAYCDAQDTRPINVDSPRSPCMTDCDDFASDASSMSPGRKICSVENCFRSVRSKGVCKEPGGQQWCHIDGCTKEAQFSNFCVSHGGGKCCKRAGCSNAAQSQGLCKAHGGGARCKYENCEKSSQGGGFCRAHGGGKRCTEEGCNKGVQRGNKCAKHGGCRTCSFEGCTRTDRGGGLCETHRKDKMCTADGCKRLSHALGLCKPHMRQYRNQTNVQSILAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X952</accession>
    <name>A0A6G0X952_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Protein disulfide-isomerase</fullName>
            <ecNumber evidence="4 13">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ae201684_007495</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="4 13"/>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X952"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010882"/>
    <dbReference type="OrthoDB" id="72053at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02995">
        <property type="entry name" value="PDI_a_PDI_a'_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02982">
        <property type="entry name" value="PDI_b'_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02981">
        <property type="entry name" value="PDI_b_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000107">
        <property type="entry name" value="Protein disulfide-isomerase 5-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000027">
        <property type="entry name" value="protein disulfide-isomerase A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005792">
        <property type="entry name" value="Prot_disulphide_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01130">
        <property type="entry name" value="ER_PDI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929:SF240">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10 11" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026376434" description="Protein disulfide-isomerase" evidence="13">
        <location>
            <begin position="21"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="14">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="14">
        <location>
            <begin position="352"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="11">
        <location>
            <begin position="56"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="11">
        <location>
            <begin position="402"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605792-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF0736482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="498" mass="54338" checksum="A5C5FB1BC90905F8" modified="2020-08-12" version="1">MRFLTTLSAFVMLGVAAVSGAAIEEEDKVLVLTDDNFDEAIAANDYLLVEFYAPWCGHCKSLAPEYAKAASALLENDPPLRIAKLDATANTKSGEKYGISGFPTLKFFKGDSDPSAVKAYNGGRTADEIEKWVIKNAGPAVKIISSADELNKLTEANDVVVLAHIDDAAGTQKDILEKVADSEEIAIIVATTDASVSEDVKAAGSIVVYKKFDERKAIFEGEFNKKDIAEFIGEHNKPLVMTFSQDKASQIFGGDVQLHLLVFADASKDYYPTLLESVTEAAADNKGKVLHVIIPLAETRIVDYFGLKEENLPAIILVNMAAGMKKYPYPAQAADLTEHLTGASLKKFEVDYFAGELKPSLKSAEPYDDSNEAVKVISGKEFETRVMNSDKDVLLEFYAPWCGHCKSLAPKYEQLAESFAGVDSIVIAKMDATENEIDHPKVDVKGFPTIFFFPANDKANPVAYEGAREVAGFTSFLKEHAKKFTLDGETHGKDHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X9I2</accession>
    <name>A0A6G0X9I2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_007081</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000088">
        <property type="protein sequence ID" value="KAF0736631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X9I2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018304"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052050">
        <property type="entry name" value="SecEffector_AnkRepeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586:SF3">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0736631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="230" mass="26081" checksum="3E496465F0175A3E" modified="2020-08-12" version="1">MLRVFLSRDLLHGICQFQDGIYYDMLPLCDLGIPDCEDEMASRREFDRIDEVLTNWYDVNDGLAGVPLLIQCLPRLSPVLVVHAVNYGHLHIVKYLHEKLDVVASCQYKLLDLAAASGRIKVLEYLHSLEHAGCSREAMDLAAKNGHLSVVQFLHNHRHEGCTIRALNGAAMNGHMAVVLYLYKMRSEGCLRGAMNLAYIVGHLDVYNYLNKQLKLLKRCRCQQCPAQVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XAD4</accession>
    <name>A0A6G0XAD4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_006855</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000085">
        <property type="protein sequence ID" value="KAF0737047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XAD4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018589"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044159">
        <property type="entry name" value="IQM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31250">
        <property type="entry name" value="IQ DOMAIN-CONTAINING PROTEIN IQM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31250:SF27">
        <property type="entry name" value="IQ DOMAIN-CONTAINING PROTEIN IQM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0737047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="314" mass="36165" checksum="9D5BF2CC3483A4D1" modified="2020-08-12" version="1">MPRFAAMSTRRRGRNCRQELAKQAKMYSSVLVRGFSTGNIAVVDKRSWLEVCDEKHRYGANLRAYYKEWKRYEGPKPDFFEWLDDESIEVEGVPRTKLESETVLYCDPSERQRFELEIRHGLLFRKSTQEIVDTGEDGWIFVLRDGILYGSEKVTTQVPRIHHTSLVGGECVQTAGMMVVSDGTLKIIYPHSGHYRPSEYELLVLLRFLEEHGIVHQDVLVDVQRVQKVARETVNGVKAKKIDSAHFWNAQKVLDFLEMKEWAWRIDLFYDLETMVARLNSRHQSLDLPSDASSDPVVCACTEGDMVDIIDGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XAE0</accession>
    <name>A0A6G0XAE0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ras-related protein Rab</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_006865</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The small GTPases Rab are key regulators in vesicle trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <topology evidence="6">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000085">
        <property type="protein sequence ID" value="KAF0737058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XAE0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001903"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045335">
        <property type="term" value="C:phagocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090385">
        <property type="term" value="P:phagosome-lysosome fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04107">
        <property type="entry name" value="Rab32_Rab38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000222">
        <property type="entry name" value="RAB32, member RAS oncogene family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030697">
        <property type="entry name" value="Rab29/Rab38/Rab32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF39">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0737058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="219" mass="24658" checksum="85EA1A0DA20F7A87" modified="2020-08-12" version="1">MSHTEGRVEAAQDAVVKVLVLGDAATGKTSIIKRYVHNVFSEHHKTTIGVDFALKPVTVQNTTLRLQLWDIAGQEHFRALNRVYYKDALGALVVYDMSRQDTFESVLKWKKEIDTKVELPNRKPLPVILCGNKCDLATEEVDRDFMDAFCETNGFAGWFDTSAKENKNIDEANKALVSAILQHRDIFEKKVEPRKDVFRATAAPAQQASQTNSYCCSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XC41</accession>
    <name>A0A6G0XC41_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Centrosomal protein of 162 kDa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_006380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000083">
        <property type="protein sequence ID" value="KAF0737716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XC41"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004978"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0737716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="29249" checksum="6A5F5C1DD945BA08" modified="2020-08-12" version="1">MVIRKLYKKNLELEKALGQAKNEIDRLSQPQAFEQKLANPPTAESVQSIESQKEEYLKHLAAEQDKTIQELKRKLDELSNADIVRKKNISSDIMHALQDEHRPGKNSRAEAMEESSRQKNSYLKLKGDYKRLLLQRTRAISGNTEIDKHAKELLALMERRLVKVEDEREQEIALYNLKLFETEQQNCDEYVAKKMLEQEIQKVAKDVKERDDIDDKIEKCMFGVFERLHQVEQENLKLREAHEKLLAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XCV0</accession>
    <name>A0A6G0XCV0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_005982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0737986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XCV0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020488"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="97"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0737986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="238" mass="27293" checksum="4CA241962C3985F3" modified="2020-08-12" version="1">MPTEIDPSEVDSTPQLQEKKMIKSIVRRERRDSVVDSVKSLLFKPKRNSVQFSVTQTYMLPPRLAALSELYYTKSELEDIQWSAKRASASIDMPQGTVLVQSFLTVLLTKPTWKQKPKAYYVVLRDQNLLVYRNQKDAYDEHVMRQMQVAKAIAIDHDVQSNESRDIPTVAYTFAVVDREESYVLFATESSKAKSAWLTALQHCLAQSFAEERFEDTLPCGKNDAFTHSQSTNNMNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XD85</accession>
    <name>A0A6G0XD85_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_006110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0738125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XD85"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021006"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="START" evidence="2">
        <location>
            <begin position="159"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0738125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="456" mass="51236" checksum="FE58258E5B2936EF" modified="2020-08-12" version="1">MRQSSAPNEESKAFAESLSDEDLEYLKQVARKTCARVASASRMDTGGSVAWEPIGHKDDVDIYIGESGEDRKTKTPTSLRKYLCGVTHIPATIDDIVHFFHSKSELQRLKNEGKTKFNAFEREILNTKTLYKIRKRTSNNPRHCITLKWMRLGSTVEQIEDRDFVFLECQDTIFDEKVQRRGWVCSMHSVQLPGCPPLDGYVRGSMYRSGYVFRETETPNVLQVVCIMDMDFKGELNVNMTNLMLKARVMIVGSIREHFTGIQEQLHQPQDEDDAQPCPLCEDYLASTPCVSCDQVVCMNCCELVDEDHSVCSVCISQGKVDEMMATQDNDTDDDEGVSIMLPHPRVQPVSNHSLDEPPNQNDASDNIEPIEDATQVVEAVKIQAPGFFAGLWASSAMPSQPTKDEEQTDATYVEPDGTDPLYKLAVERLKAAATAEQQDTRLALVNLYYQHSIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XDS4</accession>
    <name>A0A6G0XDS4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PRELI/MSF1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_005785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000076">
        <property type="protein sequence ID" value="KAF0738348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XDS4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015381"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006797">
        <property type="entry name" value="PRELI/MSF1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037365">
        <property type="entry name" value="Slowmo/Ups"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11158">
        <property type="entry name" value="MSF1/PX19 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04707">
        <property type="entry name" value="PRELI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50904">
        <property type="entry name" value="PRELI_MSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRELI/MSF1" evidence="1">
        <location>
            <begin position="78"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0738348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="267" mass="29469" checksum="F4634C287B4E3ED7" modified="2020-08-12" version="1">MVPASQNTTSHDFYANYDLAMKRQDAARIFCESASIVAFPHGLSSSRKGTPHLSFDFVPHPTHAVLSLSVNSHSDEDMVLHQTTEHVYPYSWDVVTRAFWNKYPNAKLAHVERVDVLSRYIDNEGRLHTARLAKCTQNNMPSWAVKILGKFSYVYEETICDPVAKTLLLKSTNLSYRSVATVHETCFYQPAAGPDGAMSQTMYTQDAEVSAFVPFVSQKLESLSVNRGAETAARGLSAMEAICKDIFQGQTAFCDSVPATSAPSPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XEK4</accession>
    <name>A0A6G0XEK4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_005679</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000074">
        <property type="protein sequence ID" value="KAF0738448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XEK4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004357"/>
    <dbReference type="OrthoDB" id="78057at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0738448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="158" mass="17484" checksum="2D2897FF07C1E49E" modified="2020-08-12" version="1">MTAMCIFYRCQNPADGSGRKCIVHLNRTPCKAFQCPNQAYARGRCVRHGARKLCREQGCPHHRRAGGYCARHTAAMGLQKKPDRPLLQLEPLAFGSVPPSVVDTDWLEVLDLFQEDRSGANGSMNALSEAPHVMGDWEFLAMCEDPLLDLLTSPPCVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XF41</accession>
    <name>A0A6G0XF41_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tetrahydrofolate synthase</fullName>
            <ecNumber evidence="3">6.3.2.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Folylpoly-gamma-glutamate synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Tetrahydrofolylpolyglutamate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_005485</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + L-glutamate + ATP = (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10580"/>
            <dbReference type="Rhea" id="RHEA-COMP:14738"/>
            <dbReference type="Rhea" id="RHEA-COMP:14740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:141005"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.17" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000070">
        <property type="protein sequence ID" value="KAF0738876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XF41"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004314"/>
    <dbReference type="UniPathway" id="UPA00850"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="entry name" value="Mur ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF5">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0738876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="499" mass="54506" checksum="6257D1C89E4EEAAF" modified="2020-08-12" version="1">MPRIDDLSMDDVEALRSRGAQGALEMLLSMPNSPGNIFPAAGLFTRESANAMMRHYMKRSGVDASSLSVVHVAGTKGKGSTCAFTQSILRAHGAKTGMFTSPHLIHPNERFRINGKPVSDSLFAATFWAIWDALVASESDHGGYPRIPNYFTILTLMAFRLFTLERVDVAILEVGLGGRLDATNVVDRPVVCGVTALDYDHMRILGSNLALIAREKAGIFKPGVPAFTIAQPEEATRVLVECAAAESTSLVVVPPISAQEKVTLGLNGQYQSHNAGLAMALASTWLAVKANSVVPPDHLKLTPTARIGLERTRWPGRAQKLVDPEIDRMTFHLDGAHTPLSVECCVQWFKTCVSSDRQVLIFNCHHERDIVQLFQPLLGIAFDLVIFCPTGSSRSGICKVPSAQEILGKSAINHHHPPQESKDAVDETNPLYWQHQCARVWSILNKAQGKDSTTLVVPSMDKAIQWIRKAYSTTESCVLVTGSLYTVGDALVSLDWKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XF49</accession>
    <name>A0A6G0XF49_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable acetate kinase</fullName>
            <ecNumber evidence="5">2.7.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Acetokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_005440</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetate + ATP = acetyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:11352"/>
            <dbReference type="ChEBI" id="CHEBI:22191"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the acetokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.1" evidence="5"/>
    <dbReference type="EMBL" id="VJMJ01000070">
        <property type="protein sequence ID" value="KAF0738829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XF49"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016810"/>
    <dbReference type="UniPathway" id="UPA00340">
        <property type="reaction ID" value="UER00458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008776">
        <property type="term" value="F:acetate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006083">
        <property type="term" value="P:acetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd24010">
        <property type="entry name" value="ASKHA_NBD_AcK_PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00020">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004372">
        <property type="entry name" value="Ac/propionate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000890">
        <property type="entry name" value="Aliphatic_acid_kin_short-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023865">
        <property type="entry name" value="Aliphatic_acid_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00016">
        <property type="entry name" value="ackA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060">
        <property type="entry name" value="ACETATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060:SF15">
        <property type="entry name" value="ACETATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00871">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000722">
        <property type="entry name" value="Acetate_prop_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00471">
        <property type="entry name" value="ACETATEKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01075">
        <property type="entry name" value="ACETATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ACETATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="216"/>
            <end position="220"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="290"/>
            <end position="292"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="5">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="5">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0738829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="407" mass="43754" checksum="C05D2A0E26AE8635" modified="2020-08-12" version="1">MSKVKILVLNAGSSSLKYKLFAEQSAKALTPLVSGMVELGPTAKSIKHATYSDKSTVKASLPPVVLADHKSALSYVIDLLCDPKHGGLKSKKEIHGVGHRVVHGGEAFHDHAVITPEVLKGIQDNVDIAPLHNPANILGIQVAQDLFDCSQVAVFDTAFHATMPPAAYLYGLPYNLYKDYGIRRYGFHGTSHQYVAEQAAKHLGKPIDQCNFVTLHLGNGASMSAIRNGKCVDTSMGFTPLEGLVMGTRSGDLDPAILPFLHSHAKLSIAEIDTLLNKKSGLLGLCGEADVRSIQDRMLAGDARANLTLDVFAHRVRKYLGAYLLQLHPKVDAIIFTAGIGEQSSILRERICANLTHVGIKLDASKNVPGPSPTIRAIQASDSDVPVLVVPTDEEKCIAEITARLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XGE3</accession>
    <name>A0A6G0XGE3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_004901</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000064">
        <property type="protein sequence ID" value="KAF0739332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XGE3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0739332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="312" mass="36495" checksum="0C5F2A6522AD51C6" modified="2020-08-12" version="1">MTLQCHFGHPKRQLVSYWGSQDAIVEEQKAKWRYDKVHEGLTEWEQDHPSFKAWNVQHIQLQMLLSDVEDRWKKAQENARLSGSRPATTRNTMKNAMRLRNHVSAALREWKSEHPNCDILDPERQQLLELRREADKRLMAAREVADVLKSSGSKKKRKKYSDMDIEESCRKFLDAIARKLAESYDFPREFEDFAIMEDVFRAIDSNTWTRKSAYQVSLPEFYPNEEWQALRTLLDDTIDLRNKNREPFRTSRGEIVVALPHDGFENYCHVLKKVAQICASCGDDGDWDPSALVFIDEQDLGFASTLLNDQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XGU4</accession>
    <name>A0A6G0XGU4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Chromodomain-helicase-DNA-binding protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_005031</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000064">
        <property type="protein sequence ID" value="KAF0739466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014374"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17995">
        <property type="entry name" value="DEXHc_CHD6_7_8_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF11">
        <property type="entry name" value="KISMET, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Chromo" evidence="8">
        <location>
            <begin position="323"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="8">
        <location>
            <begin position="405"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="512"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="837"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="311"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1092"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1340"/>
            <end position="1470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="138"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="156"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="199"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1092"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1117"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1340"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1350"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1361"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1392"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1412"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1447"/>
            <end position="1463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0739466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1949" mass="222293" checksum="05AAFF1B92356546" modified="2020-08-12" version="1">MADKRKLPDGPAIEELASSEDELSEKNLRKRLRQAPFLEIDSSQEKDDGEIQTDAAPTVQSTDSGRPRRSTREASKVLTEPPKVLTELPPPRRAGLRTKAPPAQVALDYDTFLQQNGIEEKPRGMGRRPARPKVAKRSYSSESFESNSDSSIASVKPKRGQTKRQRKPPAKTSAAKPTRSKTKTKKNDSDSSDSDDYEVPQKDPPKRQLTKKNDSSDDSSQDGGSAFKKRRGKKKKKDDSSSDEFAEFRISGADNTLSNEEDEGFIIDKILARETHTPLEWKKKCHSMQTHYVTNGSIFVEDDEIDGAVTDKKAKANNEDKDKPSEDVAKPTTDDDNEERVDGIEKFLVKWRNLSYLHVTWETEAALIDYEKNAKGKIQRFLDREAIQMLSDDMQGDEYFNPEFCTVDRILNIQPSEVPNVGKPGFQMEYYVKWKALSYDECTWEQEIDVHDDAAVATYHAFNKEPPPSAKSVSGSKRKTSKFIPYNEHNPIEFKNKMELRDYQLTGVNWMIFNWYNNRNSLLADEMGLGKTVQTVAYINHLVTKERLRGPYLIIAPLSTLSHWQREFTSWTNLNAVIFHGSQEARKIIESYEFYRNSKKGGKANNYRFDVIITTFEMCTANDYLTLARIKWQLAVVDEAHRLKNKKSKLSQVLEERFHYENLLLLTGTPLQNNVEELWTLLHFLDPVKFDSADNFISLFGDLKDSSQVERLHSELKPFLLRRMKEDVEKSLAPKEETIIEVELTVLQKQYYRAIYERNSEFLSRGNKKAHAPSLMNIVMELRKCCNHPFLIQGVEERELHRIQKEQPKDLVGSKRQEAVHQQLNDLLVTSCGKLVLLDKLLPRLREGGHRVLIFSQFKIMLNILEDYLRMRGYPRERIDGSITGNDRQAAIDRFCDPQSSSFIMLLSTRAGGVGINLTAADTCIIYDSDWNPQNDLQAQARCHRIGQTKSVKVYRLLTSKTYELHMFHQASLKLGLDQAVLGGIRQVKSSTKGPSKEEIESLLKHGAYEMFKEEKEGDAEAASKKFSEESVDEILSRSTTVIHDPKKQEKNLFSSSFSKATFVSSTNPDEQVALDDPDFWIKVIGLTGMPEEEKKNKTPEKRRCRGRKVYTEVGSDDDRNPDKDGEYKFEEISSSTSDEEDATPEVKTTYSNVHKFHQNFVTALLTYGFGRWTKIRMSDPILNKFSILKIKEYALGFLVQMLRVACMDNIKEGIDQAASNSAATIQAMNKMAIKYKFVVYWLQVVYREKNPTSQFRELYDLHQIPVQEELQRLNVVASLSKSAGKYLQQLEVLFVLDQFIMRRLSPMIEVLSVLHEPFRSNTDGDVNMSSQSVVRKLDLDSEHSKTDGTNDSTANPSSTDEPKTDAETKPSILDEAKRSPDVDSKPTTAQEELKPTAKMEVEPTTSVDTKLATDVEPKSTTEVDSKPNPDVQSKPSVENAVPKTNGEATQASPSSDKSTGMNSPPRPKPEILAKWKQNIETLPPLPGIAIASWWSSPQDDVRLLFIVHRYGWLKGSKQQFQQIRTDKLFFPHGHPGRLESSTWPSLAVLNKRLKAIIRNWADKAVPMSWPPTKAPPPPAPQRQEIRPANNKGIHSAVPQVSLQHAKSSQAFLQQMWERRGRFMGLIMSHGIPDIRLCANAAEEREKWRYFHFDNVLRAKHLTPQDLYAEAMSLEQACRFAVAKVKPPITTERSAFGAFRFDWVLTFDQAQALLHRIELFRMLRLKVLILRPADLHATMNLVAEQGFYRKPTPVWWRSPEFDILLMQGVECYGLDNHIHEMWSLFHSYTPVRNFPNVAWVDSTVTACATAVVQARYGPEITPNEQAAVKVLAEAGTPKPEPVKPPIVENIQREQLLMALEDPHVNKKAFMWYMLQKKEAELNRPSIDQLKQRAKRDLVQQQIEQERQMRKRELESKQKAAAVAASAVPRVLPPVTRRPEPEVIEIDDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XHY6</accession>
    <name>A0A6G0XHY6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">THH1/TOM1/TOM3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_004531</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000056">
        <property type="protein sequence ID" value="KAF0739950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XHY6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007234"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0739950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="40998" checksum="F8A32340DA19D6DF" modified="2020-08-12" version="1">MPEPCPFGHRGPRNKKGECTLSYLDGDLDLSQKYNALRITCAVVGIVGLLACIRKLYILRHVGGSSIQHQVYILLIVSSVAFIARSIDPMSYATIYPVWISGLLCDVASACLYTIMILYAAFYARVVVNPIEMVKYDFFIQGFQWLMIFLTWATFVGVRSIYLWSNPGRGTFQAWHILMQYSMGSILLFIISSTALYFGLQIHHRLKIIHEANERTLAIAKARKRAAASSCTQSPTHPQSPGPILLADDAAATDEMNHGIDMRILRVLILTELYALGVIGLQIWCLVSFVVHDKCILREEYNCSVVGGQCKMGFPFIPLVQFIGGVFFYWSFRKTRAASLSSTNSAAAPSPLVPPPRLPHASSSSRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XI37</accession>
    <name>A0A6G0XI37_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_004648</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000062">
        <property type="protein sequence ID" value="KAF0739756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XI37"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000682"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24184:SF11">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24184">
        <property type="entry name" value="SI:CH211-189E2.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="95"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="144"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="177"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="606"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="621"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0739756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="673" mass="74585" checksum="3A631405D4B96D17" modified="2020-08-12" version="1">MVLHRCQFLFVSVTSAMDAPKTDESPALDPAVDEGDIIEAKAELPPRIDVLYQLHATEADQAAGHALLQHCRDGSVESVKQLVREGAPVCFVTTSGWTPLAVASFNGHLELVQYLLSIGASGYYKEQQQAPSSPSSQGNKKCNLQNTPLHWACYKGYPQVVAALVAFGFSVDDADSSGNRALHLACSNGNFSVLHIVLAHTTDFAAKNMYGNTPLDMTTDIVTRKLLKKLQTQSTCETCKELFSRTRRPTLCHQCHAINCDIDPCTTSVEVPWSADDSAVHSIRYCRTCIQFLTLVEMELEAVLAAKTSHISESLVKIHELELEVRAAAIPTAISTEDATSVISQVEPVAKDVQVKALIQALGQLDSDVADIEALKTAISDAQEKSANAWLIKRASESYKQLTAHTALVNEIKRLLVERPIKVRSSIDFLRKSWRDAKAEHVSPILVEAAQRVIVMAESEVTLYGYYMLSARIDVGSKVYLKDMTKLANAISTVEDKGVNETLLRNARVLRDKLFAEMAMEDALVNFEAQNDGSFAFIDGTRSSTLLEALNHRNHVVTMAVETATKMEDSTPISQTMMDQAKELLIKLKKDIKDEQKVKAWHVNDAAESEVRSTKTNAASSRRRKLRRRPRKARRGKRKPRDKDKYVDRDNCILITSHHTLIGFAHETISSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XI53</accession>
    <name>A0A6G0XI53_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_004626</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000061">
        <property type="protein sequence ID" value="KAF0739818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XI53"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0739818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="141" mass="15308" checksum="613CF2AC8F3F9512" modified="2020-08-12" version="1">MRGLRSNTYTQHFTSVKCRTISHLQSKYFLAFNNLVLFFGTADQVGQSHVAFTLATDVTGQGVHVVLTSVDAVGINLGDSNLHRGVVLGRKDAVGPRALAGDVDINVLASFVLHLGRSGEQFTNGPLSMPNGLRNLYYLIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XIF3</accession>
    <name>A0A6G0XIF3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_004499</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000055">
        <property type="protein sequence ID" value="KAF0740058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XIF3"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0740058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="112" mass="13158" checksum="09C2B15E64A4858E" modified="2020-08-12" version="1">MGNGSFCFDIRNQQQRFGSTALLLCGSSGKWQVAWQWQWQWQWQWQRQQWQWLVVEASGNGKWQWRQQQQWQVASGSGAWQWQKRQVAAVAVAAAAVSSGSGSSRKWRQWQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJK7</accession>
    <name>A0A6G0XJK7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_004089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000052">
        <property type="protein sequence ID" value="KAF0740350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJK7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012272"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0740350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="120" mass="12730" checksum="A3D6953FFDFB0FAE" modified="2020-08-12" version="1">MSHAYVAVYQLYCPDDAIYSLNCQTRANAALSIALGVAAVAVSTTDATDESSRCRKDASQRCEHLKLALSIALSIDALLLMIASIGLLRPARGIDMEPKTPASTPKCIGFSSTQLPTKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XKE0</accession>
    <name>A0A6G0XKE0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_004025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000048">
        <property type="protein sequence ID" value="KAF0740652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XKE0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009226"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026117617" description="Methyltransferase type 11 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0740652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="33466" checksum="EA951ED3C4EAF84B" modified="2020-08-12" version="1">MGVMWWKVGLLLAAHHVWATPGGPARRVCSSASSIPSMVTSDRLFRSIEVKEEEHHASSCISSWGRVLDAGTGDHSLNWLTSLPIDSLVAVTGDKPRSLSLRKSFPQPNVEILAGNWNDPTFLEGQEFDVVIADYLVGAIEGHAPYFQDEIFPRLFKHVASGGRLYVVGLQPITMTLDPAKRKTTQEKLVLEMQRVRDACILLAGHRPYREFPLDWILRHLSHAGFNVVSHAFFPNRYTMSMIKRQIAVGRNKLPLFLDKNFANSMEAYLSELDRQAEAATTEGPFEFGFDYVVAATKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XKI6</accession>
    <name>A0A6G0XKI6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_004027</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">May play a role in vesicular transport from endoplasmic reticulum to Golgi.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Golgi apparatus</location>
            <location evidence="1 8">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000048">
        <property type="protein sequence ID" value="KAF0740654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XKI6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009228"/>
    <dbReference type="OrthoDB" id="10262857at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14942">
        <property type="entry name" value="TRAPPC3_bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000001">
        <property type="entry name" value="Trafficking protein particle complex subunit BET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016721">
        <property type="entry name" value="Bet3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13048">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018293">
        <property type="entry name" value="TRAPP_I_complex_Bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR018293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0740654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="185" mass="20619" checksum="4328F89529BD9754" modified="2020-08-12" version="1">MSRVRAGEAAWAKMPKVNAEFFALTYGALVTQLIKDFEDLKEVNTQLEVMGYNIGIRLIDEFLSKSGVSACADFKDTTDVIAKVAFKMFFGVNVDVAPTDSPNVCHLILYENPLSEFVELPPHAHGVLSYSNILCGVLRGALEMVQMRVEAKFTKDIVQGDDVTEIRLELKGMIEETMGDEYKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XMA6</accession>
    <name>A0A6G0XMA6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_003232</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000036">
        <property type="protein sequence ID" value="KAF0741550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XMA6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021883"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008506">
        <property type="term" value="F:sucrose:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432:SF26">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13347">
        <property type="entry name" value="MFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="452"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0741550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="481" mass="52500" checksum="82758BD221430B3A" modified="2020-08-12" version="1">MATHVQEAAVPVTPNDVDYVQKDADGLDVVDKSQQEGMSIPMMFLVCCPKMAMNMAWAAQWAALGPLLQVLLSYSSVQGVQLVGPTAGLLVAPTIGVLSDATTSKYGRRKPWLFWGAITSIMCWAVMMNAQDIGESLGDKGDDRTWTTVFVVICYVWMDITCNLTQVPVVLLIADLAGNRQVTAASIGQVWSIAGSFVVSGYIMFFGPAHQSIKPFMGMLMGIMFVTCMSVVWFVKEEQYIPTVKPDTKQQLKDAFSALWVGFKKLPKVLLIYCLIFLLLQYGYTAYNGAKGQFFGIRVKDGLAENADKCGKEGQPECTQRQKDYNDGVRLAGGVTDTVFNLFGVAYLAIMPFLVRKIGAKWVIVIACVPQALLIIMSFCKVIAIDMILVILTSISQQTIFALQLPMIVYQIGLAPDNDLGMYAGAFNSANCAGQFLNFALATQLVKTSMTFALPVLVGGILSAIALLVAIFFLKLDMKTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XP00</accession>
    <name>A0A6G0XP00_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_002926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000032">
        <property type="protein sequence ID" value="KAF0741985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XP00"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005449"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0741985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="275" mass="29519" checksum="ED75EC95C3EE99E6" modified="2020-08-12" version="1">MANMSMQFLCNMTFTPIIPGAAPAAAAPANNNMETATQRRRRQRAASVQRRYQAYEDRLNRRSYDRNDEPRGYNNRPYYNAHRNADYSNRDPRPPQHGWGDLPPQTAGGQDAIQHGGWLVPIVPQARQNSVAAPIDVSQIDAEEALPQNLDAAQPASVEVIDLVSPETVAVAEPIEALQPVDAQAPLEEASEAQEPLDAPQTDIGEAQPEALDTADAQPRAGDPEVGAQAPVEVADDVDMHAQEVADTQATANVNLVAGDDDDAVAPLDAAGPIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XPE5</accession>
    <name>A0A6G0XPE5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_002807</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000030">
        <property type="protein sequence ID" value="KAF0742136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XPE5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004603"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005216">
        <property type="term" value="F:monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07346">
        <property type="entry name" value="ABC_6TM_exporters"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000604">
        <property type="entry name" value="ABC transporter B family member 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF620">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="441"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="283"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="643"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="930"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="958"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="972"/>
            <end position="982"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0742136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="982" mass="109665" checksum="FACE475848251CC4" modified="2020-08-12" version="1">MTAQDVRADSQDRSMRLRFLQFIDCKPWHYLVTLLILADFVANCVVTSVTSQETFHNAAAATRFASTGCAVIYIFDMVGRIWCLRHAFFRNAATIFDGVVLVLALLALAARFVWADNPDEAIITEGGWTNKHHLFHEIKTNQIEQYIAATYALFMAMRVGLKPRARTFSKKLHKYAKHDKLQISLSTLHASLRRIPGITAAAVDMMETDLAMICGRQDGYMGREELMRFLQKAMMYRPADLSVDDFLAYLRNVDATMVEVTYGAHDVVRSTFRHWSTQRFDLFVTFLVVIVCACIVPAMAYFLQILTDEAFPWYITSYPDIDPFNVEVVPNVTVQIVYKSRMADENGTNQEDSPLMFVPAESLRFGMYGILALVVPYVLCDYAIGYFQSKMIAKATQRVQDDLLRVLMGQPIQFFNDRTDGDLNNLFQSDIARVNTMWQAVFWNLLQPIVTILIGYGFLLYTQPVLGIMCFAFAAIIVTSGPQGLAASKSEDFGKKNAYVSAEYQNAISCQKVVRAYEFQKPLLSKFGASIQNLAAAQFGKDFWSGIVQIYIDSGMFIYVAVQTACLAIKVFHGDITPGEFIACSTLLNRVSNPVTVLGGFMRVAISNASSLQRLDFVLENTATNQSNDDNKKPGVPAMKKGISLSHVNFQYTGDKLSLQDVTANFKQGEYTCIVGPSGCGKSTLLNCLMQLYDVSSGIVAIDGMDLRQYSKRSVRDQTAVVFQQGGILNGTIMENIRYGHANATDEDCKRAAQSAECLDFINQLKDGFGTIVGQHAVVNLSGGQLQRICLARALVRKPSLLLLDEATSALDSSTEANIVATLERLAHKMNMAIVSVTHRLNTTRNADMIYVMNDGRIVESGKFNELVGNTNSFFAHMIQMMENTSNADEPSRRSSLSMNPYAAADDMANLVETHQALMEYQRKLSNRSDENELSVWRMRKSSSSSKRQLSRISRRSVQSNGDENANQDTATRSDRDSYIVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XPG1</accession>
    <name>A0A6G0XPG1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_002728</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000029">
        <property type="protein sequence ID" value="KAF0742326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XPG1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005372"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF11">
        <property type="entry name" value="D-ASPARTATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="5"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0742326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="228" mass="25318" checksum="C9B53F7636EFE7A0" modified="2020-08-12" version="1">MSLSIIIVGAGVIGLTTALQLVLDGVPASQIMIVSKDKPEDTTSFVAGALWECPPYHMERSANALKWCKATLDKCIQIMKDYPDCGMHVVPNITVSQQPLKPNTDAQTIASSYRESPDLTSPDTRQFLHSHGAAELQHYKHMQSYDVVIADMGLYLAWLVKQLQRHGVQFEMRDVQDLHALASRGNVVVNCTGLYREDPDMYPCKGQLYWFMHLGSAPPSATKMLVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XPI8</accession>
    <name>A0A6G0XPI8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-MPP</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Inactive zinc metalloprotease alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_002863</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000030">
        <property type="protein sequence ID" value="KAF0742197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XPI8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000762"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF49">
        <property type="entry name" value="MITOCHONDRIAL-PROCESSING PEPTIDASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="6">
        <location>
            <begin position="96"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="7">
        <location>
            <begin position="250"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0742197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="519" mass="56726" checksum="ACC1BD0D3CF77A36" modified="2020-08-12" version="1">MVRIQVLSQLKKSSSAALSVVGYGRSFCSAKHPTISHYVHSKDAEEPAQGILKPDLSSFKKLPSLDEPIPGLPVLKPASQLQAPRTETTVLPNGLRVISQETYGQASTVGLFIDAGSRFEDDSNTGITHMMEHLGFKSSLTRSHAELVREIEEIGAQTTTSSGREQLIYTVDVLRDNVDRALMLLADAILKPAILEEEIELIKVIMRIQSEDLKENPQQYLQERIHTAAYGGNNTLGRPLQCPLDKVNRLNRDSVVAYMKKFFVAPRIVLAGSGIEHSVLVDKAKAYFGDINAVTEPVVATPAEYIGGLEAIEQLDGPFSYASLAFPTGGWHHEDLVPVCVLQTLLGGGDSFSAGGPGKGMYSRLYTHVLNRYYWVESAQAFTSLHGDAGLLGIYGACMPEATGQLVGLLVNQLLSVALHGVDATELSRAKNQLKSSVLMNLESRMILYEDIGRQLLTYGERESPESICAKVDAVTADDLQRITREAMQHRPSLVYMGKLSDFPSYDNVAQAIAQVLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XPJ5</accession>
    <name>A0A6G0XPJ5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_002853</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000030">
        <property type="protein sequence ID" value="KAF0742186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XPJ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000771"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0742186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="215" mass="24725" checksum="71B2D20FC513DCD0" modified="2020-08-12" version="1">MVTLKWGWYGTEMTAEPVDTADKLYGEQIPVVDPAKYRDLAFLNEGEPILSSMTLSHAQNAQRLTELAEEFPFSSEFIRLMTSKELQEKIPSATGAYFKLGEPIYVEDVDTTVLLFYSDQQGCILWYLVLDGPYEGHVLASMNQLDALDEDEDVQSFWEDQVYVSASSFAEFIHRAWLENQIWFKLNDHVALSSYVDRECDWYEGENAKLGRTCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XPP5</accession>
    <name>A0A6G0XPP5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_002562</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000027">
        <property type="protein sequence ID" value="KAF0742464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XPP5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009366"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141052">
        <property type="term" value="F:histone H3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003349">
        <property type="entry name" value="JmjN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048615">
        <property type="entry name" value="KDM5_C-hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004198">
        <property type="entry name" value="Znf_C5HC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694:SF33">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02375">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21323">
        <property type="entry name" value="KDM5_C-hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02928">
        <property type="entry name" value="zf-C5HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00545">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51183">
        <property type="entry name" value="JMJN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjN" evidence="4">
        <location>
            <begin position="102"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="5">
        <location>
            <begin position="264"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0742464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="627" mass="72160" checksum="6338AA92ACFD700A" modified="2020-08-12" version="1">MRGRGCGRGRGRGRGGGGRGHDRERSPMGASDTTETESSDDSDSGMTEVTQPPTVSRSGRQVRAVRNISQDSHDENDRMLHLAMSRSTKETNYTEMKPMPPARVFYPTVEEFANPMAYINHVAKEGARYGVVKIVPPKGWNPPQTIDFDEDKIVFETKLQKVHRLQEGKSYKDGRDHTIKSYRTAADEFKQNWFAKRGVAPESWTARDFEREYWKIVETSSEPLEVEYANDLDICHIGSGFPRISRAQRDDREQEHVDFKSKAYYEHTAWNLNNMPSARGSLLRHIDADINGVTVPWLYFGMLFASFCWHAEDNYMYSVNYMHSGARKHWYGIPASSCDHFEQIWKSTVPERFKKKPDLYFHLVTMVSPTLLRQNNVEVYSLVQEPGDIVITFPQGYHCGFSEGFNCNEAVNFVLPDWIPFGHRCNERYRLFRRLSVFSHDRLMYVLSMKPFTGDWTVLGTNLLLDEMNKLVKEEVELREQLIRSGIQEVIAMSKRDINLTDDEMGYDDKRQCMLCKHSLFFSGVACRCSKTKVACLRHATDMCRCPPSDKVFLQWFTVPEMVAAIQNLELRALKLTKQEEEPVVVATSPPIKRLKVEKLESDVSCRTTLERQQQPLASYSLSRILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XQN6</accession>
    <name>A0A6G0XQN6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Temptin Cys/Cys disulfide domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_002253</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000023">
        <property type="protein sequence ID" value="KAF0742856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XQN6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004300"/>
    <dbReference type="OrthoDB" id="129121at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057626">
        <property type="entry name" value="S-S_Temptin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055313">
        <property type="entry name" value="Temptin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34737">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34737:SF2">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24784">
        <property type="entry name" value="Temptin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026288754" description="Temptin Cys/Cys disulfide domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Temptin Cys/Cys disulfide" evidence="2">
        <location>
            <begin position="15"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0742856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="168" mass="16870" checksum="A6754F42EF609132" modified="2020-08-12" version="1">MFIYKLLVLSTAMVAALQSYNSRIPNANNVLGVQAIGHKNPAGGGASNSFGDAFAKAGNKWTTSLCQADTDGDGATNGEELGDPCCVWKVGARLNTTTATHPGVVNTFTPNTLAALKCVTTTSAAGKNGTNASSTPSSSISVPSTTSVAMPFATSALVGSVIVGLMLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XQT0</accession>
    <name>A0A6G0XQT0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Myosin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_002279</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000023">
        <property type="protein sequence ID" value="KAF0742883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020182"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF845">
        <property type="entry name" value="MYOSIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0518">Myosin</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="9">
        <location>
            <begin position="61"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="8">
        <location>
            <begin position="1175"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="608"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="6">
        <location>
            <begin position="676"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="166"/>
            <end position="173"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0742883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1310" mass="145854" checksum="980C449B66654D0D" modified="2020-08-12" version="1">MDVGASVWVMVADVWQRATVVRTSATSVQCTIQGEKDGNARIVDIPLPHVELCNPDDASSDSMDDLTSLVHLHEPAILHALETRFARGEVYTRTGAILIAVNPFCKLSLYTNTVQQAYMNQGMLESHGDKTQQQEQSLPPHVYQVGDTAYRSMLVNQDAHNILVSGESGAGKTETTKILLTYVAALSSSAAQTGGIRQRVLDSNPVLEAFGNAQTTRNTNSSRFGKFIRLGFDASGGLIGASISTYLLERVRLVSQMAGERNFHIFYELMAGVSLADRMKWQLDAPLESFHYLNQSGCLTRLDGQDDAKLFATTQAAMTTIGLLPSEQTWVFQLLAAILHLGNVKFAKKGHDGSRIADTSTIKAKFVCDLLGVADTAAFEKALCTREIIAGFEPVTMAVTVDRAMDTRDTLAKTIYARIFDYLVDRINGAMVTSVPALQLGVVDIFGFEILATNSLEQLCINFANEKLQQLFARFVFEMEQREYQDEAIPWTFVDYPTNEACISLFESRPCGLWNLLDEQARLPKGSDRTLATKFYDAFLSHDRFNASKLDQAHGAFTITHYAGPVTYKTQGFCAKNKDPVPHEALSALTFSSHDFVADLFEDWHPHDQALPPPAASSTAISARNSYTGGRFPGPSPRNSSNRSSLTGGRPSLQRSSLSSASVLSSTVCLTFKMQLSSLLATLETSTPHFIRCIKPNDTMVPSVFNPIRVRDQLRCGGLVEITRIARLGYPVRMLHDFFLRTFGALGPSEAADTRELVKALALPGLLLGVTKVFMTQEAHESLQALLSKRRVAAATLLQSYVRLHVARTAFVSQRCAAIYIQALVRRRQAVANYKTIRHATILLQAMVRRRQSEVSYQKARHKIILVQSIARRWLAGRLCRLRLRAIVRIQRAWAAIYRARVAQLALACAQHEASTRIQHAFRKKLKEWAVQRDNASFMTDEPETEIHSDHNQEDDDDILDEKVLSPLLKNYTLEWTDRVLGLSFDVSFSSPVVRRVHTSLSACDDITRVQKGDRLIALGSETIRPHDNFRELLLNMAPPVVLTFAPAGGSIPKFSTEMVTLGLAKRPRSMSDVAPDEFDVIVEDASFSWSPYKTHSAMVPMVHGFAGDATTNPGLEKLQASDVLVQVGAVSTASMSYKDALMRLKDAERPLVLRFQVGARRPNSWADHVVVTWSKGSLGVEWKWDTVFHQGLEIQRIHPNGLIAQQNGLQVGDILLEINHQDTRALGFDATQKMLTEHQPTPIQLTFRHMPAWKHQAKVALRVASKMLVRTQESWDDHGDTIQRVVLGILLYCLIFWLDEILFFPLRFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XR41</accession>
    <name>A0A6G0XR41_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_002291</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000023">
        <property type="protein sequence ID" value="KAF0742897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XR41"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0742897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="99" mass="11157" checksum="047881B03EFE9097" modified="2020-08-12" version="1">MDVARVVNTLDFQIPISMNPNLKNSFPSTFVCDGIGCRRVFAWRCTAWIVMCRGEMRSIPNLLRLPCECGTQRFSLDEPSIRTNKYGDGIGSHLLESAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XSA4</accession>
    <name>A0A6G0XSA4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WRKY19-like zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_001838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000017">
        <property type="protein sequence ID" value="KAF0743363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XSA4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012775"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056866">
        <property type="entry name" value="Znf_WRKY19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827:SF1">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24906">
        <property type="entry name" value="Zf_WRKY19"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WRKY19-like zinc finger" evidence="1">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="WRKY19-like zinc finger" evidence="1">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0743363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="260" mass="28073" checksum="3E0BD6412BE140CF" modified="2020-08-12" version="1">MDDVEGLRKCKTEPHFTMDGIEVLHEQIEPIPFHVDVPMQQHATSSVIYGEYLIELSTMLTTPPTPPPVLSAGKDKSAVDEVAGQCLIKGCMRCINYRGYCKDHGGVRKCSVMGCSKGSQGKKLCIAHGGGKKCEREHCSKSAQSHGLCKAHGGGARCVFPGCNKSSQGGGHCRKHGGGKRCTEDGCTSGAQRGDRCAKHGGSRLCRWADCGRTDRGGGLCEIHRRDKVCYVDGCNRLGLKEHGGFCQNHRQPHHIVSLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XSX4</accession>
    <name>A0A6G0XSX4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_001390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XSX4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005931"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052201">
        <property type="entry name" value="LRR-containing_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111:SF0">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0743735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="557" mass="61236" checksum="16A1B22CD489A1DE" modified="2020-08-12" version="1">MTDVVKKTVLATNGSRLLATIEPVDRYAAEGRRVQSTTDERGASLEEAKRLVDEERRRTTTNKLEKFVLDAKFVFRSGGFGLSQNESCIQRLTNLGRVKVTDVDLSNMHLNEMLVDSLADYLASPSCIVVSLNVANTKLVPRQVKQLALACGAKMQFFQASKVRLAIPMLRSRQVVLPRTGCDHLDATAIGAFVAAKKKPQLEVLDLSSNDITGPPERCNLFGGIETLAEAMPKCTKLSRLILNRVNLRSDGLVLLSVGLDTSTSLRVVELGGNLIQTNVSNQVSYSGMDALCEALRATHSIRHLALPQNDLDYTCAAKLAEILRVNDSIESLDVSENPLGTPSMSCFAKALQANVPLQELNLRDTGITGKGCIPLAEGLMRNSTLTALDLTKNDDMMLHDVGLTHLIAAMEENAKLIALKLPETIAPTKQLTDRLEQLTQANVALTSVKRSLASFDFAALSPLSQVNFIHKLNAWSETELRVLATNRSFVDCKLSDGQLSALEYFASFDMYAPLKRLIWAYDAAQRQETSASCSRRRHDEDVLWNDEPLIRLPPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XT36</accession>
    <name>A0A6G0XT36_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_001697</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000013">
        <property type="protein sequence ID" value="KAF0743548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XT36"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004817"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF12">
        <property type="entry name" value="MITOCHONDRIAL ORNITHINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="92"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="190"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0743548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="30541" checksum="9B00CAC0DD8093FD" modified="2020-08-12" version="1">MLDIKETTSGGVGAVCLVYTGLPFDVAKVRLQTSSEYRGVMHCLVKSVHNEGARSLWKGAAPALASAIIENSVLFTAQGALRRIVFGSNHKTSLIDEAMLGGAAAIFSATAITPAEVIKCRLQSSHTASSNVFACIRGILAQNGLAGFMAGLPAVLLRDIPFSFCFFGAYELYTSTLVRWLEDHSSKRDLHPLAVLTCGGAAGATGWSLVFPADVVKSYMQVGNGVGFRQAFDNIRKAQGLRGFYRGWSAAVLRSFPANGALFLGVEMTHRLFAAVENGETEWSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XTK7</accession>
    <name>A0A6G0XTK7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_001521</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XTK7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018329"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0743878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="38067" checksum="1B5E0B43A686FFBE" modified="2020-08-12" version="1">MVPLKLLKMPVPDDFFNLPPLAPDKIQELRAVGYRAQRDLLEYTKLTGGPVEWTLHTNESKVQVYTAREGNLPLFLGTTEVESTLDEVRAILTAPTTSDVRRVNAAYFPDVLDEVRLYTLSTPTEDRPHHLSSVSWTVLGSPLQGRIVRYRDFCNIEHLEDVEMRRVPQEVWLIHEENKLPTLRRGRLQQSLQYKMEIDHGESPSPAPRVHPLYPRAKRSRAGDDALVDADDENGAARRPVRRLRVVQLALHKSFQATAELFVRMDAWIAARSLSISRNAMALSSVTTTQSEASVIYEEGGVFDICDPRVQRSVHYFGSPKGATQRRRGDMLLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XTV2</accession>
    <name>A0A6G0XTV2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">B box-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_001449</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XTV2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002688"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.40">
        <property type="entry name" value="Cytoplasmic polyadenylation element-binding protein, ZZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038446">
        <property type="entry name" value="CEBP_ZZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018553">
        <property type="entry name" value="E2_Ub-conjug_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057668">
        <property type="entry name" value="E2_Ub-conjug_enz_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31560">
        <property type="entry name" value="UPF0652 PROTEIN C16A11.03C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31560:SF0">
        <property type="entry name" value="UPF0652 PROTEIN C22H10.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09418">
        <property type="entry name" value="DUF2009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="3">
        <location>
            <begin position="51"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="168"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0743799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="646" mass="72196" checksum="078E0573FBF9CD73" modified="2020-08-12" version="1">MTDRTELVRLRRLSELLDHDRDDPAGEVDVPAFQIVGSGDATGSVDNEEELDASVCIECRHQASEVFCEQCHDHFCKLCYGGQHRKGNRKTHTYQPILQPGKDMDAASESTATTTLQESRSIEGDDSDDAHENESSSSSTLSSRFRGSSSRNICNLMGSFFLGGYGTSSTTETPAPTPSLSSPNGSMRERAKYIPLRLTYEERKRLRTLEAALNVCHYTDKIDTSATVASKRTRMQLQEIAGFLSGLVISMDYATGQTLLDDKQFEPLAGFFGELFELGRRYKIMNPEKMRGEYGILMYLLQDAVSPAIQDLLGFSPIQPLKTVYALLESHDALAILDHPLIEQATMVVAPEGKSRAKIQAQIKAKDAAIKTITNRFMSSTLRADDIQQCLYSIADNNYHLYFERDPTDRMIQLLTTHFATEDDKYSLAIVSGNDGARLSHSHARQYNYVLQSLTLWREIAHDMFRLWCLTDEDLLAPNSPYQLTDTGQGLHRIQASPRISRAMHVILHSTQAKLDHWVGSSVIHLGDKNVPNALMFIDKYAQVGHILRPIVRTIDEIDVLVTKSSELKAYIETSFGGTEALKKDILVDFFREAFDGSGADNFFDAGSCIDGRLTSAWNWCSRLHGKKFFPIFKLAGFVGFDGKFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XV81</accession>
    <name>A0A6G0XV81_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_000845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XV81"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016835"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0744359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="321" mass="36066" checksum="60FC104A73DAD277" modified="2020-08-12" version="1">MRLRVQNGITQYFVRWYVDTPGYRKSEWADASDVPNATIALAELALYEAYTAAFQSDPSQFTEQKVKTFDEFLKSSSWWQSVGVNEDIACLLQAIRKASLLLQLPFQLSDEVYVQWFHNHKLDAKKAIPRSKLNNFLFTMTAKGFSVSQKHPGSNLVTQKLASPQETLAGILKDAPFVVYLMITTFLDCAHTWTSHRRNRFVVDIYDGISDKALNFEDIPDGVEIYRLLRLVPINVQTPRPKSVSVSTFNNLPSPQEEAISHLIKCNEYPLPSLGAVARQSRGLREFTTEHGFADDANLLAPSLAGFLGGCNLEEGLVVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XVE2</accession>
    <name>A0A6G0XVE2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_000861</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016818"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09487">
        <property type="entry name" value="SAM_superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="3">
        <location>
            <begin position="246"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="2260"/>
            <end position="2295"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="2296"/>
            <end position="2331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1850"/>
            <end position="1873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2370"/>
            <end position="2437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1850"/>
            <end position="1860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="2376"/>
            <end position="2388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2404"/>
            <end position="2415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0744375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="2437" mass="271510" checksum="5F88A0A0D6E082BD" modified="2020-08-12" version="1">MPSKTVAAKDAAVFADAIQREEDKVKEAEEYRIIDGYLFIPHSLRHHFKREEPQDSPAITAARLARSARLFFHSNQHLREHLYPAEVETSIGARIYYERALSKLTDIETKASTKTQLQLERQIVSLVEGCLKNGQCDIYLGLVQPKRTHILYSACSKGSRMQGQILQASEGLSFQCVESQAVVICEDIAADPTIKYFGDQFRCGPFGCFPLVSKSRNLALNVTGEVIGVIGVDSCRLAWKFHPQAMTHEQVVAFLRTYGLEDCIPAIIKHQIDGVQLAALTDVDMEFKLGITRVLSRSKLVDIVAALRDGVPLHVPSLPTWFLHDDASMEFLTQVAARSGKILAKVRMREWLRLLRARTIDGRCTQYDLYHLVLQAITHCVLSVDAASVWRLDRGQPPKVHVLADCDIPQDRLAPFQQNRGIKRVLLHKEGGGKGNMVRGHVAHLGSLDGATPYQISWSDHTVEYFTWEELKPLLAIRPLNPHHFELQQILSQLETQTECVVDVGGQEGNGGVKRWVKTFTDRSASTYVVDMTFQKSRSHVDAAYFVHQLLPPLEEALVCVRGRQRRAAQRHAALHVMKKAVAQLSMTPSQDAQRSATELVTLVANEIVACLPGVEIAIAELLPGAASVEFTYTFNGSTLATKTLTGPSVALSCCLEAQQKSLVVRSFHSLRRIGKPEDDSALPYIFLPLVHDDSPLGFVSVNRFAEVEKGRDDEQHPEYGVLSFLEQATSCLATILRLKRRSHALYQLQALAQNAFVSPLQLFVTTLKSMIATLPGLRRAKLVAIELKSSTATAILDRVDVDLMDVLYRNALQVRRAETLLSTFQAYFGLTTAIMEIILEPTPSRVLPDDYATLVNPPTLATTIDRKAKHAMDAAMHVIVGNEPYVTSWLPALSSPSTNVVLMYTALTPKWLNRADGRFLEMVAASLNELLVTVRGRYDRVRQRIDALTIFQKQCASTATVNAHFESIQAELDAEIRLDLQRVAVDIIARVLTGANVYIGMTEPSRQRIKYTCASEKSCMATKHLKRGKGVSFHCLTAQTPLVIDATNKSSTEFGTLRYFGDRKTQAWPFIVVPIGSFGVLAVDDLSQYGESPPPEMGIVDFLVRMATELHVAIKNTRETTQAYRKQLRERAVHDVLSMCDNGRLSELHVLQRLLTIVAATFPGVCAYTGLVMPWAKEIHFVLATPSSEMEGRSIDVAKTVSGVCFRSQQPVVVPDVGRNPNGLQVFKDTTGPYVCVPIPFVGILAVDTFPSPAGGLYMQHVPEVGVVECLVHMANAVGAHIRARRLADLRQTIQNLFQGNISTFPILFNAIADAIVVNMASAVRVDVLYPDGTLKFTKSKTTQPDSTPSMPSPLPPPLVPFADGVRVVCPFEMTDPKYSGQSHALLVVTRLPNIDWPYDIHIMETIQPHLSECFSLASARAAAAAARAECISRMDMALEELRATPSQVALTKLHGTQLAWLDWMALALGGRGTDVYLGEIQNDTDALVFTGASPQSLMTGIRLEDETLFSFQCIRTQSPVIVNHLTPTSRHVKFCTTRKATRAYCVVPLDSFGVLAADSFGSTSFTVQNVLEAATVAFLKTCATKFVRLLDGTRHNFDFDQLRAAAVAGTHNLRMIYAHAMADIQRNLGYIHCQQVVTLAPDFTGQFCIESWHKTPTRRPMKHLQEHFCYLHRCSKALVRQRVHFDSVTIPMTNLPKTLDDARTHPSGTAMGIELRGSFPCFAAMLDGAFATTPRVALSVYRKPGRSFQPREVAFLRTYLSVVRESYLVALKHLVVRTFAEEALHWARDFVHAKDGFVAQLREKDVDILVSTNVNKIALGTLKPTLKRTHRLQDFAATDLSSALVETTATPLPSATSPSMPPIQNPSGETTKRSKFALFPKKAKPTTGDRLSSSATVPVSQVSQHWEWTCRLPAGRFLLLDIVSKNAVEQEIFVQEGNALAKTCSFIYDSFWNAPKGDERHVGFFLSQWWQQVHVMLAASRLAIERQLRELLDAEVAHTSTCPRAILIIASSALLCCGHKADAMTTARAVLQLILSSESVGHMCDLDPFDPSTRTKVWTAAFRCRTFLQSQPVAPIELTKELSPAMRILLDATLLLQVVSKWLKADFDKEKASWVPVHRAAVAIQCGARCMRARAELARRRRDFRAALTIQCWARQLLARWCLQTKRRSRAASRIQRWFRRRHDKPRLAPKELLENMLAVQARFGVSEKPSEMFSEATFELFMTKGRGRSMVLAEEKRLVEKLRDLAKQRLSLSWEERIDEEVRDVFAYFDYAGVGSISREDTKTMIQKLRIPLQPDELDDVVAMIDVDKSGDVDVDEFCRWYKYEYARLRARSKDCGTLSKADKEWFSHGMALRFIKQQWTACHSKDKYTPIAPSPAPPLVPPTSPAEATQVESPEDDKQGVSQADNDQAESQADDEQISSAAEREQAESSANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XVN9</accession>
    <name>A0A6G0XVN9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_001055</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAPRE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XVN9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009465"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000028">
        <property type="entry name" value="RP/EB family microtubule-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036133">
        <property type="entry name" value="EB1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027328">
        <property type="entry name" value="MAPRE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10623">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN RP/EB FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140612">
        <property type="entry name" value="EB1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="10">
        <location>
            <begin position="10"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0744586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="340" mass="38757" checksum="FA0DCF67CFB0AA7D" modified="2020-08-12" version="1">MAIRKLKARGIGRLELLNWLNEFLETDYTKIEHLADGIAYCQVFDVLYPGKVPLQNVNFHAQYEPECERNLKILQKTFETCGIQKEVAIKKLVKGVFQEHFEFLHWVHDYVHRTYPDAVRTSHAFERRERLVQKAADGTFANLNLIPKFSMRNGIYRKSLNQVLLQQDEVSEHPPSIEAQNEPQHASPPEAIESADHAVKAQATPQFGHSWQHTIEAKGIATKAFNSMQGTTTDVKPRKTKVQVRPEKAKSHKATEGLLKQLTTPLEAELHGRIQDLDNLQVEVSALLTERKYYSDILREIEHLCQQVDDQDDTANTAKAVVLGILAEPLKELPLIDNCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XWY5</accession>
    <name>A0A6G0XWY5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_000663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000003">
        <property type="protein sequence ID" value="KAF0745092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XWY5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019548"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0745092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="152" mass="16759" checksum="BAB6129CC9443E14" modified="2020-08-12" version="1">MPLPDVYADGTDDPVPPKPPDPNPVDSDNMPRNGDTVLTQQVYPGVIASVTDERLSSSRHGKDTRDEIPINWDGSSLDPLQRETIRKLLLEFDIFVTTSKAPGRTDRIKCTINTGNAAPIKSAPYRVSQARRRAYGSGDPSIRRPRPDPPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XXG9</accession>
    <name>A0A6G0XXG9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_000278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XXG9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018125"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052050">
        <property type="entry name" value="SecEffector_AnkRepeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586:SF3">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026217701" evidence="1">
        <location>
            <begin position="22"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0745247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="637" mass="70485" checksum="F9B0AF55181D93DD" modified="2020-08-12" version="1">MSSMAVAAVLLSVELFAVISSYQDGLFHDMHPFRRLKKLPSTTIGLDKARYADALQRFGPWLESHGIDRLPKLFAAVPEIHRTVALLAVFYGYVDVVRFLHEHETLSQDVNFVDLAASNGQLDVMVYLVESGRYDCAPTAIQAAAAFGRLEPVQYLVEGAHIQPKFLAIEDAAANGHLAVVKYLHDHLHDACTTDAMDRAAGNGHLEVVQFLHHRRREGCTFEAMNSAAKNGHFNVVQFLHEHRSEGCRATAMDMAAKGGHFDIVKFLHDHRSEGCTAFAMNSAAANGHLNIVQFLHTHRHEGCTAKAMNAAAKAGHLHVVQFLHKYRNEGCSTKAIDGAAEHGHTQVVQFLNENRPEGCTKQALDLAATNGHLDTVRYLLSHRNDGCTRRAMDFAATNGHFDIVVSLHEAGVKKCTTEAMDGAAENGHLDVLEYLYEHRREGASANAIVLAASNGHFECVKFLFERKFSEHNVCSAIVHAAERGHQDIVEYLTSHSTMSSMAFEMAAGMGLLNAVRMLDPMTLCEVPHAMDNAARSGHLNVVKWLHIHQKDGCTTDAMDQAARNGHLDVVEFLHTYHSEGATTRAMDGAARNGHLNIVQFLHTHRTEGRTKQALYDAYRYHHLDVVNYLQSLDPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XYG3</accession>
    <name>A0A6G0XYG3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_000114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000001">
        <property type="protein sequence ID" value="KAF0745662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XYG3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013762"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000286">
        <property type="entry name" value="PH-protein kinase domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051707">
        <property type="entry name" value="PI-Interact_SigTrans_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336">
        <property type="entry name" value="TANDEM PH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="96"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="191"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="287"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0745662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="429" mass="48398" checksum="15F28C3216E995B7" modified="2020-08-12" version="1">MCRRIVLSFQDIIHEHPGKGIVQLPSRMRITPSTASSFSFVRSFSSTNNSPCPMESSYASVELEPQHSFGLSASLSSRSWLSKYKSASQSRLDAPSILVSGYLTMRRHAVPNWTTRFFVLQENGRLSYYSDKLTRKMGEVCLIKVSLWDGEPFGFMFSTTKQVTYYVSAGSESERHRWLEALSDFRGETSDADHEGYLSKQRTLVPGFRRCYFVLHGTKITQFSDEDTYRTSAAPLATFEVKIAGRWKAESSGLYIQATSGKMLFLCAENDHDVQEWLKALPTTLEPMACAGWLTKQGHKRKNWKKRYFVLRGRTISYFPDFDSSNSRLMKPLGEVMVQQAAAWDGADFGFMFVTSENIPYYVFADNERDVAKWLAALGKTLQPTSSLPTVETKSCPRCGSVLTGSRYCGACGFDFVKFFTPPSSLSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XYT2</accession>
    <name>A0A6G0XYT2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Hexose transporter 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">Ae201684_000105</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-fructose(out) = D-fructose(in)</text>
            <dbReference type="Rhea" id="RHEA:60372"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:60373"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>D-galactose(in) = D-galactose(out)</text>
            <dbReference type="Rhea" id="RHEA:34915"/>
            <dbReference type="ChEBI" id="CHEBI:4139"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="7">
            <dbReference type="Rhea" id="RHEA:34917"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-glucosamine(out) = D-glucosamine(in)</text>
            <dbReference type="Rhea" id="RHEA:78423"/>
            <dbReference type="ChEBI" id="CHEBI:58723"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:78424"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-glucose(out) = D-glucose(in)</text>
            <dbReference type="Rhea" id="RHEA:60376"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:60377"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-mannose(out) = D-mannose(in)</text>
            <dbReference type="Rhea" id="RHEA:78391"/>
            <dbReference type="ChEBI" id="CHEBI:4208"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:78392"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-xylose(out) = D-xylose(in)</text>
            <dbReference type="Rhea" id="RHEA:78427"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:78428"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000001">
        <property type="protein sequence ID" value="KAF0745653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XYT2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011445"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015149">
        <property type="term" value="F:hexose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF8">
        <property type="entry name" value="FACILITATED GLUCOSE TRANSPORTER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="460"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="497"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="525"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="17">
        <location>
            <begin position="120"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="30"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAF0745653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="590" mass="63864" checksum="DD5659B34DC9BFAD" modified="2020-08-12" version="1">MSTSETPATGGPKVVLVEQEQAADVYIPLQDASEAPKQSGPVKEAPSIQDQDVYIPIQDSPMSVSNRDNALSRRTLSRSNSRSFRSSRRSTSRVRLSRLEGMIHEEHAKALIPSGVLWVTIGISLMGAFQFGWLLSQLNFKPFNTKCTANPIPEGDCAMFPGHSSSEWTMAVTSWIVGGAIGAMVSGFPADKFGRKKTLLMNAIVMIVGGTIQVVSNGIYLFSFGRMVSGIASGAAINVCNVLISEISPSQMRGMFTTGLQVGVASGSLAVTTAHYALNSEEYAWRILVGFPIVLGVLQVLLMPFVTSSPVWLVSHGRVDEAGVELGRLYRPTNTQAILNALVHAHEEEVKETAGVNPWAALFTSKYRKQLIIAIVLCSAQQLCGINAVMYYSSNIFASAGVEDPRVGNTIVNVVRTATIILAAYVMDKFKRRTLLCVGMSVMAVSATGILLSLKYQEAIVSVISTGLFVGSFCLSIGPMAWMVSSEIFPDFLHAPAGAVGTMFTWLCNFLVGVFYPMLSNPSNLGVYAFSIFIGCLVLFVLFVKIVVPETAQKTYVEIQGAFGIEVEQCDPVEEDPWGFDDEEPPKKPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W2J1</accession>
    <name>A0A6G0W2J1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tryptophan synthase beta chain-like PALP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_018801</name>
        <name evidence="6" type="ORF">Ae201684_019205</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ACC deaminase/D-cysteine desulfhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000487">
        <property type="protein sequence ID" value="KAF0721213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VJMJ01000356">
        <property type="protein sequence ID" value="KAF0721941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W2J1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004504"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019148">
        <property type="term" value="F:D-cysteine desulfhydrase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027278">
        <property type="entry name" value="ACCD_DCysDesulf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43780">
        <property type="entry name" value="1-AMINOCYCLOPROPANE-1-CARBOXYLATE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43780:SF7">
        <property type="entry name" value="D-CYSTEINE DESULFHYDRASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="5">
        <location>
            <begin position="73"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0721213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0721941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="501" mass="55247" checksum="9D78811CB0FFCD51" modified="2020-08-12" version="1">MLYSILWWGAGICIALLLVVATIMGLLVLMLRAMHDSIGPLPPGDQPIDLDKSPLLRRLPFLRKRLAWTPIGVFPTPVHAARLPNLNGPQKDGQFFIKREDFSSPIYGGNKVRTLQHQLAACAIHHKTHPEAKYLTLGSSGSNQNVATLVHGKTLGLPVHPCLAQADAPDLENTLNLLSILSFNPSVVRLWTKPLGILAAYLRALFVNSDKIFAMGGNNMLGVLGQMGGILELAEQIEAGEVPDIDVLYLPVGSTCTLSGHVLGICLAKHIGMKAFESPGFKIVAVPIHPGIGAAQRNFGIFHSRLSSFLPLFPRFAFSRVSKYLKREGLDVDLEPLAIAFLKDHVELVTDHELIGEYGTHSLPSLAAATLDTTMQVEGKQPEWMASLHDDQQRKAIIPWLCGHFAAKPFARLVDDLQREGEKPAKPLVRLFWQTKSWIQPHGGADEWTHLNQLAKEKPVKEWINKGRAHSLLRRGSVSVPNGNPSTYQYLMTKVQEQFPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W4P8</accession>
    <name>A0A6G0W4P8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_018776</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000355">
        <property type="protein sequence ID" value="KAF0721953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W4P8"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0721953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="72" mass="8143" checksum="C35B0D362C959A9C" modified="2020-08-12" version="1">MVLGCAKTDRSFHPSWTLLGTIRRAMHQIRRAKTRSTRLCNNTINTTVRGIYYANTPNALSTRFISQTRGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W6H8</accession>
    <name>A0A6G0W6H8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_018716</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000349">
        <property type="protein sequence ID" value="KAF0722079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W6H8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019727"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050776">
        <property type="entry name" value="Ank_Repeat/CDKN_Inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201:SF16">
        <property type="entry name" value="ANKYRIN-1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="43"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="111"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="176"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0722079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="725" mass="81518" checksum="C83FF884DA42CF42" modified="2020-08-12" version="1">MPTTSVQKLENSLHDAAESGDTKKIEAILSKGVQVDTLGDDLDDVTPLYRSASEGHGEAVEVLLKIGANVNFKAPRTGNTPLIIATINGYMDVIKVLLNDSNLELDAQDKRGSSSLFLAASSGKSDVVQALLDKSASIDLQDNNGKTALHIASEKGHADVVKVLIKGANIDLKDSVGSTALHYAAGNGHLEVVEELLNASADPSIENLARMTPIMRASMYNHEQVVALLEKHARGENQTAHLDVAGILQDNTAFKRWLQERAAPPKPPLQRTESILPALDWSSVPAPTSQSAGPSMGVTMQFVRQWMDERGGREAFRGLLTKDVCRQFLKPFTQSSTLSLVDHLLSTPGGEKHIRPAKWFVSHAWQYLFVETMDAIENFLDEQDDQDAGFWFCMFNNNQHEPSDDNVDMFLTKFRGSLTSIGRVVMVVHPWHSPESLKRLWCVFELYVAREIKCRFELAMSRNEKQAFIEDMKSDAFPYLDKLSHINCAKCEASKRMDRTKIERIIAPVGYPNLDKMIYECMNEWIQSSIDQQIRIARRDKDSTKLATWLEIKGRFHTEQKDLEKAEACFAEAHGLYNELEKQPELRRTTAASAYLLVLRDEPIAAWESVLNECIVYQTTRLGPKHPDTLASKYYLAIGLFLMRNRAKEVKMLLRECSESLADPTHPRALRIRYEYGRALHRSGENAMALSIIEDVFENQKAVLVCHHPHFVDTENFLAELRAQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W6W7</accession>
    <name>A0A6G0W6W7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_018889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000363">
        <property type="protein sequence ID" value="KAF0721823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W6W7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015072"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0721823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="145" mass="16182" checksum="5355C4A5D800EA84" modified="2020-08-12" version="1">MKIHPEVRWIYSGREVYGELVDEGNPDAPPRRQRKPAAPSSTEVINHATVTAITDEEKAILDQVEREHALPETSVRLGRVLCHRLGIDTVATLRNILQDVLDERGRNATEVSAAEEDNSTEVPAPARRSERTSVPARKRGKARKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W7K7</accession>
    <name>A0A6G0W7K7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TRP C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_018633</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000345">
        <property type="protein sequence ID" value="KAF0722153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W7K7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014718"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010308">
        <property type="entry name" value="TRP_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06011">
        <property type="entry name" value="TRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026153370" description="TRP C-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="814"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="859"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="892"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="945"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="968"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1030"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="domain" description="TRP C-terminal" evidence="4">
        <location>
            <begin position="770"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1077"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="325"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="403"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="588"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="651"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1097"/>
            <end position="1111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0722153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1111" mass="111268" checksum="D8946C000175CD50" modified="2020-08-12" version="1">MLGLVVMTALLAASTCTAQTPAPVPTPAASTPRPTFTTTSIPRPTPAPTPTPAAITPTSAPIPTPAASVPIPTLTTVTATPNTTTATTPTPKSTQTPSDGSGSGSGGAPPSDGSGSGSGGPPPPTTATPTTAKPTSIPTTTRTSTDPKNTTAAPIPTPAATAPTPTPAATTPTSAPIPTPAASTPRPIPIPASSVPVPTPAASVPVPTPAASVPAPTPAASTPQTTPPSDGTATPLPTSAPNTTSVPTPQPTPNVTVTPTPTAANTTSAPVPTPAASTPRPIPTPAPSVPVPTPAASVPAPTPAASTPQTTPPSDGTATPPPTSAPNTTSVPTPQPTPNVTVTPTPTGVPNTTSIPATTSPQTTPPSDVTAAPVPATTPPKASTATPSPTDATATPSPVPTLSPTDVTATPSPAPTPVTTSTQTPTQTPATTVVVTPVPTSTSSTPSPTTSVPATTSTPSPTETLSPTPTTSTPGATPAVTATPSPTQTQSPASTPVTSSPAATTAPVSSPASTPTDSPVVTPSNSPASTPSIAPTSSSPTDTPSVSPSTSPSTSPTVAPSSSSLSPSATSSSVSPSSVPPSSPSPSPEQSSSAPTSSPDSSDTTNNSQNSASSSNNSQDTSSASTSDSSGSSNPNRPPSTSGSGNGGVASDTTPVSQTSSSVTLGAMLGQDSPGDKATRVVLNTAIAGTMATMLAFHFTSLGTSSAAPSGGGSPASPPNLWEMPVFITFMQNAAIVSMANIDQPYAPFALFTDSFSPLLFLIKGSSSDATTNSTRHLLDEATNSSASNDTSYGIQQYAVRLHIKKSDLFPRAWTFFFIVVAAVLFLVCFAAVIGRLLYGKKPTLAEKATGTSDKLFGVKIWLLTQAVSPLTAISVFEAIDQNTGPKGLGTVSGILALVALVVIGSACIATGVLLSRLPEEKLSKETNQTRFGVLFVNMKFDWRFFYCVTLLVQFATGAVTSGCLSPASQMIALIVIHSLYIVILLVAQPYVTRLQLITTVLVEVDNIAVYALSYGQASAAKDDLHTKKILGYAVMGFIGVLVLLFFARTLLKLVSKFTGKKIKVLEEAEAADSLRDPTVMSPEAFEGQKSSKAHYQKKESPVNRSDDLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W7L4</accession>
    <name>A0A6G0W7L4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RxLR effector protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_017910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000316">
        <property type="protein sequence ID" value="KAF0723106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W7L4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005565"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026306626" description="RxLR effector protein" evidence="2">
        <location>
            <begin position="37"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0723106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="21600" checksum="D932B20D4AAF9738" modified="2020-08-12" version="1">MNARLPLFCHCPNYLRPASAMRLFVTLALATSAVVALNQPRQDSPVLLDHQQIRMDTADNDLRVLQGGRDVKHAKRSLRGQDVPTASYDSSARRLSSAGLFSCCFKGQSSGRAASNNLAAIGRQNSMTESQRRDITIVNQIPLAHRQNRGQGRAQGQAGAAGQGGRRTQRLESMYMSGPLGSPGGSDRYSRQSSSGRSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W9A3</accession>
    <name>A0A6G0W9A3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine-threonine/tyrosine-protein kinase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_017436</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000296">
        <property type="protein sequence ID" value="KAF0723765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W9A3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021785"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="2"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Serine-threonine/tyrosine-protein kinase catalytic" evidence="3">
        <location>
            <begin position="430"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0723765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="522" mass="59705" checksum="61FD2DECC4070BD8" modified="2020-08-12" version="1">MNGWTPLHFASSEGNLDAVKLLMDAGAEPLAKSKVGQTPYDLRNFIVQAVFEKYYPMPTSINAAIKSILQVLAHTKNSSHEIVTTASSILKQALKFPVQRQGVLTTGLMIERIIRDLIRRGSPPHDQASKLLSLLNEMDNYFSATFAVAKSWKLQVNEIRGRPEIQNILITMTHFQDQLIKAVNYHHVNLVVEVMSTYEDLRDEFSTALEKMDNFDKYLDDISNGSMKTLDVLKAIAKDSNIDYIRKYLEVVANDSELSGQDKYTIMSVLLEQELIRYKRNRRLAGLDKSQRKNDIESQATMVLERFEELIEIPNDIGFDFGNKMKNLDVLDEFLKDVSNRSKLRHRIDFNDTANSFQRALVLYNRQIALGNINPMEEFESRAQSCLKHVEELIKTRSNYVPKMSELDLIESLMISSNDLEYNPDDESTLLGIGEYGKVLKGKYRDHVVAVKQCESVSKQIAKGIQTWKTVMNEPYILTLFGVCTELSNPIIITELCQTKSVVTFETDQQRFSSWYINSHWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WBX8</accession>
    <name>A0A6G0WBX8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_017440</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000296">
        <property type="protein sequence ID" value="KAF0723769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WBX8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014333"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126:SF14">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="36"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="69"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="158"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="191"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="224"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="257"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="292"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="325"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0723769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="949" mass="106255" checksum="5DB04117645F7249" modified="2020-08-12" version="1">MSSDGEKLIEAAAHRDVTFAADLLAKRANLNYRNEDNETALYKASEKGNLEVVKLLLFHKAKIETKTCDGKTALSVASANGHLEVVMELLKCGASVDNTDRNGMTPLHAVTSTRQLNIALERREPINSEDKDEIRASYLNVAKELMKFGAKINTKDIDGRTPLHWASKNGYLDFVVELLDNGASVFVRDKDGRAPLNEASVMGHSNIVQVLLKHNAPVNNRSWDGSTALFDALWQGYLDIARQLLAHDASVYVEDLHGITCLHVASISSKGNVDIVKELVTRRAKIDAVDKHGNTPLHCATFWGHYKIVKELITPPALVDKTNKIGCTPLHLALKRGHFDILRLLLDAGANVEIKNEDGQTPPELGNNKVKNIFENHASFSGVLSNQSASELIRQTRVNRKRTSSTVLETAYSVLDLSLVVQSQRQNVLTIGLLVKAIVENVEDDRPEKPYDLGQQLEPLWILITRCWRLDPAARPTASEIVDFLQTHSGDQLTSQEDSSPLPCIEDLEQFQLFNVESNEFVVPEETIKSVTSLEELVKLLLANPATSWPLFRNFILYPDEIKSSNHPTFRAANDRQPQKLLVVKLSYERSDLDSIESCLDDETRCHLVLECVDWGEWNVAGYKCYAIIMERDTKNMSLFSPNRQTQPTALSTQSANCFPPCLWKLQGATTYPLPRGKLSHKMSLRLLFCCEVRDNSSCDYFPHDDVIQVEAQSTFIRDALPTLKMSFLLLKAFALISDYNICIGPDYNFDVRDSAPEEILLTALEAIHGQVDTLQRLNKIVQELESGDLNDDQVENYANEIYGIIDDHRERNASEMLNLLQNAGLNLQSDVISGLKKHALISRYVCKKHSELFEDGVLNLRRDPPLHLDTSSVLSLSLAAKYILKTLENMVESTSEIIVTARGIFDLALKCEVHRQSVLVTALMVERIVRKVQTLEGLEHPQTLLSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WCA7</accession>
    <name>A0A6G0WCA7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Zinc finger CHCC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_017287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000292">
        <property type="protein sequence ID" value="KAF0723907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WCA7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016070"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.40:FF:000001">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.40">
        <property type="entry name" value="q5lls5 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019401">
        <property type="entry name" value="Znf_CHCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13156:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13156">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 13 KD-A SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10276">
        <property type="entry name" value="zf-CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zinc finger CHCC-type" evidence="1">
        <location>
            <begin position="68"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0723907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="111" mass="12523" checksum="AFDA7DF9765358DE" modified="2020-08-12" version="1">MRGYQVLRALRAPMRSAAVIPRSAAFRQQVARFATIYDLKTPYEDINRHRSDAELRIAKVPVVEVDTDVAVCDGGGGALGHPLEYIQLNTVSKEPQTCKYCGLRYKMKHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WD55</accession>
    <name>A0A6G0WD55_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5'-Nucleotidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_016543</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000257">
        <property type="protein sequence ID" value="KAF0724892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WD55"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002781"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF48">
        <property type="entry name" value="5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="4">
        <location>
            <begin position="10"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="5'-Nucleotidase C-terminal" evidence="5">
        <location>
            <begin position="313"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0724892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="492" mass="54764" checksum="12BEF4AC8F002325" modified="2020-08-12" version="1">MDETESATLTFLTVNDVYDVVPNEQGRGGMAELAALIHHEQLLIPPTNHTLVTINGDFLSASQAGEHYKGAHMIDILNNMKFDYAVYGNHEFDFGSDVLVERVKESKFKWFGSNVREKDTGNTLANALDTVILPIGPNGSIKLGMFGVCTQETPQLSFPGDKVIFQDIFETSKRCIEDLKGKGADVIVALTHVSIAHDKLLAKRVPGIDIIIGGHDHEPFTLYQGNTFIHKSGQNAYWLGRLDFDIRKKAATGKVEIFPEWKMISNRNVTPDASIEALVHKYMAPFQTNDLLEQGARQLAVISKPLITRTSVMRSEESNFGNLVADAIRSELGAQYGLINGGFIRGDTVYEAKTQLTVGIVLKEMPFPRPAVLLRIQGRDLREAIEQHLRTYPLLSGSYPHVSGLRVKYDRTKEPPHVSSLQDDQGHDIDLDEYVTVATTKFISQGGDGCVAWKKASLLATDDAIAQVVIRFLEKQRLVSYPEKEFRLQIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WDB3</accession>
    <name>A0A6G0WDB3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_016975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000273">
        <property type="protein sequence ID" value="KAF0724311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WDB3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021491"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0724311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="207" mass="23592" checksum="696ECE9964DEED6F" modified="2020-08-12" version="1">MKATEYDELMAQGKILRSTASRIPTQDSLYSSRLYYLNQALDTFQQALNLSSTETQECLEQIRETQIDLMVLSKLTQNVVATPKQGLREPLRVTVRHRPLLPDDAAPTEKPLPRLNPYDWTERPRICPAPTPKSTSRLHDLYEQKLFPKEPFPLKAASDDSRYDSYRAPLGYLLPPLAPRLRSTDEESMEQMLSIAQTLVSIAQTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WFR4</accession>
    <name>A0A6G0WFR4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cellulose 1,4-beta-cellobiosidase (non-reducing end)</fullName>
            <ecNumber evidence="3">3.2.1.91</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ae201684_016107</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains.</text>
            <dbReference type="EC" id="3.2.1.91"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 7 (cellulase C) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.91" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000243">
        <property type="protein sequence ID" value="KAF0725334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WFR4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014837"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016162">
        <property type="term" value="F:cellulose 1,4-beta-cellobiosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07999">
        <property type="entry name" value="GH7_CBH_EG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.100.10:FF:000001">
        <property type="entry name" value="Glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.100.10">
        <property type="entry name" value="Glycoside hydrolase, family 7, domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001722">
        <property type="entry name" value="Glyco_hydro_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037019">
        <property type="entry name" value="Glyco_hydro_7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753">
        <property type="entry name" value="1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753:SF2">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00840">
        <property type="entry name" value="Glyco_hydro_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00734">
        <property type="entry name" value="GLHYDRLASE7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026155396" description="cellulose 1,4-beta-cellobiosidase (non-reducing end)" evidence="13">
        <location>
            <begin position="17"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="14">
        <location>
            <begin position="488"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="450"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="466"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF0725334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="533" mass="57220" checksum="0A9387E617631422" modified="2020-08-12" version="1">MLRSTLFLLCGVGCHAQYAGSLTLEVHPPLPSQTCTAAGCTTQNTKIVLDSNWRWLHNVGGTVNCYLGNLWNPALCPDPLTCAKNCAMEGADYAGTYGIKTSGSQVSLKFVTRNNVGTRIYLLQDDDKYKIFKLLNQEFTFDVDVSQLPCGLISALYFSQMDQDGGMARFPTNLAGAAYGTGYCDAQCPHDVKFINGEANVNNWTPSKTDPNGGSGQYGSCCAEMDIWESNTISQAYTSHPCTVTEPTRCTSASECGDDATDNRYDGVCDKDGCDFNPWRLNNHNFYGPGSKFAVDSTKPITVVTQFITDDATADGNLVDIKRFYLQNGKVIENIATDWKGINRVSSLTDSMCGQIKTVFDNPDDHAKKGGLKAMGETLKKGVVLAMSLWADHAAHGLWLDSSFPVEKNSSLPGVSRGSCPKDGGVPAELQTLVPNATVTFSNIRVGDLGTTTANSLRSPTPSPPQSSSTPSSSPLSPPPKPSTSGSPGVQIYSQCGGLNYKGPTECQDGLVCIHMSDDFDQCLALASRRPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WGA3</accession>
    <name>A0A6G0WGA3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Transketolase</fullName>
            <ecNumber evidence="4 15">2.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ae201684_015507</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 15">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10508"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <text evidence="15">Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="12">Binds 1 thiamine pyrophosphate per subunit. During the reaction, the substrate forms a covalent intermediate with the cofactor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 15">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the transketolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="4 15"/>
    <dbReference type="EMBL" id="VJMJ01000223">
        <property type="protein sequence ID" value="KAF0726174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WGA3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021366"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07033">
        <property type="entry name" value="TPP_PYR_DXS_TK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000003">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000004">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055152">
        <property type="entry name" value="Transketolase-like_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005478">
        <property type="entry name" value="Transketolase_bac-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049557">
        <property type="entry name" value="Transketolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00232">
        <property type="entry name" value="tktlase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="TRANSKETOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522:SF2">
        <property type="entry name" value="TRANSKETOLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22613">
        <property type="entry name" value="Transketolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 13 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 13 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12 15" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="16">
        <location>
            <begin position="358"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="415"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="121"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="477"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="524"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="14">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="14">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF0726174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="693" mass="75247" checksum="B7A23A5B1D3619A3" modified="2020-08-12" version="1">MAPKQLTPEEETLCINTVRMLGADQPSAGKSGHPGAPMGCAPMAHVLFGKVMNFNPTNPKWSNRDRFVLSNGHACALQYSMLHLTGYDLPIEALKSFRQWGSKCPGHPENFATPGVEVSTGPLGQGLSNAVGLAIAEKHLAATFNKEGHNIVDHYTYVICGDGCMQEGVTSEASSLAGHLGLGKLIVLYDDNLITIDGHTNLSFTEDVAKRYEAYGWHVQTVTDGNYDHEAIHQAVLKAKAVTDKPSLIKIRTTIGLGSKLENTYKVHGSPLTTEDADNVRAKYGLKNEPFYIPDIAREFYDQRSNGSAKEAEWNAKFEAYAAAYPAEAAEYVRRFKGELPANWKAAFPIFTPEDKGLATRQFSEKALNAAASVLPELVGGSADLTPSNLTHLTMTGDFQKDTPIGRYLRFGVREHGMAAISNGLFAHGGVRPFCATFYNFIGYALGAVRVSALSQFGVLYIATHDSIFLGEDGPTHQPIEMNPSLRSMPNMYLYRPADGNEVSGSYIAALENSTQTSVLALTRQGVPNLHGSSPEAVAKGGYVLQHIVNGALDLSFTGRPDLVIVATGSEVSLAIDAAKLLSGVSVRIISMPCRDIFDEQSEVYKRSLFPSGVPTLSVEAASTFGWRDYSHAQFGLDRFGASATIAQLKEHFGFNEQTVAGEAQKLLDYYKGREAPCLFDVPVRRFVKQGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WGT5</accession>
    <name>A0A6G0WGT5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_015380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000218">
        <property type="protein sequence ID" value="KAF0726358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WGT5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002501"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052050">
        <property type="entry name" value="SecEffector_AnkRepeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586:SF3">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0726358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="322" mass="36238" checksum="B5D6E513F6F4A817" modified="2020-08-12" version="1">MACDASSAATASLQVVSNPNLFRCIASFQDGLYLDLLPRYAAWKLAMKVPSASLKFLAPLLITSLTDVRFVLHAAIARCDIACIQRLVQCRPYLVTSEAMDCASRHGYIDLVRHFHNHLFPCSRSAMDIAAKHGHLDVVVFLHENRQEGCTEKAIEGAAEAGHLQVVQYLHAHRFEATTHRAMDYAARNGHFDVVQFLHFNRREGCSSIAMDFAASHGHLAIVEFLHTHRTEGCSTYAMDGAARNGHIDVVRFLFERRTEGCSRKAYLHATIHNPATDLVAMLGRYHHRITPTSLHRAKQSHLVFKRARPRRYFLASVQITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WH13</accession>
    <name>A0A6G0WH13_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_015335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000216">
        <property type="protein sequence ID" value="KAF0726447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WH13"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019083"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006461">
        <property type="entry name" value="PLAC_motif_containing"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01571">
        <property type="entry name" value="A_thal_Cys_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15907">
        <property type="entry name" value="DUF614 FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04749">
        <property type="entry name" value="PLAC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0726447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="177" mass="18859" checksum="BAE4C7D05CCB9D86" modified="2020-08-12" version="1">MGEEYVAAATPGPATPPVEINPLVAEDTTLVVGEWKAGLFSCFDNLLPNCLCSCFCPCITLGQIVARLGVANFIFTAVASCLLCCTVVGSILVFLGIFFFRTKFRKMLRIPGSDLEDCCASFWCSCCVLAQLATHTGSYTPGSCTWKPKDTLPGYSTMLLSNAEPVAVPVAEPPSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WHG1</accession>
    <name>A0A6G0WHG1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">4Fe-4S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_015211</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000213">
        <property type="protein sequence ID" value="KAF0726589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WHG1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004094"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016639">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006005">
        <property type="entry name" value="Glut_synth_ssu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051394">
        <property type="entry name" value="Glutamate_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01317">
        <property type="entry name" value="GOGAT_sm_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43100">
        <property type="entry name" value="GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43100:SF1">
        <property type="entry name" value="GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroprymidine dehydrogenase" evidence="6">
        <location>
            <begin position="46"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="5">
        <location>
            <begin position="172"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0726589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="515" mass="57214" checksum="57E3E970B9C2544F" modified="2020-08-12" version="1">MKIMIRSARRCLSTTATPKIKTGRVERSFIEVSRAPDAYRPATERIQDWHEINTNYRAPEERKAQAGRCMDCGTPFCQSRHLSGCPVANLIPEWNSLVYRDEWREAHLRLSSTNNFPEFTGRVCPAPCEGACVAGLVEQPVTIKNIEYAIVDRAWDEGWITPRIPSHRTGLNVAVVGSGPAGLAAADELNQMGHYVTVYEREDRIGGLLMYGIPNMKLEKATVDRRVQLLREEGITFETNANIGENVREVLADMDAIVLCTGSTIPRFADVPGKELTGVHFAMEFLTSNQKRLLQSKEGSLKSRWNREWINAEGKDVVVIGGGDTGTDCIATALRHRCRSVVNLEHNPSPPETRGPNNPWPEYPKIYGVDYGHAEVRAVFGTDPRVYERSTVAFEGNEEGHVTHVVTARSRLLENGQKEAIPGTEERIPCDLAILAMGFLHPDPQLPQALQLEVDGRKNISTKNFATSMPGVFAAGDCRRGQSLVVWAIHEGRQVAQSVQQYFVSEGLADEEKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WHZ4</accession>
    <name>A0A6G0WHZ4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_015058</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000207">
        <property type="protein sequence ID" value="KAF0726802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WHZ4"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0726802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="78" mass="8435" checksum="D79BCAD4DAEEC500" modified="2020-08-12" version="1">MLRRSSASFDLTLLVTPDEAEDVHVKHRLASETAVPPLAMTLFVETPRPPHNHANGSAVELLARPGCPIASMADCRSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WIG1</accession>
    <name>A0A6G0WIG1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_014867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000203">
        <property type="protein sequence ID" value="KAF0727002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WIG1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007184"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0727002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="128" mass="15968" checksum="68CD304ABBD988F1" modified="2020-08-12" version="1">MALKTNPDDSKRKYYKEWYEKNKEKRKAYNVANKEQVREWHMKNRKRVLEHKRKYREKNRERELLRHKKYFEANRERLLARARLNRELQKLRANDPNAEPPKRRRRFARTPAVPCSTPIQMQMTYILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WIL1</accession>
    <name>A0A6G0WIL1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_014788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000202">
        <property type="protein sequence ID" value="KAF0727049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WIL1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003716"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0727049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="211" mass="23784" checksum="EB07F685A6DA4A8C" modified="2020-08-12" version="1">MTPDASRRYNFRPLATGGVEVNVPANVRPWRALLWSILNVPIVVALPLMIAYGFPAHVLLVFAVPIAFALSVYAGWMAWQLWGIERYIVTPRSWTYEARVLGRIKLASAQYDMVGIQKPRFVVHENPARFGFEGHIAMGHAFVNHREIQTFLQDVEPYVMSYSPLSPGATATATSAMSIDDNMPVLDDMLRAMMPMLDMSARGQFDYIDYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WIL7</accession>
    <name>A0A6G0WIL7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ACB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_014785</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ACBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000202">
        <property type="protein sequence ID" value="KAF0727045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WIL7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003719"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF62">
        <property type="entry name" value="ACYL-COA BINDING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="3">
        <location>
            <begin position="24"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0727045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="306" mass="32943" checksum="96D108B43372DDFE" modified="2020-08-12" version="1">MLGLASLQHGRKWIARVFSSSPAIQALFEEKIALGKTLPKLEDNQTKLEMYALFKQATEGPCTQPKPGMFDFVGKAKWEAWTKLGSLSQDDAKKKYCDFIDALAAKSTTATITTALSTKAAASPLQTTAANGVVKLSWSAAGLDALTVNELSAAFQSAASKSDVKVIVLEPPTAFSSDNESSTKTLVETMAAFPKPIVTIVPAAASGLTVAVVSLSDFVFAHARATFEIPLGSAFPTPDALFNKMRPIHANTLLYLGEKITADTAQRYGLVSRVFTDDFQAQTTIWTERLAQNGHVNGGEWTRHRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WIS0</accession>
    <name>A0A6G0WIS0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_014839</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000202">
        <property type="protein sequence ID" value="KAF0727102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WIS0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004252"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="WW" evidence="3">
        <location>
            <begin position="169"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="3">
        <location>
            <begin position="652"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="4">
        <location>
            <begin position="772"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="209"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="432"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="640"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="948"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="224"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="312"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="432"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="473"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="508"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="531"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0727102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="974" mass="109746" checksum="57EFA0BB4225908C" modified="2020-08-12" version="1">MSESNDDGDADLVVDVLHEGFVKRKSGGGRSLKQCHLRVYADGVVVDLDNEREYELLEVSDWQIDRKNIRQADLSDVGLRVECRGDEDKVVTLWLVLPNEQERGRWRVFLLAALYPQSREGIQVRQLVAQQMQLEKIRQAEQERTRQVISEAKKAKKKKKAEPKIDPNNPWRQYQSDDGQTYYYNMITQESRWTLDDVDIPLRRAYSREVKHDSSLKRQGSRVKPHESEGPVRNEVQEMSRDSEPEIIKEVVDPTLEVFEKSRRMAEGSSAPVADNADPVAETPTEPKRKKKVKSDEKTRQVAEESNVVEEATQKEDVRVQSKEKKQVTFKEDAEEEPPKAKKKAQVANALEMMLGRGPPPAKLSKMESMQAGEDDAPPKHEVHDEEDDLPEHANLTTAERLRLKRQQRQNKMFTAVEEDETDVFLRELAAKKKANESEKVEEKPKDDPFQFPMDEWLDVEQEILFQPSSSEKPLESKDKDDEPAETIKDPPAKPLKKKKSKKVVEQPSPPPHPPAKPAETEEVPPEPAKKPPKKKMIEKKVKKSSKPKPPPPVDILESSESEEAPQVARKIEKKSKDAKPRRMTRSQRKVNILDDSDESPPPAKSKTQAVDFAQPKIAQPEPSQPAAANLQARVDELLQESQSDHSFEKPAPTGPVWSEHVAPDGRVYYYDSTSQKSVWEKPPELIKPEPVAAVKPIFKQTIETEVVAYNPAAHSLLIPPQVKQDLSTCPHCHSVPPTQRCVECESVFCDACCANHHLRYGSMFNHTMALLSVPFCHSCEASSASQTCVECQINLCDACASFLHRKPPKHLHRRVPVQTSTPMISQPVVVKQSVQPVIVQSVQYQAASPIVYQSPMPQSQHQPEFNQPVVMGPQIIHPANTLGNIVTVSQPEAPVTALVLHANQEPRAPVTMPRCVTCRGWGVGLIESNKKQCAHCERMAQFKPTRDLGAIDWDDDSDNKEDAGGSSDSSGWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJ06</accession>
    <name>A0A6G0WJ06_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_014733</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein intermediate chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000200">
        <property type="protein sequence ID" value="KAF0727204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJ06"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000117"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036157">
        <property type="term" value="C:outer dynein arm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036158">
        <property type="term" value="P:outer dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000924">
        <property type="entry name" value="Dynein intermediate chain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF7">
        <property type="entry name" value="DYNEIN AXONEMAL INTERMEDIATE CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0243">Dynein</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="511"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="563"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0727204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="586" mass="66540" checksum="EC4404024368D736" modified="2020-08-12" version="1">MELAYQYTKQRRTFGRHCDFKDVDAKILESIPSTDQYDHDYVKRRPMIGRFDTTPDMSEHEVNTERLITKNSSMRHVEGGWPKDVDSAEQNDVQRFRKKVEKDDEYRQAVKFLGPVAERGLKQNNTINIYQDYFAHMGEPATTEQPSAKGLAVFRDPETVRRTVSKIDWHPESPQRMAACYCILNFQDPKFVNARMPSNSYIWDVMNPNTPEVVLKPLSPLCCLRYNPKSVDQLVGGSYNGLISFFDIRKSGSTPVETSMIEHSHHDPVYDVFWISSKTGNQCCSVSTDGSMLWWDIRHLAQPTHRILLSDKDGQVLGGSSMEYNTEAGPTKYLVGTEQGIVLSVNLRNIKQNNGIVVYDTGAGKHHGPIYTIQRNPCHNKFFMTIGDWTARVWCEDLKTPIMSTTYHESYVTAGCWSPTRAGVFFVTRMDGVVDVWDFFYRQNVAAYSHKVGDVPLSSISVQGNSQSGGKLVAVGDSNGMISLLEVSDGLAIPQSNEKAAINGMFERETKREKNLEAREKEQKRKKATMEEGKVDELPSTKDEKMEELLRTVDANFLNMIKEAEDTENKNMEHKTDSMKPGDDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJF3</accession>
    <name>A0A6G0WJF3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_014621</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000198">
        <property type="protein sequence ID" value="KAF0727362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJF3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021847"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146:SF3">
        <property type="entry name" value="EAMA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="256"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0727362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="384" mass="42499" checksum="FE75AACBCE912E96" modified="2020-08-12" version="1">MSARTYGAIAFVAALVFGTSTTLTSKFVYSIKSQGVEGEPKTFEKPLMQTFLMFVAMSLALIVHGIKQLLVSKDKRHALNWTATLKLCIPAMADLVATALNSVALLYVSVSFYQLSRCTIIIYVATLKVIFMNFVMTGYMRFGIFIQSMAIVLISASCLASAVNLTDTLIGVGVLLLACLTSAAQYVLEEIFMKKNSSKLASADPPNPPLVVIGMEGIWGSLLMLVVVIPLAYVLPGSDNGHIEDFLDSIEMMKNSATLCYYCLLYVISITGFNVASIYVTFFLDSVWRSILVNFRPVAVWVTSLLFFYVFTKGTYGEAWTYWSWMQFGGMLLLFFGTAVYNENVKLSCFTYPVKEDKKEELEKTGVASDESESDHDVKQTTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJU6</accession>
    <name>A0A6G0WJU6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_014520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000194">
        <property type="protein sequence ID" value="KAF0727499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJU6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001693"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370">
        <property type="entry name" value="RNA METHYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370:SF3">
        <property type="entry name" value="TRNA (GUANINE(10)-N2)-METHYLTRANSFERASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="453"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0727499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="503" mass="56054" checksum="9C986B664D42E0A2" modified="2020-08-12" version="1">MEDPVQVGRFFFVDFRTEVAAKCIVSRCVLLQACFRIVDDMQLGTMNMLAKYFLKTYPDCFLPGKADNLVDVKALNKRLRIPKEREALIGQFTRLDIEAFCKVHNSIDQVSLLVGKNMCCMGFLVAQGLSPSSGSCNGRVGGGIAAKFSLRDRPYTGVTTMDPELALVMANAARVKKRDIVLDPFAGSCGVLLACSYFGMGMGFAQDISQSTLRGEGPGRDIAANFDAFHFYRPEIALADVTNPMWRKTWEIDAIVCDPPYGVRTFGSHTDEIFGFDDQYISELIVKWSPYLVKGGRIVFYACGLPNHYEILKSYLNNLTCAYNLEVVSIIESVVHLENTESNTKWSRSLVTLEKTGAFISIPLHELKTIKVHQSSSRQKPWNIERNMDPFDVWRAAWLGDLSSIKEYASRGGDLNLQDVAGKTALFFAAGYNQLETVKFLATKVPIDTMDIQGMTPLFQAARHGNPEIMEVLLSLGADPCTMNSKRLFPAYYAATYGHSEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WKP6</accession>
    <name>A0A6G0WKP6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_014168</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000187">
        <property type="protein sequence ID" value="KAF0727826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WKP6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000351"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007787"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021447"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="5">
        <location>
            <begin position="340"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="4">
        <location>
            <begin position="636"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="790"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="853"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="798"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0727826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="901" mass="101493" checksum="3B2FA12C5F9CABA3" modified="2020-08-12" version="1">MRASIPDYNKLIDPLRRLLDVAVKAAGSSKKKALARAPLSLVGWSQDHAACFEDVKSALANVVPLSHPRSEMEVCVFTDASDKFWGAVATQIPSEDLSLPLEDQRHEPLAFLSGTFTGASQRWPIVEKEAGTSRWFPFVHGPPEPSLHVQPTWVEQRRGQVSGRQAATMGLVMSTFPYTIECLPGDTNVWGDLLSRWGSAQSSRTIARVRKLLHVVSPLQQNDFEWPTAKPILEAQKLAIERGGSTQPGVAWSNEDSFHMDDQGRIWVPDDAVDLQQRLCVIAHQGAAGHRRVAATVKSVSDKFWWATLAQDVETFVKACLHCMQVDGDVVHRPLGSAMHAEKPNELIHFDWLSMPMSTSGLKHVLVIKDDMSGFVHLFPAESADATSTATALMGWFTLYGCVEKWVTDGGSHFKNEVVEKIRKMVGVHHHITTAYSPWANGTVEVVNRLILRVVRALLSEMKLKTNEWPHVLLLVQGALNHQPSPRFGGVAPVTAFTGLPAKTPMSGFVHPTTKEVYVIDGLDDVRQRHMAELAVALNELHRDVVTKSDKLRKQARKRRDEKASVKLTNFSLSLVWRGPEQVTRVVTDYVMETQQLVPPYGVSLHHACRMKMYAEAGREVTEDLLEHIAFGDGGFHVERLDGVRVQDGRYEVLVKWLGLEDEESSWEPAQNLLDDIPVVFVMWCESHRHDEAVSDMMDSLANIRRRCRSAIHVKHIAWTEDLDVSLLREVTRVEPFAADHVDLLPRWKLVANAFAADEAQRSSSGTEEYVTEKVQLLQDIVMRIDEVNNSKKRKQAREKTRKDLLEPTGERLCQEAETRVAKRARITPENANDANSESAINDLLELEKKRHEDEHEYRMERLKLDKEEQQLRRSQAAQMESIVNLLAQIVSRQQNNNSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WKU7</accession>
    <name>A0A6G0WKU7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphatidylinositol transfer protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_014210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000187">
        <property type="protein sequence ID" value="KAF0727871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WKU7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010991"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005548">
        <property type="term" value="F:phospholipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001666">
        <property type="entry name" value="PI_transfer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055261">
        <property type="entry name" value="PI_transfer_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10658">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10658:SF11">
        <property type="entry name" value="VIBRATOR, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02121">
        <property type="entry name" value="IP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidylinositol transfer protein N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0727871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="187" mass="21496" checksum="07D0C55488F5A7E9" modified="2020-08-12" version="1">MLIHEFRILLNMDVHEFQIAELYVVLDSKNDRSRGTQSIEVLKNEPYDNTQGQLGDISPLSKCRIPRNKGQYTLKKYLLAEVPLYLAALFPKGSLTIVEEAWNAFPTCFTYITSTYFLKHKFFIACESAYLRGNCTEENALHLSQEDLKRRSVQVIRIENDLPTKQPSTPSHVHPSTYKCPKTGRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WL65</accession>
    <name>A0A6G0WL65_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_014046</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000183">
        <property type="protein sequence ID" value="KAF0728039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WL65"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021375"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0728039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="112" mass="13356" checksum="73789DBCBA1D3C57" modified="2020-08-12" version="1">MPSVETKARSAYIAAMRDFTVVNRQLIQLHYQSQTWACSHRDFDLFDPIWVQFHEDLHKTDKKLQTLEERMSVAHVKWLKAYKATKTKRDAEKPVEWLSKCWQSLFASKKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WLH5</accession>
    <name>A0A6G0WLH5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Farnesyl pyrophosphate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_013973</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Pheromone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000181">
        <property type="protein sequence ID" value="KAF0728147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WLH5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018809"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004337">
        <property type="term" value="F:(2E,6E)-farnesyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004161">
        <property type="term" value="F:dimethylallyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045337">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042811">
        <property type="term" value="P:pheromone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000021">
        <property type="entry name" value="Farnesyl pyrophosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039702">
        <property type="entry name" value="FPS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525:SF0">
        <property type="entry name" value="FARNESYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525">
        <property type="entry name" value="FARNESYL-PYROPHOSPHATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01017">
        <property type="entry name" value="Polyprenyl_Transferase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0728147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="40573" checksum="4249F7DC47C84DC5" modified="2020-08-12" version="1">MATNTRTKEQEIQEFVAVCHELKEEILEMMTKKYSMPTEAVEWVKEVIEYNCVGGKMNRGISVIHCAEALTQGKGLTPEARKKASILGWCIEWLQAFFLVADDVMDDSITRRGQPCWFRVPKVKQIAINDSFLLESFVYSILRTHFRSESYYLDLVELFQEVIMQTEFGQLLDLTSQPLDAPIDLDRFTIERHQKIVVFKTAYYTFYLSAASAMHLSGVTDPACYAQCQDICVKIGEYFQVQDDYLDCYADPEVLGKIGTDIQDNKCSWLIVQALSRATPEQRATLKEHYGKHSAESIQIIKDLYAVLDLEAVYHKYENDSYEELCKLIDGVTNMPTTVYHMLLSKIYKRKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WMS1</accession>
    <name>A0A6G0WMS1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_013606</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000175">
        <property type="protein sequence ID" value="KAF0728647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WMS1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002191"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052751">
        <property type="term" value="F:GDP-mannose hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055295">
        <property type="entry name" value="NUDT22/NUDT9-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31835">
        <property type="entry name" value="URIDINE DIPHOSPHATE GLUCOSE PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31835:SF1">
        <property type="entry name" value="URIDINE DIPHOSPHATE GLUCOSE PYROPHOSPHATASE NUDT22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="5">
        <location>
            <begin position="117"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0728647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="287" mass="31317" checksum="29FC686584AB1DA6" modified="2020-08-12" version="1">MRRRCVSFVGATSGAAFSCSQVAIALSSVHNRSVHPSAELERNIEDVWAGKLEKNPHLFNGTKFRLASMQVAPHALHMQWGLTDYKTYIGLCSRCEVVEKLKADGASERQDHTVYLSNKIGVAAALVTSDNKVCFLKRSQNVGAYPNMMDVPGGHPEPQALGVGWENMPSESDDALNARCVDELFDSIVNEIHEEVNVPKTALASPLLLGVTLQGEAETPSFAFLTRTTLPADEISALYKQGPLDQFETTQLVFQPLENVTSRSIELTPSAAGCIQLLQEYCEHNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WMT2</accession>
    <name>A0A6G0WMT2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_013597</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000175">
        <property type="protein sequence ID" value="KAF0728638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WMT2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005775"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF20">
        <property type="entry name" value="REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0728638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="389" mass="45391" checksum="44748A38F603170A" modified="2020-08-12" version="1">MDKQYILGIDLSRAFDTVDRSKLMSVLTPILTNDELRLTRNLLSTTSLSLRPSAQPKQSFPTNIGVPQGDALSPVLFIVYLEATLRDVSASPHLPPNLLSRTIAYADDADFICTNPTEMELIIQHAPPILRTWSLEMNIEKTEYSTLQRQPLTPTDTTDVTSWRNCKKLGSLLDDSNDLKRRFTLARSAFHRMWRLWFRRDLIAETTRLRLYNCYVLPVLTYNCGTWALTQSQLLTLESFHRRQLRALLGIFYPNHISNEALFTRCNCEPLRYTLIRARWTLFGHILRRPPDIPANVHMLNYFTAIHIPKWRGGPHITLPVILDRDLSPLQHFLRVRTAEDITNVRRYANDKERWRTLTNLIFEHCPPPPHRRQDNEHVPRMRTRPRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WNP2</accession>
    <name>A0A6G0WNP2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Polycystin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_013268</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000170">
        <property type="protein sequence ID" value="KAF0728967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WNP2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013842"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0728967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="269" mass="30972" checksum="A3A812D1CECC7752" modified="2020-08-12" version="1">MIPLEIIESISGRLYLMFTLVLSSYYLQVLTPSMTNDLWWSGFNASGIQSYLIDVYNTQLNLNGNQTLSLDLTDNKYALGKDYTQFYTPIEISPVYPRMIFSIVAYDLAKSIVAIRQISGPDSIVTQFCWIDFNRTWEVAHTVTRQNRCKARYADNGAVYYEPFARLVDWNKWTESYGVAFNTTIGNALRKTRAGQDWLAQTPYSFVNVDAEVEFWRRHGITQYTFQYSNNFEWGELETISLKNAFGTTQAITIKSLAYLNRIGSETKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WNT2</accession>
    <name>A0A6G0WNT2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Gamma-soluble NSF attachment protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">N-ethylmaleimide-sensitive factor attachment protein gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_013317</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000170">
        <property type="protein sequence ID" value="KAF0729018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WNT2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012980"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005483">
        <property type="term" value="F:soluble NSF attachment protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000744">
        <property type="entry name" value="NSF_attach"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768:SF2">
        <property type="entry name" value="GAMMA-SOLUBLE NSF ATTACHMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768">
        <property type="entry name" value="SOLUBLE NSF ATTACHMENT PROTEIN SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14938">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="282"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0729018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="355" mass="39083" checksum="DF54C750444E42DE" modified="2020-08-12" version="1">MAKKLQEAEENLAKADKLMKTSVFRWSPDYMSAAPYLEKAAECFRAAQDYARASTTFVRLAEVQHKNQASFRAAMHMETAAKLHLQYAPKKPVAAMQYYQTASGYYAETGELGKAAEMLMKGASALEEVGYTDVKQMYLDACELMEAQDKPHFAVDVFRKTAAFLVKRKEYDEAIANYNKQITFFQAIQQPDNMYKAFTSIVVLHLAKPDVVAADQAYMQHLQDDGYLHADECALSEDLIGAFKRGDEDALKALLKKPNWQYLDAPIGRLARTLTMYSTARVSKPARPAAPPSQPAPKSAPEPVPAPVPAAMAAPVEPKHVSEPVVAPAVVPVPAPTPIEVAAPVVSEEPEFDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WPI6</accession>
    <name>A0A6G0WPI6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mis18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_013026</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000166">
        <property type="protein sequence ID" value="KAF0729279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WPI6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014979"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034752">
        <property type="entry name" value="Mis18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004910">
        <property type="entry name" value="Yippee/Mis18/Cereblon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16431">
        <property type="entry name" value="NEUROGENIC PROTEIN MASTERMIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16431:SF1">
        <property type="entry name" value="NEUROGENIC PROTEIN MASTERMIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03226">
        <property type="entry name" value="Yippee-Mis18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51793">
        <property type="entry name" value="MIS18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="10" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Mis18" evidence="12">
        <location>
            <begin position="10"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="160"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0729279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="188" mass="21406" checksum="1A1A8BE46AB4FD50" modified="2020-08-12" version="1">MAEEASDVPVVVFQCKTCSAIVGDSMNILHLSEPNRTVTLQCVINVNRSAVPIYSTQGDDAGNTYHELMCRQCKRILGRWYSATLPQFDAYRMAYTLNADDVVEYHVGMTTPVEEWRMDGALAVADWMNKMETVDDLSKRMEKVRKVLLVVEERLVESKRRVDQKKRAKKKLKLSSPKKPVQPGRPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WQ87</accession>
    <name>A0A6G0WQ87_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_012806</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000163">
        <property type="protein sequence ID" value="KAF0729538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WQ87"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003417"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0729538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="297" mass="33357" checksum="C806F91B168AECC9" modified="2020-08-12" version="1">MDDRRSMWSSPVLRQLILGCYDTTSTLSCLRGHRELMQLVVAKIIQAWEAHIDQRAGGLMQLGPCMYGSYGLPKELQGTIPKRAIFPAPWNEEESFYVNMMPFIMGDMSSLPPSCQRYSSMIQACLETNNGDEIGRVGYLTIYEGVVEAGACQGPSGLRVELVSGGHCGRTKDSQMRALGFEPYRIYGGTYMASNAILSCRVYNSMIKNAHEVAGHLGDVEHLRWILDKHGEKRYLHHELFWIPAGIPYESVPLQMTQHRQYFRLVTSSLTHWNADHSTPNPLGIQPAAQIVHGEQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WQN6</accession>
    <name>A0A6G0WQN6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_012757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000162">
        <property type="protein sequence ID" value="KAF0729697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WQN6"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0729697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="172" mass="16014" checksum="20C710E94C37A838" modified="2020-08-12" version="1">MMGGNGMAQPGVNGATNGDVNGAVNPVPTPAQSVPVNGGQTNGAGDPTNGGVANGAALNGQGGAMNGVGGSNMLMNGQGGGMNGMMANVGGGNMMGANGGGLNPSGNAMMGQEAANATTTATPNVTSTLVPITTPKPATVVPATTAVARSGGATTATGRLALAILLLVAATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WR41</accession>
    <name>A0A6G0WR41_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_012562</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000159">
        <property type="protein sequence ID" value="KAF0729923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WR41"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002611"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF214">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="70"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0729923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="340" mass="38730" checksum="7F82B7431DF20C3A" modified="2020-08-12" version="1">MGLCTSIEAIPVQPPRPVVPQRPQRPERPQRETKHHQSHVTQQHDPSIDWSRFRALVPLRQEFFIRPQDIEFVRRLPSAMNITCLVHVHGEAVVLKAVPQDGRDTRAAMQSLVAEIKNMSRIHHPNIVDFRGFTFMKSLGLCAAFESMQTKSLWDVLSHPKLTARLSWPKQKIQYAIDVCRALDYMHSLRPKLIHRNVKASKVRLNHGFRVAKLSGFDLARDQTFEKTMTKAGLGDIQWSAPELLIDGDYSELVDIYAFGVLLVELDTCEVPLKAAIRRMSDVELHTALKTGRLRPAPSSSCPPEVAKVIKHCLQFDPRNRPSSSRLLRMLLAVQTNLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WR56</accession>
    <name>A0A6G0WR56_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_012526</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000159">
        <property type="protein sequence ID" value="KAF0729885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WR56"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003456"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF214">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026133287" description="Protein kinase domain-containing protein" evidence="7">
        <location>
            <begin position="21"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="474"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="369"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="382"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="502"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0729885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="745" mass="82561" checksum="8F602E8BA2032F19" modified="2020-08-12" version="1">MRHYAPLFLLLAVFTAVVTPWKMQTVRTVQARVQNSPPVWNVTMGRWVGNFVGSDPYISPMDSMTTASVEGALLYIQQKLGNDDPNCTRAKNMSSIWIYEIEIVQPPASVAVYGSISAQVPEYGLFVDMTSGSCATPVGIPDECSELANLTDAYYGQYVGARIERSSDYGDYNDTVWFSYPNSCVLQKYANKTAECRAAQPGGLCPLGVAPDGINCIFNYTILGHIALDDLVGITNMTFKNDSTRYYKDRTEFCLDGRIEFRLKNGGTSAKSDVEFWKDELNRTANAIRSRKLMDYYNNYRNMSNMKALPTVDTLRAQNPPCYVNSPRCANTKYGCMRNLLAQVCQVCTFPNDPSCVLKPSDLSLDFPTLDSPISSPVPKTTLPPSPSPTPTPTSASLQAGPIVGMSTGGLVVIGIVLFVLRRRSRKRWDANTGTATLCKCTEQTMYVAESLDDGDDDVNMEDFKVLRLDESKLTVSYLIGTGAYSGVWHGSYNGHLVAVKKLHPNKITHRQIQSFVYEIVLVSGFDSPYIVQCLGATWSNQLQNLTCVLEYMDSGDLRTVLSRSTPETLPWKDKLSYMTHMIGGLCYLHGRNVIHRDFKSRNLLVDSQKGLKLSDFGTSREDAEASMTVGVGTFRWMAPEVIRGHHYSIAADIYSFGMTLVELDTHNLPYQNMKNPSTGLAMTDTAILLAVGQGAVQPSFPQTCPPWIRDLVLGCIAYNPDDRLTATQVFDIIQAQVQGREKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WRB3</accession>
    <name>A0A6G0WRB3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_012596</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000159">
        <property type="protein sequence ID" value="KAF0729957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WRB3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009837"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0729957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="402" mass="44432" checksum="C7564766DFB69A6D" modified="2020-08-12" version="1">MVDAATSLFGCVELMRQVIRFQDGLPGVLLPLASCIRCSICTQFDFVTDESHMHRSIHDDPAMRMWSSTSLQHMKHNMPRFLSNNGYESLTILLLYKPSLVNCLTSYAASDTAQFELLQCLVNSAPSSITTQTPPYEPMHPLILASKVGFVDAISFLLDSGVIGSTAAMDVAAQAGQMSSITCLQRYMLGCSSAALHSAVENGHWAVARHLMNELLDPWTALWHAVENDLYDLDRMPILESVVVEGPLWIDVKAIRGSAKYLRVALSDAPSKLVCRLNGVMLPLLPVDSLALLLRRTALPYRLDVIDMAVLHREQCWIHDLVHGMKADAFWTDCDEFDIVVPLQMPCRRARSSSSRSNASARGLDVISTRLVRKGMAASIDVETDDMDDEAWGLLAPQLKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WRB4</accession>
    <name>A0A6G0WRB4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_012606</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000159">
        <property type="protein sequence ID" value="KAF0729968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WRB4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009847"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052050">
        <property type="entry name" value="SecEffector_AnkRepeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586:SF3">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0729968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="282" mass="31305" checksum="8D134DF00AC698A6" modified="2020-08-12" version="1">MDAAAGNGHLDVVKYLHQHNLVGASVRAMNYAAANGHLHVVQWLHAHRREGCTHEAVDGAATNNHMEVVQWLMTHRSEKCSTVAIDGAARRGHLEMVQWLHRHSDAGCTIAAVDCAAEHNHVAVVQWLLHNRREGCSTRAMDFMAKYGHLHMVKWLHANRREGCSTRAMDFAAAGGFVDVVAWLHTHRSEGCTVEILEQSAQAGRKDVVEWLLANRLEGCPRCASRVARLHGHYGVARILAQANTDGRWCRVCIGSNNPRRRQQVEQCGDTWPGGPYCACLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WST6</accession>
    <name>A0A6G0WST6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_011973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000153">
        <property type="protein sequence ID" value="KAF0730551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WST6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017996"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0730551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="89" mass="10118" checksum="73B8A3FFB4897EE5" modified="2020-08-12" version="1">MLRRNNACLNLAALDREYEEASDSTLSMVPPKKRMSDPSLTSHDSNPRELKYVAPTNMKRTAPMAIPDTKPRPLHPCFSQDATSRRNYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WSU3</accession>
    <name>A0A6G0WSU3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PB1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_011935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000153">
        <property type="protein sequence ID" value="KAF0730512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WSU3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015879"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0730512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="31869" checksum="E239660312110EEA" modified="2020-08-12" version="1">MQTALKIGFRGEIHRIGVDLTSFGLPNLHAVFENTFGVLPGTYVVQYKDVDSNVVNVVTTEDFDTACCILLTMNESSSAKTLRFFAVLISKQTSIFDKVSTTVRQALDSIHNSKPSEQRSEDQTGATLTDTIHQTSASLGHTLQETLQKTVDGSKVVLDQAKKSWHDVELEHTLKQAAENIKVAAAGVSMYTQELVENIQKLHIAKPSTAPAPEPSPAPPITVPAPTPPAIQSEPTISPSEQAEPAQRTANETTKWAAELEIIHEIVPDADPTIVVALLETSKGDIQVVLDALTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WT37</accession>
    <name>A0A6G0WT37_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Solute carrier family 40 member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_012021</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in iron transport and iron homeostasis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000153">
        <property type="protein sequence ID" value="KAF0730602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WT37"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007345"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005381">
        <property type="term" value="F:iron ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009716">
        <property type="entry name" value="Ferroportin-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11660">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 40 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11660:SF57">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 40 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06963">
        <property type="entry name" value="FPN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026200392" description="Solute carrier family 40 member" evidence="8">
        <location>
            <begin position="27"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="491"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0730602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="526" mass="57787" checksum="4BC4E43BF19AA02D" modified="2020-08-12" version="1">MDRTVITSVVIGAACLVLCAVGAGCAVSECPVDSAFVIPMMVVGVASLVPVIAIWIAAFVDSRRSTKTIDEQVPLVAASAAARIPVYMYASHFMSSWGDRMWQFAMPLLFMEIFVDTLLPSALFSLIVYVVGVLAVPSVGAWIDHTNRLRVMRVSILVENGCIILSTVALGCILFVLSSQTATDERWSWPMLSLFGVVVVAGAIGQTYTDAQTLSIEQDWVVVVARATRTSLGTWNTTLRRIDLICKLISPPVFGLIMDFAGSDPMIRAATGAAVVGVWNLLSAPLEYCMRVDTYLLVPELHEQPSQAKKKPSVNCSQYLASWKEYYDHRTFLVSISFCALYMSVLTGGALNIAYLQWRGVPQAILGLSSGLGGLFGLLGTVVFPIMVSCLGSIERVSLWSVWLFWLTLVPVWVACVWYGESPFTDYIMMAAVLLSRVWLWACDLAETQIMQEYVEPDRRGAINSMQNATSKLFFIAMLLVGVFFSDPREFVALVTVSVGAVLLASIGFSVWYTRYVLVNVRQSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WU38</accession>
    <name>A0A6G0WU38_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_011595</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000147">
        <property type="protein sequence ID" value="KAF0731046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WU38"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018486"/>
    <dbReference type="OrthoDB" id="123866at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="3">
        <location>
            <begin position="387"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0731046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="426" mass="46987" checksum="9DF23377BC7A6D0A" modified="2020-08-12" version="1">MPPQPPTPSVLTPPKPIELLDELLGSVLLLASLVYLLLVELTRRRVLSLHQFTFCLASVGAIATLGGFLEHNVPNEMLELSLFGQLTQTSSIFQLRYAPLVVAFTATIVFIVYISSCGCHCCCLLGGPDGSLHQLCYVHRFRSAVSVYSLACFVLFIVLGMRLNARMRLSAIKPVGGSLHWQLLQSPLCLGAIHTCSLLLVLLKDILYHADTCKDAAETKSPPLPPQTGASVSPTKLVQPALLRPRSTSRDPVMMQAIKQDALAQSLHSIQRSRRPFSASSDEGSLDSRPHSASTESEPILPRSTQIHRISPVRRRAVSEAEAPLPPRRRAQPIQRTPSRTEGDISNLISSESESDEDVIVPSAIRQFTSEYAAVNRLVLTRRPSKPEDADPWTLCVDEKSGASYYYNHETGESAWERPVEHTKWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WUA3</accession>
    <name>A0A6G0WUA3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_011642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000147">
        <property type="protein sequence ID" value="KAF0731097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WUA3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000618"/>
    <dbReference type="OrthoDB" id="75216at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026129409" evidence="1">
        <location>
            <begin position="17"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0731097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="251" mass="27785" checksum="5E3128750AC9F61F" modified="2020-08-12" version="1">MIRAATLLAFAVVAQSASYPEPAPPVYKTPAPVYKNPPPVYNTPAPVYDAPTPPPTYATPAPTEYVPPATPPPPFVPPSEDSYGPAPEPACTSTWKPNSAKYLAYVCSSLYASASKWATNNCKAYYDVTADYDDKALYQAHLCTYWSQRSVFRVVTSCFIEAHLRNEFITKYGKDGPGKWFCKYSDFVNQVNDCYKDSLHYYPLGKDLNSLEQTVAALNPVSSDLPPFKFTGASVAMCAYYNKDQVYNKPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WUB7</accession>
    <name>A0A6G0WUB7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RuvB-like helicase</fullName>
            <ecNumber evidence="8">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_011669</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the RuvB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="8"/>
    <dbReference type="EMBL" id="VJMJ01000147">
        <property type="protein sequence ID" value="KAF0731126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WUB7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009612"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000010">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000001">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="62"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0731126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="454" mass="49697" checksum="02581A2055D43C39" modified="2020-08-12" version="1">MKIEEVVSTMKTQRVAVHTHVKGLGLDVDGSALPIGSGLVGQEKAREAAGIVVELIKSKKMAGRALLLAGAPGTGKTALALGVSQELGPKVPFCPMVGSEVYSSEVKKTEILMENFRRAIGLRIKENKEVYEGEVTEITPEETENPLGGYGKTISHVILGLKTTKGTKQLRLDPSIYEGLQKEKVSCGDVIYIEANSGSVKRVGRSDAYATEYDLEADEYVPMPKGDVHKKKEIIQDVTLHDLDVANAKPQGGQDIMSMMGNLMKSKKTEITEKLRSEINKVVNRYIDQGVAELIPGVLFVDEVHMLDIECFTYLNRALESTLAPIVIFATNRGVCTVRGTEISSPHGIPLDLLDRMLIIRTMPYSVEEMVQIINIRAEAEGINLHEEALTRMGEIGSQTSLRYAVQLLTPARIMAETQGRSDIVVDDVDEINDLFNDAKRSAKALAESDGYLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WUM4</accession>
    <name>A0A6G0WUM4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_011472</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000146">
        <property type="protein sequence ID" value="KAF0731211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WUM4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009812"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00177">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051213">
        <property type="entry name" value="START_lipid_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308">
        <property type="entry name" value="PHOSPHATIDYLCHOLINE TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308:SF56">
        <property type="entry name" value="START DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00234">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="2"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="START" evidence="5">
        <location>
            <begin position="338"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="548"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0731211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="892" mass="97518" checksum="CFF281C96AE4344C" modified="2020-08-12" version="1">MATPHAGYLLKRSKPNEWKTRYVVIDNGVLFYYKHKRDCNPKGVILLSGCSVSATPDQPGCSFAISHPSKPSIQIHWSTSEPSVTTEWMQAVATHLTLPADAETPPLPLKEHVVRPPDIPQTWTEPSPVPPQFSGTIDAMVTQMASFVLDHGRWALQTDHATAKSTQLYLCEKTRTAAMSKLSLARPAHEILDVLLDPLQDSSCLVEAIDGHTSLHRLMLKAIFPHHGRDFAVLRHWRTLSDRSILVLTRSQAMSSLYFEAYYIVPNLDNTAAEVTYVIHVDEVLPAAVVVSRAHKLDVLRAKFEPVSPRPLPRMSSCKVDAGVYEIPLQYAAEVDAAIDKLVHAATHADDEWTFHSEKSGVRALSKDSSEMGGGGSLTTVLGIGHLDFPANMVLDFLLATQCKVEYDPMCAQSFQVDALDAHTTIDYYESKPVLIVAGRDFVNLVHWRVLPDNSIVVVAKATTDDRCPVKKWTVRGEIHVAGWRIVPKSTGGVDVAFMVQMDLKGSIPAFVQNRIVVDQAFVILTVASVLRKRPPLAAAPVTNKGKQSTASVKDVPAAVTPRKTTPSDVVKPKKDVALTKSTTRVEAQVQASAPLSDLSFSSLVYFSSVFLAALYIPPVMNLHLTFEILHDIVVWAVVAYVALQVYLGPAHVRPHWHHGQRVHGSLEVDCSNTLQYIASKGDKITMTHVVLRAVAQALKQSQTMNGYVIFGKSYPSATVDVSFLVENDPCRAVKFAASGTASLSKFADELTQQTGQTRLMAVYKSAAAVLPMFVVKCIFKVVFWLSQSLGFGISWLGVKPHMFGQAVIVNSTTEGFGALDTAPGLPAPLLIAIGGVTKKPTVVNDAIEARPVVRLDISIDPRLARASDVAIFSKSLRSYVETPRQLDAPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WVY0</accession>
    <name>A0A6G0WVY0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_011265</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000141">
        <property type="protein sequence ID" value="KAF0731647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WVY0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002411"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="29"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="62"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="190"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0731647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="206" mass="23100" checksum="C9DD2ECB81B04058" modified="2020-08-12" version="1">MHLALRGKHLDVVMYLVDKGVDINAIDKERRTPLHLASNKGYIDVVKHLVNKGADVNITDKFSWSSLHFGAYCSRKDIVMLLLDAGADVNMETNEGEKVCDTCNDENLKAILNLHTVDNIRRCFGKDMVPILASNLKTVPFLANSILYAKMQNIQQNPSNFYRHKKDPRILAAFTELDKVTKSDVDHKSQSTQKDLLATKDSSGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WWB8</accession>
    <name>A0A6G0WWB8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_011115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="VJMJ01000140">
        <property type="protein sequence ID" value="KAF0731817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WWB8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010538"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF1">
        <property type="entry name" value="PROTEIN PHOSPHATASE PTC7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="30"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0731817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="277" mass="29654" checksum="AFC70AFED1D3B03E" modified="2020-08-12" version="1">MHVRVARATPTRRWITSFGQISSFSSWTFSSGLVSLPHPEKKRGEDAAFVTPTAVGVADGVGGWARKGIDSGAYSRTLMAACELSTLTDPVKRLTEAYNTTKVPGSSTACIIQLSDDGTIHTANLGDSGFMLCRENAEEEGWSIIYASPSQCHYFNCPFQLGHGSRDTPAHADLSTLSVEPNDVVLVATDGLFDNLTEEEILSLLAGITEESKAQKHEAEARMQFTASTIVAVAHEIAKSETRLTPFAQAARQAGYKGTAGGKMDDITVVAALIQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WWK8</accession>
    <name>A0A6G0WWK8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_010866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000138">
        <property type="protein sequence ID" value="KAF0731913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WWK8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007557"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="1">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0731913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="815" mass="90105" checksum="0F8AAF2BF50DFC37" modified="2020-08-12" version="1">MPPPHLPALARAQCDVLVAFVNHLVAYKAHKTKLFQYEGKPSERKKLLEMFYNGASPTTAALKHVSSRSMSYVIRHVLSTQYAPLLSYAAFQTLATAVQSPAIVNILQSEINRLPSAHAELLHVLCHLIHTVTKQLMVAEDALITHLGVYFCRPSESPKELQDSLNARKAICRTLLRNLPSLQFTHPMEAPPRRRSTYRPWTLEMAQHMRLLLEAIAASPAKKRDLFLRLTDSSLVSQVVDPSYAGPVDAMSVHTLAGALKLMLQRTDALVGRDVFSFARSSDSPVADLSRAVLALDPTRKRLVLLLWRCIQQALIDGASLELLSSALSGHIFEELKPPRDPSANHMLDRTAIEVLKNLDTLLRLCCPRFRSVALVVLTAQRWLAACRERNADSSQADILDKSFLERTVETTPCRAAVAVDGAAVELRRKSSLETFEESAKHAFLAMENASAIKIDESVAGCTASVDEISWRSDAESSFTSYDSNQSTPSSIMTLCVSSIPSVDKIVPPPRSSSLRVAIDAHDFIFVKPSSIAEHMVACEYASKLMEVHDLDWGYVADMTGYATASACRAVFESLNLPLIASSAVWKLLHEVYCAYMPPSVRRLSWSDALCFCKDCHVDSTVLESKAILTMNDLLFHEFYALVHNVAHAVYAGTPQPMRDLIIYNVVGFAKRSMMEDSDIGISSLEWSPQCSRLVHARLPAFKALCLHFATWKEPRTPQLGPDDIVSMLKALSVVPDMIQPDHVVAFVQSHRGPQMLSGDLFIYKVIELVLSIGTRVLAHPALQALYPSHSDKLLAVLDVWGFGDHAAVSKVVAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WWL4</accession>
    <name>A0A6G0WWL4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Enoyl-[acyl-carrier-protein] reductase (NADH)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_010964</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000139">
        <property type="protein sequence ID" value="KAF0731865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WWL4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013950"/>
    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004318">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.400">
        <property type="entry name" value="Enoyl acyl carrier protein reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014358">
        <property type="entry name" value="Enoyl-ACP_Rdtase_NADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43159">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43159:SF2">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH], CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000094">
        <property type="entry name" value="Enoyl-ACP_rdct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0731865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="263" mass="27331" checksum="34228BE8022B8613" modified="2020-08-12" version="1">MASGLGLAGKKAVVVGLANKHSLAYAIANTLQNHGCEVGLVSAPVSFERAKSSLSLLPRAPIFHVECDVTRPQDLEALGVIASDIQVDCLVHSVAFAPSEALTQPFSKTSTSAYLTAMHVSSMSLLSLLQHVPIQRGGSVVALSYLGAVKAVPNYNCMGPAKAALEATCRQLALELGQDQIRVNAVSAGPLNTLSSRGIPGISKMRQNVARNSPLRRNITPDEVANTTAFLCSDLASGITGQTIYVDGGMSSVAMVEESSSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WWN1</accession>
    <name>A0A6G0WWN1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Brix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_010912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000138">
        <property type="protein sequence ID" value="KAF0731961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WWN1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009342"/>
    <dbReference type="OrthoDB" id="10253204at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10480:FF:000001">
        <property type="entry name" value="IMP4, U3 small nucleolar ribonucleoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF2">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="1">
        <location>
            <begin position="84"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0731961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="287" mass="33338" checksum="395A814C0A1BD4B0" modified="2020-08-12" version="1">MSVRRNVRLRREYLYRKGLEGQERAQYERKMQLKKALENGKAIPTELRGVEDKLRSELEYDDDKHIVPKSHIDDEYQNAGMFDPKIAVTTSRDPSARLKKFAQEVRLIFPNAIRLNRGAHTVGDLVESARANEFTDLVVITETRGEPDGLVVCHLPYGPTAYFSLQNVVMRHDIEDRATISEAYPHIILHQFETTLGQRVGNILKHLFPVPKPDSKRVITFANQDDFLSFRHHVFKKTGREVELLECGPRFELQLYQIKLGTLEQKEAENEWVLRPYMNTAKKRKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WYC1</accession>
    <name>A0A6G0WYC1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_010288</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000130">
        <property type="protein sequence ID" value="KAF0732580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WYC1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015340"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0732580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="101" mass="11999" checksum="319CA117A0955AB8" modified="2020-08-12" version="1">MTIEHCIGMIKSRFSRLRDGFFTIMRDTECHEMVIRMILACIMLHNICISKDDERNEEYDVDTPQIEVHGALEPDHDDDVWTPANEFQLEIQKHLVLRHFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WZ89</accession>
    <name>A0A6G0WZ89_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">phosphoribosylformylglycinamidine cyclo-ligase</fullName>
            <ecNumber evidence="2">6.3.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_010205</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.1" evidence="2"/>
    <dbReference type="EMBL" id="VJMJ01000128">
        <property type="protein sequence ID" value="KAF0732881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WZ89"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018941"/>
    <dbReference type="OrthoDB" id="2018833at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046084">
        <property type="term" value="P:adenine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="entry name" value="PurM-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004733">
        <property type="entry name" value="PurM_cligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520:SF12">
        <property type="entry name" value="TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
        <property type="entry name" value="TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="PurM N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PurM-like N-terminal" evidence="6">
        <location>
            <begin position="45"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="7">
        <location>
            <begin position="179"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0732881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="390" mass="42171" checksum="368493A4C6FA1C50" modified="2020-08-12" version="1">MADSRYNQRGVSAGKEDVHNAIKNVDKGLFPQAFCKIVPDYLSGDDDYCIVMHADGAGTKSALAYMYWKKTGDLSVWKGIAQDALIMNIDDLLCVGATDKILLSSTIGRNKQLVPGEVISAIINGTEELLASLRSQGIGIHSTGGETADVGDLVRTIIVDSTVVCRMKRSDVISNHTIQPGDVIVGLASFGQATYETEYNGGMGSNGLTSARHDVFCHALAKEFPESFDPNVAESLVYSGSKQLTDEVPGAPLNAGKLVLSPTRTYAPIVKAILDKLPRNAIHGMVHCSGGAQTKVLHFVQDVHVIKDNLFDIPPLFALIQQESKTNWKEMYQVFNMGHRLEFYVSPETAASIIEISIAFGVPAQIVGRVEANTGKKVTIVSPHGTFEYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WZP0</accession>
    <name>A0A6G0WZP0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_009862</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000126">
        <property type="protein sequence ID" value="KAF0733037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WZP0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001751"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0733037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="275" mass="31763" checksum="14AFE4FCD159173F" modified="2020-08-12" version="1">MSFWKASVTVLPVLKHVFDYQLDQWKDVATWDVLYSPRNAILYSQDNALYTGMPAFRVKRNQALVHMDKVHLFSIVASAKDQHKAPTWEVASLIGMLYVLNHRRKLWPAKFVQATAWVVIVTFTWKKLSIVNFTKARATLCAFIWAMRYYVYSKTEHGTTQIEWLKGLYLDILGLDQQVWVHNDGLVNTHSQVYPRVALNPKETNDEVSSSSSMVRNASYVSVDLANLGAEDDDIVKGQWHIHRVEKNHLRGPFLDPDAKEMYKHIFKLLQKTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X110</accession>
    <name>A0A6G0X110_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_009769</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000122">
        <property type="protein sequence ID" value="KAF0733535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X110"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016265"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0733535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="164" mass="18536" checksum="9E659D56680AAFA6" modified="2020-08-12" version="1">MVRYAFNKHDAECLGWLFIDDLEKVGHELDDMELFKNVPTWLDEVHKTLTVDADSKFTADDLIAAVRAIPRRHISPEYDIALHTSAALVASIYSSVNLLSDDLTTKPLVPAVFDESSGPEKVLLRPERGDLGKTIYLVASQDSHKSHEHIAWFQLLQSWQHQAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X1K6</accession>
    <name>A0A6G0X1K6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_009314</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000119">
        <property type="protein sequence ID" value="KAF0733743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X1K6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000562"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF15">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0733743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="461" mass="51708" checksum="35881823F7EF371B" modified="2020-08-12" version="1">MVWTCPQHKRTSLSSIPQSIVQHIAFYIPVAKDFLSFLASFPDATSIGDLQHFLELSNILEPNDLWPKLQLQELTPSLVPSVRRITRFFTTIYVLKVFDLELLQQCLHPHNVVELLKCPLSNEDLHEWLTTSVSILPVQHIYVYSSNKVTSARFLDQLGSMAHLVSLSLYGCTLDTCDLDRLFDFIGETSNLTRLSLSALDVSTDIRILSPPVRFGQRHLQALAVWLRRCIVTSITLRDWFVEDEDRASAVELLKTIFASSTLEHVSMDMKSFDRDIQAAMFPAPLRIQSLELSYCSLNVTTMAALATVLRHSNITSLTLDESEIDLTTLQSLLDALFDTNVRQLRLSSTCLKDDACALIAVALPSLKLVELNLTNNMVTDRGVEVLAEVVGCAASLTSLVLSDNDIDLEGATALVKALSERPQVTTRLDLSYNFIYDAAYLDDMVQRTPQILKANFQSYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X2B3</accession>
    <name>A0A6G0X2B3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CHCH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_009213</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000118">
        <property type="protein sequence ID" value="KAF0734040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X2B3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009578"/>
    <dbReference type="OrthoDB" id="1106148at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010625">
        <property type="entry name" value="CHCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055304">
        <property type="entry name" value="CHCHD2/10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13523:SF2">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13523">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 2/NUR77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06747">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHCH" evidence="3">
        <location>
            <begin position="101"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0734040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="143" mass="14387" checksum="F2A3004AB968827B" modified="2020-08-12" version="1">MARSRSSPARRPAPAPAAKPRAAPAPAPVQAAPAPAPVQQQSGGMMSGLIGTVAQGMAFGTGSAIAHRAVGAVANSFGGSSDNAHQEAAPAAAAPVQADVCSNDHKAFMDCLNANQNNVASCQYYFDQYNRCTGQGQASFSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X3I8</accession>
    <name>A0A6G0X3I8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitofilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_008826</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MICOS complex subunit Mic60 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000112">
        <property type="protein sequence ID" value="KAF0734477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X3I8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000524"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019133">
        <property type="entry name" value="MIC60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415:SF7">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415">
        <property type="entry name" value="MITOFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09731">
        <property type="entry name" value="Mitofilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="244"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0734477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="662" mass="72240" checksum="8A1950F92F669743" modified="2020-08-12" version="1">MWRQISAKNSRQALRRYATNSGPTKGAPAAAKPATPTQADLKSLKPESTPLSKKTPEKRGGGGGVYALLFAAVGTTGGLGYYIHENPQFNPAYLKDNEAFTKFREFVLATFPPTKAGWVSSTDIVLSDPKVQKAEKPKVKDVKEIEQSAKKTLEKKAEEPKKAVVQKTDAEAKKVAEPTKADEKKSEVVGKVTEAAEKVVESAKQVVIVVKDEVAAEKAKVEAVVTKAEAAVKAEVAKAEAAVKAEATKAATAIQKKLDDAAAKEKAAIDELNRELETFEEKAKEASAATKNKVVKKARAEAEALSEELDHTILADIKELDAETLRLRVAQLATEMKNRSKWEAVRMLESLKRMEEEVHGQHAELLRQQDIMHKELLARELRLQEEVLTRTARKELDGLREEHDAQLIALVTTQKAQIQAEFDKNLAALKAESEKKIQEQIAQKAREIQAVAQTEQAGRIKELEAIRVELKAVNEMLGRTSDYEAFSHQVHKVSVAALALTNRIEAAAPLHNEIRALRSAGKCDKFIEETIKTLAPLADGAPSVAQLQQRFKQVQKAARQAALVPENSDGLVGHLFANALYFFMIPPGGPIQGDDAEAIFSRADYALRGGDIESALIEMDKLAGLPREVVSDWVAAAKSRLAVEQTAKVVKAHVSLLAASLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X463</accession>
    <name>A0A6G0X463_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Potassium channel tetramerisation-type BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_008591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000106">
        <property type="protein sequence ID" value="KAF0734740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X463"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003510"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18316">
        <property type="entry name" value="BTB_POZ_KCTD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045068">
        <property type="entry name" value="BACURD1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11145">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING ADAPTER FOR CUL3-MEDIATED RHOA DEGRADATION PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11145:SF8">
        <property type="entry name" value="RE57120P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Potassium channel tetramerisation-type BTB" evidence="1">
        <location>
            <begin position="152"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0734740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="256" mass="28949" checksum="63549246CFFCAE9D" modified="2020-08-12" version="1">MERLTLDAVTTFFDRPTVHGFHPFLQVLHVKALADVGDPLCLVVSDGKFYMTCLYKPQKKEESCGIHVHCIVQLIDVVPKFVADQMILVATTIAHIACCPARIGQPIFRELHAPSMCAFLQAQLDLLLFKERVANSFITAVNDNANAATEMVTLNVGGQRFQTAASNLLRHPMSYFTYMLQEPPSDNEYFIDADPIHFDRIMVHLRTGDPLSYDGLSLWETLQLRKTVRYLGLEHHCTSMDIFIEHMNYLTTTTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X4V1</accession>
    <name>A0A6G0X4V1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Potassium channel tetramerisation-type BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_008529</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000103">
        <property type="protein sequence ID" value="KAF0734867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X4V1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010410"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18316">
        <property type="entry name" value="BTB_POZ_KCTD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Potassium channel tetramerisation-type BTB" evidence="2">
        <location>
            <begin position="69"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0734867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="326" mass="36067" checksum="485318BFD3CFC26D" modified="2020-08-12" version="1">MTSMTDRVNQEVLDAALDSVQAMANPNHKVTAAAKAMTEQVAELKATMKEWNEMEHRIQQNIASMRQVVTLDVGGMIFKTSKENLLRDEGSYFHALLGSGLWKPDCGSDAYFLDLPGAHHFHRIMDYLRTGVLSYSGLSEFDVAQLQSNLEYLNLERALAYLPSLWTWELSGNANGLALSPCKRSVTVVKRDVRVSSSIMGNMPRKVFRICLEIGSSNIDIGLASRGSFNANATRHNESFMIDMRSGALFSRGKKLDNARSSMFMAGDHLTVRQADDKIYFEKNDEEIGVITEVDSTLKLFPAATFYASGSKLTIVSSSNNPSPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X517</accession>
    <name>A0A6G0X517_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Elongation factor Tu, chloroplastic</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_008288</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000101">
        <property type="protein sequence ID" value="KAF0735075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X517"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015528"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF9">
        <property type="entry name" value="GTP-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="5">
        <location>
            <begin position="112"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0735075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="540" mass="59442" checksum="7B34A29404899AE6" modified="2020-08-12" version="1">MKCLPAEIEQGNVEYKLQLLNPSADRFQHLVTQLNWRLNEGHGYAYYELGVADDGLVIGMPPEDLEKSLNTLFRMCQVLSAKMHVQSFREGSQPSYKAARVAVSRIAETHAKKQVRVSVIGDVDSGKSTLIGVLTRGCLDDGNGLARMQVFRHLHEIENGRTSSISEQIMGVTKDGKICKFSTLESRNTSSIDAQSTKLIMLSDLAGHQRYLKITASGLTSQFPDYAMLVVDAKSGVQSMTREHLQIVLGLEISVFVVVTKVDMVDAPRISQTLQEISALLASMDVAKTPCYITDASQLETYNSLQDTNVVPIFQVSNVSGANMPLLQQFLASIDPTRSWPSVRNCTSEFHISGHFQSEDVGTIVTGLVKSGTVHVGESLLLGPTNSGSFYGVHVKSIEVQRTPAKSIFAGQTAALLVTSLDNDEIDMTTLRRGMMLVHPSLSPMATRQFDAEVQLLNASVVLKENTQGVIHAGPIQQVAKVVAILDEKSHTVRLRFEFVHSPEYMRPDWPLVFRERHTHAVGKVLQAVYLKPDLVRSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X592</accession>
    <name>A0A6G0X592_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_008338</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000101">
        <property type="protein sequence ID" value="KAF0735126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X592"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001017"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016212">
        <property type="term" value="F:kynurenine-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000024">
        <property type="entry name" value="Kynurenine--oxoglutarate transaminase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051326">
        <property type="entry name" value="Kynurenine-oxoglutarate_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43807">
        <property type="entry name" value="FI04487P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43807:SF20">
        <property type="entry name" value="FI04487P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="47"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0735126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="445" mass="49537" checksum="71A2B7D100CDF4F0" modified="2020-08-12" version="1">MLSTPRLVRQILARGFSTAAVPASPALNLRKNVFAEFSALAMQHQALNLGQGFPSYGTPSFVKEAAIEFIEQEQNQYTRPGGHPQLVKVLADTYSPWYNREINPMTEIVTFTGAQEGIFCIFLSLLSKGDEVLIIEPFFDAYINIALLLGIKTVGVPLELDAETKAKYNDPNNHDTFSSKDLKIDLKKLEASITPKTKMIVLNTPHNPTGKVFSKEELEGILEVLDRHPQIIILSDEVYEFAAFEGTPHERIATYDGMFDRVISLFSAGKTFSCTGWRVGYAILPEKFADLVAKTHSAIPFCSALPFELAVAKGFQAAATNNYFNDLSKLLERKRDTIVDALEKAHLKPIVPDGGYFVCCNVSALDSYEEFKHLETVKDLPADERPDYRMAKKMCVEQGLTVIPTSPFFSKEENQISPALVRIAFCKDDATINKAVELIETFKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X5Q6</accession>
    <name>A0A6G0X5Q6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_008175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000100">
        <property type="protein sequence ID" value="KAF0735259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X5Q6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015500"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="9"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0735259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="246" mass="27892" checksum="6450B0C3A2AF5D0D" modified="2020-08-12" version="1">MLVQPSPLVAMKTSITSVSKSKKGAHLPTQYTISVADKRNNTTQWLVHKRYSDFRAFRTALLDQSTNLCGSCAELADEAPVSKRFPGRKWIFSNNTSVINERKEGLALFLDRVNVAVRNCGDPACAARPLLEHFLMLPDMRYTFIDMQLEEPAEKSPPAKKPEIMFIPPPPSLRHSFAGTTEHSREQVPQLLRHTFHGSQSRSRRHSVHISSSERIKKLREFQATLKPVTKPDRMRMSLETIAEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X6H5</accession>
    <name>A0A6G0X6H5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_008048</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000096">
        <property type="protein sequence ID" value="KAF0735481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X6H5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017038"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641:SF19">
        <property type="entry name" value="NEPHROCYSTIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0735481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="654" mass="76711" checksum="2A01F0C037658D86" modified="2020-08-12" version="1">MPYTAATKQSLVEHVLNEPDGHLYVKPATWFVSHAWSYLYLDVVDALDDFFPENDLEDSVAVWFCTFCNNQHEIESQCYDFDYWFDIFIRSLRSIGNVVMVMSPWNNPTTLTRTWCVFEVYASIVENARFEIAMGRSQKASFLHDIQNDGAFIQMLATIHSEKSQTTIPSDRDNIFKLIRKEVGFQKLDRMVFEALEKWMLRTVEKQIDDAKSLETKAAWLYTKAEMTATKGFLYRATIASYECYDIYRQEKGDNFVGTWKALSQLAMLKMYQGYPFEEVEPMFLNALDHLTELLSRSHEDTLQTMHYMGTFYVYNQKYDLAMPLLKECFELQCQHFGEEHVNTRVTMTSICSTLRCQNQFEEALEWSIRCYDVETRMFGEDYPEAYRTRHEMGLNYQSLGDFARAEVHFDAALQDCRRMYGLDHVKTQNIESSLADIYFLQGRYADAKEIFLQSLRDDSTHIHTKQLYSVKLGLLHLATQDTDRAKECLDEAVAHLRAEGWIMENIYVFLTGLFLLKMKTGQFTLLDEINSFEKDLDDATWSKDVWKDCKCSGCYDEIHGDLYTCSECPPDTLLYCQECVTLKKNEVHCKHSGDRIRSDKPPLRYLQEERLKILAKNSDWDEYERRFLMYEAFCDEQVVPSEARLARYQREGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X7Q5</accession>
    <name>A0A6G0X7Q5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_007694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000091">
        <property type="protein sequence ID" value="KAF0735944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X7Q5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018893"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0735944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="463" mass="53228" checksum="46D93B5C7920D016" modified="2020-08-12" version="1">METTNIDNDLDLLHDLQLLIANDDQLQDDLANVCDLLLDDPSSSVDEDSIATNAVLNPPSTASPEHNHSTTTSATLPPRRQKTKEPRRFEVRQRQEIFLLRHQVEVLKSQLKTHGKRELAPPSKWENIAKTESIEKENALRENERLKEVVHQQATFIEHMEKFCRKRPRLSTHDMQSEEWQSYRLAAQQSLRVAAIHAIADRQLRRMQSTFIKAGVFDATKFILRAEIVPQPGNSGRFECANNIVLDAPFDTIATATWHILATKTPVELPEGVRQVAEVIDDHTIYMMQTDAYRRSYCNTIRKRYIEHDRHVIIQRTVQEDALMPHMNRGAVENKSVWMEFTPLPDDPTKCRLTMILYLELGQLPSKSDPVMEMMESIVERFSIAHRPTIPGTFPPAIFTDIDTTTIPYLHVQSFAEREKLMISAWLTQSILRSKTISVIHLTRAMSCKQLGNNPCTMHHRSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X7Y3</accession>
    <name>A0A6G0X7Y3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hemerythrin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_007208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X7Y3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008013"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.520">
        <property type="entry name" value="nmb1532 protein domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin-like" evidence="1">
        <location>
            <begin position="58"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0736185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="176" mass="20817" checksum="D6486FAD9F150C96" modified="2020-08-12" version="1">MATTKTAQELASKPALERLADLRTIEDELARRTMTAQVYDILLREWKQDRRYRGGAEHLVDEIHLWYRQGFESLAKQARSRRKVDLPSFRRLNGNLHHHHSYEDRAWFPVLKRLHPECRPELKILEKDHRKLVELEAKVEDGDFEAMVEFCDHLVDHLNREEMLSVPWLLEGTGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X871</accession>
    <name>A0A6G0X871_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ae201684_007296</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X871"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008240"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="BCS1 N-terminal" evidence="14">
        <location>
            <begin position="12"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="250"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="444"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="484"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF0736275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="503" mass="56969" checksum="BB76D069F4E2039D" modified="2020-08-12" version="1">MKDSTTFEVRETLSAPSVSNIRSAFDMVTASLPTERVVYEVLPFDPSTMSPNLDAVNSTYLVVPSRDKSYQLILEYVADHLQTKQDHRSFEVDAGKKKLNFWDEDEDHTDDPDNKKTSTLRAGYGAHHFKWNDHQLICLRQQIGQPVGTDREAVRMENVVLLYPKVHAENILHGFVDAVVAAAEATRKGFISIFQWNVDCEYWRDAQKARARPIESVILPRATKAKLIDDLDDFVSDDTKAFYAHHGIPYKRSYLFYGVPGTGKTSLIQAMGGQYERNLYFLQPTHPKMTDDSLRAAIEKVPRKSIIVLEDIDALFDKDRRKKVEQSPLTFSGLLNALDGVGSPDGHIFVLTTNFRDQLDDALIRNGRVDVHVAFEHTTDEQMEAMFVSFYPGEKDGKAFATALTAALGSRKMSMAALQDYFVTQRRKSAAEAIANVGEVVRELDERQKDAEGDDSSSYQLEDTEEEWAESYAPWMRNSLELAKAEEDYDNDTKESETMLTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X8G7</accession>
    <name>A0A6G0X8G7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_007320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X8G7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015207"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0736299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="172" mass="19060" checksum="EB0D99E3B45126B1" modified="2020-08-12" version="1">MWAKKDDNSYECPSGLAIPRKVFHAVRQLYGYMSCNKRRYGILTTFTTTFLLKRDHDGKLYISKGIAANRYDPMTVLEAITRLLLTKKPPADDDLSEAGSSPVKDPYAQEMPKLSKSTGKETKKKSKPPTPKSAELITTPKLIVKKTTESSFLSTTSPITMSLPVVAMPVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X9A2</accession>
    <name>A0A6G0X9A2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_007542</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000089">
        <property type="protein sequence ID" value="KAF0736532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X9A2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006326"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042453">
        <property type="entry name" value="WDR53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44666">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44666:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="222"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0736532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="300" mass="32875" checksum="AC89AEEB8065CC7D" modified="2020-08-12" version="1">MMASGSDDSTCRIWDLRTRRVSQCIAQAFAGDPVQSVTFATASQVYVASRNQVYLFDLRNASSLIVTEATTIFDPVADEINHLHLHPMSTKKPWLAVPDDEGDISILNLKSQSMHTLRGQHTNICSSAVFRPRSAGYDLVSGGLDCQVIFWEVKSDGSGGRMRYKMNMQTLESGLGDDTQMWNPPFVYGLAFSPNGKTFAAALGDGSVALIDFGSRSLVRKLRGHNALVNAVHIFTHRSTDYLISTGNDSKICLWQYESPQADPSFVVHHTAGKSNAIAVAGDNIFVADTTPRISVYQLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X9Q4</accession>
    <name>A0A6G0X9Q4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_006992</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="VJMJ01000087">
        <property type="protein sequence ID" value="KAF0736836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X9Q4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017775"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17961">
        <property type="entry name" value="DEADc_DDX56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF21">
        <property type="entry name" value="DEAD-BOX HELICASE 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="50"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="299"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="322"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="599"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="322"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="602"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="618"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="663"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0736836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="692" mass="77423" checksum="4667702B8EBFF9F3" modified="2020-08-12" version="1">MATPVAAVNPSFLDSEVPFSACDFGLDKRLIKACAKMQFVHATLVQKHCIPLALQGKDLLVRARTGSGKTAAFCLPVLQKILTSPQKKSIKALILVPTKELVDQAKAHLWELMYYCRDVVSVLGLSGQTVNAQQALLRDLPDILITTPSRLVIHLEAGNVDLKQSVQTVVMDEADMILSFGYGDDVKKIFNALPKICQHFFMSATLSPELDALKKALLHNPAVVKLEEGNSSDGKLQQYYLPVAKKDKDLLLYALIKLGVVHGKIIFFVNSIAAAYRLKLFFEQFIINAAVLNAQLPHNSRQHIIEQFNRGLIDYLIATDESMDKDEGAEDDEDDESDEGIPEDDGETNEDLDEEVEKDEDDDGSEPEDEENEEDDEDNDEDDDDNDNEDNEEDGDEDDEDDDEEDDEGDETEKKKSTKKKSTPRNDDTFGVARGVDFRGVSFVVNVDFPKSVKSYTHRIGRTARGGASGTAISLVGKDDNDEVRHLDRVQNKQAPVMLPSQDLVRQPAPLEFDIKDIDCFRYRVEDVRRAVTGIAVREAQLADVKKEMLNSEKLRAHFEDHPRELNLLQHDKQVGKARIQPHLATIPTYLVPAALQAPTPSKKRKPHHHNHKKNAKRRTDNDPLHTFTHEENSTSSTAPKEVVEDRIHDGSYGIGVSTSGRQKWKAARKKGHFNPKTIAKKARKARLGAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XA68</accession>
    <name>A0A6G0XA68_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_006758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000085">
        <property type="protein sequence ID" value="KAF0736946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XA68"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018571"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0736946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="188" mass="20913" checksum="67B5C155C46EB9E2" modified="2020-08-12" version="1">MASPTRFASTIPPLEKRHSFAKSANEGLSMVVLVPYQLGVHRRHVKAAWHQLKNQRRLSFNRKENGFKSIAERRNESELTSMQRWRSLIKSFKASSNVARAVQDSSESAQAEHRALAAQVSALHQLIQALQASATIDVVTMQISPDRSFPTWSHAKLLSEHSMQLTTKESSAPSSKVPTSSPSVQTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XA70</accession>
    <name>A0A6G0XA70_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_006826</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000085">
        <property type="protein sequence ID" value="KAF0737015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XA70"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015985"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015986"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050836">
        <property type="entry name" value="SDS22/Internalin_LRR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652:SF8">
        <property type="entry name" value="LEUCINE RICH REPEAT CONTAINING 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0737015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="669" mass="77024" checksum="A27D5FE43618727E" modified="2020-08-12" version="1">MEAGPFQIDLSHKGYAQIPEEIDERVATLTLASNRIHSLHDIGRFSRLKQVDLSSNKIVSLLGIDALEGLVWLRLSHNSIASLDGLEHLVRLEHLEIADNALTDIDALQLNTALTYIDASANSIDVWPRFLPLIHLEVLNLNENQLRAFRNLHTVLPTNLRHLKLAHNDIEHLACLDSLQRYLTVLESLELAGNRCLLGTPHATAALTTIFPKLAMLDGASILRAPSPSLPVETDVMNREAKIQLWKQTLLERSQQEQKERQRWQNEKHNSRDKTVRYHYDKSQLGYADQPSPEIDHALDEPPLAHVSTFLPPSNNAKRSSRTNELQQELHALQEHVQQMRKYMKVQPLNFGEDLGFATKVWVKREQWLREKSAICIQKHYRGARARRRLPKKDRQAQRAPHAWMSRPVHASSCTIPRRGIPPERRVFHIYAQSIQAIARGYFTRLRLCRWKMLNNAAIQIQRHWRGYILRQRHLWMHGKRTPSAVTLKMLRSLQDVSHRVRKLERRFSIQDEAMIELWNQVQSTQRAAEASAHRQFLRSIVSLQARWRGKIARRAWPLLPNPLKSGHVMDTAVQEGMKTTLSCSQCDINAREILALREELAALKQLIVVQRPPVADVCSPRERGQLEAPCHNRPPSQMDIVTVANPLHEDKHTQSNFLSVLPFFEQPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XAH6</accession>
    <name>A0A6G0XAH6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_006844</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000085">
        <property type="protein sequence ID" value="KAF0737034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XAH6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001893"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF792">
        <property type="entry name" value="GM14286P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026003509" description="PPM-type phosphatase domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="54"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0737034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="372" mass="40360" checksum="229D5FF65D3511D7" modified="2020-08-12" version="1">MRWSIVVAVALHGARVWAACTDDQCSIDETETSILDFDFVDSSTLTEPVARVSGYSASSYSANNPNEDRFKVHIEKDTVFASVLDGHGGWHVAEYVHSNLINNTKAELVSIAAQSDSDKDAAIASKLEAAFLRTDDDLKALLLPTFELGFGQVNRVGACTMLAYLRGDTLIVANAGDVRAVLATKNESGHVVPHPLSTDNNAKHATEKARLEEAHPNEDNIVVCKSGNACYVKGGLQPTRALGDFVFKDAAFNTFRGSKQRGGGRFIPEPYTPPYVLALPEVQTHKLTSDDQFLILGSDGLWDDVSNEEAVELVQHFISLGQRDHASQALVELVIAHTAADYGVHASDIAALEPGDRRQVHDDTTVVILFFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XAQ5</accession>
    <name>A0A6G0XAQ5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_006416</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XAQ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011142"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045057">
        <property type="entry name" value="Gcn5-rel_NAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031165">
        <property type="entry name" value="GNAT_YJDJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31435">
        <property type="entry name" value="PROTEIN NATD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31435:SF9">
        <property type="entry name" value="PROTEIN NATD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14542">
        <property type="entry name" value="Acetyltransf_CG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51729">
        <property type="entry name" value="GNAT_YJDJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="6"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0737239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="109" mass="12129" checksum="D4866E90D16EFD6E" modified="2020-08-12" version="1">MSSSIVHEQDHLRFVVYSPEKQQLGYLSYEQREHGATTVLDLQHTVVDPAGRGQGLAGKLCDAAFTFAQEQGYKVIPTCSYISDTYLKRTSFPNALELVYKTPEDASAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XAQ7</accession>
    <name>A0A6G0XAQ7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_006423</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XAQ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011149"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051707">
        <property type="entry name" value="PI-Interact_SigTrans_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336">
        <property type="entry name" value="TANDEM PH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="7"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="865"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1008"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1043"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="867"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1008"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1049"/>
            <end position="1063"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0737246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1088" mass="117046" checksum="F2ADC266601F152A" modified="2020-08-12" version="1">MRKDMSANGWEGWVHKQGSVVPSWKKRYLVLADRNITYYDRDTKDPKAKAKGSFYLAGVQTNKDINNGLTLHSGDGKAMNIYTKTIGEFVMCKNAMENAVAVKNERLVEARQDYRASSIPTSSVSETYSSRSADSRSPSVDHSMRSAASSDIARYGSKPSHYGWLEKEGDLVKSWKRRYFTLHGLDITYFDNVDGVQKGSGRITDVQPLDGGLHFHLDNNRVLKVKADTHDEIQGWYDAVNRALGRPIVEMRRYTEPEDYQKLFGGDSSTLASSNQYAGAGYNASSSIANSPQTRYGAENTTNQASPYYQPTYNVPSTIANSPPPRYRNGSDPNQNSPEIAPVSSSYNAPSSLGNSPPTRYRQDTSSNQNNPSSPYIQAVEEHDDDMYQGNPYIQPSVAESDDDMFQNNPYIQPVVAESRESKQPAATPPQEKKLQSFLDKYMGDSIHESSFETGIPSMAEEAMASVTRTLVADFSNDFEMDELASPRTSELNAKGQGLWLQKGGATYFPDENAEPTVIPPRSPIAKDIPPPVIKAPVVRSTSSDEHKKKLWVPEAPAAVVETNLAVEPKKQRFGVALPGMAPATTGATAAAVPESVVKAKEVRGDNKLNDFLAKYGNVDEQTEPQASPEPQPSAATSGLWIQKGGAQYVPDESAVPTVMPTRSMIATDIPPPAAKQPIVRNTSSDDLKNKLWVASSNPVGTAKVPEETVKQPAPVNVSPPTSNKGSKLNDFMSKYGDHVEEKVPAVSPTTASGLWIQKGGATYVPDENAEPTVLPSRSPIATDIPPPVVKTPIVRSTSSDELKKKLWVAPSGIQAETPAAQASATQQTVAQQAKTIITSNEVKSENKPVVAPSISSAEKSVAAKEVTNTSNLAKNAPTNAPWSIESTKPVTSNVPGHSTTVPAANPSNAPSSDVKTQPAAATALNETTVQEVPATPPTSTAVEPTAVPRREGEKPSPATAPRREGEKPSSVAAPRREGEKPVPVAAPKTDDVKNTTQTIVEKIVESQPTSVDVAASTATSQTMNVKEPVAPKAVEYEEHLLSPVPNDGVPKSPGVKSPVVKSPAKDKHRKTKHIEGASAPKGCCTIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XBM9</accession>
    <name>A0A6G0XBM9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">Ae201684_006679</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XBM9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015560"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000315">
        <property type="entry name" value="Calcium-dependent protein kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="77"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAF0737522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="504" mass="55754" checksum="6F6E47A44A229A6F" modified="2020-08-12" version="1">MSSSVDAAASTATATPLGLFRNLFDWSNKKKSSRITNTSPIKPLSQRASIELDQSSSLVPRLQATKKSAAQSFEESYEVLKHLGNGSYSQVKQVTHRTLGGTYAAKLVEKQVLSKTDRVALSQEVLILSRMNHPNVMKLHEVLEDDMKCIMILECLDGGDLFDRVTQKGKLSEADAQSVMASLVEAVYYCHSHCILHRDIKPENILMSSSGIKLCDFGFAKQLHSVHEKASDSCGTPGYAAPEVLNGRSYGFEVDIFSLGVVLYILLCGYPPFPMKLQKLRKHNFEVLFPPKEWNHIAFSTKELIKSMLAVDPTLRPTALMLKQHPWIVEGHRRRRPPPADVLAITLRTAFTSGAGVVAMKYGRQGIPHATCIVLCPTCRMIWWRPKELDRGASFVHKLLSPRRSQGGASMLPQQPNAPPCLHPKKGICLQDVLQIVQGTKTPVFERCSHAVSVERCCSLVTDTRTLDLEFETKEMCDAMASLFTDVVTTEARSSKSADNGGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XDJ4</accession>
    <name>A0A6G0XDJ4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_005824</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000077">
        <property type="protein sequence ID" value="KAF0738264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XDJ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009271"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000003">
        <property type="entry name" value="membrane-associated progesterone receptor component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF72">
        <property type="entry name" value="NEUDESIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="8">
        <location>
            <begin position="52"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="8">
        <location>
            <begin position="155"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0738264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="250" mass="28140" checksum="90B3A6BC19151202" modified="2020-08-12" version="1">MEVNLSSEVLLGVGMAIAAVFMIQSFLWPPQAPKRVPPSSKKEEEPVKQRYFTLEELRVFNGENDKPIYIAIKGIVYDVSRKRDFYGPGEGYHLFAGREAARALAKMSFEPADLDNTDISDLSFMEKEILKDWIEKFTDYNSYPIVGRVLEKKDLTLEELSKYTTLPIYVAIRGVIYDVSIGGINHYGPKGGYKMFAGRDATRALAIMSFDEAHLANPTTDGLTEEQLKTLADWESKFQSKYGVVGKVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XF92</accession>
    <name>A0A6G0XF92_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TNFR-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_005487</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000070">
        <property type="protein sequence ID" value="KAF0738878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XF92"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004312"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026351136" description="TNFR-Cys domain-containing protein" evidence="3">
        <location>
            <begin position="24"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0738878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="325" mass="34022" checksum="E6FD679E3A7BEDF9" modified="2020-08-12" version="1">MKSILNVAHVALAFLAVAVSANSCQETFKCLREDGTVCETTSGMCPGCLAEDLDPSTGYRLCVYSTSGVCADGYNLCSSSADRPLTPTTTIAPRTTAKTTTTVPTTTKTTSLPTLQPETTVAAPTTTIADTTKAPSTTVTTTSTPTTVVPTSTPTTAVPTTTAASTNSSSDGAGSSSKPSDTSSQSSSATTPVALGVGAVAFVCLALFAFKKFRRRPHDQDEEDIATTLYSNHPTVKTNASTKPLPSSSESFSNLPTQMVLSMPSSETEMTAARNSRQGTRLSVEFEIHAMPSPVQNGNMSFGTHANLWDEVEHIKSERDAKIQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XFK1</accession>
    <name>A0A6G0XFK1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CLASP N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_005479</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000070">
        <property type="protein sequence ID" value="KAF0738870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XFK1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016576"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024395">
        <property type="entry name" value="CLASP_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12348">
        <property type="entry name" value="CLASP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="CLASP N-terminal" evidence="3">
        <location>
            <begin position="55"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0738870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="363" mass="40196" checksum="5333CD0C5BB94DDF" modified="2020-08-12" version="1">MNTLFSKIAACRDTLDGYSGAYAMTSALKKLRSSLKRAKMESKDVVVEHMLPLAASVKFKLLSSLDATVVQVTCRAVASFANTLGAAFAPFADMFLVPLLDAACVRRKSADDDAAVSMASTYCVEALAATTLLSVETLYAYFKTARATRNHRTEGGWKRHLVVKLLGITVETCTKEELEPQYSLLKEFVREALHDNFLLVRVEARQVFSSLYDTWPERVNEFVYLPAPRIRAVLMADGYATTGIGLALQRKFQSKTPAAVKRDPPKVVGPRPAVNPPNVVDFHMLLVVQLLAVLFTATVAVWQRLPSFGRRMSKVEQPTRDPPVSKGKLVPSWNRPSIQRCKRARRSHPARTHGRRASGESSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XG72</accession>
    <name>A0A6G0XG72_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_005166</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000066">
        <property type="protein sequence ID" value="KAF0739247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XG72"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010073"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0739247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="67" mass="7316" checksum="6920F1B5F8605019" modified="2020-08-12" version="1">MTIVDKIKYAWGANQSIGFKLGSWAVAAGIAYGAYVFTRESQPATEFTDAESWNKQVLAKKGKKTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XIA9</accession>
    <name>A0A6G0XIA9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_004462</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000055">
        <property type="protein sequence ID" value="KAF0740018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XIA9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019096"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="entry name" value="Sodium:dicarboxylate symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42865">
        <property type="entry name" value="PROTON/GLUTAMATE-ASPARTATE SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42865:SF7">
        <property type="entry name" value="PROTON_GLUTAMATE-ASPARTATE SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00173">
        <property type="entry name" value="EDTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="Proton glutamate symport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0769">Symport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="317"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="469"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0740018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="556" mass="59353" checksum="5756BCF2142E33B1" modified="2020-08-12" version="1">MSDKRNRGRHGILLYEAASPARPAATSDTPTWRTDFTSAPDSGFHLQLEQTNSRTSDRDYPLLADGLHNNKGGAPSRHNESSAAVPTVSSLAILIGALVGTAVGFGMYFLHLGSNWVTIIALPGTLFIRALQCLIVPIVFCVTTVVVAQMAAIGRSTILRWQTILPFALTSLLAAAQGFLLALAFKSWFPIASGRGMAMPSSAFNLALQCADGLFLTSSNGSLSCASLTNTTTALFLATNQTRTVMNTDLNFAGLVGLLVVLGNILVPVNIFTSFTNGAMLSIVMFSVPLGIATAHATSGPDEPNHILTLLRQLRDVLLRMLHGLLFLTPGAVAFLIASSIANFDKYYTADTVTQLAVLVVSVAIGMATHSLIVLPLIVFVATRCNPFPYFQHCIPAYLFAFGSASSLATLPVAIECIERAKISRSIAHVAMPFGAPLNLNGAALYYPLAMVYMANLAGLGDEWTPSRYLVLFVAGWFGCVATAPVPGGAITYLVSLWKMCFPGIPQPLSFAVLVAADFIFDRMCTVVNLHANIAVTRILAEQLDETFEVQAAHHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJH0</accession>
    <name>A0A6G0XJH0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">B-related factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">Ae201684_004197</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000052">
        <property type="protein sequence ID" value="KAF0740463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJH0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010459"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000995">
        <property type="term" value="F:RNA polymerase III general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20553">
        <property type="entry name" value="CYCLIN_TFIIIB90_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20554">
        <property type="entry name" value="CYCLIN_TFIIIB90_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000007">
        <property type="entry name" value="Transcription factor IIIB 90 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000066">
        <property type="entry name" value="Transcription factor IIIB subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.650">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011665">
        <property type="entry name" value="BRF1_TBP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF4">
        <property type="entry name" value="TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07741">
        <property type="entry name" value="BRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="Zn_Ribbon_TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="13">
        <location>
            <begin position="2"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="452"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="456"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAF0740463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="513" mass="56705" checksum="DA2BD7F767568EED" modified="2020-08-12" version="1">MGRLVCPTCQCTEIDMHEASGEAVCVSCGTVVEENAIVSSVEFTDGPGGAAGVIGQFVSGNGSSASANVGMGGKHYGSESRATTLATGRRRIKQVAGMLRLGEHYVESADRLFGLAVQRNFTHGRRWQTIVAACLYVVCRREKSPHLLIDFSDKLQISVFQLGAVFLKFCRLLQLSIPLIDPSLYIHRFASQLALGSQMHVVAITALRLVSSMKRDWMETGRRPSGICGAALLIAARSHNVQCTVADVAEVVSIGEGTLLKRLSEFSVTPMGQLTFDQMGKVEIQLLECDPPCFTKNREREAMETLLLEAGTNQIEEESWKKRIEHRWTESTKSNTLALLEDEDYGFQDANSALLQNASRQSAKLLVDSVQKRSRRWLNKQKSEASLFATLELELMESIEEDESATMNDEIDDAEIDAMILTEAEAATKTKIWESIHADYLKAQAVKEAYLETQPPKKKRPKKVKSNISAVDDASMPPPDTAQHAIYTLQTKQRSKSKNINYDVLAELFAHEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XL63</accession>
    <name>A0A6G0XL63_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">phenylalanine--tRNA ligase</fullName>
            <ecNumber evidence="5">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">Ae201684_003663</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="5"/>
    <dbReference type="EMBL" id="VJMJ01000041">
        <property type="protein sequence ID" value="KAF0741093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XL63"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001843"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000033">
        <property type="entry name" value="Phenylalanine--tRNA ligase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040724">
        <property type="entry name" value="PheRS_DBD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040725">
        <property type="entry name" value="PheRS_DBD3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003210">
        <property type="entry name" value="PRK04172.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF40">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18552">
        <property type="entry name" value="PheRS_DBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18553">
        <property type="entry name" value="PheRS_DBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="16">
        <location>
            <begin position="236"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAF0741093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="504" mass="57234" checksum="A9050569E4CF961C" modified="2020-08-12" version="1">MSYSDQAKQACEAQLLKLLDASQTIEDTYTYALNNNLDHELVVGVVKSLLVDAFVTSSDLSTSFWVLSEEAQEFVKNGSPEFQLYNAILETEGADKATLEQAIGAATFKVAQGACMKNRWIRMDKATGRIYRNADFVVDGAAEQLRLIAAVEGNVFQVADEVSKDLKRRKLISLQTRKSFQVGKGPNFALERKRLAAGLNKEMLDCEEWKTEKFKPYNFNTLGLPIGGGHLHPLMKVRAEFRRVLMDMGFDEMPTNRFVESSFWNFDSLFQPQSHPARDAHDTFFLTTPAKANSVPEEYYERVRDMHENGGHGSIGHGRGAFTRDESFKNLLRTHTTAVSARMLYQLANQPGGFQPKKYFSIDRVFRNESMDATHLAEFHQVEGVVADYDLSLGDLIGVISAFFHKIGITQMRFKPAYNPYTEPSMEIFAYHPDLKKWTEIGNSGVFRPEMLRPMGLPENVRVIAWGLSLERPTMIKYRLSNIRDLFGHKVDLEQTKSAKLYRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XLL1</accession>
    <name>A0A6G0XLL1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_003674</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000041">
        <property type="protein sequence ID" value="KAF0741105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XLL1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001853"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF214">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="346"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0741105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="618" mass="68660" checksum="5B61709917982102" modified="2020-08-12" version="1">MNASSLLESADFVARFQALSRTNVTVPSEITESSLPAIVQNRLNVSLVRWTDLTGHAQRALLWDSGFVLARNGSNYSFVQVYVRQAGMTMADIILPFNSTTTTCASTPKRHDTFEYVNLESVLRCAIDPNALLNVPLDSSSAWAQDGSNSTTVPTLRIRVHKDRYNNLTFPSIHSAATEPPAGTCTMSGDISFGLIVPCTVRRPNDGFQLPSPSPTMAAWLEGFSQSTQKNSPESAATVSPLSAPRNQTDLYWGIGAGCVGIMIVLFAVVYRKWKRLPENRRDQSGYVNRTRLKYHSSSDHFRPTNSSSPFAHDPKRRSSSFIDPSFALSVLSTINDEMCLAIESVSCDEILASTAQTEIYYGFYNHRPVAIKTVTLKQSRDKDAVNAFALEIKLMALMNHPNIVSFIGYTWNNRSISSLMAVTEYLSQGNLAQFLTENPNLDWNIKATFALDIALAIQYLHETLTPHILHRDLKSKNILMDWPHVKLSGFGLTRQTHEDVVSAGRDATRQGYYMAPEVIASGEYSTAADIYSLGCILVEIDTQEPLYTGLEMPSGHVMLKIARDGLRPMWRDNCPTDLQKLMHKCLAFDPAARPTASDVVRCLDIFVNDQGNFSRFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XM45</accession>
    <name>A0A6G0XM45_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_003149</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000036">
        <property type="protein sequence ID" value="KAF0741464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XM45"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004029"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008506">
        <property type="term" value="F:sucrose:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432:SF26">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13347">
        <property type="entry name" value="MFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="452"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0741464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="481" mass="52424" checksum="D751D810DDE19BBF" modified="2020-08-12" version="1">MASHIQDAAVPVTPNDVDYVQKDANGLDVVDKSQQEGMSIPMMFLVCCPKMAMNMAWAAQWAAFGPLLQVLLSYSSVQGVQIVGPVSGLLVAPFIGVLSDATTSKYGRRKPWLFWGCITSIMCWAVMMNATDIGNSLGDTNDDRTWTTVFVVFCYVWMDITCNLTQVPVVLLIADLAGNRQVTAASIGQGWSIAGSLVVSGYISFFGPAHQSIKSFLGMLMVIMFVCCMSVVWFVKEEPYIPAVKPNTKQQLKDAFSALYVGLRKLPKVLAIYCVIFLLLEYGYTAYNGAKGQFFGIRVKNGIASEADTCGTSGHPACTDRQKAYNDGVQLAGGVTDTIFNIFGWVYLLCMPFLVRKIGAKWVIVVACIPQVLLIIMAFCKVVIVDQIIVVLVSISQQTIFALQLPMIVFQIGLTADNNLGMYAGAFNSANCAGQFLNFALATQLVKTSMTFALPVLVGGILSVFALFIAIFFLKFDMKTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XQ63</accession>
    <name>A0A6G0XQ63_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ae201684_002532</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000027">
        <property type="protein sequence ID" value="KAF0742430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002393"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.630">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003938">
        <property type="entry name" value="K_chnl_volt-dep_EAG/ELK/ERG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050818">
        <property type="entry name" value="KCNH_animal-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10217:SF435">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN EAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10217">
        <property type="entry name" value="VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01463">
        <property type="entry name" value="EAGCHANLFMLY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="444"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1039"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1112"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1174"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1243"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="14">
        <location>
            <begin position="546"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="14">
        <location>
            <begin position="1348"/>
            <end position="1464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="834"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1513"/>
            <end position="1543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1532"/>
            <end position="1543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF0742430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1664" mass="189089" checksum="5B05BE26C41216C2" modified="2020-08-12" version="1">MAFGSFRRTDSIRSDAAKAVTDTPKDGQEEPPPSPDPDDVDDDADDNADNMTDNEDDALTHITSQLMMTEVEESEEQAVSAYMTRQAQRAEVTGLSPMEEMRLAHGELAAKVAKKRHIEELPPSRIQQIHFPNVPIKKVLKRMHTSIAGRSFRNAPTVVCEAEVKRITQELASNMDNMTAEQAINFVQSVEQRENIIKMRVDGYDTKHIPWYLVSPTSKFRVRWDILCVFLVMYNCYYIPLLLAFGASSNAAATFAKLDNLQFLTDVVYILDVFFNFFSAFESRGRIETRWTQIVKEYTKTWFLVDAVSAMPYEAFSMMHEDSRSGFDDDAAESTKYLRILKLCRLVGLPHILNRVEYALLIKSTQSGILKFFLLVCLTSHWSSCFFFFLSNGVPGGWVSKQGLEHKTLFDQYVNSFYWSIMTMTTVGYGDVTGQNTSERGFSIVAMVVGAWIFAYGITNVVAAVANLNPNDTVFQRKMDGINAFMERRDLPMELRTEIREFFFNARLSTENKLKNESKILSELSALLRSKIALAINDSVLNKMPFFEGADHNFLMELALSMKMVCFPPHEEVVIEGEIGQEMFFIFRGAVEVVKDNIQLAVLGEQQYFGEMAIMNTNSMRLATVRTLCFCELRMLTRQKFLLALAHYPNMRQRIAKIIHRRKAMNNQEMARRRSNDLSPVVKRNRKESTTPMENLVASIVQSHHRASDPLRGHKESDIFAVDDNEKIVGSTMDRISQMDVQSKPAASQDSMLRIIQALLEQQEVLAAEMSKLEARIHSTECNCCRFMHNIEQLYYFQDAMRRPRVLTKASPRGSDGRTYGGQEEALYRAVPLPATSEEDHHEGSSILKPFKDEDDESSAEERKIMQGMMDANSRPTKPHMLSAYMARQTKGAHVVGLSPIEEMKLAQGEFQAKAATKLVNKATRLSGLQSLASSLHAAGLRKQASPPRKKSMAEKLIATLNAGGQRGSASVVEPLPEEDLRKITTTMNKNVEAMTPEQALNFVEDAAKTETMIRQKDEELRARKLPWYLIHPMGKFRLRWDVASLALLIYTAVFLPLEMAFSMHLDMDTLGYLDVFLDSYFIVDLVVCCLSTYEVRGAVERRLSHILRTYFYSWFCIDLLASFPFSIVAVHDLSINPKYRLIKLVRLSRLPRILNRLEYTLLVRSTIGSLLKFFILVMMTSHFLSCGFFYMSYGDPDGWVAKVGFNDRPLSDRYVTCFYWSIMTMTTVGYGDVTAQTTAERFWSIFAMVNGAWIFAYGITNVVTMVSNLDVSGKQFQLKMDYVNKYMEVRDLPLPLRAEIREFFFNTRLTVDNKLKNESKILGELSALLRSKIALAINDSVLNKMPFFEGADHNFLLELALSMKMVCLPPHEEVIMEGEVGEEMFFIFRGAVEVIQGGVQVAVLGEKQYFGEMAILNQDCLRRATVMTLCFCELRMLTREKFLLALTHYPNMRHRIAKIVHRRNQSKSTRDLLAENNRKRSTILEKMAATILLQAPPPLRQQASAPPILEKTCEEASPPPSRTSTDPSLKPMSSSPTDQFSYPETTMNRISQLSFNGVLEAAAMPRGSAEQQIISLADSQEVLAHHIVKLDEKWDMLQDRLLQMEHELAYYRSKYGPAFLSQPGSKSSHCVMAADETQRRSELEIGDDGSQLNHLTHEQRGVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XRE1</accession>
    <name>A0A6G0XRE1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_002295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000023">
        <property type="protein sequence ID" value="KAF0742901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XRE1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006899"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40855:SF1">
        <property type="entry name" value="CLAVAMINATE SYNTHASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40855">
        <property type="entry name" value="DIOX_N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026276119" evidence="2">
        <location>
            <begin position="19"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0742901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="465" mass="50897" checksum="B553AADC9A19292B" modified="2020-08-12" version="1">MIGLIVAACLAMFHSAHGMAEYVIPSFDLNERGSHLSLIKALEANGVIALKNVPKFASTRDPYVQSAFACMKQHPNLDALMQKKLQDGTQRTTISMNADGATFSTALTTQCPKFIEAQKSYNQLLRDVSARLANVLSKDTEISSPLVDVVNLGAHLDHIHSYTPAPSSIFTPISSLFKAQTQLSLDFHTDNGVMLLTSAPYYFDDQGSVIKDISSGLVLRLSLHGKAQQVMPHLSSDELVVMVGEGFSRWGNFGYKFPPVLHAVQMPQDARIASRLFSGRMILLQNDATLAQSHLSFKDYADATTRYVLNEQTGDDSTTLSTLGCPVGRTLLASDLSCTLGIWAPSNASDPSTTNEQCMFHCNAPNMKKDVEMCKSLKCELVDQVMEGGTMCWMLCVQHLDTCNIADQVCVDQSLACPPPSKTWEFWTVVAYIAAIALGLWAAWLLWKRCTNPATPSETVPLLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XRS0</accession>
    <name>A0A6G0XRS0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Transaldolase</fullName>
            <ecNumber evidence="3 8">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_002212</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transaldolase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="3 8"/>
    <dbReference type="EMBL" id="VJMJ01000022">
        <property type="protein sequence ID" value="KAF0743158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XRS0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015856"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00957">
        <property type="entry name" value="Transaldolase_TalAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000088">
        <property type="entry name" value="Transaldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00492">
        <property type="entry name" value="Transaldolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004730">
        <property type="entry name" value="Transaldolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009001">
        <property type="entry name" value="PRK12346.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00874">
        <property type="entry name" value="talAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683:SF18">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00958">
        <property type="entry name" value="TRANSALDOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0704">Schiff base</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0743158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="320" mass="35371" checksum="B3379ABD2F990E77" modified="2020-08-12" version="1">MSHLDQLKELTTVVADTGDFGSIAKYQPQDATTNPSLLFKAAQMPQYADLVTEAIAYGKGLTGVTEEERLGHIIDQLSVNFGRKILEIVPGYVSTEVDARLSFDTESTIERAHRIIDMYKAAGIGKERILIKIASTWEGIQACKKLQEEGIQCNMTLLFGFPQAVACAEAHATLISPFVGRIMDWYKAKTGKTYTAVEDPGVQSVTRIYNHYKKHGYKTIVMGASFRNTGEVLELAGCDRLTISPNLLEELANATGAVAKKLDAEHAALNYDHPKVTFTEKEYRFAMNQDAMATEKLSEGIRGFVADIIKLEEILKAKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XRT0</accession>
    <name>A0A6G0XRT0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_002204</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000022">
        <property type="protein sequence ID" value="KAF0743149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XRT0"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0743149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="169" mass="19069" checksum="E64C409EC013CA47" modified="2020-08-12" version="1">MARHGYHYNGLLGAPLVTFSAPLVLARSAAQRENSPLRIFSGLVSFDLKLRGISPTRGTSYNPPSLEVSRHYKTYKRILLFVLFNDAPSFDKVVSSVGHRHVVESSSSWKSGASRLGTCPLSRLVDIKPVENAHAFLDALVDRTTRFRRLIRVVFPLRRDHTVHVVWFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XRT2</accession>
    <name>A0A6G0XRT2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BLOC-2 complex member HPS3 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_001964</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000019">
        <property type="protein sequence ID" value="KAF0743275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XRT2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019771"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017216">
        <property type="entry name" value="HPS3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28633:SF1">
        <property type="entry name" value="BLOC-2 COMPLEX MEMBER HPS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28633">
        <property type="entry name" value="HERMANSKY-PUDLAK SYNDROME 3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0743275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1124" mass="123868" checksum="4CDE3BCF12444DA5" modified="2020-08-12" version="1">MAPGVRTITHGETSCICGISLTERDATFAVSDESRVRIYSASELVLLHEFSSIHGRILDMHHTTFCDAIVTLETHGADDDDGDCYLCVYHDWRSSNTPSPSQNLVRAYTLPLAIARPESVCLSVCSFTGRVALATADGFGVNIWQTSDGFFEHVMELKVDRDFQYVSVHGAYVAIASRTEVRVMEIIVEPASSTSGRKSNGGDVKPKLLERKKELIYNTLEKDRIPKIRIPSVSGISTAVAHEAVVQVMGKDDAQLEAYNLAGLVHDQDIRVNAALEYVHSRVQVLLQRFVPPNHVISALRFLPETVDPSRVAQSRTYARLLVSTATESFLYYFIADEVDATRDLMAKKILRREADPIRGVIEPIAITNGTSNAGFTESTSALETRSGRVAMMYKFSAPVNCVTANSSFLFAATLAGLEVWSLWSPCHHIAAKKALDSTFALQPTQPQLLGVHPLPNEPVAKNIVALDSYVAVLLQASLTEESHPLKNSSAVARRKAHALPFEMRRHQAQVKMADGIVVVFPQSPPSTMFEKAKVETSGNHVVTKDQMDLLLSLFSLYRFRADVGLHALHDMSGLTKETLALQFEISLYDSLARACAAHIAHLYTTPAFRNLTRAALLYVASNVPSRDVLVKFRSVEKANDPTDVIDATAVYLEAFLFPQKDPANYLGLHLPVERDDDNDVSFTGVVLRHYGDHAPEQLSRLAIDSSLTWTLLDIDYCLAKLRFAEHKSVLIRIGILVLLIRATGLPDLESFVQAKHAVLPADDEYSDASISNRIEWLAENYPEPLIHLCVTHPEFLIQKHRRADDEDTVAVPPMFYRSILATGLLAKAPTKLLSALELIFYSALGHQNAFLTAMSFCLGVLGGGDAASRIRSGHSNISAAQPLETSEVYVLGAMHFMLLHMSKYPGGDTTIQASLALEYIHVCIRLSLVSSPNAKAMLTHALASRSSLLPKKQTPVPSFVEPYLDATAGLAKNSHIDQTLHQLYLFACQLVPTVDAATLATLCAFYKDAGPIPTLMELLILPRVDRLEDGLRKIYGNPLYYGYLVGYATAFCHSLEEWKTFLHIVLDSTSPLSSELLSTVQDTLDHLALTFTPQEFLAIIPDQADASVFLDALARCVRKHEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XTK6</accession>
    <name>A0A6G0XTK6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_001585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000012">
        <property type="protein sequence ID" value="KAF0743944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XTK6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012261"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0743944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="149" mass="17887" checksum="B334E22EFD965F69" modified="2020-08-12" version="1">MRQRGMTHVSYILREGFATMMLPQLYTPTTAQSLKTLASLMDLFPFLERHLELVLKPDEFMYILFAKRWLQVRNETNVTLKTKPRMAERVRQKISRRFLAWSLEKVPRVRRQKSSLATMSFPRVNFVRERRRRLTQSMARRLGRQQSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XUF8</accession>
    <name>A0A6G0XUF8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Leucine-rich repeat-containing N-terminal plant-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_001293</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000010">
        <property type="protein sequence ID" value="KAF0744152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XUF8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021440"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026045132" description="Leucine-rich repeat-containing N-terminal plant-type domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0744152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="37748" checksum="77CA55469AAD44EB" modified="2020-08-12" version="1">MQQFALVLVWIAAVAESSLILTQCWTQNDANSSSVPCLNNTANGTVVYLPLADNQTLSSYSYANLNISDVQDLPPNAKWIDLSQNNISQISCRIPSSLKFLNLSYNTLRDSWIQTPNSVTTLDVSYNQGGLPWIENIKWATYFPNLYRLVFRGNNLTSIRLGFDTYPPDRPFALDLSANPISQAMVEANVYNRLSAGALTLDPNSYIETLRACGGDARYVQQVMTWPTTYLPQGEENFDYSTRARYFYVCVPGIASYAFDIFTNPTQRAIEIGLLVVGCCFSIVMVALVVFHIRTRWRERHELYLRGTTCSSHCSVDDMPSDPAYHEERPVVRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XVB0</accession>
    <name>A0A6G0XVB0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_000970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XVB0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010437"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052050">
        <property type="entry name" value="SecEffector_AnkRepeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586:SF3">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0744494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="295" mass="33171" checksum="09DAF741F8320F90" modified="2020-08-12" version="1">MTSSRHTKATAAISVMTSTDLLLFILDFQQGVYYAYHPLRRLGCLTVTPEAPNTMDQVDELLAPWHAYHSHQRTMALIRSTDQYKHNLIAAHAAFTGNFPVVTTMLEKTTHKCIEANLIDWAASAGRLDMVEYIYQATNGSMTTTTSAMDMAATNGHLNVLQWLHTHRQGRCTVAAVRGAAANGHLDILAWFASVGIHSISSWWIEAMTAARSNGHTTIVQWLHQHRVDTMQGNNKCLETRQPDSIRHENISSGAGRHADVTTFRSVRPRRLTYPIEKQSPWREHSQQQTSRRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XVC7</accession>
    <name>A0A6G0XVC7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_000962</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XVC7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010430"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0744486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="463" mass="52624" checksum="1EC784A8A8CC742F" modified="2020-08-12" version="1">MNTTPTVASVVHSSIFNSAWIKIQKTLMDHMNDFVSSYSENPTASQVLFKLCGPAFTSTYYPTANLNAYILEEPYMTAETRRDLEAQLFVAIVQFLDSKLVDLLHSDPEVLRLLAHMRQDFKRSCNSSTPDNAAMQLIHLLHGAFFRCPTVELPPNPPATSPAFAPTILWNQTYLEYYTDRFLNDQANTDEDTLFQSLRGRSVPLPLRQLLWFRRLHRPDALADHSWRLKANQTLLGTNQPWLSPVSTLIFRLVRESLADRFPHAADVGPRLCDLLNVWFVLTKLQSAHFVSLAIPLVRLFPNFDSKSIELASCLLVFLQTYHVAGMSRSEVAAASQRVWRSVGERFPSVFRHIEEVLAQSRLDMPLKPADLFSSWLQVALVGYIRPAAADFIWDQCMLSPVGWKAELDNFCVDIVGLLIPRLMSASSVEELQTIVDSEPRKLLTRDVRRAMSERCQIKQTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XWD1</accession>
    <name>A0A6G0XWD1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_000720</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000008">
        <property type="protein sequence ID" value="KAF0744813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XWD1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010847"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052431">
        <property type="entry name" value="SKI2_subfamily_helicases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44533">
        <property type="entry name" value="DEAD/H RNA HELICASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44533:SF4">
        <property type="entry name" value="DEAD_H RNA HELICASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="211"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="34"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="443"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="609"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="458"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="614"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0744813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1032" mass="116262" checksum="05AA9785EC198559" modified="2020-08-12" version="1">MSSDGMHDVNWHKIFPKRIPVILRDLAPANAFNPTNLWPEEPAQAAGDGPKKGDGTADKGKKDKKEKKAPVLKKADLIRLQLAKDLEDKKAKQDEEKLSNAKYVNLMDMKMATAAGRMKQLYEIKKEFLAKKNYIDAVDTLWEIQHMNKALSEDEVAVHKKYKKYAKKAMDFLKDKPLIPFQLTEMSDRLPPLNLHHMNKFILDSWQKEVLTHIDQNHSVVVCAPTSSGKTVLSSYVSVIGGKVLFLAPTEPLVWQVAALFQAMVKGTVALVTKGTVFLPEGFRICVGTPAAVESALLDIGYDFQYCVFDEVHDLNGEEGDALERICKAMSCPFLALSATIGNATKVVEWWRGFHPNPIHLLEYRGRFINLQRMVFQKTQVVPLHPCAAVTIDYLVDQGFAAGDLAFTPRDTFALWTEMQKVYPKEAIEDLAPEKYFESTISNGTAASDAAPKKSKKSDKSDKSSKDKKSKKGKDDDKDDDDNLDFLQPMCHRITLLESKQYEEVVKDRLQQLAVNYPTETQTILNNLGLSKLESTDLDITALIFDLVGKSLIPAICFQLDSVRCRQIFDELLVGIEAAQDAKYPGYRSKLEEEHAEWEKQQAIAKKAQAKSKSLQEDQEREAQEFQESNAPDIYAPHPEFVLTPPGFRLSASEFREIKWQLRRELSESSDDGHPLVRSLRRGIAIYNENLPAAYLRIVQSLAQAGRLAVVFSDEALAYGVNMPFRTCCFCEDAPNLSSLMVQQMAGRAGRRGLDRQGNIVFSGIAWPRMQQLMRGLLPNVEGNRHNLYPTLCLQPFLSPVVTDEIVDRMAKHSLPHFMRGEEMSDYLIKSRAFMTAVGVLSPSGTLNVDTSIARLVWECRKDVAESIGIFHLLELMLSEFGRVPGDNIGHQLALFNMLLRVVGREPYHAEYAHATPLTVVAGQEAVWDKVTAILQDLHDKVSKLDCPDLVLPVPLNEPLDGYVWSTLVENVIPSGLKTAQLNAIKKRLWHVGDKLRLMHNLLMYSGRYGVLEEIVRKCFRRIKWILIDSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XWQ5</accession>
    <name>A0A6G0XWQ5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_000742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000008">
        <property type="protein sequence ID" value="KAF0744836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XWQ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011722"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0744836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="143" mass="14942" checksum="F122552BC7BB2662" modified="2020-08-12" version="1">MFLLAQGRADGVSTTVAKPPVDKTTTTSSYPHELKDEGHSAKQDYPGQEDNYYAPSYGRDVYGPPRQESSGYGSYGQYGPSGNENGRFGGGYGNYGSGYGNYGGGYGNYGGNGFNSYGRGVGGGYANYVGGRGIGRYGGGYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XXA9</accession>
    <name>A0A6G0XXA9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_000391</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XXA9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016910"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026337305" evidence="2">
        <location>
            <begin position="22"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0745370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="340" mass="36843" checksum="977BDD46DDAFD860" modified="2020-08-12" version="1">MKSTTFMLVLLGLVCVSFVRADCKACVSFGECTAAYRGAPGQSCGVVAGKTCCCPAAAYCASSSDQCLCKASHGPVLASGSDKPKAVTWMIFVLLIVLGLYLLFRCCCGETQQRQLAGDVRMVKIMRATPTTQTVYGSIPRPADPRVSENAKAVRANQPAQYALKVQPDASYYQPTVYDQRVSENAKAARANQPAQYARQVQPDASYQPWVYVPPTTHHTTSRTYQSSYNSGNTYSRGTGDYSFAGDSGGYTFSGDNDRSSCKLEITRFVLSPSREKAPHCCRCCSHLFRIMAAAIEKSCANCNASHAADILRPPCSSLSTYAHSLITMRMHPRSLDTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XXE5</accession>
    <name>A0A6G0XXE5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_000429</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XXE5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001265"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0745410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="173" mass="19543" checksum="9A3590E3ABA642C4" modified="2020-08-12" version="1">MDESGDGGESKRSLFHLRRKPPAKSKLFFELSHAQQRKEGKSASVLRQLEGNSLSDKLATYRKTIRFLIKAGHDDAVQMVTDIHKGLQDPNGRDEKGRNGLHFACRRGAEGAVLALIKEDGSIDEPDLEMRWTPMHYAVMGKQKLMVSILLKYAPTPYVTVNRRDVSLCLYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XY35</accession>
    <name>A0A6G0XY35_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_000119</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000001">
        <property type="protein sequence ID" value="KAF0745668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XY35"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009010"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="7">
        <location>
            <begin position="140"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0745668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="447" mass="50727" checksum="7D8B1F1D5D8B7FCF" modified="2020-08-12" version="1">MAGEVYSSEQFLDEPVRSRRPGSSAASAAQVSDTRVEKEESYEHTIRHSWPLIFGIAYLLALFYGFLTMVKTYEIDPTYGNWTLLQYQEDNLLGERCPAVDHGVAWKELKRKLLRCRRGQYYDPAHNTCFDCPADTPDTKVFNVFWETQSNCQHLVGNENLRFITHVMWSFIELADDGSVPPRFQYWSQEHIKDCILQLRMRCIKNLVALGGASNRDKFLGLKDPANLQRFKDSAMKVVEEFGFDGIDVDDETGNMIGTKQDWLKNQAPTVVTYLQALRTGLDTIRKPDEPRLVLSWDEFPSSWDPPEPNNTNYPGCIIYQDGEDGWHRCYEPKISDIVDMVNVMIYNVNGGDWVYQTIMQKTLPEWASAAVPKNKLVLGACSGMGCVMSQPAGQEVFNAGNGSAFYRGTMLWSGTIDILYENSSCLSRMGRAGNYGVKLPFRPTIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XY51</accession>
    <name>A0A6G0XY51_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_000481</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XY51"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018131"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0745467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="432" mass="49529" checksum="0F8B251C5C5E0056" modified="2020-08-12" version="1">MMIGSYIAKPKHLFTYLEALRPANLLGPLEHLWQLGLVKKHSDVWPSLVLWNDDVAFDSNVMTSLQAFAKYYKVVEVHDIENLQSLNPQSFDPSTEWHMYSHTTRMIDTWQEWTSLRVTRWQWNLCRNALDLARSSFLAALPQLSYLSSLSLMVQDSTLLEAVLAFASNSRELIELRLDCFLTQRLSVTTEMLQNVIRWFERKPVRMFKFSSWNTRPTDPAVRQIFYRVVFGCPTLDELVCLWTDLNDMDFTDIQLHMRSLVLHRCNLGSDNLSALADRLPGSSMTHLAVKALENDNFSGLERLLQVLPSSSIKDLDLSGSYIEQAAWFSLAPLLSSCRLESLVLVNTSLFSDQIELIARAIQDNGTISRLDCSRNPLDVQGARCLIESATHSTRPIHMRLLYLIDSFNISHAGRDELKQLADQRGLNHFYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W305</accession>
    <name>A0A6G0W305_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_019171</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000443">
        <property type="protein sequence ID" value="KAF0721349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W305"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019642"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31973:SF195">
        <property type="entry name" value="MUDR FAMILY TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31973">
        <property type="entry name" value="POLYPROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0721349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="34727" checksum="0FF35BF6B1E66CD1" modified="2020-08-12" version="1">MTRRVGEAYLAMAVSLRLVHPSDEELPYITQETINRNANNDFGKLIAVKKALDILALHQRFNVKQEYQTKTWGKWACTEPNCCFVVKATKRVSGSVQITSMDLTHNHPLHQEKPRRRHPGISHDLVVETVATNSLQASIAPRNLAGKEIQHTVLSVLGHEISASAANKAKQHLVKFLYGAIDGAFEKLKSYFAIVAEKNQGSIAKVQKTHGVFRRSLLVPHFCIAAMKFCQPVVALDGTHLKDLMNSNGVLLVATTKDPNNHLLVLGIAIVLVENYDNWQWFMRHLQVAGILDGDVVILPDRDKGCLAFAMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W4Y7</accession>
    <name>A0A6G0W4Y7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TNFR-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_018907</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000364">
        <property type="protein sequence ID" value="KAF0721800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W4Y7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016273"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026248640" description="TNFR-Cys domain-containing protein" evidence="3">
        <location>
            <begin position="17"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0721800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="28275" checksum="95F62BFF3BE344F2" modified="2020-08-12" version="1">MLKMAVFLSLLSATYSQGSDDSDVCSEQTCILGNGENCDRALEDCPPCMRYKNRRPRCEETFFGMCTRWDEEYCFDWTPTRRPSPSPSPTSMPTMTPTTTTSIQTTSKPTTAPTSTKAINNTASPSLKPSTTISQLLTPAPSLTLGEEPAKSKTTTWLMYGGIGAGVVLVIAFVVLFIRHRRQQDSESSDEGSPRHPYVEHAPVKPVSIVPEHSSTPNQSLNRILDNTTQNELMDADEITTQRPRRLSDTTSSVEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W593</accession>
    <name>A0A6G0W593_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_018508</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000338">
        <property type="protein sequence ID" value="KAF0722343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W593"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013725"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
        <property type="entry name" value="FYVE_like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="START" evidence="6">
        <location>
            <begin position="78"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="5">
        <location>
            <begin position="266"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0722343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="410" mass="46515" checksum="F0FCBDB755585B48" modified="2020-08-12" version="1">MPAKVPLSADFFQCPPLSREAIQRFGDLGRQSAETLICKAKLRDGACDWKLHREESELKIYKEDSCTEIEGPPRYCGVMQVVGELDEYIDLFRYDTTDQARESFSVGGPFVDVMVLYTVHHRNPYRPNDSTRIKWFLAKSPMEGFVPRRDFVVLETDMEFKVDGKRAWVRSHRSVQLSAVPDLRRELNCVRGEMNDMGHVVVESDRSGYLDVTYVADMEVNGMAQFLAIDSALKSWLRSMTCIDRCMRENRLSRTPFLDPTQICALQTASTCSLCRQRIGSMRKKANCFKCGDVFCRTCCPSWKVRMDGQEVPMRACLPCSLNTSALSSWTQNSSISTVEPPAMPAIQTQTSNEWALLETNEDDSTIDDDDIFVIDVSASIDSNLVNPIILDPPSMRDDFDLLSTYKMSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W5C0</accession>
    <name>A0A6G0W5C0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_018619</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000344">
        <property type="protein sequence ID" value="KAF0722192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W5C0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002895"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47169:SF2">
        <property type="entry name" value="OS01G0541250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0722192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="241" mass="27767" checksum="25DCF44825B8B28D" modified="2020-08-12" version="1">MFLSAVARPRFIDDTGAWWDVKIGTWPFVEIFEAKCDSVNRLAGTPETKPITVAREVYRSFLLDKVLPAIVEKWAKQHAKIILQHDNVKPHMRSSDPALRESFRQYLVLGWCFDLRPQPPNSTDFNVLDLGFFAAIQSLQHRQSARSIDELVVNVINAFETYPFEKLNNAFITLLWCMIEAIKCNGDNTYKIPHMSKEKLSRLGMLPKKVPCDEELFRVVLTCLDAHDQEEMTKILQAEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W6T3</accession>
    <name>A0A6G0W6T3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_018158</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000323">
        <property type="protein sequence ID" value="KAF0722806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W6T3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013032"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0722806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="161" mass="17225" checksum="64D292EDCBD4A223" modified="2020-08-12" version="1">MHPLLGPTCRRIEINPSSTAAQKESPPQKMTTGPTRPDNGYAVVQVEKAEVHASDCANVIHIWALGVIAVIGGQFYGWNASYAAGFVPFFCVQIVVGVAYVVYVACISEVGGKVPGGSYGLARAVLGFYPGFMLGCLEILEYTSFAAVSVLYVTNFTVDYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W7T4</accession>
    <name>A0A6G0W7T4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_018304</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000330">
        <property type="protein sequence ID" value="KAF0722571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W7T4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002280"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15827">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 2-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15827:SF2">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 2-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0722571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="186" mass="21643" checksum="26B97A1C771AB948" modified="2020-08-12" version="1">METPLKKFEELLKEWENCVSKGTARLTQIANSNQKMTHADGESWGVLTDANSLHQTLRRKLEREAHQSWKQLDSLVGQLAKTVEKMRVFCLFEVDSEIALDYNGCPTLSKKQYDVVFQRVVTMYQQELMAKSLILHDILDCHDHDTAVLYIASWQMQPYIDKTEQQELLQLLTPPFKRESTQKLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W9G4</accession>
    <name>A0A6G0W9G4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_017342</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000294">
        <property type="protein sequence ID" value="KAF0723848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W9G4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014181"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0723848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="588" mass="68086" checksum="A10CF43CA45A5F98" modified="2020-08-12" version="1">MYQGFASISGKFNKFVDLDSPATQKEKLILNSRSEIYREKELWTYGFLRALLDYCCRAKLENGRMIRMNEVTLNSMKLQNKNVPFFILDEMSPLSSGTNLAAFQRNVFRVCGLVVVIMGTDSKVTNLIPQTSHSWTDEYLWMAILPRFPRYQLVVNEPDEEVWMSIVKRFPIVEYIVRNPRGRFARLFTEKVLKVVKRHQATIGKKEAEIRLNELLDDAFNAIHSRVLDKKLKFDALYEQMVAVSYTNVRKYDQQPPKKKARLEVGTSGLHGHFADLIDESPTDIYLSRDGFHKESPDDTSPSWIENTSPWEVKCSLPAIDEDVLLGGKSRSAYFENDVHYSTRWIFEETRKHDDHGNTEAPSNDYRPFENMVAHAIFCSSRRYGVQGIPFNDFMPCFVGEFQAKKWEKMPLKLVVEEENTTREILASDLLQGYSSLVEKLSVGNVIPFLAPPNAEWPESILQANEQGCNFGHLVRPDNKKRCDVYVQNKGRVPLFFCKCKYRDDNVDISIIHGIIKRISENDNWPWEMIFVFCRRFATFPSDWAAEYLSIGCVKINCKDANVTWIHNPEDQNREQLVIVMEIPECNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WAB3</accession>
    <name>A0A6G0WAB3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_016964</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000273">
        <property type="protein sequence ID" value="KAF0724300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WAB3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021502"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001518">
        <property type="term" value="C:voltage-gated sodium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005248">
        <property type="term" value="F:voltage-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000009">
        <property type="entry name" value="Voltage-dependent T-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043203">
        <property type="entry name" value="VGCC_Ca_Na"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10037:SF62">
        <property type="entry name" value="SODIUM CHANNEL PROTEIN 60E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10037">
        <property type="entry name" value="VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="12">
        <location>
            <begin position="48"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0724300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="324" mass="36633" checksum="99FFFFA693A059DE" modified="2020-08-12" version="1">MGDAKAHHQESFQSRYISGHFRKFQRIILGCLIAKLPVRKVCIQIVTWKWFDRFIVACVIFNTIILALTDYTNAWAEGPNATIWINSFNDMCNSVSFYIFLIEALVKIVAMGFCFGQGAYLSDGWNRFDFLIVISGLLSIMNIKGIKVSFIRVLRVMRPLRTLHSVPGLKILTNSLLASLPALANVFVLLMFCMLIFGILGMEIYRGAYHFRCRITPFPVSYIDLVQATPEQYMCLLPDGTQIDQNIDVWDTPQDCFWPIDASETIPLVCNEQAGVGRQCEAPGTVCGSNFDEALPEQADVNQNHSPWRHCNSVGIWTNPPYIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WB42</accession>
    <name>A0A6G0WB42_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_017646</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000306">
        <property type="protein sequence ID" value="KAF0723449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WB42"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006631"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058353">
        <property type="entry name" value="DUF8040"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF221">
        <property type="entry name" value="NUCLEASE HARBI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26138">
        <property type="entry name" value="DUF8040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8040" evidence="9">
        <location>
            <begin position="45"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="176"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF26138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0723449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="406" mass="46608" checksum="219892C46A46A11E" modified="2020-08-12" version="1">MPSLYQVIAYIFFRRKVCRRRQLVLMNSLIYHYIAYVHKTLKHVSILSGPMFVQEILNGNPTVMLDNFRMPRRIFDALANDLERFGALKSSKHVSVQEQLGIFLYFVGHHASNAALQSRFQRSGETITRHVRRVLAALVSLAPRYIKIPDDNSPVPSQIASNPKYYPFFQFCRMAIDGTHIPVWVPEKAVAKFRGRKGVTMNVLAACDFDMCFTYVLAGWEGTAGDGKVYADALTKGLTLSRNMYDLADCGFGLTLKALTPYCGTRYHLKEFAKGAQRPQSKEELFNLRHAKLRNVVERIFGVLKKRFPVLNSPVEYDYGFQVDLVLALCAIHNFIRMNGLLHDVFTQEAIGELSERNQQPMESTDHQVVTDEPENEEAKSWCDAIATEMWSQYMETLRQRRFNRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WBQ1</accession>
    <name>A0A6G0WBQ1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RxLR effector protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_016585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000261">
        <property type="protein sequence ID" value="KAF0724836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WBQ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017880"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026029127" description="RxLR effector protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0724836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="170" mass="18155" checksum="113DF05DF1C76491" modified="2020-08-12" version="1">MRVLTPLVLVASAVLAFKQPRHDSSLMANHQQVRMDSAIQDHRILLSDASVASFNSPKRSLVANGNFITSCFGSLCGKPGKKAARESSRESSRHSEVAPHVGNTATSPVRNAKSKGSKNQQLGGSGSQSFGGSGRQPRGDTRRRPRSGSNGRVPLKDITNTVGRSNSRHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WBW9</accession>
    <name>A0A6G0WBW9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">formate--tetrahydrofolate ligase</fullName>
            <ecNumber evidence="3">6.3.4.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_016627</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6S)-5,6,7,8-tetrahydrofolate + formate + ATP = (6R)-10-formyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20221"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.3" evidence="3"/>
    <dbReference type="EMBL" id="VJMJ01000264">
        <property type="protein sequence ID" value="KAF0724753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WBW9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003826"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004329">
        <property type="term" value="F:formate-tetrahydrofolate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009257">
        <property type="term" value="P:10-formyltetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046655">
        <property type="term" value="P:folic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006555">
        <property type="term" value="P:methionine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00477">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000245">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001123">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.770:FF:000001">
        <property type="entry name" value="Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.410.10:FF:000001">
        <property type="entry name" value="Putative formate--tetrahydrofolate ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.410.10">
        <property type="entry name" value="Formyltetrahydrofolate synthetase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01543">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000559">
        <property type="entry name" value="Formate_THF_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020628">
        <property type="entry name" value="Formate_THF_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01268">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00721">
        <property type="entry name" value="FTHFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00722">
        <property type="entry name" value="FTHFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0724753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="635" mass="67606" checksum="25B65CB855DEB246" modified="2020-08-12" version="1">MTALPPSALLFPVPSDIEVSDSITPAHIGDIAKASGLLEDELVYFGKTKAKVQLSVRDRLQDVKDGSYVVVTGITPTPLGEGKSTTTIGLAQALGAHLKTKSFACIRQPSQGPTFGIKGGAAGGGYAQVVPMDEFNLHMTGDIHAITAANNLVAAAIDARMFHESTQKDKALFNRLCPVKKDGSRVFASVMLRRLAKLGIDKTNPNDLTEDEIRRFARLDIDPATITWNRVLDTCDRFLRGVTIGQAATEAGHSRDTGFDITVASEIMAVLALATSLEDMRERLGRMVIGMSRAGNPVTTDDLGVGGALTALMKDAIMPTLMQTVEQTPVLVHAGPFANIAHGNSSIIADQIALKLVGPEGIVVTEAGFGADIGMEKFFDIKCRASGLVPQCVVLVATVRALKMHGGGPTVTAGKPLDPVYVDENIDLVTVGCENMMQHIRNAVKFGVKVVVSVNRFATDTDREIEIVRAKALEAGASAAIECNHWAKGGAGAVELGQAVIDACASVPSNAFKFLYPLEWSIEQKVEAVCKSIYGADSVEFTPLAQEKIRVFTANGYDKFPICMAKTHLSLSTDPSKKNVPTGFSVTIRDIRASVGAGFLYLLCGDIMTVPGLPTRPGFYDVDVDCKTGKIVGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WD75</accession>
    <name>A0A6G0WD75_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar fusion protein MON1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_016236</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000246">
        <property type="protein sequence ID" value="KAF0725271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WD75"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005918"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043972">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043971">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043970">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004353">
        <property type="entry name" value="Mon1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027">
        <property type="entry name" value="SAND PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027:SF7">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN MON1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19036">
        <property type="entry name" value="Fuz_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19037">
        <property type="entry name" value="Fuz_longin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19038">
        <property type="entry name" value="Fuz_longin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01546">
        <property type="entry name" value="YEAST73DUF"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FUZ/MON1/HPS1 first Longin" evidence="1">
        <location>
            <begin position="7"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 second Longin" evidence="2">
        <location>
            <begin position="161"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 third Longin" evidence="3">
        <location>
            <begin position="286"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0725271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="45648" checksum="5DC4C3BEC627383B" modified="2020-08-12" version="1">MELPEIHVLSAAGKPILSTKTGDECSNVSIAGLIQGISSFADDSLRQIKTSTHILSFLPSPPLLFFCATSSTFYGLNVSRLLLLLKHHLLVFLTQNGLSLIESNPNYDLRNLLYGTHDVLTAIAAAWTQQIWTQLDDIGVRFWPLAIEARRSIQNAIDVSGLVFGLVSCQGHIVSYKQGHKDHPFRVADVHLLLHVVDKMPSLKSSESWTPLCLPAFNASGFLYAYILFVLPNVNVILLSTDQTHFHPLQMHVQNTLKPVVLAVMDQMASRPPRRDLMPLRFQPLLLHYFFQSDRTHEYICPEFQDCPMLDSPEWRIQLLRTYCTLHIRLHGSLKDERKLGYPLDSSTLPKATVYFTRTETMVALGLVKPNGFLYVCCQPLLSAEQANDLADNLWLFIVQDLLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WDR5</accession>
    <name>A0A6G0WDR5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Valine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="4">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Valyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">Ae201684_016134</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>tRNA(Val) + L-valine + ATP = L-valyl-tRNA(Val) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="4"/>
    <dbReference type="EMBL" id="VJMJ01000243">
        <property type="protein sequence ID" value="KAF0725363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WDR5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010172"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00817">
        <property type="entry name" value="ValRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000009">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000020">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000078">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000005">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="entry name" value="Valyl-tRNA synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02004">
        <property type="entry name" value="Val_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019499">
        <property type="entry name" value="Val-tRNA_synth_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004349">
        <property type="entry name" value="PRK05729.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946:SF109">
        <property type="entry name" value="VALINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="VALYL-TRNA SYNTHETASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10458">
        <property type="entry name" value="Val_tRNA-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 14" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="16">
        <location>
            <begin position="98"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="17">
        <location>
            <begin position="776"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="domain" description="Valyl-tRNA synthetase tRNA-binding arm" evidence="18">
        <location>
            <begin position="987"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="13"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00040837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF10458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAF0725363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1061" mass="119739" checksum="EB1130169EC181A0" modified="2020-08-12" version="1">MADQGASAVPPPERTDADGEPKLSKKMQKKAEKGKLKDVKEKDPNRWAPKEKKAEKPKPVKEVAPEEVYVNTTPEGEKKDLTAPMAAGYQPIAVESAWQAWWEKEGFFKCDDEKIKHAPKDKRFVMVIPPPNVTGSLHLGHALTVAVQDTLTRWHRMLGHATLWVPGTDHAGIATQSVVEKRLMKDEGKSRHDLGRDAFLDRVWEWKNEYETRIHHQFRKVGCSVDWDRAYFSMDERCSKATIQAFNQLFDEGLIYRATRMINWSCKLKTAISDIEVDYIDLEKRTKLSVPGHNPAFKYEFGVLTSFGYVVEGSDEQLIVATTRLETMLGDSAVAIHPEDTRYTHLHGKFVVHPFSGRRIPIICDAELVDMSFGTGAVKITPAHDPNDYECGKRHNLEFITVIDDDGKINPNGGEFAGMMRYDARVAVEKALTAKGLFHGKVDNKMRLGICSRSGDIVEPLVKPQWFVNCEQMAQDAMAAVRNKELTILPEQHEKTWFRWLENIRDWCISRQLWWGHRIPAYFATIKGEPFVDPNSESSTSRWFAGVSEADARDKAAKKLNVDPSSIELKQDEDVLDTWVSAGLFPFAVFGWPDNSQEFKDFYPTDLLETGYDILFFWVVRMVFMGQKLTGKLPFHTVYLHSIVRDKYGRKMSKSLGNVVDPLEVIAGCTLDTLLKKLESGNLPEKEIEKAKKGQMADFPQGIPECGADALRFGLLAYQQQVGDINLDIQRLVGYRNFCNKLWNATRFAMSHLEGGEFHDGLAATVLDNPVVNARDRFILSRLHNTIATANNALASYSFGEVTTALYHYWLYDVCDVYLELIKPVMSGDDAAAKLTAQQTLYICLEFGLRLLHPIMPFVTEELWQRLPGSRSKTSICISDYPEAHQFAKWANPEAEANMELIKEIIHAGRSLRAEYGLPNNARPTCFLKCEDAALKAVIETQIEDFCTLAKAGETKCLLDTAPPAGCAIHVLNDKLQLHILLSGLVDFANEISKLEKKLQKLLPSLTALEKKRAKDDYLTKVPENVREADDAKWEALNKEKDAITSAIDAFTKCQEAETKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WG60</accession>
    <name>A0A6G0WG60_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_015680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000229">
        <property type="protein sequence ID" value="KAF0726016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WG60"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001679"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0726016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="225" mass="24809" checksum="F17967807CB70731" modified="2020-08-12" version="1">MTSTWLEEALADALGFAETQDIATFIRSIEAQDEIYDAVVQMIGDERSDIAHKIAARLVDERTPQAPKESVPAAPKPRPPNASPITNCLECGLIEYHGQPTCASCQAPLHYVDERPEAQEARAHRDRLLANDASLSQRTVVHDMAAHFDQDKRDRDEAAASRSSTIHIDLVNRSIEAAPMASSQAQMLAHLVNDMERDLKKSNVRSTPSLVHVGHVDGTDADDYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WGE7</accession>
    <name>A0A6G0WGE7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_015609</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000227">
        <property type="protein sequence ID" value="KAF0726059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WGE7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003397"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0726059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="308" mass="34676" checksum="25B0D4649942438D" modified="2020-08-12" version="1">MDDGKRTHRPYSEKKRILALWEKERTIDGMTKVKFSRKMGTALSTFDKWCKNGEIICQMEDTDKKHLVTRPKKRCKYDKQKRPLDEREGLLYDWVQQAPQPINHKAMRARALELWPEYRDEKHPKCKTPGNFRKYCFRFAQRYSPCEDDNEDNTSHDSTPANAAAIDGLDNSQLAADETPATTPSIDEALAQAAADRAAAEAAARQAAQAAAVKAAADRDAAEILAAERIAEERTAAIRSAEARITAERAAAERIAAERAAAERIAAERADAERSATERDIADRAQLKVDDCMYQVHQVVAQEDYLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WGG9</accession>
    <name>A0A6G0WGG9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glycoside hydrolase family 5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_015529</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000223">
        <property type="protein sequence ID" value="KAF0726197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WGG9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017221"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35923:SF2">
        <property type="entry name" value="ENDOGLUCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35923">
        <property type="entry name" value="MAJOR EXTRACELLULAR ENDOGLUCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="5 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026236758" description="Glycoside hydrolase family 5 domain-containing protein" evidence="9">
        <location>
            <begin position="21"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="10">
        <location>
            <begin position="151"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="55"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="62"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0726197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="487" mass="52712" checksum="B8711FAF47994EA5" modified="2020-08-12" version="1">MKIAATIAIIASSIFGVTSAKELSVPTANAVVKATLVPMCASLAMSATRTRNGMLSVFPDQTPTTKPTTGTTKKPSTTVPTVKPTTTTAPSKTPTPSTTKATLAPTQSTVKPTASPVPPSSAPPSNGQLNFRATTDGILLNGSPFFFKGANYFGMEGDISVPHGLWGGGQSTTIQKIATLLKNNGFNAVRLPFAVDAVLSNKAIDPTKIVNEVALVNQFSGKTLSYFDVMDYTIKIFADNKIVVLLDAHVLTASSGITELWYTSSADQNNFENAWKIVATRYKDTWNVIGADLKNEPHGAATWGSGNSATDWNQAATKWGTTILQIAPRWLIFVEGIAQSSRDQAAYPTFWGENLMDVQRAPITLPVADRLVYSAHVYSSDVSNQPYFSASNYPDNMPSIWDLHFGFVNKKYGPLIMGEWGGKYLASSDIQWQNKFASYLQTNNIGFFYWSLNPNSGDTQGLLADDWNTPRTDKLKMLSIFKGTAIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WGH3</accession>
    <name>A0A6G0WGH3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_015453</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000220">
        <property type="protein sequence ID" value="KAF0726234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WGH3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012426"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.20">
        <property type="entry name" value="Activator of Hsp90 ATPase Aha1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036338">
        <property type="entry name" value="Aha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015310">
        <property type="entry name" value="AHSA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13009">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 HSP90 CO-CHAPERONE AHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13009:SF22">
        <property type="entry name" value="LD43819P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09229">
        <property type="entry name" value="Aha1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01000">
        <property type="entry name" value="Aha1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103111">
        <property type="entry name" value="Activator of Hsp90 ATPase, Aha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="7">
        <location>
            <begin position="41"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="78"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="79"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0726234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="305" mass="34372" checksum="877D0B7996592895" modified="2020-08-12" version="1">MSKRAGVDANDYSRFNNIVDSDEEDNSAKENVKPQAKAAPCRNCSKDGAKLKCSICKKAAYCNRQCQTSDWTFHRRTCKKPEDDKDKDVPAVKKPTTSDKPKAPRTEIVREDEEEDLEDARGYKNGLPYFHREQSQVEKELIGNIAPQKIQDTTAPAAITAPPKHDGSAWNHAGTFEERDTTTWCKDRLGELLRNLQVKSNGFTIKGGEIKDVRGESSICVVRGKKRFLFDFDFTIEWEVIGKSFKGKLVFKDIDNEGDNEITCRYDKSPSDATEAQQLSDAIKSGFQKEALARIGQFITEYNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WGS4</accession>
    <name>A0A6G0WGS4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_015446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000219">
        <property type="protein sequence ID" value="KAF0726331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WGS4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004635"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0726331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="195" mass="21360" checksum="264420A058B10DD5" modified="2020-08-12" version="1">MDAREEAYFAPTPVMEQESPIVIRQLRRSYSVTYAFVLLAVAGVTAATLVALATFKQANKPATNPVHHPPAIFSEQKVVSVTVPPSTTARVLPTQAYTPTENFGEIRFPAQVVEPPSRPSETPPASPSAFIPDCTDAIDSKANLHSGISIRALPVSHKELVRDVNFFRTAARLDNVTWDNNEATRMHTGARPVWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WH36</accession>
    <name>A0A6G0WH36_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_015296</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000215">
        <property type="protein sequence ID" value="KAF0726482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WH36"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004625"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="332"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0726482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="438" mass="48505" checksum="C2F8C214BE047A6F" modified="2020-08-12" version="1">MGCRQSTPVDEPQPVANVDWTNKSLSRIADHLEELEDIVPEHIVDKWEALTLKLDEKYRQDDKQTEETELEAEPAEPAEPTARDKEQVDKTTTPPSSLSTAEEEQISVEEEKPQPQAQQEETAQVAEVPTQPTSTEVVNQLVEEIVHDLLVQSIDNEATIETMPEMKVVVDENQADELEKDEIEVDIDAEIENDANNVPQDDVVDEPTTDAGISTDEIVVTAKVDDSNQVTDKSTEVDIDEVQETFESQGGNPAEEPTTQEIPVQDVPEAPLSETQAPNSVLSDTKEPFASKESISTDATDPIEETPLNENNHEPEVVKGIAWTPITMNSKLAAAQVSSFAIVGTTIEHGIVLYRVQVMPSGEILEKRFNDFKALYTALTHNKICELAPLPRAGMLSRFDRQNKALLEARSVAFDSMLASIARRPTAVQSADFQRFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WI96</accession>
    <name>A0A6G0WI96_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_014928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000204">
        <property type="protein sequence ID" value="KAF0726937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WI96"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003226"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0726937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="503" mass="58104" checksum="391D673C22E2A96D" modified="2020-08-12" version="1">MAKTSKPHSFKTSKDNKVKLLLAKIAAAWELENSSNSGEHRSTITQNDNWNGLLDRFLKEEEEIIHNPHLFRKRKTMKKNLARAAELLRDWKQRNKLSLTDGYTIKRHVNQVVHDLLVTPKAPHLPSTAWTAFGGICSNLFASMRADYGQNATLWVKKPLPALPQGREIAANWITSNLFSQIDMVMEHCLTPYTPNADCKTIHIPCQSSDLCQEEVSEMHVVNLRHQKSYHLTNYRQHAIRLPFKTAMKVAKGRFEKNIRGNPPKEVFKTSNPRNPIALLQVGSKYAKRVAGPNKQHILMRQFEENNLYCALSCCITRDECYPAANNATTKEWTSWTIVKARPDGTFTLIQIAVATGFQRNGGPFMPYDNYPMSDPNVQFDELIKHLKVHYTQEFAREAERNNLRIVDLYRDFESLIEEEEIYDEIRRIDFLQPAGAHVFHHTPETSAEASEDEDKHVHKRPRLESVTTDSEEVESIRVKREQRNDVFAAIEYLHQNYYPKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WIA4</accession>
    <name>A0A6G0WIA4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_014932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000204">
        <property type="protein sequence ID" value="KAF0726941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WIA4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004370"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0726941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="153" mass="16850" checksum="F5FB830ECD50BABC" modified="2020-08-12" version="1">MPPADLYVTALVKARGSSRLLAKILTPERIKTLGIWYQRVTPIIGTAIGFLMLVLILVDSISNNWAILDYCGNAVHFRTPVARVKTSDDLPSIYTFAKGYGIANLSNIGYWMNDFGIQNLAKSSPAVYFITAGSYTVGSMINFVARLPIRITM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WIL6</accession>
    <name>A0A6G0WIL6_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_014800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000202">
        <property type="protein sequence ID" value="KAF0727061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WIL6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001531"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0727061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="168" mass="18615" checksum="0AAE09770AF5A8C7" modified="2020-08-12" version="1">MTPTDHATGQLEFAHDDDASWSDFPLSRQTGQMDDEEALARALAGQFADDEALAQALAAQFEEELHLETDTDAALALQLAQEFALNDEPNDLPKTFQDHADESDEDDEDVRDYFEAFEAPTEACDDENEVPPDEGANAPAARGRSRRVSWFHQSSKSTLRSGVRIDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WIX9</accession>
    <name>A0A6G0WIX9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_014713</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000200">
        <property type="protein sequence ID" value="KAF0727183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WIX9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000100"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009836">
        <property type="entry name" value="GRDP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07173">
        <property type="entry name" value="GRDP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0727183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="597" mass="66841" checksum="230418CACF802AD6" modified="2020-08-12" version="1">MDTPIPTPAAIPAVVVVPAAPAVDVDKAEKVPTVQAILVDNLPRLEVDFLVKKAKAIGSDNWVWRQIVLHGQTLDVVRKGAIAETFSTVDCEINEIGAKVYQIVSRGDTRLTFCCPSETLYNKFATVFRASTTTAFWTFPPVVVLNDLVGVAKTIVETEDGLKASPVKAPSVPASNVTVAQVQAHLATLKAAYDEFPLFGSKEELYQYVQSIEADFIDALAAKQSKNFPPLVQQILKLFPEVVGEDGSMSSLTLQLDCTKCPNCLKPFSLSTQMNLHVGGKTLVCDQCENWTHYETFKLAQMRKEVPTFEFKIGIPLFQTKRTLPIPEIPRDGKAKTYMDRLWRIVFEDECITHHRVPYKAKFALEERIMACLNRLDLVQLIYRQLLFMGQIVAHYDYWNHPTVIQAAIHRYDKFRVVANAPKAQDLAATLDILLVGQTHQLTSSTAVLPVDKGSDSTTVRLGDTAFAWGEAFNEPYSSCALDLEGWIETKPGNEEVQHKFLRHQWKKFCRLPSRGNRFVGVQEIFAVESLIGYNADFTAEGLATAVSVIGSLEVDERIARGKFRNLLTPDASRVYTYRYAREVRSLFEKILAPGWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WIY3</accession>
    <name>A0A6G0WIY3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_014691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000200">
        <property type="protein sequence ID" value="KAF0727160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WIY3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014928"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0727160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="264" mass="27051" checksum="982F75C23357A7B7" modified="2020-08-12" version="1">MASLALAQDLSQDTSVMRSLSDNAVDAWAVVGDDRSLLYAAKPAPRGDAKTNPRGVPNPAPRGDAKPNIHGAAKPTPRGAAKPTPRGAAKPTPRGAAKPVARIAAPQSQRKPATPFKRYGAAKPADKKPAAKKTGAKDPEAKKRAKKPAAKKAGAKKAKDKKSVKKAGAKKAGAKKAKGKHGVKKAGAKKARGKKVVKKTGAKKARGKKGVKKTGAKKARGKNGVKKAGAKKARGKKAGAKKARGKKLVKKTGAKKARGKKAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJH2</accession>
    <name>A0A6G0WJH2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_014648</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000198">
        <property type="protein sequence ID" value="KAF0727390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJH2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017211"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019185">
        <property type="term" value="C:snRNA-activating protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042796">
        <property type="term" value="P:snRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000010">
        <property type="entry name" value="Transcriptional activator Myb isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051575">
        <property type="entry name" value="Myb-like_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621:SF1">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH myb-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="7">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="8">
        <location>
            <begin position="57"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="7">
        <location>
            <begin position="59"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="8">
        <location>
            <begin position="106"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="7">
        <location>
            <begin position="106"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="157"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0727390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="240" mass="27586" checksum="01AEE98E10AD3C9B" modified="2020-08-12" version="1">MSQANARNWLPEEDEKLRAAVAKYGARRWRVVSATFSQRSAQDCCDRWHELQTCHAKSKRPWLAFEDDLLLATVSRLGPKRWGLISSYIAGRNGKQCRERWHNHLNPSIKKGPWEPREDAVLREMQARYGNRWALITKALPGRTDNAIKNHWYSNIKPQVDKVQPTPPPPPSPPRKCPPLKLKSKANDGRKNAAMRAAEMKQEKVIPPPQVDEFAWVSEELNAVDATVWDNMVIYLSDVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WK73</accession>
    <name>A0A6G0WK73_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CobW/HypB/UreG nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_014458</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000193">
        <property type="protein sequence ID" value="KAF0727633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WK73"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020684"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05540">
        <property type="entry name" value="UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000208">
        <property type="entry name" value="Urease accessory protein UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01389">
        <property type="entry name" value="UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004400">
        <property type="entry name" value="UreG"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00101">
        <property type="entry name" value="ureG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31715">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31715:SF0">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW/HypB/UreG nucleotide-binding" evidence="7">
        <location>
            <begin position="95"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0727633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="291" mass="32068" checksum="38C9BCB983091849" modified="2020-08-12" version="1">MEHSHSHDHGHSHEHSHSHGHSHGHSHDHDHSHSHDHDGEEVVERFKLRFGRDPTPDEYRQLIEHGHTHEHLEHAGHYDERDPVLQRDFAERAFTVGIGGPVGSGKTALMLALCEALRDKFSIAAVTNDIFTKEDGEFLVRHNALPEERIRAVETGGCPHAAIREDISANLQACEDLSARFNLELVLVESGGDNLAANFSRELADYIIYVIDVAGGDKVPRKGGPGITQADLLVINKIDLAPYVGASLDVMARDAKLMRGDGPTVFAQVNARKQVDAIVDYVVAAYKQAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WKB4</accession>
    <name>A0A6G0WKB4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 18">tRNA-dihydrouridine(47) synthase [NAD(P)(+)]</fullName>
            <ecNumber evidence="18">1.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">tRNA-dihydrouridine synthase 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">Ae201684_014308</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>5,6-dihydrouridine(47) in tRNA + NAD(+) = uridine(47) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53364"/>
            <dbReference type="Rhea" id="RHEA-COMP:13539"/>
            <dbReference type="Rhea" id="RHEA-COMP:13540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.89"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:53366"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>5,6-dihydrouridine(47) in tRNA + NADP(+) = uridine(47) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53360"/>
            <dbReference type="Rhea" id="RHEA-COMP:13539"/>
            <dbReference type="Rhea" id="RHEA-COMP:13540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.89"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="16">
            <dbReference type="Rhea" id="RHEA:53362"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the dus family. Dus3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.-" evidence="18"/>
    <dbReference type="EMBL" id="VJMJ01000191">
        <property type="protein sequence ID" value="KAF0727683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WKB4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009158"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102265">
        <property type="term" value="F:tRNA-dihydrouridine47 synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45846">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45846:SF1">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25585">
        <property type="entry name" value="zf-CCCH_DUS3L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 18" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 18" id="KW-0288">FMN</keyword>
    <keyword evidence="7 17 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="12" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="11 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="9 17 18" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 17 18" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="20">
        <location>
            <begin position="89"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="20">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="17">
        <location>
            <begin position="89"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="17">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="27"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="48"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU291113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAF0727683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="608" mass="68473" checksum="9EFD397416E1B1D0" modified="2020-08-12" version="1">MHASSLQVALSKFEFYWQLHPYRTPMEDTKEETTVAPVEQVEEPTEEMTLRKGEAPIKPEFRKPIETKDDGEERERGTFKKRPRDPTEDPSTMLCRGIAAGEGCPFEDKCKFSHDIADFLKRRPKDLGDTCPVFAATGYCRYGLNCCYGMSHVDANQANLGSPAEAKVIEVNDLSNANRDLLRKNKYPFRTAPSTYKKKGGQGKKNRDFQIEPVTITDVPEHKPVDFKGKVYVGPLTTVGNLPFRRVLKQWGADITCGEMAMTTNLLQGQQSEWALLRRHESEDVFGVQIAGAYGDQVARVTELITRETSVDFIDINMGCPIDLVCKAGAGAALMNRPPRLCEVVSGALTGIELGSFGLSKRPGLTVKMRTGWSEKQPVAHKLVSKVQACRSSNEFMNQSVVLNYAMRTNVHVDAMTIHGRSRLQRYSKNADWIYVQECAGTRESEPHMSMLGGGDVLSYEEFHQHLSSGVLDTCMLARGALIKPWLPTEIKERRHIDISASERLDILKDFVKFGLEHWGSDQKGINRTRRYLLEWQSFLCRYIPVGILEKLPQKINDRPGPYYGRNDLETLMASDQAVDWIKISEMLLGPVPEGFQFVPKHKANAYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WKZ0</accession>
    <name>A0A6G0WKZ0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_014148</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000185">
        <property type="protein sequence ID" value="KAF0727921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WKZ0"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0727921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="159" mass="18126" checksum="57EDE8B629FA9ACD" modified="2020-08-12" version="1">MSEARQLQSHMQAAVLDMVRLYNLTLPTAENSYLYQSLNWTLFDTPLQGRLIRRRDISYVEVCALPLLSPLKSTCSIKKSLKSKGEKHYILSMTSTEIPGVDDLEHKYGIVRGELLHSGFLFIETDRPGVQEFLSMHHNRPNEDPPLKNGLSTIVQRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WL08</accession>
    <name>A0A6G0WL08_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_014072</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000184">
        <property type="protein sequence ID" value="KAF0727961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004183"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="612"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="23"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="274"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="364"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="48"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="287"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="364"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0727961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1460" mass="163419" checksum="8AA0F7B8BF6E8706" modified="2020-08-12" version="1">MKTQIAQDADAIRARDAELQRIRTDAENQRQARLVAERRAEQAESRSPMFSNSQQLSPVQTPITSPPQAGSDTPTTATRQPTLKPPNLTKFKIEKFSAKETYAGLGTDFDPWLHRFHDEIEMDIASNQTHWTESHKYMALKKSLDDSPARFVLAQENSWKAAVPSGETFSFNHLVERLRDAYTTHLDVDQLMAKMRMEKRYAHTWNEHVEYLRHIQRQIGAPDSLVLSMFTKYACPELKTTLVASVIKISQNDTRELDKAVNTLVTLTGTAVNYGKKGKGPVHGQANLATTTNSSNGSQNDRRNNAKNHQSRGKTNIRISEAAVEALDATVLNELALPAGMRGISHRRALSEEPTDWNRRYRKYQQTQATPNTSTATRLTPPTQTSGLTQPRGAFGLLASGENDWEANWIHRSPSAPANLAMGDAHHSQSNNAHVEMWILDSGCSHHLVANPAYLENPRPSSLRIRVANNECVNAELVGTVLLDLNDTGEQIILGEVHYIPGLSANLLSVSSMVRKGFTITFDEAEAVIKYGTHIISRTREHDKLWGGERGKHFHWHIALGHLNKAAVIKLARDSTPENMVITRSEHDLKLPCLECAVGKQSRSKQPVVDTSASAPTDEIGAVIASDVAGKTTPSDRYGNKYYVNNVDYGSGFVTTYAIKRKSEQAAKAMEFLAEFETSFTVKVKVFRSDRGGEYLSEKFRTFLAKRGIRHELTEKDTSASNGKAERMHRTLLNATRTMIFGSDLPSKFWSHALSYATYLRNRVPSKSNADMLSPLAILTGKQPCLSHALPFGSICTVRIEPRSKGIERRAEIGRILGVNSQTKAYDVWVARLGKVVVSRDVQNISRPRNRLVSEADLPPVMEIISDLSGETLTHSIDKQLNQQREMCAKLDKLRSNHERSAPEPRRSDRIHAIQLAKGGHVALVMTFVDPKTPNEALSGPNADKWRDAMQLEVDSLIGNGTWELVDRPPNTNIVSNKWVFKVKYDSERDVEKFKARLVARGFSQRYGVDYTETFSPVIKQQSVRLLLALGLRFNVDVIHMDVLQAYVKAGLDTEIYMEIPALVPGDPETQALRLLKSLYGLKQSGRMWHADIDATLLEIGLKKSLLDPCLYHSWSEHGITLLGLYVDDIMALSQDEAFLQEIKNELESKYQVISFGCVKRILGINVHRKDGSMFLEQTSLIEELLEKQGMSDCHAQSTPLSLDHKMTEPGEPAKMTQSTMREIVGSLQWLAGCARPDISFATSLLSRFLNAPNEHHENIIKRILRYLSGTKHFGLEIKPTPSKEMNVSTDADWAGDKSNRKSTTGFIVEVCGAIVHWFSKQQPTVALSTMEAEYIAACVGTQEALWIQQIMAEIGLERKDEPVSLWCDNQSAIRNMSNDILASRAKHMDIKYRFVRDAVQKGRIVVGYFGTDEMPADGLTKALSVERFEEARKMLHVVSRNESLAMDALTMEFHIEEGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WLX3</accession>
    <name>A0A6G0WLX3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_013842</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000179">
        <property type="protein sequence ID" value="KAF0728291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WLX3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008500"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0728291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="688" mass="77961" checksum="D781C40A6527A3EA" modified="2020-08-12" version="1">MPELSYVVLGEDQSGSVEFAATDTVANVKHRINELEKSTFPARQLQLYRVNGLIESEPGKYQLNGNPFDLSAIHRLSDFEKQTAVTLTRNTDPASIFLQSDGSAESPWRIHCLVVPPCQSKPREPERKRLCLRVGVRDHMTSIDDFEFDCTAALQQIPFPSLSAPPSCFRVVNGAFNYQRRGDLETIYDEVLDHWNKGDGMPINVVGTLGYGVSHILAALAFRLLKEREQLKAAIESTGAVSFVLYIPDCQLLKSPSLAQTFMQQAVLLNCPDYQGPLHSTQEIAKALSRYDILLIADEWSSIDDSTPESLEAKKLLDAYLLGNTVVKVRGMTASSLNRHTGGGYRPHGIHIHWFGGFSDAEYQEWLAHQSQQVRELYFQHPQNFRLWTGLVPLWLFEFSRLYQAGDTLDGLVEKVVDGDVSRQVHSRMATFYAKMDPKKIWQVYTSLPVVYPSLLRNDLKPWIDGRFFYEDIFTGWLVPSGGILLPMLFQVWRANVANDSMLQVWPDRLEEVKDRRQCECLVKSVLKAKVLCDGIAGVYSKPFDRSILPFSFQPGTEATSFVKAKWLAQTASHPKSKLPWILMDPDVFNCGVNVTIAGPPSDMTEFFQVWKSIAQENSLTMESGRIVLDDTFVRRKRKTSIVLLKDVHHELWSSILELACFKNFPDTKSNQRRRSARASSKSKIRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WM03</accession>
    <name>A0A6G0WM03_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Core-binding (CB) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_013735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000178">
        <property type="protein sequence ID" value="KAF0728370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WM03"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005456"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00397">
        <property type="entry name" value="DNA_BRE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0728370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="467" mass="54040" checksum="646CE0352252D473" modified="2020-08-12" version="1">MEQATPCKQTIEQSFLGASTRRTYASYQRQFEEFCKHEKDGIDPASATAEICTDYFHHLFSLGRKARTVDTAKTALVAYFKDHKIDPNPAQETTSKKRVAKSPSLSIHDLSKLIDAFAPMNHFVATMLRLLFSASYLGCFRISEVLSLKWCDVDFSKTGEERFVSVRLRWHKKASVEKDYQIYHLLNEASYLCLRVFDFYEEYVKLVRLTIHNIPNGAYVFPQTTAVNGGLRVDWFKQAAQMRLRRILTNTVEATPGLPLGITLHSMRRGGAFYRVFESPERRFNFRELMAWCRWEDIKTCCEYLVTKNISDAIDPRLLLHKRSTNQFVVAGDQLTSTVDIEALADTIIRAILEALPTQNVKPKTPVQKTMHEYLAQKAIPTARNGEEAWQQWFTPDPQNDLFIAMKDFPKDSVKLDRRKYSERLTLSTAFAKFQCYDQFERAYDGFTRTYSGLLKEVRKRKREGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WP06</accession>
    <name>A0A6G0WP06_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_013203</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000169">
        <property type="protein sequence ID" value="KAF0729066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WP06"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017714"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="HNH nuclease" evidence="2">
        <location>
            <begin position="28"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0729066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="275" mass="32387" checksum="471C3160E748A3A3" modified="2020-08-12" version="1">MSDRSPNFKANLCLYYDCHRRKKTWIRCILLDISFPASLVTAAHLFRRSNEYLAFPMMQISDIDDERNGLLLSKPLKVAFDHFQISFIYNHSNDCFYLKLFDQSIRNTRLVDAMRNAKQKQVLMNAVSRAKRPCKFDMKTTFGHLDGKALKFRSPGRPFKRCLNLQARLAYAKALKKQDIDPSYNFDDFWSEGFSLDKMTLFRQSIANSGFLLRMHCLFSCWTFDSALKKRKECVESKFKTSYRAREGDISMLITLIMVDCWMEERWASIRQYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WP47</accession>
    <name>A0A6G0WP47_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ER membrane protein complex subunit 7 beta-sandwich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_013143</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000167">
        <property type="protein sequence ID" value="KAF0729166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WP47"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011581"/>
    <dbReference type="OrthoDB" id="27095at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019008">
        <property type="entry name" value="Beta_sandwich_EMC7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039163">
        <property type="entry name" value="EMC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13605">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13605:SF4">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09430">
        <property type="entry name" value="EMC7_beta-sandw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026330945" description="ER membrane protein complex subunit 7 beta-sandwich domain-containing protein" evidence="7">
        <location>
            <begin position="20"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="ER membrane protein complex subunit 7 beta-sandwich" evidence="8">
        <location>
            <begin position="45"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0729166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="207" mass="22679" checksum="85131C59B025B9C1" modified="2020-08-12" version="1">MAMWFALWSVVCAAASVLGANIEGRIAYPANVPAPASEDGSLPVHQVVLDGGVRSTLSTRDGRFVFYDVPAGRYTVDIYSTTHMFSQFKVDISATNEIRVLEFKYPGTPKLAVSHPLVVDAHAKIEYFVPREKFSVLDLIRNPSFLALVVPLVMIWILPRLSENMLDPEEYKQAQEEMAAVGDPQAMLKGLFGGAAAGESKDDEDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WQ41</accession>
    <name>A0A6G0WQ41_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_012792</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000163">
        <property type="protein sequence ID" value="KAF0729524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WQ41"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016187"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051826">
        <property type="entry name" value="E3_ubiquitin-ligase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765:SF434">
        <property type="entry name" value="GB|AAD18119.1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765">
        <property type="entry name" value="RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="2">
        <location>
            <begin position="181"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0729524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="225" mass="25652" checksum="73705E023930809F" modified="2020-08-12" version="1">MPKLENVRLATSGSALVGATFTGSSQISTGDEAVQVTGAVQSNIMLDDFNITFYTIRIKSPVTKALWMIRWRYSQAYANRKHLLKMAEACPQPLHDQVVALLKRFPRRRLGLDNEFVIMDRAEGLKIYVLALMKIQELCMEYKETAVVALKTEIEVTLKLPAVYHVDAFQWKDAPSCDPMCSICLEDMQENESCVRLRCEHTFHMACVSEWLRRDVSCPLCREQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WQI2</accession>
    <name>A0A6G0WQI2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_012734</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000162">
        <property type="protein sequence ID" value="KAF0729673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WQI2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_005237"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007498"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01100">
        <property type="entry name" value="APPLE_Factor_XI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000177">
        <property type="entry name" value="Apple"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00223">
        <property type="entry name" value="APPLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026005998" description="Apple domain-containing protein" evidence="5">
        <location>
            <begin position="17"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="6">
        <location>
            <begin position="257"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0729673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="501" mass="54697" checksum="D0FB84B95A246E15" modified="2020-08-12" version="1">MRRFFTLGALAALALAATDPSDAELEKELAAWEASPNGQYAKQLGLVPKTESITGQSDTSEKLRRWKAKKAMLPIYAARNPHASFTMNTPFALVTKDEANRRLDADIDWTTSGCIHPVQNQGACGSCWAFAATATIEAANCLAGRGLVKLSEQDLVSCSGAAASGYPALAIDYAARNGVCLLKDYPYISGGDGTVHDCVSSCTKQNVNVDTYVYVYGESSYLSVMQAQPVAVFLYAGEEFMAYKGRTAGFTQSSSQCSTLQTNTDYYGYDIKSTQRASADLCCDDCKNTPGCQLFVWFQGTCYLKNAKGAQSTKPGATAGFVNFSGPTCGAVEANTDYPGQDLYTARLQCLQLDARRLLLLEIVASKPNSQVWRDVGSCQQMLSSRARRRLRPEAVLGFEPQNESQGWLHSWNNGQLVVPNPNWVCDRATKMRQNIPNKDILILSGGGTDYDSCKLINFFQCPAVDVVSIHTYADANLNVLQQFVDLTNQYNERVVVEEFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WQZ7</accession>
    <name>A0A6G0WQZ7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_012702</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000161">
        <property type="protein sequence ID" value="KAF0729814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WQZ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020472"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="530"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="550"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="567"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="379"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="485"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0729814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="589" mass="65857" checksum="D667709636F95F22" modified="2020-08-12" version="1">MFSELKPPKSPIDETDIARWETTLTNQQIAISNLQQSLQLQAKEQQRFSEKLQTLAENRAADFHRILHEVQVLTRAHEENRVATQQQLNQSELTLVDLSSSNRNLGDLVIGLTKENSLLSERLRSFEGLLEQRETKSTPESVQSPSSVEPPPATPVSDITHQLLLDLQSALVRMESEMSDIKVSLDTSINSQAFGRAVKYTTVPTSDEQAHCEFFIQQLVDQAKLCHLSDEECKLLLGLKLTSDKVHPALNQWWIAYSKTKSGDVWTEIYDNFKDRFCNRTQRELVDRLFEESERAEGESVKAYAIRLQTILDDIDVPDHQGVVIFKRGVRHARAESCLDNTDKELTSISDCMKLLRTRQIRLDDPPVYQERLKSKPASASTNTTSSRTTYSDVSTTSTPEQSPRPTRKSSEVGFRDQATLEGILEVMKTTQSNQQAFVAQIQHLTEALNKPPNPYFAAPVQHAMNFPYGYPPPYAHGLPPTAPQQPTTNTPASSSSQHATQPQSKPRPAPTPVMISSKPDDCTTSGAKVCGRCDRLGHGSVDCPRKFARCTTCHQIGHYAGEHAKSCSFCKQIGHTYSRCPSKPADKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WRC7</accession>
    <name>A0A6G0WRC7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_012472</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000158">
        <property type="protein sequence ID" value="KAF0729983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WRC7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014048"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF37">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="9">
        <location>
            <begin position="305"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase RNase H-like" evidence="10">
        <location>
            <begin position="560"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0729983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="797" mass="90819" checksum="180F4D2726921821" modified="2020-08-12" version="1">MMAQVRKSRKAFGLVRRVLSSASGDSVATLNGRLDVPFCADTGSDENIISLKTIKDLQALDPTVDVEDLATPWKGCAVDDQPVYAKQVAKLRVQLHTKAGRVNLPGLQSCYVINSSDDFIISRGALESIGIDMNRLLEQVAEHQSLEDGDDVGESDEGDDITFGVEIRHVRGNLAELDREDRAAAEDLVQDAIVELKKSSEDDEKEIATLWKVVLEAANGGVWRAKFRGTDEPADVPAMRIKLKPNYSLTVAKSARPTRSKRSFLKRLADSLKATALFLRTPRPSGKKLLKASGEWTQEELLLYYRLTIDYRTINSMTVAMAGAMPFQFMVLESVRDAKFLGIFDLTKGFWQLPLAKDSQEILSFMLAFRVMTPTRVMQGHCDSASFFQNTMTECLRPLLYKHCLVWIDDILVWANSLADYVDVLRQLFAICEKHRLRLNPAKSTLLCHEIKWCGRIIDGNGVRQDPERMEALCNIPYPTDAGQLQQFICAVNWVRDSLIGFAQAVHPLQKRLTQALEGKKRRKRIASSIAINLTDEEKSSWNDVKDLLRSSVQLCHPDESATMCLFTDASKDGWSIVVTQVREFDEEIPVHEQQHEMLVCQSGMFDKTQMNWSVIEKEGYPIARACDSLKYLLLRPLGFRMYCDHKNLIHVFAPNAELKTHTRDKLLRWADIISQYRYEIEHIDGVHNLWADLMSRRGQPAPMKSHVNRLRVDEPPCFAETSISRRTSRRYARALKQWTKRRKRQSHNFVYKPPQAKFRPLDDPEFIWPDTDSIIDAQQRHTAPRTAILHDDGKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WRN7</accession>
    <name>A0A6G0WRN7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_012375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000156">
        <property type="protein sequence ID" value="KAF0730079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WRN7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003322"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0730079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="240" mass="28123" checksum="64AB0342BCD9A9C7" modified="2020-08-12" version="1">MKGDDETRLLAQKWIIQQAYHSTERAFAPIAFPETMEPFIQVDVGANEQDEFFFINTMTHCVLPYALEHVSDALWVTERRFLKYHRDGILPTTNELKAILSETLCYGREVDLSVLRVNITKNSLRGQIRDHDRTTIIFRTIVHDEAFPLEDNNSTVNLKEWMVADRLGPSLTRLRTFYTMNHPATDHGYIPMELLATEFNIPRDGYMNQRVRDHLRASHSRQRETFYEHLTKMLHLIASM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WRW0</accession>
    <name>A0A6G0WRW0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_012221</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000155">
        <property type="protein sequence ID" value="KAF0730218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WRW0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014159"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
        <property type="entry name" value="FYVE_like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43102:SF2">
        <property type="entry name" value="GAF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43102">
        <property type="entry name" value="SLR1143 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="5">
        <location>
            <begin position="27"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0730218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="154" mass="17002" checksum="9876F119923FEEF6" modified="2020-08-12" version="1">MRRIDRNLRENRLIKTPFLSGEQFVELSSRQRCYLCKRNFGFFRKKKHCSKCGEVVCSQCGPKWHIKVAGTPVKVRACTTCSLLSRSSIGMETETAMSTIITPSSAASTDVWRLADGEDASDDDGESSFVSFIICHITASAPAVGQLLITSLMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WSV8</accession>
    <name>A0A6G0WSV8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Transcription elongation factor S-II</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_011949</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000153">
        <property type="protein sequence ID" value="KAF0730526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WSV8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015893"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00183">
        <property type="entry name" value="TFIIS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13749">
        <property type="entry name" value="Zn-ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.30">
        <property type="entry name" value="Transcription elongation factor S-II, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035100">
        <property type="entry name" value="TF_IIS-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003617">
        <property type="entry name" value="TFIIS/CRSP70_N_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003618">
        <property type="entry name" value="TFIIS_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036575">
        <property type="entry name" value="TFIIS_cen_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477:SF0">
        <property type="entry name" value="IP08861P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477">
        <property type="entry name" value="TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07500">
        <property type="entry name" value="TFIIS_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006704">
        <property type="entry name" value="TF_IIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00510">
        <property type="entry name" value="TFS2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00509">
        <property type="entry name" value="TFS2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46942">
        <property type="entry name" value="Elongation factor TFIIS domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51321">
        <property type="entry name" value="TFIIS_CENTRAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="10">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS central" evidence="11">
        <location>
            <begin position="140"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS-type" evidence="9">
        <location>
            <begin position="275"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="83"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0730526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="35709" checksum="583D3B6DADADB9E6" modified="2020-08-12" version="1">MDDVVNINKRLTKFLVGEDNDQNGVADAMDRLQKVDMTINILKDTKIGQTIAKLRKHEAELVASKAKDLLKKWKALASRPSDSDIKVDTDAKSEPGIPKPRVSPTTSETSVKETPKRASLPVFNRGGPAFEFIPKGLQEVRATVRRKLKEILDLADEELRGESEIIAVSIEVAMAKEYKMDSARNTNEGKKEYTNKYRQLSFNLKKNAVLRQELLLHTISGDQLIKMTPDELATEERKKEMDQLRDDAFQRARLDWAEANADKINKVCGIKDPRGLFTCGRCKSTNTSNTQQQTRSADEPMTVFVICHDCGKRWKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WTF3</accession>
    <name>A0A6G0WTF3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_011828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000151">
        <property type="protein sequence ID" value="KAF0730713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WTF3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000878"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0730713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="522" mass="59595" checksum="821997AA134CF951" modified="2020-08-12" version="1">MTRVHGLNETPLPRRRVVWHKPMAFLSLLIAFNVATMLMKAYLNAIRWLQNYYTPELLAEQGRLYSDRANGTTVLHWPIHRNVSELTTFPGAFFYGFGIRQALMQFLEAKENETFGRCQHVLFLSSRLGEFCVWINPPTETDTSDEIQVFQALVNWQQSSFLWIKLAVRIVLTAYVCRELAVYYNNYNILATNFIKVGLSNKSIVKIQIYVGDPTCVILSNVWVSLVFVLDFWFSIDSVGEALLAISQVHDLPAFLLAILYCSRSVWFAYFSMRASIIVIKRFHLEHYFQPIDPTMVAIAAVVYTATLMILSTTTPLMHVEYLLWDVTLSEAAQLEAIDTFPITTGITLALGAIPIIFSVGAKLYHSRSKRQVQRGPSAKLFAQPSRRTSLVIYNDLKQRMAFKILGLGRLFNDTDSVGGSLYKLHERNPAYNLMPLFSYRGSDCFVACYMSNGQVDSRMRLTLWRCLDCMEKNQDQAIHVCKTEHDNCLSRLDATPCATFFPRHPSALCIHIGKDKSPWIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WTJ8</accession>
    <name>A0A6G0WTJ8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_011898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000151">
        <property type="protein sequence ID" value="KAF0730790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WTJ8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014455"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22754:SF32">
        <property type="entry name" value="DISCO-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22754">
        <property type="entry name" value="DISCO-INTERACTING PROTEIN 2 DIP2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="48"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0730790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="592" mass="65746" checksum="CE556C65759FBD15" modified="2020-08-12" version="1">MRRCYLLPQPQPQKIHPYTPAQTPRFLVGLPPLTYAQKPCVESISDWLVQDTGASIVLTNSKYRNLIKLGAVKAFLKKPKRTIAWPAHIAWLKTDKLKIALKSTKAATTTQPSDVAFIQYTSGSTEEPRPAMVTHANIHAQGLLWDWCASDDLVLGWLPPYHDNGLLAFNLMPIYCGNKSVQMSPLAFIKDPSIWMRMASKYKAGYTCGPNFAYLLAAKRTADNVAATLDLTKLRNAACGAEPIKPDYLALFASKFAAAGFVPSQFNCALGMAEATLVVTGYPDPATRGGPKALTVDRTILEKDHPFEILDDLKDDGKAIHLTGLGYFGRTYDLKIVDPTTRRVLPDGRVGEIWIHGPSMVQNYWNRPELSQARLQATIPSEREPSKGYFRTNDYGVLVDGELFFVGRIPDMIAMDGRWISPQTIESSVERATDCIRPGCVSCFTLPRHDNDEGRESVFDEDEDPALVVVAELKQDMNTATNGQAIVATLCKSILRQIWSENHVQATTIVLLQPKSIPKTTSGKLQRWRAKQMFFDKQLKVQCAYSHTVRSVNKKNAATLKDIENALATKRFTPILLLDPASPMPSPIVQSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WUV2</accession>
    <name>A0A6G0WUV2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_011496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000146">
        <property type="protein sequence ID" value="KAF0731236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WUV2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011603"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0731236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="620" mass="71281" checksum="40F6F641999797BD" modified="2020-08-12" version="1">MMIRSASRYGIGAIRSLVLQDSWKRFCTAQLVKRKLRVVASLDGEEELGLEDVSSLNTAFDQMTLKRHRKSPPVEYTVPRRLVVVPRERKLKSKRTLHEKNPSKPKTTKEDVRKAYRLQRVESLKTFVNQKDYDNAIITFNELPLQAWTPRAYLHVMKAHTALGNFDAIVSLFESAEQAQLHLSNPMRLHYVLALNKLLCHDQVIDSFSKWHEAKVNLSVPILNAVLAACSHTKNWAVSKQVIESTRLPLEGTSYFHVLATALQDTENCTPEEVLSLAEAAAAKGYPITVTILNKILLAAAQTDSRHAVRLSMQLWMSSKHYGALKAGSIEFYFEIALQQLWKKKRYDESIQLFDDLIHLPSATYQFKARIAKDMLVRVASSDVDTSIQLLELMQEHKLGPLSAATCHQLYDGWFKQKKRPRQIAELFDKYSAVTLGWTDTRVSSMIVWGYKQYASGEYVNARLEYQKLMDLLEFTFEESNSLTYVAISYIVRWLYDMGKSAEALATVKAMIDNPSLNLGYRVTELGMFLAWREKEPELVIQLFEGLEVRLSKIKEFRPKRFMVKLASRAYEAVGNLEKFQEMSYILTNEEYRVWNGSRVDDLEQYHKTNNTTYVTSKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WW01</accession>
    <name>A0A6G0WW01_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_011027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000140">
        <property type="protein sequence ID" value="KAF0731723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WW01"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013527"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="104"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="331"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0731723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="474" mass="53770" checksum="23BDFA4F667C0223" modified="2020-08-12" version="1">MVDSTLDELAARPRCRPTTFKQSAAAKVAKTSAMDNNLHVMDVSVETIVALQADLSAKSKELLWKTVLLTKLELTLQHADARAAESQVELDRAFVENAKQTLLVEELDTQLKAMTEANHAMQNELVQAQTDRKTLTERCMKLTRQVEKEQASREQSDAECIAWRQKCSALDLERAKLIHSHQQELMDCRRQLDNAQFELHQLACRTKPPSAAVNAPTSSCSAQTTFHWDELEMERMGQARQQDLLTIAALNQSLSLLEAQTTALEASKASLEKSWKKLRDKAKTWKGLVALAFRRNEAMRKEHAHAIFERERLVESKRVFAKEYLYVTTQLQTLQETLAQANRQLEQDQVLLTESKKREKSLGRTLRTREARARELLVTLQSTQSKLDKIQQVHDKTKAHSKQLATQSSHYHAAFQKEKAEHEQALQEIEEFRAALIACCQSVVSLETIQPPSTSWSLEHLQAVTGITEPLVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WWC5</accession>
    <name>A0A6G0WWC5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Inositol polyphosphate-related phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_011126</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000140">
        <property type="protein sequence ID" value="KAF0731828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WWC5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010549"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF275">
        <property type="entry name" value="LD06095P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="3">
        <location>
            <begin position="390"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0731828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1042" mass="115835" checksum="860DC3BD7C8E6118" modified="2020-08-12" version="1">MTEGRAWIPGRPLGQSELVAIDWSVRTSSTLSALGCLFILFRSYFRPKHERDVSTMLVAALAGIELVSSMVKLPALQFVDLVFDSSDHDYKISPNQTRSKETMCQVQGYLLDVLSLHAVLWNGCMAFNLLRWVVYRDAEEKLESRFWIYFFATSFFCVLWGVTGAIPMWRDDDGPRGTLFGFSRYFCWMRFPNSILYRYIPFVALTLVFIVAVVVHVRRVVLHRARRFSMSPASEGLVSSIQRRLCLYVCVFVCLYTPAIIYRILEAAVESSDKDTWHDHGSNKGQGNRSWHRNSTAASGNITFADGSRQGHDHDHDHAHATGLQVFGIIAQVLINLQGFIIAVLSHQKKSPPRKNSIAMSSLENTPSVFLEEMHSSRSGLSRTNSGVKESVSIFASTFNMAEGGVPDADALHKWIPAGHDVYVIGVQECLNVLAMRQAIATHLQVIHGKMFVEYGREIGRRETKLGFHGHIAVTVYVAVDEVQEGHFHMHLEAISKVHRGVNLIGLGRASNKGAVGFAFRFLNTTFAVVNCHLASDPSTKKSKLKKRHQDGSNILSGMHLQSIDNEFDCHLMAHHTIFMGDLNYRLSARDASAEKILRIIATAVNSNVEIRSSRQTTQATSEPTKPWLDAMILQPTGHEMLCLESDGLYVLTNSPQALPRQPLGPIVATDPLLGSDVMPSPFSTSSTPSAEEMTWMTLLEHDELKRSMADGVVFHEFDEARISFAPTYRRVLGKAMDMTNELTLAQVSQLYTTVLGDGKVRIPSYTDRILFHSLPGLRDRMTCLQYWSTECIGMSDHKPVSSVFRVVVDKPLSPLKAAAAASPHHHVPLCASPRSLRAQLPINLFTVQFSKLNVQWGPSLETYMSESDEDSINSTHMVVSKDEPFDSIASDVSRATTASASPTKADLALDVLRVRSVFPLPCEDEFAEERRLVELADHLLFTSNARGKLKPTWKLSVWRVLAQNGLKQTVVLPKDCSRRQLHVALSFVLPSGDSAGQCVISLADASRRPGRKVDFAVALTVGGRRTGELTGKLTFAVDKTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WXF2</accession>
    <name>A0A6G0WXF2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_010551</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000135">
        <property type="protein sequence ID" value="KAF0732259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WXF2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018619"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="486"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="282"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0732259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="549" mass="60447" checksum="BA0CD8F7514F232C" modified="2020-08-12" version="1">MALYKSLETDVTSFFISQGSLFESIVNSLSTRLTAVESHQQTLLKANQSLISSDSNKLLDQAIRHCTAAKQDLHAKINQKLDGIDAELSRINHALESLFQSVGRAQHTCAVNHRQQEAATSALAAQCEQMQHAITSVQSSVADFDDLGNQWKNQIACGFSETELVGLANELSTLSQVETCHDAAVNSKQAIKHILDAVSGDSLDPPVDAVADLQKCLDELNLQVRDVASDPNTPEDHLDSLAHAMTSLPQQLRRVQWSMWGTIHRVDQVCLKRNNTSEIAISNALSAQIEQLQADLNKFTQRERQLELQLAACPSQEDVLHQLNALQAKLQADLSTEAALSSIDDLKAQLRGLPTNDVIQSLERALHEKADKAVVDRLEMNQQQGDAETAHLGLTKVPLKCLSCDQYLPKHQVQIHQTPTTSLAGKPAPTVSPRHVLKPLEASKRSHQTPLVRPRSSNLHGPKEHFSMHFVQDHVTRLIPPEESQAIKTKGSKASIEKPPRPQSCVPRTITLAFQLPEAPPISNSQSVTDFKKYSFYSTANPSTPNQFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WYJ0</accession>
    <name>A0A6G0WYJ0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_010331</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000130">
        <property type="protein sequence ID" value="KAF0732623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WYJ0"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0732623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="119" mass="13098" checksum="F3166F38543CE92F" modified="2020-08-12" version="1">MPSSRCVHYRGDTRLKVDSIDWTTPPIALDQSKRCCGHAVGNQRRRGGVCALRPSPSQAFCESKRCCGRAAGDTHHTPTTPFFLSVLCRIQRCVLGTSDQDSSPKQLGRDSFVAFSCRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WYY4</accession>
    <name>A0A6G0WYY4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_010154</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000128">
        <property type="protein sequence ID" value="KAF0732825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WYY4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001352"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="46"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="188"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="271"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="399"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0732825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="666" mass="78067" checksum="2D045BB81ADC5F2C" modified="2020-08-12" version="1">MNSNPSGVGGVGTPDPSNASRNGQYDYLLQQIVQLNTDLHKTVAMSQSLKAERDSLHELTERLKQDVIRSEEKCDKMQEVLMTETEFKVQSDRKHEQLVHKWKQQLEAKAKEFELLQRNLAPPKDLDQLRLAIQDEVEMPHRQRVQSLQLEIDKYREMFYNVRREYEILKTEHEQTIVNHGNELESTMATHEILINDLKRRVDAAEERAEATHMVEKVRRLEQDKDNFLLENHKLRHELEQVRQAKLDQFQRHEVEMTKTATQLAEMLAMKTNVDLELKAAQRQMQRTKEDNERLLGTIDGKEKKLREALDETMRLREQVKQKDLLLVDNHAVHTAKLRDLRAELDNDKMHFKEKQLEWMDQVSTLQASMQQMEASFQKREKEWQMDQARFQSLQAQDAMHAKDTIAALETKLAEKIAELNAAQEALDDHTQRTTQALEQEQLKVHRLQGEKESLTAKLTTMQELVTKLKTENMTWRNQHKEMEQEYRVLQAKHRDAMQAQQESQSVVDQYKAKMQYLEDDLTKLTDVRTSEKEEFDRATTLLRRQMDEMTAAAQSTQQTLKDELKQSVDKLSKALAKAERKRDAYKEKCFQVHGRFKAALQAKEAVESQLNQVKEQHHVEVQHLLTQWSHLEEAKTTAMVGKALDPELNSFLAEVDQYTQARLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WZ24</accession>
    <name>A0A6G0WZ24_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_010175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000128">
        <property type="protein sequence ID" value="KAF0732846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WZ24"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018695"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0732846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="646" mass="73259" checksum="6AD20F3F9F86BBC8" modified="2020-08-12" version="1">MSSEAAYSAATNVSVTDFSVQALINAGLDIDVSVSLQFSFIIVVTVFVICFEYVLESIEHVIARHPTYWTLLNKMYRELLVGGLTAFVAKRLDQWDAIAKYDQAKLNISDDIVLYFSLSIAIQSAIMFMMLRVRNEKVDKLSVLSARDLLEYMSTDDGANPWSQFSKSIMTTKILQNFFLTTYKLPDVFSFPKYVRSIQDSEIFSLFDVEIIEWILLVAVYTIFFWIAEDFESIRFIEEDATDDIIEAGIDVEHAKMILATRLEVLLVYILILTIALWALYAYVRRRVHDIVLHASNGRKSYLEALEDIANKEDARLAKPMTNDEAIAVMMEFADSLTDVEDHSSIWDLIKSGARRLVGRAHAKDKSHMQVANLHLPFFSRKAVHVFAKLLLSFNAMYFALIWSAFNASVVPVIKSKQATWYPLSLLGLMAILVFNMLFFAPQLVRHLALVNATVRVNPHELKAVIEHFSDVLEMQTDMADAIVTYCDAHGKDIKDLEHDIVAMDPQATGYIEGEALRDIISHYGFKFSANKFQTFVCLQFKTRGTRVPYADFFRVLYGLTEQLTSQHDSLSELLSGKNLHSEYLNSLRRDRPSESFLSGTTSSHGQRRPNHAMLFKLSAINQFNAKDNAESQAKVSPRKVAAVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X0F0</accession>
    <name>A0A6G0X0F0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_009575</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000122">
        <property type="protein sequence ID" value="KAF0733325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X0F0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013170"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029760">
        <property type="entry name" value="GPX_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592:SF78">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00763">
        <property type="entry name" value="GLUTATHIONE_PEROXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 4" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0733325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="182" mass="20659" checksum="3B327A342B22D326" modified="2020-08-12" version="1">MSRWSLFGRRASSQSSGDDPTKAKSFFELSAVDMAGQTVPMSKYSLTQLNYTQLAALDAKYRNQGLEILAFPCNQFGGQEPGTNEKIMEFVKTFGITFQFFNKCDVNGDNTVPVFQYLKHHLSGLLGNFIKWNFTKFLVDREGQPFKRYSPQTAPNDFEGDIVELLSKQAPREESKEEAKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X0Q4</accession>
    <name>A0A6G0X0Q4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_009616</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000122">
        <property type="protein sequence ID" value="KAF0733367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X0Q4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009102"/>
    <dbReference type="OrthoDB" id="1913277at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039205">
        <property type="entry name" value="NDUFA11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21382:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21382">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0733367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="145" mass="15157" checksum="899C53E1DEA0B5F5" modified="2020-08-12" version="1">MDSLTSQQKVALFTGAGAFGGAALGSVESVWSIPKAGGVFPSFGTQLHRIGARSIAFSSAGFLFAAGEGFAHSVRSHDDIWNPFIGGLVAGIVPAVVKQNAVWGLGAGVAIGTAMAVAHYFESGEHESPLEKWSNRYEYLNAKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X1I7</accession>
    <name>A0A6G0X1I7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DOMON domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_009295</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000119">
        <property type="protein sequence ID" value="KAF0733723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X1I7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012326"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09631">
        <property type="entry name" value="DOMON_DOH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045266">
        <property type="entry name" value="DOH_DOMON"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050369">
        <property type="entry name" value="RBOH/FRE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972:SF69">
        <property type="entry name" value="FERRIC REDUCTION OXIDASE 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972">
        <property type="entry name" value="NADPH OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50836">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="7">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0733723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="643" mass="70267" checksum="5423776AB59E1F23" modified="2020-08-12" version="1">MFLRSLVNATSVCIQVLFQPTSTVQWTSIAIAPTPYMVNSPVNNAVVFDSASAITSLFLMQSYESRNMPAQSDKSSITAINGNVTNGLISFTFERTLAAKTIYDVEIEPNTPVFIQWAYASRRWPAKHSDYGSVYFLLGASSAEAAIADDGTVQTATPGITAITFGVIVILGLVATHFGRHWHAIHHATLLAPRKDRRSLAFFTDTLTDLKVGEAIVILVYSWGLIAAGVRAQTTFSSLSAGHRFCMISGHVALVALVFLLLPVARGHHWELIFGTSHERVLKFHRWLGAICSVASAIHLVGNAANGSVGSSQVYGVQQVMPIFGLLAFFCFGTMSLSALEPIRRHHYNTFYYFHRVASVLGLIFVLLHSKTVQYAMILPLVIYVLSGLFRLRAFFNRFDASIKVHGTNTVLLKLPVTPQTTKWATTANPCAFFWVNVPSVSRLEWHPFTAIVTSDGQSIAFCMKAPTPNGFVAKVVLQAIQATDSGKLSIVVGGPYGTPALDVNNYANLVLIAGGIGVTPMVNLINQFRHSQSKTLLHLVWVVRKPEELLAVEDVMFPLPHNVKATFYASQASARQGSLIHSGGDDVVYTQGKPKLDEILNTSRFTNQSVGVLACGPPGLVREAQSFCHNCGFDFHKEIFTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X461</accession>
    <name>A0A6G0X461_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_008730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000109">
        <property type="protein sequence ID" value="KAF0734659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X461"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010102"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0734659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="45131" checksum="DD49725C5F0A8FA7" modified="2020-08-12" version="1">MTGVDLGDDGVLAAVDVLRVGLEIENIGERVPSSKKRLSWRFVFADSEEVHTVTLEHSRVSFKKRVRLDGKRIGASEVYTSGPWSFDFTVETHPFVPFQILIKDLNSLGLLERARANLNPDILYAFYANGKVWESLSDRSLKYENQLGSVRWSSITYCRRVHFTVDVNEHKDVRVSWLFTFGQDGAVHQLMLEDCADGSKILVLDRTSLRHDQPTDDALTLDLIDSSPSKKEAWMAQHLIGEEEHELVVRVLNDRQGEAKYTLHINGCAWEDMAETDYVLQPGFYPVHSKSTGKVYYREDATKQTMWEKPIQPRKASSAATLPPQNSASSISQQGQPVVEDLVKSVDLLDFSNDSFGFGPTTTPPPPTDVAPKNETSTTIASPNPTASATDKPVVQQAAPIDLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X470</accession>
    <name>A0A6G0X470_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_008700</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Mitochondrial ribosome (mitoribosome) assembly factor. Binds at the interface of the head and body domains of the mitochondrial small ribosomal subunit (mt-SSU), occluding the mRNA channel and preventing compaction of the head domain towards the body. Probable inactive methyltransferase: retains the characteristic folding and ability to bind S-adenosyl-L-methionine, but it probably lost its methyltransferase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000109">
        <property type="protein sequence ID" value="KAF0734622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X470"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002841"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052571">
        <property type="entry name" value="Mt_RNA_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015324">
        <property type="entry name" value="Ribosomal_Rsm22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13184">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13184:SF5">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09243">
        <property type="entry name" value="Rsm22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="416"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="417"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="431"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0734622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="447" mass="51035" checksum="98CEAB21DABF7A93" modified="2020-08-12" version="1">MMLARRSFWNSAKAALTKGKDTVKRISKINETADVAQDLASIGLNQTHVFPELLRQRVSTLVKERTQGQLEKLKETITLGTSKSRFPWDSHNEEIGWEMDKKPKIPEFLYGPQETLAFLAFEMDGVYSSLHHVFRQMDKSFKPKSMLDFGAGPGTASWVAKEFYDKSLNEYRLVEPSQSMVDAAQVTMEGFRGLSFRKSLSEMKREIAKGKQYDLIVVSFVLSEITNDFERIAIVSTLWSLLADKGRLVFVDRGNSWGSLQVRSARQFILDSLTTNADNLAASDDVSPRIQGGRILGPCPHHRECPMKEGEWCHFAQRSPKVVQPRLPTTQRWAGYGSMKFSYLVLEKSKEFDSEESEAPSTLARLTRGPILSTRHVTLDLCLPKGELERRIVTKGRAVREVYRAARKAHWGSQWPADKDTYELPKVEHPPKRRKRKPKTRRRTTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X5L3</accession>
    <name>A0A6G0X5L3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_008193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000100">
        <property type="protein sequence ID" value="KAF0735278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X5L3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017891"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0735278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="320" mass="35587" checksum="C990E6B5BFA534AC" modified="2020-08-12" version="1">MSVTLQVKNEAHSVQLQFDAHDSIAAVKAAYQKSGKVLGRADYIVLLHKGKELQDEKSIAEHGISDGAVLVHIETLHEPFHGVNYELLADAIKQRRMHEQANVRMMQQDNIWAAGEDGTVHQLGFDKSIISRMSAKPTAPPPAKASGRTFFNQMSVLVNGCSYHVLPSMEGRWNGELTSIPSQEEGTQVCSSELVYREEGVWHLRQMRTSISGLTTTQYSWIKPAADGILKLETDDPSLRGADITMQEVGLNILIITGTSKRTGRPVFVETITSIDNARRMRTVQRFDESGGFRSVFVMNEKRVVDAVSGALERYDTNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X6I7</accession>
    <name>A0A6G0X6I7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_008125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000098">
        <property type="protein sequence ID" value="KAF0735439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X6I7"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0735439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="97" mass="11148" checksum="0C098E1F07F8CD1A" modified="2020-08-12" version="1">MRRDKDSQPSEVQSSHEDHAAHRTIFVHATTFPLRIRFVHPVGFKCDIGPPLWRLRFEMSTQQRKSLSVHRFRPDDLGCAMVFPQLEQLPSSSSGSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X6T7</accession>
    <name>A0A6G0X6T7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_007923</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000094">
        <property type="protein sequence ID" value="KAF0735603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X6T7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012713"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13365">
        <property type="entry name" value="Trypsin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="359"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0735603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="884" mass="101397" checksum="DE115A5DD7AF28B8" modified="2020-08-12" version="1">MVMEEEQMASKMIQRMVRARLARNQFRRILTEVYSKVYDKKTKQVRYVDNRTGIASETKPILLLLLQCKGQERSDPLLPEDAAIRIQHCVRTRQARLHLKELVRDLYQKHLDPETKEYYYLNTQTKQISHTKPVFLGDEDIPVERFIYRSAACRLSTKANMIGNGVLIQFHNVLCILTDHVTLPDQETARFSRVQFNHRQGSIAFLVRLRSDLFFITSTFASYQCDADPSLDFSICAIDADEFRKAAGDSVEPIQIAFTDRRMACAQDRRHEEIEIVGHPHGKLAQVHRGFVAKCIPNMVKPKRLEYQNEFPSGASGSPIFNFGGRLLGIHHQPTLKDAANQCSLVKPIIEFTKAQIQPPVPLLLSSCLTHDTVNIYWQVPPQYKPWNGLQLEFTLEMCNRTLRGTKGYYDRFRVVYTGPKTTFTVLGLIPATKYSFRCRSVHFMAKGNWCAPMQISTLPAATRAWQVEYCSSITAAVEYMTKSKDPLVHRQSIQWLQARAVEITPSSDTWTSEIEPELMACHTGSIIRQSLEMFRHLDDHAFDCLDVLGHFAQFQTIFRSQMVDVDTFEWLVHHLFPHYSSVPRVIEKAMAFLGYLVKDNGLFDPFSKSVQGIPIVLERIEQYLTVEGVVREACYVLAAACHNFRPSQLQIGVNLGMKVIARVFLAFPYHPQVLYWACLTLGNAACGYEPNQIRGQKYKIVDCIVAMKIKFILKLNALGDAIEKETNILETLAATAIGEEVRNEMDLHELRRQSLIAIQSFMKSENVLGVANYALEYMMNDQQKQIQARTKHLATRLVSIRLSAALIHWQNQTNKVFMGRMLHRVLGGMAAKLLYSALRKWEQSMRELRMEQSTLAYRANKGLILDLRKSKKAERYRLLVQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X9H0</accession>
    <name>A0A6G0X9H0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Plastocyanin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_007118</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000088">
        <property type="protein sequence ID" value="KAF0736668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X9H0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004067"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13844">
        <property type="entry name" value="CuRO_1_BOD_CotA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48267:SF1">
        <property type="entry name" value="BILIRUBIN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48267">
        <property type="entry name" value="CUPREDOXIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026074231" description="Plastocyanin-like domain-containing protein" evidence="7">
        <location>
            <begin position="18"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="565"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="601"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="666"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="760"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="790"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="822"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="854"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="885"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="134"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="428"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0736668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="908" mass="98319" checksum="E31B32900DB4A30B" modified="2020-08-12" version="1">MFGPLSLVTLVLATAQAQDAVTSKEKLFDQWKAFTTPLVIPDVIDMRKGGNLEMNIGETIHAWGSGSPNGTTYGYGKVGGKITTPGPTILVKKDVPIDVTWINAISSNQHLLDLSVESTLLIRESSCYPNCGVPVITHVHGLENPAKYDGLPHSSIYRSQNYSAHYNNTQSGSTKMYHDHAIGLGRLNMWSGLIGLYIIQDEEVEAKYNLSKLVDIPLLIQDKIIYPDGTLVYSSVSTCQTEGTKWVSEAFGAVNTVNGVVMPYVEVPAAQVRFRIANMANARHYNFSFPFADQCKLIATDSGFVGQPEAVNGTEFVVFPLERMELVCDFTSVAPGTTYDLSDTPSADSAYSYDPRVLQIRVVAASATTTKVEIPAKMTAFKDLQALYKSTNGKLRTITLSEMEGPNACPTQLMVVQHQMVANVSTIQNKLMCTLGKVEKWQFKNPTDDAHPFHWHLVNAQCGPDDNSINKNGLKDVVVIPNEPKSQRITQVCYVACTPDQFLIEGSTVGPTDYGFSTDEPYLAHCHIMEHEENSMMAWFQLMKTDDDAPIDDGTVVDPNKATAAVIWCAMGMSVLGGLATCLSVLVLSIKRLNFLAGDKALAVTFALSSGVMIFIALVDLFLESIEKFNNTLAVGGTVDLELIEEGLAPPGASAPVCDKTCHGKAYLAVVGCFFGGVMIIVLLEFIIHRVFDFHAKRLGAQLAANQVAERVDIGAPAEDGELIVKTPIARPEEYNELTNEDDTLTEESQEERRTELGRAGVLTGIAIAIHNFPEGLALFVASLQGLRSGIVLAIGIILHNFPEGVAIAAPVYYATKSYKQALFWTSLSGISQPLGALVGWATISGGMSDTTTGILYAMVAGMLVCIAVKELVPGAFKFGPKVFTVSFFAGFFIMAVSVVLLKFMGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X9L2</accession>
    <name>A0A6G0X9L2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_007111</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="VJMJ01000088">
        <property type="protein sequence ID" value="KAF0736661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X9L2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016951"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048857">
        <property type="entry name" value="OTU1_Ubl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21403">
        <property type="entry name" value="OTU1_UBXL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="OTU1 Ubl" evidence="8">
        <location>
            <begin position="4"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="134"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="409"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="142"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="413"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="430"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0736661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="630" mass="68793" checksum="846927F042B0C493" modified="2020-08-12" version="1">MLSVRVRSPKGVAVVQIAPSSSFKEFQEKALAAVSLSASSSFTYRAGFPPKEIDATPDTPVEQIFQNQDTVVIEPQNMSTRVSRPKKGKFTGSGVGVMLGAPSTAPAAPQPSVEPNVAGKPKAVIKVTPNRKRFQGTGVKLSDSTPTTAPAISSNTSVPATTGGAPSSASTLEPKRRRTMINLGSKEDVEIKLVQAVSGGGSTKTDKFFRKATKTAVAYQYDTALANTRLKAAWANKFIIQMVDARQMKVRFMDGVRTWKEEIVDCLQPTELRTAIQYAVLDGDKEMLKPFNMAQCSPRVFWSLARLYNGDVGAGLAALLPHEDWSFLDTRTRTLSAKALESLATGGGRWRKEEEELPDETAPVPIVPVQHNHEEMAKKAEEEARARTVDLRALRNATARAALARLHQPSMPPSATAVTPTTAQKVSKNDEEDGEKEEDETLTVFCDDCGKARIVAVADKDRVNLQDDEEDKPWTCANLAAIDRSSGCAAPDDELVCAVDSIATAATLDALQVTRRLELANANAEELFSKWRRQFPTQTTSLDRIEALIQEARFQQLDDCMQEILAQAPSGTFQVLEAAKVATPYDLSATPVDLLWREVEGVSLEEVQGWQTAAKQAMEISPWMEQWRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0X9W2</accession>
    <name>A0A6G0X9W2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_007050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000087">
        <property type="protein sequence ID" value="KAF0736896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0X9W2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006371"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0736896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="317" mass="33867" checksum="43E836D47C735C1F" modified="2020-08-12" version="1">MDAETLAFMLSSYHHFSNERRERTMMLNLRVVALLLLVLASGSHGYRRQLLRSEDIETLSPAPRATGALNLSPTTTVAPVESPKPEPALSTPSPLPSLQTPSPAGNETTSSPSPAVSAPPQPTMTATVTPLPNTFLPPTLSSAIVLVLFNLTNASTTMVTTSNPSIQATVPMHDATSTAVPQAQQSQTMSASQIAGIALGCFVVGLLVAYLVYFLCTRRLKDCECGDTDVSPWIDSPWDTLVTRTKLSNREVSVSYAGLSTARLLQTIGTAQQSEHSSRGSVGIDSTRYGDLIHAVSMINLSESNILREGSYPDCHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XA17</accession>
    <name>A0A6G0XA17_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_007034</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000087">
        <property type="protein sequence ID" value="KAF0736880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XA17"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017817"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070740">
        <property type="term" value="F:tubulin-glutamic acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241:SF147">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE TTLL7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="399"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0736880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="675" mass="76549" checksum="564628723FF3AB70" modified="2020-08-12" version="1">MSSEKSRKSKRPPKEKKIKINMTLAKYEVIKKIARDRGWKQITDDSDKSALASCNLHWIDVPDFLNTFKTMLPFQKVNHFPGMSNLARKSKLARNFQRMSKLFPQEYDFCPKTWILPFDYTDFAQQFNSDGTSSRTFILKPDHSCQGRGVFLTKNLKDVNKTDIFVAQRYVAHPLLIGGKKFDLRIYVMISSCSPLRVYLFQDGLVRMCTADYTVPNAENMEQKFMHLTNYAINKHSNNFEKNKDDDGEGSKRSLKWFFSWLGEQYDKSDIDKLWHGIGDICLKAILSVQPTLSQEYQSTFAKFTRKSTDGVDPSCMPNTARANAASSCFAILGMDVLVDENLKPWLLEVNHLPSFGCDSPLDWNIKERLLNQALDIMHISATDKETYDMEQSKSLHRRLYAKSSSGSEDNNRAAAEDDTDGPETQSEDAKTARALSKSELTETLEHFYKLVNPEKPKSDIDAIVVKFVENQEELHKSLVVKYGRGIFDDVNVAKPGDEETDEDDEEELIDFVRLYPPPVPTPQNAIYKQILDACQNNIDEQLLRLTAPLHQKKGEDLSRTTLPPIMKGGSKRELGRDCFGYTGTDKVRDLEVKEKKPLPMPGPAQSAAAARLMMGHSSQKLSVLVPTRPASQNNAINPVKKAPVQYGLEYRERLEGMKNKPTLAMTQITFGGFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XAC8</accession>
    <name>A0A6G0XAC8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_006886</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000085">
        <property type="protein sequence ID" value="KAF0737082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XAC8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021136"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0737082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="491" mass="56869" checksum="E4D960F7023769CB" modified="2020-08-12" version="1">MNFLPYFGEDPERVLCQASSQIKLGGKAVAKTIEKLLGRDVSAKRKDRRTMQASQVPSYKLSPEYVKTCKQLYRPLESNGCMAINQLQSTFERQGLRINSAKLNAWLQRPRTHGDDYITFGEFLDACFTLYGPSLSSNVQIQDADASPSGTTAQALFRHVHPFDDMVERNKQALEFSYAHHGKQNPIEAQMRQDALTRSQSMVTMDTPYPSIRRVSSEQELREIDEKERSKKAIKVIQQRERAAAIRDKQNANIHTANNFSSSVGMVARHIQIGEINEKRQYRQQQQKLYIKHRKEIDKESRDEMDAFNSRLKLLKMHDMHKMKTQLHDQLAFELQKKEFREEMIRRRKDPFTISDSTCTLQRRPPELLAALAGVQTPSQQKRLARAERRYFDQSRSQQLRDYKHDKEFAKPSRYVPAPIVNVDRQDPDTAWHNQETELSDAMNALFDEWVRDQKDLSLLVPTSNSPPAALRYYGSIKQLPACPFMSSTQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XAW7</accession>
    <name>A0A6G0XAW7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_006407</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XAW7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010124"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0737230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="993" mass="108878" checksum="AF129F510D405FC9" modified="2020-08-12" version="1">MLTLIVTTSDLVEDLKAMGVKEHLEQIEIHSQHEKAMTTAVLNLLGYSVDLSEAFVGDLMKFCDVTDDKDLRAALMAKMLATLEMGVVTDDVILQVVIPRLVHEAARDLAYVNEIIQCLQKVSGFPAFVACTSAPSILLRLYVDDFNAFSPQNQDITMDLLMLLCKNRTSPIAFAFFDKTWNALSNLFALAASLYVCNVHATSRILTFAWLVTAPDADMMLLLASQASILTPLCRVLCDPPPPMEKKLESIGKPSQVTHVLIVRFLHAISIQPLGPAEMVECSPIFEALVACLSSYPIDPVQKRRDGQFSYLKDLQQIALQYANHVQSSTFALDTGLKNLVQAVEALSPNHALVPILCGFLADLTQQKPIVTAFYRLQCLDNFVHMFGRLQSADAPTERHIHLLACLAHTSRAGLESEVITRLASDANYTSTLLQCLNQCTRQAQEHAAYLLSTLILYRPELGGSPGFVSLLVESLEAVDLVVVRRVLVCLSCVLQVEGTQETLLRHATVPVLAQVLHKADAEATEHALRVLAVLCSKHAAICRRVVAANLLGVMTSMLRNAQIHEHNSLHAAWILSCVTKDKDLALRLQGSEPSFALECIKYIDKYSPPTASKILRMALNSWSVCSTELPVVGLVHKLMAFAPVSENRSVRKNGCRVLALLFVLPDLDDDSVGDDVVDRLVHYFFDMLRSGEDKLIVASLQALENGLRVESTTDRSIRAFVANSSDGLASVLHLLAAEAYHPSLNQLLLVVKFLNGLVEDDVSTDITSRLENMAVSPLLKLFEQDPLAQFNPQTIKEVLGLLAALTRRNTTLALSPRIINSIKRVIELLNHDEDTTFQSEALHVLVNFASVADLRQSIVLHGGLLVLVGALEHDLGDSQLQLILLGVALLSGDDLAKQTVDFSALVPKLLNLVSSHNTNIQSLAVWIVSNVCVVDSVRQAINAKNGATVLQSLLYQVNNTSSSTERPLSSSKRIREMAPKAIKELGFTPHCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XBC7</accession>
    <name>A0A6G0XBC7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_006586</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000084">
        <property type="protein sequence ID" value="KAF0737422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XBC7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011194"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0737422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="161" mass="17901" checksum="AC01B3306BF4F609" modified="2020-08-12" version="1">MTMDPIFAQRAAEAGRVTLGYAAAFLFNIVIQVRGKVVSIQKFKKAKAAGLTKEAYNRYTCDIMLAADRSVGNFVEWQGIFLSLFWTNAVVAGGKEIWLGWVYVATRFLYPILAHSGGTKKSGITPLITVATVPGYYVLLRYMYLIYQDLFANETAVLPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XC95</accession>
    <name>A0A6G0XC95_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_006247</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="VJMJ01000081">
        <property type="protein sequence ID" value="KAF0737753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XC95"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017926"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020161"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13975">
        <property type="entry name" value="gag-asp_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="9">
        <location>
            <begin position="1059"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="40"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="866"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="868"/>
            <end position="879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0737753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1205" mass="134823" checksum="308BBCDC887EA8C0" modified="2020-08-12" version="1">MVLGHAKQMRRSTKSKQRLQYQSTHIARIGWADVNPYSVLDDEDAYPSDPPGPDLLDESDDESDDTPTYHVAPVQTSIAHIPSSASRIITHPPVAWDDLPIAYPEDELSPIQATKQKVRTLRNYHRRCAKRDPRYNDDLFTDCPGSRRFIARIQPLCHTRPLNGPDPFVKAYVNGTKATTLIDTGATSSFISATFWHHLGRPTLTRPKSNFVSADSSNLEMLGRATFKVCIAGRTVDFPFWVMSTALTDCIVGIDLLRYLGAVINLRDNTLTLEDGDRLLSLDPLPESHTTQHPMGYALVATTTVPPRSVTWVPCQAGTDLPRSSTILLEPSKKTLLHVAAALYTTQPTIYVEVINPSESPIVLHTAAPIGTWTALPQEFDERSPMGPTVSETDVSVATSLSSVPCSIASKDEQPKRVLTASGAPGVVCPVQTTNQPIKELPIDWVDSSLSVEQRELLRKTLLDFADIFVDTSKAPGRTHLVEFSIDTGDSAPIRSAPYRTSKAEDDIMEAEINQYQDLGLIRPSKSPWASPVLMIRKPDGSIRFCIDYRRLNKVTVKDSYPMPRIDDFLDVLGRAKLFSTMDIASGYWNVPMAKESIEKTAFTCNANGAGPQYLSSGTSSLLPNPEKIKSVLRIKPLKDVAEVRAFLGLASYFRRFVKDFAEIAAPLTALLSVDTFTWTPECDRALDTLKRRLVSPPVLAHPDFDLPFSIWVDASHIAVGAVLMQKQQGKNRVIAYASQSLSKAQAKWINKDSGISEIECYGVVWATRKFRPYIDRRHFTLYTDHEALTWLFNTGTRSGNHKLARWAMELQGLDYTVVHKPGELNGAADGLSRLACPILTRSRTRHAQTSLDNDGARAMEEAILTQRQHHHSSSRARSARFNTPDPPTRDLEPRGKGPSTNSTVELFNARGRPTAILYNEQRSDPEISAIRAYLEDGAVPLDPRLHKPVTRNGHQFTIRQGIVCRFVTIETPLRNSELVVVPMIPGSMIEEVLRTSHCSPFAGHLGFNKTRERIRRTAYWTDWMQDCKDFVIMCPDCNKAKGGRPLRQGPMQRMPIYDLKGPFDLMVVDALGPLPTTENGNKYILLFGDYFTRWIEAFPVPDLKTSTFTGTLIDEVLCRFGVPTRLLSDRGSNFISELAETMYTTLGIHKLTSAPYHPQSQGLVERFNHTIIQMLKIFVNDHHTDWDTYLPRLLFAYRTSYQEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XCY5</accession>
    <name>A0A6G0XCY5_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">KIF-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_005968</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0737972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XCY5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017936"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053248">
        <property type="entry name" value="Zinc_finger_MYND_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46533">
        <property type="entry name" value="ZINC FINGER MYND DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46533:SF1">
        <property type="entry name" value="ZINC FINGER MYND DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0737972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="31050" checksum="4EBAE6E7DD28E7FE" modified="2020-08-12" version="1">MTQSPLKSPTRSSDHTGASSSSASQAAKESALLATKARCEEQMIARDYQAAYATIVDGVRDAVELYGKSALAMVPYYLCMAEVGLELSHMNQVEEVLALSVWNLVRASEEDAANEIHTLGHRARVCKMYGRYHSECEHFDEAVKQAANGVYYSSLIHGPEHIETSTLYFTLGVIFQKMFRTEEALGMFDKVVEIWYKHLMSISNQASSDENVERDRVATPPIEDKLCHEGITILAHVYETRAKILGETHIATGEAQYTKVDHRLSLPFIKPSKILPNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XDS2</accession>
    <name>A0A6G0XDS2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_006129</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000079">
        <property type="protein sequence ID" value="KAF0738149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XDS2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004989"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050529">
        <property type="entry name" value="CYP450_sterol_14alpha_dmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF2">
        <property type="entry name" value="24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026231686" description="Cytochrome P450" evidence="6">
        <location>
            <begin position="24"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="418"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0738149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="479" mass="52921" checksum="B72651630A22DFA3" modified="2020-08-12" version="1">MGDAISLLLAFLVGSLGLVAVSALMTRRPKAADSGIPFISSWVPYFGASWHFRRGRIAALLAWTREYGPVFSFTMLGQPVTCVTDASLFGPVIKSAALILQPLKTKILNRVFGASNPIDSLALASLAALTRKNVLVQLSGTSLSQWSTKSHQLFRAKVAACLEQDASTQVEVYPWLAHHVFTTMMETFYGPELASAQFEADLDALDSAFTALYMGIPAKWKKVDAPRNRLLLALEDYVTKNIDQVSPLARDRWQGCQEHDLPPRDQAAHQLNMIWAMTFNTVRTAFWLLYYLQHTPNAWTAVASEIREHVNPEEWSTVSLQVQLQRCPLLDSAVKETLRLTMSSGFMRVAVDAAAMELGNGITLKVQPGDQVVLQAGVPFHDPKQCPDPSEFHVDRFMHMSPDLAKDFRPFGLGKFQCPGQFFATEVVKMSLATLVLETEISQFQGTVGADYSSPGSFAVKDIHAVRMNIRRSLSAVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XDW9</accession>
    <name>A0A6G0XDW9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ankyrin repeat-containing domain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_005788</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000076">
        <property type="protein sequence ID" value="KAF0738351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XDW9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015378"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052050">
        <property type="entry name" value="SecEffector_AnkRepeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586:SF3">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0738351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="37096" checksum="5DCF0C6DF6FD9A6A" modified="2020-08-12" version="1">MAKRQRSQSEVSSSRVLRSLELRPLIFQYQDGIYYEFLSLHQSMKPFRLARRGCLHPMRVEELPDDHIEIIHNLLSTCYASQKSLIKMLHSMEYMRSFVAHHVVFTGNVAIAEQLDEAFGIAQFPGPLIDIAARRGHFAMVQFLHEHGHPGCSTDAMDSTALTGDMEILLYLHTHRSEGCSTDAMDDAAACGNLEIVQFLHNHRYEGCTVEAMDRAATGGHLRVVEFLHFHRTEGCTTNALDGAAANGRMDVVRFLSEHRQEGCTRRALKAAARRGDLAMVKYLHGRSVQGLTYAELQETCSMTRDASVLDYLAQISVLPCSDDDMMSDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XDX2</accession>
    <name>A0A6G0XDX2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_005663</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000074">
        <property type="protein sequence ID" value="KAF0738432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XDX2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014642"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827:SF1">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0738432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="195" mass="22150" checksum="9DDC9BB98750E1B1" modified="2020-08-12" version="1">MTKCFFNDCESPVLPGSWKCYIHRRRGRCLVDNCAHQVYARRLCVRHGGRSQCQHENCTMNQRVGNFCWRHATTKLKKTCSHPGCGKQAHARGKCVRHGGGRLCKAPNCSMHARHGAYCTRHSHSQTIADINNWANAVSTLYVQFDQDLDTWTEDLLASTGSVKPLVDDICGQNLLDPKVIEEVELMPLYHLFYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XE62</accession>
    <name>A0A6G0XE62_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_005860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000077">
        <property type="protein sequence ID" value="KAF0738302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XE62"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003199"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0738302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="283" mass="32288" checksum="FB68E7F13686A441" modified="2020-08-12" version="1">MDYIFVDWGLTTHHLHSSVYEANRYCGDHLAHTTTLATVIPTTPSKNQPSTWRLPWELLLNPHKVKAIKCEAQSLLDDFLEEPECNAGAKWLGWLCRMKRKMKQGQFNRQRHRQELLTIPRRCYVKAKSDLRAGLVEPEVFQTTRDRYTDAKAEQRQSSLDRGFDCHATLNESATAHFLRKPPALKVPITSALKHGVIITNQEEVANVFTSHWRSIMVLPATTPSPDPVLQKTVINHATALLSTDQRRAFDRPICAAELCSVIKAMRKNKSPRLNGWLVVFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XFD2</accession>
    <name>A0A6G0XFD2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_005465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000070">
        <property type="protein sequence ID" value="KAF0738855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XFD2"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0738855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="116" mass="13665" checksum="E42094AE4BB29D5C" modified="2020-08-12" version="1">MPRKGPPKSTRREEREKERQREADARRREEMKAQRAEEALRQFQRRAEMPDSKAAQRDLRRGLEAQGDRLERYGESPAQRAARGVIMEKSDSDVGRRIPRGFIMDEFDDYGDDDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XFH2</accession>
    <name>A0A6G0XFH2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Guanylate cyclase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_005504</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000070">
        <property type="protein sequence ID" value="KAF0738895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XFH2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003250"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF335">
        <property type="entry name" value="GUANYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="7">
        <location>
            <begin position="223"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0738895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="449" mass="49809" checksum="F19BF1C515B28433" modified="2020-08-12" version="1">MDDSMRRRQEALMAYNILDTPPEDSFRELVTLAALTCRTPVSCISLIDWDGRRLWIKATQGLTESASVSFDDITPATMFCAQCVRGGDITDGGTFEAPLIIDNAFEHPLYADNPLVQQRSIGFYCGAPITAPNGIPIGTICVADSKPRTLTSDQIQTLTLLARQVMDHLEHRRQNFMLINAVAERETFRHRLREILDDMLPSHVIDSLRHGVKPPPDYFDPVTVFFSDVVGFTDICASIPPTAVMQILDTLYSHFDRLVAKYNLFKVETIGDAFVCCAGIPHEQPDHTLRIAKFAVEAMEAATKVPIDPEDPSKGCISIRVGFHTGPIVASVVGTTQPRYCLFGETVNTAMAMETSSHAMRINMSREAALALLDQCPEARIEERDVKSVDRQLEMFFLEPESVMDQDIMPIPPSPRCPTPTDAETLTCPSAFELWQSGLPWATAVGDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XFM3</accession>
    <name>A0A6G0XFM3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable imidazolonepropionase</fullName>
            <ecNumber evidence="4">3.5.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_005181</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-imidazolone-5-propanoate + H2O = N-formimidoyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23660"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58928"/>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
            <dbReference type="EC" id="3.5.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. HutI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.7" evidence="4"/>
    <dbReference type="EMBL" id="VJMJ01000067">
        <property type="protein sequence ID" value="KAF0738991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XFM3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000494"/>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00551"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050480">
        <property type="term" value="F:imidazolonepropionase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:L-histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:L-histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01296">
        <property type="entry name" value="Imidazolone-5PH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Imidazolonepropionase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HutI"/>
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        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
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        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01224">
        <property type="entry name" value="hutI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42752">
        <property type="entry name" value="IMIDAZOLONEPROPIONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42752:SF1">
        <property type="entry name" value="IMIDAZOLONEPROPIONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="11">
        <location>
            <begin position="81"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0738991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="430" mass="46790" checksum="A97B93A883A31A30" modified="2020-08-12" version="1">MHFRLRIRNAEQLVQVCSQNEKAKRGADQDDVAVIENGALVVDDHGKFVAVGTTNEVDEWVRQQPQPVTFDSDFDATGLCVLPGLVDGHTHPVWSGSRVDEFAMKLAGATYMEVHAMGGGINSSVRSTRASSEEELYSLLKKRLDRMLKCGTTVVEAKSGYGLETDTEIKMLKVLETASKNHAIDIVATYLGGHSVPDGMTAAQATEDIVKKQIPALVQAKKDGLINPYFIDVFCEKGVFEYDDTKTILEAGKEAGLKINFHGDELHPMNSGKLCMCLQAHAASHLEMLDSANIQAMADASTFAVLLPTTMYILKLQSPPARELINQNVAVALGSDYNPNAHCLSMPLTMHMACCLMKMTMKEALVGATINAAASVDRADTHGSIEVGKCADLLVLDAPQWEHLIYEMADPPIQHVLKNGKFVVSHGQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XGP0</accession>
    <name>A0A6G0XGP0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_005027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000064">
        <property type="protein sequence ID" value="KAF0739461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XGP0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014371"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="177"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0739461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="382" mass="44262" checksum="BFD8EF8C5D95FAC0" modified="2020-08-12" version="1">MNNNDVEIMERRFSSHGGSKEYTMDELCTQLDDMDKELRQAATYGLLLVAKNEELVIAMESTRRRTCRAQRRDSNLGKASRNTTEKCHEFEDEIFQLQQLPTQSCTCSKEPRITPQVVADLDLLRRELEDKDFQLHNALKREKDKDEYIRRLQQTKRDTLDVIHQMKTSSAIEAKVRKSLEARNAVLAEKMAAAQTKLDLFQQAFLERELEENRLRTEIEELHEALRAQTHDVDTNANLIQTWMYKCNRLEKELESLQMAMPTRSSISSYEDIAATASFDRLESFFNLTALGIILEHQAQDQFKDGSSRQTIEAWFREALMAEMPYHTWHNWLTKRITATMPPIKGQPDRVSPTSALTKAITLFFDKYKHKVDPTAPTALLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XIH0</accession>
    <name>A0A6G0XIH0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Ae201684_004535</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="VJMJ01000056">
        <property type="protein sequence ID" value="KAF0739954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004241"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007812"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008990"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_008991"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13456">
        <property type="entry name" value="RVT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Peptidase A2" evidence="9">
        <location>
            <begin position="871"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="10">
        <location>
            <begin position="1549"/>
            <end position="1684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="265"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="335"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="349"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="380"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="392"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="408"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAF0739954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="2298" mass="263366" checksum="D23ED0CEF5FC88C2" modified="2020-08-12" version="1">MLKASATSLSSLFKNKKTPVLPSDKWNPLIPPLKHIGLRFIDHEKHKNEDSGGAVGWSERQREMLEQIAQLGDNDKPKHLEKELIELMLDDRNVWVSKFLQPEFTALPSVESRRPNQLERFTAHAYEKLTFYHLSRALKWLKLAFAMVNAKTRGIDEDELLLWWLHNYKNEADPQAYLEHNQSLLKTTELLYQMISCALYLYQPSDVTNREIPGIPGSGAFPGRMKADDRETIDNYTQVSLPDNPFERFDDDVLELFQSARGTSRHSDLMSFQTAQSHMPTDRSSSKKSQQSVDSYQAPKVDPSQTPATISLVTDLINAKFDDIRNMFEKLSPSITMPAEEMRAKESQRSQSLPSSRKGQTKRIEYPRDDETDTIADNNDGSHSDDSENSKHSRKPKNRGKSKKSESDDNSDEDDNEEFWNHLPETNSASVHVLSVDSLPIFSGRDESREVAYQWLKRFEQMARVSGWSEKERIAWFPSYLSPTIRSWYSQIGPGQQKTWKDVKRKFVKDWILNPLPKLDKYFTMIQEPKESLKSFFYRFNSAAQNAKVEYWKKPKILQEHILRFCSAIEGDRLAEKTYKSIEELEFHLDAQRKKQVLRQARHRHTDTSTPLKREKNRHRHIASLMAALAESDGDSKEHYRMNGECWRDKYCALCKRNGHPTEKCAKACQLCKPIHSKYDRCEGRERINAVKNFLEKLSIEGKINDLPKMDRLNCYTAPRANMENHKKALHMKLHIEEPTTSICISKSNENPLTPKNFEASVVSQVFPKHLGKIPLDPLADVIQDFLATVAAWKKQQEKRKNRREILNCNTSYDPPPLIPQICFTNSIDSLPGDFGLLEGEQLGFWKKSGVNDMPKSEQAFLKAFVFNQPTKILADTGANLSVIHRRLAESLKLNIDSSKKIGINGLGPNSISTFGMYVTLVMLILTSSLGWISCPKPDLLSTLLPGKSNYQMFSLDAAPTIDQSRFQPEIILQEGIDMTTEEMSSQLAMIPELSTDLPPFDITQLDIGELGISEEQKLQMVEVLADKAKYFIDSGNGLPPARGAACDIDVGNSKPIAERARRVRPEYMPKFFELLKGLMKFGLIEFSNSTWASPIVIVPKKGGQDIRLCIDYRGLNDLTELMLSPMPTLDSMLAGFDGLRWFLSLDNSSGFWVVSATKRARYVSAFICPLGTFNGREWLRDLPPGMETVDEDGEPRDMFKIGYLYEDKESLPIANRTSFADDIGDGAASWDEIIELTRRIVNRLTHFNISISARKSKFGKSFAEFLGHIISYHGIQANPRGLEQILKMPFPTRLRDMQSFTGSLNFYSRFIENYSIKAACLYELSEEDFRCGRISDIARATFDELKNSYASATIPKHSDHRLDAHLLIYVTDWAVSVTICQEHDNLLHPVRFCGRVLKIGEPRMAKWAKEIIALLRALKVCFYELSGRPLVVYTQYAAAKWLYHEKQDRSEYLAWAVQLSPWTIKFIQVKTMDGHWNMPSLMTNSLVQPFLEIQQEAQTSQDTNVPIYATLSIPLASYDDMTLEVYRPNRSKEIVNTDNIQIPTFSQNEEIFVATFDGAIKRTERIGSYGAVIWKLPNWDVLWAYHGIVENSTVNTAEYQGLLEVLTKAVSLKIPHIHIFGDSKIVIHQALKWIQCKQIHLQLLLRDVNRLRTFIKADLHHIPRHFNVSADHLASTALKNLITETVTDPLVLLHLQLKNKLPSYIQQKSHDESHDEIFSACFDVIRNITSHIARENPQATLTAQIDPPDKLVECLAPCKAAHYDRGGSSISIENRVCLERPGIPANIHLIGSKGVDHVEFDDPLFEFNRQIFVGMVNQNLDDLQRDRLRLISQAQDQEVELANIKAYLRDSIDNLTPQQCQRISKKAYEFELGEEGALYHVYWRNRRGPEPKMQWAIVAPRTMVDAIRFENHSSIEGGHFKLLKTYEKIRPNYYWSTMLADIKTFIENCAECNRAGAPPNRHMAAPSPGNISPEYPLNIIGLDFAIKLPKSDRGNSVLIVFIDFFTAYLMVKPAPDRSADTTAKTFEEKSFNKMLGQKQYPTLAYRPQSNGQTERIIQTLFRAIRIYSEDPTRKDWDDFAERLVFAVNTSISNTRHETPFYLMHGWDPQTTITSALPTTHTESARQNWRWRIRIQKQYLYAQGLARDVIAEAQLLRAEDHNAQLPENRGNRIAVGDDVWLFIHQVDAGVKKKLAHLWHGPFRVQRKISDYASEIQRVSRRGGRNYCFQVEVHDSRQKLRRNYEQRPTEMLEDVVAIRFDVDLALDDNAYDPLEFLEFAQMKQIQSVPLNLEIPNQIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XJZ9</accession>
    <name>A0A6G0XJZ9_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_004195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000052">
        <property type="protein sequence ID" value="KAF0740461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XJZ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010461"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028260">
        <property type="entry name" value="FAM177"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31206">
        <property type="entry name" value="LP10445P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31206:SF1">
        <property type="entry name" value="LP10445P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14774">
        <property type="entry name" value="FAM177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="72"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0740461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="120" mass="14209" checksum="6B066E73E47647E9" modified="2020-08-12" version="1">MSEDSEAPIEAAPYYWETSSTEDVGWSTKVWHWTHWTGDKIFTGMEFGGEVVATFLGLTRSKYDWILETKERDEHEKLLRQLEKRQRKQLRLQELLEEEKKKLNELEHGSNTEKPADILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XL64</accession>
    <name>A0A6G0XL64_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Ae201684_003831</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000042">
        <property type="protein sequence ID" value="KAF0740948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012571"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22709">
        <property type="entry name" value="FHA_KIF28P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022140">
        <property type="entry name" value="Kinesin-like_KIF1-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032405">
        <property type="entry name" value="Kinesin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12423">
        <property type="entry name" value="KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16183">
        <property type="entry name" value="Kinesin_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="12">
        <location>
            <begin position="1"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="348"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="637"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1125"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1260"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1059"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="362"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1133"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1154"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1184"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1282"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="68"/>
            <end position="75"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAF0740948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="1294" mass="143920" checksum="C8A2709B58691BA2" modified="2020-08-12" version="1">MVKETQQTIITDPDTGVDKSFTFDFSYDSFSPPGDPRHASQDTVWDDLGVKVLEHAWTGFNVSLFAYGQTGAGKSFSMVGYGNDKGIIPRASEVIFQRINGSSSGSDIVYKVEASMMEIYNEKVKDLFNPTSDNLKVRDHPSQGPYADGLTRSAVSSYDEITALMDAGIMARTTAATNMNATSSRAHTIFQIILTQSQLDPTTNKMMDKVSRINLIDLAGSERATSTGATGARLKEGAAINQSLSALGNCISALADNASGKKKTLVPYRNSKLTHLLKDSLGGNAKTIMIAALSPASVNFQETLGTLRYADRAKQIKNQAVVNEDPNQMLIRQLKEELEQLRRAMIESGGMDPASRPGSRMTSRDDPALANRPETRMLSREEAEERRQKEAEMAAIREQLEENQRLLRESEKSWTDKLKETEELAKKREEQLKAIGLLTNLHDIRAKAKTEPHLINLNEDQQMSEKLFYFFQPGENRIGRSDADRPQSIILGGLGILKEHCVVERTANEKLVLRGMASASIFVNGDFMKPDDQVHLKHNDRLILGNVNVLRVVVPSERREDSQDMSFDWQFAMKEMNCKQMDIKDDGMTDKEVAEMESRIKEMEERMREAQESANAKLEKQREEWEAHVRAMQDDMRAKETELKSQLEKTEQGGQVDKKKLAEQLAEQETKLAEEMAKAEVAYERKQSELIQKQRDLEASLQKQMKETKRLAEKKEREQVERAMLAQELLRTIPLVKEANSICEELKKPVTFSVKLLPKKPKLDQLGNPDADIADAIGTELKVLVTFQDAGTYRSVLWDIDKFDNEIYEMRDHYQMFLENNRNVAAIAIPEGGNDPFYEPPTPQLIGRAYLFLSTLHYGLKITDALPILDSKGVVCGKLACEITPTLLSNAVRPFLQEQQRSLMETPSGKEIVMPTLESFLDTNLRLSVSVPSLGGIPGKLCRDVFVAFKWHTDDANHVSSIAATTSVDPRLDFNVSIECAITKELIAYLRTTPVEFSVFGNVPSSSALTTLPHEVLSKEDNAAQSKSLSGDALREALAAAEAKLHMQEKVLVDNSAELEAHHAELDELRASLAKAQHERDDMIELVAKLQKTNRNLKDKLESCIVGVKTPTERYSIALQTDDELDPAVSKSTSKKHRSRKRSHREKLPSTKDAEDEDADGDDAASSTPVIAPAIPMLAKPESPESSTLPTLTPRSHSMAPVQQSKHEVGGNDASTSRTKTLPLPIASDLHVVEQRNDSVTIKSEKAKLYAPALSKVHVATSDVESSLPPIKRNDAPAIDVESPKSSRDKCVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XLC0</accession>
    <name>A0A6G0XLC0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">ER membrane protein complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_003717</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000041">
        <property type="protein sequence ID" value="KAF0741154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XLC0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009622"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008568">
        <property type="entry name" value="EMC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002809">
        <property type="entry name" value="EMC3/TMCO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116:SF5">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01956">
        <property type="entry name" value="EMC3_TMCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010045">
        <property type="entry name" value="DUF850_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01415">
        <property type="entry name" value="DUF106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR010045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0741154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="279" mass="31368" checksum="EDE4C546993FF7B1" modified="2020-08-12" version="1">MGEIILDPSIRDWVVLPMILLFVAMSVARNYVSVLLKTEEVGALDEVRKIQTLRRASQLRMNCHYIQPSAFAMRKFYFTSSEKRDGVQGVLREKVKNDTMNQMMNPTSMMKMMKGNMTFMVSNFVMMGLVGYFFGGFVLLKVPFSLSQRFKAMLQRGIDMATLDVSYVSSLSLYFLIMFGMSGFMSLILGRGNLNEDARAMQMQMGMGAGAGMGFDAPRMYKQERVSLRLHAHEFALEHAEKKLLGDPIPVKVEPVASAAPQSAADNSGRSKHQKRVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XLZ5</accession>
    <name>A0A6G0XLZ5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_003494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000037">
        <property type="protein sequence ID" value="KAF0741385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XLZ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010575"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0741385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="262" mass="29250" checksum="65D1AA20E76D42A1" modified="2020-08-12" version="1">MAFFPRLELSTKSTCYHGGREHENGYGYVDVDVIDRVLAEEEKKLSVFLEKMKYTSAPTPLGFKYRVEARREAEAQANTGGSSVNTTLDEEGEMMETQDDEMILDEDDELDEDEDMEMDDDMEAPTPSSDPRTPREEESRAGPIQTVNLTSFLASPIEAPLVRPPHRYSTGSYDPSSARRRYSLPRTSPLELPISYQNDESRRSSVMSTGSTLDLRHTPTRRFSFSSTATRSAGATPAGDGAQHSEASDTDNPLAWDYLGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XM88</accession>
    <name>A0A6G0XM88_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_003508</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000037">
        <property type="protein sequence ID" value="KAF0741403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XM88"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_010900"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="13"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0741403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="428" mass="47718" checksum="0B22DF0CC09095C5" modified="2020-08-12" version="1">MTSGKEVIHGVDIATLEGWLIKYKSKGKFFGTSNKRWFKVNVLQVDDAKDNPRLTLSYFKSKKATETRGWIYLEDVTDIHYKSDVMEIVSPSRTLRLKGETTAEHKMWYESLRQLCFPEPVAEKSEPVAHAKSPLMHNCETTVPAEAAPAPAKAAIKSPEAPARSEKKDERASSPSFQPSALENKPLPQPSKSDEKKGEPQPARIESKPSKDLSAEAKAPVKARAGSVLDDLKPRNDEENTLDFSESEDSDDDNEHDAGPSSSQRDGKTSRGIAKDPTTADNNYTDAEKQESTHESDFEHDEGKTLRDEDNSNNAPLEAKPSMALEEDDETKIEQFEQSPRPQTRDKRDNPYFDDEDNDEEPPKESQAPPPKAADMSSVRADNNFVTEDWDEEEPAPVSKKASPSKEKRGPRTGGVQADANFVTEDWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XMU0</accession>
    <name>A0A6G0XMU0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cullin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_003372</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000036">
        <property type="protein sequence ID" value="KAF0741705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XMU0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020873"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cullin N-terminal" evidence="2">
        <location>
            <begin position="37"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0741705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="272" mass="30901" checksum="02CE1A2644FD20BF" modified="2020-08-12" version="1">MESKQVVGLEEGWEQIKTKGIDVLVAIIENGNAEDTAHQITPHQLMPIYEVCYDMCAQKAPYNWSAQLYARHGETIEIYLREKALPALQNQHGESLLNELQRRWQNHNFMIKWMSKFFMILNRYYVKHNSLPSLANAGLNAFKTVVFSVIKKDFADAILASVDKERGGEIVDTTLLRNCTEVFVAMGMGSLEAYESDLEGPFIKRAVSSYNSTEMQAWMDGGSTSPEYISKVDEILKIEASRVACYMHATTEAKLLRALRMELIVNHQTVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XNE1</accession>
    <name>A0A6G0XNE1_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_003101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000034">
        <property type="protein sequence ID" value="KAF0741915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XNE1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018597"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052651">
        <property type="term" value="P:monoacylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006660">
        <property type="term" value="P:phosphatidylserine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF194">
        <property type="entry name" value="FI04476P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="108"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0741915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="230" mass="25038" checksum="C3ACD8207BB114EF" modified="2020-08-12" version="1">MSVLCLWSPLLHPDAVRNPSESNAMPSITAIASVLVSAVGTFLTSPGQGVLVYLNMVSISPWFDFSKPAEPQLGFNGLPRTTNLYLSSTDSVTIGVWHTRASQRADKVVLYLHGNGENRAIHVGVLKHTLYSNSPFHADVVSPDYRGFGDSSFVQPTEQGLYDDAMTAYKYIVSTLGFQPHQVLVHGYSLGSAVATRLVHTLCTLHRSCPAALLLEVRQPFDLSNSLTHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XP62</accession>
    <name>A0A6G0XP62_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">MoaB/Mog domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ae201684_002842</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>adenylyl-molybdopterin + molybdate = Mo-molybdopterin + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>molybdopterin + ATP + H(+) = adenylyl-molybdopterin + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:31331"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58698"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the MoeA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the MoeA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the MoaB/Mog family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000030">
        <property type="protein sequence ID" value="KAF0742175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XP62"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002164"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061598">
        <property type="term" value="F:molybdopterin adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00886">
        <property type="entry name" value="MogA_MoaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.190.11:FF:000001">
        <property type="entry name" value="Molybdopterin molybdenumtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.980.10:FF:000001">
        <property type="entry name" value="Molybdopterin molybdenumtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.980.10:FF:000002">
        <property type="entry name" value="Molybdopterin molybdenumtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="entry name" value="MoeA, C-terminal, domain IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.10">
        <property type="entry name" value="Molybdopterin biosynthesis moea protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.190.11">
        <property type="entry name" value="Molybdopterin biosynthesis moea protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008284">
        <property type="entry name" value="MoCF_biosynth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
        <property type="entry name" value="MoeA_C_domain_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF045515">
        <property type="entry name" value="Glp_gephyrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192:SF5">
        <property type="entry name" value="GEPHYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="MOLYBDOPTERIN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03454">
        <property type="entry name" value="MoeA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="MoeA C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="MoeA N-terminal region -like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="Molybdenum cofactor biosynthesis proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01079">
        <property type="entry name" value="MOCF_BIOSYNTHESIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="11 13" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoaB/Mog" evidence="14">
        <location>
            <begin position="196"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="MoaB/Mog" evidence="14">
        <location>
            <begin position="457"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF0742175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="623" mass="66470" checksum="D2CA55AA0DD01AD3" modified="2020-08-12" version="1">MSCNCSDGVGSLRNSPYDMIPMQEAINTVLREAQPLLKTTVSLQEALGCVLAETVKAKEPLPPFRASVMDGYAVVASDGVGEFPLLSRVAAGDAPGLSTKPGYLSYVTTGSPVPDGADAVVKIEDTEAVLNEAGQEVAIKILHAVTPGTSIRPIGYDIQQDEIVVEAGEAITPAVLGLLATVGESSVSVFRKPVVGVLSTGSELVDASHSIHDGKIRDSNRPMLLSYLQQLHVRTVDLGICSDKWDSLRSLLLSKLPSIDVLITSGGVSMGEHDLVKPLLKELGKIHFGRIHMKPGKPTTFATVQVENIPKLVFALPGNPVSCLVTACLLVQPALKRLSGHDVATSAPVTFRARLQHDLPLDKERPEYHRAVVNWSAQNEWVATSTGVQASSRLLSCRHANALLYLPVGTRIQAGALVDCIFLTETGLLSTPTSIPSIPPPKAASSSAKKALKVRACVLTVSDRVSRGEAEDRSGPTMQKKLQDIPRLDVEIVQAAVVPDEREEIQDIVKTWSDDKRVDIIVTSGGTGFSPRDITPEAIKPLLHREAPGLVHKMMAASLEVTPMAILARPIAGTRNQTLVITLPGKPNAVVETIDALASVLPHALHLLQDVSHGHHQGKVDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XPA7</accession>
    <name>A0A6G0XPA7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_002670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000029">
        <property type="protein sequence ID" value="KAF0742266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XPA7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009394"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053218">
        <property type="entry name" value="Pathogen-related_defense"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31723:SF10">
        <property type="entry name" value="PATHOGEN-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31723">
        <property type="entry name" value="PATHOGENESIS-RELATED FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="40"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0742266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="493" mass="56514" checksum="A1718038A9153577" modified="2020-08-12" version="1">MMDRRSSAQSQLSSMRSSDIFPGSTDETLDAASHIALASTVAMSSWLRFKGGFFKGWTMYYFVLSRTNQLTAYVTDDYQGKPWKFRVQAMMVQTTRSIHLGFIVTTLKDGVLTLAAANSADYKQWIEVLSEKQPIQTPLTRYSLTARDRDFEREESDRLTTIERSQSLDLNDKMQKEVFLYVPTTVIPLHGDRIAQAKEEIVVLQSHMGQIVPHRGNLEDTNIQWRIGRPEYALLDLAFLQGKTHNHAPPSLEWTVQNLIKKWEMEVSHKANINQWTTMNPETFKLQVNMGPSTSVHDLQQSGKYNAMLSHCPRHIYDAMGSSRERSYLSFSSVFPDGFAWEVLEVFTPLPRVSFSWRHWGYCSSKKKSENSEEGELIELKGFAIIDLDVSMRLNGMEFFFKVEPFLEALRKYNFSELPPMPTRGRRMSAPATAMDIPSSRSRRFSRSQRSMSTSLDESVLGVEEFLRCPHITTVPESQANMKDNQHRHTMAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XQ76</accession>
    <name>A0A6G0XQ76_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_002503</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000026">
        <property type="protein sequence ID" value="KAF0742603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XQ76"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_002897"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000010">
        <property type="entry name" value="Transcriptional activator Myb isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050560">
        <property type="entry name" value="MYB_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614">
        <property type="entry name" value="MYB PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614:SF232">
        <property type="entry name" value="TRANSCRIPTION FACTOR MYB3R-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="HTH myb-type" evidence="5">
        <location>
            <begin position="17"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="3">
        <location>
            <begin position="18"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="5">
        <location>
            <begin position="63"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="3">
        <location>
            <begin position="63"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="4">
        <location>
            <begin position="66"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0742603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="239" mass="27434" checksum="D21A44A73F947C49" modified="2020-08-12" version="1">MPSSDDKESTTERKCVQKWTPEEDALMLELVQTHGTRRWSLIGSMLQGRNGKQCRERWHNQLDPNIRKDPWTPEEEMLLKVAHNKYGNKWAEIAKLLPGRTDNAIKNHWNSYKRRGHRAMQRKSRAMAFVRDETDDSLHAKSMPTLAMLNRQLDASKPTLPDIKQFAIHDPSSRLADTAYNTYARPSVHRTTLQYHMTLPLPHIHSLSAVQATSNKENTEHDPQLTVLADAASVQTIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XQ93</accession>
    <name>A0A6G0XQ93_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_002551</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000027">
        <property type="protein sequence ID" value="KAF0742452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XQ93"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009357"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0742452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="212" mass="23002" checksum="23D184A0509CD0B7" modified="2020-08-12" version="1">MADFPASPPFNNVLLANDDQLNTPAVPAGGVDEAAIGREALRAFKASALRLVSMESISEAELGMATYRVAEAIAQFQGGELMMPLVAQALAAGLAPLQQEIQALHQGQIALLQRQEEMLEEIRAARTDYRILLVNSRIFARNQDAHVGTTTPFAPPAKFNPGFLIHMPHAAMVNIADVPADVALRLKEGLLCQDRTCFLLQFCHFHITAGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XQR2</accession>
    <name>A0A6G0XQR2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WRKY transcription factor 19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_002456</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000025">
        <property type="protein sequence ID" value="KAF0742757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XQR2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_019851"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827:SF1">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0742757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="172" mass="19620" checksum="117E93F12ED1F804" modified="2020-08-12" version="1">MQKCFFKSCSNPVTSDTWRCDFHRGRDRCTVENCFSQAYARGLCARHGGKRMCQSPGCPHRVRVANFCSKHGVKKAKNRCLEPGCDLPAQSHQLCVRHGGSRRCKWTNCTAYARKGGFCARHTTQQMKEESKRLEETVQALWPADEPMANVDFELPNEDPMYTDILNILLTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XQZ4</accession>
    <name>A0A6G0XQZ4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Acid phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_002264</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000023">
        <property type="protein sequence ID" value="KAF0742868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XQZ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012757"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF110">
        <property type="entry name" value="2-PHOSPHOXYLOSE PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00778">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026153121" description="Acid phosphatase" evidence="4">
        <location>
            <begin position="19"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAF0742868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="448" mass="50129" checksum="34B3AF8828D36BBE" modified="2020-08-12" version="1">MRCLGLLAVAALLHEGAGSTYPAYCAKDMNLNAIQPLKDPSPVELVQVQIVVRHGARTPCFADVCWKDYDEEWNCNEREITRPQLGNDVPSVEFTKVFTAGSNIRRGNCSLGQLIDEGYDQEIANAKHFRDAYVGRKSGLFGASEAIDLTNSSDIYLESSDIPRTLQSGQTIISALFPNLVNSKRPVPWRTQDVAVSSIFPNERICPSLAALGKEWTTSQELRTLQTNPASLELDLALDEQLVTYSSQSLYDCLMTSRCTDRDMPLSDELFHLVTNREENLAIQQYLFRDSRYAKIGMKSFLQALVARMQPNQPRLALYSAHDSSLMAILAALGGKAWLTEWVPYASHIVFEVYRTKTSRHVVRVLYQGQPLFLGSCTSELCPVEELISIVDAMPSCLLEDPTNEFAKVKHMPMMLMLVTGIVVGGAVGFIVARRYFSARKQQYHRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XRM3</accession>
    <name>A0A6G0XRM3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_002147</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000022">
        <property type="protein sequence ID" value="KAF0743089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009987"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="4"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
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        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041969">
        <property type="entry name" value="VP13D_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009291">
        <property type="entry name" value="Vps62"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF408">
        <property type="entry name" value="OS09G0560450 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
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    </dbReference>
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        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Vps62"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
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        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="RCC1" evidence="4">
        <location>
            <begin position="301"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="4">
        <location>
            <begin position="353"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="4">
        <location>
            <begin position="408"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="4">
        <location>
            <begin position="461"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="4">
        <location>
            <begin position="513"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="4">
        <location>
            <begin position="564"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="4">
        <location>
            <begin position="614"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="8">
        <location>
            <begin position="639"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="8">
        <location>
            <begin position="2276"/>
            <end position="2473"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="4">
        <location>
            <begin position="3014"/>
            <end position="3068"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="4">
        <location>
            <begin position="3069"/>
            <end position="3122"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="4">
        <location>
            <begin position="3123"/>
            <end position="3174"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="4">
        <location>
            <begin position="3175"/>
            <end position="3227"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="4">
        <location>
            <begin position="3228"/>
            <end position="3279"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="4">
        <location>
            <begin position="3280"/>
            <end position="3335"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="6">
        <location>
            <begin position="4076"/>
            <end position="4137"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="8">
        <location>
            <begin position="5124"/>
            <end position="5330"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="8">
        <location>
            <begin position="5458"/>
            <end position="5645"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="7">
        <location>
            <begin position="5698"/>
            <end position="5729"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="9">
        <location>
            <begin position="5991"/>
            <end position="6344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="4491"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="4491"/>
            <end position="4528"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="6307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="6360" mass="695184" checksum="4D87DE947D1E136A" modified="2020-08-12" version="1">[encoded data, 6360 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XRU6</accession>
    <name>A0A6G0XRU6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine aminopeptidase S33 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_002152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000022">
        <property type="protein sequence ID" value="KAF0743095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009982"/>
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    </dbReference>
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        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="AB_hydrolase_fold"/>
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        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0743095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="119" mass="13483" checksum="DAD0044DC7D223AA" modified="2020-08-12" version="1">MSFWASLFCTRALDFDTYAGYLKANLKEEGRLRALTKLFRASKANAHKHLQEYKLPILIGIGSIDPNFSSPEAEAQYIHDTIGTTTEKQVMLYPSVKHYPHTECPDAVAADLVHFLRQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XTC0</accession>
    <name>A0A6G0XTC0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_001747</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000013">
        <property type="protein sequence ID" value="KAF0743604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XTC0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014156"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13999">
        <property type="entry name" value="STKc_MAP3K-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF214">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="99"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0743604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="368" mass="40108" checksum="5ECFB1ED23DC1E11" modified="2020-08-12" version="1">MGDGGIYGGVAAGVVVILIAVYFIHRSWKKGKSSSNDGYVNQTTLHTARNPLTPGANKSKRNMNVPESVRGGGEIHTIVDPSIGFFPELVPYRIQANEVQLVRAISRGAYGVVWLGQFHGQPVAVKRMIEGDDQAVLFSKEIQTMARLKSPNIVEFIGATWTSASDLSAVNEFMDGGDVRTALENKSIKLSWSNEKINWALDIARALAYLHGLTPKLIHRDLKSKNVLLAAKNVAKLSDFGLSRNRSYEETLTAGVGTVRWTAPEVMLGDIYSEISDVYSFGVVLSELDTREIPFDDQKSSKGGGDIDMAIVVQVAKGELRPSFLPTCPPSILHVAKACLQFDPALRPSSARVVELLEQAKADLQQTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XVL4</accession>
    <name>A0A6G0XVL4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Ae201684_001170</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XVL4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011300"/>
    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF3">
        <property type="entry name" value="FERROPTOSIS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="5">
        <location>
            <begin position="6"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAF0744713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="388" mass="41378" checksum="6E2A417DDA87C067" modified="2020-08-12" version="1">MSSPKQIVVIGGGYVGIQFAQKLAKQLPASLASITVIEKNEYTFHAIGIPRAYVDPSYVKKLFIPLNQALAASHTKLIRGLADTINDKEVLVRKIVDNQPEEAVTTIPYDYLIIATGSSYTSPVKVSKTTFSVKNAEDAIVNTANGIKAASSVLIIGGGPVGIEVAGEIASAYPDKSVTILEVNDTLVSNAGVSEKFRTNLTKKLTALKVKIVLGEKLPERITANGFDKKTLTTDKGTVLESDAQLVCAGMQPNSDLVRKLDPSLVNERGAVKVKADLHLDDKRFPNVFAIGDVNDHPTPKLAYTGDIQGAHLAKQLAAVIKKGKGAIDPFAMKGPDGLFLPLGPKGGIAQLPVFGGVVAGDTFVRSMKSKDYFAGKMWSTWHAKLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XVP8</accession>
    <name>A0A6G0XVP8_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
            <shortName evidence="8">dUTPase</shortName>
            <ecNumber evidence="8">3.6.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">dUTP pyrophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_001063</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>dUTP + H2O = dUMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the dUTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="8"/>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XVP8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009473"/>
    <dbReference type="OrthoDB" id="10261072at2759"/>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.40.10:FF:000004">
        <property type="entry name" value="Deoxyuridine triphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00576">
        <property type="entry name" value="dut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001862">
        <property type="entry name" value="PRK00601.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241:SF0">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="dUTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase-like" evidence="9">
        <location>
            <begin position="14"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0744596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="230" mass="24836" checksum="47266D5B999E5999" modified="2020-08-12" version="1">MGREVLLVKKLTAHAILPTRGSNFAAGFDLSSAYECVIPAHGKALVKTDLAIAIPSGTYARVAPRSGLAWKSHLDVGAGVIDEDYRGNVGVVMFNHGSEDFHVRPGDRIAQLILERIVSNAPVEEVEELTETDRGDGGFGSTGVAKKFKVDDQIESSEGTSSGAHVDTSSVVQAIRAIESDLDEAQRKKLKNIVVQANERKFDLLHKASAQFLASGNKESYLEWVHALLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XW46</accession>
    <name>A0A6G0XW46_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_001219</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000009">
        <property type="protein sequence ID" value="KAF0744764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XW46"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021772"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="281"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="422"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="435"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0744764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="501" mass="56657" checksum="C6FEA9F2E784EA01" modified="2020-08-12" version="1">MQVNNMNFPRVEFTQEVYEKHLAHMERLSDLALNGRSGWDKATATPAHGWVSMTQKMGWEILSLEKHLAAGVHEYLCLGSMNTTIEALQDAFYVHNTYEFRALCAVLYDDAIVDAGVLNVTHQRTQDDMGQFFGVKYMKLMVHVMNDEDQEQEYIYLEFAGTRRDALGRKTFFVISDPVAIKPGKHSLSSGQRCSCVKLYREAPDGSVEVTVRTKLVPGISSKEPASTPRTVLKNKQHLVFWKSMGVFIPSGLSKDLLCINREAYAPEARRLTTGPFSHSWQHGSKCSVCMKGFGLLRRKHHCRRCGSTVCATCTMSLYCVDRPTKLRTSQPLAVEKFCKSCLAHARFEAMRATRQPPMSIAGDAGMDWEVAHLLSPSRNGKGEYFFMNERFSSSHSSIRVISPRQQPISYPSELSSFSGRNVAAYSGNSDDSEPERVGGHREKNGSGVGSVHRNHVQQYSVQQIQGQQNPVDILEQQLRMFRFRSDEEQFSSQRQPQQRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XX75</accession>
    <name>A0A6G0XX75_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Translation factor GUF1 homolog, mitochondrial</fullName>
            <ecNumber evidence="8">3.6.5.n1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Elongation factor 4 homolog</fullName>
            <shortName evidence="8">EF-4</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">GTPase GUF1 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Ribosomal back-translocase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_000611</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the GTP-binding elongation factor family. LepA subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.n1" evidence="8"/>
    <dbReference type="EMBL" id="VJMJ01000003">
        <property type="protein sequence ID" value="KAF0745033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XX75"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001734"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097177">
        <property type="term" value="F:mitochondrial ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03699">
        <property type="entry name" value="EF4_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16260">
        <property type="entry name" value="EF4_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01890">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000078">
        <property type="entry name" value="Elongation factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000015">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000007">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2570:FF:000001">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000004">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="entry name" value="Elongation factor 4, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512:SF7">
        <property type="entry name" value="TRANSLATION FACTOR GUF1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="TRANSLATION FACTOR GUF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="44"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="53"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="121"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="175"/>
            <end position="178"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0745033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="642" mass="71076" checksum="670184653F34900F" modified="2020-08-12" version="1">MLGWVNRRAFLRGAIRRHFSSHEEVTPKTLGKIMAAHMEELRVENTRNFSIVAHIDHGKSTLADRLLELSGNITSKERESAQHLDNLKVERERGITVKAQTASMLYDDKETNKRYLLNLVDTPGHVDFSYEVSRSLSACEGVLLLVDASQGIQSQTLATYQAAKDKGLKIVPVLTKIDMPHAQPEDCMLTLSTLLDVDPESVLLTSAKSGIGIEDVLQTVVDMLPPPVADRVAPLKCLLVDSYYDDYRGIVCLVKVVDGKISPGDKIISAATKSSYDVQETGVLLPHRSPTPALYGGQVGYIIAGMKTTTEAKIGDTFFHPSKPVEPLPGFQEARSMVFASMYPTDDCNFDDLRTAMGKLTLNDASVTAQIENSGALGMGYRCGFLGLLHMEVFHQRLSDEQNMQVLVTAPMVPYTIIDSKGNRTVVETPADFPDSTKYYQVEEPMVEASILTPSDYLGAILVLTKEKRGEQTNMVYLDDNRVALTFRLPWQEVVTDFYNELKTITSGYASLNYREIEPQQADIVKVDILINGKVLDALSFVCHRSKATAAGRALCLKLKSVIDRQQYEISIQATLGAKVFAKERIAPFRKDVLIKSGKAVGGGDITRKQKLLKKQKEGKKRMKTVGNVQLSQSAFWSVMSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XXM0</accession>
    <name>A0A6G0XXM0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LarA-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Ae201684_000279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000002">
        <property type="protein sequence ID" value="KAF0745248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XXM0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_018124"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050043">
        <property type="term" value="F:lactate racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048068">
        <property type="entry name" value="LarA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043166">
        <property type="entry name" value="LarA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018657">
        <property type="entry name" value="LarA-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33171">
        <property type="entry name" value="LAR_N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33171:SF17">
        <property type="entry name" value="LARA-LIKE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09861">
        <property type="entry name" value="Lar_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LarA-like N-terminal" evidence="1">
        <location>
            <begin position="33"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAF0745248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="474" mass="52564" checksum="2A4FE1DD9FF87656" modified="2020-08-12" version="1">MVLYYSEGSPTAEISDEGLKQALIQAMDKINGKEKRKVMLVPPDFTRFHSKSGIVTQHAYEYFGQHVKDIMPALGTHAPMTSDEISKMFGSVPQNLFRVHDWRNDVVKIGEVPRELVREASDGQVDEPWPAQLNKLIWDGGHDLILSIGQVVPHEVMGMANYNKNLFVGTGGSDAINFSHFIGAVYGMERMMGRANNPLRRILNYASDHFLTHLPIVYVQTVIGRRDDGSVVTRGVFIGNDDECFTKAAALSLQVNFTLLPAPLDEVVVYLDPEEFKTTWLGNKSIYRTRMAIADGGKLVVLAPGVTHFGEDKQIDALIRKYGYRTTPEVLAHISANRDLMKNLSAAAHLIHGSPENRFRVIYACGQNGLTKEEVEGVGFEYAKLEDMLDLYKIDGRKDGWNTIESTGRPFYYISNPAMGLWAYEGRFEASSKPEAKPASQPTQVLTELHGDEVCVDAGVGGGPFTKADHAALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XY59</accession>
    <name>A0A6G0XY59_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Glycosyltransferase 2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_000130</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000001">
        <property type="protein sequence ID" value="KAF0745679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XY59"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011370"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016760">
        <property type="term" value="F:cellulose synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030244">
        <property type="term" value="P:cellulose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005150">
        <property type="entry name" value="Cellulose_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050321">
        <property type="entry name" value="Glycosyltr_2/OpgH_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43867">
        <property type="entry name" value="CELLULOSE SYNTHASE CATALYTIC SUBUNIT A [UDP-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43867:SF8">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03552">
        <property type="entry name" value="Cellulose_synt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="481"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="896"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="929"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1007"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1033"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1071"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0745679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1114" mass="122965" checksum="5B5B60D5FEB6933F" modified="2020-08-12" version="1">MVTLGAAVAGSVGVCGGFALALGGWSGMSLGAKSLFISVQLLACFGMSFVASYMIMDNLASVSDVLRIAVSAGVGAGVALLIIFATSLGPYLLILLSGAIIAPWFLVLDRYTGQVFVGQPGFAKQEFLIAFVIIYFLVFVTSSKNAELENHRFKYLLMSAILGGWLFSDGILRLAFPTNVPLANLLFGIIGISQKPDLPDLSGDNLMIMLVIWGGVALVGMINQLAMRWGLFCYNKVGGHLPLENVLQEDLPELPVGAASASAAVPARIVCENCFATVPPATAFCTECGEAISADSKGDPNVSISSAQPPAVAAGADGKTPQRWQEMPNRAFMTTTSFVDPKKMTEKNDAARSIRFLDQGDGTGKNPYESSFRSFAMSTFSIAGRAAEPVATPNIRKYKMSGGGFFHIFYFLSAITGIVWLVFLITFYPRESPCNNTQPHLGCSLIEDSIKTANKCYPSTVAQNVDLATNEPYCIKPTPGGVWFCYIIFVGSEYLNFFLGLLFNFSMWRPIRRGARYLNDFKPPLPKEQWPTVDIFLCHYSEPVVDTMKTLKNCLAMQYPPELLRIWLCDDGYTKSTWDANNHFKVTVNTKNIQFCGDLRGDVARLMHERVVGPHSSVREIKGGGTRGIQRRDCAVGSLSDDYDYRDRGLPRVTFVGRMKPETHHAKAGNINNILFNEGADGKYILILDNDMKPHPKFLLAVLPFFFSEGEAVDGGGRQYSDDISWNQVAYVQTPQYFEDTPQLTEMGDPCGHKNTIFFDAVQCGRDGFDSAAFAGTNAVFRRQAFDSIGGIQYGTQTEDAFTGNILHTAGWDSVYFRKDFEGDAKDRIRLCEGAIPETVAASLGQRKRWAMGAVQILLMKGESEVDPDWRPPRVPAPDPKPSLTFPRKMFFYDSVLYPFGSIPALCYVFIAIYYLNTGDAPIYTQGNLLLYTFIPVMMCRWMLNLLANRSVDANDVWRAQQTWFSYSFITALAIGEAVRWRLTGVISAWANTGAGQKTSWTEIPNVLMYFTLVVSEFVALVRFFQYENATSPWNYVSAMFFGFWIMSNLYPMVKMSISTYAGWDHTSATFTANVFGSLLLIGIVVFVQYWQMYFEVNLLHASGGVAAGTTTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XY69</accession>
    <name>A0A6G0XY69_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Calmodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_000140</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000001">
        <property type="protein sequence ID" value="KAF0745689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_001379"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051295">
        <property type="term" value="P:establishment of meiotic spindle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007051">
        <property type="term" value="P:spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051185">
        <property type="entry name" value="ASPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22706">
        <property type="entry name" value="ASSEMBLY FACTOR FOR SPINDLE MICROTUBULES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22706:SF1">
        <property type="entry name" value="ASSEMBLY FACTOR FOR SPINDLE MICROTUBULES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="427"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0745689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2043" mass="230053" checksum="D24FEE0586A03D2F" modified="2020-08-12" version="1">MPRSPPHRPKSNKNDQTTLPRGWNDNVTESRIPQYDGLKDKHGGLAPKISPPKYTSSTKKTRPTTTSPTQEQQRASAKRQDSHGSIVKAPAHRGNITYEADMPGNGGMELDVLKAIILREDYISRLAELSRSESPYAVVGSMANTLDLIRLTTVEVVEAIATWRKRQTKHMPFKWNGINYLVKIPSDLDFLEECDVMRRWLGFSMTRNPFVMPENLDARSVVFEPGRPTSPSVDSDPFMAIGGIPVAPAVSTPSASTRSPPRQKTAYETRIINDDELVPRPKPVAAQTTIQGQPKPKTTFVLPSQIGDLDVLRIREAEKLLLEEEALCGRYKRDLDGRVVPEAVANQQAKTASIRHHHVATAPPSAIEPNQPPVIPVVRSSSANDAIIPSKGNEKLTGNIKQAGMLAPPTKLSMQGRLRMPMHRSRGAKMEEDLEKSIIANKQLEERIAALRDAISKAEVPSTEASDSPRAIDSDAALEKLKCDLASQVDQFERKKREIFRKQEAMEAFKNAQMTAVENARMAELLRRKQMDEAQILAEKTKLVQIHMATKIQKIVRGVIARREYKTIRIRYTIASTYIEAVVRGFLARRRVYKLFARRKAAIQIQRMVRGLLARNATRLERLAQKQRRASVVIQKMYRGRLGRKRMKNYRALISAKLKFIYLTEHLSSEELAEMGRLLCAYAKHPESKYTIKPSHVVLGLVRILKSSCESCLCNEDQQRLSLPIHEVRWMEGGQYLRRARALLRTLHTIATSAGRLLLPLSAETLALMRAYKHDCEFTLEHFSMQGVIAKTTSTLFQMIQALNTISEAQHIFLPPKPFLAVSLAEYADDDRAESNKCDLEDHHSDRQFVPLALIQDCPSRPRPLLIVLSRDVPGYAKELLVNNMMTTFPGLFLRINTPSSIHIDTIQQTFNAGYSVLFDADIGLSIGQQRKFLGQFSIVSKALRPTPLSIMIQGSLGNRVGPQGTLGVSDLDLRLLFDGEAKRHAQLAANGLLALTDGSMFDEMIRTSQEDCPHIGLVLVMEAILILLTPTQRYTSPESATSAVTWRLSRRLLAAPQLFADKLLALDLRQIPADNTMVLKEYIEHGEWPVVNTSHGSLMYRLALYTHAIISFAIHTHRHGGCAMPISRSKPLPGLFSSVITVTDPTSYDPQYKVITAKLACAILEDVRVYRESKKINDRYHIITLYRDCHRVYVSCYDPLTSNLWKADIPETDMNALLAPNSIEVLQNKKPPKNPKELYKQIVGYCALSKPKGKDPTVQLELRPRARRLCRHARKIHGHFATITVSEMSLGHLRLDVHVHDTYSAWTSSWAVHVNDDELQYLKMNATDPIEWKAYDEMDVEIMHRYVLDRLQVEHSCLTLPFIHRQTAKPPHTTEAPAAMRVRVRKHGGSGRFLLRQVVVSPLTKVTWVVSVFEITWTRALRLEAYRPDTSEAMKLNITYREREELLLSSFKRQKKRPRPAAISSPLWLQCILNRVTIANDAIKLDTELDSGVFQLCYFPDIYSSTEPKVNRSVRIIFRVVLVHLTNDEDVGLHLFIYLPRISATHLLVLSDSEVQSIVDIPWPCTLFETRQRAIRALLPCCVYDTNEKLVRLENAACFVKYSTLVSPVIQVAPASPQAPQEDEPPPEVRPLTPADLDLLHNTVLLLDGVDKLVLLYDIAKQLHSGSYKCNGTLLVVTATMTAYLKHIVEPNKPGLPDIHRSIDCFDLALEIYHPEISRHCVVHIDGMQDLREVTGPDQAHLIGSNTFHEWLHHIMTNRLDRSISDDGTFTVSLVRSRLYSQYKATPVNTVMEENAVQNDHLLIDQRHKRGVKLLSKAKHIRGHAVIFTVFDLTEAPEDAARRALHVHLRLDGYIAATSQKLSIWVRDAVLVEAVGSHVELLEAGNEQALAQHLIDLMDLEMAVDNTTVERLFVKEIVVAPSAISSENDSPRHRTTPRTSPPCLFKTFRTVGGEKVLMSIRDTSAATPDLPLRIDFYQPSSSLSTFLDVPKPLLKTLVATEPSMWTDKAQVQAALQTLLSFVSVSRVESECGTLLQVEWKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XYK4</accession>
    <name>A0A6G0XYK4_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_000060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000001">
        <property type="protein sequence ID" value="KAF0745606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XYK4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011489"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="85"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="336"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="428"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="371"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0745606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="450" mass="51087" checksum="60AF1C908C3D4F4C" modified="2020-08-12" version="1">MGKRVPLPTTTATPGLLPSILPKPDYWQLTHVEQLLREKILERTKIQDGKFIYQQAYRLLERHRGRGIDLPSFTHAIKTTLSVDLGDADIATLFHKYDVDGNGRIELYEFINRVLPQDYDTKVPSWIQTSIDRGDAQQLAIRQADRRTYENGRAFGEAYNPRRSLDDLRHDILVKLHQKIPKCIDRLRTAFKLLHTTGAPSMSKIDVRQSIRDVLGIALTEPQTNGLLDAFVIDGTDRVDVHAFLQRIFEADEVAPKEAGIFAADSEDDMRFHGGKRQIVPDRGIVQPQRFQKRVHGYWKTKHKNANPLRLQKPPPPRRRFTSKFQVPAVASAIPRRAATAAMDPPNAPSRKPRRLVWAKPLQLEDEMQRPMPPPSQHRPTPPKTTSKESAARPATHAVATTLASMSLEDDNAAYNGPRVAVSHRLQHSEAPYKANKPNWRVTENTFTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0XYX0</accession>
    <name>A0A6G0XYX0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_000144</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000001">
        <property type="protein sequence ID" value="KAF0745693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0XYX0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007200"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0745693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="349" mass="36971" checksum="504598E3185358A5" modified="2020-08-12" version="1">MAVDVCTDSSQTCDVNAACALDSNQLPTGMKTFCTDSSTVSPCRDCTAQGQNCYNAGECQDSLFLCDYLTDAQKAALPSSHPCLNVACQLNKNSPQCSSQVYQFCCAPGTANCTNTGSTTCTPSGCSSFMTAQAGTVDYSRTACPFANASYTCSNPECNNTFIYQDIVNTFAANQGCSGSQCITDFLPTVCQNGPNVTSTSTADKLACTNRIVDYCTNNSTDPGCTQVCPYSCNAQPNCPCRSADCAAVYQAPICVMKSGACANFKAAFKTEMFRQRFFQPKSSNLAYAKNNFGPPSGPFTWTDALNTSKAACNAVVAGLGDKIAACVQTSFSFCNANPWQAVRHIMNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W4Q0</accession>
    <name>A0A6G0W4Q0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_018982</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000370">
        <property type="protein sequence ID" value="KAF0721702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W4Q0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017888"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0721702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="386" mass="44488" checksum="87D5BAE199D25206" modified="2020-08-12" version="1">MEIPDHLGTHRHTASHSNNWLDPMSHAARRREAARKGMAALRAARKREIKTLMAQKQRLESALEYLKAHPEEQHQGIMPFAYARSVLSKRKNAFMKAQISTHKRWFQWFRGRTIPKQLHEGYTETRLPKDASSRQSGFEWLSMKAYNMSLVANQQFASKENNVADDIQVKLHLGQDDNGICIRAIECHLQFTVDANFENVAKTWWFDLVESTPLVSSSIMERLGDHIVYVKHEHTTWMYKRLCVAGVFLDTKNDRITITQTGIALDDRFPFMEDESRTNGIVFQHVTDHLTIVRWSILNFCPVNRKGPLSLREMARNMRCSVSSKDSEETLLAKIHSASENVLEDLHNQFLRRCSRFKLEPPTLGSRDLSIDALCPTNLGHVNIPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W5B7</accession>
    <name>A0A6G0W5B7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RxLR effector protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_018805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000356">
        <property type="protein sequence ID" value="KAF0721946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W5B7"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026174255" description="RxLR effector protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0721946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="92" mass="9615" checksum="F215CC5630B7507D" modified="2020-08-12" version="1">MRLVVVVSMALAALTALTAEAKMDKNGESGPKVLYEAPPSQRSPSFGHAPSMKSRRGGFRGAVSKGFSKVGRCAVGCFGSYSPASNRHKNTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W6V0</accession>
    <name>A0A6G0W6V0_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WRKY19-like zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_018908</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000364">
        <property type="protein sequence ID" value="KAF0721802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W6V0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016275"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056866">
        <property type="entry name" value="Znf_WRKY19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827:SF1">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24906">
        <property type="entry name" value="Zf_WRKY19"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WRKY19-like zinc finger" evidence="2">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="WRKY19-like zinc finger" evidence="2">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="WRKY19-like zinc finger" evidence="2">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="WRKY19-like zinc finger" evidence="2">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0721802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="337" mass="36997" checksum="D00FF0E7E754F528" modified="2020-08-12" version="1">MDAYHSHHASRRSMSMWEQPVTKRPLPSLATIDSTKSVHHPMENNTPSQPIPIPSFNLPLPSISHQQHHHSYTPTTEPAPVALPKLRSMSLGEYMPLARRPFEGEPEVAQFNRVPTTTFHIKHEIPVSRSWTPHHNILQHPAANNASSEFSLSRSWNDQAPNLFPRYSSSPSTAASSWTPSPTALQRMSLTNPSSSSDDEDQPDEEADPLNRNSTRVCRTKSCKNVARSKGLCRSHGGGKRCTEPGCSKSAQANKKCIAHGGGTPCSFENCDKTSQSRGLCKAHGGGARCKYPSCPKSSQSRGFCRGHGGGVRCKAEGCEKWVQKNGFCIKHGREQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W7Q2</accession>
    <name>A0A6G0W7Q2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">Ae201684_017808</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the MICU1 family. MICU1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000313">
        <property type="protein sequence ID" value="KAF0723188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W7Q2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004115"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990246">
        <property type="term" value="C:uniplex complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036444">
        <property type="term" value="P:calcium import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051560">
        <property type="term" value="P:mitochondrial calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039800">
        <property type="entry name" value="MICU1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12294:SF1">
        <property type="entry name" value="CALCIUM UPTAKE PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12294">
        <property type="entry name" value="EF HAND DOMAIN FAMILY A1,A2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="234"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="311"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="417"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAF0723188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="481" mass="55736" checksum="F2F54B0BBC69174D" modified="2020-08-12" version="1">MWRSVAALARRQSVFAAAAASSAATALYFSNTSFCDSSKDAVAAKNDNEAPSESEKIVGRYENRLRRFSSPERVFQYFASIRLDKQPYMTRQDFIRALTPYSFRKGDALHSKNPDFNPMITLQAPKKDEVNAYKELIQEIMRLGELEDWKKSPELKKEMEVLMTKLTHDYNMDLQTHLKVLRELNVTYREFQTFIATHGGPEVHNEAFFDLVDADGDGLISYPEFMFFTTLLSIPERQFELVFKMFDDDGNGVIDHREFKEIMDLMRLRTPSGRQDRHLKENSTPTFKNLFGEWEREPLTFEKFCAFRNSLKREVMRLHFDHYDVDGSKELSAREFGMFLVSHVKQTEMDQWVEKVDKLHDLELSITEQEFMDYYTFLENLDAMKVAMELVMEKNGLDKDQFYRAARAACHGGRPLVSKQIVDIIFALFDGSGDGAVSPDEFLGVMESRRSAGLRERRDLGALEFLERVKSCFLECVAEMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W894</accession>
    <name>A0A6G0W894_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_018211</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; riboflavin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DMRL synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000326">
        <property type="protein sequence ID" value="KAF0722733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W894"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000641"/>
    <dbReference type="UniPathway" id="UPA00275"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="entry name" value="Lumazine/riboflavin synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051581">
        <property type="entry name" value="Ca-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34524">
        <property type="entry name" value="CALCYPHOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34524:SF6">
        <property type="entry name" value="CALCYPHOSINE LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="Lumazine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="289"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="325"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="361"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="518"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0722733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="544" mass="57739" checksum="2693C37CDD02EEB9" modified="2020-08-12" version="1">MSTLTSADMGELKRPSTRLHAPPGGGTSWSFGDDSTSTTPPKAKAKGRAGYGHSNVTSDSSPFSTPPPPAPTAATKAPASSTPSTTPAAAPSTASYRSVRGSVRIAVVKTKADDSVVDEFASNFTKALAPSLSYEVVTVPSLEDVPYAANKLALHGGYDGVVVFGLLNTADALFQIQATAVTQALIQISVAAVKPIVRAIFIGESRVASVKAKGGWGAEFAASIEDLVQLGGFIHRANSVKHEAPAASHRGDAKAAANNVFPDSLKSAPREVTETLATLRASLYEHGARGIVGLGRKFRIMDDDNSHTLDLNEFKKAIREHALDLTEDEVAHLFAFFDDDKSGSISYDEFLIGIRGELNERRQQLVLLAFKVIDADGNGVLELDDIIAKYNADKHPDVIAGRRTKNEIFRDFLDTFDGGEKDGKVTPAEFIRYYANVSASIDNDDYFELMIRNAWHISGGEGWSANTTCRRVLVTHADGTQTIEEVKNDIGITGKDAIAAALQAQGVADASSKIETSGYVDSTKPASKAAPKKHGAGDSSIVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0W9Y3</accession>
    <name>A0A6G0W9Y3_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_017699</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000309">
        <property type="protein sequence ID" value="KAF0723357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0W9Y3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004767"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0723357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="264" mass="29803" checksum="D695C857933650A1" modified="2020-08-12" version="1">MASVPQLWGRALDCVNTPLRKRLESALSLLEAPDPWTFLLSSPPIHGRSILSTASEVLKADNVDDIGVWCSLVAGAFVHLPPSHAEEGAVVRLLRKVGPYMTLLPVAIASASLFPPNDESMQTLLCETWETTTPGREFIWEGLVRAFNQVSRIPPSQARALSRCISILLRRDSLLIYQTDFQVLVDILVRESTDLEIQDPRRQSIAVVLQTCLESPVFIRSDLYRQHDLRIVVKQWREALTRDNPRNSTFRELAEVERALEQIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WAE3</accession>
    <name>A0A6G0WAE3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="7">PARP</shortName>
            <ecNumber evidence="7">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_016992</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="7"/>
    <dbReference type="EMBL" id="VJMJ01000273">
        <property type="protein sequence ID" value="KAF0724330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WAE3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_021473"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990404">
        <property type="term" value="F:NAD+-protein mono-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070212">
        <property type="term" value="P:protein poly-ADP-ribosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01437">
        <property type="entry name" value="parp_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.142.10">
        <property type="entry name" value="Poly(ADP-ribose) polymerase, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050800">
        <property type="entry name" value="ARTD/PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004102">
        <property type="entry name" value="Poly(ADP-ribose)pol_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036616">
        <property type="entry name" value="Poly(ADP-ribose)pol_reg_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036930">
        <property type="entry name" value="WGR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008893">
        <property type="entry name" value="WGR_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10459">
        <property type="entry name" value="DNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10459:SF117">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE TANKYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02877">
        <property type="entry name" value="PARP_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00773">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47587">
        <property type="entry name" value="Domain of poly(ADP-ribose) polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142921">
        <property type="entry name" value="WGR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51060">
        <property type="entry name" value="PARP_ALPHA_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51977">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="WGR" evidence="11">
        <location>
            <begin position="56"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="PARP alpha-helical" evidence="10">
        <location>
            <begin position="172"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="PARP catalytic" evidence="9">
        <location>
            <begin position="294"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0724330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="528" mass="59062" checksum="52E5AE8E7696C1C8" modified="2020-08-12" version="1">MTKSVKKRRRSLARALPDDSTHDADSSNTKRTKNSPPKSRFQCVAPVDFAFSAVSPAWVLQDDEDSDVIYDAHLFQVNLESGMNNALVLQVIASDEGCFVWQREYDRRGRREISTSCSEAMTAVDAVDEFMDVFEEKTGVAWEDRSAMSVDPPTGFTYVPMDYPSSSSCGASSTPPKKLQEQVRSLMALVFHDEDEYTSDAAALTPLQLPYAAMAFDKAHFILDQIAAMLGAKSRVRRLKLRQASEAFYSAIPHDFGQPMLDCVIDSMEKIDNCRETLHELRVSCNGRPLLSLDPLHQKYTSLECHLELVATDSLEFNLVTQYLNNSKAHVQYEMKIEHVFRVAKEMEVDKFKPFESFDNRMLLWHGSSLSNWSGILKDGLRIAPPNVTSNGHSFGKGIYFSDSVSRSAPYCRATLDKSKGILLLSEVALGKSNACTATNSRAMNEVDFVEFHSVVGLGSFTPTPGQNHVLPDGATIPLGALKRQSLENKRTHHLHLGSGLEYNEYVIYNPAQTRMRYLVVAEFCFDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WAE7</accession>
    <name>A0A6G0WAE7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_017088</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000278">
        <property type="protein sequence ID" value="KAF0724190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WAE7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_012610"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000001">
        <property type="entry name" value="zinc finger CCCH domain-containing protein 15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000002">
        <property type="entry name" value="Zinc finger protein 36, C3H1 type-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045877">
        <property type="entry name" value="ZFP36-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547">
        <property type="entry name" value="CCCH ZINC FINGER/TIS11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547:SF18">
        <property type="entry name" value="PROTEIN TIS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="82"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="82"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0724190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="213" mass="23684" checksum="475FB1822C1C2ADA" modified="2020-08-12" version="1">MTSVVVLSPSSKQQQQAQQQRMQVLANGDIVDCGRLPTTARNTLYKTELCKHFTETGTCRYGTKCQFAHGHDELRGVLRHPKYKTTKCKAFLTSGKCMYGSRCRFIHDNSSPEDASDDDDEFPMTRAEQDQENMKAAPRHRAAARVNPRRMFDTAIDLSAPGLKLKPVVQATPSLSTPLMRGGALSPSLDNQDADDIGFSRLSIFQKICRASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WCJ6</accession>
    <name>A0A6G0WCJ6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Xylulose kinase</fullName>
            <ecNumber evidence="4">2.7.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_016483</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>D-xylulose + ATP = D-xylulose 5-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17140"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.17" evidence="4"/>
    <dbReference type="EMBL" id="VJMJ01000254">
        <property type="protein sequence ID" value="KAF0724923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WCJ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017084"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004856">
        <property type="term" value="F:D-xylulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005997">
        <property type="term" value="P:xylulose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07776">
        <property type="entry name" value="ASKHA_NBD_FGGY_SpXK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042024">
        <property type="entry name" value="D-XK_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF57">
        <property type="entry name" value="XYLULOSE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="5">
        <location>
            <begin position="135"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="6">
        <location>
            <begin position="300"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0724923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="552" mass="60378" checksum="CE8A02BC01184D41" modified="2020-08-12" version="1">MALFLGLDCSTQSMTGVVIQSDDANSTFAVLASASCQFDQTLPHYGTSNGVLIHDGHVEVPSLMLVEALDIMLEDLRVALEKTSHSFSEIKAVSGSGQQHTTVFWHHDSLEMPTVGLLSAFFKEKNVFFPPNGRSWMDSSTTKYCRQLEEALGGAQRVADLTGSRAYERFTGIQLLSLGEIDQVSRVSIVSSMLTSLFRGEYSPIDRSDASGMNLMDIRSRKWSPEVLDAIEKINGPRKSTLTRYLINDPVPSHKSLGGIAPYFTKNYSFSPDCAVIPFSGDNPCTLAGMGLSQPGDIGISLGTSGCVFAVGSSDDIQPSGSEGHVFVNPIDTSTYMAMLCYKNGSLARENVRNRRADSNWETFSRLMEQSPPGNNGYLGFFFLQPEITPVVPAESESQTLSGIYGYDSQGKPVDFSELPPEVEVRAIVEWQCLSMYYYTQKLYRGVMKRLIVGGGASANQTLLDTIANVYNAPVYVEVSRVNTAALGGALRAQHGYNCSLQEADQPFNPAVTWELKAVPNENIHAVYKEILGRFAELEAKSIQSQVERFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WDJ6</accession>
    <name>A0A6G0WDJ6_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mechanosensitive ion channel MscS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_016166</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000243">
        <property type="protein sequence ID" value="KAF0725395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WDJ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009945"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045275">
        <property type="entry name" value="MscS_archaea/bacteria_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_beta-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30221">
        <property type="entry name" value="SMALL-CONDUCTANCE MECHANOSENSITIVE CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30221:SF1">
        <property type="entry name" value="SMALL-CONDUCTANCE MECHANOSENSITIVE CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Mechanosensitive ion channel MscS" evidence="7">
        <location>
            <begin position="176"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="293"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="297"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="311"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0725395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="418" mass="46318" checksum="75A93E58A22E2A40" modified="2020-08-12" version="1">MANFTATILRVGIGLALIVVVAYFRDICVRSFFRFVRERFGRSVFLGDVERHFTTSISIAIVLLACFVGFVIAGYNDVPTVNTIFLYAAGILLILSTRAFRIVFTKWLIRSLGWDVTVREDYSRVLIVTEGIGVIVFFIISIEIFAIFVPSTTAVGDIVVVFFIILEAVCILSFYTTVQNAVAGFFLIFAEPFRLGSLCAIGTSTGVVERIALHSTRLRAEDGAVIHVPNGILANDVQRNFTDCSFRRVHLLVHVAHNTPLSRVLLLIHHLKEELVSCVISLDQFLDQIEKLKPPSEDTEDSDTDDERTSVVGSLRTSRKQPSVTRDRDLAVSAASTDVSESMMGLDDLSRSTLTRNVPATVDPRLLQVTLGGMYRIWVSALVPGNDLMGIAMAKSNLNLAIMRCLESHRIPLHASRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WEL8</accession>
    <name>A0A6G0WEL8_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_016364</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000250">
        <property type="protein sequence ID" value="KAF0725133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WEL8"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_015285"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032053">
        <property type="entry name" value="Ribosomal_mS34"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28589">
        <property type="entry name" value="28S RIBOSOMAL PROTEIN S34, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28589:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16053">
        <property type="entry name" value="MRP-S34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0725133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="95" mass="10604" checksum="092ECD3C7C127AE8" modified="2020-08-12" version="1">MTTTAVTAAVKRNLFQTICGKRNFGVGQKVTRAIWDRYETAAENPGPSFIEITRVVPSPDLKHGKAYGIKTFRGVSEGKERRVDGPLKKDWRIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WF36</accession>
    <name>A0A6G0WF36_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WRKY transcription factor 19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_015659</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000229">
        <property type="protein sequence ID" value="KAF0725994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WF36"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_013876"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31827:SF1">
        <property type="entry name" value="EMB|CAB89363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0725994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="20029" checksum="7915EFA7A0D5C8CD" modified="2020-08-12" version="1">MTATSTDTRRRLRPNCIVQGCSNQAYARQLCCRHGAKKTCSVEGCDLRARSNGICFAHGAPKRQCNEPGCDHPAQARKKCVKHGGGRRCNAPGCIAHARCKGKCQRHAAIDTPLDMMAFWGVPDKVHHKRSYSVDSSDDVATLDLPPVQIFDDSNMQYTQDHSQTCGDVMMMEVYSLLLNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WG57</accession>
    <name>A0A6G0WG57_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Ae201684_015671</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="VJMJ01000229">
        <property type="protein sequence ID" value="KAF0726006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WG57"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009520"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF519">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE MPK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="8"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="7">
        <location>
            <begin position="66"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="151"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="226"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAF0726006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="262" mass="29095" checksum="F27CAE1ECABF33E3" modified="2020-08-12" version="1">MDVAEFDTPGAILPTLYVGSAAHALNIILLHRHAITHLLCLDVAIPPRLVLPCTHVPMSPAPQDDSELALALKNCLPHIQAAIESRQVLLIFCSRGFNRAVAVSIAYLVSELHWTLRKAYRFLQERRRGFVLNTQYFIQLQDMEANLHEGECSLPDPTVEEQPVWRGLQTPDGDTTDDDESLQAPLTDTSSRGSEMHTLDRASVATNVSISTMRGKTKELENFYTKEEDDDDVEVSAPTVPQVPLVPPPKKRHRGGIPCCTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WGF7</accession>
    <name>A0A6G0WGF7_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CBM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Ae201684_015523</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000223">
        <property type="protein sequence ID" value="KAF0726191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WGF7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_007985"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014188"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017221"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35923:SF2">
        <property type="entry name" value="ENDOGLUCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35923">
        <property type="entry name" value="MAJOR EXTRACELLULAR ENDOGLUCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="6 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026102481" description="CBM1 domain-containing protein" evidence="10">
        <location>
            <begin position="21"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="11">
        <location>
            <begin position="22"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="65"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="78"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAF0726191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="615" mass="65938" checksum="2E02A345861E8454" modified="2020-08-12" version="1">MKIAVAIAFVASSILGLTSAQAPVGAYGQCGGNGYTGSKTCVSGYVCNTYSEWYAQCVPGSNNNPVPTNPTTSPPSIAPTTTPKTTQPTAAPTKQPTPSTTTPTVKPTTAPTAAPTVAPTTKQPTPAPTQSTVKPTASPVPPSSAPPSNGQLNFRATTDGILLNGSPFFFKGANYFGMEGDISVPHGLWGGGQSTTIQKIATLLKNNGFNAVRLPFAVDAVLSNKAIDPTKIVNEVALVNQFSGKTLSSAPPSNGQLNFRATTDGILLNGSPFFFKGANYFGMEGDISVPHGLWGGGQSTTIQKIATLLKNNGFNAVRLPFAVDAVLSNKAIDPTKIVNEVALVNQFSGKTLSYFDVMDYTIKIFADNKIVVLLDAHVLTASSGITELWYTSSADQNNFENAWKIVATRYKDTWNVIGADLKNEPHGAATWGSGNSATDWNQAATKWGTTILQIAPRWLIFVEGIAQSSRDQAAYPTFWGENLMDVQRAPITLPVADRLVYSAHVYSSDVSNQPYFSASNYPDNMPSIWDLHFGFVNKKYGPLIMGEWGGKYLASSDIQWQNKFASFLQTNNIGFFYWSLNPNSGDTQGLLADDWNTPRTDKLNMLSIFKGTTIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WGN3</accession>
    <name>A0A6G0WGN3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_015419</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000219">
        <property type="protein sequence ID" value="KAF0726304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WGN3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_014430"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_020403"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF467">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="218"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0726304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="585" mass="66599" checksum="FA0D9F13B01113E9" modified="2020-08-12" version="1">MYVGNEPDVKGYCLYCQKFFVSRNVQFNEANSYHADSPSPLLLPAQDIFADEDSRRDESPPPPRRSTRIRRPPTRFMDTTPVFQPAASSPPQSTSVPTSEQHEDVIDDSVSNTQEDVNPMVEDLSTSIPVALDDSEDMDVSTIYDAPFLRRRPREETIDEDFETEDDIIVSKRQRILVAFAVHSTGLPTTIQQAHSSSEREEWIKATNAEYDSLMEHETWTLCELPPGRKPIGCRWLFTKKYSADGSLLRYKARLVAQGFTQVAGIDYTDIFAPVIRTSSIRFLLSLAALQSMHICHMDVQTAFLNGNLQETLYMRQPPGYVQPGQDHLVCRLNKSIYGLKQYSREWNSALDSYFKSKGFVQLKTGPCIYFQRTRQGLVLVGVYVDDFILLSTSRSVLETTKRNLSSRFHMKDLGNLAFCLGIEVERLQDGSIFFHQRKYILDLLATHGFTDCNPISTPQASSATRSSTASSPLPFRQVVGELLYLTTTTRPDIAYTVTLLSRHLNEPAEEHQQIAKRVLRYLKGTQDYGLLYSKSDKEDFTIDLYVDADYANDISTRRLPALSQRMMLDFVEIKATEYRCSFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WH48</accession>
    <name>A0A6G0WH48_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_015288</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000215">
        <property type="protein sequence ID" value="KAF0726474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WH48"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_004865"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0726474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="381" mass="42859" checksum="AE092C92B4EE55FD" modified="2020-08-12" version="1">MLPFLPLQALEQAYELTLAHTDEIGVVFGPWYNAYGLERIPRLLAALPFMKLMALAHCVRVGDKQLLQVIASISTEDIPRVRDFVGELVAIAIDSDQVDILAALECIGYTREIYKGELVFGIGDAVSQGHMTMADYLASEVKKIDTKSLKDFFNGADRARMKTNLTTIFATKTFEGLQWLLQVWTKLLPSTWMTRCRRDCRTLALQFEAWDILTMLTKDERNKTAKYDEDLIHAMRLALLEGVTWLLSSAGVVAKSWHIVEASKTFQCGNPNSSAILERLLANWLPTVLGTSTKVVCLDTSMDEALRRGYLEAIQVIWKMTASTSTLQQYGTPSTIREFAALGVFTKYVAPNPHWSCDGWVPIVPKDATEIEYRYTIIDMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WHK1</accession>
    <name>A0A6G0WHK1_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Ae201684_015078</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peroxisomal targeting signal receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000210">
        <property type="protein sequence ID" value="KAF0726678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WHK1"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_011999"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005052">
        <property type="term" value="F:peroxisome matrix targeting signal-1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000698">
        <property type="entry name" value="Peroxisomal targeting signal receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024111">
        <property type="entry name" value="PEX5/PEX5L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130:SF0">
        <property type="entry name" value="GH08708P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 1 RECEPTOR PEX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="316"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="350"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="452"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="486"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="520"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAF0726678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="593" mass="66992" checksum="7C9D5C6F466C7780" modified="2020-08-12" version="1">MDLLGKLAQGGCAADGTVAARNPLSQALDGVLRVGPMGRPATQAPGPMPQGQYMEHDLHQAMQEAQHMQDQPFHPLQMHPDPRMMNMPPPPQVDMNHAWQQQYISRDNMQRQMDHAFQSAVAAPAPMHDVQQRMPLQENRSFVPMQQYPPPYMQSMYHPPGMHMMQPPPMLTQQPMVYEQQQVESSVVQQVEPASSSDTQRISREVADTMRQSSDERFQNSEFLKFMDKVVSGKAELNDAENTVIHHTSEEDHLADLLEKDLNLGAGLDTKALEEIWEKAMQEGQLVDPFQDTWNQESTTVDLSYDFASENPYMADTNSFELGCSLFREGNLKQAILAFEAALQETPDHSEAWRMLGECHAENDQDKLAIVCLNRAVEEDPYNLDALLALGVSNVNELKSHGALKTLQAWVQHNPKFHGLQVQLDDAYGDGSLMDEVMQLMLQAQAYDPQDSDVQVVLGVLYNVSKDYDAAVRCFRSAASARPDEYSLWNKLGATLANSSRSNEAIPTYHRALEIKPKYARGWLNLGISHANLGQYEDAAHCYLQALQQNDQADHIWSYLRIAFTCMERFDLVKLTDMKDIAAFRNEFRLVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WHU7</accession>
    <name>A0A6G0WHU7_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Ae201684_015043</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000207">
        <property type="protein sequence ID" value="KAF0726787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WHU7"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003309"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026071066" evidence="3">
        <location>
            <begin position="22"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAF0726787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="384" mass="40412" checksum="1D567F45F79C7E35" modified="2020-08-12" version="1">MGSVRIGTMLLAGVGHTIALAALDDAINGTNDTAAPKNTPVPTPKPTTTSPPPSPTMTTETTTTVLPPTQEPTATPSPPPTTTLEPTPPPTTTIITTTVAPTTTLPPTPTPTPETTPTPTNTTIPTATIVFTPSSTPPTEPPPDTPAPETSTEVASSSLPPTSTVVASTNAGNKAESLSAGATACIIIGSLIVVCVAVIVVLRRRQAQKKRLSDKQRSGAGRTTQYSVEGGGVAMIDMTSPHHVYKHKSPVPVLSLRHYDASGLTSPKEDSIHSDHAPTISSSYTMFHRQPSDSIDSYQPSPHRNMYRDMMSPATTMSPTRPSSMMLSDQMSPGSRHLRSDLSSFSINFSRVSSMSAMGPHTSHLLRNSDDLSVYSDRTSETTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WIL3</accession>
    <name>A0A6G0WIL3_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_014783</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000202">
        <property type="protein sequence ID" value="KAF0727043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WIL3"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_003721"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.790:FF:000001">
        <property type="entry name" value="50S ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01318_B">
        <property type="entry name" value="Ribosomal_uL1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005878">
        <property type="entry name" value="Ribosom_uL1_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_uL1_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01169">
        <property type="entry name" value="rplA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36427">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36427:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL1M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0727043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="263" mass="28103" checksum="8D80FF06BD00DA37" modified="2020-08-12" version="1">MALLVRCRATLASRGMQVRSIALATRFPETAFEIKSNDVKKPLLSLPDALTLCKQHAVRKFDETVDIVVELGVDPRKPNQSVRGVVMLPNGTGKVVRVAVFAKGDKADEARAAGATIVGAEDLLADIQAGKIDFDRCVATPDMMGLVGRVARVLGPRGLMPNPKLGTVTQDVTAAIQAAKGGQVEFRAEKKGIVHAGVGKVSFSDEALVENIRAFMVAIGEAKPEGAKGKYIKACHLSSTMGPGIRLESRFLDPSSPHFMRFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WIP2</accession>
    <name>A0A6G0WIP2_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_014825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000202">
        <property type="protein sequence ID" value="KAF0727088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WIP2"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0727088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="183" mass="20701" checksum="F2024E2521E418E8" modified="2020-08-12" version="1">MIATSSGWQWLVELAGRGLVGHVTVEIVNKHQRRSFDIWRKHTFQTCPSGNVGISSVSMMPPGHPLMTNRIGSFPPSARIVKTAVIRYECFSPPEIFDEPPRTAYVRGSTLPLLIILASQIIFDGISIKSDCRQVFLCHFGHGCTLSAEAMTVRESFQQTYHSFAWYFKHLWSSVQPENSRME</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WIY4</accession>
    <name>A0A6G0WIY4_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_014690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000200">
        <property type="protein sequence ID" value="KAF0727159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WIY4"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_016448"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0727159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="201" mass="22834" checksum="A0C78F3D47D1B49C" modified="2020-08-12" version="1">MIRHQASVINHFIDQAKRQDDRLDAMEAKLDAQKSTTEQIAECQARPVVATIPASDPQSPPKCRRKASNVPLRAVWYEWYTSEPRLWVKCTHKQKRSDSKLHVAYLKLFLDSGLKLDDKASAYRDNIMSLALLVEEWVLAFLSQHGSMSKGANAVLKMMRSLHRTGKLNGRIVTHRRLIAARAILDPSPAYTQDVLDTRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WJ30</accession>
    <name>A0A6G0WJ30_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phenazine biosynthesis protein PhzF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Ae201684_014738</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000200">
        <property type="protein sequence ID" value="KAF0727209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WJ30"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_000123"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003719">
        <property type="entry name" value="Phenazine_PhzF-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00654">
        <property type="entry name" value="PhzF_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774:SF39">
        <property type="entry name" value="BIOSYNTHESIS PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774">
        <property type="entry name" value="PHENAZINE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02567">
        <property type="entry name" value="PhzC-PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016184">
        <property type="entry name" value="PhzC_PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR016184-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAF0727209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="31642" checksum="AB12C1F8F7D9CD72" modified="2020-08-12" version="1">MAARFTVHHYDSLLATRGAPGGNKAGIVHLDGGFPSDQVMQTVAKIVGFSETAFFTKDDKKVHIQFFTPEGEVDLCGHATVAAFSALERDSTFEMHTKKSILTVATDSTGRVTMDQDLPSFEEPKPNVIPSVLEALGLTIDDVCFDEIPLTIVSTGLPDLFVAVKSREVLNQILRPDVEKIAAISKRLTTIGFHVFTLDVDEGFTAECRNFAPLYGIDEEAATGTSSGALGSLLCHVAKDFTTFTRHMVFLQGSAMQLPSRIESTVSIENGSIVRVSIAGIAEPCGSQEVEVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WKD0</accession>
    <name>A0A6G0WKD0_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Ae201684_014325</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methylthiotransferase family. MiaB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000191">
        <property type="protein sequence ID" value="KAF0727701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WKD0"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009173"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035597">
        <property type="term" value="F:tRNA-2-methylthio-N(6)-dimethylallyladenosine(37) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080090">
        <property type="term" value="P:regulation of primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12160:FF:000003">
        <property type="entry name" value="CDK5 regulatory subunit-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.30.20:FF:000003">
        <property type="entry name" value="CDK5 regulatory subunit-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="entry name" value="Methylthiotransferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="entry name" value="tm_1862 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006463">
        <property type="entry name" value="MiaB_methiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00089">
        <property type="entry name" value="MiaB/RimO family radical SAM methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43020">
        <property type="entry name" value="CDK5 REGULATORY SUBUNIT-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43020:SF2">
        <property type="entry name" value="MITOCHONDRIAL TRNA METHYLTHIOTRANSFERASE CDK5RAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00273">
        <property type="entry name" value="(dimethylallyl)adenosine_tRNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01082">
        <property type="entry name" value="B12-binding_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00413">
        <property type="entry name" value="CDK5RAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01061">
        <property type="entry name" value="methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="8">
        <location>
            <begin position="72"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="9">
        <location>
            <begin position="221"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAF0727701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="599" mass="67156" checksum="5BC08A4427CC9402" modified="2020-08-12" version="1">MIRSSRSIALVQRYAAAFSTERMVTRTTISNGPGLSDFIRDSQEQKVVAPTEESTMNMPSRVTELDEIQRTKSFHIETYGCQMNSSDSEIVRAILLKHGYTDKPTSDEADIVLLNTCAIRENAEAKIWRRLDVFKQNKIKARKQKKGTPTQTVGVLGCMAERLKTKLLESDKMVDLVVGPDAYRDLPNLLDVLTQGAQDTAVNVQLSLDETYADIAPVRSDDSNPAAFVSIMRGCNNMCSYCIVPFTRGRERSRDVSSIVDNVKSLRDQGVREIVLLGQNVNSYHDKQTEGAQEHGRAYVPASGFENMFKARDALGYRFVDLLDRVSAVDPEIRIRFTSPHPKDFPDDVLHLVNERANICKSIHMPVQHGHSDVLARMRRGYTREAYLSLVDNMRSIIPGVALSSDFIAGFCDETEEEHRATLSLMRQVCFDHAFMFAYSMRAKTHAAHRMEDNVEESVKLRRLAEVIDTYNTVVTAKNRVEDQDRLHIVLVQGTSRRSLANLTGLTDTNKRCVFPDMAVAPDASMLWNPTLGDFEAVAANAPSVSLQKGDYALVRVHEAGRHTLHATPLARTTLGEMRQLVPRELLGARSHDLSKLML</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WKD2</accession>
    <name>A0A6G0WKD2_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Plus3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Ae201684_014312</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000191">
        <property type="protein sequence ID" value="KAF0727687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WKD2"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_009162"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990269">
        <property type="term" value="F:RNA polymerase II C-terminal domain phosphoserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.200">
        <property type="entry name" value="Plus-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004343">
        <property type="entry name" value="Plus-3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036128">
        <property type="entry name" value="Plus3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13115">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN RTF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13115:SF8">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN RTF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03126">
        <property type="entry name" value="Plus-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00719">
        <property type="entry name" value="Plus3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159042">
        <property type="entry name" value="Plus3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51360">
        <property type="entry name" value="PLUS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Plus3" evidence="6">
        <location>
            <begin position="279"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="159"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="27"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="113"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAF0727687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="683" mass="77109" checksum="B1FF6C8E77444470" modified="2020-08-12" version="1">MAKRIEESDSESGSASESGSGSGSDSGSGSESGSDSGSGSDSGSGSDSDSGSESESGSGSESESEDEKPKKEKPKAKPKVKAEKAPKKKSPSKPAKPAVKKPAKKIIDDDDTTEPKIEEIDPEKLKGLNEVEKEALILEHYESQTKKSKELALKKKLESEKEALEDNDVPSRRLRNKDADSRKSALSNLKSIKQGDKSAKSSILSKRFGNDDDDDDYEGGETNRELAEKRRRRKELQRTVAESSSSKPSATSSSSRVDAVQSSKDPDHVELEEPDVSGPLELRHAQAYLLKRRVWFEKYYFEPFFGKLVKGNYCKVAIEDKEDGERVYRFCEVLHTCILDKEYIFLGETTKTGVMLAYGKEKRAWALSVLSNHSLTEKEFLHWRFFRQKVGLSLPTKDQVKKFYSMNGEIPKRHKYTDEEVTQMVNRKKAVGLSHVALGVERVRLERDVEAAKGVGNYSKAMELEERLEKVRRANEQRLAIKPDDVQRINEINARNREINMKRDMDASETNKAQMESMSAAQKLQYVRASASRRMFMSRDKIEANLADGKLIKLEDGRIMTVNKTQEIEALPDDIIPENTASAKDEDVLVKIERKRKLQQAMEIEPRVADVQIEGEGDIANKTIRLKEEDGTWTTIRPANEILQELELKKRPVVSEEQKKARKGLTMQEYFNRVKQRRAEEMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WLV5</accession>
    <name>A0A6G0WLV5_9STRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Ae201684_013834</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000179">
        <property type="protein sequence ID" value="KAF0728283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WLV5"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_017247"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAF0728283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000481153"/>
        </source>
    </evidence>
    <sequence length="189" mass="21223" checksum="D9ED75A1861F9F74" modified="2020-08-12" version="1">MCVQALVQKLFATVKADAPRDYLVLGEIAALQDTGKIPLPVDLMHLGILFELNGSDRDMMTPGQFELDAICDFVERCLEQEKREAHPLAPSLFKYNKEAQSLFGLWQVAADDGIEVIVAWLMAVLQQNSTLEAPGLDDATLDLLQRVLCLDDGWKQDMMSTPSDIETFLLNFFTGWMNQLGRFGIKRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6G0WLX9</accession>
    <name>A0A6G0WLX9_9STRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Ae201684_013848</name>
        <name evidence="6" type="ORF">Ae201684_013849</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aphanomyces euteiches</name>
        <dbReference type="NCBI Taxonomy" id="100861"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Stramenopiles</taxon>
            <taxon>Oomycota</taxon>
            <taxon>Saprolegniomycetes</taxon>
            <taxon>Saprolegniales</taxon>
            <taxon>Verrucalvaceae</taxon>
            <taxon>Aphanomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <title>Genomics analysis of Aphanomyces spp. identifies a new class of oomycete effector associated with host adaptation.</title>
            <authorList>
                <person name="Gaulin E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 201684</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VJMJ01000179">
        <property type="protein sequence ID" value="KAF0728297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VJMJ01000179">
        <property type="protein sequence ID" value="KAF0728298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6G0WLX9"/>
    <dbReference type="VEuPathDB" id="FungiDB:AeMF1_006934"/>
    <dbReference type="Proteomes" id="UP000481153">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/
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